Improving accuracy of ET measurement of LISS nozzle to calandria tube clearance

International Nuclear Information System (INIS)

Craig, S.T.; Krause, T.W.; Schankula, J.J.

2006-01-01

The AECL Fuel Channel Inspection System (AFCIS) has been used in an in-reactor field trial to successfully measure the clearance between Liquid Injection Shutdown System (LISS) nozzles and calandria tubes. Each measurement over the full length of a channel added only 15 minutes to the on-channel inspection time. No changes were required to the inspection heads. The only equipment changes made were the addition of a Remote Field Eddy Current (RFEC) module to the eddy current instrument, and minor wiring changes, at the instrument, to achieve a RFEC configuration. With the experience gained from the field trial, factors potentially limiting accuracy were identified. These, and other factors, were investigated and are discussed herein. The RFEC probe is delivered inside the pressure tube. Magnetic fields from the RFEC probe extend through the conducting walls of the pressure tube and calandria tube to interact with the LISS nozzle. Data acquired during the field trial showed the LISS nozzle signal is distinct and the signal-to-noise ratio is very favourable. Nevertheless, comparison of the RFEC measurements to a visual examination, made during the same outage, had the RFEC method underestimating the clearance by 2.5 mm on average. By way of laboratory tests, the following factors were investigated as potential sources of error: resistivity and geometry of LISS nozzle reference/calibration pieces, pressure-tube wall thickness, diameter and resistivity variations, pressure-tube to calandria-tube gap, and radial offsets of the probe within the pressure-tube. The sensitivity to these various noise sources was established. A model, based on fundamental electromagnetic principles, was developed and was used to normalize the effects of LISS nozzle conductivity and geometry. This enabled compensation for various sources of error, and made it possible to produce a correction factor for the field trial data, reducing the average difference from the visual inspection of LISS

Augmentation de l'expression de la chaine α1 de la laminine 111, un potentiel traitement pour la Dystrophie musculaire de Duchenne

OpenAIRE

Perrin, Arnaud

2016-01-01

La protéine hétérotrimérique laminine-111 permet le lien entre la matrice-extracellulaire et l’intégrine α7β1 du sarcolemme, remplaçant ainsi dans les muscles dystrophiques, des liens normalement assurés par le complexe de la dystrophine. L’injection de laminine-111 dans des souris mdx a permis, entre autre, l’augmentation de l'expression de l'intégrine α7β1, d’empêcher les bris du sarcolemme lors de la contraction musculaire, de restaurer un niveau normal de la créatine kinase sérique, ainsi...

Envenimation scorpionique compliqué d'un accident vasculaire cérébral ischemique

Science.gov (United States)

Bibiche, Youssef; Berdai, Adnan; Labib, Smael; Harandou, Mustapha

2015-01-01

Les piqûres de scorpion sont dans un certain nombre de pays, un accident fréquemment rencontré, et un risque grave. Au Maroc, les données épidémiologiques établies par le centre anti-poison (CAPM) montrent que les piqûres scorpioniques se placent en tête de toutes les intoxications relevées par le centre (60%). Les envenimations scorpioniques posent un grand problème de santé publique. L'apparition de signes neurologiques lors d'une envenimation scorpionique témoigne d'une envenimation grave et correspond au stade III de l’échelle de sévérité. Nous rapportons le cas d'une envenimation scorpionique compliqué d'un Accident vasculaire cérébral ischémique (AVCI) chez un enfant. PMID:26175806

Banana orchard inventory using IRS LISS sensors

Science.gov (United States)

Nishant, Nilay; Upadhayay, Gargi; Vyas, S. P.; Manjunath, K. R.

2016-04-01

Banana is one of the major crops of India with increasing export potential. It is important to estimate the production and acreage of the crop. Thus, the present study was carried out to evolve a suitable methodology for estimating banana acreage. Area estimation methodology was devised around the fact that unlike other crops, the time of plantation of banana is different for different farmers as per their local practices or conditions. Thus in order to capture the peak signatures, biowindow of 6 months was considered, its NDVI pattern studied and the optimum two months were considered when banana could be distinguished from other competing crops. The final area of banana for the particular growing cycle was computed by integrating the areas of these two months using LISS III data with spatial resolution of 23m. Estimated banana acreage in the three districts were 11857Ha, 15202ha and 11373Ha for Bharuch, Anand and Vadodara respectively with corresponding accuracy of 91.8%, 90% and 88.16%. Study further compared the use of LISS IV data of 5.8m spatial resolution for estimation of banana using object based as well as per-pixel classification and the results were compared with statistical reports for both the approaches. In the current paper we depict the various methodologies to accurately estimate the banana acreage.

Repeat LISS treatment for femoral shaft fractures due to hardware failure: a retrospective analysis of eleven cases.

Science.gov (United States)

Li, Xu; Xu, Xian; Liu, Lin; Shao, Qin; Wu, Wei

2013-10-01

To evaluate the effectiveness of a replating technique having a less-invasive stabilization system (LISS) for femoral shaft fractures due to LISS failure in adults. There were 11 patients with hardware failure of LISS for femoral shaft fractures, on an average of 50 days after the primary operation. The failed implants were removed, and the fractures were replated with a LISS following the rationale of biological osteosynthesis. Radiological fracture union and incidence of postoperative complications were employed to evaluate the effectiveness of this replating technique for femoral shaft fractures. Operative duration including removing failed hardware and replating fractures averaged 81.5 min, with an average blood loss of 330 ml. Patients had an average follow-up of 25.7 months. Radiological evaluation indicated that fracture union occurred in an average of 4.4 months in all patients. The length and alignment of the affected limb were satisfactory, and hardware failure did not recur. The replating technique with LISS for femoral shaft fractures due to hardware failure of LISS can obtain satisfactory results when the appropriate rationale of biological osteosynthesis and functional exercise is followed.

Evaluation of IRS-1C LISS-3 satellite data for Norway spruce defoliation assessment

Energy Technology Data Exchange (ETDEWEB)

Falkenstroem, H.

1999-02-01

Satellite based remote sensing supported by air photo and field surveys, provide a means to area covering forest health assessment on a regional scale. Landsat TM data has been extensively used in studies of spruce and fir defoliation in Europe and North America. The temporal coverage of Landsat TM in combination with cloudiness however restrict the availability of data. In this study the LISS-3 sensor onboard the Indian Resource Satellite, IRS-1C, was evaluated for defoliation assessments in Norway spruce (Picea abies) in the central part of Sweden. The near infrared wavelength band proved to be best correlated with mean stand defoliation. After normalisation of satellite data for topographic conditions, the correlation coefficient increased from -0,19 to -0,83. Normalising satellite data for species composition did not improve the results though. The correction coefficients involved in the procedure were originally developed for Landsat TM, and proved to be inadequate for the LISS-3 data set. A thorough examination of the effects of species composition on LISS-3 data is needed to yield better results. The correlation between observed defoliation in the verification stands and predicted (based on the inverse regression function between corrected NIR values and defoliation in reference stands) was 0,70, despite a very limited range of defoliation in the verification set. IRS-1C LISS-3 is fully comparable to Landsat TM for spruce defoliation studies, although the results would probably not be significantly improved 49 refs, 7 figs, 10 tabs

Generation of a new spectral format, the lifetime synchronous spectrum (LiSS), using phase-resolved fluorescence spectroscopy

International Nuclear Information System (INIS)

Shaver, J.M.; McGown, L.B.

1994-01-01

A new fluorescence spectral format is introduced in which fluorescence lifetime is shown as a function of synchronously scanned wavelength to generate a Lifetime Synchronous Spectrum (LiSS). Lifetimes are determined in the frequency domain with the use of Phase-Resolved Fluorescence Spectroscopy (PRFS) to obtain the phase of the fluorescence signal. Theory and construction of the LiSS are presented and experimental results are shown for solutions of single components and simple binary and ternary mixtures. These results show how the lifetime information in the LiSS augments the steady-state intensity information of a standard synchronous spectrum, providing unique information for identification of components and resolution of overlapping spectral peaks. The LiSS technique takes advantage of noise reduction inherent in the extraction of lifetime from PRFS in addition to standard spectral smoothing techniques. The precision of phase determination through PRFS is found to be comparable to that of direct phase measurements at normal fluorescence intensities and superior for low-intensity signals

Accident vasculaire cérébral ischémique révélant une maladie coeliaque

Directory of Open Access Journals (Sweden)

Belfkih Rachid

2010-04-01

Full Text Available La maladie cœliaque (MC de l’adulte est une pathologie fréquente dont la présentation clinique est polymorphe. Les manifestations extradigestives sont multiples et rendent le diagnostic difficile lorsqu’elles sont isolées. Nous rapportons le cas d’un patient de 52 ans qui présentait un accident vasculaire cérébral ischémique (AVCI. Le bilan étiologique objectivait une hyperhomocystéinémie avec une carence en vitamine B12. La biopsie duodénale était en faveur d’une maladie coeliaque. Les anticorps antigliadines étaient positifs. Le patient fût mis sous régime sans gluten, anti-aggrégant plaquettaire et hydroxocobalamine avec une évolution favorable.

Development and design of a line imaging spectrometer sampler (LISS) - A user manual

DEFF Research Database (Denmark)

Jørgensen, R.N.; Rasmussen, P.

2002-01-01

The objective of this report is to develop and describe the software for a Line Imaging Spectrometer Sampler (LISS) to perform measurements of spectra combined with a digital RGB photo of a measurant. Secondly this report should enable users to performmeasurements with the system. The measuring...... are developed as a Graphical User Interfaced (GUI) hosted by Matlab Release 12 from Mathworks. This GUI enables the operator to perform measurements from alldevices simultaneously together with notes specific for the measurant and store all the data in one Matlab data structure. The software includes dynamic...... exposure of the two CCD cameras ensuring optimal use of 16 bit range under unstable illuminationconditions. A routine, handling dark frame subtraction in a robust manner minimising the effect of hot pixels is also included. This report enables a novice user to perform measurements with LISS relatively easy...

Reverse Less Invasive Stabilization System (LISS) Plating for Proximal Femur Fractures in Poliomyelitis Survivors: A Report of Two Cases.

Science.gov (United States)

Yao, Chen; Jin, Dongxu; Zhang, Changqing

2017-11-15

BACKGROUND Poliomyelitis is a neuromuscular disease which causes muscle atrophy, skeletal deformities, and disabilities. Treatment of hip fractures on polio-affect limbs is unique and difficult, since routine fixation methods like nailing may not be suitable due to abnormal skeletal structures. CASE REPORT We report one femoral neck fracture and one subtrochanteric fracture in polio survivors successfully treated with reverse less invasive stabilization system (LISS) plating technique. Both fractures were on polio-affected limbs with significant skeletal deformities and low bone density. A contralateral femoral LISS plate was applied upside down to the proximal femur as an internal fixator after indirect or direct reduction. Both patients had uneventful bone union and good functional recovery. CONCLUSIONS Reverse LISS plating is a safe and effective technique to treat hip fractures with skeletal deformities caused by poliomyelitis.

Modelling of liquid injection shutdown system (LISS) in ACR-1000

International Nuclear Information System (INIS)

Boubcher, M.; Colton, A.; Donnelly, J.V.

2008-01-01

Modelling of the Liquid Injection Shutdown System (LISS) in the ACR-1000 reactor core must account for the major phenomena that occur following its activation, namely the moderator hydraulics and core neutronics. The former requires modelling of the poison volumes, their time of entry into the reactor, and their propagation into the moderator after emission from the nozzle. The latter requires the reactivity worth of varying volumes and geometries of poisoned moderator fluid in order to simulate the reactivity effect of the injected poison. The time-dependent poison map is generated from hydraulic calculations, and then the neutronics data for standard geometries and concentrations is constructed using DRAGON. (author)

Automated Registration of Images from Multiple Bands of Resourcesat-2 Liss-4 camera

Science.gov (United States)

Radhadevi, P. V.; Solanki, S. S.; Jyothi, M. V.; Varadan, G.

2014-11-01

Continuous and automated co-registration and geo-tagging of images from multiple bands of Liss-4 camera is one of the interesting challenges of Resourcesat-2 data processing. Three arrays of the Liss-4 camera are physically separated in the focal plane in alongtrack direction. Thus, same line on the ground will be imaged by extreme bands with a time interval of as much as 2.1 seconds. During this time, the satellite would have covered a distance of about 14 km on the ground and the earth would have rotated through an angle of 30". A yaw steering is done to compensate the earth rotation effects, thus ensuring a first level registration between the bands. But this will not do a perfect co-registration because of the attitude fluctuations, satellite movement, terrain topography, PSM steering and small variations in the angular placement of the CCD lines (from the pre-launch values) in the focal plane. This paper describes an algorithm based on the viewing geometry of the satellite to do an automatic band to band registration of Liss-4 MX image of Resourcesat-2 in Level 1A. The algorithm is using the principles of photogrammetric collinearity equations. The model employs an orbit trajectory and attitude fitting with polynomials. Then, a direct geo-referencing with a global DEM with which every pixel in the middle band is mapped to a particular position on the surface of the earth with the given attitude. Attitude is estimated by interpolating measurement data obtained from star sensors and gyros, which are sampled at low frequency. When the sampling rate of attitude information is low compared to the frequency of jitter or micro-vibration, images processed by geometric correction suffer from distortion. Therefore, a set of conjugate points are identified between the bands to perform a relative attitude error estimation and correction which will ensure the internal accuracy and co-registration of bands. Accurate calculation of the exterior orientation parameters with

Comparison of satellite imagery from LISS-III/Resourcesat-1 and TM/Landsat 5 to estimate stand-level timber volume

Directory of Open Access Journals (Sweden)

Elias Fernando Berra

2017-01-01

Full Text Available After Landsat 5 activities were discontinued, sensors on board ResourceSat-1 satellite have been pointed as an option for Landsat series. The aim of this study is to estimate timber volume from a slash pine (Pinus elliottii Engelm. stand using images from both LISS-III/ResourceSat-1 and TM/Landsat 5 sensors, cross comparing their performances. Reflectance values from the four spectral bands considered equivalent for both sensors were compared regarding sensitivity to changes in timber volume. Trends were similar, with direct relationship in the near-infrared bands and inverse relationships in the visible and mid-infrared bands. Significant differences were only found in the equivalent band of green. Multiple linear regressions were used to select spectral bands that would better explain variations in timber volume. The best fit equations for each sensor were inverted to generate maps of timber volume, estimates which were compared at pixel and stand level. None of the scales showed significant differences between estimates generated from the two sensors. We concluded that LISS-III and TM have generally very similar performance for monitoring timber volume, and LISS-III could therefore be potentially used as a complement or substitute to Landsat series.

Restauration fonctionnelle du rachis : effet du niveau initial de douleur sur les performances des sujets lombalgiques chroniques

Science.gov (United States)

Caby, Isabelle; Olivier, N; Mendelek, F; Kheir, R Bou; Vanvelcenaher, J; Pelayo, P

2014-01-01

HISTORIQUE : La lombalgie chronique est une douleur lombaire persistante d’origine multifactorielle. Le niveau de douleur initial reste faiblement utilisé pour analyser et comparer les réponses des patients lombalgiques au programme de reconditionnement. OBJECTIFS : Apprécier et évaluer les réponses des sujets lombalgiques chroniques très douloureux à une prise en charge dynamique et intensive. MÉTHODOLOGIE : 144 sujets atteints de lombalgie chronique ont été inclus dans un programme de restauration fonctionnelle du rachis de 5 semaines. Les sujets ont été classés en deux groupes de niveau de douleur: un groupe atteint de douleur sévère (n = 28) et un groupe atteint de douleur légère à modérée (n = 106). L’ensemble des sujets ont bénéficié d’une prise en charge identique comprenant principalement de la kinésithérapie, de l’ergothérapie, du reconditionnement musculaire et cardio-vasculaire ainsi qu’un suivi psychologique. Les paramètres physiques (flexibilité, force musculaire) et psychologiques (qualité de vie) ont été mesurés avant (T0) et après le programme (T5sem). RÉSULTATS : L’ensemble des performances physiques et fonctionnelles des sujets très douloureux sont moins bonnes et le retentissement de la lombalgie sur la qualité de vie, pour ces mêmes sujets, est majoré à T0. Toutes les différences significatives constatées à T0 entre les deux groupes s’effacent à T5sem. CONCLUSIONS : Les sujets lombalgiques chroniques très douloureux répondent favorablement au programme dynamique et intensif. L’intensité douloureuse de la lombalgie n’aurait pas d’effet sur les réponses au programme. La restauration fonctionnelle du rachis apporterait aux sujets la possibilité de mieux gérer leur douleur quel que soit son niveau. PMID:25299476

Aspects épidémiologiques des accidents vasculaires cérébraux (AVC) aux urgences de l'institut de cardiologie d'Abidjan (ICA)

Science.gov (United States)

N'goran, Yves N'da Kouakou; Traore, Fatou; Tano, Micesse; Kramoh, Kouadio Euloge; Kakou, Jean-Baptiste Anzouan; Konin, Christophe; Kakou, Maurice Guikahue

2015-01-01

Introduction L'objectif de notre étude était de décrire les caractéristiques sociodémographiques et les Facteurs de Risque cardio-Vasculaires (FRV) des patients admis pour accidents vasculaires cérébraux (AVC) dans un service autre que celui de la neurologie. Méthodes Étude transversale rétrospective sur une période de 2 ans (janv. 2010 et déc. 2011), réalisée aux urgences de l'institut de cardiologie d'Abidjan. Résultats Il s'agissait de 176 adultes avec un âge moyen de 60 ans, une prédominance féminine. Les facteurs de risque majeurs retrouvés étaient l'hypertension artérielle dans 86,4% des cas, le diabète dans 11,4% des cas, le tabagisme dans 2,2% des cas. Les motifs de consultation étaient la perte de connaissance dans 36,4% des cas, l'hémiplégie dans 31,8% des cas, les céphalées dans 17,4% des cas, les vertiges dans 10,9% et les palpitations dans 2,2% des cas. La tension artérielle systolique moyenne était à 174 mmHg, la tension artérielle diastolique moyenne était à 105 mmHg et la pression pulsée moyenne était à 70 mmHg. Les AVC étaient associés à une arythmie complète par fibrillation auriculaire dans 11,4% des cas. Les AVC ischémiques représentaient 84,1%. L’évolution aux urgences a été marquée par un décès dans 17% (30) des cas. Conclusion Les AVC constituent un problème majeur de santé publique. Malgré sa prédominance féminine, ils (AVC) touchaient 44% des hommes dans notre étude lorsqu'on sait qu'en Afrique l'activité sociale repose sur les hommes. Ils restent une pathologie grave par la forte létalité. PMID:26327997

LISS: Planning for spin physics with multi-GeV nucleon beams at IUCF

International Nuclear Information System (INIS)

Vigdor, S.E.

1995-01-01

The technology developed in recent years to facilitate experiments with stored, cooled polarized beams bombarding internal targets (including polarized gaseous targets) has natural and novel applications at multi-GeV energies. At IUCF we are preparing a proposal for a Light-Ion Spin Synchrotron (LISS) that would adapt this technology to the exploration of nucleon spin physics in the non-perturbative QCD regime from 1 endash 20 GeV. I will describe the research goals of such a facility, with emphasis on a few contemplated experiments, chosen to illustrate both the range of physics issues to be addressed and the considerable advantages offered by storage ring techniques. copyright 1995 American Institute of Physics

ESTUDO COMPARATIVO ENTRE OS ÍNDICES NDVI OBTIDOS A PARTIR DOS SENSORES LANDSAT 5 - TM E RESOURCESAT - LISS III

Directory of Open Access Journals (Sweden)

Cesar Vinícius Mendes Nery

2013-07-01

Full Text Available A importância das imagens de sensoriamento remoto para o monitoramento da cobertura vegetal é algo inegável. Por mais de três décadas a série Landsat tem fornecido imagens da terra, porém a partir de novembro de 2011 o satélite interrompeu a disponibilização de suas imagens para o monitoramento ambiental. Uma das alternativas de imagens ao Landsat têm sido as imagens do sensor LISS III a bordo do satélite indiano Resourcesat 1. O presente trabalho tem como área de estudo o município de Janaúba, por estar em uma área de transição de dois biomas, e o mesmo tem por objetivo comparar os dois sensores, o sensor TM que se encontra a bordo do satélite Landsat 5 e o sensor LISS III a bordo do satélite Resourcesat 1. Para esse estudo comparativo as imagens foram adquiridas do site do Instituto Nacional de Pesquisas Espaciais (INPE e seus valores de níveis digitais (ND foram convertidos em reflectância com correção atmosférica utilizando o método de correção DOS. Amostras de pixels das imagens índice foram coletadas para o estudo de correlação e ajuste de uma equação linear por meio da técnica de regressão. Utilizando a equação ajustada foram gerados dois mapas temáticos de ambos os sensores, sendo os mesmos comparados pelo teste estatístico Kappa. Os resultados mostraram uma forte correlação entre os valores de NDVI (0,81, sendo possível o ajuste de uma equação linear que expresse a forma dessa relação. O sensor TM, superestimou os valores de NDVI em relação ao sensor LISS III (Inclinação de 1,1035. O valor de Kappa para os mapas temáticos obtidos foi de 0,5894 e o índice de acerto foi de 98,81%, o que mostra uma boa similaridade entre eles. O sensor LISS III pode ser perfeitamente utilizado como alternativa ao Landsat 5.

Case report

African Journals Online (AJOL)

ebutamanya

12 juin 2015 ... majeurs à l'encéphalopathie de Gayet Wernicke et la myélinolyse centropontine en passant par les complications cardiaques et musculaires striées. L'atteinte musculaire striée liée à l'hypokaliémie est rare au cours des vomissements gravidiques; elle doit donc faire rechercher d'autres causes. Elle peut ...

APPLICATION HYDRAULIQUE DE LA TECHNIQUE GRAPHIQUE DE BERGERON AUX ACCIDENTS VASCULAIRES CÉRÉBRAUX : LE COUP DE BÉLIER HYDRAULIQUE Á L’ORIGINE D’UNE CAVITATION ENGENDRANT UN PHÉNOMÈNE DE THIXOTROPIE. LE MIRACLE DE SAINT JANVIER : HYPOTHESE SUR L’ORIGINE DE L’HEMORRAGIE CEREBRALE DU SUJET HYPERTENDU.

OpenAIRE

Venet , Richard; Léger , Philippe; Pavie , Alain

2013-01-01

Un poète de l’entre deux guerres a décrit les circonstances de son accident vasculaire cérébral, nous évoquant « un coup de bélier hydraulique ». Pour Ahlqvist l’hémorragie cérébrale est secondaire à l’embolisation (occlusion instantanée) d’une artère cérébrale engendrant ainsi un coup de bélier responsable de la fissuration d’un micro-anévrisme de Charcot. Nous nous proposons dans cet article d’exposer le plus compendieusement possible la théorie du coup de bélier hydraulique. Appliquant cet...

Etude du point critique des paliers lisses alimentés à la graisse Study of Critical Point on Plain Bearings Lubricated by Grease

Directory of Open Access Journals (Sweden)

Delneuville P.

2006-11-01

Full Text Available Cet article est essentiellement consacré à l'étude du fonctionnement limite des paliers lisses lubrifiés à la graisse ; son but est de permettre la détermination des conditions nécessaires à l'obtention d'un film lubrifiant d'épaisseur suffisante. L'auteur cherche à cette occasion une loi théorique qui permet de départager les régimes de lubrification, non plus empiriquement, mais sur la base de lois statistiques. La formulation finale doit permettre aux utilisateurs de situer correctement les conditions de fonctionnement d'un palier lisse et d'en estimer la sécurité du régime. This article deals essentially with the boundary behaviour of plain bearings lubricated by grease. Its aim is to determine the conditions required to obtain a sufficiently thick lubricating film. The author proposes a theoretical law for separating lubrication types. This law is not empirical but is based on statistical laws. The final formulation should enable users to correctly situate the operating conditions of a plain bearing and to evaluate the safety factor during running.

Comment on “Comparison of the composition of the Tempel 1 ejecta to the dust in Comet C/Hale Bopp 1995 O1 and YSO HD 100546” by C.M. Lisse, K.E. Kraemer, J.A. Nuth III, A. Li, D. Joswiak [2007. Icarus 187, 69 86

Science.gov (United States)

Crovisier, Jacques; Bockelée-Morvan, Dominique

2008-06-01

Lisse et al. [Lisse, C.M., Kraemer, K.E., Nuth III, J.A., Li, A., Joswiak, D., 2007. Icarus 187, 69-86] recently presented a new analysis of an ISO spectrum of Comet C/1995 O1 (Hale-Bopp), from which they claimed the identification of many new dust species. Among them are PAHs, which were not found in our first analysis of the ISO spectra. We present here a re-examination of the ISO observations of Comet Hale-Bopp. From the absence of PAHs features in the 5.25-8.5 μm region, we infer that PAHs are at least twice less abundant than derived by Lisse et al. The carbonate feature at 7.00 μm is marginally present, but lower by a factor 2 to 3 than predicted by the model of Lisse et al.

Rebuttal to “Comment on the paper “Comparison of the composition of the Tempel 1 ejecta to the dust in Comet C/Hale Bopp 1995 O1 and YSO HD 100546” by C.M. Lisse, K.E. Kraemer, J.A. Nuth III, A. Li, and D. Joswiak"

Science.gov (United States)

Lisse, C. M.

2008-06-01

This response is to address the comments made by Drs. J. Crovisier and D. Bockelee-Morvan concerning the spectral analysis of Lisse et al. [Lisse, C.M., Kraemer, K.E., Nuth, J.A., Li, A., Joswiak, D., 2007. Icarus 187, 69-86] of the mid-IR ISO SWS spectrum of Comet Hale-Bopp 1995 O1 taken on October 6, 1996, and to support the conclusions made in Lisse et al. concerning the positive detection of PAHs in this comet. We also present some additional information determined from the Deep Impact and STARDUST missions, demonstrating the presence of PAHs in other comets, to support the plausibility of the Hale-Bopp PAH detection.

Estimation and Mapping Forest Attributes Using “k Nearest Neighbor” Method on IRS-P6 LISS III Satellite Image Data

Directory of Open Access Journals (Sweden)

Amir Eslam Bonyad

2015-06-01

Full Text Available In this study, we explored the utility of k Nearest Neighbor (kNN algorithm to integrate IRS-P6 LISS III satellite imagery data and ground inventory data for application in forest attributes (DBH, trees height, volume, basal area, density and forest cover type estimation and mapping. The ground inventory data was based on a systematic-random sampling grid and the numbers of sampling plots were 408 circular plots in a plantation in Guilan province, north of Iran. We concluded that kNN method was useful tool for mapping at a fine accuracy between 80% and 93.94%. Values of k between 5 and 8 seemed appropriate. The best distance metrics were found Euclidean, Fuzzy and Mahalanobis. Results showed that kNN was accurate enough for practical applicability for mapping forest areas.

Five-year outcome of a stroke cohort in Martinique, French West Indies: Etude Réalisée en Martinique et Centrée sur l'Incidence des Accidents vasculaires cérebraux, Part 2.

Science.gov (United States)

Chausson, Nicolas; Olindo, Stéphane; Cabre, Philippe; Saint-Vil, Martine; Smadja, Didier

2010-04-01

Limited information exists on stroke among black populations outside the United States and United Kingdom. Part 1 of the Etude Réalisée en Martinique et Centrée sur l'Incidence des Accidents vasculaires cérebraux (ERMANCIA) provided strong epidemiologic data on the incidence of first-ever stroke in a black Caribbean population and showed a 40% greater incidence of stroke in Martinique than in continental France. In ERMANCIA part 2, we evaluated the long-term outcomes of our cohort. Survivors of a first stroke from this prospective, community-based, stroke incidence study were reassessed at 5 years according to standardized procedures and criteria, including the modified Rankin scale, Barthel Index, Montgomery-Asberg Depression-Rating Scale, Mini-Mental State Examination, treatment compliance, and blood pressure control. Of the 293 survivors of the original 580 (50.5%) patients who were still alive 5 years after stroke, 262 (89.4%) were assessed. Among these survivors, 66.4% were functionally independent and 43% were completely autonomous for activities of daily living, but 25.8% were depressed and 58.9% were cognitively impaired. Only 50 of 170 (29.4%) of the hypertensive patients achieved their target blood pressure. These results highlight the very poor blood pressure control and the very high rate of cognitive impairment in Martinican patients after stroke. As a consequence, a poststroke prevention network was established in Martinique.

Mapping of sugarcane crop area in the Paraná State using Landsat/TM/OLI and IRS/LISS-3 images

Directory of Open Access Journals (Sweden)

Clóvis Cechim Junior

Full Text Available ABSTRACT The knowledge on reliable estimates of areas under sugarcane cultivation is essential for the Brazilian agribusiness, since it helps in the development of public policies, in determining prices by sugar mills to producers and allows establishing the logistics of production disposal. The objective of this work was to develop a methodology for mapping the sugarcane crop area in the state of Paraná, Brazil, using images from the Landsat/TM/OLI and IRS/LISS-3 satellites, for the crop years from 2010/2011 to 2013/2014. The mappings were conducted through the supervised Maximum likelihood classification (Maxver achieving, on average, an overall accuracy of 94.13% and kappa index of 0.82. The correlation with the official data of the IBGE ranged from moderate to strong (0.64 ≤ rs ≤ 0.80 with average agreement (dr of 0.81. There was an increase of 2.73% (18,630 ha in the area with sugarcane in Paraná between 2010/2011 and 2013/2014.

Investigating the Capability of IRS-P6-LISS IV Satellite Image for Pistachio Forests Density Mapping (case Study: Northeast of Iran)

Science.gov (United States)

Hoseini, F.; Darvishsefat, A. A.; Zargham, N.

2012-07-01

In order to investigate the capability of satellite images for Pistachio forests density mapping, IRS-P6-LISS IV data were analyzed in an area of 500 ha in Iran. After geometric correction, suitable training areas were determined based on fieldwork. Suitable spectral transformations like NDVI, PVI and PCA were performed. A ground truth map included of 34 plots (each plot 1 ha) were prepared. Hard and soft supervised classifications were performed with 5 density classes (0-5%, 5-10%, 10-15%, 15-20% and > 20%). Because of low separability of classes, some classes were merged and classifications were repeated with 3 classes. Finally, the highest overall accuracy and kappa coefficient of 70% and 0.44, respectively, were obtained with three classes (0-5%, 5-20%, and > 20%) by fuzzy classifier. Considering the low kappa value obtained, it could be concluded that the result of the classification was not desirable. Therefore, this approach is not appropriate for operational mapping of these valuable Pistachio forests.

ERS-2 SAR and IRS-1C LISS III data fusion: A PCA approach to improve remote sensing based geological interpretation

Science.gov (United States)

Pal, S. K.; Majumdar, T. J.; Bhattacharya, Amit K.

Fusion of optical and synthetic aperture radar data has been attempted in the present study for mapping of various lithologic units over a part of the Singhbhum Shear Zone (SSZ) and its surroundings. ERS-2 SAR data over the study area has been enhanced using Fast Fourier Transformation (FFT) based filtering approach, and also using Frost filtering technique. Both the enhanced SAR imagery have been then separately fused with histogram equalized IRS-1C LISS III image using Principal Component Analysis (PCA) technique. Later, Feature-oriented Principal Components Selection (FPCS) technique has been applied to generate False Color Composite (FCC) images, from which corresponding geological maps have been prepared. Finally, GIS techniques have been successfully used for change detection analysis in the lithological interpretation between the published geological map and the fusion based geological maps. In general, there is good agreement between these maps over a large portion of the study area. Based on the change detection studies, few areas could be identified which need attention for further detailed ground-based geological studies.

Maladie de Horton révélée par une dyspnée

Science.gov (United States)

Mahfoudhi, Madiha; Mamlouk, Habiba; Turki, Sami; Kheder, Adel

2015-01-01

Les manifestations pleuro-pulmonaires de la maladie de Horton sont rares et peu connues. Elles peuvent être inaugurales, à l'origine d'un retard à la prise en charge si elles sont méconnues. Il s'agissait d'un patient âgé de 75 ans, admis pour une dyspnée, une toux chronique et une fièvre. Il a reçu une antibiothérapie et a bénéficié d'une fibroscopie bronchique avec lavage broncho-alvéolaire à la recherche d'un germe, qui a révélé plutôt, une alvéolite lymphocytaire. L’évolution était marquée par la persistance des signes cliniques et du syndrome inflammatoire biologique. Un angio-scanner thoracique et une échographie cardiaque étaient sans anomalies. Une origine cardiaque, musculaire, hématologique, néoplasique, vasculaire ou métabolique de la dyspnée a été éliminée. Une maladie de Horton a été évoquée. La biopsie de l'artère temporale a confirmé le diagnostic d'une maladie de Horton. L’évolution sous corticothérapie était marquée par la disparition des signes cliniques et biologiques. Les manifestations pleuro-pulmonaires au cours de la maladie de Horton sont rares, et classiquement, rarement révélatrices de la maladie. La dyspnée peut initialement égarer le diagnostic vers d'autres étiologies notamment infectieuses. Le but de ce travail est d'insister sur le fait que la connaissance de ces différentes manifestations respiratoires au cours de la maladie de Horton (toux persistante, dyspnée, épanchement pleural) est utile au clinicien afin de prescrire une corticothérapie, chez un sujet le plus souvent âgé ayant un état fébrile et inflammatoire prolongé, permettant ainsi d’éviter l'apparition de complications. PMID:26161171

Case report

African Journals Online (AJOL)

ebutamanya

22 oct. 2015 ... Métastases musculaires squelettique asymptomatique d'un cancer bronchique non à petites cellules .... from lung cancer. Cancer. 1987; 59(8):1530-4. PubMed | ... apparent stage III non-small-cell lung cancer: implications for.

Intérêt pronostique de l’infiltration du chorion dans les tumeurs vésicales pT1

Directory of Open Access Journals (Sweden)

W. Zakhama

2016-12-01

Conclusion: Le classement des ces tumeurs en fonction de l’importance d’envahissement du chorion et de l’infiltration de la musculaire muqueuse a prouvé son efficacité à travers les taux de récidive et de progression tumorale chez nos malades.

African Journal of Neurological Sciences 2010 - Vol. 29, No 1 9 ...

African Journals Online (AJOL)

kim

REINTEGRATION COMMUNAUTAIRE POST-ACCIDENT VASCULAIRE CEREBRAL ... reorganization of physical, psychologic and social characteristics so that the ... community and distance mobility, self care, daily activity (work and school) ...

Tuméfaction du muscle pectoral révélant une tuberculose ...

African Journals Online (AJOL)

Abstract. La tuberculose des parties molles représente l'une des formes rares de la tuberculose extra pulmonaire, la localisation musculaire isolée est parailleurs exceptionnelle. ... We here report the original case of a young immunocompetent patient with isolated muscular tuberculosis involving major pectoralis muscle.

Original Paper Efficacité d'un produit répulsif à base de l ...

African Journals Online (AJOL)

L500

d'Anthranilate de Methyl ont été réalisés au champ, en station de recherche et au laboratoire. L'essai réalisé à ..... coagulation associés à une atrophie des fibres musculaires ... et c) une atteinte pulmonaire de type d'une pneumopathie.

angiofibrome nasopharyngien compliqué d'un syndrome de foster ...

African Journals Online (AJOL)

FACIALE. * SERVICE DE RADIOTHÉRAPIE. HÔPITAL UNIVERSITAIRE F. HACHED - SOUSSE. RESUME. L'angiofibrome nasopharyngien (FNP) est une tumeur vasculaire bénigne localement agressive. Il représente 0,05% des.

L'infection a virus de l'Immunodeficience Humaine (VIH), facteur ...

African Journals Online (AJOL)

L'infection a virus de l'Immunodeficience Humaine (VIH), facteur predictif de gravite et de mortalite des accidents vasculaires cerebraux au Centre National Hospitalier et Universitaire-Hubert Koutoukou Maga (CNHU-HKM) de Cotonou, Benin.

ASPECTS NUTRITIONNELS DES ACIDES GRAS TRANS : Consommation en acides gras trans et risque cardio-vasculaire : Étude Aquitaine

Directory of Open Access Journals (Sweden)

Combe Nicole

2000-01-01

Full Text Available Au cours de cette dernière décennie, les études sur la consommation d’acides gras trans (AGT se sont multipliées pour en préciser l’impact éventuel sur le risque de maladies cardio-vasculaires (MCV. À l’origine, se trouve l’étude américaine de Willett et al. [1], conduite sur une cohorte de 85 000 infirmières suivies pendant 8 ans. Cette étude épidémiologique rapportait l’existence d’une corrélation positive entre la consommation d’AGT d’origine végétale et l’apparition de MCV. Ont suivi d’autres études que l’on peut classer en trois catégories selon leur approche expérimentale : les études épidémiologiques [2-5] longitudinales ou transversales, les comparaisons « cas-témoins » [6-11] et les interventions nutritionnelles [12-15]. Des deux premières catégories d’études, il n’émerge aucun consensus quant à l’implication éventuelle des AGT alimentaires dans le risque de MCV. Les divergences observées pourraient, en partie tout au moins, être liées à la méthode utilisée pour estimer la consommation d’AGT qui, dans certains cas, est fondée sur des enquêtes alimentaires et, dans d’autres cas, sur la teneur en AGT du tissu adipeux des sujets, connue pour refléter l’apport alimentaire en AGT des années précédentes. En effet, au-delà de considérations sur de possibles biais méthodologiques [16], comme le non-ajustement des résultats à des facteurs de confusion tels que l’âge, la consommation de tabac ou certaines pathologies, on peut faire le constat suivant : les études qui ont conclu à un effet négatif des AGT alimentaires étaient fondées, pour la plupart, exclusivement sur des enquêtes alimentaires [1-3, 11] ; celles qui ne montraient aucun effet utilisaient, le plus souvent, la composition en AGT du tissu adipeux [4, 6-9]. La carence, dans les bases de données, vis-à-vis des teneurs en AGT des aliments augmente, en outre, la difficulté à déterminer la

Role of Transglutaminase 2 in vascular remodeling

NARCIS (Netherlands)

van den Akker, H.H.O.

2011-01-01

Verschillende vasculaire ziektebeelden, waaronder hoge bloeddruk en verminderde doorbloeding, leiden tot vernauwing van slagadertjes. Het enzym Transglutaminase 2 (TG2) speelt hierbij een belangrijke rol. Jeroen van den Akker onderzocht het achterliggende proces en ontdekte een nieuwe activatieroute

Monitoring Environment with GIS for Part of Thiruvallur Town Using Cartosat 1 Stereo, Pan & Resourcesat Liss 4 MSS Merged Data

Science.gov (United States)

Mohamed, G. S.; Venkatchalam, R. V.; Ramamurthhy, M.; Gummidipoondi, R. J.; Ramillah, M.

2012-07-01

Thiruvallur town is about 44 km from Chennai in Tamil nadu state of India with a population of 130000 , covering 10.75 sq km area. It is about 2km from Sri Venkateswara College of Engineering and Technology. It was Taluk (Sub Division'.s) head quarters and from 1991 it was upgraded as District head quarters after the formation of Thiruvallur District. With rapid growth of town the Population density of Thiruvallur has increased in the past three decades from 300 persons/sq.km in 1951, to 6000 persons/sq.km in 1981 and now it is 12925 persons/sq.km in 2011. The creation of District administrative collector office, headquarters offices for police, judicial courts and Tamil Nadu and Federal Government development department's offices, establishment of multinationals major industries like Caterpillar, Kingfishers,Hindustan Motors, Mahendra Automobiles, Coco cola, Japanese Glass industry, Korean LOTO etc apart from mushrooming growth of about 41 Engineering, Nursing, Education, Medical, Naval, Arts and Science colleges, International Public schools,Governmentt, Private schools and Polytechnics added to the population of this Town. It is well connected by National Highways and Railways and upgraded as District Municipality. This resulted in urban drainage problem and conversion of Agriculture land and lakes for housing, establishment of major Govt and Private Hospitals including special units for Eye care, Cardiology, and Health Clinics, pharmacies etc. The effect of urbanization on environment of this once silent rural temple town which was supporting intensive agriculture activities , green with paddy fields is studied with high resolution satellite data is know the impact on health and environment changes from 2008 to 2011, using 2.5m resolution PAN stereo data of Cartosat 1 merged with 5.8 m resolution Multi Spectral data of LISS 4 of Resourcesat 1 of Indian Remote sensing satellites and Geo Eye satellite image of 2011 from Google Earth web site for the western part

Research

African Journals Online (AJOL)

abp

6 nov. 2013 ... Résultats: sur un total de 4587 accouchements, 62 cas d'éclampsie étaient enregistrés .... coagulation intra-vasculaire disséminée et la survenue de .... Lopez-Llera, M. Main clinical types and subtypes of eclampsia.

Images in medicine

African Journals Online (AJOL)

ebutamanya

12 mai 2015 ... Le torticolis est une contracture d'un ou de plusieurs muscle(s) du cou. Il se manifeste par un tableau plus ou moins douloureux associant inclinaison de la tête du côté atteint, translation et rotation du côté sain. Les étiologies sont nombreuses. Leur gravité est variable, incluant des pathologies musculaires, ...

Case series

African Journals Online (AJOL)

ebutamanya

9 juin 2008 ... longtemps débattue, après avoir proposé initialement une origine musculaire striée les études récentes sont en faveur d'une origine neurogène schwannienne confirmées par une étude immunohistochimique. Le traitement de la tumeur à cellules granuleuses est un traitement chirurgical, il permet un ...

Neutron Activation for Studying Hydroelectrolytic Disorders in Child Pathology; Application de l'Activation Neutronique a l'Etude des Troubles Hydroelectrolytiques en Pathologie Infantile

Energy Technology Data Exchange (ETDEWEB)

Dubois, J. [Hopital Universitaire St-Pierre, Bruxelles (Belgium); Colard, J. [Centre d' Etude de l' Energie Nucleaire, Mol (Belgium); Vis, H. L. [Institut pour la Recherche Scientifique en Afrique Centrale, Bukavu (Congo, The Democratic Republic of the)

1967-10-15

The authors describe a method of determining electrolytes (Na, K, CI) and phosphorus in small fragments of muscle taken from child patients by needle biopsy. This method has been used to study muscular disturbances in hydroelectrolytic illnesses of childhood, whether acute, such as dehydration or toxicosis in infants, or chronic, such as malnutrition or marasmus. The results are discussed in the light of parallel data obtained by other methods of investigation. The authors also discuss the possibility of using this method to estimate intra-cellular hydroelectrolytic disorders in child pathology. (author) [French] Les auteurs presentent la description d'une methode permettant le dosage des electrolytes (Na, K, Cl) et du phosphore sur de petits fragments musculaires preleves par ponction-biopsie chez l'enfant. Cette methode a ete appliquee a l'etude des perturbations du milieu musculaire dans des troubles hydroelectrolytiques aigus (deshydratation et toxicose des nourrissons) et chroniques (malnutrition et denutrition) de l'enfance. Les resultats obtenus sont discutes a la lumiere de donnees recueillies parallelement par d'autres methodes d'investigation. Les auteurs discutent egalement la possibilite d'estimer par cette methode les perturbations hydroelectrolytiques intra-cellulaires en pathologie pediatrique. (author)

Perceived classism and its relation with socioeconomic status, health, health behaviours and perceived inferiority: the Dutch Longitudinal Internet Studies for the Social Sciences (LISS) panel.

Science.gov (United States)

Simons, Audrey M W; Koster, Annemarie; Groffen, Daniëlle A I; Bosma, Hans

2017-05-01

Classism might be the downside of the prevailing ideologies of individual responsibility for success. However, since studies into perceived classism have mainly been qualitative, little is known about its association with socioeconomic status, health, health behaviours and perceived inferiority, especially in more egalitarian countries. This study, therefore, examined the associations of perceived classism with socioeconomic status, health, health behaviours and perceived inferiority. We used cross-sectional data (2012/2013) from the Dutch Longitudinal Internet Studies for the Social Sciences (LISS) (n = 1540; age 16-90; 46.9 % men). We found that classism was perceived by 18.2 % of the participants, with the lowest income and occupation group most likely to perceive classism (22.0 and 27.5 %, respectively). Perceived classism was significantly associated with poor health (e.g. self-rated health OR = 2.44, 95 % CI = 1.76-3.38) and feelings of inferiority (e.g. shame OR = 4.64, 95 % CI = 3.08-6.98). No significant associations were found with health behaviours. To further examine the role of perceived classism for socioeconomic differences in health and its association with country-level socioeconomic inequalities, prevailing ideologies, and objective opportunities for social mobility, we recommend more longitudinal and international studies with comparable measures of perceived classism.

Browse Title Index

African Journals Online (AJOL)

zemidjan" de la ville de Porto-Novo (Benin). Abstract. B Akplogan, MM Lawani, AD Fanou. Vol 15, No 2 (2013): Series A,B,D,E, La surveillance des abords vasculaires chez les hémodialysés chroniques à l'Hôpital National de Lamordé Niamey ...

Fuelling Economic Growth: The Role of Public–Private Sector ...

International Development Research Centre (IDRC) Digital Library (Canada)

26 avr. 2009 ... ... in the environment for research and development (R&D) around the world. ... It addresses trends in funding, performance, and management of R&D ... Michael Graham is a specialist in development communication, evaluation, and science ... et comptent pour près des deux tiers des accidents vasculaires.

Research

African Journals Online (AJOL)

abp

24 juin 2015 ... Page number not for citation purposes. 1. Epaisseur de l'intima-média carotidienne et facteurs de risque cardio-vasculaires. Nicolas Fanantenana Herinirina1, Lova Hasina Ny Ony Narindra Rajaonarison2,&, Andry Roussel Herijoelison3, Ahmad Ahmad2. 1Service Imagerie Médicale, Centre Hospitalier ...

2299-IJBCS-Article-Roger Niebié

African Journals Online (AJOL)

hp

1Département Substances Naturelles/IRSAT/CNRST, 03 BP 7047 Ouagadougou 03, Burkina Faso. 2 Laboratoire de Chimie Organique et de ... 2000) ainsi que les risques de maladies cardio- vasculaires (Riccioni, 2009). La production ... obtenus par séchage naturel à l'ombre au laboratoire pendant sept (07) jours, soit à.

Images in medicine

African Journals Online (AJOL)

abp

6 nov. 2013 ... clinique à type de thromboangéite oblitérante, des lésions très distales, une atteinte ... d'amputation, mais les problèmes de tolérance et de coût limitent ... vasculaires, le dosage des facteurs de coagulation et les examens.

Case report

African Journals Online (AJOL)

raoul

28 août 2011 ... préeclamptiques admises durant la période d'étude est de 1,49 %. Aucune .... consécutif au développement d'une coagulation intra vasculaire disséminée. ... aura vraisemblablement dans l'avenir sa place dans ce type de.

Trends in incidence and early outcomes in a Black Afro-Caribbean population from 1999 to 2012: Etude Réalisée en Martinique et Centrée sur l'Incidence des Accidents Vasculaires Cérébraux II Study.

Science.gov (United States)

Olindo, Stephane; Chausson, Nicolas; Mejdoubi, Mehdi; Jeannin, Severine; Rosillette, Karine; Saint-Vil, Martine; Signate, Aissatou; Edimonana-Kaptue, Mireille; Larraillet, Veronique; Cabre, Philippe; Smadja, Didier; Joux, Julien

2014-11-01

Seldom studies are available on trends in stroke incidence in blacks. We aimed to evaluate whether stroke risk prevention policies modified first-ever stroke incidence and outcomes in the black Afro-Caribbean population of Martinique. Etude Réalisée en Martinique et Centrée sur l'Incidence des Accidents Vasculaires Cérébraux (ERMANCIA) I and II are 2 sequential prospective population-based epidemiological studies. There have assessed temporal trends in first-ever stroke incidence, risk factors, pathological types, and early outcomes in the black Afro-Caribbean population of Martinique comparing two 12-month periods (1998-1999 and 2011-2012). Crude and age-standardized incidence and 30-day outcomes for stroke in the 2 study periods were compared using Poisson regression. We identified 580 and 544 first-ever strokes in the 2 studies. World age-standardized incidence rates decreased by 30.6% in overall (111 [95% confidence interval, 102-120] versus 77 [95% confidence interval, 70-84]). Rate decline was greater in women than in men (34% versus 26%) particularly in women aged 65 to 74 years (-69%) and 75 to 84 years (-43%). Frequencies of hypertension and diabetes mellitus were unchanged, whereas dyslipidemia, smoking, and atrial fibrillation significantly increased. Only ischemic stroke types showed significant rate reduction in overall and in women, incidence rate ratio (95% confidence intervals) of 0.69 (0.50-0.97) and 0.61 (0.42-0.88), respectively. The overall 30-day case-fatality ratio remained stable (19.3%/17.6%), whereas a better 30-day outcome was found (modified Rankin Score, ≤2 in 47%/37.6%; P=0.03). Over 13 years, there has been a significant decrease (30.6%) in the age-specific first-ever stroke incidence in our Afro-Carribean population. Although prevention policies seem effective, we need to focus on new risk factors limitation and on male population adherence to prevention program. © 2014 American Heart Association, Inc.

Epidemiologie des accidents vasculaires cerebraux dans la ...

African Journals Online (AJOL)

ischemic; 45, 2% were haemorrhagic and 10, 8 % were meningeal bleeding. The main risk factors were high blood pressure (87, 3%), diabetes (17, 5%), hypercholesterolemia (4, 2%), irregular heart rate (4,2%). Hospital length stay average was 17 days with 8, 5 SD. Mortality rate was 27, 5%. This represented 7, 8% of all ...

Author Details

African Journals Online (AJOL)

Ngouma, Amour. Vol 36, No 1 (2017) - Articles Depression chez l'hemiplegique vasculaire a Brazzaville Abstract. ISSN: 1015-8618. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL ...

Pneumonie organisée révélatrice d'une polymyosite

Science.gov (United States)

Ben Saad, Ahmed; Joobeur, Samah; Rouetbi, Naceur; Mhamed, Saousen Cheikh; Skhiri, Néji; Mribah, Hathami; El Kamel, Ali

2014-01-01

Les polymyosites (PM) sont des connectivites très rares, d’étiologie inconnue, dotées d'un grand polymorphisme clinique et évolutif. Elles peuvent être associées à d'autres manifestations viscérales notamment pulmonaires telles que la pneumopathie interstitielle. Ces complications respiratoires sont souvent associées à un taux de mortalité élevé. Les cas de pneumonie organisée révélatrice de polymyosite sont rarement rapportés dans la littérature et de description récente. Nous rapportons l'observation d'une patiente âgée de 53 ans qui a présenté, 14 mois après avoir porter le diagnostic d'une pneumonie organisée, des myalgies diffuses, un ‘dème des membres inférieurs et une élévation des enzymes musculaires. La biopsie musculaire a confirmé le diagnostic de la myosite. L’évolution était favorable sous corticothérapie. Le traitement de la PO associée au PM n'est pas clairement établi. La corticothérapie constitue le traitement de première intention. PMID:25722789

Ventricule droit à double chambre (VDDC) isolé: à propos d'un cas ...

African Journals Online (AJOL)

Nous rapportons l'observation d'une adolescente de 16 ans, présentant une forme isolée de VDDC révélée par des syncopes à répétition. Le diagnostic est fait par l'échocardiographie Döppler. La résection chirurgicale de la bande musculaire anormale a été faite avec succès. Mots clés: VDDC, adolescente, syncope, ...

Case series

African Journals Online (AJOL)

ebutamanya

autres causes d'hémorragies ont été décrites. Il s'agit de: une blessure ou un embrochage du foie par un écarteur ou un instrument; une plaie vasculaire; un mauvais contrôle de l'artère cystique ou un mauvais décollement de la ...

Research

African Journals Online (AJOL)

abp

29 avr. 2016 ... Mots clés: Accident vasculaire cérébrale, doppler transcrânien, drépanocytose, enfant. Received: 17/05/2015 - Accepted: 07/03/2016 - Published: ... original work is properly cited. Pan African Medical Journal – ISSN: 1937- 8688 ..... Aracaju, Northeast-Brazil. Arq Neuropsiquiatr. 2008 Jun; 66(2):. 360-4.

Original Paper Evaluation de la fonction rénale chez les patients ...

African Journals Online (AJOL)

Evaluation de la fonction rénale chez les patients atteints de maladie cardio vasculaire (MCV) : comparaison entre ... Mots clés : Cystatine C, créatinine, insuffisance rénale, débit de filtration glomérulaire, maladies cardiovasculaires. Evaluation of the ... L'insuffisance rénale chronique (IRC) et les maladies cardiovasculaires ...

Author Details

African Journals Online (AJOL)

Touré, Kamadore. Vol 31, No 1 (2012) - Articles Infirmite motrice d'origine cerebrale : une serie Senegalaise Abstract PDF · Vol 32, No 2 (2013) - Articles Qualite de vie apres un accident vasculaire cerebral au Senegal: a propos de 50 cas. Abstract PDF · Vol 32, No 2 (2013) - Articles Selective attention of students suffering ...

Author Details

African Journals Online (AJOL)

Maladie de Krabbe : a propos d'un cas. Abstract PDF · Vol 32, No 2 (2013) - Articles Qualite de vie apres un accident vasculaire cerebral au Senegal: a propos de 50 cas. Abstract PDF · Vol 32, No 2 (2013) - Articles Selective attention of students suffering from primary headaches in a pain free period: a case control study

Vasculopathie artérielle dans la sclérodermie systémique. Caractéristiques micro- et macrovasculaire de l’angioscanner des artères des membres supérieurs

NARCIS (Netherlands)

Emad, Y.; Al-Sherbeni, H.; Ragab, Y.; Abo-El-Youn, I.; El Shaarawy, Nashwa; Nassar, D.Y.; Fathy, Ahmed; Al-Hanafi, H.; Rasker, Johannes J.

2015-01-01

Objectifs Décrire les résultats de l’angioscanner de la vasculopathie artérielle des gros vaisseaux ainsi que des petits et moyens vaisseaux de l’ensemble de l’arbre vasculaire des membres supérieurs chez les patients porteurs d’une sclérodermie systémique (ScS) avec ou sans ulcération digitale.

No 129-L'exercice physique pendant la grossesse et le postpartum.

