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Sample records for musculaires lisses vasculaires

  1. Les effets musculaires de la vitamine D : application à la perte musculaire liée à l’âge

    Directory of Open Access Journals (Sweden)

    Walrand Stéphane

    2014-05-01

    Full Text Available Au-delà de ses rôles biologiques classiques sur la santé osseuse, les effets extra-squelettiques de la vitamine D font actuellement l’objet de nombreuses recherches. La présence du récepteur de la vitamine D dans la plupart des tissus de l’organisme vient d’ailleurs renforcer l’argument en faveur de ses fonctions multiples. Parmi celles-ci, l’effet de la vitamine D sur la masse et les performances musculaires a été longtemps pressenti. En effet, dans la Grèce Antique, Hérodote recommandait le soleil comme un remède pour les « muscles faibles et mous », et les anciens Olympiens recevaient l’ordre de se coucher exposés aux rayons du soleil pour améliorer leurs performances physiques. En 1952, Spellerberg, un physiologiste du sport, a réalisé une vaste étude portant sur les effets de l’irradiation UV sur les performances d’athlètes de haut niveau. Suite aux résultats positifs de cette investigation, ce scientifique dû informer le Comité Olympique que l’irradiation UV présentait un effet « convaincant » sur la performance physique et les capacités motrices. Ces données sont conformes à de nombreuses études postérieures signalant une amélioration des aptitudes physiques, de la vitesse et de l’endurance chez des sujets jeunes traités par des UV ou par des suppléments contenant de la vitamine D. Des observations complémentaires font état d’un effet significatif sur la force musculaire, en particulier au niveau des membres inférieurs. Concernant les mécanismes mis en jeu, certaines études fondamentales récentes ont montré que la vitamine D exerce des effets moléculaires au sein de la cellule musculaire. Précisément, une action régulatrice de la vitamine D sur les flux de calcium, l’homéostasie minérale et certaines voies de signalisation contrôlant l’anabolisme protéique a été rapportée au niveau du tissu musculaire. Plusieurs enquêtes épidémiologiques révèlent qu

  2. Comparison of citrus orchard inventory using LISS-III and LISS-IV data

    Science.gov (United States)

    Singh, Niti; Chaudhari, K. N.; Manjunath, K. R.

    2016-04-01

    In India, in terms of area under cultivation, citrus is the third most cultivated fruit crop after Banana and Mango. Among citrus group, lime is one of the most important horticultural crops in India as the demand for its consumption is very high. Hence, preparing citrus crop inventories using remote sensing techniques would help in maintaining a record of its area and production statistics. This study shows how accurately citrus orchard can be classified using both IRS Resourcesat-2 LISS-III and LISS-IV data and depicts the optimum bio-widow for procuring satellite data to achieve high classification accuracy required for maintaining inventory of crop. Findings of the study show classification accuracy increased from 55% (using LISS-III) to 77% (using LISS-IV). Also, according to classified outputs and NDVI values obtained, April and May months were identified as optimum bio-window for citrus crop identification.

  3. Propriétés contractiles des fibres musculaires et performance physique chez le cheval

    OpenAIRE

    Barrey, Eric

    1994-01-01

    Cet article présente les connaissances acquises sur la physiologie des fibres musculaires en relation avec l’exercice physique chez le cheval-athlète. La vitesse et la force de contraction développée par un muscle dépendent à la fois de la quantité de fibres actives et de leurs propriétés contractiles. Le muscle étant le moteur de l’athlète, de nombreuses études de physiologie de l’exercice ont porté sur la typologie musculaire afin d’en connaître le déterminisme et les potentialités adaptati...

  4. Banana orchard inventory using IRS LISS sensors

    Science.gov (United States)

    Nishant, Nilay; Upadhayay, Gargi; Vyas, S. P.; Manjunath, K. R.

    2016-04-01

    Banana is one of the major crops of India with increasing export potential. It is important to estimate the production and acreage of the crop. Thus, the present study was carried out to evolve a suitable methodology for estimating banana acreage. Area estimation methodology was devised around the fact that unlike other crops, the time of plantation of banana is different for different farmers as per their local practices or conditions. Thus in order to capture the peak signatures, biowindow of 6 months was considered, its NDVI pattern studied and the optimum two months were considered when banana could be distinguished from other competing crops. The final area of banana for the particular growing cycle was computed by integrating the areas of these two months using LISS III data with spatial resolution of 23m. Estimated banana acreage in the three districts were 11857Ha, 15202ha and 11373Ha for Bharuch, Anand and Vadodara respectively with corresponding accuracy of 91.8%, 90% and 88.16%. Study further compared the use of LISS IV data of 5.8m spatial resolution for estimation of banana using object based as well as per-pixel classification and the results were compared with statistical reports for both the approaches. In the current paper we depict the various methodologies to accurately estimate the banana acreage.

  5. Quasi-lisse vertex algebras and modular linear differential equations

    CERN Document Server

    Arakawa, Tomoyuki

    2016-01-01

    We introduce a notion of quasi-lisse vertex algebras, which generalizes admissible affine vertex algebras. We show that the normalized character of an ordinary module over a quasi-lisse vertex operator algebra has a modular invariance property, in the sense that it satisfies a modular linear differential equation. As an application we obtain the explicit character formulas of simple affine vertex algebras associated with the Deligne exceptional series at level $-h^{\\vee}/6-1$, which expresses the homogeneous Schur limit of the superconformal index of 4d SCFTs studied by Beem, Lemos, Liendo, Peelaers, Rastelli and van Rees, as quasi-modular forms.

  6. Reverse LISS plating for intertrochanteric Hip Fractures in elderly patients

    Directory of Open Access Journals (Sweden)

    Chen SB

    2010-07-01

    Full Text Available Abstract Background Fractures of the intertrochanteric hip are common and the treatment of unstable fractures generally requires an operative approach. In elderly patients, osteoporosis makes internal fixation problematic and frequently contributes to failed fixation and poor clinical results. We have attempted to apply the Less Invasive Stabilization System (LISS in reverse position for the repair of intertrochanteric hip fractures in elderly patients with osteoporotic bones. A retrospective review is presented of the cases of 28 elderly patients with stable and unstable fractures of the intertrochanteric hip treated using the reverse LISS. Methods We treated 28 elderly patients with a mean age of 82.3 years. According to the Evens classification, there were 2 Type I fractures, 2 Type II fractures, 3 Type III fractures, 13 Type IV fractures, 6 Type V fractures and 2 Type R fractures. All fractures were treated using the reverse LISS. Radiographic and clinical evidence of functional outcome and complications were evaluated. Results Mean perioperative blood loss was 92.4 milliliters (range 35 to 245 milliliters, and the mean postoperative hospital stay was 8.7 days (range 3 to 14 days. Complications included one minor wound hematoma. Radiographically, no collapses, screw cutouts, or head penetrations were seen. All surviving patients (28 of 28; 100 percent had uneventful fracture healing with union achieved by six months in all patients. Conclusions Use of the Reverse LISS plating for intertrochanteric hip fractures resulted in event-free fracture healing.

  7. Rain-induced subsurface airflow and Lisse effect

    Science.gov (United States)

    Guo, H.; Jiao, J.J.; Weeks, E.P.

    2008-01-01

    Water-level increase after rainfall is usually indicative of rainfall recharge to groundwater. This, however, may not be true if the Lisse effect occurs. This effect represents the water-level increase in a well driven by airflow induced by an advancing wetting front during highly intensive rains. The rainwater, which may behave like a low-permeability lid, seals the ground surface so that the air pressure beneath the wetting front is increased because of air compression due to downward movement of the wetting front. A rapid and substantial rise of the water level in the well screened below water table, which bears no relationship to groundwater recharge, can be induced when various factors such as soil properties and the rain-runoff condition combine favorably. A transient, three-dimensional and variably saturated flow model was employed to study the air and groundwater flows in the soil under rain conditions. The objectives of this paper are two-fold: to evaluate the reliability of the theory of the Lisse effect presented by Weeks to predict its magnitude in modeled situations that mimic the physical complexity of real aquifers, and to conduct parametric studies on the sensitivity of the water-level rise in the well to soil properties and the rain event. The simulation results reveal that the magnitude of the Lisse effect increases with the ponding depth. Soil permeability plays a key role in generating the Lisse effect. The water-level rise in the well is delayed relative to the air-pressure rise in the unsaturated zone when the soil permeability is low, and the maximum water-level rise is less than the maximum air pressure induced by rain infiltration. The simulation also explores the sensitivity of the Lisse effect to the van Genuchten parameters and the water table depth. Copyright 2008 by the American Geophysical Union.

  8. Epuisement du capital vasculaire en hémodialyse: quelle issue?

    Science.gov (United States)

    Hajji, Meriam; Harzallah, Amel; Kaaroud, Hayet; Jerbi, Mona; Chargui, Soumaya; Younsi, Fethi El; Hamida, Fethi Ben; abdallah, Taieb Ben

    2016-01-01

    Malgré les progrès réalisés dans le traitement de l’insuffisance rénale chronique, l’accès vasculaire reste le maillon faible dans la thérapie de suppléance extrarénale et la principale source de morbidité chez les patients hémodialysés. Nous rapportons l’observation d’une jeune patiente ayant une insuffisance rénale chronique secondaire à une néphropathie vasculaire en hémodialyse périodique, confrontée précocement à un épuisement de son capital vasculaire, en raison de thromboses itératives des fistules artério-veineuses et l’échec de la dialyse péritonéale. Un déficit en protéine C a été objectivé. Elle a bénéficié de la mise en place d’un cathéter tunnelisé au niveau de l’oreillette droite par thoracotomie antéro-latérale droite à travers la veine cave inférieure non fonctionnel au bout de trois mois de son utilisation. Elle est depuis dialysée par ponction des veines jugulaires externes. PMID:28293353

  9. Classification of Liss IV Imagery Using Decision Tree Methods

    Science.gov (United States)

    Verma, Amit Kumar; Garg, P. K.; Prasad, K. S. Hari; Dadhwal, V. K.

    2016-06-01

    Image classification is a compulsory step in any remote sensing research. Classification uses the spectral information represented by the digital numbers in one or more spectral bands and attempts to classify each individual pixel based on this spectral information. Crop classification is the main concern of remote sensing applications for developing sustainable agriculture system. Vegetation indices computed from satellite images gives a good indication of the presence of vegetation. It is an indicator that describes the greenness, density and health of vegetation. Texture is also an important characteristics which is used to identifying objects or region of interest is an image. This paper illustrate the use of decision tree method to classify the land in to crop land and non-crop land and to classify different crops. In this paper we evaluate the possibility of crop classification using an integrated approach methods based on texture property with different vegetation indices for single date LISS IV sensor 5.8 meter high spatial resolution data. Eleven vegetation indices (NDVI, DVI, GEMI, GNDVI, MSAVI2, NDWI, NG, NR, NNIR, OSAVI and VI green) has been generated using green, red and NIR band and then image is classified using decision tree method. The other approach is used integration of texture feature (mean, variance, kurtosis and skewness) with these vegetation indices. A comparison has been done between these two methods. The results indicate that inclusion of textural feature with vegetation indices can be effectively implemented to produce classifiedmaps with 8.33% higher accuracy for Indian satellite IRS-P6, LISS IV sensor images.

  10. CLASSIFICATION OF LISS IV IMAGERY USING DECISION TREE METHODS

    Directory of Open Access Journals (Sweden)

    A. K. Verma

    2016-06-01

    Full Text Available Image classification is a compulsory step in any remote sensing research. Classification uses the spectral information represented by the digital numbers in one or more spectral bands and attempts to classify each individual pixel based on this spectral information. Crop classification is the main concern of remote sensing applications for developing sustainable agriculture system. Vegetation indices computed from satellite images gives a good indication of the presence of vegetation. It is an indicator that describes the greenness, density and health of vegetation. Texture is also an important characteristics which is used to identifying objects or region of interest is an image. This paper illustrate the use of decision tree method to classify the land in to crop land and non-crop land and to classify different crops. In this paper we evaluate the possibility of crop classification using an integrated approach methods based on texture property with different vegetation indices for single date LISS IV sensor 5.8 meter high spatial resolution data. Eleven vegetation indices (NDVI, DVI, GEMI, GNDVI, MSAVI2, NDWI, NG, NR, NNIR, OSAVI and VI green has been generated using green, red and NIR band and then image is classified using decision tree method. The other approach is used integration of texture feature (mean, variance, kurtosis and skewness with these vegetation indices. A comparison has been done between these two methods. The results indicate that inclusion of textural feature with vegetation indices can be effectively implemented to produce classifiedmaps with 8.33% higher accuracy for Indian satellite IRS-P6, LISS IV sensor images.

  11. Epaisseur de l'intima-média carotidienne et facteurs de risque cardio-vasculaires

    Science.gov (United States)

    Herinirina, Nicolas Fanantenana; Rajaonarison, Lova Hasina Ny Ony Narindra; Herijoelison, Andry Roussel; Ahmad, Ahmad

    2015-01-01

    Introduction L’épaisseur intima-média de la carotide commune mesurée à l’échographie est un marqueur de risque cardio-vasculaire. L'objectif de ce travail est d’établir la corrélation entre l’épaisseur de l'intima-média carotidienne commune et les facteurs de risque cardio-vasculaire chez des sujets asymptomatiques. Méthodes Etude transversale descriptive et analytique portant sur 77 sujets de 40 ans et plus chez qui nous avons évalué les facteurs de risque cardio-vasculaire et analysé leur association avec l’épaisseur intima-média carotidienne commune. Résultats L’épaisseur intima-média augmentait avec l’âge. Les hommes avaient une épaisseur intima-média plus marquée que les femmes. L'hypertension artérielle, le diabète et la dyslipidémie sont corrélés à l’épaisseur de l'intima-média contrairement au tabagisme. Conclusion L’âge élevé et le sexe masculin sont les facteurs déterminants de la majoration de l’épaisseur intima-média carotidienne commune surtout si s'ajoutent l'hypertension artérielle, le diabète ou la dyslipidémie. PMID:26327990

  12. Inter sensor comparison between RESOURCESAT LISS III, LISS IV and AWiFS with reference to coastal landuse/landcover studies

    Science.gov (United States)

    Chauhan, H. B.; Dwivedi, R. M.

    2008-06-01

    Coastal zone assumes importance due to high productivity of ecosystems, man-made developmental activities, natural hazards and dynamic nature of the coast. As costal ecosystems are unique and fragile, understanding the impact of developmental activities on the sustainability of the coastal zone is very important. Remote sensing, because of repetitive and synoptic nature is an ideal tool for studying this. Time series data analyses for monitoring coastal zone require different type of sensors. Present study deals with atmospheric correction of satellite data, reflectance, selection of coastal features like, mudflat, mangroves, vegetated dune, coastal water, etc. and their inter-comparison using different sensor data of RESOURCESAT sensors. Reflectance values give better separateability for various coastal features in comparison to DN values. LISS IV can be used in place of LISS III or merged (LISS III + PAN) for long-term coastal zone studies.

  13. Estimation of LISS(local input-to-state stability) properties for nonlinear systems

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Compared with input-to-state stability(ISS) in global version,the concept of local input-to-state stability(LISS) is more relevant and meaningful in practice.The key of assessing LISS properties lies in investigating three main ingredients,the local region of initial states,the local region of external inputs and the asymptotic gain.It is the objective of this paper to propose a numerical algorithm for estimating LISS properties on the theoretical foundation of quadratic form LISS-Lyapunov function.Given developments of linear matrix inequality(LMI) methods,this algorithm is effective and powerful.A typical power electronics based system with common DC bus is served as a demonstration for quantitative results.

  14. Automated Registration of Images from Multiple Bands of Resourcesat-2 Liss-4 camera

    OpenAIRE

    2014-01-01

    Continuous and automated co-registration and geo-tagging of images from multiple bands of Liss-4 camera is one of the interesting challenges of Resourcesat-2 data processing. Three arrays of the Liss-4 camera are physically separated in the focal plane in alongtrack direction. Thus, same line on the ground will be imaged by extreme bands with a time interval of as much as 2.1 seconds. During this time, the satellite would have covered a distance of about 14 km on the ground and the e...

  15. Topographic data bases in the product generation of IRS_P6 Liss-4 imagery

    Science.gov (United States)

    Jyothi, M. V.; Radhadevi, P. V.; Solanki, S. S.

    A continuous and autonomous co-registration and geo-location of image data from multiple sensors with widely varying view angles and resolution is one of the unique challenges of IRS-P6 data processing. The Liss-4 camera is capable of imaging in either multi-spectral or panchromatic modes with steerability up to +/- 27°. As the satellite sweeps longer strips with oblique viewing configuration, data product generation requires an elevation database to accommodate the errors due to terrain topography. SRTM, GTOPO30, DCW etc. are becoming hidden information to product generation schemes. In this paper, we analyze and justify the requirement of inclusion of a global DEM in the product generation system for Liss-4 data. In the first part of the study, after a brief introduction of sensor model, comparison of elevation from SRTM and GTOPO30 is made which leads towards a conclusion that GTOPO30 is adequate for improving the accuracy. The second part deals with the impact of GTOPO30 on geometric accuracy. Thirdly we analyze the terrain effects on band-to-band registration of Liss-4 multispectral data. A perfect band-to-band registration cannot be achieved without inclusion of digital elevation model. Many Liss_4 data sets with different tilts that cover terrain patches with flat, rolling and highly undulating nature are studied and the results reported.

  16. Comparison of FLAASH and QUAC atmospheric correction methods for Resourcesat-2 LISS-IV data

    Science.gov (United States)

    Saini, V.; Tiwari, R. K.; Gupta, R. P.

    2016-05-01

    The LISS-IV sensor aboard Resourcesat-2 is a modern relatively high resolution multispectral sensor having immense potential for generation of good quality land use land cover maps. It generates data in high (10-bit) radiometric resolution and 5.8 m spatial resolution and has three bands in the visible-near infrared region. This is of particular importance to global community as the data are provided at highly competitive prices. However, no literature describing the atmospheric correction of Resourcesat-2-LISS-IV data could be found. Further, without atmospheric correction full radiometric potential of any remote sensing data remains underutilized. The FLAASH and QUAC module of ENVI software are highly used by researchers for atmospheric correction of popular remote sensing data such as Landsat, SPOT, IKONOS, LISS-I, III etc. This article outlines a methodology for atmospheric correction of Resourcesat-2-LISS-IV data. Also, a comparison of reflectance from different atmospheric correction modules (FLAASH and QUAC) with TOA and standard data has been made to determine the best suitable method for reflectance estimation for this sensor.

  17. Evaluation isocinétique de la fatigabilité musculaire du genou: qu'en est-il de la reproductibilité intra-dynamomètre et de la compatibilité inter-dynamomètre?

    OpenAIRE

    Paulus, Julien; Krecke, Roland; Bosquet, Laurent; Gremeaux, Vincent; Crielaard, Jean-Michel; Croisier, Jean-Louis

    2015-01-01

    Abstract Certains aspects de l'isocinétisme, bien que considéré comme un gold standard de l'évaluation musculaire [1], restent à explorer: entre autre la reproductibilité intra-dynamomètre des index de fatigue (quotient des n dernières répétitions par les x premières par exemple) et des paramètres mesurés lors d'une épreuve de fatigabilité musculaire pour le genou mais également la compatibilité inter-dynamomètre de cette même épreuve de résistance à la fatigue. Après étude via à un test-r...

  18. Harmonie et divergences des couples sur les repercussions familiales et sociales apres la survenue d’un accident vasculaire cerebral.

    OpenAIRE

    Baumann, Michèle; Bucki, Barbara

    2012-01-01

    Deux ans après la survenue d’un accident vasculaire cérébral (AVC), l’harmonie et la divergence entre les déclarations des patients et des conjoints ont été analysées auprès de 51 couples vivant au Luxembourg à l’aide d’un entretien mené à leur domicile. « L’AVC a créé des bouleversements considérables dans ma famille » et « au début, personne ne savait quelle attitude avoir avec la personne AVC »; ces retentissements sont, pour les couples, indiscutables. D’autres effets les a...

  19. Development and design of a line imaging spectrometer sampler (LISS) - A user manual

    DEFF Research Database (Denmark)

    Jørgensen, R.N.; Rasmussen, P.

    2002-01-01

    The objective of this report is to develop and describe the software for a Line Imaging Spectrometer Sampler (LISS) to perform measurements of spectra combined with a digital RGB photo of a measurant. Secondly this report should enable users to performmeasurements with the system. The measuring...... are developed as a Graphical User Interfaced (GUI) hosted by Matlab Release 12 from Mathworks. This GUI enables the operator to perform measurements from alldevices simultaneously together with notes specific for the measurant and store all the data in one Matlab data structure. The software includes dynamic...... devices consist of 2 16-bit cooled SBIG ST-6 CCD cameras each equipped with an Imspector imaging spectrograph for measuring reflectance in the visual and the near infrared range, respectively, a digital cameraand a differential global positioning device (dGPS). The controlling and data collecting tasks...

  20. Biomechanics of distal femoral fracture fixed with an angular stable LISS plate.

    Science.gov (United States)

    Pakuła, Grzegorz; Słowiński, Jakub; Scigała, Krzysztof

    2013-01-01

    Fractures of the distal end of the femur are infrequent and constitute less than 1% of all fractures. Only 3% to 6% of femoral fractures occur at the distal end. The two groups most at risk of the said fractures are young men and older women. The aim of treatment of fractures of the distal femur is to restore normal function of the knee joint. The authors asked themselves whether, following fixation of a 33-C2 fracture (according to the AO classification) with a LISS plate, a rehabilitation program can be undertaken immediately after surgery with the implementation of active movements in the knee joint of the operated limb. In order to answer this question, we created a digital model of a fractured femur fixed with the LISS method. The model was subjected to loads corresponding to the loads generated during active lifting of a limb extended in the knee joint and during flexing of a limb in the knee joint to the 90° angle. Interfragmentary movement (IFM) is one of the key parameters taken into account in the treatment of bone fractures. It allows classification of the treatment in terms of its quality both from the mechanical and histological points of view. We analyzed interfragmentary movement in all fracture gaps. The largest recorded displacement reached in our model was 243 μm, which, in the light of the literature data, should not interfere with bone consolidation, and thus implementation of active movement in the operated knee joint (keeping in mind the simplifications of the experimental method used) is possible in the early postoperative period.

  1. Accident vasculaire cérébral ischémique révélant une maladie coeliaque

    OpenAIRE

    2010-01-01

    La maladie cœliaque (MC) de l’adulte est une pathologie fréquente dont la présentation clinique est polymorphe. Les manifestations extradigestives sont multiples et rendent le diagnostic difficile lorsqu’elles sont isolées. Nous rapportons le cas d’un patient de 52 ans qui présentait un accident vasculaire cérébral ischémique (AVCI). Le bilan étiologique objectivait une hyperhomocystéinémie avec une carence en vitamine B12. La biopsie duodénale était en faveur d’une maladie coeliaque. Les ant...

  2. ESTUDO COMPARATIVO ENTRE OS ÍNDICES NDVI OBTIDOS A PARTIR DOS SENSORES LANDSAT 5 - TM E RESOURCESAT - LISS III

    Directory of Open Access Journals (Sweden)

    Cesar Vinícius Mendes Nery

    2013-07-01

    Full Text Available A importância das imagens de sensoriamento remoto para o monitoramento da cobertura vegetal é algo inegável. Por mais de três décadas a série Landsat tem fornecido imagens da terra, porém a partir de novembro de 2011 o satélite interrompeu a disponibilização de suas imagens para o monitoramento ambiental. Uma das alternativas de imagens ao Landsat têm sido as imagens do sensor LISS III a bordo do satélite indiano Resourcesat 1. O presente trabalho tem como área de estudo o município de Janaúba, por estar em uma área de transição de dois biomas, e o mesmo tem por objetivo comparar os dois sensores, o sensor TM que se encontra a bordo do satélite Landsat 5 e o sensor LISS III a bordo do satélite Resourcesat 1. Para esse estudo comparativo as imagens foram adquiridas do site do Instituto Nacional de Pesquisas Espaciais (INPE e seus valores de níveis digitais (ND foram convertidos em reflectância com correção atmosférica utilizando o método de correção DOS. Amostras de pixels das imagens índice foram coletadas para o estudo de correlação e ajuste de uma equação linear por meio da técnica de regressão. Utilizando a equação ajustada foram gerados dois mapas temáticos de ambos os sensores, sendo os mesmos comparados pelo teste estatístico Kappa. Os resultados mostraram uma forte correlação entre os valores de NDVI (0,81, sendo possível o ajuste de uma equação linear que expresse a forma dessa relação. O sensor TM, superestimou os valores de NDVI em relação ao sensor LISS III (Inclinação de 1,1035. O valor de Kappa para os mapas temáticos obtidos foi de 0,5894 e o índice de acerto foi de 98,81%, o que mostra uma boa similaridade entre eles. O sensor LISS III pode ser perfeitamente utilizado como alternativa ao Landsat 5.

  3. Prévalence des calcifications vasculaires et facteurs associés chez le patient hémodialysé

    OpenAIRE

    XHIGNESSE, Patricia; Saint-Remy, Annie; Weekers, Laurent; Dubois, Bernard; Krzesinski, Jean-Marie

    2005-01-01

    Les maladies cardiovasculaires constituent la première cause de décès chez les patients dialysés chroniques. Parmi les facteurs impliqués on trouve les anomalies du métabolisme phosphocalcique. Le but de cette étude est de relier l'incidence de nouvelles calcifications et des décès (22%, n=18) avec les paramètres du métabolisme phosphocalcique au travers d'une étude prospective portant sur les années 2003-2004. L'établissement d'un score de calcification vasculaire précoce (dès la prise en...

  4. Accident vasculaire cérébral ischémique révélant une maladie coeliaque

    Directory of Open Access Journals (Sweden)

    Belfkih Rachid

    2010-04-01

    Full Text Available La maladie cœliaque (MC de l’adulte est une pathologie fréquente dont la présentation clinique est polymorphe. Les manifestations extradigestives sont multiples et rendent le diagnostic difficile lorsqu’elles sont isolées. Nous rapportons le cas d’un patient de 52 ans qui présentait un accident vasculaire cérébral ischémique (AVCI. Le bilan étiologique objectivait une hyperhomocystéinémie avec une carence en vitamine B12. La biopsie duodénale était en faveur d’une maladie coeliaque. Les anticorps antigliadines étaient positifs. Le patient fût mis sous régime sans gluten, anti-aggrégant plaquettaire et hydroxocobalamine avec une évolution favorable.

  5. Evaluation médico-économique de la thrombolyse de l'accident vasculaire cérébral hyperaigu par le rtPA (Actilyse)

    OpenAIRE

    2003-01-01

    L'AVC (accident vasculaire cérébral) représente la troisième cause de mortalité et la première cause de handicap fonctionnel chronique dans la population adulte occidentale. Son fardeau économique compte parmi les plus élevés de toutes les maladies. Ce mémoire a pour objet d'étudier l'impact économique d'une nouvelle procédure d'intervention, la thrombolyse des infarctus cérébraux par le rtPA, sur les coûts du Centre hospitalier universitaire vaudois. [Table des matières] 1. Introduction. 2. ...

  6. Stochastic gradient boosting classification trees for forest fuel types mapping through airborne laser scanning and IRS LISS-III imagery

    Science.gov (United States)

    Chirici, G.; Scotti, R.; Montaghi, A.; Barbati, A.; Cartisano, R.; Lopez, G.; Marchetti, M.; McRoberts, R. E.; Olsson, H.; Corona, P.

    2013-12-01

    This paper presents an application of Airborne Laser Scanning (ALS) data in conjunction with an IRS LISS-III image for mapping forest fuel types. For two study areas of 165 km2 and 487 km2 in Sicily (Italy), 16,761 plots of size 30-m × 30-m were distributed using a tessellation-based stratified sampling scheme. ALS metrics and spectral signatures from IRS extracted for each plot were used as predictors to classify forest fuel types observed and identified by photointerpretation and fieldwork. Following use of traditional parametric methods that produced unsatisfactory results, three non-parametric classification approaches were tested: (i) classification and regression tree (CART), (ii) the CART bagging method called Random Forests, and (iii) the CART bagging/boosting stochastic gradient boosting (SGB) approach. This contribution summarizes previous experiences using ALS data for estimating forest variables useful for fire management in general and for fuel type mapping, in particular. It summarizes characteristics of classification and regression trees, presents the pre-processing operation, the classification algorithms, and the achieved results. The results demonstrated superiority of the SGB method with overall accuracy of 84%. The most relevant ALS metric was canopy cover, defined as the percent of non-ground returns. Other relevant metrics included the spectral information from IRS and several other ALS metrics such as percentiles of the height distribution, the mean height of all returns, and the number of returns.

  7. Monitoring Environment with GIS for Part of Thiruvallur Town Using Cartosat 1 Stereo, Pan & Resourcesat Liss 4 MSS Merged Data

    Science.gov (United States)

    Mohamed, G. S.; Venkatchalam, R. V.; Ramamurthhy, M.; Gummidipoondi, R. J.; Ramillah, M.

    2012-07-01

    Thiruvallur town is about 44 km from Chennai in Tamil nadu state of India with a population of 130000 , covering 10.75 sq km area. It is about 2km from Sri Venkateswara College of Engineering and Technology. It was Taluk (Sub Division'.s) head quarters and from 1991 it was upgraded as District head quarters after the formation of Thiruvallur District. With rapid growth of town the Population density of Thiruvallur has increased in the past three decades from 300 persons/sq.km in 1951, to 6000 persons/sq.km in 1981 and now it is 12925 persons/sq.km in 2011. The creation of District administrative collector office, headquarters offices for police, judicial courts and Tamil Nadu and Federal Government development department's offices, establishment of multinationals major industries like Caterpillar, Kingfishers,Hindustan Motors, Mahendra Automobiles, Coco cola, Japanese Glass industry, Korean LOTO etc apart from mushrooming growth of about 41 Engineering, Nursing, Education, Medical, Naval, Arts and Science colleges, International Public schools,Governmentt, Private schools and Polytechnics added to the population of this Town. It is well connected by National Highways and Railways and upgraded as District Municipality. This resulted in urban drainage problem and conversion of Agriculture land and lakes for housing, establishment of major Govt and Private Hospitals including special units for Eye care, Cardiology, and Health Clinics, pharmacies etc. The effect of urbanization on environment of this once silent rural temple town which was supporting intensive agriculture activities , green with paddy fields is studied with high resolution satellite data is know the impact on health and environment changes from 2008 to 2011, using 2.5m resolution PAN stereo data of Cartosat 1 merged with 5.8 m resolution Multi Spectral data of LISS 4 of Resourcesat 1 of Indian Remote sensing satellites and Geo Eye satellite image of 2011 from Google Earth web site for the western part

  8. La programmmation foetale de la dysfonction vasculaire pulmonaire chez la souris : rôle des mécanismes épigénétiques = Fetal programming of pulmonary vascular dysfunction in mice : role of epigenetic mechanisms

    OpenAIRE

    Rexhaj, E.

    2011-01-01

    Rapport de synthèseDes événements pathologiques survenant pendant la période foetale prédisposent la descendance aux maladies cardiovasculaires systémiques. Il existe peu de connaissances au sujet de la circulation pulmonaire et encore moins quant aux mécanismes sous-jacents. La sous-alimentation maternelle pendant la grossesse peut représenter un modèle d'investigation de ces mécanismes, parce que chez l'animal et l'homme elle est associée à une dysfonction vasculaire systémique chez la prog...

  9. Incidence des accidents vasculaires cérébraux chez les patients VIH positifs sous traitement antirétroviral au long court

    Science.gov (United States)

    Mapoure, Yacouba Njankouo; Nkongni, Ines Nepetsoun; Luma, Henry Namme; Ngahane, Bertrand Hugo Mbtachou; Barla, Esther; Ngwane, Samuel; Mouelle, Albert Soné; Njamnshi, Alfred Kongnyu

    2016-01-01

    Introduction Avec l'introduction de la trithérapie dans les années 1996, la morbidité et la mortalité liées à l'infection par le VIH a nettement diminué. Concomitamment avec ce succès clinique, plusieurs changements métaboliques incluant diabète, hypertension artérielle, dyslipidémie et lipodystrophie ont été observés, ceux-ci étant des pourvoyeurs d'accidents vasculaires cérébraux. L'objectif de ce travail était de déterminer l'incidence des accidents vasculaires cérébraux chez les patients VIH positifs sous traitement antirétroviral au long court. Méthodes Il s'agissait d'une étude de cohorte rétrospective, menée dans le Centre de Traitement Agrée de l'Hôpital Général de Douala (HGD), avec un recueil des données sur 10 ans allant de Mai 2001 à avril 2010, portant sur les patients VIH positifs adultes sous traitement antirétroviral depuis au moins 6 mois. Les patients étaient suivis selon le protocole national de prise en charge du Cameroun. La survenue d'un AVC a été déterminée par la méthode Kaplan-Meyer tandis que les facteurs associés à la survenue d'un AVC ont été recherché par le test de Khi-2. Le seuil de signification statistique était fixé à 0,05. Résultats 307 patients étaient inclus dont 62,4% de sexe féminin, et l’âge moyen était de 40,1 ± 9,9 ans. L'incidence des AVC était de 1,7% sur 72 mois de suivi sans différence significative entre les femmes et les hommes (P= 0,76). Le taux d'incidence calculé était de 0,3 pour 100 personnes années. Dans 85,7% des cas il s'agissait d'un AVC ischémique. Le délai moyen de survenue d'un AVC était de 33,4 mois. Les facteurs associés à la survenue d'un AVC étaient: les patients ayant initié leur traitement au stade III et IV de l'OMS et le taux de CD4 > 100/mm3 à l'initiation du traitement antirétroviral. Conclusion L'incidence des AVC chez les patients VIH positifs sous traitement antirétroviral est similaire à celle rapportée ant

  10. Etude du point critique des paliers lisses alimentés à la graisse Study of Critical Point on Plain Bearings Lubricated by Grease

    Directory of Open Access Journals (Sweden)

    Delneuville P.

    2006-11-01

    Full Text Available Cet article est essentiellement consacré à l'étude du fonctionnement limite des paliers lisses lubrifiés à la graisse ; son but est de permettre la détermination des conditions nécessaires à l'obtention d'un film lubrifiant d'épaisseur suffisante. L'auteur cherche à cette occasion une loi théorique qui permet de départager les régimes de lubrification, non plus empiriquement, mais sur la base de lois statistiques. La formulation finale doit permettre aux utilisateurs de situer correctement les conditions de fonctionnement d'un palier lisse et d'en estimer la sécurité du régime. This article deals essentially with the boundary behaviour of plain bearings lubricated by grease. Its aim is to determine the conditions required to obtain a sufficiently thick lubricating film. The author proposes a theoretical law for separating lubrication types. This law is not empirical but is based on statistical laws. The final formulation should enable users to correctly situate the operating conditions of a plain bearing and to evaluate the safety factor during running.

  11. Extracting seasonal cropping patterns using multi-temporal vegetation indices from IRS LISS-III data in Muzaffarpur District of Bihar, India

    Directory of Open Access Journals (Sweden)

    Saptarshi Mondal

    2014-12-01

    Full Text Available The advancement in satellite technology in terms of spatial, temporal, spectral and radiometric resolutions leads, successfully, to more specific and intensified research on agriculture. Automatic assessment of spatio-temporal cropping pattern and extent at multi-scale (community level, regional level and global level has been a challenge to researchers. This study aims to develop a semi-automated approach using Indian Remote Sensing (IRS satellite data and associated vegetation indices to extract annual cropping pattern in Muzaffarpur district of Bihar, India at a fine scale (1:50,000. Three vegetation indices (VIs – NDVI, EVI2 and NDSBVI, were calculated using three seasonal (Kharif, Rabi and Zaid IRS Resourcesat 2 LISS-III images. Threshold reference values for vegetation and non-vegetation thematic classes were extracted based on 40 training samples over each of the seasonal VI. Using these estimated value range a decision tree was established to classify three seasonal VI stack images which reveals seven different cropping patterns and plantation. In addition, a digitised reference map was also generated from multi-seasonal LISS-III images to check the accuracy of the semi-automatically extracted VI based classified image. The overall accuracies of 86.08%, 83.1% and 83.3% were achieved between reference map and NDVI, EVI2 and NDSBVI, respectively. Plantation was successfully identified in all cases with 96% (NDVI, 95% (EVI2 and 91% (NDSBVI accuracy.

  12. L'obésité en consultation cardiologique à Lomé: prévalence et facteurs de risque cardio-vasculaire associés - étude chez 1200 patients

    Science.gov (United States)

    Pessinaba, Soulemane; Yayehd, Komlavi; Pio, Machiude; Baragou, Réné; Afassinou, Yaovi; Tchérou, Tchaa; Damorou, Findibé

    2012-01-01

    Introduction Introduction: Les objectifs de ce travail étaient de déterminer la fréquence de l'obésité et celle des autres facteurs de risque cardio-vasculaire chez ces patients obèses à Lomé (Togo). Méthodes Il s'est agi d'une étude multicentrique transversale de prévalence. Elle s'est déroulée du 05 septembre 2005 au 04 mars 2006 et a porté sur les malades vus en consultation externe dans 3 services de cardiologie de la commune de Lomé. Ont été inclus dans cette étude les malades ayant un surpoids selon les normes de l'OMS. Résultats Parmi 1200 patients vus en consultations, 779 (64,92%) avaient une surcharge pondérale. L’âge moyen était de 49,53 ± 17,24 ans. L'obésité était plus fréquente chez les femmes (79,49%) que chez les hommes (20,51%). Un antécédent d'obésité familiale (61,8%) était le principal facteur favorisant. Les autres facteurs de risque cardio-vasculaire retrouvés étaient: sédentarité (82% vs50% chez les non obèses), hypertension artérielle (54,8% vs 39,2%), alcool (50,9% vs 43,9%), dyslipidémie (34,5% vs 20%), diabète (30,9% vs 10,7%) et tabac (14,1% vs 20,3%). La différence était statistiquement significative entre les deux groupes. Les principales complications cardiovasculaires observées chez les obèses étaient: l'ischémie myocardique (26,7%), l'hypertrophie ventriculaire gauche (46,4%), la dilatation cavitaire cardiaque (30,1%) et les accidents vasculaires cérébraux (7,1%). Conclusion L'obésité est un problème de santé publique au Togo. Sa prévalence est très élevée et elle est le plus souvent associée aux autres facteurs de risque cardio-vasculaire. Des mesures préventives doivent être mises en jeu pour lutter contre ce facteur de risque. Mots clés: Obésité, prévalence, facteurs de risque. PMID:23133699

  13. Corrélations entre maillages 3D au moyen du logiciel R : application à l'imagerie par IRM de l'accident vasculaire cérébral

    OpenAIRE

    2013-01-01

    International audience; Nous présentons une analyse statistique, réalisée avec le logiciel R, sur des images obtenues par imagerie par résonance magnétique (IRM) dans le cadre d'un suivi longitudinal de patients ayant subi un accident vasculaire cérébral (AVC). L'analyse s'effectue sur une cohorte d'environ 400 patients suivis à 4 dates différentes : heure d'arrivée aux urgences, deux heures après, deux jours après puis un mois après. Les patients de cette cohorte sont tous atteints d'un AVC,...

  14. Estimation and Mapping Forest Attributes Using “k Nearest Neighbor” Method on IRS-P6 LISS III Satellite Image Data

    Directory of Open Access Journals (Sweden)

    Amir Eslam Bonyad

    2015-06-01

    Full Text Available In this study, we explored the utility of k Nearest Neighbor (kNN algorithm to integrate IRS-P6 LISS III satellite imagery data and ground inventory data for application in forest attributes (DBH, trees height, volume, basal area, density and forest cover type estimation and mapping. The ground inventory data was based on a systematic-random sampling grid and the numbers of sampling plots were 408 circular plots in a plantation in Guilan province, north of Iran. We concluded that kNN method was useful tool for mapping at a fine accuracy between 80% and 93.94%. Values of k between 5 and 8 seemed appropriate. The best distance metrics were found Euclidean, Fuzzy and Mahalanobis. Results showed that kNN was accurate enough for practical applicability for mapping forest areas.

  15. Profil clinique de la dépression post- accident vasculaire cérébral étude transversale descriptive menée au centre de réhabilitation des personnes handicapées de Kinshasa (RD Congo)

    OpenAIRE

    2014-01-01

    Introduction: L'objectif général poursuivi dans cette étude est de décrire le tableau clinique de la dépression post-accident vasculaire cérébral (DPAVC) à Kinshasa. Méthodes: Il s'agit d'une étude transversale descriptive portant sur 56 patients suivis pour hémiplégie post-accident vasculaire cérébral au Centre de réhabilitation pour personnes handicapées de Kinshasa (CRPHK) du 1er au 31 août 2011. Résultats: Au Patient Health Questionnaire (PHQ9), 21. 40 % des patients présentaient une dépr...

  16. ASPECTS NUTRITIONNELS DES ACIDES GRAS TRANS : Consommation en acides gras trans et risque cardio-vasculaire : Étude Aquitaine

    Directory of Open Access Journals (Sweden)

    Combe Nicole

    2000-01-01

    Full Text Available Au cours de cette dernière décennie, les études sur la consommation d’acides gras trans (AGT se sont multipliées pour en préciser l’impact éventuel sur le risque de maladies cardio-vasculaires (MCV. À l’origine, se trouve l’étude américaine de Willett et al. [1], conduite sur une cohorte de 85 000 infirmières suivies pendant 8 ans. Cette étude épidémiologique rapportait l’existence d’une corrélation positive entre la consommation d’AGT d’origine végétale et l’apparition de MCV. Ont suivi d’autres études que l’on peut classer en trois catégories selon leur approche expérimentale : les études épidémiologiques [2-5] longitudinales ou transversales, les comparaisons « cas-témoins » [6-11] et les interventions nutritionnelles [12-15]. Des deux premières catégories d’études, il n’émerge aucun consensus quant à l’implication éventuelle des AGT alimentaires dans le risque de MCV. Les divergences observées pourraient, en partie tout au moins, être liées à la méthode utilisée pour estimer la consommation d’AGT qui, dans certains cas, est fondée sur des enquêtes alimentaires et, dans d’autres cas, sur la teneur en AGT du tissu adipeux des sujets, connue pour refléter l’apport alimentaire en AGT des années précédentes. En effet, au-delà de considérations sur de possibles biais méthodologiques [16], comme le non-ajustement des résultats à des facteurs de confusion tels que l’âge, la consommation de tabac ou certaines pathologies, on peut faire le constat suivant : les études qui ont conclu à un effet négatif des AGT alimentaires étaient fondées, pour la plupart, exclusivement sur des enquêtes alimentaires [1-3, 11] ; celles qui ne montraient aucun effet utilisaient, le plus souvent, la composition en AGT du tissu adipeux [4, 6-9]. La carence, dans les bases de données, vis-à-vis des teneurs en AGT des aliments augmente, en outre, la difficulté à déterminer la

  17. Investigating the Capability of IRS-P6-LISS IV Satellite Image for Pistachio Forests Density Mapping (case Study: Northeast of Iran)

    Science.gov (United States)

    Hoseini, F.; Darvishsefat, A. A.; Zargham, N.

    2012-07-01

    In order to investigate the capability of satellite images for Pistachio forests density mapping, IRS-P6-LISS IV data were analyzed in an area of 500 ha in Iran. After geometric correction, suitable training areas were determined based on fieldwork. Suitable spectral transformations like NDVI, PVI and PCA were performed. A ground truth map included of 34 plots (each plot 1 ha) were prepared. Hard and soft supervised classifications were performed with 5 density classes (0-5%, 5-10%, 10-15%, 15-20% and > 20%). Because of low separability of classes, some classes were merged and classifications were repeated with 3 classes. Finally, the highest overall accuracy and kappa coefficient of 70% and 0.44, respectively, were obtained with three classes (0-5%, 5-20%, and > 20%) by fuzzy classifier. Considering the low kappa value obtained, it could be concluded that the result of the classification was not desirable. Therefore, this approach is not appropriate for operational mapping of these valuable Pistachio forests.

  18. Evaluation of Catrosat 1PAN Stereo and Resourcesat Liss 4 MSS Merged Data for Morphometric Analysis, Delineation of Drainage Basins and Codification in Tamil Nadu, India and Australia

    Science.gov (United States)

    Mohamed, G. S.; Srinivasan, S.; Pandian, R.; Gummidipoondi, R. J.; Venkatchalam, R. V.; Swaminathan. S, S.

    2012-07-01

    The Topographic maps and Aerial Photographs are used for morphometric analysis of drainage basins and mapping contours with drainage. The stereo pairs of 2.5 m resolution Cartosat 1, Indian satellite 2 and merged data with 5.5 m resolution P6 Resourcesat 1 LISS 4 Indian satellite of 2001 is used to map, rills, gullies, and streams of first order to evaluate part of drainage basin of Cooum and Poondi Reservoir in Thiruvallur taluk of Tamil Nadu state. The Geo Eye latest 2011data is also used with Catrosat 1Stereo data to study present morphology of tiny micro watersheds to study the use of High resolution data for delineation and codification of watersheds. This study area is in an inter fluvial drainage basin of Cooum and Kusasthalai rivers. Kusasthalai river drains in Poondi reservoir which is about 50 km from Chennai. The excess water from Kosasthalai is also diverted through Kesawaram weir to Cooum river which passes through Thiruvallur and Chennai city before it's confluence with Bay of Benegal in the east. As Cooum basin is at higher elevation, water for irrigation is again diverted through chain of tanks to Kusasthalai river basin to drain in Poondi reservoir. Delineation of water sheds in this fluvial basin is difficult by manual survey as man made irrigation channels, natural drainage streams etc., have to be clearly identified. The streams of various orders are identified based on Strahler stream order hierarchy of tributaries, slops and contours using large scale satellite data. The micro water sheds are delinated identifying the ridges from Catrosat data for this interfluves basin which has mild slop. To illustrate this research, parts of two micro watersheds which were delineated using 1:50000 data for Tamil Nadu watershed Atlas up to 7th order streams are taken up for a detailed study using high resolution data. 19 Micro watersheds with streams up to 10th order are mapped. The capability of high resolution satellite data for digital as well as visual

  19. EVALUATION OF CATROSAT 1PAN STEREO AND RESOURCESAT LISS 4 MSS MERGED DATA FOR MORPHOMETRIC ANALYSIS, DELINEATION OF DRAINAGE BASINS AND CODIFICATION IN TAMIL NADU, INDIA AND AUSTRALIA

    Directory of Open Access Journals (Sweden)

    G. S. Mohamed

    2012-07-01

    Full Text Available The Topographic maps and Aerial Photographs are used for morphometric analysis of drainage basins and mapping contours with drainage. The stereo pairs of 2.5 m resolution Cartosat 1, Indian satellite 2 and merged data with 5.5 m resolution P6 Resourcesat 1 LISS 4 Indian satellite of 2001 is used to map, rills, gullies, and streams of first order to evaluate part of drainage basin of Cooum and Poondi Reservoir in Thiruvallur taluk of Tamil Nadu state. The Geo Eye latest 2011data is also used with Catrosat 1Stereo data to study present morphology of tiny micro watersheds to study the use of High resolution data for delineation and codification of watersheds. This study area is in an inter fluvial drainage basin of Cooum and Kusasthalai rivers. Kusasthalai river drains in Poondi reservoir which is about 50 km from Chennai. The excess water from Kosasthalai is also diverted through Kesawaram weir to Cooum river which passes through Thiruvallur and Chennai city before it's confluence with Bay of Benegal in the east. As Cooum basin is at higher elevation, water for irrigation is again diverted through chain of tanks to Kusasthalai river basin to drain in Poondi reservoir. Delineation of water sheds in this fluvial basin is difficult by manual survey as man made irrigation channels, natural drainage streams etc., have to be clearly identified. The streams of various orders are identified based on Strahler stream order hierarchy of tributaries, slops and contours using large scale satellite data. The micro water sheds are delinated identifying the ridges from Catrosat data for this interfluves basin which has mild slop. To illustrate this research, parts of two micro watersheds which were delineated using 1:50000 data for Tamil Nadu watershed Atlas up to 7th order streams are taken up for a detailed study using high resolution data. 19 Micro watersheds with streams up to 10th order are mapped. The capability of high resolution satellite data for digital

  20. Rule-based semi-automated approach for the detection of landslides induced by 18 September 2011 Sikkim, Himalaya, earthquake using IRS LISS3 satellite images

    Directory of Open Access Journals (Sweden)

    Sajad Siyahghalati

    2016-01-01

    Full Text Available Landslide is considered as one of the most devastating and most costly natural hazards in highlands, which is triggered mainly by rainfalls or earthquakes. In comparison with other methods, landslide mapping and monitoring via remote sensing data products are considered as the least expensive method of data collection. The current research attempts to detect landslides which occurred due to a 6.9 magnitude earthquake in Sikkim Himalaya, India, on 18 September 2011 and also to establish the spatial relationship between landslides and the slope of the terrain. To detect the landslides, decision tree method was applied on two Indian remote sensing satellites linear imaging self-scanning sensor (LISS III images acquired from 2007 and 2011 which were taken before and after the earthquake. As the study area was relatively huge for identifying the landslides, the region was separated into two parts: “tested study area” and “real study area”. The overall accuracy of landslide detection was 76%, and 75% for tested and real study area, respectively. Then, the spatial relationship between the landslides and the slope of the terrain was conducted using the digital elevation model. The results revealed that most of the landslides occurred between the slope of 25° and 45° covering 2.3 km2 and no landslide recorded in the slope of 65°–90° in the real study area. The results obtained in this study may be useful for decision-making and policy support towards reconstruction effort after the landslide occurrence. In addition, the information can be useful for reducing the risk of potential damages to substructures and properties by developing new and efficient strategies.

  1. 微创LISS钢板治疗胫腓骨骨折疗效观察%The observation of the effect of using minimally invasive LISS in the treatment of tibia and fibula fractures

    Institute of Scientific and Technical Information of China (English)

    黄朝靖; 孟山明

    2014-01-01

    目的:分析AO微创内固定系统( LISS)治疗胫腓骨骨折疗效。方法手术治疗92例胫腓骨骨折患者, LISS钢板组47例,解剖钢板组45例,观察两组骨折复位、膝关节功能恢复情况。结果患者均获随访,时间6~24个月。两组骨折愈合时间、内翻角比较差异无统计学意义( P>0.05);LISS钢板组后倾角、膝关节自由活动度分别为10.7°±2.9°、128.3°±18.5°,均大于解剖钢板组的8.3°±1.7°、102.4°±17.6°(P0. 05). The dip, knee free activity of the LISS plate group was 10. 7° ± 2. 9°,128. 3° ± 18. 5°, which were greater than those in the anatomic plate group of 8. 3° ± 1. 7°, 102. 4° ± 17. 6°(P<0. 01). Knee function score of the LISS plate group was (98. 4 ± 20. 3) points, higher than that in the anatomic plate group of (80. 3 ± 18. 9) points (P<0. 01). Complication rate of the LISS plate group was 4. 26%, lower than that in anatomic plate group of 20. 00% (P<0. 05). Conclusions LISS is safe and reliable in the treatment of tibia and fibula fractures. The knee function recovers well.

  2. Commande vectorielle de la machine a reluctance variable à stator lisse. Prise en compte de la saturation et de l'amortissement

    Science.gov (United States)

    Tounzi, A.; Meibody-Tabar, F.; Sargos, F. M.

    1997-04-01

    This paper deals with the field-oriented control of a smooth stator, non excited salient rotor synchronous machine. First, a nonlinear modelling of the machine, taking into account both damping and saturation effects, is developed in PARK's rotor-bound frame. Then, a vector control strategy, which maintains a constant saturation level in the machine, is set-up. This strategy, wich consists in keeping the stator direct current at a high constant value, allows to linearize the model of the machine and to control it in the same way as a DC machine. A numerical simulation of a VRM, fed by a PWM-VSI and controlled thanks to this control strategy, is built up and the computed results are given and commented. Cet article est consacré à la commande vectorielle d'une machine à réluctance variable à stator lisse et rotor massif. D'abord, une modélisation non linéaire de la machine a été effectuée dans le repère de Park. Cette dernière permet de prendre en compte l'effet d'amortissement dû au rotor massif, ainsi que celui de la saturation inhérent à ce genre de machine. Ensuite, une stratégie de contrôle vectoriel, qui maintient un niveau de saturation constant dans la machine, a été élaborée. Cette stratégie, qui consiste à maintenir le courant direct statorique à une valeur élevée, permet de linéariser le modèle de la machine et ainsi de pouvoir la contrôler comme une machine à courant continu. Une simulation numérique de la machine à réluctance variable, alimentée par un onduleur de tension à MLI et commandée par la stratégie mise au point, a été effectuée. Les résultats de cette simulation sont donnés et commentés à la fin de l'article.

  3. 倒置LISS与弹性钉治疗大龄儿童股骨转子下骨折的比较%Less invasive stabilization system (LISS) versus elastic nailing for children with subtrochanteric femur fractures

    Institute of Scientific and Technical Information of China (English)

    杨杰; 黄高; 田乃锋; 孙辽军; 郭晓山

    2013-01-01

    Objective To compare the complications and clinical outcome of reverse less invasive stabilization system (LISS) and elastic nailing for the treatment of subtrochanteric femur fractures in older children.Methods Fifteen children aged from 9 to 15 years old were admitted in this hospital for the treatment of subtrochanteric fractures.The 15 patients subtrochanteric fractures were fixed with reverse LISS.The other 26 patients,who underwent elastic nail fixation for the treatment of subtrochanteric fractures in the same period,were taken as controls.Operative indications,hip joint function and complications of these 2 groups were retrospectively analyzed.Results The average follow-up period of the patients was 30.5 months in LISS group,and 36.2 months in the elastic nail group.No significant difference between these 2 groups was found in fracture healing time,full weight-bearing time and average hospital stay.However,the patients of the LISS group had longer operation time (60.0 ± 10.6 min vs.40.5 ± 7.4 min,P<0.05),less intraoperative blood loss (130.0 ± 55.0 ml vs.30.5 ± 15.0 ml,P<0.05) and more hospital costs (25 000-± 800 RMB vs.12 000 ± 500 RMB,P<0.05).The postoperative complication of these 2 groups was no statistically different,but the patients of the LISS group had a higher incidence of incisional pain,and the elastic nail group had a higher incidence of misalignment.Average Sanders hip function score of LISS group was not significantly different from that of elastic nail group (58.20 vs.58.77,P>0.05).Conclusions The clinical outcome of LISS is comparable with elastic nailing for the treatment of subtrochanteric femur fractures in older children.The fixation device should be selected according to the associated injury,severity of soft tissue injuries and family economic status.%目的 比较倒置LISS及弹性钉固定大龄儿童股骨转子下骨折的临床疗效及并发症.方法 采用LISS倒置固定15例年龄9~15岁的股骨转子下

  4. aspects tissulaires, vasculaires, cellulaires et biochimiques

    OpenAIRE

    Quéré, Nadine

    2010-01-01

    Dissertação de Mestrado apresentada à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Psicopedagogia Perceptiva. Ce mémoire présente une exploration de certaines recherches scientifiques concernant les fascias afin d’éclairer les impacts cellulaires et biochimiques du geste thérapeutique manuel en fasciathérapie Méthode Danis Bois. Ma recherche s’est effectuée à partir de publications récentes : ouvrages, documents Internet et articles ...

  5. Angiomyolipome rénale: à propos de huit cas

    Science.gov (United States)

    Statoua, Mouad; El Ghanmi, Jihad; Karmouni, Tarik; El Khader, Khalid; Koutani, Abdellatif; Attya, Ahmed Iben

    2014-01-01

    L'angiomyolipome est la tumeur bénigne la plus fréquente des masses dolides du rein, elle représente un cadre de fréquence de 1 à 3% des tumeurs du rein, sa composition histologique est faite de trois contingents: graisseux, fibres musculaires lisses et vasculaires a des proportions variables, elle sévit sur un cadre sporadique et peut s'exprimer dans un cadre congénitale comme manifestation de la sclérose tubéreuse de Bourneville. Nous rapportons l'expérience du service d'Urologie B du CHU IBN Sina de Rabat dans la prise en charge de huit cas d'angiomyolipome sur une période s’étalant sur six ans en précisant les manifestations cliniques, données de l'imagerie, le résultat histologique et la conduite thérapeutique. Les manifestations cliniques ne lui sont pas spécifiques, elle peut se manifester par des lombalgies, crise de colique néphritiques, hématurie, masse palpable dans le flanc. La TDM reste l'examen radiologique le plus sensible en mettant en évidence la présence de graisse au sein de la masse, l'histologie confirme le diagnostic et il n'y a aucun consensus qui régit la prise en charge de ce type de tumeur, on peut admettre une surveillance pour les petites masses de moins de 4 cm et traité les formes symptomatiques ou qui dépasse les 4 cm par embolisation ou chirurgie partielle ou totale. Les nouvelles thérapeutiques focales peuvent révolutionner la prise en charge de ce type de tumeur bénigne, mais les études sont toujours en cours. PMID:25767658

  6. LISS钢板治疗膝关节周围严重粉碎性骨折疗效观察%LISS plate for treatment of severe comminuted fractures around the knee Efficacy

    Institute of Scientific and Technical Information of China (English)

    张越民; 苏文

    2015-01-01

    Objective To investigate the AO Less Invasive Stabilization System (less invasive stabilization system, LISS) treatment of severe comminuted fractures around the knee and the efficacy of surgical indications. Method In March 2009-2012 years, in October applied around the LISS plate for treatment of severe comminuted fracture of the knee in 23 cases, including 13 cases of femoral fractures, tibial fractures in 10 cases. Combined patella fracture in 2 cases, with other parts of the fracture in 4 cases. According to AO/OTA classification, femur fractures , 33-A3 type 3 cases ,33-C2-type 6 cases ,33-C3 type 4 cases;tibial fractures ,41-A3 type 3 cases ,41-B2 type 4 cases, 41-C2-type 3 case. Use of indirect reduction surgery,Chong-dimensional incision, the periosteum and the muscles inserted between the outer steel plate,a small incision through the skin will take locking head screws with locking screw plate. Results All patients were followed up,with an average time of 15 months (12 to 24 months). Wound healed, and 1 case of delayed union of bone. HSS score:excellent in 17 cases, good in 3 cases, 2 case and poor in 1 case, good rate of 86.9%.Conclusion LISS plate for the treatment of severe comminuted around the knee with a minimally invasive,reliable fixation,postoperative recovery was quick and fast fracture healing advantages of the treatment of severe comminuted fractures around the knee the ideal fixation materials. Clear hand Surgery indications , strict control procedures and attention to the treatment of bone defects is the key to satisfactory effect.%目的:探讨AO微创内固定系统(less invasive stabilization system,LISS)治疗膝关节周围严重粉碎性骨折的手术适应证及其疗效。方法2009年3月—2012年10月应用LISS钢板治疗膝关节周围严重粉碎性骨折23例,其中股骨骨折13例,胫骨骨折10例。合并髌骨骨折2例,伴其他部位骨折4例。按AO/OTA分型,股骨骨折中,33-A3型3例,33-C2型6

  7. Uso de imagens do LISS-3/Resourcesat-1 e do OLI/Landsat-8 no estudo espacial da queda do nível de água no lago de Furnas no ano de 2012

    Directory of Open Access Journals (Sweden)

    Gabriel Thomé Brochado

    2014-10-01

    Full Text Available O presente trabalho teve como objetivo analisar, por meio de imagens de diferentes sensores e técnicas de geoprocessamento, o efeito da queda do nível de água que ocorreu no Lago de Furnas no ano de 2012. Esta análise foi feita com base nas imagens satélites em três distintos anos: antes do evento (imagens de 2010, durante o evento (imagens de 2012 e depois do evento (imagens do ano de 2013. Para realizar o mapeamento do nível de água nos anos de 2010 e 2012 foram utilizadas imagens do LISS3/Resourcesat-1 e para o ano de 2013 imagens do OLI/Landsat-8, todas processadas e interpretadas em ambiente SIG. O produto final apresenta quatro classes: i superfície de água permanente nos três anos, ii superfície seca permanente nos três anos, iii superfícies de água recuperada e iv não recuperada até ao último ano (2013. A metodologia consistiu de cinco etapas: preparo, fatiamento, álgebra de mapas, edição matricial e cálculo de áreas. O mapa da redução do nível de água do Lago foi gerado a partir de uma operação matricial algébrica entre as máscaras de superfície de água extraídas das bandas do infravermelho próximo, cujo resultado foi editado manualmente para corrigir erros de classificação. Para validar o mapa foram usadas fotografias veiculadas pela imprensa local, durante o evento de redução de nível de água. Os resultados desta pesquisa permitiram concluir que esta metodologia é fácil de ser reproduzida e pode ser utilizada em outras regiões.

  8. Computer-supported indirect-form lifestyle-modification support program using Lifestyle Intervention Support Software for Diabetes Prevention (LISS-DP) for people with a family history of type 2 diabetes in a medical checkup setting: a randomized controlled trial.

    Science.gov (United States)

    Tokunaga-Nakawatase, Yuri; Nishigaki, Masakazu; Taru, Chiemi; Miyawaki, Ikuko; Nishida, Junko; Kosaka, Shiho; Sanada, Hiromi; Kazuma, Keiko

    2014-10-01

    To investigate the effect of a computer-supported indirect-form lifestyle-modification program using Lifestyle Intervention Support Software for Diabetes Prevention (LISS-DP), as a clinically feasible strategy for primary prevention, on diet and physical activity habits in adults with a family history of type 2 diabetes. This was a two-arm, randomized controlled trial: (1) lifestyle intervention (LI) group (n=70); (2) control (n=71). Healthy adults aged 30-60 years with a history of type 2 diabetes among their first-degree relatives were recruited. LI group received three times of lifestyle intervention using LISS-DP during six-month intervention period via mail. Lifestyle intervention group showed significantly greater decrease in energy intake six months after baseline, compared to control (-118.31 and -24.79 kcal/day, respectively, p=0.0099, Cohen's d=0.22), though the difference disappeared 1 year after from baseline. No difference was found in physical activity energy expenditure. A computer-based, non-face-to-face lifestyle intervention was effective on dietary habits, only during the intervention period. Further examination of the long-term effects of such intervention and physical activity is required. Copyright © 2014 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

  9. THERAPIE CELLULAIRE POUR L'ACCIDENT VASCULAIRE CEREBRAL

    OpenAIRE

    Detante, Olivier

    2013-01-01

    Stroke is the leading cause of disability for adults. Excepted hospitalization in specialized Stroke Unit, the only treatment for ischemic stroke is thrombolysis which has to be done only during the first hours after the stroke onset. Enhance post-stroke cerebral plasticity is a major therapeutic aim. For this purpose, cell therapy, based on stem cell injection (or graft) and neural repair, leads to functional benefit in experimental models of cerebral ischemia. However, several issues remain...

  10. Analysis of 50 cases of arthroscopic minimal invasion combined with LISS steel plate in treatment of knee joint injuries%关节镜下微创加LISS钢板治疗膝关节损伤50例分析

    Institute of Scientific and Technical Information of China (English)

    石玉刚; 沙广钊; 朱献忠; 沙磊

    2015-01-01

    目的:探讨关节镜下微创加LISS钢板治疗膝关节损伤的疗效。方法2010年1月~2014年7月我科收治膝关节损伤患者100例。分观察组和对照组各50例,观察组采用关节镜下微创加LISS钢板治疗;对照组采用开放复位钢板螺丝钉固定骨折,直视下修复交叉韧带和侧副韧带,修复或切除半月板。结果膝关节功能按Lysholm评估,观察组优良率为92.00%,对照组为74.00%,两组膝关节功能优良率比较有统计学意义(x2=5.4767,P<0.05)。两组并发症比较:观察组发生各种并发症7例,对照组发生各种并发症10例,两组并发症比较无统计学意义(x2=1.7718,P>0.05)。结论对于膝关节损伤患者,使用关节镜微创加LISS钢板固定,膝关节功能恢复优于开放治疗好,功能恢复满意。%ObjectiveTo explore curative effect of arthroscopic minimal invasion combined with LISS steel plate in treatment of knee joint injuries.Methods 100 patients with knee joint injuries who were admitted to our department in our hospital from April 2010 to July 2014 were selected and allocated to the observation group and the control group. The observation group was treated with arthroscopic minimal invasion combined with LISS steel plate while the control group was treated with open reduction steel plate screw fixed fracture, repairing cruciate ligament and collateral ligament under direct vision and repairing or resecting meniscus.ResultsExcellent and good rate of knee joint function in the observation group was 92.00% while that in the control group was 74.00% which was evaluated by Lysholm. Excellent and good rate of knee joint function of two groups had statistical significance (x2=5.4767,P0.05).Conclusion Arthroscopic minimal invasion combined with LISS steel plate fixation in treatment with patients with knee joint injuries has a better and satisfying knee joint function recovery than open treatment.

  11. Late effects of gamma irradiation: the muscular fibrosis. Irradiation gamma et effets tardifs: la fibrose musculaire

    Energy Technology Data Exchange (ETDEWEB)

    Lefaix, J.L.; Daburon, F.; Martin, M.; Remy, J. (Centre d' Etudes Nucleaires de Fontenay-aux-Roses, 92 (FR). Inst. de Protection et de Surete Nucleaire)

    1990-06-01

    This study was performed on an experimental porcine model of acute local gamma irradiation to simulate accidents which occurred among humans. It enabled us to determine the development and the physiopathological characteristics of the fibrous tissue which developed in skeletal muscle. In the first month after irradiation, the strong inflammatory reaction which initiated the radiation induced fibrosis was characterized by edema as visualized on MRI imaging and X rays computed tomography and by acute phase reactant proteins changes, associated with elevations of local and general temperatures in irradiated animals. At the margin of the irradiated tissue myofibroblasts isolated among collagen bundles or grouped in nodullary reinforcements, are seen associated with intense capillary neogenesis. Several months after irradiation normal skeletal muscle was replaced by atrophic fibrosis delimited by an inflammatory perifibrotic tissue. The muscular fibrosis was characterized by a high density of myofibroblasts and by an inflammatory distribution pattern of collagen types I, III, IV, laminin, fibronectin and fibrinogen as visualized by immunohistochemical methods. Biochemical results showed an increase in collagen content and synthesis in fibrotic tissue whereas the cells in the perifibrotic zone synthesized more non collagenous proteins as compared with the normal muscle. The contributions of granulation tissue, cellular mediators and inhibition of muscular regeneration in the persistence of the invasive character of the muscular radiation induced fibrosis are discussed.

  12. Recommandations relatives a la prevention des maladies cardio-vasculaires en pratique clinique. Groupe de Travail Belge de Prevention des Maladies cardio-vasculaires.

    OpenAIRE

    G. De Backer; De Bacquer, D.; Brohet, C; De Ceukelier, S.; Franck, A.; Krzentowsky, G.; Legat, P.; Pochet, J M; Scheen, André

    2005-01-01

    These recommandations are largely based on the "European Guidelines on Cardiovascular Disease Prevention in Clinical Practice" proposed by the "Third Joint Task Force of European and other Societies on Cardiovascular Disease Prevention in Clinical Practice". The model used to assess the overall risk was adapted for Belgium. Otherwise, very few things were changed from the Exectutive Summary of the European Guidelines. Peer reviewed

  13. Nouveaux aspects cellulaires et moléculaires du remodelage vasculaire pulmonaire dans l’HTAP

    OpenAIRE

    Ranchoux, Benoît

    2015-01-01

    Pulmonary arterial hypertension (PAH) is a rare disease characterized by a severe modeling of the precapillary pulmonary arteries related to an endothelial cells (EC) dysfunction leading to vascular cell proliferation. This proliferation leads to a progressive obstruction of the distal pulmonary arterial bed and increases pulmonary vascular resistance. The resulting pulmonary hypertension (PH) leads to a progressive right ventricular hypertrophy, and subsequent right heart failure and death u...

  14. Influence de revetements bioactifs sur les cellules endotheliales: Vers des protheses vasculaires non thrombotiques

    Science.gov (United States)

    Fadlallah, Hicham

    Developing vascular prostheses of small diameter to replace vessels closed by atherosclerosis remains a challenge because of the risk of thrombosis. Seeding of endothelial cells, which have antithrombogenic properties, is a promising solution, but we must create surfaces which promote their adhesion and retention to resist shear stresses created by the blood flow on the surface. This master's project aimed at investigating the effect of a plasma polymerized coating rich in primary amines (called LP), with or without elements of the extracellular matrix (Fibronectin (FN) or chondroitin sulphate (CS)) on the endothelial cells and hemocompatibility of polyethylene terephthalate (PET). The adhesion, growth and retention of human umbilical vein endothelial cells (HUVECs) on PET and LP, in the presence and absence of FN or CS, have been studied. In addition, platelet adhesion on different surfaces was evaluated by a perfusion test with whole blood, platelets being previously labeled with rhodamine. Finally a double fluorescent labeling (using Cellview Maroon to mark the HUVECs and CD61 antibody for platelets) was developed to study the retention of endothelial cells, under blood flow and verify their non thrombogenic character. The results obtained show that both the LP coating and the adsorbed FN, strongly increase both the cellular adhesion and growth on PET; however they have no additional effect when the two are combined. They also augment cellular retention to surface, but this remains incomplete. Moreover we observed that the plasma coating (LP) greatly increases the thrombogenicity of the surface, with strong platelet adhesion and activation. This thrombogenicity is extremely reduced when endothelial cells cover the surface, but cell loss under the effect of shear produced by the perfusion creates significant areas of platelet adhesion. The grafting of CS on LP also permits good HUVECs adhesion, growth and retention under shear stress on HUVEC, with no difference from the LP alone. In addition, the CS sharply decreases the platelet adhesion, which is found below the value observed for PET. The double cell labeling also showed that cells adhered on LP+CS has an anti-thrombotic phenotype and can resist blood flow. These studies suggest that a coating of CS is a promising strategy for vascular prosthesis given the combination of the good adhesion of endothelial cells and the low thrombogenicity of the underlying surface. Keywords: vascular prostheses, polymers, bioactive coating, thrombogenicity, HUVECs.

