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Sample records for muscle mass accretion

  1. Phenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female mice.

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    Mandy Sawitzky

    Full Text Available We have investigated molecular mechanisms for muscle mass accretion in a non-inbred mouse model (DU6P mice characterized by extreme muscle mass. This extreme muscle mass was developed during 138 generations of phenotype selection for high protein content. Due to the repeated trait selection a complex setting of different mechanisms was expected to be enriched during the selection experiment. In muscle from 29-week female DU6P mice we have identified robust increases of protein kinase B activation (AKT, Ser-473, up to 2-fold if compared to 11- and 54-week DU6P mice or controls. While a number of accepted effectors of AKT activation, including IGF-I, IGF-II, insulin/IGF-receptor, myostatin or integrin-linked kinase (ILK, were not correlated with this increase, phosphatase and tensin homologue deleted on chromosome 10 (PTEN was down-regulated in 29-week female DU6P mice. In addition, higher levels of PTEN phosphorylation were found identifying a second mechanism of PTEN inhibition. Inhibition of PTEN and activation of AKT correlated with specific activation of p70S6 kinase and ribosomal protein S6, reduced phosphorylation of eukaryotic initiation factor 2α (eIF2α and higher rates of protein synthesis in 29-week female DU6P mice. On the other hand, AKT activation also translated into specific inactivation of glycogen synthase kinase 3ß (GSK3ß and an increase of muscular glycogen. In muscles from 29-week female DU6P mice a significant increase of protein/DNA was identified, which was not due to a reduction of protein breakdown or to specific increases of translation initiation. Instead our data support the conclusion that a higher rate of protein translation is contributing to the higher muscle mass in mid-aged female DU6P mice. Our results further reveal coevolution of high protein and high glycogen content during the selection experiment and identify PTEN as gate keeper for muscle mass in mid-aged female DU6P mice.

  2. Focused Wind Mass Accretion in Mira AB

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    Karovska, Margarita; de Val-Borro, M.; Hack, W.; Raymond, J.; Sasselov, D.; Lee, N. P.

    2011-05-01

    At a distance of about only 100pc, Mira AB is the nearest symbiotic system containing an Asymptotic Giant Branch (AGB) star (Mira A), and a compact accreting companion (Mira B) at about 0.5" from Mira A. Symbiotic systems are interacting binaries with a key evolutionary importance as potential progenitors of a fraction of asymmetric Planetary Nebulae, and SN type Ia, cosmological distance indicators. The region of interaction has been studied using high-angular resolution, multiwavelength observations ranging from radio to X-ray wavelengths. Our results, including high-angular resolution Chandra imaging, show a "bridge" between Mira A and Mira B, indicating gravitational focusing of the Mira A wind, whereby components exchange matter directly in addition to the wind accretion. We carried out a study using 2-D hydrodynamical models of focused wind mass accretion to determine the region of wind acceleration and the characteristics of the accretion in Mira AB. We highlight some of our results and discuss the impact on our understanding of accretion processes in symbiotic systems and other detached and semidetached interacting systems.

  3. Accretion onto stellar mass black holes

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    Deegan, Patrick

    2009-12-01

    I present work on the accretion onto stellar mass black holes in several scenarios. Due to dynamical friction stellar mass black holes are expected to form high density cusps in the inner parsec of our Galaxy. These compact remnants may be accreting cold dense gas present there, and give rise to potentially observable X-ray emission. I build a simple but detailed time-dependent model of such emission. Future observations of the distribution and orbits of the gas in the inner parsec of Sgr A* will put tighter constraints on the cusp of compact remnants. GRS 1915+105 is an LMXB, whose large orbital period implies a very large accretion disc and explains the extraordinary duration of its current outburst. I present smoothed particle hydrodynamic simulations of the accretion disc. The models includes the thermo-viscous instability, irradiation from the central object and wind loss. I find that the outburst of GRS 1915+105 should last a minimum of 20 years and up to ˜ 100 years if the irradiation is playing a significant role in this system. The predicted recurrence times are of the order of 104 years, making the duty cycle of GRS 1915+105 to be a few 0.1%. I present a simple analytical method to describe the observable behaviour of long period black hole LMXBs, similar to GRS 1915+105. Constructing two simple models for the surface density in the disc, outburst and quiescence times are calculated as a function of orbital period. LMXBs are an important constituent of the X-ray light function (XLF) of giant elliptical galaxies. I find that the duty cycle can vary considerably with orbital period, with implications for modelling the XLF.

  4. HOT HIGH-MASS ACCRETION DISK CANDIDATES

    International Nuclear Information System (INIS)

    Beuther, H.; Walsh, A. J.; Longmore, S. N.

    2009-01-01

    To better understand the physical properties of accretion disks in high-mass star formation, we present a study of a dozen high-mass accretion disk candidates observed at high spatial resolution with the Australia Telescope Compact Array (ATCA) in the high-excitation (4,4) and (5,5) lines of NH 3 . All of our originally selected sources were detected in both NH 3 transitions, directly associated with CH 3 OH Class II maser emission and implying that high-excitation NH 3 lines are good tracers of the dense gas components in hot-core-type targets. Only the one source that did not satisfy the initial selection criteria remained undetected. From the 11 mapped sources, six show clear signatures of rotation and/or infall motions. These signatures vary from velocity gradients perpendicular to the outflows, to infall signatures in absorption against ultracompact H II regions, to more spherical infall signatures in emission. Although our spatial resolution is ∼1000 AU, we do not find clear Keplerian signatures in any of the sources. Furthermore, we also do not find flattened structures. In contrast to this, in several of the sources with rotational signatures, the spatial structure is approximately spherical with sizes exceeding 10 4 AU, showing considerable clumpy sub-structure at even smaller scales. This implies that on average typical Keplerian accretion disks-if they exist as expected-should be confined to regions usually smaller than 1000 AU. It is likely that these disks are fed by the larger-scale rotating envelope structure we observe here. Furthermore, we do detect 1.25 cm continuum emission in most fields of view. While in some cases weak cm continuum emission is associated with our targets, more typically larger-scale H II regions are seen offset more than 10'' from our sources. While these H II regions are unlikely to be directly related to the target regions, this spatial association nevertheless additionally stresses that high-mass star formation rarely

  5. MEASURING TINY MASS ACCRETION RATES ONTO YOUNG BROWN DWARFS

    International Nuclear Information System (INIS)

    Herczeg, Gregory J.; Cruz, Kelle L.; Hillenbrand, Lynne A.

    2009-01-01

    We present low-resolution Keck I/LRIS spectra spanning from 3200 to 9000 A of nine young brown dwarfs and three low-mass stars in the TW Hya Association and in Upper Sco. The optical spectral types of the brown dwarfs range from M5.5 to M8.75, though two have near-IR spectral types of early L dwarfs. We report new accretion rates derived from excess Balmer continuum emission for the low-mass stars TW Hya and Hen 3-600A and the brown dwarfs 2MASS J12073347-3932540, UScoCTIO 128, SSSPM J1102-3431, USco J160606.29-233513.3, DENIS-P J160603.9-205644, and Oph J162225-240515B, and upper limits on accretion for the low-mass star Hen 3-600B and the brown dwarfs UScoCTIO 112, Oph J162225-240515A, and USco J160723.82-221102.0. For the six brown dwarfs in our sample that are faintest at short wavelengths, the accretion luminosity or upper limit is measurable only when the image is binned over large wavelength intervals. This method extends our sensitivity to accretion rate down to ∼10 -13 M sun yr -1 for brown dwarfs. Since the ability to measure an accretion rate from excess Balmer continuum emission depends on the contrast between excess continuum emission and the underlying photosphere, for objects with earlier spectral types the upper limit on accretion rate is much higher. Absolute uncertainties in our accretion rate measurements of ∼3-5 include uncertainty in accretion models, brown dwarf masses, and distance. The accretion rate of 2 x 10 -12 M sun yr -1 onto 2MASS J12073347-3932540 is within 15% of two previous measurements, despite large changes in the Hα flux.

  6. Formation of primordial supermassive stars by rapid mass accretion

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    Hosokawa, Takashi; Yoshida, Naoki [Department of Physics and Research Center for the Early Universe, The University of Tokyo, Tokyo 113-0033 (Japan); Yorke, Harold W. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Inayoshi, Kohei; Omukai, Kazuyuki, E-mail: takashi.hosokawa@phys.s.u-tokyo.ac.jp, E-mail: hosokwtk@gmail.com [Department of Physics, Kyoto University, Kyoto 606-8502 (Japan)

    2013-12-01

    Supermassive stars (SMSs) forming via very rapid mass accretion ( M-dot {sub ∗}≳0.1 M{sub ⊙} yr{sup −1}) could be precursors of supermassive black holes observed beyond a redshift of about six. Extending our previous work, here we study the evolution of primordial stars growing under such rapid mass accretion until the stellar mass reaches 10{sup 4–5} M {sub ☉}. Our stellar evolution calculations show that a star becomes supermassive while passing through the 'supergiant protostar' stage, whereby the star has a very bloated envelope and a contracting inner core. The stellar radius increases monotonically with the stellar mass until ≅ 100 AU for M {sub *} ≳ 10{sup 4} M {sub ☉}, after which the star begins to slowly contract. Because of the large radius, the effective temperature is always less than 10{sup 4} K during rapid accretion. The accreting material is thus almost completely transparent to the stellar radiation. Only for M {sub *} ≳ 10{sup 5} M {sub ☉} can stellar UV feedback operate and disturb the mass accretion flow. We also examine the pulsation stability of accreting SMSs, showing that the pulsation-driven mass loss does not prevent stellar mass growth. Observational signatures of bloated SMSs should be detectable with future observational facilities such as the James Webb Space Telescope. Our results predict that an inner core of the accreting SMS should suffer from the general relativistic instability soon after the stellar mass exceeds 10{sup 5} M {sub ☉}. An extremely massive black hole should form after the collapse of the inner core.

  7. Role of protein and amino acids in promoting lean mass accretion with resistance exercise and attenuating lean mass loss during energy deficit in humans.

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    Churchward-Venne, Tyler A; Murphy, Caoileann H; Longland, Thomas M; Phillips, Stuart M

    2013-08-01

    Amino acids are major nutrient regulators of muscle protein turnover. After protein ingestion, hyperaminoacidemia stimulates increased rates of skeletal muscle protein synthesis, suppresses muscle protein breakdown, and promotes net muscle protein accretion for several hours. These acute observations form the basis for strategized protein intake to promote lean mass accretion, or prevent lean mass loss over the long term. However, factors such as protein dose, protein source, and timing of intake are important in mediating the anabolic effects of amino acids on skeletal muscle and must be considered within the context of evaluating the reported efficacy of long-term studies investigating protein supplementation as part of a dietary strategy to promote lean mass accretion and/or prevent lean mass loss. Current research suggests that dietary protein supplementation can augment resistance exercise-mediated gains in skeletal muscle mass and strength and can preserve skeletal muscle mass during periods of diet-induced energy restriction. Perhaps less appreciated, protein supplementation can augment resistance training-mediated gains in skeletal muscle mass even in individuals habitually consuming 'adequate' (i.e., >0.8 g kg⁻¹ day⁻¹) protein. Additionally, overfeeding energy with moderate to high-protein intake (15-25 % protein or 1.8-3.0 g kg⁻¹ day⁻¹) is associated with lean, but not fat mass accretion, when compared to overfeeding energy with low protein intake (5 % protein or ~0.68 g kg⁻¹ day⁻¹). Amino acids represent primary nutrient regulators of skeletal muscle anabolism, capable of enhancing lean mass accretion with resistance exercise and attenuating the loss of lean mass during periods of energy deficit, although factors such as protein dose, protein source, and timing of intake are likely important in mediating these effects.

  8. Mass-Accretion effects on white dwarf interiors

    International Nuclear Information System (INIS)

    Canal, R.; Hernanz, M.; Isern, J.; Labay, J.; Mochkovitch, R.

    1986-01-01

    There is observational evidence of the presence of young neutron stars in old binary systems. A likely explanation is that those neutron stars were produced in the collapse of old C+O white dwarfs. Old white dwarfs being cold and at least partially solid, accretion-induced mass growth should finally lead in a number of cases, to their collapse rather than to their explosion. We show in detail how mass accretion on initially solid white dwarfs can leave central solid cores when dynamical instability sets in. We also study the different effects of the existence of such cores on the outcome of the competition between thermonuclear explosion and gravitational collapse

  9. On the Maximum Mass of Accreting Primordial Supermassive Stars

    Energy Technology Data Exchange (ETDEWEB)

    Woods, T. E.; Heger, Alexander [Monash Centre for Astrophysics, School of Physics and Astronomy, Monash University, VIC 3800 (Australia); Whalen, Daniel J. [Institute of Cosmology and Gravitation, University of Portsmouth, Dennis Sciama Building, Portsmouth PO1 3FX (United Kingdom); Haemmerlé, Lionel; Klessen, Ralf S. [Universität Heidelberg, Zentrum für Astronomie, Institut für Theoretische. Astrophysik, Albert-Ueberle-Str. 2, D-69120 Heidelberg (Germany)

    2017-06-10

    Supermassive primordial stars are suspected to be the progenitors of the most massive quasars at z ∼ 6. Previous studies of such stars were either unable to resolve hydrodynamical timescales or considered stars in isolation, not in the extreme accretion flows in which they actually form. Therefore, they could not self-consistently predict their final masses at collapse, or those of the resulting supermassive black hole seeds, but rather invoked comparison to simple polytropic models. Here, we systematically examine the birth, evolution, and collapse of accreting, non-rotating supermassive stars under accretion rates of 0.01–10 M {sub ⊙} yr{sup −1} using the stellar evolution code Kepler . Our approach includes post-Newtonian corrections to the stellar structure and an adaptive nuclear network and can transition to following the hydrodynamic evolution of supermassive stars after they encounter the general relativistic instability. We find that this instability triggers the collapse of the star at masses of 150,000–330,000 M {sub ⊙} for accretion rates of 0.1–10 M {sub ⊙} yr{sup −1}, and that the final mass of the star scales roughly logarithmically with the rate. The structure of the star, and thus its stability against collapse, is sensitive to the treatment of convection and the heat content of the outer accreted envelope. Comparison with other codes suggests differences here may lead to small deviations in the evolutionary state of the star as a function of time, that worsen with accretion rate. Since the general relativistic instability leads to the immediate death of these stars, our models place an upper limit on the masses of the first quasars at birth.

  10. Mass-accreting white dwarfs and type Ia supernovae

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    Wang, Bo

    2018-05-01

    Type Ia supernovae (SNe Ia) play a prominent role in understanding the evolution of the Universe. They are thought to be thermonuclear explosions of mass-accreting carbon-oxygen white dwarfs (CO WDs) in binaries, although the mass donors of the accreting WDs are still not well determined. In this article, I review recent studies on mass-accreting WDs, including H- and He-accreting WDs. I also review currently most studied progenitor models of SNe Ia, i.e., the single-degenerate model (including the WD+MS channel, the WD+RG channel and the WD+He star channel), the double-degenerate model (including the violent merger scenario) and the sub-Chandrasekhar mass model. Recent progress on these progenitor models is discussed, including the initial parameter space for producing SNe Ia, the binary evolutionary paths to SNe Ia, the progenitor candidates for SNe Ia, the possible surviving companion stars of SNe Ia, some observational constraints, etc. Some other potential progenitor models of SNe Ia are also summarized, including the hybrid CONe WD model, the core-degenerate model, the double WD collision model, the spin-up/spin-down model and the model of WDs near black holes. To date, it seems that two or more progenitor models are needed to explain the observed diversity among SNe Ia.