Science.gov (United States)

Davies, Gregory A L; Wolfe, Larry A; Mottola, Michelle F; MacKinnon, Catherine

2018-02-01

Énoncer une directive canadienne visant à informer les fournisseurs de soins obstétricaux des répercussions, pour la mère, le fœtus et le nouveau-né, des exercices de conditionnement aerobique et musculaire pendant la grossesse. RéSULTATS ATTENDUS: Effets sur la morbidité maternelle, fœtale et néonatale et mesures de la forme physique maternelle. Une recherche sur MEDLINE des articles, publiés en anglais de 1966 à 2002, appartenant aux catégories suivantes : études sur le conditionnement aérobique et musculaire chez des femmes ne faisant pas jusque-là d'exercice et chez des femmes actives avant leur grossesse, ainsi que des études sur les répercussions du conditionnement aérobique et musculaire sur les issues précoces et tardives de la grossesse ou sur les issues néonatales; rapports de synthèse et méta-analyses portant sur l'exercice pendant la grossesse. Les résultats recueillis ont été revus par la Société des obstétriciens et gynécologues du Canada (Comité de la pratique clinique - obstétrique), avec la participation de la Société canadienne de physiologie de l'exercice, et ils ont été classés suivant les critères d'évaluation des preuves établis par le Groupe de travail canadien sur l'examen de santé périodique. VALIDATION: Cette directive a été approuvée par le Comité de pratique clinique - obstétrique de la SOGC, par le Comité exécutif et par le Conseil de la SOGC, ainsi que par le Conseil d'administration de la Société canadienne de physiologie de l'exercice. PARRAINé PAR: la Société des obstétriciens et gynécologues du Canada et par la Société canadienne de physiologie de l'exercice. Copyright © 2018. Published by Elsevier Inc.

prise en charge tardive des sequelles de fractures du plancher

African Journals Online (AJOL)

19 déc. 2007 ... d'abord adaptées, libération du foyer de fracture de la péri orbite et des ailerons musculaires, réduction des frag- ments osseux déplacés et contention par ostéosynthèse au fil d'acier ou par plaques vissées (7, 8,9), comblement des défects osseux par greffes osseuses ou implants, et correction des lésions ...

Prise en charge et surveillance d'une exostose solitaire du fémur ...

African Journals Online (AJOL)

L'exostose solitaire est une affection bénigne touchant l'enfant et les adultes. Son diagnostic est clinique, aidé par les examens radiologiques. Le traitement est chirurgical et consiste en son exérèse afin d'éviter les complications de compression vasculaire, ou de dégénérescence sarcomateuse. Nous rapportons ici le cas ...

Case series

African Journals Online (AJOL)

raoul

18 janv. 2012 ... d'asthme, d'une affection cardiaque préexistante (valvulopathie ou une autre atteinte), de prise d'anorexigènes. Nous avons en outre apprécié les données cliniques (dont les signes fonctionnels cardio-vasculaires, dermatologiques), les signes généraux (constantes hémodynamiques, état général), les ...

Envenimation scorpionique compliqué d'un accident vasculaire ...

African Journals Online (AJOL)

Les piqûres de scorpion sont dans un certain nombre de pays, un accident fréquemment rencontré, et un risque grave. Au Maroc, les données épidémiologiques établies par le centre anti-poison (CAPM) montrent que les piqûres scorpioniques se placent en tête de toutes les intoxications relevées par le centre (60%).

Depression chez l'hemiplegique vasculaire a Brazzaville | Ossou ...

African Journals Online (AJOL)

L'évolution à 6 mois n'a pas été favorable chez 65,7 % des patients. ... Sa prise en charge permettrait assurément d'améliorer la qualité de vie des patients, ... The management of post-stroke depression certainly improves the quality of life of ...

Malformations vasculaires au cours du syndrome de Williams ...

African Journals Online (AJOL)

Le syndrome de Williams-Beuren est une maladie génétique rare, il associe classiquement une dysmorphie faciale assez spécifique, des malformations cardiovasculaires et un profil neuropsychologique particulier. Nous rapportons les observations de trois enfants atteints du syndrome de Williams-Beuren en insistant ...

EVALUATION OF CATROSAT 1PAN STEREO AND RESOURCESAT LISS 4 MSS MERGED DATA FOR MORPHOMETRIC ANALYSIS, DELINEATION OF DRAINAGE BASINS AND CODIFICATION IN TAMIL NADU, INDIA AND AUSTRALIA

Directory of Open Access Journals (Sweden)

G. S. Mohamed

2012-07-01

Full Text Available The Topographic maps and Aerial Photographs are used for morphometric analysis of drainage basins and mapping contours with drainage. The stereo pairs of 2.5 m resolution Cartosat 1, Indian satellite 2 and merged data with 5.5 m resolution P6 Resourcesat 1 LISS 4 Indian satellite of 2001 is used to map, rills, gullies, and streams of first order to evaluate part of drainage basin of Cooum and Poondi Reservoir in Thiruvallur taluk of Tamil Nadu state. The Geo Eye latest 2011data is also used with Catrosat 1Stereo data to study present morphology of tiny micro watersheds to study the use of High resolution data for delineation and codification of watersheds. This study area is in an inter fluvial drainage basin of Cooum and Kusasthalai rivers. Kusasthalai river drains in Poondi reservoir which is about 50 km from Chennai. The excess water from Kosasthalai is also diverted through Kesawaram weir to Cooum river which passes through Thiruvallur and Chennai city before it's confluence with Bay of Benegal in the east. As Cooum basin is at higher elevation, water for irrigation is again diverted through chain of tanks to Kusasthalai river basin to drain in Poondi reservoir. Delineation of water sheds in this fluvial basin is difficult by manual survey as man made irrigation channels, natural drainage streams etc., have to be clearly identified. The streams of various orders are identified based on Strahler stream order hierarchy of tributaries, slops and contours using large scale satellite data. The micro water sheds are delinated identifying the ridges from Catrosat data for this interfluves basin which has mild slop. To illustrate this research, parts of two micro watersheds which were delineated using 1:50000 data for Tamil Nadu watershed Atlas up to 7th order streams are taken up for a detailed study using high resolution data. 19 Micro watersheds with streams up to 10th order are mapped. The capability of high resolution satellite data for digital

Contenu de la fréquence de l'E.E.G. en fonction de l'effort physique et mental chez des malades présentant une insuffisance cérébrovasculaire (Communication préliminaire)

NARCIS (Netherlands)

Troost, J.; Kamp, A.; Kamphuisen, A.H.C.; Storm van Leeuwen, W.

Le contenu de la fréquence de l'E.E.G. en fonction de l'effort physique et mental chez des malades présentant une insuffisance cérébro-vasculaire (une communication préalable). La méthode consiste en une analyse spectrale digitale de l'E.E.G., qui est enregistré à l'aide d'un système

2185-IJBCS-Article-Aduayi-Akue Adote

African Journals Online (AJOL)

hp

différentes parties de l'organisme humain en entraînant des effets chroniques ou aigus sur la santé de l'homme (Were et al., 2008). La pollution par les métaux ... de certaines maladies liées à la contamination aux métaux lourds telles que les affections du foie et des reins, les maladies cardio- vasculaires, les cancers, la ...

Hematome organise du sinus maxillaire a propos d'un cas | Beltaief ...

African Journals Online (AJOL)

L'hématome organisé du sinus maxillaire est une entité rare. Son étiopathogénie reste incertaine. Nous rapportons le cas d'une patiente âgée de 16 ans présentant une épistaxis unilatérale droite de grande abondance avec une endoscopie nasale strictement normale. L'imagerie était en faveur d'une tumeur vasculaire du ...

Mise au point

African Journals Online (AJOL)

7 mai 2012 ... butyl-cyanoacrylate en ponction directe intra-lésionnelle. (10,17), ou en double approche (endo-vasculaire et trans- osseuse) (18,19, 20,21). La plupart des auteurs s'accordent sur le fait que l'alcool ne doit pas être utilisé dans les MAv des maxillaires (6,. 22, 23,24). en effet, injecté en intra-artériel, il donne ...

The maternal venous system: the ugly duckling of obstetrics

OpenAIRE

Tomsin, Kathleen

2013-01-01

Zowel de maternale vasculaire tonus als de hartfunctie tijdens zwangerschap worden beschouwd als cruciale factoren in de uitkomst van zowel moeder als kind. In dit complex verhaal van maternale hemodynamiek, hetgeen intens beschreven wordt in de huidige wetenschappelijke literatuur, wordt de rol van de maternale venen desalniettemin sterk onderschat. Tijdens deze thesis ontwikkelden en evalueerden wij een set van meetbare, objectieve parameters die een indicatie zijn voor veneuze functie, nam...

Traumatismes iatrogènes de l'artère fémorale secondaire à la pose ...

African Journals Online (AJOL)

Le recours aux cathéters veineux centraux (CVC) est incontournable en hémodialyse. Comparé aux autres abords vasculaires, il est pourtant associé à une morbidité et une mortalité plus élevées. Selon une étude menée par El Minshawy et coll, l'atteinte de l'artère fémorale représente 5% de ces complications. Nous en ...

Case report

African Journals Online (AJOL)

ebutamanya

1 oct. 2015 ... Les troubles de l'hémostase secondaires à une LV ou à un SAM sont fréquents, mais la survenue d'une coagulation intra-vasculaire disséminée (CIVD) est peu rapportée [3, 4]. Le traitement de la LV par Glucantime® peut être responsable de plusieurs effets indésirables ; la survenue d'une pancréatite est ...

نظام التغدية وعوامله التقافية والإجتماعية

OpenAIRE

BEKHCHI Mohamed

2013-01-01

La disparition de certaines maladies, demeure liée à l’évolution technologique et alimentaire, cependant, ce changement, de notre mode de vie, accompagnant, une industrialisation, et un changement culturel ont influencés notre alimentation conduisant ainsi l’apparition, de l’obésité et ses complications cardiaques, vasculaires et donc, l’excès de prise alimentaire, associant une limitation de l’exercice physique constituant un dang...

Prevalence de l'infection a VIH chez les patients victimes d'un ...

African Journals Online (AJOL)

Introduction: Le VIH/SIDA et son traitement antirétroviral sont associés à un risque élevé de maladies cardiovasculaires comme les accidents vasculaires cérébraux (AVC). L'objectif de cette étude était d'estimer la prévalence du VIH et d'identifier ses facteurs associés chez les patients hospitalisés pour un AVC. Méthode: ...

Case report

African Journals Online (AJOL)

abp

19 févr. 2013 ... trimestre, diagnostiqué à un stade tardif ainsi que les limites de la prise en charge en milieu sous équipé. Patient et observation. Il s'agit d'une gestante âgée de ... L'accouchement peut entraîner un risque d'emboles vasculaires et de dissémination. Après une vulvéctomie, un accouchement par voie basse ...

Syndrome de Sturge-Weber : A propos d'un cas a Lome. | Adigo ...

African Journals Online (AJOL)

Le syndrome de Sturge-Weber est une rare maladie congénitale, sporadique et non héréditaire. Il implique des malformations vasculaires de la peau (angiome cutané plan), des yeux et du cerveau (angiome leptoméningé). Les auteurs rapportent un cas révélé à l'âge adulte et dont le traitement a été médical ...

Les objectifs et les critères de sélection. Les aptitudes bouchères : croissance, efficacité alimentaire et qualité de la carcasse

OpenAIRE

SELLIER, Pierre; BOUIX, J.; Renand, Gilles; MOLENAT, M.

1992-01-01

Les programmes de sélection sur les aptitudes bouchères ont un double objectif : l’abaissement du coût de production et l’amélioration de la qualité du produit. Cet article rappelle un certain nombre de données de base sur les aptitudes bouchères : courbe de croissance, évolution de la composition chimique et tissulaire chez l’animal en croissance (notion d’allométrie), énergétique de la croissance (relation entre efficacité alimentaire et croissance musculaire), développement des tissus musc...

Une complication musculaire rarissime de l'hémophilie: la myosite ...

African Journals Online (AJOL)

Circumscribed myositis ossificans is a benign condition characterized by heterotopic growth of bone in soft tissues. It usually occurs in adolescents or young adults. Very rare cases have been described among children. Its etiopathogenesis is not clear, however, it seems that a focal muscle necrosis or a hematoma may ...

Case series

African Journals Online (AJOL)

abp

14 janv. 2013 ... actuel, l'âge avancé à la mise en hémodialyse, le sexe féminin, l'excès pondéral, et l'abord vasculaire. Le SCC est une complication fréquente de l'hémodialyse chronique. L'amélioration de la qualité de dialyse permettrait de réduire le risque de survenue du SCC. Pan African Medical Journal. 2013 ...

Le syndrome du canal carpien chez les patients hémodialysés ...

African Journals Online (AJOL)

La comparaison statistique entre les deux groupes de patients avec et sans SCC a démontré que la survenue de ce syndrome est liée à: l'âge actuel, l'âge avancé à la mise en hémodialyse, le sexe féminin, l'excès pondéral, et l'abord vasculaire. Le SCC est une complication fréquente de l'hémodialyse chronique.

Case series

African Journals Online (AJOL)

abp

19 sept. 2013 ... La durée moyenne d'hémodialyse était de 89± 54 mois. 67(80%) de nos patients étaient de bas niveau socio-économique. La néphropathie causale était diabétique dans 17.8% des cas, vasculaire dans 9.6% des cas, et indéterminée dans 53.3 %. (Figure 1). Les douleurs osseuses étaient présentes chez ...

Pérou : tous les projets | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Les régimes à teneur élevée en sel sont une cause majeure de l'hypertension artérielle et un facteur prédominant des décès, et comptent pour près des deux tiers des accidents vasculaires cérébraux et de la moitié des incidents de maladie cardiaque dans le monde. Région: Argentina, Brazil, Costa Rica, Paraguay, Peru.

Promouvoir des systèmes alimentaires sains

International Development Research Centre (IDRC) Digital Library (Canada)

fdieudonne

d'hypertension, de maladie cardiaque, de diabète et d'accidents vasculaires cérébraux. Le CRDI contribut aux efforts déployés pour réduire la consommation de sel, de sucre et de gras : Au Costa Rica, des objectifs de réduction de la consommation de sel ont été établis en s'appuyant sur les résultats de la recherche.

Peru : tous les projets | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Les régimes à teneur élevée en sel sont une cause majeure de l'hypertension artérielle et un facteur prédominant des décès, et comptent pour près des deux tiers des accidents vasculaires cérébraux et de la moitié des incidents de maladie cardiaque dans le monde. Région: Argentina, Brazil, Costa Rica, Paraguay, Peru.

Brazil : tous les projets | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Les régimes à teneur élevée en sel sont une cause majeure de l'hypertension artérielle et un facteur prédominant des décès, et comptent pour près des deux tiers des accidents vasculaires cérébraux et de la moitié des incidents de maladie cardiaque dans le monde. Région: Argentina, Brazil, Costa Rica, Paraguay, Peru.

Faible taux de succes du sevrage tabagique a court et moyen termes au decours d�un infarctus aigu du myocarde dans un service de cardiologie de Dakar au Senegal

Directory of Open Access Journals (Sweden)

Alassane Mbaye

2011-10-01

Full Text Available e le tabac pendant l�hospitalisation. Apres un suivi de 3 mois, 45% des patients ont repris le tabac, 65% a 6 mois et 85% a 12 mois. CONCLUSION: Le tabagisme est assez frequent chez les patients senegalais presentant un infarctus du myocarde. Le taux de sevrage tabagique a court et moyen termes est faible. Le sevrage tabagique devrait alors constituer un objectif privilegie dans la prevention des maladies cardio-vasculaires.

Traumatisme insolite de la région temporale | Lmekki | Journal ...

African Journals Online (AJOL)

Un homme âgé de 37ans était victime d'une agression par coup de couteau. Le patient se présente aux urgences le couteau fiché dans la région temporale sans symptomatologie clinique particulière et avec un score de Glasgow à 15. Le bilan lésionnel n'a pas objectivé d'atteinte vasculaire. Le retrait du couteau a été ...

Research

African Journals Online (AJOL)

ebutamanya

28 avr. 2016 ... L'objectif de ce travail était de déterminer la proportion des AVC du sujet jeune, les facteurs de risque cérébro- vasculaire (FRCV) et de rechercher les facteurs prédictifs de .... utilisée était non probabiliste basée sur le recrutement consécutif des dossiers obéissant aux critères d'éligibilité. Les données.

Liban | CRDI - Centre de recherches pour le développement ...

International Development Research Centre (IDRC) Digital Library (Canada)

Nous avons également appuyé la lutte antitabac afin de réduire les risques, entre autres, de cancer, de diabète et d'accidents vasculaires cérébraux. Une étude menée auprès des utilisateurs du narguilé, ou pipe à eau, qui sont très nombreux au Moyen-Orient, a donné lieu à des résultats inédits. Des chercheurs de ...

Outcome analysis of retrograde nailing and less invasive stabilization system in distal femoral fractures: A retrospective analysis

Directory of Open Access Journals (Sweden)

Christian Hierholzer

2011-01-01

Full Text Available Background: Two major therapeutic principles can be employed for the treatment of distal femoral fractures: retrograde intramedullary (IM nailing (RN or less invasive stabilization on system (LISS. Both operative stabilizing systems follow the principle of biological osteosynthesis. IM nailing protects the soft-tissue envelope due to its minimally invasive approach and closed reduction techniques better than distal femoral locked plating. The purpose of this study was to evaluate and compare outcome of distal femur fracture stabilization using RN or LISS techniques. Materials and Methods: In a retrospective study from 2003 to 2008, we analyzed 115 patients with distal femur fracture who had been treated by retrograde IM nailing (59 patients or LISS plating (56 patients. In the two cohort groups, mean age was 54 years (17-89 years. Mechanism of injury was high energy impact in 57% (53% RN, 67% LISS and low-energy injury in 43% (47% RN, 33% LISS, respectively. Fractures were classified according to AO classification: there were 52 type A fractures (RN 31, LISS 21 and 63 type C fractures (RN 28, LISS 35; 32% (RN and 56% (LISS were open and 68% (RN and 44% (LISS were closed fractures, respectively. Functional and radiological outcome was assessed. Results: Clinical and radiographic evaluation demonstrated osseous healing within 6 months following RN and following LISS plating in over 90% of patients. However, no statistically significant differences were found for the parameters time to osseous healing, rate of nonunion, and postoperative complications. The following complications were treated: hematoma formation (one patient RN and three patients LISS, superficial infection (one patient RN and three patients LISS, deep infection (2 patients LISS. Additional secondary bone grafting for successful healing 3 months after the primary operation was required in four patients in the RN (7% of patients and six in the LISS group (10% of patients

Anomalies échocardiographiques chez l'hémodialysé chronique: prévalence et facteurs de risqué

OpenAIRE

Ezziani, Mariam; Najdi, Adil; Mikou, Souad; Elhassani, Anis; Akrichi, Mohammed Amine; Hanin, Hakim; Arrayhani, Mohammed; Houssaini, Tarik Sqalli

2014-01-01

Introduction Les complications cardio-vasculaires sont la principale cause de mortalité et de morbidité chez les patients hémodialysés chroniques. Le but de cette étude est de décrire les différentes atteintes cardiaques à l’échocardiographie transthoracique et de dégager les facteurs associés aux principales atteintes. Méthodes Etude transversale monocentrique incluant des patients adultes hémodialysés depuis plus d'un an et ayant bénéficié d'une échocardiographie transthoracique durant l'an...

Eddy current proximity measurement of perpendicular tubes from within pressure tubes in CANDU nuclear reactors

Science.gov (United States)

Bennett, P. F. D.; Underhill, P. R.; Morelli, J.; Krause, T. W.

2018-04-01

Fuel channels in CANDU® (CANada Deuterium Uranium) nuclear reactors consist of two non-concentric tubes; an inner pressure tube (PT) and a larger diameter calandria tube (CT). Up to 400 horizontally mounted fuel channels are contained within a calandria vessel, which also holds the heavy water moderator. Certain fuel channels pass perpendicularly over horizontally oriented tubes (nozzles) that are part of the reactor's liquid injection shutdown system (LISS). Due to sag, these fuel channels are at risk of coming into contact with the LISS nozzles. In the event of contact between the LISS nozzle and CT, flow-induced vibrations from within the moderator could lead to fretting and deformation of the CT. LISS nozzle proximity to CTs is currently measured optically from within the calandria vessel, but from outside the fuel channels. Measurement by an independent means would provide confidence in optical results and supplement cases where optical observations are not possible. Separation of PT and CT, known as gap, is monitored from within the PT using a transmit-receive eddy current probe. Investigation of the eddy current based gap probe as a tool to also measure proximity of LISS nozzles was carried out experimentally in this work. Eddy current response as a function of LISS-PT proximity was recorded. When PT-CT gap, PT wall thickness, PT resistivity and probe lift-off variations were not present this dependence could be used to determine the LISS-PT proximity. This method has the potential to provide LISS-CT proximity using existing gap measurement data. Obtaining LISS nozzle proximity at multiple inspection intervals could be used to provide an estimate of the time to LISS-CT contact, and thereby provide a means of optimizing maintenance schedules.

YOGA CLUB

CERN Document Server

Yoga Club

2010-01-01

NOUVELLES INSCRIPTIONS Liste des cours pour le semestre allant du 1er février au 30 juin 2010. Viniyoga (yoga progressif et adapté, appui sur la respiration) Professeur : Danielle Fahy 3 cours hebdomadaires   Lundi 11 h 15 – 12 h 30   12 h 30 – 13 h 45 (débutants) Mardi 12 h 15 – 13 h 30   Hatha Yoga et yoga chinois (tonification musculaire) Professeur : Marie-Claude Pihet 2 cours hebdomadaires   Mardi 17 h 30 – 18 h 30   18 h 30 – 19 h 30 (avancés)   Hatha Yoga et stretching Professeur : Michel Cohen 6 cours hebdomadaires   Mercredi 11 h 30 –...

Bien-être animal en élevage de poulets de chair

OpenAIRE

Arnould, Cécile; Leterrier, Christine

2007-01-01

L’élevage des poulets de chair s’est intensifié ces dernières décennies et de nombreux problèmes de bien-être animal sont apparus, en particulier chez les poulets standards et les reproducteurs à l’origine de ces croisements. Les poulets standards ont un niveau d’activité très faible et ils sont notamment atteints de troubles locomoteurs, de lésions cutanées et de pathologies cardio-vasculaires. Des solutions à ces altérations du bien-être peuvent être apportées en contrôlant des facteurs lié...

Qualite de vie apres un accident vasculaire cerebral au Senegal: a ...

African Journals Online (AJOL)

The accident was ischemic in 70% of cases, hemorrhagic in 30% of cases. 66% had a Barthel index between (60-100), 6% were between (0-20). The score was significantly better in young series (15-34), which all have a Barthel index between (60-100), more over 50% of patients in the portion above 75 years were in the ...

Flore vasculaire rare et endemique de la peninsule de l'Edough ...

African Journals Online (AJOL)

sous le nom de« biodiversity hotspots» [2]. La flore du bassin mediterraneen est aujourd'hui tres serieusement menacee, en raison de la forte regression des milieux naturels sous l' action de l 'homme, mais aussi parce que cette region serait l'une des plus exposees aux changements climatiques globaux [3-5]. Cette flore ...

Constructing elliptic curves from Galois representations

OpenAIRE

Snowden, Andrew; Tsimerman, Jacob

2017-01-01

Given a non-isotrivial elliptic curve over an arithmetic surface, one obtains a lisse $\\ell$-adic sheaf of rank two over the surface. This lisse sheaf has a number of straightforward properties: cyclotomic determinant, finite ramification, rational traces of Frobenius, and somewhere not potentially good reduction. We prove that any lisse sheaf of rank two possessing these properties comes from an elliptic curve.

Une Nouvelle Orientation Psychophysique dans la Pédagogie Théâtrale Contemporaine

Directory of Open Access Journals (Sweden)

Vezio Ruggieri

2015-09-01

Full Text Available Cet article a pour but de présenter comment les apports du modèle psychophysiologique bio-existentialiste élaboré par Vezio Ruggieri et ses collaborateurs peuvent jeter une lumière nouvelle sur les processus sous-jacents le jeu de l’acteur tels que la présence scénique, le processus d’identification avec un personnage et le complexe mécanisme de la prosodie. Cet encadrement théorique, qui voit le rapport corps-esprit dans une relation circulaire, éclairera le lecteur sur les bases physiologiques de la perception et de l’imagination ainsi que sur le rôle fondamental que la structure musculaire joue dans la construction de ces phénomènes.

Non disponible / Not available

OpenAIRE

Erika , Nnang Obada

2010-01-01

Non disponible / Not available; La préservation du capital vasculaire est un challenge permanent dans la prise en charge des patients insuffisants rénaux chroniques. Cette démarche doit être systématique, précoce, même en situation d'insuffisance rénale aiguë. La mise en place de cathéters pour l'hémodialyse doit être encadrée. Tout dysfonctionnement réduit l'efficacité d'une séance de dialyse avec une morbidité non négligeable. Dans une étude rétrospective de 62 patients hémodialysés inciden...

Réalité augmentée pour la chirurgie minimalement invasive du foie utilisant un modèle biomécanique guidé par l'image

OpenAIRE

Haouchine , Nazim; Cotin , Stéphane; Dequidt , Jérémie; Kerrien , Erwan; Berger , Marie-Odile

2014-01-01

National audience; Cet article présente une méthode de réalité augmentée pour la chirurgie minimalement invasive du foie. Le réseau vasculaire et les tumeurs internes reconstruites à partir des données pré-opératoires (IRM ou CT) peuvent ainsi être visualisées dans l'image laparoscopique afin de guider les gestes du chirurgien pendant l'opération. Cette méthode est capable de propager les déformations 3D de la surface du foie à ses structures internes grâce à un modèle biomécanique sous-jacen...

PRESSION PULSEE OU COUP DE BÉLIER HYDRAULIQUE. LE MIRACLE DE SAINT JANVIER : HYPOTHÈSE SUR L'ORIGINE DE L'HÉMORRAGIE CÉRÉBRALE DU SUJET HYPERTENDU.

OpenAIRE

Venet , Richard; Pavie , Alain; Léger , Philippe

2007-01-01

Un poète de l'entre deux guerres a décrit les circonstances de son accident vasculaire cérébral, nous évoquant « un coup de bélier hydraulique ». Pour Ahlqvist l'hémorragie cérébrale est secondaire à l'embolisation (occlusion instantanée) d'une artère cérébrale engendrant ainsi un coup de bélier responsable de la fissuration d'un micro-anévrisme de Charcot. Nous nous proposons dans cet article d'exposer le plus compendieusement possible la théorie du coup de bélier hydraulique. Appliquant cet...

HYPOTHÈSES SUR L'ORIGINE DES BRUITS DU CŒUR ET DES ACCIDENTS DE DÉCOMPRESSION EN PLONGÉE : LA CAVITATION. HYPOTHÈSE SUR L'ORIGINE DE LA FERMETURE DES VALVES CARDIAQUES : LE PHÉNOMÈNE DE VENTOUSE.

OpenAIRE

Venet , Richard ,; Pavie , Alain; Leger , Philippe

2012-01-01

Nous avons proposé, dans un travail antérieur, l'hypothèse d'un phénomène de cavitation à l'origine des bruits de Korotkoff. Encouragés par l'aphorisme de MacDonald comme quoi le phénomène de cavitation est plus fréquent qu'on peut le penser dans le système cardio-vasculaire, nous avons appliqué la théorie de Womersley aux enregistrements hémodynamiques exposés dans la littérature médicale. L'enregistrement simultané des pressions du ventricule gauche (PVG), de l'aorte (PAo) et de l'oreillett...

HYPOTHÈSES SUR L'ORIGINE DES BRUITS DU CŒUR ET DES ACCIDENTS DE DÉCOMPRESSION EN PLONGÉE : LA CAVITATION. HYPOTHÈSE SUR L'ORIGINE DE LA FERMETURE DES VALVES CARDIAQUES : LE RETARD A LA FERMETURE DES VALVES (COUP DE CLAPET) ET LE PHÉNOMÈNE DE VENTOUSE.

OpenAIRE

Venet , Richard ,

2012-01-01

Nous avons proposé, dans un travail antérieur, l'hypothèse d'un phénomène de cavitation à l'origine des bruits de Korotkoff. Encouragés par l'aphorisme de MacDonald comme quoi le phénomène de cavitation est plus fréquent qu'on peut le penser dans le système cardio-vasculaire, nous avons appliqué la théorie de Womersley aux enregistrements hémodynamiques exposés dans la littérature médicale. L'enregistrement simultané des pressions du ventricule gauche (PVG), de l'aorte (PAo) et de l'oreillett...

HYPOTHÈSES SUR L'ORIGINE DES BRUITS DU COEUR ET DES ACCIDENTS DE DÉCOMPRESSION EN PLONGÉE : LA CAVITATION

OpenAIRE

Venet , Richard

2007-01-01

Nous avons proposé, dans un travail antérieur, l'hypothèse d'un phénomène de cavitation à l'origine des bruits de Korotkoff. Encouragés par l'aphorisme de MacDonald comme quoi le phénomène de cavitation est plus fréquent qu'on peut le penser dans le système cardio-vasculaire, nous avons appliqué la théorie de Womersley aux enregistrements hémodynamiques exposés dans la littérature médicale. L'enregistrement simultané des pressions du ventricule gauche (PVG), de l'aorte (PAo) et de l'oreillett...

Sensibilisation aux gestes et postures de travail - French version only

CERN Multimedia

2004-01-01

Nous vous proposons un nouveau cours de sécurité lié aux manutentions manuelles (durée 1 jour) : Sensibilisation aux gestes et postures de travail. Si vous êtes amené à manipuler régulièrement des charges lourdes ou volumineuses, cette formation peut vous aider à prévenir les lésions musculaires ou dorsales. A l'issue de cette formation, vous serez capable d'adopter et d'appliquer les principes de base de sécurité physique et d'économie d'efforts dans les manipulations d'objets. Les cours sont pris en charge par la Commission de Sécurité. L'inscription EDH est obligatoire. Pour plus d'information, veuillez consulter les pages Formation & Développement (Groupe Sécurité)

Fréquence et caractéristiques des AVC impliquant les artères perforantes dans le Service de Neurologie de l’Hopital Bafelatanana, Antananarivo

Science.gov (United States)

Rasaholiarison, Nomena Finiavana; Randrianasolo, Rahamefy Odilon; Rajaonarison, Lala Andriamasinavalona; Rakotomanana, Jenny Larissa; Razafimahefa, Julien; Tehindrazanarivelo, Alain Djacoba

2017-01-01

Introduction Les accidents vasculaires cérébraux des artères perforantes sont surtout des artériolopathies. Ils évoluent vers la démence et la récurrence. Pour mieux prévenir ces complications notre étude avait pour but d'évaluer la fréquence et les caractéristiques de ces AVC. Méthodes c'est une étude descriptive rétrospective du 01 Mars au 25 Septembre 2015 au service de Neurologie CHU-JRB. Ont été inclus les patients présentant un déficit neurologique brutal et un scanner cérébral avec atteinte du territoire profonde. Les caractéristiques des AVC des artères perforantes ont été recueillies. Les données étaient traitées par le logiciel SPSS 20. Résultats Quatre-vingt-trois (48,25%) patients avaient des AVC des artères perforantes sur 172 AVC. Pour les AVC des artères perforantes la population était jeune avec 65,06% moins de 65 ans et à prédominance masculine avec 61,44%. Les formes hémorragiques étaient à 67,46%. Trente et un patients (37,34%) ont connu des récurrences et parmi eux presque le quart avait 2 récurrences avec 38,70% en moins de un an. Tous les patients avec récurrence avaient un trouble dysexécutif (p AVC pendant l'hospitalisation. Conclusion Un suivi spécifique en neurologie est nécessaire dès le premier accident vasculaire cérébral d'artère perforante pour dépister un début de démence et prévenir les récurrences. PMID:29255546

Experience in ultrasonic gap measurement between calandria tubes and liquid injection shutdown systems nozzles in Bruce Nuclear Generating Station

International Nuclear Information System (INIS)

Abucay, R.C.; Mahil, K.S.; Goszczynski, J.J.

1995-01-01

The gaps between calandria tubes (CT) and Liquid Injection Shutdown System (LISS) nozzles at the Bruce Nuclear Generating Station ''A'' (Bruce A) are known to decrease with time due to radiation induced creep/sag of the calandria tubes. If this gap decreases to a point where the calandria tubes come into contact with the LISS nozzle, the calandria tubes could fail as a result of fretting damage. Proximity measurements were needed to verify the analytical models and ensure that CT/LISS nozzle contact does not occur earlier than predicted. The technique used was originally developed at Ontario Hydro Technologies (formerly Ontario Hydro Research Division) in the late seventies and put into practical use by Research and Productivity Council (RPC) of New Brunswick, who carried out similar measurements at Point Lepreau NGS in 1989 and 1991. The gap measurement was accomplished y inserting an inspection probe, containing four ultrasonic transducers (2 to measure gaps and 2 to check for probe tilt) and a Fredericks electrolytic potentiometer as a probe rotational sensor, inside LISS Nozzle number-sign 7. The ultrasonic measurements were fed to a system computer that was programmed to convert the readings into fully compensated gaps, taking into account moderator heavy water temperature and probe tilt. Since the measured gaps were found to be generally larger than predicted, the time to CT/LISS nozzle contact is now being re-evaluated and the planned LISS nozzle replacement will likely be deferred, resulting in considerable savings

Comparison of micro column technology with conventional tube methods for antibody detection

Directory of Open Access Journals (Sweden)

Sachin Garg

2017-01-01

Conclusion: MCT was found to be most efficacious when compared to CTT and tube LISS-IAT in detecting clinically significant red cell antibodies; although MCT missed 2 cases of Lea antibody which were detected by CTT and LISS-IAT.

Safety Training: Sensibilisation aux gestes et postures de travail

CERN Multimedia

Laetitia Laddada

2004-01-01

Nous vous proposons un nouveau cours de sécurité lié aux manutentions manuelles (durée 1 jour) : Sensibilisation aux gestes et postures de travail. Si vous êtes amené à manipuler régulièrement des charges lourdes ou volumineuses, cette formation peut vous aider à prévenir les lésions musculaires ou dorsales. A l'issue de cette formation, vous serez capable d'adopter et d'appliquer les principes de base de sécurité physique et d'économie d'efforts dans les manipulations d'objets. Les cours sont pris en charge par la Commission de Sécurité. L'inscription EDH est obligatoire. Pour plus d'information, veuillez consulter les pages Formation & Développement (Groupe Sécurité). FORMATION EN SECURITE SAFETY TRAINING Laetitia Laddada 73811 - 79236 safety.training@cern.ch

La préservation du capital vasculaire au CHU Ibn Sina de Rabat ...

African Journals Online (AJOL)

Introduction: Tout patient ayant une maladie chronique nécessitant des prélèvements sanguins répétés ou des traitements par voie veineuse ou susceptible d'évoluer vers l'insuffisance rénale chronique, doit bénéficier d'une stratégie de préservation de son réseau veineux. Le but de ce travail était de déterminer le rôle de ...

Moya moya: étiologie rare d'accident vasculaire cérébral ...

African Journals Online (AJOL)

Moya moya disease is an angiogenic disease characterized by the narrowing of the distal internal carotid artery extending to the proximal segments of the middle and anterior cerebral arteries, inducing collateral vessels formation. These vessels come from the collateral parenchymal vessels, the perforating vessels, ...

Diversité floristique des épiphytes et hémiparasites vasculaires de l ...

African Journals Online (AJOL)

SARAH

30 sept. 2017 ... septembre sont en partie secs, entrainant une stabilité de l'air (Vennetier, 1977) ; (iii) une saison sèche et fraîche de juin à septembre, qui alterne avec une saison humide et chaude allant d'octobre à mai (Vennetier, 1977) ; (iv) l'humidité relative est particulièrement élevée, toujours supérieure à 70 %.

Incidence des accidents vasculaires cérébraux chez les patients VIH ...

African Journals Online (AJOL)

Introduction: avec l'introduction de la trithérapie dans les années 1996, la morbidité et la mortalité liées à l'infection par le VIH a nettement diminué. Concomitamment avec ce succès clinique, plusieurs changements métaboliques incluant diabète, hypertension artérielle, dyslipidémie et lipodystrophie ont été observés, ...

Estimation of spectral reflectance of snow from IRS-1D LISS-III ...

Indian Academy of Sciences (India)

R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

Marine and Water Resources Group, Space Applications Centre, Ahmedabad, 380 015, India. The sensor ... snowpack characteristics as a result of various metamorphic processes, with age, can cause varia- tions in its ... estimate the direct radiation income of slopes in ... model are: mean solar exo-atmospheric spectral.

YOGA CLUB

CERN Multimedia

Yoga club

2010-01-01

 NOUVELLES INSCRIPTIONS Liste des cours pour le semestre allant du 1 février au 30 juin 2010.  – Viniyoga (yoga progressif et adapté, appui sur la respiration) Professeur : Danielle Fahy 3 cours hebdomadaires : Lundi     11h15 – 12h30              12h30 – 13h45 (débutants) Mardi     12h15 – 13h30 – Hatha yoga et yoga chinois (tonification musculaire) Note : début de ce cours le 8 septembre 2009 Professeur : Marie-Claude Pihet 2 cours hebdomadaires : Mardi     17h30 – 18h30               18h30 – 19h30 (avancés) – Hath...

YOGA CLUB

CERN Document Server

CLUB DE YOGA

2010-01-01

DÉBUT DES COURS   mercredi 1er septembre 2010   (Yoga, Sophrologie, Tai Chi, Zen) Liste des cours pour le semestre allant du 1 er septembre 2010 au 31 janvier 2011. New: one course will be held in English Viniyoga (progressive and adaptable yoga, emphasis on breathing) Courses held in English Teacher: Marta Csatari 1 course per week Tuesday 12h15 – 13h30 Viniyoga (yoga progressif et adapté, appui sur la respiration) Professeur : Magali Roussel 2 cours hebdomadaires Lundi       11h15 – 12h30                12h30 – 13h45 (débutants) Hatha Yoga et yoga chinois (tonification musculaire) Professeur : Marie-Claude Pihet 2 cours hebdomadaires Mardi      17h30 – 18h30 &nb...

Safety Training: Sensibilisation aux gestes et postures de travail

CERN Multimedia

Laetitia Laddada

2004-01-01

Nous vous proposons un nouveau cours de sécurité lié aux manutentions manuelles (durée 1 jour) : Sensibilisation aux gestes et postures de travail. Si vous êtes amené à manipuler régulièrement des charges lourdes ou volumineuses, cette formation peut vous aider à prévenir les lésions musculaires ou dorsales. A l'issue de cette formation, vous serez capable d'adopter et d'appliquer les principes de base de sécurité physique et d'économie d'efforts dans les manipulations d'objets. Les cours sont pris en charge par la Commission de Sécurité. L'inscription EDH est obligatoire. Pour plus d'information, veuillez consulter les pages Formation & Développement (Groupe Sécurité). Formation & Développement (Groupe Sécurité) FORMATION EN SECURITE SAFETY TRAINING Laetitia Laddada 73811 - 79236 safety.training@cern.ch

Safety Training: Sensibilisation aux gestes et postures de travail

CERN Multimedia

Laetitia Laddada

2004-01-01

Nous vous proposons un nouveau cours de sécurité lié aux manutentions manuelles (durée 1 jour) : Sensibilisation aux gestes et postures de travail. Si vous êtes amené à manipuler régulièrement des charges lourdes ou volumineuses, cette formation peut vous aider à prévenir les lésions musculaires ou dorsales. A l'issue de cette formation, vous serez capable d'adopter et d'appliquer les principes de base de sécurité physique et d'économie d'efforts dans les manipulations d'objets. Les cours sont pris en charge par la Commission de Sécurité. L'inscription EDH est obligatoire. Pour plus d'information, veuillez consulter les pages Formation & Développement (Groupe Sécurité). Formation & Développement (Groupe Sécurité) FORMATION EN SECURITE SAFETY TRAINING Laetitia Laddada 73811 - 79236 sa...

Safety Training: Sensibilisation aux gestes et postures de travail

CERN Multimedia

Laetitia Laddada

2004-01-01

>Nous vous proposons un nouveau cours de sécurité lié aux manutentions manuelles (durée 1 jour) : Sensibilisation aux gestes et postures de travail. Si vous êtes amené à manipuler régulièrement des charges lourdes ou volumineuses, cette formation peut vous aider à prévenir les lésions musculaires ou dorsales. A l'issue de cette formation, vous serez capable d'adopter et d'appliquer les principes de base de sécurité physique et d'économie d'efforts dans les manipulations d'objets. Les cours sont pris en charge par la Commission de Sécurité. L'inscription EDH est obligatoire. Pour plus d'information, veuillez consulter les pages Formation & Développement (Groupe Sécurité). Formation & Développement (Groupe Sécurité) FORMATION EN SECURITE SAFETY TRAINING Laetitia Laddada 73811 - 79236 s...

Yoga Club

CERN Multimedia

Yoga Club

2011-01-01

YOGA CLUB – REPRISE DES COURS (Yoga, Sophrologie, Tai Chi, Zen) Liste des cours pour le semestre allant du 5 septembre 2011 au 31 janvier 2012. YOGA d'inspiration Viniyoga et Thibétaine Professeur : Danielle Fahy 3 cours hebdomadaires Lundi  11h15 – 12h30           12h30 – 13h45 (débutants) Mardi  12h15 – 13h30 Viniyoga (progressive and adaptable yoga, emphasis on breathing) Courses held in English Teacher: Beatriz Recio Palomero 1 course per week Tuesday  12h15 – 13h30 Hatha Yoga et yoga chinois (tonification musculaire) Professeur : Marie-Claude Pihet 2 cours hebdomadaires Mardi  17h30 – 18h30           18h30 – 19h30 (avancés) Hatha Yoga et stretching Professeur : Michel Cohen 6 cours h...

Safety Training: Sensibilisation aux gestes et postures de travail

CERN Multimedia

Laetitia Laddada

2004-01-01

If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt.Nous vous proposons un nouveau cours de sécurité lié aux manutentions manuelles (durée 1 jour) : Sensibilisation aux gestes et postures de travail. Si vous êtes amené à manipuler régulièrement des charges lourdes ou volumineuses, cette formation peut vous aider à prévenir les lésions musculaires ou dorsales. A l'issue de cette formation, vous serez capable d'adopter et d'appliquer les principes de base de sécurité physique et d'&e...

Safety Training: Sensibilisation aux gestes et postures de travail

CERN Multimedia

Laetitia Laddada

2004-01-01

If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. Nous vous proposons un nouveau cours de sécurité lié aux manutentions manuelles (durée 1 jour) : Sensibilisation aux gestes et postures de travail. Si vous êtes amené à manipuler régulièrement des charges lourdes ou volumineuses, cette formation peut vous aider à prévenir les lésions musculaires ou dorsales. A l'issue de cette formation, vous serez capable d'adopter et d'appliquer les principes de base de sécurité physique et d'économie d'efforts dans les manipulations...

Yoga Club

CERN Document Server

Yoga Club

2011-01-01

DÉBUT DES COURS mardi 1er février 2011 (Yoga, Sophrologie, Tai Chi, Zen) Liste des cours pour le semestre allant du 1 er février 2011 au 30 juin 2011.   Viniyoga (progressive and adaptable yoga, emphasis on breathing)  Courses held in English Teacher : Marta Csatari 1 course per week Tuesday 12h15 – 13h30 Yoga d’inspiration Viniyoga et Thibétaine Professeur : Danielle FAHY 2 cours hebdomadaires Lundi 11h15 – 12h30          12h30 – 13h45 Hatha Yoga et yoga chinois (tonification musculaire) Professeur : Marie-Claude Pihet 2 cours hebdomadaires Mardi 17h30 – 18h30            18h30 – 19h30 (avancés) Hatha Yoga et stretching Professeur : Michel Cohen 6 cours hebdomadaires Mercredi 11h30 &...

Yoga Club

CERN Multimedia

Yoga Club

2011-01-01

DÉBUT DES COURS mardi 1er février 2011 (Yoga, Sophrologie, Tai Chi, Zen)   Liste des cours pour le semestre allant du 1 er février 2011 au 30 juin 2011.   Viniyoga (progressive and adaptable yoga, emphasis on breathing)  Courses held in English Teacher : Marta Csatari 1 course per week Tuesday 12h15 – 13h30 Yoga d’inspiration Viniyoga et Thibétaine Professeur : Danielle FAHY 2 cours hebdomadaires Lundi 11h15 – 12h30           12h30 – 13h45 Hatha Yoga et yoga chinois (tonification musculaire) Professeur : Marie-Claude Pihet 2 cours hebdomadaires Mardi 17h30 – 18h30            18h30 – 19h30 (avancés) Hatha Yoga et stretching Professeur : Michel Cohen 6 cours hebdomadai...

(Ananas comosus (L.) Merrill) cultivées au Bénin

African Journals Online (AJOL)

SARAH

31 mars 2015 ... morphotypes ont été identifiés et dénombrés à l'intérieur de 5 placeaux de 4 m2 dans chaque plantation. Les variétés d'ananas recensées sont au nombre de 5, à savoir : Cayenne lisse, Pain de sucre, Queen, Red. Spanish et Perolera. Elles renferment 16 morphotypes dont 4 pour la Cayenne lisse, ...

2540-IJBCS-Article-Kadidia Semde

African Journals Online (AJOL)

hp

avec une écorce grise, assez lisse et un tronc lisse (Figure 2b). MaLs est arbustif de 7 m de hauteur avec un dhp de 25 cm, l'écorce est écailleuse, grise et un tronc non droit. Il est porté par un tronc principal de Lannea microcarpa dont la ramification commence à partir du tronc principal à une cinquantaine de centimètre du ...

Le poin: Mondialisation, Agro-industries, Globalisation des Modes alimentaires et Nouveaux Enjeux Sanitaires : L’Agriculture Biologique, peut-elle être, une solution du problème [Globalization, Agri-industries, food globalization and sanitary new challenges : Organic agriculture, can it be a solution

Directory of Open Access Journals (Sweden)

Hassini TSAKI

2016-06-01

Full Text Available Les nutritionnistes, épidémiologistes, chercheurs de biologie, médecins, agrobiologistes et autres compétences de vocations connexes demeurent, aujourd’hui et pour une plus juste définition et diagnostic de ces phénomènes liés à la nutrition et santé publique, dans la nécessité pour une meilleure approche d’intégration des informations, de privilégier l’établissement d’une synthèse collégiale sur les différents aspects d’incidences de nos nouveaux modes alimentaires en relation avec les nombreuses et nouvelles maladies chroniques en développement dans nos sociétés modernes (obésité, maladies cardio-vasculaires, diabète, hypertension artérielle, cancers, etc.….

Discrete symmetries: A broken look at QCD

International Nuclear Information System (INIS)

Goldman, T.

1996-01-01

The alphabet soup of discrete symmetries is briefly surveyed with a view towards those which can be tested at LISS and two particularly interesting cases are called out. A LISS experiment may be able to distinguish CP violation that is not due to the QCD θ term. The elements of a model of parity violation in proton-nucleon scattering, which is consistent with lower energy LAMPF and ANL results, are reviewed in the light of new information on diquarks and the proton spin fraction carried by quarks. The prediction that the parity violating total cross section asymmetry should be large at LISS energies is confirmed. The results of such an experiment can be used both to obtain new information about the diquark substructure of the nucleon and to provide bounds on new right-chiral weak interactions

Images in medicine

African Journals Online (AJOL)

abp

1 oct. 2015 ... maxillaires et un larmoiement. L'inspection a montré une hémiface fortement déformée par une tuméfaction lisse faisant huit centimètres de grand axe (A,B), de consistance dure à la palpation. La rhinoscopie antérieure a révélé dans la cavité nasale gauche une tumeur lisse, blanchâtre, non hémorragique ...

A search for PAHs in the ISO spectra of comet Hale-Bopp

Science.gov (United States)

Crovisier, J.; Bockelée-Morvan, D.

2007-12-01

From a new analysis of a spectrum of comet C/1995 O1 (Hale-Bopp) obtained with the Infrared Space Observatory (ISO), Lisse et al. (2007) claimed the identification of many new dust species. Among them are PAHs, which were not found in our first analysis of the ISO spectra. We present a re-examination of the ISO observations of comet Hale-Bopp, which does not confirm the conclusion of Lisse et al.

An analysis on water hammer in liquid injection shutdown system of CANDU-9

International Nuclear Information System (INIS)

Kim, T. H.; Heo, J.; Han, S. K.; Choi, H. Y.; No, T. S.

2000-01-01

The water hammer analysis code, PTRAN, is used for computation of transient pressures and pressure differentials in the Liquid Injection Shutdown System(LISS) piping network of CANDU-9 to ensure that the design allowables for LEVEL C Service Limit are met for the water hammer loads resulting from the water hammer. The LISS piping network of CANDU-9 has incorporated design improvement in considering the water hammer, such as declining the horizontal part of helium header, and raising the elevation of the overall system piping configuration, etc. The maximum pressure in the LISS piping network is found to be 7.92 MPa(a) at the closed valve in the vent line, which is below the allowable working pressure and the valve design pressure under Level C service conditions. And it is also shown that the maximum pressure in CANDU-9 is much lower than that in CANDU-6

Immuunstromale corneale ulceratie na een oogoperatie bij patiënten met collageen-vasculaire auto-immuunaandoeningen

NARCIS (Netherlands)

van der Meulen, I. J. E.; van Rooij, J.; Hazes, J. W. M.; van Cleynenbreugel, H.; Geerards, A. J. M.; Remeyer, L.

2007-01-01

Two women aged 78 and 74 years respectively, both with dry eyes due to underlying auto-immune disorders, presented after uncomplicated cataract surgery with immunostromal corneal ulceration. Intensive topical lubrication combined with systemic immunosuppressants were necessary to control the corneal

Restoration scaling of seagrass habitats in the oceanic islands of Lakshadweep, India using geospatial technology

Digital Repository Service at National Institute of Oceanography (India)

Nobi, E.P.; Dilipan, E.; Thangaradjou, T.; DineshKumar, P.K.

) Guidelines for the conservation and restoration of seagrasses in the United States and adjacent waters. Silver Spring (MD): NOAA Coastal Ocean Program Decision Analysis Series no. 12 Harrison PG (1990) Variations in success of eelgrass transplants over a... and field observations Satellite data of the years 2000 (IRS ID LISS III) and 2008 (IRS P6 LISS III) were used for estimating the seagrass spatial changes over a time period for the six islands following the methodology of Mumby and Green (2000). Digital...

Large solar heating system with seasonal storage for buld drying in Lisse, the Netherlands

NARCIS (Netherlands)

Bokhoven, T.P.; Geus, A.C. de

1996-01-01

Within IEA Task 14 (Advanced Solar Systems) of the IEA Solar Heating and Cooling Programme a working group was established dealing with large advanced solar energy systems (the Large Systems Working group). The goal of this working group was to generate a common base of experiences for the design

Advances in the physics modelling of CANDU liquid injection shutdown systems

International Nuclear Information System (INIS)

Smith, H.J.; Robinson, R.; Guertin, C.

1993-01-01

The physics modelling of liquid poison injection shutdown systems in CANDU reactors accounts for the major phenomena taking place by combining the effects of both moderator hydraulics and neutronics. This paper describes the advances in the physics modelling of liquid poison injection shutdown systems (LISS), discusses some of the effects of the more realistic modelling, and briefly describes the automation methodology. Modifications to the LISS methodology have improved the realism of the physics modelling, showing that the previous methodology significantly overestimated energy deposition during the simulation of a loss of coolant transient in Bruce A, by overestimating the reactivity transient. Furthermore, the automation of the modelling process has reduced the time needed to carry put LISS evaluations to the same level as required for shutoff-rod evaluations, while at the same time minimizing the amount of input, and providing a method for tracing all files used, thus adding a level of quality assurance to the calculation. 5 refs., 11 figs

Osteosynthesis of a periprosthetic fracture of the proximal femur with the distal femur LISS system

DEFF Research Database (Denmark)

Tarnowski, Jan Robert; Holck, Kim

2008-01-01

In this case report, we show how it is possible to perform osteosynthesis using minimal invasive techniques instead of conventional methods. In this instance the osteosynthesis was performed on a patient in poor general condition who had presented a periprosthetic fracture of the proximal femur. ...

Myélome multiple survenant au cours d'une Fièvre Méditerranéenne Familiale

Science.gov (United States)

Salem, Bouomrani; Afef, Farah; Nadia, Bouassida; Nabil, Ayadi; Zouhir, Bahloul; Maher, Béji

2013-01-01

L'objectif de ce travail est de rapporter une observation particulière de myélome multiple survenant au cours d'une maladie périodique. Il s'agit d'un patient tunisien de 53 ans suivi depuis le jeune âge pour maladie périodique dont le diagnostic était confirmé par l’étude génétique montrant l'homozygotie pour la mutation M694V du gène MEFV, fut admis pour exploration d'une douleur avec tuméfaction fessière droite récente. Les explorations biologiques et radiologiques ont permis de retenir le diagnostic d'un myélome multiple de type IgA à chaînes légères kappa stade III B, associé à une volumineuse localisation plasmocytaire très agressive de l'aile iliaque droite envahissant les structures musculaires avoisinantes. Notre observation, qui à notre connaissance est la deuxième signalant une telle association, se distingue par sa survenue brutale, sa progression rapide et le caractère très agressif de l'hémopathie. PMID:24255729

RESOURCESAT-2: a mission for Earth resources management

Science.gov (United States)

Venkata Rao, M.; Gupta, J. P.; Rattan, Ram; Thyagarajan, K.

2006-12-01

The Indian Space Research Organisation (ISRO) has established an operational Remote sensing satellite system by launching its first satellite, IRS-1A in 1988, followed by a series of IRS spacecraft. The IRS-1C/1D satellites with their unique combination of Payloads have taken a lead position in the Global remote sensing scenario. Realising the growing User demands for the "Multi" level approach in terms of Spatial, Spectral, Temporal and Radiometric resolutions, ISRO identified the Resourcesat as a continuity as well as improved RS Satellite. The Resourcesat-1 (IRS-P6) was launched in October 2003 using PSLV launch vehicle and it is in operational service. Resourcesat-2 is its follow-on Mission scheduled for launch in 2008. Each Resourcesat satellite carries three Electro-optical cameras as its payload - LISS-3, LISS-4 and AWIFS. All the three are multi-spectral push-broom scanners with linear array CCDs as Detectors. LISS-3 and AWIFS operate in four identical spectral bands in the VIS-NIR-SWIR range while LISS-4 is a high resolution camera with three spectral bands in VIS-NIR range. In order to meet the stringent requirements of band-to-band registration and platform stability, several improvements have been incorporated in the mainframe Bus configuration like wide field Star trackers, precision Gyroscopes, on-board GPS receiver etc,. The Resourcesat data finds its application in several areas like agricultural crop discrimination and monitoring, crop acreage/yield estimation, precision farming, water resources, forest mapping, Rural infrastructure development, disaster management etc,. to name a few. A brief description of the Payload cameras, spacecraft bus elements and operational modes and few applications are presented.