  15. Imagerie Vasculaire du Sein par Rayons X, Tridimensionnelle, Quantitative et Faible Dose

    OpenAIRE

    Milioni de Carvalho, Pablo

    2014-01-01

    Background: Worldwide, breast cancer is the most common cancer and second deadliest cancer in women. Diagnostic imaging techniques are a critical part for screening, diagnosis, tumor staging and cancer therapy of the breast. Contrast-Enhanced Magnetic Resonance Imaging (CE-MRI) is the current standard imaging technique allowing detection of abnormal vascular development and lesion contrast uptake. CE-MRI is however very costly and not widely available. Moreover, its spatial resolution might n...

  16. Effet protecteur des acides gras contre le stress oxydatif : Implication en physiopathologie vasculaire

    Directory of Open Access Journals (Sweden)

    Negre-Salvayre Anne

    2005-09-01

    Full Text Available Oxidative stress play a major role in the genesis and the evolution of vascular pathologies. Recent data suggest that redox mechanisms are involved in the signaling network of vascular cells and the physiology of the vascular wall. Experimental cell models allow to analyse the biological effect of pro-oxidants, and the regulation exerted by antioxidants and cytoprotective agents. Fatty acids play a complex role in atherosclerosis, since they exhibit both anti and proatherogenic properties, as function of their concentration and insaturation level. Beside their role in cell metabolism and mitochondrial b-oxidation, fatty acids activate various signaling pathways, and could modulate intracellular oxidative stress via an uncoupling effect on mitochondria. We report here that fatty acids protect against mitochondrial oxidative stress by activating cellular glutathione peroxidase (GPX activity. This effect is independent of the chain length and unsaturation level. EGF receptor is activated by fatty acids and involved in their protective effect against mitochondrial oxidative stress and GPX activation, and similar protective results are observed with EGF. Oleic acid and EGF protect DNA against the formation of 8oxodG lesions occurring subsequently to oxidative stress. Taken together, this new ‘antioxidant’ and cytoprotective property of fatty acids and EGF could participate to the stabilization of atherosclerotic plaque, and the more general anti-atherogenic properties of oleic acid.

  17. Thalidomide et traitement des anomalies vasculaires de la maladie de Rendu Osler

    OpenAIRE

    Lebrin, Franck

    2013-01-01

    Au début des années 1960, la thalidomide, prescrite notamment pour combattre les nausées du premier trimestre de grossesse, a entraîné la naissance dans le monde de quelque 10 000 enfants porteurs de malformations des membres, provoquant un scandale de sécurité sanitaire sans précédent qui entraîna son retrait du marché. En dépit de cet effet tératogène, il était apparu dès cette époque que la thalidomide présentait néanmoins des propriétés pharmacologiques originales, en particulier comme mo...

  18. VenÀjÀ tiedeiden vÀlissÀ

    OpenAIRE

    KIVINEN, Markku

    2015-01-01

    Monitieteisyys ja tieteidenvÀlisyys eivÀt ole uusia ideoita. Viimeisen parinkymmenen vuoden aikana ne ovat kuitenkin saaneet uutta tuulta purjeisiinsa. Yhdysvalloissa Immanuel Wallerstein analysoi Gulbekianin komission raporttiin yhteiskuntatieteellisten disipliinien kehkeytymistÀ radikaalissa hengessÀ: perinteisen tieteenalakohtaisen tutkimuksen sijaan tulisi rikkoa disipliinien rajat ja sillÀ tavoin lisÀtÀ tieteen yhteiskunnallista relevanssia (Wallerstein 1996). Pian sama henki puhk...

  19. Osteosynthesis of a periprosthetic fracture of the proximal femur with the distal femur LISS system

    DEFF Research Database (Denmark)

    Tarnowski, Jan Robert; Holck, Kim

    2008-01-01

    In this case report, we show how it is possible to perform osteosynthesis using minimal invasive techniques instead of conventional methods. In this instance the osteosynthesis was performed on a patient in poor general condition who had presented a periprosthetic fracture of the proximal femur....... For the osteosynthesis the Less invasive Stabilization System intended for distal femur fractures was used with success....

  20. ISRO Resourcesat R1/R2 LISS-3 Level 1 Systematic Orthorectified

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Indian Remote Sensing (IRS), Resourcesat 1 and Resourcesat 2 are operated by the Indian Space Research Organisation (ISRO). The USGS in partnership with the...

  1. Large solar heating system with seasonal storage for buld drying in Lisse, the Netherlands

    NARCIS (Netherlands)

    Bokhoven, T.P.; Geus, A.C. de

    1996-01-01

    Within IEA Task 14 (Advanced Solar Systems) of the IEA Solar Heating and Cooling Programme a working group was established dealing with large advanced solar energy systems (the Large Systems Working group). The goal of this working group was to generate a common base of experiences for the design an

  2. Contribution à l'étude de l'étiopathogénie de l'hypertension artérielle par la mesure des flux de sodim et potassium érythroctaires

    OpenAIRE

    Krzesinski, Jean-Marie

    1986-01-01

    A la lumière d'arguments expérimentaux et d'observations épidémiologiques ou thérapeutiques, le lien entre l'hypertension artérielle essentielle et la consommation en sodium apparaît complexe et controversé. L'explication de l'augmentation des résistances vasculaires, anomalie hémodynamique observée dans cette maladie, nécessite l'étude du muscle lisse au niveau biochimique. Malheureusement, cette approche fondamentale est malaisée. En suggérant que les anomalies potentielles au niveau du mu...

  3. A propos d'activites musculaires locales contemporaines de la realisation phonatoire d'intentions differentes (Using Specific Speech Muscles to Realize Phonatory Intentions of the Speaker)

    Science.gov (United States)

    Wuilmart, Claude

    1970-01-01

    Study attempts to compare variations of certain acoustic parameters with those of electromyographic recordings of the digastric, orbicularis oris, and internal intercostal muscles in the case of three subjects using three different modes of expression. (DS)

  4. Prediction of vascular cerebral accidents by PET T.D.M. with {sup 18}F-F.D.G; Prediction des accidents vasculaires cerebraux par la TEP -TDM vasculaire au 18F-FDG

    Energy Technology Data Exchange (ETDEWEB)

    Grandpierre, S.; Chevalier, O.; Thomas, V.; Netter, F.; Meneroux, B.; Karcher, G.; Marie, P.Y. [Service de medecine nucleaire, CHU de Nancy, (France); Desandes, E. [departement d' informatique medical, centre Alexis-Vautrin, Nancy, (France)

    2009-05-15

    This study is the first to show a relationship between the vascular captation of the F.D.G. in PET and the risk of a later ischemic cerebral vascular accident. this relation seems particularly strong for the sources of the carotids junction, so that the PET with F.D.G. could be useful to evaluate the stability of atheromas injuries in this area. (N.C.)

  5. Le role de la chirurgie dans la prevention d'un accident vasculaire cerebral d'origine carotidienne

    OpenAIRE

    2003-01-01

    Early and late results of North American Trial (NASCET) demonstrate the efficacy of surgery to prevent major ipsilateral stroke in symptomatic patients; the benefit is proportional to the degree of stenosis. In asymptomatic patients, the benefit is real, but quantitavivement less pronounced. Peer reviewed

  6. Envenimation scorpionique compliqué d'un accident vasculaire cérébral ischemique

    OpenAIRE

    2015-01-01

    Les piqûres de scorpion sont dans un certain nombre de pays, un accident fréquemment rencontré, et un risque grave. Au Maroc, les données épidémiologiques établies par le centre anti-poison (CAPM) montrent que les piqûres scorpioniques se placent en tête de toutes les intoxications relevées par le centre (60%). Les envenimations scorpioniques posent un grand problème de santé publique. L'apparition de signes neurologiques lors d'une envenimation scorpionique témoigne d'une envenimation grave ...

  7. Estimation of spectral reflectance of snow from IRS-1D LISS-III sensor over the Himalayan terrain

    Indian Academy of Sciences (India)

    J Srinivasulu; A V Kulkarni

    2004-03-01

    Marine and Water Resources Group, Space Applications Centre, Ahmedabad, 380 015, India. The sensor onboard the satellite views the earth as a plain surface and consequently the satellite obtained spectral radiances cannot represent true values over a mountainous terrain. The relative magnitudes of terrain slope and its aspect with respect to the sun's position will determine the amount of direct solar radiation incident on an undulating surface. Estimation of spectral reflectance from satellite data forms an important component in many of the snow and glacier studies. The spectral reflectance of snow is influenced by its various parameters. The changes in snowpack characteristics as a result of various metamorphic processes, with age, can cause variations in its spectral reflectances. Since, the terrain geometry also modifies the amount of reflected radiation from a rugged surface, one has to correct the estimated spectral reflectances for terrain topography so as to use them in deriving the snowpack characteristics accurately. Also, the amounts of melt runoff originating from glaciers having different slopes and orientations will not be the same. Considering these aspects, a model has been developed to estimate the terrain corrected spectral reflectances over the Himalayan terrain using the Linear Imaging Self Scanner-III data of the Indian Remote Sensing Satellite. The model computes spectral reflectances from satellite based radiance measurements and includes the effect of the terrain topography on the incident solar radiation. The terrain slope and its aspect are generated from the digital elevation model of the region. The analysis carried out over the Beas Basin, Himachal Pradesh, India, indicated a variation of 22% in the amount of incident solar radiation for an increase of 10° in terrain slope. Further, the terrain with south-east aspect received maximum amount of solar radiation. The large differences observed between the uncorrected and terrain corrected reflectances in the shortwave infrared band (B5), which is not saturated over the snow covered region, suggest that the terrain slope and its aspect cannot be neglected in estimating the accurate spectral reflectances over the Himalayan terrain.

  8. Role of endovascular irradiation in the prevention of vascular restenosis following angioplasty; Role de la curietherapie endovasculaire dans la prevention de la restenose vasculaire apres angioplastie

    Energy Technology Data Exchange (ETDEWEB)

    Noel, G.; Feuvret, L.; Mazeron, J.J.; Pousset, F. [Hopital Pitie-Salpetriere, 75 - Paris (France); Bourhis, J.; Gerbaulet, A. [Institut Gustave Roussy, 94 - Villejuif (France); Popowski, Y. [Hopital Universitaire, Geneve (Switzerland)

    1998-07-01

    About 30% of patients who underwent percutaneous transluminal coronary angioplasty show evidence of restenosis, which appears to be independent of the angioplasty method used. The restenosis is due of two factors, Firstly migration of smooth vascular muscle cells of the vascular media to the intima and multiplication which lead to the formation of a neo-intima. Irradiation limits the proliferation by acting of the cells in the mitotic stage. The vascular target volume is not very thick and is difficult to define it, that why brachytherapy seems to be the best procedure to prevent restenosis. However, the development of this treatment present many difficulties. Different irradiation techniques have been studied. Such techniques include catheter containing radioactive sealed source, radioactive stent, or balloon containing radioactive liquid inside. Each of these methods have their own advantages, inconveniences, problems and risks. Radioisotope may be either beta or gamma emitters.Gamma emitter presents problems for radioprotection but the satisfactory dose distribution may be difficult to obtain using beta emitter. Choice of dose, dose rate and delay between the end of angioplasty and the beginning of brachytherapy is subject to some discuss. Animal experiments using radioisotope have shown reduction in cell proliferation. Human trials showed feasibility, safety of the method and real impact on restenosis prevention. However, long-term efficacy has not been proved because the follow-up of the patients is too short. A randomized trial of {sup 192}Ir brachytherapy for prevention of restenosis has recently shown the efficacy in short and median term. However, long term efficiency and secondary effects have not yet been established as the follow up time of this study is still too short. That is why, collaboration between cardiologists and radiotherapists and physicists is indispensable to enable the development of an optimal technique. (authors)

  9. L’étude ACCOMPLISH : remise en question des choix médicamenteux chez les patients hypertendus systoliques à haut risque cardio-vasculaire

    OpenAIRE

    Krzesinski, Jean-Marie; Scheen, André

    2009-01-01

    Arterial hypertension is an important cardiovascular risk factor. The benefit drawn from decreasing and normalizing the blood pressure level is indisputable. The ACCOMPLISH study performed in patients older than 65 with systolic hypertension and a high cardiovascular risk pointed out the interest of well choosing the antihypertensive combination to reduce this risk beyond the decrease of blood pressure. The association of benazepril (an angiotensin converting enzyme inhibitor or ACEI) and aml...

  10. Rééducation des troubles du langage: modalités et indications chez l'hémiplégique vasculaire adulte

    National Research Council Canada - National Science Library

    Beis, J.M

    2000-01-01

    ...~ initialedestroublesdulangage,delaformeclinique de l’aphasie et de la nature des resultats attendus en termes de readaptation permettraient de mieux cibler les programmes therapeutiques. Les differentes modalit& de traitement sont successivement envisagees. En l’absence de taxonomie et de terminologie aphasiologique unanimement reconnue, nous adoptons la classif...

  11. Le recensement des plantes vasculaires et les originalités du peuplement végétal des monts Loma en Sierra Leone (Afrique Occidentale

    Directory of Open Access Journals (Sweden)

    P. Jaeger

    1983-12-01

    Full Text Available A FLOR1STIC INVENTORY OF THE LOMA MOUNTAINS IN SIERRA LEONE Our surveys in Sierra Leone of the flora of the Loma Mountains and the foothill country have enabled us to produce an inventory of the I 576 species, subspecies or varieties of Angiosperms belonging to 757 genera and 135 families. Gymnosperms are lacking. As in any other natural region, the Loma flora is the result of a long and complex process which took place in much earlier times. Under the influence of climatic factors, migration, speciation and also anthropological action, floristic elements with very different origins have ultimately arranged themselves into a particularly diversified but unstable mosaic and it is for us to unravel the mechanisms that have brought this about.

  12. Un modèle animal simple pour l’apprentissage des techniques de microanastomoses vasculaires de congruences différentes

    Science.gov (United States)

    Leclère, Franck Marie P; Kolb, Frédéric; Lewbart, Gregory A; Casoli, Vincent; Vögelin, Esther

    2014-01-01

    INTRODUCTION: Depuis les premiers travaux de Jacobson et Suarez, la microchirurgie a considérablement évolué et celle-ci est devenue omniprésente en chirurgie plastique comme dans les autres spécialités chirurgicales. L’apprentissage au laboratoire des techniques de base est nécessaire avant d’envisager l’exécution de procédures cliniques. Dans cet article, nous avons évalué un modèle animal permettant de fournir une solution aux problèmes suivants : règles d’éthique, coût, anesthésie, temps nécessaire à la formation. MATÉRIEL ET MÉTHODE: Entre juillet et septembre 2012, 150 simulations de microanastomoses de vaisseaux incongruents par la technique d’Harashina ont été réalisées sur 182 Lumbricus terrestris. L’entrainement a été divisé en 10 périodes de 7 jours comprenant chacune 15 simulations de microanastomoses de vaisseaux incongruents, dont le plus petit diamètre était supérieur à 1,5 mm (n = 5), compris entre 1,0 mm et 1,5 mm (n = 5), ou inférieur à 1,0 mm (n = 5). Un modèle linéaire avec le numéro de la période comme variable principale et la taille de l’animal comme facteur étaient utilisés afin de déterminer la tendance de la durée d’exécution de l’exercice microchirurgical ainsi que les différences entre les sous-groupes de tailles différentes au cours des périodes d’apprentissages. RÉSULTATS: Le modèle linéaire montre une tendance significative (P < 0,001) à la réduction du temps opératoire durant le décours du training ainsi qu’une différence significative entre les groupes d’animaux de tailles différentes. Pour les microanastomoses de taille supérieure à 1,5 mm, le temps d’anastomose moyen est passé de 19,6±1,9 min à 12,6±0,7 min entre la première et la dernière semaine de formation (diminution de 35,7 %). Pour un training avec des vaisseaux de diamètre inférieur, les résultats montraient une diminution dans le temps d’exécution de 36,1 % (diamètre compris entre 1,0 mm et 1,5 mm) et 40,6 % (diamètre <1.0 mm) entre la première et la dernière semaine de training. L’étude montre également une nette amélioration de la dextérité et de la vitesse d’exécution des noeuds. CONCLUSION: Lumbricus terrestris est un modèle fiable pour la formation microchirurgicale. Les nombreux avantages que nous avons soulignés dans cette étude suggèrent que l’utilisation de ce modèle invertébré va considérablement se développer dans un avenir proche. PMID:25789274

  13. La surveillance du retard de croissance intra-utérin d'origine vasculaire par la vélocimétrie du Doppler ombilical

    OpenAIRE

    2012-01-01

    Intrauterine growth restriction of vascular origin monitored by umbilical Doppler velocimetry Fetuses with early onset intrauterine growth restriction are at increased risk for adverse short and long term outcomes. The umbilical artery Doppler velocimetry used to monitor fetuses with intrauterine growth restriction (IUGR) allows a reduction in perinatal morbidity and mortality. To monitor fetuses with IUGR, it is recommended to sample a free-floating loop of the umbilical cord as a measuremen...

  14. La préservation du capital vasculaire au CHU Ibn Sina de Rabat-Maroc: rôle de l’infirmier

    Science.gov (United States)

    Bouattar, Tarik; Bezzaz, Aicha; Abdellaoui, Khalil; Lamchahab, Fatima Ezzahra; Benamar, Loubna; Ezaitouni, Fatima; Hassam, Badredine; Bayahia, Rabia; Ouzeddoun, Naima

    2012-01-01

    Introduction Tout patient ayant une maladie chronique nécessitant des prélèvements sanguins répétés ou des traitements par voie veineuse ou susceptible d’évoluer vers l’insuffisance rénale chronique, doit bénéficier d’une stratégie de préservation de son réseau veineux. Le but de ce travail etait de déterminer le rôle de l’infirmier dans la protection du réseau veineux superficiel. Méthodes Etude transversale réalisée au mois d’Avril 2010 à l’hôpital Ibn Sina de Rabat ayant intéressée les infirmiers exerçant dans différents services prenant en charge des patients ayant des pathologies rénales chroniques ou une maladie générale susceptible de se compliquer d’atteinte rénale. Résultats Parmi les 80 infirmiers sollicités, 66 ont complété le questionnaire avec un âge moyen de 42,7 ±11ans et un sex-ratio à 0,7. L’ancienneté moyenne en soins était de 227,7 ± 116,7 mois. 37 % des infirmiers n’étaient pas informés sur la préservation du capital veineux. Le membre supérieur droit était ponctionné dans 92,3% des cas. Le site de ponction le plus utilisé était le dos de la main dans 84,6 % des cas. La dilatation des veines par le réchauffement était notée dans 63,3% des cas, par passage d’alcool dans 54,5% des cas et l’emploi du garrot était retrouvé dans 95,5% des cas. Les venojects étaient de 18 gauge dans 18,2 % des cas et de 21 gauge dans 81,8% des cas. Les intranules étaient de 18 gauge dans 78,8% des cas et de 20 gauge dans 21,2 % des cas. Durant les six derniers mois avant l’étude, les complications au niveau du site de ponction étaient notées dans 41 % des cas. Conclusion L’information et l’éducation du personnel paramédical sont obligatoires ainsi que l’utilisation des cathéters veineux de petit calibre afin d’assurer cette protection. PMID:22593793

  15. Utilization of deuterium for the study of ingested water absorption during muscular exercise; Utilisation du deuterium pour l`etude de l`absorption de l`eau ingeree pendant l`exercice musculaire

    Energy Technology Data Exchange (ETDEWEB)

    Melin, B.; Jimenez, C.; Savourey, G.; Bittel, J.; Bernard, O.; Charpenet, A.; Regnard, A.; Pouzeratte, N. [CRSSA, 38 - La Tronche (France); Monnerot, P. [Societe Anonyme des Eaux Minerales d`Evian, 74 - Evian (France); Antoine, J.M. [Boussois-Souchon-Neuvesel (BSN), 75 - Paris (France)

    1994-12-31

    A long physical exercise-heat exposure is accompanied with massive hydro-saline losses, due to sudation, inducing a lowering of the physical performance. A stable isotope tracer technique, with deuterium in the form of deuterium oxide, is used to study the effect of ingested water quality (pure water, water and sodic and/or energetic additives) on the speed at which ingested water passes in the vascular sector during such an exercise in preliminarily dehydrated human beings. 2 figs., 12 refs.

  16. Influence d'une microsporidiose à Thelohania contejeani sur le métabolisme des acides gras totaux, musculaires, hépatopancréatiques et hémolymphatiques chez l'Écrevisse Austropotamobius pallipes le reboulet, 1858.

    Science.gov (United States)

    Kabre, G

    1988-03-01

    The fatty acids of muscular, hepatopancreatic, hemolymphatic of complete lipids of A. pallipes have a high degree of insaturation (40-50%). Palmitic, eicosapentenoïc, arachidonic, stearic, oleic acids are more than 90% of the acids. Into the parasited crayfishes, there is a decrease of the amount of the non-saturated acids and an increase of saturated acids rate.

  17. Développement de modèles animaux de maladies génétiques des systèmes cardiovasculaire et musculaire chez le poisson-zèbre

    OpenAIRE

    Ramspacher, Caroline

    2014-01-01

    The numerous advantages of zebrafish were used to study two hereditary diseases: desminopathy and pulmonary veno-occlusive disease (PVOD). Desminopathy is a myofibrillar myopathy characterized by the presence of granulofilamentous aggregates. Two models of loss and gain of function of desmin showed the implication of both loss of functional desmin and presence of desmin aggregates in desminopathy clinical manifestations. Phenotypes observed in these models include in particular a perturbation...

  18. Muscular fixing of the H.M.D.P. {sup 99m}Tc induced by a statin, rosuvastatin or crestor: clinical case; Fixation musculaire du HMDP Tc99m induite par une statine, la rosuvastatine ou Crestor: cas clinique

    Energy Technology Data Exchange (ETDEWEB)

    Bourahla, K.; Hassler, S.; Schneegans, O.; Gyen, L.N. [CLCC Paul-Strauss, Service de medecine nucleaire, 67 - Strasbourg (France)

    2010-07-01

    Myositis induced by statins in treatment for hypercholesterolemia is a special clinical entity that may be encountered during an exploration by bone scintigraphy. We present the case of a muscle fixing observed in bone scan in a patient treated with rosuvastatin (Crestor). Muscular extra bone fixing of hydroxy-methane diphosphonate (H.M.D.P.) {sup 99m}T in patients referred for staging of prostate carcinoma, patients sometimes also treated for high cholesterol may be iatrogenic due to taking statins. A simple history may then allow its identification, although it remains asymptomatic. (N.C.)

  19. Importance de l'activité physique, de l'exercice musculaire et du sommeil sur le risque cardiovasculaire et métabolique de la personne en surpoids ou obèse

    OpenAIRE

    Mendelson, Monique

    2014-01-01

    Obesity is a major public health issue and is associated with increased cardiovascular and metabolic morbidity. Recent studies underline the potential bidirectional association between sleep and obesity: sleep seems to contribute to the pathogenesis of obesity and obesity also appears to play an etiological role in the development of sleep disturbances, such as obstructive sleep apnea (OSA). Physical activity is an important modality for the treatment of obesity and OSA and can contribute to ...

  20. Insulinorésistance musculaire induite par les céramides : étude des mécanismes d'action et de l'implication du transporteur CERT

    OpenAIRE

    Mahfouz, Rana

    2015-01-01

    Obesity and type 2 diabetes are associated with a sedentary lifestyle and a diet rich in fat. Indeed, saturated fatty acids accumulate in non-adipose tissue such as skeletal muscle to generate lipids called ceramides (CER). My thesis project was divided into two parts with the objective to prevent CER to act. We have shown that, depending on the structure of the plasma membrane, CER alter the insulin signaling pathway by targeting PKB, a key insulin signalling protein, via a PKCζ pathway in L...

  1. Integrated approach of the metabolism and the muscle perfusion in imaging and magnetic resonance spectroscopy; Approche integree du metabolisme et de la perfusion musculaire en imagerie et spectroscopie par resonance magnetique nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Brillault-Salvat, C

    1997-12-16

    Oxygen is necessary to the tissue life. Every step from its transport of the ambient medium to its consumption by cells are essential to the right functioning of organism. The involved phenomena are complex and use numerous different mechanisms. In order to better understand the functioning, it has been developed a non traumatic, non irradiating and quantitative method that allows to measure in the same time several determinants of the tissue oxygenation. (N.C.)

  2. Modélisation vectorielle et commande de machines polyphasées à pôles lisses alimentées par onduleur de tension

    OpenAIRE

    SEMAIL, Eric; Kestelyn, Xavier

    2010-01-01

    Ce chapitre traite de la modélisation et de la commande de machines électriques à plus de deux courants indépendants alimentées par onduleur de tension. Une approche vectorielle générale permettant de généraliser le concept de machine diphasée équivalente utilisé pour les machines triphasées est présentée et appliquée au cas d’une machine synchrone prototype à aimants permanents cinq phases alimentée soit par 5 bras d’onduleurs.

  3. Commande vectorielle de la machine a reluctance variable à stator lisse. Prise en compte de la saturation et de l'amortissement

    OpenAIRE

    Tounzi, A.; Meibody-Tabar, F.; Sargos, F.

    1997-01-01

    This paper deals with the field-oriented control of a smooth stator, non excited salient rotor synchronous machine. First, a nonlinear modelling of the machine, taking into account both damping and saturation effects, is developed in PARK's rotor-bound frame. Then, a vector control strategy, which maintains a constant saturation level in the machine, is set-up. This strategy, wich consists in keeping the stator direct current at a high constant value, allows to linearize the model of the mach...

  4. Evaporation of refrigerant HFC 407C on plain tubes or at an improved surface; Evaporation du refrigerant HFC 407C sur des tubes lisses ou a surface amelioree

    Energy Technology Data Exchange (ETDEWEB)

    Zuercher, O.; Favrat, D.; Thome, J.R.; Kattan, N.; Nidegger, E. [Ecole polytechnique federale, Lab. d`energetique industrielle, Lausanne (Switzerland)

    1996-11-15

    The substitution of CFC refrigerants in refrigeration systems, heat pumps and organic Rankine cycles for heat recovery, requires good methods for predicting heat transfer of substitute fluids. The measurements in the LENI test facility (concentric tubes with water flowing in a counter-current flow) with HFC 407C, HFC 134a, HCFC 123, HFC 404a and HFC/HCFC 402A provide a new data bank for new refrigerants, and allow a coherent comparison with old refrigerants CFC 11, CFC 12, CFC/HCFC 502 and with existing correlations. The existing correlations were found to be inadequate. Because of this work, an improved flow pattern map and flow boiling model were developed, which resulted in a substantial progress in the accurate predict of heat transfer in plain, horizontal tubes for refrigerants without oil. The Kattan et al. correlation was programmed to calculate and compare predicted heat transfer coefficients to the new HFC 407C test data. The flow pattern map proposed by Kattan et al. was also programmed and compared to flow regimes observed for HFC 407C. It predicted the HFC 407C flow pattern data quite accurately. The original objective of the HFC 407C measurements was the validation of the Kattan et al. correlation applied to a zeotropic refrigerant blend. Local flow boiling heat transfer coefficients were measured for HFC 407C evaporating inside a microfin and a plain tube. In addition, microfin heat transfer augmentation relative to a plain tube was investigated. The presence of oil in the evaporator had a complex effect on heat transfer coefficients. Local flow boiling heat transfer coefficients were measured for refrigerant HFC 407C ester oil mixtures (Mobil EAL Arctic 68). A new thermodynamic approach for modeling mixtures of zeotropic refrigerant blends and lubricating oils was also developed. (author) figs., tabs., 14 refs.

  5. Onderzoek in het kader van het ‘Actieplan Minder Virus in Tulp’, uitgevoerd door PPO- Bloembollen, Lisse en Proeftuin Zwaagdijk in 2013 en 2014

    NARCIS (Netherlands)

    Dam, van M.F.N.; Verbeek, M.; Stijger, I.; Kreuk, F.

    2015-01-01

    Doelstellingen van het Actieplan “Minder virus in Tulp” zijn: Dit project organiseert de opstart en de uitvoering van een actieplan dat leidt tot minder virus in tulp in een economisch rendabele teelt. De aandacht ligt met name bij TBV, TVX, Augustaziek, ArMV en LSV. Uitvoering van het actieplan moe

  6. Impact d'un programme d'éducation thérapeutique du patient à l'activité physique chez des patients en phase subaiguë d'accident vasculaire cérébral

    OpenAIRE

    Kammoun, Benjamin

    2015-01-01

    In France, we estimate at 150,000 the number of cerebral vascular accident per year. With a cost of 8.3 billion euros, it has become a public health issue. The expenses are, among others, related to legacy, as 43.2% leave hospital being physically dependent.These effects will aftereffect will cause limitations, causing a vicious cycle of inactivity and deconditioning bringing. To fight against this deconditioning, it seems appropriate to follow the recommendations of learned societies in term...

  7. Chez une personne atteinte d’accident vasculaire cérébral vivant à domicile, quel est le rôle de l’infirmière face à l’incertitude de l’avenir

    OpenAIRE

    Mayor, Véronique; Minotti, Elisa; Goumoëns, Véronique de

    2016-01-01

    Contexte : L’AVC est la cause majeure d’invalidité physique, émotionnelle et cognitive et de diminution de la qualité de vie chez l’adulte. De par la nature soudaine et imprévisible de l’AVC, l’incertitude fait partie intégrante de la vie des malades. Objectif : L’objectif de cette revue de littérature est de mettre en avant les différents rôles d’une infirmière afin d’aider les patients ayant subi un AVC, une fois leur retour à domicile, dans la gestion de l’incertitude. Méthode : Deux bases...

  8. Evaluation of inflammatory cells in abdominal aortic aneurysmal wall by tomography emission positron; Anevrisme de l aorte abdominale et inflammation vasculaire: place de la tomographie par emission de positons

    Energy Technology Data Exchange (ETDEWEB)

    Sakalihasan, N. [Service de chirurgie cardiovasculaire et thoracique, CHU de liege, domaine universitaire du Sart Tilman, batimant B-35, 4000 liege 1, (Belgium); Hustinx, R. [Service de medecine nucleaire, CHU de Liege, (Belgium); Gomez, P.; Defraigne, J.O. [Departement de medecine nucleaire, CHU de Liege, (Belgium)

    2009-05-15

    The objective was to identify the methods of functional imaging and the molecular markers that could help to predict the imminence of a rupture in abdominal aortic aneurysm. The potential of the PET was studied to detect a hyper-metabolic state in the aneurysm wall and this information was connected with the evolution of the disease. An uptake of F.D.G. in the aneurysm wall reflects the presence of a great density of inflammatory cells (macrophages, lymphocytes, polymorphonuclear cells). It has been observed an accumulation of polymorphonuclear cells accompanying a dense infiltration of macrophages and lymphocytes only in the site of break. Our preliminary study and our most recent observations (not yet published) suggest a possible relationship between the F.G.D. captation by the aneurysm wall and the start of the activity of the matrix metallo-proteinases leading to the break. The PET scan could be useful for high risk patients because a positive PET imaging stigmatizes a greater risk of break. consequently, the positive PET imaging represents a diagnosis argument to proceed to a surgical operation, despite the age of the patient, the size of the abdominal aorta aneurysm and the higher operative risk. however, more data to better define the criteria of using the PET/T.D.M. in the evaluation of abdominal aorta aneurysm and to determine its exact contribution in the treatment determination. (N.C.)

  9. Commande en position et vitesse sans capteur mécanique de moteurs synchrones à aimants permanents à pôles lisses : Application à un actionneur électromécanique pour aileron

    OpenAIRE

    Zgorski, Aloïs

    2013-01-01

    The issue of sensorless control of permanent magnet synchronous machine (PMSM) has been well studied in the field of automation and electrical engineering. In the following work, we were interested in the peculiar problem of low-speed sensorless control of surface PMSM. The objective is to o er a new method for the position control of an industrial electro-mechanical actuator, considering an aeronautical context (a flap actuator). First, modeling and observability analyses of surface (non-sal...

  10. About a case of pathological muscular hyper fixations in PET-F.D.G.. Diagnosis discussions and reminder of the main differential diagnosis; A propos d'un cas d'hyperfixations musculaires pathologiques en TEP-FDG. Discussion diagnostique et rappel des principaux diagnostics differentiels

    Energy Technology Data Exchange (ETDEWEB)

    Colavolpe, C.; Puech, J.B.; Mundler, O. [CHU Timone, Service de medecine nucleaire, 13 - Marseille (France); Belenotti, P.; Sevy, A.; Ene, N.; Serratrice, J. [CHU Timone, Service de medecine interne, 13 - Marseille (France); Verschueren, A.; Attarian, S. [CHU Timone, Service de neurologie maladies neuromusculaires, 13 - Marseille (France); Azulay, J.P. [CHU Timone, Service de neurologie pathologies du mouvement, 13 - Marseille (France)

    2010-07-01

    The muscle hyper fixing are common in PET-F.D.G.. Their interpretation requires a good knowledge of the main artifactual and pathological causes and the correlation with other clinical and para clinical data. (N.C.)

  11. Muscular scintigraphy at effort and the index of systolic pressure (ISP) at rest in the detection of obliterative arteriopathy of inferior limbs (OAIL); Scintigraphie musculaire a l`effort et index de pression systolique (IPS) au repos dans la detection de l`arteriopathie obliterante des members inferieurs (AOMI)

    Energy Technology Data Exchange (ETDEWEB)

    Tellier, P.; Lecouffe, P.; Aquilanti, S.; Vasseur, C. [Centre de Medecine Nucleaire de l`Artois, Arras (France)

    1997-12-31

    The diminution of fixation of {sup 201}Tl at effort on the leg muscles can reveal a debuting or confirmed OAIL. The same is valid for the ISP. This study compares the 2 techniques in asymptomatic subjects, the ISP being used as `reference method`. We have measured in 105 patients the ISP at rest (posterior-tibial pressure/humeral pressure, left and right), the asymmetry index (AI), defined as fixation in a limb divided by fixation in the other, and the segmentary fixation index (SFI), defined as fixation in a limb divided by fixation in the entire body, after the injection of 92 MBq of {sup 201}Tl at the moment of a maximal effort test, achieved on a running belt. An ISP < 0.90 was considered as pathologic (13/105 i.e. 12.4%). A table is presented, giving the percentage values of AI, SFI and AI + SFI corresponding to the sensitivity, specificity, positive predictive value and negative predictive value. In conclusion, the sensitivity of the muscular scintigraphy at effort in detection of OAIL, characterized by a significant diminished ISP at rest, varies according to the criteria of positivity. The AIs is less sensible but more specific. The sensitivity is maximal (100%) when one couples the 2 indices, to detriment of specificity (55%). The best compromise is provided by the ISF. Although the positivity in case of normal at-rest ISP is rather frequent. The significance of the muscular anomalies detected at effort remains to be elucidated, taking into account the limits of ISP

  12. Diminution de la teneur en cardiolipide, un phospholipide clé dans la régulation de la fonction énergétique, dans un modèle d’hypertrophie musculaire lié à l’invalidation de la myostatine

    OpenAIRE

    Baati, Narjes; Fouret, Gilles; Vernus, Barbara; Goustard, Benedicte; Barea, Bruno; Coudray , Charles; Bonnieu, Anne; Ramonatxo, Christelle; Feillet Coudray, Christine

    2016-01-01

    Introduction et but de l’étude : La mitochondrie est la centrale énergétique de nos cellules, leur fournissant l’énergie nécessaire à son activité métabolique. Toute altération de cette centrale énergétique a pour conséquence une baisse de production d’énergie et affecte préférentiellement les tissus qui en sont fortement consommateurs. Des travaux récents montrent un rôle central du cardiolipide (CL), un phospholipide exclusivement mitochondrial, dans la régulation de la fonction énergétique...

  13. Isocinétisme et complexe articulaire de l’épaule.

    OpenAIRE

    Forthomme, Bénédicte; Crielaard, Jean-Michel; Croisier, Jean-Louis

    2008-01-01

    1. MISE AU POINT METHODOLOGIQUE – INTRODUCTION La fonction musculaire de l’épaule conditionne sa stabilité et participe au niveau de performance sportive [2,3,7]. L’évaluation de la force maximale apparaît essentielle dans divers contextes pathologiques : conflit sous-coraco-acromial, épaule instable, atteinte neurologique, contexte chirurgical et transfert musculaire, surmenage sportif ou professionnel. Si la littérature apparaît consensuelle dans le cas du genou, l’exploration isociné...

  14. School-Aged Outcomes After Neonatal Arterial Ischemic Stroke

    OpenAIRE

    Theresa Czech; Pardo, Andrea C.

    2016-01-01

    Investigators from the Accident Vasculaire Cérébral de nouveau-né (AVCnn) Study Group, a multicenter registry in France, examined outcomes at 7 years of age in children previously identified with neonatal arterial ischemic stroke (NAIS).

  15. School-Aged Outcomes After Neonatal Arterial Ischemic Stroke.

    Science.gov (United States)

    Czech, Theresa; Pardo, Andrea C

    2016-02-01

    Investigators from the Accident Vasculaire Cérébral de nouveau-né (AVCnn) Study Group, a multicenter registry in France, examined outcomes at 7 years of age in children previously identified with neonatal arterial ischemic stroke (NAIS).

  16. Role of Transglutaminase 2 in vascular remodeling

    NARCIS (Netherlands)

    van den Akker, H.H.O.

    2011-01-01

    Verschillende vasculaire ziektebeelden, waaronder hoge bloeddruk en verminderde doorbloeding, leiden tot vernauwing van slagadertjes. Het enzym Transglutaminase 2 (TG2) speelt hierbij een belangrijke rol. Jeroen van den Akker onderzocht het achterliggende proces en ontdekte een nieuwe activatieroute

  17. Use of HMPAO-{sup 99m}Tc in radio-labelling endothelial cells: application to the study of the behaviour of endothelialized vascular prostheses under shearing constraint; Utilisation de HMPAO-{sup 99m}Tc pour le radio-marquage de cellules endotheliales: application pour etudier le comportement de protheses vasculaires endothelialisees sous contraintes de cisaillement

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, Ph.; Bareille, R.; Brouillaud, B.; Barthe, N.; Rouais, F.; Bordenave, L. [Laboratoire de Biophisique, CHU-Bordeaux, 33076 Bordeaux (France)

    1997-12-31

    Insemination of the low-caliber vascular prostheses at the level of their endo-luminal surfaces by a monolayer of endothelial cells (EC) prior to their implantation diminishes their thrombogen character and increases their long-term expectation of permeability in humans. The aptitude of EC of remaining adherent to their support when exposed to the constraints of circulatory flux must be studied in vitro and all the authors quantify these adherence by the measurement of the loss of gamma activity of the vascular prosthesis after radiolabelling of EC by {sup 111}In oxinate. In this work EC of human origin, adherent to the culture surfaces were radiolabelled by HMPAO-{sup 99m}Tc and optimal conditions of the labelling were determined: the effect of increasing concentrations of HMPAO and increasing activities of HMPAO-{sup 99m}Tc on the viability and metabolic activity of EC; the influence of the temperature and of the time of touching on the labelling yield. Subsequently, this conditions were applied to EC having cultivated a innovative vascular prosthesis. Surface micro-auto-radiographies were realized. The best compromise was obtained with 10 MBq/10{sup 6} EC (40 {mu}g of HMPAO/10{sup 6} EC) corresponding to a labelling yield of 13.7 {+-} 0.7 after 3 hours of contact at 37 deg. C. The micro-auto-radiographies allow visualization of the intracellular radioactivity distribution. The study of adherence of EC to the vascular prosthesis, under shearing constraints, by means of a radiotracer provides numerous advantages vs current utilisation of {sup 111}In oxinate

  18. Impact of the SPECT/T.D.M. with leukocytes labelled with {sup 99m}Tc-H.M.P.A.O. in the detection of abdomen vascular prosthesis infections; Impact de la TEMP/TDM aux leucocytes marques au 99mTc-HMPAO dans la detection des infections de protheses vasculaires abdominales

    Energy Technology Data Exchange (ETDEWEB)

    Mortazavi-Jehanno, N.; Ben Ali, K.; Poisson, T.; Sarda-Mantel, L.; Le Guludec, D.; Lebtahi, R. [Medecine nucleaire, hopital Bichat, AP-HP, Paris, (France)

    2009-05-15

    Objectives: to enlighten the contribution of specificity of SPECT/T.D.M. with leucocytes labelled with {sup 99m}Tc-H.M.P.A.O. in the detection of abdomen vascular prosthesis infection and the interest to free oneself of physiological digestive background noise artefacts.Conclusions: The scintigraphy with leukocytes labelled with {sup 99m}Tc-H.M.P.A.O. is a noticeable examination for the detection of infectious centres. The contribution of the SPECT/T.D.M. at 24 hours in the detection of infectious centres of vascular prosthesis allows to increase the examination specificity, especially for the abdomen vascular prosthesis, by freeing oneself of the physiological digestive background noise able to induce false positives, and allows a precise anatomical location with a therapy impact for the patient. (N.C.)

  19. Infection of vascular prosthesis: contribution of the PET/F.D.G. and scintigraphy with labelled polynuclear (planar + SPECT- CT): about 12 cases;Infection de prothese vasculaire: apport de la TEP-FDG et de la scintigraphie aux polynucleaires marques (planaire + TEMP-TDM): a propos de 12 cas

    Energy Technology Data Exchange (ETDEWEB)

    Agius, C.; Rakotonirina, H.; Vervueren, L.; Lacoeuille, F.; Le Jeune, J.J.; Couturier, O. [CHU d' Angers, Service de medecine nucleaire, 49 - Angers (France)

    2010-05-15

    This preliminary study suggests the positive good diagnostic value of PET-F.D.G. and labelled polynuclear scintigraphy (L.P.N.S.) in hybrid imaging in the diagnostic of vascular prostheses infection. PET appears more sensitive but less specific, more extensive series are needed to confirm these data. (N.C.)

  20. Tuméfaction du muscle pectoral révélant une tuberculose ...

    African Journals Online (AJOL)

    Tuméfaction du muscle pectoral révélant une tuberculose musculaire isolée. ... English Abstract. Soft tissue tuberculosis is one of the rare forms of extrapulmonary tuberculosis. Furthermore ... The diagnosis was mainly based on histology.

  1. Heat transfer study of a two-phase refrigerant with liquid-solid phase change inside a smooth plates heat exchanger; Etude des transferts de chaleur d'un fluide frigoporteur diphasique a changement de phase liquide-solide dans un echangeur a plaques lisses

    Energy Technology Data Exchange (ETDEWEB)

    Demasles, H.

    2002-05-15

    The purpose of the work is to study two-phase mixture heat exchange composed of water particles suspended in silicone oil circulating in a closed loop. Water, contained in polymer porous matrix, is freezing by successive passages in plane plate heat exchanger. Thermo-hydraulic literature data analysis about these fluids in exchangers shows important blanks in exchange coefficient and pressure drop forecast methods and in experimental data. Experimental results, issued of global energy balance on a test section specifically conceived and made for this study, show doping effect on exchange coefficient. Before phase change, micro-convective effects of rotating particles improve exchange coefficient of 2,3 factor. Supplementary enhancement included between 2 and 16 appeared during phase change. Trial measured discrepancy are certainly induced by bed layer formation due to low flow speed. At the end of particle freezing, when latent heat is not involved anymore in exchange enhancement, important heat transfer reduction is observed. This is attributed to the cooling suspension rheological evolution and the change of flow particle distribution. Modelling results corroborate heat exchange improvement due to phase change: particles act as sources when discharging there latent heat. They stop fluid temperature dropping and enable to keep a high wall temperature gradient. A deepened suspension rheological study is necessary for a better understanding of observed phenomenon, nevertheless these first results show already an important energetic profit brings by particles in range temperature of 0 and -6 deg C. (author)

  2. Un stress oxydant chronique est associé à une amelioration de la sensibilité à l’insuline et des fonctions mitochondrialesdans le muscle squelettique de souris SAMP8

    OpenAIRE

    Barquissau, Valentin; Denis, Philippe; Jouve, Chrystele; Patrac, Véronique; Rigaudière, Jean-Paul; Feillet Coudray, Christine; Galinier, A; Rieusset, Jennifer; Chardigny, Jean-Michel; Morio, Béatrice

    2012-01-01

    De nombreuses études suggèrent que les espèces réactives del’oxygène participent à l’étiologie du diabète de type 2. Ce travail a pour objectifd’étudier l’effet d’un stress oxydant chronique sur le développement de l’insulino-résistance et sur les adaptations des fonctions mitochondriales musculaires.

  3. Surgery in the Elderly: Does age matter?

    NARCIS (Netherlands)

    K. de Leur (Kevin)

    2015-01-01

    markdownabstract__Abstract__ De demografische verschuiving in het aantal ouderen zorgt voor een oudere behandelgroep. De chirurgische behandeling van vasculaire en trauma gerelateerde aandoeningen in deze oudere populatie is niet eenvoudig. Zorgvuldige patiëntselectie zou wel eens de sleutel kunnen

  4. African Journal of Neurological Sciences - 2009 Vol. 28 No 1

    African Journals Online (AJOL)

    mortalité dans le monde et la 1ère cause de handicap acquis chez l'adulte. ... avec d'autres facteurs de risque vasculaires, tels que l'hypertension artérielle et .... l'alcool, activité physique régulière, perte de poids et régime alimentaire adapté, ...

  5. Un AVC ischémique a IRM cérébrale normale: à propos d’un cas

    Science.gov (United States)

    Lemahafaka, Glorien; Camara, Ansoumane; Rajaonarison, Lala; Vallet, Francis

    2016-01-01

    L'IRM cérébrale reste un examen de référence pour diagnostiquer un accident vasculaire cérébrale. La sensibilité au cours d'un accident vasculaire cérébrale à la phase aigüe n'atteint pas toujours 100%. Nous rapportons un cas d'un accident vasculaire cérébral ischémique à IRM cérébrale initiale normale. L'IRM cérébrale normale à la phase précoce d'un accident vasculaire cérébrale pose un doute sur l'indication de la thrombolyse qui est le traitement de référence en cas d'embole cérébrale. La répétition d'un examen avec coupe fine, en séquence de diffusion B2000 permettrait de mettre en évidence l'infarctus de très petit volume non visualisé par IRM cérébrale conventionnelle. PMID:28154714

  6. African Journal of Neurological Sciences - 2009 Vol. 28 No 1

    African Journals Online (AJOL)

    , ... diabète et son association avec d'autres facteurs de risque vasculaires, tels que l'hypertension artérielle et ... Le traitement le plus efficace demeure la prévention .... l'alcool, activité physique régulière, perte de poids et régime alimentaire ...

  7. De herziene ergotherapierichtlijn CVA

    NARCIS (Netherlands)

    Edith Cup; Ton Satink; Yvonne Heerkens

    2012-01-01

    De herziene ergotherapierichtlijn CVA (Cerebraal Vasculair Accident) is volop in ontwikkeling en wordt in maart 2013 gepresenteerd. De herziene richtlijn is vanzelfsprekend nóg meer evidence-based, cliëntgecentreerd, op het handelen gericht en in de context gesitueerd. Deze column heeft een

  8. Studies on the Mechanism and Prevention of Decompression Sickness.

    Science.gov (United States)

    1982-07-12

    1968 - February 28, 1982 b i TABLE OF CONTENTS Page PREFACE ------------------------------------------------------- III INTRODUCTION...Table of Contents (continued) Pg Dysbaric Osteonecrosis: Etiological and Pathogenetic Concepts-- 123 Dysbaric Osteonecrosis in Mice...des lesions vasculaires doies aux bUlles. Ccs observations peuvent contribuer At l’Ouci- dation de la pathog~nie de la maladie de decompression, ct

  9. Case series

    African Journals Online (AJOL)

    abp

    10 mai 2016 ... work is properly cited. Pan African Medical Journal .... vasculaire, associé à une augmentation du nombre et de l'épaisseur des fibres de .... active entre 1 et 6 mois après l'accouchement avec un pic entre 6 et 12 semaines.

  10. Investigation fonctionnelle des complexes enzymatiques mitochondriaux de patients présentant une suspicion de myopathie mitochondriale

    OpenAIRE

    Faundez, Antonio Arturo

    2004-01-01

    Depuis quelques années en Suisse Romande, il n'a pas été possible de poser un diagnostic clair chez 70 à 80 patients sur plus de 200 investigués en raison d'une symptomatologie de fatigabilité et/ou de douleurs musculaires. Un petit nombre d'entre eux présentait des anomalies de laboratoire non spécifiques, mais pouvant être compatibles avec une mitochondriopathie. En collaboration avec le groupe d'étude du Réseau Neuromusculaire Romand, la Division de Recherche Neuromusculaire et la Clinique...

  11. Composition corporelle et caractéristiques biologiques des muscles chez les bovins en croissance et à l'engrais

    OpenAIRE

    Micol, Didier; Robelin, Jacques; Geay, Y

    1993-01-01

    Cet article présente de façon synthétique les connaissances acquises par différentes équipes de recherches sur les lois biologiques de variations de la composition corporelle des bovins et les effets des facteurs zootechniques qui permettent de la modifier (génotype, sexe, stade d’abattage, niveau d’alimentation, nature de la ration et facteurs de croissance). Les caractéristiques du tissu musculaire, déterminantes pour la qualité de la viande, et leurs variations sous l’influence des mêmes f...

  12. Bilateral symmetry of radial pulse in high-level tennis players : implications for the validity of central aortic pulse wave analysis

    OpenAIRE

    Gojanovic, B.

    2010-01-01

    Rapport de synthèse Ce travail de thèse s'articule autour de l'importance de l'évaluation de la fonction vasculaire et des répercussions au niveau central, cardiaque, des perturbations du réseau vasculaire. Les maladies cardiovasculaires sont prédominantes dans notre société et causes de morbidité et mortalité importante. La mesure de la pression artérielle classique reste le moyen le plus utilisé pour suivre la santé des vaisseaux, mais ne reflète pas directement ce qui se passe au niveau...

  13. Faible taux de succes du sevrage tabagique a court et moyen termes au decours d�un infarctus aigu du myocarde dans un service de cardiologie de Dakar au Senegal

    Directory of Open Access Journals (Sweden)

    Alassane Mbaye

    2011-10-01

    Full Text Available e le tabac pendant l�hospitalisation. Apres un suivi de 3 mois, 45% des patients ont repris le tabac, 65% a 6 mois et 85% a 12 mois. CONCLUSION: Le tabagisme est assez frequent chez les patients senegalais presentant un infarctus du myocarde. Le taux de sevrage tabagique a court et moyen termes est faible. Le sevrage tabagique devrait alors constituer un objectif privilegie dans la prevention des maladies cardio-vasculaires.

  14. Contenu de la fréquence de l'E.E.G. en fonction de l'effort physique et mental chez des malades présentant une insuffisance cérébrovasculaire (Communication préliminaire)

    NARCIS (Netherlands)

    Troost, J.; Kamp, A.; Kamphuisen, A.H.C.; Storm van Leeuwen, W.

    Le contenu de la fréquence de l'E.E.G. en fonction de l'effort physique et mental chez des malades présentant une insuffisance cérébro-vasculaire (une communication préalable). La méthode consiste en une analyse spectrale digitale de l'E.E.G., qui est enregistré à l'aide d'un système

  15. Vasculopathie artérielle dans la sclérodermie systémique. Caractéristiques micro- et macrovasculaire de l’angioscanner des artères des membres supérieurs

    NARCIS (Netherlands)

    Emad, Y.; Al-Sherbeni, H.; Ragab, Y.; Abo-El-Youn, I.; El-Shaarawy, Nashwa; Nassar, D.Y.; Fathy, Ahmed; Al-Hanafi, H.; Rasker, Hans

    2015-01-01

    Objectifs Décrire les résultats de l’angioscanner de la vasculopathie artérielle des gros vaisseaux ainsi que des petits et moyens vaisseaux de l’ensemble de l’arbre vasculaire des membres supérieurs chez les patients porteurs d’une sclérodermie systémique (ScS) avec ou sans ulcération digitale. Mé

  16. Research

    African Journals Online (AJOL)

    abp

    1 juin 2012 ... tuberculeuse a été diagnostiquée chez dix patients âgés de 18 à 82 ans. ... Elles touchent surtout les sujets jeunes et un intérêt particulier devrait être ... déjà compliquée d'un accident vasculaire cérébral (AVC) ischémique.

  17. Operational Helicopter Aviation Medicine

    Science.gov (United States)

    1978-12-01

    limited to citizens of the NATO nations. The content of this publication has been reproduced directly from material supplied by AGARD or the authors...work will help him meet and perhaps solve perplexing questions we all face. VA no CONTENTS pope PANEL AND MEETING OFFICERS iU SESSION CHAIRMEN iv...dans un service cardlo- vasculaire . D’une part, par suite d’une situation conflictuelle, aucune ambulance routi~re n’Lstait disponible, d’autre part, la

  18. Implications of Advanced Technologies for Air and Spacecraft Escape

    Science.gov (United States)

    1990-02-01

    Participation in AGARD activities is by invitation only and is normally limited to citizens of the NATO nations. "The content of this publication has been...J.A.Winship, CAF AGARD/’NATO 7, rue Ancelle 92200 Neuilly sur Seine France iv Best Available Copy CONTENTS PREFACE Pg PAM~ AND MEFI1NG OFFICIALS...toldrance cardio- vasculaire et roopirataire ni ia taldrence au:: of Lots vestibulaires does rotations no sont oxcellentes shez lea sojets non entrainda. On

  19. etude epidemiologique de la carie dentaire en milieu scolaire a ...

    African Journals Online (AJOL)

    La carie dentaire est considérée comme le quatrième fléau mondial, après les cancers, les maladies cardio-vasculaires et le sida. Il s'agit d'une ... un problème majeur de santé publique. .... liste des établissements fournie par le Ministère de.

  20. Profil des insuffisants rénaux chroniques diabétiques à l'initiation de l'hémodialyse au service de néphrologie et dialyse de l'hôpital militaire de Rabat, Maroc

    Science.gov (United States)

    El Farouki, Mohamed Reda; Bahadi, Abdelaali; Hamzi, Mohamed Amine; Kabbaj, Driss; Benyahia, Mohammed

    2013-01-01

    Résumé Le diabète constitue une cause fréquente d'insuffisance rénale chronique terminale (IRCT) dans le monde. Ce travail présente une étude clinique rétrospective dont le but est de décrire le profil clinico-biologique des patients diabétiques en IRCT, de le comparer aux patients non-diabétiques au stade d'IRCT, et de suivre l’évolution de leurs abords vasculaires, afin d'en déduire des conclusions sur une prise en charge particulière des patients diabétiques. Les paramètres cliniques et biologiques concernant les patients mis en hémodialyse dans notre formation entre le 01 janvier 2006 et le 31 décembre 2011, ont été recueilli et analysés. Nous avons procédé à l’étude comparative des patients en fonction de l'existence ou non d'une néphropathie diabétique, et nous nous sommes intéressés à l’évolution de leurs abords vasculaires. Il s'agit de 207 patients insuffisants rénaux chroniques, dont 86 diabétiques. Le groupe des patients diabétiques était moins suivi avant la mise en hémodialyse (3,66 mois vs. 6,32 mois), avec une prise beaucoup plus importante d'antihypertenseurs (1,87 vs. 1,14, p<0,001). L’échec des abords vasculaires était plus important chez les patients diabétiques (45% vs. 27%, p=0,006), avec une survie moyenne plus faible de leurs abords vasculaires (509 vs 753 jours, p=0,003). L’étude comparative des taux d'hémoglobine, de parathormone intacte, d'albuminémie et de C-réactive protéine, entre le groupe de patients diabétiques et non diabétiques était non significative. Notre étude soulève le problème du suivi néphrologique chez les diabétiques, pourtant censés être mieux suivis, et son retentissement sur l'avenir de leurs abords vasculaires. PMID:24255730

  1. L'atteinte osseuse dans le sarcome de Kaposi classique et agressif: à propos d'un cas

    Science.gov (United States)

    Sbiyaa, Mouhcine; El Alaoui, Adil; El Bardai, Mohammed; Mezzani, Amine; Lahrach, Kamal; Marzouki, Amine; Boutayeb, Fawzi

    2016-01-01

    Le sarcome de Kaposi classique est une tumeur rare multifocale d'origine des cellules endothéliales vasculaires à caractère évolutif progressif et peu maligne. L'atteinte viscérale dans le sarcome de kaposi est parfois observée chez les patients VIH positif par contre la dissémination tumorale dans les ganglions lymphatiques viscérales dans le SK classique reste très rare. On rapporte un cas rare de sarcome de kaposi classique agressif de la main avec une évolution rapide et destructive. PMID:27347285

  2. SVELTE: Evaluation device of energy expenditure and physical condition for the prevention and treatment of obesity-related diseases through the analysis of a person's physical activities

    OpenAIRE

    Doron, Maeva; BASTIAN, Thomas; MAIRE, Aurelia; PERRIN, Emilie; Oudre, Laurent; OVIGNEUR, Hervé; Gris, Florence; FRANCIS, Anne-Lore; ANTONAKIOS, Michel; Guillemaud, Régis; Villars, Clément; Dugas, Julien; Bourdin, Muriel; Deschamps, Thibault; Bianchi, Pascal

    2013-01-01

    Le niveau quotidien d’activité physique influence les risques de développement des pathologies chroniques les plus fréquentes. Chez l’adulte, un faible niveau d’activité physique et un comportement sédentaire sont associés à une augmentation des risques de maladies cardio-vasculaires (comme l’hypertension artérielle), de diabète de Type 2 et de certains cancers. L’activité physique intervient également dans le contrôle du poids des personnes obèses, et le maintie...

  3. Projet Monica, enquête de population 1984/1985 dans les cantons de Vaud et Fribourg : rapport final sur l'analyse de la plombémie

    OpenAIRE

    Berode, Michèle; Guillemin, Michel; Rickenbach, Martin; Wietlisbach, Vincent

    1986-01-01

    Le dosage du plomb sanguin a été inclus dans l'enquête MONICA (MONItoring of trends and determinants in CArdiovascular disease) sur un échantillon représentatif de la population des cantons de Fribourg et de Vaud. Les résultats sont présentés en trois sections: 1) Distribution de la plombémie en fonction de quelques variables spécifiques: variables socio-démographiques, facteurs de risque classiques des maladies cardio-vasculaires, variables sur certaines habitudes alimentaires; 2) Analyse di...

  4. Protocoles d'anesthésie et de réanimation des mammifères marins : application au grand dauphin (Tursiops truncatus) et à l'otarie de Californie (Zalophus californianus)

    OpenAIRE

    Palmas, Olivier

    2008-01-01

    Les mammifères marins représentés par le grand dauphin (Tursiops truncatus) et l'otarie de Californie (Zalophus californianus) sont la clef de voûte d un parc marin et la contention chimique et physique sont des actes essentiels pour gérer ces animaux au quotidien. En effet, les spécificités anatomiques et physiologiques de ces animaux doivent être connues du praticien, notamment les modifications de l'appareil vasculaire et respiratoire. C'est cette dernière fonction qui demande le plus d'at...

  5. Low-ionization structures in planetary nebulae - I: physical, kinematic and excitation properties

    CERN Document Server

    Akras, Stavros

    2015-01-01

    Though the small-scale, low-ionization knots, filaments and jets (LISs) of planetary nebulae (PNe) are known for ~30yr, some of their observational properties are not well established. In consequence our ability to include them in the wider context of the formation and evolution of PNe is directly affected. Why most structures have lower densities than the PN shells hosting them? Is their intense emission in low-ionization lines the key to their main excitation mechanism? Therefore, if considered altogether, can LISs line ratios, chemical abundances and kinematics enlighten the interplay between the different excitation and formation processes? Here we present a spectroscopic analysis of five PNe that possess LISs confirming that all nebular components have comparable electron temperatures, whereas the electron density is systematically lower in LISs than in the surrounding nebula. Chemical abundances of LISs versus other PN components do not show significant differences as well. By using diagnostic diagrams ...

  6. Fiabilité intra- et inter-examinateurs du dynamomètre MicroFET2 pour la flexion et l'abduction de l'épaule: une étude transversale avec répétition des mesures

    OpenAIRE

    Solier, Auriane; Boichat, Valérie; Mittaz Hager, Anne-Gabrielle

    2016-01-01

    En physiothérapie, l’évaluation de la force musculaire est un élément essentiel du bilan et du suivi du patient. Le testing manuel se révèle subjectif et peu précis pour évaluer une force supérieure à 3. Les dynamomètres manuels sont une alternative pratique et peu coûteuse. Notre objectif est d’évaluer la fiabilité du dynamomètre MicroFET2 pour la mesure de la force isométrique maximale de la flexion et de l’abduction de l’épaule. In der Physiotherapie, ist die Auswertung der Muskelkr...

  7. Fiabilité intra- et inter-examinateur du dynamomètre MicroFET2 pour la flexion et l'extension du genou: une étude transversale avec répétition des mesures

    OpenAIRE

    Indermühle, Caroline; Henguely, Dunja; Mittaz Hager, Anne-Gabrielle

    2016-01-01

    L’évaluation de la force musculaire est un élément essentiel de la prise en charge physiothérapeutique. Le testing manuel se révèle subjectif et peu précis pour quantifier la force lorsqu’elle est élevée. L’objectivité est pourtant nécessaire et dépend de la qualité des mesures. Les dynamomètres manuels, tels que le microFET2 ont été développés afin de démontrer l’efficacité des traitements de manière objective. Notre objectif est donc de conduire une étude, avec un protocole standardisé...

  8. Fiabilité intra- et inter-examinateur du dynamomètre microFET2 pour mesurer la force isométrique maximale du membre supérieur: protocole pour une étude diagnostique de type transversal

    OpenAIRE

    Thirion, Amélie; Racine, Isabelle; Mittaz Hager, Anne-Gabrielle

    2015-01-01

    L’évaluation de la force musculaire est un élément essentiel de la prise en charge physiothérapeutique. Il est primordial et pertinent d’évaluer cette force avec précision pour objectiver la présence d'un déficit, effectuer des comparaisons ou encore pour suivre la progression d’un traitement. Le testing manuel est la méthode la plus communément utilisée. Elle se révèle toutefois subjective et peu précise pour quantifier la force lorsqu’elle est élevée. L’objectivité est cependant nécess...

  9. The black stuff and Konstantin Nikolaevich Tretiakoff.

    Science.gov (United States)

    Lees, Andrew J; Selikhova, Marianna; Andrade, Luiz Augusto; Duyckaerts, Charles

    2008-04-30

    Konstantin Tretiakoff's doctoral dissertation "Contribution a l'Etude de L'Anatomie pathologique du Locus Niger de Soemmering avec quelques déductions relatives à la pathogénie des troubles du tonus musculaire et De La Maladie de Parkinson" (A Study of the Pathological anatomy of the locus niger of Soemerring and its relevance to the pathogenesis of changes in muscular tone in Parkinson's disease) published in 1919 earned him a silver medal awarded by the University of Paris but failed to gain him the recognition its importance deserved. Despite belated acknowledgment of the importance of his findings Tretiakoff received little acclaim during his life and there have been no biographical accounts written in English or French. Fifty years after his death it seems appropriate to relate some aspects of his interesting peripatetic life and recognize the continuing relevance of his pioneering research on "the black stuff" to our understanding of Parkinson's disease.

  10. YOGA CLUB

    CERN Multimedia

    CLUB DE YOGA

    2010-01-01

    DÉBUT DES COURS   mercredi 1er septembre 2010   (Yoga, Sophrologie, Tai Chi, Zen) Liste des cours pour le semestre allant du 1 er septembre 2010 au 31 janvier 2011. New: one course will be held in English Viniyoga (progressive and adaptable yoga, emphasis on breathing) Courses held in English Teacher: Marta Csatari 1 course per week Tuesday 12h15 – 13h30 Viniyoga (yoga progressif et adapté, appui sur la respiration) Professeur : Magali Roussel 2 cours hebdomadaires Lundi       11h15 – 12h30                12h30 – 13h45 (débutants) Hatha Yoga et yoga chinois (tonification musculaire) Professeur : Marie-Claude Pihet 2 cours hebdomadaires Mardi      17h30 – 18h30 &nb...

  11. YOGA CLUB

    CERN Multimedia

    Yoga Club

    2010-01-01

    NOUVELLES INSCRIPTIONS Liste des cours pour le semestre allant du 1er février au 30 juin 2010. Viniyoga (yoga progressif et adapté, appui sur la respiration) Professeur : Danielle Fahy 3 cours hebdomadaires   Lundi 11 h 15 – 12 h 30   12 h 30 – 13 h 45 (débutants) Mardi 12 h 15 – 13 h 30   Hatha Yoga et yoga chinois (tonification musculaire) Professeur : Marie-Claude Pihet 2 cours hebdomadaires   Mardi 17 h 30 – 18 h 30   18 h 30 – 19 h 30 (avancés)   Hatha Yoga et stretching Professeur : Michel Cohen 6 cours hebdomadaires   Mercredi 11 h 30 –...

  12. YOGA CLUB

    CERN Multimedia

    Yoga club

    2010-01-01

     NOUVELLES INSCRIPTIONS Liste des cours pour le semestre allant du 1 février au 30 juin 2010.  – Viniyoga (yoga progressif et adapté, appui sur la respiration) Professeur : Danielle Fahy 3 cours hebdomadaires : Lundi     11h15 – 12h30              12h30 – 13h45 (débutants) Mardi     12h15 – 13h30 – Hatha yoga et yoga chinois (tonification musculaire) Note : début de ce cours le 8 septembre 2009 Professeur : Marie-Claude Pihet 2 cours hebdomadaires : Mardi     17h30 – 18h30               18h30 – 19h30 (avancés) – Hath...

  13. Une Nouvelle Orientation Psychophysique dans la Pédagogie Théâtrale Contemporaine

    Directory of Open Access Journals (Sweden)

    Vezio Ruggieri

    2015-09-01

    Full Text Available Cet article a pour but de présenter comment les apports du modèle psychophysiologique bio-existentialiste élaboré par Vezio Ruggieri et ses collaborateurs peuvent jeter une lumière nouvelle sur les processus sous-jacents le jeu de l’acteur tels que la présence scénique, le processus d’identification avec un personnage et le complexe mécanisme de la prosodie. Cet encadrement théorique, qui voit le rapport corps-esprit dans une relation circulaire, éclairera le lecteur sur les bases physiologiques de la perception et de l’imagination ainsi que sur le rôle fondamental que la structure musculaire joue dans la construction de ces phénomènes.

  14. Outcome analysis of retrograde nailing and less invasive stabilization system in distal femoral fractures: A retrospective analysis

    Directory of Open Access Journals (Sweden)

    Christian Hierholzer

    2011-01-01

    Full Text Available Background: Two major therapeutic principles can be employed for the treatment of distal femoral fractures: retrograde intramedullary (IM nailing (RN or less invasive stabilization on system (LISS. Both operative stabilizing systems follow the principle of biological osteosynthesis. IM nailing protects the soft-tissue envelope due to its minimally invasive approach and closed reduction techniques better than distal femoral locked plating. The purpose of this study was to evaluate and compare outcome of distal femur fracture stabilization using RN or LISS techniques. Materials and Methods: In a retrospective study from 2003 to 2008, we analyzed 115 patients with distal femur fracture who had been treated by retrograde IM nailing (59 patients or LISS plating (56 patients. In the two cohort groups, mean age was 54 years (17-89 years. Mechanism of injury was high energy impact in 57% (53% RN, 67% LISS and low-energy injury in 43% (47% RN, 33% LISS, respectively. Fractures were classified according to AO classification: there were 52 type A fractures (RN 31, LISS 21 and 63 type C fractures (RN 28, LISS 35; 32% (RN and 56% (LISS were open and 68% (RN and 44% (LISS were closed fractures, respectively. Functional and radiological outcome was assessed. Results: Clinical and radiographic evaluation demonstrated osseous healing within 6 months following RN and following LISS plating in over 90% of patients. However, no statistically significant differences were found for the parameters time to osseous healing, rate of nonunion, and postoperative complications. The following complications were treated: hematoma formation (one patient RN and three patients LISS, superficial infection (one patient RN and three patients LISS, deep infection (2 patients LISS. Additional secondary bone grafting for successful healing 3 months after the primary operation was required in four patients in the RN (7% of patients and six in the LISS group (10% of patients

  15. De rol van led-licht en fytoplasma's in de broeierij (over onderzoek van Henk Gude tijdens de Kennisdag)

    NARCIS (Netherlands)

    Neefjes, H.; Gude, H.