  11. Accreting Millisecond Pulsars: Neutron Star Masses and Radii

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    Strohmayer, Tod

    2004-01-01

    High amplitude X-ray brightness oscillations during thermonuclear X-ray bursts were discovered with the Rossi X-ray Timing Explorer (RXTE) in early 1996. Spectral and timing evidence strongly supports the conclusion that these oscillations are caused by rotational modulation of the burst emission and that they reveal the spin frequency of neutron stars in low mass X-ray binaries. The recent discovery of X-ray burst oscillations from two accreting millisecond pulsars has confirmed this basic picture and provided a new route to measuring neutron star properties and constraining the dense matter equation of state. I will briefly summarize the current observational understanding of accreting millisecond pulsars, and describe recent attempts to determine the mass and radius of the neutron star in XTE J1814-338.

  12. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep.

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    Rozance, Paul J; Zastoupil, Laura; Wesolowski, Stephanie R; Goldstrohm, David A; Strahan, Brittany; Cree-Green, Melanie; Sheffield-Moore, Melinda; Meschia, Giacomo; Hay, William W; Wilkening, Randall B; Brown, Laura D

    2018-01-01

    Adults who were affected by intrauterine growth restriction (IUGR) suffer from reductions in muscle mass, which may contribute to insulin resistance and the development of diabetes. We demonstrate slower hindlimb linear growth and muscle protein synthesis rates that match the reduced hindlimb blood flow and oxygen consumption rates in IUGR fetal sheep. These adaptations resulted in hindlimb blood flow rates in IUGR that were similar to control fetuses on a weight-specific basis. Net hindlimb glucose uptake and lactate output rates were similar between groups, whereas amino acid uptake was significantly lower in IUGR fetal sheep. Among all fetuses, blood O 2 saturation and plasma glucose, insulin and insulin-like growth factor-1 were positively associated and norepinephrine was negatively associated with hindlimb weight. These results further our understanding of the metabolic and hormonal adaptations to reduced oxygen and nutrient supply with placental insufficiency that develop to slow hindlimb growth and muscle protein accretion. Reduced skeletal muscle mass in the fetus with intrauterine growth restriction (IUGR) persists into adulthood and may contribute to increased metabolic disease risk. To determine how placental insufficiency with reduced oxygen and nutrient supply to the fetus affects hindlimb blood flow, substrate uptake and protein accretion rates in skeletal muscle, late gestation control (CON) (n = 8) and IUGR (n = 13) fetal sheep were catheterized with aortic and femoral catheters and a flow transducer around the external iliac artery. Muscle protein kinetic rates were measured using isotopic tracers. Hindlimb weight, linear growth rate, muscle protein accretion rate and fractional synthetic rate were lower in IUGR compared to CON (P fetal norepinephrine and reduced IGF-1 and insulin. © 2017 The Authors. The Journal of Physiology © 2017 The Physiological Society.

  13. Accretion and jets from stellar-mass to supermassive black holes

    NARCIS (Netherlands)

    Connors, R.M.T.

    2017-01-01

    Accretion and jets occur in many astrophysical systems across a multitude of size and mass scales, and environments. As such, the study of accretion and jet physics has for decades been, and still remains, a hot topic in astrophysics. Accretion onto black holes has particular significance for many

  14. Nutritional interventions to preserve skeletal muscle mass

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    Backx, Evelien M.P.

    2016-01-01

    Muscle mass is the main predictor for muscle strength and physical function. The amount of muscle mass can decline rapidly during periods of reduced physical activity or during periods of energy intake restriction. For athletes, it is important to maintain muscle mass, since the loss of muscle is

  15. Smearing of mass accretion rate variation by viscous processes in accretion disks in compact binary systems

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    Ghosh, A.; Chakrabarti, Sandip K.

    2016-09-01

    Variation of mass supply rate from the companion can be smeared out by viscous processes inside an accretion disk. Hence, by the time the flow reaches the inner edge, the variation in X-rays need not reflect the true variation of the mass supply rate at the outer edge. However, if the viscosity fluctuates around a mean value, one would expect the viscous time scale t_{{visc}} also to spread around a mean value. In high mass X-ray binaries, which are thought to be primarily wind-fed, the size of the viscous Keplerian disk is smaller and thus such a spread could be lower as compared to the low mass X-ray binaries which are primarily fed by Roche lobe overflow. If there is an increasing or decreasing trend in viscosity, the interval between enhanced emission would be modified systematically. In the absence of a detailed knowledge about the variation of mass supply rates at the outer edge, we study ideal circumstances where modulation must take place exactly in orbital time scales, such as when there is an ellipticity in the orbit. We study a few compact binaries using long term All Sky monitor (ASM) data (1.5-12 keV) of Rossi X-ray Timing Explorer (RXTE) and all sky survey data (15-50 keV) of Swift satellites by different methods to look for such smearing effects and to infer what these results can tell us about the viscous processes inside the respective disks. We employ three different methods to seek imprints of periodicity on the X-ray variation and found that in all the cases, the location of the peak in the power density spectra is consistent with the orbital frequencies. Interestingly, in high mass X-ray binaries the peaks are sharp with high rms values, consistent with a small Keplerian disk in a wind fed system. However, in low mass X-ray binaries with larger Keplerian disk component, the peaks are spreaded out with much lower rms values. X-ray reflections, or superhump phenomena which may also cause such X-ray modulations would not be affected by the size of

  16. The time course of myonuclear accretion during hypertrophy in young adult and older rat plantaris muscle

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    van der Meer, S.F.T.; Jaspers, R.T.; Jones, D.A.; Degens, H.

    2011-01-01

    To investigate whether accretion of myonuclei precedes or follows the increase in fibre cross-sectional area and whether this time course is affected by age, left plantaris muscle of 5- and 25-month-old male Wistar rats was overloaded by denervation of its synergists for 1, 2 or 4 weeks.

  17. Study of high energy emissions from stellar mass accreting holes

    International Nuclear Information System (INIS)

    Cadolle-Bel, Marion

    2006-01-01

    The present work is dedicated to the study of various X-ray binary Systems harbouring accreting stellar mass black holes (or candidates) associated in X-ray binary Systems mainly through the spectral and timing properties of the high energy 3 keV"-"1 MeV emission, sometimes completed by observations performed in radio, near-infrared and optical. The first part is devoted to accretion physics phenomena and the challenges of understanding the X-ray/gamma emission produced with the modeling of such high energy processes. Then I will define in a second part the instruments on board INTEGRAL and the way coded masked aperture is employed. In a third part, I will develop the standard data reduction analysis and my own contribution in improving the usual software before detailing the specific informatics tools I have developed for my own analysis. In the fourth part I will turn towards the deep analysis and interpretations I have performed on several black hole X-ray binary Systems chosen properly: the persistent black hole source Cygnus X-1 which has been studied since several years and surprised us by a high-energy excess detected; two new transient sources which provide interesting information, XTE J1720-318 located in the galactic bulge and SWIFT J1753.5-0127, probably situated in the halo. I will also detail my work on H 1743-322, recently identified by INTEGRAL as the HEAO source discovered in 1977, and on three (almost) persistent micro-quasars with superluminal jets, 1E 1740.7-2942, GRS 1758-258 and GRS 1915+105. I will analyze for each source spectral parameter evolutions and their links with each other during state transitions. I will then discuss the presence of two different X/gamma-ray emitting media with a relatively changing geometry. While establishing a cyclic order for the different variability classes of GRS 1915+105 observed during ten years, I will propose an interpretation for such behaviour, compatible with the theoretical predictions of the

  18. The Quasar Accretion Disk Size-Black Hole Mass Relation

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    Morgan, Christopher W.; Kochanek, C. S.; Morgan, Nicholas D.; Falco, Emilio E.

    2010-04-01

    We use the microlensing variability observed for 11 gravitationally lensed quasars to show that the accretion disk size at a rest-frame wavelength of 2500 Å is related to the black hole mass by log(R 2500/cm) = (15.78 ± 0.12) + (0.80 ± 0.17)log(M BH/109 M sun). This scaling is consistent with the expectation from thin-disk theory (R vprop M 2/3 BH), but when interpreted in terms of the standard thin-disk model (T vprop R -3/4), it implies that black holes radiate with very low efficiency, log(η) = -1.77 ± 0.29 + log(L/L E), where η =L/(\\dot{M}c^2). Only by making the maximum reasonable shifts in the average inclination, Eddington factors, and black hole masses can we raise the efficiency estimate to be marginally consistent with typical efficiency estimates (η ≈ 10%). With one exception, these sizes are larger by a factor of ~4 than the size needed to produce the observed 0.8 μm quasar flux by thermal radiation from a thin disk with the same T vprop R -3/4 temperature profile. While scattering a significant fraction of the disk emission on large scales or including a large fraction of contaminating line emission can reduce the size discrepancy, resolving it also appears to require that accretion disks have flatter temperature/surface brightness profiles. Based on observations obtained with the Small and Moderate Aperture Research Telescope System (SMARTS) 1.3 m, which is operated by the SMARTS Consortium, the Apache Point Observatory 3.5 m telescope, which is owned and operated by the Astrophysical Research Consortium, the WIYN Observatory which is owned and operated by the University of Wisconsin, Indiana University, Yale University, and the National Optical Astronomy Observatories (NOAO), the 6.5 m Magellan Baade telescope, which is a collaboration between the observatories of the Carnegie Institution of Washington (OCIW), University of Arizona, Harvard University, University of Michigan, and Massachusetts Institute of Technology, and observations made

  19. Probing the Jet Turnover Frequency Dependence on Mass and Mass Accretion Rate

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    Hammerstein, Erica; Gültekin, Kayhan; King, Ashley

    2018-01-01

    We have examined a sample of 15 sub-Eddington supermassive black holes (SMBHs) in a variety of galaxy classifications to further understand the proposed fundamental plane of black hole activity and scaling relations between black hole masses and their radio and X-ray luminosities. This plane describes black holes from stellar-mass to supermassive. The physics probed by these sub-Eddington systems is thought to be a radiatively inefficient, jet-dominated accretion flow. By studying black holes in this regime, we can learn important information on the disk-jet connection for accreting black holes.A key factor in studying the fundamental plane is the turnover frequency — the frequency at which emission transitions from optically thick at lower frequencies to optically thin at higher frequencies. This turnover point can be measured by observing the source in both radio and X-ray. Our project aims to test the dependence of the turnover frequency on mass and mass accretion rate.Radio observations of the sample were obtained using the Karl G. Jansky Very Large Array (VLA) in the range of 5-40 GHz across four different frequency bands in A configuration to give the highest spatial resolution to focus on the core emission. Our carefully chosen sample of SMBHs with dynamically measured masses consists of two sub-samples: those with approximately constant mass accretion rate (LX/LEdd ~ 10‑7) and those with approximately constant mass (MBH ~ 108 Msun). X-ray data were obtained from archival Chandra observations. To find the turnover frequency, we used Markov Chain Monte Carlo methods to fit two power laws to the radio data and the archival X-ray data. The intersection of the radio and X-ray fits is the turnover frequency.We present the results for both subsamples of SMBHs and their relationship between the turnover frequency and X-ray luminosity, which we take to scale with mass accretion rate, and jet power derived from both radio and X-ray properties.

  20. Steamworlds: Atmospheric Structure and Critical Mass of Planets Accreting Icy Pebbles

    International Nuclear Information System (INIS)

    Chambers, John

    2017-01-01

    In the core accretion model, gas-giant planets first form a solid core, which then accretes gas from a protoplanetary disk when the core exceeds a critical mass. Here, we model the atmosphere of a core that grows by accreting ice-rich pebbles. The ice fraction of pebbles evaporates in warm regions of the atmosphere, saturating it with water vapor. Excess water precipitates to lower altitudes. Beneath an outer radiative region, the atmosphere is convective, following a moist adiabat in saturated regions due to water condensation and precipitation. Atmospheric mass, density, and temperature increase with core mass. For nominal model parameters, planets with core masses (ice + rock) between 0.08 and 0.16 Earth masses have surface temperatures between 273 and 647 K and form an ocean. In more massive planets, water exists as a supercritical convecting fluid mixed with gas from the disk. Typically, the core mass reaches a maximum (the critical mass) as a function of the total mass when the core is 2–5 Earth masses. The critical mass depends in a complicated way on pebble size, mass flux, and dust opacity due to the occasional appearance of multiple core-mass maxima. The core mass for an atmosphere of 50% hydrogen and helium may be a more robust indicator of the onset of gas accretion. This mass is typically 1–3 Earth masses for pebbles that are 50% ice by mass, increasing with opacity and pebble flux and decreasing with pebble ice/rock ratio.

  1. Steamworlds: Atmospheric Structure and Critical Mass of Planets Accreting Icy Pebbles

    Energy Technology Data Exchange (ETDEWEB)

    Chambers, John, E-mail: jchambers@carnegiescience.edu [Carnegie Institution for Science Department of Terrestrial Magnetism, 5241 Broad Branch Road, NW, Washington, DC 20015 (United States)

    2017-11-01

    In the core accretion model, gas-giant planets first form a solid core, which then accretes gas from a protoplanetary disk when the core exceeds a critical mass. Here, we model the atmosphere of a core that grows by accreting ice-rich pebbles. The ice fraction of pebbles evaporates in warm regions of the atmosphere, saturating it with water vapor. Excess water precipitates to lower altitudes. Beneath an outer radiative region, the atmosphere is convective, following a moist adiabat in saturated regions due to water condensation and precipitation. Atmospheric mass, density, and temperature increase with core mass. For nominal model parameters, planets with core masses (ice + rock) between 0.08 and 0.16 Earth masses have surface temperatures between 273 and 647 K and form an ocean. In more massive planets, water exists as a supercritical convecting fluid mixed with gas from the disk. Typically, the core mass reaches a maximum (the critical mass) as a function of the total mass when the core is 2–5 Earth masses. The critical mass depends in a complicated way on pebble size, mass flux, and dust opacity due to the occasional appearance of multiple core-mass maxima. The core mass for an atmosphere of 50% hydrogen and helium may be a more robust indicator of the onset of gas accretion. This mass is typically 1–3 Earth masses for pebbles that are 50% ice by mass, increasing with opacity and pebble flux and decreasing with pebble ice/rock ratio.

  2. Final stages of evolution of cold, mass-accreting white dwarfs

    International Nuclear Information System (INIS)

    Hernanz, M.; Isern, J.; Canal, R.; Labay, J.; Mochkovitch, R.