Observational Trends of Cometary X-ray Emission

Science.gov (United States)

Lisse, C. M.

2001-05-01

The unexpected discovery of x-ray emission from Comet Hyakutake in March 1996 (Lisse et al. 1996) has produced a number of questions about the physical mechanism producing the radiation. The original detection and subsequent observations (Dennerl et al. 1997, Mumma et al. 1997, Krasnopolsky et al. 1998, Owens et al. 1998, Lisse et al. 1999, Lisse et a. 2001, Dennerl et al. 2001) have shown that the very soft (best fit thermal bremsstrahlung model kT = 0.23 keV) emission is due to an interaction between the solar wind and the comet's atmosphere. Using the results from the more than 15 comets detected to date in x-rays, we report on the latest results on cometary x-ray emission. Our emphasis will be on understanding the physical mechanism producing the emission, and using this to determine the nature of the cometary coma and solar wind flux. As-observed morphologies, spectra, and light curves will be discussed. We also report on the status of current cometary observations using the new powerful x-ray observatories Chandra and XMM. This work has been graciously supported by grants from the NASA Planetary Astronomy and Astrophysical Data Programs.

Composition en acide alphalinolénique des esters de cholestérol plasmatiques : un marqueur de consommation chez l’homme

Directory of Open Access Journals (Sweden)

Combe Nicole

2002-07-01

Full Text Available Le lien existant entre qualité et quantité des acides gras de l’alimentation, et santé est de plus en plus évident et défini, comme l’indique la revue des travaux plus spécifiquement consacrés aux implications dans le risque de maladies cardiovasculaires (MCV (cf. premier exposé de ce dossier. Néanmoins, si un grand nombre d’études épidémiologiques ou d’intervention ont permis d’aboutir à un consensus qui s’est traduit, en France, par la publication en 2001 des Apports Nutritionnels Conseillés [1], un débat perdure au sein de la communauté scientifique internationale sur les meilleurs apports en acides gras monoinsaturés versus poly-insaturés [2, 3]. Les études récentes de Rudel et al. [4-6] indiquent en effet que des singes nourris avec un régime très enrichi en acide oléique (18:1n-9 : 24% de l’apport énergétique développent une athérosclérose des artères coronaires qui pourrait être en relation avec l’accumulation subséquente d’oléate de cholestérol dans les LDL aux dépens du linoléate de cholestérol. Par ailleurs, eu égard aux effets bénéfiques reconnus à l’acide alphalinolénique (18:3n-3 vis-à-vis des risques d’infarctus du myocarde, de cardiopathie ischémique [7-9] et d’accident vasculaire cérébral [10, 11], le niveau de 18:3n-3 dans les esters de cholestérol (EC du plasma apparaît comme un bon indicateur de protection. En effet, l’étude conduite par Sandker et al. [12], sur deux groupes d’hommes âgés, issus des cohortes crétoises (Seven Countries Study et hollandaises (Zutphen Study, a permis de faire émerger l’intérêt de ce marqueur biologique. En moyenne, le pourcentage de 18:3n-3 mesuré dans les EC plasmatiques des Crétois était significativement plus élevé comparé à celui des Hollandais (0,9% vs 0,32% des acides gras, dont la cohorte présentait un taux de mortalité coronarienne 5 fois plus grand que celui de la cohorte crétoise. En outre, l�

Etiologies des pleurésies exsudatives: à propos de 424 cas à Madagascar

Science.gov (United States)

Rakotoson, Joëlson Lovaniaina; Andrianasolo, Radonirina Lazasoa; Rakotomizao, Robert Jocelyn; Vololontiana, Marie Danielle Hanta; Ravahatra, Kiady; Rajaoarifetra, Jobeline; Andrianarisoa, Christophe Félix Ange

2011-01-01

Introduction La pleurésie constitue un motif fréquent de consultation en pneumologie. Notre travail a pour objectif de déterminer les étiologies des pleurésies exsudatives afin d'en faciliter les démarches étiologiques. Méthodes Il s'agit d'une étude rétrospective réalisée chez des patients ayant une pleurésie exsudative et bénéficiant une biopsie pleurale à l'aveugle à l'aide de l'aiguille de Castelain, pendant une période de 5 ans (2005 à 2009). Résultats Parmi les 424 patients inclus, 259 hommes (61,08%) et 165 femmes (38,91%) étaient individualisés. Les pleurésies étaient d'origine tuberculeuse dans 298 cas (70, 28%), métastatique dans 63 cas (14,85%), inflammation non spécifique dans 51 cas (12,02%). Des fibres musculaires striées étaient biopsiées dans 12 cas (2,83%). Conclusion La biopsie pleurale occupe une place prépondérante dans la recherche étiologique des pleurésies d'exsudatives à Madagascar où la tuberculose sévit encore en mode endémique. PMID:22145067

Evaluation du risque d’accident vasculaire cérébral à l’aide de la logique floue.

OpenAIRE

BENCHERIF, Farah Nezha

2015-01-01

Ce projet s’inscrit dans le cadre d’une stratégie de prévention-santé publique par le suivi et l’évaluation du risque, une approche d’intelligence artificielle basée sur la logique floue a été mise en œuvre ,dans ce cadre une application informatique d’aide au diagnostique baptisée « eRisk » : « evaluation of eRisk » a été réalisée et évaluée à partir de données préexistantes ainsi que l’avis expert du médecin , les résultats encourageants ainsi obtenus sont une ébauche vers la...

Migration and reproductive behavior in Turkish migrant families

OpenAIRE

Nauck, Bernhard

1987-01-01

Migration and reproductive behavior in Turkish migrant families : a situational explanation. - In: Growth and progress in cross-cultural psychology / ed. by Cigdem Kagitcibasi. - Lisse u.a. : Swets & Zeitlinger, 1987. - S. 336- 345

Comets As Objects of High Energy Astrophysics

Science.gov (United States)

Ibadov, S.

2000-10-01

Strong soft X-ray emission from comet Hyakutake C/1996 B2 was discovered with ROSAT in March 27, 1996 (Lisse et al. 1996, Science 274, 205-209) and the results of a theoretical approach (Ibadov 1990, Icarus 86, 283-288) served as a motive for that observations (Dennerl, Lisse and Truemper 1998, Private Communications). It is now well established that comets emit EUV and X-rays regularly (Dennerl, Englhauser and Truemper 1997, Science 277, 1625-1630; Dennerl 1998, Proc. 16th Int. Conf. Atomic Physics, Windsor, Ontario, Canada). To explain this phenomenon different theoretical models were proposed (Krasnopolsky 1997, Icarus 128, 365-385; Ibadov 1998, Proc. First XMM Workshop, Noordwijk, The Netherlands, and references therein). In the paper the problem of identifying X-ray generation mechanisms in comets will be considered.

Electrophoretic protein polymorphisms in Kaingang and Guarani Indians of Southern Brazil.

Science.gov (United States)

Salzano, Francisco M; Callegari-Jacques, Sidia M; Weimer, Tania A; Franco, Maria H L P; Hutz, Mara H; Petzl-Erler, Maria L

1997-01-01

A total of 337 Kaingang and Guarani Indians from two localities were studied in relation to 18 protein genetic loci. In one of the localities, members of these two groups live side by side but show little genetic similarity, emphasizing the influence of cultural factors in the mating behavior of human groups. Integrating the present results with previous ones, it was verified that the genetic relationships among six Kaingang populations do not follow the pattern expected from their geographical distribution. Comparisons made with three other Ge˜-speaking tribes indicate that the Kaingang did not separate well from them. Most (96%) of the variability in the six polymorphic systems considered occur at the intrapopulational level. Am. J. Hum. Biol. 9:505-512, 1997. © 1997 Wiley-Liss, Inc. Copyright © 1997 Wiley-Liss, Inc.

Mise au point

African Journals Online (AJOL)

Laryngeal leiomyosarcoma is extremely rare malignant tumor that arises from smooth muscle cells. It constitutes less than ... muscles lisses sont abondants, à savoir l'utérus, le trac- ... Head and neck sarcoma: prognostic factors and.

NJP VOLUME 41 NO 4

African Journals Online (AJOL)

PROF. EZECHUKWU

2014-05-03

a85584.pdf (Accessed. 12/12/2013). 13. Hudelson P. Gender differentials in tuberculosis: the role of socio- economic and cultural factors. Tubercle and Lung Disease. 1996;77:391e400. 14. Gustafson P, Lisse I, Gomes V,.

Path analysis of risk factors leading to premature birth.

Science.gov (United States)

Fields, S J; Livshits, G; Sirotta, L; Merlob, P

1996-01-01

The present study tested whether various sociodemographic, anthropometric, behavioral, and medical/physiological factors act in a direct or indirect manner on the risk of prematurity using path analysis on a sample of Israeli births. The path model shows that medical complications, primarily toxemia, chorioammionitis, and a previous low birth weight delivery directly and significantly act on the risk of prematurity as do low maternal pregnancy weight gain and ethnicity. Other medical complications, including chronic hypertension, preclampsia, and placental abruption, although significantly correlated with prematurity, act indirectly on prematurity through toxemia. The model further shows that the commonly accepted sociodemographic, anthropometric, and behavioral risk factors act by modifying the development of medical complications that lead to prematurity as opposed to having a direct effect on premature delivery. © 1996 Wiley-Liss, Inc. Copyright © 1996 Wiley-Liss, Inc.

Comparative myology of the unicornfishes, Naso (Acanthuridae, Percomorpha), with implications for phylogenetic analysis.

Science.gov (United States)

Borden, W Calvin

1999-02-01

Striated muscles of 15 species of unicornfishes (Naso, Acanthuridae) are described in detail. Of 93 muscles dissected, only five demonstrate intrageneric variation, providing only ten characters suitable for phylogenetic analysis. Thus, myology appears to be highly conservative at the species level and has been so for approximately 50-55 million years in this particular group of fishes. Furthermore, myology is static relative to osteology in Naso and at any taxonomic rank within fishes, implying osteology provides a larger but not necessarily more valuable data source for systematic studies. Although important for their epistomological value, these descriptions provide a basis for further studies ranging from functional, comparative, and systematic analyses, ultimately with the potential to address questions of historical ecology (i.e., speciation, adaptation, coevolution) within Naso. J. Morphol. 239:191-224, 1999. © 1999 Wiley-Liss, Inc. Copyright © 1999 Wiley-Liss, Inc.

Anatomy and histochemistry of spread-wing posture in birds. I. Wing drying posture in the double-crested cormorant, Phalacrocorax auritus.

Science.gov (United States)

Meyers, Ron A

1997-07-01

Spread-wing postures of birds often have been studied with respect to the function of behavior, but ignored with regard to the mechanism by which the birds accomplish posture. The double-crested cormorant, Phalacrocorax auritus, was used as a model for this study of spread-wing posture. Those muscles capable of positioning and maintaining the wing in extension and protraction were assayed histochemically for the presence of slow (postural) muscle fibers. Within the forelimb of Phalacrocorax, Mm. coracobrachialis cranialis, pectoralis thoracicus (cranial portion), deltoideus minor, triceps scapularis, and extensor metacarpi radialis pars dorsalis and ventralis were found to contain populations of slow-twitch or slow-tonic muscle fibers. These slow fibers in the above muscles are considered to function during spread-wing posture in this species. J Morphol 233:67-76, 1997. © 1997 Wiley-Liss, Inc. Copyright © 1997 Wiley-Liss, Inc.

A NEW FRESHWATER GOBY (TELEOSTEI: GOBIIDAE) FROM THE ...

African Journals Online (AJOL)

497. JUDB, R. A. 1967. Freshwater fishes of southern Africa. Cape Town: Balkema. KOUMANS, F. P. 1931. A preliminary revision of the genera of the gobioidfishes with united ventral fins. N. V. Lisse. (Netherlands) 1-174: Drukkerij, Imperator. R.

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

High resolution remote sensing data (IKONOS and IRS LISS-IV) were used to ... be lowest in very dense forest and highest in the open forest in the hilly landform. ... Forestry and Ecology Department, Indian Institute of Remote Sensing, ISRO, ...

The Time Analysis and Frequency Distribution of Caesium-137 Fall-Out in Muscle Samples; Analyse en Fonction du Temps et Distribution des Frequences de Cesium 137 du aux Retombees de Cesium 137 Contenues dans des Echantillons de Tissu Musculaire; 0410 041d 0414 ; Analisis Temporal y Distribucion de Frecuencias del Cesio-137 Procedente de la Precipitacion Radiactiva en Muestras de Tejido Muscular

Energy Technology Data Exchange (ETDEWEB)

Ellett, W. H.; Brownell, G. L [Physics Research Laboratory, Massachusetts General Hospital, Boston 14, MA (United States)

1964-11-15

activity for any level of fall-out. We have tested this model for the fourfold increase in activity since mid-1962 and have found it to predict accurately the present distribution of caesium-137 radioactivity between individual members of the sample population. (author) [French] Les faibles concentrations de radioactivite artificielle dans l'organisme risquent d'avoir des effets nuisibles dans une population surtout pour les individus chez qui cette concentration atteint une valeur plusieurs fois superieure a la moyenne. On ne peut estimer valablement les dangers dus aux retombees radioactives que si l'on connait la loi de frequence de la radioactivite dans la population. Les tentatives faites pour determiner la forme de la courbe de frequence a partir des donnees de Kulp sur la concentration du strontium 90 dans les tissus osseux d'enfants n'ont abouti qu'a des resultats limites en laison de la petite taille de'l'echantillon et de l'absence d'equilibre entre le strontium 90 et le calcium dans ces tissus. Pour y remedier, les auteurs ont dose le cesium 137 d'environ 900 echantillons de tissus musculaires. Ces echantillons avaient ete preleves a l'occasion d'autopsies pratiquees entre janvier 1959 et aout 1963. En utilisant le cesium 137 comme indicateur des produits de fission, on s'assure que tous les individus du'groupe, quel que fut leur age, etaient essentiellement en equilibre avec la radioactivite ambiante au moment de leur deces. L'enquete a ete faite pendant la periode correspondant a la premiere interruption des essais d'engins nucleaires et a la reprise en grand de ces essais a l'automne 1961. La teneur moyenne en cesium 137 des echantillons de tissus musculaires est restee relativement constante durant toute l'annee 1959, puis a diminue d'un facteur de deux en 1960 et est demeuree relativement stable jusqu'au debut de l'ete 1962. A partir de juillet 1962, le niveau moyen de la radioactivite due au cesium 137 dans la population d'echantillons a continuellement

Tumeur d'Abrikossoff juxta axillaire: une localisation rare d'une tumeur très rare, à propos d'un cas

Science.gov (United States)

Amourak, Sarah; Bouzoubaa, Wael; Jayi, Sofia; Alaoui, Fatimazahra Fdili; Chaara, Hikmat; Melhouf, Moulay Abdelilah

2015-01-01

Décrite pour la première fois en 1926 par Abrikossoff, les tumeurs à cellules granuleuses (TCG) sont bénignes et uniques dans la grande majorité des cas. Les principales localisations sont la cavité orale, puis les tissus sous-cutanés de la tête et du cou et les seins. La pathogenèse a été longtemps débattue, après avoir proposé initialement une origine musculaire striée les études récentes sont en faveur d'une origine neurogène schwannienne confirmées par une étude immunohistochimique. Le traitement de la tumeur à cellules granuleuses est un traitement chirurgical, il permet un diagnostic de certitude par l'examen anatomo-pathologique de la pièce d'exérèse qui doit rechercher les limites d'exérèse et la présence de critères de malignité. Leur évolution est souvent favorable si la résection chirurgicale est complète. Nous rapportons ici le cas d'une tumeur d'Abrikossoff à localisation juxta axillaire et nous profitons de faire une revue de la littérature afin de mettre le point sur cette entité rare. PMID:26328001

Magnetron with smooth anode. Statistical theory and ordered oscillations; Magnetron a anode lisse. Theorie statistique et oscillations ordonnees

Energy Technology Data Exchange (ETDEWEB)

Coste, J.

1961-03-15

We have to investigate the equilibrium regime that appears between a hot cathode and the electronic cloud that is confined around the cathode by a magnetic field parallel to its axis. The densities being high enough to involve the effect of space charge. The challenge of the magnetron theory is to face 2 issues: first the structure of the electronic cloud in a diode submitted to a magnetic field and secondly the oscillations that are likely to appear in this cloud. In this work we have made 2 attempts to clarify the situation, we have extended the classical theory of the static charge of space through a study of its oscillation modes on one hand and on the other hand we have tackled the issue of the structure of the electronic cloud with the tool of statistics. This document is divided into 2 chapters. In the first chapter we present a static study of the magnetron in which we take a statistical approach deliberately. We give answers to the issue of the thermodynamical equilibrium of the electronic cloud and we have found a mode very close to the Brillouin mode. The statistical approach has made us discuss the boundary conditions on the cathode, it means the coupling between the cathode and the electronic cloud. In the second chapter we present the theoretical study of the oscillations in a magnetron operating in the Brillouin mode. The resonances that appear in experimental data stay difficult to explain.

Effects of religion, economics, and geography on genetic structure of Fogo Island, Newfoundland.

Science.gov (United States)

Crawford, M H; Koertevlyessy, T; Huntsman, R G; Collins, M; Duggirala, R; Martin, L; Keeping, D

1995-01-01

The population structure of Fogo Island, Newfoundland is described using geography, religious affiliation, economic factors (such as the presence of a fish-packing plant), and genetic markers. Five different analytic methods, R-matrix analysis, r ii VS. mean per locus heterozygosity, predicted kinship (ϕ), mean first passage time, and Mantel matrix comparisons, were applied to the Fogo Island genetic and demographic data. The results suggest that geography plays a role on Fogo Island in the distribution of genes, while religion, ethnicity, and economic factors play less significant roles. The communities with fish-packing plants and tourism serve as migratory "sinks" for Fogo islanders seeking employment. Reproductively, the most isolated village on Fogo Island is Tilting, and this is reflected in its genetic uniqueness, initially caused by Irish settlement and subsequently the action of stochastic processes. © 1995 Wiley-Liss, Inc. Copyright © 1995 Wiley-Liss, Inc., A Wiley Company.

An advanced simulator for orthopedic surgical training.

Science.gov (United States)

Cecil, J; Gupta, Avinash; Pirela-Cruz, Miguel

2018-02-01

The purpose of creating the virtual reality (VR) simulator is to facilitate and supplement the training opportunities provided to orthopedic residents. The use of VR simulators has increased rapidly in the field of medical surgery for training purposes. This paper discusses the creation of the virtual surgical environment (VSE) for training residents in an orthopedic surgical process called less invasive stabilization system (LISS) surgery which is used to address fractures of the femur. The overall methodology included first obtaining an understanding of the LISS plating process through interactions with expert orthopedic surgeons and developing the information centric models. The information centric models provided a structured basis to design and build the simulator. Subsequently, the haptic-based simulator was built. Finally, the learning assessments were conducted in a medical school. The results from the learning assessments confirm the effectiveness of the VSE for teaching medical residents and students. The scope of the assessment was to ensure (1) the correctness and (2) the usefulness of the VSE. Out of 37 residents/students who participated in the test, 32 showed improvements in their understanding of the LISS plating surgical process. A majority of participants were satisfied with the use of teaching Avatars and haptic technology. A paired t test was conducted to test the statistical significance of the assessment data which showed that the data were statistically significant. This paper demonstrates the usefulness of adopting information centric modeling approach in the design and development of the simulator. The assessment results underscore the potential of using VR-based simulators in medical education especially in orthopedic surgery.

Land use/land cover changes around Rameshwaram Island, east coast of India

Digital Repository Service at National Institute of Oceanography (India)

Gowthaman, R.; Dwarakish, G.S.; Sanilkumar, V.

Land-use/land cover changes are studied using the Indian Remote Sensing satellite (IRS-1C, IRS-6) Linear Image Self-scan Sensor (LISS) III data of 1998 and 2010 Coastal land use categories such as sand, vegetation, coral reef and water have been...

Education and support for representative, direct and stealth democracy

NARCIS (Netherlands)

Coffé, Hilde; Michels, Ank

2014-01-01

Using data collected within the scope of a Dutch internet panel survey (LISS) in 2011, this study tracks public support for direct, stealth and representative democracy according to educational level. Our findings indicate that, in terms of overall support for each specific type of democracy, lower

A time series approach to inferring groundwater recharge using the water table fluctuation method

Science.gov (United States)

Crosbie, Russell S.; Binning, Philip; Kalma, Jetse D.

2005-01-01

The water table fluctuation method for determining recharge from precipitation and water table measurements was originally developed on an event basis. Here a new multievent time series approach is presented for inferring groundwater recharge from long-term water table and precipitation records. Additional new features are the incorporation of a variable specific yield based upon the soil moisture retention curve, proper accounting for the Lisse effect on the water table, and the incorporation of aquifer drainage so that recharge can be detected even if the water table does not rise. A methodology for filtering noise and non-rainfall-related water table fluctuations is also presented. The model has been applied to 2 years of field data collected in the Tomago sand beds near Newcastle, Australia. It is shown that gross recharge estimates are very sensitive to time step size and specific yield. Properly accounting for the Lisse effect is also important to determining recharge.

Proof of shock-excited H2 in low-ionization structure of PNe

International Nuclear Information System (INIS)

Akras, Stavros; Gonçalves, Denise R.; Ramos-Larios, Gerardo

2016-01-01

We report the detection of near-IR H 2 line emission from the low-ionization structures (LISs) in planetary nebulae. The deepest, high-angular resolution H 2 1-0 S(1) at 2.122 μm, and H 2 2-1 S(1) at 2.248 μm images of K 4-47 and NGC 7662, obtained using NIRI@Gemini-North, are presented here. K 4-47 reveals a remarkable high-collimated bipolar structure, with the H 2 emission emanating from the walls of the outflows and a pair of knots at the tips of these outflows. The H 2 1-0 S(1)/2-1 S(1) line ratio is ∼⃒7-8 which indicates shock interaction due to both the lateral expansion of the gas and the high-velocity knots. The strongest line, H 2 v=1-0 S(1), is also detected in several LISs located at the periphery of the outer shell of the elliptical PN NGC 7662, whereas only four knots are detected in the H 2 v = 2-1 S(1) line. These knots have H 2 v = 1-0 S(1)/v = 2-1 S(1) values between 3 and 5. These data confirm the presence of molecular gas in both highly (K 4-47) and slowly moving LISs (NGC 7662). The H 2 emission in K 4-47 is powered by shocks, whereas in NGC 7662 is due to photo-ionization by the central star. Moreover, a likely correlation is found between the H 2 v = 1-0 S(1)/H 2 v = 2-1 S(1) and [N II]/Hα line ratios. (paper)

Can serological methods help distinguish between prophylactic and alloimmune anti-D?

Science.gov (United States)

Irving, C; Crennan, M; Vanniasinkam, T

2017-10-01

Enzyme indirect antiglobulin test (EIAT) and polyethylene glycol IAT (PIAT) were evaluated for their potential use as tests to distinguish between prophylactic and alloimmune anti-D in plasma by comparing with a tube variation of the standard low ionic strength solution-IAT (LISS-IAT). Laboratories performing the screening of RhD-negative pregnant women are required to provide clinicians with guidance as to the source of detected RhD antibodies. Currently, this is derived from RhIg immunoprophylaxis history, agglutination scores and titration results, where performed. A serological test that can differentiate between prophylactic and alloimmune anti-D would be useful in the diagnosis of RhD alloimmunisation in pregnant women. Plasma samples (n = 273) [fresh (collected from April 2014 to February 2015) and frozen (up to 2 years)] from antenatal females, preoperative males and females over child-bearing age were used in this study. Samples were identified as containing anti-D by routine column agglutination (CAT) and were tested by tube LISS-IAT, EIAT and PIAT, and a score difference was calculated. A total of 32% of alloimmune anti-D samples demonstrated an increase in agglutination score (+2 or +3) when tested by EIAT. A significant increase in agglutination score for alloimmune samples using EIAT compared with LISS-IAT was observed. EIAT had a sensitivity (Sn) of 59%, positive predictive value (PPV) of 100% and specificity (Sp) of 100% for alloimmune anti-D. EIAT is capable of confirming but not excluding the presence of alloimmune anti-D in samples where anti-D is detected in routine antibody screening. © 2017 British Blood Transfusion Society.

Silica Debris Star Systems — Spitzer Evidence for Lunar Formation Events & Crustal Stripping or Magma Oceans & Late Heavy Bombardments?

Science.gov (United States)

Lisse, C. M.; Chen, C. H.; Wyatt, M. C.; Morlok, A.; Thebault, P.; Orton, G. S.; Fletcher, L. N.; Fujiwara, H.; Bridges, J. C.; Elkins-Tanton, L. T.; Gaidos, E. J.; Trang, D.

2010-03-01

Recent work (Lisse et al., 2009) has detected amorphous silica and SiO gas around 12-m.y.-old HD172555, at the right age to form rocky planets. Here we discuss the location, lifetime, and source of the material, using inferences gleaned from HD172555 and three new silica systems.

Groeiremming als middel voor productie van visueel aantrekkelijke vaste planten : fosfaatvoeding als groeiremmer bij Salvia en Delphinium

NARCIS (Netherlands)

Aendekerk, T.G.L.

2007-01-01

Het onderzoek in de teelt naar gedrongen kwalitatief goede vaste planten is in 2006 gestart op het PPO op de locatie Lisse. In dit onderzoek wordt getracht het gewenste fosfaatniveau vast te stellen voor Delphinium cultorum ‘Dark Blue/White Bee' en Salvia nemorosa ‘Blaukoenigin’ om de groei te

Familial severe congenital neutropenia associated with infantile osteoporosis: a new entity.

Science.gov (United States)

Elhasid, R; Hofbauer, L C; Ish-Shalom, S; Ben-Arush, M; Koc, O; Rowe, J M; Etzioni, A

2003-01-01

A new entity manifested by severe congenital neutropenia associated with osteoporosis and recurrent bone fracture is described in a family. A possible role for a new recognized cytokine system involved in bone remodeling, the osteoprotegerin/receptor activator of nuclear factor-kappa B ligand, is suggested. Copyright 2002 Wiley-Liss, Inc.

Vowel Acoustics in Dysarthria: Mapping to Perception

Science.gov (United States)

Lansford, Kaitlin L.; Liss, Julie M.

2014-01-01

Purpose: The aim of the present report was to explore whether vowel metrics, demonstrated to distinguish dysarthric and healthy speech in a companion article (Lansford & Liss, 2014), are able to predict human perceptual performance. Method: Vowel metrics derived from vowels embedded in phrases produced by 45 speakers with dysarthria were…

2280-IJBCS-Article-Agbangba Codjo Emile

African Journals Online (AJOL)

hp

http://indexmedicus.afro.who.int. Influence de la fertilisation minérale sur la qualité physico-chimique et organoleptique du jus d'ananas transformé de Cayenne lisse au Bénin. Codjo Emile AGBANGBA 1,8*, Gustave Dieudonné DAGBENONBAKIN 2,. Coovi Paul DJOGBENOU2, Paul HOUSSOU 3, Emilienne Devi ASSEA 4,.

Holoprosencephaly: A mythologic and teratologic distillate.

Science.gov (United States)

Cohen, M Michael

2010-02-15

This review of holoprosencephaly provides a mythologic and teratologic distillate of the subject under the following headings: Babylonian tablets; Greek mythology; pictures from the 16th through the 20th Centuries; 19th Century teratology; history of more modern concepts and their terminologies; and ocean-going ships named "Cyclops." 2010 Wiley-Liss, Inc.

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

In this study, Gangotri glacier was monitored using Indian Remote Sensing (IRS) LISS-III sensor data in combination with field collected snow-meteorological data for a period of seven years (2001–2008). An overall decreasing trend in the areal extent of seasonal snow cover area (SCA) was observed. An upward shifting ...

Outcome prediction in pneumonia induced ALI/ARDS by clinical features and peptide patterns of BALF determined by mass spectrometry.

Science.gov (United States)

Frenzel, Jochen; Gessner, Christian; Sandvoss, Torsten; Hammerschmidt, Stefan; Schellenberger, Wolfgang; Sack, Ulrich; Eschrich, Klaus; Wirtz, Hubert

2011-01-01

Peptide patterns of bronchoalveolar lavage fluid (BALF) were assumed to reflect the complex pathology of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) better than clinical and inflammatory parameters and may be superior for outcome prediction. A training group of patients suffering from ALI/ARDS was compiled from equal numbers of survivors and nonsurvivors. Clinical history, ventilation parameters, Murray's lung injury severity score (Murray's LISS) and interleukins in BALF were gathered. In addition, samples of bronchoalveolar lavage fluid were analyzed by means of hydrophobic chromatography and MALDI-ToF mass spectrometry (MALDI-ToF MS). Receiver operating characteristic (ROC) analysis for each clinical and cytokine parameter revealed interleukin-6>interleukin-8>diabetes mellitus>Murray's LISS as the best outcome predictors. Outcome predicted on the basis of BALF levels of interleukin-6 resulted in 79.4% accuracy, 82.7% sensitivity and 76.1% specificity (area under the ROC curve, AUC, 0.853). Both clinical parameters and cytokines as well as peptide patterns determined by MALDI-ToF MS were analyzed by classification and regression tree (CART) analysis and support vector machine (SVM) algorithms. CART analysis including Murray's LISS, interleukin-6 and interleukin-8 in combination was correct in 78.0%. MALDI-ToF MS of BALF peptides did not reveal a single identifiable biomarker for ARDS. However, classification of patients was successfully achieved based on the entire peptide pattern analyzed using SVM. This method resulted in 90% accuracy, 93.3% sensitivity and 86.7% specificity following a 10-fold cross validation (AUC = 0.953). Subsequent validation of the optimized SVM algorithm with a test group of patients with unknown prognosis yielded 87.5% accuracy, 83.3% sensitivity and 90.0% specificity. MALDI-ToF MS peptide patterns of BALF, evaluated by appropriate mathematical methods can be of value in predicting outcome in pneumonia induced

Antibodies to co-trimoxazole (trimethoprim and/or sulfamethoxazole) related to the presence of the drug in a commercial low-ionic-strength solution.

Science.gov (United States)

Pham, Bach-Nga; Gien, Dominique; Bensaad, Farid; Babinet, Jérome; Dubeaux, Isabelle; Rouger, Philippe; Le Pennec, Pierre-Yves

2012-04-01

Drug-dependent antibodies have been associated with approximately 10% of acquired immune hemolytic anemia cases. These antibodies are a rare cause of interference in pretransfusion red blood cell (RBC) serologic testing. The aim of this work was to report three cases of subjects developing antibodies against co-trimoxazole, a combination of trimethoprim (TMP) and sulfamethoxazole (SMX). Blood samples of donor/patients were referred to our laboratory for the exploration of a positive antibody detection test. There was no recent history of drug taking. Antibody identification was performed by gel test using an indirect antiglobulin test, with reagent RBCs in low-ionic-strength solutions (LISS) containing co-trimoxazole or not. All three sera showed positive reactions when RBCs were resuspended in LISS containing co-trimoxazole, but negative reactions when RBCs were resuspended in LISS without antibiotic. We detected antibodies against co-trimoxazole showing three different antibody patterns: anti-TMP plus anti-SMX, anti-TMP alone, or anti-SMX alone. Anti-TMP showed an apparent anti-Ku specificity in the two cases where it was present. Anti-SMX showed an apparent anti-H specificity in one of the two cases described. The drug-dependent antibodies were not associated with acquired hemolytic anemia or other pathologies. Antibodies against co-trimoxazole may only be detected when using a diluent for reagent RBCs containing the drug in question. Antibody pattern (anti-TMP and/or anti-SMX) may vary according to individuals' immune response. Drug-dependent antibodies may react as antibodies against a high-prevalence antigen, supporting the hypothesis of antibodies to drug and membrane components. Drug-dependent antibodies such as anti-co-trimoxazole may be a serologic finding without clinical features. © 2011 American Association of Blood Banks.

Assembly of primary cilia

DEFF Research Database (Denmark)

Pedersen, Lotte B; Veland, Iben R; Schrøder, Jacob M

2008-01-01

knowledge about IFT is based on studies performed in Chlamydomonas and Caenorhabditis elegans. Therefore, our review of the IFT literature includes studies performed in these two model organisms. The role of several non-IFT proteins (e.g., centrosomal proteins) in the ciliary assembly process is also...... discussed. Developmental Dynamics, 2008. (c) 2008 Wiley-Liss, Inc....

ÉTUDE SUR LES CAPACITÉS DE FRANCHISSEMENT DES CABOTS BOUCHE-RONDES (SICYOPTERUS LAGOCEPHALUS, PALLAS, 1770 EN VUE DE LA CONCEPTION DE DISPOSITIFS ADAPTÉS AUX PRISES D’EAU DU TRANSFERT SALAZIE (ÎLE DE LA REUNION.

Directory of Open Access Journals (Sweden)

VOEGTLÉ B.

2002-01-01

puissent franchir un mur vertical, le pourcentage de passage et le taux de réussite est beaucoup plus faible que pour les autres pentes testées. Une pente à 50°, et une charge de l’ordre de 1-2 mm sont les deux conditions ayant permis sur le pilote d’obtenir les meilleurs résultats. Le revêtement de la rampe s’est révélé être un facteur secondaire, le béton lisse constituant cependant le meilleur support. Les résultats de cette étude ont permis de proposer des critères de dimensionnement pour des dispositifs de franchissement adaptés aux sites et à l’espèce. La passe consiste en une rampe en béton lisse installée à une pente de 50° alimentée par déversement. Une alimentation non uniforme sur la largeur de la rampe permet d’obtenir, quel que soit le niveau amont, une zone favorable à la remontée du poisson.

Comet LINEAR C/1999 S4 - an absolutely well-behaved comet before breakup

Science.gov (United States)

Peschke, S. B.; Lisse, C. M.; Fernandez, Y. R.; Ressler, M.; Stickel, M.; Kaminski, C.; Golish, B.

2000-10-01

We present results from infrared imaging of comet LINEAR C/1999 S4 on June 17 - 19, 2000 (pre-breakup), using the near-IR camera NSFCAM and the mid-IR camera MIRLIN at the 3m NASA/IRTF. Images and multi-wavelength spectroscopy were obtained in the zJHK'L'MNQ bands, and were used to create a 1.0 - 25 μ m SED of the comet's dust and nucleus. The coma's contribution at each wavelength was modeled using spatial fitting (Fernandez 1999, PhD thesis; Lisse et al. 1999, Icarus 140, 189). The resulting comatic and nuclear SEDs were then modeled using modified Mie theory (Lisse et al. 1998, ApJ 496, 971) and the standard nuclear thermal models (Lebofsky and Spencer 1989, Asteroids II, 128), respectively. We report the resulting dust PSD, mass loss rate, and albedo, as well as the nuclear radius, and we compare these results to those obtained by others from optical data both before and after the comet's breakup in late July 2000.

Are Final Comments in Web Survey Panels Associated with Next-Wave Attrition?

Directory of Open Access Journals (Sweden)

Cynthia McLauchlan

2016-12-01

Full Text Available Near the end of a web survey respondents are often asked whether they have further comments. Such final comments are usually ignored, in part because open-ended questions are challenging to analyse. We explored whether final comments are associated with next-wave attrition in survey panels. We categorized a random sample of final comments in the Longitudinal Studies for the Social Sciences (LISS panel and Dutch Immigrant panel into one of eight categories (neutral, positive, six subcategories of negative and regressed the indicator of next-wave attrition on comment length, comment category and socio-demographic variables. In the Immigrant panel we found shorter final comments (55 words with decreased next-wave attrition relative to making no comment. Comments about unclear survey questions quadruple the odds of attrition and “other” (uncategorized negative comments almost double the odds of attrition. In the LISS panel, making a comment (vs. not and comment length are not associated with attrition. However, when specifying individual comment categories, neutral comments are associated with half the odds of attrition relative to not making a comment.

Morphology and evolutionary implications of the annual cycle of secretion and sperm storage in spermathecae of the salamander Ambystoma opacum (Amphibia: Ambystomatidae).

Science.gov (United States)

Sever, David M; Krenz, John D; Johnson, Kristin M; Rania, Lisa C

1995-01-01

Females of the marbled salamander, Ambystoma opacum, store sperm in exocrine glands called spermathecae in the roof of the cloaca. Eggs are fertilized by sperm released from the spermathecae during oviposition. Some sperm remain in the spermathecae following oviposition, but these sperm degenerate within a month and none persists more than 6 mo after oviposition. Thus, sperm storage between successive breeding seasons does not occur. Apical secretory vaculoes are abundant during the fall mating season and contain a substance that is alcian blue+ at pH 2.5. Production of secretory vacuoles decreases markedly after oviposition, and the glands are inactive by the summer months. Ambystoma opacum is a terrestrial breeder, and some mating occurs prior to arrival at pond basins where oviposition occurs. Mating prior to arrival at the ovipository site may prolong the breeding season, leading to fitness implications for both males and females. Females have opportunities for more matings, and the possibilities for sperm competition in the spermathecae are enhanced. © 1995 Wiley-Liss, Inc. Copyright © 1995 Wiley-Liss, Inc.

377 Konan et al., Afr J Tradit Complement Altern Med. (2011) 8(4 ...

African Journals Online (AJOL)

AJTCAM

aurantifolia (Rutaceae) sur le muscle lisse, Taenia coli de cobaye. Rev. Med. Pharm. Afr. 16: 103-112. 35. Souza, A., Aka, K.J., Abo, K.J.C., Datté, Y.J., Traoré, F. and M'Batchi, B. (2007). Myostimulating effect of the aqueous extract of Khaya senegalensis (Desr) A. Juss (Meliaceae) in isolated Taenia caeci contractile activity.

Original Paper Etude des effets vermicide et anti-diarrhéique du ...

African Journals Online (AJOL)

lisse intestinal qui serait due, soit à une inhibition de l'influx calcique, soit à une augmentation de l'efflux de calcium sans modification de l'influx ou même à une capture du Ca2+ libre cytoplasmique. Effet des concentrations croissantes du macéré aqueux des feuilles de Salvadora persica, L. sur la contracture induite par.

2520-IJBCS-Article-Emile N Houngbo

African Journals Online (AJOL)

hp

Agadès) et l'oignon Dendi de Malanville (ou oignon rouge, oignon local). Les caractéristiques qui les distinguent sont les suivantes. L'oignon de Galmi : Moyennement gros par rapport à l'oignon rouge ; peau relativement lisse ; moins difficile à conserver; moins piquant (moins acide) ; donne une saveur agréable à la sauce ...

risk factors of active tuberculosis in people living with hiv/aids in ...

African Journals Online (AJOL)

Abrham

2011-07-02

Jul 2, 2011 ... R, Lisse I, Samb B et al: Tuberculosis in. Bissau: incidence and risk factors in an urban community in sub-Saharan Africa. Int J. Epidemiol 2004;33(1):163-172. 10. MOH: TB, leprosy and TB/HIV prevention and control program manual. Addis Ababa,. Ethiopia. 2008. 11. Fugnudo Mbeki AG, Kuwala Lube: ...

Cellular Effects of Endotoxin in Vitro: Mobility of Endotoxin in the Plasma Membrane of Hepatocytes and Neuroblastoma Cells

Science.gov (United States)

1985-01-01

initiates ain.otoxin eqxpocar In the pteet work. we have celular perturbations. remains to be determined. I In vivo stdahawe shown that the liver is an...1977) Scismos 195. 307-309 tomn at the Celular LAve (Majde. JA.. ad.). Mp 81-95. 30 SdchminW. J., SebchaW. Y- Casacasas. P. Wminsa Alan I. Liss. New

Contrôle des germes endogènes par usage d'agents antimicrobiens ...

African Journals Online (AJOL)

SARAH

31 janv. 2018 ... lisse (Hilo et Saint Michael) et Pain de sucre ont été ensemencés sur le milieu de Murashige et Skoog additionné de 5 mg/l ... In this study, the effects of ...... Impact of Thermotherapy And Chlorothalonil On. Plantlets Production Of Some Genotypes Of. Cassava (Manihot Esculenta Crantz) Produce In. Benin.

Study of a case of essential hypoproteinaemia using the isotopes {sup 131}I and {sup 15}N; Etude a l'aide des isotopes {sup 131}I et {sup 15}N d'un cas d'hypoproteinemie essentielle

Energy Technology Data Exchange (ETDEWEB)

Dubert, A; Coursaget, J; Fallot, P; Royer, P [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires; Hopital des Enfants Malades, 75 - Paris (France)

1959-07-01

Hypoproteinaemia both human and experimental has been studied with the help of nuclear labelling. A comparative study has been made of the fate of serum proteins labelled by an endogenous path after administration of nitrogen-15 glycine and also of serum albumin labelled by exogenous path using iodine-131. We have determined the biological period of the serum albumin and serum globulins and also the magnitude of the vascular and extravascular pools of serum albumin. In this way it has been possible to measure the speed of replacement of plasma proteins. A presentation of results taken from both clinical observation and experiment leads to a discussion on the pathogenic mechanism of hypoproteinaemia. (author) [French] Les hypoproteinemies humaine et experimentale ont ete explorees a l'aide d'indicateurs nucleaires. Une etude comparative du devenir des proteines seriques marquees par voie endogene, apres administration de glycocolle-{sup 15}N et de l'albumine serique marquee par voie exogene a l'iode-131 a ete realisee. On a determine la periode biologique de la serumalbumine et des globulines seriques ainsi que la grandeur des 'pools' vasculaire et extravasculaire de la serumalbumine. Il a ete ainsi possible d'evaluer la vitesse de renouvellement des proteines plasmatiques. La confrontation des resultats tires de l'observation clinique et de l'experimentation conduit a une discussion sur le mecanisme pathogenique de l'hypoproteinemie. (auteur)

Keck i LWS Mid-Ir Images and Photometry of 9P/TEMPEL 1

Science.gov (United States)

Fernandez, Y. R.; Lisse, C. M.; A'Hearn, M. F.; Belton, M. J. S.

2010-01-01

This data set contains raw and reduced mid-infrared images and photometry of comet 9P/Tempel 1, the target of the Deep Impact mission. Images were acquired on the night of 21 August 2000, about 7.5 months after perihelion, by Y. Fernandez, C. Lisse, M. A'Hearn and M. Belton using the Long Wavelength Spectrometer instrument at the Keck I telescope.

2048-IJBCS-Article-Elvire Sossa

African Journals Online (AJOL)

hp

Soixante-quinze pour cent des producteurs d'ananas du plateau d'Allada sont analphabètes et cultivent l'ananas depuis. 9,1±4,8 ans. La plupart de ces producteurs. (90,4%) n'appartiennent à aucune association socioprofessionnelle. Les variétés d'ananas cultivées sont le pain de sucre et la cayenne lisse. La superficie ...

Mise au point

African Journals Online (AJOL)

région épigastrique de taille 15-10 cm, non douloureuse à la palpation, ferme, de contour régulier et à surface lisse. Devant ce tableau, nous avons réalisé : J. TUN ORL - N° 20 JUIN 2008. 62. LYMPHOME DE BURKITT PÉDIATRIQUE. À RÉVÉLATION ORL : QUELLE PRISE EN CHARGE EN MILIEU SUB SAHÉLIEN ?

The origin of pits on 9P/Tempel 1 and the geologic signature of outbursts in Stardust-NExT images

Science.gov (United States)

Belton, Michael J. S.; Thomas, Peter; Carcich, Brian; Quick, Andrew; Veverka, Joseph; Jay Melosh, H.; A'Hearn, Michael F.; Li, Jian-Yang; Brownlee, Donald; Schultz, Peter; Klaasen, Kenneth; Sarid, Gal

2013-02-01

We consider the origin of ˜380 quasi-circular depressions (pits) seen to be distributed in a broad band across the surface of 9P/Tempel 1 and show that possibly ˜96% may be due to outburst activity. Of the rest, Lisse, C.M., Holloway, M., Rho, J. [2010]. Icarus 208, 276-292) based on IR observations of 17P.

Characterizing the X-ray Radiation Field in the Earth-like Planet Forming ExoSystem HD 113766

Science.gov (United States)

Lisse, Carey

2010-09-01

We propose a 100 ksec ACIS-S observation of the 12 Myr old system HD 113766, the site of on-going terrestrial planet formation (Lisse et al. 2008), in order to determine the spectrum of x-ray radiation in the fledgling system, its origin in the stellar coronae and proto-planetary disk, and its potential impact on the nascent planet.

1 Étude numérique de la convection naturelle tridimensionnelle ...

African Journals Online (AJOL)

TOSHIBA

naturelle thermique laminaire de type couche limite au voisinage d'un cône à surface lisse. Bapuji et al. [2] ont étudié le courant de la convection naturelle laminaire instable avec un cône vertical isotherme. Pop et. Tsung Yen [3] ont étudié les effets de la compressibilité dans la convection naturelle laminaire autour d'un.

Comparison of Wood Preservatives in Stake Tests (1983 Progress Report).

Science.gov (United States)

1983-12-01

to "X-disease" (hyperkeratosis) in cattle . These oils are therefore not recommended for preservative treatment of wood with which cattle 4 may come in...welam Molmol(W sies saidal) liss. 6.1 of- - - - a. - 0 a . .F a e o a mWi is . 0 .1 a s - - - - - m - - * - l e t a 1 4i .8 blawaeted castrate asis

Fulltext PDF

Indian Academy of Sciences (India)

The picture is that of Interview Island in the Anda- mans chain as seen by the lISS III sensor of IR5-1D on 26 January 2000. The island 1133 sq km) is covered with dense and evergreen tropical forests, and is bordered with coral reefs, sea grasses and seaweed patches. The dense red colour depicts healthy vegetation of ...

Implication des vésicules extracellulaires des cellules initiatrices tumorales dans l’augmentation de la perméabilité vasculaire du glioblastome

OpenAIRE

Treps , Lucas

2015-01-01

Brain microvessels are characterized by specific structure and organization within the neurovascular unit. Through highly selective endothelial junctions, the blood-brain barrier (BBB) controls exchanges of cells, fluids, plasmatic proteins and metabolites between blood and the cerebral compartment. VE-cadherin, a transmembrane protein of endothelial junctions, is of most importance in the vascular integrity. Indeed, its destabilization leads to BBB weakening and also breaking in some patholo...

Intérêts de la description des variantes vasculaires avant chirurgie hépatique pancréatique et rénale

OpenAIRE

Leloup , Sarah Smahel

2015-01-01

Non disponible / Not available; Une imagerie complète associant au moins un scanner multi-phasique et une IRM doit être réalisée avant toute chirurgie hépatique (pour carcinome hépato-cellulaire ou métastasectomie hépatique), transplantation hépatique, duodéno-pancréatectomie céphalique, et avant toute greffe rénale. Elle n’a plus seulement pour but de fournir des éléments de caractérisation lésionnelle, elle devient à la base du bilan de résécabilité des lésions et d’opérabilité des patients...

Cometary X-rays - the View After the First Chandra Cycle

Science.gov (United States)

Lisse, Carey M.

2001-09-01

The unexpected discovery of x-ray emission from Comet Hyakutake in March 1996 (Lisse et al. 1996) has produced a number of questions about the physical mechanism producing the radiation. The original detection and subsequent observations (Dennerl et al. 1997, Mumma et al. 1997, Krasnopolsky et al. 1998, Owens et al. 1998, Lisse et al. 1999) have shown that the very soft (best fit thermal bremsstrahlung model kT 0.2 keV) emission is due to an interaction between the solar wind and the comet's atmosphere. Using the results from the 15 comets detected to date in x-rays, we report on the latest results on cometary x-ray emission, including new results from Chandra and XMM. As-observed morphologies, spectra, and light curves will be discussed. Our emphasis will be on understanding the physical mechanism producing the emission, and using this to determine the nature of the cometary coma, the structure of the solar wind in the heliosphere, and the source of the local soft x-ray background. This work has been graciously supported by grants from the NASA Planetary Astronomy and Astrophysical Data Programs.

Multiwavelength Photometric Imaging of X-Ray and EUV Emission from Comet P/Tempel-Tuttle 1998

Science.gov (United States)

Lisse, Carey M.

2004-01-01

The unexpected discovery of x-ray emission from Comet Hyakutake in March 1996 (Lisse et ai. 1996) has produced a number of questions about the physical mechanism producing the radiation. The original detection and subsequent observations (Dennerl et ai. 1997, Mumma et al. 1997, Krasnopolsky et al. 1998, Owens et al. 1998. Lisse et al. 1999) have shown that the very soft (best fit thermal bremsstrahlung model kT approx. 0.2 keV) emission is due to an interaction between the solar wind and the comet's atmosphere. Using the results fiom the 15 comets detected to date in x-rays, we report on the latest results on cometary x-ray emission, including new results from Chandra and XMM. As-observed morphologies, spectra, and light curves will be discussed. Our emphasis will be on understanding the physical mechanism producing the emission, and using this to determine the nature of the cometary coma, the structure of the solar wind in the heliosphere, and the source of the local soft x-ray background. This work has been graciously supported by grants from the NASA Planetary Astronomy and Astrophysical Data Programs.

Cometary X-ray Emission: the View After the First Chandra Observations

Science.gov (United States)

Lisse, C. M.

2002-01-01

The unexpected discovery of x-ray emission from Comet Hyakutake in March 1996 (Lisse et al. 1996) has produced a number of questions about the physical mechanism producing the radiation. The original detection and subsequent observations (Dennerl et al. 1997, Mumma et al. 1997, Krasnopolsky et al. 1998, Owens et al. 1998, Lisse et al. 1999) have shown that the very soft (best fit thermal bremsstrahlung model kT ~ 0.2 keV) emission is due to an interaction between the solar wind and the comet's atmosphere. Using the results from the 15 comets detected to date in x-rays, we report on the latest results on cometary x-ray emission, including new results from Chandra and XMM. As-observed morphologies, spectra, and light curves will be discussed. Our emphasis will be on understanding the physical mechanism producing the emission, and using this to determine the nature of the cometary coma, the structure of the solar wind in the heliosphere, and the source of the local soft x-ray background. This work has been graciously supported by grants from the NASA Planetary Astronomy and Astrophysical Data Programs.

Christianity, health, and genetics.

Science.gov (United States)

Smith, David H

2009-02-15

Health is an intrinsic value that Christians should respect, but it is not the highest value. Christians should be willing to jeopardize their own health for the health of others, and should repudiate any idea that genetic problems are the result of sin. Rather, sin leads us to make genetic problems harder to live with than they should be. (c) 2009 Wiley-Liss, Inc.

Untitled

African Journals Online (AJOL)

5 cm de la marge anale, à surface lisse et. Le tératome est une tumeur qui se contours réguliers. développe au dépend de trois cellules souches embryonnaires (ectodermiques, L'échographie abdominopelvienne a endodermiques et mésodermique)". Il siège le montré une masse rétrovésicale, homogène, plus souvent au ...

Etudes phytochimique et pharmacologique de Bridelia ferruginea ...

African Journals Online (AJOL)

L'extrait aqueux de Bridelia ferruginea provoque entre 10-5mg/mL et 10-1mg/mL une augmentation des contractions rythmiques de muscle lisse Taenia coli de cobaye. Ces effets inotropes positifs antagonisés par l'Atropine (10-6mg/mL) sont totalement abolis en milieu pauvre (0Ca2+) et dépourvus de calcium (0Ca2++ ...

KYSTE DERMOÏDE DU PLANCHER BUCCAL

African Journals Online (AJOL)

18 juin 2007 ... molle, indolore bien limitée, sessile ou pédiculée, lisse avec un aspect jaune caractéristique[10]. La palpation bidigitale, l'échographie associée à une ponc- tion cytologique, le scanner et au mieux l'IRM sont essen- tiels pour l'orientation étiologique devant toute lésion du plancher buccal [8]. En effet, l'IRM ...

Analytical techniques and quality control in biomedical trace element research

DEFF Research Database (Denmark)

Heydorn, K.

1994-01-01

The small number of analytical results in trace element research calls for special methods of quality control. It is shown that when the analytical methods are in statistical control, only small numbers of duplicate or replicate results are needed to ascertain the absence of systematic errors....../kg. Measurement compatibility is obtained by control of traceability to certified reference materials, (C) 1994 Wiley-Liss, Inc....

Outcome prediction in pneumonia induced ALI/ARDS by clinical features and peptide patterns of BALF determined by mass spectrometry.

Directory of Open Access Journals (Sweden)

Jochen Frenzel

Full Text Available BACKGROUND: Peptide patterns of bronchoalveolar lavage fluid (BALF were assumed to reflect the complex pathology of acute lung injury (ALI/acute respiratory distress syndrome (ARDS better than clinical and inflammatory parameters and may be superior for outcome prediction. METHODOLOGY/PRINCIPAL FINDINGS: A training group of patients suffering from ALI/ARDS was compiled from equal numbers of survivors and nonsurvivors. Clinical history, ventilation parameters, Murray's lung injury severity score (Murray's LISS and interleukins in BALF were gathered. In addition, samples of bronchoalveolar lavage fluid were analyzed by means of hydrophobic chromatography and MALDI-ToF mass spectrometry (MALDI-ToF MS. Receiver operating characteristic (ROC analysis for each clinical and cytokine parameter revealed interleukin-6>interleukin-8>diabetes mellitus>Murray's LISS as the best outcome predictors. Outcome predicted on the basis of BALF levels of interleukin-6 resulted in 79.4% accuracy, 82.7% sensitivity and 76.1% specificity (area under the ROC curve, AUC, 0.853. Both clinical parameters and cytokines as well as peptide patterns determined by MALDI-ToF MS were analyzed by classification and regression tree (CART analysis and support vector machine (SVM algorithms. CART analysis including Murray's LISS, interleukin-6 and interleukin-8 in combination was correct in 78.0%. MALDI-ToF MS of BALF peptides did not reveal a single identifiable biomarker for ARDS. However, classification of patients was successfully achieved based on the entire peptide pattern analyzed using SVM. This method resulted in 90% accuracy, 93.3% sensitivity and 86.7% specificity following a 10-fold cross validation (AUC = 0.953. Subsequent validation of the optimized SVM algorithm with a test group of patients with unknown prognosis yielded 87.5% accuracy, 83.3% sensitivity and 90.0% specificity. CONCLUSIONS/SIGNIFICANCE: MALDI-ToF MS peptide patterns of BALF, evaluated by appropriate

The different intracellular action potentials of fast and slow muscle fibres = Différences entre les potentiels d'action intracellulaires de fibres musculaires rapides et lentes

NARCIS (Netherlands)

Wallinga, W.; Gielen, Frans L.H.; Wirtz, Peter; de Jong, Paul; Broenink, Johannes F.