    2010-01-01

    Led-licht is een handig stuurmiddel in de broeierij. Fytoplasma's zijn juist zeer ongewenst. Tijdens de Kennisdag van PPO in Lisse op vrijdag 12 februari 2010 werd uitleg gegeven over deze en andere onderwerpen

  16. 1 m digital bathymetric contours from NOAA charts as organized for the Long Island Sound Study Geographic Information System (LISSGIS) library (LISBATHY.SHP)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Long Island Sound Study (LISS) compiled data from a number of different sources, integrated new data, and assembled a comprehensive spatial database for areas of...

  17. 1231-IJBCS-Article-Aklesso Mouzou

    African Journals Online (AJOL)

    KODJIO NORBERT

    En outre, cette solution semi-éthanolique aurait une action similaire (diminution de la ... Mots clés: Trema guineensis; muscles lisses; canaux calciques. ..... acetylcholine on longitudinal muscle of ... Regulation of smooth muscle calcium ...

  18. Revertant mosaicism in human genetic disorders

    NARCIS (Netherlands)

    Jonkman, MF

    1999-01-01

    Somatic reversion of inherited mutations is known for many years in plant breeding, however it was recognized only recently in humans. The concept of revertant mosaicism is important in medical genetics. (C) 1999 Wiley-Liss, Inc.

  19. 1 m digital bathymetric contours from NOAA charts as organized for the Long Island Sound Study Geographic Information System (LISSGIS) library (LISBATHY.SHP)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Long Island Sound Study (LISS) compiled data from a number of different sources, integrated new data, and assembled a comprehensive spatial database for areas...

  20. Balancing the big stuff: finding happiness in work, family, and life

    National Research Council Canada - National Science Library

    Liss, Miriam; Schiffrin, Holly H

    2014-01-01

    .... Liss and Schiffrin discuss the ways in which we define "having it all" and how we can obtain it for ourselves through a better evaluation of what we want from ourselves, our families, our jobs, and each other...

  1. A comparative study of less invasive stabilization system and titanium elastic nailing for subtrochanteric femur fractures in older children.

    Science.gov (United States)

    Sun, Liao-Jun; Wu, Zhi-Peng; Dai, Cheng-Qian; Guo, Xiao-Shan; Chen, Hua

    2015-03-01

    The objective of this study was to compare prospectively the complications and the radiographic and clinical outcomes of reverse less invasive stabilization system (LISS) and titanium elastic nailing (TEN) for the treatment of subtrochanteric femur fractures in older children. From April 2004 to February 2012, 52 children aged from 10 to 15 years old with subtrochanteric fractures were included in this study. 26 patients were treated with reverse LISS (LISS group) and 26 children treated with titanium elastic nails (TEN group) respectively. Perioperative care was standardized. Surgical time, blood loss, length of hospitalization, hospital costs, fracture union time, full weight-bearing time and complications were analyzed. The radiologic results as well as hip functional outcomes were evaluated. The average follow-up time of LISS group was 36.5±9.3 months and TEN group was 40.2±10.6 months. No significant difference between these two groups was found in union time, full weight-bearing time and average length of hospitalization. However, the patients of LISS group had longer operation time (60.0±10.6 min vs. 40.5±7.4 min, psubtrochanteric femur fractures in older children was associated with better function scores and a lower overall complication rate when compared with reverse LISS.

  2. Red cell antibodies and low ionic strength: a study with enzyme-linked antiglobulin test.

    Science.gov (United States)

    Leikola, J; Perkins, H A

    1980-01-01

    Alloantibody uptake on red blood cells was quantified with an accurate and reproducible enzyme-linked antiglobulin test. The uptake of anti-D, anti-Fy2 and anti-JK3 was markedly accelerated by low ionic strength salt solution (LISS) with a final ionic strength of 0.05 M. Near maximum uptake occurred within ten minutes at room temperature which corresponded to 60 minutes in saline at 37 C. Papain treatment of red blood cells increased the amount of anti-D bound, and there was no difference whether or not the papain-treated cells were suspended in LISS. In contrast, the uptake of IgG anti-A and anti-Leb was not accelerated by LISS, nor did LISS increase the rate of binding of antiblogulin to IgG antibody-coated red blood cells. We suggest this may be explained by the fact that the ABH and Lewis antigens (as well as bound IgG antibodies) extend beyond the "ionic cloud" surrounding the red blood cell. Antibody binding in the presence of albumin was approximately the same as in saline; but if the albumin was first dialyzed against LISS, the reaction was markedly accelerated and the final antibody uptake somewhat higher than in LISS alone.

  3. Anabolic Effect of Exercise Training in People with End-Stage Renal Disease on Hemodialysis: A Systematic Review with Meta-analysis.

    Science.gov (United States)

    Sawant, Anuradha; House, Andrew A; Overend, Tom J

    2014-01-01

    Objectif : Cette critique systématique visait principalement à évaluer l'effet anabolique de l'exercice chez des adultes vivant avec une insuffisance rénale chronique au stade ultime et suivant des traitements d'hémodialyse (HD). Les objectifs secondaires consistaient à évaluer l'influence des caractéristiques des participants et des paramètres de l'exercice sur les changements de la taille des muscles. Méthodes : On a effectué des recherches dans des bases de données électroniques (Cochrane, CINAHL, EMBASE, PEDro, PubMed et SCOPUS) depuis leur création jusqu'en novembre 2012. On a inclus des essais cliniques randomisés publiés en anglais et portant sur des adultes en HD suivant un programme d'exercice au cours duquel on a mesuré la masse musculaire comme résultat. Deux examinateurs agissant indépendamment ont choisi les études, extrait des données et évalué le risque de biais dans les études incluses. Les résultats ont ensuite été combinés par méta-analyse. On a déterminé l'effet de l'exercice au moyen d'une différence moyenne normalisée (DMN) exprimée par la mesure g de Hedges, calculé au moyen d'un modèle à effet aléatoire. Résultats : Sept DMV extraites de cinq études ont été incluses pour analyse finale. On a utilisé la musculation dans toutes les études, dont une a utilisé l'entraînement aérobie et mixte (musculation et aérobie) avec deux sous-groupes de participants. L'effet global de l'exercice sur la masse musculaire a été statistiquement significatif (DMN: 0,272; IC à 95%, 0,020 à 0,525). Conclusion : Nos résultats confirment un effet modeste mais significatif de l'exercice de renforcement comme intervention anabolique visant à accroître la masse musculaire. Il faudrait inclure l'exercice dans la prise en charge de routine des personnes en HD d'entretien. Même si les résultats courants indiquent qu'une personne sur neuf en HD est susceptible de bénéficier de l'exercice, une recherche plus

  4. An Exploratory Study to Determine the Relationship between Cervical Dysfunction and Perimenstrual Migraines.

    Science.gov (United States)

    Horwitz, Simone; Stewart, Aimee

    2015-01-01

    Objectif : Cette étude visait à déterminer s'il y a un lien entre la dysfonction cervicale et les migraines périmenstruelles. Méthodes : On a comparé 40 femmes souffrant de migraines périmenstruelles à 46 témoins. On a réuni de l'information sur l'âge des participantes et les perceptions de la douleur et de la raideur dans le cou. L'examen médical à l'insu de la région cervicale a consisté à évaluer la posture, l'amplitude du mouvement, la force musculaire, la longueur des muscles, le point de déclenchement, la mobilité neurale et le mouvement de l'articulation cervicale segmentaire. Résultats : Les patientes souffrant de migraines avaient une perception accrue de la douleur et de la raideur dans le cou (pdroits (p=0,045); ressentaient plus de douleur à l'étirement musculaire au niveau des deux muscles élévateurs de la scapula, des deux trapèzes, du sternocléidomastoïdien gauche et des deux occipitaux (p=0,013); une élévation des points de déclenchement des deux côtés dans le trapèze gauche (p=0,021), le trapèze droit (p=0,023), le sternocléidomastoïdien gauche (p=0,0004) et le sternocléidomastoïdien droit (p=0,021); une réduction de la mobilité neurale avec latence du coude des deux côtés (p=0,043); douleur plus grande au niveau C4-C6 (p=0,045) et une raideur accrue de la colonne cervicale au niveau C5-C7 (p=0,023). Il n'y avait pas de différences aux niveaux de la posture et de la force musculaire. La diminution de la longueur des muscles accroissait le risque de migraine périmenstruelle d'un facteur de 2,4 à 6,7; réduisait la mobilité neurale d'un facteur de 5,8-10,7; augmentait la raideur au niveau C7 d'un facteur de 17,0. Conclusion : Les résultats indiquent qu'il faudrait étudier plus à fond l'existence d'un lien entre le dysfonctionnement cervical et les maux de tête périmenstruels.

  5. [Medical management of cervical arterial dissections].

    Science.gov (United States)

    Vuillier, F; Tatu, L; Moulin, T

    2002-12-01

    Medical management of cervical arterial dissections is not standardized and has not been the subject of randomized trials. Management is mainly based on the presumed pathophysiology of secondary cerebral infarcts associated with dissections and the individual experience of each treating team. First, a review of the literature regarding medical management of acute and chronic dissections is presented. Then, results from a national study sponsored by the Société Française Neuro-Vasculaire and the Société Française de Neuro-Radiologie evaluating the medical management of this pathology in French neuro-vascular centers will be presented. These data will be useful to generate practical management recommendations and establish guidelines for further studies.

  6. SYNDROME CORONAIRE AIGU

    OpenAIRE

    BENGRINE, Souad

    2013-01-01

    Les maladies cardiovasculaires constituent un véritable défi à l'humanité, il n'est pas déraisonnable de parler de pandémie. L'incidence des maladies cardio-vasculaires, en particulier les cardiopathies ischémiques, tend à augmenter dans les pays en voie de développement. Réduire les risques et promouvoir une vie saine dans les régions pauvres, ces FDR sont à l'origine d'une charge croissante de morbidité grave et de mortalité prématurée. Ainsi que l'a souligné le directeur ...

  7. Les maladies de coeur dans les recueils de recettes médicales et pharmaceutiques de la fin du Moyen Âge

    OpenAIRE

    Lorcin, Marie-Thérèse

    2014-01-01

    Les maladies cardio-vasculaires arrivent en tête des causes de décès dans l'Occident actuel, devançant le cancer qui inspire pourtant une terreur plus grande. C'est le privilège des populations bien nourries mais usées par le tabac, l'alcool, le stress, et surtout exposées, par l'allongement constant de la durée de la vie, à ces affections dont la fréquence croît avec l'âge. Les prouesses de la chirurgie cardiaque ne suffisent pas à renverser la tendance, puisque les maladies cardiovasculaire...

  8. Vivre à domicile, deux ans après un AVC : Etude auprès des patients et des aidants du Luxembourg.

    OpenAIRE

    Baumann, Michèle

    2012-01-01

    Au Luxembourg, une recherche pluridisciplinaire a été réalisée auprès de 797 personnes victimes d’un accident vasculaire cérébral (AVC). Une enquête nationale a été menée comportant un volet épidémiologique effectué par le CRP-Santé, qui a rassemblé des données médico-administratives et des données cliniques issues des dossiers d’hospitalisation, et un volet de sociologie médicale par l’Université qui a interrogé 94 patients vivant au domicile, deux après la survenue de l’AVC, et leurs 62 aid...

  9. Corrélations entre marqueurs de métabolisme phosphocalcique et histologie rénale chez les patients allogreffés rénaux

    OpenAIRE

    Berchtold, Lena

    2016-01-01

    Cette étude rétrospective monocentrique incluant 129 patients greffés rénaux, teste l’hypothèse que les variables du bilan phosphocalcique ainsi qu’un test de la propension à calcifier (T50) pourraient prédire les lésions histologiques (fibrose interstitielle ; inflammation ; atteinte vasculaire) et l’évolution de la fonction rénale à deux ans. Les résultats montrent que la PTH et la vitamine D corrèlent de façon intéressante avec la fibrose rénale (PTH : r=0.29: p=0.0011 ; vitamine D r=-0.23...

  10. Le sujet âgé en hémodialyse chronique: expérience d'un centre hospitalier marocain

    OpenAIRE

    Karimi, Ilham; Benabdellah, Nawal; Bentata, Yassamine; Haddiya, Intissar

    2013-01-01

    De plus en plus de patients âgés sont pris en charge en hémodialyse chronique. L'augmentation de l'incidence de la maladie rénale chronique, du diabète et l'amélioration de la survie cardio-vasculaire expliquent en grande partie ce constat. Les conséquences de la prise en charge de ces patients âgés en en hémodialyse chronique sont multiples. Elles sont dominées par les comorbidités et les troubles d'autonomie. Le but de notre étude est de décrire le profil épidémiologique et clinique des pat...

  11. Le syndrome d'Othello: un cas observé à Ouagadougou

    OpenAIRE

    Kaboré, Bawindsongré Jean; Napon, Christian

    2013-01-01

    Les auteurs rapportent le premier cas de délire de jalousie encore décrit sous l'acronyme de syndrome d'Othello, à Ouagadougou. Il s'est agit d'un patient qui au décours d'un accident vasculaire cérébral ischémique constitué, a développé un délire de jalousie. Une revue de la littérature permet de comprendre que l'affection, rarement rapportée est de plus en plus décrite au décours de maladies neurologiques aigues ou chroniques, et que le lobe frontal joue vraisemblablement un rôle majeur....

  12. Le syndrome d'Othello: un cas observé à Ouagadougou

    Science.gov (United States)

    Kaboré, Bawindsongré Jean; Napon, Christian

    2013-01-01

    Les auteurs rapportent le premier cas de délire de jalousie encore décrit sous l'acronyme de syndrome d'Othello, à Ouagadougou. Il s'est agit d'un patient qui au décours d'un accident vasculaire cérébral ischémique constitué, a développé un délire de jalousie. Une revue de la littérature permet de comprendre que l'affection, rarement rapportée est de plus en plus décrite au décours de maladies neurologiques aigues ou chroniques, et que le lobe frontal joue vraisemblablement un rôle majeur. PMID:24570777

  13. SYNDROME CORONAIRE AIGU

    OpenAIRE

    BENGRINE, Souad

    2013-01-01

    Les maladies cardiovasculaires constituent un véritable défi à l'humanité, il n'est pas déraisonnable de parler de pandémie. L'incidence des maladies cardio-vasculaires, en particulier les cardiopathies ischémiques, tend à augmenter dans les pays en voie de développement. Réduire les risques et promouvoir une vie saine dans les régions pauvres, ces FDR sont à l'origine d'une charge croissante de morbidité grave et de mortalité prématurée. Ainsi que l'a souligné le directeur ...

  14. Comparative biomechanical study of reversed less invasive stabilization system and proximal femoral nail antirotation for unstable intertrochanteric fractures

    Institute of Scientific and Technical Information of China (English)

    Chen Ying; Liu Shouyao; Lin Peng; Wang Yunting; Wang Jinhui; Tao Jianfeng; Cai Rongrong

    2014-01-01

    Objective Unstable intertrochanteric fractures (ITFs) are mostly treated by proximal femoral nail antirotation (PFNA),Inter-Tan,Asian Hip,and other new internal fixation devices.But for complex unstable fractures,such as crushed lateral wall of the greater trochanter,the loss of fixation point on lateral wall slightly reduces the fixing effect.This study aimed to compare the biomechanical strengths between reversed less invasive stabilization system (LISS) and PFNA for treatment of unstable ITFs.Methods Forty synthetic femurs were used to simulate unstable ITFs in vitro and were fixed using the reversed LISS or PFNA.These fractures were divided into two groups depending on whether the lateral wall of the greater trochanter is intact or not (AO classification:31-A2.3 and 31-A3.3,respectively).The load-displacement of femur,stiffness,ultimate load,and cyclic fatigue resistance were detected using an incremental load test and a dynamic fatigue test through an MTS 858 test system.Results For both 31-A2.3 and 31-A3.3,the vertical sinking displacement (VSD) of the femoral head under 500 N load was insignificantly smaller after treatment with reversed LISS than with PFNA,and when the displacement was 5 mm,the femoral head bore insignificantly greater load.The fixation with reversed LISS resulted in greater axial stiffness of the femur but smaller ultimate load.During the same cycle in the dynamic fatigue test,the VSD was insignificantly smaller with the fixation of reversed LISS.Conclusion Reversed LISS and PFNA have similar biomechanical strength for unstable ITFs.This conclusion should be supported by additional large-size research on basic biomechanics and clinical application.This is the first comparative biomechanical study comparing reversed LISS and PFNA for unstable ITFs.

  15. L'accident ischémique cérébral chez le sujet jeune: à propos de 6 cas

    Science.gov (United States)

    Khammassi, Naziha; Sassi, Yosra Ben; Aloui, Asma; Kort, Youssef; Abdelhedi, Haykel; Cherif, Ouahida

    2015-01-01

    Les accidents ischémiques cérébraux (AIC) du sujet jeune se caractérisent par une panoplie d’étiologies différentes de celles des accidents vasculaires cérébraux (AVC) du sujet âgé d'où l'intérêt de bien creuser devant une telle atteinte à la recherche surtout d'une thrombophilie ou d'une cardiopathie emboligène. Cependant, il ne faut pas négliger une exposition de plus en plus accrue du sujet jeune à des facteurs de risque cardio-vasculaires tel le tabagisme qui accélère le processus d'athérosclérose, étiologie principale d'AVC tout âge confondu. Nous avons rétrospectivement collecté les données de six patients âgés de moins de 45 ans qui ont été hospitalisés dans notre service pour un AIC. La moyenne d’âge était de 35,3 et les hommes représentaient 16% de notre série. L'enquête étiologique a conclu à un syndrome des anticorps anti-phospholipides secondaire à un syndrome de Gougerot Sjögren chez l'un des patients, un déficit en protéine S chez deux patients et un syndrome de Sneddon chez un autre. Les causes d'AIC n'ont pas été identifiées dans les deux autres cas. Un traitement à base d'anti-vitamines K ou d'antiagrégants plaquettaires a été instauré en cas d’étiologie révélée. PMID:26889323

  16. A Woman With Marfan Syndrome in Pregnancy: Managing High Vascular Risk With Multidisciplinary Care.

    Science.gov (United States)

    Naud, Kentia; Horne, Gabrielle; Van den Hof, Michiel

    2015-08-01

    Contexte : Bien que les femmes qui présentent des troubles affectant les tissus conjonctifs soient exposées à des risques de complications cardiovasculaires pendant la grossesse, nous ne disposons d’aucune ligne directrice en ce qui concerne les femmes enceintes dont le diamètre de l’anneau aortique est supérieur à 45 mm ou qui connaissent un élargissement rapide de l’aorte. Nous décrivons les facteurs significatifs sur le plan pratique dans le cadre de la prise en charge de la grossesse et de l’accouchement chez une femme atteinte du syndrome de Marfan.  Cas : Une femme enceinte atteinte du syndrome de Marfan nous a consultés pour obtenir des soins tertiaires à 26 semaines de gestation. La dilatation rapide de l’aorte a mené à la décision de procéder à un accouchement préterme (lequel a donné lieu à une bonne issue néonatale). Le recours à une approche multidisciplinaire a contribué à l’optimisation du monitorage et de la chronologie de l’accouchement (et à la réparation subséquente de l’aorte), en plus de permettre la planification de la prise en charge d’une potentielle catastrophe vasculaire.  Conclusion : Dans le cas des femmes enceintes qui sont atteintes du syndrome de Marfan, l’obtention d’issues maternelles et néonatales optimales dépend de la mise en œuvre d’un effort d’équipe grandement attentif et coordonné (y compris celle d’une planification méticuleuse de la prise en charge d’une potentielle catastrophe vasculaire).

  17. Utility of space technology for restoration of prime componant of earth ecosystem to the benefit of littoral habitations:a case study from a developing nation

    Science.gov (United States)

    Perni, Venkateswarlu

    The Ramsar site, Kolleru wetland ecosystem, in Andhra Pradesh, India, has been evaluated for its habitat using the geomatics technology. Wetlands are of considerable economic importance in view of the biotic diversity and in to the preferred habitat for a variety of resident and migratory birds. The boundary of the lake is derived from the topomaps of 1:25K and the Joint survey records of Forest and Revenue Departments. There location of the boundary is not possible due to conventional techniques, because of the inaccessibility of the areas. The extent of ponds to be demolished is ascertained and the boundary is relocated within permissible limits. The habitat conditions prior to demolition (Feb'2006) and post demolition of fishponds is evaluated using IRS LISS II 1988,LISS III + PAN 1996, IRS LISS III + PAN 2002, IRS LISS IV 2004, IRS LISS III +PAN 2006, Cartosat 2006 data. The Image restoration for all data is done using various Image Processing Techniques. Expert classifiers, NDWI, PCA, and filtering Techniques are used to delineate the Land use / Land cover Classes and the boundaries of fish ponds. The periodic data revealed a highly degraded state of the Kolleru Lake clearly indicating that about 54

  18. Early rehabilitation following less invasive surgical stabilisation plate fixation for distal femoral fractures.

    Science.gov (United States)

    Smith, T O; Hedges, C; MacNair, R; Schankat, K

    2009-06-01

    The less invasive surgical stabilisation (LISS) plate fixation method is an orthopaedic procedure for the fixation of distal femoral fractures. Early physiotherapy treatments of motion and mobilisation have been advocated following this procedure. This article critically appraises the evidence base assessing the early rehabilitation of patients following LISS fixation for distal femoral fractures. A review of EMBASE, Medline, CINAHL and AMED, and a hand search were undertaken. Two independent reviewers identified all eligible articles. Two reviewers extracted the data, which were verified by a third reviewer. All included articles were critically appraised by two independent reviewers using the Critical Appraisal Skills Programme tool. Seventeen case series assessing 508 patients with 535 fractures were reviewed. No clinical trials comparing physiotherapy programmes were identified. The review identified that following LISS fixation for distal femoral fractures, patients begin range-of-motion exercises immediately and are initially required to restrict weight-bearing following surgery. It remains unclear whether casts, braces or immobilisation aids are applied during the initial postoperative period. The efficacy of different physiotherapy protocols following LISS fixation for distal femoral fractures remains unclear. Further well-designed randomised controlled trials are required to compare different postoperative physiotherapy rehabilitation programmes for patients following LISS fixation of distal femoral fractures in order to determine the optimal postoperative management for this complex patient group.

  19. Safety Training: Sensibilisation aux gestes et postures de travail

    CERN Multimedia

    Laetitia Laddada

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. Nous vous proposons un nouveau cours de sécurité lié aux manutentions manuelles (durée 1 jour) : Sensibilisation aux gestes et postures de travail. Si vous êtes amené à manipuler régulièrement des charges lourdes ou volumineuses, cette formation peut vous aider à prévenir les lésions musculaires ou dorsales. A l'issue de cette formation, vous serez capable d'adopter et d'appliquer les principes de base de sécurité physique et d'économie d'efforts dans les manipulations...

  20. Safety Training: Sensibilisation aux gestes et postures de travail

    CERN Multimedia

    Laetitia Laddada

    2004-01-01

    Nous vous proposons un nouveau cours de sécurité lié aux manutentions manuelles (durée 1 jour) : Sensibilisation aux gestes et postures de travail. Si vous êtes amené à manipuler régulièrement des charges lourdes ou volumineuses, cette formation peut vous aider à prévenir les lésions musculaires ou dorsales. A l'issue de cette formation, vous serez capable d'adopter et d'appliquer les principes de base de sécurité physique et d'économie d'efforts dans les manipulations d'objets. Les cours sont pris en charge par la Commission de Sécurité. L'inscription EDH est obligatoire. Pour plus d'information, veuillez consulter les pages Formation & Développement (Groupe Sécurité). Formation & Développement (Groupe Sécurité) FORMATION EN SECURITE SAFETY TRAINING Laetitia Laddada 73811 - 79236 safety.training@cern.ch

  1. Yoga Club

    CERN Document Server

    Yoga Club

    2011-01-01

    DÉBUT DES COURS mardi 1er février 2011 (Yoga, Sophrologie, Tai Chi, Zen) Liste des cours pour le semestre allant du 1 er février 2011 au 30 juin 2011.   Viniyoga (progressive and adaptable yoga, emphasis on breathing)  Courses held in English Teacher : Marta Csatari 1 course per week Tuesday 12h15 – 13h30 Yoga d’inspiration Viniyoga et Thibétaine Professeur : Danielle FAHY 2 cours hebdomadaires Lundi 11h15 – 12h30          12h30 – 13h45 Hatha Yoga et yoga chinois (tonification musculaire) Professeur : Marie-Claude Pihet 2 cours hebdomadaires Mardi 17h30 – 18h30            18h30 – 19h30 (avancés) Hatha Yoga et stretching Professeur : Michel Cohen 6 cours hebdomadaires Mercredi 11h30 &...

  2. Yoga Club

    CERN Document Server

    Yoga Club

    2011-01-01

    DÉBUT DES COURS mardi 1er février 2011 (Yoga, Sophrologie, Tai Chi, Zen)   Liste des cours pour le semestre allant du 1 er février 2011 au 30 juin 2011.   Viniyoga (progressive and adaptable yoga, emphasis on breathing)  Courses held in English Teacher : Marta Csatari 1 course per week Tuesday 12h15 – 13h30 Yoga d’inspiration Viniyoga et Thibétaine Professeur : Danielle FAHY 2 cours hebdomadaires Lundi 11h15 – 12h30           12h30 – 13h45 Hatha Yoga et yoga chinois (tonification musculaire) Professeur : Marie-Claude Pihet 2 cours hebdomadaires Mardi 17h30 – 18h30            18h30 – 19h30 (avancés) Hatha Yoga et stretching Professeur : Michel Cohen 6 cours hebdomadai...

  3. Yoga Club

    CERN Multimedia

    Yoga Club

    2011-01-01

    YOGA CLUB – REPRISE DES COURS (Yoga, Sophrologie, Tai Chi, Zen) Liste des cours pour le semestre allant du 5 septembre 2011 au 31 janvier 2012. YOGA d'inspiration Viniyoga et Thibétaine Professeur : Danielle Fahy 3 cours hebdomadaires Lundi  11h15 – 12h30           12h30 – 13h45 (débutants) Mardi  12h15 – 13h30 Viniyoga (progressive and adaptable yoga, emphasis on breathing) Courses held in English Teacher: Beatriz Recio Palomero 1 course per week Tuesday  12h15 – 13h30 Hatha Yoga et yoga chinois (tonification musculaire) Professeur : Marie-Claude Pihet 2 cours hebdomadaires Mardi  17h30 – 18h30           18h30 – 19h30 (avancés) Hatha Yoga et stretching Professeur : Michel Cohen 6 cours h...

  4. Early results of reverse less invasive stabilization system plating in treating elderly intertrochanteric fractures: a prospective study compared to proximal femoral nail

    Institute of Scientific and Technical Information of China (English)

    YAO Chen; ZHANG Chang-qing; JIN Dong-xu; CHEN Yun-feng

    2011-01-01

    Background Intertrochanteric femur fracture is common in elderly population. Though multiple treatment options are available, the choice of implant remains controversial. The reverse less invasive stabilization system (LISS) plating was introduced for treatment of a patient with ipsilateral intertrochanteric and midshaft femoral fractures. The aim of this research was to compare such technique to intramedullary nailing (proximal femoral nail, PFN) for intertrochanteric fractures.Methods Fifty-six patients with an age of at least sixty-five years and an AO/OTA type-A1 or A2 fractures were included and divided into LISS and PFN treatment group. Background parameters, fracture and surgery details were documented. Follow-up time was at least 12 months. Radiology, complication, Harris Hip Score and Rapid Disability Rating Score (RDRS) were recorded to evaluate fixation status and hip function for each patient during follow-up.Results There was no significant difference between the two groups in surgical time ((48.0±8.6) minutes, vs.(51.8±10.8) minutes, P=0.3836) and intraoperative blood loss ((149.1±45.1) ml vs. (176.4±25.4) ml, P=0.0712). The LISS group had less postoperative haemoglobin (Hb) reduction ((10.2±4.5) g/L Hb, vs. (15.1~5.9) g/L Hb, P=0.0475). There was no complication observed in PFN group. All 31A1 type fracture in LISS group showed 100% maintenance of reduction. One nonunion with locking screw breakage and 2 varus union were found in the LISS group. Postoperative hip function was similar between the two groups.Conclusions Though reverse LISS plating may not be recommended as a routine fixation method for elderly unstable intertrochanteric fractures compared to PFN, it may possibly be reserved for rapid fixation and damage control in polytrauma patients and ORIF of subtrochanteric and reverse oblique intertrochanteric fractures.

  5. Unusual cause of sudden cardiac death : Basophilic degeneration of coronary arteries

    NARCIS (Netherlands)

    Jessurun, GAJ; Tio, RA; Ribbert, LSM; Willemse, F; Boonstra, PW; Crijns, HJGM

    1996-01-01

    Basophilic or mucoid degeneration of the intima in the coronary arteries is an extremely rare cause of premature atherosclerosis. An unusual case of fatal basophilic degeneration of the coronary arteries 142 days after delivery is reported. (C) 1996 Wiley-Liss, Inc.

  6. Environmental and Health Effects Review for Obscurant Fog Oil

    Science.gov (United States)

    1993-09-01

    clothing) can break down the protective defences of the skin barrier, causing inflammation, acanthosis, and eczema (Liss-Suter et al. 1978a; Smith et...34Pulmonary Pathology from Inhalation of a Complex Mineral Oil Mist in Dogs , Rats, Mice and Gerbils." Amer. Ind. Hyg. Assoc. J. 39:393-399. Sullivan, J. D

  7. Cellular Effects of Endotoxin in Vitro: Mobility of Endotoxin in the Plasma Membrane of Hepatocytes and Neuroblastoma Cells

    Science.gov (United States)

    1985-01-01

    initiates ain.otoxin eqxpocar In the pteet work. we have celular perturbations. remains to be determined. I In vivo stdahawe shown that the liver is an...1977) Scismos 195. 307-309 tomn at the Celular LAve (Majde. JA.. ad.). Mp 81-95. 30 SdchminW. J., SebchaW. Y- Casacasas. P. Wminsa Alan I. Liss. New

  8. Baseline Tests of the Electra Van Model 1000 Electric Vehicle.

    Science.gov (United States)

    1980-07-01

    Argonne National I- ahora tory 9700 South Liss Avenue Argonne, I i, 6043’) F. J. les 705 Buffalo D~rive Arlington, TX 76013 C. (irandy tUriion Flect nc CoI. P.O. Box 14’) St Louis. MO ( 3101 59

  9. Het onderzoek van Paul Belder : "Fosfaat vraagt veel rekenwerk van teler"

    NARCIS (Netherlands)

    Dwarswaard, A.

    2009-01-01

    De serie Het onderzoek van... laat onderzoekers vertellen waar zij op dit moment bezig zijn. In deze aflevering Paul Belder, onderzoeker bodem, water en bemesting bij PPO Lisse over projecten die alles te maken hebben met hyacint, organische stof en fofaat

  10. Genetic diversity of pheasants from natural habitat and farm ...

    African Journals Online (AJOL)

    Roman

    2013-05-01

    May 1, 2013 ... 1Department of Biological Basis of Animal Production, Faculty of Animals' Biology and Breeding, ... Pheasants living in the natural environment were ... habitat is the farm, and the present genetic variation between the two ... wildlife management with respect to pheasants in Poland ..... Wiley-Liss, New York.

  11. De gecombineerde rol van ethyleen en het pelmoment in het ontstaan van zuur in tulp

    NARCIS (Netherlands)

    Dam, van M.F.N.; Kreuk, F.

    2010-01-01

    Proeftuin Zwaagdijk (de Zuurgroep West Friesland) en PPO-Bloembollen te Lisse deden de laatste jaren beide onderzoek naar zuur in tulp. Bij PPO werd gevonden dat ethyleen al binnen enkele uren tot dagen een belangrijke rol speelt bij toename van zuurgevoeligheid van de bollen. Uit onderzoek van Proe

  12. The 'Stained Glass Procedure', a new method to compare classification performance of images acquired with different pixel sizes

    NARCIS (Netherlands)

    Addink, E.A.; Clevers, J.G.P.W.; Jong, de S.M.; Epema, G.F.; Meer, van der F.D.; Skidmore, A.K.; Bakker, W.H.

    2006-01-01

    Objective comparison of classification performance of earth observation images, acquired at different spatial resolutions (e.g. NOAA-AVHRR, IRS-MOS, IRS-WiFS, Landsat-TM, IRS-LISS), is complicated because both class definition and training site selection are hampered by the inherent scale difference

  13. Land use/land cover changes around Rameshwaram Island, east coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Gowthaman, R.; Dwarakish, G.S.; Sanilkumar, V.

    Land-use/land cover changes are studied using the Indian Remote Sensing satellite (IRS-1C, IRS-6) Linear Image Self-scan Sensor (LISS) III data of 1998 and 2010 Coastal land use categories such as sand, vegetation, coral reef and water have been...

  14. Discordance for Schimmelpenning-Feuerstein-Mims syndrome in monochorionic twins supports the concept of a postzygotic mutation.

    Science.gov (United States)

    Rijntjes-Jacobs, Esther G J; Lopriore, Enrico; Steggerda, Sylke J; Kant, Sarina G; Walther, Frans J

    2010-11-01

    The Schimmelpenning-Feuerstein-Mims (SFM) syndrome comprises a craniofacial nevus sebaceus, seizures, developmental delay, ocular and skeletal abnormalities. It is a sporadic condition and hypothesized to result from mosaicism involving a lethal autosomal dominant gene. We report a second occurrence of discordant monozygotic (MZ) twins with severe SFM, supporting the concept of a postzygotic mutation. © 2010 Wiley-Liss, Inc.

  15. Pigmentation in Anuran Testes: Anatomical Pattern and Variation

    OpenAIRE

    Franco-Belussi, Lilian [UNESP; Zieri, Rodrigo [UNESP; de Souza Santos, Lia Raquel; Moresco, Rafaela Maria; Oliveira, Classius de [UNESP

    2009-01-01

    In amphibians, pigmented cells are present in several organs, composing an extracutaneous pigmentary system. Seventeen species from two families were studied to develop a protocol for pigmentary classification. The amount and distribution of these cells are variable, allowing the establishment of anatomical patterns for visceral pigmentation in anuran testes. Anat Rec, 292:178-182, 2009. (C) 2008 Wiley-Liss, Inc.

  16. Alternatieven voor onkruidbestrijding met paraquat in zomerbloemen

    NARCIS (Netherlands)

    Bulle, A.A.E.; Koster, A.T.J.; Trompert, J.P.T.

    2009-01-01

    In de teelt van zomerbloemen werden voor de bestrijding van onkruid middelen gebruikt op basis van de werkzame stof paraquat-dichloride. Per augustus 2007 is dit middel ingetrokken. Op korte termijn was een noeiuwe methode nodig. PPO Lisse heeft onderzoek gedaan naar de potentiële alternatieve onkru

  17. Testosterone Correlates with Venezuelan Equine Encephalitis Virus in Macaques

    Science.gov (United States)

    2006-03-29

    19], and azoosper- mia has been associated with SIV infection in young male rhesus macaques [20]. Depressed androgen levels during physiological...Cytokine Networks in Tissue Immunity Edited by: Meltzer MS, Mantovani A. New York:Wiley-Liss; 1991:77-82. 11. Muehlenbein MP, Bribiescas RG

  18. Education and support for representative, direct and stealth democracy

    NARCIS (Netherlands)

    Coffé, Hilde; Michels, Ank

    2014-01-01

    Using data collected within the scope of a Dutch internet panel survey (LISS) in 2011, this study tracks public support for direct, stealth and representative democracy according to educational level. Our findings indicate that, in terms of overall support for each specific type of democracy, lower

  19. Revascularization of a central vein total occlusion via antegrade and retrograde approach in a patient with hemodialysis access.

    Science.gov (United States)

    Fang, Hsiu-Yu; Hsieh, Yuan-Kai; Wu, Chiung-Jen

    2010-12-01

    The occurrence of central vein total occlusion results in upper arm edema, pain, and hemodialysis access failure in uremic patient. Previous studies have proven the effectiveness of percutaneous balloon angioplasty for central vein total occlusion. Here, we report a rare case of successful revascularization of central vein total occlusion via antegrade and retrograde approach. Copyright © 2010 Wiley-Liss, Inc.

  20. taenia coli de cobaye

    African Journals Online (AJOL)

    AKA BOKO

    of the rhythmical contraction of guinea pig Taenia coli smooth muscle. ... déterminer le mécanisme d'action de ces composés. 2. Matériel et ..... [34, 35]. Il rappelle les effets de l'acétylcholine sur les muscles lisses viscéraux [36- 38]. Pour cela.

  1. Original Paper Etude des effets vermicide et anti-diarrhéique du ...

    African Journals Online (AJOL)

    induite par l'acétylcholine 0,35 µM, ont été inhibées par le macéré aqueux des feuilles de Salvadora persica, L. ... spectre d'action, pour faire face à ces ..... le muscle lisse intestinal du lapin. ..... contractions in longitudinal smooth muscle.

  2. Heat Shock Proteins in Human Endometrium Throughout the Menstrual Cycle

    Directory of Open Access Journals (Sweden)

    S. Tabibzadeh

    1999-01-01

    (TNF-α is a cytotoxic cytokine that is produced in progressive amounts during the secretory phase. The function of the Hsps may be to protect cells against the cytotoxic damage of TNF-α, particularly during the critical period of “implantation window.” Infect. Dis. Obstet. Gynecol. 7:5–9, 1999. (C 1999 Wiley-Liss, Inc.

  3. Vowel Acoustics in Dysarthria: Mapping to Perception

    Science.gov (United States)

    Lansford, Kaitlin L.; Liss, Julie M.

    2014-01-01

    Purpose: The aim of the present report was to explore whether vowel metrics, demonstrated to distinguish dysarthric and healthy speech in a companion article (Lansford & Liss, 2014), are able to predict human perceptual performance. Method: Vowel metrics derived from vowels embedded in phrases produced by 45 speakers with dysarthria were…

  4. Vowel Acoustics in Dysarthria: Mapping to Perception

    Science.gov (United States)

    Lansford, Kaitlin L.; Liss, Julie M.

    2014-01-01

    Purpose: The aim of the present report was to explore whether vowel metrics, demonstrated to distinguish dysarthric and healthy speech in a companion article (Lansford & Liss, 2014), are able to predict human perceptual performance. Method: Vowel metrics derived from vowels embedded in phrases produced by 45 speakers with dysarthria were…

  5. Discriminating Dysarthria Type from Envelope Modulation Spectra

    Science.gov (United States)

    Liss, Julie M.; LeGendre, Sue; Lotto, Andrew J.

    2010-01-01

    Purpose: Previous research demonstrated the ability of temporally based rhythm metrics to distinguish among dysarthrias with different prosodic deficit profiles (J. M. Liss et al., 2009). The authors examined whether comparable results could be obtained by an automated analysis of speech envelope modulation spectra (EMS), which quantifies the…

  6. Deep seating of six French guiding catheters for delivery of new Palmaz-Schatz stents

    NARCIS (Netherlands)

    vanBoven, AJ; denHeijer, P; Tio, RA; Lie, KI; Crijns, HJGM

    1996-01-01

    The delivery of new Palmaz-Schatz stents in native coronary arteries can be facilitated by using the technique of deep seating of a 6 French guiding catheter. Two patient histories are described to illustrate this new technique. (C) 1996 Wiley-Liss, Inc.

  7. Education and support for representative, direct and stealth democracy

    NARCIS (Netherlands)

    Coffé, Hilde|info:eu-repo/dai/nl/304824186; Michels, Ank|info:eu-repo/dai/nl/11124501X

    2014-01-01

    Using data collected within the scope of a Dutch internet panel survey (LISS) in 2011, this study tracks public support for direct, stealth and representative democracy according to educational level. Our findings indicate that, in terms of overall support for each specific type of democracy, lower

  8. Loomemajanduse jura on hullem kui vandenõu / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2010-01-01

    Vastukaja artiklile: Härm, Anders. Kui kultuurist saab ripats. Eesti Päevaleht, 2010, 13. dets., lk. 3. Loomemajandusest, mis tähendab lõputuid konverentse ja välissõite, tegelikust kultuuripoliitikast, mis seisneb lõpututes taandumislahingutes. Eesti filmi, oma loomu poolest tööstusliku kultuuriala seisust

  9. Kennismiddag veldproeven PPO : strategische oplossingen

    NARCIS (Netherlands)

    Dwarswaard, A.; PPO Bomen-bollen,

    2009-01-01

    Phytium in hyacint, Rhizoctonia in tulp, aaltjes in krokussen allemaal aandoeningen die aangepakt moeten worden om een kwalitatief goed product af te leveren. PPO onderzoekt veel van die strategiën. Tijdens de Kennismiddag veldproeven in Lisse, komt er een flink aantal aan de orde

  10. Ziek en Zeer : Erwinia chrysanthemi in Amaryllidaceae

    NARCIS (Netherlands)

    Vink, P.

    2011-01-01

    In dit artikel een verslag van het onderzoek naar de gevoeligheid van narcissen voor de bacterie Erwinia chrysanthemi (tegenwoordig Dickeya dadantii). Uit een infectieproef is gebleken dat deze bacterie tijdens een reguliere bollenteelt in Lisse niet in staat was om narcisbollen aan te tasten. Toch

  11. Choc anaphylactique au cours de la chirurgie de kyste hydatique du foie : à propos d’un cas

    Directory of Open Access Journals (Sweden)

    Mohame Boughalem

    2010-08-01

    Full Text Available Nous rapportons l’observation d’un choc anaphylactique survenue au cours d’une chirurgie de kystes hydatiques hépatiques multiples. Il s’agit d’un enfant de 13 ans, de sexe féminin, sans antécédents pathologiques notables, en particulier allergique, programmé pour cure chirurgicale de kystes hydatiques hépatiques multiples. L’examen préopératoire est strictement normal. La patiente est classée ASA (American Society of Anaesthesiologists I. L’intervention est réalisée sous anesthésie générale. Au moment de la manipulation du deuxième kyste, une augmentation des pressions d’insufflation apparaît, avec des râles sibilants au niveau des deux champs pulmonaires et une désaturation, suivi d’un collapsus vasculaire avec hypotension artérielle 50/30. La prise en charge est débutée aussitôt par un remplissage vasculaire par du sérum salé 9%, suivi par des bolus d’adrénaline de 0,1mg à trois reprises, puis d’une perfusion continue à raison. L’adrénaline est arrêtée au bout de 48 heures et la patiente est adressée au service de chirurgie à j+4 de l’intervention. Le choc anaphylactique est une complication connue de la rupture intra péritonéale spontanée ou post-traumatique du kyste hydatique du foie. Sa survenue en peropératoire est devenue exceptionnelle, grâce aux mesures de prévention chirurgicale entretenues en peropératoire par l’éviction de manipulation du kyste, de le vider avant d’injecter le scolicide, et de ne pas l’administrer sous forte pression.

  12. Classification moléculaire du cancer du sein au Maroc

    Science.gov (United States)

    Fouad, Abbass; Yousra, Akasbi; Kaoutar, Znati; Omar, El Mesbahi; Afaf, Amarti; Sanae, Bennis

    2012-01-01

    Introduction La classification moléculaire des cancers du sein basée sur l'expression génique puis sur le profil protéique a permis de distinguer cinq groupes moléculaires: luminal A, luminal B, Her2/neu, basal-like et non-classées. L'objectif de cette étude réalisée au CHU Hassan II de Fès est de classer 335 cancers du sein infiltrant en groupes moléculaires, puis de les corréler avec les caractéristiques clinicopathologiques. Méthodes Etude rétrospective étalée sur 45 mois, comportant 335 patientes colligées au CHU pour le diagnostic et le suivi. Les tumeurs sont analysées histologiquement et classées après une étude immunohistochimique en groupes: luminal A, luminal B, Her2+, basal-like et non-classées. Résultats 54.3% des tumeurs sont du groupe luminal A, 16% luminal B, 11.3% Her2+, 11.3% basal-like et 7% non-classées. Le groupe luminal A renferme le plus faible taux de grade III, d'emboles vasculaires ainsi que de métastases; alors que le groupe des non-classées et basal-like représentent un taux élevé de grade III, une faible proportion d'emboles vasculaires et d'envahissement ganglionnaire. Ces facteurs sont significativement élevés dans les groupes luminal B et Her2+ avec un taux de survie globale de 78% et 76% respectivement. Dans le groupe luminal A, la survie globale des patientes est élevée (87%) alors qu'elle n'est que de 49% dans le groupe des triples négatifs (basal-like et non-classés). Conclusion Le groupe luminal B est différent du luminal A et il est de pronostic péjoratif vis à vis du groupe Her2+. Les caractéristiques clinicopathologiques concordent avec le profil moléculaire donc devraient être pris en considération comme facteurs pronostiques. PMID:23396646

  13. Le sujet âgé en hémodialyse chronique: expérience d'un centre hospitalier marocain

    Science.gov (United States)

    Karimi, Ilham; Benabdellah, Nawal; Bentata, Yassamine; Haddiya, Intissar

    2013-01-01

    De plus en plus de patients âgés sont pris en charge en hémodialyse chronique. L'augmentation de l'incidence de la maladie rénale chronique, du diabète et l'amélioration de la survie cardio-vasculaire expliquent en grande partie ce constat. Les conséquences de la prise en charge de ces patients âgés en en hémodialyse chronique sont multiples. Elles sont dominées par les comorbidités et les troubles d'autonomie. Le but de notre étude est de décrire le profil épidémiologique et clinique des patients âgés traités par HDC dans notre centre. Nous avons réalisé une étude transversale, en Novembre 2011, incluant tous les patients hémodialysés chroniques de l'Hôpital Al Farabi d'Oujda, dans la région de l'Oriental Marocain. Nous avons analysé chez les patients âgés de 65 ans et plus les paramètres démographiques, clinico-biologiques et dialytiques. L'analyse statistique est réalisée par le logiciel SPSS 17,0. Parmi 94 patients hémodialysés chroniques actuellement pris en charge dans notre centre, 31patients sont âgés de 65 ans et plus (32,9%). La néphropathie causale était diabétique dans 6,4% des cas, vasculaire dans 19,35% des cas, et glomérulaire dans 20% des cas. Les comorbidités sont observées chez 65% de ces patients. 29% de patients avaient une comorbidité cardiovasculaire, 55% étaient hypertendus, alors que 6,4% avaient des troubles cognitifs. Les sujets âgés en hémodialyse chronique représentent une population de patients fragiles. Ils nécessitent une surveillance particulière et régulière afin de prévenir certaines complications propres au sujet âgé et améliorer ainsi leur qualité de vie. PMID:24009801

  14. Effect of high energy electrons on the skin and on the underlying tissues of the rabbit. A clinical and histological study; Effets des electrons de haute energie sur la peau et les tissus sous-jacents du lapin. Etude clinique et histologique

    Energy Technology Data Exchange (ETDEWEB)

    Legeay, G.; Vialettes, H.; Adnet, J.J.; Court, L.; Masse, R. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1967-07-01

    The authors consider in this report the effects of high-energy electrons on rabbit teguments and on the underlying tissues after a single high dose irradiation. After briefly considering the mechanism of interaction between the electrons and matter as a function of their energy, the authors describe the dosimetry carried out, as a function of the irradiation device. The animal received surface doses of 5700 to 22100 rads in the thigh; the electron energy varied from 21 to 30 MeV. A clinical study was carried out over a period of nine months with a view to following the evolution of the damage and the functional degradation of the underlying tissues. A histological study of the induced damage was made after a second irradiation using 30 MeV electrons to produce doses of 16400 rads. Interesting observations were made concerning the damage caused to muscular and nerve tissues. (authors) [French] Les auteurs etudient, dans ce rapport, les effets des electrons de haute energie sur les teguments du lapin et les tissus sous-jacents apres une irradiation unique a dose elevee. Apres un rappel du mecanisme de l'interaction des electrons avec la matiere en fonction de leur energie, la dosimetrie realisee est exposee en fonction du dispositif d'irradiation. Les animaux ont recu, au niveau de la cuisse, des doses en surface de 5700 a 22100 rads; les energies des electrons vont de 21 a 30 MeV. Une etude clinique des lesions, observees pendant 9 mois, decrit leur evolution ainsi que les alterations fonctionnelles des tissus sous-jacents. Une etude histologique des lesions induites a ete realisee au cours d'une seconde experience pour des doses de 16400 rads avec des electrons de 30 MeV. D'interessantes observations ont ete faites concernant les lesions des tissus musculaires et nerveux. (auteurs)

  15. Tuberculose multifocale chez les immunocompétents

    Science.gov (United States)

    Rezgui, Amel; Fredj, Fatma Ben; Mzabi, Anis; Karmani, Monia; Laouani, Chadia

    2016-01-01

    La tuberculose multifocale est définie par la l'atteinte d'au moins deux sites extra-pulmonaires associée ou non à une atteinte pulmonaire. On se propose d’étudier les différentes caractéristiques cliniques et évolutives de la tuberculose multifocale à travers une étude rétrospective de 10 cas. Parmi 41 cas de tuberculose colligés entre 1999 et 2013. Dix patients avaient une tuberculose multifocale, soit 24% des patients. Il s'agissait de 9 femmes et 1 homme d’âge moyen à 50 ans (30-68 ans). Nos patients étaient tous correctement vaccinés par le BCG. Un bilan à la recherche d'une éventuelle immunodépression fait pour tous les patients était négatif. Il s'agissait d'une tuberculose ganglionnaire dans 7 cas, digestive dans 3 cas, péricardique dans 2 cas, ostéo-articulaire dans 2 cas, cérébrale dans 1 cas, urinaire dans 2 cas, uro-génitale dans 4 cas, surrénalienne dans 1 cas, cutanée dans 1 cas et musculaire dans 1 cas. Tous nos patients ont bénéficié d'un traitement antituberculeux pour une durée moyenne de 10 mois avec bonne évolution. La tuberculose multifocale est une des maladies à diagnostic difficile. Elle peut toucher les immunocompétents mais son pronostic est souvent bon. Un traitement anti-tuberculeux doit être instauré le plus rapidement possible pour éviter les séquelles. PMID:27583077

  16. Effect comparison of two different treatments of tibia and fibula complex fracture%胫腓骨近干骺端复杂骨折两种治疗对比分析

    Institute of Scientific and Technical Information of China (English)

    杨二平; 彭昊; 胡冰; 程子林

    2012-01-01

    Objective To evaluate and compare the clinical outcomes of two different treatments for complicated tibia and fibula fracture, less invasive stabilization system( LISS )and anatomical plate. Methods From October 2005 to August 2010,49 patients with complicated tibia and fibula fractures were treated with LISS or anatomical plate( 31 cases in anatomical plate group, and 18 cases in LISS group ). Based on AO classification,there were 8 1A3 cases,6 2C1,8 2C2,and 9 2C3 in anatomical plate group, and 5 1A3 cases,4 2C1,3 2C2,and 6 2C3 in LISS group. The patients in LISS group were treated with locked plate, and the patients in anatomical plates group were reduced via the incision and treated with anatomical plates. All patients were followed for 12 to 18 months. Outcomes were compared by analyzing the operative duration,blood loss, incision length,postoperative drainage volume and fracture healing time. Results The patients were followed up for 10 ~ 36 months postoperatively with an average of 14. 5 months. The operative duration, blood loss, incision length, postoperative drainage volume and fracture healing time were significantly improved in the LISS group than those in the anatomical plate group. Conclusion LISS and anatomical plate can both obtain satisfactory outcomes in our study. Less invasive stabilization system has angel stability. LISS provides an alternative treatment for the complicated distal femoral fractures, and it is new trend. There are fewer traumas, fewer blood losses and more rapid recovery in this approach. LISS is an ideal approach for internal fixation in treatment of severe tibia and fibula comminuted fracture. Proper surgery indications, rigid operation procedures and careful management of bone defect are the keys to optimal curative effect.%目的 回顾性分析胫腓骨严重多段骨折两种治疗方法 的疗效,探讨其手术相关问题和比较两种治疗方法 优越性.方法 应用LISS钢板及解剖接骨钢板治

  17. Study of a case of essential hypoproteinaemia using the isotopes {sup 131}I and {sup 15}N; Etude a l'aide des isotopes {sup 131}I et {sup 15}N d'un cas d'hypoproteinemie essentielle

    Energy Technology Data Exchange (ETDEWEB)

    Dubert, A.; Coursaget, J.; Fallot, P.; Royer, P. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires; Hopital des Enfants Malades, 75 - Paris (France)

    1959-07-01

    Hypoproteinaemia both human and experimental has been studied with the help of nuclear labelling. A comparative study has been made of the fate of serum proteins labelled by an endogenous path after administration of nitrogen-15 glycine and also of serum albumin labelled by exogenous path using iodine-131. We have determined the biological period of the serum albumin and serum globulins and also the magnitude of the vascular and extravascular pools of serum albumin. In this way it has been possible to measure the speed of replacement of plasma proteins. A presentation of results taken from both clinical observation and experiment leads to a discussion on the pathogenic mechanism of hypoproteinaemia. (author) [French] Les hypoproteinemies humaine et experimentale ont ete explorees a l'aide d'indicateurs nucleaires. Une etude comparative du devenir des proteines seriques marquees par voie endogene, apres administration de glycocolle-{sup 15}N et de l'albumine serique marquee par voie exogene a l'iode-131 a ete realisee. On a determine la periode biologique de la serumalbumine et des globulines seriques ainsi que la grandeur des 'pools' vasculaire et extravasculaire de la serumalbumine. Il a ete ainsi possible d'evaluer la vitesse de renouvellement des proteines plasmatiques. La confrontation des resultats tires de l'observation clinique et de l'experimentation conduit a une discussion sur le mecanisme pathogenique de l'hypoproteinemie. (auteur)

  18. Pontage fémoro-fémoral croisé avec tunnulisation périnéale sous-scrotale pour une infection grave du triangle de scarpa

    Science.gov (United States)

    Mrad, Melek Ben; Miri, Rim; Kaouel, Karim; Derbel, Bilel; Tarzi, Mariem; Ghedira, Faker; Kalfat, Tawfik; Mizouni, Hbiba; Khayati, Adel

    2015-01-01

    Nous décrivons dans cet article une technique de revascularisation des patients ayant une infection de prothèse vasculaire sus-crurale au niveau dutriangle de scarpa, et qui minimise le risque d'infection récurrente du greffon. Cette technique consiste en un pontage fémoro-fémoral croisé avec un tunnel périnéal sous-cutané loin du scarpa infecté que le tunnel classique sus-pubiensous-cutané ne permet pas. Nous rapportons le cas d'un patient âgé de 52 ans, artéritique, multi-opérés, admis pour infection du scarpa droit sur un pontage fémoro-fémoral prothétique perméable, le patient a eu une explantation de ce pontage et une revascularisation par un pontage périnéal sous-scrotal veineux loin du site infectieux; l’évolution a été excellente et le pontage est encore perméable après deux ans de suivi. Le pontage fémoro-fémoral périnéal est une procédure exceptionnellement réalisée, mais qui peut constituer une vraie option thérapeutique de revascularisation chez les patients avec une infection du scarpa. PMID:26955419

  19. [Personalized treatment of varices. Indications in thirty-two cases].

    Science.gov (United States)

    Mellière, D; Baudin, V; Martin-Jonathan, C

    1994-01-01

    During the 28th Meeting of the Collège Français de Pathologie Vasculaire, twelve experts, six angiologists and six surgeons were asked to choose a first intention treatment for 32 case reports of patients with varicose veins based on physical examinations and écho-Doppler findings. The audience made their choice simultaneously by an electronic voting system. In a large number of cases, several therapeutic options were possible. The greater saphenous vein can often be retained in first intention situations with the possibility that several years later the prognosis of the limb may depend on the presence of this vein, particularly in life threatening cases where it is needed for arterial bypass surgery. In some cases it is clear that the greater saphenous vein does not need to be removed and in others, deterioration is clearly sufficient to justify removal. In many cases, the choice between the two options is a decision to be made. Indications depend on the clinical presentation and echo-Doppler findings. The caliber of the greater saphenous vein must be determined for the entire length of the vein. Whenever possible, veins with a diameter below 8 mm should be preserved and the patients should be informed on why the choice was made. Whatever treatment has been chosen, recurrence may be observed and periodic follow-up is required.

  20. Hémangiome fusiforme: une localisation inhabituelle

    Science.gov (United States)

    Nasreddine, Fatima Zahra; Baghad, Bouchra; Chiheb, Soumiya

    2016-01-01

    L'hémangiome à cellules fusiformes été décrit par Weiss et Enzinger en 1986 et anciennement nommé hémangioendothéliome à cellules fusiformes. Depuis l'avènement des études immunohistochimique il n'est plus considéré en tant qu'angiosarcome de bas grade. C'est une tumeur bénigne vasculaire. Il touche presque exclusivement le derme des extrémités distales. Nous rapportons le premier cas avec localisation au niveau de l'omoplate, du sein, des cuisses et de la mandibule. Selon la littérature, seulement 9 cas localisés au niveau de la tête et le cou ont été rapportés. Nous rapportons un nouveau cas de cette entité rare et mal connue qui peut prêter confusion avec les tumeurs malignes. Notre patient avait une localisation au niveau de l'omoplate, du sein, des cuisses et de la mandibule. Une biopsie-exérèse était réalisée. L’évolution a été favorable avec un recul de 6 mois, sans rechute. PMID:27642429

  1. A mathematical model of inflammation during ischemic stroke

    Directory of Open Access Journals (Sweden)

    Dronne Marie-Aimée

    2010-12-01

    Full Text Available In this article we propose a model to describe the inflammatory process which occurs during ischemic stroke. First, an introduction to some basic concepts about the biological phenomenon is given. Then, a detailed derivation of the model and the numerical scheme used are presented. Finally, the studies of the model robustness and sensitivity are showed and some numerical results on the time and space evolution of the process are presented and discussed. Dans cet article, nous nous attachons à modéliser le processus inflammatoire lors d’un accident vasculaire cérébral ischémique. Tout d’abord, nous expliquons brièvement les bases biologiques de ce phénomène. Puis, nous décrivons les équations et les schémas numériques retenus pour le modéliser et l’implémenter. Nous présentons ensuite des études de robustesse et de sensibilité et montrons et discutons les premiers résultats de simulation obtenus.

  2. Profil épidémiologique de l'insuffisance rénale terminale à l'hôpital Militaire de Rabat, Maroc

    Science.gov (United States)

    Asserraji, Mohammed; Maoujoud, Omar; Belarbi, Marouane; Oualim, Zouhir

    2015-01-01

    L'Insuffisance rénale chronique terminale (IRCT) est un enjeu majeur de sante publique au Maroc à cause de ses conséquences médicales et socioéconomiques. L'objectif de ce travail est d’évaluer le profil épidémiologique de l'IRCT à l'hôpital militaire de rabat, Maroc. Il s'agit d'une enquête rétrospective pendant quatre ans (1er janvier 2007 au 31 décembre 2010). Tous les cas d'IRCT (diminution permanente du débit de filtration glomérulaire (DFG) dialyse durant cette période, 130 hommes (64%) et 73 femmes (36%), l’âge moyen était de 49,92 ans (06 - 80 ans). la néphropathie d'origine indéterminée représente la première cause d'IRCT dans notre série (27,1%) suivie de la néphropathie diabétique (24,6%), des glomérulonéphrites chroniques (22,7) et de la néphropathie d'origine vasculaire (10,8%). 131 patients (64,5%) n'ont pas eu de suivi néphrologique pré dialytique. une prise en charge globale de cette pathologie est nécessaire. PMID:26309471

  3. A case of rare anti-Xga antibody in Xg blood group system%罕见Xg血型系统抗-Xga 1例

    Institute of Scientific and Technical Information of China (English)

    侯玉涛; 张亚臣; 郑超

    2014-01-01

    目的 鉴定1例Xg血型系统抗-Xga并进行交叉配血.方法 采用血清学方法鉴定ABO和RhD血型,采用盐水介质和LISS-IAT法做抗体鉴定,采用Liss/Coombs卡进行交叉配血.结果 经鉴定抗体为抗-xga,患者与10位献血员进行交叉配血相合2人,相合者均为男性.结论 引起交叉配血不相合的抗体为Xg血型系统抗-Xga.

  4. 不同内固定方法治疗股骨远端骨折的疗效分析%The comparative analysis of the clinical effect of different fixation methods in the treatment of distal femur fracture

    Institute of Scientific and Technical Information of China (English)

    杜峰; 侯辉宝; 程树银

    2016-01-01

    Objective:To explore the clinical effects of Liss and GSH in the treatment of distal femur fracture. Methods:According to the AO typing,patient′s physical condition and local soft tissue situation,the type A1,A2,A3,C1 and C2 in 19 patients( GSH group) and type A1,A2,A3,C1,C2 and C3 in 18 patients(Liss group) were treated with GSH and Liss,respectively. The fracture healing time and HSS scores between two groups were compared. Results:All cases were followed up. The fractures were anatomically reset,and the incision was smooth healed. The heal time of fractures in GSH and Liss group were(5. 0 ± 1. 2) and(4. 8 ± 1. 17) months,respectively, the difference of which was not statistically significant(P>0. 05). The HSS knee scores in GSH and Liss group were(89. 4 ± 10. 6) and(89.9±11.11),respectively,the difference of which was not statistically significant(P>0.05).Conclusions:The treatment of distal femur fracture with Liss and GSH can achieve good effects,the difference of which is no obvious.%目的::探讨Liss钢板( Liss)与逆行铰锁髓内钉( GSH)内固定治疗股骨远端骨折的临床疗效。方法:根据AO分型,结合患者身体条件及局部软组织情况,A1、A2、A3及C1、C2型19例选用GSH( GSH组),A1、A2、A3及C1、C2、C3型18例选用Liss ( Liss组),比较2组骨折愈合时间及HSS评分情况。结果:37例均获随访,骨折解剖复位,切口顺利愈合。 GSH组骨折愈合时间为(5.0±1.2)个月,Liss组愈合时间为(4.8±1.17)个月,2组差异无统计学意义(P>0.05)。 GSH组膝关节HSS评分(89.4±10.6)分,Liss组(89.9±11.11)分,2组差异亦无统计学意义(P>0.05)。结论:Liss内固定治疗股骨远端骨折疗效与GSH内固定疗效相当,均能取得良好的效果。

  5. D1S80 polymorphism, including a new variant, in a population sample from Barcelona (Spain) using polymerase chain reaction.

    Science.gov (United States)

    Gené, Manel; Moreno, Pasqual; Huguet, Emili; Corbella, Jacint; Mezquita, Jovita

    1993-01-01

    Allele and genotype frequencies for the D1S80 (MCT118) locus have been determined in a population sample from Barcelona (Spain) using the polymerase chain reaction (PCR) amplification and nonradioactive detection. In a total of 216 unrelated individuals, 24 alleles (23 common and 1 rare variant) and 67 genotypes (64 common and 3 variants) were observed. The 216 individuals came from 162 blood samples taken for paternity studies, 16 bloodstains from forensic cases, and 38 root hairs from normal individuals. The D1S80 locus demonstrated a heterozygosity of 0.7916, and a power of discrimination of 0.9731. The distribution of genotypes is in agreement with expected values according to the Hardy-Weinberg equilibrium. Additionally, the population from Barcelona differs, significantly, from the Finnish population and also, but with lower differences, from a U.S.A. Caucasian population. © 1993 Wiley-Liss, Inc. Copyright © 1993 Wiley-Liss, Inc., A Wiley Company.

  6. A systematic review of studies on psychosocial late effects of childhood cancer: structures of society and methodological pitfalls may challenge the conclusions

    DEFF Research Database (Denmark)

    Lund, Lasse Wegener; Schmiegelow, Kjeld; Rechnitzer, Catherine

    2011-01-01

    High survival rates after childhood cancer raise attention to possible psychosocial late effects. We focus on predictors of psychosocial outcomes based on diagnosis, treatment, demography, somatic disease, and methodological problems. Overall, survivors evaluate their health-related quality of li....... Significant methodological problems hamper current knowledge. Systematic registration of psychosocial and somatic problems at diagnosis and prospectively through protocols is needed. Pediatr Blood Cancer © 2010 Wiley-Liss, Inc....

  7. Molecular design of DABNTf as a highly efficient resolving reagent for racemic Pd complex with Tropos biphenylphosphine (BIPHEP) ligand: circular dichroism (CD) spectra of enantiopure BIPHEP-Pd complex.

    Science.gov (United States)

    Mikami, Koichi; Yusa, Yukinori; Aikawa, Kohsuke; Hatano, Manabu

    2003-01-01

    The racemic Pd complexes with chirally flexible (tropos) biphenylphosphine (BIPHEP) ligands can be resolved but transformed into the enantio- and diastereo-pure complex. The enantiopure metal complex of BIPHEP ligand is thus obtained through enantiomer-selective complexation of a racemic BIPHEP-Pd complex with enantiopure 1,1'-binaphthyl-2,2'-di(triflyl)amide, DABNTf. The differential CD spectra of the enantiopure BIPHEP-Pd complex is also reported. Copyright 2002 Wiley-Liss, Inc.

  8. Mass Transfer Coefficients and Henry’s Constants for Packed-Tower Air Stripping of Volatile Organics: Measurements and Correlation.

    Science.gov (United States)

    1985-06-01

    Himmelblau , 1970; Onda et al., 1968; Liss and Martinelli, 1978; Smith et al., 1980). A surface-active substance (surfactant) can alter the rate of mass...i.1--,’ -:-- L’ Using a nonexperimental approach, Ferrell and Himmelblau (1967) noted another restriction in the...and Himmelblau (1964) cite the use of estimated molar volumes as one reason fo,- the deviation between experimental and calculated diffusi- vities

  9. Dominantly-inherited lop ears.

    Science.gov (United States)

    Leung, Alexander K C; Kong, Albert Y F; Robson, W Lane M; McLeod, D Ross

    2007-10-01

    We describe a four-generation Chinese family that included five members who had an isolated bilateral lop ear anomaly. The presentation suggested a dominant mode of inheritance. The absence of male-to-male transmission does not exclude an X-linked dominant mode of inheritance. Since the phenotypic anomaly of the male proband was no more severe than the affected female members, an autosomal dominant mode of inheritance is most likely. 2007 Wiley-Liss, Inc

  10. Neuromodulation of Natural Killer Cell Activity

    Science.gov (United States)

    1989-01-01

    between the pineal gland As we have seen, NK cell function is ex- and the mitotic activity of some tissues. Arch Sci Biol tremely sensitive to many...34 New York: Alan R. Liss. Inc,. pp 151 - plasis. BriJ Med psychol 43:313-331. 160. Das Gupta TIC. Terz J (1967): Infuence of pineal gland Hochman PS...1968; Baron and D Gupta, 1970). responsiveness in patients with cerebral tu- Chemical sympathectomy renders rats highly mors (Brooks et al., 1972

  11. Emerging technologies including robotics and natural orifice transluminal endoscopic surgery (NOTES) colorectal surgery.

    Science.gov (United States)

    Whiteford, Mark H; Swanstrom, Lee L

    2007-12-15

    Endoluminal and minimally invasive techniques have a long history and bright future in colorectal surgery. First, we will examine how old (colonoscopy) and new (laparoscopy) techniques combine in the form of laparoscopically assisted colonoscopic polypectomy for removal of "colonoscopically unresectable" colon polyps. Next, we will review the early experiences with robot-assisted minimally invasive colon resections. Lastly, we will introduce the next frontier in minimally invasive surgery, natural orifice transluminal endoscopic surgery (NOTES). 2007 Wiley-Liss, Inc

  12. Craniosynostosis, telecanthus, scalp hair abnormalities, and sensorineural deafness in two sibs.

    Science.gov (United States)

    Mégarbané, André; Hersh, Joseph H; Chouery, Eliane; Fabre, Michel

    2002-05-15

    A sister and a brother with anomalous skull configuration, facial abnormalities, abnormal scalp hair growth, sensorineural hearing loss and, in the boy, proven craniosynostosis, severe mental retardation, and autism were reported in 1986 in an abstract by Hersh et al. We reexamined this family and here review the literature focusing on the major clinical findings, and suggest that their clinical manifestations may represent a previously unreported syndrome. Copyright 2002 Wiley-Liss, Inc.

  13. Protein Structure and the Sequential Structure of mRNA

    DEFF Research Database (Denmark)

    Brunak, Søren; Engelbrecht, Jacob

    1996-01-01

    A direct comparison of experimentally determined protein structures and their corresponding protein coding mRNA sequences has been performed, We examine whether real world data support the hypothesis that clusters of rare codons correlate with the location of structural units in the resulting pro...... nucleotide features of 16S-like ribosomal RNA sequences and related to mechanisms for maintaining the correct reading frame by the ribosome. (C) 1996 Wiley-Liss, Inc....

