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Sample records for muscle mass accretion

  1. Accretion disks around a mass with quadrupole

    CERN Document Server

    Abishev, Medeu; Quevedo, Hernando; Toktarbay, Saken

    2015-01-01

    We consider the stability properties of test particles moving along circular orbits around a mass with quadrupole. We show that the quadrupole modifies drastically the properties of an accretion disk made of such test particles.

  2. Accretion disks around a mass with quadrupole

    Science.gov (United States)

    Abishev, M.; Boshkayev, K.; Quevedo, H.; Toktarbay, S.

    We consider the stability properties of circular orbits of test particles moving around a mass with quadrupole. We show that the quadrupole modifies drastically the properties of an accretion disk made of such test particles.

  3. Leptin administration favors muscle mass accretion by decreasing FoxO3a and increasing PGC-1alpha in ob/ob mice.

    Directory of Open Access Journals (Sweden)

    Neira Sáinz

    Full Text Available Absence of leptin has been associated with reduced skeletal muscle mass in leptin-deficient ob/ob mice. The aim of our study was to examine the effect of leptin on the catabolic and anabolic pathways regulating muscle mass. Gastrocnemius, extensor digitorum longus and soleus muscle mass as well as fiber size were significantly lower in ob/ob mice compared to wild type littermates, being significantly increased by leptin administration (P<0.001. This effect was associated with an inactivation of the muscle atrophy-related transcription factor forkhead box class O3 (FoxO3a (P<0.05, and with a decrease in the protein expression levels of the E3 ubiquitin-ligases muscle atrophy F-box (MAFbx (P<0.05 and muscle RING finger 1 (MuRF1 (P<0.05. Moreover, leptin increased (P<0.01 protein expression levels of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha, a regulator of muscle fiber type, and decreased (P<0.05 myostatin protein, a negative regulator of muscle growth. Leptin administration also activated (P<0.01 the regulators of cell cycle progression proliferating cell nuclear antigen (PCNA and cyclin D1, and increased (P<0.01 myofibrillar protein troponin T. The present study provides evidence that leptin treatment may increase muscle mass of ob/ob mice by inhibiting myofibrillar protein degradation as well as enhancing muscle cell proliferation.

  4. Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice

    Science.gov (United States)

    Sáinz, Neira; Rodríguez, Amaia; Catalán, Victoria; Becerril, Sara; Ramírez, Beatriz; Gómez-Ambrosi, Javier; Frühbeck, Gema

    2009-01-01

    Absence of leptin has been associated with reduced skeletal muscle mass in leptin-deficient ob/ob mice. The aim of our study was to examine the effect of leptin on the catabolic and anabolic pathways regulating muscle mass. Gastrocnemius, extensor digitorum longus and soleus muscle mass as well as fiber size were significantly lower in ob/ob mice compared to wild type littermates, being significantly increased by leptin administration (P<0.001). This effect was associated with an inactivation of the muscle atrophy-related transcription factor forkhead box class O3 (FoxO3a) (P<0.05), and with a decrease in the protein expression levels of the E3 ubiquitin-ligases muscle atrophy F-box (MAFbx) (P<0.05) and muscle RING finger 1 (MuRF1) (P<0.05). Moreover, leptin increased (P<0.01) protein expression levels of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), a regulator of muscle fiber type, and decreased (P<0.05) myostatin protein, a negative regulator of muscle growth. Leptin administration also activated (P<0.01) the regulators of cell cycle progression proliferating cell nuclear antigen (PCNA) and cyclin D1, and increased (P<0.01) myofibrillar protein troponin T. The present study provides evidence that leptin treatment may increase muscle mass of ob/ob mice by inhibiting myofibrillar protein degradation as well as enhancing muscle cell proliferation. PMID:19730740

  5. Dynamical Masses of Accreting White Dwarfs

    Science.gov (United States)

    Pala, A. F.; Gänsckie, B. T.

    2017-03-01

    The mass retention efficiency is a key question in both the theoretical and observational study of accreting white dwarfs in interacting binaries, with important implications for their potential as progenitors for type Ia supernovae (SNe Ia). Canonical wisdom is that classical nova eruptions erode the white dwarf mass, and consequently, cataclysmic variables (CVs) have been excluded from the SN Ia progenitor discussion. However the average mass of white dwarfs in CVs is substantially higher (≃ 0.83 M⊙) than that of single white dwarfs (≃ 0.64 M ⊙), in stark contrast to expectations based on current classical nova models. This finding is based on a sample of ≃ 30 CV white dwarfs with accurate mass measurements, most of them in eclipsing systems. Given the fundamental importance of the mass evolution of accreting white dwarfs, it is necessary to enlarge this sample and to diversify the methods used for measuring masses. We have begun a systematic study of 27 CVs to almost double the number of CV white dwarfs with an accurate mass measurement. Using VLT/X-shooter phase-resolved observations, we can measure the white dwarf masses to a few percent, and will be able to answer the question whether accreting CV white dwarfs grow in mass.

  6. The mass accretion rate of galaxy clusters: a measurable quantity

    CERN Document Server

    De Boni, Cristiano; Diaferio, Antonaldo; Giocoli, Carlo; Baldi, Marco

    2015-01-01

    We explore the possibility of measuring the mass accretion rate of galaxy clusters by using dense galaxy redshift surveys of their outer regions. By approximating the accretion with the infall of a spherical shell, the mass accretion rate only depends on the mass profile of the cluster in a thin shell at radii larger than $R_{200}$. This approximation is rather crude in hierarchical clustering scenarios, where both smooth accretion and aggregation of smaller dark matter haloes contribute to the mass accretion of clusters. Nevertheless, in the redshift range $z=[0,1]$, our prescription returns an average mass accretion rate within $20 \\%$ of the average rate derived with the more realistic merger trees of dark matter haloes extracted from $N$-body simulations. The mass accretion rate of galaxy clusters has been the topic of numerous detailed numerical and theoretical investigations, but so far it has remained inaccessible to measurements in the real Universe. Our result suggests that measuring the mass accreti...

  7. Disk Accretion Onto High-Mass Planets

    CERN Document Server

    Lubow, S H; Artymowicz, P

    1999-01-01

    We analyze the nonlinear, two-dimensional response of a gaseous, viscous protoplanetary disk to the presence of a planet of one Jupiter mass (1 M_J) and greater that orbits a 1 solar mass star by using the ZEUS hydrodynamics code with high resolution near the planet's Roche lobe. The planet is assumed to be in a circular orbit about the central star and is not allowed to migrate. A gap is formed about the orbit of the planet, but there is a nonaxisymmetric flow through the gap and onto the planet. The gap partitions the disk into an inner (outer) disk that extends inside (outside) the planet's orbit. For a 1 M_J planet and typical disk parameters, the accretion through the gap onto the planet is highly efficient. For typical disk parameters, the mass doubling time scale is less than 10^5 years, considerably shorter than the disk lifetime. Following shocks near the L1 and L2 Lagrange points, disk material enters the Roche lobe in the form of two gas streams. Shocks occur within the Roche lobe as the gas stream...

  8. Accretion Disks around Young Low Mass Stars

    Directory of Open Access Journals (Sweden)

    Paola D´Alessio

    2001-01-01

    Full Text Available In the past decade, it has become clear that almost half of the low mass pre-main sequence stars are surrounded by disks, which are responsible for the observed infrared and optical-UV excess emission. The characterization of the structure of circumstellar disks is a crucial step towards understanding the early stellar evolution and planet formation. The thesis summarized here presents physical models of the detailed structure of accretion disks surrounding T Tauri stars. The disks are assumed to be in steady state, in vertical hydrostatic equilibrium, and with a turbulent viscosity described by the alpha-prescription. We consider different heating mechanisms: viscous dissipation, heating by cosmic rays and radioactive decay, irradiation by the central star or irradiation by an infalling envelope. The energy is transported in the vertical direction by radiation, convection and the turbulent flux. Give n the disk structure, we calculate its emission by integrating the radiative transfer equation for an arbitrary orientation of the disk relative to the line of sight. Spectral energy distributions (SEDs and images are compared with observations, and disk properties can be inferred or constrained.

  9. The mass accretion rate of galaxy clusters: a measurable quantity

    CERN Document Server

    De Boni, Cristiano

    2016-01-01

    We are interested in investigating the growth of structures at the nonlinear scales of galaxy clusters from an observational perspective: we explore the possibility of measuring the mass accretion rate of galaxy clusters from their mass profile beyond the virial radius. We derive the accretion rate from the mass of a spherical shell whose infall velocity is extracted from $N$-body simulations. In the redshift range $z=[0,2]$, our prescription returns an average mass accretion rate within $20-40 \\%$ of the average rate derived from the merger trees of dark matter haloes extracted from $N$-body simulations. Our result suggests that measuring the mean mass accretion rate of a sample of galaxy clusters is actually feasible, thus providing a new potential observational test of the cosmological and structure formation models.

  10. Accretion onto the First Stellar Mass Black Holes

    CERN Document Server

    Alvarez, Marcelo A; Abel, Tom

    2008-01-01

    The first stars in the universe, forming at redshifts z>15 in minihalos with masses of order 10^6 Msun, may leave behind black holes as their remnants. These objects could conceivably serve as "seeds" for much larger black holes observed at redshifts z~6. We study the growth of the remnant black holes through accretion including for the first time the emitted accretion radiation with adaptive mesh refinement cosmological radiation-hydrodynamical simulations. The effects of photo-ionization and heating dramatically affect the accretion flow from large scales, resulting in negligible mass growth of the black hole. We compare cases with the accretion luminosity included and neglected to show that the accretion radiation drastically changes the environment within 100 pc of the black hole, where gas temperatures are increased by an order of magnitude. The gas densities are reduced and further star formation in the same minihalo prevented for the two hundred million years of evolution we followed. These calculation...

  11. Jets at lowest mass accretion rates

    NARCIS (Netherlands)

    Maitra, D.; Cantrell, A.; Markoff, S.; Falcke, H.; Miller, J.; Bailyn, C.

    2011-01-01

    We present results of recent observations and theoretical modeling of data from black holes accreting at very low luminosities (L/LEdd ≲ 10−8). We discuss our newly developed time-dependent model for episodic ejection of relativistic plasma within a jet framework, and a successful application of thi

  12. Millisecond phenomena in mass accreting neutron stars

    NARCIS (Netherlands)

    van der Klis, M.; Cohen, L.

    2007-01-01

    The past twelve years have seen the discovery, with NASA's Rossi X-ray Timing Explorer (RXTE), of several long-predicted phenomena associated with the accretion of matter onto a neutron star in a binary (double) star system. These phenomena are observed in the strong X-ray emission produced by these

  13. A single session of neuromuscular electrical stimulation does not augment postprandial muscle protein accretion.

    Science.gov (United States)

    Dirks, Marlou L; Wall, Benjamin T; Kramer, Irene Fleur; Zorenc, Antoine H; Goessens, Joy P B; Gijsen, Annemie P; van Loon, Luc J C

    2016-07-01

    The loss of muscle mass and strength that occurs with aging, termed sarcopenia, has been (at least partly) attributed to an impaired muscle protein synthetic response to food intake. Previously, we showed that neuromuscular electrical stimulation (NMES) can stimulate fasting muscle protein synthesis rates and prevent muscle atrophy during disuse. We hypothesized that NMES prior to protein ingestion would increase postprandial muscle protein accretion. Eighteen healthy elderly (69 ± 1 yr) males participated in this study. After a 70-min unilateral NMES protocol was performed, subjects ingested 20 g of intrinsically l-[1-(13)C]phenylalanine-labeled casein. Plasma samples and muscle biopsies were collected to assess postprandial mixed muscle and myofibrillar protein accretion as well as associated myocellular signaling during a 4-h postprandial period in both the control (CON) and stimulated (NMES) leg. Protein ingestion resulted in rapid increases in both plasma phenylalanine concentrations and l-[1-(13)C]phenylalanine enrichments, which remained elevated during the entire 4-h postprandial period (P 0.05). In agreement, no differences were observed in the postprandial rise in myofibrillar protein bound l-[1-(13)C]phenylalanine enrichments between the CON and NMES legs (0.0115 ± 0.0014 vs. 0.0133 ± 0.0013 MPE, respectively, P > 0.05). Significant increases in mTOR and P70S6K phosphorylation status were observed in the NMES-stimulated leg only (P < 0.05). We conclude that a single session of NMES prior to food intake does not augment postprandial muscle protein accretion in healthy older men. Copyright © 2016 the American Physiological Society.

  14. Role of protein and amino acids in promoting lean mass accretion with resistance exercise and attenuating lean mass loss during energy deficit in humans.

    Science.gov (United States)

    Churchward-Venne, Tyler A; Murphy, Caoileann H; Longland, Thomas M; Phillips, Stuart M

    2013-08-01

    Amino acids are major nutrient regulators of muscle protein turnover. After protein ingestion, hyperaminoacidemia stimulates increased rates of skeletal muscle protein synthesis, suppresses muscle protein breakdown, and promotes net muscle protein accretion for several hours. These acute observations form the basis for strategized protein intake to promote lean mass accretion, or prevent lean mass loss over the long term. However, factors such as protein dose, protein source, and timing of intake are important in mediating the anabolic effects of amino acids on skeletal muscle and must be considered within the context of evaluating the reported efficacy of long-term studies investigating protein supplementation as part of a dietary strategy to promote lean mass accretion and/or prevent lean mass loss. Current research suggests that dietary protein supplementation can augment resistance exercise-mediated gains in skeletal muscle mass and strength and can preserve skeletal muscle mass during periods of diet-induced energy restriction. Perhaps less appreciated, protein supplementation can augment resistance training-mediated gains in skeletal muscle mass even in individuals habitually consuming 'adequate' (i.e., >0.8 g kg⁻¹ day⁻¹) protein. Additionally, overfeeding energy with moderate to high-protein intake (15-25 % protein or 1.8-3.0 g kg⁻¹ day⁻¹) is associated with lean, but not fat mass accretion, when compared to overfeeding energy with low protein intake (5 % protein or ~0.68 g kg⁻¹ day⁻¹). Amino acids represent primary nutrient regulators of skeletal muscle anabolism, capable of enhancing lean mass accretion with resistance exercise and attenuating the loss of lean mass during periods of energy deficit, although factors such as protein dose, protein source, and timing of intake are likely important in mediating these effects.

  15. The evolution of the core mass function by gas accretion

    CERN Document Server

    Dib, Sami

    2012-01-01

    We show how the mass function of dense cores (CMF) which results from the gravoturbulent fragmentation of a molecular cloud evolves in time under the effect of gas accretion. Accretion onto the cores leads to the formation of larger numbers of massive cores and to a flattening of the CMF. This effect should be visible in the CMF of star forming regions that are massive enough to contain high mass cores and when comparing the CMF of cores in and off dense filaments which have different environmental gas densities.

  16. On the Maximum Mass of Accreting Primordial Supermassive Stars

    Science.gov (United States)

    Woods, T. E.; Heger, Alexander; Whalen, Daniel J.; Haemmerlé, Lionel; Klessen, Ralf S.

    2017-06-01

    Supermassive primordial stars are suspected to be the progenitors of the most massive quasars at z ˜ 6. Previous studies of such stars were either unable to resolve hydrodynamical timescales or considered stars in isolation, not in the extreme accretion flows in which they actually form. Therefore, they could not self-consistently predict their final masses at collapse, or those of the resulting supermassive black hole seeds, but rather invoked comparison to simple polytropic models. Here, we systematically examine the birth, evolution, and collapse of accreting, non-rotating supermassive stars under accretion rates of 0.01-10 M ⊙ yr-1 using the stellar evolution code Kepler. Our approach includes post-Newtonian corrections to the stellar structure and an adaptive nuclear network and can transition to following the hydrodynamic evolution of supermassive stars after they encounter the general relativistic instability. We find that this instability triggers the collapse of the star at masses of 150,000-330,000 M ⊙ for accretion rates of 0.1-10 M ⊙ yr-1, and that the final mass of the star scales roughly logarithmically with the rate. The structure of the star, and thus its stability against collapse, is sensitive to the treatment of convection and the heat content of the outer accreted envelope. Comparison with other codes suggests differences here may lead to small deviations in the evolutionary state of the star as a function of time, that worsen with accretion rate. Since the general relativistic instability leads to the immediate death of these stars, our models place an upper limit on the masses of the first quasars at birth.

  17. Imprints of mass accretion on properties of galaxy clusters

    CERN Document Server

    Faltenbacher, A; Gottlöber, S; Yepes, G; Hoffman, Y; Faltenbacher, Andreas; Allgood, Brandon; Gottloeber, Stefan; Yepes, Gustavo; Hoffman, Yehuda

    2005-01-01

    We use a large scale N-body simulation of the flat LCDM universe, including adiabatic gas dynamics (GADGET), to investigate the impact of mass accretion modes of galaxy clusters on the vector quantities, orientation and angular momentum. Our cluster sample comprises the 3000 most massive friends-of-friends halos found in the 500 Mpc/h simulation box. We use the mass ratios of the two most massive progenitors at z=0.5 m_2/m_1 (m_1 < m_2) to construct two accretion mode sub-samples, a recent major merger sample and a steady accretion mode sample. We find that the mass of current clusters in the merger sample is on average ~43% larger than the mass of the two progenitors (m_1 + m_2), whereas in the steady accretion mode sample a smaller increase of ~25% is found. We show that the separation vector connecting the two most massive progenitor halos at z=0.5 is strongly correlated with the orientation of the current cluster. We also find that the current angular momentum in the recent major merger sample tends to...

  18. Chemical tracers of episodic accretion in low-mass protostars

    CERN Document Server

    Visser, Ruud; Jorgensen, Jes K

    2015-01-01

    Aims: Accretion rates in low-mass protostars can be highly variable in time. Each accretion burst is accompanied by a temporary increase in luminosity, heating up the circumstellar envelope and altering the chemical composition of the gas and dust. This paper aims to study such chemical effects and discusses the feasibility of using molecular spectroscopy as a tracer of episodic accretion rates and timescales. Methods: We simulate a strong accretion burst in a diverse sample of 25 spherical envelope models by increasing the luminosity to 100 times the observed value. Using a comprehensive gas-grain network, we follow the chemical evolution during the burst and for up to 10^5 yr after the system returns to quiescence. The resulting abundance profiles are fed into a line radiative transfer code to simulate rotational spectra of C18O, HCO+, H13CO+, and N2H+ at a series of time steps. We compare these spectra to observations taken from the literature and to previously unpublished data of HCO+ and N2H+ 6-5 from th...

  19. Nutritional interventions to preserve skeletal muscle mass

    NARCIS (Netherlands)

    Backx, Evelien M.P.

    2016-01-01

    Muscle mass is the main predictor for muscle strength and physical function. The amount of muscle mass can decline rapidly during periods of reduced physical activity or during periods of energy intake restriction. For athletes, it is important to maintain muscle mass, since the loss of muscle is

  20. Nutritional interventions to preserve skeletal muscle mass

    NARCIS (Netherlands)

    Backx, Evelien M.P.

    2016-01-01

    Muscle mass is the main predictor for muscle strength and physical function. The amount of muscle mass can decline rapidly during periods of reduced physical activity or during periods of energy intake restriction. For athletes, it is important to maintain muscle mass, since the loss of muscle is as

  1. Limits on luminosity and mass accretion rate of a radiation pressure dominated accretion disc

    CERN Document Server

    Cao, Xinwu

    2015-01-01

    There is a maximum for the gravity of a black hole in the vertical direction in the accretion disc. Outflows may probably be driven from the disc if the radiation flux of the disc is greater than a critical value corresponding to the maximal vertical gravity. We find that outflows are driven by the radiation force from the disc if the accretion rate is greater than the Eddington rate. The radiation of the disc is therefore limited by such outflows. The disc luminosity, L=L_Edd\\propto ln mdot, at large-mdot cases. The Eddington ratio of the disc is ~3 for mdot~100, which is significantly lower than that of a conventional slim disc without outflows. This implies that the emission from some ultra-luminous X-ray sources with highly super Eddington luminosity should be Doppler beamed, or intermediate mass black holes are in these sources instead of stellar mass black holes. The spectra of the discs with outflows are saturated in the high frequency end provided mdot>2. We suggest that the saturated emission can be ...

  2. Black hole mass, jet power and accretion in AGN

    CERN Document Server

    Chen, Yong-Yun; Xiong, Dingrong; Yu, Xiaoling

    2015-01-01

    We study the relation between accretion, black hole mass and jet power in AGN, by using a large group of blazars detected by the Fermi Large Area Telescope and radio galaxies. Our main results are as follows. (i) The jet power of FSRQs and FRII-HEG depends on the black hole mass, which suggests that the FSRQs and FRII-HEG are in Radiation-Pressure Dominated regime. The jet power of BL Lacs and FRI-LEG depends on the accretion, which suggests that the BL Lacs and FRI-LEG are in the Gas-Pressure Dominated regime. (ii) We find that most of FSRQs and BL Lacs have $\\rm{P_{jet}>L_{BZ}^{max}}$, which suggests that the Blandford-Znajek mechanism is insufficient to explain the jet power of these objects. (iii) The FSRQs are roughly separated from BL Lacs by the Ledlow-Owen's dividing line in the $\\rm{\\log P_{jet}-\\log M}$ plane, which supports the unified scheme of AGN. (iv) The FSRQs and BL Lacs have a clear division at $\\rm{L_{bol}/L_{Edd}\\sim0.01}$, and the distribution of Eddington ratios of BL Lacs and FSRQs exhi...

  3. Constraining protoplanetary disc evolution using accretion rate and disc mass measurements: the usefulness of the dimensionless accretion parameter

    Science.gov (United States)

    Rosotti, Giovanni P.; Clarke, Cathie J.; Manara, Carlo F.; Facchini, Stefano

    2017-06-01

    We explore how measurements of protoplanetary disc masses and accretion rates provided by surveys of star-forming regions can be analysed via the dimensionless accretion parameter, which we define as the product of the accretion rate and stellar age divided by the disc mass. By extending and generalizing the study of Jones et al., we demonstrate that this parameter should be less than or of order unity for a wide range of evolutionary scenarios, rising above unity only during the final stages of outside-in clearing by external photoevaporation. We use this result to assess the reliability of disc mass estimates derived from CO isotopologues and sub-mm continuum emission by examining the distribution of accretion efficiencies in regions that are not subject to external photoevaporation. We find that while dust-based mass estimates produce results compatible with theoretical expectations assuming a canonical dust-to-gas ratio, the systematically lower CO-based estimates yield accretion efficiencies significantly above unity in contrast with the theory. This finding provides additional evidence that CO-based disc masses are an underestimate, in line with arguments that have been made on the basis of chemical modelling of relatively small samples. On the other hand, we demonstrate that dust-based mass estimates are sufficiently accurate to reveal distinctly higher accretion efficiencies in the Trapezium cluster, where this result is expected, given the evident importance of external photoevaporation. We therefore propose the dimensionless accretion parameter as a new diagnostic of external photoevaporation in other star-forming regions.

  4. Smearing of mass accretion rate variation by viscous processes in accretion disks in compact binary systems

    CERN Document Server

    Ghosh, Arindam

    2016-01-01

    Variation of mass supply rate from the companion can be smeared out by viscous processes inside an accretion disk. By the time the flow reaches the inner edge, the variation in X-rays needs not reflect the true variation of the rate at the outer edge. However, if the viscosity fluctuates around a mean value, one would expect the viscous time scale also to spread around a mean value. In HMXBs, the size of the viscous Keplerian disk is smaller & thus such a spread could be lower as compared to the LMXBs. If there is an increasing or decreasing trend in viscosity, the interval between enhanced emission would be modified systematically. In the absence of a full knowledge about the variation of mass supply rates at the outer edge, we study ideal circumstances where modulation must take place exactly in orbital time scales when there is an ellipticity in the orbit. We study a few compact binaries using long term RXTE/ASM(1.5-12 keV) & Swift/BAT(15-50keV) data to look for such effects & to infer what the...

  5. Accretion in supergiant High Mass X-ray Binaries

    Directory of Open Access Journals (Sweden)

    Manousakis Antonios

    2014-01-01

    Full Text Available Supergiant High Mass X-ray Binary systems (sgHMXBs consist of a massive, late type, star and a neutron star. The massive stars exhibits strong, radiatively driven, stellar winds. Wind accretion onto compact object triggers X-ray emission, which alters the stellar wind significantly. Hydrodynamic simulation has been used to study the neutron star - stellar wind interaction it two sgHMXBs: i A heavily obscured sgHMXB (IGR J17252–3616 discovered by INTEGRAL. To account for observable quantities (i.e., absorbing column density we have to assume a very slow wind terminal velocity of about 500 km/s and a rather massive neutron star. If confirmed in other obscured systems, this could provide a completely new stellar wind diagnostics. ii A classical sgHMXB (Vela X-1 has been studied in depth to understand the origin of the off-states observed in this system. Among many models used to account for this observed behavior (clumpy wind, gating mechanism we propose that self-organized criticality of the accretion stream is the likely reason for the observed behavior. In conclusion, the neutron star, in these two examples, acts very effciently as a probe to study stellar winds.

  6. Mass loss from advective accretion disc around rotating black holes

    CERN Document Server

    Aktar, Ramiz; Nandi, Anuj

    2015-01-01

    We examine the properties of the outflowing matter from an advective accretion disc around a spinning black hole. During accretion, rotating matter experiences centrifugal pressure supported shock transition that effectively produces a virtual barrier around the black hole in the form of post-shock corona (hereafter, PSC). Due to shock compression, PSC becomes hot and dense that eventually deflects a part of the inflowing matter as bipolar outflows because of the presence of extra thermal gradient force. In our approach, we study the outflow properties in terms of the inflow parameters, namely specific energy (${\\mathcal E}$) and specific angular momentum ($\\lambda$) considering the realistic outflow geometry around the rotating black holes. We find that spin of the black hole ($a_k$) plays an important role in deciding the outflow rate $R_{\\dot m}$ (ratio of mass flux of outflow and inflow), in particular, $R_{\\dot m}$ is directly correlated with $a_k$ for the same set of inflow parameters. It is found that ...

  7. Damping of prominence longitudinal oscillations due to mass accretion

    CERN Document Server

    Ruderman, Michael

    2016-01-01

    We study the damping of longitudinal oscillations of a prominence thread caused by the mass accretion. In this model we considered a thin curved magnetic tube filled with the plasma. The parts of the tube at the two sides of the thread are filled with hot rarefied plasma. We assume that there are flows of rarefied plasma toward the thread caused by the plasma evaporation at the magnetic tube footpoints. Our main assumption is that the hot plasma is instantaneously accommodated by the thread when it arrives at the thread, and its temperature and density become equal to those of the thread. Then we derive the system of ordinary differential equations describing the thread dynamics. We consider linear and nonlinear oscillation. The nonlinearity reduces the damping time, however this reduction is small. The damping time is inversely proportional to the accretion rate. We also obtain that the oscillation periods decrease with time. However even for the largest initial oscillation amplitude considered in our articl...

  8. Smearing of mass accretion rate variation by viscous processes in accretion disks in compact binary systems

    Science.gov (United States)

    Ghosh, A.; Chakrabarti, Sandip K.

    2016-09-01

    Variation of mass supply rate from the companion can be smeared out by viscous processes inside an accretion disk. Hence, by the time the flow reaches the inner edge, the variation in X-rays need not reflect the true variation of the mass supply rate at the outer edge. However, if the viscosity fluctuates around a mean value, one would expect the viscous time scale t_{{visc}} also to spread around a mean value. In high mass X-ray binaries, which are thought to be primarily wind-fed, the size of the viscous Keplerian disk is smaller and thus such a spread could be lower as compared to the low mass X-ray binaries which are primarily fed by Roche lobe overflow. If there is an increasing or decreasing trend in viscosity, the interval between enhanced emission would be modified systematically. In the absence of a detailed knowledge about the variation of mass supply rates at the outer edge, we study ideal circumstances where modulation must take place exactly in orbital time scales, such as when there is an ellipticity in the orbit. We study a few compact binaries using long term All Sky monitor (ASM) data (1.5-12 keV) of Rossi X-ray Timing Explorer (RXTE) and all sky survey data (15-50 keV) of Swift satellites by different methods to look for such smearing effects and to infer what these results can tell us about the viscous processes inside the respective disks. We employ three different methods to seek imprints of periodicity on the X-ray variation and found that in all the cases, the location of the peak in the power density spectra is consistent with the orbital frequencies. Interestingly, in high mass X-ray binaries the peaks are sharp with high rms values, consistent with a small Keplerian disk in a wind fed system. However, in low mass X-ray binaries with larger Keplerian disk component, the peaks are spreaded out with much lower rms values. X-ray reflections, or superhump phenomena which may also cause such X-ray modulations would not be affected by the size of

  9. Neutrino pair annihilation near accreting, stellar-mass black holes

    CERN Document Server

    Birkl, R; Janka, H T; Müller, E

    2006-01-01

    We investigate the energy-momentum deposition due to neutrino-antineutrino annihilation in the vicinity of axisymmetric, accreting black holes (BHs) by numerically ray-tracing neutrino trajectories in a Kerr space-time. Hyperaccreting stellar-mass BHs are widely considered as energy sources that can drive ultrarelativistic outflows with the potential to produce gamma-ray bursts. In contrast to earlier works, we provide an extensive and detailed parameter study of the influence of general relativistic (GR) effects and of different neutrinosphere geometries. These include idealized thin disks, tori, and spheres, or are constructed as non-selfgravitating equilibrium matter distributions for varied BH rotation. Considering isothermal neutrinospheres with the same temperature and surface area, we confirm previous results that compared to Newtonian calculations, GR effects increase the annihilation rate measured by an observer at infinity by a factor of 2 when the neutrinosphere is a disk. However, in case of a tor...

  10. X-shooter study of accretion in Chamaeleon I. II. A steeper increase of accretion with stellar mass for very low-mass stars?

    Science.gov (United States)

    Manara, C. F.; Testi, L.; Herczeg, G. J.; Pascucci, I.; Alcalá, J. M.; Natta, A.; Antoniucci, S.; Fedele, D.; Mulders, G. D.; Henning, T.; Mohanty, S.; Prusti, T.; Rigliaco, E.

    2017-08-01

    The dependence of the mass accretion rate on the stellar properties is a key constraint for star formation and disk evolution studies. Here we present a study of a sample of stars in the Chamaeleon I star-forming region carried out using spectra taken with the ESO VLT/X-shooter spectrograph. The sample is nearly complete down to stellar masses (M⋆) 0.1 M⊙ for the young stars still harboring a disk in this region. We derive the stellar and accretion parameters using a self-consistent method to fit the broadband flux-calibrated medium resolution spectrum. The correlation between accretion luminosity to stellar luminosity, and of mass accretion rate to stellar mass in the logarithmic plane yields slopes of 1.9 ± 0.1 and 2.3 ± 0.3, respectively. These slopes and the accretion rates are consistent with previous results in various star-forming regions and with different theoretical frameworks. However, we find that a broken power-law fit, with a steeper slope for stellar luminosity lower than 0.45 L⊙ and for stellar masses lower than 0.3 M⊙ is slightly preferred according to different statistical tests, but the single power-law model is not excluded. The steeper relation for lower mass stars can be interpreted as a faster evolution in the past for accretion in disks around these objects, or as different accretion regimes in different stellar mass ranges. Finally, we find two regions on the mass accretion versus stellar mass plane that are empty of objects: one region at high mass accretion rates and low stellar masses, which is related to the steeper dependence of the two parameters we derived. The second region is located just above the observational limits imposed by chromospheric emission, at M⋆ 0.3 - 0.4 M⊙. These are typical masses where photoevaporation is known to be effective. The mass accretion rates of this region are 10-10M⊙/yr, which is compatible with the value expected for photoevaporation to rapidly dissipate the inner disk. This work is

  11. Evidence for a correlation between mass accretion rates onto young stars and the mass of their protoplanetary disks

    CERN Document Server

    Manara, C F; Testi, L; Natta, A; Alcalá, J M; Williams, J P; Ansdell, M; Miotello, A; van der Marel, N; Tazzari, M; Carpenter, J; Guidi, G; Mathews, G S; Oliveira, I; Prusti, T; van Dishoeck, E F

    2016-01-01

    A relation between the mass accretion rate onto the central young star and the mass of the surrounding protoplanetary disk has long been theoretically predicted and observationally sought. For the first time, we have accurately and homogeneously determined the photospheric parameters, the mass accretion rate, and the disk mass for an essentially complete sample of young stars with disks in the Lupus clouds. Our work combines the results of surveys conducted with VLT/X-Shooter and ALMA. With this dataset we are able to test a basic prediction of viscous accretion theory, the existence of a linear relation between the mass accretion rate onto the central star and the total disk mass. We find a correlation between the mass accretion rate and the disk dust mass, with a ratio that is roughly consistent with the expected viscous timescale when assuming an ISM gas-to-dust ratio. This confirms that mass accretion rates are related to the properties of the outer disk. We find no correlation between mass accretion rate...

  12. A Theoretical Model of Non-conservative Mass Transfer with Non-uniform Mass Accretion Rate in Close Binary Stars

    CERN Document Server

    Gharami, Prabir; Rahaman, Farook

    2014-01-01

    Mass transfer in close binaries is often non-conservative and the modeling of this kind of mass transfer is mathematically challenging as in this case due to the loss of mass as well as angular momentum the governing system gets complicated and uncertain. In the present work a new mathematical model has been prescribed for the non-conservative mass transfer in a close binary system taking in to account the gradually decreasing profile of the mass accretion rate by the accreting star with respect to time as well as with respect to the increase in mass of the accreting star. The process of mass transfer is understood to occur up to a critical mass limit of the accreting star beyond which this process may cease to work.

  13. Mass accretion flows in the high-mass star forming complex NGC 6334

    Science.gov (United States)

    Sánchez-Monge, Á.; Schilke, P.; Zernickel, A.; Schmiedeke, A.; Möller, Th.; Qin, S.-L.

    2016-05-01

    The formation of high-mass stars is one of the major topics of astrophysical research, in particular the process of accretion from large-scale clouds down to small-scale cores. We have selected the nearby, filamentary, high-mass star forming complex NGC 6334 to study the gas velocity at different scales and probe the infall rates onto the protostellar cores embedded in the NGC 6334-I and I(N) clusters. This study makes use of single-dish and interferometric submillimeter observations, complemented with 3D numerical non-LTE radiative transfer modeling. We measure a mass accretion rate of 10-5 M⊙ yr-1 throughout the filament increasing up to 10-3 M⊙ yr-1 towards the densest regions where high-mass stars are forming. At smaller scales, our 3D model is consistent with accretion rates of 10-3 M⊙ yr-1 towards the clusters, and 10-4 M⊙ yr-1 onto the protostars.

  14. Black-hole masses, accretion rates and hot- and cold-mode accretion in radio galaxies at z~1

    CERN Document Server

    Fernandes, Cristina A C; Martínez-Sansigre, Alejo; Rawlings, Steve; Afonso, José; Hardcastle, Martin J; Lacy, Mark; Stevens, Jason A; Vardoulaki, Eleni

    2014-01-01

    Understanding the evolution of accretion activity is fundamental to our understanding of how galaxies form and evolve over the history of the Universe. We analyse a complete sample of 27 radio galaxies which includes both high-excitation (HEGs) and low excitation galaxies (LEGs), spanning a narrow redshift range of 0.9 < z < 1.1 and covering a factor of ~1000 in radio luminosity. Using data from the Spitzer Space Telescope combined with ground-based optical and near-infrared imaging, we show that the host galaxies have masses in the range of 10.7 < log (M /M_sun) < 12.0 with HEGs and LEGs exhibiting no difference in their mass distributions. We also find that HEGs accrete at significantly higher rates than LEGs, with the HEG/LEG division lying at an Eddington ratio of ~0.04, which is in excellent agreement with theoretical predictions of where the accretion rate becomes radiatively inefficient, thus supporting the idea of HEGs and LEGs being powered by different modes of accretion. Our study also ...

  15. Accretion disc atmospheres and winds in low-mass X-ray binaries

    CERN Document Server

    Trigo, M Díaz

    2015-01-01

    In the last decade, X-ray spectroscopy has enabled a wealth of discoveries of photoionised absorbers in X-ray binaries. Studies of such accretion disc atmospheres and winds are of fundamental importance to understand accretion processes and possible feedback mechanisms to the environment. In this work, we review the current observational state and theoretical understanding of accretion disc atmospheres and winds in low-mass X-ray binaries, focusing on the wind launching mechanisms and on the dependence on accretion state. We conclude with issues that deserve particular attention.

  16. The fundamental plane of accretion onto black holes with dynamical masses

    NARCIS (Netherlands)

    K. Gültekin; E.M. Cackett; J.M. Miller; T. Di Matteo; S. Markoff; D.O. Richstone

    2009-01-01

    Black hole accretion and jet production are areas of intensive study in astrophysics. Recent work has found a relation between radio luminosity, X-ray luminosity, and black hole mass. With the assumption that radio and X-ray luminosities are suitable proxies for jet power and accretion power, respec

  17. Probing BH mass and accretion through X-ray variability in the CDFS

    CERN Document Server

    Allevato, V; Paolillo, M; Papadakis, I; Ranalli, P; Comastri, A; Iwasawa, K

    2009-01-01

    Recent work on nearby AGNs has shown that X-ray variability is correlated with the mass and accretion rate onto the central SMBH. Here we present the application of the variability-luminosity relation to high redshift AGNs in the CDFS, making use of XMM-Newton observations. We use Montecarlo simulations in order to properly account for bias and uncertainties introduced by the sparse sampling and the very low statistics. Our preliminary results indicate that BH masses span over the range from 10^5 to 10^9 solar mass while accretion rates range from 10^-3 up to values greater than 1, in unit of Eddington accretion rate.

  18. The mass profile and accretion history of cold dark matter haloes

    Science.gov (United States)

    Ludlow, Aaron D.; Navarro, Julio F.; Boylan-Kolchin, Michael; Bett, Philip E.; Angulo, Raúl E.; Li, Ming; White, Simon D. M.; Frenk, Carlos; Springel, Volker

    2013-06-01

    We use the Millennium Simulation series to investigate the relation between the accretion history and mass profile of cold dark matter (CDM) haloes. We find that the mean inner density within the scale radius, r-2 (where the halo density profile has isothermal slope), is directly proportional to the critical density of the Universe at the time when the virial mass of the main progenitor equals the mass enclosed within r-2. Scaled to these characteristic values of mass and density, the average mass accretion history, expressed in terms of the critical density of the Universe, M(ρcrit(z)), resembles that of the enclosed density profile, M(), at z = 0. Both follow closely the Navarro, Frenk & White (NFW) profile, which suggests that the similarity of halo mass profiles originates from the mass-independence of halo accretion histories. Support for this interpretation is provided by outlier haloes whose accretion histories deviate from the NFW shape; their mass profiles show correlated deviations from NFW and are better approximated by Einasto profiles. Fitting both M() and M(ρcrit) with either NFW or Einasto profiles yield concentration and shape parameters that are correlated, confirming and extending earlier work that has linked the concentration of a halo with its accretion history. These correlations also confirm that halo structure is insensitive to initial conditions: only haloes whose accretion histories differ greatly from the NFW shape show notable deviations from NFW in their mass profiles. As a result, the NFW profile provides acceptable fits to hot dark matter haloes, which do not form hierarchically, and for fluctuation power spectra other than CDM. Our findings, however, predict a subtle but systematic dependence of mass profile shape on accretion history which, if confirmed, would provide strong support for the link between accretion history and halo structure we propose here.

  19. Accretion of Jupiter-mass planets in the limit of vanishing viscosity

    Energy Technology Data Exchange (ETDEWEB)

    Szulágyi, J.; Morbidelli, A.; Crida, A. [University of Nice-Sophia Antipolis, CNRS, Observatoire de la Côte d' Azur, Laboratoire Lagrange, F-06304, Nice (France); Masset, F., E-mail: jszulagyi@oca.eu [Instituto de Ciencias Físicas, Universidad Nacional Autónoma de México, P.O. Box 48-3, 62251 Cuernavaca, Morelos (Mexico)

    2014-02-20

    In the core-accretion model, the nominal runaway gas-accretion phase brings most planets to multiple Jupiter masses. However, known giant planets are predominantly Jupiter mass bodies. Obtaining longer timescales for gas accretion may require using realistic equations of states, or accounting for the dynamics of the circumplanetary disk (CPD) in the low-viscosity regime, or both. Here we explore the second way by using global, three-dimensional isothermal hydrodynamical simulations with eight levels of nested grids around the planet. In our simulations, the vertical inflow from the circumstellar disk (CSD) to the CPD determines the shape of the CPD and its accretion rate. Even without a prescribed viscosity, Jupiter's mass-doubling time is ∼10{sup 4} yr, assuming the planet at 5.2 AU and a Minimum Mass Solar Nebula. However, we show that this high accretion rate is due to resolution-dependent numerical viscosity. Furthermore, we consider the scenario of a layered CSD, viscous only in its surface layer, and an inviscid CPD. We identify two planet-accretion mechanisms that are independent of the viscosity in the CPD: (1) the polar inflow—defined as a part of the vertical inflow with a centrifugal radius smaller than two Jupiter radii and (2) the torque exerted by the star on the CPD. In the limit of zero effective viscosity, these two mechanisms would produce an accretion rate 40 times smaller than in the simulation.

  20. Mass accretion rates in self-regulated disks of T Tauri stars

    CERN Document Server

    Vorobyov, E I

    2008-01-01

    We have studied numerically the evolution of protostellar disks around intermediate and upper mass T Tauri stars (0.25 M_sun < M_st < 3.0 M_sun) that have formed self-consistently from the collapse of molecular cloud cores. In the T Tauri phase, disks settle into a self-regulated state, with low-amplitude nonaxisymmetric density perturbations persisting for at least several million years. Our main finding is that the global effect of gravitational torques due to these perturbations is to produce disk accretion rates that are of the correct magnitude to explain observed accretion onto T Tauri stars. Our models yield a correlation between accretion rate M_dot and stellar mass M_st that has a best fit M_dot \\propto M_st^{1.7}, in good agreement with recent observations. We also predict a near-linear correlation between the disk accretion rate and the disk mass.

  1. Cold-Mode Accretion: Driving the Fundamental Mass-Metallicity Relation at z~2

    CERN Document Server

    Kacprzak, Glenn G; Glazebrook, Karl; Tran, Kim-Vy H; Yuan, Tiantian; Nanayakkara, Themiya; Allen, Rebecca J; Alcorn, Leo; Cowley, Michael; Labbe, Ivo; Spitler, Lee; Straatman, Caroline; Tomczak, Adam

    2016-01-01

    We investigate the star formation rate (SFR) dependence on the stellar mass and gas-phase metallicity relation at z=2 with MOSFIRE/Keck as part of the ZFIRE survey. We have identified 117 galaxies (1.98 10$~M$_{\\odot}$yr$^{-1}$) SFRs. At fixed mass, low star-forming galaxies tend to have higher metallicity than high star-forming galaxies. Using a few basic assumptions, we further show that the gas masses and metallicities required to produce the fundamental mass--metallicity relation, and its intrinsic scatter, are consistent with cold-mode accretion predictions obtained from the OWLS hydrodynamical simulations. Our results from both simulations and observations are suggestive that cold-mode accretion is responsible for the fundamental mass-metallicity relation at $z=2$ and demonstrates the direct relationship between cosmological accretion and the fundamental properties of galaxies.

  2. Inner edge of accretion disks in low mass X-ray binaries

    Institute of Scientific and Technical Information of China (English)

    李向东; 汪珍如

    1995-01-01

    The magnitude of the inner edge of accretion disks in low mass X-ray binaries is controversial in theoretical considerations and observations. Using the inner boundary conditions of accretion disks the inner disk radius has been calculated by taking into account the effect of feedback radiation and the deviation of disk rotation from Keplerian. Results have been applied to the observations and possible interpretations have been proposed for the X-ray spectra and quasiperiodic oscillations.

  3. Formation of Massive Primordial Stars: Intermittent UV Feedback with Episodic Mass Accretion

    Science.gov (United States)

    Hosokawa, Takashi; Hirano, Shingo; Kuiper, Rolf; Yorke, Harold W.; Omukai, Kazuyuki; Yoshida, Naoki

    2016-06-01

    We present coupled stellar evolution (SE) and 3D radiation-hydrodynamic (RHD) simulations of the evolution of primordial protostars, their immediate environment, and the dynamic accretion history under the influence of stellar ionizing and dissociating UV feedback. Our coupled SE RHD calculations result in a wide diversity of final stellar masses covering 10 {M}⊙ ≲ M * ≲ 103 {M}⊙ . The formation of very massive (≳250 {M}⊙ ) stars is possible under weak UV feedback, whereas ordinary massive (a few ×10 {M}⊙ ) stars form when UV feedback can efficiently halt the accretion. This may explain the peculiar abundance pattern of a Galactic metal-poor star recently reported by Aoki et al., possibly the observational signature of very massive precursor primordial stars. Weak UV feedback occurs in cases of variable accretion, in particular when repeated short accretion bursts temporarily exceed 0.01 {M}⊙ {{{yr}}}-1, causing the protostar to inflate. In the bloated state, the protostar has low surface temperature and UV feedback is suppressed until the star eventually contracts, on a thermal adjustment timescale, to create an H ii region. If the delay time between successive accretion bursts is sufficiently short, the protostar remains bloated for extended periods, initiating at most only short periods of UV feedback. Disk fragmentation does not necessarily reduce the final stellar mass. Quite the contrary, we find that disk fragmentation enhances episodic accretion as many fragments migrate inward and are accreted onto the star, thus allowing continued stellar mass growth under conditions of intermittent UV feedback. This trend becomes more prominent as we improve the resolution of our simulations. We argue that simulations with significantly higher resolution than reported previously are needed to derive accurate gas mass accretion rates onto primordial protostars.

  4. Unstable mass-outflows in geometrically thick accretion flows around black holes

    CERN Document Server

    Okuda, Toru

    2015-01-01

    Accretion flows around black holes generally result in mass-outflows that exhibit irregular behavior quite often. Using 2D time-dependent hydrodynamical calculations, we show that the mass-outflow is unstable in the cases of thick accretion flows such as the low angular momentum accretion flow and the advection-dominated accretion flow. For the low angular momentum flow, the inward accreting matter on the equatorial plane interacts with the outflowing gas along the rotational axis and the centrifugally supported oblique shock is formed at the interface of both the flows, when the viscosity parameter $\\alpha$ is as small as $\\alpha \\le 10^{-3}$. The hot and rarefied blobs, which result in the eruptive mass-outflow, are generated in the inner shocked region and grow up toward the outer boundary. The advection-dominated accretion flow attains finally in the form of a torus disc with the inner edge of the disc at $3R_{\\rm g} \\le r \\le 6R_{\\rm g}$ and the center at $6R_ {\\rm g} \\le r \\le 10R_{\\rm g}$, and a series...

  5. Constraining black hole masses in low-accreting AGN using X-ray spectra

    CERN Document Server

    Jang, I; Hughes, C; Titarchuk, L

    2014-01-01

    In a recent work we demonstrated that a novel X-ray scaling method, originally introduced for Galactic black holes (GBHs), can be reliably extended to estimate the mass of supermassive black holes accreting at a moderate to high level. Here we investigate the limits of applicability of this method to low-accreting active galactic nuclei, using a control sample with good-quality X-ray data and dynamically measured mass. For low-accreting AGNs, because the basic assumption that the photon index positively correlates with the accretion rate no longer holds the X-ray scaling method cannot be used. Nevertheless, the inverse correlation in the Gamma-Lx/LEdd diagram, found in several low-accreting black holes and confirmed by this sample, can be used to constrain black hole mass within a factor of ~10 from the dynamically determined values. We provide a simple recipe to determine black hole mass using solely X-ray spectral data, which can be used as a sanity check for black hole mass determination based on indirect ...

  6. Effect of accretion on the pre-main-sequence evolution of low-mass stars and brown dwarfs

    Science.gov (United States)

    Vorobyov, Eduard I.; Elbakyan, Vardan; Hosokawa, Takashi; Sakurai, Yuya; Guedel, Manuel; Yorke, Harold

    2017-09-01

    Aims: The pre-main-sequence evolution of low-mass stars and brown dwarfs is studied numerically starting from the formation of a protostellar or proto-brown dwarf seed and taking into account the mass accretion onto the central object during the initial several Myr of evolution. Methods: The stellar evolution was computed using the STELLAR evolution code with recent modifications. The mass accretion rates were taken from numerical hydrodynamics models by computing the circumstellar disk evolution starting from the gravitational collapse of prestellar cloud cores of various mass and angular momentum. The resulting stellar evolution tracks were compared with the isochrones and isomasses calculated using non-accreting models. Results: We find that mass accretion in the initial several Myr of protostellar evolution can have a strong effect on the subsequent evolution of young stars and brown dwarfs. The disagreement between accreting and non-accreting models in terms of the total stellar luminosity L∗, stellar radius R∗, and effective temperature Teff depends on the thermal efficiency of accretion, that is, on the fraction of accretion energy that is absorbed by the central object. The largest mismatch is found for the cold accretion case, in which essentially all accretion energy is radiated away. The relative deviations in L∗ and R∗ in this case can reach 50% for objects 1.0 Myr old, and they remain notable even for objects 10 Myr old. In the hot and hybrid accretion cases, in which a constant fraction of accretion energy is absorbed, the disagreement between accreting and non-accreting models becomes less pronounced, but still remains notable for objects 1.0 Myr old. These disagreements may lead to an incorrect age estimate for objects of (sub-)solar mass when using the isochrones that are based on non-accreting models, as has also been noted previously. We find that objects with strong luminosity bursts exhibit notable excursions in the L∗-Teff diagram

  7. Self-consistent evolution of accreting low-mass stars and brown dwarfs

    CERN Document Server

    Baraffe, I; Vorobyov, E I; Chabrier, G

    2016-01-01

    We present self-consistent calculations coupling numerical hydrodynamics simulations of collapsing pre-stellar cores and stellar evolution models of accreting objects. We analyse the main impact of consistent accretion history on the evolution and lithium depletion of young low-mass stars and brown dwarfs. These consistent models confirm the generation of a luminosity spread in Herzsprung-Russell diagrams at ages $\\sim$ 1-10 Myr. They also confirm that early accretion can produce objects with abnormal Li depletion, as found in a previous study that was based on arbitrary accretion rates. The results strengthen that objects with anomalously high level of Li depletion in young clusters should be extremely rare. We also find that early phases of burst accretion can produce coeval models of similar mass with a range of different Li surface abundances, and in particular with Li-excess compared to the predictions of non-accreting counterparts. This result is due to a subtle competition between the effect of burst a...

  8. The Influence of Black Hole Mass and Accretion Rate on the FRI/FRII Radio Galaxy Dichotomy

    Science.gov (United States)

    Wold, M.; Lacy, M.; Armus, L.

    We use medium resolution optical spectra of 3CR radio galaxies to estimate their black hole masses and accretion rates. Black hole masses are found from central stellar velocity dispersions, and accretion rates are derived from narrow emission-line luminosities. The sample covers both Fanaroff-Riley (FR) classes; the more powerful FRIIs and the less powerful FRIs. We find that FRIs and FRIIs separate in diagrams of radio luminosity and narrow-line luminosity versus black hole mass. This suggests that, at a given black hole mass, the FRIIs accrete more efficiently, or accrete more matter, than FRIs.

  9. Mechanosensitive molecular networks involved in transducing resistance exercise-signals into muscle protein accretion

    Directory of Open Access Journals (Sweden)

    Emil Rindom

    2016-11-01

    Full Text Available Loss of skeletal muscle myofibrillar protein with disease and/or inactivity can severely deteriorate muscle strength and function. Strategies to counteract wasting of muscle myofibrillar protein are therefore desirable and invite for considerations on the potential superiority of specific modes of resistance exercise and/or the adequacy of low load resistance exercise regimens as well as underlying mechanisms. In this regard, delineation of the potentially mechanosensitive molecular mechanisms underlying muscle protein synthesis (MPS, may contribute to understanding on how differentiated resistance exercise can transduce a mechanical signal into stimulation of muscle accretion. Recent findings suggest specific upstream exercise-induced mechano-sensitive myocellular signaling pathways to converge on mammalian target of rapamycin complex 1 (mTORC1, to influence MPS. This may e.g. implicate mechanical activation of signaling through a diacylglycerol kinase (DGKζ-phosphatidic acid (PA axis or implicate integrin deformation to signal through a Focal adhesion kinase (FAK-Tuberous Sclerosis Complex 2TSC2-Ras homolog enriched in brain (Rheb axis. Moreover, since initiation of translation is reliant on mRNA, it is also relevant to consider potentially mechanosensitive signaling pathways involved in muscle myofibrillar gene transcription and whether some of these pathways converge with those affecting mTORC1 activation for MPS. In this regard, recent findings suggest how mechanical stress may implicate integrin deformation and/or actin dynamics to signal through a Ras homolog gene family member A protein (RhoA-striated muscle activator of Rho signaling (STARS axis or how it may implicate deformation of Notch to affect Bone Morphogenetic Protein (BMP signaling through a small mother of decapentaplegic (Smad axis.

  10. Mechanosensitive Molecular Networks Involved in Transducing Resistance Exercise-Signals into Muscle Protein Accretion

    Science.gov (United States)

    Rindom, Emil; Vissing, Kristian

    2016-01-01

    Loss of skeletal muscle myofibrillar protein with disease and/or inactivity can severely deteriorate muscle strength and function. Strategies to counteract wasting of muscle myofibrillar protein are therefore desirable and invite for considerations on the potential superiority of specific modes of resistance exercise and/or the adequacy of low load resistance exercise regimens as well as underlying mechanisms. In this regard, delineation of the potentially mechanosensitive molecular mechanisms underlying muscle protein synthesis (MPS), may contribute to an understanding on how differentiated resistance exercise can transduce a mechanical signal into stimulation of muscle accretion. Recent findings suggest specific upstream exercise-induced mechano-sensitive myocellular signaling pathways to converge on mammalian target of rapamycin complex 1 (mTORC1), to influence MPS. This may e.g. implicate mechanical activation of signaling through a diacylglycerol kinase (DGKζ)-phosphatidic acid (PA) axis or implicate integrin deformation to signal through a Focal adhesion kinase (FAK)-Tuberous Sclerosis Complex 2 (TSC2)-Ras homolog enriched in brain (Rheb) axis. Moreover, since initiation of translation is reliant on mRNA, it is also relevant to consider potentially mechanosensitive signaling pathways involved in muscle myofibrillar gene transcription and whether some of these pathways converge with those affecting mTORC1 activation for MPS. In this regard, recent findings suggest how mechanical stress may implicate integrin deformation and/or actin dynamics to signal through a Ras homolog gene family member A protein (RhoA)-striated muscle activator of Rho signaling (STARS) axis or implicate deformation of Notch to affect Bone Morphogenetic Protein (BMP) signaling through a small mother of decapentaplegic (Smad) axis. PMID:27909410

  11. Mechanosensitive Molecular Networks Involved in Transducing Resistance Exercise-Signals into Muscle Protein Accretion.

    Science.gov (United States)

    Rindom, Emil; Vissing, Kristian

    2016-01-01

    Loss of skeletal muscle myofibrillar protein with disease and/or inactivity can severely deteriorate muscle strength and function. Strategies to counteract wasting of muscle myofibrillar protein are therefore desirable and invite for considerations on the potential superiority of specific modes of resistance exercise and/or the adequacy of low load resistance exercise regimens as well as underlying mechanisms. In this regard, delineation of the potentially mechanosensitive molecular mechanisms underlying muscle protein synthesis (MPS), may contribute to an understanding on how differentiated resistance exercise can transduce a mechanical signal into stimulation of muscle accretion. Recent findings suggest specific upstream exercise-induced mechano-sensitive myocellular signaling pathways to converge on mammalian target of rapamycin complex 1 (mTORC1), to influence MPS. This may e.g. implicate mechanical activation of signaling through a diacylglycerol kinase (DGKζ)-phosphatidic acid (PA) axis or implicate integrin deformation to signal through a Focal adhesion kinase (FAK)-Tuberous Sclerosis Complex 2 (TSC2)-Ras homolog enriched in brain (Rheb) axis. Moreover, since initiation of translation is reliant on mRNA, it is also relevant to consider potentially mechanosensitive signaling pathways involved in muscle myofibrillar gene transcription and whether some of these pathways converge with those affecting mTORC1 activation for MPS. In this regard, recent findings suggest how mechanical stress may implicate integrin deformation and/or actin dynamics to signal through a Ras homolog gene family member A protein (RhoA)-striated muscle activator of Rho signaling (STARS) axis or implicate deformation of Notch to affect Bone Morphogenetic Protein (BMP) signaling through a small mother of decapentaplegic (Smad) axis.

  12. Is Episodic Accretion Necessary to Resolve the Luminosity Problem in Low-Mass Protostars?

    Science.gov (United States)

    Sevrinsky, Raymond Andrew; Dunham, Michael

    2017-01-01

    In this contribution, we compare the results of protostellar accretion simulations for scenarios both containing and lacking episodic accretion activity. We determine synthetic observational signatures for collapsing protostars by taking hydrodynamical simulations predicting highly variable episodic accretion events, filtering out the stochastic behavior by applying power law fits to the mass accretion rates onto the disk and central star, and using the filtered rates as inputs to two-dimensional radiative transfer calculations. The spectral energy distributions generated by these calculations are used to calculate standard observational signatures of Lbol and Tbol, and compared directly to a sample of 230 embedded protostars. We explore the degree to which these continually declining accretion models successfully reproduce the observed spread of protostellar luminosities, and examine their consistency with the prior variable models to investigate the degree to which episodic accretion bursts are necessary in protostellar formation theories to match observations of field protostars. The SAO REU program is funded in part by the National Science Foundation REU and Department of Defense ASSURE programs under NSF Grant no. 1262851, and by the Smithsonian Institution.

  13. Estimation of mass outflow rates from viscous relativistic accretion discs around black holes

    CERN Document Server

    Chattopadhyay, Indranil

    2016-01-01

    We investigated flow in Schwarzschild metric, around a non-rotating black hole and obtained self-consistent accretion - ejection solution in full general relativity. We covered the whole of parameter space in the advective regime to obtain shocked, as well as, shock-free accretion solution. We computed the jet streamline using von - Zeipel surfaces and projected the jet equations of motion on to the streamline and solved them simultaneously with the accretion disc equations of motion. We found that steady shock cannot exist {for $\\alpha \\gsim0.06$} in the general relativistic prescription, but is lower if mass - loss is considered too. We showed that for fixed outer boundary, the shock moves closer to the horizon with increasing viscosity parameter. The mass outflow rate increases as the shock moves closer to the black hole, but eventually decreases, maximizing at some intermediate value of shock {location}. The jet terminal speed increases with stronger shocks, quantitatively speaking, the terminal speed of ...

  14. The relation between accretion rates and the initial mass function in hydrodynamical simulations of star formation

    CERN Document Server

    Maschberger, Th; Clarke, C J; Moraux, E

    2013-01-01

    We analyse a hydrodynamical simulation of star formation. Sink particles in the simulations which represent stars show episodic growth, which is presumably accretion from a core that can be regularly replenished in response to the fluctuating conditions in the local environment. The accretion rates follow $\\dot{m} \\propto m^{2/3}$, as expected from accretion in a gas-dominated potential, but with substantial variations over-laid on this. The growth times follow an exponential distribution which is tapered at long times due to the finite length of the simulation. The initial collapse masses have an approximately lognormal distribution with already an onset of a power-law at large masses. The sink particle mass function can be reproduced with a non-linear stochastic process, with fluctuating accretion rates $\\propto m^{2/3}$, a distribution of seed masses and a distribution of growth times. All three factors contribute equally to the form of the final sink mass function. We find that the upper power law tail of...

  15. Does an Average White Dwarf Have Enough Mass to Prevent an Accretion Disk Tilt?

    CERN Document Server

    Montgomery, M M

    2010-01-01

    In a recent publication, we introduce the lift force as a common source to accretion disk tilt that is likely relevant to accretion disk systems. Lift is generated by slightly different supersonic gas stream speeds flowing over and under the disk at the bright spot. In this conference proceeding, we focus on whether the average white dwarf has enough mass to prevent a disk tilt in non-magnetic Cataclysmic Variables (CVs) with accretion disks. Assuming a white dwarf mass of 0.6M$_{\\odot}$ and a disk mass of 10$^{-11}$M$_{\\odot}$, we vary the secondary mass to establish theoretical minimum mass transfer rates needed to induce and maintain a disk tilt of four degrees around the line of nodes. For mass ratios in the range \\( (0.13 \\le q=M_{2}M^{-1} \\le 0.45) \\), we confirm that the secondary mass does not contribute significantly to disk tilt. We also confirm that the average white dwarf does not have enough mass to prevent a disk tilt. We find that disk tilt may be likely in low mass transfer rate systems such a...

  16. Occurrence of instability through the protostellar accretion disks by landing of low-mass condensations

    CERN Document Server

    Elyasi, Mahjubeh

    2016-01-01

    Low-mass condensations (LMCs) are observed inside the envelope of the collapsing molecular cloud cores. In this research, we investigate the effects of landing LMCs for occurrence of instability through the protostellar accretion disks. We consider some regions of the disk where duration of infalling and landing of the LMCs are shorter than the orbital period. In this way, we can consider the landing LMCs as density bumps and grooves in the azimuthal direction of an initial thin axisymmetric steady state self-gravitating protostellar accretion disk (nearly Keplerian). Using the linear effects of the bump quantities, we obtain a characteristic equation for growth/decay rate of bumps; we numerically solve it to find occurrence of instability. We also evaluate the minimum-growth-time-scale (MGTS) and the enhanced mass accretion rate. The results show that infalling and landing of the LMCs in the inner regions of the protostellar accretion disks can cause faster unstable modes and less enhanced accretion rates re...

  17. Do Circumnuclear Dense Gas Disks Drive Mass Accretion onto Supermassive Black Holes?

    Science.gov (United States)

    Izumi, Takuma; Kawakatu, Nozomu; Kohno, Kotaro

    2016-08-01

    We present a positive correlation between the mass of dense molecular gas ({M}{{dense}}) of ˜100 pc scale circumnuclear disks (CNDs) and the black hole mass accretion rate ({\\dot{M}}{{BH}}) in a total of 10 Seyfert galaxies, based on data compiled from the literature and an archive (median aperture θ med = 220 pc). A typical {M}{{dense}} of CNDs is 107-8 {M}⊙ , estimated from the luminosity of the dense gas tracer, the HCN(1-0) emission line. Because dense molecular gas is the site of star formation, this correlation is virtually equivalent to the one between the nuclear star-formation rate and {\\dot{M}}{{BH}} revealed previously. Moreover, the {M}{{dense}}{--}{\\dot{M}}{{BH}} correlation was tighter for CND-scale gas than for the gas on kiloparsec or larger scales. This indicates that CNDs likely play an important role in fueling black holes, whereas greater than kiloparesec scale gas does not. To demonstrate a possible approach for studying the CND-scale accretion process with the Atacama Large Millimeter/submillimeter Array, we used a mass accretion model where angular momentum loss due to supernova explosions is vital. Based on the model prediction, we suggest that only the partial fraction of the mass accreted from the CND ({\\dot{M}}{{acc}}) is consumed as {\\dot{M}}{{BH}}. However, {\\dot{M}}{{acc}} agrees well with the total nuclear mass flow rate (i.e., {\\dot{M}}{{BH}} + outflow rate). Although these results are still tentative with large uncertainties, they support the view that star formation in CNDs can drive mass accretion onto supermassive black holes in Seyfert galaxies.

  18. The Role of Angular Momentum Transport in Establishing the Accretion Rate--Protostellar Mass Correlation

    CERN Document Server

    DeSouza, Alexander L

    2016-01-01

    We model the mass accretion rate $\\dot{M}$ to stellar mass $M_*$ correlation that has been inferred from observations of intermediate to upper mass T Tauri stars---that is $\\dot{M} \\propto M_*^{1.3 \\pm 0.3}$. We explain this correlation within the framework of quiescent disk evolution, in which accretion is driven largely by gravitational torques acting in the bulk of the mass and volume of the disk. Stresses within the disk arise from the action of gravitationally driven torques parameterized in our 1D model in terms of Toomre's $Q$ criterion. We do not model the hot inner sub-AU scale region of the disk that is likely stable according to this criterion, and appeal to other mechanisms to remove or redistribute angular momentum and allow accretion onto the star. Our model has the advantage of agreeing with large-scale angle-averaged values from more complex nonaxisymmetric calculations. The model disk transitions from an early phase (dominated by initial conditions inherited from the burst mode of accretion) ...

  19. THE STRUCTURE OF GAS-ACCRETING PROTOPLANETS AND THE CONDITION OF THE CRITICAL CORE MASS

    Energy Technology Data Exchange (ETDEWEB)

    Kanagawa, Kazuhiro D. [Department of Cosmosciences, Graduate School of Science, Hokkaido University, N10 W8, Sapporo 060-0810 (Japan); Fujimoto, Masayuki Y., E-mail: kanagawa@astro1.sci.hokudai.ac.jp [Nuclear Reaction Data Center, Graduate School of Science, Hokkaido University, Kita 10 Nishi 8, Kita-ku, Sapporo 060-0810 (Japan)

    2013-03-01

    In the core accretion model for the formation of gas giant planets, runaway gas accretion onto a core is the primary requisite, triggered when the core mass reaches a critical value. The recently revealed wide diversity of the extrasolar giant planets suggests the necessity to further the understanding of the conditions resulting in the critical core mass that initiates runaway accretion. We study the internal structure of protoplanets under hydrostatic and thermal equilibria represented in terms of a polytropic equation of state to investigate what factors determine and affect the critical core mass. We find that the protoplanets, embedded in protoplanetary disks, have the same configuration as red giants, characterized by the envelope of the centrally condensed type solution. Applying the theory of stellar structure with homology invariants, we demonstrate that there are three types of criteria for the critical core mass depending on the stiffness of polytrope and the nature of outer boundary condition. For the stiff polytropes of index N {<=} 3 with the Bondi radius as the outer boundary, the criterion governing the critical core mass occurs at the surface. For stiff polytropes with the Hill outer boundary and for soft polytropes of N > 3, this criterion acts at the bottom of gaseous envelope. Further, we elucidate the roles and effects of coexistent radiative and convective zones in the envelope of critical core mass. Based on the results, we discuss the relevance of Bondi and Hill surface conditions and explore the parameter dependences of critical core mass.

  20. The role of angular momentum transport in establishing the accretion rate-protostellar mass correlation

    Science.gov (United States)

    DeSouza, Alexander L.; Basu, Shantanu

    2017-02-01

    We model the mass accretion rate M˙ to stellar mass M* correlation that has been inferred from observations of intermediate to upper mass T Tauri stars-that is M˙ ∝ M*1.3±0.3. We explain this correlation within the framework of quiescent disk evolution, in which accretion is driven largely by gravitational torques acting in the bulk of the mass and volume of the disk. Stresses within the disk arise from the action of gravitationally driven torques parameterized in our 1D model in terms of Toomre's Q criterion. We do not model the hot inner sub-AU scale region of the disk that is likely stable according to this criterion, and appeal to other mechanisms to remove or redistribute angular momentum and allow accretion onto the star. Our model has the advantage of agreeing with large-scale angle-averaged values from more complex nonaxisymmetric calculations. The model disk transitions from an early phase (dominated by initial conditions inherited from the burst mode of accretion) into a later self-similar mode characterized by a steeper temporal decline in M˙. The models effectively reproduce the spread in mass accretion rates that have been observed for protostellar objects of 0.2 M⊙ ≤ M* ≤ 3.0 M⊙, such as those found in the ρ Ophiuchus and Taurus star forming regions. We then compare realistically sampled populations of young stellar objects produced by our model to their observational counterparts. We find these populations to be statistically coincident, which we argue is evidence for the role of gravitational torques in the late time evolution of quiescent protostellar disks.

  1. On the stream-accretion disk interaction - Response to increased mass transfer rate

    Science.gov (United States)

    Dgani, Ruth; Livio, Mario; Soker, Noam

    1989-01-01

    The time-dependent interaction between the stream of mass from the inner Lagrangian point and the accretion disk, resulting from an increasing mass transfer rate is calculated. The calculation is fully three-dimensional, using a pseudoparticle description of the hydrodynamics. It is demonstrated that the results of such calculations, when combined with specific observations, have the potential of both determining essential parameters, such as the viscosity parameter alpha, and can distinguish between different models of dwarf nova eruptions.

  2. Estimation of mass outflow rates from viscous relativistic accretion discs around black holes

    Science.gov (United States)

    Chattopadhyay, Indranil; Kumar, Rajiv

    2016-07-01

    We investigated flow in Schwarzschild metric, around a non-rotating black hole and obtained self-consistent accretion-ejection solution in full general relativity. We covered the whole of parameter space in the advective regime to obtain shocked, as well as, shock-free accretion solution. We computed the jet streamline using von Zeipel surfaces and projected the jet equations of motion on to the streamline and solved them simultaneously with the accretion disc equations of motion. We found that steady shock cannot exist beyond α ≳ 0.06 in the general relativistic prescription, but is lower if mass-loss is considered too. We showed that for fixed outer boundary, the shock moves closer to the horizon with increasing viscosity parameter. The mass outflow rate increases as the shock moves closer to the black hole, but eventually decreases, maximizing at some intermediate value of shock location. The jet terminal speed increases with stronger shocks; quantitatively speaking, the terminal speed of jets vj∞ > 0.1 if rsh < 20rg. The maximum of the outflow rate obtained in the general relativistic regime is less than 6 per cent of the mass accretion rate.

  3. The Ionization of Accretion Flows in High Mass Star Formation: W51e2

    CERN Document Server

    Keto, Eric

    2008-01-01

    Previous observations show that the hypercompact HII region W51e2 is surrounded by a massive molecular accretion flow centered on the HII region. New observations of the H53alpha radio recombination line made with the VLA at 0.45 arc second angular resolution show a velocity gradient in the ionized gas within the HII region of > 500 kms-1 pc-1 comparable to the velocity gradient seen in the molecular accretion flow. New CO line observations made with the SMA at arc second angular resolution detect a molecular bipolar outflow immediately around the W51e2 HII region and extending along the axis of rotation of the molecular flow. These observations are consistent with an evolutionary phase for high mass star formation in which a newly formed massive star first begins to ionize its surroundings including its own accretion flow.

  4. The evolution of the mass ratio of accreting binaries: the role of gas temperature

    CERN Document Server

    Young, Matthew D; Clarke, Cathie J

    2014-01-01

    We explore an unresolved controversy in the literature about the accuracy of Smoothed Particle Hydrodynamics (SPH) in modeling the accretion of gas onto a binary system, a problem with important applications to the evolution of proto-binaries as well as accreting binary super massive black holes. It has previously been suggested that SPH fails to model the flow of loosely bound material from the secondary to primary Roche lobe and that its general prediction that accretion drives mass ratios upwards is numerically flawed. Here we show with 2D SPH that this flow from secondary to primary Roche lobe is a sensitive function of gas temperature and that this largely explains the conflicting claims in the literature which have hitherto been based on either 'cold' SPH simulations or 'hot' grid based calculations. We present simulations of a specimen 'cold' and 'hot' accretion scenario which are numerically converged and evolved into a steady state. Our analysis of the conservation of the Jacobi integral of accreting...

  5. Low-mass gas envelopes around accreting cores embedded in radiative 3D discs

    Science.gov (United States)

    Lega, Elena; Lambrechts, Michiel

    2016-10-01

    Planets with a core mass larger than few Earth masses and a gaseous envelope not exceeding about 10% of the total mass budget are common. Such planets are present in the Solar System (Uranus, Neptune) and are frequently observed around other stars.Our knowledge about the evolution of gas envelopes is mainly based on 1D models. However, such models cannot investigate the complex interaction between the forming envelope and the surrounding gas disc.In this work we perform 3D hydrodynamics simulations accounting for energy transfer and radiative cooling using the FARGOCA code (Lega et al., MNRAS 440, 2014). In addition to the usually considered heatingsources, namely viscous and compressional heating, we have modeled the energy deposited by the accretion of solids.We show that the thermal evolution of the envelope of a 5 Earth mass core is mainly dominated by compressional heating for accretion rates lower than 5 Earth masses per 105 years.Additionally, we demonstrate efficient gas circulation through the envelope. Under certain conditions, the competition between gas circulation and cooling of the envelope can efficiently delay the onset of runaway accretion. This could help in explaining the population of planets with low-mass gas envelope.

  6. Clumpy wind accretion in supergiant neutron star high mass X-ray binaries

    Science.gov (United States)

    Bozzo, E.; Oskinova, L.; Feldmeier, A.; Falanga, M.

    2016-05-01

    The accretion of the stellar wind material by a compact object represents the main mechanism powering the X-ray emission in classical supergiant high mass X-ray binaries and supergiant fast X-ray transients. In this work we present the first attempt to simulate the accretion process of a fast and dense massive star wind onto a neutron star, taking into account the effects of the centrifugal and magnetic inhibition of accretion ("gating") due to the spin and magnetic field of the compact object. We made use of a radiative hydrodynamical code to model the nonstationary radiatively driven wind of an O-B supergiant star and then place a neutron star characterized by a fixed magnetic field and spin period at a certain distance from the massive companion. Our calculations follow, as a function of time (on a total timescale of several hours), the transitions of the system through all different accretion regimes that are triggered by the intrinsic variations in the density and velocity of the nonstationary wind. The X-ray luminosity released by the system is computed at each time step by taking into account the relevant physical processes occurring in the different accretion regimes. Synthetic lightcurves are derived and qualitatively compared with those observed from classical supergiant high mass X-ray binaries and supergiant fast X-ray transients. Although a number of simplifications are assumed in these calculations, we show that taking into account the effects of the centrifugal and magnetic inhibition of accretion significantly reduces the average X-ray luminosity expected for any neutron star wind-fed binary. The present model calculations suggest that long spin periods and stronger magnetic fields are favored in order to reproduce the peculiar behavior of supergiant fast X-ray transients in the X-ray domain.