1985-01-01

The time course of the intracellular action potential was studied quantitatively, because it is an important factor in the generation of electromyographic signals. In in vivo preparations of the m. EDL and m. soleus of the rat single motor units were stimulated and intracellular action potentials

Photosynthetic Responses to the Environment. Proceedings Symposium held August 24 - 27, 1992. Volume 8

Science.gov (United States)

1992-08-27

seedlings were grown in Wagner pots that were filled with 5 continuously aerated hydroponic solutions of various nitrate concentrations according to Hewitt...seeded Simpson, were grown by hydroponics inside Conviron growth chambers (model E15). The description of the hydroponic system, the growth solutions , and...control. In Briggs WR ed, Photosynthesis, Alan R Liss, New York, pp 183-205 8. Evans JR, Terashlma I (1988) Photosynthetic characteristics of spinach

Phanéroptique et zoométrie chez quatre types génétiques de poules ...

African Journals Online (AJOL)

Le plumage est de type lisse (69,9%) ou soyeux superficiel (30,1%). Le type génétique à l'emplumement normal est largement représenté (66,0%), suivi du tarse emplumé (22,9%), huppé (10,0%) et une minorité de cou-nus (1,1%). Les crêtes, à prédominance de type simple (81,1%) ont une coloration essentiellement ...

2087-IJBCS-Article-Fanou André

African Journals Online (AJOL)

admin

cayenne lisse au champ à Loto-Dénou, Allada en conditions d'infestation naturelle et dans la serre à l'Institut. International d'Agriculture Tropicale station du Bénin où les cochenilles ont été multipliées sur les fruits de potiron pour être lâchées à raison de 20 insectes par plant avant la pulvérisation des produits. Après.

Algérie

African Journals Online (AJOL)

PR BOKO

Le fruit est une baie ovale, sèche et lisse. C'est une plante ayant des qualités et des propriétés stimulantes antiseptiques et insecticides. Il sert à la fabrication des parfums. Rosmarinus officinalis est retrouvée même à l'état sauvage. Il peut être cultivé. La position systématique de cette espèce est : Ordre. Lamiales. Famille.

STUDY OF THE SEMI-THEORETICAL RELATION OF THE ...

African Journals Online (AJOL)

comparative avec le ressaut hydraulique en canal profilé en 'U' à fond lisse sera également proposée. Les caractéristiques adimensionnelles du ressaut, concernées par cette étude sont les suivantes : le nombre de Froude IF1; le débit relatif Q* ; la hauteur relative S = s/h1 du seuil à paroi mince ; la longueur relative Lj/h1 ...

Café-au-lait macules and pediatric malignancy caused by biallelic mutations in the DNA mismatch repair (MMR) gene PMS2.

Science.gov (United States)

Jackson, Carl-Christian; Holter, Spring; Pollett, Aaron; Clendenning, Mark; Chou, Shirley; Senter, Leigha; Ramphal, Raveena; Gallinger, Steven; Boycott, Kym

2008-06-01

A 14-year-old male presented with a T4 sigmoid adenocarcinoma, PMS2 protein and high frequency microsatellite instability. Germline analysis identified biallelic PMS2 missense mutations. A new cancer syndrome caused by biallelic mutations in the mismatch repair genes, including PMS2, is now emerging and is characterized by café-au-lait macules, colonic polyps and a distinctive tumor spectrum. (c) 2007 Wiley-Liss, Inc.

Saphenous vein grafts for perforator flap salvage in autologous breast reconstruction.

Science.gov (United States)

Flores, Jaime I; Rad, Ariel N; Shridharani, Sachin M; Stapleton, Sahael M; Rosson, Gedge D

2009-01-01

Although the use of saphenous vein grafts in free-flap salvage and extremity replantation is relatively common, their use in breast reconstruction is rare. These two case reports represent extreme alternatives for breast reconstruction flap salvage. In our normal daily practice, the overwhelming majority of elective breast reconstructions proceed smoothly. However, the occasional patient may require saphenous vein graft flap rescue for completion of the reconstruction. (c) 2008 Wiley-Liss, Inc.

Duplication 4p and deletion 4p (Wolf-Hirschhorn syndrome) due to complementary gametes from a 3:1 segregation of a maternal balanced t(4;13)(p16;q11) translocation.

Science.gov (United States)

Takeno, S S; Corbani, M; Andrade, J A D; Smith, M de A C; Brunoni, D; Melaragno, M I

2004-08-30

We present clinical and cytogenetic data on a family with a t(4;13)(p16;q11) translocation present in four generations. The balanced translocation resulted in one individual with monosomy 4p and one individual with trisomy 4p, due to 3:1 segregation. The male patient with trisomy 4p was fertile and transmitted the extra chromosome to his daughter. Copyright 2004 Wiley-Liss, Inc.

Deracemization of bilirubin as the marker of the chirality of micellar aggregates.

Science.gov (United States)

Sorrenti, Alessandro; Altieri, Barbara; Ceccacci, Francesca; Di Profio, Pietro; Germani, Raimondo; Giansanti, Luisa; Savelli, Gianfranco; Mancini, Giovanna

2012-01-01

The deracemization of bilirubin in micellar aggregates of structurally correlated chiral surfactants was studied by circular dichroism experiments and exploited as the marker of the expression of chirality of the aggregates. The obtained results suggest that the hydrophobic interactions control the transfer of chirality from the monomers to the aggregates, and that different regions of the same aggregate might feature opposite enantiorecognition capabilities. Copyright © 2011 Wiley-Liss, Inc.

Inflammatory pseudotumor of the liver: ferumoxide-enhanced MR imaging as a tiebreaker.

Science.gov (United States)

Kato, Hiroki; Kanematsu, Masayuki; Kondo, Hiroshi; Osada, Shinji; Goshima, Satoshi; Yamada, Tetsuya; Yamada, Yasuhiro; Yokoyama, Ryujiro; Hoshi, Hiroaki; Moriyama, Noriyuki

2004-09-01

We examined a 70-year-old male patient with an inflammatory pseudotumor of the liver mimicking a peripheral-type cholangiocellular carcinoma. Ferumoxide-enhanced magnetic resonance (MR) imaging revealed residual Kupffer cell function in liver parenchyma in and surrounding the inflammatory pseudotumor involvement, which suggested the diagnosis of inflammatory pseudotumor of the liver. We correlate the MR imaging and pathologic findings in this report. Copyright 2004 Wiley-Liss, Inc.

Profil épidémiologique de l'insuffisance rénale terminale à l'hôpital Militaire de Rabat, Maroc

Science.gov (United States)

Asserraji, Mohammed; Maoujoud, Omar; Belarbi, Marouane; Oualim, Zouhir

2015-01-01

L'Insuffisance rénale chronique terminale (IRCT) est un enjeu majeur de sante publique au Maroc à cause de ses conséquences médicales et socioéconomiques. L'objectif de ce travail est d’évaluer le profil épidémiologique de l'IRCT à l'hôpital militaire de rabat, Maroc. Il s'agit d'une enquête rétrospective pendant quatre ans (1er janvier 2007 au 31 décembre 2010). Tous les cas d'IRCT (diminution permanente du débit de filtration glomérulaire (DFG) < 15 ml/min/1.73m2, pendant ≥ 3 mois) ont été inclus. 203 patients ont commencé la dialyse durant cette période, 130 hommes (64%) et 73 femmes (36%), l’âge moyen était de 49,92 ans (06 - 80 ans). la néphropathie d'origine indéterminée représente la première cause d'IRCT dans notre série (27,1%) suivie de la néphropathie diabétique (24,6%), des glomérulonéphrites chroniques (22,7) et de la néphropathie d'origine vasculaire (10,8%). 131 patients (64,5%) n'ont pas eu de suivi néphrologique pré dialytique. une prise en charge globale de cette pathologie est nécessaire. PMID:26309471

Study of a case of essential hypoproteinaemia using the isotopes {sup 131}I and {sup 15}N; Etude a l'aide des isotopes {sup 131}I et {sup 15}N d'un cas d'hypoproteinemie essentielle

Energy Technology Data Exchange (ETDEWEB)

Dubert, A.; Coursaget, J.; Fallot, P.; Royer, P. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires; Hopital des Enfants Malades, 75 - Paris (France)

1959-07-01

Hypoproteinaemia both human and experimental has been studied with the help of nuclear labelling. A comparative study has been made of the fate of serum proteins labelled by an endogenous path after administration of nitrogen-15 glycine and also of serum albumin labelled by exogenous path using iodine-131. We have determined the biological period of the serum albumin and serum globulins and also the magnitude of the vascular and extravascular pools of serum albumin. In this way it has been possible to measure the speed of replacement of plasma proteins. A presentation of results taken from both clinical observation and experiment leads to a discussion on the pathogenic mechanism of hypoproteinaemia. (author) [French] Les hypoproteinemies humaine et experimentale ont ete explorees a l'aide d'indicateurs nucleaires. Une etude comparative du devenir des proteines seriques marquees par voie endogene, apres administration de glycocolle-{sup 15}N et de l'albumine serique marquee par voie exogene a l'iode-131 a ete realisee. On a determine la periode biologique de la serumalbumine et des globulines seriques ainsi que la grandeur des 'pools' vasculaire et extravasculaire de la serumalbumine. Il a ete ainsi possible d'evaluer la vitesse de renouvellement des proteines plasmatiques. La confrontation des resultats tires de l'observation clinique et de l'experimentation conduit a une discussion sur le mecanisme pathogenique de l'hypoproteinemie. (auteur)

Measurement and computation for sag of calandria tube due to irradiation creep in PHWR

International Nuclear Information System (INIS)

Son, S. M.; Lee, W. R.; Lee, S. K.; Lee, J. S.; Kim, T. R.; Na, B. K.; Namgung I.

2003-01-01

Calandria tubes and Liquid Injection Shutdown System(LISS) tubes in a Pressurized Heavy Water Reactor(PHWR) are to sag due to irradiation creep and growth during plant operation. When the sag of calandria tube becomes bigger, the calandria tube possibly comes in contact with LISS tube crossing beneath the calandria tube. The contact subsequently may cause the damage on the calandria tube resulting in unpredicted outage of the plant. It is therefore necessary to check the gap between the two tubes in order to periodically confirm no contact by using a proper measure during the plant life. An ultrasonic gap measuring probe assembly which can be inserted into two viewing ports of the calandria was developed in Korea and utilized to measure the sags of both tubes in the PHWR. It was found that the centerlines of calandria tubes and liquid injection shutdown system tubes can be precisely detected by ultrasonic wave. The gaps between two tubes were easily obtained from the relative distance of the measured centerline elevations of the tubes. Based on the irradiation creep equation and the measurement data, a computer program to calculate the sags was also developed. With the computer program, the sag at the end of plant life was predicted

Computation and measurement of calandria tube sag in PHWR

International Nuclear Information System (INIS)

Kim, Tae Ryong; Sohn, Seok Man

2003-01-01

Calandria tubes and liquid injection shutdown system (LISS) tubes in a pressurized heavy water reactor (PHWR) is known to sag due to irradiation creep and growth during plant operation. When the sag of calandria tube becomes bigger, the calandria tube possibly comes in contact with LISS tube crossing beneath and calandria tube. The contact subsequently may cause the damage on the calandria tube resulting in unpredicted outage of the plant. It is therefore necessary to check the gap between the two tubes in order to periodically confirm no contact by using a proper measure during the plant life. An ultrasonic gap measuring probe assembly which can be inserted into two viewing ports of the calandria was developed in Korea and utilized to measure the sags of both tubes in the PHWR. It was found that the centerlines of calandria tubes and liquid injection shutdown system tubes can be precisely detected by ultrasonic wave. The gaps between two tubes were easily obtained from the relative distance of the measured centerline elevations of the tubes. Based on the irradiation creep equation and the measurement data, a computer program to calculate the sags was also developed. With the computer program, the sag at the end of plant life was predicted. (author)

Results from the UMD physical properties of comets survey

Science.gov (United States)

Lisse, Carey M.; A'Hearn, Michael F.; Fernandez, Yanga R.

2005-01-01

We report on an ongoing statistical study of the emitted dust and exposed nuclei of a survey of the brightest near-Earth comets over the last 13 years. Combined thermal infrared and optical observations are analyzed using dynamical spectral and morphological coma models [123] to update and improve dust emission rates [4] and nucleus size estimates [5]. Using these results we show that 1) there is more than enough dust emitted from short period comets into bound solar system orbits to create and support the current interplanetary dust cloud (IPD); 2) that a population of dormant or extinct comets in the solar system is quite plausible; and 3) that the lifetime versus sublimation for the short period comets is much longer than their dynamical lifetime. [1] C.M. Lisse et al. (1998) Ap J 496 971. [2] C.M. Lisse et al. (1999) Icarus 140 189. [3] Y.R. Fernandez et al. (2000) Icarus 147 145 [4] L. Kresak and M. Kresakova (1987) in Symposium on Diversity and Similarity of Comets ESA SP-278 739 [5] D.C.Jewitt (1991) in Comets in the Post-Halley Era (R.L. Newburn M. Neugebauer and J. Rahe Eds.) Kluwer Academic Dordecht 19.

Mechanism of internal fertilization in Pegea socia (Tunicata, Thaliacea), a salp with a solid oviduct.

Science.gov (United States)

Holland, L Z; Miller, R L

1994-03-01

The ovary of the salp Pegea socia (Bosc, 1802) is located at the end of an atrial diverticulum. The ovary consists of a single oocyte encased in a layer of follicle cells and is connected to the atrial epithelium by an oviduct. Transmission electron microscopy shows that the oocyte lacks a vitelline layer, cortical granules, and yolk granules and that the oviduct lacks a continuous lumen. What previous authors thought was a lumen is a line of dense intercellular junctions running down the center of the oviduct. The sperm nucleus in this species, as in other salps, is elongate. The tubular mitochondrion spirals about the sperm nucleus giving it a corkscrew-shape appearance. Sperm reach the ovary when the oocyte is still at the germinal vesicle stage. Many sperm swim up the atrial diverticulum and burrow through the cells of the atrial epithelium, oviduct, and follicular epithelium. Thus oviduct shortening, which occurs when the oocyte is in the meiotic divisions, is evidently unrelated to sperm moving up the oviduct. All previous authors, who argued either that a continuous lumen is necessary for sperm to move up the oviduct or that sperm bypass the oviduct, were incorrect. © 1994 Wiley-Liss, Inc. Copyright © 1994 Wiley-Liss, Inc.

The influence of relative age on success and dropout in male soccer players.

Science.gov (United States)

Helsen, Werner F; Starkes, Janet L; Van Winckel, Jan

1998-01-01

The consistent asymmetry in the birth-date distribution of senior professional soccer players has led us to investigate whether similar asymmetries emerge throughout youth categories in soccer. Birth dates were considered for professional players, national youth teams, youth players transferred to top teams, and regular youth league players. Kolmogorov Smirnov tests assessed differences between observed and expected birth-date distributions. Regression analyses examined the relationship between month of birth and number of participants at various levels of play in soccer. Results indicated that youth players born from August to October (the early part of the selection year), beginning in the 6-8 year age group, are more likely to be identified as talented and to be exposed to higher levels of coaching. Eventually, these players are more likely to be transferred to top teams, to play for national teams, and to become involved professionally. In comparison, players born late in the selection year tended to dropout as early as 12 years of age. Recommendations suggest a review of the 24-month age band and current methods for talent detection and selection. Am. J. Hum. Biol. 10:791-798, 1998. © 1998 Wiley-Liss, Inc. Copyright © 1998 Wiley-Liss, Inc.

Characterizing the X-ray & Stellar Wind Environment in the ~1 Gyr Late Heavy Bombardment System Eta Corvi

Science.gov (United States)

Lisse, Carey

2012-09-01

We propose a 40 ksec ACIS-S observation of the 1 Gyr old system Eta Corvi, the site of an on-going Late Heavy Bombardment (Lisse et al. 2012), in order to determine the spectrum of x-ray radiation in the burgeoning system, its origin in the stellar coronae and circumstellar debris belts, and its impact on the water and organics recently delivered to a rocky planet in the terrestrial habitability zone.

EFFECT OF ROUGHNESS TO HYDRAULIC PROJECTION IN AN U ...

African Journals Online (AJOL)

30 juin 2011 ... 0,3. Fig.10. Variation de la longueur relative Lj/h1 du ressaut en fonction du débit relatif Q* pour quatre valeurs distinctes de y1. Les motifs colorés vides représentent les points expérimentaux du ressaut contrôlé en canal à fond rugueux. Les motifs vides noirs représentent le ressaut contrôléà fond lisse.

Barber-Say syndrome in a father and daughter.

Science.gov (United States)

Roche, Nathalie; Houtmeyers, Philippe; Janssens, Sandra; Blondeel, Philllip

2010-10-01

We report on a father to daughter transmission of Barber-Say syndrome (BSS), a rare, congenital disorder characterized by severe generalized hypertrichosis, macrostomia, ocular telecanthus, bulbous nose and atrophic skin. These two cases further support the autosomal dominant inheritance. Both presented with the typical BSS symptoms but the phenotypic expression in the father was milder. Treatment is challenging for both patients and doctors, requiring a multidisciplinary approach. Copyright © 2010 Wiley-Liss, Inc.

Use of the Boomerang catalyst advantage closure device to facilitate complex multistaged percutaneous revascularization procedures for the treatment of critical limb ischemia.

Science.gov (United States)

Garcia, Joel A; Casserly, Ivan P

2009-07-01

An increasing spectrum of complex peripheral arterial disease may be successfully treated using percutaneous revascularization techniques. A pair of challenging peripheral revascularization procedures in patients with critical limb ischemia is presented, where an array of interventional tools and techniques were required, and the off-label use of the Boomerang catalyst system closure device was important in managing a variety of complex arterial access issues and ultimately allowing procedural success. Copyright 2009 Wiley-Liss, Inc.

Prenatal diagnosis of boomerang dysplasia.

Science.gov (United States)

Wessels, Marja W; Den Hollander, Nicolette S; De Krijger, Ronald R; Bonifé, Luisa; Superti-Furga, Andrea; Nikkels, Peter G; Willems, Patrick J

2003-10-01

Boomerang dysplasia, atelosteogenesis type 1 and Piepkorn dysplasia are bone dysplasias with an overlapping clinical spectrum characterized by deficient formation and ossification of specific elements of the skeleton. Typical symptoms include micromelia with diminished ossification, and a characteristic bowed and boomerang-like aspect of the long tubular bones. We report here a new case of boomerang dysplasia, which was detected prenatally in the 16th week of gestation by ultrasound. Copyright 2003 Wiley-Liss, Inc.

Delphian node metastasis in head and neck cancers--oracle or myth?

Science.gov (United States)

Iyer, N Gopalakrishna; Shaha, Ashok R; Ferlito, Alfio; Thomas Robbins, K; Medina, Jesus E; Silver, Carl E; Rinaldo, Alessandra; Takes, Robert P; Suárez, Carlos; Rodrigo, Juan P; Bradley, Patrick J; Werner, Jochen A

2010-09-15

Delphian node (DN) refers to the pre-laryngeal or pre-cricoid nodal tissue often identified during laryngeal or thyroid surgery. The original nomenclature is based on the assumption that metastasis to this node was predictive of aggressive disease and poor outcome for patients. In this article, we review the existing literature on the topic to determine the significance of DN metastasis in laryngeal, hypopharyngeal and thyroid cancers. (c) 2010 Wiley-Liss, Inc.

Parental perspectives on living with a child with HoPE.

Science.gov (United States)

Stashinko, Elaine E; Harley, Leslie A; Steele, Roxanne A; Clegg, Nancy J

2010-02-15

This article describes the experiences and perceived needs of a small cohort of parents of children with holoprosencephaly (HPE). The factors that are important to the lives of children vary across families and stages of development. As children living with HPE grow and change, parents adapt their goals and expectations to reflect their child's now and future state. Relevant literature is integrated within the discussion to support recommendations for care. 2010 Wiley-Liss, Inc.

Modern Piracy and Regional Security Cooperation in the Maritime Domain: The Middle East and Southeast Asia

Science.gov (United States)

2010-03-01

Information Sharing Centre (ISC),” 433. 33 Catherine Zara Raymond, “Piracy and Armed Robbery in the Malacca Straits,” Naval War College Review 62:3...2009); Catherine Zara Raymond, “Piracy and Armed Robbery in the Malacca Straits,” Naval War College Review 62:3 (Summer 2009); Carolin Liss, “The...Charlottesville, Virginia: University Press of Virginia, 1988). Raymond, Catherine Zara . “Piracy and Armed Robbery in the Malacca Straits.” Naval War College

Case report

African Journals Online (AJOL)

ebutamanya

5 mai 2015 ... Abstract. Les tumeurs bénignes du muscle lisse sont fréquentes dans le tractus gastro-intestinal et génito-urinaire, et rares au niveau rétro péritonéal.Leur prévalence parmi les tumeurs rétropéritonéales primitives a été estimée entre de 0,5 à 1,2%. Une situation qui conduit à des erreurs de diagnostic.

Hepatic urea biosynthesis in the euryhaline elasmobranch Carcharhinus leucas.

Science.gov (United States)

Anderson, W Gary; Good, Jonathan P; Pillans, Richard D; Hazon, Neil; Franklin, Craig E

2005-10-01

Plasma urea levels and hepatic urea production in the euryhaline bull shark, Carcharhinus leucas, acclimated to freshwater and seawater environments were measured. It was found that plasma urea concentration increased with salinity and that this increase was, in part, the result of a significant increase in hepatic production of urea. This study provides direct evidence that hepatic production of urea plays an important role in the osmoregulatory strategy of C. leucas. (c) 2005 Wiley-Liss, Inc.

Incorporation of Novel MRI and Biomarkers into Prostate Cancer Active Surveillance Risk Assessment

Science.gov (United States)

2017-09-01

attending the MRI Ultrasound Fusion Guided Prostate biopsy II session at the American Urological Association 2017 annual meeting along with several...MV, Raman JD, Spears V, Stroup SP. An Update of the American Urological Association White Paper on the Prevention and Treatment of the More Common...support (no). Galván GC1, Johnson CB1, Price RS2, Liss MA3, Jolly CA1, deGraffenried LA1. Effects of Obesity on the Regulation of Macrophage

Mini-review: history of organized teratology information services in North America.

Science.gov (United States)

Leen-Mitchell, M; Martinez, L; Gallegos, S; Robertson, J; Carey, J C

2000-04-01

A history of the Organization of Teratology Information Services (OTIS) is presented in context of the history of teratology information services. During the late 1970s, teratology information services grew out of the need for current and accurate information about fetal effects of environmental exposures in pregnancy. Over the next decade, teratology information services networked and collaborated, developing their own professional organization. A description of the activities of OTIS is described. Copyright 2000 Wiley-Liss, Inc.

A hitchhiker's guide to the older literature of descriptive teratology.

Science.gov (United States)

Beckwith, J Bruce

2007-12-15

Though relatively neglected in the age of molecular biology, the older literature of teratology includes superb illustrations and descriptions of malformations, and other information of permanent value to science and medicine. Accessing that literature can be challenging, as most is in works that are rare, published in languages other than English, and not available in digital form. This article describes some valuable sources of information concerning the antiquarian literature of descriptive teratology. (c) 2007 Wiley-Liss, Inc.

A Spectral Survey of Six Comets in the Mid-Infrared.

Science.gov (United States)

Lisse, Carey M.; Sitko, M. L.; Reach, W. T.; Fernandez, Y. R.; Kelley, M. S.

2008-09-01

With the Spitzer Space Telescope (SST) and Infrared Space Observatory (ISO) we are beginning to understand the details of how the composition and formation of our own Solar System compares to those of other stars in our Galaxy. Recent, detailed observations of comets (remnants of the solar system's proto-stellar nebula), protoplanetary disks around young stellar objects (YSOs), and debris disks around moderate-age stars have given us a collection of detailed spectra containing clues about our Galactic context. Here we discuss 5 to 35 micron spectroscopy of the emission from dust grains and gas molecules in the comae of 6 recent comets: C/Hale-Bopp 1995 O1 [1], 29P/SW1 2004 [2], 9P/Tempel 1 2005 (ejecta) [3], 73P/SW3 (fragments B and C) [4], C/McNaught 2006 P1 [5], and 17P/Holmes 2007 [6]. We thank the Spitzer Science Center, the ISO project, and the NASA/IRTF for their support of this work. References: [1] Crovisier, J. et al. 1997, Science 275, 1904. [2] Stansberry, J.A. et al. 2004, ApJ Suppl. 154, 463. [3] Lisse, C.M. et al. 2006, Science 313, 635. [4] Sitko, M.L., et al. 2008, ACM 2008 abstract #8101. [5] Lisse, C.M. et al. 2007, IAUC 8862. [6] Reach, W.T. et al. 2009, in prep.

Physics near the strange and charm production thresholds

International Nuclear Information System (INIS)

Nagamiya, S.; Bland, L.C.

1995-01-01

LISS is a Light-Ion Spin Synchrotron and storage ring that is being considered as an upgrade of the Indiana University Cyclotron Facility. Current plans call for a racetrack design for the ring that will provide variable energy polarized proton and deuteron beams up to a momentum of 16 GeV/c and unpolarized light ions with 3 ≤A ≤ 40 accelerated to comparable rigidities. Experiments would be conducted using both polarized and unpolarized internal targets. The racetrack design for the ring will provide for two ∼100-m long, zero-dispersion straight sections that allow for the installation of sophisticated experimental equipment. The ring design will incorporate the recently developed technologies of Siberian snakes allowing for relatively straightforward acceleration and use of polarized beams for high-precision experiments, electron cooling for shrinking the emittance of the stored beams, and carrier-free polarized internal targets. This talk will focus on that part of the physics Program of the LISS facility associated with the production of strange and charmed quarks. Examples will include the study of the spin-dependence of the A-nucleon scattering length; second-generation associated hyperon production experiments emphasizing polarization transfer and exclusive identification of the produced hyperons (ΛΣ, etc.) with the goal of understanding the dynamical origin of hyperon polarization; and studies of the total charm production cross section in p-p collisions near threshold

Violent Adolescent Planet Caught Infrared Handed

Science.gov (United States)

Trang, D.; Gaidos, E.

2010-01-01

The prevailing view of planet formation depicts accumulation of progressively larger objects, culminating in accretionary impacts between Moon- to Mars-sized protoplanets. Cosmochemists have found evidence in chondritic meteorites for such violent events, and the Moon is thought to have involved a huge impact between a Mars-sized object and the still-growing proto-Earth. Now we may have evidence for a large impact during planet formation around another star. Carey Lisse (Applied Physics Lab of the Johns Hopkins University, Baltimore) and colleagues from the Space Telescope Science Institute (Baltimore), the University of Cambridge (UK), the Open University (Milton Keyes, UK), the University of Georgia (Athens, GA), Jet Propulsion Lab (Pasadena, CA), and the University of Rochester (New York) analyzed infrared spectra obtained by the Spitzer Space Telescope. They found a prominent peak in the spectrum at 9.3 micrometers, and two smaller ones at slightly lower and higher wavelengths. These peaks are consistent with the presence of SiO gas, a product expected to be produced by a highly energetic impact. The spectral measurements also allowed Lisse and his colleagues to estimate the size of the dust and they found that there is an abundance of micrometer-sized dust grains. This argues for a fresh source of fine material during the past 0.1 million years. That source may have been an impact between two protoplanets surrounding this young star.

The Human Variome Project (HVP) 2009 Forum "Towards Establishing Standards".

Science.gov (United States)

Howard, Heather J; Horaitis, Ourania; Cotton, Richard G H; Vihinen, Mauno; Dalgleish, Raymond; Robinson, Peter; Brookes, Anthony J; Axton, Myles; Hoffmann, Robert; Tuffery-Giraud, Sylvie

2010-03-01

The May 2009 Human Variome Project (HVP) Forum "Towards Establishing Standards" was a round table discussion attended by delegates from groups representing international efforts aimed at standardizing several aspects of the HVP: mutation nomenclature, description and annotation, clinical ontology, means to better characterize unclassified variants (UVs), and methods to capture mutations from diagnostic laboratories for broader distribution to the medical genetics research community. Methods for researchers to receive credit for their effort at mutation detection were also discussed. (c) 2010 Wiley-Liss, Inc.

2729-IJBCS-Article-Bechir Brahim

African Journals Online (AJOL)

hp

10(4): 1733-1746, 2016. 1738 zone d'étude ont montré un tronc le plus souvent lisse. Le diamètre à hauteur de poitrine (1,30 m) a varié de 16, 63 cm (à. Kokorguin) à 19,09 cm (à Arkou). La moyenne générale a été de 17,60 ± 0,07cm. (Tableau 3). Les individus de B. aegyptiaca ont une hauteur moyenne de 6,35 ± 1,27 m.

Further delineation of the odonto-onycho-dermal dysplasia syndrome.

Science.gov (United States)

Mégarbané, Hala; Haddad, May; Delague, Valérie; Renoux, Julien; Boehm, Nelly; Mégarbané, André

2004-08-30

We report on three boys, two brothers and their maternal cousin, presenting with dry hair, pilar keratosis, severe hypodontia, smooth tongue, onychodysplasia, and keratoderma and hyperhidrosis of palms and soles. Histology of the skin showed orthokeratotic, hyperkeratosis, hypergranulosis, and mild acanthosis in the epidermis. Scanning electron microscopic examination of the hair showed longitudinal depressions in some hair. These features are close to a rare entity: the odonto-onycho-dermal dysplasia but with some differing features. Copyright 2004 Wiley-Liss, Inc.

Influence of socioeconomic factors on survival after breast cancer-A nationwide cohort study of women diagnosed with breast cancer in Denmark 1983-1999

DEFF Research Database (Denmark)

Dalton, Susanne Oksbjerg; Ross, Lone; During, M.

2007-01-01

The reasons for social inequality in breast cancer survival are far from established. Our study aims to study the importance of a range of socioeconomic factors and comorbid disorders on survival after breast cancer surgery in Denmark where the health care system is tax-funded and uniform. All 25...... for the social inequality in survival after breast cancer surgery in Denmark lies in the access to and/or compliance with management of comorbid conditions in poorer women. (c) 2007 Wiley-Liss, Inc....

Variability in abundance and fluxes of dimethyl sulphide in the Indian Ocean

Digital Repository Service at National Institute of Oceanography (India)

Shenoy, D.M.; DileepKumar, M.

, 285-300 pp. Dacey, J.W.H. and S.G. Wakeham, 1986. Oceanic dimethyl sulfide: production during zooplankton grazing on phytoplankton. Science, 233, 1314-1316. Dickson, D.M., R.G. Wyn Jones and J. Davenport, 1980. Study-state osmotic adaptation.... Seasonal and short-term variability in dimethyl sulfide, sulfur dioxide and biogenic sulfur and sea salt aerosol particles in the arctic marine boundary layer during summer and autumn. Tellus, 48B, 272-299. Liss P.S., G. Malin and S.M. Turner, 1993...

Maternal alcohol drinking pattern during pregnancy and the risk for an offspring with an isolated congenital heart defect and in particular a ventricular septal defect or an atrial septal defect

DEFF Research Database (Denmark)

Strandberg-Larsen, Katrine; Skov-Ettrup, Lise Skrubbeltrang; Grønbaek, Morten

2011-01-01

(VSD) or of an atrial septal defect (ASD). METHODS: Participants were 80,346 pregnant women who were enrolled into the Danish National Birth Cohort in 1996-2002 and gave birth to a live-born singleton without any chromosome anomalies. Twice during pregnancy these women were asked about their intake...... the early part of pregnancy was not statistical significantly associated with the prevalence of isolated VSD and ASD in offspring. Birth Defects Research (Part A), 2011. © 2011 Wiley-Liss, Inc....

Pease AFB, Portsmouth, New Hampshire. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A through F.

Science.gov (United States)

1972-05-25

SNOW DEPTH IN INCHES lIAS*O ON Liss THAN PULL NONTHS1 MON I tJAN, FEB. MAN. APR. MAY JUN JUL. AUG. SEP. OCT. NOV. DC. ALL 5* ’SNO OPTH _ _ _~DAYS...J- 3 iL-i- A1 L L_ 4L -10 ’- .0 _m GoAlI ’SW .. L JL 44.. ak af AL aw 1* 4. l.0 4.2 6...4. s fl .40 1& .0 -0 -7. __ on ltil - -. C TWAL NUMM

Young siblings of children with cancer deserve care and a personalized approach.

Science.gov (United States)

Massimo, Luisa M; Wiley, Thomas J

2008-03-01

The youngest siblings may be both emotionally vulnerable and often neglected members of the family of a childhood cancer patient. The prompt identification of signs of distress in these subjects allows trained caregivers to intervene with personalized, age-appropriate, attention, and care. A narrative approach, based on personalized listening, writings, and spontaneous drawings, can provide the means to elicit markers of psychological maladjustment in even the youngest of siblings. Two exemplary cases are reported to illustrate this approach. (c) 2007 Wiley-Liss, Inc.

Effect of high energy electrons on the skin and on the underlying tissues of the rabbit. A clinical and histological study; Effets des electrons de haute energie sur la peau et les tissus sous-jacents du lapin. Etude clinique et histologique

Energy Technology Data Exchange (ETDEWEB)

Legeay, G; Vialettes, H; Adnet, J J; Court, L; Masse, R [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1967-07-01

The authors consider in this report the effects of high-energy electrons on rabbit teguments and on the underlying tissues after a single high dose irradiation. After briefly considering the mechanism of interaction between the electrons and matter as a function of their energy, the authors describe the dosimetry carried out, as a function of the irradiation device. The animal received surface doses of 5700 to 22100 rads in the thigh; the electron energy varied from 21 to 30 MeV. A clinical study was carried out over a period of nine months with a view to following the evolution of the damage and the functional degradation of the underlying tissues. A histological study of the induced damage was made after a second irradiation using 30 MeV electrons to produce doses of 16400 rads. Interesting observations were made concerning the damage caused to muscular and nerve tissues. (authors) [French] Les auteurs etudient, dans ce rapport, les effets des electrons de haute energie sur les teguments du lapin et les tissus sous-jacents apres une irradiation unique a dose elevee. Apres un rappel du mecanisme de l'interaction des electrons avec la matiere en fonction de leur energie, la dosimetrie realisee est exposee en fonction du dispositif d'irradiation. Les animaux ont recu, au niveau de la cuisse, des doses en surface de 5700 a 22100 rads; les energies des electrons vont de 21 a 30 MeV. Une etude clinique des lesions, observees pendant 9 mois, decrit leur evolution ainsi que les alterations fonctionnelles des tissus sous-jacents. Une etude histologique des lesions induites a ete realisee au cours d'une seconde experience pour des doses de 16400 rads avec des electrons de 30 MeV. D'interessantes observations ont ete faites concernant les lesions des tissus musculaires et nerveux. (auteurs)

Assessment of the Total Body Burden of Caesium-137 in Humans by the Analysis of Blood; Determination de la Charge Corporelle de Cesium 137 chez l'Homme, par Analyse Du Sang; 041e 041f 0420 0415 0414 ; Evaluacion de la Carga Corporal Total de Cesio-137 en el Hombre por Analisis de Sangre

Energy Technology Data Exchange (ETDEWEB)

Yamagata, N. [Institute of Public Health, Tokyo (Japan)

1964-11-15

Analysis of post-mortem samples for caesium-137 has been carried on in Japan because whole-body counters are limited in number and not mobile, making the assessment of the population mean levels inconvenient. However, the collection of muscles from autopsies throughout the country is complicated and inconvenient in that a sample should be taken immediately after death. Considering that only such data as are useful for the assessment of the mean levels of caesium-137 in people are required and it is unnecessary to know individual values, the composite samples of as many individuals as possible would be enough for the analysis. For this purpose, whole blood samples were considered as the best substitute for muscles, as the blood collection system covers the whole country, including 47 licensed blood banks and about 100 hospitals. Sampling inspection is made continuously of citrated whole blood at the National Institute of Health, Tokyo, where about 500 ampoules are checked, representing more than three million donors throughout the country per year. Less than half the blood in an ampoule was consumed for inspection and the remaining half was stocked to make a composite for the determination of caesium-137 level. Blood ashes were analysed for the stable caesium content by a neutron activation method. The results afforded the relation between the concentration in the whole blood and the total body amount (1.4 mg for 70 kg man) and this relation would be identical to that for caesium-137 in an equilibrium condition. The results of blood analysis for caesium-137 obtained since June 1963 were compared with those of muscle analyses made during the same period. Good agreement was observed and the blood analysis was found to be the best means for assessing the total body burden of caesium-137 in a population. (author) [French] Au Japon, on a dose le cesium 137 d'echantillons de tissus musculaires preleves au cours d'autopsies, car il n'y a qu'un petit nombre d

{gamma}-irradiation-induced oxidative stress and aging of cultured endothelial cells; Stress oxydant et vieillissement vasculaire in vitro etude apres irradiation {gamma} de cellules endotheliales

Energy Technology Data Exchange (ETDEWEB)

Van Uye, A.; Agay, D.; Drouet, M.; Chancerelle, Y.; Mathieu, J.; Kergonou, J.F.; Mestries, J.C.

1995-12-31

The aim of this work was to study aging of cultured vascular cells. In order to induce an oxidative stress, which is known to participate in aging process, we apply {gamma}-induced peroxidation and is revealed by indirect immunofluorescence. (author). 6 refs.

Fertilite Et Compatibilite De Six Varietes D\\'ananas ( Ananas ...

African Journals Online (AJOL)

Les variétés d\\'ananas cultivées en Côte d\\'Ivoire dont H10 et H25 appartiennent au groupe Cayenne lisse qui constitue un groupe d\\'incompatibilité. Le programme d\\'amélioration génétique de l\\'ananas initié dès 1978 a permis de créer de nombreux hybrides parmi lesquels H15, H33 et P34 ont été sélectionnés. L\\'étude ...

Fine-needle aspiration cytology of mucous retention cyst of the tongue: distinction from other cystic lesions of the tongue.

Science.gov (United States)

De Las Casas, L E; Bardales, R H

2000-05-01

Mucous retention cyst (MRC) is a common submucosal lesion of the oral cavity that, when deeply seated, simulates a neoplasm. This report describes the fine-needle aspiration cytology findings of a lingual MRC of complex architecture and with metaplastic epithelium. In addition, we emphasize its cytologic differential diagnosis from other benign and malignant cystic lesions of the tongue. To the best of our knowledge, this is the first report of aspiration cytology of a complex MRC of the tongue. Copyright 2000 Wiley-Liss, Inc.

Fetal bilateral renal agenesis, phocomelia, and single umbilical artery associated with cocaine abuse in early pregnancy.

Science.gov (United States)

Kashiwagi, Maki; Chaoui, Rabih; Stallmach, Thomas; Hürlimann, Sandra; Lauper, Urs; Hebisch, Gundula

2003-11-01

Maternal cocaine abuse in pregnancy is associated with complications such as intrauterine growth retardation, abruptio placentae, and preterm delivery. We report what is, to our knowledge, the first published observation of fetal bilateral renal agenesis associated with a vascular disruption syndrome comprising upper limb reduction defect and a single umbilical artery following maternal cocaine abuse in early pregnancy. This constellation in a fetus aborted at 18 weeks extends the spectrum of complications possibly associated with cocaine abuse in pregnancy. Copyright 2003 Wiley-Liss, Inc.

Morphology selection for cupric oxide thin films by electrodeposition.

Science.gov (United States)

Dhanasekaran, V; Mahalingam, T; Chandramohan, R

2011-10-01

Polycrystalline cupric oxide thin films were deposited using alkaline solution bath employing cathodic electrodeposition method. The thin films were electrodeposited at various solution pH. The surface morphology and elemental analyzes of the films were studied using scanning electron microscopy (SEM) and energy dispersive X-ray analysis, respectively. SEM studies revealed that the surface morphology could be tailored suitably by adjusting the pH value during deposition. Mesh average on multiple lattice mode atomic force microscopy image was obtained and reported. Copyright © 2011 Wiley-Liss, Inc.

Bibliografía

OpenAIRE

2015-01-01

Abram, Matthias1992. Lengua, cultura e identidad. El proyecto EBl 1985-1990. Quito: Proyecto EBI/Abya Yala. Academia Mayor de la Lengua Quechua1995 Diccionario Quechua-Español-Quechua. Qheswa-Español-Qheswa Simi Taqe. Cuzco: Municipalidad del Cuzco. Adelaar, Willem1977. Tarma Quechua. Grammar, Texts, Dictionary. Lisse: Peter de Ridder Press.1986 “La relación quechua-aru: perspectivas para la separación del léxico”. Revista Andina 4 (2): 379426.1999. “Unprotected Languages: The Silent Death of...

Nephrogenic systemic fibrosis versus contrast-induced nephropathy: risks and benefits of contrast-enhanced MR and CT in renally impaired patients

DEFF Research Database (Denmark)

Martin, Diego R; Semelka, Richard C; Chapman, Arlene

2009-01-01

-sectional imaging modality. Factors to consider include the relative risks of the contrast agent. Other factors include the relative procedural risks, including radiation risks and the relative expected diagnostic yield of the examination technique (12). In this review we describe both nephrogenic systemic fibrosis...... and contrast-induced nephropathy to compare the implications with regard to relative risks and benefits of contrast-enhanced MRI or CT in patients with impaired renal function. J. Magn. Reson. Imaging 2009;30:1350-1356. (c) 2009 Wiley-Liss, Inc....

Henry Gray's Anatomy.

Science.gov (United States)

Pearce, J M S

2009-04-01

Little is generally known of Henry Gray, the author of Gray's Anatomy, and even less of his colleague Henry Vandyke Carter, who played a vital role in the dissections and illustrations leading to the production of the first volume in 1859. This essay attempts to sketch briefly the salient, know aspects of these two men and their divergent careers. It traces succinctly the subsequent fate of the unique anatomy book that has influenced and instructed almost every student of medicine. (c) 2009 Wiley-Liss, Inc.

Land use and water quality degradation in the Peixe-Boi River watershed

OpenAIRE

Bruno Wendell de Freitas Pereira; Maria de Nazaré Martins Maciel; Francisco de Assis Oliveira; Marcelo Augusto Moreno da Silva Alves; Adriana Melo Ribeiro; ; Bruno Monteiro Ferreira; Ellen Gabriele Pinto Ribeiro

2016-01-01

This study mapped the land use and land cover of the catchment area of the Peixe-Boi River watershed, in northeast Pará, in order to identify conflicts of land use in the permanent preservation areas, and to relate them to water quality. We used LISS-3 sensor imagery from the Resourcesat satellite with a spatial resolution of 23.5 m for supervised classification of land use and land cover based on 22 training samples. Water quality was determined based on 28 sampling points in drainage networ...

Contribution of tropical cyclones to the air-sea CO2 flux: A global view

Digital Repository Service at National Institute of Oceanography (India)

Levy, M.; Lengaigne, M.; Bopp, L.; Vincent, E.M.; Madec, G.; Ethe, C.; DileepKumar, M.; Sarma, V.V.S.S.

.ocemod.2006.11.003.501 D’Asaro, E. (2003), The ocean boundary layer below hurricane dennis, Journal of physical502 oceanography, 33(3), 561–579.503 D’Asaro,E.,andC.McNeil(2007),Air-seagasexchangeatextremewindspeedsmeasured504 by autonomous oceanographic floats... at high wind speed [Liss and Merlivat, 1986; Wanninkhof, 1992; D’Asaro and McNeil,55 2007; McNeil and D’Asaro, 2007]. TCs also impact F CO 2 because their intense surface56 winds increase vertical entrainment of subsurface waters (hereafter referred...

Proceedings of the AMEDD Clinical Psychology Short Course (1987): Military Applications of Neuropsychology and Health Psychology Held in San Francisco, California on 9-13 March 1987. Volume 2.

Science.gov (United States)

1987-07-01

If. I. Kaplan , & B. J. Sadock (Eds), Comprehensive textbook ofpsychiatry (Vol. 2, 2nd ed ). Baltimore, Md.: Williams & Wilkins, 1975. Lipowski, Z. J...ratat ion was t hef vr t aormod. arcma~r>.a -Xtr lct-d whicn acca "Inted f ai b3 -a t.vranc- a" ’fa is t (:a01.’aa0 -a nt v",’,Sc Ca:11) isa a:, ta n...Professional Psychology: Research and Practice, 17, 514-518. -- __ Hare-Must in, R. T., Marecek, J., Kaplan , G., & Liss-Levinson, N. (1979). Rights of

Chandra Studies of Planets and Comets in the X-ray

Science.gov (United States)

Lisse, Carey; Bhardwaj, A.; Wolk, S. J.; Christian, D. J.; Dennerl, K.; Bodewits, D.; Zurbuchen, T. H.

2009-09-01

The discovery of high energy x-ray emission in 1996 from C/1996 B2 (Hyakutake) created a new class of solar system x-ray emitting objects [1]. Subsequent detections of the morphology, spectra, and time dependence of the x-rays from more than 20 comets have shown that the very soft (E Lisse et al., Science 274, 205 (1996)[2] R. Wegmann and K. Dennerl, A&A 430, L33 (2005)[3] D. Bodewits et al., A&A 469, 1183 (2007)[4] A. Bhardwaj et al., PSS 55, 1135 - 1189 (2007)

Example of the Smooth Skew Product in the Plane with the One-dimensional Ramified Continuum as the Global Attractor*

Directory of Open Access Journals (Sweden)

Efremova L.S.

2012-08-01

Full Text Available The example is constructed of the C1-smooth skew product of interval maps possessing the one-dimensional ramified continuum (containing no arcs homeomorphic to the circle with an infinite set of ramification points as the global attractor. L’exemple est construit à partir d’un produit biaisé lisse de classe C1 de transformations d’un intervalle, qui a un continuum unidimensionnel ramifié (ne contenant pas d’arcs homéomorphes à un cercle avec un ensemble infini de points de branchement comme attracteur global.

Time-lapse imaging of neural development: zebrafish lead the way into the fourth dimension.

Science.gov (United States)

Rieger, Sandra; Wang, Fang; Sagasti, Alvaro

2011-07-01

Time-lapse imaging is often the only way to appreciate fully the many dynamic cell movements critical to neural development. Zebrafish possess many advantages that make them the best vertebrate model organism for live imaging of dynamic development events. This review will discuss technical considerations of time-lapse imaging experiments in zebrafish, describe selected examples of imaging studies in zebrafish that revealed new features or principles of neural development, and consider the promise and challenges of future time-lapse studies of neural development in zebrafish embryos and adults. Copyright © 2011 Wiley-Liss, Inc.

Coffin-Siris syndrome: review and presentation of new cases from a questionnaire study.

Science.gov (United States)

Fleck, B J; Pandya, A; Vanner, L; Kerkering, K; Bodurtha, J

2001-02-15

To clarify the phenotypic variability of Coffin-Siris syndrome, we present a review of the literature and 18 new cases. We performed a questionnaire study of patients ascertained through an international support group. Information on their sibs was available for comparison. The most frequent findings include some degree of mental retardation or developmental delay, "coarse" facial appearance, feeding difficulties, frequent infections, and hypoplastic to absent fifth fingernails and fifth distal phalanges. We discuss the key manifestations for diagnosis, medical and developmental implications, and possible pathogenesis. Copyright Wiley-Liss. Inc.

The integration of Darwinism and evolutionary morphology: Alexej Nikolajevich Sewertzoff (1866-1936) and the developmental basis of evolutionary change.

Science.gov (United States)

Levit, George S; Hossfeld, Uwe; Olsson, Lennart

2004-07-15

The growth of evolutionary morphology in the late 19th and early 20th centuries was inspired by the work of Carl Gegenbaur (1826-1903) and his protégé and friend Ernst Haeckel (1834-1919). However, neither of them succeeded in creating and applying a strictly Darwinian (selectionist) methodology. This task was left to the next generation of evolutionary morphologists. In this paper we present a relatively unknown researcher, Alexej Nikolajevich Sewertzoff (1866-1936) who made important contributions towards a synthesis of Darwinism and evolutionary morphology. Copyright 2004 Wiley-Liss, Inc.

Bacterial growth efficiency in the tropical estuarine and coastal waters of Goa, southwest coast of India

Digital Repository Service at National Institute of Oceanography (India)

Ram, A.; Nair, S.; Chandramohan, D.

overview. Mar Ecol Prog Ser 43:1-10 8. Del Giorgio PA, Cole 11 (1998) Bacterial growth efficiency in natural aquatic ecosystems. Annu Rev Ecol Syst 29:503 541 9. Del Giorgio PA, Cole n (2000) Bacterial energetics and growth efficiency. In: DL Kirchman (ed...) Microbial Ecology of the Oceans. Wiley-Liss, New York pp289~325 10. Del Giorgio PA, Gasol JM, Mura P, Vaque D, Duarte CM (1996) Protozoan control of the proportion of metabolically active bacteria in coastal marine plankton. Limnol Oceanogr 41:1169-1179 11...

Diastereoselectivity in scalemic tartrate/titanium epoxidations.

Science.gov (United States)

Brown, J M; Leppard, S J; Oakes, J; Thornthwaite, D

2000-06-01

Nonlinearity in the diastereoselectivity of epoxidation of allylic alcohols with mixtures of titanium isopropoxide, tertbutyl hydroperoxide, and diethyl tartrate was observed. Racemic and enantiomerically pure alcohols E-2-methyl-4-hexen-3-ol and E-1-methoxy-5-(O-tertbutyldimethylsilyloxy)-2-penten-4-ol were prepared. Epoxidation reactions were carried out with Ti(OPri)4 and ButOOH accompanied by diethyl tartrate of varying enantiomeric purity. The simplest explanation of these results is that a dimeric epoxidation reagent is involved, with significantly different reactivity for the homochiral and racemic forms. Copyright 2000 Wiley-Liss, Inc.

Interspecific variation of ontogeny and skull shape among porpoises (Phocoenidae)

DEFF Research Database (Denmark)

Galatius-Jørgensen, Anders; Berta, Annalisa; Frandsen, Marie Michele Schou

2011-01-01

. dioptrica, for which large series were available, were further compared in terms of ontogeny of cranial shape by three-dimensional geometric morphometrics. Ph. dalli and P. dioptrica generally showed further development of cranial sutures than the other species. Postnatal skull shape development was similar...... was detected; in species with pelagic preference the position and orientation of the foramen magnum aligned the skull with the vertebral column; the rostrum showed less ventral inclination, and the facial region was larger and more concave in lateral aspect. J. Morphol., 2011. © 2010 Wiley-Liss, Inc....

Heterozygous M1V variant of ELA-2 gene mutation associated with G-CSF refractory severe congenital neutropenia.

Science.gov (United States)

Setty, Bhuvana A; Yeager, Nicholas D; Bajwa, Rajinder P

2011-09-01

Severe congenital neutropenia is an autosomal recessive disorder characterized by maturation arrest at the promyelocyte/myelocyte phase in the bone marrow, absolute neutrophil count ELA-2 have been described. We report the case of a premature male infant with congenital neutropenia, associated with multiple infections, refractory to treatment with granulocyte colony stimulating factor who subsequently underwent matched sibling donor stem-cell transplant. He was found to be heterozygous for the M1V variant of the ELA-2 gene that we postulate to be causative for his severe neutropenia Copyright © 2011 Wiley-Liss, Inc.

Lignes directrices sur la prise en charge en soins primaires des céphalées chez l’adulte

Science.gov (United States)

Becker, Werner J.; Findlay, Ted; Moga, Carmen; Scott, N. Ann; Harstall, Christa; Taenzer, Paul

2015-01-01

Résumé Objectif Accroître l’utilisation d’approches éclairées par des données probantes pour diagnostiquer, investiguer et traiter en soins primaires les céphalées des patients. Qualité des données Une recherche documentaire exhaustive a été effectuée pour trouver des lignes directrices et des révisions systématiques publiées entre janvier 2000 et mai 2011. La grille d’évaluation de la qualité des recommandations pour la pratique clinique AGREE a servi à l’analyse critique des lignes directrices. Les 6 guides de pratique clinique de la plus grande qualité ont servi de base dans le processus d’adaptation. Message principal Un groupe d’élaboration multidisciplinaire de professionnels des soins primaires ont formulé 91 recommandations précises à l’aide d’un processus consensuel. Les recommandations portent sur le diagnostic, l’investigation et la prise en charge de la migraine, de la céphalée de tension, de la céphalée due à une surmédication et de la céphalée vasculaire de Horton. Conclusion Un guide de pratique clinique adapté au contexte des soins de santé au Canada a été produit en suivant un processus d’adaptation de lignes directrices dans le but d’aider les professionnels de toutes les disciplines des soins primaires à dispenser des soins éclairés par des données probantes aux patients souffrant de céphalées.

The office based CHIVA

Directory of Open Access Journals (Sweden)

Passariello F

2013-09-01

Full Text Available Fausto Passariello,1 Stefano Ermini,2 Massimo Cappelli,3 Roberto Delfrate,4 Claude Franceschi5 1Centro Diagnostico Aquarius, Napoli, Italy; 2Private Practice, Grassina, Italy; 3Private Practice, Firenze, Italy; 4Casa di Cure Figlie di Maria, Cremona, Italy; 5Hospital St Joseph, Service d'Explorations Vasculaires, Paris, France Abstract: The cure Conservatrice Hémodynamique de l'Insuffisance Veineuse en Ambulatoire (CHIVA can be office based (OB. The OB-CHIVA protocol is aimed at transferring CHIVA procedures to specialists rooms. The protocol will check the feasibility of OB-CHIVA, data pertaining to recurrence, and will offer the opportunity to study saphenous femoral junction (SFJ stump evolution, the role of the washing vessels and the arch recanalization rate, and gather new data about the effect of the length of the treated saphenous vein. A simplified diagnostic procedure will allow an essential ultrasound examination of the venous net while a schematic and easily readable algorithm guides therapeutic choices. The Riobamba draining crossotomy (RDC tactic is composed of a set of OB procedures. While some of these procedures are, at the moment, only proposals, others are already applied. Devices generally used in ablative procedures such as Light Amplification by Stimulated Emission of Radiation (LASER, radio frequency, steam, and mechanical devices are used in this context to serve to conservative interventions for CHIVA. New techniques have also been proposed for devalvulation and tributary disconnection. Detailed follow-up is necessary in order to determine the effects of therapy and possible disease evolution. Finally, information is added about the informed consent and the ethical considerations of OB-CHIVA research. Keywords: CHIVA, office based procedures, LASER, RF, steam

Le collagène XXII, composant de la jonction myotendineuse, est un nouveau gène candidat dans les dystrophies musculaires : étude fonctionnelle chez le poisson zèbre

OpenAIRE

Charvet , Benjamin

2011-01-01

The myotendinous junction (MTJ) is a specialized structure that transmits muscle contractile forces to tendon. Collagen XXII (COLXXII) is a novel component of MTJ (Koch et al., 2004). It belongs to the FACITs (Fibrils Associated Collagen with Interrupted Triple helix) subset of the collagen superfamily that is characterized by their capacity to mediate protein-protein interactions. The in vivo role of COLXXII has not been elucidated. Therefore, we decided to analyze its function in developing...