  14. Severe intravascular hemolysis after transcatheter closure of a large patent ductus arteriosus using the Amplatzer duct occluder: successful resolution by intradevice coil deployment.

    Science.gov (United States)

    Joseph, George; Mandalay, Asishkumar; Zacharias, T U; George, Biju

    2002-02-01

    A 21-year-old female developed severe unremitting intravascular hemolysis following closure of a large patent ductus arteriosus using an Amplatzer duct occluder. Percutaneous deployment of fibered platinum coils within the nitinol wire cage of the Amplatzer duct occluder abolished the residual shunt through the device and resulted in cessation of intravascular hemolysis and reversal of its adverse sequelae. Copyright 2002 Wiley-Liss, Inc.

  15. Spatial variations of DMS, DMSP and phytoplankton in the Bay of Bengal during the summer monsoon 2001

    Digital Repository Service at National Institute of Oceanography (India)

    Shenoy, D.M.; Paul, J.T.; Gauns, M.; Ramaiah, N.; DileepKumar, M.

    on the distribution of DMS and DMSP in the northern Indian Ocean (Hatton, Malin & Liss 1999; Shenoy, Kumar & Sarma, 2000; Shenoy, Joseph, Kumar & George, 2002 Shenoy & Patil, 2003). The northern Indian Ocean is comprised of the Arabian Sea and the Bay of Bengal... flame photometric detector (FPD). Both DMS and DMSPt were analysed according to the method given of Turner, Malin, Bagander, & Leck, (1990) and is also detailed in Shenoy, Joseph, Kumar, & George, (2002) and Shenoy and Patil (2003). Briefly, a known...

  16. Analytical techniques and quality control in biomedical trace element research

    DEFF Research Database (Denmark)

    Heydorn, K.

    1994-01-01

    The small number of analytical results in trace element research calls for special methods of quality control. It is shown that when the analytical methods are in statistical control, only small numbers of duplicate or replicate results are needed to ascertain the absence of systematic errors cau....../kg. Measurement compatibility is obtained by control of traceability to certified reference materials, (C) 1994 Wiley-Liss, Inc....

  17. Estimation of LAI and above-ground biomass in deciduous forests: Western Ghats of Karnataka, India

    Science.gov (United States)

    Madugundu, Rangaswamy; Nizalapur, Vyjayanthi; Jha, Chandra Shekhar

    2008-06-01

    This study demonstrates the potentials of IRS P6 LISS-IV high-resolution multispectral sensor (IGFOV ˜ 6 m)-based estimation of biomass in the deciduous forests in the Western Ghats of Karnataka, India. Regression equations describing the relationship between IRS P6 LISS-IV data-based vegetation index (NDVI) and field measured leaf area index (ELAI) and estimated above-ground biomass (EAGB) were derived. Remote sensing (RS) data-based leaf area index (PLAI) image is generated using regression equation based on NDVI and ELAI ( r2 = 0.68, p ≤ 0.05). RS-based above-ground biomass (PAGB) image was generated based on regression equation developed between PLAI and EAGB ( r2 = 0.63, p ≤ 0.05). The mean value of estimated above-ground biomass and RS-based above-ground biomass in the study area are 280(±72.5) and 297.6(±55.2) Mg ha -1, respectively. The regression models generated in the study between NDVI and LAI; LAI and biomass can also help in generating spatial biomass map using RS data alone. LISS-IV-based estimation of biophysical parameters can also be used for the validation of various coarse resolution satellite products derived from the ground-based measurements alone.

  18. Evaluating the reliability of a novel neck-strength assessment protocol for healthy adults using self-generated resistance with a hand-held dynamometer.

    Science.gov (United States)

    Versteegh, Theo; Beaudet, Danielle; Greenbaum, Marla; Hellyer, Leah; Tritton, Amanda; Walton, Dave

    2015-01-01

    Objectif : Évaluer la convergence test-retest intra et intersessionnelle d'un nouveau protocole d'évaluation de la force du cou au moyen d'un dynamomètre portatif. Contexte: Une recension des écrits a révélé un manque de protocoles d'évaluation de la force du cou à la fois portables et fiables. La dynamométrie manuelle est une méthode portable et peu coûteuse d'évaluation de la force musculaire, mais elle n'est pas utilisée couramment pour évaluer la force du cou. Méthodes : On a utilisé un dynamomètre portatif pour évaluer la force du cou chez 30 participants en bonne santé. On a mesuré la force maximale en flexion cervicale, extension, flexion latérale, flexion latérale avec rotation et rotation pure en utilisant la main ipsilatérale pour appliquer une résistance isométrique pendant 3 secondes. On a pris trois mesures en 6 à 8 jours. Résultats : Les coefficients de corrélation intraclasse (CCI) de test-retest ont révélé une grande fiabilité variant de 0,94 à 0,97 dans le cas de toutes les directions vérifiées de l'essai 1 à l'essai 2 (fiabilité intrasessionnelle) [CCI (2,1), absolu]. Les valeurs CCI ont démontré une fiabilité intersessionnelle variant de bonne à élevée, variant de 0,87 à 0,95 dans le cas de toutes les directions mises à l'épreuve de l'essai 1 à l'essai 3 [CCI (2,1), absolu]. Conclusion : Les résultats indiquent qu'il est possible d'appliquer le protocole d'évaluation de la force du cou et du quadrant supérieur par les cinq positions d'essai en utilisant la dynamométrie manuelle, et qu'il produit une fiabilité variant de bonne à élevée.

  19. The office based CHIVA

    Directory of Open Access Journals (Sweden)

    Passariello F

    2013-09-01

    Full Text Available Fausto Passariello,1 Stefano Ermini,2 Massimo Cappelli,3 Roberto Delfrate,4 Claude Franceschi5 1Centro Diagnostico Aquarius, Napoli, Italy; 2Private Practice, Grassina, Italy; 3Private Practice, Firenze, Italy; 4Casa di Cure Figlie di Maria, Cremona, Italy; 5Hospital St Joseph, Service d'Explorations Vasculaires, Paris, France Abstract: The cure Conservatrice Hémodynamique de l'Insuffisance Veineuse en Ambulatoire (CHIVA can be office based (OB. The OB-CHIVA protocol is aimed at transferring CHIVA procedures to specialists rooms. The protocol will check the feasibility of OB-CHIVA, data pertaining to recurrence, and will offer the opportunity to study saphenous femoral junction (SFJ stump evolution, the role of the washing vessels and the arch recanalization rate, and gather new data about the effect of the length of the treated saphenous vein. A simplified diagnostic procedure will allow an essential ultrasound examination of the venous net while a schematic and easily readable algorithm guides therapeutic choices. The Riobamba draining crossotomy (RDC tactic is composed of a set of OB procedures. While some of these procedures are, at the moment, only proposals, others are already applied. Devices generally used in ablative procedures such as Light Amplification by Stimulated Emission of Radiation (LASER, radio frequency, steam, and mechanical devices are used in this context to serve to conservative interventions for CHIVA. New techniques have also been proposed for devalvulation and tributary disconnection. Detailed follow-up is necessary in order to determine the effects of therapy and possible disease evolution. Finally, information is added about the informed consent and the ethical considerations of OB-CHIVA research. Keywords: CHIVA, office based procedures, LASER, RF, steam

  20. Lignes directrices sur la prise en charge en soins primaires des céphalées chez l’adulte

    Science.gov (United States)

    Becker, Werner J.; Findlay, Ted; Moga, Carmen; Scott, N. Ann; Harstall, Christa; Taenzer, Paul

    2015-01-01

    Résumé Objectif Accroître l’utilisation d’approches éclairées par des données probantes pour diagnostiquer, investiguer et traiter en soins primaires les céphalées des patients. Qualité des données Une recherche documentaire exhaustive a été effectuée pour trouver des lignes directrices et des révisions systématiques publiées entre janvier 2000 et mai 2011. La grille d’évaluation de la qualité des recommandations pour la pratique clinique AGREE a servi à l’analyse critique des lignes directrices. Les 6 guides de pratique clinique de la plus grande qualité ont servi de base dans le processus d’adaptation. Message principal Un groupe d’élaboration multidisciplinaire de professionnels des soins primaires ont formulé 91 recommandations précises à l’aide d’un processus consensuel. Les recommandations portent sur le diagnostic, l’investigation et la prise en charge de la migraine, de la céphalée de tension, de la céphalée due à une surmédication et de la céphalée vasculaire de Horton. Conclusion Un guide de pratique clinique adapté au contexte des soins de santé au Canada a été produit en suivant un processus d’adaptation de lignes directrices dans le but d’aider les professionnels de toutes les disciplines des soins primaires à dispenser des soins éclairés par des données probantes aux patients souffrant de céphalées.

  1. Providing innovative solutions in a single pill: Servier's portfolio in hypertension.

    Science.gov (United States)

    Mourad, Jean-Jacques; Guillerm, Jean-Christophe

    2016-09-01

    Jean-Jacques Mourad & Jean-Christophe Guillerm speak to Henry Ireland, Drug Evaluation Editor: Jean-Jacques Mourad talks about his vision of the current landscape and unmet medical needs in the field of hypertension. Jean-Christophe Guillerm describes the family of antihypertensive treatments from Servier, which were designed to address the current challenges in the management of hypertension by providing an adapted solution to doctors and to the specific needs of each patient. Jean-Jacques Mourad currently works as Professor of Medicine and is the Head of the Hypertension Unit at the Hôpital Avicenne in Bobigny, France. He completed his academic degrees at the Pierre and Marie Curie University, Paris VI in the field of internal and vascular medicine in 1996, and in the area of cardiovascular medicine and pharmacology in 2001. He is the past president of the French League Against Hypertension (since 2012), and the former General Secretary of the French Microcirculation Society. He is the actual Scientific Secretary of the French Society of Hypertension. He is also a member of the administrative council of the Collège Français de Pathologie Vasculaire. His research focuses on the epidemiology of hypertension, arterial structure and function, determinants of adherence to chronic treatment and the effects of antihypertensive agents. He was involved in several studies and surveys. He is a co-author of more than 130 publications and of 900 communications presented at national and international meetings. Jean-Christophe Guillerm, joined the pharmaceutical industry 17 years ago. He is currently the Head of the Cardiovascular Division for Servier, in charge of both cardiology and hypertension's medical strategy at a global level. Prior to this, he was in charge of the diabetes and internal medicine franchise at a global level. He also has experience in French commercial operations.

  2. Comparison between the results of the two and three-dimensional numerical simulations in an aortic bifurcation model

    Science.gov (United States)

    Deplano, V.; Pelissier, R.; Rieu, R.; Bontoux, P.

    1994-01-01

    Bifurcations are vascular singularities of interest because they are the privileged sites of atherosclerosis deposits, particularly the sites corresponding to wall shear stress extrema. The purpose of this paper is to compare the two- and three-dimensional characteristics of the velocity fields, the shear stress distributions and the secondary flows in a symmetrical aortic bifurcation. The branching angle is equal to 60^{circ} and the branch-to-trunk area ratio to 0.8. The numerical simulations are performed using the FIDAP programme. Although restrictive by the hypotheses of steady flow and rigid channel, with rectangular cross-sections, this study shows the importance of the three-dimensional effects in particular as far as concerned the wall shear stress behaviours. Les bifurcations sont des singularités vasculaires présentant un intérêt particulier car elles sont le site privilégié de dépôts athéromateux ; la localisation de ces dépôts dépendant des valeurs maximum du cisaillement en paroi. L'objectif de cette étude est de comparer les caractéristiques bidimensionnels et tridimensionnels des champs de vitesse, de la distribution du cisaillement pariétal et des écoulements secondaires dans un modèle de bifurcation aortique. L'angle de bifurcation est de 60^{circ} et le rapport des sections branche fille branche mère est de 0,8. Les simulations numériques sont effectuées sur la base du logiciel FIDAP. Bien que restrictifs de part certaines hypothèses, écoulement permanent dans un modèle de bifurcation rigide avec des sections rectangulaires, ces travaux montrent l'importance des effets tridimensionnels notamment au niveau du cisaillement pariétal.

  3. Should we screen for masked hypertension in patient with vascular disease?

    Directory of Open Access Journals (Sweden)

    Pascal Delsart

    2010-05-01

    Full Text Available Pascal Delsart1, Philippe Marboeuf1, Cedric Delhaye2, Gilles Lemesle2, Claire Mounier-Vehier11Service de Médecine Vasculaire et Hypertension Artérielle, 2Service d’hémodynamique et de Cardiologie B, University Hospital of Lille, FranceBackground: The influence of hypertension on cardiovascular risk is well known. Ambulatory blood pressure measurement (ABPM is able to identify patients with masked hypertension (MH underdetected by clinical BP measurement. The benefit of screening for MH in a highrisk population was investigated.Aims: To detect MH in a population with no prior history of hypertension and medically treated for peripheral or coronary arterial disease.Methods: Thirty-eight consecutive patients with peripheral or coronary artery disease documented with arteriography, without a history of hypertension, and with an admission BP < 140/90 mmHg underwent ABPM after discharge. Ambulatory BP ≥ 125/80 mmHg were defined as MH.Results: MH was found in 11 patients (28.9%. The MH group had a mean systolic and diastolic hospitalization BP significantly higher (127 versus 115 mmHg, respectively, P = 0.002 and 76 versus 66 mmHg, P = 0.01, and tended to have a higher admission systolic BP and pulse pressure (127 versus 121 mmHg, respectively, P = 0.07; and 54 versus 46 mmHg, P = 0.06. The first BP measurement on the 24-hour ABPM was significantly higher in the MH group 140 versus 121 mmHg, P = 0.001, for systolic BP and 84 versus 74 mmHg, P = 0.03, for diastolic BP.Conclusions: MH was found in patients with documented and medically treated vascular disease. BP in the prehypertensive range is associated with MH. Systematic screening for MH in this high-risk population requires further investigation.Keywords: blood pressure, monitoring, masked hypertension, vascular disease

  4. Rupture utérine sur utérus bicorne à 12 semaines d'aménorrhée: à propos d'un cas

    Science.gov (United States)

    Itchimouh, Sanaa; Khabtou, Karima; Mahdaoui, Sakher; Boufettal, Houssine; Samouh, Naima

    2016-01-01

    La fréquence des malformations utérines ayant un impact sur la reproduction est difficile à apprécier. Leur mise en évidence nécessite un bilan spécifique (hystérosalpingographie, hystéroscopie, cœlioscopie). La fertilité spontanée peut être altérée en fonction du type d'anomalie utérine. Toutes ces anomalies peuvent avoir des répercussions sur l’évolution de la conception à type de fausses couches précoces et tardives, de grossesse extra utérine, de menace d'accouchement prématuré, d'accouchement prématuré, de pathologies vasculaires gravidiques et de retard de croissance intra-utérin. L'utérus bicorne est la plus connue des malformations et représente environ la moitié des anomalies de l'utérus. La survenue d'une telle grossesse constitue une situation à risque pouvant entraîner une mort maternelle, mais le diagnostic précoce et un bon suivi peut mener des grossesses à terme sur des utérus malformé. Le dépistage échographique devrait permettre la détection systématique de ce genre de cas afin de prendre préventivement les mesures qui s'imposent. Nous rapportons un cas de rupture utérine sur utérus bicorne unicervical sur grossesse à 12 semaines d'aménorrhée. PMID:27642490

  5. Composition en acide alphalinolénique des esters de cholestérol plasmatiques : un marqueur de consommation chez l’homme

    Directory of Open Access Journals (Sweden)

    Combe Nicole

    2002-07-01

    Full Text Available Le lien existant entre qualité et quantité des acides gras de l’alimentation, et santé est de plus en plus évident et défini, comme l’indique la revue des travaux plus spécifiquement consacrés aux implications dans le risque de maladies cardiovasculaires (MCV (cf. premier exposé de ce dossier. Néanmoins, si un grand nombre d’études épidémiologiques ou d’intervention ont permis d’aboutir à un consensus qui s’est traduit, en France, par la publication en 2001 des Apports Nutritionnels Conseillés [1], un débat perdure au sein de la communauté scientifique internationale sur les meilleurs apports en acides gras monoinsaturés versus poly-insaturés [2, 3]. Les études récentes de Rudel et al. [4-6] indiquent en effet que des singes nourris avec un régime très enrichi en acide oléique (18:1n-9 : 24% de l’apport énergétique développent une athérosclérose des artères coronaires qui pourrait être en relation avec l’accumulation subséquente d’oléate de cholestérol dans les LDL aux dépens du linoléate de cholestérol. Par ailleurs, eu égard aux effets bénéfiques reconnus à l’acide alphalinolénique (18:3n-3 vis-à-vis des risques d’infarctus du myocarde, de cardiopathie ischémique [7-9] et d’accident vasculaire cérébral [10, 11], le niveau de 18:3n-3 dans les esters de cholestérol (EC du plasma apparaît comme un bon indicateur de protection. En effet, l’étude conduite par Sandker et al. [12], sur deux groupes d’hommes âgés, issus des cohortes crétoises (Seven Countries Study et hollandaises (Zutphen Study, a permis de faire émerger l’intérêt de ce marqueur biologique. En moyenne, le pourcentage de 18:3n-3 mesuré dans les EC plasmatiques des Crétois était significativement plus élevé comparé à celui des Hollandais (0,9% vs 0,32% des acides gras, dont la cohorte présentait un taux de mortalité coronarienne 5 fois plus grand que celui de la cohorte crétoise. En outre, l

  6. Il corpo emotivo e poetico: l'insegnamento della Bioenergetica per la formazione dell'attore

    Directory of Open Access Journals (Sweden)

    Stefano Masotti

    2012-01-01

    , contrapposto ad un teatro dell'Io, che egemonizza, enfatizzandolo, il potere della parola, della ragione e degli intelletti. Abstract – FR Un chemin expérimental d'apprendissement de la Bioénergétique dans la Scuola di Teatro di Bologna A. Galante Garrone donne l'opportunité pour réfléchir à propos de la crédibilité de l'acteur contemporain et de la mise en œuvre des psychothérapies à médiation corporelle, bien suivant de différentes finalités, dans la formation des acteurs. Les corps de nombreux entre eux sont agiles et élastiques, ils semblent vitales et élégants, encore leur attitude paraît sans sentiment.. La structure psycho-somatique du caractère représente le meilleur compromis dont le sujet est capable, pendant les premières années de son existence, dans le conflit entre ses besoins instinctuels et les demandes culturelles qui agissent par ses parents. Les expériences vécues dans le développement se sont structurées dans le corps, souvent tout en conditionant, par des contractions musculaires chroniques d'entières régions, une expréssion libre et creative du Soi. Chaque ensemble de tensions musculaires représente un conflit emotif résous par l'inhibition de certaines impulsions, qui comporte l'oubli de la fonction perceptive et un engagement excessif dans le pouvoir de l'intellect. Dans la formation de l'acteur on peut travailler beaucoup, à côté des techniques particulières, pour baisser ces “effects invalitants”, tout en suivant l'élève dans la re-conquête d'un contact avec ses émotions, à pro-mouvoir l'action en scène. L'équilibre entre l'expérience interiéure et l'expréssion évidente paraît le facteur le plus significative du travail sur soi que le theâtre peut engendrer. A ce niveau, la théorie et la technique bioénergétique peuvent contribuer, tout en aidant à ressentir les blocages, à les comprendre, à les baisser et à reduire le risque d'une narration toujours égale à soi-même. On répond, ainsi

  7. Lewis血型系统抗体的研究%Analysis of Lewis antigen system antibody

    Institute of Scientific and Technical Information of China (English)

    张烨; 刘素芳; 张磊; 庄光艳; 许志远; 闫芳

    2015-01-01

    目的 探讨Lewis血型系统抗体对于输血前检查的影响.方法 对医院送检的抗体筛选阳性、交叉配血不合的血标本做抗体鉴定.ABO定型采用试管法;试管法盐水介质和Liss/Coombs卡做抗体鉴定和交叉配血;同时鉴定Lewis血型.结果 确认84例标本均为Lewis血型抗体,Lewis血型均为Le(a-b-);其中抗-Le8阳性标本74例,抗-Leb阳性标本8例,抗-Lea+Leb阳性标本2例.抗体筛选和鉴定试验,仅在盐水介质中抗体阳性24例,仅在Liss/Coombs卡抗体阳性14例,试管法和Liss/Coombs卡抗体均阳性46例.10例标本试管法ABO血型鉴定中干扰血型反定型.结论 产生Lewis血型抗体的个体血型均为Le(a-b-);Lewis血型抗体可与ABO反定型试剂红细胞发生反应干扰ABO血型定型;盐水介质和抗人球蛋白介质抗体筛选并举可避免Lewis血型系统抗体的漏检.

  8. Using IRS Products to Recover 7ETM+ Defective Images

    Directory of Open Access Journals (Sweden)

    Mobasheri M. Reza

    2008-01-01

    Full Text Available On May 31st, 2003, Landsat 7 faced an anomaly in the Scan Line Corrector (SLC normal operation. This malfunctioning of SLC caused the individual scan lines alternately overlap each other and consequently produce large gaps at the edges of the image. Regarding the unique specification of ETM+ sensor on board of Landsat-7 satellite such as its spectral bands in the shortwave IR and TIR region and its suitable spatial resolution which is ideal for most of the scientific researches, a technique for the reconstruction of the defected images due to the SLC malfunctioning, was built up. Due to the availability of IRS/1D LISS-III images for our region of interest i.e., southwest of Iran, it was decided to use these images to recover 7ETM+ products. The procedure in reconstructing the defected 7ETM+ images is divided in to two stages. In the first stage, after implementation of some preprocessing to both LISS-III and 7ETM+, a linear regression model between bands 3 and 4 of 7ETM+ and bands 2 and 3 of LISS-III was setup. This model is used to fill up the missing places in 7ETM+ defected image and produced two new images in bands 3 and 4. In the second stage, these two newly reconstructed images of 7ETM+ were used to recover images of 7ETM+ in other spectral bands. At this stage, two methods were introduced, one using linear relationship between band 3 and bands 1 and 2 and in the second method we introduced a planar relationship between bands 3 and 4 with each one of bands 5, 6 and 7. The models are applied to few images and are found to be fairly reliable. The primary and necessary conditions for applying these methods have been explained in detail.

  9. Role of remote sensing in the evaluation of anthropogenic activity and its effect on environment and human econonomic development: an Indian example

    Science.gov (United States)

    Perni, Venkateswarlu

    In the scenario of a exponential growth of world population, changes in land use and evaluating the domestication and rearing of aquatic animals and plants; Remote Sensing has the role of an emerging discipline and provides essential tools of trade to the environmental scientist. Ecologically sustainable development of the aqua resources requires that management and use as compatible with the attributes of exploited resources. Aquaculture plays a crucial role in the development of fishing industry and contributes in rural development, increased foreign reserves besides replenishment of important aquatic species. The synoptivity, repititivity and multi spectral vision are the significant edges of Remote Sensing over conventional practices in the application domain. The present study aimed at mapping and monitoring of damages to the ecologically sensitive land farms like mangroves, sand deserts, wetlands, marshy areas etc., due to the development of aquaculture ponds and to analyze and understand the impact of pond aquaculture on water course, ground water quality, drinking water source etc. Indian Remote Sensing satellite:1D - Liss-III + PAN sensors merged data of two seasons is used to carry out change detection studies of mangroves, lakes/lagoons and coastal wetlands. To generate microscopic information of Machilipatnam and to monitor the water circulation in creeks the very high resolution IKONOS Panchromatic data is used. Geometrically rectified digital base map covering the study area is prepared on 1:63,630 scale. Satellite data of Land Sat TM, IRS Liss - II, Liss - III and PAN were used. Satellite data geometrically rectified with reference to base map using standard image-to-image tie up procedure besides necessary enhancement techniques for better interpretation. The economic impact of aquaculture is critically analyzed considering certain statistics and the resultant affects are presented. Tropical brackish water and saltwater aquaculture have contributed

  10. Understanding the role of asymmetric cell division in cancer using C. elegans.

    Science.gov (United States)

    Hyenne, Vincent; Chartier, Nicolas T; Labbé, Jean-Claude

    2010-05-01

    Asymmetric cell division is an important process to generate cell diversity and maintain tissue homeostasis. Recent evidence suggests that this process may also be crucial to prevent tumor formation. In the past 30 years, the embryo of the nematode Caenorhabditis elegans has proven to be a very powerful model to study the molecular and cellular basis of asymmetric cell division. Understanding this process in Caenorhabditis elegans may thus lead to a better understanding of stem cell function and tumorigenesis in humans. Copyright (c) 2010 Wiley-Liss, Inc.

  11. Cohomologie non ramifi\\'ee en degr\\'e trois d'une vari\\'et\\'e de Severi-Brauer

    CERN Document Server

    Pirutka, Alena

    2011-01-01

    Soit K le corps des fractions d'une surface projective et lisse, g\\'eom\\'etriquement int\\`egre, d\\'efinie sur un corps fini F. Soit C/K une conique. Parimala et Suresh ont montr\\'e que le groupe de cohomologie non ramifi\\'ee en degr\\'e trois de K(C) \\`a coefficients de torsion est nul. Dans cette note on \\'etend leur r\\'esultat aux vari\\'et\\'es de Severi-Brauer associ\\'ees \\`a une alg\\`ebre centrale simple dont d'indice l est premier et diff\\'erent de char F.

  12. Nutritional status at diagnosis in children and adolescents with cancer in the Asociacion de Hemato-Oncologia Pediatrica de Centro America (AHOPCA) countries: preliminary results from Guatemala.

    Science.gov (United States)

    Sala, Alessandra; Rossi, Emanuela; Antillon, Federico

    2008-02-01

    More than 50% of children with cancer in Guatemala have some degree of malnutrition at diagnosis. In particular, the proportions of patients with non-lymphoblastic leukemias and myelodysplasia (MDS) with moderate and severe malnutrition were 73% and 9% respectively; higher than that in the population with acute lymphoblastic leukemia (ALL), P = 0.0493. There was no relationship of nutritional status to gender. Children with ALL and other leukemias + MDS who had severe malnutrition were significantly younger than such malnourished children with solid tumors (P = 0.0003). The relationship of malnutrition to race was mixed, perhaps reflecting the frequent difficulty of accurately categorizing race. (c) 2007 Wiley-Liss, Inc.

  13. Congenital and acquired neutropenia consensus guidelines on diagnosis from the Neutropenia Committee of the Marrow Failure Syndrome Group of the AIEOP (Associazione Italiana Emato-Oncologia Pediatrica).

    Science.gov (United States)

    Fioredda, Francesca; Calvillo, Michaela; Bonanomi, Sonia; Coliva, Tiziana; Tucci, Fabio; Farruggia, Piero; Pillon, Marta; Martire, Baldassarre; Ghilardi, Roberta; Ramenghi, Ugo; Renga, Daniela; Menna, Giuseppe; Barone, Angelica; Lanciotti, Marina; Dufour, Carlo

    2011-07-15

    Congenital and acquired neutropenia are rare disorders whose frequency in pediatric age may be underestimated due to remarkable differences in definition or misdiagnosed because of the lack of common practice guidelines. Neutropenia Committee of the Marrow Failure Syndrome Group (MFSG) of the AIEOP (Associazione Italiana Emato-Oncologia Pediatrica) elaborated this document following design and methodology formerly approved by the AIEOP board. The panel of experts reviewed the literature on the topic and participated in a conference producing a document which includes a classification of neutropenia and a comprehensive guideline on diagnosis of neutropenia. Copyright © 2011 Wiley-Liss, Inc.

  14. Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology.

    Science.gov (United States)

    Toussaint, Olivier; Weemaels, Geoffroy; Debacq-Chainiaux, Florence; Scharffetter-Kochanek, Karin; Wlaschek, Meinhard

    2011-02-01

    In life sciences, modelling of the in vivo conditions using in vitro models is an important tool to generate knowledge. Although aerobic organisms including mammals depend on accurate oxygen tension, mimicking physiological conditions in cell culture experiments is not very common. Due to the need for simple technical and experimental design, the requirement for simulating the in vivo oxygen tension parameters has been neglected over long time. Fortunately, due to increasing knowledge in recent years the attention has shifted towards this scientific demand. In this short review, we summarize data substantiating the necessity to adequately mimic physiological oxygen tension using cell culture models in life science research. © 2010 Wiley-Liss, Inc.

  15. Anatomy that must be taught to a medical undergraduate: an interview-based survey in an Indian medical school.

    Science.gov (United States)

    Nayak, Satheesha; Ramnarayan, K; Somayaji, S N

    2005-07-01

    Confusion still exists about the anatomy to be taught to the medical undergraduate. We did an interview-based survey at the Melaka Manipal Medical College in Manipal, India, to try to evaluate the quantum of anatomy that should be taught to the medical undergraduate. The results suggest that excluding trivia and making anatomy more clinically oriented would be advantageous. A hybrid approach to anatomy including both problem-based learning and discipline-based curricula would be a better option than the regional or systemic approaches. Copyright 2005 Wiley-Liss, Inc.

  16. The behavioral phenotype of the Angelman syndrome.

    Science.gov (United States)

    Williams, Charles A

    2010-11-15

    The Angelman syndrome is clinically delineated by the combination of seizures, absent speech, hypermotoric and ataxic movements and certain remarkable behaviors. Those with the syndrome have a predisposition toward apparent happiness and paroxysms of laughter, and this finding helps distinguish Angelman syndrome from other ones involving severe developmental handicap. In this review the core neurological features of the syndrome are discussed with a focus on those behaviors that make Angelman syndrome a prototypical genetic disorder expressing a behavioral phenotype. © 2010 Wiley-Liss, Inc.

  17. Expeditious synthesis and chromatographic resolution of (+)- and (-)-trans-1-benzylcyclohexan-1,2-diamine hydrochlorides.

    Science.gov (United States)

    Bisel, P; Schlauch, M; Weckert, E; Sin, K; Frahm, A

    2001-02-01

    The hitherto unknown (-)- and (+)-1-benzylcyclohexan-1,2-diamine hydrochlorides 4a. HCl and 4b. HCl were synthesized by means of diastereoselective alpha-iminoamine rearrangement with subsequent imine reduction and hydrogenolysis. The relative trans-configuration as well as the absolute (1S,2R) and (1R,2S) configurations of 4a and 4b, respectively, were elucidated on the basis of an X-ray analysis of 3b. HCl. The enantiomeric excess (ee) values of the title compounds (>99%) were determined by chiral HPLC on a Chirex (D) Penicillamine column. Copyright 2001 Wiley-Liss, Inc.

  18. Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample

    DEFF Research Database (Denmark)

    Tesli, Martin; Athanasiu, Lavinia; Mattingsdal, Morten

    2010-01-01

    A recent genome-wide association study (GWAS) found significant association between the PALB2 SNP rs420259 and bipolar disorder (BD). The intracellular functions of the expressed proteins from the breast cancer risk genes PALB2 and BRCA2 are closely related. Therefore, we investigated the relatio...... in our Scandinavian sample (n¿=¿781/2,839). Our findings support PALB2 and BRCA2 as risk genes specifically for BD, and suggest that altered DNA repair related to neurogenesis may be involved in BD pathophysiology. © 2010 Wiley-Liss, Inc....

  19. "Just" in time: gene theory and the biology of the cell surface.

    Science.gov (United States)

    Sapp, Jan

    2009-10-01

    Ernest Everett Just's critique of gene theory, his emphasis on the importance of cell cytoplasm, especially of the cortex in development and heredity, is placed within the context of his times, when the views of embryologists, who emphasized heredity as process, and those of geneticists who held determinist conceptions of the gene, were irreconcilable. Just's emphasis on the cell cortex in heredity and morphogenesis was appreciated by few, but was vindicated by studies of cortical inheritance and the morphogenetic role of pre-existing cell structure in ciliated protists. His essential criticisms of mechanism remain potent today. (c) 2009 Wiley-Liss, Inc.

  20. Retraction: Genistein protects genioglossus myocyte against hypoxia-induced injury through PI3K-Akt and ERK MAPK pathways.

    Science.gov (United States)

    2012-05-01

    RETRACTION: The following article from Journal of Cellular Biochemistry, Genistein protects genioglossus myocyte against hypoxia-induced injury through PI3K-Akt and ERK MAPK pathways by Wanghui Ding and Yuehua Liu, posted online on May 19, 2011 in Wiley Online Library (onlinelibrary.wiley.com), has been retracted by agreement between the authors, the journal Editor in Chief, Dr. Gary S. Stein and Wiley-Liss, Inc. The retraction has been made as authorization to publish was not granted by one of the funding bodies.

  1. Demarcation of coastal vulnerability line along the Indian coast

    Digital Repository Service at National Institute of Oceanography (India)

    Ajai; Baba, M.; Unnikrishnan, A.S.; Rajawat, A.S.; Bhattacharya, S.; Ratheesh, R.; Kurian, N.P.; Hameed, S.; Sundar, D.

    study areas by Survey of India through detailed filed surveys. Digital Elevation Model (DEM) has been generated using this data for all the three test sites using ERDAS Image processing s/w. Resourcesat-1 LISS-IV image has been draped over the DEM..., India 2Centre for Earth Science Studies, Thiruvananthapuram - 695 031, India 3National Institute of Oceanography, Dona Paula - 403 004, India Email: ajai@sac.isro.gov.in (Received: February 12, 2012; in final form March 21, 2013) Journal of Geomatics...

  2. The behaviour of aluminium in waters of the Mandovi estuary, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Upadhyay, S.; SenGupta, R.

    (1995) 261-276 The behaviour of aluminium in waters of the Mandovi estuary, west coast of India S. Upadhyay aY1, R. Sen Gupta b a Department of Marine Science, Goa University. Goa 403203. India b National Institute of Oceanography, Dona Paula, Goa...- tems (Plankey and Patterson, 1987), only a few ’ Present address: School of Environmental Sciences, Univer- sity of East Anglia, Norwich, NR4 7TJ, UK. studies are available concerning its behaviour in estuaries (Hosokawa et al., 1970; Hydes and Liss...

  3. Pulmonary toxocariasis masquerading as metastatic tumor nodules in a child with osteosarcoma.

    Science.gov (United States)

    Lim, Yeon-Jung; Kim, Ji-Hye; Oh, Sung Hee; Jeon, Seok Chul; Koh, Hyun Chul; Lee, Young-Ho

    2009-12-15

    A 14-year-old male, who completed chemotherapy following limb salvage surgery for osteosarcoma approximately 2 years ago, was seen for routine follow-up. A CT scan revealed new scattered multifocal nodular lesions. An ultrasonography-guided percutaneous needle biopsy was done to confirm pulmonary metastasis of the underlying osteosarcoma. The lung biopsy showed findings of eosinophilic pneumonia with no evidence of malignancy. Peripheral eosinophilia was also noted. When a more thorough history revealed frequent intake of raw cow liver, we diagnosed pulmonary toxocariasis by ELISA for specific serum IgG antibody. (c) 2009 Wiley-Liss, Inc.

  4. Vertebrate intestinal endoderm development.

    Science.gov (United States)

    Spence, Jason R; Lauf, Ryan; Shroyer, Noah F

    2011-03-01

    The endoderm gives rise to the lining of the esophagus, stomach and intestines, as well as associated organs. To generate a functional intestine, a series of highly orchestrated developmental processes must occur. In this review, we attempt to cover major events during intestinal development from gastrulation to birth, including endoderm formation, gut tube growth and patterning, intestinal morphogenesis, epithelial reorganization, villus emergence, as well as proliferation and cytodifferentiation. Our discussion includes morphological and anatomical changes during intestinal development as well as molecular mechanisms regulating these processes. Copyright © 2011 Wiley-Liss, Inc.

  5. Vincristine sulfate liposomal injection for acute lymphoblastic leukemia [Corrigendum

    Directory of Open Access Journals (Sweden)

    Soosay Raj TA

    2013-12-01

    Full Text Available Soosay Raj TA, Smith AM, Moore AS. Int J Nanomedicine. 2013;8:4361–4369.On page 4366, Table 1, Notes,Notes: Reproduced with permission of Wiley and Sons. Moore A, Pinkerton R. Vincristine: can its therapeutic index be enhanced? Pediatr Blood Cancer. 2009;53(7:1180–1187.22Should readNotes: Copyright © 2009, Wiley-Liss Inc. This material is reproduced with permission of John Wiley and Sons, Inc. Moore A, Pinkerton R. Vincristine: can its therapeutic index be enhanced? Pediatr Blood Cancer. 2009;53(7:1180–1187.22Read the original article

  6. Palvelun laadun kehittäminen lentokenttäkahvilassa : SSP Finland Oy ketteräksi organisaatioksi

    OpenAIRE

    Halvorsen, Henrietta

    2013-01-01

    Restonomi YAMK-tutkintoon sisältyvä opinnäytetyöni sijoittuu kahvilapisteeseen Helsinki-Vantaan lentoasemalle. Lentoasemalla toimiva Select Service Partner Finland Oy vastaa aseman ravintola-, kahvila- ja loungepalveluista. Kansainvälisen yrityksen palveluksessa on Suomessa noin 300 työntekijää. Kehittämistehtäväni on tehty yhteen yrityksen toimipisteistä, Cafe Toriin. Kahvila on avattu kesällä 2010 ja se toimii lentoasemalla porttien 25 – 27 välissä. Kehittämistehtävän lähtökohtana on yrityk...

  7. Coprophagy by wild ring-tailed lemurs (Lemur catta) in human-disturbed locations adjacent to the Beza Mahafaly Special Reserve, Madagascar.

    Science.gov (United States)

    Fish, Krista D; Sauther, Michelle L; Loudon, James E; Cuozzo, Frank P

    2007-06-01

    Coprophagy occurs in a number of animal species, including nonhuman primates. During the 2003-2004 dry seasons at the Beza Mahafaly Special Reserve, Madagascar, we observed wild ring-tailed lemurs (Lemur catta) consuming dried fecal matter from three different species. Ring-tailed lemurs consumed human feces on 12 occasions, cattle feces twice, and feral dog feces once. Coprophagy in this population may be a behavioral adaptation that provides animals access to energy and nutrients and may be an important nutritional source for older, and/or dentally impaired individuals during the dry season. (c) 2007 Wiley-Liss, Inc.

  8. Large deletion of the GJB6 gene in deaf patients heterozygous for the GJB2 gene mutation: genotypic and phenotypic analysis.

    Science.gov (United States)

    Feldmann, Delphine; Denoyelle, Françoise; Chauvin, Pierre; Garabédian, Eréa-Noël; Couderc, Rémy; Odent, Sylvie; Joannard, Alain; Schmerber, Sébastien; Delobel, Bruno; Leman, Jacques; Journel, Hubert; Catros, Hélène; Le Maréchal, Cédric; Dollfus, Hélène; Eliot, Marie-Madeleine; Delaunoy, Jean-Pierre; David, Albert; Calais, Catherine; Drouin-Garraud, Valérie; Obstoy, Marie-Françoise; Bouccara, Didier; Sterkers, Olivier; Huy, Patrice Tran Ba; Goizet, Cyril; Duriez, Françoise; Fellmann, Florence; Hélias, Jocelyne; Vigneron, Jacqueline; Montaut, Bétina; Lewin, Patricia; Petit, Christine; Marlin, Sandrine

    2004-06-15

    Recent investigations identified a large deletion of the GJB6 gene in trans to a mutation of GJB2 in deaf patients. We looked for GJB2 mutations and GJB6 deletions in 255 French patients presenting with a phenotype compatible with DFNB1. 32% of the patients had biallelic GJB2 mutations and 6% were a heterozygous for a GJB2 mutation and a GJB6 deletion. Biallelic GJB2 mutations and combined GJB2/GJB6 anomalies were more frequent in profoundly deaf children. Based on these results, we are now assessing GJB6 deletion status in cases of prelingual hearing loss. Copyright 2004 Wiley-Liss, Inc.

  9. Genetic screening for Krabbe disease: learning from the past and looking to the future.

    Science.gov (United States)

    Macarov, Michal; Zlotogora, Joel; Meiner, Vardiella; Khatib, Zinab; Sury, Vivi; Mengistu, Getu; Bargal, Ruth; Shmueli, Esther; Meidan, Bela; Zeigler, Marsha

    2011-03-01

    In Israel, Krabbe disease is frequent in two Moslem Arab villages in the Jerusalem area. In this paper we present our experience of almost four decades with diagnosis of Krabbe disease, carrier screening and prenatal diagnosis. The screening program is well accepted by the community, and there is a clear trend towards premarital testing. The screening program and prenatal diagnosis have led to a decrease in the incidence of Krabbe disease from 1.6 per 1,000 live births to 0.82 per 1,000. Copyright © 2011 Wiley-Liss, Inc.

  10. Latissimus dorsi muscle-flap over Gore-Tex patch for coverage of large thoracic defects in paediatric Ewing sarcoma.

    Science.gov (United States)

    Gapany, Christophe; Raffoul, Wassim; Zambelli, Pierre-Yves; Joseph, Jean-Marc

    2009-05-01

    Primary rib involvement accounts for 16% of paediatric Ewing sarcoma (ES). Neo-adjuvant chemotherapy and surgical tumor resection may leave large thoracic wall defects requiring complex reconstruction in a growing individual. We report our experience in three children aged 3, 10, and 12 years, in whom single-stage resection and reconstruction were performed using a Gore-Tex Dualmesh patch, covered by a latissimus dorsi rotation flap harvested in continuity with the thoracolumbar fascia. The youngest patient also had a vertical expandable prosthetic titanium rib (VEPTR) anchored to help prevent subsequent scoliosis throughout growth. (c) 2009 Wiley-Liss, Inc.

  11. Cutting balloon angioplasty for undilatable venous stenoses causing dialysis graft failure.

    Science.gov (United States)

    Bittl, John A; Feldman, Robert L

    2003-04-01

    Dialysis fistulas and bridge grafts frequently develop outflow stenoses in the venous limb, leading to graft failure. The venous stenoses are fibrotic and require percutaneous transluminal angioplasty with high-pressure balloons. We have encountered venous stenoses in 3 out of 219 hemodialysis patients with graft failure that were undilatable with 6-8 mm high-pressure balloons inflated to more than 24 atm. In each of these cases, treatment with a 4 mm cutting balloon successfully facilitated subsequent balloon dilation at lower pressures. Copyright 2003 Wiley-Liss, Inc.

  12. Cytological diagnosis of actinomycosis and eumycetoma: a report of two cases.

    Science.gov (United States)

    Hemalata, Mahantappa; Prasad, Sruthi; Venkatesh, Kusuma; Niveditha, S R; Kumar, Suja Ajoy

    2010-12-01

    Mycetoma and actinomycosis are common in tropical countries and are increasingly diagnosed in other parts of the world due to rapid mobilization of the population. They are usually diagnosed on histopathology. There is very limited data on the role of fine-needle aspiration cytology (FNAC) in diagnosing these lesions. We report here two cases: one of eumycetoma and the other of an actinomycosis that were reliably diagnosed with FNAC. The cytological features were similar to histopathology features and differentiated eumycetoma and actinomycosis. FNAC is a rapid, simple and inexpensive outpatient procedure that helps in rapid diagnosis. © 2010 Wiley-Liss, Inc.

  13. The integration of Darwinism and evolutionary morphology: Alexej Nikolajevich Sewertzoff (1866-1936) and the developmental basis of evolutionary change.

    Science.gov (United States)

    Levit, George S; Hossfeld, Uwe; Olsson, Lennart

    2004-07-15

    The growth of evolutionary morphology in the late 19th and early 20th centuries was inspired by the work of Carl Gegenbaur (1826-1903) and his protégé and friend Ernst Haeckel (1834-1919). However, neither of them succeeded in creating and applying a strictly Darwinian (selectionist) methodology. This task was left to the next generation of evolutionary morphologists. In this paper we present a relatively unknown researcher, Alexej Nikolajevich Sewertzoff (1866-1936) who made important contributions towards a synthesis of Darwinism and evolutionary morphology. Copyright 2004 Wiley-Liss, Inc.

  14. Molecular Haeckel.

    Science.gov (United States)

    Elinson, Richard P; Kezmoh, Lorren

    2010-07-01

    More than a century ago, Ernst Haeckel created embryo drawings to illustrate the morphological similarity of vertebrate early embryos. These drawings have been both widely presented and frequently criticized. At the same time that the idea of morphological similarity was recently attacked, there has been a growing realization of molecular similarities in the development of tissues and organs. We have surveyed genes expressed in vertebrate embryos, and we have used them to construct drawings that we call Molecular Haeckels. The Molecular Haeckels emphasize that, based on gene expression, there is a greater similarity among vertebrate embryos than even Haeckel might have imagined. (c) 2010 Wiley-Liss, Inc.

  15. Ameloblastic fibrosarcoma: a cytologist's perspective.

    Science.gov (United States)

    Gupta, Nalini; Barwad, Adarsh; Kumar, Rajiv; Rijuneeta; Vaiphei, Kim

    2011-08-01

    Fine-needle aspiration cytology of a case of ameloblastic fibrosarcoma (AFS), an unusual odontogenic tumor related to ameloblastoma (AB), was performed in a 25-year-old female with a 1 cm swelling in the left lower orbital region along with involvement of zygomatic region. Aspiration of the tumor yielded a cellular sample composed predominantly of mesenchymal element and few clusters representing epithelial component showing tall columnar cells with peripheral palisading. Detailed cytomorphological features of AFS are discussed along with differential diagnosis from other tumors such as AB, desmoplastic AB, odontogenic fibroma, ameloblastic fibrodentinoma and ameloblastic fibro-odontoma, ameloblastic fibroma. Copyright © 2010 Wiley-Liss, Inc.

  16. Congenital cytomegalovirus infection and Wiskott-Aldrich syndrome successfully treated with unrelated cord blood transplantation.

    Science.gov (United States)

    Almagor, Yotam; Revel-Vilk, Shoshana; Averbuch, Diana; Mechoulam, Hadas; Engelhard, Dan; Resnick, Igor B; Weintraub, Michael; Stepensky, Polina

    2011-10-01

    We report a successful umbilical cord blood transplantation (UCBT) in an 8-month male with Wiskott-Aldrich syndrome (WAS) and congenital cytomegalovirus (CMV) infection. The child presented at 3 months of age with symptomatic thrombocytopenia and CMV infection. Despite appropriate antiviral treatment no rise in the platelet count was observed. Genetic analysis confirmed the diagnosis of WAS. The clinical course was complicated by severe CMV retinitis with bilateral retinal hemorrhages and renal vasculitis. He underwent unrelated UCBT resulting in a rapid resolution of autoimmunity and thrombocytopenia. Copyright © 2011 Wiley-Liss, Inc.

  17. A rare case of GATA1 negative chemoresistant acute megakaryocytic leukemia in an 8-month-old infant with trisomy 21.

    Science.gov (United States)

    Stepensky, Polina; Brooks, Rebecca; Waldman, Elisha; Revel-Vilk, Shoshana; Izraeli, Shai; Resnick, Igor; Weintraub, Michael

    2010-07-01

    Children with Down syndrome (DS) have a unique form of acute megakaryocytic leukemia (AMKL) characterized by the presence of mutations in the GATA1 gene leading to increased chemosensitivity and a favorable outcome. We describe an 8-month-old male with DS who was diagnosed with AMKL without a mutation in the GATA1 gene. The patient was treated according to the DS-AML-regimen but his disease progressed and he succumbed 9 months later. This rare case of DS AMKL without a GATA1 mutation with an unfavorable outcome suggests that GATA1 testing may play a useful role in initial stratification. Copyright 2010 Wiley-Liss, Inc.

  18. Life-threatening splenic hemorrhage in two patients with Gaucher disease.

    Science.gov (United States)

    Stone, D L; Ginns, E I; Krasnewich, D; Sidransky, E

    2000-06-01

    Massive splenomegaly is a frequent finding in patients with Gaucher disease, the most common of the sphingolipidoses. Even so, the risk for splenic rupture and intracapsular hemorrhage has not been emphasized due to the rarity of this occurrence and the fibrotic, rubbery consistency of splenic tissue in these patients. We report two adult patients with type 1 Gaucher disease who suffered life-threatening splenic bleeds that were not acutely diagnosed. Both patients ultimately required emergent splenectomies. Factors complicating the diagnosis of splenic hemorrhage in patients with Gaucher disease are discussed. Published 2000 Wiley-Liss, Inc.

  19. Quality of health in survivors of childhood acute myeloid leukemia treated with chemotherapy only: A NOPHO-AML study

    DEFF Research Database (Denmark)

    Molgaard-Hansen, Lene; Glosli, Heidi; Jahnukainen, Kirsi

    2010-01-01

    BACKGROUND: More than 60% of children with acute myeloid leukemia (AML) become long-term survivors, and approximately 50% are cured with chemotherapy only. Limited data exist about their long-term morbidity and social outcomes. The aim of the study was to compare the self-reported use of health...... services was limited. Reported health and social outcomes were comparable to those of their siblings. Many survivors were smoking which may increase the risk of late effects. Pediatr Blood Cancer © 2010 Wiley-Liss, Inc....

  20. Description de deux espèces nouvelles de Histérides et d’Athicides de Sumatra

    NARCIS (Netherlands)

    Marseul, de S.

    1884-01-01

    Long. 4 m.m., larg. 2,5 m.m. — Subelliptique, un peu atténué postérieurement, subdéprimé, noir de poix luisant, antennes et pattes brun-ferrugineux. — Tête lisse, entourée d’une strie bien marquée, droite derrière l’épistome qui est légèrement concave, sinuée de chaque côté à l’angle oculaire. — Pro

  1. Laboratory Information Systems.

    Science.gov (United States)

    Henricks, Walter H

    2015-06-01

    Laboratory information systems (LISs) supply mission-critical capabilities for the vast array of information-processing needs of modern laboratories. LIS architectures include mainframe, client-server, and thin client configurations. The LIS database software manages a laboratory's data. LIS dictionaries are database tables that a laboratory uses to tailor an LIS to the unique needs of that laboratory. Anatomic pathology LIS (APLIS) functions play key roles throughout the pathology workflow, and laboratories rely on LIS management reports to monitor operations. This article describes the structure and functions of APLISs, with emphasis on their roles in laboratory operations and their relevance to pathologists.

  2. Symmetrical enchondromatosis is associated with duplication of 12p11.23 to 12p11.22 including PTHLH.

    Science.gov (United States)

    Collinson, Morag; Leonard, Samantha J; Charlton, Jocelyn; Crolla, John A; Silve, Caroline; Hall, Christine M; Oglivie, Colin; James, Margaret A; Smithson, Sarah F

    2010-12-01

    We describe a patient with striking generalized symmetrical enchondromatosis of the tubular bones and a de novo duplication of chromosome 12p11.23 to 12p11.22. The PTHLH gene within this region encodes a ligand for PTHR1: mutations in the gene encoding this receptor are associated with some cases of Ollier disease, several skeletal dysplasias including Blomstrand, Eiken, and Jansen and down-regulation of PTHLH expression in brachydactyly type E. Our findings suggest that abnormal PTHLH-PTHR1 signaling may underly this unusual form of enchondromatosis and indicate that unlike most cases of Ollier disease it is dominantly inherited. © 2010 Wiley-Liss, Inc.

  3. Morphological and crystallographic evolution of bainite transformation in Fe-0.15C binary alloy.

    Science.gov (United States)

    Zhang, Di; Terasaki, Hidenori; Komizo, Yuichi

    2010-01-01

    In this article, an in situ observation method, combining laser scanning confocal microscopy and electron backscattering diffraction, was used to investigate the morphological and crystallographic evolution of bainite transformation in a Fe-0.15C binary alloy. The nucleation at a grain boundary and inclusions, sympathetic nucleation, and impingement event of bainitic ferrite were directly shown in real time. The variant evolution during bainite transformation and misorientation between bainitic ferrites were clarified. Strong variant selection was observed during sympathetic nucleation. (c) 2009 Wiley-Liss, Inc.

  4. Successful treatment of recurrent vulvar intraepithelial neoplasia resistant to interferon and isotretinoin with cidofovir.

    Science.gov (United States)

    Koonsaeng, S; Verschraegen, C; Freedman, R; Bossens, M; Kudelka, A; Kavanagh, J; Sittisomwong, T; DeClercq, E; Snoeck, R

    2001-06-01

    Vulvar intraepithelial neoplasias are difficult to eradicate completely without extensive surgical intervention. Cidofovir, a deoxycytidine monophosphate analog, may have a therapeutic role in this disease. A 43-year-old woman with a 20-year history of genital warts presented with extensive vulvar intraepithelial neoplasia III, and refused surgical resection. Topical cidofovir 1% in Beeler base completely eradicated the lesion. Successive treatment applications, however, were necessary. Cidofovir is a promising topical antiviral compound for HPV induced vulvar intraepithelial neoplasia. Copyright 2001 Wiley-Liss, Inc.

  5. 不同内固定器固定股骨髁上骨折的生物力学比较%Biomechanical study of different internal fixations in the treatment of supracondylar femoral fractures

    Institute of Scientific and Technical Information of China (English)

    杨青; 郭卫春; 刘洋; 谭俊峰; 张觅; 李明辉; 张红旗

    2015-01-01

      结果与结论:在实验载荷条件下,逆行交锁髓内钉组和LISS钢板组骨折断端和钉道周围应力均随着轴向载荷和扭转载荷的增大而增大。在同一轴向载荷下,逆行交锁髓内钉组较LISS钢板组在6个测试应变点应变值大(P OBJECTIVE:To compare the biomechanical properties of two fixations in the treatment of supracondylar femoral fractures, explore the stress distribution differences of two fixations for supracondylar femoral fractures, and provide clinical basis for the selection of ideal fixation. METHODS:Twelve sets of adult cadaveric femoral bone were selected, and the supracondylar femoral bone was sawn with an electric saw to establish supracondylar femoral fracture models. After anatomic reduction, the fracture samples were fixed with less invasive stabilization system (LISS) plates and retrograde interlocking intramedul ary nails, respectively. Six strain gages were mounted near the fracture plane and pin track, then the fracture models were placed in the Zwick Z100 electronic universal material test machine and torisional testing machine (RNJ-500), receiving a linear load of 0-400 N and a torisional load of 0-20 N·m. Local stresses were detected, and their distributions under the same load in the two fixations were also measured. RESULTS AND CONCLUSION:In the experimental loading condition, the stress at the fracture end and around the pin track increased with the increase of the load both in the LISS plate groups and retrograde interlocking intramedul ary nail groups. In the same linear loading, the strain value at six testing points in the retrograde interlocking intramedul ary nail groups was higher than that in the LISS plate groups (P<0.01);in the same torsional loading, the LISS plate groups showed high strain value than the retrograde interlocking intramedul ary nail groups in the six test points (P<0.01). Retrograde interlocking intramedul ary nails can obviously reduce stress

  6. Convolution kernel design and efficient algorithm for sampling density correction.

    Science.gov (United States)

    Johnson, Kenneth O; Pipe, James G

    2009-02-01

    Sampling density compensation is an important step in non-cartesian image reconstruction. One of the common techniques to determine weights that compensate for differences in sampling density involves a convolution. A new convolution kernel is designed for sampling density attempting to minimize the error in a fully reconstructed image. The resulting weights obtained using this new kernel are compared with various previous methods, showing a reduction in reconstruction error. A computationally efficient algorithm is also presented that facilitates the calculation of the convolution of finite kernels. Both the kernel and the algorithm are extended to 3D. Copyright 2009 Wiley-Liss, Inc.

  7. Domain definition and target classification for CASP6.

    Science.gov (United States)

    Tress, Michael; Tai, Chin-Hsien; Wang, Guoli; Ezkurdia, Iakes; López, Gonzalo; Valencia, Alfonso; Lee, Byungkook; Dunbrack, Roland L

    2005-01-01

    Assessment of structure predictions in CASP6 was based on single domains isolated from experimentally determined structures, which were categorized into comparative modeling, fold recognition, and new fold targets. Domain definitions were defined upon visual examination of the structures with the aid of automated domain-parsing programs. Domain categorization was determined by comparison of the target structures with those in the Protein Data Bank at the time each target expired and a variety of sequence and structure-based methods to determine potential homologous relationships. 2005 Wiley-Liss, Inc.

  8. The Effects of Topic Knowledge on Intelligibility and Lexical Segmentation in Hypokinetic and Ataxic Dysarthria.

    Science.gov (United States)

    Utianski, Rene L; Lansford, Kaitlin L; Liss, Julie M; Azuma, Tamiko

    2011-12-01

    Benefits to speech intelligibility can be achieved by enhancing a listener's ability to decipher it. However, much remains to be learned about the variables that influence the effectiveness of various listener-based manipulations. This study examined the benefit of providing listeners with the topic of some phases produced by speakers with either hypokinetic or ataxic dysarthria. Total and topic word accuracy, topic-related substitutions, and lexical boundary errors were calculated from the listener transcripts. Data were compared with those who underwent a familiarization process (reported by Liss, Spitzer, Caviness, & Adler, 2002) and with those inexperienced with disordered speech (reported by Liss Spitzer, Caviness, & Adler, 2000). Results revealed that listeners of ataxic speech provided with topic knowledge obtained higher intelligibility scores than naïve listeners. The magnitude of benefit was similar to the familiarization condition. However, topic word and word substitution analyses revealed different underlying perceptual mechanisms responsible for the observed benefit. No differences attributable to listening condition were discovered in lexical segmentation patterns. Overall, the results support the need for further study of listener-based manipulations to elucidate the mechanisms responsible for the observed perceptual benefits for each dysarthria type.

  9. ÉTUDE SUR LES CAPACITÉS DE FRANCHISSEMENT DES CABOTS BOUCHE-RONDES (SICYOPTERUS LAGOCEPHALUS, PALLAS, 1770 EN VUE DE LA CONCEPTION DE DISPOSITIFS ADAPTÉS AUX PRISES D’EAU DU TRANSFERT SALAZIE (ÎLE DE LA REUNION.

    Directory of Open Access Journals (Sweden)

    VOEGTLÉ B.

    2002-01-01

    puissent franchir un mur vertical, le pourcentage de passage et le taux de réussite est beaucoup plus faible que pour les autres pentes testées. Une pente à 50°, et une charge de l’ordre de 1-2 mm sont les deux conditions ayant permis sur le pilote d’obtenir les meilleurs résultats. Le revêtement de la rampe s’est révélé être un facteur secondaire, le béton lisse constituant cependant le meilleur support. Les résultats de cette étude ont permis de proposer des critères de dimensionnement pour des dispositifs de franchissement adaptés aux sites et à l’espèce. La passe consiste en une rampe en béton lisse installée à une pente de 50° alimentée par déversement. Une alimentation non uniforme sur la largeur de la rampe permet d’obtenir, quel que soit le niveau amont, une zone favorable à la remontée du poisson.

  10. Frequency of color blindness among Nigerian school children in Lagos.

    Science.gov (United States)

    Williams, G O; Taylor, F E; Odidika, Irene I; Amusa, K O

    1998-01-01

    Plates 1-15 of the Ishihara tests for color blindness were administered to 5,580 boys and 5,405 girls in primary and secondary schools in Lagos. The difference between males and females in the frequency of total color blindness was not significant. The frequency of total color blindness among the children was 0.19%. However, the frequencies of red-green color blindness, which were 3.60% and 0.81% among the males and females, respectively, were significantly different. Deutans occurred at a higher frequency than protans among both male and female red-green color blind individuals, but the differences among males and also females were not significant. In addition, there was no significant difference between the sexes in the occurrence of deutans and protans. Although the frequency of red-green color blindness detected among males in this study is significantly lower than that reported for Lagos in another survey, which gave a frequency similar to that for Caucasians, the frequency obtained in the present study is similar to frequencies reported for other populations of Blacks of African Ancestry. Am. J. Hum. Biol. 10:283-288, 1998. © 1998 Wiley-Liss, Inc. Copyright © 1998 Wiley-Liss, Inc.

  11. Spatio - Temporal Variation of Aerosol and its relation to vegetation cover over mega-city New Delhi

    Science.gov (United States)

    Pandey, Alok; Pravesh Kumar, Ram; Berwal, Shivesh; Kumar, Krishan; Kumar, Ritesh

    2016-07-01

    MODerate resolution Imaging Spectro-radiometer (MODIS) on board NASA's Terra and Aqua satellite Level 2 Aerosol optical depth (AOD) data is used for aerosol study and LISS III sensor on board Indian Remote Sensing (IRS) Satellite procured from the National Remote Sensing Center (NRSC), Hyderabad, India was used for vegetation cover estimation over New Delhi and its surrounding regions. Lowest AOD was found in the spring and winter season where highest AOD in summer months. Different dates representing different seasons LISS III imageries were used for generation of land-cover maps for vegetation study. The land cover maps reveal that most of the surrounding areas of Delhi are covered with vegetation in the month of March. By the month of May-June herbs are cut or dry from most of the region surrounding Delhi and the land cover in the surrounding areas changes to bare soil. During the rainy season (July to September) the vegetation cover over Delhi and the surrounding areas increases significantly. In November - December there is dispersed vegetation cover over New Delhi and its surrounding regions depending upon the age of the newly sown crop and ornamental plants. We found that, there is statistically significant negative correlation between AOD and Vegetation in every season over New Delhi.

  12. Neural network parameters affecting image classification

    Directory of Open Access Journals (Sweden)

    K.C. Tiwari

    2001-07-01

    Full Text Available The study is to assess the behaviour and impact of various neural network parameters and their effects on the classification accuracy of remotely sensed images which resulted in successful classification of an IRS-1B LISS II image of Roorkee and its surrounding areas using neural network classification techniques. The method can be applied for various defence applications, such as for the identification of enemy troop concentrations and in logistical planning in deserts by identification of suitable areas for vehicular movement. Five parameters, namely training sample size, number of hidden layers, number of hidden nodes, learning rate and momentum factor were selected. In each case, sets of values were decided based on earlier works reported. Neural network-based classifications were carried out for as many as 450 combinations of these parameters. Finally, a graphical analysis of the results obtained was carried out to understand the relationship among these parameters. A table of recommended values for these parameters for achieving 90 per cent and higher classification accuracy was generated and used in classification of an IRS-1B LISS II image. The analysis suggests the existence of an intricate relationship among these parameters and calls for a wider series of classification experiments as also a more intricate analysis of the relationships.

  13. Estimation of Leaf Area Index Using IRS Satellite Images

    Directory of Open Access Journals (Sweden)

    A Faridhosseini

    2012-12-01

    Full Text Available Estimation of vegetation cover attributes, such as the Leaf Area Index (LAI, is an important step in identifying the amount of water use for some plants. The goal of this study is to investigate the feasibility of using IRS LISS-III data to retrieve LAI. To get a LAI retrieval model based on reflectance and vegetation index, detailed field data were collected in the study area of eastern Iran. In this study, atmospheric corrected IRS LISS-III imagery was used to calculate Normalized Difference Vegetation Index (NDVI. Data of 50 samples of LAI were measured by Sun Scan System – SS1 in the study area. In situ measurements of LAI were related to widely use spectral vegetation indices (NDVI. The best model through analyzing the results was LAI = 19.305×NDVI+5.514 using the method of linear-regression analysis. The results showed that the correlation coefficient R2 was 0.534 and RMSE was 0.67. Thereby, suggesting that, when using remote sensing NDVI for LAI estimation, not only is the choice of NDVI of importance but also prior knowledge of plant architecture and soil background. Hence, some kind of landscape stratification is required before using multi- spectral imagery for large-scale mapping of vegetation biophysical variables.

  14. Selecting an acceptable and safe antibody detection test can present a dilemma.

    Science.gov (United States)

    Combs, M R; Bredehoeft, S J

    2001-01-01

    The Transfusion Service at Duke University Hospital has changed antibody detection methods from the use of albumin in indirect antiglobulin tests to low-ionic-strength solution (LISS), and from LISS to polyethylene glycol (PEG) in an effort to enhance the rapid detection of clinically significant antibodies. In 1996, staffing issues required the consideration of automation. Although previous studies indicated that the gel test was not as sensitive as PEG for detection of clinically significant antibodies, we chose to implement the gel test to be used with the Tecan MegaFlex-ID. We performed a retrospective analysis of identified antibodies and transfusion reactions to compare the outcomes of one year's experience with gel and PEG. We found comparable detection of potentially clinically significant antibodies by both methods and significantly fewer unwanted or clinically insignificant antibodies detected with the use of gel. Fewer delayed serologic transfusion reactions and no transfusion-associated hemolytic events occurred in the year that gel was used. Although we initially found the selection of the gel test to be a dilemma, our ultimate decision appears to have successfully protected patient safety and balanced sensitivity with specificity.

  15. Measures of genotoxicity in Gulf war I veterans exposed to depleted uranium.

    Science.gov (United States)

    McDiarmid, Melissa A; Albertini, Richard J; Tucker, James D; Vacek, Pamela M; Carter, Elizabeth W; Bakhmutsky, Marina V; Oliver, Marc S; Engelhardt, Susan M; Squibb, Katherine S

    2011-08-01

    Exposure to depleted uranium (DU), an alpha-emitting heavy metal, has prompted the inclusion of markers of genotoxicity in the long-term medical surveillance of a cohort of DU-exposed Gulf War veterans followed since 1994. Using urine U (uU) concentration as the measure of U body burden, the cohort has been stratified into low-u (genotoxicity [micronuclei (MN), chromosome aberrations, and MFs of HPRT and PIGA] were examined. There were no statistically significant differences in any outcome measure when results were compared between the low- vs. high-U groups. However, modeling of the HPRT MF results suggests a possible threshold effect for MFs occurring in the highest U exposed cohort members. Mutational spectral analysis of HPRT mutations is underway to clarify a potential clonal vs. a threshold uU effect to explain this observation. This study provides a comprehensive evaluation of a human population chronically exposed to DU and demonstrates a relatively weak genotoxic effect of the DU exposure. These results may explain the lack of clear epidemiologic evidence for U carcinogenicity in humans. Environ. Mol. Mutagen., 2011. © 2011 Wiley-Liss, Inc. Copyright © 2011 Wiley-Liss, Inc.

  16. Detection of IgG anti-A/B must be essential for safe transfusion support in patients undergoing ABO incompatible allogeneic HSCT.

    Science.gov (United States)

    Liu, Feng; Li, Guining; Mao, Xiaolu; Hu, Lihua

    2011-04-01

    Recipients of ABO incompatible allogeneic HSCT present with unusual ABO groups and crossmatch problems accompanied by change of the ABO group from that of the host to the donor. We report on a patient undergoing major ABO incompatible allogeneic HSCT (donor/recipient: A/O) whose blood group was wrongly established to have completely switched to blood group A when using a routine tube method and micro gel column blood grouping card on the 68th day post transplantation. The major crossmatch test with added antiglobulin and blood group A red cells was still positive. After further investigation, an explanation was found because we could not detect IgG anti-A in the serum. At the same time, anti-A coated the patient's RBCs and could be identified using a heat elution method although the DAT was negative. We also found an obvious mixed field with the LISS-IAT gel card. Hence, routine methods of ABO grouping are unfit for ABO incompatible allogeneic HSCT patients and a micro column neutral gel card is recommended for forward typing especially to detect mixed fields and a LISS-IAT gel card or IAT tube method for detecting IgG anti-A/B in reverse typing. Copyright © 2011 Elsevier Ltd. All rights reserved.

  17. Proof of shock-excited H$_2$ in low-ionization structures of PNe

    CERN Document Server

    Akras, Stavros; Ramos-Larios, Gerardo

    2016-01-01

    We report the detection of near-IR H$_2$ lines emission from low-ionization structures (LISs) in planetary nebulae. The deepest, high-angular resolution H$_2$ 1-0 S(1) at 2.122 $\\mu$m, and H$_2$ 2-1 S(1) at 2.248 $\\mu$m images of K 4-47 and NGC 7662, obtained using NIRI@Gemini-North, are presented here. K 4-47 reveals a remarkable high-collimated bipolar structure. The H$_2$ emission emanates from the walls of the bipolar outflows and a pair of knots at the tips of these outflows. The H$_2$ 1-0 S(1)/2-1 S(1) line ratio is $\\sim$7-10 which indicates shock interaction due to both the lateral expansion of the gas in the outflows and the high-velocity knots. The strongest line, H$_2$ v=1-0 S(1), is also detected in several LISs located at the periphery of the outer shell of the elliptical PN NGC 7662, whereas only four knots are detected in the H$_2$ v=2-1 S(1) line. These knots have H$_2$ v=1-0 S(1)/v=2-1 S(1) values between 2 and 3. These data confirm the presence of molecular gas in both highly (K 4-47) and sl...