  7. The jets-accretion relation, mass-luminosity relation in Fermi blazars

    Science.gov (United States)

    Yu, Xiaoling; Zhang, Xiong; Zhang, Haojing; Xiong, Dingrong; Li, Bijun; Cha, Yongjuan; Chen, Yongyun; Huang, Xia; Wang, Yuwei

    2015-05-01

    A sample of 111 Fermi blazars each with a well-established radio core luminosity, broad-line luminosity, bolometric luminosity and black hole mass has been compiled from the literatures. We present a significant correlation between radio core and broad-line emission luminosities that supports a close link between accretion processes and relativistic jets. Analysis reveals a relationship of which is consistant with theoretical predicted coefficient and supports that blazar jets are powered by energy extraction from a rapidly spinning Kerr black hole through the magnetic field provided by the accretion disk. Through studying the correlation between the intrinsic bolometric luminosity and the black hole mass, we find a relationship of which supports mass-luminosity relation for Fermi blazars derived in this work is a powerlaw relation similar to that for main-sequence stars. Finally, EVOLUTIONARY SEQUENCE OF BLAZARS is discussed.

  8. Is Main Sequence Galaxy Star Formation Controlled by Halo Mass Accretion?

    CERN Document Server

    Rodriguez-Puebla, Aldo; Behroozi, Peter; Faber, S M

    2015-01-01

    It is known that the galaxy stellar-to-halo mass ratio (SHMR) is nearly independent of redshift from z=0-4. This motivates us to construct a toy model in which we assume that the SMHR for central galaxies measured at redshift z~0 is independent of redshift, which implies that the star formation rate (SFR) is determined by the halo mass accretion rate, a phenomenon we call Stellar-Halo Accretion Rate Coevolution (SHARC). Moreover, we show here that the ~0.3 dex dispersion of the halo mass accretion rate (MAR) is similar to the observed dispersion of the SFR on the main sequence. In the context of bathtub-type models of galaxy formation, SHARC leads to mass-dependent constraints on the relation between SFR and MAR. The SHARC assumption is no doubt over-simplified, but we expect it to be possibly valid for central galaxies with stellar masses of 10^9 - 10^10.5 M_sol that are on the star formation main sequence. Such galaxies represent most of the life history of M_* galaxies, and therefore most of the star forma...

  9. Energy, momentum and mass outflows and feedback from thick accretion discs around rotating black holes

    CERN Document Server

    Sadowski, A; Penna, R; Zhu, Y

    2013-01-01

    A set of long-duration general relativistic magnetohydrodynamic simulations of radiatively inefficient accretion discs around rotating black holes are presented, and are used to estimate the energy, mass and momentum outflow rates from such systems. Outflows occur via two fairly distinct modes: a relativistic jet and a sub-relativistic wind. The jet power depends strongly on the black hole spin and on the magnetic flux at the horizon. Unless these are very small, the energy output in the jet dominates over that in the wind. In the limit of a rapidly spinning black hole accreting in the magnetically arrested limit, when the magnetic flux at the black hole is maximum, the jet power exceeds the total rate of accretion of rest mass energy. However, because of strong collimation, the jet probably does not have a significant effect on its surrounding. In the case of an accreting supermassive black hole, external feedback via a jet is likely important only on the largest galaxy cluster scales. The power in the wind ...

  10. Cosmic Evolution of Mass Accretion Rate and Metalicity in Active Galactic Nuclei

    CERN Document Server

    Netzer, H; Netzer, Hagai; Trakhtenbrot, Benny

    2006-01-01

    We present line and continuum measurements for 9818 SDSS type-I active galactic nuclei (AGNs) with z le 0.75. The data are used to study the four dimensional space of black hole mass, normalized accretion rate (Ledd), metalicity and redshift. The main results are: 1. Ledd is smaller for larger mass black holes at all redshifts. 2. For a given black hole mass Ledd propto z^gamma or (1+z)^delta where the slope gamma increases with black hole mass. The mean slope is similar to the star formation rate slope over the same redshift interval. 3. The FeII/Hb line ratio is significantly correlated with Ledd. It also shows a weaker negative dependence on redshift. Combined with the known dependence of metalicity on accretion rate, we suggest that the FeII/Hb line ratio is a metalicity indicator. 4. Given the measured accretion rates, the growth times of most AGNs exceed the age of the universe. This suggests past episodes of faster growth for all those sources. Combined with the FeII/Hb result, we conclude that the bro...

  11. Accretion Disks Around Binary Black Holes of Unequal Mass: GRMHD Simulations Near Decoupling

    Science.gov (United States)

    Gold, Roman; Paschalidis, Vasileios; Etienne, Zachariah B.; Shapiro, Stuart L.; Pfeiffer, Harald, P.

    2013-01-01

    We report on simulations in general relativity of magnetized disks onto black hole binaries. We vary the binary mass ratio from 1:1 to 1:10 and evolve the systems when they orbit near the binary disk decoupling radius. We compare (surface) density profiles, accretion rates (relative to a single, non-spinning black hole), variability, effective alpha-stress levels and luminosities as functions of the mass ratio. We treat the disks in two limiting regimes: rapid radiative cooling and no radiative cooling. The magnetic field lines clearly reveal jets emerging from both black hole horizons and merging into one common jet at large distances. The magnetic fields give rise to much stronger shock heating than the pure hydrodynamic flows, completely alter the disk structure, and boost accretion rates and luminosities. Accretion streams near the horizons are among the densest structures; in fact, the 1:10 no-cooling evolution results in a refilling of the cavity. The typical effective temperature in the bulk of the disk is approx. 10(exp5) (M / 10(exp 8)M solar mass (exp -1/4(L/L(sub edd) (exp 1/4K) yielding characteristic thermal frequencies approx. 10 (exp 15) (M /10(exp 8)M solar mass) (exp -1/4(L/L (sub edd) (1+z) (exp -1)Hz. These systems are thus promising targets for many extragalactic optical surveys, such as LSST, WFIRST, and PanSTARRS.

  12. Conditions for circumstellar disc formation - II. Effects of initial cloud stability and mass accretion rate

    Science.gov (United States)

    Machida, Masahiro N.; Matsumoto, Tomoaki; Inutsuka, Shu-ichiro

    2016-12-01

    Disc formation in strongly magnetized cloud cores is investigated using a three-dimensional magnetohydrodynamic simulation with a focus on the effects of the initial cloud stability and the mass accretion rate. The initial cloud stability greatly alters the disc formation process even for prestellar clouds with the same mass-to-flux ratio. A high mass accretion rate on to the disc-forming region is realized in initially unstable clouds, and a large angular momentum is introduced into the circumstellar region in a short time. The region around the protostar has both a thin infalling envelope and a weak magnetic field, which both weaken the effect of magnetic braking. The growth of the rotation-supported disc is promoted in such unstable clouds. Conversely, clouds in an initially near-equilibrium state show lower accretion rates of mass and angular momentum. The angular momentum is transported to the outer envelope before protostar formation. After protostar formation, the circumstellar region has a thick infalling envelope and a strong magnetic field that effectively brakes the disc. As a result, disc formation is suppressed when the initial cloud is in a nearly stable state. The density distribution of the initial cloud also affects the disc formation process. Disc growth strongly depends on the initial conditions when the prestellar cloud has a uniform density, whereas there is no significant difference in the disc formation process in prestellar clouds with non-uniform densities.

  13. The Eating Habits of Milky Way-mass Halos: Destroyed Dwarf Satellites and the Metallicity Distribution of Accreted Stars

    Science.gov (United States)

    Deason, Alis J.; Mao, Yao-Yuan; Wechsler, Risa H.

    2016-04-01

    We study the mass spectrum of destroyed dwarfs that contribute to the accreted stellar mass of Milky Way (MW)-mass (Mvir ˜ 1012.1 M⊙) halos using a suite of 45 zoom-in dissipationless simulations. Empirical models are employed to relate (peak) subhalo mass to dwarf stellar mass, and we use constraints from z = 0 observations and hydrodynamical simulations to estimate the metallicity distribution of the accreted stellar material. The dominant contributors to the accreted stellar mass are relatively massive dwarfs with Mstar ˜ 108-1010M⊙. Halos with more quiescent accretion histories tend to have lower mass progenitors (108-109 M⊙), and lower overall accreted stellar masses. Ultra-faint mass (Mstar 108 M⊙ can contribute a considerable fraction (˜20%-60%) of metal-poor stars if their metallicity distributions have significant metal-poor tails. Finally, we find that the generic assumption of a quiescent assembly history for the MW halo seems to be in tension with the mass spectrum of its surviving dwarfs. We suggest that the MW could be a “transient fossil” a quiescent halo with a recent accretion event(s) that disguises the preceding formation history of the halo.

  14. A Hot and Massive Accretion Disk around the High-mass Protostar IRAS 20126+4104

    Science.gov (United States)

    Chen, Huei-Ru Vivien; Keto, Eric; Zhang, Qizhou; Sridharan, T. K.; Liu, Sheng-Yuan; Su, Yu-Nung

    2016-06-01

    We present new spectral line observations of the CH3CN molecule in the accretion disk around the massive protostar IRAS 20126+4104 with the Submillimeter Array, which, for the first time, measure the disk density, temperature, and rotational velocity with sufficient resolution (0.″37, equivalent to ˜600 au) to assess the gravitational stability of the disk through the Toomre-Q parameter. Our observations resolve the central 2000 au region that shows steeper velocity gradients with increasing upper state energy, indicating an increase in the rotational velocity of the hotter gas nearer the star. Such spin-up motions are characteristics of an accretion flow in a rotationally supported disk. We compare the observed data with synthetic image cubes produced by three-dimensional radiative transfer models describing a thin flared disk in Keplerian motion enveloped within the centrifugal radius of an angular-momentum-conserving accretion flow. Given a luminosity of 1.3 × 104 L ⊙, the optimized model gives a disk mass of 1.5 M ⊙ and a radius of 858 au rotating about a 12.0 M ⊙ protostar with a disk mass accretion rate of 3.9 × 10-5 M ⊙ yr-1. Our study finds that, in contrast to some theoretical expectations, the disk is hot and stable to fragmentation with Q > 2.8 at all radii which permits a smooth accretion flow. These results put forward the first constraints on gravitational instabilities in massive protostellar disks, which are closely connected to the formation of companion stars and planetary systems by fragmentation.

  15. Dependence of the outer density profiles of halos on their mass accretion rate

    Energy Technology Data Exchange (ETDEWEB)

    Diemer, Benedikt; Kravtsov, Andrey V., E-mail: bdiemer@oddjob.uchicago.edu [Department of Astronomy and Astrophysics, The University of Chicago, Chicago, IL 60637 (United States)

    2014-07-01

    We present a systematic study of the density profiles of ΛCDM halos, focusing on the outer regions, 0.1 < r/R {sub vir} < 9. We show that the median and mean profiles of halo samples of a given peak height exhibit significant deviations from the universal analytic profiles discussed previously in the literature, such as the Navarro-Frenk-White and Einasto profiles, at radii r ≳ 0.5R {sub 200m}. In particular, at these radii the logarithmic slope of the median density profiles of massive or rapidly accreting halos steepens more sharply than predicted. The steepest slope of the profiles occurs at r ≈ R {sub 200m}, and its absolute value increases with increasing peak height or mass accretion rate, reaching slopes of –4 and steeper. Importantly, we find that the outermost density profiles at r ≳ R {sub 200m} are remarkably self-similar when radii are rescaled by R {sub 200m}. This self-similarity indicates that radii defined with respect to the mean density are preferred for describing the structure and evolution of the outer profiles. However, the inner density profiles are most self-similar when radii are rescaled by R {sub 200c}. We propose a new fitting formula that describes the median and mean profiles of halo samples selected by their peak height or mass accretion rate with accuracy ≲ 10% at all radii, redshifts, and masses we studied, r ≲ 9R {sub vir}, 0 < z < 6, and M {sub vir} > 1.7 × 10{sup 10} h {sup –1} M {sub ☉}. We discuss observational signatures of the profile features described above and show that the steepening of the outer profile should be detectable in future weak-lensing analyses of massive clusters. Such observations could be used to estimate the mass accretion rate of cluster halos.

  16. Formation of Massive Primordial Stars: Intermittent UV Feedback with Episodic Mass Accretion

    CERN Document Server

    Hosokawa, Takashi; Kuiper, Rolf; Yorke, Harold W; Omukai, Kazuyuki; Yoshida, Naoki

    2015-01-01

    We present coupled stellar evolution (SE) and 3D radiation-hydrodynamic (RHD) simulations of the evolution of primordial protostars, their immediate environment, and the dynamic accretion history under the influence of stellar ionizing and dissociating UV feedback. Our coupled SE-RHD calculations result in a wide diversity of final stellar masses covering $10~M_\\odot \\lesssim M_* \\lesssim 10^3~M_\\odot$. The formation of very massive ($\\gtrsim 250~M_\\odot$) stars is possible under weak UV feedback, whereas ordinary massive (a few $\\times 10~M_\\odot$) stars form when UV feedback can efficiently halt the accretion. Weak UV feedback occurs in cases of variable accretion, in particular when repeated short accretion bursts temporarily exceed $0.01~M_\\odot~{\\rm yr}^{-1}$, causing the protostar to inflate. In the bloated state, the protostar has low surface temperature and UV feedback is suppressed until the star eventually contracts, on a thermal adjustment timescale, to create an HII region. If the delay time betwe...

  17. Clumpy wind accretion in supergiant neutron star high mass X-ray binaries

    CERN Document Server

    Bozzo, E; Feldmeier, A; Falanga, M

    2016-01-01

    The accretion of the stellar wind material by a compact object represents the main mechanism powering the X-ray emission in classical supergiant high mass X-ray binaries and supergiant fast X-ray transients. In this work we present the first attempt to simulate the accretion process of a fast and dense massive star wind onto a neutron star, taking into account the effects of the centrifugal and magnetic inhibition of accretion ("gating") due to the spin and magnetic field of the compact object. We made use of a radiative hydrodynamical code to model the non-stationary radiatively driven wind of an O-B supergiant star and then place a neutron star characterized by a fixed magnetic field and spin period at a certain distance from the massive companion. Our calculations follow, as a function of time (on a total time scale of several hours), the transition of the system through all different accretion regimes that are triggered by the intrinsic variations in the density and velocity of the non-stationary wind. Th...

  18. The Source of Mass Accreted by the Central Black Hole in Cooling Flow Clusters

    CERN Document Server

    Soker, N

    2006-01-01

    This paper reports the study of the cold-feedback heating in cooling flow clusters. In the cold-feedback model the mass accreted by the central black hole originates in non-linear over-dense blobs of gas residing in an extended region (r ~ 5-30 kpc); these blobs are originally hot, but then cool faster than their environment and sink toward the center. The intra-cluster medium (ICM) entropy profile must be shallow for the blobs to reach the center as cold blobs. I build a toy model to explore the role of the entropy profile and the population of dense blobs in the cold-feedback mechanism. The mass accretion rate by the central black hole is determined by the cooling time of the ICM, the entropy profile, and the presence of inhomogeneities. The mass accretion rate determines the energy injected by the black hole back to the ICM. These active galactic nucleus (AGN) outbursts not only heat the ICM, but also change the entropy profile in the cluster and cause inhomogeneities that are the seeds of future dense blo...

  19. STABLE AND UNSTABLE REGIMES OF MASS ACCRETION ONTO RW AUR A

    Energy Technology Data Exchange (ETDEWEB)

    Takami, Michihiro; Wei, Yu-Jie; Chou, Mei-Yin; Karr, Jennifer L.; Liu, Hauyu Baobab [Institute of Astronomy and Astrophysics, Academia Sinica, 11F of Astronomy-Mathematics Building, AS/NTU, No.1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan, R.O.C. (China); Beck, Tracy L. [Space Telescope Science Institute, 3700 San Martin Dr., Baltimore, MD 21218 (United States); Manset, Nadine [Canada–France–Hawaii Telescope, 65-1238 Mamalahoa Hwy., Kamuela, HI 96743 (United States); Chen, Wen-Ping [Institute of Astronomy, National Central University, Taiwan 320, Taiwan (China); Kurosawa, Ryuichi [Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Fukagawa, Misato [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); White, Marc [Research School of Astronomy and Astrophysics, The Australian National University, Cotter Rd., Weston, ACT 2611 (Australia); Galván-Madrid, Roberto [Centro de Radioastronomía y Astrofísica, UNAM, Apdo. Postal 3-72 (Xangari), 58089 Morelia, Michoacán, México (Mexico); Pyo, Tae-Soo [Subaru Telescope, 650 North Aohoku Place, Hilo, HI 96720 (United States); Donati, Jean-Francois, E-mail: hiro@asiaa.snica.edu.tw [UPS-Toulouse/CNRS-INSU, Institut de Recherche en Astrophysique et Plańetologie (IRAP) UMR 5277, Toulouse F-31400 (France)

    2016-04-01

    We present monitoring observations of the active T Tauri star RW Aur, from 2010 October to 2015 January, using optical high-resolution (R ≥ 10,000) spectroscopy with Canada–France–Hawaii Telescope/ESPaDOnS. Optical photometry in the literature shows bright, stable fluxes over most of this period, with lower fluxes (by 2–3 mag) in 2010 and 2014. In the bright period our spectra show clear photospheric absorption, complicated variation in the Ca ii λ8542 emission profile shapes, and a large variation in redshifted absorption in the O i λλ7772 and 8446 and He i λ5876 lines, suggesting unstable mass accretion during this period. In contrast, these line profiles are relatively uniform during the faint periods, suggesting stable mass accretion. During the faint periods, the photospheric absorption lines are absent or marginal, and the averaged Li i profile shows redshifted absorption due to an inflow. We discuss (1) occultation by circumstellar material or a companion and (2) changes in the activity of mass accretion to explain the above results, together with near-infrared and X-ray observations from 2011 to 2015. Neither scenario can simply explain all the observed trends, and more theoretical work is needed to further investigate their feasibilities.

  20. POISSON project - III - Investigating the evolution of the mass accretion rate

    CERN Document Server

    Antoniucci, S; Nisini, B; Garatti, A Caratti o; Giannini, T; Lorenzetti, D

    2014-01-01

    As part of the POISSON project (Protostellar Optical-Infrared Spectral Survey on NTT), we present the results of the analysis of low-resolution NIR spectra 0.9-2.4 um) of two samples of YSOs in Lupus and Serpens (52 and 17 objects), with masses 0.1-2.0 Msun and ages from 10^5 to a few 10^7 yr. After determining the accretion parameters of the Lup and Ser targets by analysing their HI near-IR emission features, we added the results to those from previous regions (investigated in POISSON with the same methodology). We obtained a final catalogue (143 objects) of mass accretion rates (Macc) derived in a homogeneous fashion and analysed how Macc correlates with M* and how it evolves in time. We derived the accretion luminosity (Lacc) and Macc for Lup and Ser objects from the Br_gamma line by using relevant empirical relationships from the literature that connect HI line luminosity and Lacc. To minimise the biases and also for self-consistency, we re-derived mass and age for each source using the same set of evolut...

  1. A Constraint of Black Hole Mass and the Inner Edge Radius of Relativistic Accretion Disc

    Institute of Scientific and Technical Information of China (English)

    HE Liang; HUANG Chang-Yin; WANG Ding-Xiong

    2011-01-01

    A constraint to black hole(BH)accretion has previously been derived for the inner edge fixed at the innermost stable circular orbit(ISCO) and the innermost bound circular orbit(IBCO). This constraint is referred to as the mass-radius(MR) relation in this study, and the validity of the MR relation is discussed for different cases. It is shown that the product of the BH mass and the inner edge radius decreases monotonically in the accretion process for the inner edge located between IBCO and ISCO. In addition, we discuss the validity of the MR relation by considering the magnetic coupling(MC) effects of a Kerr BH with its surrounding disc. Although theoretically the product of the BH mass and the radius of ISCO increases(decreases) with time for a BH spin greater(less)than some critical value in the MC process, this relation is approximately valid for an Eddington accretion rate persisting for a rather long time, such as more than 10(6) years. Finally ,we discuss the possible application of the MR relation to astrophysics.

  2. Stable and Unstable Regimes of Mass Accretion onto RW Aur A

    CERN Document Server

    Takami, Michihiro; Chou, Mei-Yin; Karr, Jennifer L; Beck, Tracy L; Manset, Nadine; Chen, Wen-Ping; Kurosawa, Ryuichi; Fukagawa, Misato; White, Marc; Galvan-Madrid, Roberto; Liu, Hauyu Baobab; Pyo, Tae-Soo; Donati, Jean-Francois

    2016-01-01

    We present monitoring observations of the active T Tauri star RW Aur, from 2010 October to 2015 January, using optical high-resolution (R>10000) spectroscopy with CFHT-ESPaDOnS. Optical photometry in the literature shows bright, stable fluxes over most of this period, with lower fluxes (by 2-3 mag.) in 2010 and 2014. In the bright period our spectra show clear photospheric absorption, complicated variation in the Ca II 8542 A emission}profile shapes, and a large variation in redshifted absorption in the O I 7772 and 8446 A and He I 5876 A lines, suggesting unstable mass accretion during this period. In contrast, these line profiles are relatively uniform during the faint periods, suggesting stable mass accretion. During the faint periods the photospheric absorption lines are absent or marginal, and the averaged Li I profile shows redshifted absorption due to an inflow. We discuss (1) occultation by circumstellar material or a companion and (2) changes in the activity of mass accretion to explain the above res...

  3. Modified viscosity in accretion disks. Application to Galactic black hole binaries, intermediate mass black holes and AGN

    CERN Document Server

    Grzędzielski, Mikołaj; Czerny, Bożena; Wu, Qingwen

    2016-01-01

    Black holes surrounded by accretion disks are present in the Universe in different scales of masses, from microquasars up to the Active Galactic Nuclei. The current picture of the accretion disk theory remains still ad hoc, due the complexity of the magnetic field action. In addition, the accretion disks at high Eddington rates can be radiation-pressure dominated and, according to some of the heating prescriptions, thermally unstable. The observational verification of their resulting variability patterns may shed the light on both the role of radiation pressure and magnetic field in the accretion process. We compute the structure and time evolution of an accretion disk. We supplement this model with a modified viscosity prescription, which can to some extent describe the magnetization of the disk. We study the results for a large grid of models and derive conclusions separately for different scales of black hole masses. We show the dependences between the flare, or outburst, duration, its amplitude and period...

  4. MITOCHONDRIA QUALITY CONTROL AND MUSCLE MASS MAINTENANCE

    Directory of Open Access Journals (Sweden)

    Vanina eRomanello

    2016-01-01

    Full Text Available Loss of muscle mass and force occurs in many diseases such as disuse/inactivity, diabetes, cancer, renal and cardiac failure and in aging-sarcopenia. In these catabolic conditions the mitochondrial content, morphology and function are greatly affected. The changes of mitochondrial network influence the production of reactive oxygen species (ROS that play an important role in muscle function. Moreover, dysfunctional mitochondria trigger catabolic signaling pathways which feed-forward to the nucleus to promote the activation of muscle atrophy. Exercise, on the other hand, improves mitochondrial function by activating mitochondrial biogenesis and mitophagy, possibly playing an important part in the beneficial effects of physical activity in several diseases. Optimised mitochondrial function is strictly maintained by the coordinated activation of different mitochondrial quality control pathways. In this review we outline the current knowledge linking mitochondria-dependent signaling pathways to muscle homeostasis in aging and disease and the resulting implications for the development of novel therapeutic approaches to prevent muscle loss.

  5. Growing massive black holes through super-critical accretion of stellar-mass seeds

    CERN Document Server

    Lupi, A; Dotti, M; Fiacconi, D; Mayer, L; Madau, P

    2015-01-01

    The rapid assembly of the massive black holes that power the luminous quasars observed at $z \\sim 6-7$ remains a puzzle. Various direct collapse models have been proposed to head-start black hole growth from initial seeds with masses $\\sim 10^5\\,\\rm M_\\odot$, which can then reach a billion solar mass while accreting at the Eddington limit. Here we propose an alternative scenario based on radiatively inefficient super-critical accretion of stellar-mass holes embedded in the gaseous circum-nuclear discs (CNDs) expected to exist in the cores of high redshift galaxies. Our sub-pc resolution hydrodynamical simulations show that stellar-mass holes orbiting within the central 100 pc of the CND bind to very high density gas clumps that arise from the fragmentation of the surrounding gas. Owing to the large reservoir of dense cold gas available, a stellar-mass black hole allowed to grow at super-Eddington rates according to the "slim disc" solution can increase its mass by 3 orders of magnitudes within a few million y...

  6. AS ABOVE, SO BELOW: EXPLOITING MASS SCALING IN BLACK HOLE ACCRETION TO BREAK DEGENERACIES IN SPECTRAL INTERPRETATION

    Energy Technology Data Exchange (ETDEWEB)

    Markoff, Sera; Silva, Catia V. [Anton Pannekoek Institute for Astronomy, University of Amsterdam, 1098 XH Amsterdam (Netherlands); Nowak, Michael A. [Massachusetts Institute of Technology, Kavli Institute for Astrophysics, Cambridge, MA 02139 (United States); Gallo, Elena; Plotkin, Richard M. [Department of Astronomy, University of Michigan, Ann Arbor, MI 48109-1042 (United States); Hynes, Robert [Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA 70803-4001 (United States); Wilms, Jörn [Dr. Karl Remeis-Sternwarte and ECAP, Universität Erlangen-Nürnberg, D-96049 Bamberg (Germany); Maitra, Dipankar [Department of Physics and Astronomy, Wheaton College, Norton, MA 02766 (United States); Drappeau, Samia, E-mail: S.B.Markoff@uva.nl, E-mail: C.V.DeJesusSilva@uva.nl, E-mail: mnowak@space.mit.edu, E-mail: egallo@umich.edu, E-mail: rih@redstick.phys.lsu.edu, E-mail: joern.wilms@sternwarte.uni-erlangen.de, E-mail: maitra_dipankar@wheatoncollege.edu, E-mail: samia.drappeau@irap.omp.eu [CNRS, IRAP, BP 44346, F-31028 Toulouse cedex 4 (France)

    2015-10-20

    Over the past decade, evidence has mounted that several aspects of black hole (BH) accretion physics proceed in a mass-invariant way. One of the best examples of this scaling is the empirical “fundamental plane of BH accretion” relation linking mass, radio, and X-ray luminosity over eight orders of magnitude in BH mass. The currently favored theoretical interpretation of this relation is that the physics governing power output in weakly accreting BHs depends more on relative accretion rate than on mass. In order to test this theory, we explore whether a mass-invariant approach can simultaneously explain the broadband spectral energy distributions from two BHs at opposite ends of the mass scale but that are at similar Eddington accretion fractions. We find that the same model, with the same value of several fitted physical parameters expressed in mass-scaling units to enforce self-similarity, can provide a good description of two data sets from V404 Cyg and M81*, a stellar and supermassive BH, respectively. Furthermore, only one of several potential emission scenarios for the X-ray band is successful, suggesting it is the dominant process driving the fundamental plane relation at this accretion rate. This approach thus holds promise for breaking current degeneracies in the interpretation of BH high-energy spectra and for constructing better prescriptions of BH accretion for use in various local and cosmological feedback applications.

  7. Theoretical Model of Non-Conservative Mass Transfer with Uniform Mass Accretion Rate in Contact Binary Stars

    Science.gov (United States)

    Gharami, Prabir; Ghosh, Koushik; Rahaman, Farook

    2016-01-01

    In contact binaries mass transfer is usually non-conservative which ends into loss of mass as well as angular momentum in the system. In the present work we have presented a new mathematical model of the non-conservative mass transfer with a uniform mass accretion rate in a contact binary system with lower angular momentum. The model has been developed under the consideration of reverse mass transfer which may occur simultaneously with the original mass transfer as a result of the large scale circulations encircling the entire donor and a significant portion of the gainer. These circulations in contact binaries with lower angular momentum are caused by the overflow of the critical equipotential surface by both the components of the binary system making the governing system more intricate and uncertain.

  8. HST measures of Mass Accretion Rates in the Orion Nebula Cluster

    CERN Document Server

    Manara, C F; Da Rio, N; Lodato, G; Hillenbrand, L A; Stassun, K G; Soderblom, D R

    2012-01-01

    The present observational understanding of the evolution of the mass accretion rates (Macc) in pre-main sequence stars is limited by the lack of accurate measurements of Macc over homogeneous and large statistical samples of young stars. Such observational effort is needed to properly constrain the theory of star formation and disk evolution. Based on HST/WFPC2 observations, we present a study of Macc for a sample of \\sim 700 sources in the Orion Nebula Cluster, ranging from the Hydrogen-burning limit to M\\ast \\sim 2M\\odot. We derive Macc from both the U-band excess and the H{\\alpha} luminosity (LH{\\alpha}), after determining empirically both the shape of the typical accretion spectrum across the Balmer jump and the relation between the accretion luminosity (Lacc) and LH{\\alpha}, that is Lacc/L\\odot = (1.31\\pm0.03)\\cdotLH{\\alpha}/L\\odot + (2.63\\pm 0.13). Given our large statistical sample, we are able to accurately investigate relations between Macc and the parameters of the central star such as mass and age....

  9. Muscle Mass and Weight Gain Nutritional Supplements

    Science.gov (United States)

    Campbell, Bill

    There are numerous sports supplements available that claim to increase lean body mass. However, for these sports supplements to exert any favorable changes in lean body mass, they must influence those factors regulating skeletal muscle hypertrophy (i.e., satellite cell activity, gene transcription, protein translation). If a given sports supplement does favorably influence one of these regulatory factors, the result is a positive net protein balance (in which protein synthesis exceeds protein breakdown). Sports supplement categories aimed at eliciting a positive net protein balance include anabolic hormone enhancers, nutrient timing pre- and postexercise workout supplements, anticatabolic supplements, and nitric oxide boosters. Of all the sports supplements available, only a few have been subject to multiple clinical trials with repeated favorable outcomes relative to increasing lean body mass. This chapter focuses on these supplements and others that have a sound theoretical rationale in relation to increasing lean body mass.

  10. Does growth hormone therapy in conjunction with resistance exercise increase muscle force production and muscle mass in men and women aged 60 years or older?

    Science.gov (United States)

    Zachwieja, J J; Yarasheski, K E

    1999-01-01

    Improved muscle protein mass and increments in maximum voluntary muscle force have rarely been observed in men and women aged 60 years and older who were treated with rhGH. Although rhGH administration has been reported to increase lean body mass in older men and women, it is doubtful that this increase is localized to skeletal muscle contractile proteins. When rhGH administration was combined with 16 weeks of resistance exercises, increases in muscle mass, muscle protein synthesis, and muscle force were not greater in the rhGH-treated group than in a weight training group that received placebo injections. Side effects of rhGH treatment in elderly people are prevalent, not trivial, and further limit its usefulness as an effective anabolic agent for promoting muscle protein accretion in men and women. In particular, the induction of insulin resistance and carpal tunnel compression reduces the efficacy of rhGH replacement therapy in elderly individuals. The evidence for a GH-induced increase in human skeletal muscle protein and maximum voluntary muscle force is weak. The optimum dose and GH-replacement paradigm (GHRH, GH-secretagogues) have not been identified. Whether rhGH therapy improves muscle protein mass and force in individuals with severe cachexia associated with major trauma, burns, surgery, or muscular dystrophy is controversial and under investigation.

  11. The Eating Habits of Milky Way Mass Halos: Destroyed Dwarf Satellites and the Metallicity Distribution of Accreted Stars

    CERN Document Server

    Deason, Alis J; Wechsler, Risa H

    2016-01-01

    We study the mass spectrum of destroyed dwarfs that contribute to the accreted stellar mass of Milky Way (MW) mass M_vir ~ 10^12.1 M_sun) halos using a suite of 45 zoom-in, dissipationless simulations. Empirical models are employed to relate (peak) subhalo mass to dwarf stellar mass, and we use constraints from z=0 observations and hydrodynamical simulations to estimate the metallicity distribution of the accreted stellar material. The dominant contributors to the accreted stellar mass are relatively massive dwarfs with M_star ~ 10^8-10^10 M_sun. Halos with more quiescent accretion histories tend to have lower mass progenitors (10^8-10^9 M_sun), and lower overall accreted stellar masses. Ultra-faint mass (M_star 10^8 M_sun can contribute a considerable fraction (~20-60 %) of metal-poor stars if their metallicity distributions have significant metal-poor tails. Finally, we find that the generic assumption of a quiescent assembly history for the MW halo seems to be in tension with the mass spectrum of its surv...

  12. Retrograde accretion discs in high-mass Be/X-ray binaries

    Science.gov (United States)

    Christodoulou, D. M.; Laycock, S. G. T.; Kazanas, D.

    2017-09-01

    We have compiled a comprehensive library of all X-ray observations of Magellanic pulsars carried out by XMM-Newton, Chandra and RXTE in the period 1997-2014. In this work, we use the data from 53 high-mass Be/X-ray binaries in the Small Magellanic Cloud to demonstrate that the distribution of spin-period derivatives versus spin periods of spinning-down pulsars is not at all different from that of the accreting spinning-up pulsars. The inescapable conclusion is that the up and down samples were drawn from the same continuous parent population; therefore, Be/X-ray pulsars that are spinning down over periods spanning 18 yr are, in fact, accreting from retrograde discs. The presence of prograde and retrograde discs in roughly equal numbers supports a new evolutionary scenario for Be/X-ray pulsars in their spin period-period derivative diagram.

  13. Spectroscopy of Low Mass X-Ray Binaries: New Insights into Accretion. Revised

    Science.gov (United States)

    DilVrtilek, Saeqa; Mushotzky, Richard (Technical Monitor)

    2001-01-01

    This project is to observe two low mass X-ray binaries, chosen for their X-ray brightness, low column density, and diversity of accretion behavior. The high spectral resolution of the RGS, the broad energy range and tremendous collecting power of EPIC, and simultaneous optical monitoring with the OM are particularly well-suited to these studies. observation of one of the two objects has taken place and the data were received in late November. The second object is yet to be observed. Over the next year we will: investigate the physical conditions of the emitting gas using emission and recombination line diagnostics to determine temperatures, densities, elemental abundances, and ionization structure; study the behavior of emission features as a function of binary orbit; and test and improve models of X-ray line emission developed by us over the past decade. We will gain insight on both the geometry of the accretion flow and on the evolutionary history of LMXBs.

  14. Spectroscopy of Low Mass X-Ray Binaries: New Insights into Accretion

    Science.gov (United States)

    Vrtilek, Saeqa Dil; Mushotzky, Richard F. (Technical Monitor)

    2002-01-01

    This project is to observe two low mass X-ray binaries, chosen for their X-ray brightness, low column density, and diversity of accretion behavior. The high spectral resolution of the RGS, the broad energy range and tremendous collecting power of EPIC, and simultaneous optical monitoring with the OM are particularly well-suited to these studies. The second of two objects was not observed until September of 2002. Data analysis for the new observation is underway. over the next year we will: investigate the physical conditions of the emitting gas using emission and recombination line diagnostics to determine temperatures, densities, elemental abundances, and ionization structure; study the behavior of emission features as a function of binary orbit; and test and improve models of X-ray line emission developed by us over the past decade. We will gain insight on both the geometry of the accretion flow and on the evolutionary history of LMXBs.

  15. Association of low muscle mass and combined low muscle mass and visceral obesity with low cardiorespiratory fitness.

    Directory of Open Access Journals (Sweden)

    Tae Nyun Kim

    Full Text Available Previous studies have shown that low cardiorespiratory fitness (CRF, visceral obesity and low muscle mass may share pathophysiological mechanisms, such as insulin resistance and chronic inflammation. In this study, we investigated whether low CRF is associated with low muscle mass, visceral obesity, and visceral obesity combined with low muscle mass.The associations between CRF and low muscle mass and combined low muscle mass and visceral obesity were examined in 298 apparently healthy adults aged 20-70 years. Low muscle mass was defined using a skeletal muscle mass index (SMI that was calculated using dual energy X-ray absorptiometry. Visceral obesity was defined as a visceral fat area (VFA exceeding 100 cm2 in women and 130 cm2 in men. We classified the participants into 4 low muscle mass/visceral obesity groups according to SMI and VFA. CRF was measured using a cycle ergometer test.CRF level correlated positively with SMI and negatively with VFA. Individuals with low muscle mass had lower CRF values than those without low muscle mass. After adjustment for age, sex, lifestyle factors, and markers for insulin resistance and inflammation, participants in the lowest quartile of CRF had an odds ratio (OR for low muscle mass of 4.98 compared with those in the highest quartile (95% confidence interval (CI = 1.19-12.99; P for trend = 0.001 and an OR for combined low muscle mass and visceral obesity of 31.46 (95% CI = 4.31-229.68; P for trend = 0.001.Individuals with lower CRF exhibited increased risk of low muscle mass and combined low muscle mass and visceral obesity. These results suggest that low CRF may be a potential indicator for low muscle mass and combined low muscle mass and visceral obesity in Korean adults.

  16. Locations of Accretion Shocks around Galaxy Clusters and the ICM properties: Insights from Self-Similar Spherical Collapse with arbitrary mass accretion rates

    CERN Document Server

    Shi, Xun

    2016-01-01

    Accretion shocks around galaxy clusters mark the position where the infalling diffuse gas is significantly slowed down, heated up, and becomes a part of the intracluster medium (ICM). They play an important role in setting the ICM properties. Hydrodynamical simulations have found an intriguing result that the radial position of this accretion shock tracks closely the position of the `splashback radius' of the dark matter, despite the very different physical processes that gas and dark matter experience. Using the self-similar spherical collapse model for dark matter and gas, we find that an alignment between the two radii happens only for a gas with an adiabatic index of $\\gamma \\approx 5/3$ and for clusters with moderate mass accretion rates. In addition, we find that some observed ICM properties, such as the entropy slope and the effective polytropic index lying around $\\sim 1.1-1.2$, are captured by the self-similar spherical collapse model, and are insensitive to the mass accretion history.

  17. Heat and mass transfer during ice accretion on aircraft wings with an improved roughness model

    Energy Technology Data Exchange (ETDEWEB)

    Fortin, Guy; Ilinca, Adrian [Groupe eolien, Universite du Quebec a Rimouski, 300 allee des Ursulines, Rimouski, PQ (Canada); Laforte, Jean-Louis [Laboratoire international des materiaux Anti-givre, Universite du Quebec a Chicoutimi, 555 Boulevard Universite, Chicoutimi, PQ (Canada)

    2006-06-15

    This paper presents the thermodynamic model used in the numerical simulation of ice accreted on an airfoil surface in wet and dry regimes developed at AMIL (Anti-Icing Materials International Laboratory), in a joint project with CIRA (Italian Aerospace Research Center). The thermodynamic model combines mass and heat balance equations to an analytical representation of water states over the airfoil to calculate the surface roughness and masses of remaining, run-back, and shedding liquid water. The water state on the surface is represented in the form of beads, film or rivulets, each situation corresponding to a particular roughness height which has a major impact on the heat transfer coefficients necessary for the heat and mass balances. The model has been tested for severe icing conditions at six different temperatures corresponding to dry, mixed and wet accretion. Water mass, roughness and heat transfer convection coefficients over the airfoil surface are presented. The thermodynamic model combined with an air flow, water trajectory, and geometric model provides accurate results. It generates the complex ice shapes observed on the wing profile, and the numerical ice shapes profiles agree well with those obtained in wind tunnel experiments. (author)

  18. A Hot and Massive Accretion Disk around the High-Mass Protostar IRAS 20126+4104

    CERN Document Server

    Chen, Huei-Ru Vivien; Zhang, Qizhou; Sridharan, T K; Liu, Sheng-Yuan; Su, Yu-Nung

    2016-01-01

    We present new spectral line observations of the CH3CN molecule in the accretion disk around the massive protostar IRAS 20126+4104 with the Submillimeter Array that for the first time measure the disk density, temperature, and rotational velocity with sufficient resolution (0.37", equivalent to ~600 AU) to assess the gravitational stability of the disk through the Toomre-Q parameter. Our observations resolve the central 2000 AU region that shows steeper velocity gradients with increasing upper state energy, indicating an increase in the rotational velocity of the hotter gas nearer the star. Such spin-up motions are characteristics of an accretion flow in a rotationally supported disk. We compare the observed data with synthetic image cubes produced by three-dimensional radiative transfer models describing a thin flared disk in Keplerian motion enveloped within the centrifugal radius of an angular-momentum-conserving accretion flow. Given a luminosity of 1.3x10^4 Lsun, the optimized model gives a disk mass of ...

  19. Mergers and mass accretion for infalling halos both end well outside cluster virial radii

    Energy Technology Data Exchange (ETDEWEB)

    Behroozi, Peter S. [Space Telescope Science Institute, Baltimore, MD 21218 (United States); Wechsler, Risa H.; Lu, Yu; Busha, Michael T. [Physics Department, Stanford University, Department of Particle and Particle Astrophysics, SLAC National Accelerator Laboratory, Kavli Institute for Particle Astrophysics and Cosmology Stanford, CA 94305 (United States); Hahn, Oliver [Institute for Astronomy, ETH Zurich, 8093-CH Zurich (Switzerland); Klypin, Anatoly [Astronomy Department, New Mexico State University, Las Cruces, NM 88003 (United States); Primack, Joel R., E-mail: behroozi@stsci.edu [Department of Physics, University of California at Santa Cruz, Santa Cruz, CA 95064 (United States)

    2014-06-01

    We find that infalling dark matter halos (i.e., the progenitors of satellite halos) begin losing mass well outside the virial radius of their eventual host halos. The peak mass occurs at a range of clustercentric distances, with median and 68th percentile range of 1.8{sub −1.0}{sup +2.3} R{sub vir,host} for progenitors of z = 0 satellites. The peak circular velocity for infalling halos occurs at significantly larger distances (3.7{sub −2.2}{sup +3.3} R{sub vir,host} at z = 0). This difference arises because different physical processes set peak circular velocity (typically, ∼1:5 and larger mergers which cause transient circular velocity spikes) and peak mass (typically, smooth accretion) for infalling halos. We find that infalling halos also stop having significant mergers well before they enter the virial radius of their eventual hosts. Mergers larger than a 1:40 ratio in halo mass end for infalling halos at similar clustercentric distances (∼1.9 R {sub vir,} {sub host}) as the end of overall mass accretion. However, mergers larger than 1:3 typically end for infalling halos at more than four virial radial away from their eventual hosts. This limits the ability of mergers to affect quenching and morphology changes in clusters. We also note that the transient spikes which set peak circular velocity may lead to issues with abundance matching on that parameter, including unphysical galaxy stellar mass growth profiles near clusters; we propose a simple observational test to check if a better halo proxy for galaxy stellar mass exists.

  20. Mergers and mass accretion for infalling halos both end well outside cluster virial radii

    Energy Technology Data Exchange (ETDEWEB)

    Behroozi, Peter S.; Wechsler, Risa H.; Lu, Yu; Hahn, Oliver; Busha, Michael T.; Klypin, Anatoly; Primack, Joel R.

    2014-05-14

    We find that infalling dark matter halos (i.e., the progenitors of satellite halos) begin losing mass well outside the virial radius of their eventual host halos. The peak mass occurs at a range of clustercentric distances, with median and 68th percentile range of $1.8^{+2.3}_{-1.0} \\,R_\\mathrm{vir,host}$ for progenitors of z = 0 satellites. The peak circular velocity for infalling halos occurs at significantly larger distances ($3.7^{+3.3}_{-2.2} \\,R_\\mathrm{vir,host}$ at z = 0). This difference arises because different physical processes set peak circular velocity (typically, ~1:5 and larger mergers which cause transient circular velocity spikes) and peak mass (typically, smooth accretion) for infalling halos. We find that infalling halos also stop having significant mergers well before they enter the virial radius of their eventual hosts. Mergers larger than a 1:40 ratio in halo mass end for infalling halos at similar clustercentric distances (~1.9 R vir, host) as the end of overall mass accretion. However, mergers larger than 1:3 typically end for infalling halos at more than four virial radial away from their eventual hosts. This limits the ability of mergers to affect quenching and morphology changes in clusters. We also note that the transient spikes which set peak circular velocity may lead to issues with abundance matching on that parameter, including unphysical galaxy stellar mass growth profiles near clusters; we propose a simple observational test to check if a better halo proxy for galaxy stellar mass exists.

  1. As above, so below: exploiting mass scaling in black hole accretion to break degeneracies in spectral interpretation

    CERN Document Server

    Markoff, Sera; Gallo, Elena; Hynes, Robert; Wilms, Jörn; Plotkin, Richard M; Maitra, Dipankar; Silva, Catia V; Drappeau, Samia

    2015-01-01

    Over the last decade, the evidence is mounting that several aspects of black hole accretion physics proceed in a mass-invariant way. One of the best examples of this scaling is the empirical "Fundamental Plane of Black Hole Accretion" relation linking mass, radio and X-ray luminosity over eight orders of magnitude in black hole mass. The currently favored theoretical interpretation of this relation is that the physics governing power output in weakly accreting black holes depends more on relative accretion rate than on mass. In order to test this theory, we explore whether a mass-invariant approach can simultaneously explain the broadband spectral energy distributions from two black holes at opposite ends of the mass scale but at similar Eddington accretion fractions. We find that the same model, with the same value of several fitted physical parameters expressed in mass-scaling units to enforce self-similarity, can provide a good description of two datasets from V404 Cyg and M81*, a stellar and supermassive ...

  2. On the possibilities of mass loss from an advective accretion disc around stationary black holes

    CERN Document Server

    Das, Santabrata; Nandi, Anuj; Sarkar, Biplob

    2014-01-01

    We study the coupled disc-jet system around the black hole where the outflow solutions are obtained in terms of the inflow parameters. We observe that an advective accretion disc can eject outflows/jets for wide range of viscosity parameter. However, such possibility is reduced if the cooling is active as the energy dissipative process inside the disc. For mass outflow, we obtain the parameter space spanned by the inflow angular momentum and the viscosity in terms of cooling and quantify the limits of viscosity parameter.

  3. The spectra of accretion discs in low-mass X-ray binaries

    CERN Document Server

    Ross, R R

    1995-01-01

    We present self-consistent models for the radiative transfer in Shakura-Sunyaev accretion discs in bright low-mass X-ray binaries (LMXB). Our calculations include the full effects of incoherent Compton scattering and the vertical temperature structure within the disc, as well as the effects of Doppler blurring and gravitational redshift. We find that the observed X-ray spectra are well fit by exponentially cutoff power-law models. The difference between the observed total spectrum and our calculated disc spectrum should reveal the spectrum of the disc/neutron star boundary layer and other emitting regions considered to be present in LMXB.

  4. VizieR Online Data Catalog: RM AGNs accretion rates and BH masses (Du+, 2016)

    Science.gov (United States)

    Du, P.; Wang, J.-M.; Hu, C.; Ho, L. C.; Li, Y.-R.; Bai, J.-M.

    2016-05-01

    We select all AGNs with reverberation mapping (RM) data (here only broad Hβ line), which yield robust BH mass estimates needed for our analysis. All RM AGNs before 2013 are summarized by Bentz et al. (2013ApJ...767..149B). Our project to search for super-Eddington accreting massive black holes (SEAMBHs) has monitored about 25 candidates and successfully measured Hβ lags ({tau}Hβ) in 14 AGNs to date (Du et al. 2015, J/ApJ/806/22) and other five objects monitored between 2014 and 2015 (to be submitted). See section 2 for further explanations. (2 data files).

  5. The jets-accretion relation, mass-luminosity relation in Fermi blazars

    CERN Document Server

    Yu, Xiaoling; Zhang, Haojing; Xiong, Dingrong; Li, Bijun; Cha, Yongjuan; Chen, Yongyun; Huang, Xia; Wang, Yuwei

    2015-01-01

    A sample of 111 Fermi blazars each with a well-established radio core luminosity, broad-line luminosity, bolometric luminosity and black hole mass has been compiled from the literatures.We present a significant correlation between radio core and broad-line emission luminosities that supports a close link between accretion processes and relativistic jets. Analysis reveals a relationship of $\\rm{LogL_{BLR}\\sim(0.81\\pm0.06)LogL_{R}^{C}}$ which is consistant with theoretical predicted coefficient and supports that blazar jets are powered by energy extraction from a rapidly spinning Kerr black hole through the magnetic field provided by the accretion disk. Through studying the correlation between the intrinsic bolometric luminosity and the black hole mass, we find a relationship of $\\rm{{Log}\\frac{L_{in}}{L_{\\odot}}=(0.95\\pm0.26){Log}\\frac{M}{M_{\\odot}}+(3.53\\pm2.24)}$ which supports mass-luminosity relation for Fermi blazars derived in this work is a powerlaw relation similar to that for main-sequence stars. Fina...

  6. Emission line diagnostics for accretion and outflows in young very low-mass stars and brown dwarfs

    Directory of Open Access Journals (Sweden)

    Stelzer B.

    2014-01-01

    Full Text Available We discuss accretion and outflow properties of three very low-mass young stellar objects based on broad-band mid-resolution X-Shooter/VLT spectra. Our targets (FU Tau A, 2M1207-39, and Par-Lup3-4 have spectral types between M5 and M8, ages between 1Myr and ~ 10Myr, and are known to be accreting from previous studies. The final objective of our project is the determination of mass outflow to accretion rate for objects near or within the substellar regime as a probe for the T Tauri phase of brown dwarfs and the investigation of variability in the accretion and outflow processes.

  7. Association between pelvic muscle mass and canine hip dysplasia.

    Science.gov (United States)

    Cardinet, G H; Kass, P H; Wallace, L J; Guffy, M M

    1997-05-15

    To investigate the relationship between pelvic muscle mass and development and expression of canine hip dysplasia (CHD). Prospective study. 5 Greyhounds with anatomically normal hip joints, 59 German Shepherd Dogs (23 with CHD, 24 with near-normal hip joints, and 12 with normal hip joints), and 18 German Shepherd Dog-Greyhound crossbreeds (7 with CHD, 6 with near-normal hip joints, and 5 with normal hip joints) between 12 and 47 months old in which pelvic muscle mass was evaluated. Pectineal muscle and hip joint development were evaluated in 25 German Shepherd Dogs at 8 and 16 or 24 weeks of age. For evaluation of pelvic muscle mass, individual pelvic muscles were weighed and hip joints were assigned a score on the basis of severity of degenerative changes. For evaluation of pectineal muscle development, muscle sections were stained and examined. Pelvic muscle mass was greatest in Greyhounds, intermediate in crossbred dogs, and smallest in German Shepherd Dogs. Differences in pelvic muscle mass among breeds were attributable to differences in weights of individual muscles. Hip score was negatively correlated with pelvic muscle mass and weights of selected pelvic muscles. Dogs with pectineal hypotrophy at 8 weeks of age had type-2 muscle fiber paucity or muscle fiber-type grouping at 16 or 24 weeks of age. At 8 weeks of age, hip joints were composed of multiple centers of ossification, and the acetabulum was largely cartilaginous. By 24 weeks of age, the pelvic bones were largely, although incompletely, fused. Diminished pelvic muscle mass in dogs with CHD and altered muscle fiber size and composition in 8-week-old dogs that subsequently develop CHD strongly suggest that abnormalities of pelvic musculature are associated with development of CHD. The complex development of the hip joint from multiple centers of ossification may make the joint susceptible to abnormal modeling forces that would result from abnormalities in pelvic muscle mass.

  8. A Spectroscopic Examination of Accretion Diagnostics for Near Solar Mass Stars in IC 348

    Science.gov (United States)

    Dahm, S. E.

    2008-08-01

    High-resolution optical and moderate-resolution near-infrared spectra were obtained for 40 near solar mass (~2.0-0.5 M sun) members of the 2-3 Myr old cluster IC 348 in order to examine established accretion diagnostics and the coupling between inner disk gas and hot, micron-sized dust grains inferred from thermal and mid-infrared excesses. The stellar sample was drawn from the cluster census of Luhman in 2003 with membership being confirmed by radial velocity analysis and the presence of strong Li I λ6708 absorption. Of the stars included in this survey, 12 were classified by Lada in 2006 as hosting primordial, optically thick circumstellar disks, 5 as weak or transition disk systems, and 23 as non-excess stars using the measured slope of the stellar spectral energy distribution (SED) through the four Infrared Array Camera channels (3.6-8.0 μm) of Spitzer Space Telescope. Using the velocity width of Hα as an accretion indicator, we find that 11 primordial disk candidates are suspected accretors, suggesting a strong correlation between gaseous inner disks and optically thick dust emission. Of the five weak or transition disk systems observed, two (L21 and L67) exhibit spectroscopic features indicative of accretion. The presence of gas within the inner disk of these systems, which are free of infrared excess emission shortward of ~4.5 μm, may place constraints upon the physical mechanism responsible for inner disk clearing. Mass accretion rates (\\dot{M}) were determined for all suspected accretors using continuum excess measurements near λ6500 and established relationships between He I λ5876, Hα, Ca II λ8542, Paβ, and Brγ line fluxes and accretion luminosity. \\dot{M} values were found to range from log \\dot{M} = -8.7 to -7.2 M sun yr-1, with a median value of -8.1 M sun yr-1. Magnetospheric accretion models of Hα, Paβ, and Brγ emission by Muzerolle et al. and Kurosawa et al. are found to be in relative agreement with observed fluxes and derived \\dot

  9. Exploring mass-scaling physics and outflow geometry in accreting black holes

    Science.gov (United States)

    Connors, Riley Michael Thomas

    2017-01-01

    One of the main tasks facing studies of black hole accretion in both black hole X-ray binaries (XRB) and Active Galactic Nuclei (AGN) is to break spectral model-fitting degeneracies. We explore two methods of simultaneous spectral modelling to reduce these degeneracies: (a) simultaneous fitting of XRBs and AGN, and (b) folding in timing properties in a novel way to better understand the outflow evolution of XRBs during outburst.It is a long-standing idea that AGN are scaled up versions of XRBs, such that the physics of accretion cares only about accretion rate, and not the black hole mass. We show that this principle of scale-invariance may provide us with a way to break degeneracies in broadband spectral modelling of both XRBs and AGN, focusing primarily on low-luminosity sources where degeneracies are more prevalent. We simultaneously model the broadband spectra of the two most quiescent (LX ~ 10-9 LEdd) accreting black holes on opposite ends of the mass scale, the XRB A0620-00 and Sgr A*, the Galactic centre supermassive black hole (during bright flaring). We use an outflow-dominated model capable of reproducing the broadband spectrum from radio to X-ray frequencies, co-evolving parameters that are representative of the mass-scaling properties. Such a method reduces the degeneracies in our model parameters, contributing to answering this question regarding the dominant emission mechanisms.We adopt a similar technique to investigate how spatial parameters of an XRB outflow can be better understood by tracking our model parameters as a function of the XRB variability properties during outburst, focusing in particular on GX 339-4. I shall discuss how utilising a novel characterisation of the timing properties of XRBs allows us to do this in a simple, quantitative way.We are currently developing our models further to incorporate the most up-to-date disc reflection routines in order to describe the jet/disc interaction more accurately. I shall briefly discuss this

  10. Do Circumnuclear Dense Gas Disks Drive Mass Accretion onto Supermassive Black Holes?

    CERN Document Server

    Izumi, Takuma; Kohno, Kotaro

    2016-01-01

    We present a positive correlation between the mass of dense molecular gas ($M_{\\rm dense}$) of $\\sim 100$ pc scale circumnuclear disks (CNDs) and the black hole mass accretion rate ($\\dot{M}_{\\rm BH}$) in total 10 Seyfert galaxies, based on data compiled from the literature and an archive (median aperture $\\theta_{\\rm med}$ = 220 pc). A typical $M_{\\rm dense}$ of CNDs is 10$^{7-8}$ $M_\\odot$, estimated from the luminosity of the dense gas tracer, the HCN($1-0$) emission line. Because dense molecular gas is the site of star formation, this correlation is virtually equivalent to the one between nuclear star formation rate and $\\dot{M}_{\\rm BH}$ revealed previously. Moreover, the $M_{\\rm dense}-\\dot{M}_{\\rm BH}$ correlation was tighter for CND-scale gas than for the gas on kpc or larger scales. This indicates that CNDs likely play an important role in fueling black holes, whereas $>$kpc scale gas does not. To demonstrate a possible approach for studying the CND-scale accretion process with the Atacama Large Mill...

  11. X-ray bursts at extreme mass accretion rates from GX 17+2

    CERN Document Server

    Kuulkers, E; Van der Klis, M; Lewin, W H G; Méndez, M

    2002-01-01

    (abridged version) We report on ten X-ray bursts from GX 17+2 in RXTE data in 1996-2000. Three bursts were short in duration (~10 s), whereas the others lasted for ~6-25 min. Five of the long bursts showed evidence for radius expansion of the neutron star photosphere. No correlations of the burst properties with respect to the persistent X-ray spectral properties are seen, suggesting no correlation with inferred persistent mass accretion rate. The presence of short bursts in GX 17+2 and other bright X-ray sources, i.e. Cyg X-2, GX 3+1 and GX 13+1, as well as the ABSENCE of bursts in the bright X-ray sources Sco X-1, GX 5-1, GX 340+0, GX 349+2, GX 9+1 and GX 9+9 is not accounted for in the current X-ray bursts theories at the high mass accretion rates encountered in these sources. We find that in contrast to previous suggestions the persistent black-body emission does NOT arise from the same site as the burst emission. The black-body component of the persistent emission is consistent with arising in an expande...

  12. Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass

    Science.gov (United States)

    Davey, Jonathan R.; Watt, Kevin I.; Parker, Benjamin L.; Chaudhuri, Rima; Ryall, James G.; Cunningham, Louise; Qian, Hongwei; Sartorelli, Vittorio; Chamberlain, Jeffrey; James, David E.

    2016-01-01

    The transforming growth factor-β (TGF-β) signaling network is a critical regulator of skeletal muscle mass and function and, thus, is an attractive therapeutic target for combating muscle disease, but the underlying mechanisms of action remain undetermined. We report that follistatin-based interventions (which modulate TGF-β network activity) can promote muscle hypertrophy that ameliorates aging-associated muscle wasting. However, the muscles of old sarcopenic mice demonstrate reduced response to follistatin compared with healthy young-adult musculature. Quantitative proteomic and transcriptomic analyses of young-adult muscles identified a transcription/translation signature elicited by follistatin exposure, which included repression of ankyrin repeat and SOCS box protein 2 (Asb2). Increasing expression of ASB2 reduced muscle mass, thereby demonstrating that Asb2 is a TGF-β network–responsive negative regulator of muscle mass. In contrast to young-adult muscles, sarcopenic muscles do not exhibit reduced ASB2 abundance with follistatin exposure. Moreover, preventing repression of ASB2 in young-adult muscles diminished follistatin-induced muscle hypertrophy. These findings provide insight into the program of transcription and translation events governing follistatin-mediated adaptation of skeletal muscle attributes and identify Asb2 as a regulator of muscle mass implicated in the potential mechanistic dysfunction between follistatin-mediated muscle growth in young and old muscles. PMID:27182554

  13. Growth of a Protostar and a Young Circumstellar Disk with High Mass Accretion Rate onto the Disk

    CERN Document Server

    Ohtani, Takuya

    2013-01-01

    The growing process of both a young protostar and a circumstellar disk is investigated. Viscous evolution of a disk around a single star is considered with a model where a disk increases its mass by dynamically accreting envelope and simultaneously loses its mass via viscous accretion onto the central star. We focus on the circumstellar disk with high mass accretion rate onto the disk $\\dot{M}=8.512c_{\\rm s}^3/G$ as a result of dynamical collapse of rotating molecular cloud core. We study the origin of the surface density distribution and the origin of the disk-to-star mass ratio by means of numerical calculations of unsteady viscous accretion disk in one-dimensional axisymmetric model. It is shown that the radial profiles of the surface density $\\Sigma$, azimuthal velocity $v_{\\phi}$, and mass accretion rate $\\dot{M}$ in the inner region approach to the quasi-steady state. Profile of the surface density distribution in the quasi-steady state is determined as a result of angular momentum transport rather than...

  14. Detecting Both the Mass and Position of an Accreted Particle by a Micro/Nano-Mechanical Resonator Sensor

    Directory of Open Access Journals (Sweden)

    Yin Zhang

    2014-09-01

    Full Text Available In the application of a micro-/nano-mechanical resonator, the position of an accreted particle and the resonant frequencies are measured by two different physical systems. Detecting the particle position sometimes can be extremely difficult or even impossible, especially when the particle is as small as an atom or a molecule. Using the resonant frequencies to determine the mass and position of an accreted particle formulates an inverse problem. The Dirac delta function and Galerkin method are used to model and formulate an eigenvalue problem of a beam with an accreted particle. An approximate method is proposed by ignoring the off-diagonal elements of the eigenvalue matrix. Based on the approximate method, the mass and position of an accreted particle can be decoupled and uniquely determined by measuring at most three resonant frequencies. The approximate method is demonstrated to be very accurate when the particle mass is small, which is the application scenario for much of the mass sensing of micro-/nano-mechanical  resonators. By solving the inverse problem,  the position measurement becomes unnecessary, which is of some help to the mass sensing application  of a micro-/nano-mechanical resonator by reducing two measurement systems to one. How to apply the method to the general scenario of multiple accreted particles is also discussed.

  15. Detecting both the mass and position of an accreted particle by a micro/nano-mechanical resonator sensor.

    Science.gov (United States)

    Zhang, Yin; Liu, Yun

    2014-09-02

    In the application of a micro-/nano-mechanical resonator, the position of an accreted particle and the resonant frequencies are measured by two different physical systems. Detecting the particle position sometimes can be extremely difficult or even impossible, especially when the particle is as small as an atom or a molecule. Using the resonant frequencies to determine the mass and position of an accreted particle formulates an inverse problem. The Dirac delta function and Galerkin method are used to model and formulate an eigenvalue problem of a beam with an accreted particle. An approximate method is proposed by ignoring the off-diagonal elements of the eigenvalue matrix. Based on the approximate method, the mass and position of an accreted particle can be decoupled and uniquely determined by measuring at most three resonant frequencies. The approximate method is demonstrated to be very accurate when the particle mass is small, which is the application scenario for much of the mass sensing of micro-/nano-mechanical  resonators. By solving the inverse problem,  the position measurement becomes unnecessary, which is of some help to the mass sensing application  of a micro-/nano-mechanical resonator by reducing two measurement systems to one. How to apply the method to the general scenario of multiple accreted particles is also discussed.

  16. Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons

    NARCIS (Netherlands)

    Visser, M.; Goodpaster, B.H.; Kritchevsky, S.B.; Newman, A.B.; Nevitt, M.C.; Rubin, S.M.; Simonsick, E.M.; Harris, T.B.

    2005-01-01

    .05). Among men and women, associations were similar for blacks and whites. CONCLUSION: Lower muscle mass (smaller cross-sectional thigh muscle area), greater fat infiltration into the muscle, and lower knee extensor muscle strength are associated with increased risk of mobility loss in older men

  17. Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons

    NARCIS (Netherlands)

    Visser, M.; Goodpaster, B.H.; Kritchevsky, S.B.; Newman, A.B.; Nevitt, M.C.; Rubin, S.M.; Simonsick, E.M.; Harris, T.B.

    2005-01-01

    .05). Among men and women, associations were similar for blacks and whites. CONCLUSION: Lower muscle mass (smaller cross-sectional thigh muscle area), greater fat infiltration into the muscle, and lower knee extensor muscle strength are associated with increased risk of mobility loss in older men an

  18. Eddington-limited accretion and the black hole mass function at redshift 6

    CERN Document Server

    Willott, Chris J; Arzoumanian, Doris; Bergeron, Jacqueline; Crampton, David; Delorme, Philippe; Hutchings, John B; Omont, Alain; Reyle, Celine; Schade, David

    2010-01-01

    We present discovery observations of a quasar in the Canada-France High-z Quasar Survey (CFHQS) at redshift z=6.44. We also use near-IR spectroscopy of nine CFHQS quasars at z~6 to determine black hole masses. These are compared with similar estimates for more luminous Sloan Digital Sky Survey (SDSS) quasars to investigate the relationship between black hole mass and quasar luminosity. We find a strong correlation between MgII FWHM and UV luminosity and that most quasars at this early epoch are accreting close to the Eddington limit. Thus these quasars appear to be in an early stage of their life cycle where they are building up their black hole mass exponentially. Combining these results with the quasar luminosity function, we derive the black hole mass function at z=6. Our black hole mass function is ~10^4 times lower than at z=0 and substantially below estimates from previous studies. The main uncertainties which could increase the black hole mass function are a larger population of obscured quasars at hig...

  19. Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men.

    Science.gov (United States)

    Pennings, Bart; Groen, Bart; de Lange, Anneke; Gijsen, Annemie P; Zorenc, Antoine H; Senden, Joan M G; van Loon, Luc J C

    2012-04-15

    Whey protein ingestion has been shown to effectively stimulate postprandial muscle protein accretion in older adults. However, the impact of the amount of whey protein ingested on protein digestion and absorption kinetics, whole body protein balance, and postprandial muscle protein accretion remains to be established. We aimed to fill this gap by including 33 healthy, older men (73 ± 2 yr) who were randomly assigned to ingest 10, 20, or 35 g of intrinsically l-[1-¹³C]phenylalanine-labeled whey protein (n = 11/treatment). Ingestion of labeled whey protein was combined with continuous intravenous l-[ring-²H₅]phenylalanine and l-[ring-²H₂]tyrosine infusion to assess the metabolic fate of whey protein-derived amino acids. Dietary protein digestion and absorption rapidly increased following ingestion of 10, 20, and 35 g whey protein, with the lowest and highest (peak) values observed following 10 and 35 g, respectively (P whey protein results in greater amino acid absorption and subsequent stimulation of de novo muscle protein synthesis compared with the ingestion of 10 or 20 g whey protein in healthy, older men.

  20. Hydrogen-Accreting Carbon-Oxygen White Dwarfs of Low Mass Thermal and Chemical Behavior of Burning Shells

    CERN Document Server

    Piersanti, L; Iben, I; Tornambé, A

    2000-01-01

    Numerical experiments have been performed to investigate the thermal behavior of a cooled down white dwarf of initial mass $M_{\\rm WD} = 0.516 M_{\\sun}$ which accretes hydrogen-rich matter with Z = 0.02 at the rate $\\dot{M}=10^{-8}$ \\msun \\yrm1, typical for a recurrent hydrogen shell flash regime. The evolution of the main physical quantities of a model during a pulse cycle is examined in detail. From selected models in the mass range $M_{\\rm WD} = 0.52\\div 0.68$ \\msunend, we derive the borders in the $M_{\\rm WD}$ - $\\dot{M}$ plane of the steady state accretion regime when hydrogen is burned at a constant rate as rapidly as it is accreted. The physical properties during a hydrogen shell flash in white dwarfs accreting hydrogen-rich matter with metallicities Z = 0.001 and Z = 0.0001 are also studied. For a fixed accretion rate, a decrease in the metallicity of the accreted matter leads to an increase in the thickness of the hydrogen-rich layer at outburst and a decrease in the hydrogen-burning shell efficiency...

  1. An ALMA Constraint on the GSC 6214-210 B Circum-Substellar Accretion Disk Mass

    CERN Document Server

    Bowler, Brendan P; Kraus, Adam L; Ireland, Michael J; Herczeg, Gregory; Ricci, Luca; Carpenter, John; Brown, Michael E

    2015-01-01

    We present Atacama Large Millimeter/submillimeter Array (ALMA) observations of GSC 6214-210 A and B, a solar-mass member of the 5-10 Myr Upper Scorpius association with a 15 $\\pm$ 2 Mjup companion orbiting at $\\approx$330 AU (2.2"). Previous photometry and spectroscopy spanning 0.3-5 $\\mu$m revealed optical and thermal excess as well as strong H$\\alpha$ and Pa~$\\beta$ emission originating from a circum-substellar accretion disk around GSC 6214-210 B, making it the lowest mass companion with unambiguous evidence of a subdisk. Despite ALMA's unprecedented sensitivity and angular resolution, neither component was detected in our 880 $\\mu$m (341 GHz) continuum observations down to a 3-$\\sigma$ limit of 0.22 mJy/beam. The corresponding constraints on the dust mass and total mass are <0.15 Mearth and <0.05 Mjup, respectively, or <0.003% and <0.3% of the mass of GSC 6214-210 B itself assuming a 100:1 gas-to-dust ratio and characteristic dust temperature of 10-20 K. If the host star possesses a putative c...

  2. A transition in circumbinary accretion discs at a binary mass ratio of 1:25

    Science.gov (United States)

    D'Orazio, Daniel J.; Haiman, Zoltán; Duffell, Paul; MacFadyen, Andrew; Farris, Brian

    2016-07-01

    We study circumbinary accretion discs in the framework of the restricted three-body problem (R3Bp) and via numerically solving the height-integrated equations of viscous hydrodynamics. Varying the mass ratio of the binary, we find a pronounced change in the behaviour of the disc near mass ratio q ≡ Ms/Mp ˜ 0.04. For mass ratios above q = 0.04, solutions for the hydrodynamic flow transition from steady, to strongly fluctuating; a narrow annular gap in the surface density around the secondary's orbit changes to a hollow central cavity; and a spatial symmetry is lost, resulting in a lopsided disc. This phase transition is coincident with the mass ratio above which stable orbits do not exist around the L4 and L5 equilibrium points of the R3Bp. Using the DISCO code, we find that for thin discs, for which a gap or cavity can remain open, the mass ratio of the transition is relatively insensitive to disc viscosity and pressure. The q = 0.04 transition has relevance for the evolution of massive black hole binary+disc systems at the centres of galactic nuclei, as well as for young stellar binaries and possibly planets around brown dwarfs.

  3. A transition in circumbinary accretion discs at a binary mass ratio of 1:25

    CERN Document Server

    D'Orazio, Daniel J; Duffell, Paul; MacFadyen, Andrew I; Farris, Brian D

    2015-01-01

    We study circumbinary accretion discs in the framework of the restricted three-body problem (R3Bp) and via numerically solving the height-integrated equations of viscous hydrodynamics. Varying the mass ratio of the binary, we find a pronounced change in the behaviour of the disc near mass ratio $q \\equiv M_s/M_p \\sim 0.04$. For mass ratios above $q=0.04$, solutions for the hydrodynamic flow transition from steady, to strongly-fluctuating; a narrow annular gap in the surface density around the secondary's orbit changes to a hollow central cavity; and a spatial symmetry is lost, resulting in a lopsided disc. This phase transition is coincident with the mass ratio above which stable orbits do not exist around the L4 and L5 equilibrium points of the R3B problem. Using the DISCO code, we find that for thin discs, for which a gap or cavity can remain open, the mass ratio of the transition is relatively insensitive to disc viscosity and pressure. The $q=0.04$ transition has relevance for the evolution of massive bla...

  4. Modified viscosity in accretion disks. Application to Galactic black hole binaries, intermediate mass black holes, and active galactic nuclei

    Science.gov (United States)

    Grzędzielski, Mikołaj; Janiuk, Agnieszka; Czerny, Bożena; Wu, Qingwen

    2017-07-01

    Aims: Black holes (BHs) surrounded by accretion disks are present in the Universe at different scales of masses, from microquasars up to the active galactic nuclei (AGNs). Since the work of Shakura & Sunyaev (1973, A&A, 24, 337) and their α-disk model, various prescriptions for the heat-production rate are used to describe the accretion process. The current picture remains ad hoc due the complexity of the magnetic field action. In addition, accretion disks at high Eddington rates can be radiation-pressure dominated and, according to some of the heating prescriptions, thermally unstable. The observational verification of their resulting variability patterns may shed light on both the role of radiation pressure and magnetic fields in the accretion process. Methods: We compute the structure and time evolution of an accretion disk, using the code GLADIS (which models the global accretion disk instability). We supplement this model with a modified viscosity prescription, which can to some extent describe the magnetisation of the disk. We study the results for a large grid of models, to cover the whole parameter space, and we derive conclusions separately for different scales of black hole masses, which are characteristic for various types of cosmic sources. We show the dependencies between the flare or outburst duration, its amplitude, and period, on the accretion rate and viscosity scaling. Results: We present the results for the three grids of models, designed for different black hole systems (X-ray binaries, intermediate mass black holes, and galaxy centres). We show that if the heating rate in the accretion disk grows more rapidly with the total pressure and temperature, the instability results in longer and sharper flares. In general, we confirm that the disks around the supermassive black holes are more radiation-pressure dominated and present relatively brighter bursts. Our method can also be used as an independent tool for the black hole mass determination

  5. Growth of Jupiter: Enhancement of Core Accretion by a Voluminous Low-Mass Envelope

    CERN Document Server

    D'Angelo, Gennaro; Lissauer, Jack J; Bodenheimer, Peter

    2014-01-01

    We present calculations of the early stages of the formation of Jupiter via core nucleated accretion and gas capture. The core begins as a seed body of about 350 kilometers in radius and orbits in a swarm of planetesimals whose initial radii range from 15 meters to 50 kilometers. The evolution of the swarm accounts for growth and fragmentation, viscous and gravitational stirring, and for drag-assisted migration and velocity damping. During this evolution, less than 9% of the mass is in planetesimals smaller than 1 kilometer in radius; < ~25% is in planetesimals with radii between 1 and 10 kilometers; and < ~7% is in bodies with radii larger than 100 kilometers. Gas capture by the core substantially enhances the size-dependent cross-section of the planet for accretion of planetesimals. The calculation of dust opacity in the planet's envelope accounts for coagulation and sedimentation of dust particles released as planetesimals are ablated. The calculation is carried out at an orbital semi-major axis of 5...