    1988-01-01

    The evolution of solid C + O white dwarf models upon mass accretion is calculated up to the point of either explosive thermonuclear ignition or gravitational collapse. It is shown that both explosions and quiet collapses to a neutron star are possible for each of two different phase diagrams for high-density C + O mixtures. The ranges of initial masses and temperatures and of accretion rates leading to the different outcomes are determined. Problems concerning the chemical composition of the accreted matter and the effects of tidal dissipation are discussed. 68 references

  3. EFFECTS OF BIASES IN VIRIAL MASS ESTIMATION ON COSMIC SYNCHRONIZATION OF QUASAR ACCRETION

    International Nuclear Information System (INIS)

    Steinhardt, Charles L.

    2011-01-01

    Recent work using virial mass estimates and the quasar mass-luminosity plane has yielded several new puzzles regarding quasar accretion, including a sub-Eddington boundary (SEB) on most quasar accretion, near-independence of the accretion rate from properties of the host galaxy, and a cosmic synchronization of accretion among black holes of a common mass. We consider how these puzzles might change if virial mass estimation turns out to have a systematic bias. As examples, we consider two recent claims of mass-dependent biases in Mg II masses. Under any such correction, the surprising cosmic synchronization of quasar accretion rates and independence from the host galaxy remain. The slope and location of the SEB are very sensitive to biases in virial mass estimation, and various mass calibrations appear to favor different possible physical explanations for feedback between the central black hole and its environment. The alternative mass estimators considered do not simply remove puzzling quasar behavior, but rather replace it with new puzzles that may be more difficult to solve than those using current virial mass estimators and the Shen et al. catalog.

  4. Mass accretion rate fluctuations in black hole X-ray binaries

    NARCIS (Netherlands)

    Rapisarda, S.

    2017-01-01

    This thesis is about the first systematic and quantitative application of propagating mass accretion rate fluctuations models to black hole X-ray binaries. Black hole X-ray binaries are systems consisting of a solar mass star orbiting around a stellar mass black hole. Eventually, the black hole

  5. X-RAY DETERMINATION OF THE VARIABLE RATE OF MASS ACCRETION ONTO TW HYDRAE

    Energy Technology Data Exchange (ETDEWEB)

    Brickhouse, N. S.; Cranmer, S. R.; Dupree, A. K.; Guenther, H. M.; Wolk, S. J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Luna, G. J. M. [Current address: Instituto de Astronomia y Fisica del Espacio (IAFE), Buenos Aires (Argentina)

    2012-12-01

    Diagnostics of electron temperature (T{sub e} ), electron density (n{sub e} ), and hydrogen column density (N{sub H}) from the Chandra High Energy Transmission Grating spectrum of He-like Ne IX in TW Hydrae (TW Hya), in conjunction with a classical accretion model, allow us to infer the accretion rate onto the star directly from measurements of the accreting material. The new method introduces the use of the absorption of Ne IX lines as a measure of the column density of the intervening, accreting material. On average, the derived mass accretion rate for TW Hya is 1.5 Multiplication-Sign 10{sup -9} M{sub Sun} yr{sup -1}, for a stellar magnetic field strength of 600 G and a filling factor of 3.5%. Three individual Chandra exposures show statistically significant differences in the Ne IX line ratios, indicating changes in N{sub H}, T{sub e} , and n{sub e} by factors of 0.28, 1.6, and 1.3, respectively. In exposures separated by 2.7 days, the observations reported here suggest a five-fold reduction in the accretion rate. This powerful new technique promises to substantially improve our understanding of the accretion process in young stars.

  6. Low Muscle Mass and Breast Cancer Survival

    Science.gov (United States)

    In a new study, researchers compared the risk of death for women with breast cancer who had low skeletal muscle mass, or sarcopenia, at diagnosis and women who had adequate muscle mass. Learn what they found and what it might mean for patients in this Cancer Currents blog post.

  7. Accretion of satellites on to central galaxies in clusters: merger mass ratios and orbital parameters

    Science.gov (United States)

    Nipoti, Carlo; Giocoli, Carlo; Despali, Giulia

    2018-05-01

    We study the statistical properties of mergers between central and satellite galaxies in galaxy clusters in the redshift range 0 identify dark-matter haloes, we construct halo merger trees for different values of the overdensity Δc. While the virial overdensity definition allows us to probe the accretion of satellites at the cluster virial radius rvir, higher overdensities probe satellite mergers in the central region of the cluster, down to ≈0.06rvir, which can be considered a proxy for the accretion of satellite galaxies on to central galaxies. We find that the characteristic merger mass ratio increases for increasing values of Δc: more than 60 per cent of the mass accreted by central galaxies since z ≈ 1 comes from major mergers. The orbits of satellites accreting on to central galaxies tend to be more tangential and more bound than orbits of haloes accreting at the virial radius. The obtained distributions of merger mass ratios and orbital parameters are useful to model the evolution of the high-mass end of the galaxy scaling relations without resorting to hydrodynamic cosmological simulations.

  8. Mechanosensitive molecular networks involved in transducing resistance exercise-signals into muscle protein accretion

    Directory of Open Access Journals (Sweden)

    Emil Rindom

    2016-11-01

    Full Text Available Loss of skeletal muscle myofibrillar protein with disease and/or inactivity can severely deteriorate muscle strength and function. Strategies to counteract wasting of muscle myofibrillar protein are therefore desirable and invite for considerations on the potential superiority of specific modes of resistance exercise and/or the adequacy of low load resistance exercise regimens as well as underlying mechanisms. In this regard, delineation of the potentially mechanosensitive molecular mechanisms underlying muscle protein synthesis (MPS, may contribute to understanding on how differentiated resistance exercise can transduce a mechanical signal into stimulation of muscle accretion. Recent findings suggest specific upstream exercise-induced mechano-sensitive myocellular signaling pathways to converge on mammalian target of rapamycin complex 1 (mTORC1, to influence MPS. This may e.g. implicate mechanical activation of signaling through a diacylglycerol kinase (DGKζ-phosphatidic acid (PA axis or implicate integrin deformation to signal through a Focal adhesion kinase (FAK-Tuberous Sclerosis Complex 2TSC2-Ras homolog enriched in brain (Rheb axis. Moreover, since initiation of translation is reliant on mRNA, it is also relevant to consider potentially mechanosensitive signaling pathways involved in muscle myofibrillar gene transcription and whether some of these pathways converge with those affecting mTORC1 activation for MPS. In this regard, recent findings suggest how mechanical stress may implicate integrin deformation and/or actin dynamics to signal through a Ras homolog gene family member A protein (RhoA-striated muscle activator of Rho signaling (STARS axis or how it may implicate deformation of Notch to affect Bone Morphogenetic Protein (BMP signaling through a small mother of decapentaplegic (Smad axis.

  9. PBH mass growth through radial accretion during the radiation dominated era

    Energy Technology Data Exchange (ETDEWEB)

    Lora-Clavijo, F.D. [Instituto de Astronomía, Universidad Nacional Autónoma de México, AP 70-264, Distrito Federal 04510 (Mexico); Guzmán, F.S.; Cruz-Osorio, A., E-mail: fdlora@astro.unam.mx, E-mail: guzman@ifm.umich.mx, E-mail: alejandro@ifm.umich.mx [Instituto de Física y Matemáticas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio C-3, Cd. Universitaria, 58040 Morelia, Michoacán (Mexico)

    2013-12-01

    We model the radial accretion of radiation on Primordial Black Holes (PBH) by numerically solving Einstein's equations coupled to an ultrarelativistic ideal gas with equation of state p = ρ/3. We calculate the final mass of a black hole by the integration of the accreted radiation energy density during the leptonic era between t ∼ 10{sup −4}s to t ∼ 10{sup 2}s after the Big Bang. Our results indicate that small PBHs with initial masses between 10{sup −4} to 1M{sub ⊙} may grow up to hundreds of solar masses, and thus can be SMBH seeds. On the other hand, PBHs formed at t ∼ 1s with initial mass between 900 and ∼ 980M{sub ⊙}, by the time t ∼ 100s show masses of 10{sup 4} to 10{sup 6}M{sub ⊙} which are masses of seeds or already formed SMBHs. The fact that we consider only radial flow implies that our results work well as limiting cases, and it is expected that under more general scenarios the accretion rates may change significantly. Nevertheless we show that it is possible that SMBHs can be PBHs that grew due to the accretion of radiation.

  10. Is Episodic Accretion Necessary to Resolve the Luminosity Problem in Low-Mass Protostars?

    Science.gov (United States)

    Sevrinsky, Raymond Andrew; Dunham, Michael

    2017-01-01

    In this contribution, we compare the results of protostellar accretion simulations for scenarios both containing and lacking episodic accretion activity. We determine synthetic observational signatures for collapsing protostars by taking hydrodynamical simulations predicting highly variable episodic accretion events, filtering out the stochastic behavior by applying power law fits to the mass accretion rates onto the disk and central star, and using the filtered rates as inputs to two-dimensional radiative transfer calculations. The spectral energy distributions generated by these calculations are used to calculate standard observational signatures of Lbol and Tbol, and compared directly to a sample of 230 embedded protostars. We explore the degree to which these continually declining accretion models successfully reproduce the observed spread of protostellar luminosities, and examine their consistency with the prior variable models to investigate the degree to which episodic accretion bursts are necessary in protostellar formation theories to match observations of field protostars. The SAO REU program is funded in part by the National Science Foundation REU and Department of Defense ASSURE programs under NSF Grant no. 1262851, and by the Smithsonian Institution.

  11. Imprint of accretion disk-induced migration on gravitational waves from extreme mass ratio inspirals.

    Science.gov (United States)

    Yunes, Nicolás; Kocsis, Bence; Loeb, Abraham; Haiman, Zoltán

    2011-10-21

    We study the effects of a thin gaseous accretion disk on the inspiral of a stellar-mass black hole into a supermassive black hole. We construct a phenomenological angular momentum transport equation that reproduces known disk effects. Disk torques modify the gravitational wave phase evolution to detectable levels with LISA for reasonable disk parameters. The Fourier transform of disk-modified waveforms acquires a correction with a different frequency trend than post-Newtonian vacuum terms. Such inspirals could be used to detect accretion disks with LISA and to probe their physical parameters. © 2011 American Physical Society

  12. Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous mice.

    Directory of Open Access Journals (Sweden)

    Susan M Lang

    Full Text Available The present study addressed the hypothesis that reducing mTOR, as seen in mTOR heterozygous (+/- mice, would exaggerate the changes in protein synthesis and degradation observed during hindlimb immobilization as well as impair normal muscle regrowth during the recovery period. Atrophy was produced by unilateral hindlimb immobilization and data compared to the contralateral gastrocnemius. In wild-type (WT mice, the gradual loss of muscle mass plateaued by day 7. This response was associated with a reduction in basal protein synthesis and development of leucine resistance. Proteasome activity was consistently elevated, but atrogin-1 and MuRF1 mRNAs were only transiently increased returning to basal values by day 7. When assessed 7 days after immobilization, the decreased muscle mass and protein synthesis and increased proteasome activity did not differ between WT and mTOR(+/- mice. Moreover, the muscle inflammatory cytokine response did not differ between groups. After 10 days of recovery, WT mice showed no decrement in muscle mass, and this accretion resulted from a sustained increase in protein synthesis and a normalization of proteasome activity. In contrast, mTOR(+/- mice failed to fully replete muscle mass at this time, a defect caused by the lack of a compensatory increase in protein synthesis. The delayed muscle regrowth of the previously immobilized muscle in the mTOR(+/- mice was associated with a decreased raptor•4EBP1 and increased raptor•Deptor binding. Slowed regrowth was also associated with a sustained inflammatory response (e.g., increased TNFα and CD45 mRNA during the recovery period and a failure of IGF-I to increase as in WT mice. These data suggest mTOR is relatively more important in regulating the accretion of muscle mass during recovery than the loss of muscle during the atrophy phase, and that protein synthesis is more sensitive than degradation to the reduction in mTOR during muscle regrowth.

  13. Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous mice.

    Science.gov (United States)

    Lang, Susan M; Kazi, Abid A; Hong-Brown, Ly; Lang, Charles H

    2012-01-01

    The present study addressed the hypothesis that reducing mTOR, as seen in mTOR heterozygous (+/-) mice, would exaggerate the changes in protein synthesis and degradation observed during hindlimb immobilization as well as impair normal muscle regrowth during the recovery period. Atrophy was produced by unilateral hindlimb immobilization and data compared to the contralateral gastrocnemius. In wild-type (WT) mice, the gradual loss of muscle mass plateaued by day 7. This response was associated with a reduction in basal protein synthesis and development of leucine resistance. Proteasome activity was consistently elevated, but atrogin-1 and MuRF1 mRNAs were only transiently increased returning to basal values by day 7. When assessed 7 days after immobilization, the decreased muscle mass and protein synthesis and increased proteasome activity did not differ between WT and mTOR(+/-) mice. Moreover, the muscle inflammatory cytokine response did not differ between groups. After 10 days of recovery, WT mice showed no decrement in muscle mass, and this accretion resulted from a sustained increase in protein synthesis and a normalization of proteasome activity. In contrast, mTOR(+/-) mice failed to fully replete muscle mass at this time, a defect caused by the lack of a compensatory increase in protein synthesis. The delayed muscle regrowth of the previously immobilized muscle in the mTOR(+/-) mice was associated with a decreased raptor•4EBP1 and increased raptor•Deptor binding. Slowed regrowth was also associated with a sustained inflammatory response (e.g., increased TNFα and CD45 mRNA) during the recovery period and a failure of IGF-I to increase as in WT mice. These data suggest mTOR is relatively more important in regulating the accretion of muscle mass during recovery than the loss of muscle during the atrophy phase, and that protein synthesis is more sensitive than degradation to the reduction in mTOR during muscle regrowth.

  14. Accretion of Fat-Free Mass Rather Than Fat Mass in Infancy Is Positively Associated with Linear Growth in Childhood.

    Science.gov (United States)

    Admassu, Bitiya; Ritz, Christian; Wells, Jonathan C K; Girma, Tsinuel; Andersen, Gregers S; Belachew, Tefera; Owino, Victor; Michaelsen, Kim F; Abera, Mubarek; Wibaek, Rasmus; Friis, Henrik; Kæstel, Pernille

    2018-04-01

    We have previously shown that fat-free mass (FFM) at birth is associated with height at 2 y of age in Ethiopian children. However, to our knowledge, the relation between changes in body composition during early infancy and later linear growth has not been studied. This study examined the associations of early infancy fat mass (FM) and FFM accretion with linear growth from 1 to 5 y of age in Ethiopian children. In the infant Anthropometry and Body Composition (iABC) study, a prospective cohort study was carried out in children in Jimma, Ethiopia, followed from birth to 5 y of age. FM and FFM were measured ≤6 times from birth to 6 mo by using air-displacement plethysmography. Linear mixed-effects models were used to identify associations between standardized FM and FFM accretion rates during early infancy and linear growth from 1 to 5 y of age. Standardized accretion rates were obtained by dividing FM and FFM accretion by their respective SD. FFM accretion from 0 to 6 mo of age was positively associated with length at 1 y (β = 0.64; 95% CI: 0.19, 1.09; P = 0.005) and linear growth from 1 to 5 y (β = 0.63; 95% CI: 0.19, 1.07; P = 0.005). The strongest association with FFM accretion was observed at 1 y. The association with linear growth from 1 to 5 y was mainly engendered by the 1-y association. FM accretion from 0 to 4 mo was positively associated with linear growth from 1 to 5 y (β = 0.45; 95% CI: 0.02, 0.88; P = 0.038) in the fully adjusted model. In Ethiopian children, FFM accretion was associated with linear growth at 1 y and no clear additional longitudinal effect from 1 to 5 y was observed. FM accretion showed a weak association from 1 to 5 y. This trial was registered at www.controlled-trials.com as ISRCTN46718296.