  18. Prévalence des dyslipidémies au laboratoire de biochimie du CHU Aristide le Dantec de Dakar, Sénégal

    Science.gov (United States)

    Cissé, Fatou; Agne, Fatou Diallo; Diatta, Alassane; Mbengue, Abdou Salam; Ndiaye, Arame; Samba, Abdourahmane; Thiam, Souleymane; Doupa, Dominique; Sarr, Gaston Ndéné; Sall, Niama Diop; Touré, Méissa

    2016-01-01

    Introduction L'objectif de cette étude était d'évaluer la prévalence des dyslipidémies chez les patients reçus au laboratoire de Biochimie de l'Hôpital Aristide Le Dantec pour le dosage d'un paramètre lipidique au cours de l'année 2013. Méthodes Il s'agit d'une étude rétrospective portant sur 1356 patients âgés de 10 à 94 ans reçus au laboratoire de Biochimie du CHU Le Dantec de janvier à décembre 2013. Etaient inclus dans l'étude, tous les patients ayant au moins un paramètre du bilan lipidique dont les résultats étaient enregistrés dans le registre du laboratoire. Le cholestérol total, le cholestérol HDL, le cholestérol LDL ainsi que les triglycérides ont été dosés grâce à des méthodes enzymatiques sur un automate de Biochimie de type Cobas Integra 400 (Roche Diagnostics). Résultats La prévalence des dyslipidémies dans notre population d'étude est de 39,30%. Les prévalences de l'hypercholestérolémie, l'hypoHDLémie, l'hyperLDLémie, l'hypertriglycéridémie et l'hyperlipidémie mixte étaient respectivement : 30,89% ; 7,30% ; 31,19% ; 0,51% ; 7,22%. Les sujets de 40 à 59 ans semblaient être plus exposés et on note une prédominance féminine en ce qui concerne l'hypercholestérolémie (54,17% vs 45,82%), l'hypoHDLémie (54,54% vs45, 45%), et l'hyperlipidémie mixte (51,08% vs 48,97%). Enfin les dyslipidémies étaient fortement corrélées à l'HTA et l'obésité. Conclusion La forte prévalence des dyslipidémies retrouvée dans notre étude démontre l'intérêt d'étudier la prévalence des facteurs de risque cardio-vasculaires en particulier les dyslipidémies dans la population sénégalaise. PMID:28292030

  19. Douleurs induites par les soins: la réalité au Centre Hospitalier Universitaire de Befelatanana Antananarivo, Madagascar

    Science.gov (United States)

    Mahavivola, Ernestho-Ghoud Indretsy; Olivah, Razanaparany Miarisoa Mireille; Mihary, Dodo; Hendriniaina, Rakotoharivelo; Lalao, Randriamboavonjy Rado; Henintsoa, Rakotonirainy Oliva; Fahafahantsoa, Rapelanoro Rabenja

    2014-01-01

    La douleur induite par les soins correspond à la douleur survenant lors des actes à visé diagnostique et/ou thérapeutique. A notre connaissance, nous n'avons pas encore des données disponibles pour les douleurs induites par les soins à l'Hôpital de Befelatanana. Nos objectifs étaient de décrire le profil épidémiologique de la douleur induite par les soins, d'identifier les principaux facteurs influençant sur l'intensité de la douleur et leurs retentissements chez les patients. Il s'agissait d'une étude rétrospective, transversale type un jour donné menée dans les douze services de Médecines au Centre Hospitalier Universitaire de Befelatanana en Novembre 2013. Cent deux patients ont été retenus dans l’étude et trois cent vingt trois actes douloureux étaient enregistrés. La fréquence de la douleur induite par les soins était de 69,86%. Le genre féminin prédominait dans 52% des cas (n = 53) avec un sex-ratio à 0,92. L’âge moyen était de 46 ans. Les ponctions vasculaires étaient l'acte prédominant dans 49,54% (n = 109) des cas. Les infirmiers réalisaient les soins dans 47,05% (n = 48) des cas. L'information verbale était la mesure préventive utilisée dans 57,84% des cas (n = 59). Le transport par marche à pied et au dos représentait 16,67% des cas (n = 17). Les patients naïfs des gestes étaient plus anxieux. Ces patients gardaient de mauvais souvenir dans 64,71% des cas (n = 66). La fréquence de douleur induite par les soins était trop élevée. Un effort important est nécessaire pour réduire la douleur induite par les soins PMID:25932071

  20. Maladie des vibrations

    Science.gov (United States)

    Shen, Shixin (Cindy); House, Ronald A.

    2017-01-01

    Résumé Objectif Permettre aux médecins de famille de comprendre l’épidémiologie, la pathogenèse, les symptômes, le diagnostic et la prise en charge de la maladie des vibrations, une maladie professionnelle importante et courante au Canada. Sources d’information Une recherche a été effectuée sur MEDLINE afin de relever les recherches et comptes rendus portant sur la maladie des vibrations. Une recherche a été effectuée sur Google dans le but d’obtenir la littérature grise qui convient au contexte canadien. D’autres références ont été tirées des articles relevés. Message principal La maladie des vibrations est une maladie professionnelle répandue touchant les travailleurs de diverses industries qui utilisent des outils vibrants. La maladie est cependant sous-diagnostiquée au Canada. Elle compte 3 éléments : vasculaire, sous la forme d’un phénomène de Raynaud secondaire; neurosensoriel; et musculosquelettique. Aux stades les plus avancés, la maladie des vibrations entraîne une invalidité importante et une piètre qualité de vie. Son diagnostic exige une anamnèse minutieuse, en particulier des antécédents professionnels, un examen physique, des analyses de laboratoire afin d’éliminer les autres diagnostics, et la recommandation en médecine du travail aux fins d’investigations plus poussées. La prise en charge consiste à réduire l’exposition aux vibrations, éviter les températures froides, abandonner le tabac et administrer des médicaments. Conclusion Pour assurer un diagnostic rapide de la maladie des vibrations et améliorer le pronostic et la qualité de vie, les médecins de famille devraient connaître cette maladie professionnelle courante, et pouvoir obtenir les détails pertinents durant l’anamnèse, recommander les patients aux cliniques de médecine du travail et débuter les demandes d’indemnisation de manière appropriée. PMID:28292812

  1. Incorporating research technology into the clinical assessment of balance and mobility: perspectives of physiotherapists and people with stroke.

    Science.gov (United States)

    Pak, Patricia; Jawed, Hina; Tirone, Christina; Lamb, Bethany; Cott, Cheryl; Brunton, Karen; Mansfield, Avril; Inness, Elizabeth L

    2015-01-01

    Objectif : Décrire les vues des gens ayant subi une attaque et de leurs physiothérapeutes au sujet du recours à la biomécanique pour l'évaluation de l'équilibre et de la mobilité. Méthodes : Dans cette étude qualitative, on a mené des interviews semi-structurées auprès de patients ayant subi un accident vasculaire cérébral et organisé un groupe de discussion avec leurs physiothérapeutes. Pour coder les données de ces interviews et de ce groupe, on a procédé par induction ligne à ligne en se servant d'un logiciel qualitatif pour convertir les codes en thèmes. Résultats : On a jugé que les données quantitatives de cette évaluation pouvaient éclairer les patients sur les problèmes d'équilibre et de mobilité. Les physiothérapeutes ont constaté que l'évaluation confirmait le raisonnement clinique et contribuait à une appréciation précise des progrès, mais leurs opinions étaient partagées en matière d'incidence sur le choix de traitement. Les patients auraient voulu plus de communication sur le but de l'évaluation. Ils ont aussi dit que la confiance dans leurs physiothérapeutes les aidait à vaincre leurs anxiétés et que cette confiance s'acquérait par une exposition à des évaluations d'équilibre plus exigeantes. Les physiothérapeutes préconisaient l'emploi d'un système de harnais pour une intégration en toute sécurité à leur pratique de l'évaluation et de la formation en maîtrise réactive de l'équilibre. Conclusion : Et les patients et les thérapeutes attachaient de la valeur aux données quantitatives issues de l'évaluation. Quelle que soit la technologie utilisée, les patients apprécient une étroite relation physiothérapeute-patient. Une constante collaboration entre les cliniciens et les chercheurs devrait nous guider dans la conversion de la technologie en outils d'intérêt clinique.

  2. Les complications chirurgicales de la transplantation rénale à partir du donneur vivant: expérience du CHU Ibn Sina de Rabat

    Directory of Open Access Journals (Sweden)

    Intissar Haddiya

    2010-09-01

    Full Text Available INTRODUCTION: La transplantation rénale (TR est actuellement considérée comme un traitement de choix de l’insuffisance rénale chronique terminale (IRCT. Ses résultats se sont améliorés au cours des dernières années. Cependant, les complications chirurgicales demeurent graves car elles touchent un rein unique et surviennent sur un terrain fragilisé par l’insuffisance rénale et l’immunosuppression. L’objectif de ce travail est d’évaluer la fréquence des complications chirurgicales lors de l’activité de TR au CHU Ibn Sina de Rabat, et de dégager les facteurs ayant influé l’apparition de ces complications. METHODES: Étude rétrospective des patients transplantés rénaux à partir de donneurs vivants apparentés (DVA de Juin 1999 à Décembre 2008 dans notre centre hospitalo-universitaire. Nous avons recensé les caractéristiques propres au receveur, au prélèvement, au donneur ainsi qu’au greffon. Les complications chirurgicales ont été colligées ainsi que leur prise en charge et évolution. RESULTATS: Soixante sept dossiers ont été analysés avec un suivi moyen de 55 +/- 28 mois. 38 complications chirurgicales ont été recensées : sténose des artères rénales (38,7%, lymphocèle (21%, hématome (12,7%, thrombose vasculaire (7,8%, reflux vésico-urétéral (4,8%, rupture du greffon (3,2%, calcul (1 cas, éventration (1 cas, L’analyse statistique de notre série n’a pas mis en évidence de facteurs de risque significatifs semblant influer sur l’incidence des complications chirurgicales. CONCLUSION: La morbidité liée aux complications chirurgicales de la TR reste élevée nécessitant un diagnostic et un traitement adéquat afin d’éviter les répercussions sur la survie des patients et des greffons.

  3. NUTRITION 91e Congrès de l’AOCS : l’essentiel du programme nutrition (San Diego, 25-28 avril 2000

    Directory of Open Access Journals (Sweden)

    Mendy François

    2000-09-01

    Full Text Available La densité du programme de la Division Health and Nutrition rendait cette fois très difficile le suivi même partiel du programme des autres divisions. Après l’impressionnante entrée en lice des functionnal foods et des nutraceuticals en 1999, il semble que la Division Health and Nutrition ait choisi de traiter de façon approfondie des thèmes importants. Les trois thèmes choisis cette année étaient : * L’acide gamma-linolénique : 22 communications auxquelles il faut sûrement ajouter les 5 communications d’une matinée sur « lipides bioactifs et transduction des signaux ». * Acide gras mono-insaturés versus polyinsaturés dans la gestion du risque de maladies cardio-vasculaires : Que devons-nous choisir ? 6 communications seulement, mais importantes, susceptibles d’avoir un gros impact et témoignant d’un vrai malaise. Selon la remarque de M. Bieber : « si ceci continue, que nous restera-t-il à dire ? ». * Lipides et désordres psychiatrique : 7 communications sur le thème de l’influence des acides gras polyinsaturés en n-3. Enfin la Division Health and Nutrition présentait 18 communications sur le thème Nutrition and General Health, son thème habituel. Parmi celles-ci, il faut relever deux Honored Student Award Winner français : S. Bellenger-Germain de l’équipe de J.-P. Poisson à Dijon, dont nous parlerons, et B. Nay de Bordeaux-II. Ceci ne s’était jamais produit jusqu’ici surtout si l’on ajoute le Herbert J. Dutton Award décerné par la Division analytique à J.-L. Sebedio. À ces 53 communications, il faut ajouter 36 posters pour la Nutrition and Health Division, soit 89 présentations au total. Pour terminer ce tour d’horizon, il faut signaler deux conférences remarquables sur des thèmes majeurs en nutrition lipidique : * celle du Stephen S. Chang Award de B. Herslof : From drug delivery to functionnal food. A lipid story; * celle du Supelco/Nicholas Research Award de H. Sprecher : The

  4. Réaction d’isomérisation de l’oléate de méthyle et de l’alcool oléique en présence de catalyseurs bimétalliques CoSn supportés

    Directory of Open Access Journals (Sweden)

    De Oliveira K.

    2003-09-01

    Full Text Available Les composés naturels sont en majorité dans la configuration cis mais au cours de leur transformation ils peuvent facilement s’isomériser en composés trans qui pourraient être à l’origine de certaines maladies cardio-vasculaires. L’objectif de notre étude est de suivre la réaction d’isomérisation cis-trans de l’oléate de méthyle et de l’alcool oléique sous azote et hydrogène en présence de catalyseurs CoSn supportés sur alumine et préparés par différentes techniques (sol-gel ou co-imprégnation. Cette étude a montré que les catalyseurs monométalliques ne permettent pas l’isomérisation cis-trans de l’ester ou de l’alcool sous atmosphère d’azote ou d’hydrogène. En revanche, l’association du cobalt et de l’étain favorise l’isomérisation cis-trans de l’ester méthylique lorsque la réaction est réalisée en milieu hydrogénant, l’activité initiale étant très augmentée lorsque la pression d’hydrogène passe de 1 à 80 bar. La présence de cobalt métallique semble favoriser la réaction d’isomérisation, puisque les systèmes CoSn préparés par voie sol-gel et exempts d’espèces métalliques s’avèrent moins isomérisants. Toutefois, l’ajout d’étain limite la réaction d’isomérisation par recouvrement des espèces cobalt en inhibant l’adsorption et l’activation de l’hydrogène. L’alcool oléique seul est préférentiellement déshydraté en présence du système CoSn mais il peut aussi s’isomériser sous forte pression d’hydrogène.

  5. Evaluation du niveau d'activité physique dans un service Marocain d'hémodialyse chronique

    Science.gov (United States)

    Karimi, Ilham; Benabdellah, Nawal; Bentata, Yassamine; Yacoubi, Hicham; Haddiya, Intissar

    2013-01-01

    Introduction L'activité physique est souvent réduite chez le patient hémodialysé chronique. Plusieurs études ont montré l'intérêt du maintien ou de la reprise d'une activité physique sur l’état de santé des patients. Le but de notre travail est d'analyser le niveau d'activité physique chez nos patients hémodialysé chronique. Méthodes Nous avons réalisé une étude transversale au centre d'hémodialyse de l'hôpital Al Farabi d'Oujda. Nous avons évalué l'activité physique de nos patients à l'aide du Questionnaire de Baecke traduit en dialectal Marocain et adapté au contexte socioculturel Marocain. Nous avons relevé les paramètres démographiques et clinico-biologiques ainsi que le niveau d'activité physique. L'analyse statistique est réalisée par le logiciel SPSS 11.5. Résultats Notre étude a inclus 83 patients. L’âge moyen était de 47,3±13,2 ans, avec une prédominance masculine. 15,6% déclarent n'avoir aucune activité physique. 68% des patients rapportent des difficultés à effectuer des efforts physiques importants (courir, soulever un objet lourd). 16,4% des patients déclarent avoir une activité physique et sportive régulière (marche, foot-ball etc..). La diminution de l'activité physique est corrélée de façon significative à l’âge avancée, l'indice de masse corporelle bas, l'ancienneté en hémodialyse et les affections cardio-vasculaires. Conclusion Un programme d'activité physique adapté à notre population d'hémodialysés et élaboré en concertation pluridisciplinaire (cardiologues, orthopédistes, rhumatologues, kinésithérapeutes) paraît intéressant dans le cadre d'une prise en charge globale du patient hémodialysé chronique. PMID:24198881

  6. Le syndrome du canal carpien chez les patients hémodialysés chroniques

    Science.gov (United States)

    Mbarki, Houda; Akrichi, Amine; Lazrak, Amine; Maaroufi, Chakib; Midaoui, Aouatif El; Tachfouti, Nabil; Jellouli, Wafa; Arrayhani, Mohamed; Belahsen, Mohamed Faouzi; Sqalli, Tarik

    2013-01-01

    Le syndrome du canal carpien (SCC) regroupe l'ensemble des signes et symptômes liés à la compression du nerf médian dans le canal carpien. Cette manifestation de l'amylose à béta2-microglobuline est une complication fréquente de l'hémodialyse au long cours. L'objectif de ce travail est d'analyser les caractéristiques du SCC et de déterminer les facteurs liés à sa survenue chez les hémodialysés chroniques. Nous rapportons une étude transversale monocentrique, menée au 3ème trimestre de l'année 2009, portant sur les patients adultes hémodialysés chroniques au service de Néphrologie-Hémodialyse au CHU de Fès. 59 patients ont accepté de participer à l'étude. Leurs âge moyen est de 48 ± 15 ans avec un sex-ratio de 0,9. Ils bénéficient tous de l'hémodialyse intermittente à raison de 10 à 12 heures par semaine, par une membrane de dialyse en polysulfone à basse perméabilité. La durée moyenne en hémodialyse est de 83 ± 6,5 mois. La prévalence du SCC dans notre centre est de 30,5%. L'électromyogramme (EMG) a confirmé la suspicion clinique du SCC chez 11 patients et a diagnostiqué un SCC chez 8 patients asymptomatiques. La comparaison statistique entre les deux groupes de patients avec et sans SCC a démontré que la survenue de ce syndrome est liée à: l'âge actuel, l'âge avancé à la mise en hémodialyse, le sexe féminin, l'excès pondéral, et l'abord vasculaire. Le SCC est une complication fréquente de l'hémodialyse chronique. L'amélioration de la qualité de dialyse permettrait de réduire le risque de survenue du SCC. PMID:23504584

  7. Moyamoya disease and syndromes: from genetics to clinical management

    Directory of Open Access Journals (Sweden)

    Guey S

    2015-02-01

    Full Text Available Stéphanie Guey,1,3 Elisabeth Tournier-Lasserve,1,2 Dominique Hervé,1,3 Manoelle Kossorotoff4 1Inserm UMR-S1161, Université Paris 7 Denis Diderot, Sorbonne Paris Cité, Paris, France; 2AP-HP, Groupe hospitalier Lariboisière-Saint-Louis, Service de génétique neurovasculaire, Paris, France; 3Service de Neurologie, Centre de Référence des maladies Vasculaires Rares du Cerveau et de l'Œil (CERVCO, Groupe Hospitalier Saint-Louis Lariboisière-Fernand Widal, Assistance Publique-Hôpitaux de Paris, Paris, France; 4Pediatric Neurology Department, French Center for Pediatric Stroke, University Hospital Necker-Enfants Malades, AP-HP Assistance publique-Hôpitaux de Paris, Paris, France Abstract: Moyamoya angiopathy is characterized by a progressive stenosis of the terminal portion of the internal carotid arteries and the development of a network of abnormal collateral vessels. This chronic cerebral angiopathy is observed in children and adults. It mainly leads to brain ischemic events in children, and to ischemic and hemorrhagic events in adults. This is a rare condition, with a marked prevalence gradient between Asian countries and Western countries. Two main nosological entities are identified. On the one hand, moyamoya disease corresponds to isolated moyamoya angiopathy, defined as being “idiopathic” according to the Guidelines of the Research Committee on the Pathology and Treatment of Spontaneous Occlusion of the Circle of Willis. This entity is probably multifactorial and polygenic in most patients. On the other hand, moyamoya syndrome is a moyamoya angiopathy associated with an underlying condition and forms a very heterogeneous group with various clinical presentations, various modes of inheritance, and a variable penetrance of the cerebrovascular phenotype. Diagnostic and evaluation techniques rely on magnetic resonance imaging (MRI, magnetic resonance angiography (MRA conventional angiography, and cerebral hemodynamics measurements

  8. Fonctionnalité, résilience, maintenance, acides gras insaturés Un exemple : l’acide linoléique et les récepteurs du LDL-cholestérol

    Directory of Open Access Journals (Sweden)

    Mendy François

    2001-07-01

    Full Text Available Fonctionnalité, résilience, maintenance, et acides gras poly-insaturés. Il deviendra impossible dans le futur de poser le problème des apports nutritionnels conseillés sans se poser la question : Conseillés dans quel but ? Comptable, humanitaire, épanouissement individuel ? Obtenir une croissance, une reproduction, un gain de masse musculaire dans le plus court temps sont des objectifs de nutritionnistes zoo-techniciens. Dans ce système, l’objectif final est la mort programmée dans un abattoir dans le délai le plus court et le plus rentable possible. En nutrition humaine, l’objectif est d’obtenir la meilleure adaptabilité possible dans n’importe quelle situation et le plus longtemps possible. L’objectif n’est plus comme à la fin du xviiie et xixe siècle, d’obtenir une main-d’oeuvre pouvant se développer et se reproduire le plus rapidement possible, assurer un travail physique efficace au moindre coût. Peut-être est-il la transmission des connaissances anciennes, l’acquisition et la transmission de connaissances nouvelles, durant le plus lontemps possible. Pour l’homme, la définition des apports nutritionnels conseillés devrait être la définition des marges de sécurités entre les apports minimaux acceptables et les apports maximaux tolérables. Ces marges de sécurité devraient permettre d’obtenir une fonctionnalité réelle, soit la meilleure conformation récepteurs-enzymes, malgré des status génétiques variés (mutations, polymorphisme, etc., un environnement aléatoire, d’obtenir la résislience, l’adaptabilité individuelle, maximale, durant le plus longtemps possible (maintenance. Il n’existe pas d’autres possibilités de prévention des maladies conformationnelles nouvellement décrites. À titre d’exemple, les conditions d’obtention du niveau de régulation optimale du récepteur LDL, la dégradation sécrétoire de l’ApoB par le récepteur LDL sur le chemin de la s

  9. Outcome prediction in pneumonia induced ALI/ARDS by clinical features and peptide patterns of BALF determined by mass spectrometry.

    Directory of Open Access Journals (Sweden)

    Jochen Frenzel

    Full Text Available BACKGROUND: Peptide patterns of bronchoalveolar lavage fluid (BALF were assumed to reflect the complex pathology of acute lung injury (ALI/acute respiratory distress syndrome (ARDS better than clinical and inflammatory parameters and may be superior for outcome prediction. METHODOLOGY/PRINCIPAL FINDINGS: A training group of patients suffering from ALI/ARDS was compiled from equal numbers of survivors and nonsurvivors. Clinical history, ventilation parameters, Murray's lung injury severity score (Murray's LISS and interleukins in BALF were gathered. In addition, samples of bronchoalveolar lavage fluid were analyzed by means of hydrophobic chromatography and MALDI-ToF mass spectrometry (MALDI-ToF MS. Receiver operating characteristic (ROC analysis for each clinical and cytokine parameter revealed interleukin-6>interleukin-8>diabetes mellitus>Murray's LISS as the best outcome predictors. Outcome predicted on the basis of BALF levels of interleukin-6 resulted in 79.4% accuracy, 82.7% sensitivity and 76.1% specificity (area under the ROC curve, AUC, 0.853. Both clinical parameters and cytokines as well as peptide patterns determined by MALDI-ToF MS were analyzed by classification and regression tree (CART analysis and support vector machine (SVM algorithms. CART analysis including Murray's LISS, interleukin-6 and interleukin-8 in combination was correct in 78.0%. MALDI-ToF MS of BALF peptides did not reveal a single identifiable biomarker for ARDS. However, classification of patients was successfully achieved based on the entire peptide pattern analyzed using SVM. This method resulted in 90% accuracy, 93.3% sensitivity and 86.7% specificity following a 10-fold cross validation (AUC = 0.953. Subsequent validation of the optimized SVM algorithm with a test group of patients with unknown prognosis yielded 87.5% accuracy, 83.3% sensitivity and 90.0% specificity. CONCLUSIONS/SIGNIFICANCE: MALDI-ToF MS peptide patterns of BALF, evaluated by appropriate

  10. Biomechanical properties of retrograde interlocking intramedullary nail versus less invasive stabilization system plate in the repair of distal femoral fractures%逆行交锁髓内钉与微创内固定钢板修复股骨远端骨折的生物力学性能比较

    Institute of Scientific and Technical Information of China (English)

    张慧东; 王井伟; 白净

    2016-01-01

    背景:目前股骨远端骨折多采用微创内固定系统(LISS)钢板或逆行交锁髓内钉内固定治疗,但两种方法的选择尚有争议,且对其生物力学性能研究尚少。目的:比较逆行交锁髓内钉与LISS钢板置入内固定修复股骨远端骨折的生物力学稳定性。方法:取12根尸体股骨标本,均为男性,X射线摄片排除损伤、骨密度异常及骨病标本。随机分成2组,制成相同标准AO分型A3型髁上骨折模型,分别用LISS钢板和逆行交锁髓内钉内固定。观察股骨标本承受轴向压缩时的抗压刚度和载荷100,300,500 N下的位移值,以及标本承受弯曲载荷时的抗弯强度。结果与结论:①在抵抗轴向变形能力(抗压刚度)方面,LISS钢板大于逆行交锁髓内钉(P0.05);②在100,300,500 N轴向压缩载荷作用下,LISS钢板组的位移均小于逆行交锁髓内钉组(P0.05). (2) Under axial compressive loading of 100, 300 and 500 N, the displacement values of LISS plate were significantly less than those of the retrograde interlocking intramedul ary nail (P<0.05). (3) In conclusion, in the distal femoral fracture fixation, the stiffness of the retrograde interlocking intramedul ary nail is low. While the LISS plate not only has certain deformation, but also has strong rigidity with firm internal fixation, which provides excel ent biological environment for fracture healing;thus it is a reliable treatment for distal femoral fractures.

  11. Histological analysis of the alterations on cortical bone channels network after radiotherapy: A rabbit study.

    Science.gov (United States)

    Rabelo, Gustavo Davi; Beletti, Marcelo Emílio; Dechichi, Paula

    2010-10-01

    The aim of this study was to evaluate the effects of radiotherapy in cortical bone channels network. Fourteen rabbits were divided in two groups and test group received single dose of 15 Gy cobalt-60 radiation in tibia, bilaterally. The animals were sacrificed and a segment of tibia was removed and histologically processed. Histological images were taken and had their bone channels segmented and called regions of interest (ROI). Images were analyzed through developed algorithms using the SCILAB mathematical environment, getting percentage of bone matrix, ROI areas, ROI perimeters, their standard deviations and Lacunarity. The osteocytes and empty lacunae were also counted. Data were evaluated using Kolmogorov-Smirnov, Mann Whitney, and Student's t test (P lacunarity were found between groups. In conclusion, the radiotherapy causes reduction of bone matrix and modifies the morphology of bone channels network. © 2010 Wiley-Liss, Inc.

  12. Preconception care for women with diabetes and prevention of major congenital malformations.

    Science.gov (United States)

    Kitzmiller, John L; Wallerstein, Robert; Correa, Adolfo; Kwan, Saiyin

    2010-10-01

    This article provides an overview of the rationale for diabetes preconception care interventions for women with diabetes and the efficacy in reducing the excess occurrence of major congenital malformations. The problems with broad use of individualized preconception care are considered. In addition, suggestions are made for the implementation of more comprehensive interventions in the community and usual diabetes care settings, to address the multiple ongoing challenges in the prevention of structural anomalies associated with preexisting diabetes. Based on the published evidence, successful preconception care can be considered to include: achievement of individualized target standardized glycosylated hemoglobin levels, adequate nutrition, and minimizing hypoglycemia before and after discontinuing effective contraception and during the transition to early prenatal care. © 2010 Wiley-Liss, Inc.

  13. Cancer models in Caenorhabditis elegans.

    Science.gov (United States)

    Kirienko, Natalia V; Mani, Kumaran; Fay, David S

    2010-05-01

    Although now dogma, the idea that nonvertebrate organisms such as yeast, worms, and flies could inform, and in some cases even revolutionize, our understanding of oncogenesis in humans was not immediately obvious. Aided by the conservative nature of evolution and the persistence of a cohort of devoted researchers, the role of model organisms as a key tool in solving the cancer problem has, however, become widely accepted. In this review, we focus on the nematode Caenorhabditis elegans and its diverse and sometimes surprising contributions to our understanding of the tumorigenic process. Specifically, we discuss findings in the worm that address a well-defined set of processes known to be deregulated in cancer cells including cell cycle progression, growth factor signaling, terminal differentiation, apoptosis, the maintenance of genome stability, and developmental mechanisms relevant to invasion and metastasis. Copyright (c) 2010 Wiley-Liss, Inc.

  14. Comparison of air-sea fluxes of CO2 in the Southern Ocean and the western Arctic Ocean

    Institute of Scientific and Technical Information of China (English)

    CHEN Liqi; GAO Zhongyong; YANG Xulin; WANG Weiqiang

    2004-01-01

    The data were collected during Chinese Arctic and Antarctic Expeditions in the western Arctic Ocean and the marginal sea ice zone (MSIZ) of the Southern Ocean, respectively in the boreal summer from July to September of 1999 and in the austral summer from December of 1999 to January of 2000. The concentrations of CO2 in surface water of the survey regions would mostly present lower than those in the atmosphere. A significant biological driving force could also been observed in summer waters in both of the above oceans. Air to sea CO2 fluxes were also calculated to compare oceanic uptake capacity of CO2 in both oceans with the world oceans using Liss, Wanninkhof,and Jacobs' s methods. The averaged CO2 fluxes of air to sea in the western Arctic Ocean or in the MSIZ of the Southern Ocean doubled that in the world oceans.

  15. Bilateral carpal valgus deformity in hand-reared cheetah cubs (Acinonyx jubatus).

    Science.gov (United States)

    Bell, Katherine M; van Zyl, Malan; Ugarte, Claudia E; Hartman, Angela

    2011-01-01

    Four hand-reared cheetah cubs (Acinonyx jubatus) exhibited progressively severe bilateral valgus deformity of the carpi (CV) during the weaning period. Radiographs of the thoracic limbs suggested normal bone ossification, and serum chemistry was unremarkable. All affected cubs developed CV shortly after the onset of gastroenteritis, which was treated medically, and included use of a prescription diet. A sudden decrease in growth rate was associated with gastrointestinal disease. Before gastroenteritis and CV, affected cubs had higher growth rates than unaffected cubs, despite similar mean daily energy intake. Return to normal thoracic limb conformation was consequent to dietary manipulation (including a reduction in energy intake and vitamin and mineral supplementation), as well as decreased growth rates and recovery from gastroenteritis. The cause of the CV is likely to have been multi-factorial with potentially complex physiological interactions involved. © 2010 Wiley-Liss, Inc.

  16. Does major depressive disorder in parents predict specific fears and phobias in offspring?

    Science.gov (United States)

    Biel, Matthew G; Klein, Rachel G; Mannuzza, Salvatore; Roizen, Erica R; Truong, Nhan L; Roberson-Nay, Roxann; Pine, Daniel S

    2008-01-01

    Evidence suggests a relationship between parental depression and phobias in offspring as well as links between childhood fears and risk for major depression. This study examines the relationship between major depressive disorder (MDD) and anxiety disorders in parents and specific fears and phobias in offspring. Three hundred and eighteen children of parents with lifetime MDD, anxiety disorder, MDD+anxiety disorder, or neither were psychiatrically assessed via parent interview. Rates of specific phobias in offspring did not differ significantly across parental groups. Specific fears were significantly elevated in offspring of parents with MDD+anxiety disorder relative to the other groups (MDD, anxiety disorder, and controls, which did not differ). We failed to find increased phobias in offspring of parents with MDD without anxiety disorder. Elevated rates of specific fears in offspring of parents with MDD+anxiety disorder may be a function of more severe parental psychopathology, increased genetic loading, or unmeasured environmental influences. (c) 2007 Wiley-Liss, Inc.

  17. Does social media improve communication? Evaluating the NIOSH science blog.

    Science.gov (United States)

    Sublet, Virginia; Spring, Christina; Howard, John

    2011-05-01

    In 2007, NIOSH created the Science Blog as its first social media channel. The blog has more than 22,000 subscribers. The purpose of the evaluation was to identify the blog community of readers, its use as a two-way conversation channel and its effectiveness as an information resource. Seventy-five readers randomly participated in an online survey from July 2009 to September 2009 to evaluate the Science Blog. Responses indicated that the NIOSH Science Blog was a valued social media resource. Sixty percent of participants planned to continue using the blog in the next 6 months. A significant proportion of readers reported that they would make changes in the workplace based on information obtained from the Science Blog. The NIOSH Science Blog provides is a useful communication channel to provide workplace safety and health information and expand the Institute's reach to new consumers. Copyright © 2011 Wiley-Liss, Inc.

  18. Expression of chondrogenic potential of mouse trunk neural crest cells by FGF2 treatment.

    Science.gov (United States)

    Ido, Atsushi; Ito, Kazuo

    2006-02-01

    There is a significant difference between the developmental patterns of cranial and trunk neural crest cells in the amniote. Thus, whereas cranial neural crest cells generate bone and cartilage, trunk neural crest cells do not contribute to skeletal derivatives. We examined whether mouse trunk neural crest cells can undergo chondrogenesis to analyze how the difference between the developmental patterns of cranial and trunk neural crest cells arises. Our present data demonstrate that mouse trunk neural crest cells have chondrogenic potential and that fibroblast growth factor (FGF) 2 is an inducing factor for their chondrogenesis in vitro. FGF2 altered the expression patterns of Hox9 genes and Id2, a cranial neural crest cell marker. These results suggest that environmental cues may play essential roles in generating the difference between developmental patterns of cranial and trunk neural crest cells. Copyright 2005 Wiley-Liss, Inc.

  19. Myotonic dystrophy protein kinase (DMPK) induces actin cytoskeletal reorganization and apoptotic-like blebbing in lens cells

    Science.gov (United States)

    Jin, S.; Shimizu, M.; Balasubramanyam, A.; Epstein, H. F.

    2000-01-01

    DMPK, the product of the DM locus, is a member of the same family of serine-threonine protein kinases as the Rho-associated enzymes. In DM, membrane inclusions accumulate in lens fiber cells producing cataracts. Overexpression of DMPK in cultured lens epithelial cells led to apoptotic-like blebbing of the plasma membrane and reorganization of the actin cytoskeleton. Enzymatically active DMPK was necessary for both effects; inactive mutant DMPK protein did not produce either effect. Active RhoA but not constitutive GDP-state mutant protein produced similar effects as DMPK. The similar actions of DMPK and RhoA suggest that they may function in the same regulatory network. The observed effects of DMPK may be relevant to the removal of membrane organelles during normal lens differentiation and the retention of intracellular membranes in DM lenses. Copyright 2000 Wiley-Liss, Inc.

  20. Embryogenesis and laboratory maintenance of the foam-nesting túngara frogs, genus Engystomops (= Physalaemus).

    Science.gov (United States)

    Romero-Carvajal, Andrés; Sáenz-Ponce, Natalia; Venegas-Ferrín, Michael; Almeida-Reinoso, Diego; Lee, Chanjae; Bond, Jennifer; Ryan, Michael J; Wallingford, John B; Del Pino, Eugenia M

    2009-06-01

    The vast majority of embryological research on amphibians focuses on just a single genus of frogs, Xenopus. To attain a more comprehensive understanding of amphibian development, experimentation on non-model frogs will be essential. Here, we report on the early development, rearing, and embryological analysis of túngara frogs (genus Engystomops, also called Physalaemus). The frogs Engystomops pustulosus, Engystomops coloradorum, and Engystomops randi construct floating foam-nests with small eggs. We define a table of 23 stages for the developmental period in the foam-nest. Embryos were immunostained against Lim1, neural, and somite-specific proteins and the expression pattern of RetinoBlastoma Binding Protein 6 (RBBP6) was analyzed by in situ hybridization. Due to their brief life-cycle, frogs belonging to the genus Engystomops are attractive for comparative and genetic studies of development. Developmental Dynamics 238:1444-1454, 2009. (c) 2009 Wiley-Liss, Inc.

  1. An improved Flp deleter mouse in C57Bl/6 based on Flpo recombinase.

    Science.gov (United States)

    Kranz, Andrea; Fu, Jun; Duerschke, Kristin; Weidlich, Stefanie; Naumann, Ronald; Stewart, A Francis; Anastassiadis, Konstantinos

    2010-08-01

    Recently, a codon improved version of the Flpe site specific recombinase, termed Flpo, was reported as having greatly improved performance in mammalian cell applications. However, the degree of improvement could not be estimated because essentially no Flpe activity was observed. Here, we compare Flpe and Flpo accurately in a mammalian cell assay to estimate that Flpo is about five times more active than Flpe and similar to Cre and Dre. Consequently, we generated a Flpo deleter mouse line from the JM8 C57Bl/6 ES cells used in the EUCOMM and KOMP systematic knock-out programs. In breeding experiments, we show that the Flpo deleter delivers complete recombination using alleles that are incompletely recombined by a commonly used Flpe deleter. This indicates that the Flpo deleter is more efficient. (c) 2010 Wiley-Liss, Inc.

  2. Media violence, physical aggression, and relational aggression in school age children: a short-term longitudinal study.

    Science.gov (United States)

    Gentile, Douglas A; Coyne, Sarah; Walsh, David A

    2011-01-01

    Many studies have shown that media violence has an effect on children's subsequent aggression. This study expands upon previous research in three directions: (1) by examining several subtypes of aggression (verbal, relational, and physical), (2) by measuring media violence exposure (MVE) across three types of media, and (3) by measuring MVE and aggressive/prosocial behaviors at two points in time during the school year. In this study, 430 3rd-5th grade children, their peers, and their teachers were surveyed. Children's consumption of media violence early in the school year predicted higher verbally aggressive behavior, higher relationally aggressive behavior, higher physically aggressive behavior, and less prosocial behavior later in the school year. Additionally, these effects were mediated by hostile attribution bias. The findings are interpreted within the theoretical framework of the General Aggression Model. © 2010 Wiley-Liss, Inc.

  3. 2014 Zero Waste Strategic Plan Executive Summary.

    Energy Technology Data Exchange (ETDEWEB)

    Wrons, Ralph J.

    2016-05-01

    Sandia National Laboratories/New Mexico is located in Albuquerque, New Mexico, primarily on Department of Energy (DOE) permitted land on approximately 2,800 acres of Kirtland Air Force Base. There are approximately 5.5 million square feet of buildings, with a workforce of approximately 9200 personnel. Sandia National Laboratories Materials Sustainability and Pollution Prevention (MSP2) program adopted in 2008 an internal team goal for New Mexico site operations for Zero Waste to Landfill by 2025. Sandia solicited a consultant to assist in the development of a Zero Waste Strategic Plan. The Zero Waste Consultant Team selected is a partnership of SBM Management Services and Gary Liss & Associates. The scope of this Plan is non-hazardous solid waste and covers the life cycle of material purchases to the use and final disposal of the items at the end of their life cycle.

  4. Risk factors for treatment related mortality in childhood acute lymphoblastic leukaemia

    DEFF Research Database (Denmark)

    Lund, Bendik; Åsberg, Ann; Heyman, Mats;

    2011-01-01

    bleeding or thrombosis (eight patients), tumour burden related toxicities (seven patients) and organ toxicity (seven patients). Female gender (hazard ratio (HR): 2.2, 95% confidence interval (95% CI): 1.4-3.4), high white blood cell count (=200¿×¿10(9)/L) at diagnosis (HR: 3.5, 95% CI: 1.7-7.1), T.......2%), and the overall subsequent risk of induction death and death in first complete remission (CR1) was 1.2% and 1.8%, respectively. Infections were the major cause of death comprising 72% of all cases including 9 deaths from Pseudomonas aeruginosa and 11 deaths from fungal infections. Other causes of death included...... towards patients at risk. Pediatr Blood Cancer. © 2010 Wiley-Liss, Inc....

  5. Risk factors for treatment related mortality in childhood acute lymphoblastic leukaemia

    DEFF Research Database (Denmark)

    Lund, Bendik; Åsberg, Ann; Heyman, Mats;

    2011-01-01

    bleeding or thrombosis (eight patients), tumour burden related toxicities (seven patients) and organ toxicity (seven patients). Female gender (hazard ratio (HR): 2.2, 95% confidence interval (95% CI): 1.4-3.4), high white blood cell count (≥200 × 10(9)/L) at diagnosis (HR: 3.5, 95% CI: 1.7-7.1), T.......2%), and the overall subsequent risk of induction death and death in first complete remission (CR1) was 1.2% and 1.8%, respectively. Infections were the major cause of death comprising 72% of all cases including 9 deaths from Pseudomonas aeruginosa and 11 deaths from fungal infections. Other causes of death included...... towards patients at risk. Pediatr Blood Cancer. © 2010 Wiley-Liss, Inc....

  6. Contributions to the Data Warehouse 2 and Prospects of the IRS Program

    Science.gov (United States)

    Barner, Frithjof; Venkataraman, V. Raghu; Makiola, Jens

    2016-08-01

    During 2015 and 2016, the IRS program has significantly contributed to the CSC-DA Data Warehouse. From its suite of optical EO satellites which operate in the visible, near IR and shortwave IR domain, data from the HR LISS-III and MR AWiFS sensors on board of Resourcesat-2 have been provided. Resourcesat-2 so far acquired cloud-free images of a vast majority of the first and second coverage of HR_IMAGE_2015 and several monthly MR coverages for MR_IMAGE_2015 over the EEA-39. The results regarding the above mentioned data sets will be discussed including an appraisal of the possible future role of upcoming IRS EO satellites for European data requirements.

  7. Contribution To The Data Warehouse And Prospects Of The IRS Program

    Science.gov (United States)

    Barner, Frithjof; Haydn, Rupert; Parmar, Manish; Makiola, Jens

    2013-12-01

    Over the past two years, the IRS program has again significantly contributed to the GSC-DA Data Warehouse. From its suite of optical EO satellites which operate in the visible, near IR and shortwave IR domain, multispectral data from the HR LISS-III and MR AWiFS sensors have been provided. Both cameras are implemented on board of Resourcesat-1 and Resourcesat-2 respectively. Despite reduced capacities, the Resourcesat constellation of satellites so far acquired cloud-free images of a vast majority of the first HR coverage of CORE_001 and several monthly MR coverages for CORE_008 over the EEA-39. The results regarding the above mentioned data sets will be discussed including an appraisal of the possible future role of upcoming IRS EO satellites for European data requirements.

  8. Angelman syndrome: Mutations influence features in early childhood.

    Science.gov (United States)

    Tan, Wen-Hann; Bacino, Carlos A; Skinner, Steven A; Anselm, Irina; Barbieri-Welge, Rene; Bauer-Carlin, Astrid; Beaudet, Arthur L; Bichell, Terry Jo; Gentile, Jennifer K; Glaze, Daniel G; Horowitz, Lucia T; Kothare, Sanjeev V; Lee, Hye-Seung; Nespeca, Mark P; Peters, Sarika U; Sahoo, Trilochan; Sarco, Dean; Waisbren, Susan E; Bird, Lynne M

    2011-01-01

    Angelman syndrome (AS) is a neurodevelopmental disorder caused by a lack of expression of the maternal copy of UBE3A. Although the "classic" features of AS are well described, few large-scale studies have delineated the clinical features in AS. We present baseline data from 92 children with a molecular diagnosis of AS between 5 and 60 months old who are enrolled in the National Institutes of Health Rare Diseases Clinical Research Network Angelman Syndrome Natural History Study from January 2006 to March 2008. Seventy-four percent of participants had deletions, 14% had either uniparental disomy (UPD) or imprinting defects, and 12% had UBE3A mutations. Participants with UPD/imprinting defects were heavier (P = 0.0002), while those with deletions were lighter, than the general population (P phenotype, but specific EEG findings are highly sensitive for AS. Obesity is common among those with UPD/imprinting defects. Copyright © 2010 Wiley-Liss, Inc.

  9. En bloc pancreaticoduodenectomy for right colon cancer invading adjacent organs.

    Science.gov (United States)

    Berrospi, Francisco; Celis, Juan; Ruiz, Eloy; Payet, Eduardo

    2002-03-01

    Surgical treatment of colorectal cancer needs an extended resection of the tumor en block with invaded organs. There is little information about the surgical treatment of right-sided colon carcinoma directly involving duodenum and pancreas. Our objective is to report our experience with three patients who underwent en bloc pancreaticoduodenectomy and hemicolectomy for locally advanced right colon cancer. Retrospective review of clinical records of patients with colon cancer. Three patients with right colon cancer adherent to adjacent organs underwent en block surgery. No operative deaths occurred. All patients are alive without evidence of disease at 10, 30, 113 months of follow-up, respectively. Locally advanced right-sided colon cancer can be safely treated with en bloc pancreaticoduodenectomy and colectomy with excellent long-term results. Copyright 2002 Wiley--Liss, Inc.

  10. Hominid cranium from Omo: Description and taxonomy of Omo-323-1976-896.

    Science.gov (United States)

    Alemseged, Zeresenay; Coppens, Yves; Geraads, Denis

    2002-02-01

    Omo-323-1976-896, a partial hominid cranium dated to ca. 2.1 from the Member G, Unit G-8 of the Shungura Formation, lower Omo Basin of Ethiopia, is described. It is suggested that the specimen is an adult male based on the well-developed and completely fused sagittal crest; heavily worn teeth; relatively large canine; and size of the articular eminence. Omo-323 consists of fragments of the frontal, both temporals, occipital, parietals, and the right maxilla, and is attributed to Australopithecus boisei, making it the oldest known cranium of this species. The specimen shares features with Australopithecus aethiopicus (KNM-WT 17000), thus supporting the existence of an evolving East African robust lineage between ca. 2.6-1.2 Ma. The morphology of Omo-323 increases our knowledge of the intraspecific variability of A.boisei. Copyright 2002 Wiley-Liss, Inc.

  11. Evaluation of RF electromagnetic field exposure levels from cellular base stations in Korea.

    Science.gov (United States)

    Kim, Byung Chan; Park, Seong-Ook

    2010-09-01

    This article presents the measurement results of human exposure to CDMA800 and CDMA1800 signals at locations in Korea where the general public has expressed concern. Measurements were performed at 50 locations across the country to compare the electromagnetic field levels with the general public exposure compliance limits. At each site, the distances between the nearest single or co-located base station and measurement positions were within a range of approximately 32-422 m. The measured exposure levels were very low compared with the international standard and the Korean human protection notice. The highest field level was 1.5 V/m, which corresponds to 0.15% of the International Commission on Non-Ionizing Radiation Protection (ICNIRP) guidelines for human exposure. 2010 Wiley-Liss, Inc.

  12. BOLD MRI of the human cervical spinal cord at 3 tesla.

    Science.gov (United States)

    Stroman, P W; Nance, P W; Ryner, L N

    1999-09-01

    The feasibility of functional MRI of the spinal cord was investigated by carrying out blood oxygen-level dependent (BOLD) imaging of the human cervical spinal cord at a field of 3 T. BOLD imaging of the cervical spinal cord showed an average intensity increase of 7.0% during repeated exercise with the dominant hand with a return to baseline during rest periods. The areas of activation were predominantly on the same side of the spinal cord as the hand performing the exercise, between the levels of the sixth cervical and first thoracic spinal cord segments. The direct correspondence between these areas and those involved with the transmission of motor impulses to the hand, and reception of sensory information from the hand, demonstrates that spinal functional magnetic resonance imaging is feasible. Magn Reson Med 42:571-576, 1999. Copyright 1999 Wiley-Liss, Inc.

  13. Clinical functional MRI of sensorimotor cortex using passive motor and sensory stimulation at 3 Tesla.

    Science.gov (United States)

    Blatow, Maria; Reinhardt, Julia; Riffel, Katharina; Nennig, Ernst; Wengenroth, Martina; Stippich, Christoph

    2011-08-01

    To establish a passive motor paradigm for clinical functional MRI (fMRI) that could be beneficial for patients with motor or attention deficits who are not able to perform active motor tasks. A novel standardized sensorimotor fMRI protocol was applied in 16 healthy volunteers at 3 Tesla (T) using active and passive motor tasks as well as sensory stimulation of hands and feet. Data analysis was carried out individually using a dynamic thresholding routine. Active motor tasks yielded time efficient and robust blood-oxygen-level-dependent (BOLD) signals in primary motor cortex. Noteworthy, it was possible to achieve equal activation levels within identical anatomical localization for passive and active motor tasks with these paradigms. Patients unable to perform active movements can benefit from paradigms with passive motor and sensory stimulation. Therefore, we recommend these paradigms for functional somatotopic mapping of the central region at 3T in clinical routine. Copyright © 2011 Wiley-Liss, Inc.

  14. Evaluation of course change detection of Ramganga river using remote sensing and GIS, India

    Directory of Open Access Journals (Sweden)

    Satya Prakash Maurya

    2016-09-01

    Full Text Available Visibility of Ramganga river course change detection was made using Remote Sensing and GIS in study area among period of forty-one years from 1972 to 2013. Landsat MSS, TM, ETM+, LISS-III satellite images from 1972, 1989, 2000, 2006, and 2013 respectively were used to delineate the historical changes of the river course. This study shows that for a long time this area has been suffering due to erosion problem and shifting characteristics of the Ramganga River. The Ramganga river course has been shifting and the overall shifting is towards the south-west direction in different places which leads to the village erosion. The area has remained undeveloped due to infrastructure damaged by flood, changing course. This study may be helpful for the overall river management and planning for future prevention of food, changing coursing, loss of properties.

  15. Preterm neonatal diffusion processing using detection and replacement of outliers prior to resampling.

    Science.gov (United States)

    Morris, Drew; Nossin-Manor, Revital; Taylor, Margot J; Sled, John G

    2011-07-01

    In diffusion weighted MRI, subject motion and brain pulsation lead both to signal drop-outs and image misalignment. Unsedated neonates, with their higher heart rate and propensity for motion are particularly prone to degraded scan quality that impairs diffusion tensor estimation. Retrospective registration and robust estimators are two methods that have previously been demonstrated to address motion and intensity outliers, respectively, in diffusion data. However, when taken together, the resampling of images to correct for misalignment can have the effect of averaging outlier voxels with uncorrupted voxels, thereby making outliers more difficult to detect. This article presents a method to remove outliers prior to resampling while taking misalignment into account so that this averaging of outliers with good data can be avoided. The proposed method is compared to other processing pipelines using simulations and data from unsedated preterm neonates. These results demonstrate advantages to the proposed method, particularly in subjects with high motion. Copyright © 2010 Wiley-Liss, Inc.

  16. X-linked dominant chondrodysplasia punctata (CDPX2) caused by single gene mosaicism in a male.

    Science.gov (United States)

    Aughton, David J; Kelley, Richard I; Metzenberg, Aida; Pureza, Vincent; Pauli, Richard M

    2003-01-30

    X-linked dominant chondrodysplasia punctata (CDPX2; Happle syndrome) is recognized almost exclusively in females, who display mosaic and asymmetric features, presumed to arise secondary to random X-inactivation. CDPX2 results from mutation of an X-linked gene coding for sterol-delta(8)-delta(7) isomerase (emopamil binding protein). We describe a boy with clinical features of CDPX2 (including those presumed to arise usually secondary to functional mosaicism in females). Biochemical and molecular studies demonstrate that he is mosaic for a sterol-delta(8)-delta(7) isomerase gene mutation. He is the first reported example of single gene mosaicism giving rise to CDPX2 in a male. Copyright 2002 Wiley-Liss, Inc.

  17. Model quality assessment using distance constraints from alignments

    DEFF Research Database (Denmark)

    Paluszewski, Martin; Karplus, Kevin

    2008-01-01

    Given a set of alternative models for a specific protein sequence, the model quality assessment (MQA) problem asks for an assignment of scores to each model in the set. A good MQA program assigns these scores such that they correlate well with real quality of the models, ideally scoring best...... with the best MQA methods that were assessed at CASP7. We also propose a new evaluation measure, Kendall's tau, that is more interpretable than conventional measures used for evaluating MQA methods (Pearson's r and Spearman's rho). We show clear examples where Kendall's tau agrees much more with our intuition...... of a correct MQA, and we therefore propose that Kendall's tau be used for future CASP MQA assessments. Proteins 2009. (c) 2008 Wiley-Liss, Inc....

  18. Enhanced effects of nonisotopic hafnium chloride in methanol as a substitute for uranyl acetate in TEM contrast of ultrastructure of fungal and plant cells.

    Science.gov (United States)

    Ikeda, Ken-Ichi; Inoue, Kanako; Kanematsu, Satoko; Horiuchi, Yoshitaka; Park, Pyoyun

    2011-09-01

    This ultrastructural study showed that nonisotopic methanolic hafnium chloride and aqueous lead solution was an excellent new electron stain for enhancing TEM contrasts of fungal and plant cell structures. The ultrastructural definition provided by the new stain was often superior to that provided by conventional staining with uranyl acetate and lead. Definition of fine ultrastructure was also supported by quantitative data on TEM contrast ratios of organelles and components in fungal and plant cells. In particular, polysaccharides, which were localized in cell walls, glycogen particles, starch grains, and plant Golgi vesicle components, were much more reactive to the new stain than to the conventional one. The new nonisotopic stain is useful for enhancing the contrast of ultrastructure in biological tissues and is a safer alternative to uranyl acetate. Copyright © 2010 Wiley-Liss, Inc.

  19. AN EFFICIENT APPROACH FOR EXTRACTION OF LINEAR FEATURES FROM HIGH RESOLUTION INDIAN SATELLITE IMAGERIES

    Directory of Open Access Journals (Sweden)

    DK Bhattacharyya

    2010-07-01

    Full Text Available This paper presents an Object oriented feature extraction approach in order to classify the linear features like drainage, roads etc. from high resolution Indian satellite imageries. It starts with the multiresolution segmentations of image objects for optimal separation and representation of image regions or objects. Fuzzy membership functions were defined for a selected set of image object parameters such as mean, ratio, shape index, area etc. for representation of required image objects. Experiment was carried out for both panchromatic (CARTOSAT-I and multispectral (IRSP6 LISS IV Indiansatellite imageries. Experimental results show that the extractionof linear features can be achieved in a satisfactory level throughproper segmentation and appropriate definition & representationof key parameters of image objects.

  20. A 3 Mb deletion in 14q12 causes severe mental retardation, mild facial dysmorphisms and Rett-like features.

    Science.gov (United States)

    Papa, Filomena Tiziana; Mencarelli, Maria Antonietta; Caselli, Rossella; Katzaki, Eleni; Sampieri, Katia; Meloni, Ilaria; Ariani, Francesca; Longo, Ilaria; Maggio, Angela; Balestri, Paolo; Grosso, Salvatore; Farnetani, Maria Angela; Berardi, Rosario; Mari, Francesca; Renieri, Alessandra

    2008-08-01

    The present report describes a 7-year-old girl with a de novo 3 Mb interstitial deletion of chromosome 14q12, identified by oligo array-CGH. The region is gene poor and contains only five genes two of them, FOXG1B and PRKD1 being deleted also in a previously reported case with a very similar phenotype. Both patients present prominent metopic suture, epicanthic folds, bulbous nasal tip, tented upper lip, everted lower lip and large ears and a clinical course like Rett syndrome, including normal perinatal period, postnatal microcephaly, seizures, and severe mental retardation. FOXG1B (forkhead box G1B) is a very intriguing candidate gene since it is known to promote neuronal progenitor proliferation and to suppress premature neurogenesis and its disruption is reported in a patient with postnatal microcephaly, corpus callosum agenesis, seizures, and severe mental retardation. Copyright 2008 Wiley-Liss, Inc.

  1. Der umgedrehte Plattenfixateur zur osteosynthetischen Stabilisierung bei erschwerter Frakturheilung am proximalen Femur

    DEFF Research Database (Denmark)

    Mehlhorn, A T; Strohm, P C; Müller, C A

    2009-01-01

    AIM: The aim of the study was to evaluate the application of a locked internal fixator in complex fractures of the proximal femur, in which the internal fixation with standard implants was not possible due to poor quality of bone or already failed internal fixation in the past. METHOD: Ten patients...... suffering from a pertrochanteric (n = 5), periprosthetic (n = 1) or subtrochanteric (n = 4) femural fracture between 2003 and 2008 were prospectively registered, underwent open reduction and internal fixation with an "upside-down" femur LISS (less invasive stabilisation system) and were followed up. In all...... of the implant. CONCLUSIONS: The "reversed" locked internal fixator could be a successful alternative implant for stabilisation of proximal femur fractures which could not be fixated by standard implants due to poor bone quality and circulation. It can also be used as a salvage procedure after internal failed...

  2. Mechanism by which an elevation of extracellular glucide concentration induces pigment aggregation in medaka melanophores.

    Science.gov (United States)

    Fujii, Ryozo; Goda, Makoto; Oshima, Noriko

    2002-09-15

    An increase in glucide concentration induces pigment aggregation in melanophores in the skin on scales isolated from the medaka, Oryzias latipes. In this study, hexoses (including the common D-isomers of glucose, galactose, fructose, and mannitol) were examined. Denervated melanophores were refractory to such stimuli. An alpha-adrenolytic agent, phentolamine, effectively blocked the responses of normally innervated melanophores. The pigment-aggregating action of glucide was inhibited by withdrawal of Ca(2+) and Mg(2+) ions from the medium. A specific blocker of voltage-dependent N-type Ca(2+) channels, the omega-conotoxin GVIA, also inhibited the glucide action. The conclusion derived is that an elevation of glucide levels acts to open Ca(2+) channels of presynaptic membranes of sympathetic postganglionic fibers, and the consequently released adrenergic transmitter acts on the effector cells to induce the aggregation of their pigmentary organelles. Copyright 2002 Wiley-Liss, Inc.

  3. A novel report of cig-FISH and cytogenetics in POEMS syndrome.

    Science.gov (United States)

    Bryce, Alan H; Ketterling, Rhett P; Gertz, Morie A; Lacy, Martha; Knudson, Ryan A; Kumar, Shaji; Kyle, Robert A; Fonseca, Rafael; Greipp, Phillip R; Lust, John A; Rajkumar, Vincent S; Hayman, Suzanne R; Buadi, Francis; Russell, Stephen J; Zeldenrust, Stephen R; Dispenzieri, Angela

    2008-11-01

    POEMS syndrome is a plasma cell proliferative disorder whose pathogenesis is poorly understood. We provide the first report of cytoplasmic immunoglobulin/FISH testing (cIg-FISH) in POEMS syndrome using established myeloma markers. We reviewed all 37 POEMS cases seen at our institution in which cIg-FISH testing had been obtained. Monosomy 13 was seen in 14 of the 37 (38%) cIg-FISH samples. One patient had trisomy 3 and 7. Three patients had IgH translocation t(11;14)(q13;q32). No abnormalities were seen at 17p13(p53). The monosomy 13 is in line with other plasma cell disorders while the low prevalence of hyperdiploidy and abnormalities at 14q32 is unique. Copyright 2008 Wiley-Liss, Inc.

  4. El teorema de Riemann-Roch y el morfismo de Gysin en geometría aritmética

    OpenAIRE

    Navarro Garmendia, Alberto

    2016-01-01

    Le th eor eme de Riemann-Roch originale a rme que pour tout morphisme propre f : Y ! X entre vari et es quasi-projectifs lisses sur un corps, et tout el ement a 2 K0(Y ) du groupe de Grothendieck des br es vectoriels on a ch(f!(a)) = f {u100000}Td(Tf ) ch(a) (cf. [BS58]). Ici ch est le caract ere de Chern, Td(Tf ) est la classe de Todd du br e tangent relative et f et f! sont les images directes de l'anneau de Chow et K0 respectivement. Apr es, Baum, Fulton et MacPherson ont d emontr e...

  5. Distribution of amelotin in mouse tooth development.

    Science.gov (United States)

    Gao, Yuguang; Wang, Wanchun; Sun, Yan; Zhang, Juanjuan; Li, Dongliang; Wei, Yahong; Han, Tingting

    2010-01-01

    Amelotin is expressed and secreted by ameloblasts in tooth development, but amelotin distribution during enamel development is not clear. In this report, we first investigated amelotin expression in developing teeth by immunohistochemistry. Amelotin was detected in the enamel matrix at the secretion and maturation stages of enamel development. Amelotin was also observed at Tomes' processes on the apical ends of secretory ameloblasts. We then compared amelotin gene expression with those of amelogenin, enamelin, and ameloblastin in the mandibles of postnatal mice by RT-PCR. The expression of amelotin was detected as early as in postnatal day 0 mandibles and amelotin was coexpressed with amelogenin, ameloblastin, and enamelin during tooth development. These data strongly suggest that amelotin is an enamel matrix protein expressed at the secretion and maturation stages of enamel development. (c) 2009 Wiley-Liss, Inc.

  6. FIESTA-ET: high-resolution cardiac imaging using echo-planar steady-state free precession.

    Science.gov (United States)

    Slavin, Glenn S; Saranathan, Manojkumar

    2002-12-01

    This work describes a technique that combines multishot echo-planar imaging (EPI) with steady-state free precession (SSFP, also known as TrueFISP, FIESTA, and balanced FFE) for multislice, cine MR imaging of the heart. Unlike recently reported methods, the technique presented here (FIESTA-ET) is high-resolution and does not require offline reconstruction or postprocessing. It is therefore suitable for use on standard clinical scanners. FIESTA-ET was compared with conventional FIESTA imaging in 10 volunteers and quantitative analyses of myocardial signal-to-noise ratios (SNR) and ventricular volumes were performed. While providing comparable image quality, FIESTA-ET required half the acquisition time per slice of conventional FIESTA. Because multiple slices could be imaged in a single breathhold, the entire heart could be scanned in less than 2 min. Although the FIESTA-ET images exhibited an unexpected increase (P FIESTA, the volumetric measurements showed excellent correlation. Copyright 2002 Wiley-Liss, Inc.

  7. Volumetric analysis of the African elephant ventricular system.

    Science.gov (United States)

    Maskeo, Busisiwe C; Spocter, Muhammed A; Haagensen, Mark; Manger, Paul R

    2011-08-01

    This study used magnetic resonance imaging (MRI) to determine the volume of the ventricular system in the brain of three adult male African elephants (Loxodonta africana). The ventricular system of the elephant has a volume of ∼240 mL, an order of magnitude larger than that seen in the adult human. Despite this large size, allometric analysis indicates that the volume of the ventricles in the elephant is what one would expect for a mammal with an ∼5 kg brain. Interestingly, our comparison with other mammals revealed that primates appear to have small relative ventricular volumes, and that megachiropterans and microchiropterans follow different scaling rules when comparing ventricular volume to brain mass indicating separate phylogenetic histories. The current study provides context for one aspect of the elephant brain in the broader picture of mammalian brain evolution. Copyright © 2011 Wiley-Liss, Inc.

  8. Automated docking to multiple target structures: incorporation of protein mobility and structural water heterogeneity in AutoDock.

    Science.gov (United States)

    Osterberg, Fredrik; Morris, Garrett M; Sanner, Michel F; Olson, Arthur J; Goodsell, David S

    2002-01-01

    Protein motion and heterogeneity of structural waters are approximated in ligand-docking simulations, using an ensemble of protein structures. Four methods of combining multiple target structures within a single grid-based lookup table of interaction energies are tested. The method is evaluated using complexes of 21 peptidomimetic inhibitors with human immunodeficiency virus type 1 (HIV-1) protease. Several of these structures show motion of an arginine residue, which is essential for binding of large inhibitors. A structural water is also present in 20 of the structures, but it must be absent in the remaining one for proper binding. Mean and minimum methods perform poorly, but two weighted average methods permit consistent and accurate ligand docking, using a single grid representation of the target protein structures. Copyright 2001 Wiley-Liss, Inc.

  9. Post cardiac transplantation lymphoproliferative disorder presenting as t(8;14) Burkitt leukaemia/lymphoma treated with low intensity chemotherapy and rituximab.

    Science.gov (United States)

    Windebank, Kevin; Walwyn, Tom; Kirk, Richard; Parry, Gareth; Hasan, Asif; Bown, Nick; Wilkins, Bridget

    2009-09-01

    Post-transplant lymphoproliferative disorder (PTLD) occasionally presents as Burkitt lymphoma/L3 leukaemia (BLL). We reviewed records of cases of PTLD post-cardiac transplantation (1990-2007) occurring in our unit. There were 15 episodes in 13 patients including four cases of EBV-driven Burkitt-type disease with t(8;14) translocations presenting with advanced stage disease. The first case was treated with a variety of low dose chemotherapy combinations. Despite problems during therapy he obtained complete remission, but died from complications of pre-existing cardiac allograft vasculopathy 7 months later. The subsequent three cases were treated with a UKCCSG low stage lymphoma protocol, NHL 9001 and Rituximab. They remain in complete remission. In the context of PTLD the prognostic significance of advanced stage EBV-driven BLL with the t(8;14) translocation may be different to that in immunocompetent children. (c) 2009 Wiley-Liss, Inc.

  10. The role of developmental plasticity and epigenetics in human health.

    Science.gov (United States)

    Gluckman, Peter D; Hanson, Mark A; Low, Felicia M

    2011-03-01

    Considerable epidemiological, experimental and clinical data have amassed showing that the risk of developing disease in later life is dependent on early life conditions, mainly operating within the normative range of developmental exposures. This relationship reflects plastic responses made by the developing organism as an evolved strategy to cope with immediate or predicted circumstances, to maximize fitness in the context of the range of environments potentially faced. There is now increasing evidence, both in animals and humans, that such developmental plasticity is mediated in part by epigenetic mechanisms. However, recognition of the importance of developmental plasticity as an important factor in influencing later life health-particularly within the medical and public health communities-is low, and we argue that this indifference cannot be sustained in light of the growing understanding of developmental processes and the rapid rise in the prevalence of obesity and metabolic disease globally. Copyright © 2011 Wiley-Liss, Inc.

  11. Buying time for wild animals with zoos.

    Science.gov (United States)

    Conway, William G

    2011-01-01

    Zoos and aquariums exhibit many rare species, but sustain few for long periods. Demanding genetic, demographic, and behavioral requirements are a part of the sustainability challenge, and historical zoo goals and limiting animal management objectives are another, but they have been overtaken by worldwide wildlife population contraction and endangerment. New policies are essential for zoo continuance and, if vanishing species are to be helped by zoo propagation, they must be given priority. However, zoos have little animal carrying capacity and propagation must be much more sharply focused. In addition, it is becoming urgent that zoos help to support parks and reserves and, where possible, manage some especially endangered species mutually with parks. © 2010 Wiley-Liss, Inc.

  12. Current husbandry of red pandas (Ailurus fulgens) in zoos.

    Science.gov (United States)

    Eriksson, P; Zidar, J; White, D; Westander, J; Andersson, M

    2010-01-01

    The endangered red panda (Ailurus fulgens) is held in zoos worldwide. The aim of this study was to examine how red pandas are kept and managed in captivity and to compare it with the management guidelines. Sixty-nine zoos, mainly from Europe but also from North America and Australia/New Zealand, responded to our survey. The results revealed that in general zoos follow the management guidelines for most of the investigated issues. The average enclosure is almost four times larger than the minimum size recommended by the management guidelines, although seven zoos have smaller enclosures. About half the zoos do not follow the guidelines concerning visitor access and number of nest boxes. Other issues that may compromise animal welfare include proximity of neighboring carnivore species and placement of nest boxes. © 2010 Wiley-Liss, Inc.

  13. The nuts and bolts of curriculum and assessment.

    Science.gov (United States)

    Wehrli, Gay

    2011-01-01

    A curriculum is a planned educational experience. This broad definition includes everything from a single didactic lecture to a rotation or clerkship to an entire training program such as an internship, residency or fellowship. This guide is a six-step approach for creating any of these curricula. Steps 1 through 6 include: (1) identify the problem, (2) perform a needs assessment, (3) create goals and objectives, (4) develop the program, (5) implement the program, and (6) evaluate participants and the program. Use of these steps may at first seem laborious, yet results are user friendly and simplify subsequent curricula updating. Education accrediting agencies are increasing their expectations for detailed curricula and evaluations. This approach helps meet these standards. Copyright © 2010 Wiley-Liss, Inc.

  14. Mutual benefits of research collaborations between zoos and academic institutions.

    Science.gov (United States)

    Fernandez, Eduardo J; Timberlake, William

    2008-11-01

    Zoos focus on welfare, conservation, education, and research related to animals they keep. Academic institutions emphasize description, experimentation, modeling, and teaching of general and specific animal biology and behavior through work in both laboratory and field. The considerable overlap in concerns and methods has increased interest in collaborative projects, but there is ample room for closer and more extensive interactions. The purpose of this article is to increase awareness of potential research collaborations in three areas: (1) control and analysis of behavior, (2) conservation and propagation of species, and (3) education of students and the general public. In each area, we outline (a) research in zoos, (b) research in academics, and (c) potential collaborative efforts. Zoo Biol 27:470-487, 2008. (c) 2008 Wiley-Liss, Inc.

  15. The future of zoo biology.

    Science.gov (United States)

    Wharton, Dan

    2008-11-01

    The science of zoo biology and the journal of the same name are appropriately perceived as central to the issues that zoological gardens must address in managing large collections of hundreds of different species of animals. However, zoos are also cultural institutions that are seeking relevance in wildlife conservation by reaching out to their enormous audiences collectively numbered in the hundreds of millions worldwide. This article suggests that if zoos are to be effective in realizing significant conservation outcomes, they will need to engage the much broader range of sciences in developing institutionally compatible conservation agendas that do not rest on untested assumptions. Some of the research questions that zoos might ask themselves are provided as examples. Zoo Biol 27:498-504, 2008. (c) 2008 Wiley-Liss, Inc.