  6. THE EATING HABITS OF MILKY WAY-MASS HALOS: DESTROYED DWARF SATELLITES AND THE METALLICITY DISTRIBUTION OF ACCRETED STARS

    Energy Technology Data Exchange (ETDEWEB)

    Deason, Alis J.; Mao, Yao-Yuan; Wechsler, Risa H., E-mail: adeason@stanford.edu [Kavli Institute for Particle Astrophysics and Cosmology and Physics Department, Stanford University, Stanford, CA 94305 (United States)

    2016-04-10

    We study the mass spectrum of destroyed dwarfs that contribute to the accreted stellar mass of Milky Way (MW)-mass (M{sub vir} ∼ 10{sup 12.1} M{sub ⊙}) halos using a suite of 45 zoom-in dissipationless simulations. Empirical models are employed to relate (peak) subhalo mass to dwarf stellar mass, and we use constraints from z = 0 observations and hydrodynamical simulations to estimate the metallicity distribution of the accreted stellar material. The dominant contributors to the accreted stellar mass are relatively massive dwarfs with M{sub star} ∼ 10{sup 8}–10{sup 10}M{sub ⊙}. Halos with more quiescent accretion histories tend to have lower mass progenitors (10{sup 8}–10{sup 9} M{sub ⊙}), and lower overall accreted stellar masses. Ultra-faint mass (M{sub star} < 10{sup 5} M{sub ⊙}) dwarfs contribute a negligible amount (≪1%) to the accreted stellar mass and, despite having low average metallicities, supply a small fraction (∼2%–5%) of the very metal-poor stars with [Fe/H] < −2. Dwarfs with masses 10{sup 5} < M{sub star}/M{sub ⊙} < 10{sup 8} provide a substantial amount of the very metal-poor stellar material (∼40%–80%), and even relatively metal-rich dwarfs with M{sub star} > 10{sup 8} M{sub ⊙} can contribute a considerable fraction (∼20%–60%) of metal-poor stars if their metallicity distributions have significant metal-poor tails. Finally, we find that the generic assumption of a quiescent assembly history for the MW halo seems to be in tension with the mass spectrum of its surviving dwarfs. We suggest that the MW could be a “transient fossil”; a quiescent halo with a recent accretion event(s) that disguises the preceding formation history of the halo.

  7. CORRELATIONS BETWEEN MUSCLE MASS, MUSCLE STRENGTH, PHYSICAL PERFORMANCE, AND MUSCLE FATIGUE RESISTANCE IN COMMUNITY-DWELLING ELDERLY SUBJECTS

    Directory of Open Access Journals (Sweden)

    Elizabeth

    2016-03-01

    Full Text Available Objective: To determine the correlations between muscle mass, muscle strength, physical performance, and muscle fatigue resistance in community-dwelling elderly people in order to elucidate factors which contribute to elderly’s performance of daily activities. Methods: A cross-sectional study was conducted on community-dwelling elderly in Bandung from September to December 2014. One hundred and thirty elderly, 60 years old or above, were evaluated using bioelectrical impedance analysis to measure muscle mass; grip strength to measure muscle strength and muscle fatigue resistance; habitual gait speed to measure physical performance; and Global Physical Activity Questionnaire (GPAQ to assess physical activity. Results: There were significant positive correlations between muscle mass (r=0,27, p=0,0019, muscle strength (r=0,26, p=0,0024, and physical performance (r=0,32, p=0,0002 with muscle fatigue resistance. Physical performance has the highest correlation based on multiple regression test (p=0,0025. In association with muscle mass, the physical activity showed a significant positive correlation (r=0,42, p=0,0000. Sarcopenia was identified in 19 (14.61% of 130 subjects. Conclusions: It is suggested that muscle mass, muscle strength, and physical performance influence muscle fatigue resistance.

  8. Effect of transcutaneous electrical muscle stimulation on postoperative muscle mass and protein synthesis

    DEFF Research Database (Denmark)

    Vinge, O; Edvardsen, L; Jensen, F

    1996-01-01

    In an experimental study, 13 patients undergoing major elective abdominal surgery were given postoperative transcutaneous electrical muscle stimulation (TEMS) to the quadriceps femoris muscle on one leg; the opposite leg served as control. Changes in cross-sectional area (CSA) and muscle protein...... muscle protein synthesis and muscle mass after abdominal surgery and should be evaluated in other catabolic states with muscle wasting....... synthesis were assessed by computed tomography and ribosome analysis of percutaneous muscle biopsies before surgery and on the sixth postoperative day. The percentage of polyribosomes in the ribosome suspension decreased significantly (P

  9. Muscle Strength, Muscle Mass, and Physical Disability in Women with Systemic Lupus Erythematosus

    Science.gov (United States)

    Andrews, James S.; Trupin, Laura; Schmajuk, Gabriela; Barton, Jennifer; Margaretten, Mary; Yazdany, Jinoos; Yelin, Edward H.; Katz, Patricia P.

    2014-01-01

    Objective Limited data exist describing relationships between muscle strength, muscle mass, and physical disability among individuals with systemic lupus erythematosus (SLE). The present study examines the relationship of muscle strength and muscle mass with physical disability among adult women with SLE. Methods One hundred forty-six women from a longitudinal SLE cohort participated in the study. All measures were collected during an in-person research visit. Lower extremity muscle strength was assessed by peak knee torque of extension and flexion and by chair-stand time. Total lean body mass, appendicular lean mass, and fat mass (kg/m2) were measured by whole-body dual energy absorptiometry. Self-reported physical disability was assessed using the SF-36 Physical Functioning subscale and Valued Life Activities (VLA) Disability scale. Spearman’s rank correlation coefficients tested the correlations between muscle strength, muscle mass, and disability scores. Regression analyses modeled the effect of lower extremity muscle strength and mass on SF-36 and VLA disability scores controlling for age, SLE duration, SLE disease activity measured with the Systemic Lupus Activity Questionnaire (SLAQ), physical activity level, prednisone use, body composition, and depression. Results On all measures, reduced lower extremity muscle strength was associated with poorer SF-36 and VLA disability scores. Trends persisted after adjustment for covariates. Muscle mass was moderately correlated with muscle strength, but did not contribute significantly to adjusted regression models. Conclusions Lower extremity muscle strength, but not muscle mass, was strongly associated with physical disability scores. While further studies are needed, these findings suggest that improving muscle strength may reduce physical disability among women with SLE. PMID:25049114

  10. Mass accretion rates from multi-band photometry in the Carina Nebula: the case of Trumpler 14

    CERN Document Server

    Beccari, G; Panagia, N; Valenti, E; Carraro, G; Romaniello, M; Zoccali, M; Weidner, C

    2014-01-01

    We present a study of the mass accretion rates of pre-Main Sequence (PMS) stars in the cluster Trumpler 14 (Tr14) in the Carina Nebula. Using optical multi-band photometry we were able to identify 356 PMS stars showing H-alpha excess emission with equivalent width EW(H-alpha)>20\\AA. We interpret this observational feature as indication that these objects are still actively accreting gas from their circumstellar medium. From a comparison of the HR diagram with PMS evolutionary models we derive ages and masses of the PMS stars. We find that most of the PMS objects are younger than 10 Myr with a median age of ~3 Myr. Surprisingly, we also find that ~20% of the mass accreting objects are older than 10 Myr. For each PMS star in Trumpler 14 we determine the mass accretion rate ($\\dot{M}_{acc}$) and discuss its dependence on mass and age. We finally combine the optical photometry with near-IR observations to build the spectral energy distribution (SED) for each PMS star in Tr14. The analysis of the SEDs suggests the...

  11. The low-mass stellar population in the young cluster Tr37: Disk evolution, accretion, and environment

    CERN Document Server

    Sicilia-Aguilar, Aurora; Sobolev, Andrej; Getman, Konstantin; Henning, Thomas; Fang, Min

    2013-01-01

    We present a study of accretion and protoplanetary disks around M-type stars in the 4 Myr-old cluster Tr37. With a well-studied solar-type population, Tr37 is a benchmark for disk evolution. We used low-resolution spectroscopy to identify 141 members (78 new) and 64 probable members, mostly M-type stars. H\\alpha\\ emission provides information about accretion. Optical, 2MASS, Spitzer, and WISE data are used to trace the SEDs. We construct radiative transfer models to explore the structures of full-disks, pre-transition, transition, and dust-depleted disks. Including the new and previously known members, we confirm that a substantial fraction (~2/5) of disks show signs of evolution, either as radial dust evolution (transition/pre-transition disks) or as a more global evolution (low small-dust masses, dust settling, and weak/absent accretion signatures). Accretion is strongly dependent on the SED type. About half of the transition objects are consistent with no accretion, and dust-depleted disks have weak (or un...

  12. The Observed Galactic Annihilation Line. Possible Signature of the Cluster for Accreting Small Mass Black Holes

    CERN Document Server

    Titarchuk, L; Titarchuk, Lev; Chardonnet, Pascal

    2006-01-01

    Compton Gamma Ray Observatory, OSSE, SMM, TGRS, balloon and recent INTEGRAL data reveal a feature of the 0.511 MeV annihilation radiation of the Galactic Center with a flux of approximately 5x 10^{-4}~0.511 MeV photons cm^{-2} s^{-1}. We argue that e+e- pairs can be generated when the X-ray radiation photons and ~10-30 MeV photons interact with each other in the compact region in the proximity of the Galactic Center black hole. In fact, disks formed near black holes of 10^{17} g mass should emit the ~ 10 MeV temperature blackbody radiation. If positron e+ sources are producing about 10^{42} e+ s^{-1} near the Galactic Center they would annihilate on the way out and result in 0.511 MeV emission. We suggest that the annihilation radiation can be an observational consequence of the interaction of the accretion disk radiation of the SMall Mass Black Holes (SMMBHs) with X-ray radiation in the Galactic Center. This is probably the only way to identify and observe these SMMBHs.

  13. Burst-properties as a function of mass accretion rate in GX 3+1

    CERN Document Server

    Den Hartog, P; Kuulkers, E; Cornelisse, R; Heisse, J; Bazzano, A; Cocchi, M; Natalucci, L; Ubertini, P

    2003-01-01

    GX 3+1 is a low-mass X-ray binary that is persistently bright since its discovery in 1964. It was found to be an X-ray burster twenty years ago proving that the compact object in this system is a neutron star. The burst rate is so low that only 18 bursts were reported prior to 1996. The Wide Field Cameras on BeppoSAX have, through a dedicated monitoring program on the Galactic center region, increased the number of X-ray bursts from GX 3+1 by 61. Since GX 3+1 exhibits a slow (order of years) modulation in the persistent flux of about 50%, these observations opens up the unique possibility to study burst properties as a function of mass accretion rate for very low burst rates. This is the first time that bursts are detected from GX 3+1 in the high state. From the analysis we learn that all bursts are short with e-folding decay times smaller than 10 s. Therefore, all bursts are due to unstable helium burning. Furthermore, the burst rate drops sixfold in a fairly narrow range of 2-20 keV flux; we discuss possibl...

  14. System mass constraints for the accreting millisecond pulsar XTE J1814-338 using Bowen fluorescence

    Science.gov (United States)

    Wang, L.; Steeghs, D.; Casares, J.; Charles, P. A.; Muñoz-Darias, T.; Marsh, T. R.; Hynes, R. I.; O'Brien, K.

    2017-04-01

    We present phase-resolved spectroscopy of the millisecond X-ray pulsar XTE J1814-338 obtained during its 2003 outburst. The spectra are dominated by high-excitation emission lines of He II λ4686, Hβ, and the Bowen blend C III/N III 4630-50 Å. We exploit the proven Bowen fluorescence technique to establish a complete set of dynamical system parameter constraints using bootstrap Doppler tomography, a first for an accreting millisecond X-ray pulsar binary. The reconstructed Doppler map of the N III λ4640 Bowen transition exhibits a statistically significant (>4σ) spot feature at the expected position of the companion star. If this feature is driven by irradiation of the surface of the Roche lobe filling companion, we derive a strict lower limit to the true radial velocity semi-amplitude K2. Combining our donor constraint with the well-constrained orbit of the neutron star leads to a determination of the binary mass ratio: q = 0.123^{+0.012}_{-0.010}. The component masses are not tightly constrained given our lack of knowledge of the binary inclination. We cannot rule out a canonical neutron star mass of 1.4 M⊙ (1.1 M⊙ confidence limits of M2 are consistent with the companion being a significantly bloated, M-type main-sequence star. Our findings, combined with results from studies of the quiescent optical counterpart of XTE J1814-338, suggest the presence of a rotation-powered millisecond pulsar in XTE J1814-338 during an X-ray quiescent state. The companion mass is typical of the so-called redback pulsar binary systems (M2 ˜ 0.2 M⊙).

  15. The Role for the Inner Disk in Mass Accretion to the Star in the Early Phase of Star Formation

    CERN Document Server

    Ohtani, Takuya; Tsuribe, Toru; Vorobyov, Eduard I

    2014-01-01

    A physical mechanism that drives FU Orionis-type outbursts is reconsidered. We study the effect of inner part of a circumstellar disk covering a region from near the central star to the radius of approximately $5$ AU (hereafter, the inner disk). Using the fluctuated mass accretion rate onto the inner disk $\\dot{M}_{\\rm out}$, we consider the viscous evolution of the inner disk and the time variability of the mass accretion rate onto the central star $\\dot{M}_{\\rm in}$ by means of numerical calculation of an unsteady viscous accretion disk in a one-dimensional axisymmetric model. First, we calculate the evolution of the inner disk assuming an oscillating $\\dot{M}_{\\rm out}$. It is shown that the time variability of $\\dot{M}_{\\rm in}$ does not coincide with $\\dot{M}_{\\rm out}$ due to viscous diffusion. Second, we investigate the properties of spontaneous outbursts with temporally constant $\\dot{M}_{\\rm out}$. Outburst occur only in a limited range of mass accretion rates onto the inner disk $10^{-10}<\\dot{M}...

  16. Regulation of Muscle Mass by Follistatin and Activins

    Science.gov (United States)

    Lee, Se-Jin; Lee, Yun-Sil; Zimmers, Teresa A.; Soleimani, Arshia; Matzuk, Martin M.; Tsuchida, Kunihiro; Cohn, Ronald D.; Barton, Elisabeth R.

    2010-01-01

    Myostatin is a TGF-β family member that normally acts to limit skeletal muscle mass. Follistatin is a myostatin-binding protein that can inhibit myostatin activity in vitro and promote muscle growth in vivo. Mice homozygous for a mutation in the Fst gene have been shown to die immediately after birth but have a reduced amount of muscle tissue, consistent with a role for follistatin in regulating myogenesis. Here, we show that Fst mutant mice exhibit haploinsufficiency, with muscles of Fst heterozygotes having significantly reduced size, a shift toward more oxidative fiber types, an impairment of muscle remodeling in response to cardiotoxin-induced injury, and a reduction in tetanic force production yet a maintenance of specific force. We show that the effect of heterozygous loss of Fst is at least partially retained in a Mstn-null background, implying that follistatin normally acts to inhibit other TGF-β family members in addition to myostatin to regulate muscle size. Finally, we present genetic evidence suggesting that activin A may be one of the ligands that is regulated by follistatin and that functions with myostatin to limit muscle mass. These findings potentially have important implications with respect to the development of therapeutics targeting this signaling pathway to preserve muscle mass and prevent muscle atrophy in a variety of inherited and acquired forms of muscle degeneration. PMID:20810712

  17. Measuring Mass Accretion Rate onto the Supermassive Black Hole in M 87 Using Faraday Rotation Measure with the Submillimeter Array

    CERN Document Server

    Kuo, C Y; Rao, R; Nakamura, M; Algaba, J C; Liu, H B; Inoue, M; Koch, P M; Ho, P T P; Matsushita, S; Pu, H -Y; Akiyama, K; Nishioka, H; Pradel, N

    2014-01-01

    We present the first constraint on Faraday rotation measure (RM) at submillimeter wavelengths for the nucleus of M 87. By fitting the polarization position angles ($\\chi$) observed with the SMA at four independent frequencies around $\\sim$230 GHz and interpreting the change in $\\chi$ as a result of \\emph{external} Faraday rotation associated with accretion flow, we determine the rotation measure of the M 87 core to be between $-$7.5$\\times$10$^{5}$ and 3.4$\\times$10$^{5}$ rad/m$^{2}$. Assuming a density profile of the accretion flow that follows a power-law distribution and a magnetic field that is ordered, radial, and has equipartition strength, the limit on the rotation measure constrains the mass accretion rate $\\dot{M}$ to be below 9.2$\\times$10$^{-4}$ M$_{\\odot}$~yr$^{-1}$ at a distance of 21 Schwarzchild radii from the central black hole. This value is at least two orders of magnitude smaller than the Bondi accretion rate, suggesting significant suppression of the accretion rate in the inner region of t...

  18. Mass retention efficiency and i-process nucleosynthesis in He-shell flash evolution of rapidly accreting white dwarfs

    CERN Document Server

    Denissenkov, Pavel; Battino, Umberto; Ritter, Christian; Pignatari, Marco; Jones, Samuel; Paxton, Bill

    2016-01-01

    Based on stellar evolution simulations, we demonstrate that rapidly accreting white dwarfs (RAWDs) in close binary systems, like those considered in the single-degenerate progenitor channel of type Ia supernovae, experience recurrent and very strong He-shell flashes in the stable H-burning accretion regime. The He-shell flashes result in the expansion and, utimately, ejection of the newly-accreted material via super-Eddington luminosity winds or Roche-lobe overflow. The white dwarf models do not retain any significant amount of the accreted mass, with a He retention efficiency of < 10% depending on mass and convective boundary mixing assumptions. This makes the evolutionary path of such systems to supernova Ia explosion highly unlikely. Instead, we have discovered that such binary systems are an astrophysical site for the intermediate neutron-capture process. In each of the He-shell flashes H-rich material enters the He-shell flash convection zone. 1D stellar evolution simulations of RAWDs show the H-inges...

  19. Associations of Sarcopenia and Sarcopenic Obesity With Metabolic Syndrome Considering Both Muscle Mass and Muscle Strength

    Science.gov (United States)

    2016-01-01

    Objectives: We investigated the associations of sarcopenia-defined both in terms of muscle mass and muscle strength-and sarcopenic obesity with metabolic syndrome. Methods: Secondary data pertaining to 309 subjects (85 men and 224 women) were collected from participants in exercise programs at a health center in a suburban area. Muscle mass was measured using bioelectrical impedance analysis, and muscle strength was measured via handgrip strength. Sarcopenia based on muscle mass alone was defined as a weight-adjusted skeletal muscle mass index more than two standard deviations below the mean of a sex-specific young reference group (class II sarcopenia). Two cut-off values for low handgrip strength were used: the first criteria were sarcopenia and being in the two highest quintiles of total body fat percentage among the subjects. The associations of sarcopenia and sarcopenic obesity with metabolic syndrome were evaluated using logistic regression models. Results: The age-adjusted risk ratios (RRs) of metabolic syndrome being compared in people with or without sarcopenia defined in terms of muscle mass were 1.25 (95% confidence interval [CI], 1.06 to 1.47, p=0.008) in men and 1.12 (95% CI, 1.06 to 1.19, psarcopenia defined in terms of muscle mass and sarcopenic obesity with metabolic syndrome were statistically significant in both men and women. Therefore, sarcopenia and sarcopenic obesity must be considered as part of the community-based management of non-communicable diseases. PMID:26841883

  20. Accreting Neutron Stars in Low-Mass X-Ray Binary Systems

    CERN Document Server

    Lamb, Frederick K

    2007-01-01

    Using the Rossi X-ray Timing Explorer (RossiXTE), astronomers have discovered that disk-accreting neutron stars with weak magnetic fields produce three distinct types of high-frequency X-ray oscillations. These oscillations are powered by release of the binding energy of matter falling into the strong gravitational field of the star or by the sudden nuclear burning of matter that has accumulated in the outermost layers of the star. The frequencies of the oscillations reflect the orbital frequencies of gas deep in the gravitational field of the star and/or the spin frequency of the star. These oscillations can therefore be used to explore fundamental physics, such as strong-field gravity and the properties of matter under extreme conditions, and important astrophysical questions, such as the formation and evolution of millisecond pulsars. Observations using RossiXTE have shown that some two dozen neutron stars in low-mass X-ray binary systems have the spin rates and magnetic fields required to become milliseco...

  1. Investigating accretion disk - radio jet coupling across the stellar mass scale

    CERN Document Server

    Miller-Jones, James C A; Altamirano, Diego; Körding, Elmar G; Krimm, Hans A; Maitra, Dipankar; Remillard, Ron A; Russell, David M; Tudose, Valeriu; Dhawan, Vivek; Fender, Rob P; Heinz, Sebastian; Markoff, Sera; Migliari, Simone; Rupen, Michael P; Sarazin, Craig L

    2010-01-01

    Relationships between the X-ray and radio behavior of black hole X-ray binaries during outbursts have established a fundamental coupling between the accretion disks and radio jets in these systems. We begin by reviewing the prevailing paradigm for this disk-jet coupling, also highlighting what we know about similarities and differences with neutron star and white dwarf binaries. Until recently, this paradigm had not been directly tested with dedicated high-angular resolution radio imaging over entire outbursts. Moreover, such high-resolution monitoring campaigns had not previously targetted outbursts in which the compact object was either a neutron star or a white dwarf. To address this issue, we have embarked on the Jet Acceleration and Collimation Probe Of Transient X-Ray Binaries (JACPOT XRB) project, which aims to use high angular resolution observations to compare disk-jet coupling across the stellar mass scale, with the goal of probing the importance of the depth of the gravitational potential well, the...

  2. DEUTERIUM BURNING IN MASSIVE GIANT PLANETS AND LOW-MASS BROWN DWARFS FORMED BY CORE-NUCLEATED ACCRETION

    Energy Technology Data Exchange (ETDEWEB)

    Bodenheimer, Peter [UCO/Lick Observatory, Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); D' Angelo, Gennaro; Lissauer, Jack J. [Space Science and Astrobiology Division, NASA-Ames Research Center, Moffett Field, CA 94035 (United States); Fortney, Jonathan J. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Saumon, Didier, E-mail: peter@ucolick.org, E-mail: gennaro.dangelo@nasa.gov, E-mail: Jack.J.Lissauer@nasa.gov, E-mail: jfortney@ucolick.org, E-mail: dsaumon@lanl.gov [Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545 (United States)

    2013-06-20

    Using detailed numerical simulations, we study the formation of bodies near the deuterium-burning limit according to the core-nucleated giant planet accretion scenario. The objects, with heavy-element cores in the range 5-30 M{sub Circled-Plus }, are assumed to accrete gas up to final masses of 10-15 Jupiter masses (M{sub Jup}). After the formation process, which lasts 1-5 Myr and which ends with a ''cold-start'', low-entropy configuration, the bodies evolve at constant mass up to an age of several Gyr. Deuterium burning via proton capture is included in the calculation, and we determined the mass, M{sub 50}, above which more than 50% of the initial deuterium is burned. This often-quoted borderline between giant planets and brown dwarfs is found to depend only slightly on parameters, such as core mass, stellar mass, formation location, solid surface density in the protoplanetary disk, disk viscosity, and dust opacity. The values for M{sub 50} fall in the range 11.6-13.6 M{sub Jup}, in agreement with previous determinations that do not take the formation process into account. For a given opacity law during the formation process, objects with higher core masses form more quickly. The result is higher entropy in the envelope at the completion of accretion, yielding lower values of M{sub 50}. For masses above M{sub 50}, during the deuterium-burning phase, objects expand and increase in luminosity by one to three orders of magnitude. Evolutionary tracks in the luminosity versus time diagram are compared with the observed position of the companion to Beta Pictoris.

  3. Hyper-Eddington mass accretion on to a black hole with super-Eddington luminosity

    Science.gov (United States)

    Sakurai, Yuya; Inayoshi, Kohei; Haiman, Zoltán

    2016-10-01

    We perform 1D radiation hydrodynamical simulations to solve accretion flows on to massive black holes (BHs) with a very high rate. Assuming that photon trapping limits the luminosity emerging from the central region to L ≲ LEdd, Inayoshi, Haiman & Ostriker (2016) have shown that an accretion flow settles to a `hyper-Eddington solution, with a steady and isothermal (T ≃ 8000 K) Bondi profile reaching ≳ 5000 times the Eddington accretion rate dot{M}_Eddequiv L_Edd/c^2. Here, we address the possibility that gas accreting with finite angular momentum forms a bright nuclear accretion disc, with a luminosity exceeding the Eddington limit (1 ≲ L/LEdd ≲ 100). Combining our simulations with an analytic model, we find that a transition to steady hyper-Eddington accretion still occurs, as long as the luminosity remains below L/LEdd ≲ 35 (MBH/104 M⊙)3/2(n∞/105 cm-3)(T∞/104 K)-3/2(r⋆/1014 cm)-1/2, where n∞ and T∞ are the density and temperature of the ambient gas, and r⋆ is the radius of the photosphere, at which radiation emerges. If the luminosity exceeds this value, accretion becomes episodic. Our results can be accurately recovered in a toy model of an optically thick spherical shell, driven by radiation force into a collapsing medium. When the central source is dimmer than the above critical value, the expansion of the shell is halted and reversed by ram pressure of the collapsing medium, and by shell's weight. Our results imply that rapid, unimpeded hyper-Eddington accretion is possible even if the luminosity of the central source far exceeds the Eddington limit, and can be either steady or strongly episodic.

  4. Hyper-Eddington mass accretion onto a black hole with super-Eddington luminosity

    CERN Document Server

    Sakurai, Yuya; Haiman, Zoltán

    2016-01-01

    We perform one-dimensional radiation hydrodynamical simulations to solve spherically symmetric accretion flows onto massive black holes (BHs) with a very high rate. Assuming that photon trapping limits the luminosity emerging from the central region to $L\\lesssim L_{\\rm Edd}$, IHO16 have shown that a sufficiently rapid accretion flow settles to a "hyper-Eddington" solution, with a steady and isothermal ($T\\simeq 8000$ K) Bondi profile reaching $\\gtrsim 5000$ times the Eddington accretion rate $\\dot{M}_{\\rm Edd}\\equiv L_{\\rm Edd}/c^2$. Here we address the possibility that gas accreting with finite angular momentum forms a bright nuclear accretion disc, with a luminosity exceeding the Eddington limit ($1\\lesssim L/L_{\\rm Edd} \\lesssim 100$). Combining our simulations with an analytic model, we find that a transition to steady hyper-Eddington accretion still occurs, as long as the luminosity of the central source remains below $L/L_{\\rm Edd} \\lesssim 35~(M_{\\rm BH}/10^4~M_\\odot)^{3/2} (n_\\infty/10^5~{\\rm cm^{-3}...

  5. Mergers and Mass Accretion Rates in Galaxy Assembly: The Millennium Simulation Compared to Observations of z~2 Galaxies

    CERN Document Server

    Genel, S; Bouché, N; Sternberg, A; Naab, T; Förster-Schreiber, N M; Shapiro, K L; Tacconi, L J; Lutz, D; Cresci, G; Buschkamp, P; Davies, R I; Hicks, E K S

    2008-01-01

    Recent observations of UV-/optically selected, massive star forming galaxies at z~2 indicate that the baryonic mass assembly and star formation history is dominated by continuous rapid accretion of gas and internal secular evolution, rather than by major mergers. We use the Millennium Simulation to build new halo merger trees, and extract halo merger fractions and mass accretion rates. We find that even for halos not undergoing major mergers the mass accretion rates are plausibly sufficient to account for the high star formation rates observed in z~2 disks. On the other hand, the fraction of major mergers in the Millennium Simulation is sufficient to account for the number counts of submillimeter galaxies (SMGs), in support of observational evidence that these are major mergers. When following the fate of these two populations in the Millennium Simulation to z=0, we find that subsequent mergers are not frequent enough to convert all z~2 turbulent disks into elliptical galaxies at z=0. Similarly, mergers canno...

  6. Expression of Ankrd2 in fast and slow muscles and its response to stretch are consistent with a role in slow muscle function.

    NARCIS (Netherlands)

    Mckoy, G.; Hou, Y.; Yang, S.Y.; Vega Avelaira, D.; Degens, H.; Goldspink, G.; Coulton, G.R.

    2005-01-01

    In striated muscle, the structural genes associated with muscle fiber phenotype determination as well as muscle mass accretion are regulated largely by mechanical stimuli. Passive stretch of skeletal muscle stimulates muscle growth/hypertrophy and an increased expression of slow muscle genes. We pre

  7. The accretion of solar material onto white dwarfs: No mixing with core material implies that the mass of the white dwarf is increasing

    Directory of Open Access Journals (Sweden)

    Sumner Starrfield

    2014-02-01

    Full Text Available Cataclysmic Variables (CVs are close binary star systems with one component a white dwarf (WD and the other a larger cooler star that fills its Roche Lobe. The cooler star is losing mass through the inner Lagrangian point of the binary and some unknown fraction of this material is accreted by the WD. One consequence of the WDs accreting material, is the possibility that they are growing in mass and will eventually reach the Chandrasekhar Limit. This evolution could result in a Supernova Ia (SN Ia explosion and is designated the Single Degenerate Progenitor (SD scenario. This paper is concerned with the SD scenario for SN Ia progenitors. One problem with the single degenerate scenario is that it is generally assumed that the accreting material mixes with WD core material at some time during the accretion phase of evolution and, since the typical WD has a carbon-oxygen CO core, the mixing results in large amounts of carbon and oxygen being brought up into the accreted layers. The presence of enriched carbon causes enhanced nuclear fusion and a Classical Nova explosion. Both observations and theoretical studies of these explosions imply that more mass is ejected than is accreted. Thus, the WD in a Classical Nova system is losing mass and cannot be a SN Ia progenitor. However, the composition in the nuclear burning region is important and, in new calculations reported here, the consequences to the WD of no mixing of accreted material with core material have been investigated so that the material involved in the explosion has only a Solar composition. WDs with a large range in initial masses and mass accretion rates have been evolved. I find that once sufficient material has been accreted, nuclear burning occurs in all evolutionary sequences and continues until a thermonuclear runaway (TNR occurs and the WD either ejects a small amount of material or its radius grows to about 1012 cm and the evolution is ended. In all cases where mass ejection occurs

  8. Deuterium Burning in Massive Giant Planets and Low-Mass Brown Dwarfs formed by Core-Nucleated Accretion

    CERN Document Server

    Bodenheimer, Peter; Lissauer, Jack J; Fortney, Jonathan J; Saumon, Didier

    2013-01-01

    Formation of bodies near the deuterium-burning limit is considered by detailed numerical simulations according to the core-nucleated giant planet accretion scenario. The objects, with heavy-element cores in the range 5-30 Mearth, are assumed to accrete gas up to final masses of 10-15 Jupiter masses (Mjup). After the formation process, which lasts 1-5 Myr and which ends with a 'cold-start', low-entropy configuration, the bodies evolve at constant mass up to an age of several Gyr. Deuterium burning via proton capture is included in the calculation, and we determined the mass, M50, above which more than 50% of the initial deuterium is burned. This often-quoted borderline between giant planets and brown dwarfs is found to depend only slightly on parameters, such as core mass, stellar mass, formation location, solid surface density in the protoplanetary disk, disk viscosity, and dust opacity. The values for M50 fall in the range 11.6-13.6 Mjup, in agreement with previous determinations that do not take the formati...

  9. The accretion history of dark matter halos II: The connections with the mass power spectrum and the density profile

    CERN Document Server

    Correa, Camila A; Schaye, Joop; Duffy, Alan R

    2015-01-01

    We explore the relation between the structure and mass accretion histories of dark matter halos using a suite of cosmological simulations. We confirm that the formation time, defined as the time when the virial mass of the main progenitor equals the mass enclosed within the scale radius, correlates strongly with concentration. We provide a semi-analytic model for halo mass history that combines analytic relations with fits to simulations. This model has the functional form, $M(z) = M_{0}(1+z)^{\\alpha}e^{\\beta z}$, where the parameters $\\alpha$ and $\\beta$ are directly correlated with concentration. We then combine this model for the halo mass history with the analytic relations between $\\alpha$, $\\beta$ and the linear power spectrum derived by Correa et al. (2014) to establish the physical link between halo concentration and the initial density perturbation field. Finally, we provide fitting formulas for the halo mass history as well as numerical routines, we derive the accretion rate as a function of halo ma...

  10. X-Shooter study of accretion in $\\rho$-Ophiucus: very low-mass stars and brown dwarfs

    CERN Document Server

    Manara, C F; Natta, A; Alcalá, J M

    2015-01-01

    We present new VLT/X-Shooter optical and NIR spectra of a sample of 17 candidate young low-mass stars and BDs in the rho-Ophiucus cluster. We derived SpT and Av for all the targets, and then we determined their physical parameters. All the objects but one have M*<0.6 Msun, and 8 have mass below or close to the hydrogen-burning limit. Using the intensity of various emission lines present in their spectra, we determined the Lacc and Macc for all the objects. When compared with previous works targeting the same sample, we find that, in general, these objects are not as strongly accreting as previously reported, and we suggest that the reason is our more accurate estimate of the photospheric parameters. We also compare our findings with recent works in other slightly older star-forming regions to investigate possible differences in the accretion properties, but we find that the accretion properties for our targets have the same dependence on the stellar and substellar parameters as in the other regions. This l...

  11. A recent accretion burst in the low-mass protostar IRAS 15398-3359: ALMA imaging of its related chemistry

    CERN Document Server

    Jorgensen, Jes K; Sakai, Nami; Bergin, Edwin A; Brinch, Christian; Harsono, Daniel; Lindberg, Johan E; van Dishoeck, Ewine F; Yamamoto, Satoshi; Bisschop, Suzanne E; Persson, Magnus V

    2013-01-01

    Low-mass protostars have been suggested to show highly variable accretion rates through-out their evolution. Such changes in accretion, and related heating of their ambient envelopes, may trigger significant chemical variations on different spatial scales and from source-to-source. We present images of emission from C17O, H13CO+, CH3OH, C34S and C2H toward the low-mass protostar IRAS 15398-3359 on 0.5" (75 AU diameter) scales with the Atacama Large Millimeter/submillimeter Array (ALMA) at 340 GHz. The resolved images show that the emission from H13CO+ is only present in a ring-like structure with a radius of about 1-1.5" (150-200 AU) whereas the CO and other high dipole moment molecules are centrally condensed toward the location of the central protostar. We propose that HCO+ is destroyed by water vapor present on small scales. The origin of this water vapor is likely an accretion burst during the last 100-1000 years increasing the luminosity of IRAS 15398-3359 by a factor of 100 above its current luminosity....

  12. Limits On The Spin Up Of Stellar-Mass Black Holes Through A Spiral Stationary Accretion Shock Instability

    CERN Document Server

    Méndez, Enrique Moreno

    2015-01-01

    The spin of a number of black holes (BHs) in binary systems has been measured. In the case of BHs found in low-mass X-ray binaries (LMXBs) the observed values are in agreement with some theoretical predictions based on binary stellar evolution. However, using the same evolutionary models, the calculated spins of BHs in high-mass X-ray binaries (HMXBs) fall short compared to the observations. A possible solution to this conundrum is the accretion of high-specific-angular-momentum material after the formation of the BH, although this requires accretion above the Eddington limit. Another suggestion is that the observed high values of the BHs spin could be the result of an asymmetry during Core Collapse (CC). The only available energy to spin up the compact object during CC is its binding energy. A way to convert it to rotational kinetic energy is by using a Standing Accretion Shock Instability (SASI), which can develop during CC and push angular momentum into the central compact object through a spiral mode ($m ...

  13. Accretion and Evolution of ~2.5 Earth-mass Planets with Voluminous H/He Envelopes

    CERN Document Server

    Bodenheimer, Peter

    2014-01-01

    Formation of planets in the Neptune size range with low-mass, but voluminous, H_2/He gaseous envelopes is modeled by detailed numerical simulations according to the core-nucleated accretion scenario. Formation locations ranging from 0.5 to 4 AU from a star of 1 solar mass are considered. The final planets have heavy-element cores of 2.2--2.5 Earth masses and envelopes in the range 0.037--0.16 Earth masses. After the formation process, which lasts 2 Myr or less, the planets evolve at constant mass up to an age of several Gyr. For assumed equilibrium temperatures of 250, 500, and 1000 K, their calculated final radii are compared with those observed by the Kepler spacecraft. For the particular case of Kepler-11 f, we address the question whether it could have formed in situ or whether migration from a formation location farther out in the disk is required.

  14. [Variation of muscle mass and weight in critical patient].

    Science.gov (United States)

    Valls-Matarín, J; del Cotillo-Fuente, M; Grané-Mascarell, N; Quintana, S

    2015-01-01

    Quantify the muscle mass and body weight variation in critically ill patients and to identify associated factors. A descriptive follow-up study. Data for demographic variables, body weight, fluid balance, daily kilocalories, the amount of sedation and muscle relaxants received and motor physiotherapy applied were collected. Three consecutive measurements were performed in the brachial biceps and quadriceps rectus by using ultrasound, upon admission and every 5 days until discharge. 68 patients were included. Average age was of 73.5 [57-78,5] years. The median length of stay was 9.5 [5.5 -15] days. The median 16 (SD=5.7) daily kilocalories per kg/weight, 91.2% received sedation, 44.1% received muscle relaxants and 20% received physiotherapy. The patients presented a muscle wasting of 4.9 (SD=3.9)mm, p <.001 in the brachial biceps and 5.6 (SD=4.8)mm, p <.001 in the quadriceps rectus. Regression analysis selected the length of stay and the muscle relaxants are the most influential variables in the brachial biceps muscle wasting (R2=0.4), and length of stay as the most influential in the quadriceps rectus muscle wasting (R2=0.3). Patient's mean body weight on admission was of 81.1 (SD=15)kg and 81.2 (SD=14.2)kg on discharge, p=.95. The critically ill patient presents a significant muscle waste related with the length of stay and the treatment received with muscle relaxants. Patients are being discharged with a similar body weight to which they were admitted but with a significant reduction of muscle mass. Copyright © 2014 Elsevier España, S.L.U. y SEEIUC. All rights reserved.

  15. Relative appendicular skeletal muscle mass is associated with isokinetic muscle strength and balance in healthy collegiate men.

    Science.gov (United States)

    Kim, Sung-Eun; Hong, Ju; Cha, Jun-Youl; Park, Jung-Min; Eun, Denny; Yoo, Jaehyun; Jee, Yong-Seok

    2016-11-01

    There are few studies on the relationship between skeletal muscle mass and balance in the young ages. We investigated the relationship between appendicular skeletal muscle mass, isokinetic muscle strength of lower extremity, and balance among healthy young men using relative skeletal muscle index. Thirty men were grouped according to relative appendicular skeletal muscle mass index: higher skeletal muscle group (n = 15) and lower skeletal muscle group (n = 15). Static and dynamic balance abilities were measured using the following: a test where participants stood on one leg with eyes closed, a modified Clinical Test of Sensory Interaction on Balance (mCTSIB) with eyes open and eyes closed, a stability test, and limits of stability test. The muscle strength of lower extremities was measured with an isokinetic analyser in hip, knee, and ankle joints. Participants with higher appendicular skeletal muscle mass were significantly more stable in maintaining dynamic balance than those with lower appendicular skeletal muscle mass. Moreover, appendicular skeletal muscle mass index was positively correlated with dynamic balance ability. Participants with higher appendicular skeletal muscle mass had stronger strength in the lower extremity, and there were significant differences in the isokinetic torque ratios between groups. From these results, it can be inferred that higher appendicular skeletal muscle mass relates to muscle strength and the alteration in the peak torque ratio of the lower extremity, contributing to the maintenance of balance.

  16. GAS ACCRETION IS DOMINATED BY WARM IONIZED GAS IN MILKY WAY MASS GALAXIES AT z {approx} 0

    Energy Technology Data Exchange (ETDEWEB)

    Joung, M. Ryan; Putman, Mary E.; Bryan, Greg L.; Fernandez, Ximena; Peek, J. E. G., E-mail: moo@astro.columbia.edu [Department of Astronomy, Columbia University, 550 West 120th Street, New York, NY 10027 (United States)

    2012-11-10

    We perform high-resolution hydrodynamic simulations of a Milky Way mass galaxy in a fully cosmological setting using the adaptive mesh refinement code, Enzo, and study the kinematics of gas in the simulated galactic halo. We find that the gas inflow occurs mostly along filamentary structures in the halo. The warm-hot (10{sup 5} K 10{sup 6} K) ionized gases are found to dominate the overall mass accretion in the system (with M-dot = 3-5 M {sub Sun} yr{sup -1}) over a large range of distances, extending from the virial radius to the vicinity of the disk. Most of the inflowing gas (by mass) does not cool, and the small fraction that manages to cool does so primarily close to the galaxy (R {approx}< 100 kpc, with more pronounced cooling at smaller R), perhaps comprising the neutral gas that may be detectable as, e.g., high-velocity clouds. The neutral clouds are embedded within larger, accreting filamentary flows, and represent only a small fraction of the total mass inflow rate. The inflowing gas has relatively low metallicity (Z/Z {sub Sun} < 0.2). The outer layers of the filamentary inflows are heated due to compression as they approach the disk. In addition to the inflow, we find high-velocity, metal-enriched outflows of hot gas driven by supernova feedback. Our results are consistent with observations of halo gas at low z.

  17. Myoglobin plasma level related to muscle mass and fiber composition: a clinical marker of muscle wasting?

    Science.gov (United States)

    Weber, Marc-André; Kinscherf, Ralf; Krakowski-Roosen, Holger; Aulmann, Michael; Renk, Hanna; Künkele, Annette; Edler, Lutz; Kauczor, Hans-Ulrich; Hildebrandt, Wulf

    2007-08-01

    Progressive muscle wasting is a central feature of cancer-related cachexia and has been recognized as a determinant of poor prognosis and quality of life. However, until now, no easily assessable clinical marker exists that allows to predict or to track muscle wasting. The present study evaluated the potential of myoglobin (MG) plasma levels to indicate wasting of large locomotor muscles and, moreover, to reflect the loss of MG-rich fiber types, which are most relevant for daily performance. In 17 cancer-cachectic patients (weight loss 22%) and 27 age- and gender-matched healthy controls, we determined plasma levels of MG and creatine kinase (CK), maximal quadriceps muscle cross-sectional area (CSA) by magnetic resonance imaging, muscle morphology and fiber composition in biopsies from the vastus lateralis muscle, body cell mass (BCM) by impedance technique as well as maximal oxygen uptake (VO(2)max). In cachectic patients, plasma MG, muscle CSA, BCM, and VO(2)max were 30-35% below control levels. MG showed a significant positive correlation to total muscle CSA (r = 0.65, p max as an important functional readout. CK plasma levels appear to be less reliable because prolonged increases are observed in even subclinical myopathies or after exercise. Notably, cancer-related muscle wasting was not associated with increases in plasma MG or CK in this study.

  18. Intra-uterine growth retardation affects birthweight and postnatal development in pigs, impairing muscle accretion, duodenal mucosa morphology and carcass traits.

    Science.gov (United States)

    Alvarenga, A L N; Chiarini-Garcia, H; Cardeal, P C; Moreira, L P; Foxcroft, G R; Fontes, D O; Almeida, F R C L

    2013-01-01

    The present study investigated the occurrence of intra-uterine growth retardation (IUGR) in newborn (n=40) and 150-day-old (n=240) pigs of different birthweight ranges (high, HW: 1.8-2.2kg; low, LW: 0.8-1.2kg) from higher-parity commercial sows and its impact on their subsequent development and carcass traits in a Brazilian commercial production system. HW newborn pigs had heavier organs than LW pigs (Pmuscle fibres and a higher percentage of connective tissue in the semitendinosus muscle, greater fibre number per mm(2) and a lower height of the duodenal mucosa (Pgrowth performance, muscle accretion, duodenal mucosa morphology and carcass traits.

  19. Expression of porcine myostatin prodomain genomic sequence leads to a decrease in muscle growth, but significant intramuscular fat accretion in transgenic pigs.

    Science.gov (United States)

    Myostatin, a member of TGF-beta superfamily, is a dominant inhibitor of skeletal muscle development and growth. Previously, skeletal muscle-specific over-expression of myostatin prodomain cDNA (5’-region 886 nucleotide) dramatically increased growth performance and muscle mass in transgenic mice. I...

  20. Associations of Sarcopenia and Sarcopenic Obesity With Metabolic Syndrome Considering Both Muscle Mass and Muscle Strength.

    Science.gov (United States)

    Lee, Jihye; Hong, Yeon-pyo; Shin, Hyun Ju; Lee, Weonyoung

    2016-01-01

    We investigated the associations of sarcopenia-defined both in terms of muscle mass and muscle strength-and sarcopenic obesity with metabolic syndrome. Secondary data pertaining to 309 subjects (85 men and 224 women) were collected from participants in exercise programs at a health center in a suburban area. Muscle mass was measured using bioelectrical impedance analysis, and muscle strength was measured via handgrip strength. Sarcopenia based on muscle mass alone was defined as a weight-adjusted skeletal muscle mass index more than two standard deviations below the mean of a sex-specific young reference group (class II sarcopenia). Two cut-off values for low handgrip strength were used: the first criteria were obesity was defined as the combination of class II sarcopenia and being in the two highest quintiles of total body fat percentage among the subjects. The associations of sarcopenia and sarcopenic obesity with metabolic syndrome were evaluated using logistic regression models. The age-adjusted risk ratios (RRs) of metabolic syndrome being compared in people with or without sarcopenia defined in terms of muscle mass were 1.25 (95% confidence interval [CI], 1.06 to 1.47, p=0.008) in men and 1.12 (95% CI, 1.06 to 1.19, pmetabolic syndrome being compared in people with or without sarcopenic obesity were 1.31 in men (95% CI, 1.10 to 1.56, p=0.003) and 1.17 in women (95% CI, 1.10 to 1.25, pobesity with metabolic syndrome were statistically significant in both men and women. Therefore, sarcopenia and sarcopenic obesity must be considered as part of the community-based management of non-communicable diseases.

  1. MASS ACCRETION AND ITS EFFECTS ON THE SELF-SIMILARITY OF GAS PROFILES IN THE OUTSKIRTS OF GALAXY CLUSTERS

    Energy Technology Data Exchange (ETDEWEB)

    Lau, Erwin T.; Nagai, Daisuke; Avestruz, Camille [Department of Physics, Yale University, New Haven, CT 06520 (United States); Nelson, Kaylea [Yale Center for Astronomy and Astrophysics, Yale University, New Haven, CT 06520 (United States); Vikhlinin, Alexey, E-mail: erwin.lau@yale.edu [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States)

    2015-06-10

    Galaxy clusters exhibit remarkable self-similar behavior which allows us to establish simple scaling relationships between observable quantities and cluster masses, making galaxy clusters useful cosmological probes. Recent X-ray observations suggested that self-similarity may be broken in the outskirts of galaxy clusters. In this work, we analyze a mass-limited sample of massive galaxy clusters from the Omega500 cosmological hydrodynamic simulation to investigate the self-similarity of the diffuse X-ray emitting intracluster medium (ICM) in the outskirts of galaxy clusters. We find that the self-similarity of the outer ICM profiles is better preserved if they are normalized with respect to the mean density of the universe, while the inner profiles are more self-similar when normalized using the critical density. However, the outer ICM profiles as well as the location of accretion shock around clusters are sensitive to their mass accretion rate, which causes the apparent breaking of self-similarity in cluster outskirts. We also find that the collisional gas does not follow the distribution of collisionless dark matter (DM) perfectly in the infall regions of galaxy clusters, leading to 10% departures in the gas-to-DM density ratio from the cosmic mean value. Our results have a number implications for interpreting observations of galaxy clusters in X-ray and through the Sunyaev–Zel’dovich effect, and their applications to cosmology.

  2. Photometric determination of the mass accretion rate of pre-main sequence stars. IV. Recent star formation in NGC 602

    CERN Document Server

    De Marchi, Guido; Panagia, Nino

    2013-01-01

    We have studied the young stellar populations in NGC 602, in the Small Magellanic Cloud, using a novel method that we have developed to combine Hubble Space Telescope photometry in the V, I, and Halpha bands. We have identified about 300 pre-main sequence (PMS) stars, all of which are still undergoing active mass accretion, and have determined their physical parameters (effective temperature, luminosity, age, mass and mass accretion rate). Our analysis shows that star formation has been present in this field over the last 60 Myr. In addition, we can recognise at least two clear, distinct, and prominent episodes in the recent past: one about 2 Myr ago, but still ongoing in regions of higher nebulosity, and one (or more) older than 30 Myr, encompassing both stars dispersed in the field and two smaller clusters located about 100 arcsec north of the centre of NGC 602. The relative locations of younger and older PMS stars do not imply a causal effect or triggering of one generation on the other. The strength of th...

  3. Relation between body mass index percentile and muscle strength ...

    African Journals Online (AJOL)

    Noha Abdel Kader Abdel Kader Hasan

    2016-02-01

    Feb 1, 2016 ... time to fatigue to evaluate endurance time. ... a positive correlation between muscle strength and body mass index ... Isokinetic dynamometry, hand-held dynamometry, field tests, .... dominant side of each child was selected and attached. ... toward elbow flexion (since the elbow flexors were not measured.

  4. Muscle strength rather than muscle mass is associated with standing balance in elderly outpatients.

    Science.gov (United States)

    Bijlsma, Astrid Y; Pasma, Jantsje H; Lambers, Dorine; Stijntjes, Marjon; Blauw, Gerard Jan; Meskers, Carel G M; Maier, Andrea B

    2013-07-01

    Assessment of the association of muscle characteristics with standing balance is of special interest, as muscles are a target for potential intervention (ie, by strength training). Cross-sectional study. Geriatric outpatient clinic. The study included 197 community-dwelling elderly outpatients (78 men, 119 women; mean age 82 years). Muscle characteristics included handgrip and knee extension strength, appendicular lean mass divided by height squared (ALM/height(2)), and lean mass as percentage of body mass. Two aspects of standing balance were assessed: the ability to maintain balance, and the quality of balance measured by Center of Pressure (CoP) movement during 10 seconds of side-by-side, semitandem, and tandem stance, with both eyes open and eyes closed. Logistic and linear regression models were adjusted for age, and additionally for height, body mass, cognitive function, and multimorbidity. Handgrip and knee extension strength, adjusted for age, were positively related to the ability to maintain balance with eyes open in side-by-side (P = .011; P = .043), semitandem (P = .005; P = .021), and tandem stance (P = .012; P = .014), and with eyes closed in side-by-side (P = .004; P = .004) and semitandem stance (not significant; P = .046). Additional adjustments affected the results only slightly. ALM/height(2) and lean mass percentage were not associated with the ability to maintain standing balance, except for an association between ALM/height(2) and tandem stance with eyes open (P = .033) that disappeared after additional adjustments. Muscle characteristics were not associated with CoP movement. Muscle strength rather than muscle mass was positively associated with the ability to maintain standing balance in elderly outpatients. Assessment of CoP movement was not of additional value. Copyright © 2013 American Medical Directors Association, Inc. Published by Elsevier Inc. All rights reserved.

  5. No Change of Body Mass, Fat Mass, and Skeletal Muscle Mass in Ultraendurance Swimmers after 12 Hours of Swimming

    Science.gov (United States)

    Knechtle, Beat; Knechtle, Patrizia; Kaul, Rene; Kohler, Gotz

    2009-01-01

    We evaluated whether ultraendurance swimmers suffer a change of body mass, fat mass, skeletal muscle mass, total body water, and specific gravity of urine during a 12-hr swim in 12 male Caucasian ultraswimmers. Proton nuclear magnetic resonance of urine samples before and after the race was performed to detect alanine, lactate, and…

  6. Peak muscle perfusion and oxygen uptake in humans: importance of precise estimates of muscle mass.

    Science.gov (United States)

    Râdegran, G; Blomstrand, E; Saltin, B

    1999-12-01

    The knee extensor exercise model was specifically developed to enable in vivo estimates of peak muscle blood flow and O(2) uptake in humans. The original finding, using thermodilution measurements to measure blood flow in relation to muscle mass [P. Andersen and B. Saltin. J. Physiol. (Lond.) 366: 233-249, 1985], was questioned, however, as the measurements were two- to threefold higher than those previously obtained with the (133)Xe clearance and the plethysmography technique. As thermodilution measurements have now been confirmed by other methods and independent research groups, we aimed to address the impact of muscle mass estimates on the peak values of muscle perfusion and O(2) uptake. In the present study, knee extensor volume was determined from multiple measurements with computer tomography along the full length of the muscle. In nine healthy humans, quadriceps muscle volume was 2.36 +/- 0.17 (range 1. 31-3.27) liters, corresponding to 2.48 +/- 0.18 (range 1.37-3.43) kg. Anthropometry overestimated the muscle volume by approximately 21-46%, depending on whether quadriceps muscle length was estimated from the patella to either the pubic bone, inguinal ligament, or spina iliaca anterior superior. One-legged, dynamic knee extensor exercise up to peak effort of 67 +/- 7 (range 55-100) W rendered peak values for leg blood flow (thermodilution) of 5.99 +/- 0.66 (range 4.15-9.52) l/min and leg O(2) uptake of 856 +/- 109 (range 590-1,521) ml/min. Muscle perfusion and O(2) uptake reached peak values of 246 +/- 24 (range 149-373) and 35.2 +/- 3.7 (range 22.6-59. 6) ml. min(-1). 100 g muscle(-1), respectively. These peak values are approximately 19-33% larger than those attained by applying anthropometric muscle mass estimates. In conclusion, the present findings emphasize that peak perfusion and O(2) uptake in human skeletal muscle may be up to approximately 30% higher than previous anthropometric-based estimates that use equivalent techniques for blood flow

  7. Alfacalcidol improves muscle power, muscle function and balance in elderly patients with reduced bone mass.

    Science.gov (United States)

    Schacht, E; Ringe, Johann D

    2012-01-01

    We investigated the effect of daily therapy with 1 mcg alfacalcidol (Doss(®)-TEVA/AWD-pharma) on muscle power, muscle function, balance performance and fear of falls in an open, multi-centered, uncontrolled, prospective study on a cohort of patients with reduced bone mass. Among the 2,097 participants, 87.1% were post-menopausal women and 12.9% were men. Mean age was 74.8 years and mean body mass index (BMI) 26.3 kg/m². A total of 75.3% of the study population had osteoporosis, 81% a diagnosis of "increased risk of falls" and 70.1% had a creatinine clearance (CrCl) of muscle function and muscle power tests at onset and after 3 and 6 months: the timed up and go test (TUG) and the chair rising test (CRT). At baseline and after 6 months, participants performed the tandem gait test (TGT) and filled out a questionnaire evaluating fear of falling. Successful performance in the muscle tests is associated with a significantly lower risk of falls and non-vertebral fractures in elderly patients (successful test performance: TUG ≤ 10 s (sec), CRT ≤ 10 s, TGT ≥ 8 steps). A significant improvement in the performance of the two muscle tests was proved already after 3 months of treatment with alfacalcidol and further increased by the end of the therapeutic intervention. There were significant increases in the number of participants able to successfully perform the tests: 24.6% at baseline and 46.3% at the end of trial for the TUG (P muscle power, muscle function and balance and reduces fear of falls. The significant improvement in the three muscle and balance tests and fear of falls may have a preventative effect on falls and fractures. We suggest that the quantitative risk tests used in this study could be reliable surrogate parameters for the risk of falls and fractures in elderly patients.

  8. A RECENT ACCRETION BURST IN THE LOW-MASS PROTOSTAR IRAS 15398-3359: ALMA IMAGING OF ITS RELATED CHEMISTRY

    Energy Technology Data Exchange (ETDEWEB)

    Jørgensen, Jes K.; Brinch, Christian; Lindberg, Johan E.; Bisschop, Suzanne E. [Niels Bohr Institute, University of Copenhagen, Juliane Maries Vej 30, DK-2100 Copenhagen Ø. (Denmark); Visser, Ruud; Bergin, Edwin A. [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 48109-1042 (United States); Sakai, Nami; Yamamoto, Satoshi [Department of Physics, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Harsono, Daniel; Van Dishoeck, Ewine F.; Persson, Magnus V., E-mail: jeskj@nbi.dk [Leiden Observatory, Leiden University, P.O. Box 9513, NL-2300 RA Leiden (Netherlands)

    2013-12-20

    Low-mass protostars have been suggested to show highly variable accretion rates throughout their evolution. Such changes in accretion, and related heating of their ambient envelopes, may trigger significant chemical variations on different spatial scales and from source-to-source. We present images of emission from C{sup 17}O, H{sup 13}CO{sup +}, CH{sub 3}OH, C{sup 34}S and C{sub 2}H toward the low-mass protostar IRAS 15398-3359 on 0.''5 (75 AU diameter) scales with the Atacama Large Millimeter/submillimeter Array at 340 GHz. The resolved images show that the emission from H{sup 13}CO{sup +} is only present in a ring-like structure with a radius of about 1-1.''5 (150-200 AU) whereas the CO and other high dipole moment molecules are centrally condensed toward the location of the central protostar. We propose that HCO{sup +} is destroyed by water vapor present on small scales. The origin of this water vapor is likely an accretion burst during the last 100-1000 yr increasing the luminosity of IRAS 15398-3359 by a factor of 100 above its current luminosity. Such a burst in luminosity can also explain the centrally condensed CH{sub 3}OH and extended warm carbon-chain chemistry observed in this source and furthermore be reflected in the relative faintness of its compact continuum emission compared to other protostars.

  9. The Regulation of Muscle Mass by Endogenous Glucocorticoids

    Directory of Open Access Journals (Sweden)

    Daniel L Marks

    2015-02-01

    Full Text Available Glucocorticoids are highly conserved fundamental regulators of energy homeostasis. In response to stress in the form of perceived danger or acute inflammation, glucocorticoids are released from the adrenal gland, rapidly mobilizing energy from carbohydrate, fat and protein stores. In the case of inflammation, mobilized protein is critical for the rapid synthesis of acute phase reactants and an efficient immune response to infection. While adaptive in response to infection, chronic mobilization can lead to a p rofound depletion of energy stores. Skeletal muscle represents the major body store of protein, and can become substantially atrophied under conditions of chronic inflammation. Glucocorticoids elicit the atrophy of muscle by increasing the rate of protein degradation by the ubiquitin-proteasome system and autophagy lysosome system. Protein synthesis is also suppressed at the level of translational initiation, preventing the production of new myofibrillar protein. Glucocorticoids also antagonize the action of anabolic regulators such as insulin further exacerbating the loss of protein and muscle mass. The loss of muscle mass in the context of chronic disease is a key feature of cachexia and contributes substantially to morbidity and mortality. A growing body of evidence demonstrates that glucocorticoid signaling is a common mediator of wasting, irrespective of the underlying initiator or disease state. This review will highlight fundamental mechanisms of glucocorticoid signaling and detail the mechanisms of glucocorticoid-induced muscle atrophy. Additionally, the evidence for glucocorticoids as a driver of muscle wasting in numerous disease states will be discussed. Given the burden of wasting diseases and the nodal nature of glucocorticoid signaling, effective anti-glucocorticoid therapy would be a valuable clinical tool. Therefore, the progress and potential pitfalls in the development of glucocorticoid antagonists for muscle wasting will

  10. The regulation of muscle mass by endogenous glucocorticoids.

    Science.gov (United States)

    Braun, Theodore P; Marks, Daniel L

    2015-01-01

    Glucocorticoids are highly conserved fundamental regulators of energy homeostasis. In response to stress in the form of perceived danger or acute inflammation, glucocorticoids are released from the adrenal gland, rapidly mobilizing energy from carbohydrate, fat and protein stores. In the case of inflammation, mobilized protein is critical for the rapid synthesis of acute phase reactants and an efficient immune response to infection. While adaptive in response to infection, chronic mobilization can lead to a profound depletion of energy stores. Skeletal muscle represents the major body store of protein, and can become substantially atrophied under conditions of chronic inflammation. Glucocorticoids elicit the atrophy of muscle by increasing the rate of protein degradation by the ubiquitin-proteasome system and autophagy lysosome system. Protein synthesis is also suppressed at the level of translational initiation, preventing the production of new myofibrillar protein. Glucocorticoids also antagonize the action of anabolic regulators such as insulin further exacerbating the loss of protein and muscle mass. The loss of muscle mass in the context of chronic disease is a key feature of cachexia and contributes substantially to morbidity and mortality. A growing body of evidence demonstrates that glucocorticoid signaling is a common mediator of wasting, irrespective of the underlying initiator or disease state. This review will highlight fundamental mechanisms of glucocorticoid signaling and detail the mechanisms of glucocorticoid-induced muscle atrophy. Additionally, the evidence for glucocorticoids as a driver of muscle wasting in numerous disease states will be discussed. Given the burden of wasting diseases and the nodal nature of glucocorticoid signaling, effective anti-glucocorticoid therapy would be a valuable clinical tool. Therefore, the progress and potential pitfalls in the development of glucocorticoid antagonists for muscle wasting will be discussed.

  11. The accretion history of dark matter halos III: A physical model for the concentration-mass relation

    CERN Document Server

    Correa, Camila A; Schaye, Joop; Duffy, Alan R

    2015-01-01

    We present a semi-analytic, physically motivated model for dark matter halo concentration as a function of halo mass and redshift. The semi-analytic model is intimately based on hierarchical structure formation. It uses an analytic model for the halo mass accretion history, based on extended Press Schechter (EPS) theory, and an empirical relation between concentration and an appropriate definition of formation time obtained through fits to the results of numerical simulations. The resulting concentration-mass relations are tested against the simulations and do not exhibit an upturn at high masses or high redshifts as claimed by recent works. Because our semi-analytic model is based on EPS theory, it can be applied to wide ranges in mass, redshift and cosmology. We predict a change of slope in the z=0 concentration-mass relation at a mass scale of $10^{11}\\rm{M}_{\\odot}$, that is caused by the varying power in the density perturbations. We provide best-fitting expressions of the $c-M$ relations as well as nume...

  12. Changes in lower extremity muscle mass and muscle strength after weight loss in obese patients with knee osteoarthritis

    DEFF Research Database (Denmark)

    Henriksen, Marius; Christensen, Robin; Danneskiold-Samsøe, Bente

    2012-01-01

    To investigate the effects of low-energy diet-induced weight loss on lower-extremity muscle mass and knee muscle strength in obese patients with knee osteoarthritis (OA), and the associations of these effects.......To investigate the effects of low-energy diet-induced weight loss on lower-extremity muscle mass and knee muscle strength in obese patients with knee osteoarthritis (OA), and the associations of these effects....

  13. The HI Mass Density in Galactic Halos, Winds, and Cold Accretion as Traced by MgII Absorption

    CERN Document Server

    Kacprzak, G G

    2011-01-01

    It is well established that MgII absorption lines detected in background quasar spectra arise from gas structures associated with foreground galaxies. The degree to which galaxy evolution is driven by the gas cycling through halos is highly uncertain because their gas mass density is poorly constrained. Fitting the MgII equivalent width (W) distribution with a Schechter function and applying the N(HI)-W correlation of Menard & Chelouche, we computed Omega(HI)_MgII ~ Omega(HI)_halo =(1.41 +0.75 -0.44)x10^-4 for 0.4accreting and/or outflowing halo gas not locked up in cold neutral clouds. We deduce the cosmic HI gas mass density fraction in galactic halos traced by MgII absorption is Omega(HI)_halo/Omega(HI)_DLA=15% and Omega(HI)_halo/Omega_b=0.3%. Citing several lines of evidence, we propose infall/accretion material is sampled by small W whereas outflow/winds are sampled by large W, and find Omega(HI)_infall is consistent...

  14. Photometry of long-period algol binaries. III - The accretion disk and mass transfer in RZ Ophiuchi

    Science.gov (United States)

    Olson, Edward C.

    1987-11-01

    Five-color photometric observations of RZ Oph have been obtained from 1981 through 1986, in an effort to deduce the properties of the accretion disk in this long-period Algol. The partial eclipse of the disk by the cool star, and the partial occultation of the cool star by the disk, have both been observed in some detail. A simple gravitationally stratified model of the disk accounts very well for the emitted flux. The disk is viewed nearly edge-on, and is of moderate optical thickness. The principal extinction source in the disk is Rayleigh scattering from neutral hydrogen, and H(-) contributes to the thermal absorption. Disk temperatures run from about 5600 K to about 4400 K at the edge of the disk, and the disk appears to overflow the Roche lobe of the hot star. Most of the disk's luminosity is supplied by gravitational accretion, implying a mass-transfer rate of less than about 10 to the -6th solar mass/yr. Brightness fluctuations of the disk seem to account for small intrinsic scatter that is present in the observations at most phases.

  15. Counteracting age-related loss of skeletal muscle mass

    DEFF Research Database (Denmark)

    Bechshøft, Rasmus; Reitelseder, Søren; Højfeldt, Grith

    2016-01-01

    . Moreover, we will evaluate changes in physical performance, muscle fiber type and acute anabolic response to whey protein ingestion, sensory adaptation, gut microbiome, and a range of other measures, combined with questionnaires on life quality and qualitative interviews with selected subjects. The CALM...... at both societal and individual levels. Only a few longitudinal studies have been reported, but whey protein supplementation seems to improve muscle mass and function, and its combination with heavy strength training appears even more effective. However, heavy resistance training may reduce adherence...

  16. The mass donor star and the accretion disc of the dwarf nova V2051 Ophiuchi in the infrared

    Science.gov (United States)

    Wojcikiewicz, Eduardo; Baptista, Raymundo; Ribeiro, Tiago

    2016-07-01

    We report the analysis of infrared JHK_s high speed photometry of the dwarf nova V2051 Oph in quiescence. We model the ellipsoidal variations in the light curve to measure the fluxes of the mass donor star. Its colors are consistent with an M8 ± 1 spectral type with an equivalent blackbody temperature of T_{bb}= (2700± 300) K, in agreement with spectroscopic measurements and with theoretical expectation for donor stars at the same orbital period. We use the mass donor star fluxes and the Barnes & Evans relation to find a photometric parallax distance of (102 ± 16) pc to the binary. At this distance the outbursts of V2051 Oph occur at disc temperatures everywhere lower than the minimum/critical temperature predicted by the disc instability model, underscoring previous suggestions that they are powered by mass transfer bursts. We subtract the contribution of the mass donor star and apply eclipse mapping techniques to the remaining light curve in order to investigate the structure and emission of its accretion disc. The infrared accretion disc is bright and 'blue' in the inner regions and becomes progressively fainter and redder with increasing radii, indicating that the disc temperature decreases with radius. Bulges in the eclipse shape, more prominent in the H and K_s bands, lead to asymmetric arcs in the eclipse maps reminiscent of the spiral arms found in disc maps of outbursting dwarf novae. The arcs show an azimuthal extent of ˜90^o, extend from the intermediate to the outer disc regions (0.3-0.4 R_{L1}, where R_{L1} is the distance from disc center to the inner lagrangian point), and account for ≃ 30 per cent of the total flux in the H and K_s bands.

  17. Counteracting age-related loss of skeletal muscle mass

    DEFF Research Database (Denmark)

    Bechshøft, Rasmus; Reitelseder, Søren; Højfeldt, Grith;

    2016-01-01

    at both societal and individual levels. Only a few longitudinal studies have been reported, but whey protein supplementation seems to improve muscle mass and function, and its combination with heavy strength training appears even more effective. However, heavy resistance training may reduce adherence...... to training, thereby attenuating the overall benefits of training. We hypothesize that light load resistance training is more efficient when both adherence and physical improvement are considered longitudinally. We launched the interdisciplinary project on Counteracting Age-related Loss of Skeletal Muscle....... Moreover, we will evaluate changes in physical performance, muscle fiber type and acute anabolic response to whey protein ingestion, sensory adaptation, gut microbiome, and a range of other measures, combined with questionnaires on life quality and qualitative interviews with selected subjects. The CALM...

  18. The fight for accretion: discovery of intermittent mass transfer in BB Doradus in the low state

    CERN Document Server

    Rodríguez-Gil, P; Long, K S; Gänsicke, B T; Torres, M A P; Rubio-Díez, M M; Santander-García, M

    2012-01-01

    Our long-term photometric monitoring of southern nova-like cataclysmic variables with the 1.3-m SMARTS telescope found BB Doradus fading from V ~ 14.3 towards a deep low state at V ~ 19.3 in April 2008. Here we present time-resolved optical spectroscopy of BB Dor in this faint state in 2009. The optical spectrum in quiescence is a composite of a hot white dwarf with Teff = 30000 +- 5000 K and a M3-4 secondary star with narrow emission lines (mainly of the Balmer series and HeI) superposed. We associate these narrow profiles with an origin on the donor star. Analysis of the radial velocity curve of the H-alpha emission from the donor star allowed the measurement of an orbital period of 0.154095 +- 0.000003 d (3.69828 +- 0.00007 h), different from all previous estimates. We detected episodic accretion events which veiled the spectra of both stars and radically changed the line profiles within a timescale of tens of minutes. This shows that accretion is not completely quenched in the low state. During these accr...

  19. Coronal geometry at low mass-accretion rates from XMM and NuSTAR spectra

    Science.gov (United States)

    Fuerst, F.; NuSTAR Binaries Team; NuSTAR AGN Team

    2016-06-01

    At very low Eddington luminosities the structure and physics of the accretion flow around a black hole are still debated, in particular in the inner most regions. By making sensitive measurements of the relativistic blurring of the X-ray reflection spectrum we investigate these physics, a task for which XMM-Newton, in combination with hard X-ray coverage provided by NuSTAR or Hitomi, is ideally suited and will continue to be unique for years to come. I will present results from XMM and NuSTAR observations of the radio-galaxy Cen A and of the X-ray binary GRS 1739-278 during the decline of its outburst. While Cen A shows a prominent iron line, the broad-band spectrum shows no evidence of reflection. This lack of reflection can best be explained by a jet origin of the hard X-rays or a significantly truncated accretion disk. The iron line can be self-consistently explained when assuming an optically thick torus surrounding the super-massive black-hole. The broad-band X-ray spectrum of GRS 1739-278 can be well described by a simple power-law or Comptonization continuum. A weak relativistic reflection model results in a small but significant improvement of the statistical quality of the fit. This relativistic model indicates a strongly truncated disk.

  20. Diagnostic ultrasound estimates of muscle mass and muscle quality discriminate between women with and without sarcopenia

    Directory of Open Access Journals (Sweden)

    Catheeja eIsmail

    2015-10-01

    Full Text Available Introduction: Age-related changes in muscle mass and muscle tissue composition contribute to diminished strength in older adults. The objectives of this study are to examine if an assessment method using mobile diagnostic ultrasound augments well-known determinants of lean body mass (LBM to aid sarcopenia staging, and if a sonographic measure of muscle quality is associated with muscle performance.Methods: Twenty community-dwelling female subjects participated in the study (age = 43.4 ±20.9 years; BMI: 23.8, interquartile range: 8.5. Dual energy X-ray absorptiometry (DXA and diagnostic ultrasound morphometry were used to estimate LBM. Muscle tissue quality was estimated via the echogenicity using grayscale histogram analysis. Peak force was measured with grip dynamometry and scaled for body size. Bivariate and multiple regression analyses were used to determine the association of the predictor variables with appendicular lean mass (aLM/ht2, and examine the relationship between scaled peak force values and muscle echogenicity. The sarcopenia LBM cut point value of 6.75 kg/m2 determined participant assignment into the Normal LBM and Low LBM subgroups.Results: The selected LBM predictor variables were body mass index (BMI, ultrasound morphometry, and age. Although BMI exhibited a significant positive relationship with aLM/ht2 (adj. R2 = .61, p < .001, the strength of association improved with the addition of ultrasound morphometry and age as predictor variables (adj. R2 = .85, p < .001. Scaled peak force was associated with age and echogenicity (adj. R2 = .53, p < .001, but not LBM. The Low LBM subgroup of women (n = 10 had higher scaled peak force, lower BMI, and lower echogenicity values in comparison to the Normal LBM subgroup (n = 10; p < .05.Conclusions: Diagnostic ultrasound morphometry values are associated with LBM, and improve the BMI predictive model for aLM/ht2 in women. In addition, ultrasound proxy measures of muscle quality are more

  1. Discovery and Observations of ASASSN-13db, an EXor Accretion Event on a Low-Mass T Tauri Star

    CERN Document Server

    Holoien, Thomas W -S; Stanek, Krzysztof Z; Kochanek, Christopher S; Shappee, B J; Zhu, Z; Sicilia-Aguilar, A; Grupe, D; Croxall, K; Adams, J; Simon, J D; McGraw, N Morell S M; Wagner, R M; Basu, U; Beacom, J F; Bersier, D; Brimacombe, J; Jencson, J; Pojmanski, G; Starrfield, S G; Szczygieł, D M; Woodward, C E

    2014-01-01

    We discuss ASASSN-13db, an EXor accretion event on the young stellar object (YSO) SDSS J051011.01$-$032826.2 (hereafter SDSSJ0510) discovered by the All-Sky Automated Survey for SuperNovae (ASAS-SN). Using archival photometric data of SDSSJ0510 we construct a pre-outburst spectral energy distribution (SED) and find that it is consistent with a low-mass class II YSO near the Orion star forming region ($d \\sim 420$ pc). We present follow-up photometric and spectroscopic observations of the source after the $\\Delta V \\sim-$3.7 mag outburst that began in September 2013. These data indicate an increase in temperature and luminosity consistent with an accretion rate of $\\sim10^{-7}$ $\\rm{M}_\\odot$ yr$^{-1}$, three-to-five orders of magnitude greater than in quiescence. Spectroscopic observations show a forest of narrow emission lines dominated by neutral metallic lines from Fe I and some low-ionization lines. The properties of ASASSN-13db are similar to those of the EXor prototype EX~Lupi in late 2008 during its st...