Prevalence of anal cytological abnormalities in women with positive cervical cytology.

Science.gov (United States)

Calore, Edenilson E; Giaccio, Claudia Maria Serafim; Nadal, Sidney R

2011-05-01

The objective of this study was to estimate the prevalence of cytological abnormalities of the anal mucosa in women with positive cervical cytology, but without macroscopic anal lesion. Ultimately we postulated if the anal mucosa may be a reservoir of HPV, which would allow the reinfection of cervix. Forty-nine patients with abnormal cervical cytology were selected for this work. In a period not exceeding one week of collecting cervix cytology, two swab specimens of the anal canal were also collected. Women diagnosed with cervical HSIL by Pap smear were referred for colposcopy with biopsy of the lesions, to confirm the cytologic diagnosis and ablation of the lesion. We demonstrated a high prevalence of anal squamous intraepithelial lesions in patients with cervical squamous intraepithelial lesions (29 of the total of 49 patients = 59.2%). Of the 20 cases of cervical LSIL, 11 (55%) had abnormal anal cytology. Of the 26 cases with cervical HSIL, 16 (61.5%) had abnormal anal cytology. So, there was a discrete higher prevalence of abnormal anal cytology in cases of high-grade cervical squamous lesions (cervical HSIL). These results help to support the hypothesis that the anal mucosa is a reservoir of HPV, which can be a source of re-infection for the cervix. However, there was no significant association between the practice of anal sex and the prevalence of anal cytological abnormalities. These facts are epidemiologically important for future programs for population eradication of cervical lesions related to HPV. Diagn. Cytopathol. 2011;39:323-327. © 2010 Wiley-Liss, Inc. Copyright © 2010 Wiley-Liss, Inc.

Ejaculate of sneaker males is pheromonally inconspicuous in the black goby, Gobius niger (Teleostei, Gobiidae).

Science.gov (United States)

Locatello, L; Mazzoldi, C; Rasotto, M B

2002-11-01

The black goby, Gobius niger, shows alternative male mating tactics, i.e., parental and sneaker males. Males release a sexual pheromone that attracts females and stimulates aggressive displays in males. This pheromone is produced by the mesorchial gland, a structure well developed in parental males but markedly undeveloped in sneakers. We measured the behavioral response of parental males to the ejaculates of males performing different reproductive tactics. Parental males reacted to the ejaculate of other parental males, with stereotypic aggressive behaviors, but not to the ejaculate of sneakers; consequently sneaker male ejaculate appears to be pheromonally inconspicuous. Copyright 2002 Wiley-Liss, Inc.

A Spitzer IRS Study of Comets 71P/Clark and C/2004 B1 (LINEAR): Water, Carbonates, PAHs

Science.gov (United States)

Woodward, Charles E.; Bockelee-Morvan, D.; Kelley, M. S.; Wooden, D. H.

2009-01-01

Production rates of volatiles are used to quantify cometary activity and to measure volatile abundances. Water is the dominant ice in cometary nuclei and its sublimation governs the activity of comets at heliocentric distances, Lisse et al. 2007, Icarus 187, 69 as reviewed by Crovisier and Bockelee-Morvan 2008, Icarus 195, 938) for comets 9P/Tempel 1 and C/1995 O1 (Hale-Bopp). Support for this work provided in part by NASA through contracts 1263741, 1256406, and 1215746 issued by JPL/Caltech to the University of Minnesota, and the National Science Foundation grant AST-0706980.

XMM observations of Pluto

Science.gov (United States)

Lisse, C.; McNutt, R.; Dennerl, K.

2017-10-01

We have used XMM to observe the Pluto system in late March 2017. Following up on the reported detection of 7 photons representing X-ray emission by Chandra (Lisse et al., Icarus 287, 103), XMM searched for emission from the system, expecting approximately 10 times as many photons in 1/3 the observing time. If the results of the XMM measurements are as expected, then detections of other large KBOs with lossy atmospheres should be possible, ushering in the era of XMM KBO X-ray astronomy. In this talk we describe the preliminary results of our March 2017 XMM Pluto observations.

Relationships between individualism-collectivism, gender, and direct or indirect aggression: a study in China, Poland, and the US.

Science.gov (United States)

Forbes, Gordon; Zhang, Xiaoying; Doroszewicz, Krystyna; Haas, Kelly

2009-01-01

Direct and indirect aggression were studied in college students from China (women n=122; men n=97), a highly collectivistic culture; the US (women n=137; men n=136), a highly individualistic culture; and Poland (women n=105; men n=119), a culture with intermediate levels of collectivism and individualism. Consistent with a hypothesis derived from national differences in relative levels of collectivism and individualism, both direct and indirect aggression were higher in the US than in Poland and higher in Poland than in China. The theoretical implication of these results and directions for future research were discussed. Copyright 2008 Wiley-Liss, Inc.

From fins to limbs to fins: limb evolution in fossil marine reptiles.

Science.gov (United States)

Caldwell, Michael W

2002-10-15

Limb osteology and ontogenetic patterns of limb ossification are reviewed for extinct lineages of aquatically adapted diapsid reptiles. Phylogenies including these fossil taxa show that paddle-like limbs were independently derived, and that the varied limb morphologies were produced by evolutionary modifications to different aspects of the limb skeleton. Ancient marine reptiles modify the limb by reducing the relative size of the epipodials, modifying the perichondral and periosteal surface of elements distal to the propodials, and evolving extremes of hyperphalangy and hyperdactyly. Developmental genetic models illuminate gene systems that may have controlled limb evolution in these animals. Copyright 2002 Wiley-Liss, Inc.

Osaamisen kehittämisen haasteet, esteet ja kannusteet työuran keskivaiheen muutostilanteissa

OpenAIRE

Törmälä-Rantala, Päivi

2017-01-01

Työn tavoitteena oli tutkia osaamisen kehittämisen haasteita, esteitä ja kannusteita työuran puolivälissä. Tutkimuksessa selvitettiin, miksi toinen opiskelee ja koulutuksen avulla muuttaa työtilannettaan aktiivisesti, kun taas toinen jättää osaamisensa kehittämisen ja jämähtää samaan työtehtävään vuosiksi. Kartoitus toimi taustatietona Työterveyslaitoksen Taidot työhön –hankkeeseen. Hanke toteutettiin interventiona, ja siinä opastettiin ja kannustettiin ihmisiä parantamaan työllistymiskykyään...

Noninvasive ventilatory strategies in the management of a newborn infant and three children with congenital central hypoventilation syndrome.

Science.gov (United States)

Tibballs, James; Henning, Robert D

2003-12-01

Four children with congenital central hypoventilation syndrome (CCHS) treated with noninvasive techniques of ventilation are presented. Two infants (one in the newborn period) were treated with nasal mask bilevel positive airway pressure (BiPAP), and then both were transitioned to negative pressure chamber ventilation at several years of age because of possible midface hypoplasia. Tracheostomies were not performed. Two older children were transitioned from mechanical ventilation via tracheostomy to nasal mask BiPAP, and then in one case to negative pressure chamber ventilation, and in the other to phrenic nerve pacing. Their tracheostomies were removed. Copyright 2003 Wiley-Liss, Inc.

Error reduction and parameter optimization of the TAPIR method for fast T1 mapping.

Science.gov (United States)

Zaitsev, M; Steinhoff, S; Shah, N J

2003-06-01

A methodology is presented for the reduction of both systematic and random errors in T(1) determination using TAPIR, a Look-Locker-based fast T(1) mapping technique. The relations between various sequence parameters were carefully investigated in order to develop recipes for choosing optimal sequence parameters. Theoretical predictions for the optimal flip angle were verified experimentally. Inversion pulse imperfections were identified as the main source of systematic errors in T(1) determination with TAPIR. An effective remedy is demonstrated which includes extension of the measurement protocol to include a special sequence for mapping the inversion efficiency itself. Copyright 2003 Wiley-Liss, Inc.

Fingerprint-based structure retrieval using electron density.

Science.gov (United States)

Yin, Shuangye; Dokholyan, Nikolay V

2011-03-01

We present a computational approach that can quickly search a large protein structural database to identify structures that fit a given electron density, such as determined by cryo-electron microscopy. We use geometric invariants (fingerprints) constructed using 3D Zernike moments to describe the electron density, and reduce the problem of fitting of the structure to the electron density to simple fingerprint comparison. Using this approach, we are able to screen the entire Protein Data Bank and identify structures that fit two experimental electron densities determined by cryo-electron microscopy. Copyright © 2010 Wiley-Liss, Inc.

5-HT 1A polymorphism and self-transcendence in mood disorders.

Science.gov (United States)

Lorenzi, Cristina; Serretti, Alessandro; Mandelli, Laura; Tubazio, Viviana; Ploia, Cristina; Smeraldi, Enrico

2005-08-05

Recently, an association between serotonin 1A receptor binding potential and self-transcendence scores at the temperament and character inventory (TCI) has been reported. We tested involvement of 5-HT(1A) gene in this trait, in a sample of 40 remitted mood disorder patients. Subjects with the 5-HT(1A)*C/C genotype showed significantly lower scores at the total self-transcendence and at the sub-scales of transpersonal identification and spiritual acceptance. Our preliminary results further support the involvement of the serotoninergic pattern in the self-transcendence character trait. (c) 2005 Wiley-Liss, Inc.

Novel syndrome of cataracts, retinitis pigmentosa, late onset deafness and sperm abnormalities: a new Usher syndrome subtype with X-linked inheritance?

Science.gov (United States)

Malekpour, Mahdi; Shahidi, Arash; Khorsandi Ashtiani, Mohammad Taghi; Motasaddi Zarandy, Masoud

2007-07-15

Tissues of the auditory, ocular and reproductive systems have some similarities in their protein families and structures. Consequently, syndromes comprising these systems are described. Hearing loss alone is a component of more than 400 known syndromes and is a common nonsyndromic congenital disorder. Here we describe a syndrome in five brothers with the distinctive presentation of late-onset progressive hearing loss, cataracts, retinitis pigmentosa, sperm motility and shape problems in a family from the Kurdish population in Iran. The clinical findings of these patients are presented in detail and compared to the classical Usher syndromes. (c) 2007 Wiley-Liss, Inc

Mutations in the G6PC3 gene cause Dursun syndrome.

Science.gov (United States)

Banka, Siddharth; Newman, William G; Ozgül, R Koksal; Dursun, Ali

2010-10-01

Dursun syndrome is a triad of familial primary pulmonary hypertension, leucopenia, and atrial septal defect. Here we demonstrate that mutations in G6PC3 cause Dursun syndrome. Mutations in G6PC3 are known to also cause severe congenital neutropenia type 4. Identification of the genetic basis of Dursun syndrome expands the pre-existing knowledge about the phenotypic effects of mutations in G6PC3. We propose that Dursun syndrome should now be considered as a subset of severe congenital neutropenia type 4 with pulmonary hypertension as an important clinical feature. Copyright © 2010 Wiley-Liss, Inc.

Intermittent chronic neutropenia in a patient with familial Mediterranean fever.

Science.gov (United States)

Ganiou Tidjani, K; Ailal, F; Najib, J; Bellanné-Chantelot, C; Donadieu, J; Bousfiha, A A

2008-11-01

A 12-year-old daughter of consanguineous Moroccan parents was diagnosed with cyclic neutropenia, based on a combination of recurrent gingivostomatitis, a fluctuating neutrophil count, and several episodes of severe neutropenia. No ELA2 gene mutations were found. At age 19 years she presented with edema of the limbs, proteinuria and renal failure. Renal amyloidosis AA was diagnosed by biopsy. Gene mutations associated with family Mediterranean fever (FMF) were sought, and a homozygous mutation (M694V) was found in the MFEV gene. This is the novel finding of FMF that masqueraded as cyclic neutropenia. (c) 2008 Wiley-Liss, Inc.

[Comparative study of less invasive stabilization system (LISS) and the condylar support plates for the treatment of AO type C distal femoral fractures in adults].

Science.gov (United States)

Chen, Yu-tao; Yang, Jiang-wei; Hou, Hai-bin; Wang, Chun-sheng; Wang, Kun-zheng

2015-02-01

To summarize the complications and the early clinical effect of less invasive stabilization system and the femoral condylar support plates in the treatment of AO type C distal femoral fractures. From September 2007 to February 2012, 46 patients with AO type C distal femoral fractures were retrospectively studied. Of all patients 25 were treated with less invasive stabilization system including 14 males and 11 females with a mean age of (56.3±4.2) years old; according to AO classification, there were 14 cases of C1, 8 cases of C2 and 3 cases of C3 with a mean hospital stay of (15.6±1.7) days. While 21 cases were treated with femoral condylar support plates fixation including 12 males and 9 females with a mean age of (53.8±5.1) years old;there were 13 cases of C1, 6 cases of C2 and 2 cases of C3 with a mean hospital stay of (17.8±2.2) days. Comparative analysis was performed from the operation related index,postoperative complications and Evanich score of the knee joint function between the two groups at follow-up. All 46 patients were followed up from 13 to 38 months with a mean time of 19.6 months after surgery. Complications included 1 case with infection,3 cases with internal fixation failure, 1 case with nonunion and 1 case with activity limitation of the affected knee. The differences in the incision length, blood loss, fracture healing time were significant between two groups (P0.05). The statistical significance was also found in the Evanich score at last follow-up between two groups (Pfracture healing time and better functional recovery. Less invasive stabilization system had became one of the ideal internal fixations in the treatment of AO type C distal femoral fractures.

Caractérisation de la cinématique et de la dynamique musculaire lors de la marche chez les sujets hémiparétiques : approche par modélisation musculosquelettique.

OpenAIRE

LAMPIRE , Nicolas

2012-01-01

Cette thèse a été réalisée dans le cadre d’une convention CIFRE, marquant la collaboration entre le LBMC (Laboratoire de Biomécanique et Mécanique des Chocs) et le Centre de Médecine Physique et de Réadaptation L’ADAPT Loiret. Le LBMC résulte du rapprochement en janvier 2003 d’une équipe d’enseignants-chercheurs de l’université Claude Bernard Lyon1 et du Laboratoire de Biomécanique et Mécanique des Chocs de l’INRETS (devenu l’IFSTTAR depuis sa fusion ...

Providing innovative solutions in a single pill: Servier's portfolio in hypertension.

Science.gov (United States)

Mourad, Jean-Jacques; Guillerm, Jean-Christophe

2016-09-01

Jean-Jacques Mourad & Jean-Christophe Guillerm speak to Henry Ireland, Drug Evaluation Editor: Jean-Jacques Mourad talks about his vision of the current landscape and unmet medical needs in the field of hypertension. Jean-Christophe Guillerm describes the family of antihypertensive treatments from Servier, which were designed to address the current challenges in the management of hypertension by providing an adapted solution to doctors and to the specific needs of each patient. Jean-Jacques Mourad currently works as Professor of Medicine and is the Head of the Hypertension Unit at the Hôpital Avicenne in Bobigny, France. He completed his academic degrees at the Pierre and Marie Curie University, Paris VI in the field of internal and vascular medicine in 1996, and in the area of cardiovascular medicine and pharmacology in 2001. He is the past president of the French League Against Hypertension (since 2012), and the former General Secretary of the French Microcirculation Society. He is the actual Scientific Secretary of the French Society of Hypertension. He is also a member of the administrative council of the Collège Français de Pathologie Vasculaire. His research focuses on the epidemiology of hypertension, arterial structure and function, determinants of adherence to chronic treatment and the effects of antihypertensive agents. He was involved in several studies and surveys. He is a co-author of more than 130 publications and of 900 communications presented at national and international meetings. Jean-Christophe Guillerm, joined the pharmaceutical industry 17 years ago. He is currently the Head of the Cardiovascular Division for Servier, in charge of both cardiology and hypertension's medical strategy at a global level. Prior to this, he was in charge of the diabetes and internal medicine franchise at a global level. He also has experience in French commercial operations.

Should we screen for masked hypertension in patient with vascular disease?

Directory of Open Access Journals (Sweden)

Pascal Delsart

2010-05-01

Full Text Available Pascal Delsart1, Philippe Marboeuf1, Cedric Delhaye2, Gilles Lemesle2, Claire Mounier-Vehier11Service de Médecine Vasculaire et Hypertension Artérielle, 2Service d’hémodynamique et de Cardiologie B, University Hospital of Lille, FranceBackground: The influence of hypertension on cardiovascular risk is well known. Ambulatory blood pressure measurement (ABPM is able to identify patients with masked hypertension (MH underdetected by clinical BP measurement. The benefit of screening for MH in a highrisk population was investigated.Aims: To detect MH in a population with no prior history of hypertension and medically treated for peripheral or coronary arterial disease.Methods: Thirty-eight consecutive patients with peripheral or coronary artery disease documented with arteriography, without a history of hypertension, and with an admission BP < 140/90 mmHg underwent ABPM after discharge. Ambulatory BP ≥ 125/80 mmHg were defined as MH.Results: MH was found in 11 patients (28.9%. The MH group had a mean systolic and diastolic hospitalization BP significantly higher (127 versus 115 mmHg, respectively, P = 0.002 and 76 versus 66 mmHg, P = 0.01, and tended to have a higher admission systolic BP and pulse pressure (127 versus 121 mmHg, respectively, P = 0.07; and 54 versus 46 mmHg, P = 0.06. The first BP measurement on the 24-hour ABPM was significantly higher in the MH group 140 versus 121 mmHg, P = 0.001, for systolic BP and 84 versus 74 mmHg, P = 0.03, for diastolic BP.Conclusions: MH was found in patients with documented and medically treated vascular disease. BP in the prehypertensive range is associated with MH. Systematic screening for MH in this high-risk population requires further investigation.Keywords: blood pressure, monitoring, masked hypertension, vascular disease

Progesterone increases brain-derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explants.

Science.gov (United States)

Kaur, Paramjit; Jodhka, Parmeet K; Underwood, Wendy A; Bowles, Courtney A; de Fiebre, Nancyellen C; de Fiebre, Christopher M; Singh, Meharvan

2007-08-15

The higher prevalence and risk for Alzheimer's disease in women relative to men has been partially attributed to the precipitous decline in gonadal hormone levels that occurs in women following the menopause. Although considerable attention has been focused on the consequence of estrogen loss, and thus estrogen's neuroprotective potential, it is important to recognize that the menopause results in a precipitous decline in progesterone levels as well. In fact, progesterone is neuroprotective, although the precise mechanisms involved remain unclear. Based on our previous observation that progesterone elicits the phosphorylation of ERK and Akt, key effectors of the neuroprotective mitogen-activated protein kinase (MAPK) and phosphoinositide-3 kinase (PI3-K) pathways, respectively, we determined whether activation of either of these pathways was necessary for progesterone-induced protection. With organotypic explants (slice culture) of the cerebral cortex, we found that progesterone protected against glutamate-induced toxicity. Furthermore, these protective effects were inhibited by either the MEK1/2 inhibitor UO126 or the PI3-K inhibitor LY294002, supporting the requirement for both the MAPK and PI3-K pathways in progesterone-induced protection. In addition, at a concentration and duration of treatment consistent with our neuroprotection data, progesterone also increased the expression of brain-derived neurotrophic factor (BDNF), at the level of both protein and mRNA. This induction of BDNF may be relevant to the protective effects of progesterone, in that inhibition of Trk signaling, with K252a, inhibited the protective effects of progesterone. Collectively, these data suggest that progesterone is protective via multiple and potentially related mechanisms. (c) 2007 Wiley-Liss, Inc. Copyright 2007 Wiley-Liss, Inc.

Reproduction of the salamander Siren intermedia le conte with especial reference to oviducal anatomy and mode of fertilization.

Science.gov (United States)

Sever, David M; Rania, Lisa C; Krenz, John D

1996-03-01

Reproduction was studied in a South Carolina population of the paedomorphic salamander Siren intermedia with emphasis on anatomy of the female oviduct. The oviduct forms 67-79% of the snout-vent length in this elongate species and can be divided into three portions. The atrium, 7-13% of oviducal length, is the narrow anteriormost portion, with the ostial opening immediately caudad of the transverse septum. The ampulla, 63-75% of oviducal length, is the highly convoluted, middle portion in which gelatinous coverings are added to the eggs during their passage. Hypertrophy of the oviducal glands in the ampulla causes the ampulla to increase in diameter during the ovipository season. The secretion of the eosinophilic oviducal glands is intensely positive following staining with the periodic acid-Schiff procedure and does not react with alcian blue at pH 2.5. This staining reaction, coupled with the presence of abundant rough endoplasmic reticulum and Golgi complexes, indicates that the secretion contains a glycoprotein. The ovisac, 16-25% of oviducal length, is the most posterior portion of the oviduct and holds up to 10-11 eggs prior to oviposition. Oviducal glands similar to those in the ampulla are absent in the ovisac. Oviposition in female sirens occurs during February-April in this population, and male spermiation is concurrent. Entire oviducts were sectioned from three females collected during the ovipository season and from two collected prior to the breeding season, and sperm were not found in the oviducts of these specimens. Thus no evidence was found for internal fertilization or sperm storage in the oviducts of sirens. © 1996 Wiley-Liss, Inc. Copyright © 1996 Wiley-Liss, Inc.

Preferred names, preferred pronouns, and gender identity in the electronic medical record and laboratory information system: Is pathology ready?

Directory of Open Access Journals (Sweden)

Katherine L Imborek

2017-01-01

Full Text Available Background: Electronic medical records (EMRs and laboratory information systems (LISs commonly utilize patient identifiers such as legal name, sex, medical record number, and date of birth. There have been recommendations from some EMR working groups (e.g., the World Professional Association for Transgender Health to include preferred name, pronoun preference, assigned sex at birth, and gender identity in the EMR. These practices are currently uncommon in the United States. There has been little published on the potential impact of these changes on pathology and LISs. Methods: We review the available literature and guidelines on the use of preferred name and gender identity on pathology, including data on changes in laboratory testing following gender transition treatments. We also describe pathology and clinical laboratory challenges in the implementation of preferred name at our institution. Results: Preferred name, pronoun preference, and gender identity have the most immediate impact on the areas of pathology with direct patient contact such as phlebotomy and transfusion medicine, both in terms of interaction with patients and policies for patient identification. Gender identity affects the regulation and policies within transfusion medicine including blood donor risk assessment and eligibility. There are limited studies on the impact of gender transition treatments on laboratory tests, but multiple studies have demonstrated complex changes in chemistry and hematology tests. A broader challenge is that, even as EMRs add functionality, pathology computer systems (e.g., LIS, middleware, reference laboratory, and outreach interfaces may not have functionality to store or display preferred name and gender identity. Conclusions: Implementation of preferred name, pronoun preference, and gender identity presents multiple challenges and opportunities for pathology.

Controversy in the allometric application of fixed- versus varying-exponent models: a statistical and mathematical perspective.

Science.gov (United States)

Tang, Huadong; Hussain, Azher; Leal, Mauricio; Fluhler, Eric; Mayersohn, Michael

2011-02-01

This commentary is a reply to a recent article by Mahmood commenting on the authors' article on the use of fixed-exponent allometry in predicting human clearance. The commentary discusses eight issues that are related to criticisms made in Mahmood's article and examines the controversies (fixed-exponent vs. varying-exponent allometry) from the perspective of statistics and mathematics. The key conclusion is that any allometric method, which is to establish a power function based on a limited number of animal species and to extrapolate the resulting power function to human values (varying-exponent allometry), is infused with fundamental statistical errors. Copyright © 2010 Wiley-Liss, Inc.

Procedimientos para la detección e identificación de anticuerpos eritrocitarios

OpenAIRE

Alfonso Valdés , Yalile; Bencomo Hernández, Antonio

2001-01-01

En Inmunohematología se ha desarrollado una amplia gama de procederes de detección e identificación de anticuerpos eritrocitarios in vitro, por lo cual se realiza una revisión de técnicas y métodos empleados con este objetivo, como son el método que utiliza eritrocitos pretratados con enzimas proteolíticas y las técnicas de Polibreno, que utiliza solución de baja fuerza iónica (LISS), la de antiglobulina indirecta, la de aglutinación en gel, la inhibición de la aglutinación, la hemólisis y la...

Imaging learning and memory: classical conditioning.

Science.gov (United States)

Schreurs, B G; Alkon, D L

2001-12-15

The search for the biological basis of learning and memory has, until recently, been constrained by the limits of technology to classic anatomic and electrophysiologic studies. With the advent of functional imaging, we have begun to delve into what, for many, was a "black box." We review several different types of imaging experiments, including steady state animal experiments that image the functional labeling of fixed tissues, and dynamic human studies based on functional imaging of the intact brain during learning. The data suggest that learning and memory involve a surprising conservation of mechanisms and the integrated networking of a number of structures and processes. Copyright 2001 Wiley-Liss, Inc.

The peacock's train (Pavo cristatus and Pavo cristatus mut. alba) II. The molecular parameters of feather keratin plasticity.

Science.gov (United States)

Weiss, Ingrid M; Schmitt, Karl P; Kirchner, Helmut O K

2011-06-01

Thermal activation analysis of plastic deformation of peacock tail feathers, by temperature changes and stress relaxation, gave for the keratin cortex an activation enthalpy of 1.78 ± 0.89 eV and an activation volume of 0.83 ± 0.13 nm³, for both the blue and the white subspecies. These values suggest that breaking of electrostatic bonds is responsible for plasticity in feather keratin. These might be bonds between keratin and nonkeratinous matrix or keratin-keratin cross-links. The mechanical properties of the rachis cortex are surprisingly uniform along the length of the feathers. Copyright © 2011 Wiley-Liss, Inc., A Wiley Company.

Global issues and opportunities for optimized retinoblastoma care.

Science.gov (United States)

Gallie, Brenda L; Zhao, Junyang; Vandezande, Kirk; White, Abigail; Chan, Helen S L

2007-12-01

The RB1 gene is important in all human cancers. Studies of human retinoblastoma point to a rare retinal cell with extreme dependency on RB1 for initiation but not progression to full malignancy. In developed countries, genetic testing within affected families can predict children at high risk of retinoblastoma before birth; chemotherapy with local therapy often saves eyes and vision; and mortality is 4%. In less developed countries where 92% of children with retinoblastoma are born, mortality reaches 90%. Global collaboration is building for the dramatic change in mortality that awareness, simple expertise and therapies could achieve in less developed countries. Copyright 2007 Wiley-Liss, Inc.

Could cognitive vulnerability identify high-risk subjects for schizophrenia?

Science.gov (United States)

Sarfati, Yves; Hardy-Baylé, Marie-Christine

2002-12-08

This review puts into questions the possible role of cognitive vulnerability markers in prediction and prevention of schizophrenia. Until recently, none of the identified cognitive anomalies has been proved to be definitive. However, as new promising candidates are emerging (DS-CPT, CPT-IP, P suppression, Saccadic Eye Movements), the predictive value of these trait-type anomalies may be criticized regarding four issues, which are discussed: technical, metrological, theoretical, and clinical. As things stand, the existence of a cognitive vulnerability marker, which testify to a permanent pathological trait, does not constitute a sufficient factor to identify and treat subjects who are at risk for schizophrenia. Copyright 2002 Wiley-Liss, Inc.

Pulsed-dosing with oral sodium phenylbutyrate increases hemoglobin F in a patient with sickle cell anemia.

Science.gov (United States)

Hines, Patrick; Dover, George J; Resar, Linda M S

2008-02-01

Increasing hemoglobin F (HbF) appears to be beneficial for patients with sickle cell anemia. We previously demonstrated that daily, oral sodium phenylbutyrate (OSPB) induces HbF synthesis in pediatric and adult patients with hemoglobin SS (HbSS). The high doses and need for daily therapy, however, have limited its use. Here, we report a patient treated with pulsed-dosing of OSPB for over 3 years. This patient developed a modest, but sustained elevation in HbF over the course of therapy without side effects. Although larger studies are needed, this case demonstrates that pulsed-dosing with OSPB enhances HbF synthesis. (c) 2007 Wiley-Liss, Inc.

Feature-Space Clustering for fMRI Meta-Analysis

DEFF Research Database (Denmark)

Goutte, Cyril; Hansen, Lars Kai; Liptrot, Mathew G.

2001-01-01

MRI sequences containing several hundreds of images, it is sometimes necessary to invoke feature extraction to reduce the dimensionality of the data space. A second interesting application is in the meta-analysis of fMRI experiment, where features are obtained from a possibly large number of single......-voxel analyses. In particular this allows the checking of the differences and agreements between different methods of analysis. Both approaches are illustrated on a fMRI data set involving visual stimulation, and we show that the feature space clustering approach yields nontrivial results and, in particular......, shows interesting differences between individual voxel analysis performed with traditional methods. © 2001 Wiley-Liss, Inc....

World disparities in risk definition and management of retinoblastoma: a report from the International Retinoblastoma Staging Working Group.

Science.gov (United States)

Chantada, Guillermo L; Doz, François; Orjuela, Manuela; Qaddoumi, Ibrahim; Sitorus, Rita S; Kepak, Tomas; Furmanchuk, Anna; Castellanos, Mauricio; Sharma, Tarun; Chevez-Barrios, Patricia; Rodriguez-Galindo, Carlos

2008-03-01

Following from the publication of the International Retinoblastoma Staging System, an open internet discussion group was created at the www.cure4kids.org resource. The results of a survey distributed among participants are discussed. Although most patients with retinoblastoma were treated under prospective protocols, there was a wide variation in the definition of risk criteria and in the criteria for giving adjuvant chemotherapy following enucleation. Definition of high-risk histological features and the criteria for use of adjuvant therapy will be standardized in future studies. Internet meetings are a valuable mechanism for enabling participation from under-resourced countries in the development of cooperative studies. (c) 2007 Wiley-Liss, Inc.

Genetic heterogeneity of hepatitis E virus in Darfur, Sudan, and neighboring Chad.

Science.gov (United States)

Nicand, Elisabeth; Armstrong, Gregory L; Enouf, Vincent; Guthmann, Jean Paul; Guerin, Jean-Philippe; Caron, Mélanie; Nizou, Jacques Yves; Andraghetti, Roberta

2005-12-01

The within-outbreak diversity of hepatitis E virus (HEV) was studied during the outbreak of hepatitis E that occurred in Sudan in 2004. Specimens were collected from internally displaced persons living in a Sudanese refugee camp and two camps implanted in Chad. A comparison of the sequences in the ORF2 region of 23 Sudanese isolates and five HEV samples from the two Chadian camps displayed a high similarity (>99.7%) to strains belonging to Genotype 1. But four isolates collected in one of the Chadian camps were close to Genotype 2. Circulation of divergent strains argues for possible multiple sources of infection. Copyright (c) 2005 Wiley-Liss, inc.

Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management.

Science.gov (United States)

Nur, Erfan; Biemond, Bart J; Otten, Hans-Martin; Brandjes, Dees P; Schnog, John-John B

2011-06-01

Sickle cell disease (SCD) is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and vaso-occlusion leading to a reduced quality of life and life expectancy. Oxidative stress is an important feature of SCD and plays a significant role in the pathophysiology of hemolysis, vaso-occlusion and ensuing organ damage in sickle cell patients. Reactive oxygen species (ROS) and the (end-)products of their oxidative reactions are potential markers of disease severity and could be targets for antioxidant therapies. This review will summarize the role of ROS in SCD and their potential implication for SCD management. Copyright © 2011 Wiley-Liss, Inc.

Distribution of model-based multipoint heterogeneity lod scores.

Science.gov (United States)

Xing, Chao; Morris, Nathan; Xing, Guan

2010-12-01

The distribution of two-point heterogeneity lod scores (HLOD) has been intensively investigated because the conventional χ(2) approximation to the likelihood ratio test is not directly applicable. However, there was no study investigating th e distribution of the multipoint HLOD despite its wide application. Here we want to point out that, compared with the two-point HLOD, the multipoint HLOD essentially tests for homogeneity given linkage and follows a relatively simple limiting distribution ½χ²₀+ ½χ²₁, which can be obtained by established statistical theory. We further examine the theoretical result by simulation studies. © 2010 Wiley-Liss, Inc.

Majewski osteodysplastic primordial dwarfism type II (MOPD II) complicated by stroke: clinical report and review of cerebral vascular anomalies.

Science.gov (United States)

Brancati, Francesco; Castori, Marco; Mingarelli, Rita; Dallapiccola, Bruno

2005-12-15

We report on a 2 9/12-year-old boy with disproportionate short stature, microcephaly, subtle craniofacial dysmorphisms, and generalized skeletal dysplasia, who developed a left hemiparesis. Brain neuroimaging disclosed a complex cerebral vascular anomaly (CVA) with stenosis of the right anterior cerebral artery and telangiectatic collateral vessels supplying the cerebral cortex, consistent with moyamoya disease. Based on clinical and skeletal features, a diagnosis of Majewski osteodysplastic primordial dwarfism type II (MOPD II) was established. Review of 16 published patients with CVA affected by either Seckel syndrome or MOPD II suggested that CVA is preferentially associated to the latter subtype affecting about 1/4 of the patients. 2005 Wiley-Liss, Inc.

The inter-relations of mother and father attachment, self-esteem and aggression during late adolescence.

Science.gov (United States)

Gomez, Rapson; McLaren, Suzanne

2007-01-01

This study examined three models depicting the relations between mother and father attachment, self-esteem and aggression. A total of 385 participants (173 males and 212 females), aged from 18 to 20 years, completed self-rating questionnaires covering mother and father attachment, self-esteem and aggression. Results showed that self-esteem had additive and mediation effects on both the father attachment-aggression and mother attachment-aggression relationships, and also moderated the mother attachment-aggression relation. These findings are discussed in terms of different models for the inter-relations of mother and father attachment, self-esteem and aggression in late adolescence. Copyright 2006 Wiley-Liss, Inc.

Neurobehavioral effects among subjects exposed to high static and gradient magnetic fields from a 1.5 Tesla magnetic resonance imaging system--a case-crossover pilot study.

Science.gov (United States)

de Vocht, Frank; van-Wendel-de-Joode, Berna; Engels, Hans; Kromhout, Hans

2003-10-01

The interactive use of magnetic resonance imaging (MRI) techniques is increasing in operating theaters. A study was performed on 17 male company volunteers to assess the neurobehavioral effects of exposure to magnetic fields from a 1.5 Tesla MRI system. The subjects' neurobehavioral performances on a neurobehavioral test battery were compared in four 1-hr sessions with and without exposure to magnetic fields, and with and without additional movements. Adverse effects were found for hand coordination (-4%, P Tesla MRI system may lead to neurobehavioral effects. Further research is recommended, especially in members of operating teams using interactive MRI systems. Copyright 2003 Wiley-Liss, Inc.

The principles of teratology: are they still true?

Science.gov (United States)

Friedman, Jan M

2010-10-01

James Wilson originally proposed a set of "Principles of Teratology" in 1959, the year before he helped to found the Teratology Society. By 1977, when these Principles were presented in a more definitive form in Wilson and Fraser's Handbook of Teratology, they had become a standard formulation of the basic tenets of the field. Wilson's Principles have continued to guide scientific research in teratology, and they are widely used in teaching. Recent advances in our knowledge of the molecular and cellular bases of embryogenesis serve only to provide a deeper understanding of the fundamental developmental mechanisms that underlie Wilson's Principles of Teratology. © 2010 Wiley-Liss, Inc.

Biological activity of the functional epitope of ciguatoxin fragment AB on the neuroblastoma sodium channel in tissue culture.

Science.gov (United States)

Hokama, Y; Chun, K E; Campora, C E; Higa, N; Suma, C; Hamajima, A; Isobe, M

2006-01-01

It is well established that the targeted receptor for ciguatoxin (CTX) in mammalian tissues is the sodium channel, affecting the influx of sodium into cells and altering the action potential and function of the cell. Since the syntheses of fragments of CTX has become available, our focus has been on the receptor functions of the west sphere AB and east sphere JKLM fragments using the neuroblastoma cell assay, guinea pig atrium assay, and the membrane immunobead assay (MIA). The data presented here suggest that the west sphere AB of the ciguatoxin molecule is the active portion and is responsible for the activation of the sodium channels. (c) 2006 Wiley-Liss, Inc.

Four novel ELANE mutations in patients with congenital neutropenia.

Science.gov (United States)

Kurnikova, Maria; Maschan, Michael; Dinova, Evgeniya; Shagina, Irina; Finogenova, Natalia; Mamedova, Elena; Polovtseva, Tatyana; Shagin, Dmitry; Shcherbina, Anna

2011-08-01

Congenital neutropenia is a heterogeneous bone marrow failure syndrome characterized by a maturation arrest of myelopoesis at the promyelocyte/myelocyte stage. Cyclic neutropenia (CyN) and severe congenital neutropenia (SCN) are two main forms of congenital neutropenia. Genetic analysis has shown that heterozygous mutations in the ELANE gene encoding the neutrophil elastase are the major cause of these disorders. We investigated the prevalence of ELANE mutations in a group of 16 patients from 14 families with congenital neutropenia. Five patients had typical manifestations of CyN, and 11 patients had SCN. Seven different heterozygous ELANE mutations were found, including four novel mutations. Copyright © 2011 Wiley-Liss, Inc.

Stem cell therapy: MRI guidance and monitoring.

Science.gov (United States)

Kraitchman, Dara L; Gilson, Wesley D; Lorenz, Christine H

2008-02-01

With the recent advances in magnetic resonance (MR) labeling of cellular therapeutics, it is natural that interventional MRI techniques for targeting would be developed. This review provides an overview of the current methods of stem cell labeling and the challenges that are created with respect to interventional MRI administration. In particular, stem cell therapies will require specialized, MR-compatible devices as well as integration of graphical user interfaces with pulse sequences designed for interactive, real-time delivery in many organs. Specific applications that are being developed will be reviewed as well as strategies for future translation to the clinical realm. (Copyright) 2008 Wiley-Liss, Inc.

Molecular cytogenetic characterization and origin of two de novo duplication 9p cases.

Science.gov (United States)

Tsezou, A; Kitsiou, S; Galla, A; Petersen, M B; Karadima, G; Syrrou, M; Sahlèn, S; Blennow, E

2000-03-13

We report on two additional cases with duplication of 9p, minor with facial anomalies and developmental delay. Using fluorescence in situ hybridization and single-copy probes, we showed that the first case was a direct duplication, whereas the second case was inverted. The extent of the direct duplication was defined as 9p12 --> p24 by microdissection and microcloning of the aberrant chromosome and subsequent chromosome-specific comparative genomic hybridization. DNA polymorphism analysis with eight microsatellite markers revealed that the origin of the dup(9p) was maternal in the first case, whereas it was paternal in the second. Copyright 2000 Wiley-Liss, Inc.

Pulmonary Vascular Defects in Congenital Diaphragmatic Hernia : the quest for early factors and intervention : Pulmonale vasculaire defecten in congenitale hernia diafragmatica : de zoektocht naar vroege factoren en interventie

NARCIS (Netherlands)

D.S. Mous (Daphne)

2017-01-01

markdownabstractCongenital diaphragmatic hernia (CDH) is a severe anomaly characterized by a diaphragmatic defect, lung hypoplasia and pulmonary hypertension. The associated pulmonary abnormalities are responsible for the high morbidity and mortality among patients with this disease. Vasodilator

Integrated approach of the metabolism and the muscle perfusion in imaging and magnetic resonance spectroscopy; Approche integree du metabolisme et de la perfusion musculaire en imagerie et spectroscopie par resonance magnetique nucleaire

Energy Technology Data Exchange (ETDEWEB)

Brillault-Salvat, C

1997-12-16

Oxygen is necessary to the tissue life. Every step from its transport of the ambient medium to its consumption by cells are essential to the right functioning of organism. The involved phenomena are complex and use numerous different mechanisms. In order to better understand the functioning, it has been developed a non traumatic, non irradiating and quantitative method that allows to measure in the same time several determinants of the tissue oxygenation. (N.C.)

Charge exchange laboratory studies relevant to solar-wind-induced cometary and planetary X-ray emission

Science.gov (United States)

Eissa, Farhat

The discovery of cometary X-ray emission for the first time in 1996, from comet Hyukatake using the Röntgen satellite (ROSAT) [Lisse, C. M. et al., 1996] was a highly surprising event. Since then, X-ray and extreme ultra violet (X-EUV) emission has been observed from a number of comets [Lisse, C. M. et al., 2001]. The production of such radiation is strongly believed to be the result of the charge exchange collisions of the minor heavy highly charged solar wind (SW) ions with cometary neutrals. This study reports the first state-selective He- like X-ray spectra resulting from single-electron capture (SEC) in charge exchange collisions of O 7+ and Ne 9+ with He and CO targets at a collision velocity of 800 km/s. The ions and velocity are typical of solar wind ions while the molecular and atomic targets are typical of cometary (CO) and interstellar (He) neutrals. The spectra have been obtained by means of simultaneous cold-target recoil ion momentum spectroscopic (COLTRIMS) and X-ray spectroscopic measurements that involved the triple-coincident detection of X- rays, scattered projectile, and target recoil ions. The spectra test the ability of theories to account for the relative population of triplet and singlet states in He-like product ions following SEC. The O 7+ +He spectra are compared with theoretical spectra based on quantal molecular-orbital close- coupling (QMOCC) and multi-channel Landau-Zener (MCLZ) calculations. In addition, all spectra have been used to extract angular momentum distributions based on the traditional 3:1 triplet-to-singlet ratio assumption for the populated states. The QMOCC and MCLZ calculations and the experimental results, however, suggest significant departures from this assumption. The extracted l - distributions are state-of-the-art at this time for modeling purposes due to the high differentiation power of the experimental procedure.

In reactor measurements, modeling and assessments to predict liquid injection shutdown system nozzle to Calandria tube time to contact

International Nuclear Information System (INIS)

Kirstein, K.; Kalenchuk, D.

2011-01-01

Over the past few years there has been an expanding effort to assess the potential for Calandria Tubes (CTs) coming into contact with Liquid Injection Shutdown System (LISS) Nozzles to ensure continued contact-free operation as required by CSA N285.4. LISS Nozzles (LINs), which run perpendicular to and between rows of fuel channels, sag at a slower rate than the fuel channels. As a result certain LINs may come in contact with CTs above them. The CT/LIN gaps can be predicted from calculated CT sag, LIN sag and a number of component and installation tolerances. This method however results in very conservative predictions when compared to measurements, confirmed with the in reactor measurements initiated in 2000, when gaps were successfully measured the first time using images obtained from a camera-assisted measurement tool inserted into the calandria. To reduce the conservatism of the CT/LIN gap predictions, statistical CT/LIN gap models are used instead. They are derived from a comparison between calculated gaps based on nominal dimensions and the visual image based measured gaps. These reactor specific (typically 95% confidence level) CT/LIN gap models account for all uncertainties and deviations from nominal values. Prediction error margins reduce as more in-reactor gap measurements become available. Each year more measurements are being made using this standardized visual CT/LIN proximity method. The subsequently prepared reactor-specific models have been used to provide time to contact for every channel above the LINs at these stations. In a number of cases it has been used to demonstrate that the reactor can be operated to its end of life before refurbishment with no predicted contact, or specific at-risk channels have been identified for which appropriate remedial actions could be implemented in a planned manner. (author)

Subsistence patterns and blood pressure variation in two rural Caboclo communities of Marajó Island, Pará, Brazil.

Science.gov (United States)

Silva, Hilton P; Crews, Douglas E; Neves, Walter A

1995-01-01

Blood pressure (BP) increases with age in westernized societies, is higher in men, and is correlated with the body mass index (BMI). Traditional societies present more variable patterns of BP. In 1991, BP and anthropometric data from two "Caboclo" (rural populations of mixed ancestry) groups from Marajó Island, Brazil, were collected: The Paricatuba group, (N = 20;12 women), with a subsistence base of fishing, collection of palm fruits, and traditional gardening; and the Praia Grande group (N = 26; 14 women), where subsistence is based on mechanized agriculture. In Paricatuba, mean BP is 109/74 mmHg in men and 101/70 mmHg in women. There are no significant differences between BP of men and women, and systolic blood pressure (SBP) increases with age. Both SBP and diastolic blood pressure (DBP) are associated with weight, but only DBP is associated with the BMI, while SBP is associated with stature. In Praia Grande, mean BP is 120/76 mmHg in men and 118/70 mmHg in women, with no significant differences between the sexes. In Praia Grande, SBP is higher than in Paricatuba, and both SBP and DBP are associated with age. Compared with urban groups, both Caboclo samples have low BP. Still, differences in BP and body habitus between the two groups support a hypothesis that degree of westernization influences mean levels of BP in rural Amazonian populations. Further, the results also may be interpreted as suggesting that associations of sex, age, and BMI with BP, commonly reported in urban samples, are a byproduct of westernization rather than a result of genetic factors. © 1995 Wiley-Liss, Inc. Copyright © 1995 Wiley-Liss, Inc., A Wiley Company.

Swift and sure-footed on the Savanna: A study of Hadzabe gaits and feet in Northern Tanzania.

Science.gov (United States)

Musiba, Charles M; Tuttle, Russell H; Hallgrímsson, Benedikt; Webb, David M

1997-01-01

Data on footprints and gait of 54 Hadzabe, 6-70 years of age expand understanding of pedal morphology of unshod people and assist the development of ideas about the evolution of hominid bipedality and upright posture. Contrary to published data on gaits and pedal morphology of unshod populations, Hadzabe (also known as Hadza) from northern Tanzania exhibit values of stride length, relative stride length, and walking speeds that exceed those of rural and small-town populations. In all observable plantar features, including foot indices, an interdigital space between the hallux and second toe, fanning of the foot anteriorly, and foot angles (in-toeing and out-toeing), Hadzabe feet are comparable with those of never-shod Machiguengas in Perú. On average, Hadzabe hallucal gaps and ball widths are narrower than those of Machiguengas and other unshod short people. Hadzabe feet are also characterized by valgus halluces versus the varus halluces of never-shod Machiguengas and certain West Africans. Although characterized by a valgus toe, Hadzabe hallucal angles, which do not exceed 20°, are lower than those of Northern Hemispheric urbanites and shod rural populations of the Southern and Northern Hemispheres. Hadzabe also exhibit less medial and lateral rotation of the hip joint than Machiguengas do. The heel and the longitudinal arch impressions of the Hadzabe footprints closely resemble those of the Laetoli bipeds in the manner of weight distribution during locomotion. The striking similarity of footprint impressions, especially the heel and the longitudinal arch, between Hadzabe and Laetoli hominid footprints clearly imply that the pedal features of the Laetoli printmakers are remarkably humanoid. Am. J. Hum. Biol. 9:303-321, 1997. © 1997 Wiley-Liss, Inc. Copyright © 1997 Wiley-Liss, Inc.

Occupational health hazards in the interventional laboratory: Time for a safer environment.

Science.gov (United States)

Klein, Lloyd W; Miller, Donald L; Balter, Stephen; Laskey, Warren; Naito, Neil; Haines, David; Ross, Allan; Mauro, Matthew A; Goldstein, James A

2018-01-04

Over the past 30 years, the advent of fluoroscopically guided interventional procedures has resulted in dramatic increments in both X-ray exposure and physical demands that predispose interventionists to distinct occupational health hazards. The hazards of accumulated radiation exposure have been known for years, but until recently the other potential risks have been ill-defined and under-appreciated. The physical stresses inherent in this career choice appear to be associated with a predilection to orthopedic injuries, attributable in great part to the cumulative adverse effects of bearing the weight and design of personal protective apparel worn to reduce radiation risk and to the poor ergonomic design of interventional suites. These occupational health concerns pertain to cardiologists, radiologists and surgeons working with fluoroscopy, pain management specialists performing nonvascular fluoroscopic procedures, and the many support personnel working in these environments. This position paper is the work of representatives of the major societies of physicians who work in the interventional laboratory environment, and has been formally endorsed by all. In this paper, the available data delineating the prevalence of these occupational health risks is reviewed and ongoing epidemiological studies designed to further elucidate these risks are summarized. The main purpose is to publicly state speaking with a single voice that the interventional laboratory poses workplace hazards that must be acknowledged, better understood and mitigated to the greatest extent possible, and to advocate vigorously on behalf of efforts to reduce these hazards. Interventional physicians and their professional societies, working together with industry, should strive toward the ultimate zero radiation exposure work environment that would eliminate the need for personal protective apparel and prevent its orthopedic and ergonomic consequences. © 2008 Wiley-Liss, Inc. Copyright © 2008 Wiley‐Liss

3,3'-Diaryl-BINOL phosphoric acids as enantioselective extractants of benzylic primary amines.

Science.gov (United States)

Verkuijl, Bastiaan J V; de Vries, Johannes G; Feringa, Ben L

2011-01-01

We report that 3,3'-diaryl-BINOL phosphoric acids are effective enantioselective extractants in chiral separation methods based on reactive liquid-liquid extraction. These new extractants are capable of separating racemic benzylic primary amine substrates. The effect of the nature of the substituents at the 3,3'-positions of the host were examined as well as the structure of the substrate, together with important parameters such as the organic solvent, the pH of the aqueous phase, and the host stoichiometry. Titration of the substrate with the host was monitored by FTIR, NMR, UV-Vis, and CD spectroscopy, which provided insight into the structure of the host-guest complex involved in extraction. Copyright © 2010 Wiley-Liss, Inc.

Malignant pleural mesothelioma in bakers and pastry cooks.

Science.gov (United States)

Ascoli, V; Calisti, R; Carnovale-Scalzo, C; Nardi, F

2001-10-01

The occurrence of malignant pleural mesothelioma (MPM) among bakers and pastry cooks has never been documented. We detected eight cases of MPM in bakers, pastry cooks, and biscuit cooks engaged in making, baking/cooking, and selling pastry/bread in two hospital-based series (Rome and Orbassano/Turin, Italy; period 1990-1997; 222 cases). Field-investigations revealed asbestos-containing material (ACM) in ovens for baking bread, that were manufactured prior to the 1980s. It is suggested that there is a possible new association of the risk of having worked as a baker or pastry cook and MPM. Presumptive source of exposure to asbestos was the use of asbestos-insulated ovens. Copyright 2001 Wiley-Liss, Inc.

Multiple hemangiomas in a patient with a t(3q;4p) translocation: an infrequent association with Wolf-Hirschhorn syndrome.

Science.gov (United States)

Pardo, Sherly; Blitman, Netta; Han, Bokyung; Cohen, Ninette; Edelmann, Lisa; Hirschhorn, Kurt

2008-01-15

We report on the clinical phenotype of an infant with a duplication of the terminal portion of the long arm of chromosome 3(q26.3-qter) and a deletion of the terminal portion of the short arm of chromosome 4(p16.3) with multiple hemangiomas and a hamartoma. Patients with deletions of distal 4p have the characteristic features of Wolf-Hirschhorn syndrome (WHS); whereas those with the distal duplication of 3q have a well recognized syndrome with some features resembling Cornelia-de Lange syndrome (CdLS). Neither of these recognized chromosomal anomalies has been reported previously to be associated with multiple hemangiomas or other vascular malformations. (c) 2007 Wiley-Liss, Inc.

Combining regio- and enantioselectivity of lipases for the preparation of (R)-4-chloro-2-butanol.

Science.gov (United States)

Méndez, Jonh J; Oromi, Mireia; Cervero, Maria; Balcells, Mercè; Torres, Mercè; Canela, Ramon

2007-01-01

Preparation of 98% ee (R)-4-chloro-2-butanol was carried out by the enzymatic hydrolysis of chlorohydrin esters, using fungal resting cells and commercial enzymes. Hydrolyzes were carried out using lipases from Candida antarctica (Novozym 435), C. rugosa, Rhizomucor miehei (Lipozyme IM), Burkolia cepacia, and resting cells of Rhizopus oryzae and Aspergillus flavus. The influence of the enzyme, the solvent, the temperature, and the alkyl chain length on the selectivity of hydrolyzes of isomeric mixtures of chlorohydrin esters is described. Regioselectivity was higher than 95% for some of the tested lipases. Novozym 435 allowed preparation of the (R)-4-chloro-2-butanol after 15 min of reaction at 30-40 degrees C. (c) 2006 Wiley-Liss, Inc.

Recurrent SOX9 deletion campomelic dysplasia due to somatic mosaicism in the father.

Science.gov (United States)

Smyk, M; Obersztyn, E; Nowakowska, B; Bocian, E; Cheung, S W; Mazurczak, T; Stankiewicz, P

2007-04-15

Haploinsufficiency of SOX9, a master gene in chondrogenesis and testis development, leads to the semi-lethal skeletal malformation syndrome campomelic dysplasia (CD), with or without XY sex reversal. We report on two children with CD and a phenotypically normal father, a carrier of a somatic mosaic SOX9 deletion. This is the first report of a mosaic deletion of SOX9; few familial CD cases with germline and somatic mutation mosaicism have been described. Our findings confirm the utility of aCGH and indicate that for a more accurate estimate of the recurrence risk for a completely penetrant autosomal dominant disorder, parental somatic mosaicism should be considered in healthy parents. Copyright 2007 Wiley-Liss, Inc.

The role of maternal responsivity in the development of children with intellectual disabilities.

Science.gov (United States)

Warren, Steven F; Brady, Nancy C

2007-01-01

There is growing evidence that cumulative exposure to highly responsive parenting styles throughout the early childhood period may provide a variety of important child benefits in terms of language, cognitive, social, and emotional development. We view maternal responsivity as a dynamic construct of central importance to the development of children with intellectual disabilities just as it is for typically developing children. In this study, we selectively review the theoretical and conceptual evidence for the effects of responsivity on development, discuss factors known to influence responsivity including the nature of a child's disability, and review intervention approaches intended to enhance maternal responsivity. We conclude with a set of recommendations for future research. (c) 2007 Wiley-Liss, Inc.

Dandy-Walker variant in Coffin-Siris syndrome.