  15. Accretion Disks Around Binary Black Holes of Unequal Mass: GRMHD Simulations Near Decoupling

    Science.gov (United States)

    Gold, Roman; Paschalidis, Vasileios; Etienne, Zachariah B.; Shapiro, Stuart L.; Pfeiffer, Harald, P.

    2013-01-01

    We report on simulations in general relativity of magnetized disks onto black hole binaries. We vary the binary mass ratio from 1:1 to 1:10 and evolve the systems when they orbit near the binary disk decoupling radius. We compare (surface) density profiles, accretion rates (relative to a single, non-spinning black hole), variability, effective alpha-stress levels and luminosities as functions of the mass ratio. We treat the disks in two limiting regimes: rapid radiative cooling and no radiative cooling. The magnetic field lines clearly reveal jets emerging from both black hole horizons and merging into one common jet at large distances. The magnetic fields give rise to much stronger shock heating than the pure hydrodynamic flows, completely alter the disk structure, and boost accretion rates and luminosities. Accretion streams near the horizons are among the densest structures; in fact, the 1:10 no-cooling evolution results in a refilling of the cavity. The typical effective temperature in the bulk of the disk is approx. 10(exp5) (M / 10(exp 8)M solar mass (exp -1/4(L/L(sub edd) (exp 1/4K) yielding characteristic thermal frequencies approx. 10 (exp 15) (M /10(exp 8)M solar mass) (exp -1/4(L/L (sub edd) (1+z) (exp -1)Hz. These systems are thus promising targets for many extragalactic optical surveys, such as LSST, WFIRST, and PanSTARRS.

  16. The Eating Habits of Milky Way-mass Halos: Destroyed Dwarf Satellites and the Metallicity Distribution of Accreted Stars

    Science.gov (United States)

    Deason, Alis J.; Mao, Yao-Yuan; Wechsler, Risa H.

    2016-04-01

    We study the mass spectrum of destroyed dwarfs that contribute to the accreted stellar mass of Milky Way (MW)-mass (Mvir ˜ 1012.1 M⊙) halos using a suite of 45 zoom-in dissipationless simulations. Empirical models are employed to relate (peak) subhalo mass to dwarf stellar mass, and we use constraints from z = 0 observations and hydrodynamical simulations to estimate the metallicity distribution of the accreted stellar material. The dominant contributors to the accreted stellar mass are relatively massive dwarfs with Mstar ˜ 108-1010M⊙. Halos with more quiescent accretion histories tend to have lower mass progenitors (108-109 M⊙), and lower overall accreted stellar masses. Ultra-faint mass (Mstar 108 M⊙ can contribute a considerable fraction (˜20%-60%) of metal-poor stars if their metallicity distributions have significant metal-poor tails. Finally, we find that the generic assumption of a quiescent assembly history for the MW halo seems to be in tension with the mass spectrum of its surviving dwarfs. We suggest that the MW could be a “transient fossil” a quiescent halo with a recent accretion event(s) that disguises the preceding formation history of the halo.

  17. Does the mass of a black hole decrease due to the accretion of phantom energy?

    International Nuclear Information System (INIS)

    Gao Changjun; Chen Xuelei; Faraoni, Valerio; Shen Yougen

    2008-01-01

    According to Babichev et al., the accretion of a phantom test fluid onto a Schwarzschild black hole will induce the mass of the black hole to decrease, however the backreaction was ignored in their calculation. Using new exact solutions describing black holes in a background Friedmann-Robertson-Walker universe, we find that the physical black hole mass may instead increase due to the accretion of phantom energy. If this is the case, and the future universe is dominated by phantom dark energy, the black hole apparent horizon and the cosmic apparent horizon will eventually coincide and, after that, the black hole singularity will become naked in finite comoving time before the big rip occurs, violating the cosmic censorship conjecture.

  18. LOW-MASS AGNs AND THEIR RELATION TO THE FUNDAMENTAL PLANE OF BLACK HOLE ACCRETION

    Energy Technology Data Exchange (ETDEWEB)

    Gültekin, Kayhan; King, Ashley L.; Miller, Jon M. [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 48109 (United States); Cackett, Edward M. [Department of Physics and Astronomy, Wayne State University, 666 West Hancock Street, Detroit, MI 48201 (United States); Pinkney, Jason, E-mail: kayhan@umich.edu [Department of Physics and Astronomy, Ohio Northern University, 525 S. Main St., Ada, OH 45810 (United States)

    2014-06-20

    We put active galactic nuclei (AGNs) with low-mass black holes on the fundamental plane of black hole accretion—the plane that relates X-ray emission, radio emission, and mass of an accreting black hole—to test whether or not the relation is universal for both stellar-mass and supermassive black holes. We use new Chandra X-ray and Very Large Array radio observations of a sample of black holes with masses less than 10{sup 6.3} M {sub ☉}, which have the best leverage for determining whether supermassive black holes and stellar-mass black holes belong on the same plane. Our results suggest that the two different classes of black holes both belong on the same relation. These results allow us to conclude that the fundamental plane is suitable for use in estimating supermassive black hole masses smaller than ∼10{sup 7} M {sub ☉}, in testing for intermediate-mass black holes, and in estimating masses at high accretion rates.

  19. STABLE AND UNSTABLE REGIMES OF MASS ACCRETION ONTO RW AUR A

    Energy Technology Data Exchange (ETDEWEB)

    Takami, Michihiro; Wei, Yu-Jie; Chou, Mei-Yin; Karr, Jennifer L.; Liu, Hauyu Baobab [Institute of Astronomy and Astrophysics, Academia Sinica, 11F of Astronomy-Mathematics Building, AS/NTU, No.1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan, R.O.C. (China); Beck, Tracy L. [Space Telescope Science Institute, 3700 San Martin Dr., Baltimore, MD 21218 (United States); Manset, Nadine [Canada–France–Hawaii Telescope, 65-1238 Mamalahoa Hwy., Kamuela, HI 96743 (United States); Chen, Wen-Ping [Institute of Astronomy, National Central University, Taiwan 320, Taiwan (China); Kurosawa, Ryuichi [Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Fukagawa, Misato [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); White, Marc [Research School of Astronomy and Astrophysics, The Australian National University, Cotter Rd., Weston, ACT 2611 (Australia); Galván-Madrid, Roberto [Centro de Radioastronomía y Astrofísica, UNAM, Apdo. Postal 3-72 (Xangari), 58089 Morelia, Michoacán, México (Mexico); Pyo, Tae-Soo [Subaru Telescope, 650 North Aohoku Place, Hilo, HI 96720 (United States); Donati, Jean-Francois, E-mail: hiro@asiaa.snica.edu.tw [UPS-Toulouse/CNRS-INSU, Institut de Recherche en Astrophysique et Plańetologie (IRAP) UMR 5277, Toulouse F-31400 (France)

    2016-04-01

    We present monitoring observations of the active T Tauri star RW Aur, from 2010 October to 2015 January, using optical high-resolution (R ≥ 10,000) spectroscopy with Canada–France–Hawaii Telescope/ESPaDOnS. Optical photometry in the literature shows bright, stable fluxes over most of this period, with lower fluxes (by 2–3 mag) in 2010 and 2014. In the bright period our spectra show clear photospheric absorption, complicated variation in the Ca ii λ8542 emission profile shapes, and a large variation in redshifted absorption in the O i λλ7772 and 8446 and He i λ5876 lines, suggesting unstable mass accretion during this period. In contrast, these line profiles are relatively uniform during the faint periods, suggesting stable mass accretion. During the faint periods, the photospheric absorption lines are absent or marginal, and the averaged Li i profile shows redshifted absorption due to an inflow. We discuss (1) occultation by circumstellar material or a companion and (2) changes in the activity of mass accretion to explain the above results, together with near-infrared and X-ray observations from 2011 to 2015. Neither scenario can simply explain all the observed trends, and more theoretical work is needed to further investigate their feasibilities.

  20. UNDERSTANDING BLACK HOLE MASS ASSEMBLY VIA ACCRETION AND MERGERS AT LATE TIMES IN COSMOLOGICAL SIMULATIONS

    International Nuclear Information System (INIS)

    Kulier, Andrea; Ostriker, Jeremiah P.; Lackner, Claire N.; Cen, Renyue; Natarajan, Priyamvada

    2015-01-01

    Accretion is thought to primarily contribute to the mass accumulation history of supermassive black holes (SMBHs) throughout cosmic time. While this may be true at high redshifts, at lower redshifts and for the most massive black holes (BHs) mergers themselves might add significantly to the mass budget. We explore this in two disparate environments—a massive cluster and a void region. We evolve SMBHs from 4 > z > 0 using merger trees derived from hydrodynamical cosmological simulations of these two regions, scaled to the observed value of the stellar mass fraction to account for overcooling. Mass gains from gas accretion proportional to bulge growth and BH-BH mergers are tracked, as are BHs that remain ''orbiting'' due to insufficient dynamical friction in a merger remnant, as well as those that are ejected due to gravitational recoil. We find that gas accretion remains the dominant source of mass accumulation in almost all SMBHs; mergers contribute 2.5% ± 0.1% for all SMBHs in the cluster and 1.0% ± 0.1% in the void since z = 4. However, mergers are significant for massive SMBHs. The fraction of mass accumulated from mergers for central BHs generally increases for larger values of the host bulge mass: in the void, the fraction is 2% at M *, bul = 10 10 M ☉ , increasing to 4% at M *, bul ≳ 10 11 M ☉ , and in the cluster it is 4% at M *, bul = 10 10 M ☉ and 23% at 10 12 M ☉ . We also find that the total mass in orbiting SMBHs is negligible in the void, but significant in the cluster, in which a potentially detectable 40% of SMBHs and ≈8% of the total SMBH mass (where the total includes central, orbiting, and ejected SMBHs) is found orbiting at z = 0. The existence of orbiting and ejected SMBHs requires modification of the Soltan argument. We estimate this correction to the integrated accreted mass density of SMBHs to be in the range 6%-21%, with a mean value of 11% ± 3%. Quantifying the growth due to mergers at these late times

  1. Accretion of fat-free mass rather than fat mass in infancy is positively associated with linear growth in childhood

    DEFF Research Database (Denmark)

    Admassu Wossen, Bitiya; Ritz, Christian; Wells, Jonathan C K

    2018-01-01

    Background: We have previously shown that fat-free mass (FFM) at birth is associated with height at 2 y of age in Ethiopian children. However, to our knowledge, the relation between changes in body composition during early infancy and later linear growth has not been studied. Objective: This study...... examined the associations of early infancy fat mass (FM) and FFM accretion with linear growth from 1 to 5 y of age in Ethiopian children. Methods: In the infant Anthropometry and Body Composition (iABC) study, a prospective cohort study was carried out in children in Jimma, Ethiopia, followed from birth...... to 5 y of age. FM and FFM were measured ≤6 times from birth to 6 mo by using air-displacement plethysmography. Linear mixed-effects models were used to identify associations between standardized FM and FFM accretion rates during early infancy and linear growth from 1 to 5 y of age. Standardized...

  2. ACCURATE UNIVERSAL MODELS FOR THE MASS ACCRETION HISTORIES AND CONCENTRATIONS OF DARK MATTER HALOS

    International Nuclear Information System (INIS)

    Zhao, D. H.; Jing, Y. P.; Mo, H. J.; Boerner, G.

    2009-01-01

    A large amount of observations have constrained cosmological parameters and the initial density fluctuation spectrum to a very high accuracy. However, cosmological parameters change with time and the power index of the power spectrum dramatically varies with mass scale in the so-called concordance ΛCDM cosmology. Thus, any successful model for its structural evolution should work well simultaneously for various cosmological models and different power spectra. We use a large set of high-resolution N-body simulations of a variety of structure formation models (scale-free, standard CDM, open CDM, and ΛCDM) to study the mass accretion histories, the mass and redshift dependence of concentrations, and the concentration evolution histories of dark matter halos. We find that there is significant disagreement between the much-used empirical models in the literature and our simulations. Based on our simulation results, we find that the mass accretion rate of a halo is tightly correlated with a simple function of its mass, the redshift, parameters of the cosmology, and of the initial density fluctuation spectrum, which correctly disentangles the effects of all these factors and halo environments. We also find that the concentration of a halo is strongly correlated with the universe age when its progenitor on the mass accretion history first reaches 4% of its current mass. According to these correlations, we develop new empirical models for both the mass accretion histories and the concentration evolution histories of dark matter halos, and the latter can also be used to predict the mass and redshift dependence of halo concentrations. These models are accurate and universal: the same set of model parameters works well for different cosmological models and for halos of different masses at different redshifts, and in the ΛCDM case the model predictions match the simulation results very well even though halo mass is traced to about 0.0005 times the final mass, when

  3. AS ABOVE, SO BELOW: EXPLOITING MASS SCALING IN BLACK HOLE ACCRETION TO BREAK DEGENERACIES IN SPECTRAL INTERPRETATION

    International Nuclear Information System (INIS)

    Markoff, Sera; Silva, Catia V.; Nowak, Michael A.; Gallo, Elena; Plotkin, Richard M.; Hynes, Robert; Wilms, Jörn; Maitra, Dipankar; Drappeau, Samia

    2015-01-01

    Over the past decade, evidence has mounted that several aspects of black hole (BH) accretion physics proceed in a mass-invariant way. One of the best examples of this scaling is the empirical “fundamental plane of BH accretion” relation linking mass, radio, and X-ray luminosity over eight orders of magnitude in BH mass. The currently favored theoretical interpretation of this relation is that the physics governing power output in weakly accreting BHs depends more on relative accretion rate than on mass. In order to test this theory, we explore whether a mass-invariant approach can simultaneously explain the broadband spectral energy distributions from two BHs at opposite ends of the mass scale but that are at similar Eddington accretion fractions. We find that the same model, with the same value of several fitted physical parameters expressed in mass-scaling units to enforce self-similarity, can provide a good description of two data sets from V404 Cyg and M81*, a stellar and supermassive BH, respectively. Furthermore, only one of several potential emission scenarios for the X-ray band is successful, suggesting it is the dominant process driving the fundamental plane relation at this accretion rate. This approach thus holds promise for breaking current degeneracies in the interpretation of BH high-energy spectra and for constructing better prescriptions of BH accretion for use in various local and cosmological feedback applications

  4. THE EATING HABITS OF MILKY WAY-MASS HALOS: DESTROYED DWARF SATELLITES AND THE METALLICITY DISTRIBUTION OF ACCRETED STARS

    International Nuclear Information System (INIS)

    Deason, Alis J.; Mao, Yao-Yuan; Wechsler, Risa H.