  2. Mass measurement of 56Sc reveals a small A=56 odd-even mass staggering, implying a cooler accreted neutron star crust

    CERN Document Server

    Meisel, Z; Ahn, S; Bazin, D; Brown, B A; Browne, J; Carpino, J F; Chung, H; Cole, A L; Cyburt, R H; Estradé, A; Famiano, M; Gade, A; Langer, C; Matoš, M; Mittig, W; Montes, F; Morrissey, D J; Pereira, J; Schatz, H; Schatz, J; Scott, M; Shapira, D; Smith, K; Stevens, J; Tan, W; Tarasov, O; Towers, S; Wimmer, K; Winkelbauer, J R; Yurkon, J; Zegers, R G T

    2015-01-01

    We present the mass excesses of 52-57Sc, obtained from recent time-of-flight nuclear mass measurements at the National Superconducting Cyclotron Laboratory at Michigan State University. The masses of 56Sc and 57Sc were determined for the first time with atomic mass excesses of -24.85(59)(+0 -54) MeV and -21.0(1.3) MeV, respectively, where the asymmetric uncertainty for 56Sc was included due to possible contamination from a long-lived isomer. The 56Sc mass indicates a small odd-even mass staggering in the A = 56 mass-chain towards the neutron drip line, significantly deviating from trends predicted by the global FRDM mass model and favoring trends predicted by the UNEDF0 and UNEDF1 density functional calculations. Together with new shell-model calculations of the electron-capture strength function of 56Sc, our results strongly reduce uncertainties in model calculations of the heating and cooling at the 56Ti electron-capture layer in the outer crust of accreting neutron stars. We found that, in contrast to prev...

  3. Mass accretion processes in magnetic fields: formation of quasi-Keplerian discs

    Energy Technology Data Exchange (ETDEWEB)

    Kaburaki, O.

    1987-11-15

    An axisymmetric, steady-state solution is obtained for geometrically thin accretion discs in external magnetic fields. The main features of this solution are as follows. The azimuthal velocity of a disc plasma is somewhat reduced from the Keplerian value owing to the pressure effect enhanced by the inclusion of a magnetic field. The magnetic stress takes the place of viscous stress in the standard disc model, and extracts angular momentum from the disc. About a half of the gravitational energy is released in the the disc, through the Joule dissipation and the work done against the pressure force. The vertical flow and current are also included in the calculation. Analogously to the parameter ..cap alpha.. in the standard model, the solution contains essentially one parameter ..delta.. which specifies the size of the electrical resistivity.

  4. The accretion history of dark matter haloes - III. A physical model for the concentration-mass relation

    Science.gov (United States)

    Correa, Camila A.; Wyithe, J. Stuart B.; Schaye, Joop; Duffy, Alan R.

    2015-09-01

    We present a semi-analytic, physically motivated model for dark matter halo concentration as a function of halo mass and redshift. The semi-analytic model combines an analytic model for the halo mass accretion history (MAH), based on extended Press-Schechter (EPS) theory, with an empirical relation between concentration and formation time obtained through fits to the results of numerical simulations. Because the semi-analytic model is based on EPS theory, it can be applied to wide ranges in mass, redshift and cosmology. The resulting concentration-mass (c-M) relations are found to agree with the simulations, and because the model applies only to relaxed haloes, they do not exhibit the upturn at high masses or high redshifts found by some recent works. We predict a change of slope in the z ˜ 0 c-M relation at a mass-scale of 1011 M⊙. We find that this is due to the change in the functional form of the halo MAH, which goes from being dominated by an exponential (for high-mass haloes) to a power law (for low-mass haloes). During the latter phase, the core radius remains approximately constant, and the concentration grows due to the drop of the background density. We also analyse how the c-M relation predicted by this work affects the power produced by dark matter annihilation, finding that at z = 0 the power is two orders of magnitude lower than that obtained from extrapolating best-fitting c-M relations. We provide fits to the c-M relations as well as numerical routines to compute concentrations and MAHs.†

  5. The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice

    Energy Technology Data Exchange (ETDEWEB)

    Hamrick, Mark W., E-mail: mhamrick@mail.mcg.edu [Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Department of Orthopaedic Surgery, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Herberg, Samuel; Arounleut, Phonepasong [Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Department of Orthopaedic Surgery, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); He, Hong-Zhi [Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI (United States); Department of Dermatology, Henry Ford Health System, Detroit, MI (United States); Shiver, Austin [Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Department of Orthopaedic Surgery, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Qi, Rui-Qun [Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI (United States); Department of Dermatology, Henry Ford Health System, Detroit, MI (United States); Zhou, Li [Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI (United States); Department of Dermatology, Henry Ford Health System, Detroit, MI (United States); Department of Internal Medicine, Henry Ford Health System, Detroit, MI (United States); Isales, Carlos M. [Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Department of Orthopaedic Surgery, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); and others

    2010-09-24

    Research highlights: {yields} Aging is associated with muscle atrophy and loss of muscle mass, known as the sarcopenia of aging. {yields} We demonstrate that age-related muscle atrophy is associated with marked changes in miRNA expression in muscle. {yields} Treating aged mice with the adipokine leptin significantly increased muscle mass and the expression of miRNAs involved in muscle repair. {yields} Recombinant leptin therapy may therefore be a novel approach for treating age-related muscle atrophy. -- Abstract: Age-associated loss of muscle mass, or sarcopenia, contributes directly to frailty and an increased risk of falls and fractures among the elderly. Aged mice and elderly adults both show decreased muscle mass as well as relatively low levels of the fat-derived hormone leptin. Here we demonstrate that loss of muscle mass and myofiber size with aging in mice is associated with significant changes in the expression of specific miRNAs. Aging altered the expression of 57 miRNAs in mouse skeletal muscle, and many of these miRNAs are now reported to be associated specifically with age-related muscle atrophy. These include miR-221, previously identified in studies of myogenesis and muscle development as playing a role in the proliferation and terminal differentiation of myogenic precursors. We also treated aged mice with recombinant leptin, to determine whether leptin therapy could improve muscle mass and alter the miRNA expression profile of aging skeletal muscle. Leptin treatment significantly increased hindlimb muscle mass and extensor digitorum longus fiber size in aged mice. Furthermore, the expression of 37 miRNAs was altered in muscles of leptin-treated mice. In particular, leptin treatment increased the expression of miR-31 and miR-223, miRNAs known to be elevated during muscle regeneration and repair. These findings suggest that aging in skeletal muscle is associated with marked changes in the expression of specific miRNAs, and that nutrient

  6. Evolution of Nova TrA 2008 into a High Mass-Accretion Rate Post-Nova

    Science.gov (United States)

    Walter, Frederick M.

    2015-06-01

    NR TrA (Nova TrA 2008) was a normal slow Fe II novae for its first year of evolution. During its third year eclipses appeared, and optical spectra revealed the presence of hot permitted lines of C IV, N V, and O VI in addition to the usual nebular lines. The light curve and spectra resemble those of the V Sge stars. The orbital period is 5.25 hours. The time-resolved spectra show a prominent S-wave in the hot lines with an amplitude of about 100 km/s. We conclude that the system is a CV with a high mass accretion rate that has persisted for some 6 years after the explosion.

  7. On the transition to self-gravity in low mass AGN and YSO accretion discs

    CERN Document Server

    Huré, J M

    2000-01-01

    The equations governing the vertical structure of a stationary keplerian accretion disc are presented. The model is based on the alpha-viscosity, includes self-gravity, convective transport and turbulent pressure. A few properties of the model are discussed for circumstellar and AGN discs. We show the strong sensitivity of the disc structure to the viscous energy deposition towards the vertical axis, specially when entering inside the self-gravitating part of the disc. The local version of the alpha-prescription leads to a "singular" behavior which is also predicted by the vertically averaged model. With respect, a much softer transition is observed with the "alpha-P" formalism. Turbulent pressure is important only for alpha > 0.1. It lowers vertical density gradients, significantly thickens the disc, tends to wash out density inversions and pushes the self-gravitating region to slightly larger radii. Curves localizing the inner edge of the self-gravitating disc as functions of the viscosity parameter and acc...

  8. Association of lower limb muscle mass and energy expenditure with visceral fat mass in healthy men

    OpenAIRE

    Yagi, S.; Kadota, M; Aihara, K; Nishikawa, K.; Hara, T.; Ise, T.; Ueda, Y; Iwase, T; Akaike, M; Shimabukuro, M; Katoh, S.; Sata, M

    2014-01-01

    Background A high-calorie diet and physical inactivity, an imbalance between caloric intake and energy consumption, are major causes of metabolic syndrome (MetS), which manifests as accumulation of visceral fat and insulin resistance. However, the lifestyle-related factors associated with visceral fat mass in healthy men are not fully understood. Methods We evaluated visceral fat area (VFA), skeletal muscle mass, caloric intake, and energy expenditure in 67 healthy male participants (mean age...

  9. Role of muscle mass on sprint performance: gender differences?

    Science.gov (United States)

    Perez-Gomez, Jorge; Rodriguez, German Vicente; Ara, Ignacio; Olmedillas, Hugo; Chavarren, Javier; González-Henriquez, Juan Jose; Dorado, Cecilia; Calbet, José A L

    2008-04-01

    The aim of this study was to determine if gender differences in muscle mass explain the gender differences in running and cycling sprint performance. Body composition (dual-energy X-ray absorptiometry), and running (30 and 300 m test) and cycling (Wingate test) sprint performance were assessed in 123 men and 32 women. Peak power (PP) output in the Wingate test expressed per kg of lower extremities lean mass (LM) was similar in males and females (50.4 +/- 5.6 and 50.5 +/- 6.2 W kg(-1), P = 0.88). No gender differences were observed in the slope of the linear relation between LM and PP or mean power output (MP). However, when MP was expressed per kg of LM, the males attained a 22% higher value (26.6 +/- 3.4 and 21.9 +/- 3.2 W kg(-1), P sprints, even when expressed as a percentage of the whole body mass.

  10. X-Shooter spectroscopy of young stellar objects: IV -- Accretion in low-mass stars and sub-stellar objects in Lupus

    CERN Document Server

    Alcalá, J M; Manara, C F; Spezzi, L; Stelzer, B; Frasca, A; Biazzo, K; Covino, E; Randich, S; Rigliaco, E; Testi, L; Comerón, F; Cupani, G; D'Elia, V

    2013-01-01

    We present X-Shooter/VLT observations of a sample of 36 accreting low-mass stellar and sub-stellar objects (YSOs) in the Lupus star forming region, spanning a range in mass from ~0.03 to ~1.2Msun, but mostly with 0.1Msun < Mstar < 0.5Msun. Our aim is twofold: firstly, analyse the relationship between excess-continuum and line emission accretion diagnostics, and, secondly, to investigate the accretion properties in terms of the physical properties of the central object. The accretion luminosity (Lacc), and from it the accretion rate (Macc), is derived by modelling the excess emission, from the UV to the near-IR, as the continuum emission of a slab of hydrogen. The flux and luminosity (Ll) of a large number of emission lines of H, He, CaII, etc., observed simultaneously in the range from ~330nm to 2500nm, were computed. The luminosity of all the lines is well correlated with Lacc. We provide empirical relationships between Lacc and the luminosity of 39 emission lines, which have a lower dispersion as comp...

  11. The Accretion of Solar Material onto White Dwarfs: No Mixing with Core Material Implies that the Mass of the White Dwarf is Increasing

    CERN Document Server

    Starrfield, Sumner

    2015-01-01

    Cataclysmic Variables (CVs) are close binary star systems with one component an accreting white dwarf (WD) and the other a larger cooler star that fills its Roche Lobe. One consequence of the WDs accreting material, is the possibility that they are growing in mass and will eventually reach the Chandrasekhar Limit. This evolution could result in a Supernova Ia (SN Ia) explosion and is designated the Single Degenerate Progenitor (SD) scenario. One problem with the single degenerate scenario is that it is generally assumed that the accreting material mixes with WD core material at some time during the accretion phase of evolution and, since the typical WD has a carbon-oxygen (CO) core, the mixing results in large amounts of carbon and oxygen being brought up into the accreted layers. The presence of enriched carbon causes enhanced nuclear fusion and a Classical Nova (CN)explosion. Thus, the WD in a Classical Nova system is decreasing in mass and cannot be a SN Ia progenitor. In new calculations reported here, th...

  12. Conditions for water ice lines and Mars-mass exomoons around accreting super-Jovian planets at 1 - 20 AU from Sun-like stars

    CERN Document Server

    Heller, René

    2015-01-01

    Exomoon detections might be feasible with NASA's Kepler or ESA's upcoming PLATO mission or the ground-based E-ELT. To use observational resources most efficiently we need to know where the largest, most easily detected moons can form. We explore the possibility of large exomoons by following the movement of water (H2O) ice lines in the accretion disks around young super-Jovian planets. We want to know how different heating sources in those disks affect the H2O ice lines. We simulate 2D rotationally symmetric accretion disks in hydrostatic equilibrium around super-Jovian exoplanets. The energy terms in our semi-analytical model -- (1) viscous heating, (2) planetary illumination, (3) accretional heating, and (4) stellar illumination -- are fed by precomputed planet evolution tracks. We consider planets accreting 1 to 12 Jupiter masses at distances between 1 and 20 AU to a Sun-like star. Accretion disks around Jupiter-mass planets closer than ~4.5 AU to Sun-like stars do not feature H2O ice lines, but the most m...

  13. General polytropic self-gravitating cylinder free-fall and accreting mass string with a chain of collapsed objects

    Science.gov (United States)

    Lou, Yu-Qing; Hu, Xu-Yao

    2016-06-01

    We present a theoretical model framework for general polytropic (GP) hydrodynamic cylinder under self-gravity of infinite length with axial uniformity and axisymmetry. For self-similar dynamic solutions, we derive valuable integrals, analytic asymptotic solutions, sonic critical curves, shock conditions, and global numerical solutions with or without expansion shocks. Among others, we investigate various dynamic solutions featured with central free-fall asymptotic behaviours, corresponding to a collapsed mass string with a sustained dynamic accretion from a surrounding mass reservoir. Depending on the allowed ranges of a scaling index a Physically, such a collapsed mass string or filament would break up into a sequence of sub-clumps and segments as induced by gravitational Jeans instabilities. Depending on the scales involved, such sub-clumps would evolve into collapsed objects or gravitationally bound systems. In diverse astrophysical and cosmological contexts, such a scenario can be adapted on various temporal, spatial and mass scales to form a chain of collapsed clumps and/or compact objects. Examples include the formation of chains of proto-stars, brown dwarfs and gaseous planets along molecular filaments; the formation of luminous massive stars along magnetized spiral arms and circum-nuclear starburst rings in barred spiral galaxies; the formation of chains of compact stellar objects such as white dwarfs, neutron stars, and black holes along a highly condensed mass string. On cosmological scales, one can perceive the formation of chains of galaxies, chains of galaxy clusters or even chains of supermassive and hypermassive black holes in the Universe including the early Universe. All these chains referred to above include possible binaries.

  14. Association of low back pain with muscle stiffness and muscle mass of the lumbar back muscles, and sagittal spinal alignment in young and middle-aged medical workers.

    Science.gov (United States)

    Masaki, Mitsuhiro; Aoyama, Tomoki; Murakami, Takashi; Yanase, Ko; Ji, Xiang; Tateuchi, Hiroshige; Ichihashi, Noriaki

    2017-09-14

    Muscle stiffness of the lumbar back muscles in low back pain (LBP) patients has not been clearly elucidated because quantitative assessment of the stiffness of individual muscles was conventionally difficult. This study aimed to examine the association of LBP with muscle stiffness assessed using ultrasonic shear wave elastography (SWE) and muscle mass of the lumbar back muscle, and spinal alignment in young and middle-aged medical workers. The study comprised 23 asymptomatic medical workers [control (CTR) group] and 9 medical workers with LBP (LBP group). Muscle stiffness and mass of the lumbar back muscles (lumbar erector spinae, multifidus, and quadratus lumborum) in the prone position were measured using ultrasonic SWE. Sagittal spinal alignment in the standing and prone positions was measured using a Spinal Mouse. The association with LBP was investigated by multiple logistic regression analysis with a forward selection method. The analysis was conducted using the shear elastic modulus and muscle thickness of the lumbar back muscles, and spinal alignment, age, body height, body weight, and sex as independent variables. Multiple logistic regression analysis showed that muscle stiffness of the lumbar multifidus muscle and body height were significant and independent determinants of LBP, but that muscle mass and spinal alignment were not. Muscle stiffness of the lumbar multifidus muscle in the LBP group was significantly higher than that in the CTR group. The results of this study suggest that LBP is associated with muscle stiffness of the lumbar multifidus muscle in young and middle-aged medical workers. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. Scaling of the photon index vs mass accretion rate correlation and estimate of black hole mass in M101 ULX-1

    CERN Document Server

    Titarchuk, Lev

    2016-01-01

    We report the results of Swift and Chandra observations of an ultra-luminous X-ray source, ULX-1 in M101. We show strong observational evidence that M101 ULX-1 undergoes spectral transitions from the low/hard state to the high/soft state during these observations. The spectra of M101 ULX-1 are well fitted by the so-called bulk motion Comptonization (BMC) model for all spectral states. We have established the photon index (\\Gamma) saturation level, \\Gamma_{sat}=2.8 +/- 0.1, in the \\Gamma vs. mass accretion rate (\\dot M) correlation. This \\Gamma-\\dot M correlation allows us to evaluate black hole (BH) mass in M101 ULX-1 to be M_{BH}~(3.2 - 4.3)x10^4 solar masses assuming the spread in distance to M101 (from 6.4+/- 0.5 Mpc to 7.4+/-0.6 Mpc). For this BH mass estimate we use the scaling method taking Galactic BHs XTE~J1550-564, H~1743-322 and 4U~1630-472 as reference sources. The Gamma vs. \\dot M correlation revealed in M101~ULX-1 is similar to that in a number of Galactic BHs and exhibits clearly the correlation...

  16. ACCRETION ONTO BLACK HOLES FROM LARGE SCALES REGULATED BY RADIATIVE FEEDBACK. III. ENHANCED LUMINOSITY OF INTERMEDIATE-MASS BLACK HOLES MOVING AT SUPERSONIC SPEEDS

    Energy Technology Data Exchange (ETDEWEB)

    Park, KwangHo [McWilliams Center for Cosmology, Carnegie Mellon University, Pittsburgh, PA 15213 (United States); Ricotti, Massimo, E-mail: kpark@astro.umd.edu, E-mail: ricotti@astro.umd.edu [Joint Space-Science Institute (JSI), College Park, MD 20742 (United States)

    2013-04-20

    In this third paper of a series, we study the growth and luminosity of black holes (BHs) in motion with respect to their surrounding medium. We run a large set of two-dimensional axis-symmetric simulations to explore a large parameter space of initial conditions and formulate an analytical model for the accretion. Contrary to the case without radiation feedback, the accretion rate increases with increasing BH velocity v{sub bh} reaching a maximum value at v{sub bh} = 2c{sub s,in} {approx} 50 km s{sup -1}, where c{sub s,in} is the sound speed inside the ''cometary-shaped'' H II region around the BH, before decreasing as v{sub bh}{sup -3} when the ionization front (I-front) becomes R-type (rarefied) and the accretion rate approaches the classical Bondi-Hoyle-Lyttleton solution. The increase of the accretion rate with v{sub bh} is produced by the formation of a D-type (dense) I-front preceded by a standing bow shock that reduces the downstream gas velocity to transonic values. There is a range of densities and velocities where the dense shell is unstable producing periodic accretion rate peaks which can significantly increase the detectability of intermediate-mass BHs. We find that the mean accretion rate for a moving BH is larger than that of a stationary BH of the same mass if the medium temperature is T{sub {infinity}} < 10{sup 4} K. This result could be important for the growth of seed BHs in the multi-phase medium of the first galaxies and for building an early X-ray background that may affect the formation of the first galaxies and the reionization process.

  17. The effect Mat Pilates practice on muscle mass in elderly women

    Directory of Open Access Journals (Sweden)

    Leliz Cristina Sampaio Queiroz

    2016-01-01

    Full Text Available Objective: to verify that the Mat Pilates practice increases muscle mass in elderly women. Methods: quasi-experimental study with primary data collection and with a convenience sample. The muscle mass of 43 elderly was evaluated for 11 weeks, by calculating the arm muscle area, before and after the intervention. Results:statistically significant difference was observed (p<0.002 between the average value of the arm muscle area, before (35.56cm2 and after the exercises (42.72cm2. Conclusion: mat Pilates program generates positive effect on increasing the muscle mass of elderly.

  18. The Magnetospheres of (Accreting Neutron Stars

    Directory of Open Access Journals (Sweden)

    Wilms J.

    2014-01-01

    Full Text Available I give an overview of the most important observational tools to study the magnetospheres of accreting neutron stars, with a focus on accreting neutron stars in high mass X-ray binary systems. Topics covered are the different types of accretion onto neutron stars and the structure of the accretion column, and how models for these can be tested with observations.

  19. Massive star formation by accretion. I. Disc accretion

    Science.gov (United States)

    Haemmerlé, L.; Eggenberger, P.; Meynet, G.; Maeder, A.; Charbonnel, C.

    2016-01-01

    Context. Massive stars likely form by accretion and the evolutionary track of an accreting forming star corresponds to what is called the birthline in the Hertzsprung-Russell (HR) diagram. The shape of this birthline is quite sensitive to the evolution of the entropy in the accreting star. Aims: We first study the reasons why some birthlines published in past years present different behaviours for a given accretion rate. We then revisit the question of the accretion rate, which allows us to understand the distribution of the observed pre-main-sequence (pre-MS) stars in the HR diagram. Finally, we identify the conditions needed to obtain a large inflation of the star along its pre-MS evolution that may push the birthline towards the Hayashi line in the upper part of the HR diagram. Methods: We present new pre-MS models including accretion at various rates and for different initial structures of the accreting core. We compare them with previously published equivalent models. From the observed upper envelope of pre-MS stars in the HR diagram, we deduce the accretion law that best matches the accretion history of most of the intermediate-mass stars. Results: In the numerical computation of the time derivative of the entropy, some treatment leads to an artificial loss of entropy and thus reduces the inflation that the accreting star undergoes along the birthline. In the case of cold disc accretion, the existence of a significant swelling during the accretion phase, which leads to radii ≳ 100 R⊙ and brings the star back to the red part of the HR diagram, depends sensitively on the initial conditions. For an accretion rate of 10-3M⊙ yr-1, only models starting from a core with a significant radiative region evolve back to the red part of the HR diagram. We also obtain that, in order to reproduce the observed upper envelope of pre-MS stars in the HR diagram with an accretion law deduced from the observed mass outflows in ultra-compact HII regions, the fraction of the

  20. Viscosity parameter in dissipative accretion flows with mass outflow around black holes

    Science.gov (United States)

    Nagarkoti, Shreeram; Chakrabarti, Sandip K.

    2016-10-01

    Numerical hydrodynamic simulation of inviscid and viscous flows have shown that significant outflows could be produced from the CENtrifugal pressure-supported BOundary Layer or CENBOL of an advective disc. However, this barrier is weakened in presence of viscosity, more so, if there are explicit energy dissipations at the boundary layer itself. We study effects of viscosity and energy dissipation theoretically on the outflow rate and show that, as the viscosity or energy dissipation (or both) rises, the prospect of formation of outflows is greatly reduced, thereby verifying results obtained through observations and numerical simulations. Indeed, we find that in a dissipative viscous flow, shocks in presence of outflows can be produced only if the Shakura-Sunyaev viscosity parameter α is less than 0.2. This is a direct consequence of modification of the Rankine-Hugoniot relation across the shock in a viscous flow, when the energy dissipation and mass-loss in the form of outflows from the post-shock region are included. If we ignore the effects of mass-loss altogether, the standing dissipative shocks in viscous flows may occur only if α black hole candidates such as GX399-4, MAXI J1659-152 and MAXI J1836-194 and find that required α are indeed well within our prescribed limit.

  1. Reaction of Accretion Disks to Abrupt Mass Loss During Binary Black Hole Merger

    CERN Document Server

    O'Neill, Sean M; Bogdanovic, Tamara; Reynolds, Christopher S; Schnittman, Jeremy

    2008-01-01

    The association of an electromagnetic signal with the merger of a pair of supermassive black holes would have many important implications. For example, it would provide new information about gas and magnetic field interactions in dynamical spacetimes as well as a combination of redshift and luminosity distance that would enable precise cosmological tests. A proposal first made by Bode & Phinney (2007) is that because radiation of gravitational waves during the final inspiral and merger of the holes is abrupt and decreases the mass of the central object by a few percent, there will be waves in the disk that can steepen into shocks and thus increase the disk luminosity in a characteristic way. We evaluate this process analytically and numerically. We find that shocks only occur when the fractional mass loss exceeds the half-thickness (h/r) of the disk, hence significant energy release only occurs for geometrically thin disks which are thus at low Eddington ratios. This strongly limits the effective energy r...

  2. A Method for Black Hole Mass Determination in Accretion Powered X-Ray Sources

    CERN Document Server

    Shrader, C R; Shrader, Chris; Titarchuk, Lev

    2003-01-01

    We describe a method for the determination of black-hole masses based on information inferred from high-energy spectra. It is required that the spectral energy distribution consist of thermal and Comptonized components. One can then, in principle, infer the depth of the gravitational potential well for sources of known distance. The thermal component is inferred by the integration of a blackbody spectral form over the disk. We assume that the color temperature distribution in the disk has a specific shape given by the Shakura-Sunyaev (1973) disk model which goes to zero at the inner disk radius and at infinity and has a maximum at 4.2 Schwarzchild radii. In this formulation there is only one parameter, the so called color correction factor, relating the apparent temperature to effective temperature which characterizes the thermal emission component. We have made use of improved Galactic black hole binary dynamical mass determinations to derive, in effect, an empirical calibration of this factor. We then prese...

  3. Ultraluminous X-ray Sources Powered by Radiatively Efficient Two-Phased Super-Eddington Accretion onto Stellar Mass Black holes

    CERN Document Server

    Socrates, A; Socrates, Aristotle; Davis, Shane W.

    2005-01-01

    The radiation spectra of many of the brightest ultraluminous X-ray sources (ULXs) are dominated by a hard power law component, likely powered by a hot, optically thin corona that Comptonizes soft seed photons emitted from a cool, optically thick black hole accretion disk. Before its dissipation and subsequent conversion into coronal photon power, the randomized gravitational binding energy responsible for powering ULX phenomena must separate from the mass of its origin by a means other than, and quicker than, electron scattering-mediated radiative diffusion. Therefore, the release of accretion power in ULXs is not necessarily subject to Eddington-limited photon trapping, as long as it occurs in a corona. Motivated by these basic considerations, we present a model of ULXs powered by geometrically thin accretion onto stellar mass black holes. We argue that the radiative efficiency of the flow remains high if the corona is magnetized or optically thin and the majority of the accretion power escapes in the form o...

  4. An accretion disks in the high-mass star forming region IRA 23151+5912

    Science.gov (United States)

    Migenes, Victor; Rodríguez-Esnard, T.; Trinidad, M. A.

    2014-01-01

    We present observations of radio continuum emission at 1.3 and 3.6 cm and H2O masers toward the high-mass star-forming regions IRA 23151+5912 carried out with the VLA-EVLA. We detected one continuum source at 1.3 cm and 13 water maser spots which are distributed in three groups aligned along the northeast-southwest direction. Our results suggest that the 1.3 cm emission is consistent with an HC HII region, probably with an embedded zero-age main sequence star of type B2. In particular, we find that this radio continuum source is probably associated with a circumstellar disk of about 68 AU, as traced by water masers. Furthermore, the masers of the second group are probably describing another circumstellar disk of about 86 AU, whose central protostar is still undetected. We discuss this results in the light of more recent high-resolution observations.

  5. The SW Sex-type star 2MASS J01074282+4845188: an unusual bright accretion disk with non-steady emission and a hot white dwarf

    CERN Document Server

    Khruzina, T; Kjurkchieva, D; 10.1051/0004-6361/201220385

    2013-01-01

    We present new photometric and spectral observations of the newly discovered nova-like eclipsing star 2MASS J01074282+4845188. To obtain a light curve solution we used model of a nova-like star whose emission sources are a white dwarf surrounded by an accretion disk, a secondary star filling its Roche lobe, a hot spot and a hot line. 2MASS J01074282+4845188 shows the deepest permanent eclipse among the known nova-like stars. It is reproduced by covering the very bright accretion disk by the secondary component. The luminosity of the disk is much bigger than that of the rest light sources. The determined high temperature of the disk is typical for that observed during the outbursts of CVs. The primary of 2MASS J01074282+4845188 is one of the hottest white dwarfs in CVs. The temperature of 5090 K of its secondary is also quite high and more appropriate for a long-period SW Sex star. It might be explained by the intense heating from the hot white dwarf and the hot accretion disk of the target. The high mass accr...

  6. Supplemental protein in support of muscle mass and health: advantage whey.

    Science.gov (United States)

    Devries, Michaela C; Phillips, Stuart M

    2015-03-01

    Skeletal muscle is an integral body tissue playing key roles in strength, performance, physical function, and metabolic regulation. It is essential for athletes to ensure that they have optimal amounts of muscle mass to ensure peak performance in their given sport. However, the role of maintaining muscle mass during weight loss and as we age is an emerging concept, having implications in chronic disease prevention, functional capacity, and quality of life. Higher-protein diets have been shown to: (1) promote gains in muscle mass, especially when paired with resistance training; (2) spare muscle mass loss during caloric restriction; and (3) attenuate the natural loss of muscle mass that accompanies aging. Protein quality is important to the gain and maintenance of muscle mass. Protein quality is a function of protein digestibility, amino acid content, and the resulting amino acid availability to support metabolic function. Whey protein is one of the highest-quality proteins given its amino acid content (high essential, branched-chain, and leucine amino acid content) and rapid digestibility. Consumption of whey protein has a robust ability to stimulate muscle protein synthesis. In fact, whey protein has been found to stimulate muscle protein synthesis to a greater degree than other proteins such as casein and soy. This review examines the existing data supporting the role for protein consumption, with an emphasis on whey protein, in the regulation of muscle mass and body composition in response to resistance training, caloric restriction, and aging.

  7. Viscosity parameter in dissipative accretion flows with mass outflow around black holes

    CERN Document Server

    Nagarkoti, Shreeram

    2016-01-01

    Numerical hydrodynamic simulation of inviscid and viscous flows have shown that significant outflows could be produced from the CENtrifugal pressure supported BOundary Layer or CENBOL of an advective disk. However, this barrier is weakened in presence of viscosity, more so, if there are explicit energy dissipations at the boundary layer itself. We study effects of viscosity and energy dissipation theoretically on the outflow rate and show that as the viscosity or energy dissipation (or both) rises, the prospect of formation of outflows is greatly reduced, thereby verifying results obtained through observations and numerical simulations. Indeed, we find that in a dissipative viscous flow, shocks in presence of outflows can be produced only if the Shakura-Sunyaev viscosity parameter {\\alpha} is less than 0.2. This is a direct consequence of modification of the Rankine-Hugoniot relation across the shock in a viscous flow, when the energy dissipation and mass loss in the form of outflows from the post-shock regio...

  8. A New Equation to Estimate Muscle Mass from Creatinine and Cystatin C.

    Directory of Open Access Journals (Sweden)

    Sun-wook Kim

    Full Text Available With evaluation for physical performance, measuring muscle mass is an important step in detecting sarcopenia. However, there are no methods to estimate muscle mass from blood sampling.To develop a new equation to estimate total-body muscle mass with serum creatinine and cystatin C level, we designed a cross-sectional study with separate derivation and validation cohorts. Total body muscle mass and fat mass were measured using dual-energy x-ray absorptiometry (DXA in 214 adults aged 25 to 84 years who underwent physical checkups from 2010 to 2013 in a single tertiary hospital. Serum creatinine and cystatin C levels were also examined.Serum creatinine was correlated with muscle mass (P < .001, and serum cystatin C was correlated with body fat mass (P < .001 after adjusting glomerular filtration rate (GFR. After eliminating GFR, an equation to estimate total-body muscle mass was generated and coefficients were calculated in the derivation cohort. There was an agreement between muscle mass calculated by the novel equation and measured by DXA in both the derivation and validation cohort (P < .001, adjusted R2 = 0.829, β = 0.95, P < .001, adjusted R2 = 0.856, β = 1.03, respectively.The new equation based on serum creatinine and cystatin C levels can be used to estimate total-body muscle mass.

  9. Magnetized accretion

    Science.gov (United States)

    Heyvaerts, J.

    This lecture reviews in simple terms the general subject of large scale magnetic field coupling to plasma flows in the vicinity of accreting compact stars. The relevant astrophysical phenomenology is summarized. Disk interaction with the magnetosphere of accreting stars is first discussed, in particular the structure of the magnetopause, its stability and plasma ejection in so-called propeller systems. The physics of accretion/ejection is then considered. Acceleration and focusing mechanisms of jets from accretion disks around compact stars or black holes and the question of the self-consistency of accretion and ejection are described. By contrast, small scale MHD turbulence in disks is not discussed, neither are accretion columns near the polar caps of neutron stars or white dwarfs. The reader is only assumed to have some basic knowledge of astrophysics and of fluid mechanics and electromagnetism.

  10. Near-Infrared Spectroscopy of Low Mass X-ray Binaries : Accretion Disk Contamination and Compact Object Mass Determination in V404 Cyg and Cen X-4

    CERN Document Server

    Khargharia, Juthika; Robinson, Edward L

    2010-01-01

    We present near-infrared (NIR) broadband (0.80--2.42 $\\mu$m) spectroscopy of two low mass X-ray binaries: V404 Cyg and Cen X-4. One important parameter required in the determination of the mass of the compact objects in these systems is the binary inclination. We can determine the inclination by modeling the ellipsoidal modulations of the Roche-lobe filling donor star, but the contamination of the donor star light from other components of the binary, particularly the accretion disk, must be taken into account. To this end, we determined the donor star contribution to the infrared flux by comparing the spectra of V404 Cyg and Cen X-4 to those of various field K-stars of known spectral type. For V404 Cyg, we determined that the donor star has a spectral type of K3 III. We determined the fractional donor contribution to the NIR flux in the H- and K-bands as $0.98 \\pm .05$ and $0.97 \\pm .09$, respectively. We remodeled the H-band light curve from \\citet{sanwal1996} after correcting for the donor star contribution...

  11. Impact of initial models and variable accretion rates on the pre-main-sequence evolution of massive and intermediate-mass stars and the early evolution of HII regions

    CERN Document Server

    Haemmerlé, Lionel

    2016-01-01

    Massive star formation requires the accretion of gas at high rate while the star is already bright. Its actual luminosity depends sensitively on the stellar structure. We compute pre-main-sequence tracks for massive and intermediate-mass stars with variable accretion rates and study the evolution of stellar radius, effective temperature and ionizing luminosity, starting at $2\\,M_\\odot$ with convective or radiative structures. The radiative case shows a much stronger swelling of the protostar for high accretion rates than the convective case. For radiative structures, the star is very sensitive to the accretion rate and reacts quickly to accretion bursts, leading to considerable changes in photospheric properties on timescales as short as 100 - 1000 yr. The evolution for convective structures is much less influenced by the instantaneous accretion rate, and produces a monotonically increasing ionizing flux that can be many orders of magnitude smaller than in the radiative case. For massive stars, it results in ...

  12. Non-Hodgkin lymphoma in skeletal muscle manifesting as homogeneous masses with CT attenuation similar to muscle

    Energy Technology Data Exchange (ETDEWEB)

    Panicek, D.M.; Lautin, J.L.; Schwartz, L.H.; Castellino, R.A. [Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 (United States)

    1997-11-01

    Two cases are presented of masses in muscle due to non-Hodgkin lymphoma (NHL) that were homogeneous and isoattenuating to normal muscle on CT. In each case, the mass was clinically suspected of representing soft tissue sarcoma. However, the masses were relatively inapparent on CT, being visible predominantly as mass effect - an appearance unlike that of soft tissue sarcomas. It is important to be aware that NHL in muscle can be difficult to detect at CT, even with intravenous contrast enhancement; therefore, a clinically apparent mass should not be dismissed on the basis of an apparently unremarkable CT scan of the region. Such findings should suggest the diagnosis of NHL rather than sarcoma. (orig.) With 2 figs., 7 refs.

  13. Avian pectoral muscle size rapidly tracks body mass changes during flight, fasting and fuelling.

    Science.gov (United States)

    Lindström, A; Kvist, A; Piersma, T; Dekinga, A; Dietz, M W

    2000-03-01

    We used ultrasonic imaging to monitor short-term changes in the pectoral muscle size of captive red knots Calidris canutus. Pectoral muscle thickness changed rapidly and consistently in parallel with body mass changes caused by flight, fasting and fuelling. Four knots flew repeatedly for 10 h periods in a wind tunnel. Over this period, pectoral muscle thickness decreased in parallel with the decrease in body mass. The change in pectoral muscle thickness during flight was indistinguishable from that during periods of natural and experimental fasting and fuelling. The body-mass-related variation in pectoral muscle thickness between and within individuals was not related to the amount of flight, indicating that changes in avian muscle do not require power-training as in mammals. Our study suggests that it is possible for birds to consume and replace their flight muscles on a time scale short enough to allow these muscles to be used as part of the energy supply for migratory flight. The adaptive significance of the changes in pectoral muscle mass cannot be explained by reproductive needs since our knots were in the early winter phase of their annual cycle. Instead, pectoral muscle mass changes may reflect (i) the breakdown of protein during heavy exercise and its subsequent restoration, (ii) the regulation of flight capacity to maintain optimal flight performance when body mass varies, or (iii) the need for a particular protein:fat ratio in winter survival stores.

  14. Maintenance of muscle mass and load-induced growth in Muscle RING Finger 1 null mice with age.

    Science.gov (United States)

    Hwee, Darren T; Baehr, Leslie M; Philp, Andrew; Baar, Keith; Bodine, Sue C

    2014-02-01

    Age-related loss of muscle mass occurs to varying degrees in all individuals and has a detrimental effect on morbidity and mortality. Muscle RING Finger 1 (MuRF1), a muscle-specific E3 ubiquitin ligase, is believed to mediate muscle atrophy through the ubiquitin proteasome system (UPS). Deletion of MuRF1 (KO) in mice attenuates the loss of muscle mass following denervation, disuse, and glucocorticoid treatment; however, its role in age-related muscle loss is unknown. In this study, skeletal muscle from male wild-type (WT) and MuRF1 KO mice was studied up to the age of 24 months. Muscle mass and fiber cross-sectional area decreased significantly with age in WT, but not in KO mice. In aged WT muscle, significant decreases in proteasome activities, especially 20S and 26S β5 (20-40% decrease), were measured and were associated with significant increases in the maladaptive endoplasmic reticulum (ER) stress marker, CHOP. Conversely, in aged MuRF1 KO mice, 20S or 26S β5 proteasome activity was maintained or decreased to a lesser extent than in WT mice, and no increase in CHOP expression was measured. Examination of the growth response of older (18 months) mice to functional overload revealed that old WT mice had significantly less growth relative to young mice (1.37- vs. 1.83-fold), whereas old MuRF1 KO mice had a normal growth response (1.74- vs. 1.90-fold). These data collectively suggest that with age, MuRF1 plays an important role in the control of skeletal muscle mass and growth capacity through the regulation of cellular stress. © 2013 the Anatomical Society and John Wiley & Sons Ltd.

  15. The Intriguing Regulators of Muscle Mass in Sarcopenia and Muscular Dystrophy

    OpenAIRE

    Sakuma, Kunihiro; Aoi, Wataru; Yamaguchi, Akihiko

    2014-01-01

    Recent advances in our understanding of the biology of muscle have led to new interest in the pharmacological treatment of muscle wasting. Loss of muscle mass and increased intramuscular fibrosis occur in both sarcopenia and muscular dystrophy. Several regulators (mammalian target of rapamycin, serum response factor, atrogin-1, myostatin, etc.) seem to modulate protein synthesis and degradation or transcription of muscle-specific genes during both sarcopenia and muscular dystrophy. This revie...

  16. Photoperiod regulates lean mass accretion, but not adiposity, in growing F344 rats fed a high fat diet.

    Directory of Open Access Journals (Sweden)

    Alexander W Ross

    Full Text Available In this study the effects of photoperiod and diet, and their interaction, were examined for their effects on growth and body composition in juvenile F344 rats over a 4-week period. On long (16L:8D, relative to short (8L:16D, photoperiod food intake and growth rate were increased, but percentage adiposity remained constant (ca 3-4%. On a high fat diet (HFD, containing 22.8% fat (45% energy as fat, food intake was reduced, but energy intake increased on both photoperiods. This led to a small increase in adiposity (up to 10% without overt change in body weight. These changes were also reflected in plasma leptin and lipid levels. Importantly while both lean and adipose tissue were strongly regulated by photoperiod on a chow diet, this regulation was lost for adipose, but not lean tissue, on HFD. This implies that a primary effect of photoperiod is the regulation of growth and lean mass accretion. Consistent with this both hypothalamic GHRH gene expression and serum IGF-1 levels were photoperiod dependent. As for other animals and humans, there was evidence of central hyposomatotropism in response to obesity, as GHRH gene expression was suppressed by the HFD. Gene expression of hypothalamic AgRP and CRH, but not NPY nor POMC, accorded with the energy balance status on long and short photoperiod. However, there was a general dissociation between plasma leptin levels and expression of these hypothalamic energy balance genes. Similarly there was no interaction between the HFD and photoperiod at the level of the genes involved in thyroid hormone metabolism (Dio2, Dio3, TSHβ or NMU, which are important mediators of the photoperiodic response. These data suggest that photoperiod and HFD influence body weight and body composition through independent mechanisms but in each case the role of the hypothalamic energy balance genes is not predictable based on their known function.

  17. Nucleoprotein supplementation enhances the recovery of rat soleus mass with reloading after hindlimb unloading-induced atrophy via myonuclei accretion and increased protein synthesis.

    Science.gov (United States)

    Nakanishi, Ryosuke; Hirayama, Yusuke; Tanaka, Minoru; Maeshige, Noriaki; Kondo, Hiroyo; Ishihara, Akihiko; Roy, Roland R; Fujino, Hidemi

    2016-12-01

    Hindlimb unloading results in muscle atrophy and a period of reloading has been shown to partially recover the lost muscle mass. Two of the mechanisms involved in this recovery of muscle mass are the activation of protein synthesis pathways and an increase in myonuclei number. The additional myonuclei are provided by satellite cells that are activated by the mechanical stress associated with the reloading of the muscles and eventually incorporated into the muscle fibers. Amino acid supplementation with exercise also can increase skeletal muscle mass through enhancement of protein synthesis and nucleotide supplements can promote cell cycle activity. Therefore, we hypothesized that nucleoprotein supplementation, a combination of amino acids and nucleotides, would enhance the recovery of muscle mass to a greater extent than reloading alone after a period of unloading. Adult rats were assigned to 4 groups: control, hindlimb unloaded (HU; 14 days), reloaded (5 days) after hindlimb unloading (HUR), and reloaded after hindlimb unloading with nucleoprotein supplementation (HUR + NP). Compared with the HUR group, the HUR + NP group had larger soleus muscles and fiber cross-sectional areas, higher levels of phosphorylated rpS6, and higher numbers of myonuclei and myogenin-positive cells. These results suggest that nucleoprotein supplementation has a synergistic effect with reloading in recovering skeletal muscle properties after a period of unloading via rpS6 activation and satellite cell differentiation and incorporation into the muscle fibers. Therefore, this supplement may be an effective therapeutic regimen to include in rehabilitative strategies for a variety of muscle wasting conditions such as aging, cancer cachexia, muscular dystrophy, bed rest, and cast immobilization. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Bio-impedance analysis for appendicular skeletal muscle mass assessment in (pre-) frail elderly people

    NARCIS (Netherlands)

    Baar, van H.; Hulshof, P.J.M.; Tieland, C.A.B.; Groot, de C.P.G.M.

    2015-01-01

    Background & aims Screening populations for skeletal muscle mass (SMM) is important for early detection of sarcopenia. Our aim was to develop an age specific bio-impedance (BI) prediction equation for the assessment of appendicular skeletal muscle mass (ASMM) in (pre-) frail elderly people aged

  19. Black hole accretion discs

    CERN Document Server

    Lasota, Jean-Pierre

    2015-01-01

    This is an introduction to models of accretion discs around black holes. After a presentation of the non-relativistic equations describing the structure and evolution of geometrically thin accretion discs we discuss their steady-state solutions and compare them to observation. Next we describe in detail the thermal-viscous disc instability model and its application to dwarf novae for which it was designed and its X-ray irradiated-disc version which explains the soft X--ray transients, i.e. outbursting black-hole low-mass X-ray binaries. We then turn to the role of advection in accretion flow onto black holes illustrating its action and importance with a toy model describing both ADAFs and slim discs. We conclude with a presentation of the general-relativistic formalism describing accretion discs in the Kerr space-time.

  20. PGC-1α is important for maintaining the balance of muscle mass and myofiber types in unloaded muscle atrophy

    Science.gov (United States)

    Chen, Xiaoping; He, Jian; Wang, Fei; Zhang, Peng; Liu, Hongju; Li, Wenjiong

    2016-07-01

    PGC-1α, a transcriptional co-activator, has been shown mainly to determine the development of oxidative myofibers in skeletal muscle. However, whether PGC-1α functions to regulate the unloaded muscle atrophy and composition of myofiber types keeps unclear. MCK-PGC-1α overexpression transgenic mice (TG) and its wild type littermates (WT) were subjected to hindlimb unloading (HU) and induced unloaded muscle atrophy. After 14 days of HU, the mass of gastrocnemius, soleus, and plantaris muscles in WT mice decreased 17.9%, 28.2%, and 14.8%, respectively (Preal-time PCR and Western blot analysis confirmed that PGC-1α overexpression mice markedly rescued the muscle atrophy and myofiber switching from oxidative to glycolytic associated with a decrease in pSmad3 level after 14 days of HU. Importantly, overexpression of PGC-1α in C2C12 myoblasts protected PGC-1α-transfected myotubes from atrophy in vitro and the effect could be partially blocked by inducing pSmad3 with constitutively activated Smad3(C.A. smad3) transfection. Therefore, this study demonstrated a novel role and mechanism for PGC-1α in maintaining the balance of muscle mass and myofiber type MHCs in unloaded muscle atrophy via suppressing Smad3 activation. This report may prompt a hopeful therapeutic strategy for maintaining muscle mass and fiber type composition in disused muscle atrophies such as space weightlessness- or immobilization-induced muscle atrophy. Acknowledgments This work was supported by the Natural Sciences Foundation of China (31171144, 81272177 and 31171148), the State Key Laboratory Grant of Space Medicine Fundamentals and Application (SMFA13A01), and the National Key Laboratory Grant of Human Factors Engineering (SYFD140051801).

  1. Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia.

    Science.gov (United States)

    Kim, Kyoung Min; Jang, Hak Chul; Lim, Soo

    2016-07-01

    Aging processes are inevitably accompanied by structural and functional changes in vital organs. Skeletal muscle, which accounts for 40% of total body weight, deteriorates quantitatively and qualitatively with aging. Skeletal muscle is known to play diverse crucial physical and metabolic roles in humans. Sarcopenia is a condition characterized by significant loss of muscle mass and strength. It is related to subsequent frailty and instability in the elderly population. Because muscle tissue is involved in multiple functions, sarcopenia is closely related to various adverse health outcomes. Along with increasing recognition of the clinical importance of sarcopenia, several international study groups have recently released their consensus on the definition and diagnosis of sarcopenia. In practical terms, various skeletal muscle mass indices have been suggested for assessing sarcopenia: appendicular skeletal muscle mass adjusted for height squared, weight, or body mass index. A different prevalence and different clinical implications of sarcopenia are highlighted by each definition. The discordances among these indices have emerged as an issue in defining sarcopenia, and a unifying definition for sarcopenia has not yet been attained. This review aims to compare these three operational definitions and to introduce an optimal skeletal muscle mass index that reflects the clinical implications of sarcopenia from a metabolic perspective.

  2. Accretion physics: It's not U, it's B

    Science.gov (United States)

    Miller, Jon

    2017-03-01

    Black holes grow by accreting mass, but the process is messy and redistributes gas and energy into their environments. New evidence shows that magnetic processes mediate both the accretion and ejection of matter.

  3. Growth hormone mitigates loss of periosteal bone formation and muscle mass in disuse osteopenic rats

    DEFF Research Database (Denmark)

    Grubbe, M-C; Thomsen, Jesper Skovhus; Nyengaard, J R

    2014-01-01

    Growth hormone (GH) is a potent anabolic agent capable of increasing both bone and muscle mass. The aim was to investigate whether GH could counteract disuse-induced loss of bone and muscle mass in a rat model. Paralysis was induced by injecting 4 IU Botox (BTX) into the muscles of the right hind......BMD, -13%, Pmuscle mass (-69%, Pmuscle cell cross sectional area (CSA) (-73%, P... of periosteal BFR/BS (2-fold increase vs. BTX, Pmuscle mass (+29% vs. BTX, Pmuscle CSA (+11%, P=0.064). In conclusion, GH mitigates disuse...

  4. New roles for Smad signaling and phosphatidic acid in the regulation of skeletal muscle mass.

    Science.gov (United States)

    Goodman, Craig A; Hornberger, Troy A

    2014-01-01

    Skeletal muscle is essential for normal bodily function and the loss of skeletal muscle (i.e. muscle atrophy/wasting) can have a major impact on mobility, whole-body metabolism, disease resistance, and quality of life. Thus, there is a clear need for the development of therapies that can prevent the loss, or increase, of skeletal muscle mass. However, in order to develop such therapies, we will first have to develop a thorough understanding of the molecular mechanisms that regulate muscle mass. Fortunately, our knowledge is rapidly advancing, and in this review, we will summarize recent studies that have expanded our understanding of the roles that Smad signaling and the synthesis of phosphatidic acid play in the regulation of skeletal muscle mass.

  5. Muscle mass and function after total hip arthroplasty

    OpenAIRE

    Rasch, Anton

    2009-01-01

    Osteoarthritis (OA) of the hip is a common disease among elderly causing pain, joint stiffness and reduced mobility. Outcome studies have shown total hip arthroplasy (THA) to be a successful surgical procedure. Studies of muscle strength and function after THA are more scarce and results vary. It has been suggested that unloading of the OA limb due to pain, results in hip and thigh muscle weakness and atrophy causing an abnormal gait and impaired postural control. Muscle atr...

  6. New roles for Smad signaling and phosphatidic acid in the regulation of skeletal muscle mass

    OpenAIRE

    Goodman, Craig A.; Hornberger, Troy A.

    2014-01-01

    Skeletal muscle is essential for normal bodily function and the loss of skeletal muscle (i.e. muscle atrophy/wasting) can have a major impact on mobility, whole-body metabolism, disease resistance, and quality of life. Thus, there is a clear need for the development of therapies that can prevent the loss, or increase, of skeletal muscle mass. However, in order to develop such therapies, we will first have to develop a thorough understanding of the molecular mechanisms that regulate muscle mas...

  7. New roles for Smad signaling and phosphatidic acid in the regulation of skeletal muscle mass

    OpenAIRE

    Goodman, Craig A.; Hornberger, Troy A.

    2014-01-01

    Skeletal muscle is essential for normal bodily function and the loss of skeletal muscle (i.e. muscle atrophy/wasting) can have a major impact on mobility, whole-body metabolism, disease resistance, and quality of life. Thus, there is a clear need for the development of therapies that can prevent the loss, or increase, of skeletal muscle mass. However, in order to develop such therapies, we will first have to develop a thorough understanding of the molecular mechanisms that regulate muscle mas...

  8. Regulation of skeletal muscle oxidative capacity and muscle mass by SIRT3

    Science.gov (United States)

    We have previously reported that the expression of mitochondrial deacetylase SIRT3 is high in the slow oxidative muscle and that the expression of muscle SIRT3 level is increased by dietary restriction or exercise training. To explore the function of SIRT3 in skeletal muscle, we report here the esta...

  9. A mass-length scaling law for modeling muscle strength in the lower limb.

    Science.gov (United States)

    Correa, Tomas A; Pandy, Marcus G

    2011-11-10

    Musculoskeletal computer models are often used to study muscle function in children with and without impaired mobility. Calculations of muscle forces depend in part on the assumed strength of each muscle, represented by the peak isometric force parameter, which is usually based on measurements obtained from cadavers of adult donors. The aim of the present study was twofold: first, to develop a method for scaling lower-limb peak isometric muscle forces in typically-developing children; and second, to determine the effect of this scaling method on model calculations of muscle forces obtained for normal gait. Muscle volumes were determined from magnetic resonance (MR) images obtained from ten children aged from 7 to 13yr. A new mass-length scaling law was developed based on the assumption that muscle volume and body mass are linearly related, which was confirmed by the obtained volume and body mass data. Two musculoskeletal models were developed for each subject: one in which peak isometric muscle forces were estimated using the mass-length scaling law; and another in which these parameters were determined directly from the MR-derived muscle volumes. Musculoskeletal modeling and quantitative gait analysis were then used to calculate lower-limb muscle forces in normal walking. The patterns of muscle forces predicted by the model with scaled peak isometric force values were similar to those predicted by the MR-based model, implying that assessments of muscle function obtained from these two methods are practically equivalent. These results support the use of mass-length scaling in the development of subject-specific musculoskeletal models of children.

  10. Protostellar accretion traced with chemistry

    DEFF Research Database (Denmark)

    Frimann, Søren; Jørgensen, Jes K.; Padoan, Paolo;

    2016-01-01

    Context. Understanding how protostars accrete their mass is a centralquestion of star formation. One aspect of this is trying to understandwhether the time evolution of accretion rates in deeply embedded objectsis best characterised by a smooth decline from early to late stages orby intermittent ...

  11. Decreased muscle mass in Korean subjects with intracranial arterial stenosis: The Kangbuk Samsung Health Study.

    Science.gov (United States)

    Jung, Ho-Jung; Jung, Hwanseok; Lee, Taeyoung; Kim, Jongho; Park, Jongsin; Kim, Hacsoo; Cho, Junghwan; Lee, Won-Young; Park, Sung-Woo; Rhee, Eun-Jung; Oh, Hyung-Geun

    2017-01-01

    Intracranial arterial stenosis (ICAS) is a common cause of ischemic stroke in Asians. Decreased muscle mass is one of the major causes of chronic disease in adults. The purpose of this study was to analyze the relationship between muscle mass and ICAS in Korean adults. For this study, we selected a total of 10,530 participants (mean age, 43.3 years; 8558 men) in a health screening program, for whom transcranial Doppler (TCD) ultrasound was used to detect >50% ICAS based on criteria modified from the stroke outcomes and neuroimaging of intracranial atherosclerosis trial. Body composition was evaluated by bioelectrical impedance analysis (BIA). Skeletal muscle index (SMI) was calculated with muscle mass/weight (kg) * 100. Among the total patient population, 322 (3.1%) subjects had ICAS. Subjects with ICAS were older, and had higher mean values for fasting glucose, body mass index and blood pressure compared with those without ICAS. Subjects with ICAS had significantly lower muscle mass, SMI and higher percent body fat compared with those without ICAS. In logistic regression analysis, the subjects in the highest tertile of muscle mass had the lowest odds ratio for ICAS with the lowest tertile group of muscle mass as the reference group even after adjusting for age, systolic blood pressure, fasting blood glucose, sex, smoking and exercise (OR 0.650, 95% CI 0.442-0.955). Subjects with ICAS had significantly decreased muscle mass compared with those without ICAS in Korean adults. The risk for ICAS was lower in subjects with higher muscle mass. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  12. Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients.

    Science.gov (United States)

    Ferrari, Renata; Caram, Laura M O; Faganello, Marcia M; Sanchez, Fernanda F; Tanni, Suzana E; Godoy, Irma

    2015-01-01

    The aim of this study was to investigate the association between systemic inflammatory mediators and peripheral muscle mass and strength in COPD patients. Fifty-five patients (69% male; age: 64±9 years) with mild/very severe COPD (defined as forced expiratory volume in the first second [FEV1] =54%±23%) were evaluated. We evaluated serum concentrations of IL-8, CRP, and TNF-α. Peripheral muscle mass was evaluated by computerized tomography (CT); midthigh cross-sectional muscle area (MTCSA) and midarm cross-sectional muscle area (MACSA) were obtained. Quadriceps, triceps, and biceps strength were assessed through the determination of the one-repetition maximum. The multiple regression results, adjusted for age, sex, and FEV1%, showed positive significant association between MTCSA and leg extension (0.35 [0.16, 0.55]; P=0.001), between MACSA and triceps pulley (0.45 [0.31, 0.58]; P=0.001), and between MACSA and biceps curl (0.34 [0.22, 0.47]; P=0.001). Plasma TNF-α was negatively associated with leg extension (-3.09 [-5.99, -0.18]; P=0.04) and triceps pulley (-1.31 [-2.35, -0.28]; P=0.01), while plasma CRP presented negative association with biceps curl (-0.06 [-0.11, -0.01]; P=0.02). Our results showed negative association between peripheral muscle mass (evaluated by CT) and muscle strength and that systemic inflammation has a negative influence in the strength of specific groups of muscles in individuals with stable COPD. This is the first study showing association between systemic inflammatory markers and strength in upper limb muscles.

  13. Potential cooling of an accretion-heated neutron star crust in the low-mass X-ray binary 1RXS J180408.9-342058

    CERN Document Server

    Parikh, Aastha S; Degenaar, Nathalie; Ootes, Laura S; Page, Dany; Altamirano, Diego; Cackett, Edward M; Deller, Adam T; Gusinskaia, Nina; Hessels, Jason W T; Homan, Jeroen; Linares, Manuel; Miller, Jon M; Miller-Jones, James C A

    2016-01-01

    We have monitored the transient neutron star low-mass X-ray binary 1RXS J180408.9-342058 in quiescence after the end of its ~4.5 month outburst in 2015. The source has been observed 34 times using Swift and once using XMM-Newton in order to study the cooling of an accretion heated neutron star crust. During both the Swift and the XMM-Newton observations the X-ray spectra were dominated by a thermal component. The thermal evolution showed a gradual decay in the X-ray luminosity from ~18x10^32 to ~4x10^32 (D/5.8 kpc)^2 erg s^{-1} and the inferred neutron star surface temperature (for an observer at infinity) decreased from ~100 to ~72 eV between ~8 to ~379 days after the end of outburst. This can be interpreted as cooling of a neutron star crust that had been heated due to accretion during the preceding outburst. Modeling the observed temperature curve with the thermal evolution code NSCool indicated that the source required ~1.9 MeV per accreted nucleon of shallow heating in addition to the standard deep crust...

  14. Deficits in muscle strength, mass, quality and mobility in people with chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Roig, Marc; Eng, Janice J; MacIntyre, Donna L;

    2011-01-01

    strength, mass, and IF were not associated with mobility measures. CONCLUSIONS: Compared with healthy controls, patients with moderate to severe COPD show marked deficits in muscle strength, mass, quality, and mobility. More studies with larger sample size are required to elucidate whether any......PURPOSE: Midthigh intramuscular fat (IF), a feature of reduced muscle quality, is an important predictor of self-reported mobility loss in the elderly. This study compared measures of muscle strength, mass, IF, and mobility in patients with chronic obstructive pulmonary disease (COPD) and healthy...

  15. Potential cooling of an accretion-heated neutron star crust in the low-mass X-ray binary 1RXS J180408.9-342058

    Science.gov (United States)

    Parikh, A. S.; Wijnands, R.; Degenaar, N.; Ootes, L. S.; Page, D.; Altamirano, D.; Cackett, E. M.; Deller, A. T.; Gusinskaia, N.; Hessels, J. W. T.; Homan, J.; Linares, M.; Miller, J. M.; Miller-Jones, J. C. A.

    2017-01-01

    We have monitored the transient neutron star low-mass X-ray binary 1RXS J180408.9-342058 in quiescence after its ˜4.5 month outburst in 2015. The source has been observed using Swift and XMM-Newton. Its X-ray spectra were dominated by a thermal component. The thermal evolution showed a gradual X-ray luminosity decay from ˜18 × 1032 to ˜4 × 1032 (D/5.8 kpc)2 erg s-1 between ˜8 to ˜379 days in quiescence and the inferred neutron star surface temperature (for an observer at infinity; using a neutron star atmosphere model) decreased from ˜100 to ˜71 eV. This can be interpreted as cooling of an accretion heated neutron star crust. Modeling the observed temperature curve (using NSCOOL) indicated that the source required ˜1.9 MeV per accreted nucleon of shallow heating in addition to the standard deep crustal heating to explain its thermal evolution. Alternatively, the decay could also be modelled without the presence of deep crustal heating, only having a shallow heat source (again ˜1.9 MeV per accreted nucleon was required). However, the XMM-Newton data statistically required an additional power-law component. This component contributed ˜30 per cent of the total unabsorbed flux in 0.5 - 10 keV energy range. The physical origin of this component is unknown. One possibility is that it arises from low-level accretion. The presence of this component in the spectrum complicates our cooling crust interpretation because it might indicate that the smooth luminosity and temperature decay curves we observed may not be due to crust cooling but due to some other process.

  16. Influence of amino acids, dietary protein, and physical activity on muscle mass development in humans

    DEFF Research Database (Denmark)

    Dideriksen, Kasper; Reitelseder, Søren; Holm, Lars

    2013-01-01

    intake. Ingestion of excess protein exerts an unwanted load to the body and therefore, it is important to find the least amount of protein that provides the maximal hypertrophic stimulus. Hence, research has focused on revealing the relationship between protein intake (dose) and its resulting stimulation...... response dependent on the characteristics of the protein ingested. The effect of protein intake on muscle protein accretion can further be stimulated by prior exercise training. In the ageing population, physical training may counteract the development of "anabolic resistance" and restore the beneficial...

  17. Sexual Dimorphism in Mass of the Hindlimb Muscles of the Piebald Odorous Frog (Odorrana schmackeri)

    Institute of Scientific and Technical Information of China (English)

    Lixia ZHANG; Yunyun ZHAO; Ling SHI Xiaohong CHEN; Youqiang LU; Liang QIAO

    2014-01-01

    Male-biased sexual dimorphism in hind limb muscles is widespread in anuran species where scramble competition is common among males. Such sexual difference is thought to result from sexual selection.In this view, we tested the differences in muscle mass between the sexes and between amplectant and non-amplectant males by quantifying the mass of four hindlimb muscles (triceps femoris, sartorius, gracilis and plantaris longus) of females and males ofOdorrana schmackeri. The results showed that females signiifcantly exceeded males for muscle triceps femoris, gracilis, plantaris longus and total mass when controlled for body size. There are no signiifcant differences between amplectant and non-amplectant males. It is probable that the maintenance of the amplectant position inO. schmackeri may depend on the strength of hindlimb muscles in females to support the pair.

  18. Cyclosporin-A does not affect skeletal muscle mass during disuse and recovery

    Directory of Open Access Journals (Sweden)

    M.S. Aoki

    2006-02-01

    Full Text Available Cyclosporin-A (CsA is an immunosuppressive drug that acts as an inhibitor of calcineurin, a calcium phosphatase that has been suggested to play a role in skeletal muscle hypertrophy. The aim of the present study was to determine the effect of CsA administration (25 mg kg-1 day-1 on skeletal muscle mass and phenotype during disuse and recovery. Male Wistar rats received vehicle (N = 8 or CsA (N = 8 during hind limb immobilization (N = 8 and recovery (N = 8. Muscle weight (dry/wet and cross-sectional area were evaluated to verify the effect of CsA treatment on muscle mass. Muscle phenotype was assessed by histochemistry of myosin ATPase. CsA administration during immobilization and recovery did not change muscle/body weight ratio in the soleus (SOL or plantaris (PL. Regarding muscle phenotype, we observed a consistent slow-to-fast shift in all experimental groups (immobilized only, receiving CsA only, and immobilized receiving CsA as compared to control in both SOL and PL (P < 0.05. During recovery, no difference was observed in SOL or PL fiber type composition between the experimental recovered group and recovered group receiving CsA compared to their respective controls. Considering the muscle/body weight ratio, CsA administration does not maximize muscle mass loss induced by immobilization. Our results also indicate that CsA fails to block skeletal muscle regrowth after disuse. The present data suggest that calcineurin inhibition by CsA modulates muscle phenotype rather than muscle mass.

  19. Effect of muscle mass on muscle mechanoreflex-mediated heart rate increase at the onset of dynamic exercise.

    Science.gov (United States)

    Vianna, Lauro C; Oliveira, Ricardo B; Ramos, Plínio S; Ricardo, Djalma R; Araújo, Claudio Gil S

    2010-02-01

    This study was conducted to determine whether the heart rate increase at the onset of passive dynamic exercise is related to the amount of skeletal muscle mass engaged in movement. Fifteen healthy male subjects, 18-30 years old, performed, from the 4th to the 8th second of a 12-s apnea, four different 4-s bouts of passive cycling assigned in a counterbalanced order, each one different from the others by the number of limbs engaged in the movement (i.e., 1 arm, 2 arms, 2 arms + 1 leg and 2 arms + 2 legs), while respiratory movements and limb muscle electromyography were recorded. A repeated-measures ANOVA showed that the RR interval at the end of 4-s passive cycling was reduced in all the four different bouts (P exercise to the end of 4 s of passive cycling) were directly related, in a non-linear trend, to the amount of muscle mass engaged in movement. These variations were more expressive when extremes were compared (110 +/- 16 vs. 184 +/- 24 ms, respectively, 1 limb vs. 4 limbs, P exercise. It was concluded that in healthy subjects, heart rate increase at the onset of passive cycling is directly related to the number of limbs and consequently the amount of muscle mass engaged, which is possibly related to a greater afferent input from stretch-sensitive muscle mechanoreceptors.

  20. Dietary Magnesium Is Positively Associated With Skeletal Muscle Power and Indices of Muscle Mass and May Attenuate the Association Between Circulating C-Reactive Protein and Muscle Mass in Women.

    Science.gov (United States)

    Welch, Ailsa A; Kelaiditi, Eirini; Jennings, Amy; Steves, Claire J; Spector, Tim D; MacGregor, Alexander

    2016-02-01

    Age-related loss of skeletal muscle mass and strength are risk factors for sarcopenia, osteoporosis, falls, fractures, frailty, and mortality. Dietary magnesium (Mg) could play a role in prevention of age-related loss of skeletal muscle mass, power, and strength directly through physiological mechanisms or indirectly through an impact on chronic low-grade inflammation, itself a risk factor for loss of skeletal muscle mass and strength. In a cross-sectional study of 2570 women aged 18 to 79 years, we examined associations between intakes of Mg, estimated using a food-frequency questionnaire (FFQ), dual-energy X-ray absorptiometry (DXA)-derived measures of muscle mass (fat-free mass as a percentage of body weight [FFM%], fat-free mass index [FFMI, kg/m(2)]), leg explosive power (LEP), and grip strength (n = 949 only). We also examined associations between circulating hs-CRP (C-reactive protein) and muscle mass and LEP, and explored the potential attenuation of these relationships by Mg. We compared our findings with those of age and protein intake. Endpoints were calculated by quintile of Mg and adjusted for relevant confounders. Significant positive associations were found between a higher Mg and indices of skeletal muscle mass and LEP, and also with hs-CRP, after adjustment for covariates. Contrasting extreme quintiles of Mg intake showed differences of 2.6% for FFM% (p trend protein, these positive associations were 7 times greater for FFM% and 2.5 times greater for LEP. We also found that higher hs-CRP was negatively associated with skeletal muscle mass and, in statistical modeling, that a higher dietary Mg attenuated this negative relationship by 6.5%, with greater attenuation in women older than 50 years. No association was found between Mg and grip strength. Our results suggest that dietary magnesium may aid conservation of age-related loss of skeletal muscle mass and power in women of all ages.

  1. The Impact of Low Muscle Mass Definition on the Prevalence of Sarcopenia in Older Australians

    Directory of Open Access Journals (Sweden)

    Solomon Yu

    2014-01-01

    Full Text Available Background. Sarcopenia is the presence of low muscle mass and low muscle function. The aim of this study was to establish cutoffs for low muscle mass using three published methods and to compare the prevalence of sarcopenia in older Australians. Methods. Gender specific cutoffs levels were identified for low muscle mass using three different methods. Low grip strength was determined using established cutoffs of <30 kg for men and <20 kg for women to estimate the prevalence of sarcopenia. Results. Gender specific cutoffs levels for low muscle mass identified were (a <6.89 kg/m2 for men and <4.32 kg/m2 for women, <2 standard deviation (SD of a young reference population; (b <7.36 kg/m2 for men and <5.81 kg/m2 for women from the lowest 20% percentile of the older group; and (c <−2.15 for men and <−1.42 for women from the lowest 20% of the residuals of linear regressions of appendicular skeletal mass, adjusted for fat mass and height. Prevalence of sarcopenia in older (65 years and older people by these three methods for men was 2.5%, 6.2%, and 6.4% and for women 0.3%, 9.3%, and 8.5%, respectively. Conclusions. Sarcopenia is common but consensus on the best method to confirm low muscle mass is required.

  2. Alterations in molecular muscle mass regulators after 8 days immobilizing Special Forces mission

    DEFF Research Database (Denmark)

    Jespersen, J G; Mikkelsen, U R; Nedergaard, A;

    2015-01-01

    In military operations, declined physical capacity can endanger the life of soldiers. During special support and reconnaissance (SSR) missions, Special Forces soldiers sustain 1-2 weeks full-body horizontal immobilization, which impairs muscle strength and performance. Adequate muscle mass and st...... and post 8 days immobilizing restricted prone position. After immobilization, total mammalian target of rapamycin protein was reduced by 42% (P ...

  3. Avian pectoral muscle size rapidly tracks body mass changes during flight, fasting and fuelling

    NARCIS (Netherlands)

    Lindstrom, A; Kvist, A; Piersma, T; Dekinga, A; Dietz, MW; Lindström, Åke

    2000-01-01

    We used ultrasonic imaging to monitor short-term changes in the pectoral muscle size of captive red knots Calidris canutus. Pectoral muscle thickness changed rapidly and consistently in parallel with body mass changes caused by flight, fasting;and fuelling. Four knots hew repeatedly for 10h periods

  4. Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity.

    Directory of Open Access Journals (Sweden)

    Tingqing Guo

    Full Text Available Myostatin (Mstn is a secreted growth factor expressed in skeletal muscle and adipose tissue that negatively regulates skeletal muscle mass. Mstn(-/- mice have a dramatic increase in muscle mass, reduction in fat mass, and resistance to diet-induced and genetic obesity. To determine how Mstn deletion causes reduced adiposity and resistance to obesity, we analyzed substrate utilization and insulin sensitivity in Mstn(-/- mice fed a standard chow. Despite reduced lipid oxidation in skeletal muscle, Mstn(-/- mice had no change in the rate of whole body lipid oxidation. In contrast, Mstn(-/- mice had increased glucose utilization and insulin sensitivity as measured by indirect calorimetry, glucose and insulin tolerance tests, and hyperinsulinemic-euglycemic clamp. To determine whether these metabolic effects were due primarily to the loss of myostatin signaling in muscle or adipose tissue, we compared two transgenic mouse lines carrying a dominant negative activin IIB receptor expressed specifically in adipocytes or skeletal muscle. We found that inhibition of myostatin signaling in adipose tissue had no effect on body composition, weight gain, or glucose and insulin tolerance in mice fed a standard diet or a high-fat diet. In contrast, inhibition of myostatin signaling in skeletal muscle, like Mstn deletion, resulted in increased lean mass, decreased fat mass, improved glucose metabolism on standard and high-fat diets, and resistance to diet-induced obesity. Our results demonstrate that Mstn(-/- mice have an increase in insulin sensitivity and glucose uptake, and that the reduction in adipose tissue mass in Mstn(-/- mice is an indirect result of metabolic changes in skeletal muscle. These data suggest that increasing muscle mass by administration of myostatin antagonists may be a promising therapeutic target for treating patients with obesity or diabetes.

  5. Is dynamometry able to infer the risk of muscle mass loss in patients with COPD?

    Directory of Open Access Journals (Sweden)

    Ramos D

    2015-07-01

    Full Text Available Dionei Ramos,1 Giovana Navarro Bertolini,1 Marceli Rocha Leite,1 Luiz Carlos Soares Carvalho Junior,1 Paula Roberta da Silva Pestana,1 Vanessa Ribeiro dos Santos,2 Ana Claudia de Souza Fortaleza,2 Fernanda Maria Machado Rodrigues,1 Ercy Mara Cipulo Ramos1 1Department of Physiotherapy, São Paulo State University, Presidente Prudente, Brazil; 2Department of Motricity Sciences, São Paulo State University, Rio Claro, Brazil Introduction: Sarcopenia is characterized by a progressive and generalized decrease of strength and muscle mass. Muscle mass loss is prevalent in patients with chronic obstructive pulmonary disease (COPD as a result of both the disease and aging. Some methods have been proposed to assess body composition (and therefore identify muscle mass loss in this population. Despite the high accuracy of some methods, they require sophisticated and costly equipment.Aim: The purpose of this study was to infer the occurrence of muscle mass loss measured by a sophisticated method (dual energy X-ray absorptiometry [DEXA] using a more simple and affordable equipment (dynamometer.Methods: Fifty-seven stable subjects with COPD were evaluated for anthropometric characteristics, lung function, functional exercise capacity, body composition, and peripheral muscle strength. A binary logistic regression model verified whether knee-extension strength (measured by dynamometry could infer muscle mass loss (from DEXA.Results: Patients with decreased knee-extension strength were 5.93 times more likely to have muscle mass loss, regardless of sex, disease stage, and functional exercise capacity (P=0.045.Conclusion: Knee-extension dynamometry was able to infer muscle mass loss in patients with COPD. Keywords: COPD, sarcopenia, peripheral muscle strength  

  6. Sarcopenia and liver transplant: The relevance of too little muscle mass.

    Science.gov (United States)

    Kallwitz, Eric R

    2015-10-21

    Loss of muscle mass and function is a common occurrence in both patients with decompensated cirrhosis and those undergoing liver transplantation. Sarcopenia is associated with morbidity and mortality before and after liver transplantation. The ability of skeletal muscle mass to recover after transplant is questionable, and long term adverse events associated with persistent sarcopenia have not been well studied. Limited data is available examining mechanisms by which decreased muscle mass might develop. It is not clear which interventions might reduce the prevalence of sarcopenia and associated health burdens. However, measures to either decrease portal hypertension or improve nutrition appear to have benefit. Research on sarcopenia in the liver transplant setting is hampered by differing methodology to quantify muscle mass and varied thresholds determining the presence of sarcopenia. One area highlighted in this review is the heterogeneity used when defining sarcopenia. The health consequences, clinical course and potential pathophysiologic mechanisms of sarcopenia in the setting of cirrhosis and liver transplantation are further discussed.