Science.gov (United States)

Imai, T; Hattori, H; Miyazaki, M; Higuchi, Y; Adachi, S; Nakahata, T

2001-04-22

We describe a five-month-old male infant with Coffin-Siris syndrome, the so-called Dandy-Walker variant (hypoplasia of the cerebellar vermis with cystic dilatation of the fourth ventricle, but without enlargement of the posterior fossa), and partial agenesis of the corpus callosum. Dandy-Walker malformation and mega cisterna magna, but not Dandy-Walker variant, have been reported in Coffin-Siris syndrome. The presence of Dandy-Walker variant in the infant we described confirms that the full continuum of the Dandy-Walker complex can occur in Coffin-Siris syndrome. The yet unidentified gene(s) for the syndrome may be related to the development of the hindbrain. Copyright 2001 Wiley-Liss, Inc.

Genetic drift. The real tiger mother: from the clinical geneticist's perspective.

Science.gov (United States)

Shur, Natasha

2011-09-01

The Battle Hymn of the Tiger Mother by Amy Chua raises questions about motherhood and what is admirable. Chua promotes strict, Old World, uncompromising values stressing academic performance above all, insisting on drilling and practice, and instilling respect for authority. As clinical geneticists, we meet an entirely different type of mother than Chua, the clinical genetics mother who fights illnesses, schools, hospital policies, and insurance companies. She battles not against her child but for her child. With brilliance and resilience, she creates a child-centered world. The stories of four clinical genetics mothers rally us to reject extreme parenting and appreciate the simple joys of childhood. Copyright © 2011 Wiley-Liss, Inc.

Transmission X-ray microscopy for full-field nano imaging of biomaterials.

Science.gov (United States)

Andrews, Joy C; Meirer, Florian; Liu, Yijin; Mester, Zoltan; Pianetta, Piero

2011-07-01

Imaging of cellular structure and extended tissue in biological materials requires nanometer resolution and good sample penetration, which can be provided by current full-field transmission X-ray microscopic techniques in the soft and hard X-ray regions. The various capabilities of full-field transmission X-ray microscopy (TXM) include 3D tomography, Zernike phase contrast, quantification of absorption, and chemical identification via X-ray fluorescence and X-ray absorption near edge structure imaging. These techniques are discussed and compared in light of results from the imaging of biological materials including microorganisms, bone and mineralized tissue, and plants, with a focus on hard X-ray TXM at ≤ 40-nm resolution. Copyright © 2010 Wiley-Liss, Inc.

Reduction of the Earth's magnetic field inhibits growth rates of model cancer cell lines.

Science.gov (United States)

Martino, Carlos F; Portelli, Lucas; McCabe, Kevin; Hernandez, Mark; Barnes, Frank

2010-12-01

Small alterations in static magnetic fields have been shown to affect certain chemical reaction rates ex vivo. In this manuscript, we present data demonstrating that similar small changes in static magnetic fields between individual cell culture incubators results in significantly altered cell cycle rates for multiple cancer-derived cell lines. This change as assessed by cell number is not a result of apoptosis, necrosis, or cell cycle alterations. While the underlying mechanism is unclear, the implications for all cell culture experiments are clear; static magnetic field conditions within incubators must be considered and/or controlled just as one does for temperature, humidity, and carbon dioxide concentration. Copyright © 2010 Wiley-Liss, Inc.

Contributions to the Data Warehouse 2 and Prospects of the IRS Program

Science.gov (United States)

Barner, Frithjof; Venkataraman, V. Raghu; Makiola, Jens

2016-08-01

During 2015 and 2016, the IRS program has significantly contributed to the CSC-DA Data Warehouse. From its suite of optical EO satellites which operate in the visible, near IR and shortwave IR domain, data from the HR LISS-III and MR AWiFS sensors on board of Resourcesat-2 have been provided. Resourcesat-2 so far acquired cloud-free images of a vast majority of the first and second coverage of HR_IMAGE_2015 and several monthly MR coverages for MR_IMAGE_2015 over the EEA-39. The results regarding the above mentioned data sets will be discussed including an appraisal of the possible future role of upcoming IRS EO satellites for European data requirements.

Role of epigenetics in developmental biology and transgenerational inheritance.

Science.gov (United States)

Skinner, Michael K

2011-03-01

The molecular mechanisms involved in developmental biology and cellular differentiation have traditionally been considered to be primarily genetic. Environmental factors that influence early life critical windows of development generally do not have the capacity to modify genome sequence, nor promote permanent genetic modifications. Epigenetics provides a molecular mechanism for environment to influence development, program cellular differentiation, and alter the genetic regulation of development. The current review discusses how epigenetics can cooperate with genetics to regulate development and allow for greater plasticity in response to environmental influences. This impacts area such as cellular differentiation, tissue development, environmental induced disease etiology, epigenetic transgenerational inheritance, and the general systems biology of organisms and evolution. Copyright © 2011 Wiley-Liss, Inc.

Body symmetry and asymmetry in early Greek anatomical reasoning.

Science.gov (United States)

Crivellato, Enrico; Ribatti, Domenico

2008-05-01

This historical note focuses on some of the earliest reports of human anatomy found in Greek medical literature. These passages testify the initial steps taken by Greek scientists in building a theoretical model of the human body. In these excerpts, one finds erroneous anatomical descriptions, which shed light on the epistemological approach used by these intellectual pioneers. Because of the lack of systematic dissection, it appears that early Greek anatomists developed a somewhat stylized idea of the human body that used a certain degree of symmetry. Overcoming the concept of a strict left-right bilateral parallelism in human body architecture was a challenging intellectual task that required prolonged observation of dissected corpses. (c) 2008 Wiley-Liss, Inc.

Cyclic resolution of racemic ibuprofen via coupled efficient lipase and acid-base catalysis.

Science.gov (United States)

Liu, Ying; Wang, Fang; Tan, Tianwei

2009-03-01

Extracellular lipase LIP prepared in our lab from the yeast Yarrowia lipolytica was used for the resolution of racemic ibuprofen. The (S)-enantiomer was preferred by lipase LIP, and the unreacted (R)-enantiomer was extracted and racemized in basic solvent-water medium to be re-resolved. Solvent, content of solvent, base concentration, and temperature have a strong effect on racemization. The (S)-ester was separated and hydrolyzed to (S)-ibuprofen in acidic dimethyl sulfoxide-water mixture containing 70% dimethyl sulfoxide. The high purity (S)-ibuprofen (ee = 0.98) was obtained using lipase LIP to catalyze hydrolysis of (S)-ester in 0.1 M phosphate buffer (pH = 8). (c) 2008 Wiley-Liss, Inc.

Morphological and biometric comparison of the scales of the barbels (Barbus cuvier) of Spain.

Science.gov (United States)

Miranda, R; Escala, M

2000-09-01

The scales of 386 specimens of the eight species of the genus Barbus present in Spain (B. bocagei, B. comiza, B. graellsii, B. guiraonis, B. haasi, B. meridionalis, B. microcephalus, and B. sclateri) were studied. Six scales were extracted from each specimen, measurements taken, and the number of radii noted. Indices were obtained from these data. Statistical analysis allowed two groups to be established: 1) B. meridionalis and B. haasi, living in the upper stretches of rivers and distributed in the north of Spain; and 2) the remaining species. Within both groups a latitudinal gradation in the elongation of the scales and in the proportion of radii of the lateral fields was observed. Copyright 2000 Wiley-Liss, Inc.

Evaporation of refrigerant HFC 407C on plain tubes or at an improved surface; Evaporation du refrigerant HFC 407C sur des tubes lisses ou a surface amelioree

Energy Technology Data Exchange (ETDEWEB)

Zuercher, O.; Favrat, D.; Thome, J. R.; Kattan, N.; Nidegger, E. [Ecole polytechnique federale, Lab. d` energetique industrielle, Lausanne (Switzerland)

1996-11-15

The substitution of CFC refrigerants in refrigeration systems, heat pumps and organic Rankine cycles for heat recovery, requires good methods for predicting heat transfer of substitute fluids. The measurements in the LENI test facility (concentric tubes with water flowing in a counter-current flow) with HFC 407C, HFC 134a, HCFC 123, HFC 404a and HFC/HCFC 402A provide a new data bank for new refrigerants, and allow a coherent comparison with old refrigerants CFC 11, CFC 12, CFC/HCFC 502 and with existing correlations. The existing correlations were found to be inadequate. Because of this work, an improved flow pattern map and flow boiling model were developed, which resulted in a substantial progress in the accurate predict of heat transfer in plain, horizontal tubes for refrigerants without oil. The Kattan et al. correlation was programmed to calculate and compare predicted heat transfer coefficients to the new HFC 407C test data. The flow pattern map proposed by Kattan et al. was also programmed and compared to flow regimes observed for HFC 407C. It predicted the HFC 407C flow pattern data quite accurately. The original objective of the HFC 407C measurements was the validation of the Kattan et al. correlation applied to a zeotropic refrigerant blend. Local flow boiling heat transfer coefficients were measured for HFC 407C evaporating inside a microfin and a plain tube. In addition, microfin heat transfer augmentation relative to a plain tube was investigated. The presence of oil in the evaporator had a complex effect on heat transfer coefficients. Local flow boiling heat transfer coefficients were measured for refrigerant HFC 407C ester oil mixtures (Mobil EAL Arctic 68). A new thermodynamic approach for modeling mixtures of zeotropic refrigerant blends and lubricating oils was also developed. (author) figs., tabs., 14 refs.

Duodenal atresia in an infant with triple-X syndrome: a new associated malformation in 47,XXX.

Science.gov (United States)

Rolle, Udo; Linse, Barbara; Glasow, Simone; Sandig, Klaus Rainer; Richter, Thomas; Till, Holger

2007-08-01

An association between the triple-X syndrome (47,XXX) and gastrointestinal malformations is extremely rare. Most 47,XXX patients present with a normal phenotype, but genitourinary malformations have been described. We report a case of a child with 47,XXX and duodenal atresia. Antenatal ultrasound scan showed a dilated fetal stomach and upper part of the duodenum (double bubble phenomenon) at 31 weeks of gestation in a 31-year-old woman with polyhydramnion. The amniotic fluid karyotype showed 47,XXX. After a scheduled delivery, duodenal atresia was confirmed and treated with duodeno-duodenostomy. The possible association of gastrointestinal and genitourinary tract anomalies requires a detailed postnatal clinical investigation and ultrasonographic examination of the abdomen, retroperitoneum, and pelvis on all triple-X syndrome patients. 2007 Wiley-Liss, Inc.

Pattern of dental development in Hominid XVIII from the Middle Pleistocene Atapuerca-Sima de los Huesos site (Spain).

Science.gov (United States)

Bermudez De Castro, J M; Rosas, A

2001-04-01

. We describe the pattern of dental development of Hominid XVIII from the Middle Pleistocene Sima de los Huesos (SH) site of the Sierra de Atapuerca (Burgos, Spain). As expected, this pattern is similar to that of modern humans. A delay of development of the lower and upper canines was observed. In contrast, the relative advanced development of the lower second molars and, especially, the upper and lower third molars is noteworthy. This latter feature seems to be common in Pleistocene hominids, and suggests that the pattern of dental development evolved in the genus Homo during the Pleistocene. In European Middle Pleistocene hominids, this pattern probably was facilitated by the extra space available in the mandible and maxilla for developing teeth. Copyright 2001 Wiley-Liss, Inc.

Risk factors for sexual aggression in young men: an expansion of the confluence model.

Science.gov (United States)

Abbey, Antonia; Jacques-Tiura, Angela J; LeBreton, James M

2011-01-01

There are many explanations for high rates of sexual aggression, with no one theory dominating the field. This study extends past research by evaluating an expanded version of the confluence model with a community sample. One-hour audio computer-assisted self-interviews were completed by 470 young single men. Using structural equation analyses, delinquency, hostile masculinity, impersonal sex, and misperception of women's sexual cues were positively and directly associated with the number of sexually aggressive acts committed. There were also indirect effects of childhood victimization, personality traits associated with subclinical levels of psychopathy, and alcohol consumption. These findings demonstrate the usefulness of the confluence model, as well as the importance of broadening this theory to include additional constructs. © 2011 Wiley-Liss, Inc.

The Jovian ring was imaged at 2.26+/-0.03 microns at approximately 7:00 UT on 12 July, 1994, from NA

Science.gov (United States)

2002-01-01

The Jovian ring was imaged at 2.26+/-0.03 microns at approximately 7:00 UT on 12 July, 1994, from NASA's Infrared Telescope Facility. The image was coadded from three 30-second exposures with sky subtracted. The resolution was 0.31 arcseconds per pixel. A S/N 5 per pixel was obtained for the coadded images. Photometry on the ring image is pending. This is part of a program to monitor the effects of the dust from Comet Shoemaker-Levy 9 on the Jovian ring system. More images will be taken during and after the impacts of the fragments. The image was obtained by Philip Esterle (University of Maryland), Casey Lisse (NASA/Goddard Space Flight Center), and Mark Shure (University of Hawaii).

The role of entrepreneurial activities in academic pharmaceutical science research.

Science.gov (United States)

Stinchcomb, Audra L

2010-06-01

Academic pharmaceutical science research is expanding further and further from the University setting to encompass the for-profit private company setting. This parallels the National Institutes of Health momentum to include multiple funding opportunities for University and private company collaboration. It has been recognized that the nonprofit and for-profit combination research model can accelerate the commercialization of pharmaceutical products, and therefore more efficiently improve human health. Entrepreneurial activities require unique considerations in the University environment, but can be modeled after the commercialization expansion of the academic healthcare enterprise. Challenges and barriers exist to starting a company as an entrepreneurial faculty member, but the rewards to one's personal and professional lives are incomparable. (c) 2009 Wiley-Liss, Inc. and the American Pharmacists Association

Ground use by northern muriquis (Brachyteles hypoxanthus).

Science.gov (United States)

Mourthé, Italo M C; Guedes, Danusa; Fidelis, Janaína; Boubli, Jean P; Mendes, Sérgio L; Strier, Karen B

2007-06-01

Many arboreal primates descend to the ground, a custom that may occur more frequently in disturbed habitats, and in the presence of researchers to whom the primates are habituated. In this paper, we describe opportunistic observations of ground use in two groups of northern muriquis (Brachyteles hypoxanthus) at the RPPN Feliciano Miguel Abdala, Minas Gerais, Brazil. Members of both groups were observed drinking, resting, feeding, playing, and traveling on the ground to different degrees, and variation in the levels of habituation of the two groups may be responsible for the differences in the distribution of their terrestrial activities. The potential increase in vulnerability to predation or disease owing to ground use has implications for the conservation of this critically endangered species. (c) 2007 Wiley-Liss, Inc.

Mutational analysis of the Wolfram syndrome gene in two families with chromosome 4p-linked bipolar affective disorder.

Science.gov (United States)

Evans, K L; Lawson, D; Meitinger, T; Blackwood, D H; Porteous, D J

2000-04-03

Bipolar affective disorder (BPAD) is a complex disease with a significant genetic component. Heterozygous carriers of Wolfram syndrome (WFS) are at increased risk of psychiatric illness. A gene for WFS (WFS1) has recently been cloned and mapped to chromosome 4p, in the general region we previously reported as showing linkage to BPAD. Here we present sequence analysis of the WFS1 coding sequence in five affected individuals from two chromosome 4p-linked families. This resulted in the identification of six polymorphisms, two of which are predicted to change the amino acid sequence of the WFS1 protein, however none of the changes segregated with disease status. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:158-160, 2000. Copyright 2000 Wiley-Liss, Inc.

Dystrophic microglia in the aging human brain.

Science.gov (United States)

Streit, Wolfgang J; Sammons, Nicole W; Kuhns, Amanda J; Sparks, D Larry

2004-01-15

We have studied microglial morphology in the human cerebral cortex of two nondemented subjects using high-resolution LN-3 immunohistochemistry. Several abnormalities in microglial cytoplasmic structure, including deramification, spheroid formation, gnarling, and fragmentation of processes, were identified. These changes were determined to be different from the morphological changes that occur during microglial activation and they were designated collectively as microglial dystrophy. Quantitative evaluation of dystrophic changes in microglia revealed that these were much more prevalent in the older subject (68-year-old) than in the younger one (38-year-old). Thus, we conclude that microglial dystrophy is a sign of microglial cell senescence. We hypothesize that microglial senescence could be important for understanding age-related declines in cognitive function. Copyright 2003 Wiley-Liss, Inc.

Longer you play, the more hostile you feel: examination of first person shooter video games and aggression during video game play.

Science.gov (United States)

Barlett, Christopher P; Harris, Richard J; Baldassaro, Ross

2007-01-01

This study investigated the effects of video game play on aggression. Using the General Aggression Model, as applied to video games by Anderson and Bushman, [2002] this study measured physiological arousal, state hostility, and how aggressively participants would respond to three hypothetical scenarios. In addition, this study measured each of these variables multiple times to gauge how aggression would change with increased video game play. Results showed a significant increase from baseline in hostility and aggression (based on two of the three story stems), which is consistent with the General Aggression Model. This study adds to the existing literature on video games and aggression by showing that increased play of a violent first person shooter video game can significantly increase aggression from baseline. 2007 Wiley-Liss, Inc.

Vitreous humor and albumin augment the proliferation of cultured retinal precursor cells

DEFF Research Database (Denmark)

Yang, Jing; Klassen, Henry; Pries, Mette

2008-01-01

concentrations of vitreous fluid supplementation was quantified by using a (3)H-thymidine incorporation assay. Active components of vitreous fluid were partially characterized by gel filtration chromatography (GFC) and UV spectral analysis. The effect of each vitreous fraction on proliferation was determined...... Da, consistent with ascorbic acid. Ascorbic acid was confirmed in vitreous fluid by UV spectral analysis. Growth-augmenting activity was present in higher molecular mass vitreous fractions, consistent with protein components. Albumin, the major protein in vitreous fluid, was found to augment...... proliferation. Because vitreous-associated augmentation of retinal precursor proliferation remains an epidermal growth factor-dependent phenomenon, the proliferative status of transplanted cells in the vitreous cavity is likely determined by a combination of factors. (c) 2008 Wiley-Liss, Inc....

Symmetry of priapulids (Priapulida). 1. Symmetry of adults.

Science.gov (United States)

Adrianov, A V; Malakhov, V V

2001-02-01

Priapulids possess a radial symmetry that is remarkably reflected in both external morphology and internal anatomy. It results in the appearance of 25-radial (a number divisible by five) symmetry summarized as a combination of nonaradial, octaradial, and octaradial (9+8+8) symmetries of scalids. The radial symmetry is a secondary appearance considered as an evolutionary adaptation to a lifestyle within the three-dimensional environment of bottom sediment. The eight anteriormost, or primary, scalids retain their particular position because of their innervation directly from the circumpharyngeal brain. As a result of a combination of the octaradial symmetry of primary scalids, pentaradial symmetry of teeth, and the 25-radial symmetry of scalids, the initial bilateral symmetry remains characterized by the single sagittal plane. Copyright 2001 Wiley-Liss, Inc.

Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics.

Science.gov (United States)

Cardno, A G; Gottesman, I I

2000-01-01

Twin studies have been vital for establishing an important genetic contribution to the etiology of schizophrenia. The five newest studies since 1995 from Europe and Japan have confirmed earlier findings. They yielded probandwise concordance rates of 41-65% in monozygotic (MZ) pairs and 0-28% in dizygotic (DZ) pairs, and heritability estimates of approximately 80-85%. Twin studies are also valuable for investigating the etiological relationships between schizophrenia and other disorders, and the genetic basis of clinical heterogeneity within schizophrenia. Studies of discordant MZ pairs provide further insights into non-inherited factors that contribute to the multifactorial etiology of this disorder. More recently, twin studies have begun to be used to directly investigate molecular genetic and epigenetic processes underlying schizophrenia. Copyright 2000 Wiley-Liss, Inc.

A colorimetric chiral sensor based on chiral crown ether for the recognition of the two enantiomers of primary amino alcohols and amines.

Science.gov (United States)

Cho, Eun Na Rae; Li, Yinan; Kim, Hee Jin; Hyun, Myung Ho

2011-04-01

A new colorimetric chiral sensor material consisting of three different functional sites such as chromophore (2,4-dinitrophenylazophenol dye), binding site (crown ether), and chiral barrier (3,3'-diphenyl-1,1'-binaphthyl group) was prepared and applied to the recognition of the two enantiomers of primary amino alcohols and amines. Among five primary amino alcohols and two primary amines tested, the two enantiomers of phenylalaninol show the highest difference in the absorption maximum wavelength (Δλ(max)=43.5 nm) and in the association constants (K(S)/K(R)=2.51) upon complexation with the colorimetric chiral sensor material and, consequently, the two enantiomers of phenylalaninol were clearly distinguished from each other by the color difference. Copyright © 2010 Wiley-Liss, Inc.

The use of brainstorming for teaching human anatomy.

Science.gov (United States)

Geuna, S; Giacobini-Robecchi, M G

2002-10-15

Interactive teaching techniques have been used mainly in clinical teaching, with little attention given to their use in basic science teaching. With the aim of partially filling this gap, this study outlines an interactive approach to teaching anatomy based on the use of "brainstorming." The results of the students' critique of the teaching techniques are also included. Seventy-five students from the first-year nursing curriculum were tested by a structured questionnaire after three brainstorming sessions. The overall response to these sessions was very positive, indicating that students perceived this interactive technique as both interesting and useful. Furthermore, this approach may provide a useful strategy when learning the clinical courses of the upcoming academic years. Copyright 2002 Wiley-Liss, Inc.

Calorimetric, FTIR and 1H NMR measurements in combination with DFT calculations for monitoring solid-state changes of dynamics of sibutramine hydrochloride.

Science.gov (United States)

Pajzderska, Aleksandra; Chudoba, Dorota M; Mielcarek, Jadwiga; Wąsicki, Jan

2012-10-01

Two forms of sibutramine hydrochloride, monohydrate and anhydrous, have been investigated by calorimetric methods, Fourier transform infrared (FTIR) absorption and (1) H nuclear magnetic resonance (NMR) measurements as well as by density functional theory (DFT) of vibrational frequencies and infrared intensities, calculations of steric hindrances and Monte Carlo simulations. The results of FTIR spectra combined with DFT calculations permitted identification of the bands corresponding to the dynamics and vibrations of water molecules. NMR study and Monte Carlo simulations revealed the occurrence of reorientation jumps of the methyl groups in sibutramine cation and also revealed that the reorientation of isopropyl group is possible only in sibutramine monohydrate hydrochloride. The hydration of sibutramine hydrochloride causes a change in the conformation of sibutramine cation. Copyright © 2012 Wiley-Liss, Inc.

Captive-rearing piping plovers: Developing techniques to augment wild populations

Science.gov (United States)

Powell, A.N.; Cuthbert, F.J.; Wemmer, L.C.; Doolittle, A.W.; Feirer, S.T.

1997-01-01

Techniques for captive-rearing and releasing piping plovers (Charadrius melodus) were developed using a surrogate species, killdeer (Charadrius vociferus). We compared captive-and parent-reared killdeer, and parent-reared piping plovers and determined that growth and behavior were similar. After surrogate trials determined that captive-rearing was feasible, we used the same methods to raise piping plover chicks from salvaged eggs. For captive-reared chick of both species, survival to fledging was higher than and behaviors similar to parent-reared chicks in the wild. Rearing techniques were fine-tuned, and ten piping plover fledglings were released to the wild. Based on our results, we developed recommendations for captive-rearing piping plovers using salvaged eggs to enhance productivity of small populations. ?? 1997 Wiley-Liss, Inc.

A quantitative measure of chirality inside nucleic acid databank.

Science.gov (United States)

Pietropaolo, Adriana; Parrinello, Michele

2011-08-01

We show the capability of a chirality index (Pietropaolo et al., Proteins 2008;70:667-677) to investigate nucleic acid structures because of its high sensitivity to helical conformations. By analyzing selected structures of DNA and RNA, we have found that sequences rich in cytosine and guanine have a tendency to left-handed chirality, in contrast to regions rich in adenine or thymine which show strong negative, right-handed, chirality values. We also analyze RNA structures, where specific loops and hairpin motifs are characterized by a well-defined chirality value. We find that in nucleosome the chirality is exalted, whereas in ribosome it is reduced. Our results illustrate the sensitivity of this descriptor for nucleic acid conformations. Copyright © 2011 Wiley-Liss, Inc.

Individualism, collectivism, and Chinese adolescents' aggression: intracultural variations.

Science.gov (United States)

Li, Yan; Wang, Mo; Wang, Cixin; Shi, Junqi

2010-01-01

This study examined the relations between cultural values (i.e., individualism and collectivism) and aggression among 460 (234 girls) Chinese adolescents. Conflict level and social status insecurity were examined as potential explaining mechanisms for these relations. The results showed that adolescents' endorsement of collectivism was negatively related to their use of overt and relational aggression as reported by teachers and peers, whereas positive associations were found between the endorsement of individualism and adolescent aggression. Adolescents' conflict level and social status insecurity accounted for a significant part of these associations. Findings of this study demonstrate the importance of examining intracultural variations of cultural values in relation to adolescent aggression as well as the process variables in explaining the relations. (c) 2010 Wiley-Liss, Inc.

Painful procedures in children with cancer: comparison of moderate sedation and general anesthesia for lumbar puncture and bone marrow aspiration.

Science.gov (United States)

Iannalfi, Alberto; Bernini, Gabriella; Caprilli, Simona; Lippi, Alma; Tucci, Fabio; Messeri, Andrea

2005-12-01

The study was conducted to compare moderate sedation (MS) with general anesthesia (GA) in the management of frequently performed lumbar puncture or bone marrow aspiration (BMA) during the treatment of childhood cancer. The MS (14 patients for 30 procedures) was managed by non-anesthesiologists (combined nitrous oxide-midazolam +/- non-pharmacological techniques). The GA was managed by anesthesiologists (17 patients for 30 procedures). A neutral observer recorded side effects, use of sedative antagonists, recovery time, oncologist's evaluation, procedure behaviors check list (PBCL); subjective perceptions during the procedure with a questionnaire administered to children (>6 years) and their parents; drugs costs and professional resources. P-values compliance and cost-effectiveness as it relies on the contribution of non-pharmacological techniques. 2005 Wiley-Liss, Inc.

Pulmonary response to surface‐coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: A toxicogenomic study

DEFF Research Database (Denmark)

Halappanavar, Sabina; Jackson, Petra; Williams, Andrew

2011-01-01

with acute phase, inflammation and immune response 5 days post exposure with concomitant changes in several miRNAs. The role of these miRNAs in pulmonary response to inhaled particles is unknown and warrants further research. Environ. Mol. Mutagen., 2011. © 2011 Wiley‐Liss, Inc....... in increased levels of mRNA for acute phase markers serum amyloid A‐1 (Saa1) and serum amyloid A‐3 (Saa3), several C‐X‐C and C‐C motif chemokines, and cytokine tumor necrosis factor genes. Protein analysis of Saa1 and 3 showed selective upregulation of Saa3 in lung tissues. Sixteen miRNAs were induced by more...... than 1.2‐fold (adjusted P‐value changes in the expression of genes associated...

Neglecting safety precautions may lead to trenching fatalities.

Science.gov (United States)

Deatherage, J Harold; Furches, Lisa K; Radcliffe, Mike; Schriver, William R; Wagner, John P

2004-06-01

Trench collapses ranked as the seventh leading cause of the possible twenty-nine causes of OSHA-inspected fatal construction events during the period 1991-2001. This study aims to examine why these fatalities occurred. Forty-four case files from OSHA inspections of fatal trench collapses were reviewed. Improper protection of the excavation site where work was taking place was the leading fatality cause. Several organizational or physical conditions were present at many fatal sites; the most frequent was that no training had been provided for trenching. Presence of a competent, diligent person at the site would have prohibited most fatalities. The top cited violation was lack of protection, that is, benching, shoring, sloping, trench boxes, etc. (29 CFR 1926.652 (a) (1)). Copyright 2004 Wiley-Liss, Inc.

Carcass analysis to improve a meat-based diet for the artificial rearing of the predatory mirid bug Dicyphus tamaninii.

Science.gov (United States)

Zapata, Rafael; Specty, Olivier; Grenier, Simon; Febvay, Gérard; Pageaux, Jean François; Delobel, Bernard; Castañé, Cristina

2005-10-01

Improvement of an existing meat-based diet has been obtained for rearing the generalist predator Dicyphus tamaninii (Heteroptera: Miridae). The approach followed, different from the classical addition/deletion method, was performing biochemical analysis of adult carcasses in order to have information about the nutritional status of the predator. Comparison of total, free amino acids and lipid composition of meat-reared and conventionally reared females allowed detecting some nutritional deficiencies. A reformulated diet with new sources of proteins and lipids was tested again with the predator. Some biological parameters of bugs that were inferior in the initial meat diet when compared with those of the conventionally reared insects, such as nymphal development time and fresh weight, have been improved with the reformulated diet. (c) 2005 Wiley-Liss, Inc.

One century of studies on lead poisoning in papers published in La Medicina del Lavoro.

Science.gov (United States)

Alessio, L; Cortesi, I; Materzanini, P; Barenghi, M

2000-09-01

One century of papers published in the Italian journal of occupational medicine, La Medicina del Lavoro, shows clearly that the study of lead is an exemplary topic for occupational physicians, enabling them to observe the evolution of research in the field of occupational health. The numerous pathological features of lead poisoning, doctors' successive therapeutic responses, and their gradual development of preventive techniques, form a paradigm that has subsequently been applied to all other fields of industrial toxicology. The evolution of the study of lead poisoning during this century is a complete example in the field of occupational toxicology for medical students: it will stimulate them in applying both clinical and preventive knowledge in the field of industrial toxicology. Copyright 2000 Wiley-Liss, Inc.

A concise summary of experimental facts about the Soai reaction.

Science.gov (United States)

Gehring, Timo; Busch, Mark; Schlageter, Martin; Weingand, Daniel

2010-01-01

The Soai reaction amplifies small enantiomeric excesses in a spectacular manner. Being known for 20 years, it has drawn the attention of many scientists in different fields as it is to date the only chemical reaction offering the chance to study the phenomenon of asymmetric autocatalysis in conjunction with high amplification of enantiomeric excess (ee). This mini-review comprises an introduction to the discovery of asymmetric autocatalysis with amplification of ee and a concise summary of published experimental results showing which starting materials and reaction parameters play an important role in this reaction and which influences are understood. It is addressed especially to scientists entering the field of the Soai reaction to get a quick overview of important aspects. © 2010 Wiley-Liss, Inc.

Douleurs induites par les soins: la réalité au Centre Hospitalier Universitaire de Befelatanana Antananarivo, Madagascar

Science.gov (United States)

Mahavivola, Ernestho-Ghoud Indretsy; Olivah, Razanaparany Miarisoa Mireille; Mihary, Dodo; Hendriniaina, Rakotoharivelo; Lalao, Randriamboavonjy Rado; Henintsoa, Rakotonirainy Oliva; Fahafahantsoa, Rapelanoro Rabenja

2014-01-01

La douleur induite par les soins correspond à la douleur survenant lors des actes à visé diagnostique et/ou thérapeutique. A notre connaissance, nous n'avons pas encore des données disponibles pour les douleurs induites par les soins à l'Hôpital de Befelatanana. Nos objectifs étaient de décrire le profil épidémiologique de la douleur induite par les soins, d'identifier les principaux facteurs influençant sur l'intensité de la douleur et leurs retentissements chez les patients. Il s'agissait d'une étude rétrospective, transversale type un jour donné menée dans les douze services de Médecines au Centre Hospitalier Universitaire de Befelatanana en Novembre 2013. Cent deux patients ont été retenus dans l’étude et trois cent vingt trois actes douloureux étaient enregistrés. La fréquence de la douleur induite par les soins était de 69,86%. Le genre féminin prédominait dans 52% des cas (n = 53) avec un sex-ratio à 0,92. L’âge moyen était de 46 ans. Les ponctions vasculaires étaient l'acte prédominant dans 49,54% (n = 109) des cas. Les infirmiers réalisaient les soins dans 47,05% (n = 48) des cas. L'information verbale était la mesure préventive utilisée dans 57,84% des cas (n = 59). Le transport par marche à pied et au dos représentait 16,67% des cas (n = 17). Les patients naïfs des gestes étaient plus anxieux. Ces patients gardaient de mauvais souvenir dans 64,71% des cas (n = 66). La fréquence de douleur induite par les soins était trop élevée. Un effort important est nécessaire pour réduire la douleur induite par les soins PMID:25932071

The study of the digestive absorption of water in patients suffering from cirrhosis of the liver, by using two hydrogen tracers; etude de l'absorption digestive de l'eau chez les malades atteints de cirrhose du foie a l'aide de deux indicateurs de l'hydrogene

Energy Technology Data Exchange (ETDEWEB)

Laine-Boszormenyi, M. [Institut National d' Hygiene (France); Fallot, P.; Masson, J.; Calvet, P. [Commissariat a l' energie atomique et aux energies alternatives - CEA, Service de, CEA Saclay (France)

1960-07-01

We have studied the rate of appearance of ingested water in the peripheral blood of four patients suffering from cirrhosis of the liver with ascites. For this purpose, oral administration of deuterium oxide and intravenous administration of tritiated water were made simultaneously. This double experiment enables the phenomenon of diffusion of the tracer outside the vascular regions to be observed and calculation to be made of the amounts absorbed by the digestive tract and transferred to the peripheral circulation. The rate of absorption observed under the above conditions proves to be distinctly less (1.2 percent per minute of the ingested dose) than that observed by Scholer and Code in normal subjects (9 percent per minute of the ingested dose). Hypotheses are advanced which could account for the facts observed and which offer a satisfactory explanation of Gilbert's opsiuria. Reprint of a paper published in International Journal of Applied Radiation and Isotopes, vol. 7, p. 233-243, 1960 [French] Nous avons etudie chez quatre malades atteints de cirrhose du foie avec ascite, la vitesse d'apparition dans le sang peripherique de l'eau ingeree. A cet effet, nous avons administre simultanement a nos malades de l'oxyde de deuterium par voie orale et de l'eau tritiee par voie intraveineuse. Cette double epreuve permet de faire la part du phenomene de diffusion de 11 indicateur hors des territoires vasculaires et de calculer les quantites absorbees par le tube digestif et transferees dans la circulation peripherique. La vitesse d'absorption appreciee dans les conditions precedentes (1,2 pour cent par minute de la dose ingeree) s'avere notablement inferieure a celle observee par SCHOLER et CODE chez les sujets normaux (9 pour cent par minute de la dose ingeree). Nous avons evoque des hypotheses susceptibles de rendre compte des faits observes qui apportent une explication satisfaisante a l'opsiurie de Gilbert. Reproduction d'un article publie dans International Journal

The Accelerating Spin Of 9P/Tempel 1

Science.gov (United States)

Belton, Michael J.; Drahus, M.

2007-10-01

Deep Impact approach photometry has been analyzed using the dynamical techniques introduced by Drahus and Waniak (2006). Clear indications of acceleration (0.70 +/- 0.24 x 10-7 h-2) in the spin rate are found together with a spin period of 40.850 +/- 0.017 h at the mid point of the data set (June 2.38304, 2005 UT). This measurement of acceleration in the spin is similar to that deduced independently from a combination of spin rate measurements derived from the Deep Impact Earth-based campaign (Meech et al. 2005), Spitzer observations (Lisse et al. 2005), and Deep Impact approach data (A'Hearn et al. 2005). Estimates of the spin rate from these sources (Belton et al. 2007) at epochs between 1999 and 2006 were coupled through the 2005 perihelion passage using a heuristic spin rate change model based on non-gravitational torques due to the outflow of H2O. This model yields a preliminary estimate of 1.15×10-7 h-2 for the acceleration of the spin at the mid point of the data set; it also suggests that the net torque is dominated by activity in the Northern hemisphere of the nucleus. Although non-constant periodicities have been reported for a few comets before, the evidence has never been detected as clearly and unambiguously as for 9P/Tempel 1. This discovery strongly impacts the preparations for the Stardust-NExT mission (http://stardust.jpl.nasa.gov/news/status/070703.html) scheduled to arrive at the comet in 2011. References: A'Hearn, M.F. and 32 colleagues, 2005. Science 310, 258-264. Belton, M.J.S. and 35 colleagues, 2007. In preparation. Drahus, M, and Waniak, W. 2006, Icarus 185, 544 Lisse, C.M and 8 colleagues 2005. Astrophys. J. 625, L139-L142. Meech, K.J. and 208 colleagues, 2005. Science 310, 265-269.

Young Debris Disks With Newly Discovered Emission Features

Science.gov (United States)

Ballering, N.

2014-04-01

We analyzed the Spitzer/IRS spectra of young A and F stars that host debris disks with previously unidentified silicate emission features. Such features probe small, warm dust grains in the inner regions of these young systems where terrestrial planet formation may be proceeding (Lisse et al. 2009). For most systems, these regions are too near their host star to be directly seen with high-contrast imaging and too warm to be imaged with submillimeter interferometers. Mid-infrared excess spectra - originating from the thermal emission of the debris disk dust - remain the best data to constrain the properties of the debris in these regions. For each target, we fit physically-motivated model spectra to the data. Typical spectra of unresolved debris disks are featureless and suffer severe degeneracies between the dust location and the grain properties; however, spectra with solid-state emission features provide significantly more information, allowing for a more accurate determination of the dust size, composition, and location (e.g. Chen et al. 2006; Olofsson et al. 2012). Our results shed light on the dynamic properties occurring in the terrestrial regions of these systems. For instance, the sizes of the smallest grains and the nature of the grain size distribution reveal whether the dust originates from steady-state collisional cascades or from stochastic collisions. The properties of the dust grains - such as their crystalline or amorphous structure - can inform us of grain processing mechanisms in the disk. The location of this debris illuminates where terrestrial planet forming activity is occurring. We used results from the Beta Pictoris - which has a well-resolved debris disk with emission features (Li et al. 2012) - to place our results in context. References: Chen et al. 2006, ApJS, 166, 351 Li et al. 2012, ApJ, 759, 81 Lisse et al. 2009, ApJ, 701, 2019 Olofsson et al. 2012, A&A, 542, A90

Idées nouvelles concernant la variable critique de Leloup. Utilisation de cette variable dans le cas des graisses et dans le cas de l'eau New Ldeas About the Leloup Critical Variable. Use of This Variable for Lubricants and Water

Directory of Open Access Journals (Sweden)

Bozet J.

2006-11-01

Full Text Available Cet article est essentiellement consacré au fonctionnement. d'un palier lisse en conditions limites, les films édifiés à l'interface étant trop minces pour éviter les interactions de surface. L'auteur montre tout d'abord la relation qui existe entre la variable de Leloup, utilisée par un grand nombre de praticiens, et les caractéristiques du film élasto-hydrodynamique qui se développe aux environs du point critique. Il étudie ensuite le comportement de coussinets graphités lubrifiés à l'eau ; il introduit enfin la lubrification à la graisse de paliers lisses classiques. L'analyse des résultats obtenus au laboratoire permet de conclure à la validité de la variable L pour les deux fluides utilisés. A l'issue de son travail, l'auteur indique que la localisation du point critique relevé expérimentalement dans le cas d'une lubrification à la graisse dépend essentiellement des caractéristiques de l'huile de base, le savon ne jouant qu'un rôle très secondaire. This article mainly deals with the boundary lubrication of journal bearings in which the films at the interfaces are too thin to prevent surface friction. The article first describes the relation existing between the Leloup variable used by a great many technicians and the properties of the elastohydrodynamic film created in the area around the critical point. It then examines the behavior of water-lubricated graphite bearings before going on to the lubrication of conventional journal bearings with grease. An analysis of laboratory results leads to the conclusion that the L variable is valid for both types of fluids. The article concludes by situating the critical point determined experimentally on bearings lubricated with grease. The location of this critical point depends mainly on the properfies of the base oil, in which soap plays only a very secondary role.

Annual cycle of sperm storage in spermathecae of the red-spotted newt, Notophthalmus viridescens (Amphibia: Salamandridae).

Science.gov (United States)

Sever, David M; Rania, Lisa C; Krenz, John D

1996-02-01

Female sperm storage was studied in a population of Notophthalmus viridescens from South Carolina. Spermathecae initiate production of a glycoprotein secretory product in October. At this time ovarian follicles are immature (0.5-0.9 mm dia), and mating does not occur despite spermiation in males. Six of the 10 females collected in December had sperm in their spermathecae, indicating onset of mating. Unmated females collected in October and sacrificed in February and March possessed mature ovarian follicles (1.3-1.4 mm dia), and the spermathecae contained large secretory vacuoles 2-3 μm dia. Release of secretory product is concomitant with the appearance of sperm in the spermathecae. Thus mated females lack secretory vacuoles in the spermathecal epithelium, and additional synthesis of secretory product does not occur. All females collected in February and March have mated. Sperm are embedded in the spermathecal epithelium and are undergoing degradation in February. Degradation of sperm in the lumen and epithelium is evident in specimens examined from May and June. Atresia of ovarian follicles begins in April in captive specimens, and specimens captured from the bay in May are spent. A general postbreeding emigration from the pond occurs in summer. Fourteen females collected 7 March were injected with human chorionic gonadotropin (hCG) on 9 March and laid fertile eggs 10-18 March. Two of these females were sacrificed each month from April-September; all retained some sperm in their spermathecae, but further oviposition did not occur. Four females were kept 1 year after oviposition of fertile eggs, and oviposition again was induced with hCG; these eggs were infertile, and spermathecae lacked sperm. Spermathecae are inactive from June-September in captive and wild-caught specimens. Sperm may be stored effectively up to 6 months (December-May), and no evidence was found for retention of viable sperm from one breeding season to the next. © 1996 Wiley-Liss, Inc

Unfolding energetics and stability of banana lectin.

Science.gov (United States)

Gupta, Garima; Sinha, Sharmistha; Surolia, Avadhesha

2008-08-01

The unfolding pathway of banana lectin from Musa paradisiaca was determined by isothermal denaturation induced by the chaotrope GdnCl. The unfolding was found to be a reversible process. The data obtained by isothermal denaturation provided information on conformational stability of banana lectin. The high values of DeltaG of unfolding at various temperatures indicated the strength of intersubunit interactions. It was found that banana lectin is a very stable and denatures at high chaotrope concentrations only. The basis of the stability may be attributed to strong hydrogen bonds of the order 2.5-3.1 A at the dimeric interface along with the presence of water bridges. This is perhaps very unique example in proteins where subunit association is not a consequence of the predominance of hydrophobic interactions. (c) 2008 Wiley-Liss, Inc.

Genetic structure of seven Mexican indigenous populations based on five polymarker loci.

Science.gov (United States)

Buentello-Malo, Leonora; Peñaloza-Espinosa, Rosenda I; Loeza, Francisco; Salamanca-Gomez, Fabio; Cerda-Flores, Ricardo M

2003-01-01

This descriptive study investigates the genetic structure of seven Mexican indigenous populations (Mixteca Alta, Mixteca Baja, Otomies, Purepecha, Nahuas-Guerrero, Nahuas-Xochimilco, and Tzeltales) on the basis of five PCR-based polymorphic DNA loci: LDLR, GYPA, HBGG, D7S8, and GC. Genetic distance and diversity analyses indicate that these Mexican indigenous are similar and that more than 96% of the total gene diversity (H(T)) can be attributed to individual variation within populations. Mixteca-Alta, Mixteca-Baja, and Nahuas-Xochimilco show indications of higher admixture with European-derived persons. The demonstration of a relative genetic homogeneity of Mexican Indians for the markers studied suggests that this population is suitable for studying disease-marker associations in the search for candidate genes of complex diseases. Copyright 2002 Wiley-Liss, Inc.

The peacock's train (Pavo cristatus and Pavo cristatus mut. alba) I. structure, mechanics, and chemistry of the tail feather coverts.

Science.gov (United States)

Weiss, Ingrid M; Kirchner, Helmut O K

2010-12-01

The feathers in the train of the peacock serve not for flying but for sexual display. They are long, slender beams loaded in bending by their own weight. An outer circular conical shell, the cortex, is filled by a closed foam of 7.6% relative density, the medulla, both of feather keratin. Outer diameter and thickness of the cortex decrease linearly from the body toward the tip. This self-similar geometry leads to a division of labor. The cortex (longitudinal Young's modulus 3.3 GPa, transverse modulus 1 GPa) provides 96% of the longitudinal strength and bending rigidity of the feather. The medulla (Young's modulus 10 MPa) provides 96% of the transverse compressive rigidity. Fracture stress of the cortex, both longitudinal and transverse, is 120 MPa. Copyright © 2010 Wiley-Liss, Inc., A Wiley Company.

Antigenotoxic effects of Citrus aurentium L. fruit peel oil on mutagenicity of two alkylating agents and two metals in the Drosophila wing spot test.

Science.gov (United States)

Demir, Eşref; Kocaoğlu, Serap; Cetin, Huseyin; Kaya, Bülent

2009-07-01

Antigenotoxic effects of Citrus aurentium L. (Rutaceae) fruit peel oil (CPO) in combination with mutagenic metals and alkylating agents were studied using the wing spot test of D. melanogaster. The four reference mutagens, potassium dichromate (K2Cr2O7), cobalt chloride (CoCl2), ethylmethanesulfonate (EMS), and N-ethyl-N-nitrosourea (ENU) were clearly genotoxic. CPO alone at doses from 0.1 to 0.5% in Tween 80 was not mutagenic and did not enhance the mutagenic effect of the reference mutagens. However, antigenotoxic effects of CPO were clearly demonstrated in chronic cotreatments with mutagens and oil, by a significant decrease in wing spots induced by all four mutagens. The D. melanogaster wing spot test was found to be a suitable assay for detecting antigenotoxic effects in vivo. Copyright 2009 Wiley-Liss, Inc.

Comparison of fMRI and PEPSI during language processing in children.

Science.gov (United States)

Serafini, S; Steury, K; Richards, T; Corina, D; Abbott, R; Dager, S R; Berninger, V

2001-02-01

The present study explored the correlation between lactate as detected by MR spectroscopy (MRS) and blood oxygenation level dependent (BOLD) responses in male children during auditory-based language tasks. All subjects (N = 8) participated in one proton echo planar spectroscopic imaging (PEPSI) and one functional magnetic resonance imaging (fMRI) session that required phonological and lexical judgments to aurally presented stimuli. Valid PEPSI data was limited in the frontal areas of the brain due to the magnetic susceptibility of the eye orbits and frontal sinuses. Findings from the remainder of the brain indicate that subjects show a significant consistency across imaging techniques in the left temporal area during the lexical task, but not in any other measurable area or during the phonological task. Magn Reson Med 45:217-225, 2001. Copyright 2001 Wiley-Liss, Inc.

Encephalopathy and bilateral cataract in a boy with an interstitial deletion of Xp22 comprising the CDKL5 and NHS genes.

Science.gov (United States)

Van Esch, Hilde; Jansen, Anna; Bauters, Marijke; Froyen, Guy; Fryns, Jean-Pierre

2007-02-15

We describe a male patient with a deletion at Xp22, detected by high resolution X-array CGH. The clinical phenotype present in this infant boy, consists of severe encephalopathy, congenital cataracts and tetralogy of Fallot and can be attributed to the deletion of the genes within the interval. Among these deleted genes are the gene for Nance-Horan syndrome and the cyclin-dependent kinase-like 5 gene (CDKL5), responsible for the early seizure variant of Rett syndrome. This is the first description of a male patient with a deletion of these genes, showing the involvement of CDKL5 in severe epileptic encephalopathy in males. Moreover it illustrates the added value of high resolution array-CGH in molecular diagnosis of mental retardation-multiple congenital anomaly cases. (c) 2007 Wiley-Liss, Inc.

Diprosopus: a unique case and review of the literature.

Science.gov (United States)

Wu, June; Staffenberg, David A; Mulliken, John B; Shanske, Alan L

2002-12-01

We present a case of partial facial duplication in a male infant. The clinical, radiological, and laboratory findings for this patient are described, followed by a review of the literature. Craniofacial duplication is a rare form of conjoined twinning and presents in a wide spectrum, from dicephalus to diprosopus to partial facial duplication. Many of these cases can be diagnosed prenatally. Prenatal assessment of our patient revealed only agenesis of the corpus callosum. The pathogenesis is believed to involve duplication of the notochord. Where there are more severe associated anomalies, the prognosis is poor. Partial facial duplication, as in our case, is associated with fewer anomalies, and the prognosis is better. Symmetry and an excess of tissue, rather than deficiency, favor a positive result. Copyright 2002 Wiley-Liss, Inc.

How many species of woolly monkeys inhabit Colombian forests?

Science.gov (United States)

Botero, Sergio; Rengifo, Laura Y; Bueno, Marta L; Stevenson, Pablo R

2010-12-01

There is a controversy regarding how many species the genus Lagothrix contains, since the Lagothrix lagothricha subspecies have been recently proposed to be actual species. Clarification of species status is of particular importance in the case of L. l. lugens, because it is the most endangered and its distribution is restricted to the Colombian Andes, a highly deforested region. Using cytogenetic and molecular markers, we obtained evidence indicating that the subspecies status is appropriate for the two taxa occurring in this country. We also report high levels of intraspecific variability in the karyotype. We find evidence for a late Pleistocene separation of the subspecies, and we propose it is the limited area of contact between the taxa that allowed for them to partially differentiate. © 2010 Wiley-Liss, Inc.

Effects of realism on extended violent and nonviolent video game play on aggressive thoughts, feelings, and physiological arousal.

Science.gov (United States)

Barlett, Christopher P; Rodeheffer, Christopher

2009-01-01

Previous research has shown that playing violent video game exposure can increase aggressive thoughts, aggressive feelings, and physiological arousal. This study compared the effects that playing a realistic violent, unrealistic violent, or nonviolent video game for 45 min has on such variables. For the purpose of this study, realism was defined as the probability of seeing an event in real life. Participants (N=74; 39 male, 35 female) played either a realistic violent, unrealistic violent, or nonviolent video game for 45 min. Aggressive thoughts and aggressive feelings were measured four times (every 15 min), whereas arousal was measured continuously. The results showed that, though playing any violent game stimulated aggressive thoughts, playing a more realistic violent game stimulated significantly more aggressive feelings and arousal over the course of play. Copyright 2009 Wiley-Liss, Inc.

Genetic traces of east-to-west human expansion waves in Eurasia.

Science.gov (United States)

Chaix, Raphaëlle; Austerlitz, Frédéric; Hegay, Tatyana; Quintana-Murci, Lluís; Heyer, Evelyne

2008-07-01

In this study, we describe the landscape of human demographic expansions in Eurasia using a large continental Y chromosome and mitochondrial DNA dataset. Variation at these two uniparentally-inherited genetic systems retraces expansions that occurred in the past 60 ky, and shows a clear decrease of expansion ages from east to west Eurasia. To investigate the demographic events at the origin of this westward decrease of expansion ages, the estimated divergence ages between Eurasian populations are compared with the estimated expansion ages within each population. Both markers suggest that the demographic expansion diffused from east to west in Eurasia in a demic way, i.e., through migrations of individuals (and not just through diffusion of new technologies), highlighting the prominent role of eastern regions within Eurasia during Palaeolithic times. (c) 2008 Wiley-Liss, Inc.

Study on tooth development, past, present, and future.

Science.gov (United States)

Jung, Han-Sung; Hitoshi, Yamamoto; Kim, Hee-Jin

2003-04-01

For decades, the understanding of craniofacial development has been a central issue in odontology and developmental biology. As a consequence, a significant number of deformities are being studied for their variety of genotype and phenotype. Although there is little doubt about the essential roles of homeobox genes, transcription factors, and growth factors, we now know at least the fundamental strategy of craniofacial biology. The tooth as an organ performs a whole range of functions, each of which is truly indispensable for the maintenance of life. The possession of teeth is, therefore, obviously coupled with the complication of the natural structure of an individual organism. In the following, we shall focus on a brief history of tooth studies and some suggestions for obtaining a full understanding of teeth in the future. Copyright 2003 Wiley-Liss, Inc.

Perovskites in the comb roof base of hornets: their possible function.

Science.gov (United States)

Ishay, J S; Joseph, Z; Galushko, D; Ermakov, N; Bergman, D J; Barkay, Z; Stokroos, I; van der Want, J

2005-04-01

On the ceiling of the Oriental hornet comb cell, there are mineral granules of polycrystalline material known to belong to the group of perovskites. In a comb cell intended to house a worker hornet, the roof base usually carries one or several such perovskite granules containing titanium (Ti), whereas in the roof base of a cell housing a developing queen, there are usually several granules containing a high percentage of silicon (Si), aluminum (Al), calcium (Ca), and iron (Fe), but very little if any Ti. In worker comb cells, Ti usually appears as ilmenite (FeTiO3). Besides documenting the above-mentioned facts, this report discusses possible reasons for the appearance of ilmenite crystals in worker cells only and not in queen cells. (c) 2005 Wiley-Liss, Inc.

Contribution To The Data Warehouse And Prospects Of The IRS Program

Science.gov (United States)

Barner, Frithjof; Haydn, Rupert; Parmar, Manish; Makiola, Jens

2013-12-01

Over the past two years, the IRS program has again significantly contributed to the GSC-DA Data Warehouse. From its suite of optical EO satellites which operate in the visible, near IR and shortwave IR domain, multispectral data from the HR LISS-III and MR AWiFS sensors have been provided. Both cameras are implemented on board of Resourcesat-1 and Resourcesat-2 respectively. Despite reduced capacities, the Resourcesat constellation of satellites so far acquired cloud-free images of a vast majority of the first HR coverage of CORE_001 and several monthly MR coverages for CORE_008 over the EEA-39. The results regarding the above mentioned data sets will be discussed including an appraisal of the possible future role of upcoming IRS EO satellites for European data requirements.

Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats.

Science.gov (United States)

Ando, S; Tadenuma, T; Tanaka, Y; Fukui, F; Kobayashi, S; Ohashi, Y; Kawabata, T

2001-10-15

The effects of a carnitine derivative, acetyl-L-carnitine (ALCAR), on the cognitive and cholinergic activities of aging rats were examined. Rats were given ALCAR (100 mg/kg) per os for 3 months and were subjected to the Hebb-Williams tasks and a new maze task, AKON-1, to assess their learning capacity. The learning capacity of the ALCAR-treated group was superior to that of the control. Cholinergic activities were determined with synaptosomes isolated from the cortices. The high-affinity choline uptake by synaptosomes, acetylcholine synthesis in synaptosomes, and acetylcholine release from synaptosomes on membrane depolarization were all enhanced in the ALCAR group. This study indicates that chronic administration of ALCAR increases cholinergic synaptic transmission and consequently enhances learning capacity as a cognitive function in aging rats. Copyright 2001 Wiley-Liss, Inc.