    2016-01-01

    We study the mass spectrum of destroyed dwarfs that contribute to the accreted stellar mass of Milky Way (MW)-mass (M vir  ∼ 10 12.1 M ⊙ ) halos using a suite of 45 zoom-in dissipationless simulations. Empirical models are employed to relate (peak) subhalo mass to dwarf stellar mass, and we use constraints from z = 0 observations and hydrodynamical simulations to estimate the metallicity distribution of the accreted stellar material. The dominant contributors to the accreted stellar mass are relatively massive dwarfs with M star  ∼ 10 8 –10 10 M ⊙ . Halos with more quiescent accretion histories tend to have lower mass progenitors (10 8 –10 9 M ⊙ ), and lower overall accreted stellar masses. Ultra-faint mass (M star  < 10 5 M ⊙ ) dwarfs contribute a negligible amount (≪1%) to the accreted stellar mass and, despite having low average metallicities, supply a small fraction (∼2%–5%) of the very metal-poor stars with [Fe/H] < −2. Dwarfs with masses 10 5  < M star /M ⊙  < 10 8 provide a substantial amount of the very metal-poor stellar material (∼40%–80%), and even relatively metal-rich dwarfs with M star  > 10 8 M ⊙ can contribute a considerable fraction (∼20%–60%) of metal-poor stars if their metallicity distributions have significant metal-poor tails. Finally, we find that the generic assumption of a quiescent assembly history for the MW halo seems to be in tension with the mass spectrum of its surviving dwarfs. We suggest that the MW could be a “transient fossil”; a quiescent halo with a recent accretion event(s) that disguises the preceding formation history of the halo

  5. POISSON project. III. Investigating the evolution of the mass accretion rate

    Science.gov (United States)

    Antoniucci, S.; García López, R.; Nisini, B.; Caratti o Garatti, A.; Giannini, T.; Lorenzetti, D.

    2014-12-01

    Context. As part of the Protostellar Optical-Infrared Spectral Survey On NTT (POISSON) project, we present the results of the analysis of low-resolution near-IR spectroscopic data (0.9-2.4 μm) of two samples of young stellar objects in the Lupus (52 objects) and Serpens (17 objects) star-forming clouds, with masses in the range of 0.1 to 2.0 M⊙ and ages spanning from 105 to a few 107 yr. Aims: After determining the accretion parameters of the targets by analysing their H i near-IR emission features, we added the results from the Lupus and Serpens clouds to those from previous regions (investigated in POISSON with the same methodology) to obtain a final catalogue (143 objects) of mass accretion rate values (Ṁacc) derived in a homogeneous and consistent fashion. Our final goal is to analyse how Ṁacc correlates with the stellar mass (M∗) and how it evolves in time in the whole POISSON sample. Methods: We derived the accretion luminosity (Lacc) and Ṁacc for Lupus and Serpens objects from the Brγ (Paβ in a few cases) line by using relevant empirical relationships available in the literature that connect the H i line luminosity and Lacc. To minimise the biases that arise from adopting literature data that are based on different evolutionary models and also for self-consistency, we re-derived mass and age for each source of the POISSON samples using the same set of evolutionary tracks. Results: We observe a correlation Ṁacc~M*2.2 between mass accretion rate and stellar mass, similarly to what has previously been observed in several star-forming regions. We find that the time variation of Ṁacc is roughly consistent with the expected evolution of the accretion rate in viscous disks, with an asymptotic decay that behaves as t-1.6. However, Ṁacc values are characterised by a large scatter at similar ages and are on average higher than the predictions of viscous models. Conclusions: Although part of the scattering may be related to systematics due to the

  6. Muscle strength rather than muscle mass is associated with osteoporosis in older Chinese adults

    Directory of Open Access Journals (Sweden)

    Yixuan Ma

    2018-02-01

    Conclusion: Based on our study, muscle strength rather than muscle mass is negatively associated with OS in older people; thus, we should pay more attention to muscle strength training in the early stage of the OS.

  7. Mergers and mass accretion for infalling halos both end well outside cluster virial radii

    Energy Technology Data Exchange (ETDEWEB)

    Behroozi, Peter S.; Wechsler, Risa H.; Lu, Yu; Hahn, Oliver; Busha, Michael T.; Klypin, Anatoly; Primack, Joel R.

    2014-05-14

    We find that infalling dark matter halos (i.e., the progenitors of satellite halos) begin losing mass well outside the virial radius of their eventual host halos. The peak mass occurs at a range of clustercentric distances, with median and 68th percentile range of $1.8^{+2.3}_{-1.0} \\,R_\\mathrm{vir,host}$ for progenitors of z = 0 satellites. The peak circular velocity for infalling halos occurs at significantly larger distances ($3.7^{+3.3}_{-2.2} \\,R_\\mathrm{vir,host}$ at z = 0). This difference arises because different physical processes set peak circular velocity (typically, ~1:5 and larger mergers which cause transient circular velocity spikes) and peak mass (typically, smooth accretion) for infalling halos. We find that infalling halos also stop having significant mergers well before they enter the virial radius of their eventual hosts. Mergers larger than a 1:40 ratio in halo mass end for infalling halos at similar clustercentric distances (~1.9 R vir, host) as the end of overall mass accretion. However, mergers larger than 1:3 typically end for infalling halos at more than four virial radial away from their eventual hosts. This limits the ability of mergers to affect quenching and morphology changes in clusters. We also note that the transient spikes which set peak circular velocity may lead to issues with abundance matching on that parameter, including unphysical galaxy stellar mass growth profiles near clusters; we propose a simple observational test to check if a better halo proxy for galaxy stellar mass exists.

  8. A High-mass Protobinary System with Spatially Resolved Circumstellar Accretion Disks and Circumbinary Disk

    Energy Technology Data Exchange (ETDEWEB)

    Kraus, S.; Kluska, J.; Kreplin, A.; Bate, M.; Harries, T. J.; Hone, E.; Anugu, A. [School of Physics, Astrophysics Group, University of Exeter, Stocker Road, Exeter EX4 4QL (United Kingdom); Hofmann, K.-H.; Weigelt, G. [Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Monnier, J. D. [Department of Astronomy, University of Michigan, 311 West Hall, 1085 South University Avenue, Ann Arbor, MI 48109 (United States); De Wit, W. J. [ESO, Alonso de Cordova 3107, Vitacura, Santiago 19 (Chile); Wittkowski, M., E-mail: skraus@astro.ex.ac.uk [ESO, Karl-Schwarzschild-Str. 2, D-85748 Garching bei München (Germany)

    2017-01-20

    High-mass multiples might form via fragmentation of self-gravitational disks or alternative scenarios such as disk-assisted capture. However, only a few observational constraints exist on the architecture and disk structure of high-mass protobinaries and their accretion properties. Here, we report the discovery of a close (57.9 ± 0.2 mas = 170 au) high-mass protobinary, IRAS17216-3801, where our VLTI/GRAVITY+AMBER near-infrared interferometry allows us to image the circumstellar disks around the individual components with ∼3 mas resolution. We estimate the component masses to ∼20 and ∼18 M {sub ⊙} and find that the radial intensity profiles can be reproduced with an irradiated disk model, where the inner regions are excavated of dust, likely tracing the dust sublimation region in these disks. The circumstellar disks are strongly misaligned with respect to the binary separation vector, which indicates that the tidal forces did not have time to realign the disks, pointing toward a young dynamical age of the system. We constrain the distribution of the Br γ and CO-emitting gas using VLTI/GRAVITY spectro-interferometry and VLT/CRIRES spectro-astrometry and find that the secondary is accreting at a higher rate than the primary. VLT/NACO imaging shows L ′-band emission on (3–4)× larger scales than the binary separation, matching the expected dynamical truncation radius for the circumbinary disk. The IRAS17216-3801 system is ∼3× more massive and ∼5× more compact than other high-mass multiplies imaged at infrared wavelength and the first high-mass protobinary system where circumstellar and circumbinary dust disks could be spatially resolved. This opens exciting new opportunities for studying star–disk interactions and the role of multiplicity in high-mass star formation.

  9. Mergers and mass accretion for infalling halos both end well outside cluster virial radii

    Energy Technology Data Exchange (ETDEWEB)

    Behroozi, Peter S. [Space Telescope Science Institute, Baltimore, MD 21218 (United States); Wechsler, Risa H.; Lu, Yu; Busha, Michael T. [Physics Department, Stanford University, Department of Particle and Particle Astrophysics, SLAC National Accelerator Laboratory, Kavli Institute for Particle Astrophysics and Cosmology Stanford, CA 94305 (United States); Hahn, Oliver [Institute for Astronomy, ETH Zurich, 8093-CH Zurich (Switzerland); Klypin, Anatoly [Astronomy Department, New Mexico State University, Las Cruces, NM 88003 (United States); Primack, Joel R., E-mail: behroozi@stsci.edu [Department of Physics, University of California at Santa Cruz, Santa Cruz, CA 95064 (United States)

    2014-06-01

    We find that infalling dark matter halos (i.e., the progenitors of satellite halos) begin losing mass well outside the virial radius of their eventual host halos. The peak mass occurs at a range of clustercentric distances, with median and 68th percentile range of 1.8{sub −1.0}{sup +2.3} R{sub vir,host} for progenitors of z = 0 satellites. The peak circular velocity for infalling halos occurs at significantly larger distances (3.7{sub −2.2}{sup +3.3} R{sub vir,host} at z = 0). This difference arises because different physical processes set peak circular velocity (typically, ∼1:5 and larger mergers which cause transient circular velocity spikes) and peak mass (typically, smooth accretion) for infalling halos. We find that infalling halos also stop having significant mergers well before they enter the virial radius of their eventual hosts. Mergers larger than a 1:40 ratio in halo mass end for infalling halos at similar clustercentric distances (∼1.9 R {sub vir,} {sub host}) as the end of overall mass accretion. However, mergers larger than 1:3 typically end for infalling halos at more than four virial radial away from their eventual hosts. This limits the ability of mergers to affect quenching and morphology changes in clusters. We also note that the transient spikes which set peak circular velocity may lead to issues with abundance matching on that parameter, including unphysical galaxy stellar mass growth profiles near clusters; we propose a simple observational test to check if a better halo proxy for galaxy stellar mass exists.

  10. Mergers and mass accretion for infalling halos both end well outside cluster virial radii

    International Nuclear Information System (INIS)

    Behroozi, Peter S.; Wechsler, Risa H.; Lu, Yu; Busha, Michael T.; Hahn, Oliver; Klypin, Anatoly; Primack, Joel R.

    2014-01-01

    We find that infalling dark matter halos (i.e., the progenitors of satellite halos) begin losing mass well outside the virial radius of their eventual host halos. The peak mass occurs at a range of clustercentric distances, with median and 68th percentile range of 1.8 −1.0 +2.3 R vir,host for progenitors of z = 0 satellites. The peak circular velocity for infalling halos occurs at significantly larger distances (3.7 −2.2 +3.3 R vir,host at z = 0). This difference arises because different physical processes set peak circular velocity (typically, ∼1:5 and larger mergers which cause transient circular velocity spikes) and peak mass (typically, smooth accretion) for infalling halos. We find that infalling halos also stop having significant mergers well before they enter the virial radius of their eventual hosts. Mergers larger than a 1:40 ratio in halo mass end for infalling halos at similar clustercentric distances (∼1.9 R vir, host ) as the end of overall mass accretion. However, mergers larger than 1:3 typically end for infalling halos at more than four virial radial away from their eventual hosts. This limits the ability of mergers to affect quenching and morphology changes in clusters. We also note that the transient spikes which set peak circular velocity may lead to issues with abundance matching on that parameter, including unphysical galaxy stellar mass growth profiles near clusters; we propose a simple observational test to check if a better halo proxy for galaxy stellar mass exists.

  11. The White Dwarf Mass and the Accretion Rate of Recurrent Novae: An X-ray Perspective

    Science.gov (United States)

    Mukai, Koji; Sokoloski, Jennifer L.; Nelson, Thomas; Luna, Gerardo J. M.

    2011-01-01

    We present recent results of quiescent X-ray observations of recurrent novae (RNe) and related objects. Several RNe are luminous hard X-ray sources in quiescence, consistent with accretion onto a near Chandrasekhar mass white dwarf. Detection of similar hard X-ray emissions in old novae and other cataclysmic variables may lead to identification of additional RN candidates. On the other hand, other RNe are found to be comparatively hard X-ray faint. We present several scenarios that may explain this dichotomy, which should be explored further.

  12. Muscle Mass and Weight Gain Nutritional Supplements

    Science.gov (United States)

    Campbell, Bill

    There are numerous sports supplements available that claim to increase lean body mass. However, for these sports supplements to exert any favorable changes in lean body mass, they must influence those factors regulating skeletal muscle hypertrophy (i.e., satellite cell activity, gene transcription, protein translation). If a given sports supplement does favorably influence one of these regulatory factors, the result is a positive net protein balance (in which protein synthesis exceeds protein breakdown). Sports supplement categories aimed at eliciting a positive net protein balance include anabolic hormone enhancers, nutrient timing pre- and postexercise workout supplements, anticatabolic supplements, and nitric oxide boosters. Of all the sports supplements available, only a few have been subject to multiple clinical trials with repeated favorable outcomes relative to increasing lean body mass. This chapter focuses on these supplements and others that have a sound theoretical rationale in relation to increasing lean body mass.

  13. Effects of local thermodynamics and of stellar mass ratio on accretion disc stability in close binaries

    Science.gov (United States)

    Lanzafame, G.

    2009-08-01

    Inflow kinematics at the inner Lagrangian point L1, gas compressibility, and physical turbulent viscosity play a fundamental role on accretion disc dynamics and structure in a close binary (CB). Physical viscosity supports the accretion disc development inside the primary gravitational potential well, developing the gas radial transport, converting mechanical energy into heat. The Stellar-Mass-Ratio (SMR) between the compact primary and the secondary star (M1/M2) is also effective, not only in the location of the inner Lagrangian point, but also in the angular kinematics of the mass transfer and in the geometry of the gravitational potential wells. In this work we pay attention in particular to the role of the SMR, evaluating boundaries, separating theoretical domains in compressibility-viscosity graphs where physical conditions allow a well-bound disc development, as a function of mass transfer kinematic conditions. In such domains, the lower is the gas compressibility (the higher the polytropic index γ), the higher is the physical viscosity (α) requested. In this work, we show how the boundaries of such domains vary as a function of M1/M2. Conclusions as far as dwarf novae outbursts are concerned, induced by mass transfer rate variations, are also reported. The smaller M1/M2, the shorter the duration of the active-to-quiet and vice-versa transitional phases. Time-scales are of the order of outburst duration of SU Uma, OY Car, Z Cha and SS Cyg-like objects. Moreover, conclusions as far as active-quiet-active phenomena in a CB, according to viscous-thermal instabilities, in accordance to such domains, are also reported.