  7. Skeletal muscle mass and quality: evolution of modern measurement concepts in the context of sarcopenia.

    Science.gov (United States)

    Heymsfield, Steven B; Gonzalez, M Cristina; Lu, Jianhua; Jia, Guang; Zheng, Jolene

    2015-11-01

    The first reports of accurate skeletal muscle mass measurement in human subjects appeared at about the same time as introduction of the sarcopenia concept in the late 1980s. Since then these methods, computed tomography and MRI, have been used to gain insights into older (i.e. anthropometry and urinary markers) and more recently developed and refined methods (ultrasound, bioimpedance analysis and dual-energy X-ray absorptiometry) of quantifying regional and total body skeletal muscle mass. The objective of this review is to describe the evolution of these methods and their continued development in the context of sarcopenia evaluation and treatment. Advances in these technologies are described with a focus on additional quantifiable measures that relate to muscle composition and 'quality'. The integration of these collective evaluations with strength and physical performance indices is highlighted with linkages to evaluation of sarcopenia and the spectrum of related disorders such as sarcopenic obesity, cachexia and frailty. Our findings show that currently available methods and those in development are capable of non-invasively extending measures from solely 'mass' to quality evaluations that promise to close the gaps now recognised between skeletal muscle mass and muscle function, morbidity and mortality. As the largest tissue compartment in most adults, skeletal muscle mass and aspects of muscle composition can now be evaluated by a wide array of technologies that provide important new research and clinical opportunities aligned with the growing interest in the spectrum of conditions associated with sarcopenia.

  8. Accretion onto a Kiselev black hole

    Energy Technology Data Exchange (ETDEWEB)

    Jiao, Lei [Hebei University, College of Physical Science and Technology, Baoding (China); Yang, Rongjia [Hebei University, College of Physical Science and Technology, Baoding (China); Hebei University, Hebei Key Lab of Optic-Electronic Information and Materials, Baoding (China)

    2017-05-15

    We consider accretion onto a Kiselev black hole. We obtain the fundamental equations for accretion without the back-reaction. We determine the general analytic expressions for the critical points and the mass accretion rate and find the physical conditions the critical points should fulfill. The case of a polytropic gas are discussed in detail. It turns out that the quintessence parameter plays an important role in the accretion process. (orig.)

  9. Total body skeletal muscle mass: estimation by creatine (methyl-d3) dilution in humans.

    Science.gov (United States)

    Clark, Richard V; Walker, Ann C; O'Connor-Semmes, Robin L; Leonard, Michael S; Miller, Ram R; Stimpson, Stephen A; Turner, Scott M; Ravussin, Eric; Cefalu, William T; Hellerstein, Marc K; Evans, William J

    2014-06-15

    Current methods for clinical estimation of total body skeletal muscle mass have significant limitations. We tested the hypothesis that creatine (methyl-d3) dilution (D3-creatine) measured by enrichment of urine D3-creatinine reveals total body creatine pool size, providing an accurate estimate of total body skeletal muscle mass. Healthy subjects with different muscle masses [n = 35: 20 men (19-30 yr, 70-84 yr), 15 postmenopausal women (51-62 yr, 70-84 yr)] were housed for 5 days. Optimal tracer dose was explored with single oral doses of 30, 60, or 100 mg D3-creatine given on day 1. Serial plasma samples were collected for D3-creatine pharmacokinetics. All urine was collected through day 5. Creatine and creatinine (deuterated and unlabeled) were measured by liquid chromatography mass spectrometry. Total body creatine pool size and muscle mass were calculated from D3-creatinine enrichment in urine. Muscle mass was also measured by magnetic resonance imaging (MRI), dual-energy x-ray absorptiometry (DXA), and traditional 24-h urine creatinine. D3-creatine was rapidly absorbed and cleared with variable urinary excretion. Isotopic steady-state of D3-creatinine enrichment in the urine was achieved by 30.7 ± 11.2 h. Mean steady-state enrichment in urine provided muscle mass estimates that correlated well with MRI estimates for all subjects (r = 0.868, P creatine dose determined by urine D3-creatinine enrichment provides an estimate of total body muscle mass strongly correlated with estimates from serial MRI with less bias than total lean body mass assessment by DXA.

  10. Accretion discs trapped near corotation

    OpenAIRE

    D'Angelo, C.R.; Spruit, H.C.

    2012-01-01

    We show that discs accreting on to the magnetosphere of a rotating star can end up in a trapped state, in which the inner edge of the disc stays near the corotation radius, even at low and varying accretion rates. The accretion in these trapped states can be steady or cyclic; we explore these states over a wide range of parameter space. We find two distinct regions of instability: one related to the buildup and release of mass in the disc outside corotation, and the other to mass storage with...

  11. Alterations in molecular muscle mass regulators after 8 days immobilizing Special Forces mission

    DEFF Research Database (Denmark)

    Jespersen, J G; Mikkelsen, U R; Nedergaard, A

    2015-01-01

    In military operations, declined physical capacity can endanger the life of soldiers. During special support and reconnaissance (SSR) missions, Special Forces soldiers sustain 1-2 weeks full-body horizontal immobilization, which impairs muscle strength and performance. Adequate muscle mass...... and strength are necessary in combat or evacuation situations, which prompt for improved understanding of muscle mass modulation during SSR missions. To explore the molecular regulation of myofiber size during a simulated SSR operation, nine male Special Forces soldiers were biopsied in m. vastus lateralis pre...

  12. Tinetti mobility test is related to muscle mass and strength in non-institutionalized elderly people.

    Science.gov (United States)

    Curcio, Francesco; Basile, Claudia; Liguori, Ilaria; Della-Morte, David; Gargiulo, Gaetano; Galizia, Gianluigi; Testa, Gianluca; Langellotto, Assunta; Cacciatore, Francesco; Bonaduce, Domenico; Abete, Pasquale

    2016-12-01

    Elderly people are characterized by a high prevalence of falls and sarcopenia. However, the relationship among Tinetti mobility test (TMT) score, a powerful tool to detect elderly people at risk of falls, and sarcopenia is still not thoroughly investigated. Thus, to determine the relationship between TMT score and muscle mass and strength, 337 elderly participants (mean age 77.1 ± 6.9 years) admitted to comprehensive geriatric assessment were enrolled. TMT score, muscle mass by bioimpedentiometer, and muscle strength by grip strength were evaluated. Muscle mass progressively decreased as TMT score decreased (from 15.3 ± 3.7 to 8.8 ± 1.8 kg/m(2); p for trend Tinetti score decreased (from 34.7 ± 8.0 to 23.7 ± 8.7 kg; p for trend 0.001). Linear regression analysis demonstrated that TMT score is linearly related with muscle mass (y = 4.5x + 0.4, r = 0.61; p score and muscle mass (r = 0.48, p = 0.024) and strength (r = 0.39, p = 0.046). The present study indicates that TMT score is significantly related to muscle mass and strength in non-institutionalized elderly participants. This evidence suggests that TMT score, together with evaluation of muscle mass and strength, may identify sarcopenic elderly participants at high risk of falls.

  13. Impaired physical function, loss of muscle mass and assessment of biomechanical properties in critical ill patients

    DEFF Research Database (Denmark)

    Poulsen, Jesper Brøndum

    2012-01-01

    Intensive care unit (ICU) admission is associated with muscle weakness and ICU survivors report sustained limitation of physical capacity for years after discharge. Limited information is available on the underlying biomechanical properties responsible for this muscle function impairment....... A plausible contributor to the accentuated catabolic drive in ICU patients is a synergistic response to inflammation and inactivity leading to loss of muscle mass. As these entities are predominantly present in the early phase of ICU stay, interventions employed during this time frame may exhibit the greatest...... potential to counteract loss of muscle mass. Despite the obvious clinical significance of muscle atrophy for the functional impairment observed in ICU survivors, no preventive therapies have been identified as yet. The overall aim of the present dissertation is to characterize aspects of physical function...

  14. New insights into AGNs with low-mass black holes and high accretion rates:the case of narrow-line Seyfert 1 galaxies

    Institute of Scientific and Technical Information of China (English)

    KOMOSSA; S

    2010-01-01

    Narrow-line Seyfert 1(NLS1) galaxies are believed to harbor low-mass black holes accreting at high rates,and they are therefore important targets when studying the nature of black hole growth,galaxy evolution,and accretion physics.We have rigorously studied the physical properties of a sample of NLS1 galaxies.We briefly review previous findings and present new results,including:(1) The locus of NLS1 galaxies on the MBH-σ plane,which we find to follow the relation of non-active galaxies after removing objects obviously dominated by outflows.(2) The presence of "blue outliers" which hint at extreme outflows as they would be predicted from merger models.(3) More subtle evidence for winds and outflows across the whole NLS1 population.(4) New correlations and trends which link black hole mass,Eddington ratio and physical parameters of the emission-line region.A new element is added to the eigenvector 1 space based on a principal component analysis,which aims at identifying the main drivers of AGN correlation properties.

  15. Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients

    Directory of Open Access Journals (Sweden)

    Ferrari R

    2015-08-01

    Full Text Available Renata Ferrari,1 Laura MO Caram,1 Marcia M Faganello,2 Fernanda F Sanchez,3 Suzana E Tanni,1 Irma Godoy1 1Botucatu Medical School, Department of Internal Medicine, Pneumology Area, Botucatu, São Paulo, 2Paulista State University, Department of Physiotherapy and Occupational Therapy, Marilia, São Paulo, 3Federal University of Amazonas, Department of Physiotherapy, Manaus, Amazonas, Brazil Abstract: The aim of this study was to investigate the association between systemic inflammatory mediators and peripheral muscle mass and strength in COPD patients. Fifty-five patients (69% male; age: 64±9 years with mild/very severe COPD (defined as forced expiratory volume in the first second [FEV1] =54%±23% were evaluated. We evaluated serum concentrations of IL-8, CRP, and TNF-α. Peripheral muscle mass was evaluated by computerized tomography (CT; midthigh cross-sectional muscle area (MTCSA and midarm cross-sectional muscle area (MACSA were obtained. Quadriceps, triceps, and biceps strength were assessed through the determination of the one-repetition maximum. The multiple regression results, adjusted for age, sex, and FEV1%, showed positive significant association between MTCSA and leg extension (0.35 [0.16, 0.55]; P=0.001, between MACSA and triceps pulley (0.45 [0.31, 0.58]; P=0.001, and between MACSA and biceps curl (0.34 [0.22, 0.47]; P=0.001. Plasma TNF-α was negatively associated with leg extension (-3.09 [-5.99, -0.18]; P=0.04 and triceps pulley (-1.31 [-2.35, -0.28]; P=0.01, while plasma CRP presented negative association with biceps curl (-0.06 [-0.11, -0.01]; P=0.02. Our results showed negative association between peripheral muscle mass (evaluated by CT and muscle strength and that systemic inflammation has a negative influence in the strength of specific groups of muscles in individuals with stable COPD. This is the first study showing association between systemic inflammatory markers and strength in upper limb muscles. Keywords

  16. Discovery of a Three-Layered Atmospheric Structure in Accretion Disks around Stellar-Mass Black Holes

    Science.gov (United States)

    Zhang, S. N.; Zhang, Xiaoling; Sun, Xuejun; Yao, Yangsen; Cui, Wei; Chen, Wan; Wu, Xuebing; Xu, Haiguang

    1999-01-01

    We have carried out systematic modeling of the X-ray spectra of the Galactic superluminal jet sources GRS 1915+105 and GRO J1655-40, using our newly developed spectral fitting methods. Our results reveal, for the first time, a three-layered structure of the atmosphere in the inner region of the accretion disks. Above the conanonly known, cold and optically thick disk of a blackbody temperature 0.2-0.5 keV, there is a layer of warm gas with a temperature of 1.0-1.5 keV and an optical depth of around 10. Compton scattering of the underlying disk blackbody photons produces the soft X-ray component we comonly observe. Under certain conditions, there is also a much hotter, optically thin corona above the warm layer, characterized by a temperature of 100 keV or higher and an optical depth of unity or less. The corona produces the hard X-ray component typically seen in these sources. We emphasize that the existence of the warm layer seem to be independent of the presence of the hot corona and, therefore, it is not due to irradiation of the disk by hard X-rays from the corona. Our results suggest a striking structural similarity between the accretion disks and the solar atmosphere, which may provide a new stimulus to study the common underlying physical processes operating in these vastly different systems. We also report the first unambiguous detection of an emission line around 6.4 keV in GRO J1655-40, which may allow further constraining of the accretion disk structure. We acknowledge NASA GSFC and MFC for partial financial support. (copyright) 1999: American Astronomical Society. All rights reverved.

  17. Skeletal muscle mass and exercise performance in stable ambulatory patients with heart failure.

    Science.gov (United States)

    Lang, C C; Chomsky, D B; Rayos, G; Yeoh, T K; Wilson, J R

    1997-01-01

    The purpose of this study was to determine whether skeletal muscle atrophy limits the maximal exercise capacity of stable ambulatory patients with heart failure. Body composition and maximal exercise capacity were measured in 100 stable ambulatory patients with heart failure. Body composition was assessed by using dual-energy X-ray absorption. Peak exercise oxygen consumption (VO2peak) and the anaerobic threshold were measured by using a Naughton treadmill protocol and a Medical Graphics CardioO2 System. VO2peak averaged 13.4 +/- 3.3 ml.min-1.kg-1 or 43 +/- 12% of normal. Lean body mass averaged 52.9 +/- 10.5 kg and leg lean mass 16.5 +/- 3.6 kg. Leg lean mass correlated linearly with VO2peak (r = 0.68, P < 0.01), suggesting that exercise performance is influences by skeletal muscle mass. However, lean body mass was comparable to levels noted in 1,584 normal control subjects, suggesting no decrease in muscle mass. Leg muscle mass was comparable to levels noted in 34 normal control subjects, further supporting this conclusion. These findings suggest that exercise intolerance in stable ambulatory patients with heart failure is not due to skeletal muscle atrophy.

  18. Muscle mass loss and intermuscular lipid accumulation were associated with insulin resistance in patients receiving hemodialysis

    Institute of Scientific and Technical Information of China (English)

    WANG Hui-ling; DING Ting-ting; LU Shi; XU Ye; TIAN Jun; HU Wei-feng; ZHANG Jin-yuan

    2013-01-01

    Background An accelerated muscle wasting was the pivotal factor for protein-energy wasting in end stage renal disease.However,very few researches have examined the skeletal muscle quantity and quality in clinical patients.This study investigated the muscle morphologic changes by magnetic resonance imaging (MRI) and analyzed the related factors in hemodialysis patients.Methods Fifty-eight patients receiving maintenance hemodialysis (HD) were investigated and 28 healthy adults with gender and age matched were used as controls (Control).Anthropometry,cytokine factors,and laboratory data were measured.The muscle and intermuscular adipose tissues (IMAT) were analyzed via a Thigh MRI.The bicep samples were observed after HE staining.Homeostatic model assessment of insulin resistance (HOMA-IR) was measured and their association with muscle wasting was analyzed.Results HD patients tended to have a lower protein diet,anthropometry data,and serum albumin,but the C reactive protein and interleukin-6 increased significantly.The MRI showed that HD patients had less muscle mass and a lower muscle/total ratio,but the fat/muscle and IMAT was higher when compared to the Control group.The muscle fiber showed atrophy and fat accumulation in the biceps samples come from the HD patients.Moreover,we found that the HD patients presented with a high level of plasma fasting insulin and increased HOMA-IR which negatively correlated with the muscle/total ratio,but positively with the fat/muscle ratio.Conclusions Muscle wasting presented early before an obvious malnutrition condition emerged in HD patients.The main morphological change was muscle atrophy along with intermuscular lipid accumulation.Insulin resistance was associated with muscle wasting in dialysis patients.

  19. Intermittent stretch training of rabbit plantarflexor muscles increases soleus mass and serial sarcomere number.

    Science.gov (United States)

    De Jaeger, Dominique; Joumaa, Venus; Herzog, Walter

    2015-06-15

    In humans, enhanced joint range of motion is observed after static stretch training and results either from an increased stretch tolerance or from a change in the biomechanical properties of the muscle-tendon unit. We investigated the effects of an intermittent stretch training on muscle biomechanical and structural variables. The left plantarflexors muscles of seven anesthetized New Zealand (NZ) White rabbits were passively and statically stretched three times a week for 4 wk, while the corresponding right muscles were used as nonstretched contralateral controls. Before and after the stretching protocol, passive torque produced by the left plantarflexor muscles as a function of the ankle angle was measured. The left and right plantarflexor muscles were harvested from dead rabbits and used to quantify possible changes in muscle structure. Significant mass and serial sarcomere number increases were observed in the stretched soleus but not in the plantaris or medial gastrocnemius. This difference in adaptation between the plantarflexors is thought to be the result of their different fiber type composition and pennation angles. Neither titin isoform nor collagen amount was modified in the stretched compared with the control soleus muscle. Passive torque developed during ankle dorsiflexion was not modified after the stretch training on average, but was decreased in five of the seven experimental rabbits. Thus, an intermittent stretching program similar to those used in humans can produce a change in the muscle structure of NZ White rabbits, which was associated in some rabbits with a change in the biomechanical properties of the muscle-tendon unit.

  20. Temperaments of young stars: Rapid mass-accretion rate changes in T Tauri and Herbig Ae stars

    CERN Document Server

    Costigan, Gráinne; Scholz, Aleks; Ray, Tom; Testi, Leonardo

    2014-01-01

    Variability in emission lines is a characteristic feature in young stars and can be used as a tool to study the physics of the accretion process. Here we present a study of H{\\alpha} variability in 15 T Tauri and Herbig Ae stars (K7-B2) over a wide range of time windows, from minutes, to hours, to days, and years. We assess the variability using linewidth measurements and the time series of line profiles. All objects show gradual, slow profile changes on time-scales of days. In addition, in three cases there is evidence for rapid variations in H{\\alpha} with typical time-scales of 10 min, which occurs in 10% of the total covered observing time. The mean accretion-rate changes, inferred from the line fluxes,are 0.01-0.07 dex for time-scales of < 1 hour, 0.04-0.4 dex for time-scales of days, and 0.13-0.52 dex for time-scales of years. In Costigan et al. 2012 we derived an upper limit finding that the intermediate (days) variability dominated over longer (years) variability. Here our new results, based on muc...

  1. Temporal variability of carbon and nutrient burial, sediment accretion, and mass accumulation over the past century in a carbonate platform mangrove forest of the Florida Everglades.

    Science.gov (United States)

    Breithaupt, Josh L.; Smoak, Joseph M.; Smith, Thomas J.; Sanders, Christian J.

    2014-01-01

    The objective of this research was to measure temporal variability in accretion and mass sedimentation rates (including organic carbon (OC), total nitrogen (TN), and total phosphorous (TP)) from the past century in a mangrove forest on the Shark River in Everglades National Park, USA. The 210Pb Constant Rate of Supply model was applied to six soil cores to calculate annual rates over the most recent 10, 50, and 100 year time spans. Our results show that rates integrated over longer timeframes are lower than those for shorter, recent periods of observation. Additionally, the substantial spatial variability between cores over the 10 year period is diminished over the 100 year record, raising two important implications. First, a multiple-decade assessment of soil accretion and OC burial provides a more conservative estimate and is likely to be most relevant for forecasting these rates relative to long-term processes of sea level rise and climate change mitigation. Second, a small number of sampling locations are better able to account for spatial variability over the longer periods than for the shorter periods. The site average 100 year OC burial rate, 123 ± 19 (standard deviation) g m-2yr-1, is low compared with global mangrove values. High TN and TP burial rates in recent decades may lead to increased soil carbon remineralization, contributing to the low carbon burial rates. Finally, the strong correlation between OC burial and accretion across this site signals the substantial contribution of OC to soil building in addition to the ecosystem service of CO2 sequestration.

  2. Total-body skeletal muscle mass determination by D3-creatine dilution in mice

    Directory of Open Access Journals (Sweden)

    Yue-bing WANG

    2017-08-01

    Full Text Available Objective To investigate the potentiality of D3-creatine dilution method to be used in detection of skeletal muscle mass, so as to provide a new method for skeletal muscle mass detection in mice. Methods Four weeks, 10 weeks and 13 months old male C57BL/6 mice (10 each were used in the present study. All mice were fed with a single dose of D3-creatine (2mg/kg after testing body composition by EchoMRITM. Urine was collected at 24h, 48h and 72h after creatine administration, and analyzed by liquid chromatography-tandem mass spectrometry mass spectrometry (LC-MS/MS that was used to determine the creatine pool size. The relationship between creatine pool size and the skeletal muscle mass determined by EchoMRITM was analyzed. Results Both lean body mass and total creatine pool size were aged mice > adult mice > juvenile mice. There was a significant correlation (r=0.687, P=0.000 between the lean body mass measured by EchoMRITM and the total creatine pool size calculated by D3-creatine dilution method. Conclusion The D3-creatine dilution method may be used to determine the skeletal muscle mass of mice. DOI: 10.11855/j.issn.0577-7402.2017.07.10

  3. Age-related decline in muscle mass and muscle function in Flemish Caucasians: a 10-year follow-up.

    Science.gov (United States)

    Charlier, Ruben; Knaeps, Sara; Mertens, Evelien; Van Roie, Evelien; Delecluse, Christophe; Lefevre, Johan; Thomis, Martine

    2016-04-01

    Aging is a complex process that is accompanied with changes in both muscle mass and muscle function (strength and performance). Therefore, the current longitudinal study aimed to provide a better insight in 10-year aging-related changes in whole-body muscle mass and strength performance of the leg extensors during the adult life span. Data were gathered within the framework of the first- (2002-2004: baseline) and third-generation Flemish Policy Research Center Sport (2012-2014: follow-up). Results are based on muscle characteristics data of 591 Flemish Caucasian adults (19-73 years, 381 men). Skeletal muscle mass (SMM) was determined with bioelectrical impedance analysis. Biodex Medical System 3® dynamometer was used to measure isometric (PTstatic120°) and isokinetic (PTdynamic60° and PTdynamic240°) strength, ballistic movement speed (S 20 %), and muscular endurance (work) of the knee extensors. Overall strength performance was higher at both evaluation moments in men compared to women (p < 0.01). But only S 20 % declined significantly faster in men compared to women (p < 0.01). Age and baseline strength performance were negatively related with the change in strength performance, even when corrected for SMM, protein intake, and energy expenditure during sports (E sport). In conclusion, strength performance was not associated with E sport in this study, but protein intake was associated with isometric strength in men, and with ballistic and isokinetic strength in women. Changes in S 20 % were significantly greater in men compared to women. Baseline values of strength performance and age were associated with changes in strength performance parameters, even after correction for SMM, protein intake, and E sport.

  4. [Influence of preliminary information about mass on anticipatory muscle activity during catching of falling object].

    Science.gov (United States)

    Kazennikov, O V; Lipshits, M I

    2010-01-01

    Heavy or light object fell into the cup held between thumb and index fingers of sitting subject. The anticipatory muscle activity and the grip force applied to cup depended on the mass of object while the temporal parameters (time of beginning of muscle activity, duration of the activity, the time of grip force maximum) were constant. The preliminary verbal information about mass of the falling object was enough for predictive force programming. Without such information, i.e. during fall the object of unknown mass the anticipatory activity was planned in expectation of heavy weight.

  5. Peak muscle mass in young men and sarcopenia in the ageing male

    DEFF Research Database (Denmark)

    Nielsen, Morten Frost Munk; Nielsen, T L; Brixen, K

    2015-01-01

    The prevalence of sarcopenia increases with age. The diagnosis of sarcopenia relies in part on normative data on muscle mass, but these data are lacking. This study provides population-based reference data on muscle mass in young men, and these results may be used clinically for the diagnosis...... of sarcopenia in men. INTRODUCTION: The ageing population increases the prevalence of sarcopenia. Estimation of normative data on muscle mass in young men during the peak of anabolic hormones is necessary for the diagnosis of sarcopenia in ageing males. The purposes of this study were to provide population......-based reference data on lean body mass (LBM) in young men during the time of peak levels of GH/IGF-1 and testosterone and further to apply the reference data on a population-based sample of men aged 60-74 years to estimate the prevalence of sarcopenia. METHODS: This is a cross-sectional, population-based single...

  6. He-Accreting WDs: accretion regimes and final outcomes

    CERN Document Server

    Piersanti, L; Yungelson, L R

    2014-01-01

    The behaviour of carbon-oxygen white dwarfs (WDs) subject to direct helium accretion is extensively studied. We aim to analyze the thermal response of the accreting WD to mass deposition at different time scales. The analysis has been performed for initial WDs masses and accretion rates in the range (0.60 - 1.02) Msun and 1.e-9 - 1.e-5 Msun/yr, respectively. Thermal regimes in the parameters space M_{WD} - dot{M}_{He}, leading to formation of red-giant-like structure, steady burning of He, mild, strong and dynamical flashes have been identified and the transition between those regimes has been studied in detail. In particular, the physical properties of WDs experiencing the He-flash accretion regime have been investigated in order to determine the mass retention efficiency as a function of the accretor total mass and accretion rate. We also discuss to what extent the building-up of a He-rich layer via H-burning could be described according to the behaviour of models accreting He-rich matter directly. Polynomi...

  7. Time-of-flight mass measurements of neutron-rich chromium isotopes up to N = 40 and implications for the accreted neutron star crust

    CERN Document Server

    Meisel, Z; Ahn, S; Bazin, D; Brown, B A; Browne, J; Carpino, J F; Chung, H; Cyburt, R H; Estradé, A; Famiano, M; Gade, A; Langer, C; Matoš, M; Mittig, W; Montes, F; Morrissey, D J; Pereira, J; Schatz, H; Schatz, J; Scott, M; Shapira, D; Sieja, K; Smith, K; Stevens, J; Tan, W; Tarasov, O; Towers, S; Wimmer, K; Winkelbauer, J R; Yurkon, J; Zegers, R G T

    2016-01-01

    We present the mass excesses of 59-64Cr, obtained from recent time-of-flight nuclear mass measurements at the National Superconducting Cyclotron Laboratory at Michigan State University. The mass of 64Cr is determined for the first time, with an atomic mass excess of -33.48(44) MeV. We find a significantly different two-neutron separation energy S2n trend for neutron-rich isotopes of chromium, removing the previously observed enhancement in binding at N=38. Additionally, we extend the S2n trend for chromium to N=40, revealing behavior consistent with the previously identified island of inversion in this region. We compare our results to state-of-the-art shell-model calculations performed with a modified Lenzi-Nowacki-Poves-Sieja interaction in the fp shell, including the g9/2 and d5/2 orbits for the neutron valence space. We employ our result for the mass of 64Cr in accreted neutron star crust network calculations and find a reduction in the strength and depth of electron-capture heating from the A=64 isobaric...

  8. DISCOVERY AND OBSERVATIONS OF ASASSN-13db, AN EX LUPI-TYPE ACCRETION EVENT ON A LOW-MASS T TAURI STAR

    Energy Technology Data Exchange (ETDEWEB)

    Holoien, Thomas W.-S.; Stanek, K. Z.; Kochanek, C. S.; Shappee, B. J.; Croxall, K.; Wagner, R. M.; Basu, U.; Beacom, J. F.; Jencson, J. [Department of Astronomy, The Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Prieto, Jose L.; Zhu, Z. [Department of Astrophysical Sciences, Princeton University, 4 Ivy Lane, Peyton Hall, Princeton, NJ 08544 (United States); Sicilia-Aguilar, A. [Departamento de Física Teórica, Facultad de Ciencias, Universidad Autónoma de Madrid, E-28049 Cantoblanco, Madrid (Spain); Grupe, D. [Department of Astronomy and Astrophysics, Pennsylvania State University, 525 Davey Lab, University Park, PA 16802 (United States); Adams, J. J.; Simon, J. D. [Observatories of the Carnegie Institution for Science, 813 Santa Barbara St., Pasadena, CA 91101 (United States); Morrell, N. [Carnegie Observatories, Las Campanas Observatory, Colina El Pino, Casilla 601 (Chile); McGraw, S. M. [Department of Physics and Astronomy, Ohio University, 251B Clippinger Labs, Athens, OH 45701 (United States); Bersier, D. [Astrophysics Research Institute, Liverpool John Moores University, 146 Brownlow Hill, Liverpool L3 5RF (United Kingdom); Brimacombe, J. [Coral Towers Observatory, Cairns, Queensland 4870 (Australia); Pojmanski, G., E-mail: tholoien@astronomy.ohio-state.edu [Warsaw University Astronomical Observatory, Al. Ujazdowskie 4, 00-478 Warsaw (Poland); and others

    2014-04-20

    We discuss ASASSN-13db, an EX Lupi-type ({sup E}Xor{sup )} accretion event on the young stellar object (YSO) SDSS J051011.01–032826.2 (hereafter SDSSJ0510) discovered by the All-Sky Automated Survey for SuperNovae (ASAS-SN). Using archival photometric data of SDSSJ0510 we construct a pre-outburst spectral energy distribution and find that it is consistent with a low-mass class II YSO near the Orion star forming region (d ∼ 420 pc). We present follow-up photometric and spectroscopic observations of the source after the ΔV ∼ –5.4 mag outburst that began in 2013 September and ended in early 2014. These data indicate an increase in temperature and luminosity consistent with an accretion rate of ∼10{sup –7} M {sub ☉} yr{sup –1}, three or more orders of magnitude greater than in quiescence. Spectroscopic observations show a forest of narrow emission lines dominated by neutral metallic lines from Fe I and some low-ionization lines. The properties of ASASSN-13db are similar to those of the EXor prototype EX Lupi during its strongest observed outburst in late 2008.

  9. Daily, multiwavelength Swift monitoring of the neutron star low-mass X-ray binary Cen X-4: evidence for accretion and reprocessing during quiescence

    CERN Document Server

    Bernardini, F; Brown, E F; Degenaar, C D'Angelo N; Miller, J M; Reynolds, M; Wijnands, R

    2013-01-01

    The physics of accretion during quiescence in low mass X-ray binaries (LMXBs) is poorly understood, yet there are signs that accretion must be happening. Several LMXBs show variability during quiescence, particularly striking is the case of the nearby neutron star Cen X-4. With the goal of unveiling the real nature of its quiescent variability we conducted the first long-term, multiwavelength simultaneous monitoring of Cen X-4, thanks to 60 observations performed by Swift on a daily basis. During those observations, Cen X-4 is highly variable in all energy bands on timescales from days to months, with the strongest quiescent short-term variability detected in the X-ray band, a factor of 22 drop in only 4 days. The X-ray and the UV and optical emission are correlated on timescales down to less than 110 s. The shape of the correlation is a power law with index 0.2-0.6. The X-ray spectrum is well fitted by a hydrogen NS atmosphere (kT=59-80 eV) and a power law (spectral index 1.4-2.0). The spectral shape remains...

  10. Physical Environment of Accreting Neutron Stars

    Directory of Open Access Journals (Sweden)

    J. Wang

    2016-01-01

    Full Text Available Neutron stars (NSs powered by accretion, which are known as accretion-powered NSs, always are located in binary systems and manifest themselves as X-ray sources. Physical processes taking place during the accretion of material from their companions form a challenging and appealing topic, because of the strong magnetic field of NSs. In this paper, we review the physical process of accretion onto magnetized NS in X-ray binary systems. We, firstly, give an introduction to accretion-powered NSs and review the accretion mechanism in X-ray binaries. This review is mostly focused on accretion-induced evolution of NSs, which includes scenario of NSs both in high-mass binaries and in low-mass systems.

  11. Migration of accreting giant planets

    Science.gov (United States)

    Crida, A.; Bitsch, B.; Raibaldi, A.

    2016-12-01

    We present the results of 2D hydro simulations of giant planets in proto-planetary discs, which accrete gas at a more or less high rate. First, starting from a solid core of 20 Earth masses, we show that as soon as the runaway accretion of gas turns on, the planet is saved from type I migration : the gap opening mass is reached before the planet is lost into its host star. Furthermore, gas accretion helps opening the gap in low mass discs. Consequently, if the accretion rate is limited to the disc supply, then the planet is already inside a gap and in type II migration. We further show that the type II migration of a Jupiter mass planet actually depends on its accretion rate. Only when the accretion is high do we retrieve the classical picture where no gas crosses the gap and the planet follows the disc spreading. These results impact our understanding of planet migration and planet population synthesis models. The e-poster presenting these results in French can be found here: L'e-poster présentant ces résultats en français est disponible à cette adresse: http://sf2a.eu/semaine-sf2a/2016/posterpdfs/156_179_49.pdf.

  12. Locomotion and muscle mass measures in a murine model of collagen-induced arthritis

    Directory of Open Access Journals (Sweden)

    Hartog Anita

    2009-06-01

    Full Text Available Abstract Background Rheumatoid arthritis (RA is characterized by chronic poly-arthritis, synovial hyperplasia, erosive synovitis, progressive cartilage and bone destruction accompanied by a loss of body cell mass. This loss of cell mass, known as rheumatoid cachexia, predominates in the skeletal muscle and can in part be explained by a decreased physical activity. The murine collagen induced arthritis (CIA model has been proven to be a useful model in RA research since it shares many immunological and pathological features with human RA. The present study explored the interactions between arthritis development, locomotion and muscle mass in the CIA model. Methods CIA was induced in male DBA/1 mice. Locomotion was registered at different time points by a camera and evaluated by a computerized tracing system. Arthritis severity was detected by the traditionally used semi-quantitative clinical scores. The muscle mass of the hind-legs was detected at the end of the study by weighing. A methotrexate (MTX intervention group was included to study the applicability of the locomotion and muscle mass for testing effectiveness of interventions in more detail. Results There is a strong correlation between clinical arthritis and locomotion. The correlations between muscle mass and locomotion or clinical arthritis were less pronounced. MTX intervention resulted in an improvement of disease severity accompanied by an increase in locomotion and muscle mass. Conclusion The present data demonstrate that registration of locomotion followed by a computerized evaluation of the movements is a simple non invasive quantitative method to define disease severity and evaluate effectiveness of therapeutic agents in the CIA model.

  13. Creatinine excretion rate, a marker of muscle mass, is related to clinical outcome in patients with chronic systolic heart failure

    NARCIS (Netherlands)

    ter Maaten, Jozine M.; Damman, Kevin; Hillege, Hans L.; Bakker, Stephan J.; Anker, Stefan D.; Navis, Gerjan; Voors, Adriaan A.

    2014-01-01

    Aims In chronic heart failure (CHF), low body mass as a reflection of low muscle mass has been associated with poor outcome. Urinary creatinine excretion rate (CER) is an established marker of muscle mass, but has not been investigated in CHF. This study aims to evaluate urinary CER as a marker of m

  14. Primary establishment of human uterine muscle proteomic profiling by two-dimensional electrophoresis and mass spectrometry

    Institute of Scientific and Technical Information of China (English)

    Lin Hai-yuan; Lang Jing-he; Liu Zhu-feng; Zhu Lan; Leng Jin-hua; Sun Da-wei; Wang Xiao-rong

    2008-01-01

    Objective:To establish the protein profiling of human uterine muscle by two-dimensional electrophoresis.Methods:Five patients who underwent trans-abdominal hysterectomy due to cervical carcinoma in situ were in-cluded in this study.Postoperative uterine muscles were normal histologically.The total protein extracts from uter-ine muscle were separated using two-dimensional electrophoresis(2DE).Protein spots were stained by silver and de-tected by image analysis software.Matrix-assisted laser desorption/ionization time of flight mass spectrometry(MALDI-TOF-MS)and peptide mass fingerprint(PMF)were used to identify the selected protein spots.Results:Well-resolved,reproducible 2DE maps of human uterine muscle were obtained.Average protein spots were 468±52 and matching rate was 82.76%.Five protein spots were successfully identified by mass spectrome-try.Conclusions:2DE coupled with MALDI-TOF-MS and PMF is a useful approach for establishing human uterine muscle proteomic profiling.This data will be useful for establishing human uterine muscle proteome database.

  15. Influence of step-height and body mass on gastrocnemius muscle fascicle behavior during stair ascent.

    Science.gov (United States)

    Spanjaard, M; Reeves, N D; van Dieën, J H; Baltzopoulos, V; Maganaris, C N

    2008-01-01

    To better understand the role of the ankle plantar flexor muscles in stair negotiation, we examined the effects of manipulation of kinematic and kinetic constraints on the behavior of the gastrocnemius medialis (GM) muscle during stair ascent. Ten subjects ascended a four-step staircase at four different step-heights (changing the kinematic constraints): standard (17 cm), 50% decreased, 50% increased and 75% increased. At the standard height, subjects also ascended the stairs wearing a weighted jacket, adding 20% of their body mass (changing the kinetic constraints). During stair ascent, kinematics and kinetics of the lower legs were determined using motion capture and ground reaction force measurements. The GM muscle fascicle length was measured during the task with ultrasonography. The amount of GM muscle fascicle shortening increased with step-height, coinciding with an increase in ankle joint moment. The increase in body mass resulted in an increased ankle joint moment, but the amount of GM muscle fascicle shortening during the lift-off phase did not increase, instead, the fascicles were shorter over the whole stride cycle. Increasing demands of stair ascent, by increasing step-height or body mass, requires higher joint moments. The increased ankle joint moment with increasing demands is, at least in part, produced by the increase in GM muscle fascicle shortening.

  16. Effect of muscle mass on toxicity and survival in patients with colon cancer undergoing adjuvant chemotherapy.

    Science.gov (United States)

    Jung, Hee-Won; Kim, Jin Won; Kim, Ji-Yeon; Kim, Sun-Wook; Yang, Hyun Kyung; Lee, Joon Woo; Lee, Keun-Wook; Kim, Duck-Woo; Kang, Sung-Bum; Kim, Kwang-Il; Kim, Cheol-Ho; Kim, Jee Hyun

    2015-03-01

    The purpose of this study was to elucidate the effect of decreased muscle mass on the toxicity and survival of patients with colon cancer treated with adjuvant chemotherapy after surgery. We reviewed the data of 229 consecutive patients with stage III colon cancer who received adjuvant oxaliplatin, 5-fluorouracil, and leucovorin chemotherapy at a single center between 2003 and 2010. Baseline muscle mass was assessed by measuring the cross-sectional area of the psoas muscle at the level of the fourth lumbar vertebra on computed tomography images. Effects of muscle mass on toxicity of chemotherapy and survival were assessed. The median age of the 229 patients was 61 years (range, 28-80) and 134 (58.5 %) were men. The mean psoas muscle mass index (PI, psoas muscle area divided by height(2) [mm(2)/m(2)]) was 548.3. A 1 SD decrement in the PI was associated with an increase in all grade 3-4 toxicities in univariate (OR = 1.69, 95 % CI = 1.18-2.27) and multivariate (OR = 1.56, 95 % CI = 1.05-2.38) analyses. In univariate analysis, the PI was not associated with overall survival. However, multivariate analysis showed that a 1 SD decrement in the PI increased the hazard of overall mortality by 85 % (HR = 1.85, 95 % CI = 1.10-3.13). This effect of the PI on mortality was maintained in subgroup analyses, especially in older and obese patients. Decreased muscle mass was associated with increased risk of grade 3-4 toxicity and poor prognosis in patients with stage III colon cancer.

  17. Relative Skeletal Muscle Mass Is Associated with Development of Metabolic Syndrome

    Directory of Open Access Journals (Sweden)

    Byung Sam Park

    2013-12-01

    Full Text Available BackgroundVisceral adiposity is related to insulin resistance. Skeletal muscle plays a central role in insulin-mediated glucose disposal; however, little is known about the association between muscle mass and metabolic syndrome (MS. This study is to clarify the clinical role of skeletal muscle mass in development of MS.MethodsA total of 1,042 subjects were enrolled. Subjects with prior MS and chronic diseases were excluded. After 24 months, development of MS was assessed using NCEP-ATP III criteria. Skeletal muscle mass (SMM; kg, body fat mass (BFM; kg, and visceral fat area (VFA; cm2 were obtained from bioelectrical analysis. Then, the following values were calculated as follows: percent of SMM (SMM%; %: SMM (kg/weight (kg, skeletal muscle index (SMI; kg/m2: SMM (kg/height (m2, skeletal muscle to body fat ratio (MFR: SMM (kg/BFM (kg, and skeletal muscle to visceral fat ratio (SVR; kg/cm2: SMM (kg/VFA (cm2.ResultsAmong 838 subjects, 88 (10.5% were newly diagnosed with MS. Development of MS increased according to increasing quintiles of BMI, SMM, VFA, and SMI, but was negatively associated with SMM%, MFR, and SVR. VFA was positively associated with high waist circumference (WC, high blood pressure (BP, dysglycemia, and high triglyceride (TG. In contrast, MFR was negatively associated with high WC, high BP, dysglycemia, and high TG. SVR was negatively associated with all components of MS.ConclusionRelative SMM ratio to body composition, rather than absolute mass, may play a critical role in development of MS and could be used as a strong predictor.

  18. Self-gravitating accretion discs

    OpenAIRE

    Lodato, G.

    2008-01-01

    I review recent progresses in the dynamics and the evolution of self-gravitating accretion discs. Accretion discs are a fundamental component of several astrophysical systems on very diverse scales, and can be found around supermassive black holes in Active Galactic Nuclei (AGN), and also in our Galaxy around stellar mass compact objects and around young stars. Notwithstanding the specific differences arising from such diversity in physical extent, all these systems share a common feature whe...

  19. Evaluating Muscle Mass by Using Markers of Kidney Function: Development of the Sarcopenia Index.

    Science.gov (United States)

    Kashani, Kianoush B; Frazee, Erin N; Kukrálová, Lucie; Sarvottam, Kumar; Herasevich, Vitaly; Young, Phillip M; Kashyap, Rahul; Lieske, John C

    2017-01-01

    Sarcopenia is associated with a poor prognosis in the ICU. The purpose of this study was to describe a simple sarcopenia index using routinely available renal biomarkers and evaluate its association with muscle mass and patient outcomes. A retrospective cohort study. A tertiary-care medical center. High-risk adult ICU patients from October 2008 to December 2010. The gold standard for muscle mass was quantified with the paraspinal muscle surface area at the L4 vertebrae in the subset of individuals with an abdominal CT scan. Using Pearson's correlation coefficient, serum creatinine-to-serum cystatin C ratio was found to be the best performer in the estimation of muscle mass. The relationship between sarcopenia index and hospital and 90-day mortality, and the length of mechanical ventilation was evaluated. Out of 226 enrolled patients, 123 (54%) were female, and 198 (87%) were white. Median (interquartile range) age, body mass index, and body surface area were 68 (57-77) years, 28 (24-34) kg/m, and 1.9 (1.7-2.2) m, respectively. The mean (± SD) Acute Physiology and Chronic Health Evaluation III was 70 (± 22). ICU, hospital, and 90-day mortality rates were 5%, 12%, and 20%, respectively. The correlation (r) between sarcopenia index and muscle mass was 0.62 and coefficient of determination (r) was 0.27 (p sarcopenia index was independently predictive of both hospital (p = 0.001) and 90-day mortality (p sarcopenia index (-1 d for each 10 unit of sarcopenia index [95% CI, -1.4 to -0.2; p = 0.006]). The sarcopenia index is a fair measure for muscle mass estimation among ICU patients and can modestly predict hospital and 90-day mortality among patients who do not have acute kidney injury at the time of measurement.

  20. Effect of creatine supplementation during rapid body mass reduction on metabolism and isokinetic muscle performance capacity.

    Science.gov (United States)

    Oöpik, V; Pääsuke, M; Timpmann, S; Medijainen, L; Ereline, J; Smirnova, T

    1998-06-01

    Well-trained subjects (n = 6) were studied before and after losing a mean 3.0%-4.3% of body mass to determine whether muscle performance could be maintained or even enhanced by dietary creatine supplementation. During a 5-day period of loss of mass the subjects were randomly assigned to a creatine or placebo supplemented diet. All the subjects were measured before and after loss of mass on both supplements for isokinetic peak torque (PT) and work at peak torque (W(PT)) of knee extensors, also for intermittent high intensity working capacity of the same muscle group. The latter test consisted of submaximal isokinetic knee extensions at an angular velocity of 1.57 rad x s(-1) for 45 s at the rate of 30 contractions each min (submaximal work, Ws max) followed by 15-s maximal effort (maximal work, Wmax). Total duration of the test was 3 min. Haematocrit was measured and haemoglobin, ammonia, lactate, glucose and urea concentrations were analysed in blood samples obtained at rest and after cessation of muscle performance tests. The results indicated that creatine supplementation in comparison with placebo treatment during rapid body mass reduction may help to maintain muscle PT and W(PT)1 at high angular velocities, not influencing Wmax and the rate of fatigue development during Wmax, but affecting adversely Ws max. Within the limitations of the present study the reasons for the partially detrimental effect of creatine administration remain obscure, but it is suggested that impaired creatine uptake in muscle during body mass loss as well as creatine induced changes in muscle glucose and glycogen metabolism may be involved.

  1. Pathobiochemical Changes in Diabetic Skeletal Muscle as Revealed by Mass-Spectrometry-Based Proteomics

    Directory of Open Access Journals (Sweden)

    Kay Ohlendieck

    2012-01-01

    Full Text Available Insulin resistance in skeletal muscle tissues and diabetes-related muscle weakness are serious pathophysiological problems of increasing medical importance. In order to determine global changes in the protein complement of contractile tissues due to diabetes mellitus, mass-spectrometry-based proteomics has been applied to the investigation of diabetic muscle. This review summarizes the findings from recent proteomic surveys of muscle preparations from patients and established animal models of type 2 diabetes. The potential impact of novel biomarkers of diabetes, such as metabolic enzymes and molecular chaperones, is critically examined. Disease-specific signature molecules may be useful for increasing our understanding of the molecular and cellular mechanisms of insulin resistance and possibly identify new therapeutic options that counteract diabetic abnormalities in peripheral organ systems. Importantly, the biomedical establishment of biomarkers promises to accelerate the development of improved diagnostic procedures for characterizing individual stages of diabetic disease progression, including the early detection of prediabetic complications.

  2. Loss of muscle mass: Current developments in cachexia and sarcopenia focused on biomarkers and treatment.

    Science.gov (United States)

    Drescher, Cathleen; Konishi, Masaaki; Ebner, Nicole; Springer, Jochen

    2016-01-01

    Loss of muscle mass arises from an imbalance of protein synthesis and protein degradation. Potential triggers of muscle wasting and function are immobilization, loss of appetite, dystrophies and chronic diseases as well as aging. All these conditions lead to increased morbidity and mortality in patients, which makes it a timely matter to find new biomarkers to get a fast clinical diagnosis and to develop new therapies. This mini-review covers current developments in the field of biomarkers and drugs on cachexia and sarcopenia. Here, we reported about promising markers, e.g. tartrate-resistant acid phosphatase 5a (TRACP5a), and novel substances like Epigallocatechin-3-gallate (EGCg). In summary, the progress to combat muscle wasting is in full swing and perhaps diagnosis of muscle atrophy and of course patient treatments could be soon supported by improved and more helpful strategies.

  3. Ultrasound assessment of lower limb muscle mass in response to resistance training in COPD

    Directory of Open Access Journals (Sweden)

    Menon Manoj K

    2012-12-01

    Full Text Available Abstract Background Quantifying the improvements in lower limb or quadriceps muscle mass following resistance training (RT, is an important outcome measure in COPD. Ultrasound is a portable, radiation free imaging technique that can measure the size of superficial muscles belonging to the quadriceps group such as the rectus femoris, but has not been previously used in COPD patients following RT. We compared the responsiveness of ultrasound derived measures of quadriceps mass against dual energy x-ray absorptiometry (DEXA, in patients with COPD and healthy controls following a programme of high intensity knee extensor RT. Methods Portable ultrasound was used to assess the size of the dominant quadriceps in 45 COPD patients and 19 healthy controls-before, during, and after 8 weeks of bilateral high intensity isokinetic knee extensor RT. Scanning was performed at the mid-thigh region, and 2 indices of quadriceps mass were measured-rectus femoris cross-sectional area (RFcsa and quadriceps muscle thickness (Qt. Thigh lean mass (Tdexa was determined by DEXA. Results Training resulted in a significant increase in Tdexa, RFcsa and Qt in COPD patients [5.7%, 21.8%, 12.1% respectively] and healthy controls [5.4%, 19.5%, 10.9 respectively]. The effect size for the changes in RFcsa (COPD= 0.77; Healthy=0.83 and Qt (COPD=0.36; Healthy=0.78 were greater than the changes in Tdexa (COPD=0.19; Healthy=0.26 following RT. Conclusions Serial ultrasound measurements of the quadriceps can detect changes in muscle mass in response to RT in COPD. The technique has good reproducibility, and may be more sensitive to changes in muscle mass when compared to DEXA. Trial registration http://www.controlled-trials.com (Identifier: ISRCTN22764439

  4. Increased fat mass, decreased myofiber size, and a shift to glycolytic muscle metabolism in adolescent male transgenic mice overexpressing IGFBP-2.

    Science.gov (United States)

    Rehfeldt, Charlotte; Renne, Ulla; Sawitzky, Mandy; Binder, Gerhard; Hoeflich, Andreas

    2010-08-01

    To elucidate the functional role of insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2) for in vivo skeletal muscle growth and function, skeletal muscle cellularity and metabolism, expression of signal molecules, and body growth and composition were studied in a transgenic mouse model overexpressing IGFBP-2. Postnatal growth rate of transgenic mice was reduced from day 21 of age by 6-8% compared with nontransgenic controls. At 10 wk of age body lean protein and moisture percentages were lower, whereas fat percentage was higher in IGFBP-2 transgenic mice. Muscle weights were reduced (-13% on day 30 of age, -14% on day 72), which resulted from slower growth of myofibers in size but not from decreases in myofiber number. The reduction in muscle mass was associated with lower total DNA, RNA, and protein contents as well as greater DNA/RNA and protein/RNA ratios. The percentage of proliferating (Ki-67-positive) nuclei within myofibers was reduced (3.4 vs. 5.8%) in 30-day-old transgenic mice. These changes were accompanied by slight reductions in specific p44/42 MAPK activity (-18% on day 72) and, surprisingly, by increased levels of phosphorylated Akt (Ser(473)) (+25% on day 30, +66% on day 72). The proportion of white glycolytic fibers (55.9 vs. 53.5%) and the activity of lactate dehydrogenase (+8%) were elevated in 72-day-old transgenic mice. Most of the differences observed between transgenic and nontransgenic mice were more pronounced in males. The results suggest that IGFBP-2 significantly inhibits postnatal skeletal myofiber growth by decreasing myogenic proliferation and protein accretion and enhances glycolytic muscle metabolism.

  5. Tissue Selective Androgen Receptor Modulators (SARMs) Increase Pelvic Floor Muscle Mass in Ovariectomized Mice.

    Science.gov (United States)

    Ponnusamy, Suriyan; Sullivan, Ryan D; Thiyagarajan, Thirumagal; Tillmann, Heather; Getzenberg, Robert H; Narayanan, Ramesh

    2017-03-01

    Stress urinary incontinence (SUI), a prevalent condition, is represented by an involuntary leakage of urine that results, at least in part, from weakened or damaged pelvic floor muscles and is triggered by physical stress. Current treatment options are limited with no oral therapies available. The pelvic floor is rich in androgen receptor and molecules with anabolic activity including selective androgen receptor modulators (SARMs) may serve as therapeutic options for individuals with SUI. In this study, two SARMs (GTx-024 and GTx-027) were evaluated in a post-menopausal animal model in order to determine their effect on pelvic floor muscles. Female C57BL/6 mice were ovariectomized and their pelvic muscles allowed to regress. The animals were then treated with vehicle or doses of GTx-024 or GTx-027. Animal total body weight, lean body mass, and pelvic floor muscle weights were measured along with the expression of genes associated with muscle catabolism. Treatment with the SARMs resulted in a restoration of the pelvic muscles to the sham-operated weight. Coordinately, the induction of genes associated with muscle catabolism was inhibited. Although a trend was observed towards an increase in total lean body mass in the SARM-treated groups, no significant differences were detected. Treatment of an ovariectomized mouse model with SARMs resulted in an increase in pelvic floor muscles, which may translate to an improvement of symptoms associated with SUI and serves as the basis for evaluating their clinical use. J. Cell. Biochem. 118: 640-646, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  6. Strength Exercise Improves Muscle Mass and Hepatic Insulin Sensitivity in Obese Youth

    NARCIS (Netherlands)

    Van Der Heijden, Gert-Jan; Wang, Zhiyue J.; Chu, Zili; Toffolo, Gianna; Manesso, Erica; Sauer, Pieter J. J.; Sunehag, Agneta L.

    2010-01-01

    VAN DER HEIJDEN, G.-J., Z. J. WANG, Z. CHU, G. TOFFOLO, E. MANESSO, P. J. J. SAUER, and A. L. SUNEHAG. Strength Exercise Improves Muscle Mass and Hepatic Insulin Sensitivity in Obese Youth. Med. Sci. Sports Exerc., Vol. 42, No. 11, pp. 1973-1980, 2010. Introduction: Data on the metabolic effects of

  7. Strength Exercise Improves Muscle Mass and Hepatic Insulin Sensitivity in Obese Youth

    NARCIS (Netherlands)

    Van Der Heijden, Gert-Jan; Wang, Zhiyue J.; Chu, Zili; Toffolo, Gianna; Manesso, Erica; Sauer, Pieter J. J.; Sunehag, Agneta L.

    2010-01-01

    VAN DER HEIJDEN, G.-J., Z. J. WANG, Z. CHU, G. TOFFOLO, E. MANESSO, P. J. J. SAUER, and A. L. SUNEHAG. Strength Exercise Improves Muscle Mass and Hepatic Insulin Sensitivity in Obese Youth. Med. Sci. Sports Exerc., Vol. 42, No. 11, pp. 1973-1980, 2010. Introduction: Data on the metabolic effects of

  8. Sarcopenia and liver transplant: The relevance of too little muscle mass

    Science.gov (United States)

    Kallwitz, Eric R

    2015-01-01

    Loss of muscle mass and function is a common occurrence in both patients with decompensated cirrhosis and those undergoing liver transplantation. Sarcopenia is associated with morbidity and mortality before and after liver transplantation. The ability of skeletal muscle mass to recover after transplant is questionable, and long term adverse events associated with persistent sarcopenia have not been well studied. Limited data is available examining mechanisms by which decreased muscle mass might develop. It is not clear which interventions might reduce the prevalence of sarcopenia and associated health burdens. However, measures to either decrease portal hypertension or improve nutrition appear to have benefit. Research on sarcopenia in the liver transplant setting is hampered by differing methodology to quantify muscle mass and varied thresholds determining the presence of sarcopenia. One area highlighted in this review is the heterogeneity used when defining sarcopenia. The health consequences, clinical course and potential pathophysiologic mechanisms of sarcopenia in the setting of cirrhosis and liver transplantation are further discussed. PMID:26494955

  9. Improved skeletal muscle mass and strength after heavy strength training in very old individuals

    DEFF Research Database (Denmark)

    Bechshøft, Rasmus Leidesdorff; Malmgaard-Clausen, Nikolaj Mølkjær; Gliese, Bjørn

    2017-01-01

    Age-related loss of muscle mass and function represents personal and socioeconomic challenges. The purpose of this study was to determine the adaptation of skeletal musculature in very old individuals (83 + years) performing 12 weeks of heavy resistance training (3 ×/week) (HRT) compared to a non...

  10. Dairy food intake, peripheral bone structure, and muscle mass in elderly ambulatory women.

    Science.gov (United States)

    Radavelli-Bagatini, Simone; Zhu, Kun; Lewis, Joshua R; Prince, Richard L

    2014-07-01

    Previous studies suggest that dairy intake may be associated with reduced bone and muscle loss with aging, but there are limited data in the very old. We evaluated the association between intake of dairy foods and peripheral bone structure and muscle mass in 564 elderly women aged 80 to 92 (mean 84.7) years, who were participants of the Calcium Intake Fracture Outcome Study/CAIFOS Aged Extension Study (CAIFOS/CARES) cohort and attended the 10-year follow-up. Assessments included dairy consumption (milk, yogurt, and cheese) by a validated food frequency questionnaire, 15% tibia bone mass, area and volumetric bone mineral density (vBMD) by peripheral quantitative computed tomography (pQCT), and appendicular bone and skeletal muscle mass by dual-energy X-ray absorptiometry (DXA). Women were categorized according to tertiles of dairy intake: first tertile (≤ 1.5 servings/d), second tertile (1.5 to 2.2 servings/d) and third tertile (≥ 2.2 servings/d). Controlling for confounding factors, pQCT assessment at the 15% tibia showed that compared with those in the first tertile of dairy intake, women in the third tertile had 5.7% greater total bone mass (p = 0.005), principally because of an increase in cortical and subcortical bone mass (5.9%, p = 0.050), resulting in a 6.2% increase in total vBMD (p = 0.013). Trabecular but not cortical and subcortical vBMD was also higher (7.8%, p = 0.044). DXA assessment showed that women in the third tertile of dairy intake had greater appendicular bone mass (7.1%, p = 0.007) and skeletal muscle mass (3.3%, p = 0.014) compared with tertile 1. The associations with bone measures were dependent on dairy protein and calcium intakes, whereas the association with appendicular muscle mass was not totally dependent on dairy protein intake. Our results suggest a positive association of dairy intake with appendicular bone mineralization and muscle mass in elderly women. Because many fractures in this age group are of the appendicular skeleton

  11. The Self-Similarity of the Circumgalactic Medium with Galaxy Virial Mass: Implications for Cold-Mode Accretion

    CERN Document Server

    Churchill, Christopher W; Kacprzak, Glenn G; Trujillo-Gomez, Sebastian

    2013-01-01

    We apply halo abundance matching to obtain galaxy virial masses, M_h, and radii, Rvir, for the 169 isolated galaxies in the "MgII Absorber-Galaxy Catalog" (MAGIICAT, Nielsen et al.). All galaxies have spectroscopic redshifts (0.1 < z < 1.1) and their circumgalactic medium (CGM) is probed in MgII absorption within projected galactocentric distances D < 200 kpc. We examine the behavior of equivalent width, W(2796), and covering fraction, f_c, as a function of D, D/Rvir, and M_h. We find: [1] systematic segregation of M_h on the W(2796)-D plane (4.2 sigma); high-mass halos are found at higher D with larger W(2796) compared to lower mass halos. On the W(2796)-D/Rvir plane, mass segregation vanishes and we find W(2796) ~ (D/Rvir)^-2 (9.5 sigma); [2] higher mass halos have larger f_c at a given D, whereas f_c is independent of M_h at all D/Rvir; [3] f_c is constant with M_h over the range 10.4 < log(M_h/Msun) < 13.3 within a given D or D/Rvir. The combined results suggest that the MgII absorbing CGM ...

  12. Testing the Paradigm that Ultra-Luminous X-ray Sources as a Class Represent Accreting Intermediate-Mass Black Holes

    CERN Document Server

    Berghea, C T; Colbert, E J M; Roberts, T P

    2008-01-01

    To test the idea that ultraluminous X-ray sources (ULXs) in external galaxies represent a class of accreting Intermediate-Mass Black Holes (IMBHs), we have undertaken a program to identify ULXs and a lower luminosity X-ray comparison sample with the highest quality data in the {\\it Chandra} archive. We establish a general property of ULXs that the most X-ray luminous objects possess the flattest X-ray spectra (in the {\\it Chandra} band pass). No prior sample studies have established the general hardening of ULX spectra with luminosity. This hardening occurs at the highest luminosities (absorbed luminosity $\\geq5\\times10^{39}$ erg s$^{-1}$) and is in line with recent models arguing that ULXs are actually stellar-mass black holes. From spectral modeling, we show that the evidence originally taken to mean that ULXs are IMBHs - i.e., the ``simple IMBH model'' - is nowhere near as compelling when a large sample of ULXs is looked at properly. During the last couple of years, {\\it XMM-Newton} spectroscopy of ULXs ha...

  13. New Planetary Systems from the Calan-Hertfordshire Extrasolar Planet Search and the Core Accretion Mass Limit

    CERN Document Server

    Jenkins, J S; Tuomi, M; Díaz, M; Cordero, J P; Aguayo, A; Pantoja, B; Arriagada, P; Mahu, R; Brahm, R; Rojo, P; Soto, M G; Ivanyuk, O; Yoma, N Becerra; Day-Jones, A C; Ruiz, M T; Pavlenko, Y V; Barnes, J R; Murgas, F; Pinfield, D J; Jones, M I; López-Morales, M; Shectman, S; Butler, R P; Minniti, D

    2016-01-01

    We report the discovery of eight new giant planets, and updated orbits for four known planets, orbiting dwarf and subgiant stars, using the CORALIE, HARPS, and MIKE instruments as part of the Calan-Hertfordshire Extrasolar Planet Search. We include radial velocity data prior- and post-2014 CORALIE upgrade and our Bayesian updating method returned a systematic offset of 19.2$\\pm$4.8 m/s between the two velocity sets for our stars. The planets have masses in the range 1.1-5.4M$_{\\rm{J}}$s, orbital periods from 40-2900 days, and eccentricities from 0.0-0.6. They include a double-planet system orbiting the most massive star in our sample (HD147873), two eccentric giant planets (HD128356$b$ and HD154672$b$), and a rare 14~Herculis analogue (HD224538$b$). We find that there is an over-abundance of Jupiter-mass objects compared to a simple power law fit to the mass function, with a steep increase in the planet frequency around 3M$_{\\rm{J}}$, reflecting the increased efficiency of planet formation towards lower masse...

  14. Decreased β-Cell Function Is Associated with Reduced Skeletal Muscle Mass in Japanese Subjects without Diabetes

    Science.gov (United States)

    Sakai, Satoshi; Tanimoto, Keiji; Imbe, Ayumi; Inaba, Yuiko; Shishikura, Kanako; Tanimoto, Yoshimi; Ushiroyama, Takahisa; Terasaki, Jungo; Hanafusa, Toshiaki

    2016-01-01

    Background Decreased insulin secretion has a great impact on the incidence of type 2 diabetes in Japanese subjects. It is not clear whether β-cell function is related to muscle mass in subjects without diabetes. We investigated the relationship between β-cell function and skeletal muscle mass in Japanese subjects without diabetes. Methods The study included 1098 subjects (538 men and 560 women) aged 40 to 79 years, without diabetes (fasting glucose lower than 126 mg/dL and glycosylated hemoglobin lower than 6.5%), who consulted Osaka Medical College Health Science Clinic for a medical examination. Appendicular muscle mass was measured by bioelectrical impedance analysis. Appendicular muscle mass index was calculated as appendicular muscle mass divided by height squared (kg/m2). The homeostatic model assessment of β-cell function was used to assess β-cell function. The homeostatic model assessment of insulin resistance was used as a measure of insulin resistance. The association between appendicular muscle mass index and clinical parameters of β-cell function and insulin resistance was examined. Results Log-transformed homeostatic model assessment of β-cell function and Log-transformed homeostatic model assessment of insulin resistance showed a normal distribution. In both men and women, there was a significant positive correlation between appendicular muscle mass index and clinical parameters of β-cell function and insulin resistance. Tertile analysis, following stratification according to appendicular muscle mass index, found that low appendicular muscle mass index was significantly associated with the Log homeostatic model assessment of β-cell function and Log-transformed homeostatic model assessment of insulin resistance. Conclusion This study shows that decreased β cell function is associated with reduced skeletal muscle mass in Japanese subjects without diabetes. PMID:27612202

  15. A 15-Year-Old Male Baseball Player With a Mass in the Brachialis Muscle.

    Science.gov (United States)

    Golub, Ivan J; Garcia, Roberto A; Wittig, James C

    2016-05-01

    A 15-year-old boy presented with a mass in his right arm after suffering a minor injury playing baseball. He had been diagnosed with a hematoma. There was no other outstanding medical/surgical history. Magnetic resonance images showed a heterogeneous mass arising from the brachialis muscle that mainly enhanced peripherally with extremely scant internal nodular enhancement. Core needle biopsy cells were positive for CD31 and CD34, markers for atypical endothelial cells, as well as MIB-1 and p53. The final diagnosis was an angiosarcoma of the brachialis muscle. Pediatric angiosarcoma, particularly within deep tissue, is exceedingly rare. Histological and immunohistochemical modalities led to the diagnosis. Magnetic resonance images suggested a mass with a large cystic/hemorrhagic space that could have been misconstrued as a hematoma had there been absolutely no nodular or septal enhancement. The patient underwent neoadjuvant chemotherapy and radiation before undergoing limb-sparing surgery that included resection of the mass with the brachialis muscle and short head of the biceps muscle. Neoadjuvant treatment was deemed successful due to a drastic reduction in the size of the tumor and 95% tumor necrosis. The patient was disease free 2 years postoperatively. There had been no local/systemic recurrences. He was pain free, had normal elbow function, and had returned to playing baseball. It is important to be extremely suspicious when a patient presents with a hemorrhagic, painless, enlarging mass after sustaining minor trauma. A careful and meticulous biopsy must be completed to achieve the correct diagnosis. Magnetic resonance imaging with gadolinium is recommended for evaluation because these masses can be often misinterpreted as hematomas. [Orthopedics. 2016; 39(3):e545-e548.].

  16. Accretion of the Earth.

    Science.gov (United States)

    Canup, Robin M

    2008-11-28

    The origin of the Earth and its Moon has been the focus of an enormous body of research. In this paper I review some of the current models of terrestrial planet accretion, and discuss assumptions common to most works that may require re-examination. Density-wave interactions between growing planets and the gas nebula may help to explain the current near-circular orbits of the Earth and Venus, and may result in large-scale radial migration of proto-planetary embryos. Migration would weaken the link between the present locations of the planets and the original provenance of the material that formed them. Fragmentation can potentially lead to faster accretion and could also damp final planet orbital eccentricities. The Moon-forming impact is believed to be the final major event in the Earth's accretion. Successful simulations of lunar-forming impacts involve a differentiated impactor containing between 0.1 and 0.2 Earth masses, an impact angle near 45 degrees and an impact speed within 10 per cent of the Earth's escape velocity. All successful impacts-with or without pre-impact rotation-imply that the Moon formed primarily from material originating from the impactor rather than from the proto-Earth. This must ultimately be reconciled with compositional similarities between the Earth and the Moon.

  17. Photometric Determination of the Mass Accretion Rates of Pre-main-sequence Stars. V. Recent Star Formation in the 30 Dor Nebula

    Science.gov (United States)

    De Marchi, Guido; Panagia, Nino; Beccari, Giacomo

    2017-09-01

    We report on the properties of the low-mass stars that recently formed in the central ∼ 2\\buildrel{ \\prime}\\over{.} 7× 2\\buildrel{ \\prime}\\over{.} 7 of 30 Dor, including the R136 cluster. Using the photometric catalog of De Marchi et al., based on observations with the Hubble Space Telescope, and the most recent extinction law for this field, we identify 1035 bona fide pre-main-sequence (PMS) stars showing {{H}}α excess emission at the 4σ level with an {{H}}α equivalent width of 20 Å or more. We find a wide spread in age spanning the range ∼ 0.1{--}50 {Myr}. We also find that the older PMS objects are placed in front of the R136 cluster and are separated from it by a conspicuous amount of absorbing material, indicating that star formation has proceeded from the periphery into the interior of the region. We derive physical parameters for all PMS stars, including masses m, ages t, and mass accretion rates {\\dot{M}}{acc}. To identify reliable correlations between these parameters, which are intertwined, we use a multivariate linear regression fit of the type {log}{\\dot{M}}{acc}=a× {log}t+b× {log}m+c. The values of a and b for 30 Dor are compatible with those found in NGC 346 and NGC 602. We extend the fit to a uniform sample of 1307 PMS stars with 0.5contract NAS5-26555.

  18. Chandra and MMT observations of low-mass black hole active galactic nuclei accreting at low rates in dwarf galaxies

    CERN Document Server

    Yuan, W; Dou, L; Dong, X -B; Fan, X; Wang, T -G

    2014-01-01

    We report on Chandra X-ray observations of four candidate low-mass black hole (<10^6Msun) active galactic nuclei (AGNs) that have the estimated Eddington ratios among the lowest (~10^(-2)) found for this class. The aims are to validate the nature of their AGNs and to confirm the low Eddington ratios that are derived from the broad H_alpha line, and to explore this poorly studied regime in the AGN parameter space. Among them, two objects with the lowest significance of the broad lines are also observed with Multi-Mirror Telescope, and the high-quality optical spectra taken confirm them as Seyfert 1 AGNs and as having small black hole masses. X-ray emission is detected from the nuclei of two of the galaxies, which is variable on timescales of 10^3s, whereas no significant (or only marginal at best) detection is found for the remaining two. The X-ray luminosities are on the order of 10^(41) ergs/s or even lower, on the order of 10^(40) ergs/s for non-detections, which are among the lowest regimes ever probed ...

  19. Pycnonuclear burning and accreting neutron stars

    CERN Document Server

    Yakovlev, D G

    2002-01-01

    We outline the phenomenon of deep crustal heating in transiently accreting neutron stars. It is produced by nuclear transformations (mostly, by pycnonuclear reactions) in accreted matter while this matter sinks to densities rho > 10^{10} g/cc under the weight of freshly accreted material. We consider then thermal states of transiently accreting neutron stars (with mean mass accretion rates \\dot{M}=(10^{-14}-10^{-9}) M_\\odot/yr) determined by deep crustal heating. In a simplified fashion we study how the thermal flux emergent from such stars depends on the properties of superdense matter in stellar interiors. We analyze the most important regulators of the thermal flux: strong superfluidity in the cores of low-mass stars and fast neutrino emission (in nucleon, pion-condensed, kaon-condensed, or quark phases of dense matter) in the cores of high-mass stars. We compare the results with observations of soft X-ray transients in quiescent states.

  20. Protein needs in athletes and dietary-nutrition guidelines to gain muscle mass

    Directory of Open Access Journals (Sweden)

    Aritz Urdampilleta

    2014-05-01

    Full Text Available One of the most important effects of strength training is muscular hypertrophy. Athletes should optimize their nutritional management in order to compensate their own genetic limitations. The aim of this review is to analyze the scientific evidence concerning protein intake as a tool to achieve muscle hypertrophy. Depending on the expenditure and energy intake of athlete, a daily protein ranging between 10-15% of total dietary intake is needed. However in sports diets, it is preferable to estimate the amount of protein needed per kilogram of body weight in each individual. In this regard athletes should ingest an amount between 1.2 g and 1.8 g of proteins/kg of body mass/day to maintain their lean mass. In order to increase muscle mass (0.5 kg/week, athletes should take between 1.6 g and 1.8 g of protein/kg/day with an increase of 400-500 kcal in their daily diet. These needs will depend on the sport, muscular catabolic status, the athlete’s lean mass and glycogen stores. Protein needs will increase if muscle and liver glycogen stores are empty. Excess of protein intake (more than 2 g/kg/day, with full glycogen stores, does not benefit the athlete and could cause an increase in circulating ketones and urea, thereby producing an early dehydration.

  1. A cold neutron star in the transient low-mass X-ray binary HETE J1900.1-2455 after 10 years of active accretion

    CERN Document Server

    Degenaar, N; Reynolds, M T; Wijnands, R; Page, D

    2016-01-01

    The neutron star low-mass X-ray binary and intermittent millisecond X-ray pulsar HETE J1900.1-2455 returned to quiescence in late 2015, after a prolonged accretion outburst of ~10 yr. Using a Chandra observation taken ~180 d into quiescence we detect the source at a luminosity of ~4.5E31 (D/4.7 kpc)^2 erg/s (0.5-10 keV). The X-ray spectrum can be described by a neutron star atmosphere model with a temperature of ~54 eV for an observer at infinity. We perform thermal evolution calculations based on the 2016 quiescent data and a <98 eV temperature upper limit inferred from a Swift observation taken during an unusually brief (<2 weeks) quiescent episode in 2007. We find no evidence in the present data that the thermal properties of the crust, such as the heating rate and thermal conductivity, are different than those of non-pulsating neutron stars. Finding this neutron star so cold after its long outburst imposes interesting constraints on the heat capacity of the stellar core; these become even stronger i...

  2. A High-Resolution Multiband Survey of Westerlund 2 With the Hubble Space Telescope. II. Mass accretion in the Pre-Main Sequence Population

    CERN Document Server

    Zeidler, Peter; Nota, Antonella; Sabbi, Elena; Pasquali, Anna; Tosi, Monica; Bonanos, Alceste Z; Christian, Carol

    2016-01-01

    We present a detailed analysis of the pre-main-sequence (PMS) population of the young star cluster Westerlund~2 (Wd2), the central ionizing cluster of the HII region RCW 49, using data from a high resolution multi-band survey with the Hubble Space Telescope. The data were acquired with the Advanced Camera for Surveys in the F555W, F814W, and F658N filters and with the Wide Field Camera 3 in the F125W, F160W, and F128N filters. We find a mean age of the region of 1.04+-0.72 Myr. The combination of dereddened F555W and F814W photometry in combination with F658N photometry allows us to study and identify stars with H_alpha excess emission. With a careful selection of 240 bona-fide PMS H_alpha excess emitters we were able to determine their H_alpha luminosity, which has a mean value L(H_alpha)=1.67 x 10^{-31} erg s^{-1}. Using the PARSEC 1.2S isochrones to obtain the stellar parameters of the PMS stars we determined a mean mass accretion rate \\dot M_acc=4.43 x 10^{-8} M_sun yr^{-1} per star. A careful analysis of...

  3. A cold neutron star in the transient low-mass X-ray binary HETE J1900.1-2455 after 10 yr of active accretion

    Science.gov (United States)

    Degenaar, N.; Ootes, L. S.; Reynolds, M. T.; Wijnands, R.; Page, D.