Fibrinogen, homocyst(e)ine, and C-reactive protein concentrations relative to sex and socioeconomic status in British young people.

Science.gov (United States)

Thomas, Non-Eleri; Cooper, Stephen-Mark; Williams, Simon R P; Baker, Julien S; Davies, Bruce

2005-01-01

This study assesses the prevalence of recently identified coronary heart disease (CHD) risk factors in young people of differing socioeconomic status (SES). From November 2001 through March 2002, 100 boys and 108 girls, of age 12.9 +/- 0.3 years, selected from differing SES were assessed for CHD risk factors. Measurements included fibrinogen (Fg), homocyst(e)ine (Hcy), and C-reactive protein (CRP). Fibrinogen was significantly greater among boys from a higher SES compared with those from a low SES (P < or = 0.05). Differences according to sex (P < or = 0.05) were identified for Fg and CRP. The data indicate the prevalence of recently identified CHD risk factors in this cohort of British schoolchildren. For the purpose of this article, the phrase "young people" embraces both children and adolescents. Copyright 2005 Wiley-Liss, Inc

The role of cell cycle in retinal development: cyclin-dependent kinase inhibitors co-ordinate cell-cycle inhibition, cell-fate determination and differentiation in the developing retina.

Science.gov (United States)

Bilitou, Aikaterini; Ohnuma, Shin-ichi

2010-03-01

The mature retina is formed through multi-step developmental processes, including eye field specification, optic vesicle evagination, and cell-fate determination. Co-ordination of these developmental events with cell-proliferative activity is essential to achieve formation of proper retinal structure and function. In particular, the molecular and cellular dynamics of the final cell cycle significantly influence the identity that a cell acquires, since cell fate is largely determined at the final cell cycle for the production of postmitotic cells. This review summarizes our current understanding of the cellular mechanisms that underlie the co-ordination of cell-cycle and cell-fate determination, and also describes a molecular role of cyclin-dependent kinase inhibitors (CDKIs) as co-ordinators of cell-cycle arrest, cell-fate determination and differentiation. Copyright (c) 2010 Wiley-Liss, Inc.

A full 3D-navigation system in a suitcase.

Science.gov (United States)

Freysinger, W; Truppe, M J; Gunkel, A R; Thumfart, W F

2001-01-01

To reduce the impact of contemporary 3D-navigation systems on the environment of typical otorhinolaryngologic operating rooms, we demonstrate that a transfer of navigation software to modern high-power notebook computers is feasible and results in a practicable way to provide positional information to a surgeon intraoperatively. The ARTMA Virtual Patient System has been implemented on a Macintosh PowerBook G3 and, in connection with the Polhemus FASTRAK digitizer, provides intraoperative positional information during endoscopic endonasal surgery. Satisfactory intraoperative navigation has been realized in two- and three-dimensional medical image data sets (i.e., X-ray, ultrasound images, CT, and MR) and live video. This proof-of-concept study demonstrates that acceptable ergonomics and excellent performance of the system can be achieved with contemporary high-end notebook computers. Copyright 2001 Wiley-Liss, Inc.

Famous people and genetic disorders: from monarchs to geniuses--a portrait of their genetic illnesses.

Science.gov (United States)

Ho, Nicola C; Park, Susan S; Maragh, Kevin D; Gutter, Emily M

2003-04-15

Famous people with genetic disorders have always been a subject of interest because such news feeds the curiosity the public has for celebrities. It gives further insight into their lives and provides a medical basis for any unexplained or idiosyncratic feature or behavior they exhibit. It draws admiration from society of those who excel in their specialized fields despite the impositions of their genetic illnesses and also elicits sympathy even in the most casual observer. Such news certainly catapults a rare genetic disorder into the realm of public awareness. We hereby present six famous figures: King George III, Toulouse-Lautrec, Queen Victoria, Nicolo Paganini, Abraham Lincoln, and Vincent van Gogh, all of whom made a huge indelible mark in either the history of politics or that of the arts. Copyright 2003 Wiley-Liss, Inc.

A family with X-linked anophthalmia: exclusion of SOX3 as a candidate gene.

Science.gov (United States)

Slavotinek, Anne; Lee, Stephen S; Hamilton, Steven P

2005-10-01

We report on a four-generation family with X-linked anophthalmia in four affected males and show that this family has LOD scores consistent with linkage to Xq27, the third family reported to be linked to the ANOP1 locus. We sequenced the SOX3 gene at Xq27 as a candidate gene for the X-linked anophthalmia based on the high homology of this gene to SOX2, a gene previously mutated in bilateral anophthlamia. However, no amino acid sequence alterations were identified in SOX3. We have improved the definition of the phenotype in males with anophthalmia linked to the ANOP1 locus, as microcephaly, ocular colobomas, and severe renal malformations have not been described in families linked to ANOP1. (c) 2005 Wiley-Liss, Inc.

A de novo SOX10 mutation causing severe type 4 Waardenburg syndrome without Hirschsprung disease.

Science.gov (United States)

Sznajer, Yves; Coldéa, Cristina; Meire, Françoise; Delpierre, Isabelle; Sekhara, Tayeb; Touraine, Renaud L

2008-04-15

Type 4 Waardenburg syndrome represents a well define entity caused by neural crest derivatives anomalies (melanocytes, intrinsic ganglion cells, central, autonomous and peripheral nervous systems) leading, with variable expressivity, to pigmentary anomalies, deafness, mental retardation, peripheral neuropathy, and Hirschsprung disease. Autosomal dominant mode of inheritance is prevalent when Sox10 gene mutation is identified. We report the natural history of a child who presented with synophrys, vivid blue eye, deafness, bilateral complete semicircular canals agenesis with mental retardation, subtle signs for peripheral neuropathy and lack of Hirschsprung disease. SOX10 gene sequencing identified "de novo" splice site mutation (c.698-2A > C). The present phenotype and the genotype findings underline the wide spectrum of SOX10 gene implication in unusual type 4 Waardenburg syndrome patient. Copyright 2008 Wiley-Liss, Inc.

Réponses physiologiques liées à une immersion en eau froide et à une cryostimulation-cryothérapie en corps entier : effets sur la récupération après un exercice musculaire

OpenAIRE

Hausswirth , Christophe; Bieuzen , François; Barbiche , E.; Brisswalter , Jeanick

2010-01-01

International audience; Aims: This review focuses first of all on the effects of the cold and/or contrast water immersion techniques on muscular recovery to determine practical implications for athletes. Then, the present review summarizes the effects of whole-body cryotherapy and its potential benefits.Actualities: The multitude of protocols concerning the cold water immersion technique and the contrast water technique explains the large variety of the results reported in the literature on t...

Genetic analysis and ethnic affinities from two Scytho-Siberian skeletons.

Science.gov (United States)

Ricaut, François-Xavier; Keyser-Tracqui, Christine; Cammaert, Laurence; Crubézy, Eric; Ludes, Bertrand

2004-04-01

We extracted DNA from two skeletons belonging to the Sytho-Siberian population, which were excavated from the Sebÿstei site (dating back 2,500 years) in the Altai Republic (Central Asia). Ancient DNA was analyzed by autosomal short tandem repeats (STRs) and by the sequencing of the hypervariable region 1 (HV1) of the mitochondrial DNA (mtDNA) control region. The results showed that these two skeletons were not close relatives. Moreover, their haplogroups were characteristic of Asian populations. Comparison with the haplogroup of 3,523 Asian and American individuals linked one skeleton with a putative ancestral paleo-Asiatic population and the other with Chinese populations. It appears that the genetic study of ancient populations of Central Asia brings important elements to the understanding of human population movements in Asia. Copyright 2003 Wiley-Liss, Inc.

Channels, pumps, and exchangers in the gill and kidney of freshwater fishes: their role in ionic and acid-base regulation.

Science.gov (United States)

Perry, S F; Shahsavarani, A; Georgalis, T; Bayaa, M; Furimsky, M; Thomas, S L Y

2003-11-01

In freshwater fishes, the gill and kidney are intricately involved in ionic and acid-base regulation owing to the presence of numerous ion channels, pumps, or exchangers. This review summarizes recent developments in branchial and renal ion transport physiology and presents several models that integrate epithelial ion and acid-base movements in freshwater fishes. At the gill, three cell types are potentially involved in ionic uptake: pavement cells, mitochondria-rich (MR) PNA(+) cells, and MR PNA(-) cells. The transfer of acidic or basic equivalents between the fish and its environment is accomplished largely by the gill and is appropriately regulated to correct acid-base imbalances. The kidney, while less important than the gill in overall acid or base excretion, has an essential role in regulating systemic acid-base balance by controlling HCO(3) (-) reabsorption from the filtrate. Copyright 2003 Wiley-Liss, Inc.

Primer and interviews: The dynamic stem cell niche.

Science.gov (United States)

Kiefer, Julie C

2011-03-01

A stem cell niche is a microenvironment that supports self-renewal of a population of stem cells, and their production of differentiated cells. While the definition evokes images of a stem cell Shangri-La-where a serene stem cell pool nestles within a niche that shelters and sustains it-the reality is much more tumultuous. Niches are subject to an ever-changing maelstrom of environmental factors, the ravages of old age, and the sly tactics of disease. Presented here is a basic overview of the different ways in which stem cell niches respond to local and systemic environments, and their impact on stem cell behavior. The primer culminates with a discussion of the topic with stem cell and niche biologists D. Leanne Jones, Ph.D., and Tudorita Tumbar, Ph.D. Copyright © 2011 Wiley-Liss, Inc.

On the age of the hominid fossils at the Sima de los Huesos, Sierra de Atapuerca, Spain: paleomagnetic evidence.

Science.gov (United States)

Parés, J M; Pérez-González, A; Weil, A B; Arsuaga, J L

2000-04-01

We report new paleomagnetic data for the Middle Pleistocene hominid-bearing strata in the Sima de los Huesos, North Spain. Sediments (brown muds with human and bear fossils and the underlying sterile clayey and sandy unit) preserve both normal and reversed magnetic components. The sterile unit has exclusively reversed magnetization, dating back to the Matuyama Chron, and thus is Lower Pleistocene in age. The overlying fossiliferous muds have a dominant normal magnetization that overprints a partially resolved reversed magnetization. These data are compatible with one of the reversal events that occurred during the Brunhes Chron. Combined with the existing U-series dates and evidence from the macro- and microfauna, these paleomagnetic results suggest an age of the hominid fossils between 325 to 205 ka, whereas the underlying sand and silts are older than 780 ka. Copyright 2000 Wiley-Liss, Inc.

Deciphering the colon cancer genes--report of the InSiGHT-Human Variome Project Workshop, UNESCO, Paris 2010.

Science.gov (United States)

Kohonen-Corish, Maija R J; Macrae, Finlay; Genuardi, Maurizio; Aretz, Stefan; Bapat, Bharati; Bernstein, Inge T; Burn, John; Cotton, Richard G H; den Dunnen, Johan T; Frebourg, Thierry; Greenblatt, Marc S; Hofstra, Robert; Holinski-Feder, Elke; Lappalainen, Ilkka; Lindblom, Annika; Maglott, Donna; Møller, Pål; Morreau, Hans; Möslein, Gabriela; Sijmons, Rolf; Spurdle, Amanda B; Tavtigian, Sean; Tops, Carli M J; Weber, Thomas K; de Wind, Niels; Woods, Michael O

2011-04-01

The Human Variome Project (HVP) has established a pilot program with the International Society for Gastrointestinal Hereditary Tumours (InSiGHT) to compile all inherited variation affecting colon cancer susceptibility genes. An HVP-InSiGHT Workshop was held on May 10, 2010, prior to the HVP Integration and Implementation Meeting at UNESCO in Paris, to review the progress of this pilot program. A wide range of topics were covered, including issues relating to genotype-phenotype data submission to the InSiGHT Colon Cancer Gene Variant Databases (chromium.liacs.nl/LOVD2/colon_cancer/home.php). The meeting also canvassed the recent exciting developments in models to evaluate the pathogenicity of unclassified variants using in silico data, tumor pathology information, and functional assays, and made further plans for the future progress and sustainability of the pilot program. © 2011 Wiley-Liss, Inc.

Genotype X/C recombinant (putative genotype I) of hepatitis B virus is rare in Hanoi, Vietnam--genotypes B4 and C1 predominate.

Science.gov (United States)

Phung, Thi Bich Thuy; Alestig, Erik; Nguyen, Thanh Liem; Hannoun, Charles; Lindh, Magnus

2010-08-01

There are eight known genotypes of hepatitis B virus, A-H, and several subgenotypes, with rather well-defined geographic distributions. HBV genotypes were evaluated in 153 serum samples from Hanoi, Vietnam. Of the 87 samples that could be genotyped, genotype B was found in 67 (77%) and genotype C in 19 (22%). All genotype C strains were of subgenotype C1, and the majority of genotype B strains were B4, while a few were B2. The genotype X/C recombinant strain, identified previously in Swedish patients of indigenous Vietnamese origin, was found in one sample. This variant, proposed to be classified as genotype I, has been found recently also by others in Vietnam and Laos. The current study indicates that the genotype X/C recombinant may represent approximately 1% of the HBV strains circulating in Vietnam. (c) 2010 Wiley-Liss, Inc.

Pramipexole modulates the neural network of reward anticipation.

Science.gov (United States)

Ye, Zheng; Hammer, Anke; Camara, Estela; Münte, Thomas F

2011-05-01

Pramipexole is widely prescribed to treat Parkinson's disease. It has been found to cause impulse control disorders such as pathological gambling. To examine how pramipexole modulates the network of reward anticipation, we carried out a pharmacological functional magnetic resonance imaging study with a double-blind, within-subject design. During the anticipation of monetary rewards, pramipexole increased the activity of the nucleus accumbens (NAcc), enhanced the interaction between the NAcc and the anterior insula, but weakened the interaction between the NAcc and the prefrontal cortex. These results suggest that pramipexole may exaggerate incentive and affective responses to possible rewards, but reduce the top-down control of impulses, leading to an increase in impulsive behaviors. This imbalance between the prefrontal-striatum connectivity and the insula-striatum connectivity may represent the neural mechanism of pathological gambling caused by pramipexole. Copyright © 2010 Wiley-Liss, Inc.

Myotonic dystrophy protein kinase (DMPK) induces actin cytoskeletal reorganization and apoptotic-like blebbing in lens cells

Science.gov (United States)

Jin, S.; Shimizu, M.; Balasubramanyam, A.; Epstein, H. F.

2000-01-01

DMPK, the product of the DM locus, is a member of the same family of serine-threonine protein kinases as the Rho-associated enzymes. In DM, membrane inclusions accumulate in lens fiber cells producing cataracts. Overexpression of DMPK in cultured lens epithelial cells led to apoptotic-like blebbing of the plasma membrane and reorganization of the actin cytoskeleton. Enzymatically active DMPK was necessary for both effects; inactive mutant DMPK protein did not produce either effect. Active RhoA but not constitutive GDP-state mutant protein produced similar effects as DMPK. The similar actions of DMPK and RhoA suggest that they may function in the same regulatory network. The observed effects of DMPK may be relevant to the removal of membrane organelles during normal lens differentiation and the retention of intracellular membranes in DM lenses. Copyright 2000 Wiley-Liss, Inc.

Use of statistical models based on radiographic measurements to predict oviposition date and clutch size in rock iguanas (Cyclura nubila)

International Nuclear Information System (INIS)

Alberts, A.C.

1995-01-01

The ability to noninvasively estimate clutch size and predict oviposition date in reptiles can be useful not only to veterinary clinicians but also to managers of captive collections and field researchers. Measurements of egg size and shape, as well as position of the clutch within the coelomic cavity, were taken from diagnostic radiographs of 20 female Cuban rock iguanas, Cyclura nubila, 81 to 18 days prior to laying. Combined with data on maternal body size, these variables were entered into multiple regression models to predict clutch size and timing of egg laying. The model for clutch size was accurate to 0.53 ± 0.08 eggs, while the model for oviposition date was accurate to 6.22 ± 0.81 days. Equations were generated that should be applicable to this and other large Cyclura species. © 1995 Wiley-Liss, Inc

Comparative skeletal features between Homo floresiensis and patients with primary growth hormone insensitivity (Laron Syndrome).

Science.gov (United States)

Hershkovitz, Israel; Kornreich, Liora; Laron, Zvi

2007-10-01

Comparison between the skeletal remains of Homo floresiensis and the auxological and roentgenological findings in a large Israeli cohort of patients with Laron Syndrome (LS, primary or classical GH insensitivity or resistance) revealed striking morphological similarities, including extremely small stature and reduced cranial volume. LS is an autosomal recessive disease caused by a molecular defect of the Growth Hormone (GH) receptor or in the post-receptor cascades. Epidemiological studies have shown that LS occurs more often in consanguineous families and isolates, and it has been described in several countries in South East Asia. It is our conclusion that the findings from the island of Flores, which were attributed to a new species of the genus Homo, may in fact represent a local, highly inbred, Homo sapiens population in whom a mutation for the GH receptor had occurred. (c) 2007 Wiley-Liss, Inc.

Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 A resolution.

Science.gov (United States)

Kosloff, Mickey; Han, Gye Won; Krishna, S Sri; Schwarzenbacher, Robert; Fasnacht, Marc; Elsliger, Marc-André; Abdubek, Polat; Agarwalla, Sanjay; Ambing, Eileen; Astakhova, Tamara; Axelrod, Herbert L; Canaves, Jaume M; Carlton, Dennis; Chiu, Hsiu-Ju; Clayton, Thomas; DiDonato, Michael; Duan, Lian; Feuerhelm, Julie; Grittini, Carina; Grzechnik, Slawomir K; Hale, Joanna; Hampton, Eric; Haugen, Justin; Jaroszewski, Lukasz; Jin, Kevin K; Johnson, Hope; Klock, Heath E; Knuth, Mark W; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Levin, Inna; McMullan, Daniel; Miller, Mitchell D; Morse, Andrew T; Moy, Kin; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Page, Rebecca; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Rife, Christopher L; Sims, Eric; Spraggon, Glen; Sridhar, Vandana; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; White, Aprilfawn; Wolf, Guenter; Xu, Qingping; Hodgson, Keith O; Wooley, John; Deacon, Ashley M; Godzik, Adam; Lesley, Scott A; Wilson, Ian A

2006-11-15

Glutathione S-transferases (GSTs) comprise a diverse superfamily of enzymes found in organisms from all kingdoms of life. GSTs are involved in diverse processes, notably small-molecule biosynthesis or detoxification, and are frequently also used in protein engineering studies or as biotechnology tools. Here, we report the high-resolution X-ray structure of Atu5508 from the pathogenic soil bacterium Agrobacterium tumefaciens (atGST1). Through use of comparative sequence and structural analysis of the GST superfamily, we identified local sequence and structural signatures, which allowed us to distinguish between different GST classes. This approach enables GST classification based on structure, without requiring additional biochemical or immunological data. Consequently, analysis of the atGST1 crystal structure suggests a new GST class, distinct from previously characterized GSTs, which would make it an attractive target for further biochemical studies. (c) 2006 Wiley-Liss, Inc.

Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement.

Science.gov (United States)

Basolo, Fulvio; Giannini, Riccardo; Toniolo, Antonio; Casalone, Rosario; Nikiforova, Marina; Pacini, Furio; Elisei, Rossella; Miccoli, Paolo; Berti, Piero; Faviana, Pinuccia; Fiore, Lisa; Monaco, Carmen; Pierantoni, Giovanna Maria; Fedele, Monica; Nikiforov, Yuri E; Santoro, Massimo; Fusco, Alfredo

2002-02-10

A novel human thyroid papillary carcinoma cell line (FB-2) has been established and characterized. FB-2 cells harbor the RET/PTC1 chimeric oncogene in which the RET kinase domain is fused to the H4 gene. FB-2 cells neither formed colonies in semisolid media nor induced tumors after heterotransplant into severe combined immunodeficient mice. However, HMGI(Y), HMGI-C and c-myc genes, which are associated to thyroid cell transformation, were abundantly expressed in FB-2 cells but not in normal thyroid cells. FB-2 cells only partially retained the differentiated thyroid phenotype. In fact, the PAX-8 gene, which codes for a transcriptional factor required for thyroid cell differentiation, was expressed, while thyroglobulin, TSH-receptor and thyroperoxidase genes were not. Moreover, FB-2 cells produced high levels of interleukin (IL)-6 and IL-8. Copyright 2001 Wiley-Liss, Inc.

Brief communication: Is variation in the cranial capacity of the Dmanisi sample too high to be from a single species?

Science.gov (United States)

Lee, Sang-Hee

2005-07-01

This study uses data resampling to test the null hypothesis that the degree of variation in the cranial capacity of the Dmanisi hominid sample is within the range variation of a single species. The statistical significance of the variation in the Dmanisi sample is examined using simulated distributions based on comparative samples of modern humans, chimpanzees, and gorillas. Results show that it is unlikely to find the maximum difference observed in the Dmanisi sample in distributions of female-female pairs from comparative single-species samples. Given that two sexes are represented, the difference in the Dmanisi sample is not enough to reject the null hypothesis of a single species. Results of this study suggest no compelling reason to invoke multiple taxa to explain variation in the cranial capacity of the Dmanisi hominids. (c) 2004 Wiley-Liss, Inc

Magneto-motive detection of tissue-based macrophages by differential phase optical coherence tomography.

Science.gov (United States)

Oh, Junghwan; Feldman, Marc D; Kim, Jihoon; Kang, Hyun Wook; Sanghi, Pramod; Milner, Thomas E

2007-03-01

A novel method to detect tissue-based macrophages using a combination of superparamagnetic iron oxide (SPIO) nanoparticles and differential phase optical coherence tomography (DP-OCT) with an external oscillating magnetic field is reported. Magnetic force acting on iron-laden tissue-based macrophages was varied by applying a sinusoidal current to a solenoid containing a conical iron core that substantially focused and increased magnetic flux density. Nanoparticle motion was detected with DP-OCT, which can detect tissue movement with nanometer resolution. Frequency response of iron-laden tissue movement was twice the modulation frequency since the magnetic force is proportional to the product of magnetic flux density and gradient. Results of our experiments indicate that DP-OCT can be used to identify tissue-based macrophage when excited by an external focused oscillating magnetic field. (c) 2007 Wiley-Liss, Inc

Occupational health crossing borders part 2: Comparison of 18 occupational health systems across the globe.

Science.gov (United States)

Radon, Katja; Ehrenstein, Vera; Nowak, Dennis; Bigaignon-Cantineau, Janine; Gonzalez, Maria; Vellore, Arun Dev; Zamora, Veronica Enzina; Gupta, Neeraj; Huang, Lirong; Kandkers, Salamat; Lanza, Ana María Menchú; Garcia, Leila Posenato; Patsis, Keti Stylianos; Rojas, Ana Maria Sanchez; Shoma, Ashraf; Verbeek, Jos

2010-01-01

Occupational health and safety (OHS) is considered one of the most important factors for a sustainable development; however, it is often considered a luxury by decision-makers. This article compares OHS systems of 18 countries at different stages of development. In an international summer school, structure of the national OHS system, definition of occupational accidents and diseases, procedures for compensation claims, outcome (expressed as incidence of occupational accidents) and training opportunities were presented. National OHS systems ranged from non-existent to systems implemented almost 200 years ago. Priorities, incidence of occupational accidents and training opportunities varied. Common problems included the lack of OHS service for small enterprises and in rural areas. International training programs like this summer school might enhance the exchange about OHS opportunities around the globe and contribute to improved workers health. (c) 2009 Wiley-Liss, Inc.

How long do the short-term violent video game effects last?

Science.gov (United States)

Barlett, Christopher; Branch, Omar; Rodeheffer, Christopher; Harris, Richard

2009-01-01

How long do the effects of the initial short-term increase in aggression and physiological arousal last after violent video game play? Study 1 (N=91) had participants complete pre- and postvideo game measures of aggressive thoughts, aggressive feelings, and heart rate. Then, participants completed Time 3 measures after 4 min or 9 min of delay. Study 2 employed a similar procedure, but had participants (N=91) complete the hot sauce paradigm to assess aggressive behavior after a 0, 5, or 10 min delay. First, results indicated that aggressive feelings, aggressive thoughts, aggressive behavior, and heart rate initially increased after violent video game play. Second, results of the delay condition revealed that the increase in aggressive feelings and aggressive thoughts lasted less than 4 min, whereas heart rate and aggressive behavior lasted 4-9 min. Copyright 2009 Wiley-Liss, Inc.

Banking a hemi-abdominal DIEP flap: a pilot report of indications, technique, and utility.

Science.gov (United States)

Shridharani, Sachin M; Singh, Navin K; Taylor, Jesse A; Rosson, Gedge D

2009-01-01

We present a pilot report of "banking" the contralateral hemi-abdominal deep inferior epigastric perforator (DIEP) flap under the abdominal closure in patients undergoing unilateral autologous breast reconstruction when a hemi-abdominal flap suffices. Four patients undergoing unilateral autologous breast reconstruction with a hemi-abdominal DIEP or superficial inferior epigastric artery flap had their contralateral hemi-abdominal flap left in position, or "banked," under their abdominal closure to be used in case of failure. This novel method may be of assistance when a free microvascular hemi-abdominal flap is felt to be threatened or suspect. It provides a life-boat for the younger and experienced surgeon alike, and most importantly, for the breast cancer survivor. Economic analysis of the technique reveals that the contralateral hemi-abdominal flap should be banked more often than intuition alone would suggest. (c) 2009 Wiley-Liss, Inc.

Hierarchical functional modularity in the resting-state human brain.

Science.gov (United States)

Ferrarini, Luca; Veer, Ilya M; Baerends, Evelinda; van Tol, Marie-José; Renken, Remco J; van der Wee, Nic J A; Veltman, Dirk J; Aleman, André; Zitman, Frans G; Penninx, Brenda W J H; van Buchem, Mark A; Reiber, Johan H C; Rombouts, Serge A R B; Milles, Julien

2009-07-01

Functional magnetic resonance imaging (fMRI) studies have shown that anatomically distinct brain regions are functionally connected during the resting state. Basic topological properties in the brain functional connectivity (BFC) map have highlighted the BFC's small-world topology. Modularity, a more advanced topological property, has been hypothesized to be evolutionary advantageous, contributing to adaptive aspects of anatomical and functional brain connectivity. However, current definitions of modularity for complex networks focus on nonoverlapping clusters, and are seriously limited by disregarding inclusive relationships. Therefore, BFC's modularity has been mainly qualitatively investigated. Here, we introduce a new definition of modularity, based on a recently improved clustering measurement, which overcomes limitations of previous definitions, and apply it to the study of BFC in resting state fMRI of 53 healthy subjects. Results show hierarchical functional modularity in the brain. Copyright 2009 Wiley-Liss, Inc

Why does starvation make bones fat?

Science.gov (United States)

Devlin, Maureen J

2011-01-01

Body fat, or adipose tissue, is a crucial energetic buffer against starvation in humans and other mammals, and reserves of white adipose tissue (WAT) rise and fall in parallel with food intake. Much less is known about the function of bone marrow adipose tissue (BMAT), which are fat cells found in bone marrow. BMAT mass actually increases during starvation, even as other fat depots are being mobilized for energy. This review considers several possible reasons for this poorly understood phenomenon. Is BMAT a passive filler that occupies spaces left by dying bone cells, a pathological consequence of suppressed bone formation, or potentially an adaptation for surviving starvation? These possibilities are evaluated in terms of the effects of starvation on the body, particularly the skeleton, and the mechanisms involved in storing and metabolizing BMAT during negative energy balance. Copyright © 2011 Wiley-Liss, Inc.

A web site for calculating the degree of chirality.

Science.gov (United States)

Zayit, Amir; Pinsky, Mark; Elgavi, Hadassah; Dryzun, Chaim; Avnir, David

2011-01-01

The web site, http://www.csm.huji.ac.il/, uses the Continuous Chirality Measure to evaluate quantitatively the degree of chirality of a molecule, a structure, a fragment. The value of this measure ranges from zero, the molecule is achiral, to higher values (the upper limit is 100); the higher the chirality value, the more chiral the molecule is. The measure is based on the distance between the chiral molecule and the nearest structure that is achiral. Questions such as the following can be addressed: by how much is one molecule more chiral than the other? how does chirality change along conformational motions? is there a correlation between chirality and enantioselectivity in a series of molecules? Both elementary and advanced features are offered. Related calculation options are the symmetry measures and shape measures. Copyright © 2009 Wiley-Liss, Inc.

Anatomical subdivisions of the stomach of the Bactrian camel (Camelus bactrianus).

Science.gov (United States)

Wang, J L; Lan, G; Wang, G X; Li, H Y; Xie, Z M

2000-08-01

Twenty stomachs of Bactrian camels (Camelus bactrianus) were studied by gross dissection. Based on the configuration of the stomach and the structure of the mucous membrane, the stomach was divided into three ventricles that differ from the arrangement described for ox and sheep. The first and second ventricles of the proventriculus of camel form one stomach rather than two different stomachs. These ventricles of the proventriculus do not correspond to the rumen and reticulum of ox and sheep. The third ventricle appears to be the abomasum. One part of the abomasum has reticular mucosal folds that indicate it is not the reticulum. A second part of the abomasum has longitudinal mucosal folds suggesting it is not the omasum. Three glandular sac areas associated with the preventriculus and abomasum are also described. Copyright 2000 Wiley-Liss, Inc.

Phenotypic variability of Filipino beta(o)-thalassemia/HbE patients in Indonesia.

Science.gov (United States)

Setianingsih, I; Williamson, R; Daud, D; Harahap, A; Marzuki, S; Forrest, S

1999-09-01

Three Indonesian patients with identical genotypes, each compound heterozygotes for Filipino beta(o)-thalassemia/HbE, expressed different clinical severities. One patient has mild disease and is transfusion independent, while the other two are severely affected and transfusion dependent. The size of the Filipino beta(o)-globin gene deletion was confirmed to be 45 kb, resolving conflicting values given in the literature. Neither ameliorating genetic factors such as alpha-globin gene deletions or the XmnI restriction site polymorphism at position -158 upstream of the (G)gamma-globin gene, nor differences in beta-globin gene haplotype, explain the phenotypic variation. These observations have implications for the development of antenatal diagnosis in Indonesia, as at present it is not possible to give an accurate prediction of severity of phenotype for this common genotype. Copyright 1999 Wiley-Liss, Inc.

Misuse of anecdotes in primatology: lessons from citation analysis.

Science.gov (United States)

Sarringhaus, Lauren A; McGrew, William C; Marchant, Linda F

2005-03-01

This study analyzes the accuracy of anecdotes cited in behavioral primatology publications. Anecdotes (n=1 cases) recounting tool use were sought in the four main primatological journals. Citations of anecdotes in the scientific literature that met three criteria were systematically coded for recognition and accuracy. The results showed that 60% of the time, authors who cited anecdotes did not explicitly acknowledge them as such. To a lesser extent, the citations exaggerated the frequency of anecdotal events or misrepresented their status. For tool use specifically, the actor was misreported more often than the tool or its target. Multiple citations were incorrect more often than single citations. Overall, it seems that citation of anecdotes is problematic and may have far-reaching implications in terms of misleading overgeneralizations. Primatologists should take care in citing singular or rare events. Copyright (c) 2005 Wiley-Liss, Inc.

A review of the terms agglomerate and aggregate with a recommendation for nomenclature used in powder and particle characterization.

Science.gov (United States)

Nichols, Gary; Byard, Stephen; Bloxham, Mark J; Botterill, Joanne; Dawson, Neil J; Dennis, Andrew; Diart, Valerie; North, Nigel C; Sherwood, John D

2002-10-01

The terms "agglomerate" and "aggregate" are widely used by powder technologists to describe assemblages of particles that are found in dry powders and powders in liquid suspensions. Each term has a specific meaning but, unfortunately, they are frequently interchanged at will and this has resulted in universal confusion. This confusion is perpetuated by conflicting definitions in national and international standards and this presents problems when describing powder properties or communicating results in reports and research papers. This paper reviews the current status of the definitions, with particular emphasis on their use in the pharmaceutical industry. It is proposed that just one term, agglomerate, should be used to describe an assemblage of particles in a powder and that the term aggregate should be confined to pre-nucleation structures. Copyright 2002 Wiley-Liss Inc. and the American Pharmaceutical Association

Disparities by ethnicity, language, and immigrant status in occupational health experiences among Las Vegas hotel room cleaners.

Science.gov (United States)

Premji, Stéphanie; Krause, Niklas

2010-10-01

We examined disparities in workers' occupational health experiences. We surveyed 941 unionized Las Vegas hotel room cleaners about their experiences with work-related pain and with employers, physicians, and workers' compensation. Data were analyzed for all workers and by ethnicity, language, and immigrant status. Hispanic and English as second language (ESL) workers were more likely than their counterparts to report work-related pain and, along with immigrant workers, to miss work because of this pain. Hispanic, ESL, and immigrant workers were not consistently at a disadvantage with regard to their own responses to work-related pain but were so with respect to reported responses by workers' compensation, physicians, and employers. There are indications of disparities in occupational health experiences within this job title. The use of different group classifications, while implying different mechanisms, produced similar results. © 2010 Wiley-Liss, Inc.

Use of large-scale chromatography in the preparation of armodafinil.

Science.gov (United States)

Hauck, Willy; Adam, Philippe; Bobier, Christelle; Landmesser, Nelson

2008-08-01

Armodafinil, the (R)-enantiomer of modafinil, is a medication used to treat the excessive sleepiness associated with narcolepsy, obstructive sleep apnea/hypopnea syndrome, and shift work sleep disorder. We report here the chemical development of armodafinil and the investigations that led to a commercial route to prepare this pure enantiomer. Three synthetic approaches were used to provide the chiral sulfoxide. Resolution via preferential crystallization was used for phase I clinical trials and was subsequently replaced by chiral chromatography, enabling us to pursue a rapid filing and registration of the API. Finally, the commercial route was developed and employed asymmetric oxidation catalyzed by a titanium(IV) isopropoxide and diethyl tartrate system. The advantages of choosing a chromatographic development pathway to expedite registration while concurrently developing an economical chiral synthesis route is discussed in the context of armodafinil development. (c) 2008 Wiley-Liss, Inc.

Nikola Tesla: the man behind the magnetic field unit.

Science.gov (United States)

Roguin, Ariel

2004-03-01

The magnetic field strength of both the magnet and gradient coils used in MR imaging equipment is measured in Tesla units, which are named for Nikola Tesla. This article presents the life and achievements of this Serbian-American inventor and researcher who discovered the rotating magnetic field, the basis of most alternating-current machinery. Nikola Tesla had 700 patents in the United States and Europe that covered every aspect of science and technology. Tesla's discoveries include the Tesla coil, AC electrical conduction, improved lighting, newer forms of turbine engines, robotics, fluorescent light, wireless transmission of electrical energy, radio, remote control, discovery of cosmic radio waves, and the use of the ionosphere for scientific purposes. He was a genius whose discoveries had a pivotal role in advancing us into the modern era. Copyright 2004 Wiley-Liss, Inc.

Toxicity assessment of molecularly targeted drugs incorporated into multiagent chemotherapy regimens for pediatric acute lymphocytic leukemia (ALL): review from an international consensus conference.

Science.gov (United States)

Horton, Terzah M; Sposto, Richard; Brown, Patrick; Reynolds, C Patrick; Hunger, Stephen P; Winick, Naomi J; Raetz, Elizabeth A; Carroll, William L; Arceci, Robert J; Borowitz, Michael J; Gaynon, Paul S; Gore, Lia; Jeha, Sima; Maurer, Barry J; Siegel, Stuart E; Biondi, Andrea; Kearns, Pamela R; Narendran, Aru; Silverman, Lewis B; Smith, Malcolm A; Zwaan, C Michel; Whitlock, James A

2010-07-01

One of the challenges of incorporating molecularly targeted drugs into multi-agent chemotherapy (backbone) regimens is defining dose-limiting toxicities (DLTs) of the targeted agent against the background of toxicities of the backbone regimen. An international panel of 22 pediatric acute lymphocytic leukemia (ALL) experts addressed this issue (www.ALLNA.org). Two major questions surrounding DLT assessment were explored: (1) how toxicities can be best defined, assessed, and attributed; and (2) how effective dosing of new agents incorporated into multi-agent ALL clinical trials can be safely established in the face of disease- and therapy-related systemic toxicities. The consensus DLT definition incorporates tolerance of resolving Grade 3 and some resolving Grade 4 toxicities with stringent safety monitoring. This functional DLT definition is being tested in two Children's Oncology Group (COG) ALL clinical trials. Copyright 2010 Wiley-Liss, Inc.

2014 Zero Waste Strategic Plan Executive Summary.

Energy Technology Data Exchange (ETDEWEB)

Wrons, Ralph J.

2016-05-01

Sandia National Laboratories/New Mexico is located in Albuquerque, New Mexico, primarily on Department of Energy (DOE) permitted land on approximately 2,800 acres of Kirtland Air Force Base. There are approximately 5.5 million square feet of buildings, with a workforce of approximately 9200 personnel. Sandia National Laboratories Materials Sustainability and Pollution Prevention (MSP2) program adopted in 2008 an internal team goal for New Mexico site operations for Zero Waste to Landfill by 2025. Sandia solicited a consultant to assist in the development of a Zero Waste Strategic Plan. The Zero Waste Consultant Team selected is a partnership of SBM Management Services and Gary Liss & Associates. The scope of this Plan is non-hazardous solid waste and covers the life cycle of material purchases to the use and final disposal of the items at the end of their life cycle.

Bilateral carpal valgus deformity in hand-reared cheetah cubs (Acinonyx jubatus).

Science.gov (United States)

Bell, Katherine M; van Zyl, Malan; Ugarte, Claudia E; Hartman, Angela

2011-01-01

Four hand-reared cheetah cubs (Acinonyx jubatus) exhibited progressively severe bilateral valgus deformity of the carpi (CV) during the weaning period. Radiographs of the thoracic limbs suggested normal bone ossification, and serum chemistry was unremarkable. All affected cubs developed CV shortly after the onset of gastroenteritis, which was treated medically, and included use of a prescription diet. A sudden decrease in growth rate was associated with gastrointestinal disease. Before gastroenteritis and CV, affected cubs had higher growth rates than unaffected cubs, despite similar mean daily energy intake. Return to normal thoracic limb conformation was consequent to dietary manipulation (including a reduction in energy intake and vitamin and mineral supplementation), as well as decreased growth rates and recovery from gastroenteritis. The cause of the CV is likely to have been multi-factorial with potentially complex physiological interactions involved. © 2010 Wiley-Liss, Inc.

Chromosome 2 short arm translocations revealed by M-FISH analysis of neuroblastoma cell lines.

Science.gov (United States)

Van Roy, N; Van Limbergen, H; Vandesompele, J; Van Gele, M; Poppe, B; Laureys, G; De Paepe, A; Speleman, F

2000-12-01

M-FISH analysis was performed on 18 neuroblastoma cell lines, which were previously studied with cytogenetic, standard FISH and CGH data. One of the most striking findings of this study was the detection of chromosome 2 short arm rearrangements in 61% of the investigated cell lines. These rearrangements resulted from translocations with various partner chromosomes. All translocations, except one were unbalanced, leading to the consistent gain of chromosome segment 2pter-p22. A cryptic balanced translocation t(2;4) was observed with a breakpoint located in the vicinity of MYCN in cell line NBL-S. Combination of M-FISH results together with cytogenetic, standard FISH and CGH data yielded the most comprehensive description of chromosome 2 short arm rearrangements, leading to a consistent gain of chromosome 2 short arm material. Copyright 2000 Wiley-Liss, Inc.

Re: Evaluation of the size and type of free particulates collected from unused asbestos-containing brake components as related to potential for respirability.

Science.gov (United States)

Paustenbach, Dennis J; Finley, Brent L; Sheehan, Patrick J; Brorby, Gregory P

2006-01-01

In Atkinson et al. 2004 rinsates of unused brake components were analyzed by transmission electron microscopy (TEM) for the presence of asbestos fibers. We do not believe that the findings of Atkinson et al. are informative and could have been predicted based on the study design and the fact that one would expect to find measurable TEM asbestos fibers on an unused brake component. We also find that the paper did not provide a full or even partial discussion of the published literature with respect to industrial hygiene or epidemiology data. The findings of Atkinson et al. do not, in our view, "further raise concerns" about historical asbestos exposures experienced by automotive mechanics because of the vast amount of published literature to the contrary. Am. J. Ind. Med. 49:60-61, 2006. (c) 2005 Wiley-Liss, Inc.

Eph receptors and ephrins in neuron-astrocyte communication at synapses.

Science.gov (United States)

Murai, Keith K; Pasquale, Elena B

2011-11-01

Neuron-glia communication is essential for regulating the properties of synaptic connections in the brain. Astrocytes, in particular, play a critical and complex role in synapse development, maintenance, and plasticity. Likewise, neurons reciprocally influence astrocyte physiology. However, the molecular signaling events that enable astrocytes and neurons to effectively communicate with each other are only partially defined. Recent findings have revealed that Eph receptor tyrosine kinases and ephrins play an important role in contact-dependent neuron-glia communication at synapses. Upon binding, these two families of cell surface-associated proteins trigger bidirectional signaling events that regulate the structural and physiological properties of both neurons and astrocytes. This review will focus on the emerging role of Eph receptors and ephrins in neuron-astrocyte interaction at synapses and discuss implications for synaptic plasticity, behavior, and disease. Copyright © 2011 Wiley-Liss, Inc.

Non-ablative skin tightening with radiofrequency in Asian skin.

Science.gov (United States)

Kushikata, Nobuharu; Negishi, Kei; Tezuka, Yukiko; Takeuchi, Kaori; Wakamatsu, Shingo

2005-02-01

The recent successful application of radiofrequency (RF) in non-ablative skin tightening for skin laxity has attracted attention worldwide. The efficacy and clinical effect of RF were assessed in Asian skin, with additional study on the duration of the effect and any complications. Eighty-five Japanese females were enrolled in the study for treatment of nasolabial folds, marionette lines, and sagging jowls with 6-month follow-up. RF treatment was effective for nasolabial folds, marionette lines, and jowls. Objective physician evaluation found relatively good improvement at 3 months post-treatment, and even better improvement at the 6-month evaluation. RF treatment was very satisfactory for skin tightening in Asian facial skin. When compared with published literature from the United States, the results suggested that there might be race-related differences in the treatment parameters. (c) 2005 Wiley-Liss, Inc.

The molecular genetics of holoprosencephaly.

Science.gov (United States)

Roessler, Erich; Muenke, Maximilian

2010-02-15

Holoprosencephaly (HPE) has captivated the imagination of Man for millennia because its most extreme manifestation, the single-eyed cyclopic newborn infant, brings to mind the fantastical creature Cyclops from Greek mythology. Attempting to understand this common malformation of the forebrain in modern medical terms requires a systematic synthesis of genetic, cytogenetic, and environmental information typical for studies of a complex disorder. However, even with the advances in our understanding of HPE in recent years, there are significant obstacles remaining to fully understand its heterogeneity and extensive variability in phenotype. General lessons learned from HPE will likely be applicable to other malformation syndromes. Here we outline the common, and rare, genetic and environmental influences on this conserved developmental program of forebrain development and illustrate the similarities and differences between these malformations in humans and those of animal models. 2010 Wiley-Liss, Inc.

Prévalence et caractéristiques des effets indésirables des antihypertenseurs chez les patients suivis en ambulatoire au Centre Hospitalier Universitaire Yalgado Ouédraogo

Science.gov (United States)

Millogo, Georges Rosario Christian; Zongo, Ragomzingba Frank Edgard; Benao, Anita; Youl, Estelle Noëla Hoho; Bassoleth, Blaise Alexandre Bazona; Ouédraogo, Moussa; Zabsonré, Patrice; Guissou, Innocent Pierre

2018-01-01

La prise en charge médicamenteuse de l'hypertension artérielle (HTA) entraine des effets indésirables qui peuvent être gênants et ainsi influencer l'observance du patient. Nous avons étudié ces effets indésirables dans le service de cardiologie du Centre hospitalier universitaire Yalgado Ouédraogo afin de déterminer leurs fréquences et leurs caractéristiques. Il s'agissait d'une étude transversale de juillet à septembre 2015 chez les patients suivis en ambulatoire pour HTA. Les données ont été obtenues à partir de l'interrogatoire, des carnets de suivi des patients et des fiches de consultations. Au total 278 patients ont été inclus. La population d'étude incluait 69,1% de femmes. L'âge moyen était de 52,2 ans avec des extrêmes de 23 et 86 ans. Quatre vingt et sept virgule huit pourcent (87,8%) vivaient en milieu urbain. Le tabagisme, la dyslipidémie et les antécédents familiaux d'HTA représentaient respectivement 9%, 35,6% et 57,2%. Au plan thérapeutique, 43,2% étaient sous monothérapie, 35,6% sous bithérapie à l'initiation du traitement. Les inhibiteurs calciques (59,7%) étaient la classe thérapeutique la plus utilisée. La prévalence globale des effets indésirables était de 60,1%. Les inhibiteurs calciques étaient impliqués dans 53,6% suivis des diurétiques (48,6%) dans la survenue de l'effet indésirable. La prévalence spécifique par molécule était 28,1% pour l'amlodipine et 24,5% pour l'hydrochlorothiazide. La diurèse excessive (13,7%), la toux (12,9%) et les vertiges (11,5%) étaient les effets indésirables les plus fréquemment évoqués par les patients. Le système nerveux central et périphérique et le système ostéo-musculaire étaient les systèmes les plus atteints. Les effets indésirables sont un déterminant majeur de l'adhésion aux traitements antihypertenseur, car leur impact sur la vie quotidienne des patients peut s'avérer significatif. PMID:29875965

Characteristics of outage radiation fields around various reactor components

International Nuclear Information System (INIS)

Verzilov, Y.; Husain, A.; Corbin, G.

2008-01-01

Full text: Activity monitoring surveys, consisting of gamma spectroscopy and dose rate measurements, of various CANDU station components such as the reactor face, feeder cabinet, steam generators and moderator heat exchangers are often performed during shutdown in order to trend the transport of activity around the primary heat transport and moderator systems. Recently, the increased dose expenditure for work such as feeder inspection and replacement in the reactor vault has also spurred interest in improved characterization of the reactor face fields to facilitate better ALARA decision making and hence a reduction in future dose expenditures. At present, planning for reactor face work is hampered by insufficient understanding of the relative contribution of the various components to the overall dose. In addition to the increased dose expenditure for work at the reactor face, maintenance work associated with horizontal flux detectors and liquid injection systems has also resulted in elevated dose expenditures. For instance at Darlington, radiation fields in the vicinity of horizontal flux detectors (HFD) and Liquid Injection Shutdown System (LISS) nozzle bellows are trending upwards with present contact fields being in the range 16-70 rem/h and working distance fields being in the range 100-500 mrem/h. This paper presents findings based on work currently being funded by the CANDU Owners Group. Measurements were performed at Ontario Power Generation's Pickering and Darlington nuclear stations. Specifically, the following are addressed: Characteristics of Reactor Vault Fields; Characteristics of Steam Generator Fields; Characteristics of Moderator Heat Exchanger Fields. Measurements in the reactor vault were performed at the reactor face, along the length of end fittings, along the length of feeders, at the bleed condenser and at the HFD and LISS nozzle bellows. Steam generator fields were characterized at various elevations above the tube sheet, with and without the

Caractérisation des différents types de fibres musculaires dans plusieurs espèces : production et utilisation d'anticorps monoclonaux dirigés contre les chaînes lourdes de myosine rapide IIa et IIb

OpenAIRE

Société Biocytex; Picard, Brigitte; Lefaucheur, Louis; Fauconneau, Benoit; Rémignon, Hervé; Cherel, Yan; Barrey, Eric; Nédelec, J.

1998-01-01

Des anticorps monoclonaux dirigés contre les chaînes lourdes de myosine (MHC : myosin heavy chain) de différentes espèces d’animaux : bovin, porc, poisson, poulet, dinde, cheval ont été produits. Ils ont été testés par immunohistologie sur des coupes de muscle squelettique chez le bovin, le porc, le poisson, le poulet et la dinde et par ELISA chez le cheval. Les différents anticorps retenus dans ce projet permettent de nouvelles applications pour l’étude du muscle squelettique. En particulier...

Land, language, and loci: mtDNA in Native Americans and the genetic history of Peru.

Science.gov (United States)

Lewis, Cecil M; Tito, Raúl Y; Lizárraga, Beatriz; Stone, Anne C

2005-07-01

Despite a long history of complex societies and despite extensive present-day linguistic and ethnic diversity, relatively few populations in Peru have been sampled for population genetic investigations. In order to address questions about the relationships between South American populations and about the extent of correlation between genetic distance, language, and geography in the region, mitochondrial DNA (mtDNA) hypervariable region I sequences and mtDNA haplogroup markers were examined in 33 individuals from the state of Ancash, Peru. These sequences were compared to those from 19 American Indian populations using diversity estimates, AMOVA tests, mismatch distributions, a multidimensional scaling plot, and regressions. The results show correlations between genetics, linguistics, and geographical affinities, with stronger correlations between genetics and language. Additionally, the results suggest a pattern of differential gene flow and drift in western vs. eastern South America, supporting previous mtDNA and Y chromosome investigations. (c) 2004 Wiley-Liss, Inc

Relational aggression in marriage.

Science.gov (United States)

Carroll, Jason S; Nelson, David A; Yorgason, Jeremy B; Harper, James M; Ashton, Ruth Hagmann; Jensen, Alexander C

2010-01-01

Drawing from developmental theories of relational aggression, this article reports on a study designed to identify if spouses use relationally aggressive tactics when dealing with conflict in their marriage and the association of these behaviors with marital outcomes. Using a sample of 336 married couples (672 spouses), results revealed that the majority of couples reported that relationally aggressive behaviors, such as social sabotage and love withdrawal, were a part of their marital dynamics, at least to some degree. Gender comparisons of partner reports of their spouse's behavior revealed that wives were significantly more likely to be relationally aggressive than husbands. Structural equation modeling demonstrated that relational aggression is associated with lower levels of marital quality and greater marital instability for both husbands and wives. Implications are drawn for the use of relational aggression theory in the future study of couple conflict and marital aggression. (c) 2010 Wiley-Liss, Inc.

Describing the organization of dominance relationships by dominance-directed tree method.

Science.gov (United States)

Izar, Patrícia; Ferreira, Renata G; Sato, Takechi

2006-02-01

Methods to describe dominance hierarchies are a key tool in primatology studies. Most current methods are appropriate for analyzing linear and near-linear hierarchies; however, more complex structures are common in primate groups. We propose a method termed "dominance-directed tree." This method is based on graph theory and set theory to analyze dominance relationships in social groups. The method constructs a transitive matrix by imposing transitivity to the dominance matrix and produces a graphical representation of the dominance relationships, which allows an easy visualization of the hierarchical position of the individuals, or subsets of individuals. The method is also able to detect partial and complete hierarchies, and to describe situations in which hierarchical and nonhierarchical principles operate. To illustrate the method, we apply a dominance tree analysis to artificial data and empirical data from a group of Cebus apella. Copyright 2006 Wiley-Liss, Inc.

Role of motivation to respond to provocation, the social environment, and trait aggression in alcohol-related aggression.

Science.gov (United States)

Tremblay, Paul F; Mihic, Ljiljana; Graham, Kathryn; Jelley, Jennifer

2007-01-01

Little attention has been paid to the motivation to respond to provocation and to the interaction between this motivation, alcohol, the drinking environment, and individual characteristics. Undergraduates at six Canadian universities (N = 1,232) read three vignettes describing conflict situations with social environmental manipulations while imagining themselves as either sober or intoxicated. Self-ratings assessed likelihood of assertive and aggressive responses and motivational indices of anger, offensiveness of the instigator's actions, and importance to respond to the provocation. Respondents also completed a measure of trait aggression. Multi-group structural equation models supported the hypothesis that perceived likelihood of reactive aggression is influenced by perceived alcohol intoxication, gender, trait aggression, social environmental factors, and motivation to respond to the provocation. In addition, a number of interactions were found among the predictors. These results provide insight into the types of factors that may influence aggression in drinking situations. Copyright 2007 Wiley-Liss, Inc.

Donor cell differentiation, reprogramming, and cloning efficiency: elusive or illusive correlation?

Science.gov (United States)

Oback, B; Wells, D N

2007-05-01

Compared to other assisted reproductive technologies, mammalian nuclear transfer (NT) cloning is inefficient in generating viable offspring. It has been postulated that nuclear reprogramming and cloning efficiency can be increased by choosing less differentiated cell types as nuclear donors. This hypothesis is mainly supported by comparative mouse cloning experiments using early blastomeres, embryonic stem (ES) cells, and terminally differentiated somatic donor cells. We have re-evaluated these comparisons, taking into account different NT procedures, the use of donor cells from different genetic backgrounds, sex, cell cycle stages, and the lack of robust statistical significance when post-blastocyst development is compared. We argue that while the reprogrammability of early blastomeres appears to be much higher than that of somatic cells, it has so far not been conclusively determined whether differentiation status affects cloning efficiency within somatic donor cell lineages. Copyright (c) 2006 Wiley-Liss, Inc.

Demographic and evolutionary trajectories of the Guarani and Kaingang natives of Brazil.

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Marrero, Andrea R; Silva-Junior, Wilson A; Bravi, Cláudio M; Hutz, Mara H; Petzl-Erler, Maria L; Ruiz-Linares, Andres; Salzano, Francisco M; Bortolini, Maria C

2007-02-01

A total of 278 individuals from two Brazilian Indian tribes (Guarani and Kaingang) living in five different localities had their mitochondrial DNA sequenced for the first hypervariable segment (HVS-I), and a fraction of them was also studied for seven biallelic Y-chromosome polymorphisms. Nineteen HVS-I lineages were detected, which showed distinct distributions in the two tribes. The G(ST) value obtained with the mtDNA data is about 5 times higher for the Guarani as compared to the Kaingang, suggesting a higher level of differentiation between the three Guarani partialities than between the two Kaingang villages. Non-Amerindian admixture varied with sex and in the Guarani was only observed through the paternal line. Using these data and those of other Tupian and Jêan tribes, it was possible to make inferences about past migratory movements and the genetic differentiation of these populations. Copyright 2006 Wiley-Liss, Inc.

Transplantation and microsurgical anastomosis of free omental grafts: experimental animal model of a new operative technique in dogs.