  14. EDDINGTON-LIMITED ACCRETION AND THE BLACK HOLE MASS FUNCTION AT REDSHIFT 6

    International Nuclear Information System (INIS)

    Willott, Chris J.; Crampton, David; Hutchings, John B.; Schade, David; Albert, Loic; Arzoumanian, Doris; Bergeron, Jacqueline; Omont, Alain; Delorme, Philippe; Reyle, Celine

    2010-01-01

    We present discovery observations of a quasar in the Canada-France High-z Quasar Survey (CFHQS) at redshift z = 6.44. We also use near-infrared spectroscopy of nine CFHQS quasars at z ∼ 6 to determine black hole masses. These are compared with similar estimates for more luminous Sloan Digital Sky Survey quasars to investigate the relationship between black hole mass and quasar luminosity. We find a strong correlation between Mg II FWHM and UV luminosity and that most quasars at this early epoch are accreting close to the Eddington limit. Thus, these quasars appear to be in an early stage of their life cycle where they are building up their black hole mass exponentially. Combining these results with the quasar luminosity function, we derive the black hole mass function at z = 6. Our black hole mass function is ∼10 4 times lower than at z = 0 and substantially below estimates from previous studies. The main uncertainties which could increase the black hole mass function are a larger population of obscured quasars at high redshift than is observed at low redshift and/or a low quasar duty cycle at z = 6. In comparison, the global stellar mass function is only ∼10 2 times lower at z = 6 than at z = 0. The difference between the black hole and stellar mass function evolution is due to either rapid early star formation which is not limited by radiation pressure as is the case for black hole growth or inefficient black hole seeding. Our work predicts that the black hole mass-stellar mass relation for a volume-limited sample of galaxies declines rapidly at very high redshift. This is in contrast to the observed increase at 4 < z < 6 from the local relation if one just studies the most massive black holes.

  15. Helium-burning flashes on accreting neutron stars: effects of stellar mass, radius, and magnetic field

    International Nuclear Information System (INIS)

    Joss, P.C.; Li, F.K.

    1980-01-01

    We have computed the evolution of the helium-burning shell in an accreting neutron star for various values of the stellar mass (M), radius (R), and surface magnetic fields strength (B). As shown in previous work, the helium-burning shell is often unstable and undergoes thermonuclear flashes that result in the emission of X-ray bursts from the neutron-star surface. The dependence of the properties of these bursts upon the values of M and R can be described by simple scaling relations. A strong magnetic field decreases the radiative and conductive opacities and inhibits convection in the neutron-star surface layers. For B 12 gauss, these effects are unimportant; for B> or approx. =10 13 gauss, the enhancement of the electron thermal conductivity is sufficiently large to stabilize the helium-burning shell against thermonuclear flashes. For intermediate values of B, the reduced opacities increase the recurrence intervals between bursts and the energy released per burst, while the inhibition of convection increases the burst rise times to about a few seconds. If the magnetic field funnels the accreting matter onto the magnetic polar caps, the instability of the helium-burning shell will be very strongly suppressed. These results suggest that it may eventually be possible to extract information on the macroscopic properties of neutron stars from the observed features of X-ray burst sources

  16. Modelling hard and soft states of Cygnus X-1 with propagating mass accretion rate fluctuations

    Science.gov (United States)

    Rapisarda, S.; Ingram, A.; van der Klis, M.

    2017-12-01

    We present a timing analysis of three Rossi X-ray Timing Explorer observations of the black hole binary Cygnus X-1 with the propagating mass accretion rate fluctuations model PROPFLUC. The model simultaneously predicts power spectra, time lags and coherence of the variability as a function of energy. The observations cover the soft and hard states of the source, and the transition between the two. We find good agreement between model predictions and data in the hard and soft states. Our analysis suggests that in the soft state the fluctuations propagate in an optically thin hot flow extending up to large radii above and below a stable optically thick disc. In the hard state, our results are consistent with a truncated disc geometry, where the hot flow extends radially inside the inner radius of the disc. In the transition from soft to hard state, the characteristics of the rapid variability are too complex to be successfully described with PROPFLUC. The surface density profile of the hot flow predicted by our model and the lack of quasi-periodic oscillations in the soft and hard states suggest that the spin of the black hole is aligned with the inner accretion disc and therefore probably with the rotational axis of the binary system.

  17. Mass Flux and Terminal Velocities of Magnetically Driven Jets from Accretion Disks

    Science.gov (United States)

    Kudoh, Takahiro; Shibata, Kazunari

    1995-10-01

    In order to investigate astrophysical jets from accretion disks, we solve 1.5-dimensional steady MHD equations for a wide range of parameters, assuming the shape of poloidal magnetic field lines. We include a thermal effect to obtain the relation between the mass flux of the jet and the magnetic energy at the disk, although the jet is mainly accelerated by the magnetic force. It is found that the mass flux of the jets ( M dot ) is dependent on the magnetic energy at the disk surface, i.e., M dot ~ (rho Aa|Bp/B|)_{{slow}} ~ (rho Aa|Bp/Bphi|)_{{slow}} ~ Ealpha_{{mg}} [where rho is the density, a is the sound velocity, A is the cross section of the magnetic flux, B = (B2p + B2phi)^{1/2} , Bp and B phi are the poloidal and toroidal magnetic field strength, respectively, Emg is the magnetic energy in unit of the gravitational energy at the disk surface, and the suffix "slow" denotes the value at a slow point], when the magnetic energy is not too large. The parameter alpha increases from 0 to 0.5 with decreasing magnetic energy. Since the scaling law of Michel's minimum energy solution nearly holds in the magnetically driven flows, the dependence of the terminal velocity on the magnetic energy becomes weaker than had been expected, i.e., v_∞ ~ E^{(1-alpha)/3}_{{mg}} . It is shown that the terminal velocity of the jet is an order of Keplerian velocity at the footpoint of the jets for a wide range of values of Emg expected for accretion disks in star-forming regions and active galactic nuclei. We argue that the mass-loss rates observed in the star-forming regions would constrain the magnetic energies at the disk surfaces.

  18. THE EATING HABITS OF MILKY WAY-MASS HALOS: DESTROYED DWARF SATELLITES AND THE METALLICITY DISTRIBUTION OF ACCRETED STARS

    Energy Technology Data Exchange (ETDEWEB)

    Deason, Alis J.; Mao, Yao-Yuan; Wechsler, Risa H., E-mail: adeason@stanford.edu [Kavli Institute for Particle Astrophysics and Cosmology and Physics Department, Stanford University, Stanford, CA 94305 (United States)

    2016-04-10

    We study the mass spectrum of destroyed dwarfs that contribute to the accreted stellar mass of Milky Way (MW)-mass (M{sub vir} ∼ 10{sup 12.1} M{sub ⊙}) halos using a suite of 45 zoom-in dissipationless simulations. Empirical models are employed to relate (peak) subhalo mass to dwarf stellar mass, and we use constraints from z = 0 observations and hydrodynamical simulations to estimate the metallicity distribution of the accreted stellar material. The dominant contributors to the accreted stellar mass are relatively massive dwarfs with M{sub star} ∼ 10{sup 8}–10{sup 10}M{sub ⊙}. Halos with more quiescent accretion histories tend to have lower mass progenitors (10{sup 8}–10{sup 9} M{sub ⊙}), and lower overall accreted stellar masses. Ultra-faint mass (M{sub star} < 10{sup 5} M{sub ⊙}) dwarfs contribute a negligible amount (≪1%) to the accreted stellar mass and, despite having low average metallicities, supply a small fraction (∼2%–5%) of the very metal-poor stars with [Fe/H] < −2. Dwarfs with masses 10{sup 5} < M{sub star}/M{sub ⊙} < 10{sup 8} provide a substantial amount of the very metal-poor stellar material (∼40%–80%), and even relatively metal-rich dwarfs with M{sub star} > 10{sup 8} M{sub ⊙} can contribute a considerable fraction (∼20%–60%) of metal-poor stars if their metallicity distributions have significant metal-poor tails. Finally, we find that the generic assumption of a quiescent assembly history for the MW halo seems to be in tension with the mass spectrum of its surviving dwarfs. We suggest that the MW could be a “transient fossil”; a quiescent halo with a recent accretion event(s) that disguises the preceding formation history of the halo.

  19. Carbohydrate co-ingestion with protein does not further augment post-prandial muscle protein accretion in older men

    Directory of Open Access Journals (Sweden)

    Hamer Henrike M

    2013-01-01

    Full Text Available Abstract Background A blunted muscle protein synthetic response to protein ingestion may contribute to the age related loss of muscle tissue. We hypothesized that the greater endogenous insulin release following co-ingestion of carbohydrate facilitates post-prandial muscle protein accretion after ingesting a meal-like bolus of protein in older males. Methods Twenty-four healthy older men (75±1 y were randomly assigned to ingest 20 g intrinsically L-[1-13C] phenylalanine-labeled casein protein with (PRO-CHO or without (PRO 40 g carbohydrate. Ingestion of specifically produced intrinsically L-[1-13C] phenylalanine labeled protein allowed us to assess post-prandial incorporation of dietary protein derived amino acids into muscle protein. Blood samples were collected at regular intervals, with muscle biopsies being obtained prior to and 2 and 6 h after protein ingestion. Results Plasma glucose and insulin concentrations showed a greater increase in PRO-CHO compared with PRO (P13C] phenylalanine enrichments tended to increase to a greater extent in PRO-CHO compared with PRO during the first 2 h after protein ingestion (0.0072±0.0013 vs 0.0046±0.010 MPE, respectively; P=0.13. However, 6 h after protein ingestion, differences in muscle protein-bound L-[1-13C] phenylalanine enrichments were no longer observed between experiments (0.0213±0.0024 vs 0.0185±0.0010 MPE, respectively; P=0.30. Conclusions This study shows that carbohydrate ingestion may accelerate, but does not further augment post-prandial incorporation of dietary protein derived amino acids into muscle protein in healthy elderly men.

  20. Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass

    Science.gov (United States)

    Davey, Jonathan R.; Watt, Kevin I.; Parker, Benjamin L.; Chaudhuri, Rima; Ryall, James G.; Cunningham, Louise; Qian, Hongwei; Sartorelli, Vittorio; Chamberlain, Jeffrey; James, David E.

    2016-01-01

    The transforming growth factor-β (TGF-β) signaling network is a critical regulator of skeletal muscle mass and function and, thus, is an attractive therapeutic target for combating muscle disease, but the underlying mechanisms of action remain undetermined. We report that follistatin-based interventions (which modulate TGF-β network activity) can promote muscle hypertrophy that ameliorates aging-associated muscle wasting. However, the muscles of old sarcopenic mice demonstrate reduced response to follistatin compared with healthy young-adult musculature. Quantitative proteomic and transcriptomic analyses of young-adult muscles identified a transcription/translation signature elicited by follistatin exposure, which included repression of ankyrin repeat and SOCS box protein 2 (Asb2). Increasing expression of ASB2 reduced muscle mass, thereby demonstrating that Asb2 is a TGF-β network–responsive negative regulator of muscle mass. In contrast to young-adult muscles, sarcopenic muscles do not exhibit reduced ASB2 abundance with follistatin exposure. Moreover, preventing repression of ASB2 in young-adult muscles diminished follistatin-induced muscle hypertrophy. These findings provide insight into the program of transcription and translation events governing follistatin-mediated adaptation of skeletal muscle attributes and identify Asb2 as a regulator of muscle mass implicated in the potential mechanistic dysfunction between follistatin-mediated muscle growth in young and old muscles. PMID:27182554

  1. GALAXY FORMATION WITH COLD GAS ACCRETION AND EVOLVING STELLAR INITIAL MASS FUNCTION

    International Nuclear Information System (INIS)

    Kang Xi; Lin, W. P.; Skibba, Ramin; Chen, D. N.

    2010-01-01

    The evolution of the galaxy stellar mass function is especially useful to test the current model of galaxy formation. Observational data have revealed a few inconsistencies with predictions from the ΛCDM model. For example, most massive galaxies have already been observed at very high redshifts, and they have experienced only mild evolution since then. In conflict with this, semi-analytical models (SAMs) of galaxy formation predict an insufficient number of massive galaxies at high redshift and a rapid evolution between redshift 1 and 0. In addition, there is a strong correlation between star formation rate (SFR) and stellar mass for star-forming galaxies, which can be roughly reproduced with the model, but with a normalization that is too low at high redshift. Furthermore, the stellar mass density obtained from the integral of the cosmic star formation history is higher than the measured one by a factor of 2. In this paper, we study these issues using an SAM that includes (1) cold gas accretion in massive halos at high redshift; (2) tidal stripping of stellar mass from satellite galaxies; and (3) an evolving stellar initial mass function (IMF; bottom-light) with a higher gas recycle fraction. Our results show that the combined effects from (1) and (2) can predict sufficiently massive galaxies at high redshifts and reproduce their mild evolution at low redshift, while the combined effects of (1) and (3) can reproduce the correlation between SFR and stellar mass for star-forming galaxies across a wide range of redshifts. A bottom-light/top-heavy stellar IMF could partly resolve the conflict between the stellar mass density and cosmic star formation history.

  2. Muscle Strength and Muscle Mass in Older Patients during Hospitalization: The EMPOWER Study

    Science.gov (United States)

    Van Ancum, Jeanine M.; Scheerman, Kira; Pierik, Vincent D.; Numans, Siger T.; Verlaan, Sjors; Smeenk, Hanne E.; Slee-Valentijn, Monique; Kruizinga, Roeliene C.; Meskers, Carel G.M.; Maier, Andrea B.

    2017-01-01

    Background Low muscle strength and muscle mass are associated with an increased length of hospital stay and higher mortality rate in inpatients. To what extent hospitalization affects muscle strength and muscle mass is unclear. Objective We aimed to assess muscle strength and muscle mass at admission and during hospitalization in older patients and its relation with being at risk of geriatric conditions. Methods The EMPOWER study included patients aged 70 years and older, admitted to 4 wards of the VU University Medical Center in the Netherlands between April and December 2015. At admission, patients were screened for being at risk of 4 geriatric conditions: delirium, falls, malnutrition, and functional disability. At admission and at discharge, muscle strength and muscle mass were assessed. Results A total of 373 patients (mean age, standard deviation [SD]: 79.6, 6.38 years) were included at admission, and 224 patients (mean age, SD: 80.1, 6.32 years) at discharge. At admission, lower muscle strength in both female and male patients and low muscle mass in male patients were associated with being at risk of a higher cumulative number of geriatric conditions. Muscle strength increased during hospitalization, but no change in muscle mass was observed. Changes in muscle measures were not associated with being at risk of geriatric conditions. Discussion Older patients with lower muscle strength and muscle mass at admission were at risk of a higher cumulative number of geriatric conditions. However, being at risk of geriatric conditions did not forecast further decrease in muscle strength and muscle mass during hospitalization PMID:28817825

  3. EVOLUTIONARY TRACKS OF TRAPPED, ACCRETING PROTOPLANETS: THE ORIGIN OF THE OBSERVED MASS-PERIOD RELATION

    International Nuclear Information System (INIS)

    Hasegawa, Yasuhiro; Pudritz, Ralph E.