    2017-02-01

    The neutron star low-mass X-ray binary and intermittent millisecond X-ray pulsar HETE J1900.1-2455 returned to quiescence in late 2015, after a prolonged accretion outburst of ≃10 yr. Using a Chandra observation taken ≃180 d into quiescence, we detect the source at a luminosity of ≃4.5 × 1031 (D/4.7 kpc)2 erg s-1 (0.5-10 keV). The X-ray spectrum can be described by a neutron star atmosphere model with a temperature of ≃54 eV for an observer at infinity. We perform thermal evolution calculations based on the 2016 quiescent data and a ≲98 eV temperature upper limit inferred from a Swift observation taken during an unusually brief (≲2 weeks) quiescent episode in 2007. We find no evidence in the present data that the thermal properties of the crust, such as the heating rate and thermal conductivity, are different than those of non-pulsating neutron stars. Finding this neutron star so cold after its long outburst imposes interesting constraints on the heat capacity of the stellar core; these become even stronger if further cooling were to occur.

  4. Mass dynamics of wintering Pacific Black Brant: Body, adipose tissue, organ, and muscle masses vary with location

    Science.gov (United States)

    Mason, D.D.; Barboza, P.S.; Ward, D.H.

    2007-01-01

    We compared body size and mass of the whole body, organs, adipose tissue, and muscles of adult Pacific Black Brant (Branta bernicla nigricans (Lawrence, 1846)) collected concurrently in Alaska and Baja California during the fall, winter, and spring of 2002–2003. Head and tarsal lengths of males were similar between sites and slightly larger for females in Alaska than in Baja California. Brant appear to operate under similar physiological bounds, but patterns of nutrient allocation differ between sites. Birds wintering in Alaska lost similar amounts of adipose tissue during early winter as birds in Baja California gained during late winter before migration. Masses of the body, adipose tissue, and flight muscles during mid-winter were similar between sites. Seasonal adipose tissue deposition may, therefore, equally favor winter residency or long-distance migration. Gonad and liver masses increased in late winter for birds in Alaska but not for those in Baja California, suggesting birds wintering in Baja may delay reproductive development in favor of allocating reserves needed for migration. Phenotypic flexibility allows Brant to use widely divergent wintering sites. The wintering location of Brant likely depends more upon changes in environmental conditions and food availability, than upon physiological differences between the two wintering populations.

  5. Impact of initial models and variable accretion rates on the pre-main-sequence evolution of massive and intermediate-mass stars and the early evolution of H II regions

    Science.gov (United States)

    Haemmerlé, Lionel; Peters, Thomas

    2016-05-01

    Massive star formation requires the accretion of gas at high rate while the star is already bright. Its actual luminosity depends sensitively on the stellar structure. We compute pre-main-sequence tracks for massive and intermediate-mass stars with variable accretion rates and study the evolution of stellar radius, effective temperature and ionizing luminosity, starting at 2 M⊙ with convective or radiative structures. The radiative case shows a much stronger swelling of the protostar for high accretion rates than the convective case. For radiative structures, the star is very sensitive to the accretion rate and reacts quickly to accretion bursts, leading to considerable changes in photospheric properties on time-scales as short as 100-1000 yr. The evolution for convective structures is much less influenced by the instantaneous accretion rate, and produces a monotonically increasing ionizing flux that can be many orders of magnitude smaller than in the radiative case. For massive stars, it results in a delay of the H II region expansion by up to 10 000 yr. In the radiative case, the H II region can potentially be engulfed by the star during the swelling, which never happens in the convective case. We conclude that the early stellar structure has a large impact on the radiative feedback during the pre-main-sequence evolution of massive protostars and introduces an important uncertainty that should be taken into account. Because of their lower effective temperatures, our convective models may hint at a solution to an observed discrepancy between the luminosity distribution functions of massive young stellar objects and compact H II regions.

  6. Ultrasonographic evaluation of the calf muscle mass and architecture in elderly patients with and without sarcopenia.

    Science.gov (United States)

    Kuyumcu, Mehmet Emin; Halil, Meltem; Kara, Özgür; Çuni, Bledjan; Çağlayan, Gökhan; Güven, Serdar; Yeşil, Yusuf; Arık, Güneş; Yavuz, Burcu Balam; Cankurtaran, Mustafa; Özçakar, Levent

    2016-01-01

    To sonographically assess the muscle mass and architecture of sarcopenic elderly subjects, and to explore the utility of ultrasound (US) measurements in predicting sarcopenia. One hundred elderly subjects were enrolled in this cross-sectional study. Mean age value of our study population was 73.08±6.18years. The diagnosis of sarcopenia was confirmed by measuring fat-free mass index (using bioelectrical impedance analysis) and handgrip strength. Calf circumference was measured and US evaluations comprised bilateral gastrocnemius muscle (MG) thickness, fascicle length and pennate angles; subcutaneous fat and dermis thicknesses in the calf. Bilateral muscle thickness and fascicle length values were significantly lower in patients with sarcopenia (both psarcopenia (all values>76.92%). Gastrocnemius muscle thickness and fascicle length values are lower in sarcopenic elderly and these two parameters can serve as alternative measurements for predicting/quantifying sarcopenia. Calf circumference measurements alone may not be appropriate for assessing sarcopenia. Instead, US imaging can conveniently be used to evaluate different compartments of the musculoskelal system in (sarcopenic) elderly. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  7. Interpreting MAD within multiple accretion regimes

    CERN Document Server

    Mocz, Philip

    2014-01-01

    General relativistic magnetohydrodynamic (GRMHD) simulations of accreting black holes in the radiatively inefficient regime show that systems with sufficient magnetic poloidal flux become magnetically arrested disc (MAD) systems, with a well-defined relationship between the magnetic flux and the mass accretion rate. Recently, Zamaninasab (2014) report that the jet magnetic flux and accretion disc luminosity are tightly correlated over 7 orders of magnitude for a sample of 76 radio-loud active galaxies, concluding that the data are explained by the MAD mode of accretion. Their analysis assumes radiatively efficient accretion, and their sample consists primarily of radiatively efficient sources, while GRMHD simulations of MAD thus far have been carried out in the radiatively inefficient regime. We propose a model to interpret MAD systems in the context of multiple accretion regimes, and apply it to the sample in Zamaninasab (2014), along with additional radiatively inefficient sources from archival data. We sho...

  8. Muscle contributions to center of mass excursion in ankle and hip strategies during forward body tilting.

    Science.gov (United States)

    Ogaya, Shinya; Okita, Yusuke; Fuchioka, Satoshi

    2016-10-03

    Humans employ two distinct strategies to maintain balance during standing: the ankle and hip strategies. People with a high fall risk tend to alter their motion patterns during forward body tilting from a hip to an ankle strategy. Improved knowledge regarding how muscles control the center of mass (COM) during balancing would facilitate clinical assessment. The present study aimed to investigate individual muscle contributions to COM motion during forward body tilting with both ankle and hip strategies in 16 healthy adults. While standing, participants were instructed to oscillate their bodies and touch anterior and posterior targets at 0.5Hz. The anterior target was positioned at the sternum height level in a HIGH and 5% lower in a LOW condition to induce ankle and hip strategies, respectively. The muscle tension force was calculated from measured angle data using a two-dimensional, muscle-driven forward simulation model. Muscle contributions to COM acceleration during forward body tilting were calculated via induced acceleration analysis. Long hamstrings were found to increase upward-contributing action and forward COM acceleration in the LOW condition during forward tilting. In contrast, the contribution of the soleus to backward COM acceleration was reduced. These results imply that the contribution of hamstrings to forward COM acceleration is disadvantageous to fore-aft COM control and balance recovery during forward body tilting.

  9. Dynamical Accretion of Primordial Atmospheres around Planets with Masses between 0.1 and 5 M ⊕ in the Habitable Zone

    Science.gov (United States)

    Stökl, Alexander; Dorfi, Ernst A.; Johnstone, Colin P.; Lammer, Helmut

    2016-07-01

    In the early, disk-embedded phase of evolution of terrestrial planets, a protoplanetary core can accumulate gas from the circumstellar disk into a planetary envelope. In order to relate the accumulation and structure of this primordial atmosphere to the thermal evolution of the planetary core, we calculated atmosphere models characterized by the surface temperature of the core. We considered cores with masses between 0.1 and 5 M ⊕ situated in the habitable zone around a solar-like star. The time-dependent simulations in 1D-spherical symmetry include the hydrodynamics equations, gray radiative transport, and convective energy transport. Using an implicit time integration scheme, we can use large time steps and and thus efficiently cover evolutionary timescales. Our results show that planetary atmospheres, when considered with reference to a fixed core temperature, are not necessarily stable, and multiple solutions may exist for one core temperature. As the structure and properties of nebula-embedded planetary atmospheres are an inherently time-dependent problem, we calculated estimates for the amount of primordial atmosphere by simulating the accretion process of disk gas onto planetary cores and the subsequent evolution of the embedded atmospheres. The temperature of the planetary core is thereby determined from the computation of the internal energy budget of the core. For cores more massive than about one Earth mass, we obtain that a comparatively short duration of the disk-embedded phase (˜105 years) is sufficient for the accumulation of significant amounts of hydrogen atmosphere that are unlikely to be removed by later atmospheric escape processes.

  10. Accurate Quantitation of Dystrophin Protein in Human Skeletal Muscle Using Mass Spectrometry

    OpenAIRE

    Brown, Kristy J; Marathi, Ramya; Fiorillo, Alyson A; Ciccimaro, Eugene F.; Sharma, Seema; Rowlands, David S.; Rayavarapu, Sree; Nagaraju, Kanneboyina; Eric P. Hoffman; Hathout, Yetrib

    2012-01-01

    Quantitation of human dystrophin protein in muscle biopsies is a clinically relevant endpoint for both diagnosis and response to dystrophin-replacement therapies for dystrophinopathies. A robust and accurate assay would enable the use of dystrophin as a surrogate biomarker, particularly in exploratory Phase 2 trials. Currently available methods to quantitate dystrophin rely on immunoblot or immunohistochemistry methods that are not considered robust. Here we present a mass spectrometry based ...

  11. Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats.

    Science.gov (United States)

    Shankaran, Mahalakshmi; Shearer, Todd W; Stimpson, Stephen A; Turner, Scott M; King, Chelsea; Wong, Po-Yin Anne; Shen, Ying; Turnbull, Philip S; Kramer, Fritz; Clifton, Lisa; Russell, Alan; Hellerstein, Marc K; Evans, William J

    2016-03-15

    Biomarkers of muscle protein synthesis rate could provide early data demonstrating anabolic efficacy for treating muscle-wasting conditions. Androgenic therapies have been shown to increase muscle mass primarily by increasing the rate of muscle protein synthesis. We hypothesized that the synthesis rate of large numbers of individual muscle proteins could serve as early response biomarkers and potentially treatment-specific signaling for predicting the effect of anabolic treatments on muscle mass. Utilizing selective androgen receptor modulator (SARM) treatment in the ovariectomized (OVX) rat, we applied an unbiased, dynamic proteomics approach to measure the fractional synthesis rates (FSR) of 167-201 individual skeletal muscle proteins in triceps, EDL, and soleus. OVX rats treated with a SARM molecule (GSK212A at 0.1, 0.3, or 1 mg/kg) for 10 or 28 days showed significant, dose-related increases in body weight, lean body mass, and individual triceps but not EDL or soleus weights. Thirty-four out of the 94 proteins measured from the triceps of all rats exhibited a significant, dose-related increase in FSR after 10 days of SARM treatment. For several cytoplasmic proteins, including carbonic anhydrase 3, creatine kinase M-type (CK-M), pyruvate kinase, and aldolase-A, a change in 10-day FSR was strongly correlated (r(2) = 0.90-0.99) to the 28-day change in lean body mass and triceps weight gains, suggesting a noninvasive measurement of SARM effects. In summary, FSR of multiple muscle proteins measured by dynamics of moderate- to high-abundance proteins provides early biomarkers of the anabolic response of skeletal muscle to SARM.

  12. Androgen signaling in myocytes contributes to the maintenance of muscle mass and fiber type regulation but not to muscle strength or fatigue.

    Science.gov (United States)

    Ophoff, Jill; Van Proeyen, Karen; Callewaert, Filip; De Gendt, Karel; De Bock, Katrien; Vanden Bosch, An; Verhoeven, Guido; Hespel, Peter; Vanderschueren, Dirk

    2009-08-01

    Muscle frailty is considered a major cause of disability in the elderly and chronically ill. However, the exact role of androgen receptor (AR) signaling in muscle remains unclear. Therefore, a postmitotic myocyte-specific AR knockout (mARKO) mouse model was created and investigated together with a mouse model with ubiquitous AR deletion. Muscles from mARKO mice displayed a marked reduction in AR protein (60-88%). Interestingly, body weights and lean body mass were lower in mARKO vs. control mice (-8%). The weight of the highly androgen-sensitive musculus levator ani was significantly reduced (-46%), whereas the weights of other peripheral skeletal muscles were not or only slightly reduced. mARKO mice had lower intra-abdominal fat but did not demonstrate a cortical or trabecular bone phenotype, indicating that selective ablation of the AR in myocytes affected male body composition but not skeletal homeostasis. Furthermore, muscle contractile performance in mARKO mice did not differ from their controls. Myocyte-specific AR ablation resulted in a conversion of fast toward slow fibers, without affecting muscle strength or fatigue. Similar results were obtained in ubiquitous AR deletion, showing lower body weight, whereas some but not all muscle weights were reduced. The percent slow fibers was increased, but no changes in muscle strength or fatigue could be detected. Together, our findings show that myocyte AR signaling contributes to the maintenance of muscle mass and fiber type regulation but not to muscle strength or fatigue. The levator ani weight remains the most sensitive and specific marker of AR-mediated anabolic action on muscle.

  13. Depression Is Associated With Muscle Mass And Strength In Patients With End Stage Renal Disease

    Directory of Open Access Journals (Sweden)

    Young Rim Song

    2012-06-01

    Full Text Available Depression is the most common psychiatric complication in patients with end-stage renal disease (ESRD. Sarcopenia, defined as loss of muscle mass and strength, is expected to be associated with depression, because both are closely linked to physical inactivity and functional impairment. We investigated the association of sarcopenia with depression in patients with ESRD. A total of 115 patients undergoing hemodialysis (HD were included in this study. Muscle mass was assessed by lean tissue index (LTI using portable whole body bioimpedance spectroscopy, and muscle strength was measured with handgrip strength (HGS. Depression was defined as Beck Depression Inventory-II (BDI-II score ≥16. About 60% of prevalent HD patients had depression. Compared to subjects without depression, depressed patients had a higher prevalence of sarcopenia (45.5 vs. 8.2%, p<0.001 and significantly increased serum IL-6 and hs-CRP level. However, (prealbumin and body mass index (BMI failed to correlate with BDI-II. HGS and LTI had a consistent negative effect on BDI-II even after adjusting other parameters including inflammation. In multivariate analysis, lower , increased IL-6 and β2-microglobulin,and sarcopenia were significant predictors for depression; sarcopenia was most powerful [odds ratio 9.01, 95% CI 3.60-12.22, p=0.001]. In conclusion, the prevalence of sarcopenia and depression was considerably high and and the presence of sarcopenia was an important predictor for depression.

  14. Type VI collagen turnover-related peptides—novel serological biomarkers of muscle mass and anabolic response to loading in young men

    DEFF Research Database (Denmark)

    Nedergaard, Anders; Sun, Shu; Karsdal, Morten A

    2013-01-01

    Immobilization-induced loss of muscle mass is a complex phenomenon with several parallels to sarcopenic and cachectic muscle loss. Muscle is a large organ with a protein turnover that is orders of magnitude larger than most other tissues. Thus, we hypothesize that muscle loss and regain is reflec......Immobilization-induced loss of muscle mass is a complex phenomenon with several parallels to sarcopenic and cachectic muscle loss. Muscle is a large organ with a protein turnover that is orders of magnitude larger than most other tissues. Thus, we hypothesize that muscle loss and regain...... is reflected by peptide biomarkers derived from type VI collagen processing released in the circulation....

  15. Testosterone therapy increased muscle mass and lipid oxidation in aging men

    DEFF Research Database (Denmark)

    Frederiksen, Louise; Højlund, Kurt; Hougaard, David M

    2011-01-01

    .92). Testosterone therapy increased muscle mass and lipid oxidation in aging men with low normal bioavailable testosterone levels; however, our data did not support an effect of testosterone on whole-body insulin sensitivity using the euglycemic hyperinsulinemic clamp technique.......-stimulated glucose disposal (Rd) and substrate oxidation were assessed by euglycemic hyperinsulinemic clamps combined with indirect calorimetry. Lean body mass (LBM) and total fat mass (TFM) were measured by dual x-ray absorptiometry, and serum total testosterone was measured by tandem mass spectrometry....... Bioavailable testosterone was calculated. Coefficients (b) represent the placebo-controlled mean effect of intervention. LBM (b = 1.9 kg, p = 0.003) increased while HDL-cholesterol (b = -0.12 mmol/l, p = 0.043) and TFM decreased (b = -1.2 kg, p = 0.038) in the testosterone group compared to placebo. Basal...

  16. Time-Course of Muscle Mass Loss, Damage, and Proteolysis in Gastrocnemius following Unloading and Reloading: Implications in Chronic Diseases

    Science.gov (United States)

    Chacon-Cabrera, Alba; Lund-Palau, Helena; Gea, Joaquim; Barreiro, Esther

    2016-01-01

    Background Disuse muscle atrophy is a major comorbidity in patients with chronic diseases including cancer. We sought to explore the kinetics of molecular mechanisms shown to be involved in muscle mass loss throughout time in a mouse model of disuse muscle atrophy and recovery following immobilization. Methods Body and muscle weights, grip strength, muscle phenotype (fiber type composition and morphometry and muscle structural alterations), proteolysis, contractile proteins, systemic troponin I, and mitochondrial content were assessed in gastrocnemius of mice exposed to periods (1, 2, 3, 7, 15 and 30 days) of non-invasive hindlimb immobilization (plastic splint, I cohorts) and in those exposed to reloading for different time-points (1, 3, 7, 15, and 30 days, R cohorts) following a seven-day period of immobilization. Groups of control animals were also used. Results Compared to non-exposed controls, muscle weight, limb strength, slow- and fast-twitch cross-sectional areas, mtDNA/nDNA, and myosin content were decreased in mice of I cohorts, whereas tyrosine release, ubiquitin-proteasome activity, muscle injury and systemic troponin I levels were increased. Gastrocnemius reloading following splint removal improved muscle mass loss, strength, fiber atrophy, injury, myosin content, and mtDNA/nDNA, while reducing ubiquitin-proteasome activity and proteolysis. Conclusions A consistent program of molecular and cellular events leading to reduced gastrocnemius muscle mass and mitochondrial content and reduced strength, enhanced proteolysis, and injury, was seen in this non-invasive mouse model of disuse muscle atrophy. Unloading of the muscle following removal of the splint significantly improved the alterations seen during unloading, characterized by a specific kinetic profile of molecular events involved in muscle regeneration. These findings have implications in patients with chronic diseases including cancer in whom physical activity may be severely compromised. PMID

  17. Pulse wave velocity is associated with muscle mass decline: Health ABC study.

    Science.gov (United States)

    Abbatecola, Angela Marie; Chiodini, Paolo; Gallo, Ciro; Lakatta, Edward; Sutton-Tyrrell, Kim; Tylavsky, Frances A; Goodpaster, Bret; de Rekeneire, Natalie; Schwartz, Ann V; Paolisso, Giuseppe; Harris, Tamara

    2012-04-01

    Age-related mechanisms that lead to sarcopenia are not entirely understood. Basal leg blood flow declines with aging by augmented sympathetic vasoconstriction and arterial stiffening, thus a dysfunction in blood vessel dynamics may have an independent role on sarcopenia. We determined whether pulse wave velocity (PWV), marker of arterial stiffness, was associated with skeletal muscle decline. Observational cohort study of older adults(70-79 years) living in Pittsburgh, PA, USA or Memphis, TN, USA. Analyses included 2,405 participants. Correlations among muscle parameters including skeletal muscle density and intermuscular adipose tissue using mid-thigh CT scans were assessed. Linear mixed models tested the association between the change in the sarcopenic index (SI) (assessed by dual energy X-ray absorptiometry) over time and baseline PWV independently of multiple confounders. SI was defined: appendicular lean mass/squared height and calculated at every follow-up (n = 6). Baseline PWV was significantly higher in black women compared to white women (930 ± 431 vs. 843 ± 366; p = 0.0001), while there were no significant differences between black and white men (943 ± 402 vs. 911 ± 375; p = 0.1786). Baseline analyses showed an independent negative association between PWV and muscle parameters after adjusting for confounders in both genders. The PWV-by-race interaction was significant in women and analyses are reported separately by race. Prospective mixed models showed that PWV was an independent determinant of the SI in all men (β = -0.1043; p = 0.0065) and in white women (β = -0.1091; p = 0.0192). In analyses examining the effect of arterial stiffness on limb lean mass over time, PWV correlated with lower leg (β = -0.2196; p = 0.0002)and arm mass (β = -0.0985; p = 0.0011) in all men and lower leg mass(β = -0.1608; p = 0.0027)in white women. In older persons, arterial stiffening is associated with skeletal muscle mass decline differently for race and

  18. Intraspecific variation in avian pectoral muscle mass : constraints on maintaining manoeuvrability with increasing body mass

    NARCIS (Netherlands)

    Dietz, Maurine W.; Piersma, Theunis; Hedenstrom, Anders; Brugge, Maarten; Hedenström, Anders; Jackson, Sue

    2007-01-01

    1. Within a single year, long-distance migrants undergo a minimum of four cycles of fuel storage and depletion because their migrations have at least one stopover. Each cycle includes an almost twofold change in body mass (m(b)). Pervasive predation threats beg the question whether escape flight abi

  19. Obesity appears to be associated with altered muscle protein synthetic and breakdown responses to increased nutrient delivery in older men, but not reduced muscle mass or contractile function.

    OpenAIRE

    Andrew J Murton; Marimuthu, Kanagaraj; Mallinson, Joanne E.; Selby, Anna L.; Smith, Kenneth; Rennie, Michael J; Greenhaff, Paul L.

    2015-01-01

    Obesity is increasing, yet despite the necessity to maintain muscle mass and function with age, the effect of obesity on muscle protein turnover in older adults remains unknown. Eleven obese (BMI 31.9 ±1.1) and 15 healthy weight (HW; BMI 23.4 ±0.3) older men (55-75 years old) participated in a study that determined muscle protein synthesis (MPS) and leg protein breakdown (LPB) under post-absorptive (hypoinsulinaemic euglycaemic clamp) and post-prandial (hyperinsulinemic hyperaminoacidaemic eu...

  20. Externally Fed Accretion onto Protostars

    CERN Document Server

    Dalba, Paul A

    2012-01-01

    The asymmetric molecular emission lines from dense cores reveal slow, inward motion in the clouds' outer regions. This motion is present both before and after the formation of a central star. Motivated by these observations, we revisit the classic problem of steady, spherical accretion of gas onto a gravitating point mass, but now include self-gravity of the gas and impose a finite, subsonic velocity as the outer boundary condition. We find that the accretion rate onto the protostar is lower than values obtained for isolated, collapsing clouds, by a factor that is the Mach number of the outer flow. Moreover, the region of infall surrounding the protostar spreads out more slowly, at a speed close to the subsonic, incoming velocity. Our calculation, while highly idealized, provides insight into two longstanding problems -- the surprisingly low accretion luminosities of even the most deeply embedded stellar sources, and the failure so far to detect spatially extended, supersonic infall within their parent dense ...

  1. Eclipse mapping of accretion discs

    CERN Document Server

    Baptista, R

    2000-01-01

    The eclipse mapping method is an inversion technique that makes use of the information contained in eclipse light curves to probe the structure, the spectrum and the time evolution of accretion discs. In this review I present the basics of the method and discuss its different implementations. I summarize the most important results obtained to date and discuss how they have helped to improve our understanding of accretion physics, from testing the theoretical radial brightness temperature distribution and measuring mass accretion rates to showing the evolution of the structure of a dwarf novae disc through its outburst cycle, from isolating the spectrum of a disc wind to revealing the geometry of disc spiral shocks. I end with an outline of the future prospects.

  2. Black hole accretion disc impacts

    CERN Document Server

    Pihajoki, Pauli

    2015-01-01

    We present an analytic model for computing the luminosity and spectral evolution of flares caused by a supermassive black hole impacting the accretion disc of another supermassive black hole. Our model includes photon diffusion, emission from optically thin regions and relativistic corrections to the observed spectrum and time-scales. We test the observability of the impact scenario with a simulated population of quasars hosting supermassive black hole binaries. The results indicate that for a moderate binary mass ratio of 0.3, and impact distances of 100 primary Schwarzschild radii, the accretion disc impacts can be expected to equal or exceed the host quasar in brightness at observed wavelength {\\lambda} = 510 nm up to z = 0.6. We conclude that accretion disc impacts may function as an independent probe for supermassive black hole binaries. We release the code used for computing the model light curves to the community.

  3. Reduced Appendicular Lean Body Mass, Muscle Strength, and Size of Type II Muscle Fibers in Patients with Spondyloarthritis versus Healthy Controls: A Cross-Sectional Study

    Directory of Open Access Journals (Sweden)

    Kristine Røren Nordén

    2016-01-01

    Full Text Available Introduction. The purpose of this study was to investigate body composition, muscle function, and muscle morphology in patients with spondyloarthritis (SpA. Methods. Ten male SpA patients (mean ± SD age 39±4.1 years were compared with ten healthy controls matched for sex, age, body mass index, and self-reported level of physical exercise. Body composition was measured by dual energy X-ray absorptiometry. Musculus quadriceps femoris (QF strength was assessed by maximal isometric contractions prior to test of muscular endurance. Magnetic resonance imaging of QF was used to measure muscle size and calculate specific muscle strength. Percutaneous needle biopsy samples were taken from m. vastus lateralis. Results. SpA patients presented with significantly lower appendicular lean body mass (LBM (p=0.02, but there was no difference in bone mineral density, fat mass, or total LBM. Absolute QF strength was significantly lower in SpA patients (p=0.03 with a parallel trend for specific strength (p=0.08. Biopsy samples from the SpA patients revealed significantly smaller cross-sectional area (CSA of type II muscle fibers (p=0.04, but no difference in CSA type I fibers. Conclusions. Results indicate that the presence of SpA disease is associated with reduced appendicular LBM, muscle strength, and type II fiber CSA.

  4. Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice

    Directory of Open Access Journals (Sweden)

    Yi-Ming Chen

    2016-04-01

    Full Text Available Lactobacillus plantarum (L. plantarum is a well-known probiotic among the ingested-microorganism probiotics (i.e., ingested microorganisms associated with beneficial effects for the host. However, few studies have examined the effects of L. plantarum TWK10 (LP10 supplementation on exercise performance, physical fatigue, and gut microbial profile. Male Institute of Cancer Research (ICR strain mice were divided into three groups (n = 8 per group for oral administration of LP10 for six weeks at 0, 2.05 × 108, or 1.03 × 109 colony-forming units/kg/day, designated the vehicle, LP10-1X and LP10-5X groups, respectively. LP10 significantly decreased final body weight and increased relative muscle weight (%. LP10 supplementation dose-dependently increased grip strength (p < 0.0001 and endurance swimming time (p < 0.001 and decreased levels of serum lactate (p < 0.0001, ammonia (p < 0.0001, creatine kinase (p = 0.0118, and glucose (p = 0.0151 after acute exercise challenge. The number of type I fibers (slow muscle in gastrocnemius muscle significantly increased with LP10 treatment. In addition, serum levels of albumin, blood urea nitrogen, creatinine, and triacylglycerol significantly decreased with LP10 treatment. Long-term supplementation with LP10 may increase muscle mass, enhance energy harvesting, and have health-promotion, performance-improvement, and anti-fatigue effects.

  5. Radiation from optically thin accretion discs

    Energy Technology Data Exchange (ETDEWEB)

    Tylenda, R. (Polska Akademia Nauk, Torun. Pracownia Astrofizyki)

    1981-01-01

    Accretion discs in cataclysmic variables with low rates of mass transfer, M < or approx. 10/sup 16/g s/sup -1/, have outer regions optically thin in continuum. A simple approach that allows one to calculate the radiation spectra from such discs is presented. A great number of disc models has been obtained in order to study the influence of various parameters (accretion rate, outer radius of the disc, inclination angle, mass of the accreting degenerate dwarf, viscosity parameter) of discs on the outgoing continuous spectra, emission lines and the UBV colours.

  6. Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index.

    Science.gov (United States)

    Martin, Lisa; Birdsell, Laura; Macdonald, Neil; Reiman, Tony; Clandinin, M Thomas; McCargar, Linda J; Murphy, Rachel; Ghosh, Sunita; Sawyer, Michael B; Baracos, Vickie E

    2013-04-20

    Emerging evidence suggests muscle depletion predicts survival of patients with cancer. At a cancer center in Alberta, Canada, consecutive patients with cancer (lung or GI; N = 1,473) were assessed at presentation for weight loss history, lumbar skeletal muscle index, and mean muscle attenuation (Hounsfield units) by computed tomography (CT). Univariate and multivariate analyses were conducted. Concordance (c) statistics were used to test predictive accuracy of survival models. Body mass index (BMI) distribution was 17% obese, 35% overweight, 36% normal weight, and 12% underweight. Patients in all BMI categories varied widely in weight loss, muscle index, and muscle attenuation. Thresholds defining associations between these three variables and survival were determined using optimal stratification. High weight loss, low muscle index, and low muscle attenuation were independently prognostic of survival. A survival model containing conventional covariates (cancer diagnosis, stage, age, performance status) gave a c statistic of 0.73 (95% CI, 0.67 to 0.79), whereas a model ignoring conventional variables and including only BMI, weight loss, muscle index, and muscle attenuation gave a c statistic of 0.92 (95% CI, 0.88 to 0.95; P obese, overweight, normal weight, or underweight, in contrast to patients who had none of these features, who survived 28.4 months (95% CI, 24.2 to 32.6; P cancer who are cachexic by the conventional criterion (involuntary weight loss) and by two additional criteria (muscle depletion and low muscle attenuation) share a poor prognosis, regardless of overall body weight.

  7. Obesity Appears to Be Associated With Altered Muscle Protein Synthetic and Breakdown Responses to Increased Nutrient Delivery in Older Men, but Not Reduced Muscle Mass or Contractile Function.

    Science.gov (United States)

    Murton, Andrew J; Marimuthu, Kanagaraj; Mallinson, Joanne E; Selby, Anna L; Smith, Kenneth; Rennie, Michael J; Greenhaff, Paul L

    2015-09-01

    Obesity is increasing, yet despite the necessity of maintaining muscle mass and function with age, the effect of obesity on muscle protein turnover in older adults remains unknown. Eleven obese (BMI 31.9 ± 1.1 kg · m(-2)) and 15 healthy-weight (BMI 23.4 ± 0.3 kg · m(-2)) older men (55-75 years old) participated in a study that determined muscle protein synthesis (MPS) and leg protein breakdown (LPB) under postabsorptive (hypoinsulinemic-euglycemic clamp) and postprandial (hyperinsulinemic hyperaminoacidemic-euglycemic clamp) conditions. Obesity was associated with systemic inflammation, greater leg fat mass, and patterns of mRNA expression consistent with muscle deconditioning, whereas leg lean mass, strength, and work done during maximal exercise were no different. Under postabsorptive conditions, MPS and LPB were equivalent between groups, whereas insulin and amino acid administration increased MPS in only healthy-weight subjects and was associated with lower leg glucose disposal (LGD) (63%) in obese men. Blunting of MPS in the obese men was offset by an apparent decline in LPB, which was absent in healthy-weight subjects. Lower postprandial LGD in obese subjects and blunting of MPS responses to amino acids suggest that obesity in older adults is associated with diminished muscle metabolic quality. This does not, however, appear to be associated with lower leg lean mass or strength.

  8. Fat and muscle mass in different groups of pre-pubertal and pubertal rural children. Cross-cultural comparisons between Sahelian (rural Senegal) and Amazonian (Beni River, Bolivia) children.

    Science.gov (United States)

    Benefice, Eric; Luna Monrroy, Selma J; Lopez Rodriguez, Ronald W; Ndiaye, Gnagna

    2011-07-01

    An increase in fat accretion is essential for triggering the puberty spurt. Hence, nutritional constraints may influence puberty timing. To measure changes in fat and muscle mass in children living in natural environments but with different nutritional exposures. Cross-comparisons of children from rural Senegal and lowland (Amazonian) Bolivia were carried out. Anthropometric measurements of stature, weight, four subcutaneous skin-folds (triceps, biceps, subscapular, supra-iliac) and arm circumference were made. Children were divided into two age groups (5-9.9-year-olds or 'pre pubescents' (n = 381) and 10-15-year-olds or 'pubescents' (n = 692)). Senegalese girls menstruated later than Bolivian girls and Senegalese boys also matured later than Bolivian boys. Bolivian children displayed more fat and muscle before puberty and during puberty than the Senegalese. They also had more fat deposited on the trunk. There were substantial differences in living conditions and nutritional patterns between both locations. In Senegal, nutritional stress is likely to appear early during in utero life and to persist throughout the growth period, including puberty. This leads to a deficit in fat accretion before and during puberty that is associated with a considerable delay in puberty occurrence. In Bolivia, such stress is far less severe. Variability in puberty should be analysed taking into account these differences.

  9. Initial Presentation of Renal Cell Carcinoma as a Metastatic Mass within the Masseter Muscle: A Case Report and Literature Review

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Kyung Eun; Lee, Han Bee; Cho, Woo Ho; Kim, Jae Hyung; Lee, Ji Hae; Kang, Min Jin [Dept. of Radiology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of); Kim, Hyun Jung [Dept. of Pathology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of)

    2012-02-15

    Renal cell carcinoma (RCC) is often concomitant with distant metastasis, and these metastases are the first sign of an otherwise occult primary. Whereas metastasis of RCC to the head and neck has been reported, metastasis to the masseter muscle, which is composed of skeletal muscle, is quite rare. We now report the case of a 66-year-old man who had a past history of pulmonary tuberculosis, with RCC metastasis of a well-defined intensely enhancing hypervascular mass in the masseter muscle as the initial presentation. We present the imaging findings of this case and a literature review about radiologic differential diagnosis of intramasseteric masses.

  10. Interactive effects of growth hormone and exercise on muscle mass in suspended rats

    Science.gov (United States)

    Grindeland, Richard E.; Roy, Roland R.; Edgerton, V. Reggie; Grossman, Elena J.; Mukku, Venkat R.; Jiang, Bian; Pierotti, David J.; Rudolph, Ingrid

    1994-01-01

    Measures to attenuate muscle atrophy in rats in response to simulated microgravity (hindlimb suspension (HS)) have been only partially successful. In the present study, hypophysectomized rats were in HS for 7 days, and the effects of recombinant human growth hormone (GH), exercise (Ex), or GH+Ex on the weights, protein concentrations, and fiber cross-sectional areas (CSAs) of hindlimb muscles were determined. The weights of four extensor muscles, i.e., the soleus (Sol), medial (MG) and lateral (LG) gastrocnemius, and plantaris (Plt), and one adductor, i.e., the adductor longus (AL), were decreased by 10-22% after HS. Fiber CSAs were decreased by 34% in the Sol and by 1 17% in the MG after HS. In contrast, two flexors, i.e., the tibialis anterior (TA) and extensor digitorum longus (EDL), did not atrophy. In HS rats, GH treatment alone maintained the weights of the fast extensors (MG, LG, Plt) and flexors (TA, EDL) at or above those of control rats. This effect was not observed in the slow extensor (Sol) or AL. Exercise had no significant effect on the weight of any muscle in HS rats. A combination of GH and Ex treatments yielded a significant increase in the weights of the fast extensors and in the CSA of both fast and slow fibers of the MG and significantly increased Sol weight and CSA of the slow fibers of the Sol. The AL was not responsive to either GH or Ex treatments. Protein concentrations of the Sol and MG were higher only in the Sol of Ex and GH+Ex rats. These results suggest that while GH treatment or intermittent high intensity exercise alone have a minimal effect in maintaining the mass of unloaded muscle, there is a strong interactive effect of these two treatments.

  11. RUNNING 338 KILOMETRES WITHIN FIVE DAYS HAS NO EFFECT ON BODY MASS AND BODY FAT BUT REDUCES SKELETAL MUSCLE MASS - THE ISARRUN 2006

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    Beat Knechtle

    2007-12-01

    Full Text Available We investigated the change of body composition in ultra- endurance runners during a multi-stage ultra-endurance run, the Isarrun 2006 in Bavaria, Germany, where athletes had to run 338 km within 5 days. Body mass, skin fold thicknesses and circumferences of extremities were measured in 21 well-experienced extreme endurance male runners (mean ± SD, 41.5 ± 6.9 years, 72.6 ± 6.4 kg, 178 ± 5 cm, BMI 23.0 ± 2.0 kg/m2, who finished mainly within the first half of the ranking, in order to calculate skeletal muscle mass and body fat mass to prove changes after the race. Body mass and calculated fat mass did not change significantly (p>0.05, but, calculated skeletal muscle mass decreased significantly (p<0.05 by 0.63 ± 0.79 kg by the end of the race. The most apparent decline (p<0.01 of the calculated skeletal muscle mass was during the first stage, and no changes were observed during the last 4 stages. We conclude, that a multi- stage ultra-endurance run over 338 km within 5 days leads to no changes of body mass or body fat mass, but a statistically significant decrease of skeletal muscle mass of 0.63 ± 0.79 kg by the end of the race in well-trained and well-experienced ultra-endurance runners. The change of skeletal muscle mass has to be evaluated in further studies at ultra-endurance races with suitable methods to detect changes in hydration status and water metabolism

  12. The Orphan Nuclear Receptor Nur77 Is a Determinant of Myofiber Size and Muscle Mass in Mice

    Science.gov (United States)

    Tontonoz, Peter; Cortez-Toledo, Omar; Wroblewski, Kevin; Hong, Cynthia; Lim, Laura; Carranza, Rogelio; Conneely, Orla; Metzger, Daniel

    2015-01-01

    We previously showed that the orphan nuclear receptor Nur77 (Nr4a1) plays an important role in the regulation of glucose homeostasis and oxidative metabolism in skeletal muscle. Here, we show using both gain- and loss-of-function models that Nur77 is also a regulator of muscle growth in mice. Transgenic expression of Nur77 in skeletal muscle in mice led to increases in myofiber size. Conversely, mice with global or muscle-specific deficiency in Nur77 exhibited reduced muscle mass and myofiber size. In contrast to Nur77 deficiency, deletion of the highly related nuclear receptor NOR1 (Nr4a3) had minimal effect on muscle mass and myofiber size. We further show that Nur77 mediates its effects on muscle size by orchestrating transcriptional programs that favor muscle growth, including the induction of insulin-like growth factor 1 (IGF1), as well as concomitant downregulation of growth-inhibitory genes, including myostatin, Fbxo32 (MAFbx), and Trim63 (MuRF1). Nur77-mediated increase in IGF1 led to activation of the Akt-mTOR-S6K cascade and the inhibition of FoxO3a activity. The dependence of Nur77 on IGF1 was recapitulated in primary myoblasts, establishing this as a cell-autonomous effect. Collectively, our findings identify Nur77 as a novel regulator of myofiber size and a potential transcriptional link between cellular metabolism and muscle growth. PMID:25605333

  13. Brown dwarf accretion: Nonconventional star formation over very long timescales

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    Ćirković Milan M.

    2005-01-01

    Full Text Available We investigate the process of accretion of interstellar gas by the Galactic population of brown dwarfs over very long timescales typical for physical eschatology. In particular, we use the classical Hoyle-Lyttleton-Bondi accretion model to investigate the rate at which brown dwarfs collect enough additional mass to become red dwarfs, accretion-induced changes in the mass function of the low- mass objects, and the corresponding accretion heating of brown dwarfs. In addition, we show how we can make the definition of the final mass function for stellar objects more precise.

  14. Accretion and Outflow Activity in Brown Dwarfs

    CERN Document Server

    Riaz, B

    2013-01-01

    An investigation of the magnetospheric accretion and outflow signatures in sub-stellar objects is a natural extension of similar studies conducted on classical T Tauri stars (CTTS), and helps understand if brown dwarfs (BDs) follow the same formation mechanism as stars. Over the past decade, evidence for accretion in very low-mass stars (VLMs) and BDs has been accumulated using various techniques, which indicates that the overall accretion characteristics are continuous across the sub-stellar boundary. Outflow activity in VLMs and BDs has been confirmed based on spectro-astrometry of forbidden emission lines observed in the optical, and in millimetre continuum images of CO J=2-1 emission. This review summarizes the past and current state of observational work on accretion and outflow activity in VLMs and BDs, particularly with the advent of new instruments such as VLT/X-Shooter which has allowed the study of several accretion and outflow indicators over a wider wavelength range.

  15. Spiral shocks and accretion in discs

    Energy Technology Data Exchange (ETDEWEB)

    Spruit, H.C.; Matsuda, T.; Inoue, M.; Sawada, K.

    1987-12-01

    Recent numerical and analytical results on disc-like accretion with shock waves as the only dissipation mechanism are compared. The global properties of the process are similar to those of the viscous (..cap alpha..) disc model, but precise values of the effective ..cap alpha.. value as a function of the accretion rate can be calculated. At low values of the ratio of specific heats (..gamma.. < 1.45) accretion is possible without radiative losses. Such adiabatic accretion can occur in practice at high accretion rates on to low mass objects and may be important in the formation of planets. Following previous authors, it is pointed out that non-axisymmetric perturbations in the outer parts of a disc increase in amplitude as they propagate in and cause spiral shocks more easily in a disc than perturbations originating in the inner parts.

  16. Bondi-Hoyle-Lyttleton Accretion onto a Protoplanetary Disk

    CERN Document Server

    Moeckel, Nickolas

    2009-01-01

    Young stellar systems orbiting in the potential of their birth cluster can accrete from the dense molecular interstellar medium during the period between the star's birth and the dispersal of the cluster's gas. Over this time, which may span several Myr, the amount of material accreted can rival the amount in the initial protoplanetary disk; the potential importance of this `tail-end' accretion for planet formation was recently highlighted by Throop & Bally (2008). While accretion onto a point mass is successfully modeled by the classical Bondi-Hoyle-Lyttleton solutions, the more complicated case of accretion onto a star-disk system defies analytic solution. In this paper we investigate via direct hydrodynamic simulations the accretion of dense interstellar material onto a star with an associated gaseous protoplanetary disk. We discuss the changes to the structure of the accretion flow caused by the disk, and vice versa. We find that immersion in a dense accretion flow can redistribute disk material such ...

  17. Baseline muscle mass is a poor predictor of functional overload-induced gain in the mouse model

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    Audrius Kilikevicius

    2016-11-01

    Full Text Available Genetic background contributes substantially to individual variability in muscle mass. Muscle hypertrophy in response to resistance training can also vary extensively. However, it is less clear if muscle mass at baseline is predictive of the hypertrophic response.The aim of this study was to examine the effect of genetic background on variability in muscle mass at baseline and in the adaptive response of the mouse fast- and slow-twitch muscles to overload. Males of eight laboratory mouse strains: C57BL/6J (B6, n=17, BALB/cByJ (n=7, DBA/2J (D2, n=12, B6.A-(rs3676616-D10Utsw1/Kjn (B6.A, n=9, C57BL/6J-Chr10A/J/NaJ (B6.A10, n=8, BEH+/+ (n=11, BEH (n=12 and DUHi (n=12, were studied. Compensatory growth of soleus and plantaris muscles was triggered by a 4-week overload induced by synergist unilateral ablation. Muscle weight in the control leg (baseline varied from 5.2±07 mg soleus and 11.4±1.3 mg plantaris in D2 mice to 18.0±1.7 mg soleus in DUHi and 43.7±2.6 mg plantaris in BEH (p<0.001 for both muscles. In addition, soleus in the B6.A10 strain was ~40% larger (p<0.001 compared to the B6. Functional overload increased muscle weight, however, the extent of gain was strain-dependent for both soleus (p<0.01 and plantaris (p<0.02 even after accounting for the baseline differences. For the soleus muscle, the BEH strain emerged as the least responsive, with a 1.3-fold increase, compared to a 1.7-fold gain in the most responsive D2 strain, and there was no difference in the gain between the B6.A10 and B6 strains. The BEH strain appeared the least responsive in the gain of plantaris as well, 1.3-fold, compared to ~1.5-fold gain in the remaining strains. We conclude that variation in muscle mass at baseline is not a reliable predictor of that in the overload-induced gain. This suggests that a different set of genes influence variability in muscle mass acquired in the process of normal development, growth and maintenance, and in the process of adaptive

  18. Protein Considerations for Optimising Skeletal Muscle Mass in Healthy Young and Older Adults

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    Oliver C. Witard

    2016-03-01

    Full Text Available Skeletal muscle is critical for human health. Protein feeding, alongside resistance exercise, is a potent stimulus for muscle protein synthesis (MPS and is a key factor that regulates skeletal muscle mass (SMM. The main purpose of this narrative review was to evaluate the latest evidence for optimising the amino acid or protein source, dose, timing, pattern and macronutrient coingestion for increasing or preserving SMM in healthy young and healthy older adults. We used a systematic search strategy of PubMed and Web of Science to retrieve all articles related to this review objective. In summary, our findings support the notion that protein guidelines for increasing or preserving SMM are more complex than simply recommending a total daily amount of protein. Instead, multifactorial interactions between protein source, dose, timing, pattern and macronutrient coingestion, alongside exercise, influence the stimulation of MPS, and thus should be considered in the context of protein recommendations for regulating SMM. To conclude, on the basis of currently available scientific literature, protein recommendations for optimising SMM should be tailored to the population or context of interest, with consideration given to age and resting/post resistance exercise conditions.

  19. Label-free profiling of skeletal muscle using high-definition mass spectrometry

    Science.gov (United States)

    Burniston, Jatin G.; Connolly, Joanne; Kainulainen, Heikki; Britton, Steven L.; Koch, Lauren G.

    2014-01-01

    We report automated and time efficient (2 h per sample) profiling of muscle using ultra-performance liquid chromatography (LC) coupled directly with high-definition mass spectrometry (HDMSE). Soluble proteins extracted from rat gastrocnemius (n=10) were digested with trypsin and analysed in duplicate using a 90 min RPLC gradient. Protein identification and label-free quantitation were performed from HDMSE spectra analysed using TransOmics Informatics for Proteomics software. In total 1,514 proteins were identified. Of these, 811 had at least 3 unique peptides and were subsequently used to assess the dynamic range and precision of LC-HDMSE label-free profiling. Proteins analysed by LC-HDMSE encompass the entire complement of glycolytic, beta-oxidation and tricarboxylic acid enzymes. In addition, numerous components of the electron transport chain and protein kinases involved in skeletal muscle regulation were detected. The dynamic range of protein abundances spanned 4 orders of magnitude. The correlation between technical replicates of the 10 biological samples was R2 = 0.9961 ± 0.0036 (95 % CI = 0.9940 – 0.9992) and the technical coefficient of variation averaged 7.3 ± 6.7 % (95 % CI = 6.87 – 7.79 %). This represents the most sophisticated label-free profiling of skeletal muscle to date. PMID:25065561

  20. Accretion by the Galaxy

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    Binney J.

    2012-02-01

    Full Text Available Cosmology requires at least half of the baryons in the Universe to be in the intergalactic medium, much of which is believed to form hot coronae around galaxies. Star-forming galaxies must be accreting from their coronae. Hi observations of external galaxies show that they have Hi halos associated with star formation. These halos are naturally modelled as ensembles of clouds driven up by supernova bubbles. These models can fit the data successfully only if clouds exchange mass and momentum with the corona. As a cloud orbits, it is ablated and forms a turbulent wake where cold high-metallicity gas mixes with hot coronal gas causing the prompt cooling of the latter. As a consequence the total mass of Hi increases. This model has recently been used to model the Leiden-Argentina-Bonn survey of Galactic Hi. The values of the model’s parameters that are required to model NGC 891, NGC 2403 and our Galaxy show a remarkable degree of consistency, despite the very different natures of the two external galaxies and the dramatic difference in the nature of the data for our Galaxy and the external galaxies. The parameter values are also consistent with hydrodynamical simulations of the ablation of individual clouds. The model predicts that a galaxy that loses its cool-gas disc for instance through a major merger cannot reform it from its corona; it can return to steady star formation only if it can capture a large body of cool gas, for example by accreting a gas-rich dwarf. Thus the model explains how major mergers can make galaxies “red and dead.”

  1. Reduced bone mass and muscle strength in male 5α-reductase type 1 inactivated mice.

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    Sara H Windahl

    Full Text Available Androgens are important regulators of bone mass but the relative importance of testosterone (T versus dihydrotestosterone (DHT for the activation of the androgen receptor (AR in bone is unknown. 5α-reductase is responsible for the irreversible conversion of T to the more potent AR activator DHT. There are two well established isoenzymes of 5α-reductase (type 1 and type 2, encoded by separate genes (Srd5a1 and Srd5a2. 5α-reductase type 2 is predominantly expressed in male reproductive tissues whereas 5α-reductase type 1 is highly expressed in liver and moderately expressed in several other tissues including bone. The aim of the present study was to investigate the role of 5α-reductase type 1 for bone mass using Srd5a1⁻/⁻ mice. Four-month-old male Srd5a1⁻/⁻ mice had reduced trabecular bone mineral density (-36%, p<0.05 and cortical bone mineral content (-15%, p<0.05 but unchanged serum androgen levels compared with wild type (WT mice. The cortical bone dimensions were reduced in the male Srd5a1⁻/⁻ mice as a result of a reduced cortical periosteal circumference compared with WT mice. T treatment increased the cortical periosteal circumference (p<0.05 in orchidectomized WT mice but not in orchidectomized Srd5a1⁻/⁻ mice. Male Srd5a1⁻/⁻ mice demonstrated a reduced forelimb muscle grip strength compared with WT mice (p<0.05. Female Srd5a1⁻/⁻ mice had slightly increased cortical bone mass associated with elevated circulating levels of androgens. In conclusion, 5α-reductase type 1 inactivated male mice have reduced bone mass and forelimb muscle grip strength and we propose that these effects are due to lack of 5α-reductase type 1 expression in bone and muscle. In contrast, the increased cortical bone mass in female Srd5a1⁻/⁻ mice, is an indirect effect mediated by elevated circulating androgen levels.

  2. Foundations of Black Hole Accretion Disk Theory.

    Science.gov (United States)

    Abramowicz, Marek A; Fragile, P Chris

    2013-01-01

    This review covers the main aspects of black hole accretion disk theory. We begin with the view that one of the main goals of the theory is to better understand the nature of black holes themselves. In this light we discuss how accretion disks might reveal some of the unique signatures of strong gravity: the event horizon, the innermost stable circular orbit, and the ergosphere. We then review, from a first-principles perspective, the physical processes at play in accretion disks. This leads us to the four primary accretion disk models that we review: Polish doughnuts (thick disks), Shakura-Sunyaev (thin) disks, slim disks, and advection-dominated accretion flows (ADAFs). After presenting the models we discuss issues of stability, oscillations, and jets. Following our review of the analytic work, we take a parallel approach in reviewing numerical studies of black hole accretion disks. We finish with a few select applications that highlight particular astrophysical applications: measurements of black hole mass and spin, black hole vs. neutron star accretion disks, black hole accretion disk spectral states, and quasi-periodic oscillations (QPOs).

  3. Association between muscle mass and disability in performing instrumental activities of daily living (IADL) in community-dwelling elderly in Japan.

    Science.gov (United States)

    Tanimoto, Yoshimi; Watanabe, Misuzu; Sun, Wei; Hirota, Chika; Sugiura, Yumiko; Kono, Rei; Saito, Masahisa; Kono, Koichi

    2012-01-01

    This study describes the association between low muscle mass and disability in performing IADL in elderly, community-dwelling Japanese subjects. Subjects were 1268 elderly, community-dwelling Japanese aged 65 years or older. Low muscle mass was defined by appendicular muscle mass index (AMI, weight [kg]/height [m(2)]), measured by bioelectrical impedance analysis (BIA). We classified "middle" AMI as a value 1-2 standard deviation (SD) below the young normal mean of AMI and "low" as more than 2 SD below the young normal mean. Examination of IADL was performed using the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC) questionnaire. In this study, 17.2% and 26.2% of elderly men and women, respectively, were classified as having low muscle mass. There was a significant association with age and the change from normal to middle to low muscle mass in both men and women. The prevalence of IADL disability also increased significantly as muscle mass decreased. After adjustment for age and BMI, low muscle mass was significantly associated with IADL disability in men and women. Furthermore, middle muscle mass was significantly associated with IADL disability in women. This study revealed that low muscle mass, defined as a value 2 SD below the mean of young adults, had a significant association with IADL disability in elderly Japanese. Interventions to prevent age-related losses in muscle mass may be an effective strategy to prevent IADL disability among the elderly.

  4. Jet Luminosity from Neutrino-Dominated Accretion Flows in GRBs

    CERN Document Server

    Kawanaka, Norita

    2013-01-01

    A hyperaccretion disk around a stellar-mass black hole is a plausible model for the central engine that powers gamma-ray bursts (GRBs). We estimate the luminosity of a jet driven by magnetohydrodynamic processes such as the Blandford-Znajek (BZ) mechanism as a function of mass accretion rate, the black hole mass, and other accretion parameters. We show that the jet is most efficient when the accretion flow is cooled via optically-thin neutrino emission, and that its luminosity is much larger than the energy deposition rate through neutrino annihilation provided that the black hole is spinning rapidly enough. Also, we find a significant jump in the jet luminosity at the transition mass accretion rate between the advection dominated accretion flow (ADAF) regime and the neutrino-dominated accretion flow (NDAF) regime. This may cause the large variability observed in the prompt emission of GRBs.

  5. Masses of inositol phosphates in resting and tetanically stimulated vertebrate skeletal muscles.

    Science.gov (United States)

    Mayr, G W; Thieleczek, R

    1991-12-15

    The masses of inositol phosphates have been determined in isolated skeletal muscles from Xenopus laevis (sartorius, tibialis anterior and iliofibularis) and rat (gastrocnemius and soleus) which were quick-frozen in the resting state and at different stages of an isometric (Xenopus) or isotonic (rat) tetanus. The isomeric spectrum of inositol phosphates detected was similar to that in other tissues and cell types. The total sarcoplasmic concentrations of the isomers Ins-(1,4,5,6)P4/Ins(3,4,5,6)P4 (0.2-0.9 microM), Ins(1,3,4,6)P4 (not detectable), Ins(1,3,4,5,6)P5 (about 1 microM) and InsP6 (3.2-4.6 microM) were lower than in other cell types. Variations in these concentrations were due to the muscle type rather than to the donor species. The putative second messenger Ins(1,4,5)P3, as well as its dephosphorylation product Ins(1,4)P2, were present at surprisingly high total myoplasmic resting concentrations, ranging from 1.2 to 2.5 microM and 3.5 to 6.9 microM respectively. Upon tetanic stimulation these two inositol phosphates in particular exhibited significantly increased total sarcoplasmic concentrations, up to 4.2 microM and 11.3 microM respectively, with a time scale of seconds. From the initial rate of increase in the total sarcoplasmic concentrations of Ins(1,4,5)P3 and its rapidly formed metabolic products, a minimal phosphoinositidase C (PIC) activity in tetanically activated Xenopus skeletal muscle of about 1.7-2.6 microM/s can be estimated. This PIC activity observed in vivo seems to be far too low to account for a functional role for Ins(1,4,5)P3 as a chemical transmitter in the fast excitation-contraction coupling (ECC) process in skeletal muscle. The presence of Ins(1,3,4,5)P4 in all muscle types is indicative of a Ca(2+)-activated Ins(1,4,5)P3 3-kinase activity. The rapid transient increases in Ins(1,3,4)P3 and Ins(1,3)P2 in isometrically contracting Xenopus muscles suggest that corresponding Ins(1,3,4,5)P4 phosphatases are operating in skeletal muscle

  6. Poynting Jets from Accretion Disks

    CERN Document Server

    Lovelace, R V E; Ustyugova, G V; Romanova, M M; Colgate, S A

    2002-01-01

    The powerful narrow jets observed to emanate from many compact accreting objects may arise from the twisting of a magnetic field threading a differentially rotating accretion disk which acts to magnetically extract angular momentum and energy from the disk. Two main regimes have been discussed, {\\it hydromagnetic outflows}, which have a significant mass flux and have energy and angular momentum carried by both the matter and the electromagnetic field and, Poynting outflows, where the mass flux is negligible and energy and angular momentum are carried predominantly by the electromagnetic field. Here we consider a Keplerian disk initially threaded by a dipole-like magnetic field and we present solutions of the force-free Grad-Shafranov equation for the coronal plasma. We find solutions with Poynting jets where there is a continuous outflow of energy and toroidal magnetic flux from the disk into the external space. This behavior contradicts the commonly accepted ``theorem'' of Solar plasma physics that the motio...

  7. Accretion disks in luminous young stellar objects

    CERN Document Server

    Beltran, M T

    2015-01-01

    An observational review is provided of the properties of accretion disks around young stars. It concerns the primordial disks of intermediate- and high-mass young stellar objects in embedded and optically revealed phases. The properties were derived from spatially resolved observations and therefore predominantly obtained with interferometric means, either in the radio/(sub)millimeter or in the optical/infrared wavelength regions. We make summaries and comparisons of the physical properties, kinematics, and dynamics of these circumstellar structures and delineate trends where possible. Amongst others, we report on a quadratic trend of mass accretion rates with mass from T Tauri stars to the highest mass young stellar objects and on the systematic difference in mass infall and accretion rates.

  8. Disks, accretion and outflows of brown dwarfs

    CERN Document Server

    Joergens, V; Liu, Y; Pascucci, I; Whelan, E; Alcala, J; Biazzo, K; Costigan, G; Gully-Santiago, M; Henning, Th; Natta, A; Rigliaco, E; Rodriguez-Ledesma, V; Sicilia-Aguilar, A; Tottle, J; Wolf, S

    2012-01-01

    Characterization of the properties of young brown dwarfs are important to constraining the formation of objects at the extreme low-mass end of the IMF. While young brown dwarfs share many properties with solar-mass T Tauri stars, differences may be used as tests of how the physics of accretion/outflow and disk chemistry/dissipation depend on the mass of the central object. This article summarizes the presentations and discussions during the splinter session on 'Disks, accretion and outflows of brown dwarfs' held at the CoolStars17 conference in Barcelona in June 2012. Recent results in the field of brown dwarf disks and outflows include the determination of brown dwarf disk masses and geometries based on Herschel far-IR photometry (70-160 um), accretion properties based on X-Shooter spectra, and new outflow detections in the very low-mass regime.

  9. Dynamics of warped accretion discs

    OpenAIRE

    Tremaine, Scott; Davis, Shane W.

    2013-01-01

    Accretion discs are present around both stellar-mass black holes in X-ray binaries and supermassive black holes in active galactic nuclei. A wide variety of circumstantial evidence implies that many of these discs are warped. The standard Bardeen--Petterson model attributes the shape of the warp to the competition between Lense--Thirring torque from the central black hole and viscous angular-momentum transport within the disc. We show that this description is incomplete, and that torques from...

  10. Relation between body mass index percentile and muscle strength and endurance

    Directory of Open Access Journals (Sweden)

    Noha Abdel Kader Abdel Kader Hasan

    2016-10-01

    Conclusion: The study shows that the BMI of children had a positive correlation with the muscle strength of quadriceps, triceps, and abdominal muscles while a negative correlation with the endurance time of these muscles.

  11. Perturbation growth in accreting filaments

    Science.gov (United States)

    Clarke, S. D.; Whitworth, A. P.; Hubber, D. A.

    2016-05-01

    We use smoothed particle hydrodynamic simulations to investigate the growth of perturbations in infinitely long filaments as they form and grow by accretion. The growth of these perturbations leads to filament fragmentation and the formation of cores. Most previous work on this subject has been confined to the growth and fragmentation of equilibrium filaments and has found that there exists a preferential fragmentation length-scale which is roughly four times the filament's diameter. Our results show a more complicated dispersion relation with a series of peaks linking perturbation wavelength and growth rate. These are due to gravo-acoustic oscillations along the longitudinal axis during the sub-critical phase of growth. The positions of the peaks in growth rate have a strong dependence on both the mass accretion rate onto the filament and the temperature of the gas. When seeded with a multiwavelength density power spectrum, there exists a clear preferred core separation equal to the largest peak in the dispersion relation. Our results allow one to estimate a minimum age for a filament which is breaking up into regularly spaced fragments, as well as an average accretion rate. We apply the model to observations of filaments in Taurus by Tafalla & Hacar and find accretion rates consistent with those estimated by Palmeirim et al.

  12. Outflow from Hot Accretion Flows

    CERN Document Server

    Yuan, Feng; Wu, Maochun

    2012-01-01

    Numerical simulations of hot accretion flows have shown that the mass accretion rate decreases with decreasing radius. Two models have been proposed to explain this result. In the adiabatic inflow-outflow solution (ADIOS), it is thought to be due to the loss of gas in outflows. In the convection-dominated accretion flow (CDAF) model, it is explained as because that the gas is locked in convective eddies. In this paper we use hydrodynamical (HD) and magnetohydrodynamical (MHD) simulations to investigate which one is physical. We calculate and compare various properties of inflow (gas with an inward velocity) and outflow (gas with an outward velocity). Systematic and significant differences are found. For example, for HD flows, the temperature of outflow is higher than inflow; while for MHD flows, the specific angular momentum of outflow is much higher than inflow. We have also analyzed the convective stability of MHD accretion flow and found that they are stable. These results suggest that systematic inward an...

  13. Phantom Accretion onto the Schwarzschild de-Sitter Black Hole

    Institute of Scientific and Technical Information of China (English)

    M Sharif; G Abbas

    2011-01-01

    We deal with phantom energy accretion onto the Schwarzschild de-Sitter black hole. The energy flux conservation, relativistic Bernoulli equation and mass Bux conservation equation are formulated to discuss the phantom accretion. We discuss the conditions for critical accretion. It is found that the mass of the black hole decreases due to phantom accretion. There exist two critical points which lie in the exterior of horizons (black hole and cosmological horizons). The results for the phantom energy accretion onto the Schwarzschild black hole can be recovered by taking A → 0.%@@ We deal with phantom energy accretion onto the Schwarzschild de-Sitter black hole.The energy flux conserva-tion,relativistic Bernoulli equation and mass flux conservation equation are formulated to discuss the phantom accretion.We discuss the conditions for critical accretion.It is found that the mass of the black hole decreases due to phantom accretion.There exist two critical points which lie in the exterior of horizons(black hole and cosmological horizons).The results for the phantom energy accretion onto the Schwarzschild black hole can be recovered by taking ∧→0.

  14. Associations between lower extremity muscle mass and metabolic parameters related to obesity in Japanese obese patients with type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Hidetaka Hamasaki

    2015-05-01

    Full Text Available Background. Age-related loss of muscle mass (sarcopenia increases the incidence of obesity in the elderly by reducing physical activity. This sarcopenic obesity may become self-perpetuating, increasing the risks for metabolic syndrome, disability, and mortality. We investigated the associations of two sarcopenic indices, the ratio of lower extremity muscle mass to body weight (L/W ratio and the ratio of lower extremity muscle mass to upper extremity muscle mass (L/U ratio, with metabolic parameters related to obesity in patients with type 2 diabetes and obesity.Methods. Of 148 inpatients with type 2 diabetes treated between October 2013 and April 2014, we recruited 26 with obesity but no physical disability. Daily physical activity was measured by a triaxial accelerometer during a period of hospitalization, and which was also evaluated by our previously reported non-exercise activity thermogenesis questionnaire. We measured body composition by bioelectrical impedance and investigated the correlations of L/W and L/U ratios with body weight, body mass index (BMI, waist circumference (WC, waist-to-hip ratio (WHR, visceral fat area, subcutaneous fat area, serum lipid profile, and daily physical activity.Results. The L/W ratio was significantly and negatively correlated with BMI, WC, WHR, body fat mass, body fat percentage, subcutaneous fat area, and serum free fatty acid concentration, was positively correlated with daily physical activity: the locomotive non-exercise activity thermogenesis score, but was not correlated with visceral fat area. The L/U ratio was significantly and positively correlated with serum high-density lipoprotein cholesterol.Conclusions. High L/W and L/U ratios, indicative of relatively preserved lower extremity muscle mass, were predictive of improved metabolic parameters related to obesity. Preserved muscle fitness in obesity, especially of the lower extremities, may prevent sarcopenic obesity and lower associated risks for

  15. Gas dynamics for accretion disk simulations

    Science.gov (United States)

    Whitehurst, R.

    1994-01-01

    The behavior of accretion disks can largely be understood in terms of the basic physical processes of mass, energy, and momentum conservation. Despite this, detailed modeling of these systems using modern computational techniques is challenging and controversial. Disturbing differences exist between methods used widely in astrophysics, namely Eulerian finite-difference techniques and particle codes such as SPH. Therefore neither technique is fully satisfactory for accretion disk simulations. This paper describes a new fully Lagrangian method designed to resolve these difficulties.

  16. The Effect of a 12-Week Omega-3 Supplementation on Body Composition, Muscle Strength and Physical Performance in Elderly Individuals with Decreased Muscle Mass

    Directory of Open Access Journals (Sweden)

    Roma Krzymińska-Siemaszko

    2015-08-01

    Full Text Available The aim of the study was to assess the effect of a polyunsaturated omega-3 fatty acids (PUFA supplementation on the parameters of body composition, muscle strength and physical performance in elderly people with decreased muscle mass (DMM. Fifty three elderly people with an ALM index (the ratio of appendicular lean mass to squared height either below (−2SD: low muscle mass-LMM or between (−1SD and −2SD: the risk of LMM-rLMM the ALM index for the young Polish reference population were randomly assigned to PUFA-treated groups (LMM-PUFA, rLMM-PUFA or control groups (LMM-control, rLMM-control. PUFA-treated groups received capsules containing 1.3 g of PUFA and 10 mg of vitamin E, while the control groups received 11 mg of vitamin E daily for 12 weeks. Body composition (BIA analysis, muscle strength (hand grip measured with dynamometer and physical performance (Timed Up and Go test-TUG were assessed before and after supplementation. No statistically significant differences were observed either in muscle mass or in the hand grip and TUG in any group. The post-pre difference (mean ± SD in ALM index was as follows (kg/m2: LMM-PUFA: 0.00 ± 0.30, rLMM-PUFA: 0.00 ± 0.22, LMM-control: 0.03 ± 0.36, rLMM-control: –0.03 ± 0.20. In our study, a 12 week supplementation of PUFA did not affect the evaluated parameters in elderly individuals with DMM.

  17. Ageing influence in the evolution of strength and muscle mass in women with fibromyalgia: the al-Ándalus project.

    Science.gov (United States)

    Latorre-Román, Pedro Ángel; Segura-Jiménez, Víctor; Aparicio, Virginia A; Santos E Campos, María Aparecida; García-Pinillos, Felipe; Herrador-Colmenero, Manuel; Álvarez-Gallardo, Inmaculada C; Delgado-Fernández, Manuel

    2015-07-01

    Fibromyalgia is associated with physical disabilities in daily activities. Moreover, patients with fibromyalgia present similar levels of functional capacity and physical condition than elderly people. The aim of this study was to analyse the evolution of strength and muscle mass in women with fibromyalgia along ageing. A total sample of 492 fibromyalgia patients and 279 healthy control women were included in the study. Participants in each group were further divided into four age subgroups: subgroup 1: 30-39 years old, subgroup 2: 40-49 years old, subgroup 3: 50-59 years old and subgroup 4: 60-69 years old. Standardized field-based fitness tests were used to assess muscle strength (30-s chair stand, handgrip strength and arm curl tests). Fibromyalgia patients did not show impairment on muscle mass along ageing, without values of skeletal muscle mass index below 6.76 kg/m(2) in any group. However, in all variables of muscle strength, the fibromyalgia group showed less strength than the healthy group (p fibromyalgia group (p fibromyalgia showed a reduction in muscle strength along ageing process, with significantly lower scores than healthy women for each age group, representing a risk of dynapenia.

  18. Interindividual differences in leg muscle mass and pyruvate kinase activity correlate with interindividual differences in jumping performance of Hyla multilineata.

    Science.gov (United States)

    James, Rob S; Wilson, Robbie S; de Carvalho, José E; Kohlsdorf, Tiana; Gomes, Fernando R; Navas, Carlos A

    2005-01-01

    Frog jumping is an excellent model system for examining the structural basis of interindividual variation in burst locomotor performance. Some possible factors that affect jump performance, such as total body size, hindlimb length, muscle mass, and muscle mechanical and biochemical properties, were analysed at the interindividual (intraspecies) level in the tree frog Hyla multilineata. The aim of this study was to determine which of these physiological and anatomical variables both vary between individuals and are correlated with interindividual variation in jump performance. The model produced via stepwise linear regression analysis of absolute data suggested that 62% of the interindividual variation in maximum jump distance could be explained by a combination of interindividual variation in absolute plantaris muscle mass, total hindlimb muscle mass (excluding plantaris muscle), and pyruvate kinase activity. When body length effects were removed, multiple regression indicated that the same independent variables explained 43% of the residual interindividual variation in jump distance. This suggests that individuals with relatively large jumping muscles and high pyruvate kinase activity for their body size achieved comparatively large maximal jump distances for their body size.

  19. Moving mesh cosmology: tracing cosmological gas accretion

    CERN Document Server

    Nelson, Dylan; Genel, Shy; Sijacki, Debora; Keres, Dusan; Springel, Volker; Hernquist, Lars; 10.1093/mnras/sts595

    2013-01-01

    We investigate the nature of gas accretion onto haloes and galaxies at z=2 using cosmological hydrodynamic simulations run with the moving mesh code AREPO. Implementing a Monte Carlo tracer particle scheme to determine the origin and thermodynamic history of accreting gas, we make quantitative comparisons to an otherwise identical simulation run with the smoothed particle hydrodynamics (SPH) code GADGET-3. Contrasting these two numerical approaches, we find significant physical differences in the thermodynamic history of accreted gas in haloes above 10^10.5 solar masses. In agreement with previous work, GADGET simulations show a cold fraction near unity for galaxies forming in massive haloes, implying that only a small percentage of accreted gas heats to an appreciable fraction of the virial temperature during accretion. The same galaxies in AREPO show a much lower cold fraction, <20% in haloes above 10^11 solar masses. This results from a hot gas accretion rate which, at this same halo mass, is an order o...

  20. Accretion onto Black Holes from Large Scales Regulated by Radiative Feedback. III. Enhanced Luminosity of Intermediate Mass Black Holes Moving at Supersonic Speeds

    CERN Document Server

    Park, KwangHo

    2012-01-01

    In this paper, the third of a series, we study the growth rate and luminosity of black holes (BHs) in motion with respect to their surrounding medium by running a large set of 2D axis-symmetric radiation-hydrodynamic simulations. Contrary to the case without radiation feedback, we find that the accretion rate increases with increasing BH velocity v reaching a maximum value at v = 2c_s ~ 50 km/s, where c_s is the sound speed inside the "cometary-shaped" HII region around the BH, before decreasing as v^{-3}. The increase of the accretion rate with v is produced by the formation of a D-type (density) ionization front (I-front) preceded by a standing bow-shock that reduces the downstream gas velocity to transonic values. Since the I-front is beyond the classical Bondi radius for the hot ionized gas, the accretion flow in the BH frame of reference is similar to the stationary case. Interestingly, there is a range of densities and velocities in which the dense shell downstream of the bow-shock is unstable; its cent...

  1. Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage.

    Science.gov (United States)

    Dubois, Vanessa; Simitsidellis, Ioannis; Laurent, Michaël R; Jardi, Ferran; Saunders, Philippa T K; Vanderschueren, Dirk; Claessens, Frank

    2015-12-01

    Androgens increase skeletal muscle mass, but their clinical use is hampered by a lack of tissue selectivity and subsequent side effects. Selective androgen receptor modulators elicit muscle-anabolic effects while only sparingly affecting reproductive tissues. The selective androgen receptor modulator, GTx-024 (enobosarm), is being investigated for cancer cachexia, sarcopenia, and muscle wasting diseases. Here we investigate the role of muscle androgen receptor (AR) in the anabolic effect of GTx-024. In mice lacking AR in the satellite cell lineage (satARKO), the weight of the androgen-sensitive levator ani muscle was lower but was decreased further upon orchidectomy. GTx-024 was as effective as DHT in restoring levator ani weights to sham levels. Expression of the muscle-specific, androgen-responsive genes S-adenosylmethionine decarboxylase and myostatin was decreased by orchidectomy and restored by GTx-024 and DHT in control mice, whereas the expression was low and unaffected by androgen status in satARKO. In contrast, insulin-like growth factor 1Ea expression was not different between satARKO and control muscle, decreased upon castration, and was restored by DHT and GTx-024 in both genotypes. These data indicate that GTx-024 does not selectively modulate AR in the satellite cell lineage and that cells outside this lineage remain androgen responsive in satARKO muscle. Indeed, residual AR-positive cells were present in satARKO muscle, coexpressing the fibroblast-lineage marker vimentin. AR positive, muscle-resident fibroblasts could therefore be involved in the indirect effects of androgens on muscle. In conclusion, both DHT and GTx-024 target AR pathways in the satellite cell lineage, but cells outside this lineage also contribute to the anabolic effects of androgens.

  2. Imaging mass spectrometry reveals fiber-specific distribution of acetylcarnitine and contraction-induced carnitine dynamics in rat skeletal muscles.