  16. Endogenous adipose tissue as a hemostatic: use in microsurgery.

    Science.gov (United States)

    Akelina, Yelena; Danilo, Peter

    2008-01-01

    Bleeding is a frequent complication of microsurgical repair of small blood vessels and time is spent while hemostasis is accomplished. We studied the hemostatic effect of endogenous adipose tissue on bleeding from rat femoral arterial anastomoses. We measured bleeding time (time from removal of clamps to cessation of active bleeding) and mean arterial blood velocity (using a micro-Doppler system), the latter immediately after anastomosis, and again 7 days post-anastomosis. Bleeding time for vessels with fat applied to the artery was 50% less than when no fat was applied. Blood velocity by day 7 post-anastomosis returned to values equivalent to those for intact arteries. Histological evaluation of the anastomotic site demonstrated no significant differences in inflammatory response between fat-treated and untreated arteries. These data suggest that endogenous adipose tissue may be a useful hemostatic agent devoid of significant effects on small artery blood velocity or histology. (c) 2008 Wiley-Liss, Inc.

  17. Leukocyte adhesion deficiency (LAD) type II/carbohydrate deficient glycoprotein (CDG) IIc founder effect and genotype/phenotype correlation.

    Science.gov (United States)

    Etzioni, Amos; Sturla, Laura; Antonellis, Anthony; Green, Eric D; Gershoni-Baruch, Ruth; Berninsone, Patricia M; Hirschberg, Carlos B; Tonetti, Michela

    2002-06-15

    Leukocyte adhesion deficiency (LAD) type II is a rare autosomal recessive syndrome characterized by recurrent infections, typical dysmorphic features, the Bombay blood phenotype and severe growth and psychomotor retardation. It is attributed to a general absence of fucosylated glycans on the cell surface. Three Arab Israeli patients and one Turkish child have been reported so far. The primary defect in a specific GDP-L-fucose transporter of the Golgi apparatus has been disclosed recently. All three children reported by us are homozygous for one single founder mutation, different from that reported in the Turkish child. The amount of mRNA of the GDP-L-fucose transporter in cells from Arab patients and their parents are comparable to controls. Genotype/phenotype correlation studies show that the two different mutations are distinguished by differences in response to fucose supplementation and in the clinical phenotypes. Copyright 2002 Wiley-Liss, Inc.

  18. Second primary cancers after anogenital, skin, oral, esophageal and rectal cancers: etiological links?

    Science.gov (United States)

    Hemminki, K; Jiang, Y; Dong, C

    2001-07-15

    The Swedish Family-Cancer Database was used to analyze second cancers after oral, esophageal, rectal, cervical, genital and skin (squamous cell carcinoma) cancers. A strong and consistent association of second cancers was observed at all these sites, in men and women. As a novel finding, an association of rectal cancer with the human papillomavirus (HVP)-related cancers was shown. New evidence on an excess of skin cancer with the HPV-related cancers was also provided. As an epidemiological study, the associations were strong and often supported by a number of comparisons. These could not be explained by bias or long-term treatment related effects. However, whether the findings on rectal and skin cancer are due to HPV or other infections, transient or inherited depressed immune function or other constitutional factors remains to be established. Copyright 2001 Wiley-Liss, Inc.

  19. Molecular bases of myelodysplastic syndromes: lessons from animal models.

    Science.gov (United States)

    Komeno, Yukiko; Kitaura, Jiro; Kitamura, Toshio

    2009-06-01

    Myelodysplastic syndrome (MDS) is a clonal disorder of hematopietic stem cells characterized by ineffective hematopoiesis, peripheral blood cytopenia, morphologic dysplasia, and susceptibility to acute myeloid leukemia. Several mechanisms have been suggested as causes of MDS: unbalanced chromosomal abnormalities reflecting a gain or loss of chromosomal material, point mutations of transcription factors, and inactivation of p53. However, appropriate animal models that mimic MDS have long been lacking. We recently reported a novel murine model of MDS that recapitulates trilineage dysplasia and transformation to AML. In this review, we summarize the animal models of MDS and discuss the molecular bases of MDS as well as those of leukemia and myeloproliferative disorders (MPD). J. Cell. Physiol. 219: 529-534, 2009. (c) 2009 Wiley-Liss, Inc.

  20. Xenopus pancreas development.

    Science.gov (United States)

    Pearl, Esther J; Bilogan, Cassandra K; Mukhi, Sandeep; Brown, Donald D; Horb, Marko E

    2009-06-01

    Understanding how the pancreas develops is vital to finding new treatments for a range of pancreatic diseases, including diabetes and pancreatic cancer. Xenopus is a relatively new model organism for the elucidation of pancreas development, and has already made contributions to the field. Recent studies have shown benefits of using Xenopus for understanding both early patterning and lineage specification aspects of pancreas organogenesis. This review focuses specifically on Xenopus pancreas development, and covers events from the end of gastrulation, when regional specification of the endoderm is occurring, right through metamorphosis, when the mature pancreas is fully formed. We have attempted to cover pancreas development in Xenopus comprehensively enough to assist newcomers to the field and also to enable those studying pancreas development in other model organisms to better place the results from Xenopus research into the context of the field in general and their studies specifically. Developmental Dynamics 238:1271-1286, 2009. (c) 2009 Wiley-Liss, Inc.

  1. A GIS based hydrogeomorphic approach for identification of site-specific artificial-recharge techniques in the Deccan Volcanic Province

    Indian Academy of Sciences (India)

    M N Ravi Shankar; G Mohan

    2005-10-01

    The Deccan Volcanic Province (DVP)of India,as a whole,faces a severe shortage of water despite receiving a high annual rainfall,this is primarily due to excess runoff and lack of water conservation practices.In this study,an attempt is made to identify zones favourable for the application and adaptation of site-specific artificial-recharge techniques for augmentation of groundwater through a Geographical Information System (GIS)based hydrogeomorphic approach in the Bhatsa and Kalu river basins of Thane district,in western DVP.The criteria adopted for the GIS analysis were based on the hydrogeomorphological characteristics of both basins extracted from the IRS- 1C LISS-III data supported by information on drainage pattern,DEM derived slope,lineament density,drainage density,and groundwater condition.The integrated study helps design a suitable groundwater management plan for a basaltic terrain.

  2. Fine-needle aspiration cytology of mammary fibroadenoma: a comparison of ThinPrep® and cytospin preparations.

    Science.gov (United States)

    Ly, Thai Yen; Barnes, Penny J; Macintosh, Rebecca F

    2011-03-01

    Mammary fibroadenoma (FA) is a lesion frequently sampled and diagnosed by fine-needle aspiration (FNA). Accurate cytologic diagnosis of this common benign lesion is important as this can lead to non-surgical, conservative management when breast imaging and clinical examination are concordant. In most instances, a confident diagnosis of FA is possible because of a characteristic cytologic appearance that includes hypercellularity, large epithelial cell groups, staghorn epithelial configurations, stromal fragments, and numerous background stripped nuclei. Nevertheless, FAs can be diagnostically challenging because of shared cytomorphologic features with other benign lesions and low-grade carcinoma. As such, FA is a well-recognized source of false results on FNA cytology. Furthermore, there are reports that newer thin layer cytopreparatory techniques, including the ThinPrep® (TP) system (Hologic Corp., Bedford, MA), alter the appearance of FA on FNA compared to conventional preparations and may compromise accurate cytologic diagnosis. Copyright © 2010 Wiley-Liss, Inc.

  3. Update from the 7th annual meeting of the Italian Society of Virology.

    Science.gov (United States)

    Salata, Cristiano; Calistri, Arianna; Palù, Giorgio

    2008-07-01

    The Italian Society of Virology (SIV) held a meeting in Orvieto (June 24-26, 2007) aimed at promoting interactions and collaborations between scientists in the field of Virology. The meeting had an attendance of about 170 virologists from Italy. In accordance with the normal format of the SIV National Meeting the conference transcended all areas of Virology. Sessions included invited speakers together with selected oral presentation. Covered topics included: General Virology and Viral Genetics, Medical Virology and Antiviral Therapy, Viral Biotechnologies and Gene Therapy, Viral Oncogenesis and Vaccines, Virus-Host Interactions and Pathogenesis, Emerging and Zoonotic Viral Infections. In this edition, a special effort was addressed to the HPV infection and prevention and to the guidelines for the preemptive (presymptomatic) therapy of human cytomegalovirus infections in transplant recipients. A summary of the main topics are reported. (c) 2008 Wiley-Liss, Inc.

  4. News and views from the 8th annual meeting of the Italian Society of Virology.

    Science.gov (United States)

    Sartori, Elena; Salata, Cristiano; Calistri, Arianna; Palù, Giorgio; Parolin, Cristina

    2009-06-01

    The 8th annual meeting of the Italian Society of Virology (SIV) took place in Orvieto, Italy from the 21st to the 23rd of September 2008. The meeting covered different areas of Virology and the scientific sessions focused on: general virology and viral genetics; viral oncology, virus-host interaction and pathogenesis; emerging viruses and zoonotic, foodborne and environmental pathways of transmission; viral immunology and vaccines; viral biotechnologies and gene therapy; medical virology and antiviral therapy. The meeting had an attendance of about 160 virologists from all Italy. In this edition, a satellite workshop on "Viral biotechnologies" was organized in order to promote the role of virologists in the biotechnological research and teaching fields. A summary of the plenary lectures and oral selected presentations is reported. J. Cell. Physiol. 219: 797-799, 2009. (c) 2009 Wiley-Liss, Inc.

  5. Metastatic melanoma of the heart.

    Science.gov (United States)

    Savoia, P; Fierro, M T; Zaccagna, A; Bernengo, M G

    2000-11-01

    Malignant melanoma has an unpredictable biologic behavior and is the neoplasm with the greatest propensity for cardiac involvement. Although relatively frequent at autopsy, cardiac metastases are rarely identified antemortem. We reviewed 2,810 patients with histologically confirmed malignant melanoma, who were diagnosed and followed up by our clinic. Clinical, histological, and imaging data are presented. Five cases of metastatic melanoma of the heart were identified out of 314 melanoma patients with visceral involvement. One case of a 53-year-old woman, who died unexpectedly during her first chemotherapy course, is described in detail. Postmortem examination determined the cause of death to be the presence of multiple melanoma metastases in the heart, even though the patient had shown no signs of cardiac involvement. The unpredictable biologic behavior of melanoma may lead to unusual metastatic sites, and, therefore, the heart also should be included in routine examinations. Copyright 2000 Wiley-Liss, Inc.

  6. Neurophysiologic correlates of fMRI in human motor cortex.

    Science.gov (United States)

    Hermes, Dora; Miller, Kai J; Vansteensel, Mariska J; Aarnoutse, Erik J; Leijten, Frans S S; Ramsey, Nick F

    2012-07-01

    The neurophysiological underpinnings of functional magnetic resonance imaging (fMRI) are not well understood. To understand the relationship between the fMRI blood oxygen level dependent (BOLD) signal and neurophysiology across large areas of cortex, we compared task related BOLD change during simple finger movement to brain surface electric potentials measured on a similar spatial scale using electrocorticography (ECoG). We found that spectral power increases in high frequencies (65-95 Hz), which have been related to local neuronal activity, colocalized with spatially focal BOLD peaks on primary sensorimotor areas. Independent of high frequencies, decreases in low frequency rhythms (neurophysiological mechanisms, one being spatially focal neuronal processing and the other spatially distributed low frequency rhythms. Copyright © 2011 Wiley-Liss, Inc.

  7. The neuroarchitecture of the circadian clock in the brain of Drosophila melanogaster.

    Science.gov (United States)

    Helfrich-Förster, Charlotte

    2003-10-01

    Neuroethologists try to assign behavioral functions to certain brain centers, if possible down to individual neurons and to the expression of specific genes. This approach has been successfully applied for the control of circadian rhythmic behavior in the fruit fly Drosophila melanogaster. Several so-called "clock genes" are expressed in specific neurons in the lateral and dorsal brain where they generate cell-autonomous molecular circadian oscillations. These clusters are connected with each other and contribute differentially to the control of behavioral rhythmicity. This report reviews the latest work on characterizing individual circadian pacemaker neurons in the fruit fly's brain that control activity and pupal eclosion, leading to the questions by which neuronal pathways they are synchronized to the external light-dark cycle, and how they impose periodicity on behavior. Copyright 2003 Wiley-Liss, Inc.

  8. Nikola Tesla: the man behind the magnetic field unit.

    Science.gov (United States)

    Roguin, Ariel

    2004-03-01

    The magnetic field strength of both the magnet and gradient coils used in MR imaging equipment is measured in Tesla units, which are named for Nikola Tesla. This article presents the life and achievements of this Serbian-American inventor and researcher who discovered the rotating magnetic field, the basis of most alternating-current machinery. Nikola Tesla had 700 patents in the United States and Europe that covered every aspect of science and technology. Tesla's discoveries include the Tesla coil, AC electrical conduction, improved lighting, newer forms of turbine engines, robotics, fluorescent light, wireless transmission of electrical energy, radio, remote control, discovery of cosmic radio waves, and the use of the ionosphere for scientific purposes. He was a genius whose discoveries had a pivotal role in advancing us into the modern era. Copyright 2004 Wiley-Liss, Inc.

  9. Cell biological regulation of division fate in vertebrate neuroepithelial cells.

    Science.gov (United States)

    Willardsen, Minde I; Link, Brian A

    2011-08-01

    The developing nervous system derives from neuroepithelial progenitor cells that divide to generate all of the mature neuronal types. For the proper complement of cell types to form, the progenitors must produce postmitotic cells, yet also replenish the progenitor pool. Progenitor divisions can be classified into three general types: symmetric proliferative (producing two progenitors), asymmetric neurogenic (producing one progenitor and one postmitotic cell), and symmetric neurogenic (producing two postmitotic cells). The appropriate ratios for these modes of cell division require intrinsic polarity, which is one of the characteristics that define neuroepithelial progenitor cells. The type of division an individual progenitor undergoes can be influenced by cellular features, or behaviors, which are heterogeneous within the population of progenitors. Here we review three key cellular parameters, asymmetric inheritance, cell cycle kinetics, and interkinetic nuclear migration, and the possible mechanisms for how these features influence progenitor fates. Copyright © 2011 Wiley-Liss, Inc.

  10. Geographic distribution and abundance of woolly (Lagothrix cana) and spider (Ateles chamek) monkeys in southwestern Brazilian Amazonia.

    Science.gov (United States)

    Iwanaga, Simone; Ferrari, Stephen F

    2002-01-01

    Two species of frugivorous atelids, Ateles chamek and Lagothrix cana, occur in southwestern Brazilian Amazonia. Populations were surveyed at 36 sites in the state of Rondônia. Ateles chamek is widespread, but the distribution of L. cana is limited by a combination of riverine barriers and ecological factors, possibly including competition with A. chamek. Groups of L. cana were generally larger and more abundant than those of A. chamek, even in syntopy. The transitional forest that predominates in the extreme south of Rondônia (Hylea-cerrado) is not a barrier to either species, with both species being tolerant of habitat disturbance when hunting pressure is low. Copyright 2002 Wiley-Liss, Inc.

  11. A scoring system for coat and tail condition in ringtailed lemurs, Lemur catta.

    Science.gov (United States)

    Berg, Wiebke; Jolly, Alison; Rambeloarivony, Hajarimanitra; Andrianome, Vonjy; Rasamimanana, Hantanirina

    2009-03-01

    Coat condition can be influenced by a wide variety of disorders and thus provides a useful tool for noninvasive health and welfare assessments in wild and captive animals. Using Lemur catta as an exemplar, we offer a 6-step scoring system for coat and tail condition, ranging from perfectly fluffy to half or more of body and tail being hairless. The categories are described in detail and illustrated with sample pictures from a wild population in Berenty Reserve, Madagascar. Furthermore, we elaborate on intermediate conditions and discoloration of fur. Coat condition scoring allows the comparison between years, seasons, and the effect of toxin, disease or stress. Although this system was developed for wild L. catta, we believe it can also be of value for other species. We recommend scoring coat condition in healthy wild mammal populations to give a baseline on yearly and seasonal variations vs. deteriorating health conditions or pathology. (c) 2009 Wiley-Liss, Inc.

  12. Intraspecific variation in hair delta(13)C and delta(15)N values of ring-tailed lemurs (Lemur catta) with known individual histories, behavior, and feeding ecology.

    Science.gov (United States)

    Loudon, James E; Sponheimer, Matt; Sauther, Michelle L; Cuozzo, Frank P

    2007-07-01

    Stable carbon and nitrogen isotope compositions were analyzed from hair samples of 30 sympatric ring-tailed lemurs (Lemur catta) inhabiting the Beza Mahafaly Special Reserve, Madagascar. All lemurs were known individuals involved in a longitudinal study, which allowed us to explore the degree to which group membership, sex, health status, and migration influenced their stable isotope compositions. The differences in delta(13)C and delta(15)N values between groups were small (lemur conservation. There were few sex differences, but significant differences did occur between individuals of normal and suboptimal health, with those in poor health (especially those in the worst condition) being enriched in (15)N and to a lesser degree (13)C compared with healthy individuals. Moreover, lemurs that had emigrated between 2003 and 2004 had different delta(13)C and delta(15)N compositions than their original groups. (c) 2007 Wiley-Liss, Inc.

  13. Nephrogenic systemic fibrosis versus contrast-induced nephropathy: risks and benefits of contrast-enhanced MR and CT in renally impaired patients

    DEFF Research Database (Denmark)

    Martin, Diego R; Semelka, Richard C; Chapman, Arlene;

    2009-01-01

    -sectional imaging modality. Factors to consider include the relative risks of the contrast agent. Other factors include the relative procedural risks, including radiation risks and the relative expected diagnostic yield of the examination technique (12). In this review we describe both nephrogenic systemic fibrosis...... and contrast-induced nephropathy to compare the implications with regard to relative risks and benefits of contrast-enhanced MRI or CT in patients with impaired renal function. J. Magn. Reson. Imaging 2009;30:1350-1356. (c) 2009 Wiley-Liss, Inc.......Magnetic resonance imaging (MRI) and computed tomography (CT) have become essential to diagnostic evaluation of many, or most, important medically and surgically treated diseases. It is important to consider comprehensively the implications in making decisions when choosing one or the other cross...

  14. Stereoselective degradation of metalaxyl and metalaxyl-M in soil and sunflower plants.

    Science.gov (United States)

    Marucchini, Cesare; Zadra, C

    2002-01-01

    A high proportion of agrochemicals are chiral compounds. Since stereoisomers often show different biological and physiological properties, the biological and metabolic responses to these compounds and their fate in the environment are expected to be different. In this work we investigate a possible stereo and/or enantioselective degradation in soil and plants (sunflower) of the fungicide Metalaxyl (rac-Metalaxyl) and the new compound Metalaxyl-M ((-)-(R)-Metalaxyl) and propose procedures for extraction, cleanup, chromatographic separation of enantiomers, and determination of the R : S ratio by using an HPLC chiral column. The degradation of the two stereoisomers of Metalaxyl proved to be enantioselective and dependent on the media: the (+)-(S)-enantiomer showed a faster degradation in plants, while the (-)-(R)-enantiomer showed a faster degradation in soil. In this study there was no evidence that racemization of Metalaxyl-M took place either in soil or in sunflowers. Copyright 2002 Wiley-Liss, Inc.

  15. IVIVC in oral absorption for fenofibrate immediate release tablets using a dissolution/permeation system.

    Science.gov (United States)

    Buch, Philipp; Langguth, Peter; Kataoka, Makoto; Yamashita, Shinji

    2009-06-01

    The usefulness of a dissolution/permeation (D/P) system to predict the in vivo performance of solid dosage forms containing the poorly soluble drug, fenofibrate, was studied. Biorelevant dissolution media simulating the fasted and fed state conditions of the human gastrointestinal tract were used in order to simulate the effect of food on the absorption of fenofibrate. Moreover, the results obtained from the D/P system were correlated with pharmacokinetic parameters obtained following in vivo studies in rats. The in vitro parameter (amount permeated in the D/P system) reflected well the in vivo performance in rats in terms of AUC and C(max) of fenofibric acid. This study thus demonstrates the potential of the D/P system as valuable tool for absorption screening of dosage forms for poorly soluble drugs. (c) 2008 Wiley-Liss, Inc.

  16. Analysis of recent incidents of on-field violence in sport: legal decisions and additional considerations from psychology.

    Science.gov (United States)

    Kerr, John H

    2009-01-01

    This article focuses on two recent incidents of serious on-field violence in sports and the legal consequences for those involved. The two incidents occurred in Dutch football (soccer) and became infamous owing to the nature of the violent incidents and widespread media coverage. The legal outcomes of these two incidents are described, and some of the difficulties that legal authorities face in considering assaults on the sports field are discussed. A new way of categorizing such violent incidents and the motivation behind them, based on an established psychological theory [reversal theory, Apter, 1982, 2001] is proposed. Taken along with the other points made in this article, being aware of when and how individuals cross the boundaries between play and anger, power or thrill violence may provide an additional perspective to making informed decisions about illegal violent acts on the sports field. Copyright 2008 Wiley-Liss, Inc.

  17. Single-molecule imaging of protein adsorption mechanisms to surfaces.

    Science.gov (United States)

    Zareh, Shannon Kian; Wang, Yan Mei

    2011-07-01

    Protein-surface interactions cause the desirable effect of controlled protein adsorption onto biodevices as well as the undesirable effect of protein fouling. The key to controlling protein-surface adsorptions is to identify and quantify the main adsorption mechanisms: adsorptions that occur (1) while depositing a protein solution onto dry surfaces and (2) after the deposition onto wet surfaces. Bulk measurements cannot reveal the dynamic protein adsorption pathways and thus cannot differentiate between the two adsorption mechanisms. We imaged the interactions of single streptavidin molecules with hydrophobic fused-silica surfaces in real-time. We observed both adsorbed proteins on surfaces and diffusing proteins near surfaces and analyzed their adsorption kinetics. Our analysis shows that the protein solution deposition process is the primary mechanism of streptavidin adsorption onto surfaces at the subnanomolar to nanomolar protein concentrations. Furthermore, we found that hydrophilic fused-silica surfaces can prevent the adsorption of streptavidin molecules. Copyright © 2010 Wiley-Liss, Inc.

  18. Moving up the slippery slope: mandated genetic screening on Cyprus.

    Science.gov (United States)

    Cowan, Ruth Schwartz

    2009-02-15

    Many social scientists and bioethicists have argued that genetic screening is a new form of eugenics. Examination of the development of the quasi-mandated screening program for beta-thalassemia in the Republic of Cyprus (1970-1984) demonstrates that there is nothing eugenic about modern genetic screening practices. The Cypriot screening program involves mandated premarital carrier screening, voluntary prenatal diagnosis (originally through fetoscopy, now through CVS), and voluntary termination of afflicted pregnancies-all at public expense. In the Republic of Cyprus, the mandating agency for genetic screening is the established church, so this examination also demonstrates that religious authorities with profound objections to abortion can balance that moral precept against others, such as the imperative to reduce suffering that sometimes conflict with it. (c) 2009 Wiley-Liss, Inc.

  19. The pedigree tool: web-based visualization of a family tree.

    Science.gov (United States)

    Lachmund, Peter; Nebel, Istvan-Tibor; Führer, Dagmar; Paschke, Ralf

    2004-02-01

    We describe the development of a novel tool that facilitates the design and visualization of pedigrees using a special Internet application. The tool is programmed in Java, using a PHP script as an interface. This web-based tool is used to generate, edit, and/or view pedigrees. The advantage of our novel tool is that it is based on a notation that allows the representation of any given number of generations, family members per generation, and multiple clinical or genetic features of an individual family member. In addition, the notation allows us to minimize the storage space by 100% to 500% and to standardize the presentation of family trees and segregation analysis for inheritance of mendelian disorders or even complex traits. This pedigree tool has been implemented with a database of thyroid-stimulating hormone receptor (TSHR) mutations (http://www.uni-leipzig.de/innere/tshr/). Copyright 2003 Wiley-Liss, Inc.

  20. Characterization of the residual structure in the unfolded state of the Delta 131 Delta fragment of staphylococcal nuclease

    DEFF Research Database (Denmark)

    Francis, C. J.; Lindorff-Larsen, Kresten; Best, R. B.;

    2006-01-01

    The determination of the conformational preferences in unfolded states of proteins constitutes an important challenge in structural biology. We use inter-residue distances estimated from site-directed spin-labeling NMR experimental measurements as ensemble-averaged restraints in all-atom molecular...... dynamics simulations to characterise the residual structure of the 131 fragment of staphylococcal nuclease under physiological conditions. Our findings indicate that 131 under these conditions shows a tendency to form transiently hydrophobic clusters similar to those present in the native state of wild......-type staphylococcal nuclease. Only rarely, however, all these interactions are simultaneously realized to generate conformations with an overall native topology. Proteins 2006. © 2006 Wiley-Liss, Inc....

  1. Factor V Leiden associated with flap loss in microsurgical breast reconstruction.

    Science.gov (United States)

    Khansa, Ibrahim; Colakoglu, Salih; Tomich, David C; Nguyen, Minh-Doan; Lee, Bernard T

    2011-07-01

    Two cases are reported of flap loss following microsurgical perforator flap breast reconstruction in patients diagnosed with a factor V Leiden mutation. Factor V Leiden is the most common inherited cause of hypercoagulability, leading to an increased risk of thrombotic events. The first patient underwent a deep inferior epigastric artery perforator flap and then had recurrent arterial thrombosis both intraoperatively and postoperatively. This patient was subsequently diagnosed with a factor V Leiden mutation. The second patient had a known factor V Leiden mutation and underwent a superior gluteal artery perforator flap, which developed thrombosis and flap loss 2 days later. Preoperative assessment of a personal or family history of unexplained venous or arterial thrombosis should prompt suspicion of a factor V Leiden mutation. This mutation places patients at high risk for thromboembolic events in microvascular breast reconstruction, particularly when oral contraceptives or tamoxifen are used in conjunction. Copyright © 2011 Wiley-Liss, Inc.

  2. Developments in treatment of anxiety disorders: psychotherapy, pharmacotherapy, and psychosurgery.

    Science.gov (United States)

    Balon, Richard

    2004-01-01

    A selection of articles that focus on psychosocial treatments, pharmacotherapy, and psychosurgery of anxiety disorders are reviewed. While some medications look clearly beneficial or potentially effective in the treatment of anxiety disorders, other compounds seem less promising or not effective. A combination of proven pharmacotherapies and psychotherapies may be the most clinically prudent approach to the treatment of anxiety disorders. Thermocapsulotomy may be an "extreme" option in selected cases of severe nonobsessive anxiety but may carry a significant risk of adverse effects indicative of frontal lobe functioning impairment. In spite of all the research and progress in studying relatively well-defined therapies, many patients suffering from anxiety and depression still use complementary and alternative therapies. The use of alternative and complementary is likely to increase as insurance coverage expands. Copyright 2004 Wiley-Liss, Inc.

  3. Understanding comorbidity: a twin study of reading disability and attention-deficit/hyperactivity disorder.

    Science.gov (United States)

    Willcutt, Erik G; Pennington, Bruce F; Olson, Richard K; DeFries, John C

    2007-09-05

    A community sample of twins in which at least one member of each pair exhibited significant reading difficulties (99 monozygotic and 80 dizygotic pairs) or symptoms of attention-deficit/hyperactivity disorder (ADHD; 83 monozygotic and 78 dizygotic pairs) was used to test the etiology of comorbidity between reading disability (RD) and ADHD. Univariate analyses revealed moderate to high heritability for all measures of reading difficulty and ADHD. Subsequent bivariate analyses indicated that the relation between reading difficulties and inattention symptoms is primarily attributable to common genetic influences, whereas bivariate heritability estimates were not significant for hyperactivity-impulsivity and any of the reading measures. Reading difficulties and ADHD symptoms were more highly heritable if the proband met criteria for both disorders versus RD or ADHD alone, suggesting that future molecular genetic analyses of comorbid RD + ADHD may facilitate the identification of susceptibility genes for RD, ADHD, and their comorbidity. Copyright 2007 Wiley-Liss, Inc.

  4. How to measure reproductive success?

    Science.gov (United States)

    Strassmann, Beverly I; Gillespie, Brenda

    2003-01-01

    To date there have been few empirical comparisons between alternative methods for measuring reproductive success (RS). We consider the pros and cons of alternative measures of RS to provide guidance for the design of field studies in human behavioral ecology. We compare cross-sectional measures that count offspring alive at the time of the interview and retrospective measures that require data on offspring age at death or censoring. We consider analyses that include adult women (yielding age-specific estimates of RS) as well as analyses restricted to postreproductive women (yielding data on lifetime RS). These methods are applied to reproductive data for the Dogon of Mali, West Africa. Copyright 2003 Wiley-Liss, Inc.

  5. Highlights from the 5th Annual Meeting of the Italian Society of Virology.

    Science.gov (United States)

    Salata, Cristiano; Calistri, Arianna; Palù, Giorgio

    2006-07-01

    The 5th National Congress of the Italian Society of Virology (SIV) was attended by junior- and senior-level virologists to promote interactions and scientific collaborations among the different areas of Virology and allied sciences. The invited and selected lecturers covered the following topics: General Virology and Viral Genetics; Virus-host Interaction and Pathogenesis; Viral Oncogenesis; Viral Immunology and Vaccines; Anti-viral Therapy; Innovative Diagnostics; Viral Biotechnologies and Cell and Gene Therapy. As in the previous editions (Salata and Palù, 2004; Salata et al., 2005), a specific topic was thoroughly covered in a roundtable. This year the elected subject was "HIV: determinants of pathogenicity and clinical implications." The final program and the abstract book can be found at the web site http://www.siv-virologia.it. This report summarizes the lessons learned from the plenary lectures and the selected oral presentations of the 2005 meeting. Copyright 2006 Wiley-Liss, Inc.

  6. Gap junction diseases of the skin.

    Science.gov (United States)

    van Steensel, M A M

    2004-11-15

    Gap junctions are intercellular channels that allow the passage of water, ions, and small molecules. They are involved in quick, short-range messaging between cells and are found in skin, nervous tissue, heart, and muscle. An increasing number of hereditary skin disorders appear to be caused by mutations in one of the genes coding for the constituent proteins of gap junctions, known as connexins. In this review, the currently known connexin disorders that feature skin abnormalities are described: keratitis-ichthyosis deafness syndrome, erythrokeratoderma variabilis, Vohwinkel's syndrome, and a novel disorder called hypotrichosis-deafness syndrome. What is known about the pathogenesis of these disorders is discussed and related to gap junction physiology. (c) 2004 Wiley-Liss, Inc.

  7. One year follow-up of children and adolescents with chronic immune thrombocytopenic purpura (ITP) treated with rituximab.

    Science.gov (United States)

    Mueller, Brigitta U; Bennett, Carolyn M; Feldman, Henry A; Bussel, James B; Abshire, Thomas C; Moore, Theodore B; Sawaf, Hadi; Loh, Mignon L; Rogers, Zora R; Glader, Bertil E; McCarthy, Maggie C; Mahoney, Donald H; Olson, Thomas A; Feig, Stephen A; Lorenzana, Adonis N; Mentzer, William C; Buchanan, George R; Neufeld, Ellis J

    2009-02-01

    We previously showed in a prospective study that rituximab appears to be effective in some children and adolescents with severe chronic immune thrombocytopenia. Eleven of 36 patients achieved and maintained platelet counts over 50,000/mm(3) within the first 12 weeks. These patients were followed for the next year. Platelet counts were monitored monthly and all subsequent bleeding manifestations and need for further treatment was noted. Eight of the 11 initial responders maintained a platelet count over 150,000/mm(3) without further treatment intervention. Three patients had a late relapse. One initial non-responder achieved a remission after 16 weeks, and two additional patients maintained platelet counts around 50,000/mm(3) without the need for further intervention. Rituximab resulted in sustained efficacy with platelet counts of 50,000/mm(3) or higher in 11 of 36 patients (31%). (c) 2008 Wiley-Liss, Inc.

  8. Magnetic microparticle aggregation for viscosity determination by MR.

    Science.gov (United States)

    Hong, Rui; Cima, Michael J; Weissleder, Ralph; Josephson, Lee

    2008-03-01

    Micron-sized magnetic particles were induced to aggregate when placed in homogeneous magnetic fields, like those of MR imagers and relaxometers, and then spontaneously returned to their dispersed state when removed from the field. Associated with the aggregation and dispersion of the magnetic particles were time-dependent increases and decreases in the spin-spin relaxation time (T2) of the water. Magnetic nanoparticles, with far smaller magnetic moments per particle, did not undergo magnetically induced aggregation and exhibited time-independent values of T2. The rate of T2 change associated with magnetic microparticle aggregation was used to determine the viscosity of liquid samples, providing a method that can be of particular advantage for determining the viscosity of small volumes of potentially biohazardous samples of blood or blood plasma. (c) 2008 Wiley-Liss, Inc.

  9. Interleaved variable density sampling with a constrained parallel imaging reconstruction for dynamic contrast-enhanced MR angiography.

    Science.gov (United States)

    Wang, Kang; Busse, Reed F; Holmes, James H; Beatty, Philip J; Brittain, Jean H; Francois, Christopher J; Reeder, Scott B; Du, Jiang; Korosec, Frank R

    2011-08-01

    For MR applications such as contrast-enhanced MR angiography, it is desirable to achieve simultaneously high spatial and temporal resolution. The current clinical standard uses view-sharing methods combined with parallel imaging; however, this approach still provides limited spatial and temporal resolution. To improve on the clinical standard, we present an interleaved variable density (IVD) sampling method that pseudorandomly undersamples each individual frame of a 3D Cartesian ky-kz plane combined with parallel imaging acceleration. From this dataset, time-resolved images are reconstructed with a method that combines parallel imaging with a multiplicative constraint. Total acceleration factors on the order of 20 are achieved for contrast-enhanced MR angiography of the lower extremities, and improvements in temporal fidelity of the depiction of the contrast bolus passage are demonstrated relative to the clinical standard. Copyright © 2011 Wiley-Liss, Inc.

  10. On the age of the hominid fossils at the Sima de los Huesos, Sierra de Atapuerca, Spain: paleomagnetic evidence.

    Science.gov (United States)

    Parés, J M; Pérez-González, A; Weil, A B; Arsuaga, J L

    2000-04-01

    We report new paleomagnetic data for the Middle Pleistocene hominid-bearing strata in the Sima de los Huesos, North Spain. Sediments (brown muds with human and bear fossils and the underlying sterile clayey and sandy unit) preserve both normal and reversed magnetic components. The sterile unit has exclusively reversed magnetization, dating back to the Matuyama Chron, and thus is Lower Pleistocene in age. The overlying fossiliferous muds have a dominant normal magnetization that overprints a partially resolved reversed magnetization. These data are compatible with one of the reversal events that occurred during the Brunhes Chron. Combined with the existing U-series dates and evidence from the macro- and microfauna, these paleomagnetic results suggest an age of the hominid fossils between 325 to 205 ka, whereas the underlying sand and silts are older than 780 ka. Copyright 2000 Wiley-Liss, Inc.

  11. Pattern of dental development in Hominid XVIII from the Middle Pleistocene Atapuerca-Sima de los Huesos site (Spain).

    Science.gov (United States)

    Bermudez De Castro, J M; Rosas, A

    2001-04-01

    . We describe the pattern of dental development of Hominid XVIII from the Middle Pleistocene Sima de los Huesos (SH) site of the Sierra de Atapuerca (Burgos, Spain). As expected, this pattern is similar to that of modern humans. A delay of development of the lower and upper canines was observed. In contrast, the relative advanced development of the lower second molars and, especially, the upper and lower third molars is noteworthy. This latter feature seems to be common in Pleistocene hominids, and suggests that the pattern of dental development evolved in the genus Homo during the Pleistocene. In European Middle Pleistocene hominids, this pattern probably was facilitated by the extra space available in the mandible and maxilla for developing teeth. Copyright 2001 Wiley-Liss, Inc.

  12. Membrane vesicles containing matrix metalloproteinase-9 and fibroblast growth factor-2 are released into the extracellular space from mouse mesoangioblast stem cells.

    Science.gov (United States)

    Candela, Maria Elena; Geraci, Fabiana; Turturici, Giuseppina; Taverna, Simona; Albanese, Ida; Sconzo, Gabriella

    2010-07-01

    Certain proteins, including fibroblast growth factor-2 (FGF-2) and matrix metalloproteinase-9 (MMP-9), have proved very effective in increasing the efficacy of mesoangioblast stem cell therapy in repairing damaged tissue. We provide the first evidence that mouse mesoangioblast stem cells release FGF-2 and MMP-9 in their active form through the production of membrane vesicles. These vesicles are produced and turned over continuously, but are stable for some time in the extracellular milieu. Mesoangioblasts shed membrane vesicles even under oxygen tensions that are lower than those typically used for cell culture and more like those of mouse tissues. These findings suggest that mesoangioblasts may themselves secrete paracrine signals and factors that make damaged tissues more amenable to cell therapy through the release of membrane vesicles. (c) 2010 Wiley-Liss, Inc.

  13. Aspiration cytology of ameloblastic fibroma: a diagnostic challenge.

    Science.gov (United States)

    Kumar, Neeta; Jain, Shyama

    2003-08-01

    Ameloblastic fibroma of the jaw is a rare, benign mixed odontogenic tumor, having little tendency for local invasion and a low recurrence rate. Cytologic distinction from ameloblastoma, ameloblastic fibrosarcoma, and intraosseous adenoid cystic carcinoma is necessary, in view of the different biologic behavior. A painful, slow-growing swelling of the jaw in a 5-yr-old child clinicoradiologically considered as a benign cystic lesion was aspirated. Sheets of small monomorphic epithelial cells with peripheral palisading by columnar cells were seen on cytology smears. The striking feature was central hyaline globules in some tubules. A cytologic possibility of adenomatoid odontogenic tumor was suggested. Histopathology, however, confirmed it to be an ameloblastic fibroma. Copyright 2003 Wiley-Liss, Inc.

  14. Optically detunable, inductively coupled coil for self-gating in small animal magnetic resonance imaging.

    Science.gov (United States)

    Korn, Matthias; Umathum, Reiner; Schulz, Jessica; Semmler, Wolfhard; Bock, Michael

    2011-03-01

    An inductively coupled coil concept is presented, which improves the compensation of physiological motion by the self-gating (SG) technique. The animal is positioned in a conventional volume coil encompassing the whole animal. A small, resonant surface coil (SG-coil) is placed on the thorax so that its sensitive region includes the heart. Via inductive coupling the SG-coil amplifies selectively the MR signal of the beating heart. With an optical detuning mechanism, this coupling can be switched off during acquisition of the MR image information, whereas it is active during SG data sampling to provide the physiological information. In vivo experiments on a mouse show an amplification of the SG signal by at least 40%. Copyright © 2010 Wiley-Liss, Inc.

  15. 2000 Year-old ancient equids: an ancient-DNA lesson from pompeii remains.

    Science.gov (United States)

    Di Bernardo, Giovanni; Del Gaudio, Stefania; Galderisi, Umberto; Cipollaro, Marilena

    2004-11-15

    Ancient DNA extracted from 2000 year-old equine bones was examined in order to amplify mitochondrial and nuclear DNA fragments. A specific equine satellite-type sequence representing 3.7%-11% of the entire equine genome, proved to be a suitable target to address the question of the presence of aDNA in ancient bones. The PCR strategy designed to investigate this specific target also allowed us to calculate the molecular weight of amplifiable DNA fragments. Sequencing of a 370 bp DNA fragment of mitochondrial control region allowed the comparison of ancient DNA sequences with those of modern horses to assess their genetic relationship. The 16S rRNA mitochondrial gene was also examined to unravel the post-mortem base modification feature and to test the status of Pompeian equids taxon on the basis of a Mae III restriction site polymorphism. Copyright 2004 Wiley-Liss, Inc.

  16. Use of positive reinforcement conditioning to monitor pregnancy in an unanesthetized snow leopard (Uncia uncia) via transabdominal ultrasound.

    Science.gov (United States)

    Broder, Jacqueline M; Macfadden, Annabell J; Cosens, Lindsay M; Rosenstein, Diana S; Harrison, Tara M

    2008-01-01

    Closely monitoring snow leopard (Uncia uncia) fetal developments via transabdominal ultrasound, with minimal stress to the animal, was the goal of this project. The staff at Potter Park Zoo has used the principles of habituation, desensitization, and positive reinforcement to train a female snow leopard (U. uncia). Ultrasound examinations were preformed on an unanesthetized feline at 63 and 84 days. The animal remained calm and compliant throughout both procedures. Fetuses were observed and measured on both occasions. The absence of anesthesia eliminated components of psychologic and physiologic stress associated with sedation. This was the first recorded instance of transabdominal ultrasound being carried out on an unanesthetized snow leopard. It documents the feasibility of detecting pregnancy and monitoring fetal development via ultrasound. Zoo Biol 27:78-85, 2008. (c) 2007 Wiley-Liss, Inc.

  17. The Simpson-Golabi-Behmel syndrome: A clinical case and a detective story.

    Science.gov (United States)

    Gurrieri, F; Pomponi, M G; Pietrobono, R; Lucci-Cordisco, E; Silvestri, E; Storniello, G; Neri, G

    2011-01-01

    The Simpson-Golabi-Behmel syndrome (SGBS) is an overgrowth condition comprising "coarseness" of facial traits, supernumerary nipples, congenital heart defects, polydactyly and fingernail hypoplasia, and an increased risk of neonatal death and later neoplasia. Psychomotor development is usually normal. The syndrome is caused by mutation/deletion of the X-linked gene GPC3. We describe a new case of SGBS, that led to the discovery of an extended family segregating a GPC3 mutation and, ultimately, of an affected relative forgotten, but not lost, in an anatomical museum, where he was classified as a macrosomic newborn, who was born probably around 1940 and died neonatally of unknown cause. This baby boy becomes the oldest case of SGBS on record. Copyright © 2010 Wiley-Liss, Inc.

  18. Noise correction for the exact determination of apparent diffusion coefficients at low SNR.

    Science.gov (United States)

    Dietrich, O; Heiland, S; Sartor, K

    2001-03-01

    Noise in MR image data increases the mean signal intensity of image regions due to the usually performed magnitude reconstruction. Diffusion-weighted imaging (DWI) is especially affected by high noise levels for several reasons, and a decreasing SNR at increasing diffusion weighting causes systematic errors when calculating apparent diffusion coefficients (ADCs). Two different methods are presented to correct biased signal intensities due to the presence of complex noise: 1) with Gaussian intensity distribution, and 2) with arbitrary intensity distribution. The performance of the correction schemes is demonstrated by numerical simulations and DWI measurements on two different MR systems with different noise characteristics. These experiments show that noise significantly influences the determination of ADCs. Applying the proposed correction schemes reduced the bias of the determined ADC to less than 10% of the bias without correction. Magn Reson Med 45:448-453, 2001. Copyright 2001 Wiley-Liss, Inc.

  19. Dietary specialization and Eucalyptus species preferences in Queensland koalas (Phascolarctos cinereus).

    Science.gov (United States)

    Higgins, Alexis L; Bercovitch, Fred B; Tobey, Jennifer R; Andrus, Chris Hamlin

    2011-01-01

    Koalas specialize on Eucalyptus leaves, but also feed selectively. Food choice is not random, but depends on various factors that are not well understood, although most research has focused on the role of secondary plant compounds. We studied the feeding choices of four adult male koalas housed at the San Diego Zoo. All subjects had a choice of nine types of Eucalyptus leaves over the eight-week study. The most preferred species was E. camuldulensis, but individual males exhibited different feeding preferences. We conclude that food selectivity among koalas is probably due to multiple factors, rather than only a consequence of secondary plant chemicals. A combination of intrinsic factors, such as developmental trajectory and reproductive state, as well as extrinsic factors, such as leaf chemical fingerprint and moisture, probably interact to shape koala foraging preferences. Koalas forage almost exclusively on Eucalyptus species, but have evolved an adaptive flexibility, enabling them to exploit various Eucalyptus species. © 2010 Wiley-Liss, Inc.

  20. PERFORMANCE EVALUATION OF DISTANCE MEASURES IN PROPOSED FUZZY TEXTURE MODEL FOR LAND COVER CLASSIFICATION OF REMOTELY SENSED IMAGE

    Directory of Open Access Journals (Sweden)

    S. Jenicka

    2014-04-01

    Full Text Available Land cover classification is a vital application area in satellite image processing domain. Texture is a useful feature in land cover classification. The classification accuracy obtained always depends on the effectiveness of the texture model, distance measure and classification algorithm used. In this work, texture features are extracted using the proposed multivariate descriptor, MFTM/MVAR that uses Multivariate Fuzzy Texture Model (MFTM supplemented with Multivariate Variance (MVAR. The K_Nearest Neighbour (KNN algorithm is used for classification due to its simplicity coupled with efficiency. The distance measures such as Log likelihood, Manhattan, Chi squared, Kullback Leibler and Bhattacharyya were used and the experiments were conducted on IRS P6 LISS-IV data. The classified images were evaluated based on error matrix, classification accuracy and Kappa statistics. From the experiments, it is found that log likelihood distance with MFTM/MVAR descriptor and KNN classifier gives 95.29% classification accuracy.

  1. Pharmaco-genetically guided treatment of recurrent rage outbursts in an adult male with 15q13.3 deletion syndrome.

    Science.gov (United States)

    Cubells, Joseph F; Deoreo, Elizabeth H; Harvey, Philip D; Garlow, Steven J; Garber, Kathryn; Adam, Margaret P; Martin, Christa Lese

    2011-04-01

    15q13.3 deletion syndrome (15q13.3DS) is a common recurrent genomic disorder associated with epilepsy, intellectual impairment, aggressive behavior, schizophrenia, and autism. A 39-year-old male presented with 15q13.3DS, epilepsy, intellectual impairment, psychosis, and recurrent episodes of aggressive rage. We hypothesized that the patient's aggressive behavior reflected deficits in α7 nicotinic cholinergic receptor (NChR)-mediated neurotransmission, arising from haploinsufficiency of the structural gene CHRNA7 due to the deletion. Treatment with the NChR allosteric modulator and acetylcholinesterase (AChE) inhibitor, galantamine, led to a dramatic decline in the frequency and intensity of rage outbursts, suggesting that enhancement of α7 NChR function can ameliorate 15q13.3DS-associated rage outbursts. Copyright © 2011 Wiley-Liss, Inc.

  2. Majewski osteodysplastic primordial dwarfism type II (MOPD II) syndrome previously diagnosed as Seckel syndrome: report of a novel mutation of the PCNT gene.

    Science.gov (United States)

    Piane, Maria; Della Monica, Matteo; Piatelli, Gianluca; Lulli, Patrizia; Lonardo, Fortunato; Chessa, Luciana; Scarano, Gioacchino

    2009-11-01

    We report on a 3-year-old boy with prenatal onset of proportionate dwarfism, postnatal severe microcephaly, high forehead with receded hairline, sparse scalp hair, beaked nose, mild retrognathia and hypotonia diagnosed at birth as Seckel syndrome. At age 3 years, he became paralyzed due to a cerebrovascular malformation. Based on the clinical and radiological features showing evidence of skeletal dysplasia, the diagnosis was revised to Majewski osteodysplastic primordial dwarfism type II (MOPD II) syndrome. Western blot analysis of the patient's lymphoblastoid cell line lysate showed the absence of the protein pericentrin. Subsequent molecular analysis identified a novel homozygous single base insertion (c.1527_1528insA) in exon 10 of the PCNT gene, which leads to a frameshift (Treo510fs) and to premature protein truncation. PCNT mutations must be considered diagnostic of MOPD II syndrome. A possible role of pericentrin in the development of cerebral vessels is suggested. Copyright 2009 Wiley-Liss, Inc.

  3. Hazardous task recognition among U.S. adolescents working in the retail or service industry.

    Science.gov (United States)

    Vladutiu, Catherine J; Rauscher, Kimberly J; Runyan, Carol W; Schulman, Michael; Villaveces, Andrés

    2010-07-01

    Although the hazardous tasks adolescent workers perform in service and retail industries are well documented, little is known about the extent to which young workers recognize these tasks as hazardous or dangerous. Using data from a nationally representative cross-sectional telephone survey conducted in 2003, we examined hazardous task recognition among 858 adolescents working in the retail or service industry. Approximately 13% (n = 123) of respondents reported that they consider at least one of their job tasks to be hazardous or dangerous. Among the respondents who performed tasks known to be hazardous, very few actually recognized these tasks as being hazardous or dangerous. Working adolescents appear to underestimate the dangers associated with work, thus increasing the potential likelihood of injury. Emphasis should be placed on eliminating or reducing hazards in the workplace while simultaneously improving young workers' recognition of the hazardous nature of many of the tasks they perform. 2010 Wiley-Liss, Inc.

  4. Prospective linkages between peer victimization and externalizing problems in children: a meta-analysis.

    Science.gov (United States)

    Reijntjes, Albert; Kamphuis, Jan H; Prinzie, Peter; Boelen, Paul A; van der Schoot, Menno; Telch, Michael J

    2011-01-01

    Previous meta-analytic research has shown both concurrent and prospective linkages between peer victimization and internalizing problems in youth. However, the linkages between peer victimization and externalizing problems over time have not been systematically examined, and it is therefore unknown if externalizing problems are antecedents of victimization, consequences of victimization, both, or neither. This study provides a meta-analysis of 14 longitudinal studies examining prospective linkages between peer victimization and externalizing problems (n = 7,821). Two prospective paths were examined: the extent to which peer victimization at baseline predicts future residualized changes in externalizing problems, as well as the extent to which externalizing problems at baseline predict future residualized changes in peer victimization. Results revealed significant associations between peer victimization and subsequent residualized changes in externalizing problems, as well as significant associations between externalizing problems and subsequent residualized changes in peer victimization. Hence, externalizing problems function as both antecedents and consequences of peer victimization. © 2010 Wiley-Liss, Inc.

  5. Mechanisms of action of intravenous immunoglobulin in the treatment of immune thrombocytopenia.

    Science.gov (United States)

    Crow, Andrew R; Song, Seng; Siragam, Vinayakumar; Lazarus, Alan H

    2006-10-15

    Intravenous immunoglobulin (IVIG) is currently used to treat a multitude of autoimmune disorders including immune thrombocytopenic purpura (ITP), yet the mechanism of action of IVIG remains unresolved. Using a murine model of ITP in which IVIG functions therapeutically, our laboratory has addressed such theories as blockade/inhibition of the mononuclear phagocytic system, cytokine regulation, and neutralization of pathogenic autoantibodies mediated by anti-idiotypic antibodies, and these findings will be discussed herein. We have also demonstrated that soluble immune complexes can completely recapitulate the therapeutic effects of IVIG in ITP, and recent work from us has identified activating Fcgamma receptors on CD11c+ dendritic cells as the relevant molecular target of IVIG in the acute resolution of murine immune thrombocytopenia. This and other work to devise antibody-based IVIG alternative therapies will also be addressed. Copyright (c) 2006 Wiley-Liss, Inc.

  6. Informing the symptom profile of complicated grief.

    Science.gov (United States)

    Simon, Naomi M; Wall, Melanie M; Keshaviah, Aparna; Dryman, M Taylor; LeBlanc, Nicole J; Shear, M Katherine

    2011-02-01

    Complicated Grief (CG) is under consideration as a new diagnosis in DSM5. We sought to add empirical support to the current dialogue by examining the commonly used Inventory of Complicated Grief (ICG) scale completed by 782 bereaved individuals. We employed IRT analyses, factor analyses, and sensitivity and specificity analyses utilizing our full sample (n = 782), and also compared confirmed CG cases (n = 288) to noncases (n = 377). Confirmed CG cases were defined as individuals bereaved at least 6 months who were seeking care for CG, had an ICG ≥ 30, and received a structured clinical interview for CG by a certified clinician confirming CG as their primary illness. Noncases were bereaved individuals who did not present with CG as a primary complaint (including those with depression, bipolar disorder, anxiety disorders, and controls) and had an ICGDSM5 criteria for CG. © 2010 Wiley-Liss, Inc.

  7. Database of queryable gene expression patterns for Xenopus.

    Science.gov (United States)

    Gilchrist, Michael J; Christensen, Mikkel B; Bronchain, Odile; Brunet, Frédéric; Chesneau, Albert; Fenger, Ursula; Geach, Timothy J; Ironfield, Holly V; Kaya, Ferdinand; Kricha, Sadia; Lea, Robert; Massé, Karine; Néant, Isabelle; Paillard, Elodie; Parain, Karine; Perron, Muriel; Sinzelle, Ludivine; Souopgui, Jacob; Thuret, Raphaël; Ymlahi-Ouazzani, Qods; Pollet, Nicolas

    2009-06-01

    The precise localization of gene expression within the developing embryo, and how it changes over time, is one of the most important sources of information for elucidating gene function. As a searchable resource, this information has up until now been largely inaccessible to the Xenopus community. Here, we present a new database of Xenopus gene expression patterns, queryable by specific location or region in the embryo. Pattern matching can be driven either from an existing in situ image, or from a user-defined pattern based on development stage schematic diagrams. The data are derived from the work of a group of 21 Xenopus researchers over a period of 4 days. We used a novel, rapid manual annotation tool, XenMARK, which exploits the ability of the human brain to make the necessary distortions in transferring data from the in situ images to the standard schematic geometry. Developmental Dynamics 238:1379-1388, 2009. (c) 2009 Wiley-Liss, Inc.

  8. Pulsed electric field reduces the permeability of potato cell wall.

    Science.gov (United States)

    Galindo, Federico Gómez; Vernier, P Thomas; Dejmek, Petr; Vicente, António; Gundersen, Martin A

    2008-05-01

    The effect of the application of pulsed electric fields to potato tissue on the diffusion of the fluorescent dye FM1-43 through the cell wall was studied. Potato tissue was subjected to field strengths ranging from 30 to 500 V/cm, with one 1 ms rectangular pulse, before application of FM1-43 and microscopic examination. Our results show a slower diffusion of FM1-43 in the electropulsed tissue when compared with that in the non-pulsed tissue, suggesting that the electric field decreased the cell wall permeability. This is a fast response that is already detected within 30 s after the delivery of the electric field. This response was mimicked by exogenous H2O2 and blocked by sodium azide, an inhibitor of the production of H2O2 by peroxidases. (c) 2007 Wiley-Liss, Inc.

  9. Development of vacuum-ultraviolet circular dichroism measurement system using a polarizing undulator.

    Science.gov (United States)

    Tanaka, Masahito; Yagi-Watanabe, Kazutoshi; Yamada, Toru; Kaneko, Fusae; Nakagawa, Kazumichi

    2006-02-01

    We have developed an improved circular dichroism (CD) and linear dichroism (LD) simultaneous measurement system for the vacuum ultraviolet (VUV) region by polarization modulation techniques using a four-period Onuki-type crossed undulator as a polarized light source. The system has been constructed at the VUV beamline BL-5 in the electron storage ring TERAS, at AIST. Our improvements, in particular the adoption of an optical chopper as the detection method of incident light, have resulted in a flat baseline and a consequent simplification of the Mueller matrix calculation for our optical system. Based on the Mueller matrix calculation, we have successfully measured real VUV-CD and LD spectra of leucine films for wavelengths down to 160 nm with absolute optical constants. The obtained spectra show good consistency with spectra measured by conventional methods. Copyright 2006 Wiley-Liss, Inc.

  10. Use of molecular variation in the NCBI dbSNP database.

    Science.gov (United States)

    Sherry, S T; Ward, M; Sirotkin, K

    2000-01-01

    While high quality information regarding variation in genes is currently available in locus-specific or specialized mutation databases, the need remains for a general catalog of genome variation to address the large-scale sampling designs required by association studies, gene mapping, and evolutionary biology. In response to this need, the National Center for Biotechnology Information (NCBI) has established the dbSNP database http://ncbi. nlm.nih.gov/SNP/ to serve as a generalized, central variation database. Submissions to dbSNP will be integrated with other sources of information at NCBI such as GenBank, PubMed, LocusLink, and the Human Genome Project data, and the complete contents of dbSNP are available to the public via anonymous FTP. Hum Mutat 15:68-75, 2000. Published 2000 Wiley-Liss, Inc.

  11. The new biological anthropology: bringing Washburn's new physical anthropology into 2010 and beyond--the 2008 AAPA luncheon lecture.

    Science.gov (United States)

    Fuentes, Agustin

    2010-01-01

    Nearly 60 years ago, Sherwood Washburn issued a call for a "New Physical Anthropology," a transition from measurement and classification toward a focus on the processes and mechanisms of evolutionary change. He advocated multidisciplinary and interdisciplinary approaches to the understanding of human behavior, biology, and history. Many interpret this as a call for a practice that is both biological and anthropological. Is this what we do? Are we biological anthropologists yet? In this essay, I explore what we, Physical Anthropologists, as a discipline are doing in the context of a New Physical Anthropology, where we might be headed, and why this discussion is crucial to our relevance. Copyright © 2010 Wiley-Liss, Inc.

  12. Induction of primary root curvature in radish seedlings in a static magnetic field.

    Science.gov (United States)

    Yano, A; Hidaka, E; Fujiwara, K; Iimoto, M

    2001-04-01

    Primary roots of radish (Raphanus sativus L.) seedlings were exposed to an inhomogeneous static magnetic field generated by a permanent magnet, during continuous rotation on a 0.06 rpm clinostat, thereby reducing the unilateral influence of gravity. The roots responded tropically to the static magnetic field with the tropism appearing to be negative. These roots responded significantly (P magnet. The significant tropic response was found for a magnetic flux density of 13-68 mT, for a field gradient of 1.8-14.7 T/m, and for the product of magnetic field and field gradient of 0.023-1.0 T(2)/m. A small, but insignificant, response of the roots to the north pole has also been found. Copyright 2001 Wiley-Liss, Inc.

  13. Introductory comments on special section-genomic microduplications: When adding may equal subtracting.

    Science.gov (United States)

    Bacino, Carlos A; Cheung, Sau-Wai

    2010-05-01

    The clinical implementation of array-based comparative genomic hybridization (aCGH) has allowed detection of copy number variations (CNVs) from megabases in size to those involving only a single exon. One major challenge that followed the clinical implementation of array CGH technology has been the interpretation of CNVs whose clinical significance can be elusive. The copy number gains resulting from genomic rearrangements are often more difficult to interpret than the copy number losses. Some of the CNV gains can be pathogenic, while others can be unrelated to disease since CNVs are often polymorphic in the normal population. The challenge faced by clinicians is how to differentiate between the disease causing CNVs and the nonpathogenic polymorphisms. Therefore, it is critical to systematically collect phenotypic information associated with CNVs and deposit it in searchable and publicly accessible databases. (c) 2010 Wiley-Liss, Inc.

  14. Testosterone and romance: the association of testosterone with relationship commitment and satisfaction in heterosexual men and women.

    Science.gov (United States)

    Hooper, Ann E Caldwell; Gangestad, Steven W; Thompson, Melissa Emery; Bryan, Angela D

    2011-01-01

    The current study extends previous research on testosterone (T) and mating effort by examining whether relationship commitment and satisfaction explain variance in T beyond relationship status alone. Salivary testosterone and self-reported assessments of relationship commitment and satisfaction were assessed among 90 heterosexual men and women (age M = 23.57) in a cross-sectional community sample. Relationship commitment was significantly related to T among men (P 0.05). Controlling for relationship commitment, satisfaction did not predict T levels in men or women (P's > 0.18). The association of increasing relationship commitment with reduced T levels in men confirms and extends prior research linking T with mating effort. Together with previous research, this study suggests that T does not vary with relationship commitment or quality in monogamous, heterosexual women. Copyright © 2011 Wiley-Liss, Inc.

  15. Hormone and pharmaceutical regulation of ASP production in 3T3-L1 adipocytes.

    Science.gov (United States)

    Gao, Ying; Gauvreau, Danny; Cianflone, Katherine

    2010-04-01

    Several studies have demonstrated increases in acylation stimulating protein (ASP), and precursor protein C3 in obesity, diabetes and dyslipidemia, however the nature of the regulation is unknown. To evaluate chronic hormonal and pharmaceutical mediated changes in ASP and potential mechanisms, 3T3-L1 adipocytes were treated with physiological concentrations of relevant hormones and drugs currently used in treatment of metabolic diseases for 48 h. Medium ASP production and C3 secretion were evaluated in relation to changes in adipocyte lipid metabolism (cellular triglyceride (TG) mass, non-esterified fatty acid (NEFA) release and real-time FA uptake). Chylomicrons increased ASP production (up to 411 +/- 133% P ASP production (-53 to -85%, P ASP (-54% to -100%, P ASP were also associated with decreased TG mass (maximal -60%, P ASP profiles in subjects, and suggest that ASP may be regulated through precursor C3 availability, convertase activity and differentiation status. Copyright 2010 Wiley-Liss, Inc.

  16. Structural repertoire of immunoglobulin λ light chains

    KAUST Repository

    Chailyan, Anna

    2011-03-01

    The immunoglobulin λ isotype is present in nearly all vertebrates and plays an important role in the human immune system. Despite its importance, few systematic studies have been performed to analyze the structural conformation of its variable regions, contrary to what is the case for κ and heavy chains. We show here that an analysis of the structures of λ chains allows the definition of a discrete set of recurring conformations (canonical structures) of their hypervariable loops and, most importantly, the identification of sequence constraints that can be used to predict their structure. We also show that the structural repertoire of λ chains is different and more varied than that of the κ chains, consistently with the current view of the involvement of the two major light-chain families in complementary strategies of the immune system to ensure a fine tuning between diversity and stability in antigen recognition. © 2011 Wiley-Liss, Inc.

  17. Taste bud development and patterning in sighted and blind morphs of Astyanax mexicanus.

    Science.gov (United States)

    Varatharasan, Nirupa; Croll, Roger P; Franz-Odendaal, Tamara

    2009-12-01

    In the blind cave-dwelling morph of A. mexicanus, the eye degenerates while other sensory systems, such as gustation, are expanded compared to their sighted (surface-dwelling) ancestor. This study compares the development of taste buds along the jaws of each morph. To determine whether cavefish have an altered onset or rate of taste bud development, we fluorescently labeled basal and receptor cells within taste buds over a developmental series. Our results show that taste bud number increases during development in both morphs. The rate of development is, however, accelerated in cavefish; a small difference in taste bud number exists at 5 dpf reaching threefold by 22 dpf. The expansion of taste buds in cavefish is, therefore, detectable after the onset of eye degeneration. This study provides important insights into the timing of taste bud expansion in cavefish as well as enhances our understanding of taste bud development in teleosts in general. (c) 2009 Wiley-Liss, Inc.

  18. Expression of lactate dehydrogenases A and B during chicken spermatogenesis: characterization of testis specific transcripts.

    Science.gov (United States)

    Arias, W M; Mezquita, C; Mezquita, J

    2000-07-19

    The substrates required for glycolysis change markedly at successive stages of spermatogenesis suggesting a considerable plasticity in the expression of glycolytic enzymes. Lactate dehydrogenase (LDH) isoenzymes, LDH-A and LDH-B, are expressed in premeiotic, meiotic cells, and early spermatids, both in avian and mammalian spermatogenesis. Highly polyadenylated forms, particularly of LDH-A, were detected in chicken testis. While mammals and columbid birds express the testis specific LDH-C gene in meiotic and postmeiotic cells, several LDH-B testis specific transcripts were detected in the corresponding cells during chicken spermatogenesis. These testis specific transcripts and the mRNA of mammalian LDH-C show several properties in common, such as temporal correlation of expression, mRNA stability, and repression of premature translation. These observations suggest that the testis specific transcripts could perform during chicken spermatogenesis the functions of the LDH-C mRNA in mammalian testis. Copyright 2000 Wiley-Liss, Inc.

  19. The search for a deterministic origin for the presence of nonracemic amino-acids in meteorites: a computational approach.

    Science.gov (United States)

    Vandenbussche, Sophie; Reisse, Jacques; Bartik, Kristin; Lievin, Jacques

    2011-05-01

    Amino-acid enantiomeric excesses (ee's) have been detected in different types of carbonaceous chondrites, all in favor of the L enantiomer. In this article, we discuss possible deterministic causes to the presence of these amino-acid ee's in meteorites and evaluate in particular enantioselective photolysis by circularly polarized light (CPL). The electronic circular dichroism spectra of a set of amino- and hydroxy-acids, all detected in chondritic matter but some with ee's and others without ee's, were calculated and compared. The spectra were calculated for the most stable conformation(s) of the considered molecules using quantum mechanical methods (density functional theory). Our results suggest that CPL photolysis in the gas phase was perhaps not at the origin of the presence of ee's in meteorites and that the search for another, but still unknown, deterministic cause must be seriously undertaken. Copyright © 2011 Wiley-Liss, Inc.

  20. Automatic ultrasonic inspection system for wear determination in calandria tubes of Embalse Nuclear Power Plant

    Science.gov (United States)

    Katchadjian, Pablo; Desimone, Carlos; Garcia, Alejandro; Antonaccio, Carlos; Schroeter, Fernando; Molina, Héctor

    2015-03-01

    Embalse Nuclear Power Plant (CNE) (CANDU design) is reaching its end of life and due to elapsed operating time the problem of deformation by accelerated creep occurs in the pressure tubes (PT), leading to a possible contact between calandria tubes (CT), concentric to the PT, and some Liquid Injection Shutdown System (LISS) nozzles that pass underneath them. With determination of CT wear, after the predicted contact occurs, the wear rate of the TC could be determined and thus take less conservative measures over the remaining life of the component. This paper presents the development of an ultrasonic technique for measuring wear in CT, with nominal thickness of 1.34 mm. Because the only access is through the interior of PT, to perform this measurement it is necessary to pass through three different interfaces.

  1. Functional connectivity mapping using the ferromagnetic Potts spin model.

    Science.gov (United States)

    Stanberry, Larissa; Murua, Alejandro; Cordes, Dietmar

    2008-04-01

    An unsupervised stochastic clustering method based on the ferromagnetic Potts spin model is introduced as a powerful tool to determine functionally connected regions. The method provides an intuitively simple approach to clustering and makes no assumptions of the number of clusters in the data or their underlying distribution. The performance of the method and its dependence on the intrinsic parameters (size of the neighborhood, form of the interaction term, etc.) is investigated on the simulated data and real fMRI data acquired during a conventional periodic finger tapping task. The merits of incorporating Euclidean information into the connectivity analysis are discussed. The ability of the Potts model clustering to uncover the hidden structure in the complex data is demonstrated through its application to the resting-state data to determine functional connectivity networks of the anterior and posterior cingulate cortices for the group of nine healthy male subjects. (c) 2007 Wiley-Liss, Inc.

  2. Biological and behavioral determinants of fertility in Tierra del Fuego.

    Science.gov (United States)

    Pascual, J; García-Moro, C E; Hernández, M

    2005-05-01

    The reproductive history of 182 women in postreproductive life or near menopause from the Chilean part of Tierra del Fuego was traced back by means of familial interviews. These postmenopausal women represent the population since almost the beginning of the settlement, and their reproductive years were spent on the island. Path analysis was applied to analyze fertility determinants of these women and to propose a complex model of interconnections among factors. The reproductive history of these women is characterized by a long fertile span, a short childbearing period, and low fertility. Age at menarche is relatively late, and the age of the women at first birth is mainly determined by their late age at marriage. The use of contraception is related to both spacing and stopping behaviors. The late age of women at marriage, the rhythm of conception, and practices of contraception are proposed as the main determinants of fertility in Tierra del Fuego. Copyright 2004 Wiley-Liss, Inc.

  3. Description of the immatures of workers of the ant Linepithema micans Forel (Hymenoptera: Formicidae).

    Science.gov (United States)

    Nondillo, Aline; Solis, Daniel Russ; Fox, Eduardo Gonçalves Paterson; Rossi, Mônica Lanzoni; Botton, Marcos; Bueno, Odair Correa

    2011-04-01

    Linepithema micans Forel is a poorly studied species that is now considered a pest in vineyards in South Brazil. Larval characters have been used in a few phylogenetic studies, and their importance greatly depends in the amount of available information on different species. This study presents a complete panorama on the external morphology of the immatures of L. micans based on observations by light and scanning electron microscopy. The number of larval instars was estimated as three based on the frequency distribution of head widths of 965 larvae. Larvae of L. micans were similar to other Linepithema Mayr in the general format of body and mandibles, presenting a dorsal abdominal protuberance, nine pairs of spiracle, and unbranched hairs. On the other hand, L. micans was unique for having shorter hairs, predominantly denticulate, intraspecific variation in the number of antennal sensilla and in the types of sensilla on the labial palps were reported. Copyright © 2010 Wiley-Liss, Inc.

  4. A TCTN2 mutation defines a novel Meckel Gruber syndrome locus.

    Science.gov (United States)

    Shaheen, Ranad; Faqeih, Eissa; Seidahmed, Mohammed Z; Sunker, Asma; Alali, Faten Ezzat; AlQahtani, Khadijah; Alkuraya, Fowzan S

    2011-06-01

    Meckel Gruber syndrome (MKS) is an autosomal recessive multisystem disorder that represents a severe form of ciliopathy in humans and is characterized by significant genetic heterogeneity. In this article, we describe the identification of a novel MKS locus MKS8 that we map to TCTN2, in a multiplex consanguineous family. TCTN2 is a paralog of the recently identified Tectonic 1, which has been shown to modulate sonic hedgehog signaling. Expression analysis at different developmental stages of the murine ortholog revealed a spatial and temporal pattern consistent with the MKS phenotype observed in our patient. The exclusion of this and the other seven MKS genes in our collection of consanguineous Arab MKS families confirms the existence of two additional MKS loci. © 2011 Wiley-Liss, Inc.