    2012-01-01

    The large number of observed exoplanets (∼>700) provides important constraints on their origin as deduced from the mass-period diagram of planets. The most surprising features in the diagram are (1) the (apparent) pileup of gas giants at a period of ∼500 days (∼1 AU) and (2) the so-called mass-period relation, which indicates that planetary mass is an increasing function of orbital period. We construct the evolutionary tracks of growing planets at planet traps in evolving protoplanetary disks and show that they provide a good physical understanding of how these observational properties arise. The fundamental feature of our model is that inhomogeneities in protoplanetary disks give rise to multiple (up to 3) trapping sites for rapid (type I) planetary migration of planetary cores. The viscous evolution of disks results in the slow radial movement of the traps and their cores from large to small orbital periods. In our model, the slow inward motion of planet traps is coupled with the standard core accretion scenario for planetary growth. As planets grow, type II migration takes over. Planet growth and radial movement are ultimately stalled by the dispersal of gas disks via photoevaporation. Our model makes a number of important predictions: that distinct sub-populations of planets that reflect the properties of planet traps where they have grown result in the mass-period relation, that the presence of these sub-populations naturally explains a pileup of planets at ∼1 AU, and that evolutionary tracks from the ice line do put planets at short periods and fill an earlier claimed p lanet desert — a sparse population of planets in the mass-semimajor axis diagram.

  4. CORRELATIONS BETWEEN MUSCLE MASS, MUSCLE STRENGTH, PHYSICAL PERFORMANCE, AND MUSCLE FATIGUE RESISTANCE IN COMMUNITY-DWELLING ELDERLY SUBJECTS

    Directory of Open Access Journals (Sweden)

    Elizabeth

    2016-03-01

    Full Text Available Objective: To determine the correlations between muscle mass, muscle strength, physical performance, and muscle fatigue resistance in community-dwelling elderly people in order to elucidate factors which contribute to elderly’s performance of daily activities. Methods: A cross-sectional study was conducted on community-dwelling elderly in Bandung from September to December 2014. One hundred and thirty elderly, 60 years old or above, were evaluated using bioelectrical impedance analysis to measure muscle mass; grip strength to measure muscle strength and muscle fatigue resistance; habitual gait speed to measure physical performance; and Global Physical Activity Questionnaire (GPAQ to assess physical activity. Results: There were significant positive correlations between muscle mass (r=0,27, p=0,0019, muscle strength (r=0,26, p=0,0024, and physical performance (r=0,32, p=0,0002 with muscle fatigue resistance. Physical performance has the highest correlation based on multiple regression test (p=0,0025. In association with muscle mass, the physical activity showed a significant positive correlation (r=0,42, p=0,0000. Sarcopenia was identified in 19 (14.61% of 130 subjects. Conclusions: It is suggested that muscle mass, muscle strength, and physical performance influence muscle fatigue resistance.

  5. : Nuclear Spirals and Mass Accretion to Supermassive Black Holes in Weakly-Barred Galaxies

    Science.gov (United States)

    Kim, Woong-Tae; Elmegreen, Bruce

    2018-01-01

    Disk galaxies, especially barred-spiral galaxies, abound with rings and spirals in their nuclear regions. Nuclear spirals existing even in weakly barred galaxies are thought to channel gas inflows to supermassive black holes residing at the centers. We use high-resolution hydrodynamic simulations to study the properties of nuclear gas spirals driven by weak bar-like or oval potentials. The amplitude of the spirals increases toward the center by a geometric effect, readily developing into shocks at small radii even for very weak potentials. The shape of the spirals and shocks depends rather sensitively on the background shear. When shear is low, the nuclear spirals are loosely wound and the shocks are almost straight, resulting in large mass inflows toward the center. When shear is high, on the other hand, the spirals are tightly wound and the shocks are oblique, forming a circumnuclear disk through which gas flows inward at a relatively lower rate. The induced mass inflow rates are enough to power black hole accretion in various types of Seyfert galaxies.

  6. Chronic exercise preserves lean muscle mass in masters athletes.

    Science.gov (United States)

    Wroblewski, Andrew P; Amati, Francesca; Smiley, Mark A; Goodpaster, Bret; Wright, Vonda

    2011-09-01

    Aging is commonly associated with a loss of muscle mass and strength, resulting in falls, functional decline, and the subjective feeling of weakness. Exercise modulates the morbidities of muscle aging. Most studies, however, have examined muscle-loss changes in sedentary aging adults. This leaves the question of whether the changes that are commonly associated with muscle aging reflect the true physiology of muscle aging or whether they reflect disuse atrophy. This study evaluated whether high levels of chronic exercise prevents the loss of lean muscle mass and strength experienced in sedentary aging adults. A cross-section of 40 high-level recreational athletes ("masters athletes") who were aged 40 to 81 years and trained 4 to 5 times per week underwent tests of health/activity, body composition, quadriceps peak torque (PT), and magnetic resonance imaging of bilateral quadriceps. Mid-thigh muscle area, quadriceps area (QA), subcutaneous adipose tissue, and intramuscular adipose tissue were quantified in magnetic resonance imaging using medical image processing, analysis, and visualization software. One-way analysis of variance was used to examine age group differences. Relationships were evaluated using Spearman correlations. Mid-thigh muscle area (P = 0.31) and lean mass (P = 0.15) did not increase with age and were significantly related to retention of mid-thigh muscle area (P lean mass (P = 0.4) and PT. This study contradicts the common observation that muscle mass and strength decline as a function of aging alone. Instead, these declines may signal the effect of chronic disuse rather than muscle aging. Evaluation of masters athletes removes disuse as a confounding variable in the study of lower-extremity function and loss of lean muscle mass. This maintenance of muscle mass and strength may decrease or eliminate the falls, functional decline, and loss of independence that are commonly seen in aging adults.

  7. PRIMUS: THE DEPENDENCE OF AGN ACCRETION ON HOST STELLAR MASS AND COLOR

    Energy Technology Data Exchange (ETDEWEB)

    Aird, James; Coil, Alison L.; Moustakas, John; Smith, M. Stephen M. [Center for Astrophysics and Space Sciences, Department of Physics, University of California, 9500 Gilman Dr., La Jolla, San Diego, CA 92093 (United States); Blanton, Michael R.; Zhu Guangtun [Center for Cosmology and Particle Physics, Department of Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); Burles, Scott M. [D.E. Shaw and Co., L.P., 20400 Stevens Creek Blvd., Suite 850, Cupertino, CA 95014 (United States); Cool, Richard J. [Department of Astrophysical Sciences, Princeton University, Peyton Hall, Princeton, NJ 08544 (United States); Eisenstein, Daniel J. [Harvard College Observatory, 60 Garden St., Cambridge, MA 02138 (United States); Wong, Kenneth C. [Steward Observatory, University of Arizona, 933 N. Cherry Ave., Tucson, AZ 85721 (United States)

    2012-02-10

    We present evidence that the incidence of active galactic nuclei (AGNs) and the distribution of their accretion rates do not depend on the stellar masses of their host galaxies, contrary to previous studies. We use hard (2-10 keV) X-ray data from three extragalactic fields (XMM-LSS, COSMOS, and ELAIS-S1) with redshifts from the Prism Multi-object Survey to identify 242 AGNs with L{sub 2-10keV} = 10{sup 42-44} erg s{sup -1} within a parent sample of {approx}25,000 galaxies at 0.2 < z < 1.0 over {approx}3.4 deg{sup 2} and to i {approx} 23. We find that although the fraction of galaxies hosting an AGN at fixed X-ray luminosity rises strongly with stellar mass, the distribution of X-ray luminosities is independent of mass. Furthermore, we show that the probability that a galaxy will host an AGN can be defined by a universal Eddington ratio distribution that is independent of the host galaxy stellar mass and has a power-law shape with slope -0.65. These results demonstrate that AGNs are prevalent at all stellar masses in the range 9.5< log M{sub *}/M{sub sun}<12 and that the same physical processes regulate AGN activity in all galaxies in this stellar mass range. While a higher AGN fraction may be observed in massive galaxies, this is a selection effect related to the underlying Eddington ratio distribution. We also find that the AGN fraction drops rapidly between z {approx} 1 and the present day and is moderately enhanced (factor {approx}2) in galaxies with blue or green optical colors. Consequently, while AGN activity and star formation appear to be globally correlated, we do not find evidence that the presence of an AGN is related to the quenching of star formation or the color transformation of galaxies.

  8. Mass accretion and nested array dynamics from Ni-Clad Ti-Al wire array Z pinches

    International Nuclear Information System (INIS)

    Jones, Brent Manley; Jennings, Christopher A.; Coverdale, Christine Anne; Cuneo, Michael Edward; Maron, Yitzhak; LePell, Paul David; Deeney, Christopher

    2010-01-01

    Analysis of 50 mm diameter wire arrays at the Z Accelerator has shown experimentally the accretion of mass in a stagnating z pinch and provided insight into details of the radiating plasma species and plasma conditions. This analysis focused on nested wire arrays with a 2:1 (outeninner) mass, radius, and wire number ratio where Al wires were fielded on the outer array and Ni-clad Ti wires were fielded on the inner array.In this presentation, we will present analysis of data from other mixed Al/Ni-clad Ti configurations to further evaluate nested wire array dynamics and mass accretion. These additional configurations include the opposite configuration to that described above (Ni-clad Ti wires on the outer array, with Al wires on the inner array) as well as higher wire number Al configurations fielded to vary the interaction of the two arrays. These same variations were also assessed for a smaller diameter nested array configuration (40 mm). Variations in the emitted radiation and plasma conditions will be presented, along with a discussion of what the results indicate about the nested array dynamics. Additional evidence for mass accretion will also be presented.

  9. Effect of transcutaneous electrical muscle stimulation on postoperative muscle mass and protein synthesis

    DEFF Research Database (Denmark)

    Vinge, O; Edvardsen, L; Jensen, F

    1996-01-01

    In an experimental study, 13 patients undergoing major elective abdominal surgery were given postoperative transcutaneous electrical muscle stimulation (TEMS) to the quadriceps femoris muscle on one leg; the opposite leg served as control. Changes in cross-sectional area (CSA) and muscle protein ...... protein synthesis and muscle mass after abdominal surgery and should be evaluated in other catabolic states with muscle wasting.......In an experimental study, 13 patients undergoing major elective abdominal surgery were given postoperative transcutaneous electrical muscle stimulation (TEMS) to the quadriceps femoris muscle on one leg; the opposite leg served as control. Changes in cross-sectional area (CSA) and muscle protein...... synthesis were assessed by computed tomography and ribosome analysis of percutaneous muscle biopsies before surgery and on the sixth postoperative day. The percentage of polyribosomes in the ribosome suspension decreased significantly (P

  10. Novel biomarkers of changes in muscle mass or muscle pathology

    DEFF Research Database (Denmark)

    Arvanitidis, Athanasios

    healthy individuals and patients with different myopathy diseases, describe the underlying mechanisms of muscle conditions and possibly putative response to an intervention. There were three different studies where biomarkers were applied in this thesis. Study I involved 51 myositis patients (28...

  11. Counteracting age-related loss of skeletal muscle mass

    DEFF Research Database (Denmark)

    Bechshøft, Rasmus; Reitelseder, Søren; Højfeldt, Grith

    2016-01-01

    Background Aging is associated with decreased muscle mass and functional capacity, which in turn decrease quality of life. The number of citizens over the age of 65 years in the Western world will increase by 50 % over the next four decades, and this demographic shift brings forth new challenges...... at both societal and individual levels. Only a few longitudinal studies have been reported, but whey protein supplementation seems to improve muscle mass and function, and its combination with heavy strength training appears even more effective. However, heavy resistance training may reduce adherence...... Intervention Study will generate scientific evidence and recommendations to counteract age-related loss of skeletal muscle mass in elderly individuals....

  12. Inflammatory markers and loss of muscle mass (sarcopenia) and strength

    NARCIS (Netherlands)

    Schaap, Laura A; Pluijm, Saskia M F; Deeg, Dorly J H; Visser, Marjolein

    PURPOSE: The objective of this study was to investigate whether high levels of serum interleukin (IL)-6, C-reactive protein (CRP), and alpha1-antichymotrypsin (ACT) were associated with the loss of muscle strength or muscle mass (sarcopenia) in older persons. SUBJECTS: The study included 986 men and

  13. The accretion of solar material onto white dwarfs: No mixing with core material implies that the mass of the white dwarf is increasing

    Directory of Open Access Journals (Sweden)

    Sumner Starrfield

    2014-02-01

    Full Text Available Cataclysmic Variables (CVs are close binary star systems with one component a white dwarf (WD and the other a larger cooler star that fills its Roche Lobe. The cooler star is losing mass through the inner Lagrangian point of the binary and some unknown fraction of this material is accreted by the WD. One consequence of the WDs accreting material, is the possibility that they are growing in mass and will eventually reach the Chandrasekhar Limit. This evolution could result in a Supernova Ia (SN Ia explosion and is designated the Single Degenerate Progenitor (SD scenario. This paper is concerned with the SD scenario for SN Ia progenitors. One problem with the single degenerate scenario is that it is generally assumed that the accreting material mixes with WD core material at some time during the accretion phase of evolution and, since the typical WD has a carbon-oxygen CO core, the mixing results in large amounts of carbon and oxygen being brought up into the accreted layers. The presence of enriched carbon causes enhanced nuclear fusion and a Classical Nova explosion. Both observations and theoretical studies of these explosions imply that more mass is ejected than is accreted. Thus, the WD in a Classical Nova system is losing mass and cannot be a SN Ia progenitor. However, the composition in the nuclear burning region is important and, in new calculations reported here, the consequences to the WD of no mixing of accreted material with core material have been investigated so that the material involved in the explosion has only a Solar composition. WDs with a large range in initial masses and mass accretion rates have been evolved. I find that once sufficient material has been accreted, nuclear burning occurs in all evolutionary sequences and continues until a thermonuclear runaway (TNR occurs and the WD either ejects a small amount of material or its radius grows to about 1012 cm and the evolution is ended. In all cases where mass ejection occurs

  14. Discovery of the Accretion-Powered Millisecond Pulsar SWIFT 51756.9-2508 with a Low-Mass Companion

    Science.gov (United States)

    Krimm, H.A.; Markwardt, C.B.; Deloye, C.J.; Romano, P.; Chakrabarty, S.; Campana. S.; Cummings, J.C.; Galloway, D.K.; Gehrels, N.; Hartman, J.M.; hide

    2007-01-01

    We report on the discovery by the Swift Gamma-Ray Burst Explorer of the eighth known transient accretion-powered millisecond pulsar: SWIFT J1756.9-2508, as part of routine observations with the Swift Burst Alert Telescope hard X-ray transient monitor. The pulsar was subsequently observed by both the X-Ray Telescope on Swift and the Rossi X-Ray Timing Explorer Proportional Counter Array. It has a spin frequency of 182 Hz (5.5 ms) and an orbital period of 54.7 minutes. The minimum companion mass is between 0.0067 and 0.0086 Solar Mass, depending on the mass of the neutron star, and the upper limit on the mass is 0.030 Solar Mass (95% confidence level). Such a low mass is inconsistent with brown dwarf models. and comparison with white dwarf models suggests that the companion is a He-dominated donor whose thermal cooling has been at least modestly slowed by irradiation from the accretion flux. No X-ray bursts. dips, eclipses or quasi-periodic oscillations were detected. The current outburst lasted approx. 13 days and no earlier outbursts were found in archival data.