    Science.gov (United States)

    Furuichi, Yasuro; Goto-Inoue, Naoko; Manabe, Yasuko; Setou, Mitsutoshi; Masuda, Kazumi; Fujii, Nobuharu L

    2014-10-01

    Carnitine is well recognized as a key regulator of long-chain fatty acyl group translocation into the mitochondria. In addition, carnitine, as acetylcarnitine, acts as an acceptor of excess acetyl-CoA, a potent inhibitor of pyruvate dehydrogenase. Here, we provide a new methodology for accurate quantification of acetylcarnitine content and determination of its localization in skeletal muscles. We used matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) to visualize acetylcarnitine distribution in rat skeletal muscles. MALDI-IMS and immunohistochemistry of serial cross-sections showed that acetylcarnitine was enriched in the slow-type muscle fibers. The concentration of ATP was lower in muscle regions with abundant acetylcarnitine, suggesting a relationship between acetylcarnitine and metabolic activity. Using our novel method, we detected an increase in acetylcarnitine content after muscle contraction. Importantly, this increase was not detected using traditional biochemical assays of homogenized muscles. We also demonstrated that acetylation of carnitine during muscle contraction was concomitant with glycogen depletion. Our methodology would be useful for the quantification of acetylcarnitine and its contraction-induced kinetics in skeletal muscles.

  3. Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes

    DEFF Research Database (Denmark)

    Pedersen, Maria; Bruunsgaard, Helle; Hendel, Helle W

    2003-01-01

    mass. Twenty young controls, (20-35 yr), 20 healthy elderly subjects (65-80 yr) and 16 elderly patients with type 2 diabetes (65-80 yr) were included in a cross sectional study. Plasma levels of TNF-alpha and IL-6 were measured after an overnight fast. Dual-energy X-ray absorptiometry and total body......The purpose of the current study was to test the hypothesis that an altered fat distribution in elderly healthy subjects and in patients with type-2 diabetes contributes to high circulating levels of interleukin (IL)-6 and tumor necrotic factor (TNF)-alpha, which secondly is related to lower muscle...... potassium counting measured truncal fat, appendicular skeletal muscle mass (ASM) and body cell mass (BCM), respectively. TNF-alpha, IL-6 and the relative truncal fat mass were higher in elderly compared with young controls. ASM was lower in diabetic men than in young controls and BCM was lower in elderly...

  4. Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes

    DEFF Research Database (Denmark)

    Pedersen, Maria; Bruunsgaard, Helle; Weis, Nina

    2003-01-01

    mass. Twenty young controls, (20-35 yr), 20 healthy elderly subjects (65-80 yr) and 16 elderly patients with type 2 diabetes (65-80 yr) were included in a cross sectional study. Plasma levels of TNF-alpha and IL-6 were measured after an overnight fast. Dual-energy X-ray absorptiometry and total body......The purpose of the current study was to test the hypothesis that an altered fat distribution in elderly healthy subjects and in patients with type-2 diabetes contributes to high circulating levels of interleukin (IL)-6 and tumor necrotic factor (TNF)-alpha, which secondly is related to lower muscle...... potassium counting measured truncal fat, appendicular skeletal muscle mass (ASM) and body cell mass (BCM), respectively. TNF-alpha, IL-6 and the relative truncal fat mass were higher in elderly compared with young controls. ASM was lower in diabetic men than in young controls and BCM was lower in elderly...

  5. Dynamics of core accretion

    Science.gov (United States)

    Nelson, Andrew F.; Ruffert, Maximilian

    2013-02-01

    We perform three-dimensional hydrodynamic simulations of gas flowing around a planetary core of mass Mpl = 10M⊕ embedded in a near Keplerian background flow, using a modified shearing box approximation. We assume an ideal gas behaviour following an equation of state with a fixed ratio of the specific heats, γ = 1.42, consistent with the conditions of a moderate-temperature background disc with solar composition. No radiative heating or cooling is included in the models. We employ a nested grid hydrodynamic code implementing the `Piecewise Parabolic Method' with as many as six fixed nested grids, providing spatial resolution on the finest grid comparable to the present-day diameters of Neptune and Uranus. We find that a strongly dynamically active flow develops such that no static envelope can form. The activity is not sensitive to plausible variations in the rotation curve of the underlying disc. It is sensitive to the thermodynamic treatment of the gas, as modelled by prescribed equations of state (either `locally isothermal' or `locally isentropic') and the temperature of the background disc material. The activity is also sensitive to the shape and depth of the core's gravitational potential, through its mass and gravitational softening coefficient. Each of these factors influences the magnitude and character of hydrodynamic feedback of the small-scale flow on the background, and we conclude that accurate modelling of such feedback is critical to a complete understanding of the core accretion process. The varying flow pattern gives rise to large, irregular eruptions of matter from the region around the core which return matter to the background flow: mass in the envelope at one time may not be found in the envelope at any later time. No net mass accretion into the envelope is observed over the course of the simulation and none is expected, due to our neglect of cooling. Except in cases of very rapid cooling however, as defined by locally isothermal or

  6. Is increase in bone mineral content caused by increase in skeletal muscle mass/strength in adult patients with GH-treated GH deficiency?

    DEFF Research Database (Denmark)

    Klefter, Oliver; Feldt-Rasmussen, Ulla

    2009-01-01

    performed a systematic literature analysis, including 51 clinical trials published between 1996 and 2008, which had studied the development in muscle mass, muscle strength, BMD, and/or BMC in GH-treated adult GHD patients. RESULTS: GH therapy had an anabolic effect on skeletal muscle. The largest increase......OBJECTIVE: Adult patients with GH deficiency (GHD) are characterized by a reduced muscle mass, but also reduced bone mineral density (BMD) and content (BMC), which have been ascribed to GHD per se. The aim of this study was to investigate if changes in BMD/BMC in adult GHD patients could be due...... to a muscle modulating effect, and if treatment with GH would primarily increase muscle mass and strength with a secondary increase in BMD/BMC, thus supporting the present physiological concept that mass and strength of bones are mainly determined by dynamic loads from the skeletal muscles. METHOD: We...

  7. Determination of fenbendazole and oxfendazole in liver and muscle using liquid chromatography-mass spectrometry.

    Science.gov (United States)

    Blanchflower, W J; Cannavan, A; Kennedy, D G

    1994-06-01

    A method has been developed for the determination of the anthelmintics fenbendazole and oxfendazole in liver and muscle samples using liquid chromatography-thermospray mass spectrometry (LC-MS). The samples were homogenized with water, sonicated with methanol and centrifuged. The supernatants were washed with light petroleum and extracted with diethyl ether-ethyl acetate. The extracts were evaporated to dryness, dissolved in mobile phase and injected into the LC-MS system. Fenbendazole and oxfendazole were measured separately using two different mobile phases. Single-ion monitoring of the positive ion at m/z 300 was used for fenbendazole and of m/z 316 for oxfendazole. The detection limits for the assay were 0.05 microgram g-1 for fenbendazole and 0.1 microgram g-1 for oxfendazole. The mean recoveries were 91% for fenbendazole and 86% for oxfendazole. The assay has been used for statutory testing purposes and for measuring the levels of fenbendazole and oxfendazole in liver and muscle from sheep after dosing with a commercial anthelmintic containing fenbendazole.

  8. Pulsed Accretion in a Variable Protostar

    CERN Document Server

    Muzerolle, James; Flaherty, Kevin; Balog, Zoltan; Gutermuth, Robert

    2013-01-01

    Periodic increases in luminosity arising from variable accretion rates have been predicted for some close pre-main sequence binary stars as they grow from circumbinary disks. The phenomenon is known as "pulsed accretion" and can affect the orbital evolution and mass distribution of young binaries, as well as the potential for planet formation in the circumbinary environment. Accretion variability is a common feature of young stars, with a large range of amplitudes and timescales as measured from multi-epoch observations at optical and infrared wavelengths. Periodic variations consistent with pulsed accretion have been seen in only a few young binaries via optical accretion tracers, albeit intermittently with accretion luminosity variations ranging from 0-50 percent from orbit to orbit. Here we report on a young protostar (age ~10^5 yr) that exhibits periodic variability in which the infrared luminosity increases by a factor of 10 in roughly one week every 25.34 days. We attribute this to pulsed accretion asso...

  9. Lithium synthesis in microquasar accretion.

    Science.gov (United States)

    Iocco, Fabio; Pato, Miguel

    2012-07-13

    We study the synthesis of lithium isotopes in the hot tori formed around stellar mass black holes by accretion of the companion star. We find that sizable amounts of both stable isotopes 6Li and 7Li can be produced, the exact figures varying with the characteristics of the torus and reaching as much as 10(-2) M⊙ for each isotope. This mass output is enough to contaminate the entire Galaxy at a level comparable with the original, pregalactic amount of lithium and to overcome other sources such as cosmic-ray spallation or stellar nucleosynthesis.

  10. Protostellar accretion traced with chemistry

    DEFF Research Database (Denmark)

    Frimann, Søren; Jørgensen, Jes Kristian; Dunham, Michael M.

    2017-01-01

    . Our aim is to characterise protostellar accretion histories towards individual sources by utilising sublimation and freeze-out chemistry of CO. Methods. A sample of 24 embedded protostars are observed with the Submillimeter Array (SMA) in context of the large program "Mass Assembly of Stellar Systems...... and their Evolution with the SMA" (MASSES). The size of the C18O-emitting region, where CO has sublimated into the gas-phase, is measured towards each source and compared to the expected size of the region given the current luminosity. The SMA observations also include 1.3 mm continuum data, which are used...

  11. Thermally Driven Winds from Radiatively Inefficient Accretion Flows

    CERN Document Server

    Kawabata, Ryoji

    2009-01-01

    Radiatively inefficient accretion flows (RIAFs) are common feature of low-luminosity accretion flows, including quiescent states of X-ray binaries and low-lunimosity active galactic nuclei. Thermally driven winds are expected from such hot accretion flows. By assuming that the flow has self-similarity structure in the radial direction, we solve the vertical structure of the wind and accretion flows simultaneously and evaluate the mass loss rates by wind. We find that the ratio of the outflow rate to the accretion rate is approximately unity for a viscosity parameter, alpha lesssim 0.1, despite some uncertainties in the angular momentum and temperature distributions. That is, the accretion rate in the RIAFs is roughly proportional to the radius. Moreover, we elucidate the effect of cooling by wind on the underneath accretion flow, finding that this effect could be important for calculating energy spectrum of the RIAF. Observational implications are briefly discussed in the context of Sgr A*.

  12. Probing thermonuclear burning on accreting neutron stars

    NARCIS (Netherlands)

    Keek, L.

    2008-01-01

    Neutron stars are the most compact stars that can be directly observed, which makes them ideal laboratories to study physics at extreme densities. Neutron stars in low-mass X-ray binaries accrete hydrogen and helium from a lower-mass companion star through Roche lobe overflow. This matter undergoes

  13. The Role of Muscle Mass, Muscle Quality, and Body Composition in Risk for the Metabolic Syndrome and Functional Decline in Older Adults: Topical Collection on Nutrition, Obesity, and Diabetes

    NARCIS (Netherlands)

    R.T. Mankowski (Robert T.); S.D. Anton (Stephen D.); M. Aubertin-Leheudre (Mylene)

    2015-01-01

    textabstractAbstract Age-related body composition changes include both loss of muscle mass (sarcopenia) and increase in fat mass, which jointly contribute to a decline in metabolic functions. Muscle quality is positively related to functional capacity and a lower risk for the development of the meta

  14. The Role of Muscle Mass, Muscle Quality, and Body Composition in Risk for the Metabolic Syndrome and Functional Decline in Older Adults: Topical Collection on Nutrition, Obesity, and Diabetes

    NARCIS (Netherlands)

    R.T. Mankowski (Robert T.); S.D. Anton (Stephen D.); M. Aubertin-Leheudre (Mylene)

    2015-01-01

    textabstractAbstract Age-related body composition changes include both loss of muscle mass (sarcopenia) and increase in fat mass, which jointly contribute to a decline in metabolic functions. Muscle quality is positively related to functional capacity and a lower risk for the development of the

  15. Three Dimensional MHD Simulation of Circumbinary Accretion Disks -2. Net Accretion Rate

    CERN Document Server

    Shi, Ji-Ming

    2015-01-01

    When an accretion disk surrounds a binary rotating in the same sense, the binary exerts strong torques on the gas. Analytic work in the 1D approximation indicated that these torques sharply diminish or even eliminate accretion from the disk onto the binary. However, recent 2D and 3D simulational work has shown at most modest diminution. We present new MHD simulations demonstrating that for binaries with mass ratios of 1 and 0.1 there is essentially no difference between the accretion rate at large radius in the disk and the accretion rate onto the binary. To resolve the discrepancy with earlier analytic estimates, we identify the small subset of gas trajectories traveling from the inner edge of the disk to the binary and show how the full accretion rate is concentrated onto them.

  16. n-3 Fatty acids preserve muscle mass and insulin sensitivity in a rat model of energy restriction.

    Science.gov (United States)

    Galmiche, Guillaume; Huneau, Jean-François; Mathé, Véronique; Mourot, Jacques; Simon, Noémie; Le Guillou, Céline; Hermier, Dominique

    2016-10-01

    In obese subjects, the loss of fat mass during energy restriction is often accompanied by a loss of muscle mass. The hypothesis that n-3 PUFA, which modulate protein homoeostasis via effects on insulin sensitivity, could contribute to maintain muscle mass during energy restriction was tested in rats fed a high-fat diet (4 weeks) rich in 18 : 1 n-9 (oleic acid, OLE-R), 18 : 3 n-3 (α-linolenic acid, ALA-R) or n-3 long-chain (LC-R) fatty acid and then energy restricted (8 weeks). A control group (OLE-ad libitum (AL)) was maintained with AL diet throughout the study. Rats were killed 10 min after an i.v. insulin injection. All energy-restricted rats lost weight and fat mass, but only the OLE-R group showed a significant muscle loss. The Gastrocnemius muscle was enriched with ALA in the ALA-R group and with LC-PUFA in the ALA-R and LC-R groups. The proteolytic ubiquitin-proteasome system was differentially affected by energy restriction, with MAFbx and muscle ring finger-1 mRNA levels being decreased in the LC-R group (-30 and -20 %, respectively). RAC-α serine/threonine-protein kinase and insulin receptor substrate 1 phosphorylation levels increased in the LC-R group (+70 %), together with insulin receptor mRNA (+50 %). The ALA-R group showed the same overall activation pattern as the LC-R group, although to a lesser extent. In conclusion, dietary n-3 PUFA prevent the loss of muscle mass associated with energy restriction, probably by an improvement in the insulin-signalling pathway activation, in relation to enrichment of plasma membranes in n-3 LC-PUFA.

  17. Perturbation growth in accreting filaments

    CERN Document Server

    Clarke, Seamus D; Hubber, David A

    2016-01-01

    We use smoothed particle hydrodynamic simulations to investigate the growth of perturbations in infinitely long, initially sub-critical but accreting filaments. The growth of these perturbations leads to filament fragmentation and the formation of cores. Most previous work on this subject has been confined to the growth and fragmentation of equilibrium filaments and has found that there exists a preferential fragmentation length scale which is roughly 4 times the filament's diameter. Our results show a more complicated dispersion relation with a series of peaks linking perturbation wavelength and growth rate. These are due to gravo-acoustic oscillations along the longitudinal axis during the sub-critical phase of growth. The positions of the peaks in growth rate have a strong dependence on both the mass accretion rate onto the filament and the temperature of the gas. When seeded with a multi-wavelength density power spectrum there exists a clear preferred core separation equal to the largest peak in the dispe...

  18. Higher Daily Physical Activities Continue to Preserve Muscle Strength After Mid-Life, But Not Muscle Mass After Age of 75.

    Science.gov (United States)

    Hwang, An-Chun; Zhan, Yu-Rui; Lee, Wei-Ju; Peng, Li-Ning; Chen, Liang-Yu; Lin, Ming-Hsien; Liu, Li-Kuo; Chen, Liang-Kung

    2016-05-01

    The objective of this study is to explore the impact of aging and daily physical activities (PA) on muscle mass and muscle strength among community-dwelling people in Taiwan.The design is a cross-sectional study. Setting is a population-based community study.One thousand eight hundred thirty-nine community-dwelling people aged 50 years and older in Taiwan participated in the study.Measurements include demographic characteristics, Charlson Comorbidity Index (CCI) for multimorbidity, mini-nutritional assessment (MNA) for nutritional evaluation, functional autonomy measurement system (SMAF) for functional capacity, Chinese version mini mental state examination (MMSE), 5-item Taiwan Geriatric Depression Scale (TGDS-5), Chinese version of International Physical Activity Questionnaire (IPAQ), height-adjusted skeletal muscle index (SMI) by dual-energy X-ray absorptiometry, handgrip strength, timed 6-m walking test for usual gait speed. Laboratory measurements include testosterone, sex-hormone binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEA-S), insulin-like growth factor-1 (IGF-1), high-sensitivity C-reactive protein (hsCRP), 25-OH vitamin D, and insulin resistance.After adjusted for age, the lowest PA tertile was associated with multimorbidity, poorer functional capacity and nutritional status, more depressive symptoms, lower SMI and lower handgrip strength, and lower free androgen index (FAI) in men. The negative association between PA and low SMI was more significant among subjects aged younger than 65 and the association decreased with older age. For subjects aged younger than 65, moderate daily PA (Q2) group had lower risk of low SMI compared with Q1 participants (OR: 0.62, 95% CI = 0.39-0.98, P = 0.040). For muscle strength, higher daily PA was associated with lower risk of low handgrip strength after age of 65 and the effect was dose-dependent. The effect was attenuated by potential confounders during age 65 to 74, while after age 75, the

  19. Coronal Neutrino Emission in Hypercritical Accretion Flows

    CERN Document Server

    Kawabata, R; Kawanaka, N

    2007-01-01

    Hypercritical accretion flows onto stellar mass black holes (BHs) are commonly considered as a promising model of central engines of gamma-ray bursts (GRBs). In this model a certain fraction of gravitational binding energy of accreting matter is deposited to the energy of relativistic jets via neutrino annihilation and/or magnetic fields. However, some recent studies have indicated that the energy deposition rate by neutrino annihilation is somewhat smaller than that needed to power a GRB. To overcome this difficulty, Ramirez-Ruiz & Socrates (2005) proposed that high energy neutrinos from hot corona above the accretion disk might enhance the efficiency of energy deposition. We elucidate the disk corona model in the context of hypercritical accretion flows. From the energy balance in the disk and the corona, we can calculate the disk and coronal temperature, Td and Tc, and neutrino spectra, taking into account the neutrino cooling processes by neutrino-electron scatterings and neutrino pair productions. Th...

  20. Electrically Stimulated Antagonist Muscle Contraction Increased Muscle Mass and Bone Mineral Density of One Astronaut - Initial Verification on the International Space Station.

    Directory of Open Access Journals (Sweden)

    Naoto Shiba

    Full Text Available Musculoskeletal atrophy is one of the major problems of extended periods of exposure to weightlessness such as on the International Space Station (ISS. We developed the Hybrid Training System (HTS to maintain an astronaut's musculoskeletal system using an electrically stimulated antagonist to resist the volitional contraction of the agonist instead of gravity. The present study assessed the system's orbital operation capability and utility, as well as its preventative effect on an astronaut's musculoskeletal atrophy.HTS was attached to the non-dominant arm of an astronaut staying on the ISS, and his dominant arm without HTS was established as the control (CTR. 10 sets of 10 reciprocal elbow curls were one training session, and 12 total sessions of training (3 times per week for 4 weeks were performed. Pre and post flight ground based evaluations were performed by Biodex (muscle performance, MRI (muscle volume, and DXA (BMD, lean [muscle] mass, fat mass. Pre and post training inflight evaluations were performed by a hand held dynamometer (muscle force and a measuring tape (upper arm circumference.The experiment was completed on schedule, and HTS functioned well without problems. Isokinetic elbow extension torque (Nm changed -19.4% in HTS, and -21.7% in CTR. Isokinetic elbow flexion torque changed -23.7% in HTS, and there was no change in CTR. Total Work (Joule of elbow extension changed -8.3% in HTS, and +0.3% in CTR. For elbow flexion it changed -23.3% in HTS and -32.6% in CTR. Average Power (Watts of elbow extension changed +22.1% in HTS and -8.0% in CTR. For elbow flexion it changed -6.5% in HTS and -4.8% in CTR. Triceps muscle volume according to MRI changed +11.7% and that of biceps was +2.1% using HTS, however -0.1% and -0.4% respectively for CTR. BMD changed +4.6% in the HTS arm and -1.2% for CTR. Lean (muscle mass of the arm changed only +10.6% in HTS. Fat mass changed -12.6% in HTS and -6.4% in CTR.These results showed the orbital

  1. Electrically Stimulated Antagonist Muscle Contraction Increased Muscle Mass and Bone Mineral Density of One Astronaut - Initial Verification on the International Space Station.

    Science.gov (United States)

    Shiba, Naoto; Matsuse, Hiroo; Takano, Yoshio; Yoshimitsu, Kazuhiro; Omoto, Masayuki; Hashida, Ryuki; Tagawa, Yoshihiko; Inada, Tomohisa; Yamada, Shin; Ohshima, Hiroshi

    2015-01-01

    Musculoskeletal atrophy is one of the major problems of extended periods of exposure to weightlessness such as on the International Space Station (ISS). We developed the Hybrid Training System (HTS) to maintain an astronaut's musculoskeletal system using an electrically stimulated antagonist to resist the volitional contraction of the agonist instead of gravity. The present study assessed the system's orbital operation capability and utility, as well as its preventative effect on an astronaut's musculoskeletal atrophy. HTS was attached to the non-dominant arm of an astronaut staying on the ISS, and his dominant arm without HTS was established as the control (CTR). 10 sets of 10 reciprocal elbow curls were one training session, and 12 total sessions of training (3 times per week for 4 weeks) were performed. Pre and post flight ground based evaluations were performed by Biodex (muscle performance), MRI (muscle volume), and DXA (BMD, lean [muscle] mass, fat mass). Pre and post training inflight evaluations were performed by a hand held dynamometer (muscle force) and a measuring tape (upper arm circumference). The experiment was completed on schedule, and HTS functioned well without problems. Isokinetic elbow extension torque (Nm) changed -19.4% in HTS, and -21.7% in CTR. Isokinetic elbow flexion torque changed -23.7% in HTS, and there was no change in CTR. Total Work (Joule) of elbow extension changed -8.3% in HTS, and +0.3% in CTR. For elbow flexion it changed -23.3% in HTS and -32.6% in CTR. Average Power (Watts) of elbow extension changed +22.1% in HTS and -8.0% in CTR. For elbow flexion it changed -6.5% in HTS and -4.8% in CTR. Triceps muscle volume according to MRI changed +11.7% and that of biceps was +2.1% using HTS, however -0.1% and -0.4% respectively for CTR. BMD changed +4.6% in the HTS arm and -1.2% for CTR. Lean (muscle) mass of the arm changed only +10.6% in HTS. Fat mass changed -12.6% in HTS and -6.4% in CTR. These results showed the orbital operation

  2. Supermassive blackholes without super Eddington accretion

    Science.gov (United States)

    Christian, Damian Joseph; Kim, Matt I.; Garofalo, David; D'Avanzo, Jaclyn; Torres, John

    2017-08-01

    We explore the X-ray luminosity function at high redshift for active galactic nuclei using an albeit simplified model for mass build-up using a combination of mergers and mass accretion in the gap paradigm (Garofalo et al. 2010). Using a retrograde-dominated configuration we find an interesting low probability channel for the growth of one billion solar mass black holes within hundreds of millions of years of the big bang without appealing to super Eddington accretion (Kim et al. 2016). This result is made more compelling by the connection between this channel and an end product involving active galaxies with FRI radio morphology but weaker jet powers in mildly sub-Eddington accretion regimes. We will discuss our connection between the unexplained paucity of a given family of AGNs and the rapid growth of supermassive black holes, two heretofore seemingly unrelated aspects of the physics of AGNs that will help further understand their properties and evolution.

  3. Global Models for Embedded, Accreting Protostellar Disks

    CERN Document Server

    Kratter, Kaitlin M; Krumholz, Mark R

    2007-01-01

    Most analytic work to date on protostellar disks has focused on disks in isolation from their environments. However, observations are now beginning to probe the earliest, most embedded phases of star formation, during which disks are rapidly accreting from their parent cores and cannot be modeled in isolation. We present a simple, one-zone model of protostellar accretion disks with high mass infall rates. Our model combines a self-consistent calculation of disk temperatures with an approximate treatment of angular momentum transport via several mechanisms. We use this model to survey the properties of protostellar disks across a wide range of stellar masses and evolutionary times, and make predictions for disks' masses, sizes, spiral structure, and fragmentation that will be directly testable by future large-scale surveys of deeply embedded disks. We define a dimensionless accretion-rotation parameter which, in conjunction with the disk's temperature, controls the disk evolution. We track the dominant mode of...

  4. ASYMMETRIC ACCRETION FLOWS WITHIN A COMMON ENVELOPE

    Energy Technology Data Exchange (ETDEWEB)

    MacLeod, Morgan; Ramirez-Ruiz, Enrico [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States)

    2015-04-10

    This paper examines flows in the immediate vicinity of stars and compact objects dynamically inspiralling within a common envelope (CE). Flow in the vicinity of the embedded object is gravitationally focused, leading to drag and potentially to gas accretion. This process has been studied numerically and analytically in the context of Hoyle–Lyttleton accretion (HLA). Yet, within a CE, accretion structures may span a large fraction of the envelope radius, and in so doing sweep across a substantial radial gradient of density. We quantify these gradients using detailed stellar evolution models for a range of CE encounters. We provide estimates of typical scales in CE encounters that involve main sequence stars, white dwarfs, neutron stars, and black holes with giant-branch companions of a wide range of masses. We apply these typical scales to hydrodynamic simulations of three-dimensional HLA with an upstream density gradient. This density gradient breaks the symmetry that defines HLA flow, and imposes an angular momentum barrier to accretion. Material that is focused into the vicinity of the embedded object thus may not be able to accrete. As a result, accretion rates drop dramatically, by one to two orders of magnitude, while drag rates are only mildly affected. We provide fitting formulae to the numerically derived rates of drag and accretion as a function of the density gradient. The reduced ratio of accretion to drag suggests that objects that can efficiently gain mass during CE evolution, such as black holes and neutron stars, may grow less than implied by the HLA formalism.

  5. Total-body creatine pool size and skeletal muscle mass determination by creatine-(methyl-d3) dilution in rats

    National Research Council Canada - National Science Library

    Stephen A. Stimpson; Scott M. Turner; Lisa G. Clifton; James C. Poole; Hussein A. Mohammed; Todd W. Shearer; Greg M. Waitt; Laura L. Hagerty; Katja S. Remlinger; Marc K. Hellerstein; William J. Evans

    2012-01-01

    .... We tested in rats the hypothesis that the enrichment of creatinine-(methyl-d3) (D3-creatinine) in urine after a defined oral tracer dose of D3-creatine can be used to determine creatine pool size and skeletal muscle mass...

  6. Basic Training of Student’s Outdoor Club Increases Muscle Mass after Five Weeks of Exercise in Males

    Directory of Open Access Journals (Sweden)

    Novie Salsabila

    2015-03-01

    Full Text Available Background: Aerobic and anaerobic exercises, may lead to increase muscle mass. The aim of this study was to determine the change in muscle mass during basic training of students’ outdoor club. Methods: This was an observational analytic study to college students who joined basic training of students’ outdoor club for 19 weeks. Subjects consisted of 17 male and 15 female students, measured five times consecutively by using Body Fat/Hydration monitor scale, with Bioelectrical Impedance Analysis principle. Data collection was performed five times, from February to July 2012 in Bandung. Statistical analysis was processed using Analysis of Variance (ANOVA. Results: The result in males showed the mean 43.35±3.15 on the initial measurement. The muscle mass further increased significantly after five, ten, fifteen, and nineteen weeks of exercise (43.73±3.18 (p0.05; 38.08±1.67 (p>0.05 ; 38.23±1.52 (p>0.05 ; 38.61±1.52 (p<0.05 vs 37.77±2.00 respectively. Conclusion: Basic training of student’s outdoor club increases muscle mass significantly after five weeks of exercise in males, but not in females

  7. Revealing a Cool Accretion Disk in the Ultraluminous X-ray Source M81 X-9 (Holmberg IX X-1): Evidence for an Intermediate Mass Black Hole

    CERN Document Server

    Miller, J M; Miller, M C

    2003-01-01

    We report the results of an analysis of two XMM-Newton/EPIC-pn spectra of the bright ultraluminous X-ray source M81 X-9 (Holmberg IX X-1), obtained in snapshot observations. Soft thermal emission is clearly revealed in spectra dominated by hard power-law components. Depending on the model used, M81 X-9 was observed at a luminosity of L_X = 1.0-1.6 E+40 erg/s (0.3-10.0 keV). The variability previously observed in this source signals that it is an accreting source which likely harbors a black hole. Remarkably, accretion disk models for the soft thermal emission yield very low inner disk temperatures (kT = 0.17-0.29 keV, including 90 per cent confidence errors and variations between observations and disk models), and improve the fit statistic over any single-component continuum model at the 6 sigma level of confidence. This represents much stronger evidence for a cool disk than prior evidence which combined spectra from different observatories, and the strongest evidence of a cool disk in an ultraluminous X-ray ...

  8. [METHODS OF EVALUATION OF MUSCLE MASS: A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIALS].

    Science.gov (United States)

    Moreira, Osvaldo Costa; de Oliveira, Cláudia Eliza Patrocínio; Candia-Luján, Ramón; Romero-Pérez, Ena Monserrat; de Paz Fernandez, José Antonio

    2015-09-01

    Introducción: en los últimos años las investigaciones sobre la masa muscular han cobrado popularidad por su relación con la salud. Así, la medición precisa de la masa muscular puede tener aplicación clínica, ya que puede interferir en el diagnóstico y prescripción del tratamiento medicamentoso o no medicamentoso. Objetivo: realizar una revisión sistemática de los métodos más utilizados para la evaluación de la masa muscular en ensayos controlados aleatorios, con sus ventajas y desventajas. Método: se llevó a cabo una búsqueda en las bases de datos Pubmed, Web of Science y Scopus, con las palabras muscle mass, measurement, assessment y evaluation, combinadas de esta manera: “muscle mass” AND (measurement OR assessment OR evaluation). Resultados: 23 estudios fueron recuperados y analizados, todos ellos en inglés. El 69,56% utilizaron solamente un método para la cuantificación de la masa muscular; el 69,57% utilizaron la doble absorciometría de rayos X (DXA); en el 45,46% el tipo de medida utilizado fue la masa corporal total libre de grasa; y el 51,61% eligieron el cuerpo total como sitio de medida. Conclusiones: en los ensayos controlados aleatorios analizados la mayor parte utilizó apenas un método de evaluación, siendo la DXA el método más empleado, la masa corporal total libre de grasa el tipo de medida más utilizado y el cuerpo total el sitio de medida más común.

  9. Assessment of respiratory muscle strength in children according to the classification of body mass index

    Directory of Open Access Journals (Sweden)

    George Jung da Rosa

    2014-06-01

    Full Text Available OBJECTIVE: To assess and compare the respiratory muscle strength among eutrophic, overweight and obese school children, as well as to identify anthropometric and respiratory variables related to the results.METHODS: Cross-sectional survey with healthy schoolchildren aged 7-9 years old, divided into three groups: Normal weight, Overweight and Obese. The International Study of Asthma and Allergies in Childhood (ISAAC questionnaire was applied. The body mass index (BMI was evaluated, as well as the forced expiratory volume in one second (FEV1 with a portable digital device. The maximal inspiratory and expiratory pressures (MIP and MEP were measured by a digital manometer. Comparisons between the groups were made by Kruskal-Wallis test. Spearman's correlation coefficient was used to analyze the correlations among the variables.RESULTS: MIP of eutrophic school children was higher than MIP found in overweight (p=0.043 and obese (p=0.013 children. MIP was correlated with BMI percentile and weight classification (r=-0.214 and r=-0.256 and MEP was correlated with height (r=0.328. Both pressures showed strong correlation with each other in all analyses (r≥0.773, and less correlation with FEV1 (MIP - r=0.362 and MEP - r=0.494. FEV1 correlated with MEP in all groups (r: 0.429 - 0.569 and with MIP in Obese Group (r=0.565. Age was correlated with FEV1 (r=0.578, MIP (r=0.281 and MEP (r=0.328.CONCLUSIONS: Overweight and obese children showed lower MIP values, compared to eutrophic ones. The findings point to the influence of anthropometric variables on respiratory muscle strength in children.

  10. Resistance exercise and the mechanisms of muscle mass regulation in humans: acute effects on muscle protein turnover and the gaps in our understanding of chronic resistance exercise training adaptation.

    Science.gov (United States)

    Murton, A J; Greenhaff, P L

    2013-10-01

    Increasing muscle mass is important when attempting to maximize sports performance and achieve physique augmentation. However, the preservation of muscle mass is essential to maintaining mobility and quality of life with aging, and also impacts on our capacity to recover from illness. Nevertheless, our understanding of the processes that regulate muscle mass in humans during resistance exercise training, chronic disuse and rehabilitation training following atrophy remains very unclear. Here, we report on some of the recent developments in the study of those processes thought to be responsible for governing human muscle protein turnover in response to intense physical activity. Specifically, the effects of acute and chronic resistance exercise in healthy volunteers and also in response to rehabilitation resistance exercise training following muscle atrophy will be discussed, with discrepancies and gaps in our understanding highlighted. In particular, ubiquitin-proteasome mediated muscle proteolysis (Muscle Atrophy F-box/Atrogin-1 and Muscle RING Finger 1), translation initiation of muscle protein synthesis (mammalian target of rapamycin signaling), and satellite cell mediated myogenesis are highlighted as pathways of special relevance to muscle protein metabolism in response to acute resistance exercise. Furthermore, research focused on quantifying signaling and molecular events that modulate muscle protein synthesis and protein degradation under conditions of chronic resistance training is highlighted as being urgently needed to improve knowledge gaps. These studies need to include multiple time-point measurements over the course of any training intervention and must include dynamic measurements of muscle protein synthesis and degradation and sensitive measures of muscle mass. This article is part of a Directed Issue entitled Molecular basis of muscle wasting.

  11. Accretion disc flows around FU Orionis stars

    Science.gov (United States)

    Clarke, C. J.; Lin, D. N. C.; Papaloizou, J. C. B.

    1989-01-01

    The accretion disk model of FU Orionis systems in outburst is investigated by examining the time-dependent behavior of a disk around a low-mass protostar that accretes at 0.00001-0.0001 solar masses/yr. It is found that the disk may be stabilized against the thermal ionization instability by the effect of advective heat transport and that it may therefore exist in the quasi-steady-state observed in post-outburst FU Orionis systems. The disk models are used to discuss the cosmochemical consequences of possible FU Ori events during the evolution of the primordial solar nebula.

  12. Validity of anthropometric measurements to assess body composition, including muscle mass, in 3-year-old children from the SKOT cohort

    DEFF Research Database (Denmark)

    Jensen, Signe Marie; Mølgaard, Christian; Ejlerskov, Katrine Tschentscher

    2015-01-01

    expressed as percentage of total body mass, this proportion was 51% and 66%, respectively; and for muscle mass as percentage of lean mass it was 34%. All the best reduced multivariate models included weight, skinfold and gender except the model estimating the proportion of muscle mass in lean body mass......, which included only mid-upper arm circumference and subscapular skinfold. The power of height in the weight-to-height ratio to determine fat mass proportion was 1.71 with a 95% confidence interval (0.83-2.60) including the value of 2 used in body mass index (BMI). Limitations of anthropometry to assess...

  13. Impact of Weight Loss on Physical Function with Changes in Strength, Muscle Mass, and Muscle Fat Infiltration in Overweight to Moderately Obese Older Adults: A Randomized Clinical Trial

    Directory of Open Access Journals (Sweden)

    Adam J. Santanasto

    2011-01-01

    Full Text Available Purpose. Evaluate the effects of weight loss on muscle mass and area, muscle fat infiltration, strength, and their association with physical function. Methods. Thirty-six overweight to moderately obese, sedentary older adults were randomized into either a physical activity plus weight loss (PA+WL or physical activity plus successful aging health education (PA+SA program. Measurements included body composition by dual-energy X-ray absorptiometry, computerized tomography, knee extensor strength, and short physical performance battery (SPPB. Results. At 6 months, PA+WL lost greater thigh fat and muscle area compared to PA+SA. PA+WL lost 12.4% strength; PA+SA lost 1.0%. Muscle fat infiltration decreased significantly in PA+WL and PA+SA. Thigh fat area decreased 6-fold in comparison to lean area in PA+WL. Change in total SPPB score was strongly inversely correlated with change in fat but not with change in lean or strength. Conclusion. Weight loss resulted in additional improvements in function over exercise alone, primarily due to loss of body fat.

  14. Value of measuring muscle performance to assess changes in lean mass with testosterone and growth hormone supplementation.

    Science.gov (United States)

    Schroeder, E Todd; He, Jiaxiu; Yarasheski, Kevin E; Binder, Ellen F; Castaneda-Sceppa, Carmen; Bhasin, Shalender; Dieli-Conwright, Christina M; Kawakubo, Miwa; Roubenoff, Ronenn; Azen, Stanley P; Sattler, Fred R

    2012-03-01

    We hypothesized that treatment with testosterone (T) and recombinant human growth hormone (rhGH) would increase lean mass (LM) and muscle strength proportionally and an in a linear manner over 16 weeks. This was a multicenter, randomized, controlled, double-masked investigation of T and rhGH supplementation in older (71 ± 4 years) community-dwelling men. Participants received transdermal T at either 5 or 10 g/day as well as rhGH at 0, 3.0 or 5.0 μg/kg/day for 16 weeks. Body composition was determined by dual-energy X-ray absorptiometry (DEXA) and muscle performance by composite one-repetition maximum (1-RM) strength and strength per unit of lean mass (muscle quality, MQ) for five major muscle groups (upper and lower body) at baseline, week 8 and 17. The average change in total LM at study week 8 compared with baseline was 1.50 ± 1.54 kg (P muscle performance did not show substantive improvements at this time point.

  15. The Final Fates of Accreting Supermassive Stars

    CERN Document Server

    Umeda, Hideyuki; Omukai, Kazuyuki; Yoshida, Naoki

    2016-01-01

    The formation of supermassive stars (SMSs) via rapid mass accretion and their direct collapse into black holes (BHs) is a promising pathway for sowing seeds of supermassive BHs in the early universe. We calculate the evolution of rapidly accreting SMSs by solving the stellar structure equations including nuclear burning as well as general relativistic (GR) effects up to the onset of the collapse. We find that such SMSs have less concentrated structure than fully-convective counterpart, which is often postulated for non-accreting ones. This effect stabilizes the stars against GR instability even above the classical upper mass limit $\\gtrsim 10^5~M_\\odot$ derived for the fully-convective stars. The accreting SMS begins to collapse at the higher mass with the higher accretion rate. The collapse occurs when the nuclear fuel is exhausted only for cases with $\\dot M \\lesssim 0.1~M_\\odot~{\\rm yr}^{-1}$. With $\\dot{M} \\simeq 0.3 - 1~M_\\odot~{\\rm yr}^{-1}$, the star becomes GR-unstable during the helium-burning stage ...

  16. The accretion of migrating giant planets

    CERN Document Server

    Dürmann, Christoph

    2016-01-01

    Most studies concerning the growth and evolution of massive planets focus either on their accretion or their migration only. In this work we study both processes concurrently to investigate how they might mutually affect each other. We modeled a 2-dimensional disk with a steady accretion flow onto the central star and embed a Jupiter mass planet at 5.2 au. The disk is locally isothermal and viscosity is modeled using a constant $\\alpha$. The planet is held on a fixed orbit for a few hundred orbits to allow the disk to adapt and carve a gap. After this period, the planet is released and free to move according to the gravitational interaction with the gas disk. The mass accretion onto the planet is modeled by removing a fraction of gas from the inner Hill sphere, and the removed mass and momentum can be added to the planet. Our results show that a fast migrating planet is able to accrete more gas than a slower migrating planet. Utilizing a tracer fluid we analyzed the origin of the accreted gas which comes pred...

  17. Lean mass, muscle strength and gene expression in community dwelling older men: findings from the Hertfordshire Sarcopenia Study (HSS).

    Science.gov (United States)

    Patel, Harnish P; Al-Shanti, Nasser; Davies, Lucy C; Barton, Sheila J; Grounds, Miranda D; Tellam, Ross L; Stewart, Claire E; Cooper, Cyrus; Sayer, Avan Aihie

    2014-10-01

    Sarcopenia is associated with adverse health outcomes. This study investigated whether skeletal muscle gene expression was associated with lean mass and grip strength in community-dwelling older men. Utilising a cross-sectional study design, lean muscle mass and grip strength were measured in 88 men aged 68-76 years. Expression profiles of 44 genes implicated in the cellular regulation of skeletal muscle were determined. Serum was analysed for circulating cytokines TNF (tumour necrosis factor), IL-6 (interleukin 6, IFNG (interferon gamma), IL1R1 (interleukin-1 receptor-1). Relationships between skeletal muscle gene expression, circulating cytokines, lean mass and grip strength were examined. Participant groups with higher and lower values of lean muscle mass (n = 18) and strength (n = 20) were used in the analysis of gene expression fold change. Expression of VDR (vitamin D receptor) [fold change (FC) 0.52, standard error for fold change (SE) ± 0.08, p = 0.01] and IFNG mRNA (FC 0.31; SE ± 0.19, p = 0.01) were lower in those with higher lean mass. Expression of IL-6 (FC 0.43; SE ± 0.13, p = 0.02), TNF (FC 0.52; SE ± 0.10, p = 0.02), IL1R1 (FC 0.63; SE ± 0.09, p = 0.04) and MSTN (myostatin) (FC 0.64; SE ± 0.11, p = 0.04) were lower in those with higher grip strength. No other significant changes were observed. Significant negative correlations between serum IL-6 (R = -0.29, p = 0.005), TNF (R = -0.24, p = 0.017) and grip strength were demonstrated. This novel skeletal muscle gene expression study carried out within a well-characterized epidemiological birth cohort has demonstrated that lower expression of VDR and IFNG is associated with higher lean mass, and lower expression of IL-6, TNF, IL1R1 and myostatin is associated with higher grip strength. These findings are consistent with a role of proinflammatory factors in mediating lower muscle strength in community-dwelling older men.

  18. Plantaris muscle weakness in old mice: relative contributions of changes in specific force, muscle mass, myofiber cross-sectional area, and number.

    Science.gov (United States)

    Ballak, Sam B; Degens, Hans; Busé-Pot, Tinelies; de Haan, Arnold; Jaspers, Richard T

    2014-01-01

    The age-related decline in muscle function contributes to the movement limitations in daily life in old age. The age-related loss in muscle force is attributable to loss of myofibers, myofiber atrophy, and a reduction in specific force. The contribution of each of these determinants to muscle weakness in old age is, however, largely unknown. The objective of this study is to determine whether a loss in myofiber number, myofiber atrophy, and a reduction in specific muscle force contribute to the age-related loss of muscle force in 25-month-old mouse. Maximal isometric force of in situ m. plantaris of C57BL/6J male adult (9 months) and old (25 months) mice was determined and related to myofiber number, myofiber size, intramuscular connective tissue content, and proportion of denervated myofibers. Isometric maximal plantaris muscle force was 13 % lower in old than adult mice (0.97 ± 0.05 N vs. 0.84 ± 0.03 N; P < 0.05). M. plantaris mass of old mice was not significantly smaller than that of adult mice. There was also no significant myofiber atrophy or myofiber loss. Specific muscle force of old mice was 25 % lower than that of adult mice (0.55 ± 0.05 vs. 0.41 ± 0.03 N·mm(-2), P < 0.01). In addition, with age, the proportion of type IIB myofibers decreased (43.6 vs. 38.4 %, respectively), while the connective tissue content increased (11.6 vs. 16.4 %, respectively). The age-related reduction in maximal isometric plantaris muscle force in 25-month-old male C57BL/6J mice is mainly attributable to a reduction in specific force, which is for 5 % explicable by an age-related increase in connective tissue, rather than myofiber atrophy and myofiber loss.

  19. Skeletal muscle mass and quality as risk factors for postoperative outcome after open colon resection for cancer.

    Science.gov (United States)

    Boer, B C; de Graaff, F; Brusse-Keizer, M; Bouman, D E; Slump, C H; Slee-Valentijn, M; Klaase, J M

    2016-06-01

    The prevalence of colorectal cancer in the elderly is increasing and, therefore, surgical interventions with a risk of potential complications are more frequently performed. This study investigated the role of low skeletal muscle mass (sarcopenia), muscle quality, and the sarcopenic obesity as prognostic factors for postoperative complications and survival in patients with resectable colon cancer. We conducted a retrospective chart review of 91 consecutive patients who underwent an elective open colon resection for cancer with primary anastomosis between 2011 and 2013. Skeletal muscle mass was measured as total psoas area (TPA) and total abdominal muscle area (TAMA) at three anatomical levels on the preoperative CT scan. Skeletal muscle quality was measured using corresponding mean Hounsfield units (HU) for TAMA. Their relation with complications (none vs one or more), severe complications, and survival was analyzed. The study included 91 patients with a mean age of 71.2 ± 9.7 years. Complications were noted in 55 patients (60 %), of which 15 (16.4 %) were severe. Lower HU for TAMA, as an indicator for impaired skeletal muscle quality, was an independent risk factor for one or more complications (all P ≤ 0.002), while sarcopenic obesity (TPA) was an independent risk factor for severe complications (all P ≤ 0.008). Sarcopenia was an independent predictor of worse overall survival (HR 8.54; 95 % confidence interval (CI) 1.07-68.32). Skeletal muscle quality is a predictor for overall complications, whereas sarcopenic obesity is a predictor for severe postoperative complications after open colon resection for cancer. Sarcopenia on itself is a predictor for worse overall survival.

  20. Generalized Similarity for Accretion/Decretion Disks

    Science.gov (United States)

    Rafikov, Roman R.

    2016-10-01

    Decretion (or external) disks are gas disks freely expanding to large radii due to their internal stresses. They are expected to naturally arise in tidal disruption events, around Be stars, in mass-losing post-main-sequence binaries, as a result of supernova fallback, etc. Their evolution is theoretically understood in two regimes: when the central object does not exert torque on the disk (a standard assumption for conventional accretion disks) or when no mass inflow (or outflow) occurs at the disk center. However, many astrophysical objects—circumbinary disks, Be stars, neutron stars accreting in a propeller regime, etc.—feature non-zero torque simultaneously with the non-zero accretion (or ejection of mass) at the disk center. We provide a general description for the evolution of such disks (both linear and nonlinear) in the self-similar regime, to which the disk should asymptotically converge with time. We identify a similarity parameter λ, which is uniquely related to the degree, to which the central mass accretion is suppressed by the non-zero central torque. The known decretion disk solutions correspond to the two discrete values of λ, while our new solutions cover a continuum of its physically allowed values, corresponding to either accretion or mass ejection by the central object. A direct relationship between λ and central \\dot{M} and torque is also established. We describe the time evolution of the various disk characteristics for different λ, and show that the observable properties (spectrum and luminosity evolution) of the decretion disks, in general, are different from the standard accretion disks with no central torque.

  1. Administration of soluble activin receptor 2B increases bone and muscle mass in a mouse model of osteogenesis imperfecta

    Institute of Scientific and Technical Information of China (English)

    Douglas J DiGirolamo; Vandana Singhal; Xiaoli Chang; Se-Jin Lee; Emily L Germain-Lee

    2015-01-01

    Osteogenesis imperfecta (OI) comprises a group of heritable connective tissue disorders generally defined by recurrent fractures, low bone mass, short stature and skeletal fragility. Beyond the skeletal complications of OI, many patients also report intolerance to physical activity, fatigue and muscle weakness. Indeed, recent studies have demonstrated that skeletal muscle is also negatively affected by OI, both directly and indirectly. Given the well-established interdependence of bone and skeletal muscle in both physiology and pathophysiology and the observations of skeletal muscle pathology in patients with OI, we investigated the therapeutic potential of simultaneous anabolic targeting of both bone and skeletal muscle using a soluble activin receptor 2B (ACVR2B) in a mouse model of type III OI (oim). Treatment of 12-week-old oim mice with ACVR2B for 4 weeks resulted in significant increases in both bone and muscle that were similar to those observed in healthy, wild-type littermates. This proof of concept study provides encouraging evidence for a holistic approach to treating the deleterious consequences of OI in the musculoskeletal system.

  2. Administration of soluble activin receptor 2B increases bone and muscle mass in a mouse model of osteogenesis imperfecta

    Science.gov (United States)

    DiGirolamo, Douglas J.; Singhal, Vandana; Chang, Xiaoli; Lee, Se-Jin; Germain-Lee, Emily L.

    2015-01-01

    Osteogenesis imperfecta (OI) comprises a group of heritable connective tissue disorders generally defined by recurrent fractures, low bone mass, short stature and skeletal fragility. Beyond the skeletal complications of OI, many patients also report intolerance to physical activity, fatigue and muscle weakness. Indeed, recent studies have demonstrated that skeletal muscle is also negatively affected by OI, both directly and indirectly. Given the well-established interdependence of bone and skeletal muscle in both physiology and pathophysiology and the observations of skeletal muscle pathology in patients with OI, we investigated the therapeutic potential of simultaneous anabolic targeting of both bone and skeletal muscle using a soluble activin receptor 2B (ACVR2B) in a mouse model of type III OI (oim). Treatment of 12-week-old oim mice with ACVR2B for 4 weeks resulted in significant increases in both bone and muscle that were similar to those observed in healthy, wild-type littermates. This proof of concept study provides encouraging evidence for a holistic approach to treating the deleterious consequences of OI in the musculoskeletal system. PMID:26161291

  3. Pre-Hospital Dietary Intake Correlates with Muscle Mass at the Time of Fracture in Older Hip-Fractured Patients

    Science.gov (United States)

    Calvani, Riccardo; Martone, Anna Maria; Marzetti, Emanuele; Onder, Graziano; Savera, Giulia; Lorenzi, Maria; Serafini, Elisabetta; Bernabei, Roberto; Landi, Francesco

    2014-01-01

    Background: Failure to meet an adequate dietary intake is involved in the pathogenesis of sarcopenia and osteoporosis, which in turn increase the risk for falls and fractures, respectively. Older people with hip fracture are often protein-malnourished at hospitalization. Whether low protein-energy intake is associated with muscle atrophy in hip-fractured patients is presently unknown. This information is necessary for the development of novel strategies to manage this especially vulnerable patient population. The aim of this study was, therefore, to explore the relationship between dietary intake and muscle mass in older hip-fractured patients. Methods: Analyses were conducted in hip-fractured elderly admitted to an orthopedic and trauma surgery ward (University Hospital). Muscle mass was estimated by bioelectrical impedance analysis within 24 h from admission. Dietary information was collected via 24-h dietary recall and nutrient intake calculated by a nutrition software. Results: Among 62 hip-fractured patients (mean age 84.6 ± 7.6 years, 84% women), the average energy intake was 929.2 ± 170.3 Kcal day−1, with higher values reported by men (1.046.8 ± 231.4 Kcal day−1) relative to women (906.5 ± 148.3 Kcal day−1; p = 0.01). Absolute and normalized protein intake was 50.0 ± 13.5 g day−1 and 0.88 ± 0.27 g kg (body weight)–1 day–1, respectively, with no gender differences. A positive correlation was determined between total energy intake and muscle mass (r = 0.384; p = 0.003). Similarly, protein and leucine consumption was positively correlated with muscle mass (r = 0.367 and 0.311, respectively; p = 0.005 for both). Conclusion: A low intake of calories, protein, and leucine is associated with reduced muscle mass in hip-fractured elderly. Given the relevance of sarcopenia as a risk factor for adverse outcomes in this patient population, our findings highlight the importance of a

  4. Pre-hospital dietary intake correlates with muscle mass at the time of fracture in older hip fractured patients

    Directory of Open Access Journals (Sweden)

    Riccardo eCalvani

    2014-11-01

    Full Text Available Background. Failure to meet an adequate dietary intake is involved in the pathogenesis of sarcopenia and osteoporosis, which in turn increase the risk for falls and fractures, respectively. Older people with hip fracture are often protein-malnourished at hospitalization. Whether low protein-energy intake is associated with muscle atrophy in hip fractured patients is presently unknown. This information is necessary for the development of novel strategies to manage this especially vulnerable patient population. The aim of this study was therefore to explore the relationship between dietary intake and muscle mass in older hip fractured patients.Methods. Analyses were conducted in hip fractured elderly admitted to an orthopedic and trauma surgery ward (University Hospital. Muscle mass was estimated by bioelectrical impedance analysis within 24 h from admission. Dietary information was collected via 24-h dietary recall and nutrient intakes calculated by a nutrition software.Results. Among 62 hip fractured patients (mean age 84.6±7.6 years, 84% women, the average energy intake was 929.2±170.3 Kcal/day, with higher values reported by men (1.046.8±231.4 Kcal/day relative to women (906.5±148.3 Kcal/day; p=0.01. Absolute and normalized protein intake was 50.0±13.5 g/day and 0.88±0.27 g/kg (body weight/day, respectively, with no gender differences. A positive correlation was determined between total energy intake and muscle mass (r=0.384; p=0.003. Similarly, protein and leucine consumption was positively correlated with muscle mass (r=0.367 and 0.311, respectively; p=0.005 for both.Conclusions. A low intake of calories, protein and leucine is associated with reduced muscle mass in hip fractured elderly. Given the relevance of sarcopenia as a risk factor for adverse outcomes in this patient population, our findings highlight the importance of a comprehensive dietary assessment for the detection of nutritional deficits predisposing to or aggravating

  5. Magnetohydrodynamic Origin of Jets from Accretion Disks

    CERN Document Server

    Lovelace, R V E; Koldoba, A V

    1999-01-01

    A review is made of recent magnetohydrodynamic (MHD) theory and simulations of origin of jets from accretion disks. Many compact astrophysical objects emit powerful, highly-collimated, oppositely directed jets. Included are the extra galactic radio jets of active galaxies and quasars, and old compact stars in binaries, and emission line jets in young stellar objects. It is widely thought that these different jets arise from rotating, conducting accretion disks threaded by an ordered magnetic field. The twisting of the magnetic field by the rotation of the disk drives the jets by magnetically extracting matter, angular momentum, and energy from the accretion disk. Two main regimes have been discussed theoretically, hydromagnetic winds which have a significant mass flux, and Poynting flux jets where the mass flux is negligible. Over the past several years, exciting new developments on models of jets have come from progress in MHD simulations which now allow the study of the origin - the acceleration and collima...

  6. Reverberation Mapping of AGN Accretion Disks

    Science.gov (United States)

    Fausnaugh, Michael; AGN STORM Collaboration

    2017-01-01

    I will discuss new reverberation mapping results that allow us to investigate the temperature structure of AGN accretion disks. By measuring time-delays between broad-band continuum light curves, we can determine the size of the disk as a function of wavelength. I will discuss the detection of continuum lags in NGC 5548 reported by the AGN STORM project and implications for the accretion disk. I will also present evidence for continuum lags in two other AGN for which we recently measured black hole masses from continuum-Hbeta reverberations. The mass measurements allow us to compare the continuum lags to predictions from standard thin disk theory, and our results indicate that the accretion disks are larger than the simplest expectations.

  7. Observations of Accreting Pulsars

    Science.gov (United States)

    Bildsten, Lars; Chakrabarty, Deepto; Chiu, John; Finger, Mark H.; Koh, Danny T.; Nelson, Robert W.; Prince, Thomas A.; Rubin, Bradley C.; Scott, D. Matthew; Stollberg, Mark; Vaughan, Brian A.; Wilson, Colleen A.; Wilson, Robert B.

    1997-01-01

    We summarize 5 years of continuous monitoring of accretion-powered pulsars with the Burst and Transient Source Experiment (BATSE) on the Compton Gamma Ray Observatory. Our 20-70 keV observations have determined or refined the orbital parameters of 13 binaries, discovered five new transient accreting pulsars, measured the pulsed flux history during outbursts of 12 transients (GRO J1744-28, 4U 0115+634, GRO J1750-27, GS 0834-430, 2S 1417-624, GRO J1948+32, EXO 2030+375, GRO J1008-57, A0535+26, GRO J2058+42, 4U 1145-619, and A1118-616), and also measured the accretion torque history during outbursts of six of those transients whose orbital param- eters were also known. We have also continuously measured the pulsed flux and spin frequency for eiaht persistently accreting pulsars (Her X-1, Cen X-3, Vela X-1, OAO 1657-415, GX 301-2, 4U 1626-67, 4U 1538-52, and GX 1+4). Because of their continuity and uniformity over a long baseline, BATSE observations have provided new insights into the long-term behavior of accreting magnetic neutron stars. We have found that all accreting pulsars show stochastic variations in their spin frequencies and luminosities, including those displaying secular spin-up or spin-down on long timescales, which blurs the con- ventional distinction between disk-fed and wind-fed binaries. Pulsed flux and accretion torque are strongly correlated in outbursts of transient accreting pulsars but are uncorrelated, or even anti- correlated, in persistent sources. We describe daily folded pulse profiles, frequency, and flux measurements that are available through the Compton Observatory Science Support Center at NASA/Goddard Space Flight Center.

  8. Accretion and evaporation of modified Hayward black hole

    Energy Technology Data Exchange (ETDEWEB)

    Debnath, Ujjal [Indian Institute of Engineering Science and Technology, Department of Mathematics, Howrah (India)

    2015-03-01

    We assume the most general static spherically symmetric black hole metric. The accretion of any general kind of fluid flow around the black hole is investigated. The accretion of the fluid flow around the modified Hayward black hole is analyzed, and we then calculate the critical point, the fluid's four-velocity, and the velocity of sound during the accretion process. Also the nature of the dynamical mass of the black hole during accretion of the fluid flow, taking into consideration Hawking radiation from the black hole, i.e., evaporation of the black hole, is analyzed. (orig.)

  9. Accretion Onto a Charged Higher-Dimensional Black Hole

    CERN Document Server

    Sharif, M

    2016-01-01

    This paper deals with the steady-state polytropic fluid accretion onto a higher-dimensional Reissner-Nordstr$\\ddot{o}$m black hole. We formulate the generalized mass flux conservation equation, energy flux conservation and relativistic Bernoulli equation to discuss the accretion process. The critical accretion is investigated by finding critical radius, critical sound velocity and critical flow velocity. We also explore gas compression and temperature profiles to analyze the asymptotic behavior. It is found that the results for Schwarzschild black hole are recovered when $q=0$ in four dimensions. We conclude that accretion process in higher dimensions becomes slower in the presence of charge.

  10. Superhumps, resonances and accretion discs

    Energy Technology Data Exchange (ETDEWEB)

    Whitehurst, R.; King, A. (Leicester Univ. (UK). Dept. of Astronomy)

    1991-03-01

    The structure of accretion discs within binary systems is shown to be influenced by the excitation of resonances within the disc. Of particular importance is that near the 3:1 commensurability with the stars' orbit. This can be used to explain the superhump phenomenon of SU Ursae Majoris dwarf novae in superoutburst. This resonance can only appear for mass ratios which satisfy M{sub 2}/M{sub 1} < {approx equal} 0.25-0.33: for larger mass ratios the available resonances are weaker and of the wrong form to produce the superhump phenomenon. The mass-transfer stream is shown to be an important contributor to the growth rate of the resonance. (author).

  11. Quasistars: Accreting black holes inside massive envelopes

    CERN Document Server

    Begelman, Mitchell C; Armitage, Philip J

    2007-01-01

    We study the structure and evolution of "quasistars," accreting black holes embedded within massive hydrostatic gaseous envelopes. These configurations may model the early growth of supermassive black hole seeds. The accretion rate onto the black hole adjusts so that the luminosity carried by the convective envelope equals the Eddington limit for the total mass. This greatly exceeds the Eddington limit for the black hole mass alone, leading to rapid growth of the black hole. We use analytic models and numerical stellar structure calculations to study the structure and evolution of quasistars. We derive analytically the scaling of the photospheric temperature with the black hole mass and envelope mass, and show that it decreases with time as the black hole mass increases. Once the photospheric temperature becomes lower than 10000 K, the photospheric opacity drops precipitously and the photospheric temperature hits a limiting value, analogous to the Hayashi track for red giants and protostars, below which no hy...

  12. Bondi accretion in the early universe

    CERN Document Server

    Ricotti, Massimo

    2007-01-01

    This paper presents a study of quasi-steady spherical accretion in the early Universe, before the formation of the first stars and galaxies. The main motivation is to derive the basic formulas that will be used in a companion paper to calculate the accretion luminosity of primordial black holes and their effect on the cosmic ionization history. The following cosmological effects are investigated: the coupling of the gas to the CMB photon fluid (i.e., Compton drag), Hubble expansion, and the growth of the dark matter halo seeded by the gravitational potential of the central point mass. The gas equations of motion are solved assuming either a polytropic or an isothermal equation of state. We consider the cases in which the accreting object is a point mass or a spherical dark matter halo with power-law density profile, as predicted by the theory of "secondary infall''. Analytical solutions for the sonic radius and fitting formulas for the accretion rate are provided. Different accretion regimes exist depending o...

  13. Accretion Rates in Herbig Ae stars

    CERN Document Server

    López, R G; Testi, L; Habart, E

    2006-01-01

    Accretion rates from disks around pre-main sequence stars are of importance for our understanding of planetary formation and disk evolution. We provide in this paper estimates of the mass accretion rates in the disks around a large sample of Herbig Ae stars. We obtained medium resolution 2 micron spectra and used the results to compute values of Macc from the measured luminosity of the Br_gamma emission line, using a well established correlation between L(Br_gamma) and the accretion luminosity Lacc. We find that 80% of the stars, all of which have evidence of an associated circumstellar disk, are accreting matter, with rates 3x10^{-9} 10^{-7} Msun/yr. In most HAe stars the accretion rate is sufficiently low that the gas in the inner disk, inside the dust evaporation radius, is optically thin and does not prevent the formation of a puffed-up rim, where dust is directly exposed to the stellar radiation. When compared to the Macc values found for lower-mass stars in the star forming regions Taurus and Ophiuchus,...

  14. Is increase in bone mineral content caused by increase in skeletal muscle mass/strength in adult patients with GH-treated GH deficiency? A systematic literature analysis

    DEFF Research Database (Denmark)

    Klefter, O.; Feldt-Rasmussen, U.

    2009-01-01

    OBJECTIVE: Adult patients with GH deficiency (GHD) are characterized by a reduced muscle mass, but also reduced bone mineral density (BMD) and content (BMC), which have been ascribed to GHD per se. The aim of this study was to investigate if changes in BMD/BMC in adult GHD patients could be due...... performed a systematic literature analysis, including 51 clinical trials published between 1996 and 2008, which had studied the development in muscle mass, muscle strength, BMD, and/or BMC in GH-treated adult GHD patients. RESULTS: GH therapy had an anabolic effect on skeletal muscle. The largest increase...

  15. Effects of chronic high-fat feeding on skeletal muscle mass and function in middle-aged mice.

    Science.gov (United States)

    Lee, Sang-Rok; Khamoui, Andy V; Jo, Edward; Park, Bong-Sup; Zourdos, Michael C; Panton, Lynn B; Ormsbee, Michael J; Kim, Jeong-Su

    2015-08-01

    Increased adipose tissue may promote catabolic events in skeletal muscle. The aim of this study was to test whether high-fat diet (HFD)-induced obesity would accelerate the onset of muscle wasting in middle-aged mice. Muscle was collected from C57BL/6 mice at 9 months of age (baseline) and 14 months of age after consuming a control (C) or HFD. Mice in C and HFD were also subjected to evaluations of body composition and function before and after their respective diets. HFD demonstrated significant (p decreased to a greater degree in HFD although not significantly (C: -20.69 ± 7.94 vs. HFD: -31.14 ± 5.49 %, p > 0.05). Gastrocnemius, quadriceps, and hamstrings mass in C and HFD were significantly reduced from baseline (-27 to 43 and -39 to 47 %, respectively, p muscle to HFD-dependent catabolism more so than aging. In the muscles containing fast/mixed fibers, aging effects may have concealed the catabolic nature of HFD; however, morphological changes in the gastrocnemius including decreased fiber area, satellite cells, and myonuclei are consistent with an atrophic phenotype related to HFD.

  16. Natural history of skeletal muscle mass changes in chronic kidney disease stage 4 and 5 patients: an observational study.

    Directory of Open Access Journals (Sweden)

    Stephen G John

    Full Text Available Cross-sectional studies in dialysis demonstrate muscle wasting associated with loss of function, increased morbidity and mortality. The relative drivers are poorly understood. There is a paucity of data regarding interval change in muscle in pre-dialysis and dialysis-dependant patients. This study aimed to examine muscle and fat mass change and elucidate associations with muscle wasting in advanced CKD. 134 patients were studied (60 HD, 28 PD, 46 CKD 4-5 and followed up for two years. Groups were similar in age, sex and diabetes prevalence. Soft tissue cross-sectional area (CSA was measured annually on 3 occasions by a standardised multi-slice CT thigh. Potential determinants of muscle and fat CSA were assessed. Functional ability was assessed by sit-to-stand testing. 88 patients completed follow-up (40 HD, 16 PD, 32 CKD. There was a significant difference in percentage change in muscle CSA (MCSA over year 1, dependant on treatment modality (χ(2 = 6.46; p = 0.039. Muscle loss was most pronounced in pre-dialysis patients. Muscle loss during year 1 was partially reversed in year 2 in 39%. Incident dialysis patients significantly lost MCSA during the year which they commenced dialysis, but not the subsequent year. Baseline MCSA, change in MCSA during year 1 and dialysis modality predicted year 2 change in MCSA (adjusted R(2 = 0.77, p<0.001. There was no correlation between muscle or fat CSA change and any other factors. MCSA correlated with functional testing, although MCSA change correlated poorly with change in functional ability. These data demonstrate marked variability in MCSA over 2 years. Loss of MCSA in both pre-dialysis and established dialysis patients is reversible. Factors previously cross-sectionally shown to correlate with MCSA did not correlate with wasting progression. The higher rate of muscle loss in undialysed CKD patients, and its reversal after dialysis commencement, suggests that conventional indicators may not

  17. 低质量X射线双星的长期监测和吸积物理%Monitoring Observations of Low Mass X-ray Binary and Accretion Physics

    Institute of Scientific and Technical Information of China (English)

    闫震

    2011-01-01

    In this thesis, we have performed the multi-wavelength monitoring observations of Galactic low-mass X-ray binaries and studied the X-ray spectral evolution and spectral state transitions in bright X-ray binaries, the properties of transient sources during the outbursts and the evolution of multi-wavelength emission during the outburst and the relation between different wavelengths. The large dynamical range of X-ray luminosity is invaluable for studying the accretion physics, since we can watch the evolution of the system through the full range of accretion rates and follow causal sequences between them. The results of our study improve our understanding of accretion physics, especially in some unresolved problems, such as the key role in determining the X-ray spectral transitions, the relation between jet and X-ray spectral states and the origin of emission in different X-ray spectral states.Firstly, we systematically studied the different spectral states and state transitions in the bright Galactic X-ray binaries during the past more than ten years. We could study the long term evolution in different energy bands by using the soft (2-12 keV) and hard (15-50 keV) X-ray monitoring light curves. The hardnessratio of the two energy band can be used to describe the X-ray spectral evolution and define the spectral states and state transitions. We confirmed that the luminosity of hard-to-soft state transition positively correlates with the peak luminosity of following soft state, and also found positively correlation between the luminosity of hard-to-soft state transition and the rate-of-increase of luminosity. These two empirical correlations indicate that the brightest hard state and the hard-to-soft state transition are determined by the non-stationary accretion which is characterised by the rate-of-increase of mass accretion rate. Both correlations do not show any saturation or cut-off in the high luminosity end, which implies that the brighter outbursts and

  18. Genetic variations in the androgen receptor are associated with steroid concentrations and anthropometrics but not with muscle mass in healthy young men.

    Directory of Open Access Journals (Sweden)

    Hélène De Naeyer

    Full Text Available OBJECTIVE: The relationship between serum testosterone (T levels, muscle mass and muscle force in eugonadal men is incompletely understood. As polymorphisms in the androgen receptor (AR gene cause differences in androgen sensitivity, no straightforward correlation can be observed between the interindividual variation in T levels and different phenotypes. Therefore, we aim to investigate the relationship between genetic variations in the AR, circulating androgens and muscle mass and function in young healthy male siblings. DESIGN: 677 men (25-45 years were recruited in a cross-sectional, population-based sibling pair study. METHODS: Relations between genetic variation in the AR gene (CAGn, GGNn, SNPs, sex steroid levels (by LC-MS/MS, body composition (by DXA, muscle cross-sectional area (CSA (by pQCT, muscle force (isokinetic peak torque, grip strength and anthropometrics were studied using linear mixed-effect modelling. RESULTS: Muscle mass and force were highly heritable and related to age, physical activity, body composition and anthropometrics. Total T (TT and free T (FT levels were positively related to muscle CSA, whereas estradiol (E2 and free E2 (FE2 concentrations were negatively associated with muscle force. Subjects with longer CAG repeat length had higher circulating TT, FT, and higher E2 and FE2 concentrations. Weak associations with TT and FT were found for the rs5965433 and rs5919392 SNP in the AR, whereas no association between GGN repeat polymorphism and T concentrations were found. Arm span and 2D:4D finger length ratio were inversely associated, whereas muscle mass and force were not associated with the number of CAG repeats. CONCLUSIONS: Age, physical activity, body composition, sex steroid levels and anthropometrics are determinants of muscle mass and function in young men. Although the number of CAG repeats of the AR are related to sex steroid levels and anthropometrics, we have no evidence that these variations in the AR

  19. Simulating a Thin Accretion Disk Using PLUTO

    Science.gov (United States)

    Phillipson, Rebecca; Vogeley, Michael S.; Boyd, Patricia T.

    2017-08-01

    Accreting black hole systems such as X-ray binaries and active galactic nuclei exhibit variability in their luminosity on many timescales ranging from milliseconds to tens of days, and even hundreds of days. The mechanism(s) driving this variability and the relationship between short- and long-term variability is poorly understood. Current studies on accretion disks seek to determine how the changes in black hole mass, the rate at which mass accretes onto the central black hole, and the external environment affect the variability on scales ranging from stellar-mass black holes to supermassive black holes. Traditionally, the fluid mechanics equations governing accretion disks have been simplified by considering only the kinematics of the disk, and perhaps magnetic fields, in order for their phenomenological behavior to be predicted analytically. We seek to employ numerical techniques to study accretion disks including more complicated physics traditionally ignored in order to more accurately understand their behavior over time. We present a proof-of-concept three dimensional, global simulation using the astrophysical hydrodynamic code PLUTO of a simplified thin disk model about a central black hole which will serve as the basis for development of more complicated models including external effects such as radiation and magnetic fields. We also develop a tool to generate a synthetic light curve that displays the variability in luminosity of the simulation over time. The preliminary simulation and accompanying synthetic light curve demonstrate that PLUTO is a reliable code to perform sophisticated simulations of accretion disk systems which can then be compared to observational results.

  20. Clinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Zhe-rong Xu

    Full Text Available A major reason for the loss of mobility in elderly people is the gradual loss of lean body mass known as sarcopenia. Sarcopenia is associated with a lower quality of life and higher healthcare costs. The benefit of strategies that include nutritional intervention, timing of intervention, and physical exercise to improve muscle loss unclear as finding from studies investigating this issue have been inconsistent. We have performed a systematic review and meta-analysis to assess the ability of protein or amino acid supplementation to augment lean body mass or strength of leg muscles in elderly patients.Nine studies met the inclusion criteria of being a prospective comparative study or randomized controlled trial (RCT that compared the efficacy of an amino acid or protein supplement intervention with that of a placebo in elderly people (≥ 65 years for the improvement of lean body mass (LBM, leg muscle strength or reduction associated with sarcopenia.The overall difference in mean change from baseline to the end of study in LBM between the treatment and placebo groups was 0.34 kg which was not significant (P = 0.386. The overall differences in mean change from baseline in double leg press and leg extension were 2.14 kg (P = 0.748 and 2.28 kg (P = 0.265, respectively, between the treatment group and the placebo group.These results indicate that amino acid/protein supplements did not increase lean body mass gain and muscle strength significantly more than placebo in a diverse elderly population.

  1. SPIN EVOLUTION OF ACCRETING YOUNG STARS. II. EFFECT OF ACCRETION-POWERED STELLAR WINDS

    Energy Technology Data Exchange (ETDEWEB)

    Matt, Sean P. [Laboratoire AIM Paris-Saclay, CEA/Irfu Universite Paris-Diderot CNRS/INSU, 91191 Gif-sur-Yvette (France); Pinzon, Giovanni [Observatorio Astronomico Nacional, Facultad de Ciencias, Universidad Nacional de Colombia, Bogota (Colombia); Greene, Thomas P. [NASA Ames Research Center, M.S. 245-6, Moffett Field, CA 94035-1000 (United States); Pudritz, Ralph E., E-mail: sean.matt@cea.fr, E-mail: thomas.p.greene@nasa.gov, E-mail: gapinzone@unal.edu.co, E-mail: pudritz@physics.mcmaster.ca [Physics and Astronomy Department, McMaster University, Hamilton, ON L8S 4M1 (Canada)

    2012-01-20

    We present a model for the rotational evolution of a young, solar-mass star interacting magnetically with an accretion disk. As in a previous paper (Paper I), the model includes changes in the star's mass and radius as it descends the Hayashi track, a decreasing accretion rate, and a prescription for the angular momentum transfer between the star and disk. Paper I concluded that, for the relatively strong magnetic coupling expected in real systems, additional processes are necessary to explain the existence of slowly rotating pre-main-sequence stars. In the present paper, we extend the stellar spin model to include the effect of a spin-down torque that arises from an accretion-powered stellar wind (APSW). For a range of magnetic field strengths, accretion rates, initial spin rates, and mass outflow rates, the modeled stars exhibit rotation periods within the range of 1-10 days in the age range of 1-3 Myr. This range coincides with the bulk of the observed rotation periods, with the slow rotators corresponding to stars with the lowest accretion rates, strongest magnetic fields, and/or highest stellar wind mass outflow rates. We also make a direct, quantitative comparison between the APSW scenario and the two types of disk-locking models (namely, the X-wind and Ghosh and Lamb type models) and identify some remaining theoretical issues for understanding young star spins.