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Pap-Szekeres, Jozsef; Cserni, Gabor; Furka, Istvan; Svebis, Mihaly; Cserni, Tamas; Brath, Endre; Nemeth, Norbert; Miko, Iren

2003-01-01

Our objective was the elaboration of a new animal model for the free transplantation of an omental flap and the examination of its viability in dogs. The cooled omental flap from the abdomen was freely transplanted to the lateral cervical region, and its blood supply was established with microsurgical anastomoses. The technique was developed in 5 dogs, and short-term survival examinations were later carried out in 3 cases by means of this method. Postoperative viability was assessed by angiography, methylene blue testing, and histology. Of the 3 transplanted grafts, 2 still survived 1 week after the operation. For technical reasons, 1 flap thrombotized. For determination of the viability of the transplanted graft, histology proved best. Vital reactions, including granulation tissue and angiogenesis, were present on the histological slides. The short-term survival of an omental flap can be ensured with microsurgical transplantation in dogs. Copyright 2003 Wiley-Liss, Inc.

Analyzing cell fate control by cytokines through continuous single cell biochemistry.

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Rieger, Michael A; Schroeder, Timm

2009-10-01

Cytokines are important regulators of cell fates with high clinical and commercial relevance. However, despite decades of intense academic and industrial research, it proved surprisingly difficult to describe the biological functions of cytokines in a precise and comprehensive manner. The exact analysis of cytokine biology is complicated by the fact that individual cytokines control many different cell fates and activate a multitude of intracellular signaling pathways. Moreover, although activating different molecular programs, different cytokines can be redundant in their biological effects. In addition, cytokines with different biological effects can activate overlapping signaling pathways. This prospect article will outline the necessity of continuous single cell biochemistry to unravel the biological functions of molecular cytokine signaling. It focuses on potentials and limitations of recent technical developments in fluorescent time-lapse imaging and single cell tracking allowing constant long-term observation of molecules and behavior of single cells. (c) 2009 Wiley-Liss, Inc.

Analysis of recent incidents of on-field violence in sport: legal decisions and additional considerations from psychology.

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Kerr, John H

2009-01-01

This article focuses on two recent incidents of serious on-field violence in sports and the legal consequences for those involved. The two incidents occurred in Dutch football (soccer) and became infamous owing to the nature of the violent incidents and widespread media coverage. The legal outcomes of these two incidents are described, and some of the difficulties that legal authorities face in considering assaults on the sports field are discussed. A new way of categorizing such violent incidents and the motivation behind them, based on an established psychological theory [reversal theory, Apter, 1982, 2001] is proposed. Taken along with the other points made in this article, being aware of when and how individuals cross the boundaries between play and anger, power or thrill violence may provide an additional perspective to making informed decisions about illegal violent acts on the sports field. Copyright 2008 Wiley-Liss, Inc.

Study on crystallization kinetics and phase evolution in Li2O-Al2O3-GeO2-P2O5 glass-ceramics system

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Das, Anurup; Dixit, Anupam; Goswami, Madhumita; Mythili, R.; Hajra, R. N.

2018-04-01

To address the safety issues related to liquid electrolyte and improve the battery performance, Solid State Electrolytes (SSEs) are now in frontier area of research interest. We report here synthesis of Li-SSE based on Li2O-Al2O3-GeO2-P2O5 (LAGP) system with NASICON structure. Glass sample with nominal composition Li1.5Al0.5Ge1.5P2.5Si0.5O12 was prepared by melt-quenching technique. Non-isothermal crystallization kinetics was studied using DSC and activation energy of crystallisation was calculated to be ˜ 246 kJ/mol using Kissinger's equation. XRD of heat treated samples show the formation of required LiGe2(PO4)3 phase along with other minor phases. Compositional analysis using SEM-EDX confirms enrichment of Ge and Si along the grain boundaries.

The critical main-chain length for helix formation in water: determined in a peptide series with alternating Aib and Ala residues exclusively and detected with ECD spectroscopy.

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Longo, Edoardo; Moretto, Alessandro; Formaggio, Fernando; Toniolo, Claudio

2011-10-01

Critical main-chain length for peptide helix formation in the crystal (solid) state and in organic solvents has been already reported. In this short communication, we describe our results aiming at assessing the aforementioned parameter in water solution. To this goal, we synthesized step-by-step by solution procedures a complete series of N-terminally acetylated, C-terminally methoxylated oligopeptides, characterized only by alternating Aib and Ala residues, from the dimer to the nonamer level. All these compounds were investigated by electronic circular dichroism in the far-UV region in water solution as a function of chemical structure, namely presence/absence of an ester moiety or a negative charge at the C-terminus, and temperature. We find that the critical main-chain lengths for 3(10)- and α-helices, although still formed to a limited extent, in aqueous solution are six and eight residues, respectively. © 2011 Wiley-Liss, Inc.

Measuring circular dichroism in a capillary cell using the b23 synchrotron radiation CD beamline at diamond light source.

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Jávorfi, Tamás; Hussain, Rohanah; Myatt, Daniel; Siligardi, Giuliano

2010-01-01

Synchrotron radiation circular dichroism (SRCD) is a well-established method in structural biology. The first UV-VIS beamline dedicated to circular dichroism at Diamond Light Source, a third generation synchrotron facility in South Oxfordshire, has recently become operational and it is now available for the user community. Herein we present an important application of SRCD: the CD measurement of protein solutions in fused silica rectangular capillary cells. This was achieved without the use of any lens between the photoelastic modulator and the photomultiplier tube detectors by exploiting the high photon flux of the collimated beam that can be as little as half a millimeter squared. Measures to minimize or eliminate vacuum-UV protein denaturation effects are discussed. The CD spectra measured in capillaries is a proof of principle to address CD measurements in microdevice systems using the new B23 SRCD beamline. © 2010 Wiley-Liss, Inc.

Laryngotracheal morphology of Afro-Madagascan geckos: a comparative survey.

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Russell, A P; Rittenhouse, D R; Bauer, A M

2000-09-01

The structural variation of the gekkonid larynx and trachea is examined within a representative subset of 17 species of Afro-Madagascan gekkonines to determine if there are underlying morphological correlates of vocalization. The documented morphology is compared to that of the tokay (Gekko gecko), which has previously been described. Data were obtained from gross anatomical observations, scanning electron microscopy, histological examinations and computer-generated, three-dimensional, skeletal reconstructions. Although there is limited variation among most Afro-Malagasy gekkonids, the larynges of Ptenopus garrulus and Uroplatus fimbriatus exhibit marked degrees of differentiation, suggesting that laryngeal and tracheal morphology may account for the documented vocal variability of gekkonid lizards. Cladistic analyses indicated that parallel adaptive trends characterize the laryngeal morphology of the examined taxa. Alternate designs and refinements to a model of gekkonid phonation are presented, and the evolution of acoustic communication in the Gekkonidae is considered. Copyright 2000 Wiley-Liss, Inc.

Review and update of mutations causing Waardenburg syndrome.

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Pingault, Véronique; Ente, Dorothée; Dastot-Le Moal, Florence; Goossens, Michel; Marlin, Sandrine; Bondurand, Nadège

2010-04-01

Waardenburg syndrome (WS) is characterized by the association of pigmentation abnormalities, including depigmented patches of the skin and hair, vivid blue eyes or heterochromia irides, and sensorineural hearing loss. However, other features such as dystopia canthorum, musculoskeletal abnormalities of the limbs, Hirschsprung disease, or neurological defects are found in subsets of patients and used for the clinical classification of WS. Six genes are involved in this syndrome: PAX3 (encoding the paired box 3 transcription factor), MITF (microphthalmia-associated transcription factor), EDN3 (endothelin 3), EDNRB (endothelin receptor type B), SOX10 (encoding the Sry bOX10 transcription factor), and SNAI2 (snail homolog 2), with different frequencies. In this review we provide an update on all WS genes and set up mutation databases, summarize molecular and functional data available for each of them, and discuss the applications in diagnostics and genetic counseling. (c) 2010 Wiley-Liss, Inc.

Distal 4p microdeletion in a case of Wolf-Hirschhorn syndrome with congenital diaphragmatic hernia.

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Casaccia, Germana; Mobili, Luisa; Braguglia, Annabella; Santoro, Francesco; Bagolan, Pietro

2006-03-01

Wolf-Hirschhorn syndrome (WHS) is a well-known genetic condition characterized by typical facial anomalies, midline defects, skeletal anomalies, prenatal and postnatal growth retardation, hypotonia, mental retardation, and seizures. Affected patients with a microdeletion on distal 4p present a milder phenotype that lacks congenital malformations. WHS is rarely associated with congenital diaphragmatic hernia (CDH), and only 8 cases are reported in the literature. In almost all cases of CDH and WHS a large deletion of the short arm of chromosome 4 is present. A microdeletion of 2.6 Mb on distal 4p associated with CDH and multiple congenital malformations (i.e., cleft palate) is reported for the first time. Such a microdeletion should prompt a molecular study for WHS when in a fetus/newborn with CDH the association with cleft lip/palate and typical facial appearance (flat facial profile, hypertelorism) is found. Copyright 2006 Wiley-Liss, Inc.

Life in the fast lane: high-throughput chemistry for lead generation and optimisation.

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Hunter, D

2001-01-01

The pharmaceutical industry has come under increasing pressure due to regulatory restrictions on the marketing and pricing of drugs, competition, and the escalating costs of developing new drugs. These forces can be addressed by the identification of novel targets, reductions in the development time of new drugs, and increased productivity. Emphasis has been placed on identifying and validating new targets and on lead generation: the response from industry has been very evident in genomics and high throughput screening, where new technologies have been applied, usually coupled with a high degree of automation. The combination of numerous new potential biological targets and the ability to screen large numbers of compounds against many of these targets has generated the need for large diverse compound collections. To address this requirement, high-throughput chemistry has become an integral part of the drug discovery process. Copyright 2002 Wiley-Liss, Inc.

Essential role for fibrillin-2 in zebrafish notochord and vascular morphogenesis.

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Gansner, John M; Madsen, Erik C; Mecham, Robert P; Gitlin, Jonathan D

2008-10-01

Recent studies demonstrate that lysyl oxidase cuproenzymes are critical for zebrafish notochord formation, but the molecular mechanisms of copper-dependent notochord morphogenesis are incompletely understood. We, therefore, conducted a forward genetic screen for zebrafish mutants that exhibit notochord sensitivity to lysyl oxidase inhibition, yielding a mutant with defects in notochord and vascular morphogenesis, puff daddygw1 (pfdgw1). Meiotic mapping and cloning reveal that the pfdgw1 phenotype results from disruption of the gene encoding the extracellular matrix protein fibrillin-2, and the spatiotemporal expression of fibrillin-2 is consistent with the pfdgw1 phenotype. Furthermore, each aspect of the pfdgw1 phenotype is recapitulated by morpholino knockdown of fibrillin-2. Taken together, the data reveal a genetic interaction between fibrillin-2 and the lysyl oxidases in notochord formation and demonstrate the importance of fibrillin-2 in specific early developmental processes in zebrafish. Copyright (c) 2008 Wiley-Liss, Inc.

Characterization of image heterogeneity using 2D Minkowski functionals increases the sensitivity of detection of a targeted MRI contrast agent.

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Canuto, Holly C; McLachlan, Charles; Kettunen, Mikko I; Velic, Marko; Krishnan, Anant S; Neves, Andre' A; de Backer, Maaike; Hu, D-E; Hobson, Michael P; Brindle, Kevin M

2009-05-01

A targeted Gd(3+)-based contrast agent has been developed that detects tumor cell death by binding to the phosphatidylserine (PS) exposed on the plasma membrane of dying cells. Although this agent has been used to detect tumor cell death in vivo, the differences in signal intensity between treated and untreated tumors was relatively small. As cell death is often spatially heterogeneous within tumors, we investigated whether an image analysis technique that parameterizes heterogeneity could be used to increase the sensitivity of detection of this targeted contrast agent. Two-dimensional (2D) Minkowski functionals (MFs) provided an automated and reliable method for parameterization of image heterogeneity, which does not require prior assumptions about the number of regions or features in the image, and were shown to increase the sensitivity of detection of the contrast agent as compared to simple signal intensity analysis. (c) 2009 Wiley-Liss, Inc.

Incidence of lung cancer among subway drivers in Stockholm.

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Gustavsson, Per; Bigert, Carolina; Pollán, Marina

2008-07-01

Very high levels of airborne particles have been detected in the subway system in Stockholm. Subway particles are more toxic to DNA in cultured human lung cells than particles from ambient air. This cohort comprised all men in Stockholm County who were gainfully employed in 1970. They were followed for cancer incidence until 1989. Lung cancer cases were identified from the national cancer register. Subway drivers were identified from the census in 1970. The reference cohort comprised all transport and communication workers in Stockholm. There were nine cases of lung cancer among the subway drivers, giving a SIR of 0.82 (95% confidence interval 0.38-1.56). The lung cancer incidence was not increased among the subway drivers. The study gives some evidence against the hypothesis that subway particles would be more potent in inducing lung cancer than particles in ambient air. (c) 2008 Wiley-Liss, Inc.

Structure of the posthepatic septum and its influence on visceral topology in the tegu lizard, Tupinambis merianae (Teiidae: Reptilia).

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Klein, Wilfried; Abe, Augusto S; Andrade, Denis V; Perry, Steven F

2003-11-01

The posthepatic septum (PHS) divides the body cavity of Tupinambis merianae into two parts: the cranial one containing the lungs and liver and the caudal one containing the remaining viscera. The PHS is composed of layers of collagenous fibers and bundles of smooth muscle, neither of which show systematic orientation, as well as isolated blood vessels, lymphatic vessels, and nerves. Striated muscle of the abdominal wall does not invade the PHS. The contractions of the smooth muscles may stabilize the pleurohepatic cavity under conditions of elevated aerobic needs rather than supporting breathing on a breath-by-breath basis. Surgical removal of the PHS changes the anatomical arrangement of the viscera significantly, with stomach and intestine invading the former pleurohepatic cavity and reducing the space for the lungs. Thus, the PHS is essential to maintain the visceral topography in Tupinambis. Copyright 2003 Wiley-Liss, Inc.

Being human and doing primatology: national, socioeconomic, and ethnic influences on primatological practice.

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Fuentes, Agustin

2011-03-01

The emerging manifesto, center of the essay collection this commentary is part of, points out that primatology is a primate's science and field of endeavor. It is about primates, and constructed and carried out by primates. But the relationships between different primates involved in primatology cannot be described merely as scientific, zoological, or conservatory. A main point emerging from this perspective is that the relationships amongst primates (as scientists and as subjects) are affected by primatologists' experiences outside of academic science and within the cultural schema that we acquire as members of human societies. My contribution focuses on the primatologists and their sometimes discussed, but too often ignored, cultural and ethnic contexts as influences on how they study, think about, and interact with other primates. In our views and bonds with other primates, do national, class, and ethnic factors count? 2010 Wiley-Liss, Inc.

Tapir (Tapirus) enteroliths

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Murphy, M.R.; Masters, J.M.; Moore, D.M.; Glass, H.D.; Hughes, R.E.; Crissey, S.D.

1997-01-01

Enterolith fragments from two tapir species and horses were subjected to x-ray diffraction analysis. Tapir enteroliths were formed as layers of mineral deposited around a foreign nidus. The structure was similar to that of equine enteroliths except that tapir enteroliths lacked a central region of radially symmetrical coarse crystals. The enteroliths from tapirs were composed primarily of vivianite [Fe3(PO4)2 ?? 8H2O] and newberyite [MgH(PO4) ?? 3H2O], instead of the struvite [Mg(NH4)(PO4) ?? 6H2O] of enteroliths from horses. The reason for this difference is not known. Based on the chemistry of these mineral precipitates and information from other species, it was concluded that dietary manipulation to maximize carbohydrate fermentation and minimize protein fermentation in the large intestine may help prevent enterolithiasis in tapirs. ?? 1997 Wiley-Liss, Inc.

Genetic disorders affecting white matter in the pediatric age.

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Di Rocco, Maja; Biancheri, Roberta; Rossi, Andrea; Filocamo, Mirella; Tortori-Donati, Paolo

2004-08-15

Pediatric white matter disorders can be distinguished into well-defined leukoencephalopathies, and undefined leukoencephalopathies. The first category may be subdivided into: (a) hypomyelinating disorders; (b) dysmyelinating disorders; (c) leukodystrophies; (d) disorders related to cystic degeneration of myelin; and (e) disorders secondary to axonal damage. The second category, representing up to 50% of leukoencephalopathies in childhood, requires a multidisciplinar approach in order to define novel homogeneous subgroups of patients, possibly representing "new genetic disorders" (such as megalencephalic leukoencepahlopathy with subcortical cysts and vanishing white matter disease that have recently been identified). In the majority of cases, pediatric white matter disorders are inherited diseases. An integrated description of the clinical, neuroimaging and pathophysiological features is crucial for categorizing myelin disorders and better understanding their genetic basis. A review of the genetic disorders affecting white matter in the pediatric age, including some novel entities, is provided. Copyright 2004 Wiley-Liss, Inc.

Comparative analysis of purified Pacific and Caribbean ciguatoxin congeners and related marine toxins using a modified ELISA technique.

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Campora, Cara E; Hokama, Y; Ebesu, Joanne S M

2006-01-01

The monoclonal antibody to ciguatoxin (CTX) produced from a hybridoma cell line was assayed for the detection of four congeners of CTX: Pacific ciguatoxin-1 (P-CTX-1), Pacific ciguatoxin-2 (P-CTX-2), Pacific ciguatoxin-3 (P-CTX-3), and Caribbean ciguatoxin-1 (C-CTX-1) and related marine toxins, including domoic acid, palytoxin, and okadaic acid, using a modified enzyme-linked immunosorbent assay (ELISA). Lower detection limits were assessed and linearity was statistically established (P<0.05) for P-CTX-1, P-CTX-2, and P-CTX-3 and C-CTX-1 at concentrations ranging from 0 to 5.00 ng, while the other marine toxins showed statistically insignificant cross-reactivities at similar concentrations. Thus, the monoclonal antibody to CTX is able to specifically detect various CTX congeners at levels comparable to those naturally occurring in ciguatoxic fish. (c) 2006 Wiley-Liss, Inc.

Comparison of liver mitochondrial proteins derived from newborn cloned calves and from cloned adult cattle by two-dimensional differential gel electrophoresis.

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Takeda, Kumiko; Tasai, Mariko; Akagi, Satoshi; Watanabe, Shinya; Oe, Mika; Chikuni, Koichi; Ohnishi-Kameyama, Mayumi; Hanada, Hirofumi; Nakamura, Yoshiaki; Tagami, Takahiro; Nirasawa, Keijiro

2011-04-01

Aberrant reprogramming of donor somatic cell nuclei may result in many severe problems in animal cloning. The inability to establish functional interactions between donor nucleus and recipient mitochondria is also likely responsible for such a developmental deficiency. However, detailed knowledge of protein expression during somatic cell nuclear transfer (SCNT) in cattle is lacking. In the present study, variations in mitochondrial protein levels between SCNT-derived and control cattle, and from calves derived by artificial insemination were investigated. Mitochondrial fractions were prepared from frozen liver samples and subjected to two-dimensional (2-D) fluorescence differential gel electrophoresis (DIGE) using CyDye™ dyes. Protein expression changes were confirmed with a volume ratio greater than 2.0 (P result implicates mitochondrial-related gene expression in early developmental loss of SCNT embryos. Comparative proteomic analysis represents an important tool for further studies on SCNT animals. Copyright © 2011 Wiley-Liss, Inc.

Transmitter release in the neuromuscular synapse of the protein kinase C theta-deficient adult mouse.

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Besalduch, Núria; Santafé, Manel M; Garcia, Neus; Gonzalez, Carmen; Tomás, Marta; Tomás, Josep; Lanuza, Maria A

2011-04-01

We studied structural and functional features of the neuromuscular junction in adult mice (P30) genetically deficient in the protein kinase C (PKC) theta isoform. Confocal and electron microscopy shows that there are no differences in the general morphology of the endplates between PKC theta-deficient and wild-type (WT) mice. Specifically, there is no difference in the density of the synaptic vesicles. However, the myelin sheath is not as thick in the intramuscular nerve fibers of the PKC theta-deficient mice. We found a significant reduction in the size of evoked endplate potentials and in the frequency of spontaneous, asynchronous, miniature endplate potentials in the PKC theta-deficient neuromuscular preparations in comparison with the WT, but the mean amplitude of the spontaneous potentials is not different. These changes indicate that PKC theta has a presynaptic role in the function of adult neuromuscular synapses. Copyright © 2010 Wiley-Liss, Inc.

NUTRITION 91e Congrès de l’AOCS : l’essentiel du programme nutrition (San Diego, 25-28 avril 2000

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Mendy François

2000-09-01

Full Text Available La densité du programme de la Division Health and Nutrition rendait cette fois très difficile le suivi même partiel du programme des autres divisions. Après l’impressionnante entrée en lice des functionnal foods et des nutraceuticals en 1999, il semble que la Division Health and Nutrition ait choisi de traiter de façon approfondie des thèmes importants. Les trois thèmes choisis cette année étaient : * L’acide gamma-linolénique : 22 communications auxquelles il faut sûrement ajouter les 5 communications d’une matinée sur « lipides bioactifs et transduction des signaux ». * Acide gras mono-insaturés versus polyinsaturés dans la gestion du risque de maladies cardio-vasculaires : Que devons-nous choisir ? 6 communications seulement, mais importantes, susceptibles d’avoir un gros impact et témoignant d’un vrai malaise. Selon la remarque de M. Bieber : « si ceci continue, que nous restera-t-il à dire ? ». * Lipides et désordres psychiatrique : 7 communications sur le thème de l’influence des acides gras polyinsaturés en n-3. Enfin la Division Health and Nutrition présentait 18 communications sur le thème Nutrition and General Health, son thème habituel. Parmi celles-ci, il faut relever deux Honored Student Award Winner français : S. Bellenger-Germain de l’équipe de J.-P. Poisson à Dijon, dont nous parlerons, et B. Nay de Bordeaux-II. Ceci ne s’était jamais produit jusqu’ici surtout si l’on ajoute le Herbert J. Dutton Award décerné par la Division analytique à J.-L. Sebedio. À ces 53 communications, il faut ajouter 36 posters pour la Nutrition and Health Division, soit 89 présentations au total. Pour terminer ce tour d’horizon, il faut signaler deux conférences remarquables sur des thèmes majeurs en nutrition lipidique : * celle du Stephen S. Chang Award de B. Herslof : From drug delivery to functionnal food. A lipid story; * celle du Supelco/Nicholas Research Award de H. Sprecher : The

L’infarctus du myocarde du jeune adulte -Analyse rétrospective des cas colligés au CHU de Dakar

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Nobila Valentin Yameogo

2010-09-01

Full Text Available Les données relatives à l’infarctus du myocarde chez le jeune adulte sont rares en Afrique noir. Nous rapportons une série rétrospective de 14 cas d’infarctus du myocarde chez l’adulte jeune noir africain. Pour analyser les caractéristiques épidémiologiques, cliniques, électriques, échographiques, biologiques, thérapeutiques et évolutives de l’infarctus aigu du myocarde chez le jeune adulte nous avons étudié de manière rétrospective les dossiers médicaux d’une série consécutive des patients admis entre Janvier 2003 et Décembre 2008 pour prise en charge d’infarctus aigu du myocarde. Quatre-vingt quatre (84 cas d’infarctus du myocarde ont été pris en charge durant la période d’étude ,14 patients (16,6% avaient un âge inférieur ou égal à 40 ans. L’âge moyen était de 34 +ou-5ans (extrêmes 27ans et 40 ans. Les facteurs de risque cardio-vasculaire étaient dominés par le sexe masculin (n=11, la dyslipidémie (n=7 et le tabagisme par cigarette (n=6. La contraception orale était absente chez le 1/3 des patients. Le délai moyen d’admission était tardif (15 plus ou moins 4 heures. L’IDM était antérieur dans la moitié des cas. L’acide acétylsalicylique, les inhibiteurs de l’enzyme de conversion Les bétabloquants et les statines étaient les médicaments les plus prescrits. La thrombolyse et l’angioplastie étaient respectivement réalisées chez 3 patients et 0 patient. 4 cas d’insuffisance cardiaque, 2 cas de bloc atrio-ventriculaire complet et 1 cas de décès étaient les principales complications. L’infarctus du myocarde concerne également le sujet jeune noir africain. Les facteurs de risque sont essentiellement représentés par le sexe, la dyslipidémie, le tabagisme et la contraception orale.

Les complications chirurgicales de la transplantation rénale à partir du donneur vivant: expérience du CHU Ibn Sina de Rabat

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Intissar Haddiya

2010-09-01

Full Text Available INTRODUCTION: La transplantation rénale (TR est actuellement considérée comme un traitement de choix de l’insuffisance rénale chronique terminale (IRCT. Ses résultats se sont améliorés au cours des dernières années. Cependant, les complications chirurgicales demeurent graves car elles touchent un rein unique et surviennent sur un terrain fragilisé par l’insuffisance rénale et l’immunosuppression. L’objectif de ce travail est d’évaluer la fréquence des complications chirurgicales lors de l’activité de TR au CHU Ibn Sina de Rabat, et de dégager les facteurs ayant influé l’apparition de ces complications. METHODES: Étude rétrospective des patients transplantés rénaux à partir de donneurs vivants apparentés (DVA de Juin 1999 à Décembre 2008 dans notre centre hospitalo-universitaire. Nous avons recensé les caractéristiques propres au receveur, au prélèvement, au donneur ainsi qu’au greffon. Les complications chirurgicales ont été colligées ainsi que leur prise en charge et évolution. RESULTATS: Soixante sept dossiers ont été analysés avec un suivi moyen de 55 +/- 28 mois. 38 complications chirurgicales ont été recensées : sténose des artères rénales (38,7%, lymphocèle (21%, hématome (12,7%, thrombose vasculaire (7,8%, reflux vésico-urétéral (4,8%, rupture du greffon (3,2%, calcul (1 cas, éventration (1 cas, L’analyse statistique de notre série n’a pas mis en évidence de facteurs de risque significatifs semblant influer sur l’incidence des complications chirurgicales. CONCLUSION: La morbidité liée aux complications chirurgicales de la TR reste élevée nécessitant un diagnostic et un traitement adéquat afin d’éviter les répercussions sur la survie des patients et des greffons.

Muscular fixing of the H.M.D.P. {sup 99m}Tc induced by a statin, rosuvastatin or crestor: clinical case; Fixation musculaire du HMDP Tc99m induite par une statine, la rosuvastatine ou Crestor: cas clinique

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Bourahla, K.; Hassler, S.; Schneegans, O.; Gyen, L.N. [CLCC Paul-Strauss, Service de medecine nucleaire, 67 - Strasbourg (France)

2010-07-01

Myositis induced by statins in treatment for hypercholesterolemia is a special clinical entity that may be encountered during an exploration by bone scintigraphy. We present the case of a muscle fixing observed in bone scan in a patient treated with rosuvastatin (Crestor). Muscular extra bone fixing of hydroxy-methane diphosphonate (H.M.D.P.) {sup 99m}T in patients referred for staging of prostate carcinoma, patients sometimes also treated for high cholesterol may be iatrogenic due to taking statins. A simple history may then allow its identification, although it remains asymptomatic. (N.C.)

Diagnostic pitfalls associated with fine-needle aspiration biopsy in a patient with the myxoid variant of monophasic fibrous synovial sarcoma.

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Bergman, Simon; Brownlee, Noel A; Geisinger, Kim R; Ward, William G; Pettenati, Mark J; Koty, Patrick; Ellis, Ezra; Beaty, Michael W; Kilpatrick, Scott E

2006-11-01

Synovial sarcoma (SS) is one of the most common soft tissue tumors that typically presents in the extremities of young adults, but may occur at any site and affect children during the first decade. Herein we discuss a 12-yr-old male who complained of left foot pain and plantar mass. A fine-needle aspiration biopsy of an 8 cm subcutaneous mass was performed revealing a myxoid spindle cell neoplasm. The cytologic differential diagnosis included a myxoid neurofibroma, neurothekeoma, and a myxoid sarcoma. Subsequent excision of the mass revealed a monophasic fibrous SS with myxoid features. Examination of the tissue by fluorescence in situ hybridization confirmed the presence of characteristic SS SYT gene rearrangement at chromosome 18q11.2. This case underscores that the cytologic distinction of mxyoid spindle cell tumors may be challenging. We report the cytologic features of a myxoid monophasic fibrous SS, and discuss its distinction from other benign and malignant myxoid soft tissue neoplasms. (C) 2006 Wiley-Liss, Inc.

The effect of genetic variation of the serotonin 1B receptor gene on impulsive aggressive behavior and suicide.

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Zouk, Hana; McGirr, Alexander; Lebel, Véronique; Benkelfat, Chawky; Rouleau, Guy; Turecki, Gustavo

2007-12-05

Impulsive-aggressive behaviors (IABs) are regarded as possible suicide intermediate phenotypes, mediating the relationship between genes and suicide outcome. In this study, we aimed to investigate the putative relationship between genetic variation at the 5-HT1B receptor gene, which in animal models is involved in impulse-aggression control, IABs, and suicide risk. We investigated the relationship of variation at five 5-HT1B loci and IAB measures in a sample of 696 subjects, including 338 individuals who died by suicide and 358 normal epidemiological controls. We found that variation at the 5-HT1B promoter A-161T locus had a significant effect on levels of IABs, as measured by the Buss-Durkee Hostility Inventory (BDHI). Suicides also differed from controls in distribution of variants at this locus. The A-161T locus, which seems to impact 5-HT1B transcription, could play a role in suicide predisposition by means of mediating impulsive-aggressive behaviors. 2007 Wiley-Liss, Inc.

Effects of hippocampal lesions on the monkey's ability to learn large sets of object-place associations.

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Belcher, Annabelle M; Harrington, Rebecca A; Malkova, Ludise; Mishkin, Mortimer

2006-01-01

Earlier studies found that recognition memory for object-place associations was impaired in patients with relatively selective hippocampal damage (Vargha-Khadem et al., Science 1997; 277:376-380), but was unaffected after selective hippocampal lesions in monkeys (Malkova and Mishkin, J Neurosci 2003; 23:1956-1965). A potentially important methodological difference between the two studies is that the patients were required to remember a set of 20 object-place associations for several minutes, whereas the monkeys had to remember only two such associations at a time, and only for a few seconds. To approximate more closely the task given to the patients, we trained monkeys on several successive sets of 10 object-place pairs each, with each set requiring learning across days. Despite the increased associative memory demands, monkeys given hippocampal lesions were unimpaired relative to their unoperated controls, suggesting that differences other than set size and memory duration underlie the different outcomes in the human and animal studies. (c) 2005 Wiley-Liss, Inc.

Sirenomelia and VACTERL association in the offspring of a woman with diabetes.

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Castori, Marco; Silvestri, Evelina; Cappellacci, Sandra; Binni, Francesco; Sforzolini, Giovanna Scassellati; Grammatico, Paola

2010-07-01

Sirenomelia and VACTERL association are defects of blastogenesis of unknown cause. Although they appear clinically distinct, some epidemiological and experimental studies suggest a common pathogenetic mechanism. We report on the reproductive history of a 28-year-old obese, diabetic mother who had three pregnancies. The first resulted in the birth of a sirenomelic child, the second in a miscarriage, while the third was terminated for fetal malformations, diagnosed post-mortem as VACTERL association. This observation supports the relationship between sirenomelia and VACTERL, which probably represent the two ends of the same phenotypic spectrum. Their occurrence in the same sibship also indicates a possible common cause. The coexistence with maternal diabetes seems more than a chance occurrence and the constellation of malformations observed in the present family may be explained as the pleiotropic effect of the same teratogenic agent interacting with genetic predisposition to diabetes and/or obesity. (c) 2010 Wiley-Liss, Inc.

Association between Protestant religiosity and obsessive-compulsive symptoms and cognitions.

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Abramowitz, Jonathan S; Deacon, Brett J; Woods, Carol M; Tolin, David F

2004-01-01

There is evidence that religion and other cultural influences are associated with the presentation of obsessive-compulsive symptoms, as well as beliefs and assumptions presumed to underlie the development and maintenance of these symptoms. We sought to further examine the relationship between Protestant religiosity and (1) various symptoms of obsessive-compulsive disorder (OCD) (e.g., checking, washing) and (2) OCD-related cognitions. Using self-report questionnaires, we compared differences in these OCD-related phenomena between highly religious Protestants, moderately religious Protestants, and atheist/agnostic participants drawn from an undergraduate sample. Highly religious versus moderately religious Protestants reported greater obsessional symptoms, compulsive washing, and beliefs about the importance of thoughts. Additionally, the highly religious evinced more obsessional symptoms, compulsive washing, intolerance for uncertainty, need to control thoughts, beliefs about the importance of thoughts, and inflated responsibility, compared to atheists/agnostics. Results are discussed in terms of the relationship between religion and OCD symptoms in the context of the cognitive-behavioral conceptualization of OCD. Copyright 2004 Wiley-Liss, Inc.

Extremity salvage with a free musculocutaneous latissimus dorsi flap and free tendon transfer after resection of a large congenital fibro sarcoma in a 15-week-old infant. A case report.

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Germann, G; Waag, K-L; Selle, B; Jester, A

2006-01-01

A case of complex microsurgical reconstruction of the dorsum of the foot, including tendon transfer following tumor resection, in a 15-week-old male infant is presented. After birth, a 5.5 x 4 cm large tumor was observed on the dorsum of the right foot. Biopsy showed a congenital malignant fibro sarcoma. After initial chemotherapy a radical excision of the tumor at the age of 14 weeks was followed. To cover the defect a musculocutaneous latissimus dorsi flap was taken, the cutaneous part being large enough to cover the defect. Extensor tendons were reconstructed with free tendon transplants. Amputation is usually indicated in these cases. To the best of our knowledge, microsurgical reconstruction in infants at this age with congenital malignant tumors has not yet been reported. The case shows that Plastic surgery can play an important role in pediatric oncology and should routinely be integrated into the multi-modal treatment concepts. (c) 2006 Wiley-Liss, Inc. Microsurgery, 2006.

Inhibition of phosphatidylcholine-specific phospholipase C prevents bone marrow stromal cell senescence in vitro.

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Sun, Chunhui; Wang, Nan; Huang, Jie; Xin, Jie; Peng, Fen; Ren, Yinshi; Zhang, Shangli; Miao, Junying

2009-10-01

Bone marrow stromal cells (BMSCs) can proliferate in vitro and can be transplanted for treating many kinds of diseases. However, BMSCs become senescent with long-term culture, which inhibits their application. To understand the mechanism underlying the senescence, we investigated the activity of phosphatidylcholine-specific phospholipase C (PC-PLC) and levels of integrin beta4, caveolin-1 and ROS with BMSC senescence. The activity of PC-PLC and levels of integrin beta4, caveolin-1 and ROS increased greatly during cell senescence. Selective inhibition of increased PC-PLC activity with D609 significantly decreased the number of senescence-associated beta galactosidase positive cells in BMSCs. Furthermore, D609 restored proliferation of BMSCs and their differentiation into adipocytes. Moreover, D609 suppressed the elevated levels of integrin beta4, caveolin-1 and ROS. The data suggest that PC-PLC is involved in senescence of BMSCs, and its function is associated with integrin beta4, caveolin-1 and ROS. (c) 2009 Wiley-Liss, Inc.

Permeabilization and recovery of the stratum corneum in vivo: the synergy of photomechanical waves and sodium lauryl sulfate.

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Lee, S; McAuliffe, D J; Kollias, N; Flotte, T J; Doukas, A G

2001-01-01

Photomechanical waves render the stratum corneum permeable and allow macromolecules to diffuse into the epidermis and dermis. The aim of this study was to investigate the combined action of photomechanical waves and sodium lauryl sulfate, an anionic surfactant, for transdermal delivery. A single photomechanical wave was applied to the skin of rats in the presence of sodium lauryl sulfate. The sodium lauryl sulfate solution was removed and aqueous solutions of rhodamine-B dextran (40 kDa molecular weight) were applied to the skin at time points 2, 30, and 60 minutes post-exposure. The presence of rhodamine-B dextran in the skin was measured by fluorescence emission spectroscopy in vivo and fluorescence microscopy of frozen biopsies. The use of sodium lauryl sulfate delayed the recovery of the stratum corneum barrier and extended the time available for the diffusion of dextran through it. The combination of photomechanical waves and surfactants can enhance transdermal drug delivery. Copyright 2001 Wiley-Liss, Inc.

Plant DNA sequences from feces: potential means for assessing diets of wild primates.

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Bradley, Brenda J; Stiller, Mathias; Doran-Sheehy, Diane M; Harris, Tara; Chapman, Colin A; Vigilant, Linda; Poinar, Hendrik

2007-06-01

Analyses of plant DNA in feces provides a promising, yet largely unexplored, means of documenting the diets of elusive primates. Here we demonstrate the promise and pitfalls of this approach using DNA extracted from fecal samples of wild western gorillas (Gorilla gorilla) and black and white colobus monkeys (Colobus guereza). From these DNA extracts we amplified, cloned, and sequenced small segments of chloroplast DNA (part of the rbcL gene) and plant nuclear DNA (ITS-2). The obtained sequences were compared to sequences generated from known plant samples and to those in GenBank to identify plant taxa in the feces. With further optimization, this method could provide a basic evaluation of minimum primate dietary diversity even when knowledge of local flora is limited. This approach may find application in studies characterizing the diets of poorly-known, unhabituated primate species or assaying consumer-resource relationships in an ecosystem. (c) 2007 Wiley-Liss, Inc.

Quantitative description of proton exchange processes between water and endogenous and exogenous agents for WEX, CEST, and APT experiments.

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Zhou, Jinyuan; Wilson, David A; Sun, Phillip Zhe; Klaus, Judith A; Van Zijl, Peter C M

2004-05-01

The proton exchange processes between water and solutes containing exchangeable protons have recently become of interest for monitoring pH effects, detecting cellular mobile proteins and peptides, and enhancing the detection sensitivity of various low-concentration endogenous and exogenous species. In this work, the analytic expressions for water exchange (WEX) filter spectroscopy, chemical exchange-dependent saturation transfer (CEST), and amide proton transfer (APT) experiments are derived by the use of Bloch equations with exchange terms. The effects of the initial states for the system, the difference between a steady state and a saturation state, and the relative contributions of the forward and backward exchange processes are discussed. The theory, in combination with numerical calculations, provides a useful tool for designing experimental schemes and assessing magnetization transfer (MT) processes between water protons and solvent-exchangeable protons. As an example, the case of endogenous amide proton exchange in the rat brain at 4.7 T is analyzed in detail. Copyright 2004 Wiley-Liss, Inc.

Contribution of cellular retinol-binding protein type 1 to retinol metabolism during mouse development.

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Matt, Nicolas; Schmidt, Carsten K; Dupé, Valérie; Dennefeld, Christine; Nau, Heinz; Chambon, Pierre; Mark, Manuel; Ghyselinck, Norbert B

2005-05-01

Within cells, retinol (ROL) is bound to cytoplasmic proteins (cellular retinol-binding proteins [CRBPs]), whose proposed function is to protect it from unspecific enzymes through channeling to retinoid-metabolizing pathways. We show that, during development, ROL and retinyl ester levels are decreased in CRBP type 1 (CRBP1) -deficient embryos and fetuses by 50% and 80%, respectively. The steady state level of retinoic acid (RA) is also decreased but to a lesser extent. However, CRBP1-null fetuses do not exhibit the abnormalities characteristic of a vitamin A-deficiency syndrome. Neither CRBP1 deficiency alters the expression patterns of RA-responding genes during development, nor does CRBP1 availability modify the expression of an RA-dependent gene in primary embryonic fibroblasts treated with ROL. Therefore, CRBP1 is required in prenatal life to maintain normal amounts of ROL and to ensure its efficient storage but seems of secondary importance for RA synthesis, at least under conditions of maternal vitamin A sufficiency. Copyright 2005 Wiley-Liss, Inc.

Histological analysis of the alterations on cortical bone channels network after radiotherapy: A rabbit study.

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Rabelo, Gustavo Davi; Beletti, Marcelo Emílio; Dechichi, Paula

2010-10-01

The aim of this study was to evaluate the effects of radiotherapy in cortical bone channels network. Fourteen rabbits were divided in two groups and test group received single dose of 15 Gy cobalt-60 radiation in tibia, bilaterally. The animals were sacrificed and a segment of tibia was removed and histologically processed. Histological images were taken and had their bone channels segmented and called regions of interest (ROI). Images were analyzed through developed algorithms using the SCILAB mathematical environment, getting percentage of bone matrix, ROI areas, ROI perimeters, their standard deviations and Lacunarity. The osteocytes and empty lacunae were also counted. Data were evaluated using Kolmogorov-Smirnov, Mann Whitney, and Student's t test (P < 0.05). Significant differences in bone matrix percentage, area and perimeters of the channels, their respective standard deviations and lacunarity were found between groups. In conclusion, the radiotherapy causes reduction of bone matrix and modifies the morphology of bone channels network. © 2010 Wiley-Liss, Inc.

F-actin-based Ca signaling-a critical comparison with the current concept of Ca signaling.

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Lange, Klaus; Gartzke, Joachim

2006-11-01

A short comparative survey on the current idea of Ca signaling and the alternative concept of F-actin-based Ca signaling is given. The two hypotheses differ in one central aspect, the mechanism of Ca storage. The current theory rests on the assumption of Ca-accumulating endoplasmic/sarcoplasmic reticulum-derived vesicles equipped with an ATP-dependent Ca pump and IP3- or ryanodine-sensitive channel-receptors for Ca-release. The alternative hypothesis proceeds from the idea of Ca storage at the high-affinity binding sites of actin filaments. Cellular sites of F-actin-based Ca storage are microvilli and the submembrane cytoskeleton. Several specific features of Ca signaling such as store-channel coupling, quantal Ca release, spiking and oscillations, biphasic and "phasic" uptake kinetics, and Ca-induced Ca release (CICR), which are not adequately described by the current concept, are inherent properties of the F-actin system and its dynamic state of treadmilling. Copyright 2006 Wiley-Liss, Inc.

Incidence of workers compensation indemnity claims across socio-demographic and job characteristics.

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Du, Juan; Leigh, J Paul

2011-10-01

We hypothesized that low socioeconomic status, employer-provided health insurance, low wages, and overtime were predictors of reporting workers compensation indemnity claims. We also tested for gender and race disparities. Responses from 17,190 (person-years) Americans participating in the Panel Study of Income Dynamics, 1997-2005, were analyzed with logistic regressions. The dependent variable indicated whether the subject collected benefits from a claim. Odds ratios for men and African-Americans were relatively large and strongly significant predictors of claims; significance for Hispanics was moderate and confounded by education. Odds ratios for variables measuring education were the largest for all statistically significant covariates. Neither low wages nor employer-provided health insurance was a consistent predictor. Due to confounding from the "not salaried" variable, overtime was not a consistently significant predictor. Few studies use nationally representative longitudinal data to consider which demographic and job characteristics predict reporting workers compensation indemnity cases. This study did and tested some common hypotheses about predictors. Copyright © 2011 Wiley-Liss, Inc.

Sex differences in relational and overt aggression in the late elementary school years.

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Kistner, Janet; Counts-Allan, Carla; Dunkel, Stephanie; Drew, Catherine Hardee; David-Ferdon, Corinne; Lopez, Cristina

2010-01-01

Sex differences in relational and overt aggression among 3rd (n=176), 4th (n=179), and 5th graders (n=145) from three public schools (n=500; 278 girls) were examined. Nominations of relational aggression increased over time among 4th and 5th grade girls, but not among boys or 3rd grade girls. Among 3rd graders, boys received more nominations for relational aggression than girls. By the end of the 5th grade, girls received more relational aggression nominations than boys. There was also a significant rise in nominations of overt aggression among 5th grade girls, but not among 5th grade boys or younger boys and girls. As expected, boys were more likely than girls to be nominated for overt aggression at all grade levels. The findings are helpful for explaining inconsistencies of earlier research pertaining to sex differences in relational aggression and for advancing our understanding of the causes of aggression. (c) 2010 Wiley-Liss, Inc.

Adolescent perceptions of indirect forms of relational aggression: sex of perpetrator effects.

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Coyne, Sarah M; Archer, John; Eslea, Mike; Liechty, Toni

2008-01-01

Different types of aggressive behavior (both physical and relational) by boys and girls have been shown to be perceived differently by observers. However, most research has focused on adult perceptions of very young children, with little research examining other ages. The aim of this study is to establish any sex differences in adolescent perceptions of indirect forms of relational aggression enacted by boys and girls. One hundred and sixty adolescents were shown one of the two videos involving relational aggression and completed a questionnaire that assessed their perceptions of the aggression. The videos were identical except for the sex of the aggressor and the victim; one condition portrayed boy-to-boy aggression, the other showed girl-to-girl aggression. Results indicated that participants viewed boy-to-boy relational aggression as more justified. This study revealed that stereotypes about aggressive boys are perpetuated even when the aggression is a type that is not commonly associated with boys. 2008 Wiley-Liss, Inc.

Behavioral and social cognitive processes in preschool children's social dominance.

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Pellegrini, Anthony D; Van Ryzin, Mark J; Roseth, Cary; Bohn-Gettler, Catherine; Dupuis, Danielle; Hickey, Meghan; Peshkam, Annie

2011-01-01

This longitudinal, naturalistic study addressed behavioral and social cognitive processes implicated in preschool children's social dominance. In the first objective, we examined the degree to which peer aggression, affiliation, and postaggression reconciliation predicted social dominance across a school year. Consistent with predictions, all three predicted dominance early in the year while only affiliation predicted dominance later in the year, suggesting that aggression, affiliation, and reconciliation were used to establish social dominance where affiliation was used to maintain it. In the second, exploratory, objective we tested the relative importance of social dominance and reconciliation (the Machiavellian and Vygotskian intelligence hypotheses, respectively) in predicting theory of mind/false belief. Results indicated that social dominance accounted for significant variance, beyond that related to reconciliation and affiliation, in predicting theory of mind/false belief status. Results are discussed in terms of specific behavioral and social cognitive processes employed in establishing and maintaining social dominance. © 2011 Wiley-Liss, Inc.

Neural plasticity of development and learning.

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Galván, Adriana

2010-06-01

Development and learning are powerful agents of change across the lifespan that induce robust structural and functional plasticity in neural systems. An unresolved question in developmental cognitive neuroscience is whether development and learning share the same neural mechanisms associated with experience-related neural plasticity. In this article, I outline the conceptual and practical challenges of this question, review insights gleaned from adult studies, and describe recent strides toward examining this topic across development using neuroimaging methods. I suggest that development and learning are not two completely separate constructs and instead, that they exist on a continuum. While progressive and regressive changes are central to both, the behavioral consequences associated with these changes are closely tied to the existing neural architecture of maturity of the system. Eventually, a deeper, more mechanistic understanding of neural plasticity will shed light on behavioral changes across development and, more broadly, about the underlying neural basis of cognition. (c) 2010 Wiley-Liss, Inc.

Denaturing of single electrospun fibrinogen fibers studied by deep ultraviolet fluorescence microscopy.

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Kim, Jeongyong; Song, Hugeun; Park, Inho; Carlisle, Christine R; Bonin, Keith; Guthold, Martin

2011-03-01

Deep ultraviolet (DUV) microscopy is a fluorescence microscopy technique to image unlabeled proteins via the native fluorescence of some of their amino acids. We constructed a DUV fluorescence microscope, capable of 280 nm wavelength excitation by modifying an inverted optical microscope. Moreover, we integrated a nanomanipulator-controlled micropipette into this instrument for precise delivery of picoliter amounts of fluid to selected regions of the sample. In proof-of-principle experiments, we used this instrument to study, in situ, the effect of a denaturing agent on the autofluorescence intensity of single, unlabeled, electrospun fibrinogen nanofibers. Autofluorescence emission from the nanofibers was excited at 280 nm and detected at ∼350 nm. A denaturant solution was discretely applied to small, select sections of the nanofibers and a clear local reduction in autofluorescence intensity was observed. This reduction is attributed to the dissolution of the fibers and the unfolding of proteins in the fibers. Copyright © 2010 Wiley-Liss, Inc.

The theropod furcula.

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Nesbitt, Sterling J; Turner, Alan H; Spaulding, Michelle; Conrad, Jack L; Norell, Mark A

2009-07-01

The furcula is a structure formed by the midline fusion of the clavicles. This is the element which is unique to theropods and is important for understanding the link between birds and other theropods. New specimens from basal theropods suggest that the furcula appeared very early in theropod history. We review furcula development, function, and morphology, as well as the anatomical terminology applied to it. Furcular morphology is highly variable in crown-group avians but is rather conserved among nonavian theropods. Here we review, or describe for the first time, the furculae in many nonavian theropods. Furculae occur in nearly all major clades of theropods, as shown by new theropod specimens from the Early Cretaceous of China and a close inspection of previously collected specimens. Informative phylogenetic characters pertaining to the furcula occur throughout Theropoda, though care should betake to consider taphonomic effects when describing furcular morphology. (c) 2009 Wiley-Liss, Inc.

Modified expression of cytoplasmic isocitrate dehydrogenase electrophoretic isoforms in seminal plasma of men with sertoli-cell-only syndrome and seminoma.

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Starita-Geribaldi, Mireille; Samson, Michel; Guigonis, Jean-Marie; Pointis, Georges; Fenichel, Patrick

2008-06-01

Two isoforms of human cytoplasmic isocitrate dehydrogenase (IDPc) of close molecular weights and different isoelectric points were identified in human seminal plasma (SP) by two-dimensional gel electrophoresis (2-DE) followed by mass spectrometry (MS). These two isoforms were detected in the normospermic men SP and their expressions were markedly altered in patients with testicular seminoma, the most frequent testicular germ cell cancer (TGCC): increase of the more acidic spot and decrease of the more basic one. Since oligospermia has been considered as a high risk pathological condition for developing a testicular cancer, the two IDPc isoforms were analyzed in SP of a group of secretory azoospermic patients. In this group the two spots displayed similar variations of expression to those observed in testicular seminoma. These results propose IDPc as a promising SP biomarker of testicular seminoma. Whether IDPc alteration in secretory azoospermia is predictive of testicular seminoma remains to be elucidated. (c) 2007 Wiley-Liss, Inc.

The G-protein-coupled receptor, GPR84, is important for eye development in Xenopus laevis.

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Perry, Kimberly J; Johnson, Verity R; Malloch, Erica L; Fukui, Lisa; Wever, Jason; Thomas, Alvin G; Hamilton, Paul W; Henry, Jonathan J

2010-11-01

G-protein-coupled receptors (GPCRs) represent diverse, multifamily groups of cell signaling receptors involved in many cellular processes. We identified Xenopus laevis GPR84 as a member of the A18 subfamily of GPCRs. During development, GPR84 is detected in the embryonic lens placode, differentiating lens fiber cells, retina, and cornea. Anti-sense morpholino oligonucleotide-mediated knockdown and RNA rescue experiments demonstrate GPR84's importance in lens, cornea, and retinal development. Examination of cell proliferation using an antibody against histone H3 S10P reveals significant increases in the lens and retina following GPR84 knockdown. Additionally, there was also an increase in apoptosis in the retina and lens, as revealed by TUNEL assay. Reciprocal transplantation of the presumptive lens ectoderm between uninjected controls and morpholino-injected embryos demonstrates that GPR84 is necessary in the retina for proper development of the retina, as well as other eye tissues including the lens and cornea. © 2010 Wiley-Liss, Inc.

Embryonic expression of zebrafish MiT family genes tfe3b, tfeb, and tfec.

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Lister, James A; Lane, Brandon M; Nguyen, Anhthu; Lunney, Katherine

2011-11-01

The MiT family comprises four genes in mammals: Mitf, Tfe3, Tfeb, and Tfec, which encode transcription factors of the basic-helix-loop-helix/leucine zipper class. Mitf is well-known for its essential role in the development of melanocytes, however the functions of the other members of this family, and of interactions between them, are less well understood. We have now characterized the complete set of MiT genes from zebrafish, which totals six instead of four. The zebrafish genome contain two mitf (mitfa and mitfb), two tfe3 (tfe3a and tfe3b), and single tfeb and tfec genes; this distribution is shared with other teleosts. We present here the sequence and embryonic expression patterns for the zebrafish tfe3b, tfeb, and tfec genes, and identify a new isoform of tfe3a. These findings will assist in elucidating the roles of the MiT gene family over the course of vertebrate evolution. Copyright © 2011 Wiley-Liss, Inc.

Social learning of diet and foraging skills by wild immature Bornean orangutans: implications for culture.

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Jaeggi, Adrian V; Dunkel, Lynda P; Van Noordwijk, Maria A; Wich, Serge A; Sura, Agnes A L; Van Schaik, Carel P

2010-01-01

Studies of social learning in the wild are important to complement findings from experiments in captivity. In this field study, immature Bornean orangutans rarely foraged independently but consistently followed their mothers' choices. Their diets were essentially identical to their mothers' even though not all mothers had the same diet. This suggests vertical transmission of diet by enhancement. Also, immatures selectively observed their mothers during extractive foraging, which increased goal-directed practice but not general manipulation of similar objects, suggesting observational forms of learning of complex skills. Teaching was not observed. These results are consistent with the reported presence of food traditions and skill cultures in wild orangutans. We suggest that food traditions can develop wherever association commonly allows for social learning. However, the capacity for observational learning, and thus more complex culture, is more likely to evolve among extractive foragers with prolonged association between adults and immatures. (c) 2009 Wiley-Liss, Inc.

Radiofrequency exposure on fast patrol boats in the Royal Norwegian Navy--an approach to a dose assessment.

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Baste, Valborg; Mild, Kjell Hansson; Moen, Bente E

2010-07-01

Epidemiological studies related to radiofrequency (RF) electromagnetic fields (EMF) have mainly used crude proxies for exposure, such as job titles, distance to, or use of different equipment emitting RF EMF. The Royal Norwegian Navy (RNoN) has measured RF field emitted from high-frequency antennas and radars on several spots where the crew would most likely be located aboard fast patrol boats (FPB). These boats are small, with short distance between the crew and the equipment emitting RF field. We have described the measured RF exposure aboard FPB and suggested different methods for calculations of total exposure and annual dose. Linear and spatial average in addition to percentage of ICNIRP and squared deviation of ICNIRP has been used. The methods will form the basis of a job exposure matrix where relative differences in exposure between groups of crew members can be used in further epidemiological studies of reproductive health. 2010 Wiley-Liss, Inc.