  5. Effects of weak 16 3/2 Hz magnetic fields on growth parameters of young sunflower and wheat seedlings.

    Science.gov (United States)

    Fischer, G; Tausz, M; Köck, M; Grill, Dieter

    2004-12-01

    Previous studies on effects of magnetic fields on plants focussed on the power frequencies (50-60 Hz), but in Austria and Germany electric railways are powered by a frequency of 16 2/3) Hz. In the present study, sunflower and wheat seedlings were exposed to 16 2/3 Hz sinusoidal 20 muT (rms) vertical magnetic fields. Seeds were germinated in a germination roll and grown for 12 days under continued exposure. Seven series with sunflower and six series with wheat were done over 2 years. Sunflower seedlings exposed to experimental magnetic field showed small, but significant increases in total fresh weights, shoot fresh weights, and root fresh weights, whereas dry weights and germination rates remained unaffected. Experimentally treated wheat exhibited marginally (but significantly) higher root fresh and dry weights, total fresh weights, and higher germination rates. 2004 Wiley-Liss, Inc.

  6. New variant of familial cerebellar ataxia with hypergonadotropic hypogonadism and sensorineural deafness.

    Science.gov (United States)

    Amor, D J; Delatycki, M B; Gardner, R J; Storey, E

    2001-02-15

    Cerebellar ataxia and hypergonadotropic hypogonadism comprise a rare and presumably heterogeneous association. Inheritance in most cases appears to be autosomal recessive, and associated features include deafness, intellectual impairment, and neuropathy. Typically, onset of ataxia is in the first decade and hypogonadism results in primary amenorrhoea in females. We describe two sisters with a previously undescribed pattern of adult onset progressive cerebellar ataxia and secondary amenorrhoea due to hypergonadotropic hypogonadism. Sensorineural deafness with vestibular hypofunction and peripheral sensory impairment were also present, and intellect was normal. Onset of neurological symptoms was in the third decade, with secondary amenorrhoea occurring at the ages of 16 and 32 years, respectively. The association of ataxia and hypergonadotropic hypergonadism has been classified both as a variant of Holmes type ataxia and as a variant of Perrault syndrome, but we suggest the use of a separate category of ataxia with hypergonadotropic hypogonadism. Copyright Wiley-Liss. Inc.

  7. Reduction of the Earth's magnetic field inhibits growth rates of model cancer cell lines.

    Science.gov (United States)

    Martino, Carlos F; Portelli, Lucas; McCabe, Kevin; Hernandez, Mark; Barnes, Frank

    2010-12-01

    Small alterations in static magnetic fields have been shown to affect certain chemical reaction rates ex vivo. In this manuscript, we present data demonstrating that similar small changes in static magnetic fields between individual cell culture incubators results in significantly altered cell cycle rates for multiple cancer-derived cell lines. This change as assessed by cell number is not a result of apoptosis, necrosis, or cell cycle alterations. While the underlying mechanism is unclear, the implications for all cell culture experiments are clear; static magnetic field conditions within incubators must be considered and/or controlled just as one does for temperature, humidity, and carbon dioxide concentration. Copyright © 2010 Wiley-Liss, Inc.

  8. Does occasional cannabis use impact anxiety and depression treatment outcomes?: Results from a randomized effectiveness trial.

    Science.gov (United States)

    Bricker, Jonathan B; Russo, Joan; Stein, Murray B; Sherbourne, Cathy; Craske, Michelle; Schraufnagel, Trevor J; Roy-Byrne, Peter

    2007-01-01

    This study investigated the extent to which occasional cannabis use moderated anxiety and depression outcomes in the Collaborative Care for Anxiety and Panic (CCAP) study, a combined cognitive-behavioral therapy (CBT) and pharmacotherapy randomized effectiveness trial. Participants were 232 adults from six university-based primary care outpatient clinics in three West Coast cities randomized to receive either the CCAP intervention or the usual care condition. Results showed significant (Pcannabis use status (monthly vs. less than monthly) for depressive symptoms, but not for panic disorder or social phobia symptoms (all P>.05). Monthly cannabis users' depressive symptoms improved in the CCAP intervention just as much as those who used cannabis less than monthly, whereas monthly users receiving usual care had significantly more depressive symptoms than those using less than monthly. A combined CBT and medication treatment intervention may be a promising approach for the treatment of depression among occasional cannabis users. (c) 2006 Wiley-Liss, Inc.

  9. LAND USE LAND COVER DYNAMICS OF NILGIRIS DISTRICT, INDIA INFERRED FROM SATELLITE IMAGERIES

    Directory of Open Access Journals (Sweden)

    P. Nalina

    2014-01-01

    Full Text Available Land use Land cover changes are critical components in managing natural resources especially in hilly region as they trigger the erosion of soil and thus making the zone highly vulnerable to landslides. The Nilgiris district of Tamilnadu state in India is the first biosphere in Western Ghats region with rare species of flora and fauna and often suffered by frequent landslides. Therefore in this present study land use land cover dynamics of Nilgiri district has been studied from 1990 to 2010 using Satellite Remote Sensing Technique. The temporal changes of land use and land cover changes of Nilgiris district over the period of 1990 to 2010 were monitored using LISS I and LISS III of IRS 1A and IRS-P6 satellites. Land use dynamics were identified using Maximum likelihood classification under supervised classification technique. From the remote sensing study, it is found that during the study period of 1990 to 2010, area of dense forest increased by 27.17%, forest plantation area decreased by 54.64%. Conversion of forest plantation, Range land and open forest by agriculture and settlement leading to soil erosion and landslides. Tea plantation increased by 33.95% and agricultural area for plantation of vegetables increased rapidly to 217.56% in the mountain steep area. The accuracy of classification has been assessed by forming confusion matrix and evaluating kappa coefficient. The overall accuracy has been obtained as 83.7 and 89.48% for the years 1990 and 2010 respectively. The kappa coefficients were reported as 0.80 and 0.88 respectively for the years 1990 and 2010.

  10. Energy Balance of Rural Ecosystems In India

    Science.gov (United States)

    Chhabra, A.; Madhava Rao, V.; Hermon, R. R.; Garg, A.; Nag, T.; Bhaskara Rao, N.; Sharma, A.; Parihar, J. S.

    2014-11-01

    India is predominantly an agricultural and rural country. Across the country, the villages vary in geographical location, area, human and livestock population, availability of resources, agricultural practices, livelihood patterns etc. This study presents an estimation of net energy balance resulting from primary production vis-a-vis energy consumption through various components in a "Rural Ecosystem". Seven sites located in different agroclimatic regions of India were studied. An end use energy accounting "Rural Energy Balance Model" is developed for input-output analysis of various energy flows of production, consumption, import and export through various components of crop, trees outside forest plantations, livestock, rural households, industry or trade within the village system boundary. An integrated approach using field, ancillary, GIS and high resolution IRS-P6 Resourcesat-2 LISS IV data is adopted for generation of various model inputs. The primary and secondary field data collection of various energy uses at household and village level were carried out using structured schedules and questionnaires. High resolution multi-temporal Resourcesat-2 LISS IV data (2013-14) was used for generating landuse/landcover maps and estimation of above-ground Trees Outside Forests phytomass. The model inputs were converted to energy equivalents using country-specific energy conversion factors. A comprehensive geotagged database of sampled households and available resources at each study site was also developed in ArcGIS framework. Across the study sites, the estimated net energy balance ranged from -18.8 Terra Joules (TJ) in a high energy consuming Hodka village, Gujarat to 224.7 TJ in an agriculture, aquaculture and plantation intensive Kollaparru village, Andhra Pradesh. The results indicate that the net energy balance of a Rural Ecosystem is largely driven by primary production through crops and natural vegetation. This study provides a significant insight to policy

  11. Frequencies and Specificities of “Enzyme-Only” Detected Erythrocyte Alloantibodies in Patients Hospitalized in Austria: Is an Enzyme Test Required for Routine Red Blood Cell Antibody Screening?

    Directory of Open Access Journals (Sweden)

    Dietmar Enko

    2014-01-01

    Full Text Available The aim of this study was to determine the frequencies and specificities of “enzyme-only” detected red blood cell (RBC alloantibodies in the routine antibody screening and antibody identification in patients hospitalized in Austria. Routine blood samples of 2420 patients were investigated. The antibody screening was performed with a 3-cell panel in the low-ionic strength saline- (LISS- indirect antiglobulin test (IAT and with an enzyme-pretreated (papain 3-cell panel fully automated on the ORTHO AutoVue Innova System. The antibody identification was carried out manually with an 11-cell panel in the LISS-IAT and with an enzyme-pretreated (papain 11-cell panel. In total 4.05% (n=98 of all patients (n=2420 had a positive RBC antibody screening result. Of them 25.51% (25/98 showed “enzyme-only” detected specific or nonspecific RBC alloantibodies. Rhesus and Lewis system antibodies were found the only specificities of “enzyme-only” RBC alloantibodies: all in all 4.8% (4/98 were detected with anti-E, 3.06% (3/98 with anti-Lea, 3.06% (3/98 with anti-D after anti-D prophylaxis and 1.02% (1/98 with anti-e. In total, 14.29% (14/98 showed a nonspecific RBC alloantibody result with the enzyme test. The results of the present study demonstrate that a high number of unwanted positive reactions with the enzyme technique overshadows the detection of “enzyme-only” RBC alloantibodies. (Trial Registration: K-37-13.

  12. Remote sensing and GIS analysis for demarcation of coastal hazard line along the highly eroding Krishna-Godavari delta front

    Science.gov (United States)

    Kallepalli, Akhil; Kakani, Nageswara Rao; James, David B.

    2016-10-01

    Coastal regions, especially river deltas are highly resourceful and hence densely populated; but these extremely low-lying lands are vulnerable to rising sea levels due to global warming threatening the life and property in these regions. Recent IPCC (2013) predictions of 26-82cm global sea level rise are now considered conservative as subsequent investigations such as by Met Office, UK indicated a vertical rise of about 190cm, which would displace 10% of the world's population living within 10 meters above the sea level. Therefore, predictive models showing the hazard line are necessary for efficient coastal zone management. Remote sensing and GIS technologies form the mainstay of such predictive models on coastal retreat and inundation to future sea-level rise. This study is an attempt to estimate the varying trends along the Krishna-Godavari (K-G) delta region. Detailed maps showing various coastal landforms in the K-G delta region were prepared using the IRS-P6 LISS 3 images. The rate of shoreline shift during a 31-year period along different sectors of the 330km long K-G delta coast was estimated using Landsat-2 and IRS-P6 LISS 3 images between 1977 and 2008. With reference to a selected baseline from along an inland position, End Point Rate (EPR), Shoreline Change Envelope (SCE) and Net Shoreline Movement (NSM) were calculated, using a GIS-based Digital Shoreline Analysis System (DSAS). The results showed that the shoreline migrated landward up to a maximum distance of 3.13km resulting in a net loss of about 42.10km2 area during this 31-year period. Further, considering the nature of landforms and EPR, the future hazard line is predicted for the area, which also indicated a net erosion of about 57.68km2 along the K-G delta coast by 2050 AD.

  13. An approach for land suitability evaluation using geostatistics, remote sensing, and geographic information system in arid and semiarid ecosystems.

    Science.gov (United States)

    Emadi, Mostafa; Baghernejad, Majid; Pakparvar, Mojtaba; Kowsar, Sayyed Ahang

    2010-05-01

    This study was undertaken to incorporate geostatistics, remote sensing, and geographic information system (GIS) technologies to improve the qualitative land suitability assessment in arid and semiarid ecosystems of Arsanjan plain, southern Iran. The primary data were obtained from 85 soil samples collected from tree depths (0-30, 30-60, and 60-90 cm); the secondary information was acquired from the remotely sensed data from the linear imaging self-scanner (LISS-III) receiver of the IRS-P6 satellite. Ordinary kriging and simple kriging with varying local means (SKVLM) methods were used to identify the spatial dependency of soil important parameters. It was observed that using the data collected from the spectral values of band 1 of the LISS-III receiver as the secondary variable applying the SKVLM method resulted in the lowest mean square error for mapping the pH and electrical conductivity (ECe) in the 0-30-cm depth. On the other hand, the ordinary kriging method resulted in a reliable accuracy for the other soil properties with moderate to strong spatial dependency in the study area for interpolation in the unstamped points. The parametric land suitability evaluation method was applied on the density points (150 x 150 m(2)) instead of applying on the limited representative profiles conventionally, which were obtained by the kriging or SKVLM methods. Overlaying the information layers of the data was used with the GIS for preparing the final land suitability evaluation. Therefore, changes in land characteristics could be identified in the same soil uniform mapping units over a very short distance. In general, this new method can easily present the squares and limitation factors of the different land suitability classes with considerable accuracy in arbitrary land indices.

  14. Efficiency assessment of using satellite data for crop area estimation in Ukraine

    Science.gov (United States)

    Gallego, Francisco Javier; Kussul, Nataliia; Skakun, Sergii; Kravchenko, Oleksii; Shelestov, Andrii; Kussul, Olga

    2014-06-01

    The knowledge of the crop area is a key element for the estimation of the total crop production of a country and, therefore, the management of agricultural commodities markets. Satellite data and derived products can be effectively used for stratification purposes and a-posteriori correction of area estimates from ground observations. This paper presents the main results and conclusions of the study conducted in 2010 to explore feasibility and efficiency of crop area estimation in Ukraine assisted by optical satellite remote sensing images. The study was carried out on three oblasts in Ukraine with a total area of 78,500 km2. The efficiency of using images acquired by several satellite sensors (MODIS, Landsat-5/TM, AWiFS, LISS-III, and RapidEye) combined with a field survey on a stratified sample of square segments for crop area estimation in Ukraine is assessed. The main criteria used for efficiency analysis are as follows: (i) relative efficiency that shows how much time the error of area estimates can be reduced with satellite images, and (ii) cost-efficiency that shows how much time the costs of ground surveys for crop area estimation can be reduced with satellite images. These criteria are applied to each satellite image type separately, i.e., no integration of images acquired by different sensors is made, to select the optimal dataset. The study found that only MODIS and Landsat-5/TM reached cost-efficiency thresholds while AWiFS, LISS-III, and RapidEye images, due to its high price, were not cost-efficient for crop area estimation in Ukraine at oblast level.

  15. COMP mutations: domain-dependent relationship between abnormal chondrocyte trafficking and clinical PSACH and MED phenotypes.

    Science.gov (United States)

    Chen, Tung-Ling L; Posey, Karen L; Hecht, Jacqueline T; Vertel, Barbara M

    2008-02-15

    Mutations in cartilage oligomeric matrix protein (COMP) produce clinical phenotypes ranging from the severe end of the spectrum, pseudoachondroplasia (PSACH), which is a dwarfing condition, to a mild condition, multiple epiphyseal dysplasia (MED). Patient chondrocytes have a unique morphology characterized by distended rER cisternae containing lamellar deposits of COMP and other extracellular matrix proteins. It has been difficult to determine why different mutations give rise to variable clinical phenotypes. Using our in vitro cell system, we previously demonstrated that the most common PSACH mutation, D469del, severely impedes trafficking of COMP and type IX collagen in chondrocytic cells, consistent with observations from patient cells. Here, we hypothesize that PSACH and MED mutations variably affect the cellular trafficking behavior of COMP and that the extent of defective trafficking correlates with clinical phenotype. Twelve different recombinant COMP mutations were expressed in rat chondrosarcoma cells and the percent cells with ER-retained COMP was assessed. For mutations in type 3 (T3) repeats, trafficking defects correlated with clinical phenotype; PSACH mutations had more cells retaining mutant COMP, while MED mutations had fewer. In contrast, the cellular trafficking pattern observed for mutations in the C-terminal globular domain (CTD) was not predictive of clinical phenotype. The results demonstrate that different COMP mutations in the T3 repeat domain have variable effects on intracellular transport, which correlate with clinical severity, while CTD mutations do not show such a correlation. These findings suggest that other unidentified factors contribute to the effect of the CTD mutations. J. Cell. Biochem. 103: 778-787, 2008. (c) 2007 Wiley-Liss, Inc. Copyright 2007 Wiley-Liss, Inc.

  16. Hedgehog signaling in the posterior region of the mouse gastrula suggests manifold roles in the fetal-umbilical connection and posterior morphogenesis.

    Science.gov (United States)

    Daane, Jacob M; Downs, Karen M

    2011-09-01

    Although many fetal birth defects, particularly those of the body wall and gut, are associated with abnormalities of the umbilical cord, the developmental relationship between these structures is largely obscure. Recently, genetic analysis of mid-gestation mouse embryos revealed that defects in Hedgehog signaling led to omphalocoele, or failure of the body wall to close at the umbilical ring (Matsumaru et al. [ 2011] PLos One 6:e16260). However, systematic spatiotemporal localization of Hedgehog signaling in the allantois, or umbilical precursor tissue, and the surrounding regions has not been documented. Here, a combination of reagents, including the Ptc1:lacZ and Runx1:lacZ reporter mice, immunohistochemistry for Smoothened (Smo), Sonic Hedgehog (Shh), and Indian hedgehog (Ihh), and detailed PECAM-1/Flk-1/Runx-1 analysis, revealed robust Hedgehog signaling in previously undocumented posterior sites over an extended period of time (∼7.0-9.75 dpc). These included the recently described proximal walls of the allantois (Ventral and Dorsal Cuboidal Mesothelia; VCM and DCM, respectively); the ventral embryonic surface continuous with them; hemogenic arterial endothelia; hematopoietic cells; the hindgut; ventral ectodermal ridge (VER); chorionic ectoderm; and the intraplacental yolk sac (IPY), which appeared to be a site of placental hematopoiesis. This map of Hedgehog signaling in the posterior region of the mouse conceptus will provide a valuable foundation upon which to elucidate the origin of many posterior midline abnormalities, especially those of the umbilical cord and associated fetal defects. Developmental Dynamics 240:2175-2193, 2011. © 2011 Wiley-Liss, Inc. Copyright © 2011 Wiley-Liss, Inc.

  17. Geometric Quality Assessment of Bundle Block Adjusted Mulit- Sensor Satellite Imageries

    Science.gov (United States)

    Ghosh, S.; Bhawani Kumar, P. S.; Radhadevi, P. V.; Srinivas, V.; Saibaba, J.; Varadan, G.

    2014-11-01

    The integration of multi-sensor earth observation data belonging to same area has become one of the most important input for resource mapping and management. Geometric error and fidelity between adjacent scenes affects large-area digital mosaic if the images/ scenes are processed independently. A block triangulation approach "Bundle Block Adjustment (BBA)" system has been developed at ADRIN for combined processing of multi-sensor, multi-resolution satellite imagery to achieve better geometric continuity. In this paper we present the evaluation results of BBA software along with performance assessment and operational use of products thus generated. The application evaluation deals with functional aspects of block-adjustment of satellite imagery consisting of data from multiple sources, i.e. AWiFs, LISS-3, LISS-4 and Cartosat-1 in various combinations as single block. It has provision for automatic generation of GCPs and tie-points using image metafile/ Rational Polynomial Coefficient's (RPC's) and ortho/ merged/ mosaicked products generation. The study is carried out with datasets covering different terrain types (ranging from high mountainous area, moderately undulating terrain, coastal plain, agriculture fields, urban area and water-body) across Indian subcontinent with varying block sizes and spatial reference systems. Geometric accuracy assessment is carried out to figure out error propagation at scene based ortho/ merged products as well as block level. The experimental results confirm that pixel tagging, geometric fidelity and feature continuity across adjacent scenes as well as for multiple sensors reduced to a great extent, due to the high redundancy. The results demonstrate that it is one of the most affective geometric corrections for generating large area digital mosaic over High mountainous terrain using high resolution good swath satellite imagery, like Cartosat-1, with minimum human intervention.

  18. Remote Sensing Based Biophysical Characterization of Tropical Deciduous Forest in Central India

    Science.gov (United States)

    Singh, R. P.; Goroshi, S.; Sharma, N. K.; Bairagi, G. D.; Sharma, R.; Jalil, P.; Jain, A.; Sonakia, A.; Parihar, J. S.

    2011-09-01

    The paper reports the measurements of biophysical parameters using field and satellite data over a tropical deciduous forest Kanha National Park (KNP), central India. Field measurement (GBH, LAI, litter, soil moisture) was carried out over ten quadrates of 0.1ha in KNP for characterization of biophysical parameters with specified measurement protocol and sampling. Satellite based remote sensing analysis (LAI, Phenology, and NPP) was carried out using multi date observations of IRS-LISS-III, IMS-1MX, SPOT-VEGETATION and EOS-MODIS instruments. Rank correlation analysis using field data collected in the selected quadrates at KNP showed Sal (Shorea robusta) is dominant forest species followed by Lendia, Jamun (Syzygium cumini), Saja, Harra and Dhawda etc. Field measurement of Sal showed GBH range from 20 cm to 170 cm. Different forest classes such as Sal; Sal mixed with Jamun, Bamboo (Dendrocalamus strictus) etc, including grasslands/scrubland were classified with overall accuracy of 85.56 percent using March, May and October multi spectral data. Sal has distinct growth characteristics (low vegetation growth/ leaf fall in March instead of May) as compared to other vegetation species. As per the Leaf Area Index (LAI) measurement using hemispherical photographs, Sal showed the highest LAI (6.95 m2/m2) during September and lowest LAI (2.63 m2/m2) during March. Overall good agreement (r= 0.79) was found between the LAI generated from LISS-III and MODIS data product. It was observed from SPOT-VEGETATION analysis that NPP varied from 8.4 tC/ha/year (dry deciduous forest) to 14.25 tC/ha/year (Moist deciduous forest) in KNP.

  19. Fracture-décollement de l’épiphyse médiale de la clavicule: à propos de 6 cas et revue de la littérature

    Science.gov (United States)

    Kassé, Amadou Ndiassé; Limam, Sid’Ahmed Ould Mohamed; Diao, Souleymane; Sané, Jean Claude; Thiam, Babacar; Sy, Mouhamadou Habib

    2016-01-01

    Le but de ce travail est de décrire les caractéristiques épidémiologiques et les différentes entités anatomo-cliniques de la fracture-séparation de l’épiphyse claviculaire médiale mais également de rapporter les résultats morphologiques et fonctionnelsde de la réduction sanglante suivie de l’ostéo-suture au fil non résorbable. Cinq garçons et 1 fille âgés en moyenne de 14 ans ont présenté un traumatisme fermé et isolé de la ceinture scapulaire. L’examen clinique et l’imagerie médicale surtout la TDM ont permis de poser le diagnostic de décollement épiphysaire, de classer le degré d’ossification de l’épiphyse claviculaire médiale en précisant le sens du déplacement, ainsi que la nature du décollement selon Salter-Harris. Une réduction sanglante suivie d’une ostéo-suture au fil non résorbable décimale n°1 a été réalisées chez 3 patients. Un patient a bénéficié d’un embrochage croisé. Les deux plus jeunes ont été traités orthopédiquement. Le déplacement du moignon claviculaire était antérieur chez 3 patients et rétro-sternal chez les 3 autres. Les formes postérieures ont été compliquées d’une odynophagie (n=2) et d’une compression asymptomatique de la veine sous Clavière (n=1). L’une des formes postérieuresétait associée a une fracture ipsilatérale du 1 / 3 médial de la clavicule. La consolidation a été obtenue chez tous les malades avec une mobilité de l’épaule conservée. La fracture-décollement de l’extrémité médiale de la clavicule mime au plan clinico-radiologique la luxation sterno-claviculaire. Elle peut être grave en raison du risque de compression viscérale et vasculaire dans sa forme postérieure. La tomodensitométrie reste irremplaçable pour un diagnostic précis. Notre préférence va à la réduction sanglante suivie d’une ostéo-suture au fil non métallique. PMID:28154711

  20. Etude exploratoire des conceptions de la circulation sanguine aupres d'eleves de l'ordre collegial

    Science.gov (United States)

    Robitaille, Jean-Marc

    prelevent que les nutriments necessaires. Au second niveau les reponses des eleves de la population indiquent une conception de la dynamique cardio-vasculaire axee d'abord sur le coeur, laissant aux vaisseaux un role passif de canaux. Ces reponses indiquent egalement que la dynamique circulatoire est reduite a une sequence d'etapes ponctuelles sans relation les unes avec les autres. Au troisieme niveau les reponses des eleves de la population font etat d'une conception du controle qui privilegie la satisfaction de besoins locaux, sans relation systemique. Nos resultats suggerent que les eleves de notre echantillon affichent une plus grande concordance avec l'expert pour les questions du premier niveau (70%) que pour les niveaux II (54%) et III (50%). Notre analyse des donnees revele que l'accord avec l'expert est eleve lorsque la questions touchent la description des structures et la definition de leurs roles et plus faible lorsque les questions touchent la dynamique et le controle. Il existerait donc un niveau de formulation qui correspond a la description de structures et un autre niveau qui recoupe toute la dynamique de la circulation et son controle. Du point de vue didactique lanalyse des donnees suggere que nous ne retrouvons pas une correspondance entre les niveaux de formulation didactique et les conceptions des eleves. (Abstract shortened by UMI.)

  1. Aphasie : Contraintes vs Gouvernement, le cas des clusters

    Directory of Open Access Journals (Sweden)

    Prince Typhanie

    2012-07-01

    Full Text Available L'objet de ce travail est de comprendre les processus phonologiques qui structurent le langage : pathologique ou non. Notre approche apparie phonologie et aphasiologie. Nous proposons ici une analyse de ces processus phonologiques à travers l'étude des groupes consonantiques dans les structures syllabiques dont ils dépendent. Le cas des clusters apparaît essentiel dans cette problématique. Cet objet n'est que trop peu exploité dans les travaux aphasiologiques alors qu'il s'avère central dans les approches phonologiques par les problèmes représentationnels qu'il pose : relations ou absence de relations entre les consonnes, hétérosyllabicité ou ambisyllabicité. Notre étude prend en compte : - une dimension segmentale : à travers la notion de complexité, - une dimension syllabique : par les relations de gouvernement imposées sur les représentations phonologiques. Nous postulons que ce n'est qu'en considérant l'interrelation de ces dimensions que l'on peut produire une explication des désordres phonologiques observés en pathologie et montrer que des régularités émergent. Dans cet article, nous exposons les traitements proposées à l'aphasie à travers deux cadres phonologiques : la Théorie de l'Optimalité [OT] et la Théorie des Contraintes et des Stratégies de Réparation [TCSR]. Il s'agit d'observer les apports et limites rencontrés par ces modèles. Ensuite, à partir de la Phonologie du Gouvernement, cadre dans lequel nous nous situons, depuis [KLV : 1985] jusqu'à [Scheer : 2010], nous analysons les données et exposons une explication des phénomènes tant au niveau segmental que syllabique. L'étude est basée sur un échantillon de 15 aphasiques (Broca, Wernicke, Conduction de l'unité Neuro- Vasculaire du CHU de Nantes : tous souffrent d'une aphasie consécutive à une lésion cérébrale. Les données ont été récoltées au maximum 72h après le traumatisme à partir d'un protocole expérimental destiné

  2. Evénements indésirables peropératoire: lecture critique du registre du bloc opératoire de l’hôpital militaire Moulay Ismail Meknès

    Science.gov (United States)

    Kechna, Hicham; Ouzzad, Omar; Chkoura, Khalid; Loutid, Jaouad; Hachimi, Moulay Ahmed; Hanafi, Sidi Mohamed

    2016-01-01

    ordre respiratoire (34%) ou cardio vasculaire (31%). On a colligé 5 décès en périopératoire soit une mortalité de 0,28%. La détermination de la cause n’est pas toujours évidente. Le facteur humain serait responsable de 24% des incidents. Conclusion Cette observation illustre les différents événements indésirables survenus depuis la création de ce registre il y a 6 mois. Nous proposons une lecture critique de ce registre dans le seul souci est d’améliorer nos pratiques dans une perspective de renforcer la sécurité anesthésique. PMID:27795775

  3. L'état de santé de la population de la ville de Suceava.

    Directory of Open Access Journals (Sweden)

    Maria-Magdalena LUPCHIAN

    2009-01-01

    éricentraux, où le pourcentage des maladeschroniques est maximal et les malades souffrent surtout de maladies liées à leur âge(hypertension et d’autres maladies cardio-vasculaires, tumeurs malignes, diabète et lesquartiers George Enescu et Iţcani où les maladies chroniques sont liées surtout au style de vieet au niveau moins élevé des revenues (cirrhose, ulcère, anémie, malnutrition. Le quartierdont la population bénéficie du meilleur état de santé est Obcine parce qu’il y a une structurefavorable par âges et un niveau élevé des revenues.

  4. LISS治疗胫骨近端骨折的并发症%Complications of proximal tibia fractures treated with the less invasive stabilization system

    Institute of Scientific and Technical Information of China (English)

    何锦泉; 庞贵根; 胡永成; 陈新; 曾宪铁; 梅小龙; 贾鹏; 孙翔; 王佳

    2008-01-01

    目的 分析使用AO微创内固定系统(less invasive stabilization system,LISS)治疗胫骨近端骨折的并发症.方法 应用LISS治疗45例46侧胫骨近端骨折,男35例,女10例;年龄22~73岁,平均45岁;左28侧,右18侧.高处坠落伤5例,交通事故伤32例,重物砸伤8例.46侧骨折根据AO分类,41A2型4侧、41A3型12侧、41C1型5侧、41C2型19侧、41C3型6侧.9例患者伴有同侧胫骨干骨折,42A3型1例、42B2型4例、42B3型3例、42C3型1例.闭合骨折41侧;开放骨折5侧,根据Gustilo和Anderson分类,Ⅰ型2侧、Ⅱ型3侧.结果 所有病例均获得随访,随访时间为6~25个月,平均11.4个月.所有骨折均愈合,未经额外植骨,无深部感染发生.平均愈合时间为16周,膝关节届曲平均112°,伸直平均-1°.并发症发生率为41.6%,4例(9%)骨折对位不良,1例断端向前成角15°、2例向内成角10°、1例外旋15°畸形.2例(4.3%)骨折术后复位丢失,胫骨平台内翻、塌陷.6侧肢体(13%)出现胫骨近端钢板刺激症状,其中有2侧出现迟发的皮肤软组织全层裂开,行局部胫前肌肌皮瓣转移,伤口愈合.腓浅神经与腓深神经损伤各1例(4.3%),经复查症状改善.9例患者在骨折愈合后行钢板取出,有5例(11%)共5枚螺钉出现"冷焊接现象"(cold-welding)致内固定取出困难.结论 LISS是一种固定胫骨近端骨折有效且可靠的方法.使用过程中需要术者具备精湛的技术和丰富的经验以减少并发症的发生;另外,某些并发症的出现与器械自身因素有关.%Objective To analize the complications in the treatment of the proximal tibial fractures using Less Invasive Stabilization System(LISS).Methods 45 patients with 46 fractures of proximal tibia were treated with the LISS.There were 10 females and 35 males.The mean age of the patients was 45 years (range from 22 to 73 years).The mechanism of injury included fall-down in 5 patients,traffic accident in 32 patients,hit injury in 8 patients

  5. Télémonitorage des grandes fonctions physiologiques chez les primates vigiles Remote monitoring of physiologic functions in monkeys

    Directory of Open Access Journals (Sweden)

    Guy Germain

    2011-02-01

    Full Text Available Les caractéristiques communes à l'étude des primates non-humains sont proches des contraintes que l'on rencontre dans l'application des principes de la télémédecine humaine. Elles découlent de l’éloignement des animaux et de leur dispersion géographique pour les études en milieu naturel, elles découlent aussi du besoin de contrôler au laboratoire les traitements expérimentaux en perturbant le moins possible le comportement social des animaux. Les ondes radio sont un excellent signal de transmission pour le suivi des animaux parce qu'elles peuvent propager des informations rapidement et sur de longues distances dans l'air. Tous les dispositifs télémétriques consistent en un ou plusieurs capteurs couplés à un émetteur encodeur radio et d'un système d'antenne couplé à un récepteur décodeur, analogique ou numérique. Le progrès des télétransmissions résulte par ailleurs de la miniaturisation des dispositifs électroniques d'acquisition et d'émission qui sont de moins en moins gourmands en énergie et acquièrent des durées d'autonomie beaucoup plus grande. De nombreux dispositifs télémétriques très souvent totalement implantables dans le corps de l'animal sont aujourd'hui commercialement disponibles. Ils permettent une surveillance détaillée des paramètres physiologiques des systèmes cardiovasculaire, nerveux, locomoteur, métabolique, respiratoire et reproducteur chez les primates non-humains entièrement libres de leurs mouvements. Ils sont très largement exploités dans les études pharmacologiques et toxicologiques. D'autres dispositifs encore au stade expérimental intègrent également la combinaison de l'enregistrement télémétrique des pressions, biopotentiels musculaires ou nerveux, température, avec des enregistrements audio et vidéo pouvant être eux-mêmes acquis et transmis, partiellement ou en totalité, par télémétrie. Le développement des systèmes futurs sera probablement axé sur les

  6. Idées nouvelles concernant la variable critique de Leloup. Utilisation de cette variable dans le cas des graisses et dans le cas de l'eau New Ldeas About the Leloup Critical Variable. Use of This Variable for Lubricants and Water

    Directory of Open Access Journals (Sweden)

    Bozet J.

    2006-11-01

    Full Text Available Cet article est essentiellement consacré au fonctionnement. d'un palier lisse en conditions limites, les films édifiés à l'interface étant trop minces pour éviter les interactions de surface. L'auteur montre tout d'abord la relation qui existe entre la variable de Leloup, utilisée par un grand nombre de praticiens, et les caractéristiques du film élasto-hydrodynamique qui se développe aux environs du point critique. Il étudie ensuite le comportement de coussinets graphités lubrifiés à l'eau ; il introduit enfin la lubrification à la graisse de paliers lisses classiques. L'analyse des résultats obtenus au laboratoire permet de conclure à la validité de la variable L pour les deux fluides utilisés. A l'issue de son travail, l'auteur indique que la localisation du point critique relevé expérimentalement dans le cas d'une lubrification à la graisse dépend essentiellement des caractéristiques de l'huile de base, le savon ne jouant qu'un rôle très secondaire. This article mainly deals with the boundary lubrication of journal bearings in which the films at the interfaces are too thin to prevent surface friction. The article first describes the relation existing between the Leloup variable used by a great many technicians and the properties of the elastohydrodynamic film created in the area around the critical point. It then examines the behavior of water-lubricated graphite bearings before going on to the lubrication of conventional journal bearings with grease. An analysis of laboratory results leads to the conclusion that the L variable is valid for both types of fluids. The article concludes by situating the critical point determined experimentally on bearings lubricated with grease. The location of this critical point depends mainly on the properfies of the base oil, in which soap plays only a very secondary role.

  7. Linking Spatio-Temporal Land Cover Change to Biodiversity Conservation in the Koshi Tappu Wildlife Reserve, Nepal

    Directory of Open Access Journals (Sweden)

    Sunita Chaudhary

    2013-05-01

    Full Text Available Land cover change has been one of the major drivers of change leading to an alteration of critical habitats for many of the threatened species worldwide. Species with a narrow range and specialized habitats such as wetland ecosystems are at higher risk. The present paper describes spatial and temporal land use and cover change over the period of last 34 years (1976–2010 in the Koshi Tappu Wildlife Reserve (KTWR, Nepal. High spatial resolution Indian Remote-Sensing Satellite (IRS Linear Imaging and Self Scanning Sensor (LISS-4 from 2005 and medium spatial resolution Landsat Multispectral Scanner (MSS from 1976; Thematic Mapper (TM from 1989; Enhanced Thematic Mapper Plus (ETM+ from 1999 and TM from 2010 were used to generate a land use/land cover map and change analysis. Acquired IRS LISS-4 and Landsat image was orthorectified into Universal Transverse Mercator (UTM, Zone 45 based on generated digital terrain model (DTM from a topographic map and Ground Control Point (GCP from the field. After rectifying all the images, eCognition developer software was used for object-based image analysis (OBIA. The change in the land cover and land use types were compared with the potential habitat of twenty globally significant species present in the reserve. The habitat information was collected from the literature and a map was prepared based on ‘presence’ data, habits and habitats used to identify their distribution pattern. The analysis revealed that the KTWR has gone through significant changes in land cover and ecosystems over the last 34 years due to the change in river course and anthropogenic pressure leading to direct change in habitats of the species. Forests have been reduced by 94% from their original state whereas the grassland has increased by 79% from its original state. On the basis of total land cover, forests, river and stream, swamp and marshes decreased by 16%, 14% and 3% respectively over the last 34 years whereas the grassland has

  8. Resourcesat-1: A global multi-observation mission for resources monitoring

    Science.gov (United States)

    Seshadri, K. S. V.; Rao, Mukund; Jayaraman, V.; Thyagarajan, K.; Sridhara Murthi, K. R.

    2005-07-01

    With an array of Indian Remote Sensing Satellites (IRS), a wide variety of national applications have been developed as an inter-agency effort over the past 20 years. Now, the capacity of the programme has been extended into the global arena and IRS is providing operational data services to the global user community. The recently launched IRS satellite, Resourcesat-1, was placed into perfect orbit by India's PSLV and is providing valuable imaging services. Resourcesat-1 is actually like 3 satellites "rolled" into one, imaging a wide field of 710 km area at ˜55 m resolution in multispectral bands from the AWiFS, 23 m resolution in a systematic 142 km swath from four bands of the LISS-3 and the 5.8 m multi-spectral images from the most advanced sensor—LISS-4. Yet another aspect of Resourcesat-1 is it that it marks a "watershed" in terms of a quantum jump in technological capability that India has achieved compared to past missions. The mission has many newer features—the advanced imaging sensors, the more precise attitude and orbit determination systems, the satellite positioning system onboard, the mass storage devices and many other features. This mission has led IRS into a new technological era, and when combined with the technological capability of the forthcoming Cartosat missions, India would have developed technologies that will take us into the new generation of EO satellites for the coming years. This paper provides a detailed description of the Resourcesat-1 mission. From the applications point of view, Resourcesat-1 will open up new avenues for environmental monitoring and resources management—especially for vegetation assessment and disaster management support. The monitoring capability of this mission is also extremely important for a number of applications. The mission has global imaging and servicing capabilities and could be received through the Antrix-Space Imaging network, which markets Resourcesat-1 data worldwide. This paper also describes

  9. Alimentation animale et valeur nutritionnelle induite sur les produits dérivés consommés par l’homme : Les lipides sont-ils principalement concernés ?

    Directory of Open Access Journals (Sweden)

    Bourre Jean-Marie

    2003-09-01

    Full Text Available Dans quelle mesure la nourriture reçue par les animaux induit-elle une modification (amélioration ou au contraire dégradation de la valeur nutritionnelle des aliments qui en sont issus pour la nourriture de l’homme ? La réponse à cette question varie selon la nature des nutriments (vitamines, minéraux, acides gras poly-insaturés indispensables des graisses, acides aminés indispensables des protéines, et aussi de l’espèce considérée. Le problème est de rechercher l’impact réel des formulations des rations utilisées dans les élevages sur la valeur nutritionnelle des produits (viandes, lait et laitages, fromages et œufs, etc., et donc leur influence sur la santé du consommateur, évidemment dans un sens favorable. Les acides gras poly-insaturés oméga-3 (ω3 bénéficient de deux grands axes de valorisation. Le premier réside dans leur importance quantitative et leurs rôles dans le cadre de la mise en place et du maintien de divers organes, le cerveau au premier chef. Le second se trouve dans la prévention de diverses pathologies, les maladies cardio-vasculaires occupant une place prépondérante \\; avec, depuis peu, les maladies neuro-psychiatriques, stress, dépression et démence. Compte tenu des implications en termes de maladies, cardio-cérébro-vasculaires entre autres, le contrôle de la nature des acides gras constitutifs des graisses représente donc un enjeu considérable en ce qui concerne les viandes issues d’animaux terrestres, maritimes et aériens, du lait, des laitages, fromages et des œufs. Car la qualité des graisses données en nourriture animale détermine fondamentalement la valeur nutritionnelle des aliments qui en sont dérivés, pour la consommation humaine. Bien évidemment, il est relativement difficile de modifier la composition en acides gras des phospholipides constitutifs des membranes biologiques intégrées dans la multitude de types cellulaires, dont la spécificité est largement

  10. Preclinical safety evaluations supporting pediatric drug development with biopharmaceuticals: strategy, challenges, current practices.

    Science.gov (United States)

    Morford, LaRonda L; Bowman, Christopher J; Blanset, Diann L; Bøgh, Ingrid B; Chellman, Gary J; Halpern, Wendy G; Weinbauer, Gerhard F; Coogan, Timothy P

    2011-08-01

    Evaluation of pharmaceutical agents in children is now conducted earlier in the drug development process. An important consideration for this pediatric use is how to assess and support its safety. This article is a collaborative effort of industry toxicologists to review strategies, challenges, and current practice regarding preclinical safety evaluations supporting pediatric drug development with biopharmaceuticals. Biopharmaceuticals include a diverse group of molecular, cell-based or gene therapeutics derived from biological sources or complex biotechnological processes. The principles of preclinical support of pediatric drug development for biopharmaceuticals are similar to those for small molecule pharmaceuticals and in general follow the same regulatory guidances outlined by the Food and Drug Administration and European Medicines Agency. However, many biopharmaceuticals are also inherently different, with limited species specificity or immunogenic potential which may impact the approach taken. This article discusses several key areas to aid in the support of pediatric clinical use, study design considerations for juvenile toxicity studies when they are needed, and current practices to support pediatric drug development based on surveys specifically targeting biopharmaceutical development. © 2011 Wiley-Liss, Inc.

  11. PVRL2 is translocated to the TRA@ locus in t(14;19)(q11;q13)-positive peripheral T-cell lymphomas.

    Science.gov (United States)

    Almire, Carole; Bertrand, Philippe; Ruminy, Philippe; Maingonnat, Catherine; Wlodarska, Iwona; Martín-Subero, José I; Siebert, Reiner; Tilly, Hervé; Bastard, Christian

    2007-11-01

    Very few recurrent chromosomal abnormalities have been identified in T-cell non-Hodgkin lymphomas. These involve the TRA@/TRD@ gene at chromosome band 14q11 in up to 15% of cases. We recently reported a novel and recurrent translocation, t(14;19)(q11;q13), in peripheral T-cell lymphoma (PTCL). Fluorescence in situ hybridization analysis performed in three cases suggested an involvement of the TRA@/TRD@ locus at 14q11 and of a region telomeric to BCL3 on 19q13. We now report the molecular cloning of these translocations. Sequence analysis confirmed the involvement of the TRA@/TRD@ and indicated that the breakpoints were located mainly in the TRAJ region. On chromosome 19, our results revealed a new clustering of breakpoints outside the region involved in t(14;19)(q32;q13)-positive B-cell malignancies. Remarkably, all three breaks were located downstream or within the PVRL2 gene, in a small 10.3 kb interval, suggesting a nonrandom location of the breakpoints. For two patients, a high mRNA expression of both PVRL2 and BCL3 was found. In conclusion, we identified PVRL2 as a new recurrent partner gene of the TRA@ locus in PTCL. These results suggest that both BCL3 and PVRL2 may participate in the pathogenesis of these PTCLs, but further studies should be undertaken to investigate the precise role of these genes. Copyright (c) 2007 Wiley-Liss, Inc.

  12. Flow-independent T(2)-prepared inversion recovery black-blood MR imaging.

    Science.gov (United States)

    Liu, Chia-Ying; Bley, Thorsten A; Wieben, Oliver; Brittain, Jean H; Reeder, Scott B

    2010-01-01

    To develop a magnetization preparation method to achieve robust, flow-independent blood suppression for cardiac and vascular magnetic resonance imaging (MRI). T(2)Prep-IR sequence consists of a T(2) preparation followed by a nonselective adiabatic inversion pulse. T(2)Prep separates the initial longitudinal magnetization of arterial wall from lumen blood. After the inversion recovery pulse the imaging acquisition is then delayed for a period that allows the blood signal to approach the zero-crossing point. Compared to the conventional double inversion recovery (DIR) preparation, T(2)Prep-IR prepares all the spins regardless of their velocity and direction. T(2)Prep-IR was incorporated into the fast spin echo and fast gradient echo acquisition sequences and images in various planes were acquired in the carotid arteries, thoracic aorta, and heart of normal volunteers. Blood suppression and image quality were compared qualitatively between two different preparations. For in-plane flow carotid images, persistent flow-related artifacts on the DIR images were removed with T(2)Prep-IR. For cardiac applications, T(2)Prep-IR provided robust blood suppression regardless of the flow direction and velocity, including the cardiac long-axis views and the aorta that are often problematic with DIR. T(2)Prep-IR may overcome the flow dependence of DIR by providing robust flow-independent black-blood images. (c) 2009 Wiley-Liss, Inc.

  13. Occupational exposure to UV light and mortality from multiple sclerosis.

    Science.gov (United States)

    Westberg, M; Feychting, M; Jonsson, F; Nise, G; Gustavsson, P

    2009-05-01

    The etiology of multiple sclerosis (MS) is largely unknown; low exposure to ultraviolet (UV) light has been a suggested risk factor. The aim of this study was to investigate whether occupational exposure to UV light reduces the risk of death from MS. The cohort was based on all individuals in the Swedish census in 1980. All MS-related deaths were identified in the national registry of causes of death. A job-exposure matrix was developed to classify the occupational exposure to UV light. MS was recorded as a cause of the death for 839 individuals. The risk of MS-related death decreased with increasing occupational exposure to UV light. The relative risk adjusted for age, sex, and socioeconomic status was 0.48 (95% CI 0.28-0.80) in the high-exposure group and 0.88 (95% CI 0.73-1.06) in the intermediate-exposure group. Occupational exposure to UV light was associated with a reduced risk of MS. Our findings are corroborated by previous observations that UV light has a preventive role in the development of MS, although the possibility of reversed causality cannot be completely ruled out. Copyright 2009 Wiley-Liss, Inc.

  14. Structure of the adult central complex in Drosophila: organization of distinct neuronal subsets.

    Science.gov (United States)

    Young, J M; Armstrong, J D

    2010-05-01

    The central complex (CX) is a defined set of neuropils located on the midline of the protocerebrum in several arthropods and has been implicated in a number of behaviors. To investigate the function of the CX further it is imperative to know the neuroarchitecture of this structure and to ensure all known neuron types conform to a common nomenclature system. Several types of CX neuron have been identified but it is not known if these exist singly or as components of isomorphic sets. We used an enhancer trap approach to study the adult structure, connectivity, and polarity of CX neurons in Drosophila. We observed several isomorphic sets of small-field neurons including pontine and fb-eb neurons, and also isomorphic sets of large-field neurons including R neurons and F neurons. We found that several types of large-field F neurons existed in isomorphic sets of approximately eight (four per hemisphere) and found evidence for small-field neuron types existing as isomorphic sets of 16. Small-field neurons were observed in clearly organized layers. This study provides a novel insight into CX structure and connectivity and provides a set of characterized enhancer trap lines that will be valuable for future study. (c) 2009 Wiley-Liss, Inc.

  15. Astronomy Festival on the National Mall

    Science.gov (United States)

    Lubowich, D.

    2015-11-01

    The annual Astronomy Festival on the National Mall (AFNM) takes place on 11 acres north of the Washington Monument in June (previous AFNM were April and July). AFNM, sponsored by Hofstra University, features optical and radio telescope viewing of the Sun, Moon, planets, stars, clusters, and nebulae; a live large-screen image, a cell phone imaging mount; exhibits; hands-on activities; videos; large outdoor banners and posters; citizen science activities; hand-outs; bookmarks, and teacher information materials. With no tall buildings almost the entire sky is visible and 10th mag. moons of Saturn and the Ring Nebula (9.75 mag.) were easily visible on clear nights. Representatives from some of the nation's foremost scientific and educational institutions presented exciting demonstrations and activities; and answered questions about careers in science, celestial objects, and the latest astronomical discoveries. Local amateur astronomers set up twenty telescopes on the Mall and long lines of 20-30 people waited to look through the telescopes. Visitors met astronaut Dr. John Grunsfeld (Associate Administrator, NASA) and astronomers Dr. Lisse, Dr. Livengood, Dr. Warren, and Dr. Paul Hertz (Director, Astrophysics Division, NASA). Important historical astronomers spoke to the attendees: Caroline Herschel (Lynn King); Tycho Brahe (Dean Howarth); and Johannes Kepler (Jeff Jones). Free telescopes, donated by Celestron, were raffled off.

  16. [Distribution and air-sea fluxes of methane in the Yellow Sea and the East China Sea in the spring].

    Science.gov (United States)

    Cao, Xing-Peng; Zhang, Gui-Ling; Ma, Xiao; Zhang, Guo-Ling; Liu, Su-Mei

    2013-07-01

    A survey was carried out in the Yellow Sea and the East China Sea from March 17 to April 06 of 2011. Dissolved CH4 in various depths were measured and sea-to-air fluxes were estimated. Methane concentrations in surface and bottom waters ranged between 2.39-29.67 nmol x L(-1) and 2.63-30.63 nmol x L(-1), respectively. Methane concentrations in bottom waters were slightly higher than those in surface waters, suggesting the existence of methane source in bottom waters or sediments. The horizontal distribution of dissolved CH4 showed a decrease from the river mouth to the open sea, and was influenced by the freshwater discharge and the Kuroshio intrusion. Surface methane saturations ranged from 93%-1 038%. Sea to air CH4 fluxes were (2.85 +/- 5.11) micromol x (m2 x d)(-1) (5.18 +/- 9.99) micromol x (m2 x d)(-1) respectively, calculated using the Liss and Merlivat (LM86), the Wanninkhof (W92) relationships and in situ wind speeds, and estimated emission rates of methane from the East China Sea and the Yellow Sea range from 7.05 x 10(-2) - 12.0 x 10(-2) Tg x a(-1) and 1.17 x 10(-2) - 2.20 x 10(-2) Tg x a(-1), respectively. The Yellow Sea and East China Sea are the net sources of atmospheric methane in the spring.

  17. Microarray profiling of monocytic differentiation reveals miRNA-mRNA intrinsic correlation.

    Science.gov (United States)

    Wang, Jing; Xiang, Guangxing; Mitchelson, Keith; Zhou, Yuxiang

    2011-09-01

    MiRNAs (microRNAs) are small non-coding RNAs involved in mammalian gene expression of cellular processes including differentiation, apoptosis and cancer development. Both specific miRNAs and mRNAs have been identified during monocytic differentiation, but their interactions have not been fully characterized. Here we report that by genome-wide microarray analysis for U937 monocytic differentiation induced by TPA, a large number of miRNAs and mRNAs were differentially expressed, and by bioinformatics analysis could demonstrate that their functional pathway patterns overlap strongly. While expected negative correlation between the expression levels of miRNAs and their target mRNAs was seen, several positive correlations between miRNAs and host mRNAs were also observed, such as C13orf25/miR17, MCM7/miR93, and MGC14376/miR22. These microarray data were verified by quantitative RT-PCR, and the TPA-induced differentiation of U937 cells was confirmed by flow cytometric analysis. Our study suggests an intrinsic correlation between miRNAs and mRNAs underlying their interactions which would provide new insights for defining the mechanisms occurring during monocytic differentiation. Copyright © 2011 Wiley-Liss, Inc.

  18. Sur les solutions friables de l'\\'equation a+b=c

    CERN Document Server

    Drappeau, Sary

    2012-01-01

    Dans un r\\'ecent article, Lagarias et Soundararajan \\'etudient les solutions friables \\`a l'\\'equation a+b=c. Sous l'hypoth\\`ese de Riemann g\\'en\\'eralis\\'ees aux fonctions L de Dirichlet, ils obtiennent une estimation pour le nombre de solutions pond\\'er\\'ees par un poids lisse et une minoration pour le nombre de solutions non pond\\'er\\'ees. Le but de cet article est de pr\\'esenter des arguments qui permettent d'une part de pr\\'eciser les termes d'erreur et d'\\'etendre les domaines de validit\\'e de ces estimations afin de faire le lien avec un travail de la Bret\\`eche et Granville, d'autre part d'obtenir le comportement asymptotique exact du nombre de solutions non pond\\'er\\'ees. In a recent paper, Lagarias and Soundararajan study the y-smooth solutions to the equation a+b=c. Under the Generalised Riemann Hypothesis, they obtain an estimate for the number of those solutions weighted by a compactly supported smooth function, as well as a lower bound for the number of bounded unweighted solutions. In this pape...

  19. Population-based study on the seroprevalence of hepatitis A, B, and C virus infection in Amsterdam, 2004.

    Science.gov (United States)

    Baaten, G G G; Sonder, G J B; Dukers, N H T M; Coutinho, R A; Van den Hoek, J A R

    2007-12-01

    In order to enhance screening and preventive strategies, this study investigated the seroprevalence of hepatitis A, B, and C in the general adult urban population and in subgroups. In 2004, sera from 1,364 adult residents of Amsterdam were tested for viral markers. Sociodemographic characteristics were collected using a standardized questionnaire. For hepatitis A, 57.0% was immune. Of first-generation immigrants from Turkey and Morocco, 100% was immune. Of all Western persons and second-generation non-Western immigrants, approximately half was still susceptible. For hepatitis B, 9.9% had antibodies to hepatitis B core antigen (anti-HBc) and 0.4% had hepatitis B surface antigen. Anti-HBc seroprevalences were highest among first-generation immigrants from Surinam, Morocco, and Turkey, and correlated with age at the time of immigration, and among men with a sexual preference for men. Seroprevalence among second-generation immigrants was comparable to Western persons. The seroprevalence of hepatitis C virus antibodies was 0.6%. In conclusion, a country with overall low endemicity for viral hepatitis can show higher endemicity in urban regions, indicating the need for differentiated regional studies and prevention strategies. More prevention efforts in cities like Amsterdam are warranted, particularly for hepatitis A and B among second-generation immigrants, for hepatitis B among men with a sexual preference for men, and for hepatitis C. Active case finding strategies are needed for both hepatitis B and C. (c) Wiley-Liss, Inc.

  20. Depression severity evaluation for female patients based on a functional MRI model.

    Science.gov (United States)

    Qing, Lu; Haiteng, Jiang; Haiyan, Liu; Gang, Liu; Gaojun, Teng; Zhijian, Yao

    2010-05-01

    To develop a functional MRI (fMRI) signal based model that can evaluate depression severity in a numeric form; therefore, depressed patients can be identified during the course of illness, independent from symptoms. Data from 20 medication-free depressed patients and 16 healthy subjects were analyzed. The event-related fMRI scanning features under sad facial emotional stimuli were extracted as model inputs. Fuzzy logic and a genetic algorithm were used to provide suitable model outputs for numeric estimations of depression. The correlation value r between the model estimations and the professional Hamilton Depression Rating Scales (HAMD) was 0.7886 with P < 0.00016. A typical tracking history for a particular subject has also promised the possibility for early disease warning, when the clinal symptoms are ambiguous or recessive. A numeric and objective estimation for the course of illness can be provided. The model can be used by psychiatrists to track the recovery process. As a simple extended application, the proposed model can be applied to classify subjects into different patterns: major depression, moderate depression, or healthy. Copyright 2010 Wiley-Liss, Inc.

  1. Facial emotion recognition and alexithymia in adults with somatoform disorders.

    Science.gov (United States)

    Pedrosa Gil, Francisco; Ridout, Nathan; Kessler, Henrik; Neuffer, Michaela; Schoechlin, Claudia; Traue, Harald C; Nickel, Marius

    2009-01-01

    The primary aim of this study was to investigate facial emotion recognition in patients with somatoform disorders (SFD). Also of interest was the extent to which concurrent alexithymia contributed to any changes in emotion recognition accuracy. Twenty patients with SFD and twenty healthy, age, sex and education matched, controls were assessed with the Facially Expressed Emotion Labelling Test of facial emotion recognition and the 26-item Toronto Alexithymia Scale (TAS-26). Patients with SFD exhibited elevated alexithymia symptoms relative to healthy controls. Patients with SFD also recognized significantly fewer emotional expressions than did the healthy controls. However, the group difference in emotion recognition accuracy became nonsignificant once the influence of alexithymia was controlled for statistically. This suggests that the deficit in facial emotion recognition observed in the patients with SFD was most likely a consequence of concurrent alexithymia. Impaired facial emotion recognition observed in the patients with SFD could plausibly have a negative influence on these individuals' social functioning. (c) 2008 Wiley-Liss, Inc.

  2. Bilateral projections from rat MI whisker cortex to the neostriatum, thalamus, and claustrum: forebrain circuits for modulating whisking behavior.

    Science.gov (United States)

    Alloway, Kevin D; Smith, Jared B; Beauchemin, Kyle J; Olson, Michelle L

    2009-08-10

    In rats, whisking behavior is characterized by high-frequency synchronous movements and other stereotyped patterns of bilateral coordination that are rarely seen in the bilateral movements of the limbs. This suggests that the motor systems controlling whisker and limb movements must have qualitative or quantitative differences in their interhemispheric connections. To test this hypothesis, anterograde tracing methods were used to characterize the bilateral distribution of projections from the whisker and forepaw regions in the primary motor (MI) cortex. Unilateral tracer injections in the MI whisker or forepaw regions revealed robust projections to the corresponding MI cortical area in the contralateral hemisphere. Both MI regions project bilaterally to the neostriatum, but the corticostriatal projections from the whisker region are denser and more evenly distributed across both hemispheres than those from the MI forepaw region. The MI whisker region projects bilaterally to several nuclei in the thalamus, whereas the MI forepaw region projects almost exclusively to the ipsilateral thalamus. The MI whisker region sends dense projections to the contralateral claustrum, but those to the ipsilateral claustrum are less numerous. By contrast, the MI forepaw region sends few projections to the claustrum of either hemisphere. Bilateral deposits of different tracers in MI revealed overlapping projections to the neostriatum, thalamus, and claustrum when the whisker regions were injected, but not when the forepaw regions were injected. These results suggest that the bilateral coordination of the whiskers depends, in part, on MI projections to the contralateral neostriatum, thalamus, and claustrum. Copyright 2009 Wiley-Liss, Inc.

  3. Effect of MRI strength and propofol sedation on pediatric core temperature change.

    Science.gov (United States)

    Isaacson, Diane L; Yanosky, Daniel J; Jones, Richard A; Dennehy, Nancy; Spandorfer, Philip; Baxter, Amy L

    2011-04-01

    To determine core body temperature variations in children undergoing MRI exams on 1.5 Tesla (T) and 3T magnetic field strengths and with and without propofol sedation. Temporal artery temperatures were prospectively collected on 400 consecutive patients undergoing 1.5 Tesla (T) or 3.0T MRI scans. A cumulative logistic regression model was created using age, weight, MRI protocol, sedation status, pre-MRI temperature and MRI strength to assess risk of temperature change. For patients with complete pre- and post-MRI temperature data, mean temperatures did not significantly change (-0.0155°C, 95%CI, -0.035, 0.064; n = 385). Temperature changes differed significantly between propofol-sedated and nonsedated patients (-0.26°C ± .44 versus 0.24°C ± 0.42; P 1°C; 12 were on the 1.5T. All 7 patients (1.8%) who increased >1°C were non-sedates. Clinically significant core body temperature change is uncommon in children undergoing MRI with different magnetic field strengths, and with and without propofol sedation. Copyright © 2011 Wiley-Liss, Inc.

  4. TranScreen-N: Method for rapid screening of trans-ungual drug delivery enhancers.

    Science.gov (United States)

    Murthy, S Narasimha; Vaka, Siva Ram Kiran; Sammeta, Srinivasa Murthy; Nair, Anroop B

    2009-11-01

    Topical monotherapy of nail diseases such as onychomycosis and nail psoriasis has been less successful due to poor permeability of the human nail plate to topically administered drugs. Chemical enhancers are utilized to improve the drug delivery across the nail plate. Choosing the most effective chemical enhancers for the given drug and formulation is highly critical in determining the efficacy of topical therapy of nail diseases. Screening the large pool of enhancers using currently followed diffusion cell experiments would be tedious and expensive. The main objective of this study is to develop TranScreen-N, a high throughput method of screening trans-ungual drug permeation enhancers. It is a rapid microwell plate based method which involves two different treatment procedures; the simultaneous exposure treatment and the sequential exposure treatment. In the present study, several chemicals were evaluated by TranScreen-N and by diffusion studies in the Franz diffusion cell (FDC). Good agreement of in vitro drug delivery data with TranScreen-N data provided validity to the screening technique. In TranScreen-N technique, the enhancers can be grouped according to whether they need to be applied before or simultaneously with drugs (or by either procedures) to enhance the drug delivery across the nail plate. TranScreen-N technique can significantly reduce the cost and duration required to screen trans-ungual drug delivery enhancers. (c) 2009 Wiley-Liss, Inc. and the American Pharmacists Association

  5. Effects of organic solvents on the barrier properties of human nail.

    Science.gov (United States)

    Smith, Kelly A; Hao, Jinsong; Li, S Kevin

    2011-10-01

    The effects of organic solvent systems on nail hydration and permeability have not been well studied. The objectives of the present study were to investigate the effects of binary aqueous organic solvent systems of ethanol (EtOH), propylene glycol (PPG), and polyethylene glycol 400 (PEG) on the barrier properties of nail plates. (3) H-water, (14) C-urea, and (14) C-tetraethylammonium ions were the probes in the nail uptake and transport experiments to study the effect(s) of organic solvents on nail hydration and permeability. Gravimetric studies were also performed as a secondary method to study nail hydration and the reversibility of the nail after organic solvent treatments. Both ungual uptake and transport were directly related to the concentration of the organic solvent in the binary systems. Partitioning of the probes into and transport across the nail decreased with an increase in the organic solvent concentration. These changes corresponded to the changes in solution viscosity and the barrier properties of the nail. In general, the effects for PPG and PEG were more pronounced than those for EtOH. Practically, these results suggest that organic solvents in formulations can increase nail barrier resistivity. Copyright © 2011 Wiley-Liss, Inc.

  6. Influence of pH on transungual passive and iontophoretic transport.

    Science.gov (United States)

    Smith, Kelly A; Hao, Jinsong; Li, S Kevin

    2010-04-01

    The present study investigated the effects of pH on nail permeability and the transport of ions such as sodium (Na) and chloride (Cl) ions endogenous to nail and hydronium and hydroxide ions present at low and high pH, which might compete with drug transport across hydrated nail plate during iontophoresis. Nail hydration and passive transport of water across the nail at pH 1-13 were assessed. Subsequently, passive and iontophoretic transport experiments were conducted using (22)Na and (36)Cl ions under various pH conditions. Nail hydration was independent of pH under moderate pH conditions and increased significantly under extreme pH conditions (pH >11). Likewise, nail permeability for water was pH independent at pH 1-10 and an order of magnitude higher at pH 13. The results of passive and iontophoretic transport of Na and Cl ions are consistent with the permselective property of nail. Interestingly, extremely acidic conditions (e.g., pH 1) altered nail permselectivity with the effect lasting several days at the higher pH conditions. Hydronium and hydroxide ion competition in iontophoretic transport was generally negligible at pH 3-11 was significant at the extreme pH conditions studied. 2009 Wiley-Liss, Inc. and the American Pharmacists Association

  7. Myosin heavy chain composition of tiger (Panthera tigris) and cheetah (Acinonyx jubatus) hindlimb muscles.

    Science.gov (United States)

    Hyatt, Jon-Philippe K; Roy, Roland R; Rugg, Stuart; Talmadge, Robert J

    2010-01-01

    Felids have a wide range of locomotor activity patterns and maximal running speeds, including the very fast cheetah (Acinonyx jubatas), the roaming tiger (Panthera tigris), and the relatively sedentary domestic cat (Felis catus). As previous studies have suggested a relationship between the amount and type of activity and the myosin heavy chain (MHC) isoform composition of a muscle, we assessed the MHC isoform composition of selected hindlimb muscles from these three felid species with differing activity regimens. Using gel electrophoresis, western blotting, histochemistry, and immunohistochemistry with MHC isoform-specific antibodies, we compared the MHC composition in the tibialis anterior, medial gastrocnemius (MG), plantaris (Plt), and soleus muscles of the tiger, cheetah, and domestic cat. The soleus muscle was absent in the cheetah. At least one slow (type I) and three fast (types IIa, IIx, and IIb) MHC isoforms were present in the muscles of each felid. The tiger had a high combined percentage of the characteristically slower isoforms (MHCs I and IIa) in the MG (62%) and the Plt (86%), whereas these percentages were relatively low in the MG (44%) and Plt (55%) of the cheetah. In general, the MHC isoform characteristics of the hindlimb muscles matched the daily activity patterns of these felids: the tiger has daily demands for covering long distances, whereas the cheetah has requirements for speed and power. (c) 2009 Wiley-Liss, Inc.

  8. Renal artery stenting with noninvasive duplex ultrasound follow-up: 3-year results from the RENAISSANCE renal stent trial.

    Science.gov (United States)

    Rocha-Singh, Krishna; Jaff, Michael R; Lynne Kelley, E

    2008-11-15

    The multicenter, single-arm RENAISSANCE trial evaluated outcomes in patients with progressive atherosclerotic renal artery stenosis (ARAS) treated with the Express Renal Premounted Stent System (Boston Scientific, Natick, MA). Renal artery stenting may prevent the morbidity and mortality of surgical revascularization and high restenosis rates of percutaneous renal angioplasty (PTRA). Renal artery duplex ultrasonography (DUS) offers an alternative to traditional invasive poststenting angiographic surveillance, though concordance with angiography for in-stent restenosis has yet to be validated independently. RENAISSANCE enrolled 100 patients (117 lesions) with de novo or restenotic ostial atherosclerotic lesions or=4.0 and or=70%. The primary endpoint, 9-month binary restenosis, was compared to an objective performance criterion (OPC) of 40% for published PTRA results. Follow-up was conducted through 3 years. Technical and procedural success was both 99%. Follow-up angiography, triggered clinically or by ultrasonography, revealed 21.3% binary restenosis at 9 months, which was superior to the OPC (P RENAISSANCE demonstrates that renal artery stenting is superior to the prespecified OPC at 9 months, and also shows that DUS can accurately identify in-stent restenosis. (c) 2008 Wiley-Liss, Inc.

  9. Thermodynamics of cosolvent action: phenacetin, salicylic acid and probenecid.

    Science.gov (United States)

    Peña, M A; Escalera, B; Reíllo, A; Sánchez, A B; Bustamante, P

    2009-03-01

    The solubility of phenacetin, salicylic acid, and probenecid in ethanol-water and ethanol-ethyl acetate mixtures at several temperatures (15-40 degrees C) was measured. The solubility profiles are related to medium polarity changes. The apparent thermodynamic magnitudes and enthalpy-entropy relationships are related to the cosolvent action. Salicylic acid and probenecid show a single peak against the solubility parameter delta(1) of both solvent mixtures, at 40% (delta(1) = 21.70 MPa(1/2)) and 30% (delta(1) = 20.91 MPa(1/2)) ethanol in ethyl acetate, respectively. Phenacetin displays two peaks at 60% ethanol in ethyl acetate (23.30 MPa(1/2)) and 90% ethanol in water (delta(1) = 28.64 MPa(1/2)). The apparent enthalpies of solution display a maximum at 30% (phenacetin and salicylic acid) and 40% (probenecid) ethanol in water, respectively. Two different mechanisms, entropy at low ethanol ratios, and enthalpy at high ethanol ratios control the solubility enhancement in the aqueous mixture. In the nonaqueous mixture (ethanol-ethyl acetate) enthalpy is the driving force throughout the whole solvent composition for salicylic acid and phenacetin. For probenecid, the dominant mechanism shifts from entropy to enthalpy as the ethanol in ethyl acetate concentration increases. The enthalpy-entropy compensation plots corroborate the different mechanisms involved in the solubility enhancement by cosolvents. (c) 2008 Wiley-Liss, Inc. and the American Pharmacists Association

  10. Triple-balloon pulmonary valvuloplasty: an advantageous technique for percutaneous repair of pulmonary valve stenosis in the large pediatric and adult patients.

    Science.gov (United States)

    Escalera, Robert B; Chase, Thaddeus J; Owada, Carl Y

    2005-11-01

    This report describes a new valvuloplasty procedure for the treatment of pulmonary valve stenosis (PVS) and large pulmonary valve annulus (PVA) diameters using a triple-balloon valvuloplasty (TBV) technique. We sought to demonstrate the safety and efficacy of this new technique. Percutaneous balloon pulmonary valvuloplasty (BPV) is the preferred treatment for PVS. BPV in older patients with large PVA remains a challenge, even when the double-balloon valvuloplasty technique is performed. The technique was first attempted in a case where a large single balloon was unsuccessful and double-balloon valvuloplasty met with technical difficulties. Three subsequent patients underwent the procedure safely and successfully. An algorithm is presented to determine balloon size for TBV. The median PVA diameter was 23.9 mm. Balloon diameters ranged from 12 to 18 mm. The median peak right ventricular-to-pulmonary artery systolic pressure gradient was 43.5 mm Hg before valvuloplasty and was reduced to 12 mm Hg following intervention. No major complications were encountered. Percutaneous valvuloplasty using TBV can be performed safely and provides excellent clinical results. This technique offers advantages over single-balloon and double-balloon valvuloplasty techniques, especially in treatment of PVS in large pediatric or adult patients. Copyright 2005 Wiley-Liss, Inc.