  2. Human pharmacokinetics of the muscle relaxant, eperisone hydrochloride by liquid chromatography-electrospray tandem mass spectrometry.

    Science.gov (United States)

    Melilli, Barbara; Piazza, Cateno; Vitale, Daniela Cristina; Marano, Maria Rosa; Pecori, Andrea; Mattana, Paolo; Volsi, Valentina Li; Iuculano, Carmelo; Cardì, Francesco; Drago, Filippo

    2011-06-01

    Eperisone hydrochloride (4'-ethyl-2-methyl-3-piperidinopropiophenone hydrochloride) is a muscle relaxant agent, widely used in the treatment of patients with muscular contractures, low back pain or spasticity. Because of its mechanism of action (inhibition of gamma-efferent firing and local vasodilatation activity), side effects on central nervous system are rarely observed. A sensitive liquid chromatography-electrospray ionization-mass spectrometry method for determination of eperisone in human plasma has been developed, with a lower limit of quantification of 0.01 ng/mL. The method was applied to a pharmacokinetic study in 12 healthy volunteers given eperisone 100 mg as single dose on day 1 and three times daily on days 2 to 4. Eperisone was rapidly absorbed after oral administration (T (max) = 1.6 h) as it was expected by its fast-onset relaxant activity. Moreover, eperisone underwent a rapid elimination from the body (biological half-life 1.87 h), which was not modified during the repeated dosing as suggested by the C (max) cumulation observed, not different from that expected for a t (1/2) of 1.87 h as suggested by the similar and negligible plasma concentration values (0.063 and 0.067 ng/mL) measured on day 4 before the morning dose and 12 h after evening dose, thus ruling out any potential risk for drug accumulation. Thus, the pharmacokinetic characteristics of eperisone provide further justification for its tolerability in patients with low back pain or spastic palsy, in which the drug is given for periods ranging from few days to several months, respectively.

  3. Hemodynamic responses to small muscle mass exercise in heart failure patients with reduced ejection fraction

    Science.gov (United States)

    Barrett-O'Keefe, Zachary; Lee, Joshua F.; Berbert, Amanda; Witman, Melissa A. H.; Nativi-Nicolau, Jose; Stehlik, Josef; Richardson, Russell S.

    2014-01-01

    To better understand the mechanisms responsible for exercise intolerance in heart failure with reduced ejection fraction (HFrEF), the present study sought to evaluate the hemodynamic responses to small muscle mass exercise in this cohort. In 25 HFrEF patients (64 ± 2 yr) and 17 healthy, age-matched control subjects (64 ± 2 yr), mean arterial pressure (MAP), cardiac output (CO), and limb blood flow were examined during graded static-intermittent handgrip (HG) and dynamic single-leg knee-extensor (KE) exercise. During HG exercise, MAP increased similarly between groups. CO increased significantly (+1.3 ± 0.3 l/min) in the control group, but it remained unchanged across workloads in HFrEF patients. At 15% maximum voluntary contraction (MVC), forearm blood flow was similar between groups, while HFrEF patients exhibited an attenuated increase at the two highest intensities compared with controls, with the greatest difference at the highest workload (352 ± 22 vs. 492 ± 48 ml/min, HFrEF vs. control, 45% MVC). During KE exercise, MAP and CO increased similarly across work rates between groups. However, HFrEF patients exhibited a diminished leg hyperemic response across all work rates, with the most substantial decrement at the highest intensity (1,842 ± 64 vs. 2,675 ± 81 ml/min; HFrEF vs. control, 15 W). Together, these findings indicate a marked attenuation in exercising limb perfusion attributable to impairments in peripheral vasodilatory capacity during both arm and leg exercise in patients with HFrEF, which likely plays a role in limiting exercise capacity in this patient population. PMID:25260608

  4. Comparison of Balance, Proprioception and Skeletal Muscle Mass in Total Hip Replacement Patients With and Without Fracture: A Pilot Study

    Science.gov (United States)

    2016-01-01

    Objective To determine whether there was a difference in balance, proprioception, and skeletal muscle mass among patients who undergo hip fracture surgery relative to and elective total hip replacement (THR). Methods Thirty-one THR patients were enrolled. The patients were categorized into two groups: fracture group (n=15) and non-fracture group (n=16). Berg Balance Scale (BBS) was used to balance the proprioception of the hip joint while a joint position sense (JPS) test was used to evaluate it. Skeletal muscle mass was measured by bioelectrical impedance analysis and expressed as a skeletal muscle mass index (SMI). Quality of life (QOL) was also assessed using a 36-item short form health survey (SF-36). All tests were assessed at 3 months after the surgery. An independent t-test was used to compare the fracture group and non-fracture group. Spearman correlation was used to identify the correlation of each variable. Results In an independent t-test, the BBS score of patients undergoing elective surgery was higher than the BBS score of patients undergoing hip fracture surgery. There was a significant correlation between the BBS and JPS score after a THR. SMI also correlated with the score of BBS. Conclusion It seems that THR patients undergoing surgery for a hip fracture might have more trouble balancing than elective THR patients. Therefore THR patients undergoing hip fracture surgery might need more care during rehabilitation. PMID:28119837

  5. On the Eddington limit for relativistic accretion discs

    CERN Document Server

    Abolmasov, Pavel

    2015-01-01

    Standard accretion disc model relies upon several assumptions, the most important of which is geometrical thinness. Whenever this condition is violated, new physical effects become important such as radial energy advection and mass loss from the disc. These effects are important, for instance, for large mass accretion rates when the disc approaches its local Eddington limit. In this work, we study the upper limits for standard accretion disc approximation and find the corrections to the standard model that should be considered in any model aiming on reproducing the transition to super-Eddington accretion regime. First, we find that for thin accretion disc, taking into account relativistic corrections allows to increase the local Eddington limit by about a factor of two due to stronger gravity in General Relativity (GR). However, violation of the local Eddington limit also means large disc thickness. To consider consequently the disc thickness effects, one should make assumptions upon the two-dimensional rotat...

  6. The effect of rotation on the stability of nuclear burning in accreting neutron stars

    NARCIS (Netherlands)

    Keek, L.; Langer, N.; in 't Zand, J.J.M.

    2009-01-01

    Hydrogen and/or helium accreted by a neutron star from a binary companion may undergo thermonuclear fusion. Different burning regimes are discerned at different mass accretion rates. Theoretical models predict helium fusion to proceed as a thermonuclear runaway for accretion rates below the

  7. WIND-ACCRETION DISKS IN WIDE BINARIES, SECOND-GENERATION PROTOPLANETARY DISKS, AND ACCRETION ONTO WHITE DWARFS

    Energy Technology Data Exchange (ETDEWEB)

    Perets, Hagai B. [Technion-Israel Institute of Technology, Haifa (Israel); Kenyon, Scott J., E-mail: hperets@physics.technion.ac.il [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States)

    2013-02-20

    Mass transfer from an evolved donor star to its binary companion is a standard feature of stellar evolution in binaries. In wide binaries, the companion star captures some of the mass ejected in a wind by the primary star. The captured material forms an accretion disk. Here, we study the evolution of wind-accretion disks, using a numerical approach which allows us to follow the long-term evolution. For a broad range of initial conditions, we derive the radial density and temperature profiles of the disk. In most cases, wind accretion leads to long-lived stable disks over the lifetime of the asymptotic giant branch donor star. The disks have masses of a few times 10{sup -5}-10{sup -3} M {sub Sun }, with surface density and temperature profiles that follow broken power laws. The total mass in the disk scales approximately linearly with the viscosity parameter used. Roughly, 50%-80% of the mass falling into the disk accretes onto the central star; the rest flows out through the outer edge of the disk into the stellar wind of the primary. For systems with large accretion rates, the secondary accretes as much as 0.1 M {sub Sun }. When the secondary is a white dwarf, accretion naturally leads to nova and supernova eruptions. For all types of secondary star, the surface density and temperature profiles of massive disks resemble structures observed in protoplanetary disks, suggesting that coordinated observational programs might improve our understanding of uncertain disk physics.

  8. Age-associated declines in muscle mass, strength, power, and physical performance: impact on fear of falling and quality of life.

    Science.gov (United States)

    Trombetti, A; Reid, K F; Hars, M; Herrmann, F R; Pasha, E; Phillips, E M; Fielding, R A

    2016-02-01

    This 3-year longitudinal study among older adults showed that declining muscle mass, strength, power, and physical performance are independent contributing factors to increased fear of falling, while declines of muscle mass and physical performance contribute to deterioration of quality of life. Our findings reinforce the importance of preserving muscle health with advancing age. The age-associated loss of skeletal muscle quantity and function are critical determinants of independent physical functioning in later life. Longitudinal studies investigating how decrements in muscle components of sarcopenia impact fear of falling (FoF) and quality of life (QoL) in older adults are lacking. Twenty-six healthy older subjects (age, 74.1 ± 3.7; Short Physical Performance Battery (SPPB) score ≥10) and 22 mobility-limited older subjects (age, 77.2 ± 4.4; SPPB score ≤9) underwent evaluations of lower extremity muscle size and composition by computed tomography, strength and power, and physical performance at baseline and after 3-year follow-up. The Falls Efficacy Scale (FES) and Short Form-36 questionnaire (SF-36) were also administered at both timepoints to assess FoF and QoL, respectively. At 3-year follow-up, muscle cross-sectional area (CSA) (p power decreased (p muscle CSA, strength and power, and SPPB score were associated with increased FES score (p muscle CSA (p muscle mass, strength, power, and physical performance contribute independently to increase FoF, while declines of muscle mass and physical performance contribute to deterioration of QoL. These findings provide further rationale for developing interventions to improve aging muscle health.

  9. Beyond Body Mass Index. Is the Body Cell Mass Index (BCMI) a useful prognostic factor to describe nutritional, inflammation and muscle mass status in hospitalized elderly?: Body Cell Mass Index links in elderly.

    Science.gov (United States)

    Rondanelli, Mariangela; Talluri, Jacopo; Peroni, Gabriella; Donelli, Chiara; Guerriero, Fabio; Ferrini, Krizia; Riggi, Emilia; Sauta, Elisabetta; Perna, Simone; Guido, Davide

    2017-03-24

    The aim of this study was to establish the effectiveness of Body Cell Mass Index (BCMI) as a prognostic index of (mal)nutrition, inflammation and muscle mass status in the elderly. A cross-sectional observational study has been conducted on 114 elderly patients (80 women and 34 men), with mean age equal to 81.07 ± 6.18 years. We performed a multivariate regression model by Structural Equation Modelling (SEM) framework. We detected the effects over a Mini Nutritional Assessment (MNA) stratification, by performing a multi-group multivariate regression model (via SEM) in two MNA nutritional strata, less and bigger (or equal) than 17. BCMI had a significant effect on albumin (β = +0.062, P = 0.001), adjusting for the other predictors of the model as Body Mass Index (BMI), age, sex, fat mass and cognitive condition. An analogous result is maintained in MNABMI has confirmed to be a solid prognostic factor for both free fat mass (FFM) (β = +0.480, P Index (SMI) (β = +0.265, P BMI, proved to be significantly related to an important marker as albumin in geriatric population. Then, assessing the BCMI could be a valuable, inexpensive, easy to perform tool to investigate the inflammation status of elderly patients. Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  10. Gas accretion onto galaxies

    CERN Document Server

    Davé, Romeel

    2017-01-01

    This edited volume presents the current state of gas accretion studies from both observational and theoretical perspectives, and charts our progress towards answering the fundamental yet elusive question of how galaxies get their gas. Understanding how galaxies form and evolve has been a central focus in astronomy for over a century. These studies have accelerated in the new millennium, driven by two key advances: the establishment of a firm concordance cosmological model that provides the backbone on which galaxies form and grow, and the recognition that galaxies grow not in isolation but within a “cosmic ecosystem” that includes the vast reservoir of gas filling intergalactic space. This latter aspect in which galaxies continually exchange matter with the intergalactic medium via inflows and outflows has been dubbed the “baryon cycle”. The topic of this book is directly related to the baryon cycle, in particular its least well constrained aspect, namely gas accretion. Accretion is a rare area of ast...

  11. Probing thermonuclear burning on accreting neutron stars

    OpenAIRE

    Keek, L.

    2008-01-01

    Neutron stars are the most compact stars that can be directly observed, which makes them ideal laboratories to study physics at extreme densities. Neutron stars in low-mass X-ray binaries accrete hydrogen and helium from a lower-mass companion star through Roche lobe overflow. This matter undergoes thermonuclear burning in the neutron star envelope, creating carbon and heavier elements. The fusion process may proceed in an unstable manner, resulting in a thermonuclear runaway. Within one seco...

  12. Ratio of Dietary n-6/n-3 Polyunsaturated Fatty Acids Independently Related to Muscle Mass Decline in Hemodialysis Patients.

    Directory of Open Access Journals (Sweden)

    Te-Chih Wong

    Full Text Available n-3 polyunsaturated fatty acids (PUFAs might be useful nutritional strategy for treating patients with sarcopenia. We evaluated the effect of the intake of dietary n-3 PUFAs on the skeletal muscle mass (SMM, appendicular skeletal muscle mass (ASM, and its determinants in patients receiving standard hemodialysis (HD treatment for the management of end stage renal disease.In this cross-sectional study, data of 111 HD patients were analyzed. Anthropometric and bioelectrical impedance measurements used to estimate the muscle mass were performed the day of dialysis immediately after the dialysis session. Routine laboratory and 3-day dietary data were also collected. The cutoff value of adequate intake (AI for both n-3 PUFAs and alpha-linolenic acid (ALA was 1.6 g/day and 1.1 g/day for men and women, respectively.The mean age, mean dietary n-3 PUFAs intake, ALA intake, ratio of n-6/n-3 PUFAs intake, SMM, and ASM of patients were 61.4 ± 10.4 years, 2.0 ± 1.3 g/day, 1.5 ± 1.0 g/day, 9.5 ± 6.7 g/day, 23.9 ± 5.5 kg, and 17.5 ± 4.5 kg, respectively. A higher SMM and ASM significantly observed in patients who achieved an AI of n-3 PUFAs. Similar trends appeared to be observed among those patients who achieved the AI of ALA, but the difference was not significantly, except for ASM (P = 0.047. No relevant differences in demographics, laboratory and nutritional parameters were observed, regardless of whether the patients achieved an AI of n-3 PUFAs. Multivariate analysis showed that the BMI and equilibrated Kt/V were independent determinants of the muscle mass. Moreover, the ratio of n-6/n-3 PUFAs was an independent risk determinant of reduced ASM in HD patients.Patients with an AI of n-3 PUFAs had better total-body SMM and ASM. A higher dietary ratio of n-6/n-3 PUFAs seemed to be associated with a reduced muscle mass in HD patients.

  13. Association between muscle mass and adipo-metabolic profile: a cross-sectional study in older subjects

    Directory of Open Access Journals (Sweden)

    Perna S

    2015-02-01

    Full Text Available Simone Perna,1,* Davide Guido,2,* Mario Grassi,2 Mariangela Rondanelli1 1Department of Public Health, Experimental and Forensic Medicine, School of Medicine, Endocrinology and Nutrition Unit, University of Pavia, Azienda di Servizi alla Persona di Pavia, Pavia, Italy; 2Medical and Genomic Statistics Unit, Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy *These authors contributed equally to this work Background: Sarcopenia, the decrease in muscle mass and function, may lead to various negative health outcomes in elderly. The association among sarcopenia with adiposity and metabolic markers has rarely been studied in the elderly population, with controversial results. The aim of this study is to evaluate this relationship in older subjects.Methods: A cross-sectional study was conducted in 290 elderly patients, focusing on the possible association between muscle mass loss, assessed by relative skeletal muscle mass (RSMM, and an adipo-metabolic profile (AMP defined by adiposity and metabolic biochemical markers. Measurements of body composition were assessed by dual energy X-ray absorptiometry. Biochemical parameters, such as albumin, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, total cholesterol, triglycerides, C-reactive protein, and homocysteine and its related markers (folate and vitamin B12 were measured. Using canonical correlation analysis and structural equation modeling, an individual score of AMP was created and correlated with RSMM.Results: The AMP–RSMM correlation was equal to +0.642 (95% confidence interval, +0.512 to +0.773; P<0.001. Hence, a negative association between sarcopenia severity and adiposity/metabolic biochemical markers was highlighted.Conclusion: This study contained a novel way to examine the relationship between the variables of interest based on a composite index of adiposity and metabolic conditions. Results shed light on the orientation and magnitude of

  14. Strong Role of Non-stationary Accretion in Spectral Transitions of X-ray Binaries and Implications for Revealing the Accretion Geometry and Broadband Radiation Mechanisms

    Science.gov (United States)

    Yu, Wenfei; Yan, Zhen; Tang, Jing; Wu, Yuxiang

    Observations of spectral transitions from the hard state to the soft state in bright X-ray binaries show strong evidence that the rate-of-change of the mass accretion rate plays a dominant role in determining the luminosity at which the spectral transition occurs. This indicates that in many cases, especially accretion in transients during outbursts, the rate-of-change of the mass accretion rate is the primary parameter driving high energy phenomena. Although this goes beyond the scope of current stationary model of disk and jet, it tells us that it is the rate-of-change of the mass accretion rate that we need to trace observationally. Since state transition is a broadband phenomenon, multi-wavelength observations of spectral transitions of different rate-of-changes of mass accretion rate are expect to reveal the accretion geometry and broadband radiation mechanisms.

  15. Mass and fat infiltration of intercostal muscles measured by CT histogram analysis and their correlations with COPD severity.

    Science.gov (United States)

    Park, Mi Jung; Cho, Jae Min; Jeon, Kyung Nyeo; Bae, Kyung Soo; Kim, Ho Cheol; Choi, Dae Seob; Na, Jae Boem; Choi, Ho Cheol; Choi, Hye Young; Kim, Ji Eun; Shin, Hwa Seon

    2014-06-01

    Chronic obstructive pulmonary disease (COPD) is characterized by progressive respiratory function impairment and respiratory muscle dysfunction. We hypothesized that the mass and fat infiltration of respiratory muscles correlates with COPD severity and emphysema extent. Ninety-eight male patients with COPD underwent chest computed tomography (CT) and spirometry. The mass and fat infiltrations of intercostal and latissimus muscles were quantified as the cross-sectional area (CSA) and attenuation of these muscles using CT histogram analysis. Intercostal index and latissimus index were defined as intercostal CSAs and latissimus CSAs divided by body mass index. The emphysema extent was measured as the ratio of the emphysematous lung volume to the total lung volume using a density-mask technique. Pearson correlation analyses were performed to evaluate the relationships between these parameters. Multiple regression analysis was performed using forced expiratory volume in 1 second (FEV1) as the dependent parameter and the clinical and CT data as the independent parameters. FEV1 was significantly correlated with intercostal index (r = 0.57), latissimus index (r = 0.34), intercostal attenuation (r = 0.62), and latissimus attenuation (r = 0.38). Emphysema extent was significantly correlated with intercostal index (r = -0.36) and intercostal attenuation (r = -0.50). Multiple regression analysis showed that FEV1 was predicted by intercostal attenuation (B = 0.40), intercostal CSA (B = 0.23), emphysema extent (B = -0.23), and age (B = -0.21, R(2) = 0.64, P increase in intercostal fat are associated with worsening of COPD severity. Copyright © 2014 AUR. Published by Elsevier Inc. All rights reserved.

  16. Black hole accretion discs

    OpenAIRE

    Lasota, Jean-Pierre

    2015-01-01

    This is an introduction to models of accretion discs around black holes. After a presentation of the non-relativistic equations describing the structure and evolution of geometrically thin accretion discs we discuss their steady-state solutions and compare them to observation. Next we describe in detail the thermal-viscous disc instability model and its application to dwarf novae for which it was designed and its X-ray irradiated-disc version which explains the soft X--ray transients, i.e. ou...

  17. MHD of accretion-disk flows

    Science.gov (United States)

    Yankova, Krasimira

    2015-01-01

    Accretion is one of the most important problems of astrophysics concerning the transfer of matter and the transformation of energy into space. Process represents a falling of the substance on a cosmic object from the surrounding area and is a powerful gravitational mechanism for the production of radiation. Accretion disc effectively converts the mass of the substance by viscous friction and released potential energy transformed into radiation by particle collisions. Accretion onto compact object shows high energy efficiency and temporal variability in a broad class of observational data in all ranges. In the disks of these objects are developed a series instabilities and structures that govern the distribution of the energy. They are expressed in many variety non-stationary phenomena that we observe. That is why we propose generalized model of magnetized accretion disk with advection, which preserves the nonlinearity of the problem. We study interaction of the plasmas flow with the magnetic field, and how this affects the self-organizing disk. The aim of the work is to describe the accretion flow in detail, in his quality of the open astrophysical system, to investigate the evolution and to reveal the mechanisms of the structuring the disk-corona system for to interpret correctly the high energy behavior of such sources.

  18. Bondi accretion in early-type galaxies

    CERN Document Server

    Korol, V; Pellegrini, S

    2016-01-01

    Accretion onto central massive black holes in galaxies is often modelled with the Bondi solution. In this paper we study a generalization of the classical Bondi accretion theory, considering the additional effects of the gravitational potential of the host galaxy, and of electron scattering in the optically thin limit. We provide a general analysis of the bias in the estimates of the Bondi radius and mass accretion rate, when adopting as fiducial values for the density and temperature at infinity the values of these quantities measured at finite distance from the central black hole. We also give general formulae to compute the correction terms of the critical accretion parameter in relevant asymptotic regimes. A full analytical discussion is presented in the case of an Hernquist galaxy, when the problem reduces to the discussion of a cubic equation, therefore allowing for more than one critical point in the accretion structure. The results are useful for observational works (especially in the case of low-lumi...

  19. Optically-thick accretion discs with advection

    Institute of Scientific and Technical Information of China (English)

    陈林红; 吴枚; 尚仁成

    2002-01-01

    The structures of optically-thick accretion discs with radial advection have been investigated by the iteration and integration algorithms. The advective cooling term changes mostly the inner part of disc solution, and even results in an optically-thick advection-dominated accretion flow (ADAF). Three distinct branches-the outer Shakura-Sunyaev disc (SSD), the inner ADAF and the middle transition layer-are found for a super-Eddington disc. The SSD-ADAF transition radius can be estimated as 18(M/ME)RG where RG is the Schwarzschild radius, M is the mass accretion rate and ME is the Eddington accretion rate. SSD solutions calculated with the iteration and integration methods are identical, while ADAF solutions obtained by these two methods differ greatly. Detailed algorithms and their differences have been analysed. The iteration algorithm is not self-consistent, since it implies that the dimensionless advection factor ξ is invariant, but in the inner ADAF region the variation of ξ is not negligible. The integration algorithm is always effective for the whole region of an optically-thick disc if the accretion rate is no smaller than 10-4ME. For optically-thin discs, the validity of these two algorithms is different. We suggest that the integration method be employed to calculate the global solution of a disc model without assuming ξ to be a constant. We also discuss its application to the emergent continuum spectrum in order to explain observational facts.

  20. Visceral obesity, fat mass/muscle mass ratio and atherogenic dyslipidemia: cross-sectional study. Riobamba, Ecuador

    Directory of Open Access Journals (Sweden)

    Tomas Marcelo Nicolalde Cifuentes

    2015-10-01

    Full Text Available Introduction: The distribution and composition of fat mass is associated with different metabolic risks. The predominance of brown visceral fat is associated with risk factors for cardiovascular disease (CVD, such as: high triglycerides and apolipoprotein B, increased LDL cholesterol, ratio triglycerides/low HDL cholesterol elevated (atherogenic dyslipidemia indicator, insulin resistance, hyperinsulinemia and cardiovascular risk (CVR. Sarcopenia and obesity may act synergistically in functional and metabolic disorders. The aim of this study was to determine the relationship between visceral obesity, fat mass/muscular mass ratio and atherogenic dyslipidemia in adult individuals in order to determine the association pattern between these variables and set strategies for focused attention.Material and Methods: In a sample of 307 subjects of both sexes (21-71 years there was measured atherogenic dyslipidemia as the ratio of triglyceride/HDL cholesterol, visceral obesity measured by bio impedance as the relative score of visceral fat, and the ratio fat mass/lean mass.Results: A cluster analysis was performed to establish the structure of association between these variables with different risk groups. Three groups were identified: the first had visceral obesity with an average relative level of visceral fat of 13.6, the second group with an average of 8.9 and in the third group were placed individuals with the lowest visceral obesity score averaging 6.5. As for the fat mass/lean mas ratio the first two groups had a similar average of this index with a value of 1.56 and 1.69 respectively and the third group with the lowest average value of 1.3. Group 1 presented visceral obesity and impaired fat mass/lean mass ratio and had a high value of triglyceride/HDL ratio 4.1. Group 2 without visceral obesity and a deterioration in the relative fat mass/lean mass ratio had a triglyceride/HDL cholesterol of 3.6 and Group 3; not recorded visceral obesity or

  1. Physical activity as intervention for age-related loss of muscle mass and function

    DEFF Research Database (Denmark)

    Eriksen, Christian Skou; Garde, Ellen; Reislev, Nina Linde

    2016-01-01

    to maintain or even improve muscle power as well as physical function in older adults, but the optimal type of training for beneficial long-term training effects over several years is unknown. Moreover, the impact of muscle strength training on cognitive function and brain structure remains speculative......INTRODUCTION: Physical and cognitive function decline with age, accelerating during the 6th decade. Loss of muscle power (force×velocity product) is a dominant physical determinant for loss of functional ability, especially if the lower extremities are affected. Muscle strength training is known...... and cognitive function, mental well-being, health-related quality of life and brain morphology. METHODS AND ANALYSIS: The study includes 450 home-dwelling men and women (62-70 years). Participants are randomly allocated to (1) 1 year of supervised, centre-based heavy resistance training, (2) home-based moderate...

  2. Aliskiren Reduces Hepatic steatosis and Epididymal Fat Mass and Increases Skeletal Muscle Insulin Sensitivity in High-Fat Diet-Fed Mice

    National Research Council Canada - National Science Library

    Lee, Kuei-Chuan; Hsieh, Yun-Cheng; Yang, Ying-Ying; Chan, Che-Chang; Huang, Yi-Hsiang; Lin, Han-Chieh

    2016-01-01

    .... Aliskiren reduced systemic insulin resistance, hepatic steatosis, epididymal fat mass and increased gastrocnemius muscle glucose transporter type 4 levels with lower tissue angiotensin II levels in the HFD-fed mice...

  3. X-ray Photoevaporation-starved T Tauri Accretion

    CERN Document Server

    Drake, Jeremy J; Flaccomio, Ettore; Micela, Giusi

    2009-01-01

    X-ray luminosities of accreting T Tauri stars are observed to be systematically lower than those of non-accretors. There is as yet no widely accepted physical explanation for this effect, though it has been suggested that accretion somehow suppresses, disrupts or obscures coronal X-ray activity. Here, we suggest that the opposite might be the case: coronal X-rays modulate the accretion flow. We re-examine the X-ray luminosities of T Tauri stars in the Orion Nebula Cluster and find that not only are accreting stars systematically fainter, but that there is a correlation between mass accretion rate and stellar X-ray luminosity. We use the X-ray heated accretion disk models of Ercolano et al. to show that protoplanetary disk photoevaporative mass loss rates are strongly dependent on stellar X-ray luminosity and sufficiently high to be competitive with accretion rates. X-ray disk heating appears to offer a viable mechanism for modulating the gas accretion flow and could be at least partially responsible for the o...

  4. Estimation of Muscle Mass by Ultrasonography Differs between Observers and Life States of Models in Small Birds.

    Science.gov (United States)

    Royer-Boutin, Pascal; Cortés, Pablo A; Milbergue, Myriam; Petit, Magali; Vézina, François

    2015-01-01

    Ultrasonography has proven to be a valuable noninvasive method of measure of muscle size in birds, but validation of its use in birds as small as black-capped chickadees (Poecile atricapillus; 11 g) is scarce. The effect of observers and life state (dead or alive) of models used for calibration on measurement quality is also poorly documented. Using 31 dead and 22 live chickadees, linear regressions between ultrasound and dissection measurements of pectoral and thigh muscles were fitted and compared between five different observers. R(2) values varied greatly between observers and were generally weaker in live birds, ranging between 0.02 and 0.59, despite high repeatability of measurement. Using equations calculated from dead birds to estimate muscle mass of live birds yielded much higher measurement errors (9%-18%) than when using equations calculated from live birds (5%-8%). Our results suggest that with careful training and using only calibration from live birds, ultrasonography can be a useful but limited tool to estimate muscle size of birds as small as the black-capped chickadee.

  5. Treatment with a corticotrophin releasing factor 2 receptor agonist modulates skeletal muscle mass and force production in aged and chronically ill animals

    Directory of Open Access Journals (Sweden)

    Ferreira Leonardo F

    2011-01-01

    Full Text Available Abstract Background Muscle weakness is associated with a variety of chronic disorders such as emphysema (EMP and congestive heart failure (CHF as well as aging. Therapies to treat muscle weakness associated with chronic disease or aging are lacking. Corticotrophin releasing factor 2 receptor (CRF2R agonists have been shown to maintain skeletal muscle mass and force production in a variety of acute conditions that lead to skeletal muscle wasting. Hypothesis We hypothesize that treating animals with a CRF2R agonist will maintain skeletal muscle mass and force production in animals with chronic disease and in aged animals. Methods We utilized animal models of aging, CHF and EMP to evaluate the potential of CRF2R agonist treatment to maintain skeletal muscle mass and force production in aged animals and animals with CHF and EMP. Results In aged rats, we demonstrate that treatment with a CRF2R agonist for up to 3 months results in greater extensor digitorum longus (EDL force production, EDL mass, soleus mass and soleus force production compared to age matched untreated animals. In the hamster EMP model, we demonstrate that treatment with a CRF2R agonist for up to 5 months results in greater EDL force production in EMP hamsters when compared to vehicle treated EMP hamsters and greater EDL mass and force in normal hamsters when compared to vehicle treated normal hamsters. In the rat CHF model, we demonstrate that treatment with a CRF2R agonist for up to 3 months results in greater EDL and soleus muscle mass and force production in CHF rats and normal rats when compared to the corresponding vehicle treated animals. Conclusions These data demonstrate that the underlying physiological conditions associated with chronic diseases such as CHF and emphysema in addition to aging do not reduce the potential of CRF2R agonists to maintain skeletal muscle mass and force production.

  6. Mechanical muscle function and lean body mass during supervised strength training and testosterone therapy in aging men with low-normal testosterone levels

    DEFF Research Database (Denmark)

    Kvorning, Thue; Christensen, Louise L; Madsen, Klavs

    2013-01-01

    To examine the effect of strength training and testosterone therapy on mechanical muscle function and lean body mass (LBM) in aging men with low-normal testosterone levels in a randomized, double-blind, placebo-controlled 24-week study.......To examine the effect of strength training and testosterone therapy on mechanical muscle function and lean body mass (LBM) in aging men with low-normal testosterone levels in a randomized, double-blind, placebo-controlled 24-week study....

  7. Age-dependent changes in skeletal muscle mass and visceral fat area in Japanese adults from 40 to 79 years-of-age.

    Science.gov (United States)

    Yamada, Minoru; Moriguch, Yoko; Mitani, Takahiro; Aoyama, Tomoki; Arai, Hidenori

    2014-02-01

    The age-dependent loss of skeletal muscle mass is highly concerning in diverse aging populations. However, age-dependent changes in muscle mass and the visceral fat area have not been well documented in Asian populations. The aim of the present study was to evaluate the age-dependent changes in skeletal muscle mass and the visceral fat area in Japanese adults from 40 to 79 years-of-age. This was a cross-sectional study. Healthy men (n = 16,379) and women (n = 21,660) aged 40-79 years participated in the present study. The skeletal muscle mass and visceral fat area were measured in the study participants by bioelectrical impedance. The muscle mass data were converted into the skeletal muscle mass index (SMI) by dividing the weight by the height squared (kg/m(2)). The SMI showed an age-dependent decrease in both sexes. Between 40 and 79 years, the total SMI decreased by 10.8% in men and by 6.4% in women. The arm SMI decreased by 12.6% in men and 4.1% in women, and the leg SMI decreased by 10.1% in men and by 7.1% in women in the same period. In contrast, the visceral fat area showed an age-dependent increase in both sexes. The visceral fat area increased by 42.9% in men and by 65.3% in women. The multiple regression analysis showed that the SMI was negatively associated with visceral obesity in both sexes. In Japanese adults, sex-specific changes in skeletal muscle mass are more prominent in the arm than in the leg. Furthermore, the age-dependent increases in visceral adipose tissue might lead to loss of skeletal muscle mass. © 2014 Japan Geriatrics Society.

  8. The accretion of galaxies into groups and clusters

    CERN Document Server

    McGee, Sean L; Bower, Richard G; Font, Andreea S; McCarthy, Ian G

    2009-01-01

    We use the galaxy stellar mass and halo merger tree information from the semi-analytic model galaxy catalogue of Font et al. (2009) to examine the accretion of galaxies into a large sample of groups and clusters, covering a wide range in halo mass (10E12.9 to 10E15.3 Msun/h), and selected from each of four redshift epochs (z=0, 0.5, 1.0 and 1.5). We find that clusters at all examined redshifts have accreted a significant fraction of their final galaxy populations through galaxy groups. A 10E14.5 Msun/h mass cluster at z=0 has, on average, accreted ~ 40% of its galaxies (Mstellar > 10E9 Msun/h) from halos with masses greater than 10E13 Msun/h. Further, the galaxies which are accreted through groups are more massive, on average, than galaxies accreted through smaller halos or from the field population. We find that at a given epoch, the fraction of galaxies accreted from isolated environments is independent of the final cluster or group mass. In contrast, we find that observing a cluster of the same halo mass a...

  9. Dynamos in accretion discs

    OpenAIRE

    Brandenburg, A.; von Rekowski, B.

    2007-01-01

    It is argued that accretion discs in young stellar objects may have hot coronae that are heated by magnetic reconnection. This is a consequence of the magneto-rotational instability driving turbulence in the disc. Magnetic reconnection away from the midplane leads to heating of the corona which, in turn, contributes to driving disc winds.

  10. Viscosity in accretion discs

    Energy Technology Data Exchange (ETDEWEB)

    Katz, J.I.

    1980-01-01

    Both HerX-1 and SS433 may contain accretion disks slaved to a precessing companion star. If so, it is possible to bound the effective viscosity in these disks. The results, in terms of the disk parameter alpha, are lower bounds of 0.01 for HerX-1 and of 0.1 for SS433.

  11. The Solar Twin Planet Search. V. Close-in, low-mass planet candidates and evidence of planet accretion in the solar twin HIP 68468

    CERN Document Server

    Melendez, Jorge; Bean, Jacob L; Ramirez, Ivan; Asplund, Martin; Dreizler, Stefan; Yan, Hong-Liang; Shi, Jian-Rong; Lind, Karin; Ferraz-Mello, Sylvio; Galarza, Jhon Yana; Santos, Leonardo dos; Spina, Lorenzo; Maia, Marcelo Tucci; Alves-Brito, Alan; Monroe, TalaWanda; Casagrande, Luca

    2016-01-01

    [Methods]. We obtained high-precision radial velocities with HARPS on the ESO 3.6 m telescope and determined precise stellar elemental abundances (~0.01 dex) using MIKE spectra on the Magellan 6.5m telescope. [Results]. Our data indicate the presence of a planet with a minimum mass of 26 Earth masses around the solar twin HIP 68468. The planet is a super-Neptune, but unlike the distant Neptune in our solar system (30 AU), HIP 68468c is close-in, with a semi-major axis of 0.66 AU, similar to that of Venus. The data also suggest the presence of a super-Earth with a minimum mass of 2.9 Earth masses at 0.03 AU; if the planet is confirmed, it will be the fifth least massive radial velocity planet discovery to date and the first super-Earth around a solar twin. Both isochrones (5.9 Gyr) and the abundance ratio [Y/Mg] (6.4 Gyr) indicate an age of about 6 billion years. The star is enhanced in refractory elements when compared to the Sun, and the refractory enrichment is even stronger after corrections for Galactic c...

  12. Sports Mass Age Therapy on the Reduction of Delayed Onset Muscle Soreness of the Quadriceps Femoris

    Directory of Open Access Journals (Sweden)

    Boguszewski Dariusz

    2014-12-01

    Full Text Available Purpose. Massage therapy is one of most commonly applied treatments during athletic training. The aim of this study was to assess the effectiveness of sports massage therapy on reducing post-exercise quadriceps muscle soreness. Methods. A sample of 29 women aged 24-26 years was divided into an experimental group (n = 15 receiving classic sports massage therapy and a control group (n = 14 given no treatment. An exercise session consisting of five sets of deep squat jumps was administered after which lower limb power as assessed via the vertical jump test. Muscle soreness was assessed using the visual analogue scale (VAS and exercise intensity with the Borg Rating of Perceived Exertion Scale. Subsequent measurements of lower limb power and muscle soreness were performed 24, 48, 72 and 96 h after the exercise session. Differences between the measurements were assessed by the Friedman and least significant difference tests while between-group comparisons involved the Mann-Whitney U test. Results. The largest decrease in lower limb power was observed between the first measurement after the exercise session and 24 h later (p < 0.01. The smallest decrease in power was observed in the massage group. The highest levels of muscle soreness were noted 24 h post-exercise in the massage group and 48 h post-exercise in the control group. The experimental group showed a decrease in muscle soreness in each subsequent measurement, with the results close to zero on the VAS 96 h postexercise. Conclusions. Massage therapy quickened recovery and improved muscle efficiency post-exercise and may serve as an effective treatment of muscle soreness. The analgesic effect of massage suggests it should be widely applied in sport, physical therapy and rehabilitation.

  13. Androgen-mediated regulation of skeletal muscle protein balance.

    Science.gov (United States)

    Rossetti, Michael L; Steiner, Jennifer L; Gordon, Bradley S

    2017-02-22

    Androgens significantly alter muscle mass in part by shifting protein balance in favor of net protein accretion. During various atrophic conditions, the clinical impact of decreased production or bioavailability of androgens (termed hypogonadism) is important as a loss of muscle mass is intimately linked with survival outcome. While androgen replacement therapy increases muscle mass in part by restoring protein balance, this is not a comprehensive treatment option due to potential side effects. Therefore, an understanding of the mechanisms by which androgens alter protein balance is needed for the development of androgen-independent therapies. While the data in humans suggest androgens alter protein balance (both synthesis and breakdown) in the fasted metabolic state, a predominant molecular mechanism(s) behind this observation is still lacking. This failure is likely due in part to inconsistent experimental design between studies including failure to control nutrient/feeding status, the method of altering androgens, and the model systems utilized.

  14. Chaotic cold accretion on to black holes

    Science.gov (United States)

    Gaspari, M.; Ruszkowski, M.; Oh, S. Peng

    2013-07-01

    many systems, such as hot galactic haloes, groups and clusters. In this mode, the black hole can quickly react to the state of the entire host galaxy, leading to efficient self-regulated AGN feedback and the symbiotic Magorrian relation. Chaotic accretion can generate high-velocity clouds, likely leading to strong variations in the AGN luminosity, and the deflection or mass-loading of jets. During phases of overheating, the hot mode becomes the single channel of accretion, though strongly suppressed by turbulence. High-resolution data could determine the current mode of accretion: assuming quiescent feedback, the cold mode results in a quasi-flat-temperature core as opposed to the cuspy profile of the hot mode.

  15. Accretion discs trapped near corotation

    NARCIS (Netherlands)

    D'Angelo, C.R.; Spruit, H.C.

    2012-01-01

    We show that discs accreting on to the magnetosphere of a rotating star can end up in a trapped state, in which the inner edge of the disc stays near the corotation radius, even at low and varying accretion rates. The accretion in these trapped states can be steady or cyclic; we explore these states

  16. Formation of primordial supermassive stars by burst accretion

    CERN Document Server

    Sakurai, Y; Yoshida, N; Yorke, H W

    2015-01-01

    A promising formation channel of SMBHs at redshift 6 is the so-called DC model, which posits that a massive seed BH forms through gravitational collapse of a $\\sim 10^5~M_\\odot$ SMS. We study the evolution of such a SMS growing by rapid mass accretion. In particular, we examine the impact of time-dependent mass accretion of repeating burst and quiescent phases that are expected to occur with a self-gravitating circumstellar disk. We show that the stellar evolution with such episodic accretion differs qualitatively from that expected with a constant accretion rate, even if the mean accretion rate is the same. Unlike the case of constant mass accretion, whereby the star expands roughly following $R_* \\simeq 2.6 \\times 10^3 R_\\odot (M_*/100~M_\\odot)^{1/2}$, the protostar can substantially contract during the quiescent phases between accretion bursts. The stellar effective temperature and ionizing photon emissivity increase accordingly as the star contracts, which can cause strong ionizing feedback and halt the m...

  17. Age-related differences in lean mass, protein synthesis and skeletal muscle markers of proteolysis after bed rest and exercise rehabilitation

    DEFF Research Database (Denmark)

    Tanner, Ruth E; Brunker, Lucille B; Agergaard, Jakob

    2015-01-01

    Bed rest-induced muscle loss and impaired muscle recovery may contribute to age-related sarcopenia. It is unknown if there are age-related differences in muscle mass and muscle anabolic and catabolic responses to bed rest. A secondary objective was to determine if rehabilitation could reverse bed...... rest responses. Nine older and fourteen young adults participated in a 5-day bed rest challenge (BED REST). This was followed by 8 weeks of high intensity resistance exercise (REHAB). Leg lean mass (via dual-energy X-ray absorptiometry; DXA) and strength were determined. Muscle biopsies were collected...... during a constant stable isotope infusion in the postabsorptive state and after essential amino acid (EAA) ingestion on three occasions: before (PRE), after bed rest and after rehabilitation. Samples were assessed for protein synthesis, mTORC1 signalling, REDD1/2 expression and molecular markers related...

  18. BACK MUSCLES STRENGTH DEVELOPMENT BY MEANS OF INCREASE AND DECREASE OF EFFORT LOAD DURING GIANT SETS IN BODYBUILDING FOR MASSES

    Directory of Open Access Journals (Sweden)

    TIMNEA OLIVIA

    2013-01-01

    Full Text Available Abstract The aim of the study is to highlight methodological issues on the back muscle strength development by combining methodological procedures in masses bodybuilding.Methods. The study was conducted in three stages over a period of two months (March-April 2011, performing three workouts per week, monitoring the effective use of strength exercises to develop back muscles in the same muscle area by means of giant sets during workouts. In this context, we conducted a case study in "Tonik Fitness Club" in Bucharest, applied to two athletes of 28 and 34 years old. We recorded subjects’ evolutions during the training session, using statistical and mathematical method and graphical representation method.Results. The study content highlights the training programs depending on muscle zone and the specific methodological aspects, the weekly training program per muscle groups, the stages of study carrying out, the test and control trials applied in terms of anthropometric measurements and of back muscle strength development, and the application of the methodical procedure of effort load increase and decrease within the giant sets in a training micro-cycle.Discussion. The study focused on the training programs over two months, monitoring statistically the development of back muscle strength through the application of the procedure of effort load increase and decrease during giant sets in bodybuilding for masses. From the analysis of training programs content we noticed that three giant sets of exercises were used, performed in four series; each exercise within the giant sets was applied by means of the procedure of increasing and decreasing effort load. Study results emphasize the anthropometric measurement results: the study subjects have the age mean of 24.75, with a size of 175.2 cm and a weight of 83.75 kg at initial testing and a decrease by 2.12 kg in final testing. Regarding the chest perimeter, the inspiration is averaging 89.5 in initial

  19. The Solar Twin Planet Search. V. Close-in, low-mass planet candidates and evidence of planet accretion in the solar twin HIP 68468

    Science.gov (United States)

    Meléndez, Jorge; Bedell, Megan; Bean, Jacob L.; Ramírez, Iván; Asplund, Martin; Dreizler, Stefan; Yan, Hong-Liang; Shi, Jian-Rong; Lind, Karin; Ferraz-Mello, Sylvio; Galarza, Jhon Yana; dos Santos, Leonardo; Spina, Lorenzo; Maia, Marcelo Tucci; Alves-Brito, Alan; Monroe, TalaWanda; Casagrande, Luca

    2017-01-01

    Context. More than two thousand exoplanets have been discovered to date. Of these, only a small fraction have been detected around solar twins, which are key stars because we can obtain accurate elemental abundances especially for them, which is crucial for studying the planet-star chemical connection with the highest precision. Aims: We aim to use solar twins to characterise the relationship between planet architecture and stellar chemical composition. Methods: We obtained high-precision (1 m s-1) radial velocities with the HARPS spectrograph on the ESO 3.6 m telescope at La Silla Observatory and determined precise stellar elemental abundances ( 0.01 dex) using spectra obtained with the MIKE spectrograph on the Magellan 6.5 m telescope. Results: Our data indicate the presence of a planet with a minimum mass of 26 ± 4 Earth masses around the solar twin HIP 68468. The planet is more massive than Neptune (17 Earth masses), but unlike the distant Neptune in our solar system (30 AU), HIP 68468c is close-in, with a semi-major axis of 0.66 AU, similar to that of Venus. The data also suggest the presence of a super-Earth with a minimum mass of 2.9 ± 0.8 Earth masses at 0.03 AU; if the planet is confirmed, it will be the fifth least massive radial velocity planet candidate discovery to date and the first super-Earth around a solar twin. Both isochrones (5.9 ± 0.4 Gyr) and the abundance ratio [Y/Mg] (6.4 ± 0.8 Gyr) indicate an age of about 6 billion years. The star is enhanced in refractory elements when compared to the Sun, and the refractory enrichment is even stronger after corrections for Galactic chemical evolution. We determined a nonlocal thermodynamic equilibrium Li abundance of 1.52 ± 0.03 dex, which is four times higher than what would be expected for the age of HIP 68468. The older age is also supported by the low log () (-5.05) and low jitter (existence of the planets that are indicated by our data and to better constrain the nature of the planetary system

  20. Metallomics investigations on potential binding partners of methylmercury in tuna fish muscle tissue using complementary mass spectrometric techniques.

    Science.gov (United States)

    Kutscher, Daniel J; Sanz-Medel, Alfredo; Bettmer, Jörg

    2012-08-01

    In this study, the binding behaviour of methylmercury (MeHg(+)) towards proteins is investigated. Free sulfhydryl groups in cysteine residues are known to be the most likely binding partners, due to the high affinity of mercury to sulphur. However, detailed knowledge about discrete binding sites in living organisms has been so far scarce. A metallomics approach using different methods like size-exclusion chromatography (SEC) and liquid chromatography (LC) coupled to inductively coupled plasma-mass spectrometry (ICP-MS) as well as complementary mass spectrometric techniques (electrospray ionisation-tandem mass spectrometry, ESI-MS/MS) are combined to sequence and identify possible target proteins or peptides after enzymatic digestion. Potential targets for MeHg(+) in tuna fish muscle tissue are investigated using the certified reference material CRM464 as a model tissue. Different extraction procedures appropriate for the extraction of proteins are evaluated for their efficiency using isotope dilution analysis for the determination of total Hg in the extracts. Due to the high chemical stability of the mercury-sulphur bond, the bioconjugate can be quantitatively extracted with a combination of tris(hydroxymethyl)aminomethane (TRIS) and sodium dodecyl sulphate (SDS). Using different separation techniques such as SEC and SDS-polyacrylamide gel electrophoresis (SDS-PAGE) it can be shown that major binding occurs to a high-molecular weight protein (M(w) > 200 kDa). A potential target protein, skeletal muscle myosin heavy chain, could be identified after tryptic digestion and capillary LC-ESI-MS/MS.

  1. Dexamethasone and BCAA Failed to Modulate Muscle Mass and mTOR Signaling in GH-Deficient Rats.

    Directory of Open Access Journals (Sweden)

    Hikaru Nishida

    Full Text Available Branched-chain amino acids (BCAAs and IGF-I, the secretion of which is stimulated by growth hormone (GH, prevent muscle atrophy. mTOR plays a pivotal role in the protective actions of BCAA and IGF-1. The pathway by which BCAA activates mTOR is different from that of IGF-1, which suggests that BCAA and GH work independently. We tried to examine whether BCAA exerts a protective effect against dexamethasone (Dex-induced muscle atrophy independently of GH using GH-deficient spontaneous dwarf rats (SDRs. Unexpectedly, Dex did not induce muscle atrophy assessed by the measurement of cross-sectional area (CSA of the muscle fibers and did not increase atrogin-1, MuRF1 and REDD1 expressions, which are activated during protein degradation. Glucocorticoid (GR mRNA levels were higher in SDRs compared to GH-treated SDRs, indicating that the low expression of GR is not the reason of the defect of Dex's action in SDRs. BCAA did not stimulate the phosphorylation of p70S6K or 4E-BP1, which stimulate protein synthesis. BCAA did not decrease the mRNA level of atrogin-1 or MuRF1. These findings suggested that Dex failed to modulate muscle mass and that BCAA was unable to activate mTOR in SDRs because these phosphorylations of p70S6K and 4E-BP1 and the reductions of these mRNAs are regulated by mTOR. In contrast, after GH supplementation, these responses to Dex were normalized and muscle fiber CSA was decreased by Dex. BCAA prevented the Dex-induced decrease in CSA. BCAA increased the phosphorylation of p70S6K and decreased the Dex-induced elevations of atrogin-1 and Bnip3 mRNAs. However, the amount of mTORC1 components including mTOR was not decreased in the SDRs compared to the normal rats. These findings suggest that GH increases mTORC1 activity but not its content to recover the action of BCAA in SDRs and that GH is required for actions of Dex and BCAA in muscles.

  2. Dexamethasone and BCAA Failed to Modulate Muscle Mass and mTOR Signaling in GH-Deficient Rats.

    Science.gov (United States)

    Nishida, Hikaru; Ikegami, Ayaka; Kaneko, Chiaki; Kakuma, Hitomi; Nishi, Hisano; Tanaka, Noriko; Aoyama, Michiko; Usami, Makoto; Okimura, Yasuhiko

    2015-01-01

    Branched-chain amino acids (BCAAs) and IGF-I, the secretion of which is stimulated by growth hormone (GH), prevent muscle atrophy. mTOR plays a pivotal role in the protective actions of BCAA and IGF-1. The pathway by which BCAA activates mTOR is different from that of IGF-1, which suggests that BCAA and GH work independently. We tried to examine whether BCAA exerts a protective effect against dexamethasone (Dex)-induced muscle atrophy independently of GH using GH-deficient spontaneous dwarf rats (SDRs). Unexpectedly, Dex did not induce muscle atrophy assessed by the measurement of cross-sectional area (CSA) of the muscle fibers and did not increase atrogin-1, MuRF1 and REDD1 expressions, which are activated during protein degradation. Glucocorticoid (GR) mRNA levels were higher in SDRs compared to GH-treated SDRs, indicating that the low expression of GR is not the reason of the defect of Dex's action in SDRs. BCAA did not stimulate the phosphorylation of p70S6K or 4E-BP1, which stimulate protein synthesis. BCAA did not decrease the mRNA level of atrogin-1 or MuRF1. These findings suggested that Dex failed to modulate muscle mass and that BCAA was unable to activate mTOR in SDRs because these phosphorylations of p70S6K and 4E-BP1 and the reductions of these mRNAs are regulated by mTOR. In contrast, after GH supplementation, these responses to Dex were normalized and muscle fiber CSA was decreased by Dex. BCAA prevented the Dex-induced decrease in CSA. BCAA increased the phosphorylation of p70S6K and decreased the Dex-induced elevations of atrogin-1 and Bnip3 mRNAs. However, the amount of mTORC1 components including mTOR was not decreased in the SDRs compared to the normal rats. These findings suggest that GH increases mTORC1 activity but not its content to recover the action of BCAA in SDRs and that GH is required for actions of Dex and BCAA in muscles.

  3. Spherical Accretion in a Uniformly Expanding Universe

    Science.gov (United States)

    Colpi, Monica; Shapiro, Stuart L.; Wasserman, Ira

    1996-10-01

    We consider spherically symmetric accretion of material from an initially homogeneous, uniformly expanding medium onto a Newtonian point mass M. The gas is assumed to evolve adiabatically with a constant adiabatic index F, which we vary over the range Γ ɛ [1, 5/3]. We use a one-dimensional Lagrangian code to follow the spherical infall of material as a function of time. Outflowing shells gravitationally bound to the point mass fall back, giving rise to a inflow rate that, after a rapid rise, declines as a power law in time. If there were no outflow initially, Bondi accretion would result, with a characteristic accretion time-scale ta,0. For gas initially expanding at a uniform rate, with a radial velocity U = R/t0 at radius R, the behavior of the flow at all subsequent times is determined by ta,0/t0. If ta,0/t0 ≫ 1, the gas has no time to respond to pressure forces, so the fluid motion is nearly collisionless. In this case, only loosely bound shells are influenced by pressure gradients and are pushed outward. The late-time evolution of the mass accretion rate Mdot is close to the result for pure dust, and we develop a semianalytic model that accurately accounts for the small effect of pressure gradients in this limit. In the opposite regime, ta,0/t0 ≪ 1, pressure forces significantly affect the motion of the gas. At sufficiently early times, t ≤ ttr, the flow evolved along a sequence of quasi-stationary, Bondi-like states, with a time-dependent Mdot determined by the slowly varying gas density at large distances. However, at later times, t ≥ ttr, the fluid flow enters a dustllke regime; ttr is the time when the instantaneous Bondi accretion radius reaches the marginally bound radius. The transition time ttr depends sensitively on ta,0/t0 for a given Γ and can greatly exceed t0. We show that there exists a critical value Γ = 11/9, below which the transition from fluid to ballistic motion disappears. As one application of our calculations, we consider the

  4. Evolution and precession of accretion disk in tidal disruption events

    Directory of Open Access Journals (Sweden)

    Matzner C.D.

    2012-12-01

    Full Text Available In a supermassive black hole (BH tidal disruption event (TDE, the tidally disrupted star feeds the BH via an accretion disk. Most often it is assumed that the accretion rate history, hence the emission light curve, tracks the rate at which new debris mass falls back onto the disk, notably the t−5/3 power law. But this is not the case when the disk evolution due to viscous spreading - the driving force for accretion - is carefully considered. We construct a simple analytical model that comprehensively describes the accretion rate history across 4 different phases of the disk evolution, in the presence of mass fallback and disk wind loss. Accretion rate evolves differently in those phases which are governed by how the disk heat energy is carried away, early on by advection and later by radiation. The accretion rate can decline as steeply as t−5/3 only if copious disk wind loss is present during the early advection-cooled phase. Later, the accretion rate history is t−8/7 or shallower. These have great implications on the TDE flare light curve. A TDE accretion disk is most likely misaligned with the equatorial plane of the spinning BH. Moreover, in the TDE the accretion rate is super- or near-Eddington thus the disk is geometrically thick, for which case the BH’s frame dragging effect may cause the disk precess as a solid body, which may manifest itself as quasi-periodic signal in the TDE light curve. Our disk evolution model predicts the disk precession period increases with time, typically as ∝ t. The results are applied to the recently jetted TDE flare Swift transient J1644 + 57 which shows numerous, quasi-periodic dips in its long-term X-ray light curve. As the current TDE sample increases, the identification of the disk precession signature provides a unique way of measuring BH spin and studying BH accretion physics.

  5. Confirmatory analysis of steroids in muscle using liquid chromatography-tandem mass spectrometry

    DEFF Research Database (Denmark)

    Pedersen, Mikael; Andersen, Jens Hinge

    2011-01-01

    A method is described for screening and confirmation of synthetic and endogenous steroids in muscle tissue. The method is sensitive, selective, and rapid and the consumption of organic solvents is low, compared to previously published methods. The procedure involves hydrolysis, defattening with h...

  6. Dietary proteins and amino acids in the control of the muscle mass during immobilization and aging: role of the MPS response.

    Science.gov (United States)

    Cholewa, Jason M; Dardevet, Dominique; Lima-Soares, Fernanda; de Araújo Pessôa, Kassiana; Oliveira, Paulo Henrique; Dos Santos Pinho, João Ricardo; Nicastro, Humberto; Xia, Zhi; Cabido, Christian Emmanuel Torres; Zanchi, Nelo Eidy

    2017-05-01

    Dietary proteins/essential amino acids (EAAs) are nutrients with anabolic properties that may increase muscle mass or attenuate muscle loss during immobilization and aging via the stimulation of muscle protein synthesis (MPS). An EAA's anabolic threshold, capable to maximize the stimulation of MPS has been hypothesized, but during certain conditions associated with muscle loss, this anabolic threshold seems to increase which reduces the efficacy of dietary EAAs to stimulate MPS. Preliminary studies have demonstrated that acute ingestion of dietary proteins/EAA (with a sufficient amount of leucine) was capable to restore the postprandial MPS during bed rest, immobilization or aging; however, whether these improvements translate into chronic increases (or attenuates loss) of muscle mass is equivocal. For example, although free leucine supplementation acutely increases MPS and muscle mass in some chronic studies, other studies have reported no increases in muscle mass following chronic leucine supplementation. In contrast, chronically increasing leucine intake via the consumption of an overall increase in dietary protein appears to be the most effective dietary intervention toward increasing or attenuating lean mass during aging; however, more research investigating the optimal dose and timing of protein ingestion is necessary. Several studies have demonstrated that decreases in postprandial MPS as a result of increased circulating oxidative and inflammatory are more responsible than muscle protein breakdown for the decreases in muscle mass during disuse and health aging. Therefore, nutritional interventions that reduce oxidation or inflammation in conjunction with higher protein intakes that overcome the anabolic resistance may enhance the MPS response to feeding and either increase muscle mass or attenuate loss. In preliminary studies, antioxidant vitamins and amino acids with antioxidant or anti-inflammatory properties show potential to restore the anabolic

  7. Studies of the Origin of High-Frequency Quasi-Periodic Oscillations of Mass Accreting Black Holes in X-ray Binaries with Next-Generation X-ray Telescopes

    CERN Document Server

    Beheshtipour, Banafsheh; Krawczynski, Henric

    2016-01-01

    Observations with RXTE (Rossi X-ray Timing Explorer) revealed the presence of High Frequency Quasi-Periodic Oscillations (HFQPOs) of the X-ray flux from several accreting stellar mass Black Holes. HFQPOs (and their counterparts at lower frequencies) may allow us to study general relativity in the strong gravity regime. However, the observational evidence today does not yet allow us to distinguish between different HFQPO models. In this paper we use a general relativistic ray-tracing code to investigate X-ray timing-spectroscopy and polarization properties of HFQPOs in the orbiting Hotspot model. We study observational signatures for the particular case of the 166 Hz quasi-periodic oscillation (QPO) in the galactic binary GRS 1915+105. We conclude with a discussion of the observability of spectral signatures with a timing-spectroscopy experiment like the LOFT (Large Observatory for X-ray Timing) and polarization signatures with space-borne X-ray polarimeters such as IXPE (Imaging X-ray Polarimetry Explorer), P...

  8. The environmental dependence of gas accretion onto galaxies: quenching satellites through starvation

    CERN Document Server

    van de Voort, Freeke; Bower, Richard G; Correa, Camila A; Crain, Robert A; Schaye, Joop; Theuns, Tom

    2016-01-01

    Galaxies that have fallen into massive haloes may no longer be able to accrete gas from their surroundings, a process referred to as 'starvation' or 'strangulation' of satellites. We study the environmental dependence of gas accretion onto galaxies using the cosmological, hydrodynamical EAGLE simulation. We quantify the dependence of gas accretion on stellar mass, redshift, and environment, using halo mass and galaxy overdensity as environmental indicators. We find a strong suppression, by many orders of magnitude, of the gas accretion rate in dense environments, primarily for satellite galaxies. This suppression becomes stronger at lower redshift. However, the scatter in accretion rates is very large for satellites. This is (at least in part) due to the variation in halocentric radius, since gas accretion is more suppressed at smaller radii. Central galaxies are influenced less strongly by their environment and exhibit less scatter in their gas accretion rates. The star formation rates of both centrals and s...

  9. Accretion Discs in Blazars

    OpenAIRE

    Jolley, E. J. D.; Kuncic, Z.; Bicknell, G. V.; Wagner, S.(Max-Planck-Institut für Kernphysik, 69117, Heidelberg, Germany)

    2009-01-01

    The characteristic properties of blazars (rapid variability, strong polarization, high brightness) are widely attributed to a powerful relativistic jet oriented close to our line of sight. Despite the spectral energy distributions (SEDs) being strongly jet-dominated, a "big blue bump" has been recently detected in sources known as flat spectrum radio quasars (FSRQs). These new data provide a unique opportunity to observationally test coupled jet-disc accretion models in these extreme sources....

  10. An ultratriathlon leads to a decrease of body fat and skeletal muscle mass--the Triple Iron Triathlon Austria 2006.

    Science.gov (United States)

    Knechtle, Beat; Beat, Knechtle; Duff, Brida; Brida, Duff; Amtmann, Gerhard; Gerhard, Amtmann; Kohler, Götz; Götz, Kohler

    2008-01-01

    We investigated the effects on body composition in triathletes at the Triple Iron Triathlon Austria in 2006, where athletes had to perform 11.6 km swimming, 540 km cycling, and 126.6 km running within 58 h. In 16 male triathletes, body mass (BM), skinfold thicknesses, and circumferences of extremities were measured before and after the competition in order to calculate body mass index (BMI), percent body fat (%BF), fat mass (FM), and skeletal muscle mass (SM). Body mass, BMI, %BF, FM, and SM decreased statistically significantly (p 0.05, r(2)= 0.00) nor with the decrease of SM (p> 0.05, r(2)= 0.06). There is no association between total race time and the loss of BM (r(2) = 0.06), %BF (r(2) = 0.10), and SM (r2 = 0.11). No significant correlation (p > 0.05, r(2)= 0.43) was found between the initial SM and loss of SM.

  11. Formation of redbacks via accretion induced collapse

    CERN Document Server

    Smedley, Sarah L; Ferrario, Lilia; Wickramasinghe, Dayal T

    2014-01-01

    We examine the growing class of binary millisecond pulsars known as redbacks. In these systems the pulsar's companion has a mass between 0.1 and about 0.5 solar masses in an orbital period of less than 1.5 days. All show extended radio eclipses associated with circumbinary material. They do not lie on the period-companion mass relation expected from the canonical intermediate-mass X-ray binary evolution in which the companion filled its Roche lobe as a red giant and has now lost its envelope and cooled as a white dwarf. The redbacks lie closer to, but usually at higher period than, the period-companion mass relation followed by cataclysmic variables and low-mass X-ray binaries. In order to turn on as a pulsar mass accretion on to a neutron star must be sufficiently weak, considerably weaker than expected in systems with low-mass main-sequence companions driven together by magnetic braking or gravitational radiation. If a neutron star is formed by accretion induced collapse of a white dwarf as it approaches th...

  12. Different Levels of Eccentric Resistance during Eight Weeks of Training Affect Muscle Strength and Lean Tissue Mass

    Science.gov (United States)

    English, K. L.; Loehr, J. A.; Lee, S. M. C.; Laughlin, M. S.; Hagan, R. D.

    2008-01-01

    Coupling concentric and eccentric muscle contractions appears to be important in the development of muscle strength and hypertrophy. The interim Resistive Exercise Device (iRED) currently used aboard the International Space Station does not seem to be as effective as free weight training in ambulatory subjects and has not completely protected against muscular deconditioning due to space flight. The lack of protection during space flight could be caused by iRED's proportionally lower eccentric resistance (60-70%) compared to concentric resistance. PURPOSE: To determine the effects of 8 wks of lower body resistive exercise training using five levels of eccentric resistance on muscle strength and lean tissue mass. METHODS: Forty untrained males (34.9 +/- 7 yrs, 80.9 +/- 9.8 kg, 178.2 +/- 7.1 cm; mean +/- SD) completed three 1-repetition maximum (1-RM) strength tests for both the supine leg press (LP) and supine heel raise (HR) prior to training; subjects were matched for LP strength and randomly assigned to one of five training groups. Concentric load (% 1-RM) was constant across groups during training, but each group trained with different levels of eccentric load (0%, 33%, 66%, 100%, or 138% of concentric). Subjects trained 3 d / wk for 8 wks using a periodized program for LP and HR based on percentages of the highest pre-training 1-RM. LP and HR 1-RM and leg lean mass (LLM; assessed by DEXA) were measured pre- and post-training. A two-way ANOVA was used to analyze all dependent measures. Tukey's post hoc tests were used to test significant main effects. Within group pre- to post-training changes were compared using paired t-tests with a Bonferroni adjustment. Statistical significance was set a priori at p 0.05. All data are expressed as mean +/- SE. RESULTS: LP 1-RM strength increased significantly in all groups pre- to post-training. The 138% group increase (20.1 +/- 3.7%) was significantly greater than the 0% (7.9 +/- 2.8%), 33% (7.7 +/- 4.6%), and 66% (7.5 +/- 4

  13. Different Levels of Eccentric Resistance during Eight Weeks of Training Affect Muscle Strength and Lean Tissue Mass

    Science.gov (United States)

    English, K. L.; Loehr, J. A.; Lee, S. M. C.; Laughlin, M. S.; Hagan, R. D.

    2008-01-01

    Coupling concentric and eccentric muscle contractions appears to be important in the development of muscle strength and hypertrophy. The interim Resistive Exercise Device (iRED) currently used aboard the International Space Station does not seem to be as effective as free weight training in ambulatory subjects and has not completely protected against muscular deconditioning due to space flight. The lack of protection during space flight could be caused by iRED's proportionally lower eccentric resistance (60-70%) compared to concentric resistance. PURPOSE: To determine the effects of 8 wks of lower body resistive exercise training using five levels of eccentric resistance on muscle strength and lean tissue mass. METHODS: Forty untrained males (34.9 +/- 7 yrs, 80.9 +/- 9.8 kg, 178.2 +/- 7.1 cm; mean +/- SD) completed three 1-repetition maximum (1-RM) strength tests for both the supine leg press (LP) and supine heel raise (HR) prior to training; subjects were matched for LP strength and randomly assigned to one of five training groups. Concentric load (% 1-RM) was constant across groups during training, but each group trained with different levels of eccentric load (0%, 33%, 66%, 100%, or 138% of concentric). Subjects trained 3 d / wk for 8 wks using a periodized program for LP and HR based on percentages of the highest pre-training 1-RM. LP and HR 1-RM and leg lean mass (LLM; assessed by DEXA) were measured pre- and post-training. A two-way ANOVA was used to analyze all dependent measures. Tukey's post hoc tests were used to test significant main effects. Within group pre- to post-training changes were compared using paired t-tests with a Bonferroni adjustment. Statistical significance was set a priori at p 0.05. All data are expressed as mean +/- SE. RESULTS: LP 1-RM strength increased significantly in all groups pre- to post-training. The 138% group increase (20.1 +/- 3.7%) was significantly greater than the 0% (7.9 +/- 2.8%), 33% (7.7 +/- 4.6%), and 66% (7.5 +/- 4

  14. Effect of estrogenic compounds (estrogen or phytoestrogens) combined with exercise on bone and muscle mass in older individuals.

    Science.gov (United States)

    Chilibeck, Philip D; Cornish, Stephen M

    2008-02-01

    Exercise has a beneficial effect on bone, possibly by stimulating estrogen receptor alpha. Because estrogen up-regulates this receptor, estrogen therapy combined with exercise training may be optimal for increasing bone mineral density. Studies combining estrogen therapy and exercise training in postmenopausal women show mixed results, but indicate that the combination of interventions may be more effective for increasing bone mass than either intervention alone. Plant-like estrogens (i.e phytoestrogens such as soy isoflavones) may act as weak estrogen agonists or antagonists, have small beneficial effects on bone, and may interact with exercise for increasing bone mineral density. Phytoestrogen derived from flaxseed (flax lignans) has not been evaluated as extensively as soy isoflavones and thus its effect on bone is difficult to determine. Estrogen or soy isoflavones given to postmenopausal women results in a small increase in lean tissue mass that may be mediated through estrogen receptor alpha on muscle or through decreased inflammation.

  15. Phantom Energy Accretion by a Stringy Charged Black Hole

    Institute of Scientific and Technical Information of China (English)

    M.Sharif; G.Abbas

    2012-01-01

    We investigate the dynamical behavior of phantom energy near a stringy magnetically charged black hole. For this purpose, we derive equations of motion for steady-state spherically symmetric Row of phantom energy onto the stringy magnetically charged black hole. It is found that phantom energy accreting onto a black hole decreases its mass. Further, the location of the critical points of accretion is explored, which yields a mass to charge ratio. This ratio implies that accretion process cannot transform a black hole into an extremal black hole or a naked singularity, hence cosmic censorship hypothesis remains valid here.%We investigate the dynamical behavior of phantom energy near a stringy magnetically charged black hole.For this purpose,we derive equations of motion for steady-state spherically symmetric flow of phantom energy onto the stringy magnetically charged black hole.It is found that phantom energy accreting onto a black hole decreases its mass.Further,the location of the critical points of accretion is explored,which yields a mass to charge ratio.This ratio implies that accretion process cannot transform a black hole into an extremal black hole or a naked singularity,hence cosmic censorship hypothesis remains valid here.

  16. Compositional evolution during rocky protoplanet accretion

    CERN Document Server

    Carter, Philip J; Elliott, Tim; Walter, Michael J; Stewart, Sarah T

    2015-01-01

    The Earth appears non-chondritic in its abundances of refractory lithophile elements, posing a significant problem for our understanding of its formation and evolution. It has been suggested that this non-chondritic composition may be explained by collisional erosion of differentiated planetesimals of originally chondritic composition. In this work, we present N-body simulations of terrestrial planet formation that track the growth of planetary embryos from planetesimals. We simulate evolution through the runaway and oligarchic growth phases under the Grand Tack model and in the absence of giant planets. These simulations include a state-of-the-art collision model which allows multiple collision outcomes, such as accretion, erosion, and bouncing events, that enables tracking of the evolving core mass fraction of accreting planetesimals. We show that the embryos grown during this intermediate stage of planet formation exhibit a range of core mass fractions, and that with significant dynamical excitation, enoug...

  17. Forced accretion in stochastically fed AGN and quasars

    CERN Document Server

    Nayakshin, Sergei

    2007-01-01

    Steady state accretion discs larger than ~ 0.01-0.1 pc are known to be gravitationally unstable for the accretion rates needed to explain super-massive black hole (SMBH) activity. We propose that SMBH are fed by a succession of mass deposition events with randomly directed angular momenta. Because of incomplete angular momentum cancellation a warped accretion disc forms in the inner few parsec. The orientation of the disc performs a random walk. Deposition of new material promotes SMBH accretion at rates much faster than viscous. Observational implications of this picture include: (i) lighter accretion discs that can fuel AGN and quasars and yet avoid star formation at R >> 0.1 pc; (ii) star formation inside the disc is not a function of mass accretion rate only. It can take place at high or low accretion rates, e.g., when too few clouds arrive in the inner region. An example of this might be the central parsec of our Galaxy. (iii) The discs can form Compton-thick obscuring structures of ~ parsec size as requ...

  18. Skeletal Muscle Depletion Predicts the Prognosis of Patients with Advanced Pancreatic Cancer Undergoing Palliative Chemotherapy, Independent of Body Mass Index.

    Directory of Open Access Journals (Sweden)

    Younak Choi

    Full Text Available Body composition has emerged as a prognostic factor in cancer patients. We investigated whether sarcopenia at diagnosis and loss of skeletal muscle during palliative chemotherapy were associated with survival in patients with pancreatic cancer.We retrospectively reviewed the clinical outcomes of pancreatic cancer patients receiving palliative chemotherapy between 2003 and 2010. The cross-sectional area of skeletal muscle at L3 by computed tomography was analyzed with Rapidia 3D software. We defined sarcopenia as a skeletal muscle index (SMI< 42.2 cm2/m2 (male and < 33.9 cm2/m2 (female using ROC curve.Among 484 patients, 103 (21.3% patients were sarcopenic at diagnosis. Decrease in SMI during chemotherapy was observed in 156 (60.9% male and 65 (40.6% female patients. Decrease in body mass index (BMI was observed in 149 patients (37.3%, with no gender difference. By multivariate analysis, sarcopenia (P< 0.001, decreasedBMI and SMI during chemotherapy (P = 0.002, P = 0.004, respectively were poor prognostic factors for overall survival (OS. While the OS of male patients was affected with sarcopenia (P< 0.001 and decreased SMI (P = 0.001, the OS of female patients was influenced with overweight at diagnosis (P = 0.006, decreased BMI (P = 0.032 and decreased SMI (P = 0.014. Particularly, while the change of BMI during chemotherapy did not have impact on OS within the patients with maintained SMI (P = 0.750, decrease in SMI was associated with poor OS within the patients with maintained BMI (HR 1.502; P = 0.002.Sarcopenia at diagnosis and depletion of skeletal muscle, independent of BMI change, during chemotherapy were poor prognostic factors in advanced pancreatic cancer.

  19. Accretion onto a moving Reissner-Nordström black hole

    Science.gov (United States)

    Jiao, Lei; Yang, Rongjia

    2017-09-01

    We obtain an analytic solution for accretion of a gaseous medium with a adiabatic equation of state (P=ρ) onto a Reissner-Nordström black hole which moves at a constant velocity through the medium. We obtain the specific expression for each component of the velocity and present the mass accretion rate which depends on the mass and the electric charge. The result we obtained may be helpful to understand the physical mechanism of accretion onto a moving black hole.