  11. An investigation of human apolipoproteins B and E polymorphisms in two African populations from Ethiopia and Benin.

    Science.gov (United States)

    Corbo, R.M.; Scacchi, R.; Rickards, O.; Martinez-Labarga, C.; De Stefano, G.F.

    1999-01-01

    Three polymorphisms (XbaI, EcoRI, and Ins/Del) of the apolipoprotein B (APOB) gene and the polymorphism of apolipoprotein E (APOE) were investigated in two population samples of Amhara and Oromo origin from Ethiopia, and in two population samples of Bariba and Berba origin from Benin. No heterogeneity was observed within each major group. The cumulated frequencies of the APOB X+, R+, and D alleles for the Ethiopia and the Benin groups were 0.268 and 0.133, 0.958 and 0.818, 0.206 and 0.223, respectively. Regarding APOE, the cumulated allele frequencies of Ethiopia and Benin were 0.031 and 0.103 for epsilon*2 allele, 0.811 and 0.742 for epsilon*3, and 0.143 and 0.155 for epsilon*4, respectively. APOE typing performed at the protein level only in the Ethiopians revealed a variant allele, epsilon*5, found at the polymorphic level both in the Amhara and in the Oromo (cumulated frequency: 0.015). A tentative explanation for the higher frequencies of epsilon*4 and epsilon*5 alleles was sought in relation to the lifestyle and ethnicity of the two populations. Am. J. Hum. Biol. 11:297-304, 1999. Copyright 1999 Wiley-Liss, Inc.

  12. Cell death in ovarioles causes permanent sterility in Frieseomelitta varia worker bees.

    Science.gov (United States)

    Boleli, I C; Paulino-Simões, Z L; Gentile Bitondi, M M

    1999-12-01

    Frieseomelitta varia worker bees do not lay eggs even when living in queenless colonies, a condition that favors ovary development and oviposition in the majority of highly social bees. The permanent sterility of these worker bees was initially attributed to a failure in ovary morphogenesis and differentiation. Using transmission electron microscopy we found that at the beginning of the pupal phase the ovaries of F. varia workers are formed by four ovarioles, each of them composed of 1) a terminal filament at the apex of the ovarioles, containing juxtaposed and irregularly shaped cells, 2) a germarium with clusters of cystocytes and prefollicular cells showing long cytoplasmic projections that envelop the cystocyte clusters, 3) fusiform interfollicular and basal stalk precursor cells, and 4) globular, irregularly contoured basal cells with large nuclei. However, during the pupal phase an accentuated and progressive process of cell death takes place in the ovarioles. The dying cells are characterized by large membrane bodies, electron-dense apoptotic bodies, vacuoles, vesiculation, secondary lysosomes, enlarged rough endoplasmic reticulum cisternae, swollen mitochondria, pycnotic nuclei, masses of chromatin adjacent to the convoluted nuclear envelope, and nucleoli showing signs of fragmentation. Cell death continues in ovarioles even after the emergence of the workers. Once they become nurse bees, the ovaries have become transformed into a cell mass in which structurally organized ovarioles can no longer be identified. In F. varia workers, ovariole cell death most certainly is part of the program of caste differentiation. Copyright 1999 Wiley-Liss, Inc.

  13. Tail growth tracks the ontogeny of prehensile tail use in capuchin monkeys (Cebus albifrons and C. apella).

    Science.gov (United States)

    Russo, Gabrielle A; Young, Jesse W

    2011-11-01

    Physical anthropologists have devoted considerable attention to the structure and function of the primate prehensile tail. Nevertheless, previous morphological studies have concentrated solely on adults, despite behavioral evidence that among many primate taxa, including capuchin monkeys, infants and juveniles use their prehensile tails during a greater number and greater variety of positional behaviors than do adults. In this study, we track caudal vertebral growth in a mixed longitudinal sample of white-fronted and brown capuchin monkeys (Cebus albifrons and Cebus apella). We hypothesized that young capuchins would have relatively robust caudal vertebrae, affording them greater tail strength for more frequent tail-suspension behaviors. Our results supported this hypothesis. Caudal vertebral bending strength (measured as polar section modulus at midshaft) scaled to body mass with negative allometry, while craniocaudal length scaled to body mass with positive allometry, indicating that infant and juvenile capuchin monkeys are characterized by particularly strong caudal vertebrae for their body size. These findings complement previous results showing that long bone strength similarly scales with negative ontogenetic allometry in capuchin monkeys and add to a growing body of literature documenting the synergy between postcranial growth and the changing locomotor demands of maturing animals. Although expanded morphometric data on tail growth and behavioral data on locomotor development are required, the results of this study suggest that the adult capuchin prehensile-tail phenotype may be attributable, at least in part, to selection on juvenile performance, a possibility that deserves further attention. Copyright © 2011 Wiley-Liss, Inc.

  14. Independence of biomechanical forces and craniofacial pneumatization in Cebus.

    Science.gov (United States)

    Rae, Todd C; Koppe, Thomas

    2008-11-01

    Several different factors have been hypothesized as explanations of variation in primate paranasal sinus size. Biomechanical forces, particularly those associated with mastication, are frequently evoked to account for differences in primate craniofacial pneumatization. To test whether masticatory stresses are responsible for maxillary sinus volume diversity, two platyrrhine species of the genus Cebus (C. apella and C. albifrons) were examined. The former has been identified as a hard object feeder, and many morphological differences between the two species are attributable to differences in the mechanical properties of their respective diets. Sinus volumes were derived from serial coronal CT scans of the crania of adults. Several external cranial measurements were used to scale sinus volume relative to the size of the face. Relative measures of maxillary sinus volume were compared using standard statistical techniques. In all comparisons, the two capuchin species do not differ from one another significantly at P < 0.05. Thus, this "natural experiment" fails to support the interpretation that biomechanical forces acting on the facial skeleton substantially affect the degree of paranasal pneumatization in primates. This result suggests that it is unlikely that the maxillary sinus performs any function in relation to masticatory stress; other factors must be responsible for the variation in sinus volume among primates. Copyright 2008 Wiley-Liss, Inc.

  15. ABO/RH DISTRIBUTION PATTERN AND PREVALENCE OF IRREGULAR ANTIBODIES IN HEALTHY BLOOD DONORS OF UTTARAKHAND

    Directory of Open Access Journals (Sweden)

    Brijesh Thakur

    2016-07-01

    Full Text Available BACKGROUND Blood group plays a vital role in transfusion safety, understanding genetics, inheritance pattern and disease susceptibility. This study is aimed to determine distribution pattern of ABO and Rh blood group, incidence and identification of irregular antibodies among blood donors of Uttarakhand. METHOD ABO/Rh blood grouping was performed by test tube agglutination method (both cell and serum grouping using antisera A, B and Rh from Tulip and Orthodiagnostics. Donors’ plasma were screened for irregular antibodies by indirect antiglobulin technique using Bio-Rad ID-Card “LISS/Coombs” and test cell reagents “ID-DiaCell” via gel centrifugation. RESULTS Out of total 4573 included blood donors, 88.2% were males. The maximum blood donors (77.6% were in 18-25 years of age group. The commonest ABO blood group present was B (36.1% followed by O (29.1%, A (24.8% and AB (10% in blood donors; while in Rhesus system, 95.0% donors were Rh-positive and 5.0% donors were Rh negative. Screening of donors’ plasma did not reveal any detectable irregular antibody. CONCLUSION The study has a significant implication in suggesting the distribution pattern of ABO/Rh blood group typing in the region, but routine irregular antibody screening in healthy blood donors may not be fruitful in this region keeping cost effectiveness and absence of previous sensitization in mind

  16. Meat intake and meat preparation in relation to risk of postmenopausal breast cancer in the NIH-AARP diet and health study.

    Science.gov (United States)

    Kabat, Geoffrey C; Cross, Amanda J; Park, Yikyung; Schatzkin, Arthur; Hollenbeck, Albert R; Rohan, Thomas E; Sinha, Rashmi

    2009-05-15

    A number of studies have reported that intake of red meat or meat cooked at high temperatures is associated with increased risk of breast cancer, but other studies have shown no association. We assessed the association between meat, meat-cooking methods, and meat-mutagen intake and postmenopausal breast cancer in the NIH-AARP Diet and Health Study cohort of 120,755 postmenopausal women who completed a food frequency questionnaire at baseline (1995-1996) as well as a detailed meat-cooking module within 6 months following baseline. During 8 years of follow-up, 3,818 cases of invasive breast cancer were identified in this cohort. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). After adjusting for covariates, intake of total meat, red meat, meat cooked at high temperatures, and meat mutagens showed no association with breast cancer risk. This large prospective study with detailed information on meat preparation methods provides no support for a role of meat mutagens in the development of postmenopausal breast cancer. (c) 2008 Wiley-Liss, Inc.

  17. Evidence for neural accommodation to a writing system following learning.

    Science.gov (United States)

    Liu, Ying; Dunlap, Susan; Fiez, Julie; Perfetti, Charles

    2007-11-01

    Native English speakers with no knowledge of Chinese were trained on 60 Chinese characters according to one of three mapping conditions: orthography to pronunciation and meaning (P + M), orthography to pronunciation (P), and orthography to meaning (M). Following the training, fMRI scans taken during passive viewing of Chinese characters showed activation in brain regions that partially overlap the regions found in studies of skilled Chinese readers, but typically not found in alphabetic readers. Areas include bilateral middle frontal (BA 9), right occipital (BA 18/19), and fusiform (BA 37) regions. The activation pattern of Chinese characters was similar across the three groups. However, peak location was different in the left middle frontal region between groups. Direct contrasts between the groups also revealed stronger activation of left middle frontal in the P + M group. The results suggest that learners acquired skill in reading Chinese characters using a brain network similar to that used by Chinese native speakers. The results are consistent with the system accommodation hypothesis: The brain's reading network accommodates to features of an acquired writing system. Copyright 2007 Wiley-Liss, Inc.

  18. Apigenin inhibits oxidative stress-induced macromolecular damage in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinogenesis in Wistar albino rats.

    Science.gov (United States)

    Jeyabal, Prince Vijeya Singh; Syed, Mumtaz Banu; Venkataraman, Magesh; Sambandham, Jamuna Kumari; Sakthisekaran, Dhanapal

    2005-09-01

    Apigenin (4',5,7-trihydroxyflavone), a flavone subclass of flavonoid widely distributed in many herbs, fruits, and vegetables is a substantial component of the human diet and has been shown to possess a variety of biological activities including tumor growth inhibition and chemoprevention. Recent studies in several biological systems have shown that apigenin induces tumor growth inhibition, cell cycle arrest, and apoptosis. Free radical-induced degradation of polyunsaturated fatty acid results in electrophilic products and causes severe oxidative stress. Oxidative stress induced by free radicals, nonoxidizing species, electrophiles, and associated DNA damages have been frequently coupled with carcinogenesis. In the present study, the protective role of apigenin was examined against the oxidative stress caused by N-nitrosodiethylamine (NDEA) and phenobarbital (PB) in Wistar albino rats. Oxidative stress was measured in terms of lipid peroxidation (LPO) and protein carbonyl formation. Oxidative stress-induced DNA damage was measured by single cell gel electrophoresis (comet assay). Apigenin exhibited its antioxidant defense against NDEA-induced oxidative stress. We have observed minimal levels of LPO and DNA damage in apigenin-treated hepatoma bearing animals. Based on the results, we suggest that apigenin may be developed as a promising chemotherapeutic agent against the development of chemical carcinogenesis. (c) 2005 Wiley-Liss, Inc.

  19. Vagal neural crest cell migratory behavior: a transition between the cranial and trunk crest.

    Science.gov (United States)

    Kuo, Bryan R; Erickson, Carol A

    2011-09-01

    Migration and differentiation of cranial neural crest cells are largely controlled by environmental cues, whereas pathfinding at the trunk level is dictated by cell-autonomous molecular changes owing to early specification of the premigratory crest. Here, we investigated the migration and patterning of vagal neural crest cells. We show that (1) vagal neural crest cells exhibit some developmental bias, and (2) they take separate pathways to the heart and to the gut. Together these observations suggest that prior specification dictates initial pathway choice. However, when we challenged the vagal neural crest cells with different migratory environments, we observed that the behavior of the anterior vagal neural crest cells (somite-level 1-3) exhibit considerable migratory plasticity, whereas the posterior vagal neural crest cells (somite-level 5-7) are more restricted in their behavior. We conclude that the vagal neural crest is a transitional population that has evolved between the head and the trunk. Copyright © 2011 Wiley-Liss, Inc.

  20. Protein electron transfer (mechanism and reproductive toxicity): iminium, hydrogen bonding, homoconjugation, amino acid side chains (redox and charged), and cell signaling.

    Science.gov (United States)

    Kovacic, Peter

    2007-03-01

    This contribution presents novel biochemical perspectives of protein electron transfer (ET) with focus on the iminium nature of the peptide link, along with relationships to reproductive toxicity. The favorable influence of hydrogen bonding on protein ET has been widely documented. Hydrogen bonding of the zwitterionic peptide enhances iminium character. A wide array of such bonding agents is available in vivo, with many reports on the peptide link itself. ET proceeds along the backbone, due in part, to homoconjugation. Redox amino acids (AAs), mainly tyrosine (Tyr), tryptophan (Typ), histidine (His), cysteine (Cys), disulfide, and methionine (Met), are involved in the competing processes for radical formation: direct hydrogen atom abstraction versus electron and proton loss. It appears that the radical or radical cation generated during the redox process is capable of interacting with n-electrons of the backbone. Beneficial effects of cationic AAs impact the conduction process. A relationship apparently exists involving cell signaling, protein conduction, and radicals or electrons. In addition, the link between protein ET and reproductive toxicity is examined. A key element is the role of reactive oxygen species (ROS) generated by protein ET. There is extensive evidence for involvement of ROS in generation of birth defects. The radical species arise in protein mainly by ET transformations by enzymes, as illustrated in the case of alcoholism. (c) 2007 Wiley-Liss, Inc.

  1. Faster dynamic imaging of speech with field inhomogeneity corrected spiral fast low angle shot (FLASH) at 3 T.

    Science.gov (United States)

    Sutton, Bradley P; Conway, Charles A; Bae, Youkyung; Seethamraju, Ravi; Kuehn, David P

    2010-11-01

    To evaluate the impact of magnetic field inhomogeneity correction on achievable imaging speeds for magnetic resonance imaging (MRI) of articulating oropharyngeal structures during speech and to determine if sufficient acquisition speed is available for visualizing speech structures with real-time MRI. We designed a spiral fast low angle shot (FLASH) sequence that combines several acquisition techniques with an advanced image reconstruction approach that includes magnetic field inhomogeneity correction. A simulation study was performed to examine the interaction between imaging speed, image quality, number of spiral shots, and field inhomogeneity correction. Six volunteer subjects were scanned to demonstrate adequate visualization of articulating structures during simple speech samples. The simulation study confirmed that magnetic field inhomogeneity correction improves the available tradeoff between image quality and speed. Our optimized sequence co-acquires magnetic field maps for image correction and achieves a dynamic imaging rate of 21.4 frames per second, significantly faster than previous studies. Improved visualization of anatomical structures, such as the soft palate, was also seen from the field-corrected reconstructions in data acquired on volunteer subjects producing simple speech samples. Adequate temporal resolution of articulating oropharyngeal structures during speech can be obtained by combining outer volume suppression, multishot spiral imaging, and magnetic field corrected image reconstruction. Correcting for the large, dynamic magnetic field variation in the oropharyngeal cavity improves image quality and allows for higher temporal resolution. © 2010 Wiley-Liss, Inc.

  2. Site characterization studies along coastal Andhra Pradesh—India using multichannel analysis of surface waves

    Science.gov (United States)

    Trupti, S.; Srinivas, K. N. S. S. S.; Pavan Kishore, P.; Seshunarayana, T.

    2012-04-01

    Multichannel analysis of surface waves (MASW) technique was employed for site characterization studies at the identified lineament locations along coastal regions of Andhra Pradesh covering ~ 600 km to measure the shear wave velocity. The shear (S)-wave velocity of near surface materials (such as soil, rocks and pavement) and its effect on seismic wave propagation are of fundamental interest in many groundwater, engineering and environmental studies. Geologically, the study area comprises of Precambrian basement over which younger rocks commencing with Jurassic, Cretaceous, Tertiary and Quaternary have given rise to varying sequences in different parts. The study has been conducted along the lineaments and these were selected based on the analysis of IRS-1D LISS-IV satellite images and the field geological investigation. The average shear wave velocity, stiffness and the liquefaction potential were evaluated by using the obtained shear wave velocities. Soils are classified into four categories as soft soils, stiff soils, dense soils/soft rock and hard rock based on the obtained shear wave velocities. The factor of safety (FS) against liquefaction is determined and it is found that the sites with low shear wave velocity have FS canal alignments, and cross-drainage structures.

  3. Dielectric relaxation and crystallization of ultraviscous melt and glassy states of aspirin, ibuprofen, progesterone, and quinidine.

    Science.gov (United States)

    Johari, G P; Kim, S; Shanker, Ravi M

    2007-05-01

    Molecular relaxation in ultraviscous melt and glassy states of aspirin, ibuprofen, progesterone, and quinidine has been studied by dielectric spectroscopy. The asymmetric relaxation spectra is characterized by the Kohlrausch distribution parameter of 0.46 +/- 0.02 for aspirin to 0.67 +/- 0.02 for progesterone. The dielectric relaxation time varies with the temperature, T, according to the Vogel-Fulcher-Tammann Equation, log(10)(tau(0)) = A(VFT) + [B(VFT)/(T - T(0))], where A(VFT), B(VFT), and T(0) are empirical constants. The extrapolated tau(0) at calorimetric glass-softening temperature is close to the value expected. The equilibrium permittivity, epsilon(0), is lowest for ibuprofen which indicates an antiparallel orientation of dipoles in its liquid's hydrogen-bonded structure. A decrease in epsilon(0) with time shows that ultraviscous aspirin, progesterone, and quinidine begin to cold-crystallize at a relatively lower temperature than ibuprofen. epsilon(0) of the cold-crystallized phases are, 4.7 for aspirin at 290 K, 2.55 for ibuprofen at 287 K, 2.6 for progesterone at 320 K, and 3.2 for quinidine at 375 K. It is argued that hydrogen-bonding, the Kohlrausch parameter, extent of localized motions and the long-range diffusion times all determine the physical and chemical stability of an amorphous pharmaceutical during storage. (c) 2007 Wiley-Liss, Inc. and the American Pharmacists Association.

  4. Calibrated histochemistry applied to oxygen supply and demand in hypertrophied rat myocardium.

    Science.gov (United States)

    Des Tombe, A L; Van Beek-Harmsen, B J; Lee-De Groot, M B E; Van Der Laarse, W J

    2002-09-01

    Oxygen supply and demand of individual cardiomyocytes during the development of myocardial hypertrophy is studied using calibrated histochemical methods. An oxygen diffusion model is used to calculate the critical extracellular oxygen tension (PO(2,crit)) required by cardiomyocytes to prevent hypoxia during hypertrophic growth, and determinants of PO(2,crit) are estimated using calibrated histochemical methods for succinate dehydrogenase activity, cardiomyocyte cross-sectional area, and myoglobin concentration. The model calculation demonstrates that it is essential to calibrate the histochemical methods, so that absolute values for the relevant parameters are obtained. The succinate dehydrogenase activity, which is proportional to the maximum rate of oxygen consumption, and the myoglobin concentration hardly change while the cardiomyocytes grow. The cross-sectional area of the cardiomyocytes, which increases up to threefold in the right ventricular wall due to pulmonary hypertension in monocrotaline-treated rats, is the most important determinant of PO(2,crit) in this model of myocardial hypertrophy. The relationship between oxygen supply and demand at the level of the cardiomyocyte can be investigated using paired determinations of spatially integrated succinate dehydrogenase activity and capillary density. Hypoxia-inducible factor 1alpha can be demonstrated by immunohistochemistry in cardiomyocytes with high PO(2,crit) and increased spatially integrated succinate dehydrogenase activity, indicating that limited oxygen supply affects gene expression in these cells. We conclude that a mismatch of oxygen supply and demand may develop during hypertrophic growth, which can play a role in the transition from myocardial hypertrophy to heart failure. Copyright 2002 Wiley-Liss, Inc.

  5. A cloud mask methodology for high resolution remote sensing data combining information from high and medium resolution optical sensors

    Science.gov (United States)

    Sedano, Fernando; Kempeneers, Pieter; Strobl, Peter; Kucera, Jan; Vogt, Peter; Seebach, Lucia; San-Miguel-Ayanz, Jesús

    2011-09-01

    This study presents a novel cloud masking approach for high resolution remote sensing images in the context of land cover mapping. As an advantage to traditional methods, the approach does not rely on thermal bands and it is applicable to images from most high resolution earth observation remote sensing sensors. The methodology couples pixel-based seed identification and object-based region growing. The seed identification stage relies on pixel value comparison between high resolution images and cloud free composites at lower spatial resolution from almost simultaneously acquired dates. The methodology was tested taking SPOT4-HRVIR, SPOT5-HRG and IRS-LISS III as high resolution images and cloud free MODIS composites as reference images. The selected scenes included a wide range of cloud types and surface features. The resulting cloud masks were evaluated through visual comparison. They were also compared with ad-hoc independently generated cloud masks and with the automatic cloud cover assessment algorithm (ACCA). In general the results showed an agreement in detected clouds higher than 95% for clouds larger than 50 ha. The approach produced consistent results identifying and mapping clouds of different type and size over various land surfaces including natural vegetation, agriculture land, built-up areas, water bodies and snow.

  6. Summary of contributions to GAW Group 15: family-based samples are useful in identifying common polymorphisms associated with complex traits.

    Science.gov (United States)

    Knight, Stacey; Uh, Hae-Won; Martinez, Maria

    2009-01-01

    Traditionally, family-based samples have been used for genetic analyses of single-gene traits caused by rare but highly penetrant risk variants. The utility of family-based genetic data for analyzing common complex traits is unclear and contains numerous challenges. To assess the utility as well as to address these challenges, members of Genetic Analysis Workshop 16 Group 15 analyzed Framingham Heart Study data using family-based designs ranging from parent--offspring trios to large pedigrees. We investigated different methods including traditional linkage tests, family-based association tests, and population-based tests that correct for relatedness between subjects, and tests to detect parent-of-origin effects. The analyses presented an assortment of positive findings. One contribution found increased power to detect epistatic effects through linkage using ascertainment of sibships based on extreme quantitative values or presence of disease associated with the quantitative value. Another contribution found four single-nucleotide polymorphisms (SNPs) showing a maternal effect, two SNPs with an imprinting effect, and one SNP having both effects on a binary high blood pressure trait. Finally, three contributions illustrated the advantage of using population-based methods to detect association to complex binary or quantitative traits. Our findings highlight the contribution of family-based samples to the genetic dissection of complex traits. (c) 2009 Wiley-Liss, Inc.

  7. Magnetic field shift due to mechanical vibration in functional magnetic resonance imaging.

    Science.gov (United States)

    Foerster, Bernd U; Tomasi, Dardo; Caparelli, Elisabeth C

    2005-11-01

    Mechanical vibrations of the gradient coil system during readout in echo-planar imaging (EPI) can increase the temperature of the gradient system and alter the magnetic field distribution during functional magnetic resonance imaging (fMRI). This effect is enhanced by resonant modes of vibrations and results in apparent motion along the phase encoding direction in fMRI studies. The magnetic field drift was quantified during EPI by monitoring the resonance frequency interleaved with the EPI acquisition, and a novel method is proposed to correct the apparent motion. The knowledge on the frequency drift over time was used to correct the phase of the k-space EPI dataset. Since the resonance frequency changes very slowly over time, two measurements of the resonance frequency, immediately before and after the EPI acquisition, are sufficient to remove the field drift effects from fMRI time series. The frequency drift correction method was tested "in vivo" and compared to the standard image realignment method. The proposed method efficiently corrects spurious motion due to magnetic field drifts during fMRI. (c) 2005 Wiley-Liss, Inc.

  8. Cardiac MRI to investigate myocardial scar and coronary venous anatomy using a slow infusion of dimeglumine gadobenate in patients undergoing assessment for cardiac resynchronization therapy.

    Science.gov (United States)

    Duckett, Simon G; Chiribiri, Amedeo; Ginks, Matthew R; Sinclair, Stephen; Knowles, Benjamin R; Botnar, Rene; Carr-White, Gerry S; Rinaldi, Christopher A; Nagel, Eike; Razavi, Reza; Schaeffter, Tobias

    2011-01-01

    To evaluate a cardiac MR (CMR) examination with slow infusion of a high-relaxivity contrast agent to visualize coronary venous anatomy (CVA) and myocardial scar in heart failure patients awaiting cardiac resynchronization therapy (CRT). Fourteen patients awaiting CRT (seven ischemic cardiomyopathy (ICM) and seven non-ICM) and two with normal LV function underwent CMR on a 1.5 Tesla (T) MR scanner. Dimeglumine-gadobenate was slowly infused. Bolus arrival in the LV was measured by a dynamic electrocardiogram (ECG) -triggered inversion recovery (IR) scan subsequent to starting an ECG-triggered respiratory-navigated three-dimensional (3D) SSFP MR scan with IR preparation to acquire systolic whole-heart anatomy for vein visualization. Delayed contrast-enhanced MR scan was performed to assess myocardial scar. CVA obtained by CMR was compared with X-ray venography in 11 patients. CVA and scar were segmented and registered for visual inspection. For all subjects, there was excellent visualization of the CVA. All ICM and one non-ICM patient showed scar. There was excellent correlation between veins seen by CMR and venography. We have demonstrated that slow infusion protocol of dimeglumine-gadobenate can be used to assess both CVA and myocardial scar in a single MR examination. Furthermore, an image overlay technique has been used to show the relationship of scar to the CVA. Copyright © 2010 Wiley-Liss, Inc.

  9. Outcomes of genetics services: creating an inclusive definition and outcomes menu for public health and clinical genetics services.

    Science.gov (United States)

    Silvey, Kerry; Stock, Jacquie; Hasegawa, Lianne E; Au, Sylvia Mann

    2009-08-15

    Third party payers, funding agencies, and lawmakers often require clinicians and public health agencies to justify programs and services by documenting results. This article describes two assessment tools--"Defining Genetics Services Framework" and "Genetics Services Outcomes Menu," created to assist public health professionals, clinicians, family advocates, and researchers to plan, evaluate, and demonstrate the effectiveness of genetics services. The tools were developed by a work group of the Western States Genetics Services Collaborative (WSGSC) consisting of public health genetics and newborn screening professionals, family representatives, a medical geneticist, and genetic counselors from Alaska, California, Hawaii, Idaho, Oregon, and Washington. The work group created both tools by an iterative process of combining their ideas with findings from a literature and World Wide Web review. The Defining Genetics Services Framework reflects the diversity of work group members. Three over-lapping areas of genetics services from public health core functions to population screening to clinical genetics services are depicted. The Genetics Services Outcomes Menu lists sample long-term outcomes of genetics services. Menu outcomes are classified under impact areas of Knowledge and Information; Financing; Screening and Identification; Diagnosis, Treatment, and Management; and Population Health. The WSGSC incorporated aspects of both tools into their Regional Genetics Plan. 2009 Wiley-Liss, Inc.

  10. LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01).

    Science.gov (United States)

    Avettand-Fènoël, Véronique; Chaix, Marie-Laure; Blanche, Stéphane; Burgard, Marianne; Floch, Corinne; Toure, Kadidia; Allemon, Marie-Christine; Warszawski, Josiane; Rouzioux, Christine

    2009-02-01

    HIV-1 diagnosis in babies born to seropositive mothers is one of the challenges of HIV epidemics in children. A simple, rapid protocol was developed for quantifying HIV-1 DNA in whole blood samples and was used in the ANRS French pediatric cohort in conditions of prevention of mother-to-child transmission. A quantitative HIV-1 DNA protocol (LTR real-time PCR) requiring small blood volumes was developed. First, analytical reproducibility was evaluated on 172 samples. Results obtained on blood cell pellets and Ficoll-Hypaque separated mononuclear cells were compared in 48 adult HIV-1 samples. Second, the protocol was applied to HIV-1 diagnosis in infants in parallel with plasma HIV-RNA quantitation. This prospective study was performed in children born between May 2005 and April 2007 included in the ANRS cohort. The assay showed good reproducibility. The 95% detection cut-off value was 6 copies/PCR, that is, 40 copies/10(6) leukocytes. HIV-DNA levels in whole blood were highly correlated with those obtained after Ficoll-Hypaque separation (r = 0.900, P mothers have received HAART. (c) 2008 Wiley-Liss, Inc.

  11. Sampling in research on interpersonal aggression.

    Science.gov (United States)

    Nielsen, Morten Birkeland; Einarsen, Ståle

    2008-01-01

    The aim of this study was to investigate the usefulness of convenience samples in research on interpersonal aggression among adults. It was hypothesised that convenience sampled targets of aggression differs from targets in general with regards to both demographic characteristics and degree of aggression exposed to. A convenience sample comprising support-seeking targets of workplace bullying was compared with a representative sample of Norwegian targets of bullying. The results showed that the two samples differed significantly on all demographic variables investigated, except gender. A far higher percentage of the convenience sample had blown the whistle on illegal, immoral or illegitimate practice at their workplace, whereas they also reported significantly more frequent and more intense exposure to aggression. The findings confirm that convenience samples have low external validity when generalising to the general population. Such samples should therefore mainly be used to investigate tendencies in, and the phenomenology of, interpersonal aggression, in studies where generalisability is not the principal objective. Copyright 2007 Wiley-Liss, Inc.

  12. Synthesis and characterization of a cytotoxic cationic polyvinylpyrrolidone-curcumin conjugate.

    Science.gov (United States)

    Manju, S; Sreenivasan, K

    2011-02-01

    Curcumin has been studied as a potential drug for many diseases including cancer. One of the serious limitations projected on curcumin is its poor water solubility and the substantially low bioavailability. With a view to enhance the aqueous solubility of curcumin, we synthesized polyvinylpyrrolidone-curcumin conjugates. Polyvinylpyrrolidone was used for the conjugation considering its long history of safe usage as a biomaterial for various medical applications. The drug conjugates self-assembled in aqueous solution to form nanosized micellar aggregates. The formation of micellae stabilized curcumin against hydrolytic degradation. Another interesting feature of the conjugate was its cationic nature. The net zeta potential in the pH range from 3 to 7.4 was +25 to +20 mV, reflecting the potential stability of the conjugate micellae at physiological pH. We quantified cytotoxic potential of the conjugate by the MTT assay, using L929 fibroblast cells. The results showed that the conjugate had higher cytotoxicity than that of the free curcumin. It is expected that the relative enhanced cytotoxicities are the result of enhanced aqueous solubility and polymer-mediated drug internalization. The conjugate has the potential to circumvent limitations of curcumin and thereby to extrapolate further its applications as an effective anticancer drug. Copyright © 2010 Wiley-Liss, Inc.

  13. A survey of language barriers from the perspective of pediatric oncologists, interpreters, and parents.

    Science.gov (United States)

    Abbe, Marisa; Simon, Christian; Angiolillo, Anne; Ruccione, Kathy; Kodish, Eric D

    2006-11-01

    Oncologists in the US increasingly face the challenge of communicating with non-English speaking parents of children with cancer. This study explores this challenge from the perspectives of a sample of pediatric oncologists, interpreters, and Spanish-speaking parents of children with newly diagnosed leukemia. Thirty-seven oncologists and 17 professional language interpreters based at two non-profit pediatric hospitals in the US were surveyed on the topic of language barriers in pediatric care. Seventeen parents who communicated with their child's oncologist through an interpreter were also surveyed. All groups expressed considerable concern over the process of communicating across a language barrier. For oncologists, these concerns included the accuracy and completeness of interpretations, complexity of information, and loss of confidence and control over the communication process. For interpreters, they included complexity of information, information overload, and lack of clinician sensitivity toward the cultural and socioeconomic backgrounds of limited English proficiency (LEP) families. Parent concerns included difficulties comprehending information and anxiety over the possibility of missing out on important information. All groups provided multiple suggestions for improving communication across a language barrier. Oncologists, interpreters, and parents expressed considerable concern over the process of communicating across a language barrier. Some of these concerns could be minimized through efforts to boost interpreter accuracy and completeness, including the use of more simple, easy to understand language. Other issues, such as differences in culture and socioeconomic background, warrant consideration of the intercultural knowledge and skills of interpreters. (c) 2006 Wiley-Liss, Inc.

  14. Capital punishment and anatomy: history and ethics of an ongoing association.

    Science.gov (United States)

    Hildebrandt, S

    2008-01-01

    Anatomical science has used the bodies of the executed for dissection over many centuries. As anatomy has developed into a vehicle of not only scientific but also moral and ethical education, it is important to consider the source of human bodies for dissection and the manner of their acquisition. From the thirteenth to the early seventeenth century, the bodies of the executed were the only legal source of bodies for dissection. Starting in the late seventeenth century, the bodies of unclaimed persons were also made legally available. With the developing movement to abolish the death penalty in many countries around the world and with the renunciation of the use of the bodies of the executed by the British legal system in the nineteenth century, two different practices have developed in that there are Anatomy Departments who use the bodies of the executed for dissection or research and those who do not. The history of the use of bodies of the executed in German Anatomy Departments during the National Socialist regime is an example for the insidious slide from an ethical use of human bodies in dissection to an unethical one. There are cases of contemporary use of unclaimed or donated bodies of the executed, but they are rarely well documented. The intention of this review is to initiate an ethical discourse about the use of the bodies of the executed in contemporary anatomy. (c) 2007 Wiley-Liss, Inc.

  15. Why do flamingos stand on one leg?

    Science.gov (United States)

    Anderson, Matthew J; Williams, Sarah A

    2010-01-01

    A series of observational studies of captive Caribbean flamingos Phoenicopterus ruber were conducted to determine why flamingos rest on one leg. While frequently asked by the general public, this basic question has remained unanswered by the scientific community. Here we suggest that the latency of flamingos to initiate forward locomotion following resting on one leg is significantly longer than following resting on two, discounting the possibility that unipedal resting reduces muscle fatigue or enhances predatory escape. Additionally, we demonstrate that flamingos do not display lateral preferences at the individual or group levels when resting on one leg, with each bird dividing its resting time across both legs. We show that while flamingos prefer resting on one leg to two regardless of location, the percentage of birds resting on one leg is significantly higher among birds standing in the water than among those on land. Finally, we demonstrate a negative relationship between temperature and the percentage of observed birds resting on one leg, such that resting on one leg decreases as temperature rises. Results strongly suggest that unipedal resting aids flamingos in thermoregulation. (c) 2009 Wiley-Liss, Inc.

  16. Confusing dinosaurs with mammals: tetrapod phylogenetics and anatomical terminology in the world of homology.

    Science.gov (United States)

    Harris, Jerald D

    2004-12-01

    At present, three different systems of anatomical nomenclature are available to researchers describing new tetrapod taxa: a nonstandardized traditional system erected in part by Sir Richard Owen and subsequently elaborated by Alfred Romer; a standardized system created for avians, the Nomina Anatomica Avium (NAA); and a standardized system for extant (crown-group) mammals, the Nomina Anatomica Veterinaria (NAV). Conserved homologous structures widely distributed within the Tetrapoda are often granted different names in each system. The recent shift toward a phylogenetic system based on homology requires a concomitant shift toward a single nomenclatural system also based on both evolutionary and functional morphological homology. Standardized terms employed in the NAA and NAV should be perpetuated as far as possible basally in their respective phylogenies. Thus, NAA terms apply to nonavian archosaurs (or even all diapsids) and NAV terms apply to noncrown-group mammals and more basal synapsids. Taxa equally distant from both avians and crown-group mammals may maintain the traditional nonstandardized terminology until a universal anatomical nomenclature for all tetrapods is constructed. (c) 2004 Wiley-Liss, Inc.

  17. Quantitative analysis of Neanderthal temporal bone morphology using three-dimensional geometric morphometrics.

    Science.gov (United States)

    Harvati, Katerina

    2003-04-01

    The temporal bone is the location of several traits thought to differentiate Neanderthals from modern humans, including some proposed Neanderthal-derived traits. Most of these, however, are difficult to measure and are usually described qualitatively. This study applied the techniques of geometric morphometrics to the complex morphology of the temporal bone, in order to quantify the differences observed between Neanderthal and modern human anatomy. Two hundred and seventy modern human crania were measured, representing 9 populations of 30 individuals each, and spanning the extremes of the modern human geographical range. Twelve Neanderthal specimens, as well as Reilingen, Kabwe, Skhul 5, Qafzeh 9, and 4 Late Paleolithic European specimens, were included in the fossil sample. The data were collected in the form of three-dimensional (3-D) landmark coordinates, and specimen configurations were superimposed using generalized Procrustes analysis. The fitted coordinates were then analyzed by an array of multivariate statistical methods, including principal components analysis, canonical variates analysis, and Mahalanobis D(2). The temporal bone landmark analysis was very successful in separating Neanderthals from modern humans. Neanderthals were separated from modern humans in both the principal components and canonical variates analyses. They were much further in Mahalanobis distances from all modern human populations than any two modern human groups were from each other. Most of the previously described temporal bone traits contributed to this separation. Copyright 2003 Wiley-Liss, Inc.

  18. Genetic linkage of bipolar disorder to chromosome 6q22 is a consistent finding in Portuguese subpopulations and may generalize to broader populations.

    Science.gov (United States)

    Pato, Carlos N; Middleton, Frank A; Gentile, Karen L; Morley, Christopher P; Medeiros, Helena; Macedo, Antonio; Azevedo, M Helena; Pato, Michele T

    2005-04-05

    We recently reported genome-wide significant linkage to chromosome 6q for bipolar disorder, in a study of 25 Portuguese families, using the Human Mapping Assay Xba 131 (HMA10K). To explore the generalizability of this finding, we reanalyzed our SNP linkage data according to the families' geographic origin. Specifically, the 25 families included 20 families from the Portuguese island collection (PIC; 15 families from the Azores Islands and 5 from the Madeira Islands) and 5 families from continental Portugal. Non-parametric linkage analysis (NPL) was performed as previously described and indicated that each of these subpopulations showed evidence of linkage for the same region. To further address the potential generalizability of these findings to other populations, we have also examined allelic heterozygosity in our subpopulations and in three reference populations (Caucasian, East Asian, and African-American). This analysis indicated that the PIC population is highly correlated to the Caucasian reference population (R = 0.86) for all of chromosome 6. In contrast allelic heterozygosity was more weakly correlated between PIC and both East Asian (R = 0.37) and African-American (R = 0.32) reference populations. Taken together these observations suggest a shared genetic liability among Portuguese populations for bipolar disorder on chromosome 6q, and that the PIC population is likely representative of Caucasians in general. Copyright 2005 Wiley-Liss, Inc.

  19. Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches.

    Science.gov (United States)

    Middleton, Frank A; Pato, Carlos N; Gentile, Karen L; McGann, Lindsay; Brown, Andrea M; Trauzzi, Marco; Diab, Heba; Morley, Christopher P; Medeiros, Helena; Macedo, Antonio; Azevedo, M Helena; Pato, Michele T

    2005-07-05

    We performed global RNA transcript analysis and comprehensive gene group analysis of peripheral blood leukocyte (PBL) RNA from two groups of matched sib-pairs that were discordant for either schizophrenia (n = 33 sib-pairs) or bipolar disorder (n = 5 sib-pairs). The pairs chosen for these analyses were selected from families with known patterns of genetic linkage (5q for schizophrenia and 6q for bipolar disorder). At the single gene level, we obtained lists of the transcripts with the most significant changes in expression and from these lists determined those with the highest degree of predictive power for classifying subjects according to diagnosis in these samples. At the gene group level, we comprehensively analyzed pairwise expression changes of more than 4,000 functional groups and cytogenetic locations, and present a novel method of displaying these data that we term "cytogenomic" mapping. Verification of selected changes in expression was performed using quantitative real-time RT-PCR. Our results provide compelling evidence for the utility of analyzing PBL RNA for changes in expression in neuropsychiatric disorders. Copyright 2005 Wiley-Liss, Inc.

  20. Lack of association or linkage disequilibrium between schizophrenia and polymorphisms in the 5-HT1Dalpha and 5-HT1Dbeta autoreceptor genes: family-based association study.

    Science.gov (United States)

    Ambrósio, Alda M; Kennedy, James L; Macciardi, Fabio; Coelho, Isabel; Soares, Maria J; Oliveira, Catarina R; Pato, Carlos N

    2004-07-01

    Genetic factors play a major role in the etiology of schizophrenia and disturbances of serotonergic pathways have been implicated in this disorder. The aim of the present study was to examine genetic association between schizophrenia and polymorphisms in the 5-HT1Dalpha (TaqI) and 5-HT1Dbeta (T261G and G861C) autoreceptor genes in ninety trios from Portugal. No association or linkage disequilibrium was obtained between schizophrenia and 5-HT1Dalpha and 5-HT1Dbeta autoreceptor genes with both haplotype relative risk (HRR) and transmission disequilibrium test (TDT). Concerning 5-HT1Dbeta autoreceptor gene, also negative results was obtained in the analysis of the haplotypes with transmit. Thus, our data provide no support for the hypothesis that polymorphisms at 5-HT1Dalpha (TaqI) and 5-HT1Dbeta (T261G and G861C) genes contributes to susceptibility to schizophrenia in the Portuguese population. Copyright 2004 Wiley-Liss, Inc.

  1. Land use and water quality degradation in the Peixe-Boi River watershed

    Directory of Open Access Journals (Sweden)

    Bruno Wendell de Freitas Pereira

    2016-04-01

    Full Text Available This study mapped the land use and land cover of the catchment area of the Peixe-Boi River watershed, in northeast Pará, in order to identify conflicts of land use in the permanent preservation areas, and to relate them to water quality. We used LISS-3 sensor imagery from the Resourcesat satellite with a spatial resolution of 23.5 m for supervised classification of land use and land cover based on 22 training samples. Water quality was determined based on 28 sampling points in drainage network. The relationship between human disturbance and water quality was analyzed based on observations of land use changes using satellite imagery and in situ collection of water samples. The results show that 46% of the permanent preservation areas have conflicted uses, especially with respect to urban squatters, exposed soil and, most notably, pasture, with over 84 % of the area in conflict. Critical levels of dissolved oxygen reaching 2.14 mg L-1 and pH of 5.12 were observed in some sampling points. These values are below the fresh water standards set by Resolution 357/05 of CONAMA. The poorest water quality may be related to irregular use and occupation of areas within the permanent preservation areas. There is therefore an urgent need to develop a plan for the sustainable use and occupation of catchment area land in the Peixe-Boi River watershed in order to restore the environment and improve water quality.

  2. Precise conditional immortalization of mouse cells using tetracycline-regulated SV40 large T-antigen.

    Science.gov (United States)

    Anastassiadis, Konstantinos; Rostovskaya, Maria; Lubitz, Sandra; Weidlich, Stefanie; Stewart, A Francis

    2010-04-01

    Cellular immortalization provides a way for expansion and subsequent molecular characterization of rare cell types. Ideally, immortalization can be achieved by the reversible expression of immortalizing proteins. Here, we describe the use of conditional immortalization based on a modified tetracycline-regulated system for the expression of SV40 large T-antigen in embryonic stem (ES) cells and mice. The modified system relies on a codon improved reverse tetracycline transactivator (irtTA) fused to the ligand-binding domain (LBD) of the androgen receptor (irtTA-ABD) or of a mutated glucocorticoid receptor (irtTA-GBD*). Induction of T-antigen is conferred only after addition of two ligands, one to activate the LBD (mibolerone for irtTA-ABD or dexamethasone for irtTA-GBD*) and one to activate the tetracycline transactivator (doxycycline). In ES cells, changes in gene expression upon large T induction were limited and reversible upon deinduction. Similarly, expression of T-antigen was very tightly regulated in mice. We have isolated and expanded bone marrow mesenchymal stem cells that could be genetically manipulated and maintained their differentiation properties after several passages of expansion under conditions that induce the expression of large T-antigen. 2010 Wiley-Liss, Inc.

  3. Analysis of reactive oxygen species in the guard cell of wheat stoma with confocal microscope.

    Science.gov (United States)

    Liu, Dongwu; Chen, Zhiwei; Shi, Peiguo; Wang, Xue; Cai, Weiwei

    2011-09-01

    Recently, the laser-scanning confocal microscope has become a routine technique and indispensable tool for cell biological studies. Previous studies indicated that reactive oxygen species (ROS) were generated in tobacco epidermal cells with confocal microscope. In the present studies, the probe 2',7'-dichlorof luorescein diacetate (H₂DCF-DA) was used to research the change of ROS in the guard cell of wheat stoma, and catalase (CAT) was used to demonstrate that ROS had been labeled. The laser-scanning mode of confocal microscope was XYT, and the time interval between two sections was 1.6351 s. Sixty optical sections were acquired with the laser-scanning confocal microscope, and CAT (60,000 U mg⁻¹) was added after four optical sections were scanned. Furthermore, the region of interest (ROI) was circled and the fluorescence intensity of ROS was quantified with Leica Confocal Software. The quantitative data were exported and the trend chart was made with software Excell. The results indicated that ROS were produced intracellularly in stomatal guard cells, and the quantified fluorescence intensity of ROS was declined with CAT added. It is a good method to research the instantaneous change of ROS in plant cells with confocal microscope and fluorescence probe H₂DCF-DA. Copyright © 2010 Wiley-Liss, Inc.

  4. Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome.

    Science.gov (United States)

    Murphy, Clodagh M; Deeley, Q; Daly, E M; Ecker, C; O'Brien, F M; Hallahan, B; Loth, E; Toal, F; Reed, S; Hales, S; Robertson, D M; Craig, M C; Mullins, D; Barker, G J; Lavender, T; Johnston, P; Murphy, K C; Murphy, D G

    2012-02-01

    It has been proposed that people with autism spectrum disorder (ASD) have abnormal morphometry and development of the amygdala and hippocampus (AH). However, previous reports are inconsistent, perhaps because they included people of different ASD diagnoses, ages, and health. We compared, using magnetic resonance imaging, the in vivo anatomy of the AH in 32 healthy individuals with Asperger syndrome (12-47 years) and 32 healthy controls who did not differ significantly in age or IQ. We measured bulk (gray + white matter) volume of the AH using manual tracing (MEASURE). We first compared the volume of AH between individuals with Asperger syndrome and controls and then investigated age-related differences. We compared differences in anatomy before, and after, correcting for whole brain size. There was no significant between group differences in whole brain volume. However, individuals with Asperger syndrome had a significantly larger raw bulk volume of total (PAsperger syndrome, had a significant age-related increase in volume (r = 0.486, PAsperger syndrome have significant differences from controls in bulk volume and aging of the amygdala. Copyright © 2011, International Society for Autism Research, Wiley-Liss, Inc.

  5. Expression of muscle-specific myosin heavy chain and myosin light chain 1 in the electric tissue of Electrophorus electricus (L.) in comparison with other vertebrate species.

    Science.gov (United States)

    Ayres Sá, L; Menezes, M A; dos Santos Mermelstein, C

    2001-08-01

    Myosin light and heavy chains from skeletal and cardiac muscles and from the electric organ of Electrophorus electricus (L.) were characterised using biochemical and immunological methods, and compared with myosin extracted from avian, reptilian, and mammalian skeletal and cardiac muscles. The results indicate that the electric tissue has a myosin light chain 1 (LC1) and a muscle-specific myosin heavy chain. We also show that monoclonal antibody F109-12A8 (against LC1 and LC2) recognizes LC1 of myosin from human skeletal and cardiac muscles as well as those of rabbit, lizard, chick, and electric eel. However, only cardiac muscles from humans and rabbits have LC2, which is recognized by antibody F109-16F4. The data presented confirm the muscle origin of the electric tissue of E. electricus. This electric tissue has a profile of LC1 protein expression that resembles the myosin from cardiac muscle of the eel more than that from eel skeletal muscle. This work raises an interesting question about the ontogenesis and differentiation of the electric tissue of E. electricus. Copyright 2001 Wiley-Liss, Inc.

  6. Gadolinium-containing magnetic resonance image contrast agent promotes fibrocyte differentiation.

    Science.gov (United States)

    Vakil, Varsha; Sung, Joanna J; Piecychna, Marta; Crawford, Jeffrey R; Kuo, Phillip; Abu-Alfa, Ali K; Cowper, Shawn E; Bucala, Richard; Gomer, Richard H

    2009-12-01

    Gadolinium-containing magnetic resonance imaging (MRI) contrast agents such as Omniscan are associated with nephrogenic systemic fibrosis (NSF). To determine if Omniscan can affect the differentiation of monocytes into fibroblast-like cells called fibrocytes that are found in the fibrotic lesions of NSF, peripheral blood mononuclear cells (PBMCs) from NSF patients, hemodialysis patients without NSF, and healthy, renally sufficient controls were exposed to Omniscan in a standardized in vitro fibrocyte differentiation protocol. When added to PBMCs, the gadolinium-containing MRI contrast agent Omniscan generally had little effect on fibrocyte differentiation. However, 10(-8) to 10(-3) mg/mL Omniscan reduced the ability of the fibrocyte differentiation inhibitor serum amyloid P (SAP) to decrease fibrocyte differentiation in PBMCs from 15 of 17 healthy controls and one of three NSF patients. Omniscan reduced the ability of SAP to decrease fibrocyte differentiation from purified monocytes, indicating that the Omniscan effect does not require the presence of other cells (such as T cells) in the PBMCs. Omniscan also reduced the ability of a different fibrocyte differentiation inhibitor, interleukin-12, to decrease fibrocyte differentiation. These data suggest that Omniscan interferes with the regulatory action of signals that inhibit the differentiation of monocytes to fibrocytes. J. Magn. Reson. Imaging 2009;30:1284-1288. (c) 2009 Wiley-Liss, Inc.

  7. Quantitative analysis of regional airways obstruction using dynamic hyperpolarized 3He MRI-preliminary results in children with cystic fibrosis.

    Science.gov (United States)

    Koumellis, Panos; van Beek, Edwin J R; Woodhouse, Neil; Fichele, Stan; Swift, Andrew J; Paley, Martyn N J; Hill, Catherine; Taylor, Chris J; Wild, Jim M

    2005-09-01

    To investigate regional airways obstruction in patients with cystic fibrosis (CF) with quantitative analysis of dynamic hyperpolarized (HP) (3)He MRI. Dynamic radial projection MRI of HP (3)He gas was used to study respiratory dynamics in a group of eight children with CF. Signal kinetics in a total of seven regions of interest (ROIs; three in each lung, and one in the trachea) were compared with the results of spirometric pulmonary function tests (PFTs). The tracheal signal intensity was used as a form of "input function" to normalize for input flow effects. A pattern of low flow rate in the upper lobes was observed. When the flow measurements from the peripheral ROIs were averaged to obtain an index of flow in the peripheral lung, a good correlation was found (P = 3.74 x 10(-5)) with the forced expired volume in one second (FEV1). These results suggest that a quantitative measurement of localized airways obstruction in the early stages of CF may be obtained from dynamic (3)He MRI by using the slope of the signal rise as a measure of air flow into the peripheral lung. This study also demonstrates that children can cooperate well with the (3)He MRI technique. (c) 2005 Wiley-Liss, Inc.

  8. CSPP and CSPP-L associate with centrosomes and microtubules and differently affect microtubule organization.

    Science.gov (United States)

    Patzke, Sebastian; Stokke, Trond; Aasheim, Hans-Christian

    2006-10-01

    We recently described the identification of a centrosome/spindle pole associated protein, CSPP, involved in cell cycle progression. Here we report a CSPP isoform denoted CSPP-L, with a 294 amino acids longer N-terminus and a 51 amino acids insertion located in the coiled-coil mid-domain. Expression analysis indicates an inverse cell cycle dependent regulation. CSPP mRNA expression is highest in G1 whereas CSPP-L expression is highest in G2/M. Ectopic expression of CSPP-L impairs cell cycle progression weaker in G1 than CSPP. Furthermore, normal mitotic phenotypes were observed in CSPP-L but not in CSPP transfectants. CSPP-L relocates from spindle microtubules and poles in metaphase to the mid-spindle in anaphase and concentrates at the mid-body in telophase/cytokinesis. CSPP-L high-expressing mitotic cells were predominantly characterized by lagging chromosomes or monopolar spindles, in contrast to the predominant multipolar spindles observed with CSPP expression. The different effects of CSPP and CSPP-L on microtubule organization in mitosis depend on the coiled-coil mid-domain insertion. The common C-terminal domain is required to repress that activity until mitosis. Notably, this C-terminal domain alone can associate with centrosomes in a microtubule independent manner. Taken together, CSPP and CSPP-L interact with centrosomes and microtubules and can differently affect microtubule organization. Copyright 2006 Wiley-Liss, Inc.

  9. Is the prediction of pKa values by constant-pH molecular dynamics being hindered by inherited problems?

    Science.gov (United States)

    Machuqueiro, Miguel; Baptista, António M

    2011-12-01

    In this study, we investigate two factors that can hinder the performance of constant-pH molecular dynamics methods in predicting protein pK(a) values, using hen egg white lysozyme as a test system. The first factor is related to the molecular definition and pK(a) value of model compounds in the Poisson-Boltzmann framework. We address this by defining the model compound as a molecular fragment with an associated pK(a) value that is calibrated against experimental data, which results in a decrease of 0.12 units in pK(a) errors. The second addressed factor is the possibility that detrimental structural distortions are being introduced in the simulations by the underlying molecular mechanics force field. This issue is investigated by analyzing how the gradual structural rearrangements affect the predicted pK(a) values. The two GROMOS force fields studied here (43A1 and 53A6) yield good pK(a) predictions, although a time-dependent performance is observed: 43A1 performs better after a few nanoseconds of structural reorganization (pK(a) errors of ~0.45), while 53A6 gives the best prediction right at the first nanosecond (pK(a) errors of 0.42). These results suggest that the good performance of constant-pH molecular dynamics methods could be further improved if these force field limitations were overcome. Copyright © 2011 Wiley-Liss, Inc.

  10. Primitive versus derived traits in the developmental program of the vertebrate head: views from cyclostome developmental studies.

    Science.gov (United States)

    Kuratani, Shigeru; Ota, Kinya G

    2008-06-15

    Evolution can be viewed as a series of changes in the developmental program along the phylogenetic tree. To better understand the early evolution of the vertebrate skull, we can use the embryos of the cyclostome species as models. By comparing the cyclostome developmental patterns with those of gnathostomes, it becomes possible to distinguish the primitive and derived parts of the developmental program as taxon-specific traits. These traits are often recognizable as developmental constraints that define taxa by biasing the developmental trajectories within a certain limited range, resulting in morphological homologies in adults. These developmental constraints are distributed on the phylogenetic tree like the morphological character states of adult animals and are associated with specific regions of the tree. From this perspective, we emphasize the importance of considering gene expression and embryonic anatomy as the mechanistic bases that can result in homologous or nonhomologous morphological patterns at later developmental stages. Taking the acquisition of the jaw and trabecula cranii as examples, we demonstrate that a set of embryonic features can be coupled or decoupled during evolution and development. When they are coupled, they exert an ancestral developmental constraint that results in homologous morphological patterns, and when they are decoupled, the ancestral constraints tend to be abandoned, generating a new body plan. The heterotopy behind the specification of the oral domain is an example of decoupling, based on shifted tissue interactions. We also stress the importance of "developmental burden" in determining the sequential order of changes through evolution. (c) 2007 Wiley-Liss, Inc.

  11. Evidence for a common biological basis of the Absorption trait, hallucinogen effects, and positive symptoms: epistasis between 5-HT2a and COMT polymorphisms.

    Science.gov (United States)

    Ott, Ulrich; Reuter, Martin; Hennig, Juergen; Vaitl, Dieter

    2005-08-05

    Absorption represents a disposition to experience altered states of consciousness characterized by intensively focused attention. It is correlated with hypnotic susceptibility and includes phenomena ranging from vivid perceptions and imaginations to mystical experiences. Based on the assumption that drug-induced and naturally occurring mystical experiences share common neural mechanisms, we hypothesized that Absorption is influenced by the T102C polymorphism affecting the 5-HT2a receptor, which is known to be an important target site of hallucinogens like LSD. Based on the pivotal role ascribed to the prefrontal executive control network for absorbed attention and positive symptoms in schizophrenia, it was further hypothesized that Absorption is associated with the VAL158MET polymorphism of the catechol-O-methyltransferase (COMT) gene affecting the dopaminergic neurotransmitter system. The Tellegen Absorption Scale was administered to 336 subjects (95 male, 241 female). Statistical analysis revealed that the group with the T/T genotype of the T102C polymorphism, implying a stronger binding potential of the 5-HT2a receptor, indeed had significantly higher Absorption scores (F = 10.00, P = 0.002), while no main effect was found for the COMT polymorphism. However, the interaction between T102C and COMT genotypes yielded significance (F = 3.89; P = 0.049), underlining the known functional interaction between the 5-HT and the dopaminergic system. These findings point to biological foundations of the personality trait of Absorption. (c) 2005 Wiley-Liss, Inc.

  12. The global counterfeit drug trade: patient safety and public health risks.

    Science.gov (United States)

    Mackey, Tim K; Liang, Bryan A

    2011-11-01

    Counterfeit drugs are a global problem with significant and well-documented consequences for global health and patient safety, including drug resistance and patient deaths. This multibillion-dollar industry does not respect geopolitical borders, and threatens public health in both rich and resource-poor nations alike. The epidemiology of counterfeits is also wide in breadth and scope, including thousands of counterfeit incidents per year, encompassing all types of therapeutic classes, and employing a complex global supply chain network enabling this illegal activity. In addition, information technologies available through the Internet and sales via online pharmacies have allowed the criminal element to thrive in an unregulated environment of anonymity, deception, and lack of adequate enforcement. Though recent global enforcement efforts have led to arrests of online counterfeit sellers, such actions have not stemmed supplies from illegal online sellers or kept up with their creativity in illegally selling their products. To address this issue, we propose a global policy framework utilizing public-private partnership models with centralized surveillance reporting that would enable cooperation and coordination to combat this global health crisis. Copyright © 2011 Wiley-Liss, Inc.

  13. Are counterfeit or substandard anti-infective products the cause of treatment failure in Papua New Guinea?

    Science.gov (United States)

    Nair, Anita; Strauch, Stefanie; Lauwo, Jackson; Jähnke, Richard W O; Dressman, Jennifer

    2011-11-01

    Counterfeit and substandard products present a big challenge to any national plan or policy devised to improve public health. Poor quality drug products are especially a problem in lower income countries where product information and drug regulation enforcement are scant or absent. The primary aim of the present study was to evaluate the quality of amodiaquine and amoxicillin formulations sold in Papua New Guinea (PNG) and to detect the presence of counterfeit or substandard drugs in circulation, if any. Fourteen samples, collected from five registered pharmacies in Port Moresby, PNG, were subjected to visual inspection, quality control tests, and verification of product authenticity. The quality control tests included weight variation, content uniformity, thin layer chromatography, and dissolution. None of the products complied with all of the evaluation criteria. Two products, one of which was purportedly distributed by a company which proved to be nonexistent, contained no detectable amodiaquine. The present study confirms that counterfeit and substandard amodiaquine and amoxicillin products are finding their way into the distribution chain in Port Moresby, PNG. This quality problem with anti-infective products is of great concern, as it not only exposes patients to poor quality products but also fosters the development of resistant bacterial strains. Copyright © 2011 Wiley-Liss, Inc.

  14. Testing an inference of function from structure: snake vertebrae do the twist.

    Science.gov (United States)

    Moon, B R

    1999-09-01

    The zygapophyses and zygosphene-zygantrum articulations of snake vertebrae are hypothesized to restrict or eliminate vertebral torsion. This hypothesis is apparently based solely on the inference of function from structure, despite the limitations of such inferences, as well as contradictory observations and measurements. In this study, I observed and measured axial torsion in gopher snakes, Pituophis melanoleucus. To examine the structural basis of axial torsion, I measured the vertebral articulation angles along the body and the insertion angles of five epaxial muscles. To examine torsion in a natural behavior, I digitized video images and measured the degree of apparent axial torsion during terrestrial lateral undulation. Finally, I measured the mechanical capacity of the vertebral joints for actual torsion over intervals of 10 vertebrae in fresh, skinned segments of the trunk. Vertebral articulation angles vary up to 30 degrees and are associated with variation in torsional capacity along the trunk. The freely crawling P. melanoleucus twisted up to 2.19 degrees per vertebra, which produced substantial overall torsion when added over several vertebrae. The vertebral joints are mechanically capable of torsion up to 2.89 degrees per joint. Therefore, despite the mechanical restriction imposed by the complex articulations, vertebral torsion occurs in snakes and appears to be functionally important in several natural behaviors. Even in cases in which mechanical function appears to be narrowly constrained by morphology, specific functions should not be inferred solely from structural analyses. Copyright 1999 Wiley-Liss, Inc.

  15. Scanning electron microscopy of the fetal membranes of an oviparous squamate, the corn snake Pituophis guttatus (Colubridae).

    Science.gov (United States)

    Knight, Siobhan M; Blackburn, Daniel G

    2008-08-01

    Although the fetal membranes of viviparous squamates have received much study, morphology of their homologues among oviparous reptiles is poorly understood. The scarcity of information about these membranes in egg-laying reptiles hampers attempts to distinguish specializations for viviparity from ancestral oviparous features. We used scanning electron microscopy to examine fetal membranes of an oviparous snake (Pituophis guttatus) throughout the developmental period from oviposition to hatching. The external surface of the chorion contains broad, flattened cells that lack surface features; these cells form a continuous layer over the allantoic capillaries and offer a minimal barrier to respiratory exchange. In contrast, the surface epithelium of the omphalopleure bears elaborate surface ridges suggestive of absorptive capabilities. These ridges are prominent in the first few weeks after oviposition, but diminish thereafter. During development, the isolated yolk mass (IYM) of the omphalopleure becomes depleted, and the tissue becomes heavily vascularized by allantoic vessels. Surface features of the omphalopleure progressively take on the appearance of the chorioallantois, but the changes are not synchronous with loss of the IYM or membrane vascularization. Previous studies on viviparous snakes suggest that the chorioallantois and omphalopleure are respectively specialized for gas exchange and absorption in the intrauterine environment. Our studies of fetal membranes in P. guttatus offer evidence that cytological specializations for these functions originated under oviparous conditions, reflecting functional capacities that predate viviparity. (c) 2008 Wiley-Liss, Inc.

  16. Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides.

    Science.gov (United States)

    Deo, Monika; Yu, Jenn-Yah; Chung, Kwan-Ho; Tippens, Melissa; Turner, David L

    2006-09-01

    We have developed an in situ hybridization procedure for the detection of microRNAs (miRNAs) in tissue sections from mouse embryos and adult organs. The method uses highly specific washing conditions for RNA oligonucleotide probes conjugated to a fluorescein hapten. We show that this method detects predominantly mature miRNAs rather than the miRNA precursors or primary transcripts. We have determined expression patterns for several miRNAs expressed in the developing and adult nervous system, including miR-124a, miR-9, miR-92, and miR-204. Whereas miR-124a is expressed in neurons, miR-9 is expressed in neural progenitors and some neurons, and miR-204 is expressed in the choroid plexus, retinal pigment epithelium, and ciliary body. miR-204 is located in an intron of the TRPM3 gene, and the TRPM3 mRNA is coexpressed with miR-204 in the choroid plexus. We also find that primary transcripts for miR-124a and miR-9 genes are expressed in patterns similar to their respective mature miRNAs. The ability to visualize expression of specific miRNAs in embryos and tissues should aid studies on miRNA function. Copyright 2006 Wiley-Liss, Inc.

  17. Overexpression of the human major vault protein in astrocytic brain tumor cells.

    Science.gov (United States)

    Berger, W; Spiegl-Kreinecker, S; Buchroithner, J; Elbling, L; Pirker, C; Fischer, J; Micksche, M

    2001-11-01

    Evidence has shown that the major human vault protein (MVP), which is identical to lung resistance-related protein (LRP), may be causally involved in a special type of multidrug resistance (MDR). The purpose of this study was to investigate the expression and cellular localization of MVP in cells derived from brain tumors and other tumors of neuroectodermal origin. Using both established cell lines (n = 22) and primary explants (n = 30), we show that a distinct overexpression of the MVP gene at the mRNA (RT-PCR) and protein (Western blot) levels is a characteristic feature of cells derived from astrocytic brain tumors. Primary cultures obtained from meningioma specimens also expressed high MVP levels, in contrast to neuroblastoma and medulloblastoma cells, which rarely contained detectable amounts of MVP. Normal human astrocytes cultured in vitro expressed MVP, although at low amounts compared with most malignant cell types. Basal MVP expression correlated with resistance against diverse antineoplastic drugs including anthracyclins, cisplatin and etoposide. By Western blot, MVP was also detected in all tumor samples taken from 7 glioma and 3 meningioma patients. Taken together, these data suggest overexpression of MVP as one explanation for the low efficacy of chemotherapeutic treatment of astrocytic brain tumors. Copyright 2001 Wiley-Liss, Inc.

  18. Social psychological processes in family and school: more evidence on their relative etiological significance for bullying behavior.

    Science.gov (United States)

    Idsoe, Thormod; Solli, Elin; Cosmovici, Elena Maria

    2008-01-01

    This study looked at students' perceptions of the three socialization processes of connection, regulation, and autonomy with their parents and teachers, and the relation of these issues to bullying peers. Self-reported data were collected from a representative sample of Norwegian eighth graders (N=2,083, 1,010 boys, and 1,073 girls). Findings partially confirm our hypotheses that we generated from earlier research into general antisocial behavior. For both genders, parent regulation and teacher regulation had a direct impact on bullying behavior. Parent connection and teacher connection also had an impact on bullying behavior, but these effects were indirect and were mediated by regulation and autonomy from parents and teachers. Some of the socialization processes had different impacts on bullying behavior for boys and girls. Parent autonomy and teacher autonomy had impact (although weak) on bullying behavior for boys only. In general, the variables related to the parents were of more importance for bullying behavior than the variables related to the teachers. Copyright 2008 Wiley-Liss, Inc.

  19. Automated protein structure modeling in CASP9 by I-TASSER pipeline combined with QUARK-based ab initio folding and FG-MD-based structure refinement.

    Science.gov (United States)

    Xu, Dong; Zhang, Jian; Roy, Ambrish; Zhang, Yang

    2011-01-01

    I-TASSER is an automated pipeline for protein tertiary structure prediction using multiple threading alignments and iterative structure assembly simulations. In CASP9 experiments, two new algorithms, QUARK and fragment-guided molecular dynamics (FG-MD), were added to the I-TASSER pipeline for improving the structural modeling accuracy. QUARK is a de novo structure prediction algorithm used for structure modeling of proteins that lack detectable template structures. For distantly homologous targets, QUARK models are found useful as a reference structure for selecting good threading alignments and guiding the I-TASSER structure assembly simulations. FG-MD is an atomic-level structural refinement program that uses structural fragments collected from the PDB structures to guide molecular dynamics simulation and improve the local structure of predicted model, including hydrogen-bonding networks, torsion angles, and steric clashes. Despite considerable progress in both the template-based and template-free structure modeling, significant improvements on protein target classification, domain parsing, model selection, and ab initio folding of β-proteins are still needed to further improve the I-TASSER pipeline. Copyright © 2011 Wiley-Liss, Inc.

  20. HERV-mediated genomic rearrangement of EYA1 in an individual with branchio-oto-renal syndrome.

    Science.gov (United States)

    Sanchez-Valle, Amarilis; Wang, Xueqing; Potocki, Lorraine; Xia, Zhilian; Kang, Sung-Hae L; Carlin, Mary E; Michel, Donnice; Williams, Patricia; Cabrera-Meza, Gerardo; Brundage, Ellen K; Eifert, Anna L; Stankiewicz, Pawel; Cheung, Sau Wai; Lalani, Seema R

    2010-11-01

    Branchio-oto-renal syndrome is characterized by branchial defects, hearing loss, preauricular pits, and renal anomalies. Mutations in EYA1 are the most common cause of branchio-oto-renal and branchio-otic syndromes. Large chromosomal aberrations of 8q13, including complex rearrangements occur in about 20% of these individuals. However, submicroscopic deletions and the molecular characterization of genomic rearrangements involving the EYA1 gene have rarely been reported. Using the array-comparative genomic hybridization, we identified non-recurrent genomic deletions including the EYA1 gene in three patients with branchio-oto-renal syndrome, short stature, and developmental delay. One of these deletions was mediated by two human endogenous retroviral sequence blocks, analogous to the AZFa microdeletion on Yq11, responsible for male infertility. This report describes the expanded phenotype of individuals, resulting from contiguous gene deletion involving the EYA1 gene and provides a molecular description of the genomic rearrangements involving this gene in branchio-oto-renal syndrome. © 2010 Wiley-Liss, Inc.