  15. Association between muscle mass and a single measurement of ...

    African Journals Online (AJOL)

    cause mortality significantly. It is strongly associated with the risk of heart attack, coronary artery disease, cardiovascular disease, stroke and liver disease. The relationship between muscle mass and a diagnosis of hypertension in a sample of ...

  16. A RECENT ACCRETION BURST IN THE LOW-MASS PROTOSTAR IRAS 15398-3359: ALMA IMAGING OF ITS RELATED CHEMISTRY

    International Nuclear Information System (INIS)

    Jørgensen, Jes K.; Brinch, Christian; Lindberg, Johan E.; Bisschop, Suzanne E.; Visser, Ruud; Bergin, Edwin A.; Sakai, Nami; Yamamoto, Satoshi; Harsono, Daniel; Van Dishoeck, Ewine F.; Persson, Magnus V.

    2013-01-01

    Low-mass protostars have been suggested to show highly variable accretion rates throughout their evolution. Such changes in accretion, and related heating of their ambient envelopes, may trigger significant chemical variations on different spatial scales and from source-to-source. We present images of emission from C 17 O, H 13 CO + , CH 3 OH, C 34 S and C 2 H toward the low-mass protostar IRAS 15398-3359 on 0.''5 (75 AU diameter) scales with the Atacama Large Millimeter/submillimeter Array at 340 GHz. The resolved images show that the emission from H 13 CO + is only present in a ring-like structure with a radius of about 1-1.''5 (150-200 AU) whereas the CO and other high dipole moment molecules are centrally condensed toward the location of the central protostar. We propose that HCO + is destroyed by water vapor present on small scales. The origin of this water vapor is likely an accretion burst during the last 100-1000 yr increasing the luminosity of IRAS 15398-3359 by a factor of 100 above its current luminosity. Such a burst in luminosity can also explain the centrally condensed CH 3 OH and extended warm carbon-chain chemistry observed in this source and furthermore be reflected in the relative faintness of its compact continuum emission compared to other protostars

  17. Regulation of skeletal muscle oxidative capacity and muscle mass by SIRT3.

    Directory of Open Access Journals (Sweden)

    Ligen Lin

    Full Text Available We have previously reported that the expression of mitochondrial deacetylase SIRT3 is high in the slow oxidative muscle and that the expression of muscle SIRT3 level is increased by dietary restriction or exercise training. To explore the function of SIRT3 in skeletal muscle, we report here the establishment of a transgenic mouse model with muscle-specific expression of the murine SIRT3 short isoform (SIRT3M3. Calorimetry study revealed that the transgenic mice had increased energy expenditure and lower respiratory exchange rate (RER, indicating a shift towards lipid oxidation for fuel usage, compared to control mice. The transgenic mice exhibited better exercise performance on treadmills, running 45% further than control animals. Moreover, the transgenic mice displayed higher proportion of slow oxidative muscle fibers, with increased muscle AMPK activation and PPARδ expression, both of which are known regulators promoting type I muscle fiber specification. Surprisingly, transgenic expression of SIRT3M3 reduced muscle mass up to 30%, likely through an up-regulation of FOXO1 transcription factor and its downstream atrophy gene MuRF-1. In summary, these results suggest that SIRT3 regulates the formation of oxidative muscle fiber, improves muscle metabolic function, and reduces muscle mass, changes that mimic the effects of caloric restriction.

  18. Partial Accretion in the Propeller Stage of Low-mass X-Ray Binary Aql X–1

    International Nuclear Information System (INIS)

    Güngör, C.; Ekşi, K. Y.; Göğüş, E.; Güver, T.

    2017-01-01

    Aql X–1 is one of the most prolific low-mass X-ray binary transients (LMXBTs) showing outbursts almost annually. We present the results of our spectral analyses of Rossi X-Ray Timing Explorer /proportional counter-array observations of the 2000 and 2011 outbursts. We investigate the spectral changes related to the changing disk-magnetosphere interaction modes of Aql X–1. The X-ray light curves of the outbursts of LMXBTs typically show phases of fast rise and exponential decay. The decay phase shows a “knee” where the flux goes from the slow-decay to the rapid-decay stage. We assume that the rapid decay corresponds to a weak propeller stage at which a fraction of the inflowing matter in the disk accretes onto the star. We introduce a novel method for inferring, from the light curve, the fraction of the inflowing matter in the disk that accretes onto the neutron star depending on the fastness parameter. We determine the fastness parameter range within which the transition from the accretion to the partial propeller stage is realized. This fastness parameter range is a measure of the scale height of the disk in units of the inner disk radius. We applied the method to a sample of outbursts of Aql X–1 with different maximum flux and duration times. We show that different outbursts with different maximum luminosity and duration follow a similar path in the parameter space of accreted/inflowing mass flux fraction versus fastness parameter.

  19. Partial Accretion in the Propeller Stage of Low-mass X-Ray Binary Aql X–1

    Energy Technology Data Exchange (ETDEWEB)

    Güngör, C.; Ekşi, K. Y. [İstanbul Technical University, Faculty of Science and Letters, Physics Engineering Department, 34469, İstanbul (Turkey); Göğüş, E. [Sabancı University, Faculty of Engineering and Natural Science, Orhanlı—Tuzla, 34956, İstanbul (Turkey); Güver, T., E-mail: gungorcan@itu.edu.tr [İstanbul University, Science Faculty, Department of Astronomy and Space Sciences, Beyazıt, 34119, İstanbul (Turkey)

    2017-10-10

    Aql X–1 is one of the most prolific low-mass X-ray binary transients (LMXBTs) showing outbursts almost annually. We present the results of our spectral analyses of Rossi X-Ray Timing Explorer /proportional counter-array observations of the 2000 and 2011 outbursts. We investigate the spectral changes related to the changing disk-magnetosphere interaction modes of Aql X–1. The X-ray light curves of the outbursts of LMXBTs typically show phases of fast rise and exponential decay. The decay phase shows a “knee” where the flux goes from the slow-decay to the rapid-decay stage. We assume that the rapid decay corresponds to a weak propeller stage at which a fraction of the inflowing matter in the disk accretes onto the star. We introduce a novel method for inferring, from the light curve, the fraction of the inflowing matter in the disk that accretes onto the neutron star depending on the fastness parameter. We determine the fastness parameter range within which the transition from the accretion to the partial propeller stage is realized. This fastness parameter range is a measure of the scale height of the disk in units of the inner disk radius. We applied the method to a sample of outbursts of Aql X–1 with different maximum flux and duration times. We show that different outbursts with different maximum luminosity and duration follow a similar path in the parameter space of accreted/inflowing mass flux fraction versus fastness parameter.

  20. TAK1 regulates skeletal muscle mass and mitochondrial function

    Science.gov (United States)

    Hindi, Sajedah M.; Sato, Shuichi; Xiong, Guangyan; Bohnert, Kyle R.; Gibb, Andrew A.; Gallot, Yann S.; McMillan, Joseph D.; Hill, Bradford G.

    2018-01-01

    Skeletal muscle mass is regulated by a complex array of signaling pathways. TGF-β–activated kinase 1 (TAK1) is an important signaling protein, which regulates context-dependent activation of multiple intracellular pathways. However, the role of TAK1 in the regulation of skeletal muscle mass remains unknown. Here, we report that inducible inactivation of TAK1 causes severe muscle wasting, leading to kyphosis, in both young and adult mice.. Inactivation of TAK1 inhibits protein synthesis and induces proteolysis, potentially through upregulating the activity of the ubiquitin-proteasome system and autophagy. Phosphorylation and enzymatic activity of AMPK are increased, whereas levels of phosphorylated mTOR and p38 MAPK are diminished upon inducible inactivation of TAK1 in skeletal muscle. In addition, targeted inactivation of TAK1 leads to the accumulation of dysfunctional mitochondria and oxidative stress in skeletal muscle of adult mice. Inhibition of TAK1 does not attenuate denervation-induced muscle wasting in adult mice. Finally, TAK1 activity is highly upregulated during overload-induced skeletal muscle growth, and inactivation of TAK1 prevents myofiber hypertrophy in response to functional overload. Overall, our study demonstrates that TAK1 is a key regulator of skeletal muscle mass and oxidative metabolism. PMID:29415881

  1. The low-mass stellar population in the young cluster Tr 37. Disk evolution, accretion, and environment

    Science.gov (United States)

    Sicilia-Aguilar, Aurora; Kim, Jinyoung Serena; Sobolev, Andrej; Getman, Konstantin; Henning, Thomas; Fang, Min

    2013-11-01

    Aims: We present a study of accretion and protoplanetary disks around M-type stars in the 4 Myr-old cluster Tr 37. With a well-studied solar-type population, Tr 37 is a benchmark for disk evolution. Methods: We used low-resolution spectroscopy to identify and classify 141 members (78 new ones) and 64 probable members, mostly M-type stars. Hα emission provides information about accretion. Optical, 2MASS, Spitzer, and WISE data are used to trace the spectral energy distributions (SEDs) and search for disks. We construct radiative transfer models to explore the structures of full-disks, pre-transition, transition, and dust-depleted disks. Results: Including the new members and the known solar-type stars, we confirm that a substantial fraction (~2/5) of disks show signs of evolution, either as radial dust evolution (transition/pre-transition disks) or as a more global evolution (with low small-dust masses, dust settling, and weak/absent accretion signatures). Accretion is strongly dependent on the SED type. About half of the transition objects are consistent with no accretion, and dust-depleted disks have weak (or undetectable) accretion signatures, especially among M-type stars. Conclusions: The analysis of accretion and disk structure suggests a parallel evolution of dust and gas. We find several distinct classes of evolved disks, based on SED type and accretion status, pointing to different disk dispersal mechanisms and probably different evolutionary paths. Dust depletion and opening of inner holes appear to be independent processes: most transition disks are not dust-depleted, and most dust-depleted disks do not require inner holes. The differences in disk structure between M-type and solar-type stars in Tr 37 (4 Myr old) are not as remarkable as in the young, sparse, Coronet cluster (1-2 Myr old), suggesting that other factors, like the environment/interactions in each cluster, are likely to play an important role in the disk evolution and dispersal. Finally, we

  2. Relation between body mass index percentile and muscle strength ...

    African Journals Online (AJOL)

    Relation between body mass index percentile and muscle strength and endurance. ... Egyptian Journal of Medical Human Genetics ... They were divided into three groups according to their body mass index percentile where group (a) is equal to or more than 5% percentile yet less than 85% percentile, group (b) is equal to ...

  3. The Splashback Radius of Halos from Particle Dynamics. II. Dependence on Mass, Accretion Rate, Redshift, and Cosmology

    Science.gov (United States)

    Diemer, Benedikt; Mansfield, Philip; Kravtsov, Andrey V.; More, Surhud

    2017-07-01

    The splashback radius R sp, the apocentric radius of particles on their first orbit after falling into a dark matter halo, has recently been suggested to be a physically motivated halo boundary that separates accreting from orbiting material. Using the Sparta code presented in Paper I, we analyze the orbits of billions of particles in cosmological simulations of structure formation and measure R sp for a large sample of halos that span a mass range from dwarf galaxy to massive cluster halos, reach redshift 8, and include WMAP, Planck, and self-similar cosmologies. We analyze the dependence of R sp/R 200m and M sp/M 200m on the mass accretion rate Γ, halo mass, redshift, and cosmology. The scatter in these relations varies between 0.02 and 0.1 dex. While we confirm the known trend that R sp/R 200m decreases with Γ, the relationships turn out to be more complex than previously thought, demonstrating that R sp is an independent definition of the halo boundary that cannot trivially be reconstructed from spherical overdensity definitions. We present fitting functions for R sp/R 200m and M sp/M 200m as a function of accretion rate, peak height, and redshift, achieving an accuracy of 5% or better everywhere in the parameter space explored. We discuss the physical meaning of the distribution of particle apocenters and show that the previously proposed definition of R sp as the radius of the steepest logarithmic density slope encloses roughly three-quarters of the apocenters. Finally, we conclude that no analytical model presented thus far can fully explain our results.

  4. Expression of porcine myostatin prodomain genomic sequence leads to a decrease in muscle growth, but significant intramuscular fat accretion in transgenic pigs.

    Science.gov (United States)

    Myostatin, a member of TGF-beta superfamily, is a dominant inhibitor of skeletal muscle development and growth. Previously, skeletal muscle-specific over-expression of myostatin prodomain cDNA (5’-region 886 nucleotide) dramatically increased growth performance and muscle mass in transgenic mice. I...

  5. THE H I MASS DENSITY IN GALACTIC HALOS, WINDS, AND COLD ACCRETION AS TRACED BY Mg II ABSORPTION

    Energy Technology Data Exchange (ETDEWEB)

    Kacprzak, Glenn G. [Swinburne University of Technology, Victoria 3122 (Australia); Churchill, Christopher W., E-mail: gkacprzak@astro.swin.edu.au, E-mail: cwc@nmsu.edu [New Mexico State University, Las Cruces, NM 88003 (United States)

    2011-12-20

    It is well established that Mg II absorption lines detected in background quasar spectra arise from gas structures associated with foreground galaxies. The degree to which galaxy evolution is driven by the gas cycling through halos is highly uncertain because their gas mass density is poorly constrained. Fitting the Mg II equivalent width (W) distribution with a Schechter function and applying the N(H I)-W correlation of Menard and Chelouche, we computed {Omega}(H I){sub MgII} {identical_to} {Omega}(H I){sub halo} = 1.41{sup +0.75}{sub -0.44} Multiplication-Sign 10{sup -4} for 0.4 {<=} z {<=} 1.4. We exclude damped Ly{alpha}'s (DLAs) from our calculations so that {Omega}(H I){sub halo} comprises accreting and/or outflowing halo gas not locked up in cold neutral clouds. We deduce that the cosmic H I gas mass density fraction in galactic halos traced by Mg II absorption is {Omega}(H I){sub halo}/{Omega}(H I){sub DLA} {approx_equal} 15% and {Omega}(H I){sub halo}/{Omega}{sub b} {approx_equal} 0.3%. Citing several lines of evidence, we propose that infall/accretion material is sampled by small W whereas outflow/winds are sampled by large W, and find that {Omega}(H I){sub infall} is consistent with {Omega}(H I){sub outflow} for bifurcation at W = 1.23{sup +0.15}{sub -0.28} Angstrom-Sign ; cold accretion would then comprise no more than {approx}7% of the total H I mass density. We discuss evidence that (1) the total H I mass cycling through halos remains fairly constant with cosmic time and that the accretion of H I gas sustains galaxy winds, and (2) evolution in the cosmic star formation rate depends primarily on the rate at which cool H I gas cycles through halos.

  6. Correlation between Body Mass Index, Gender, and Skeletal Muscle Mass Cut off Point in Bandung

    OpenAIRE

    Richi Hendrik Wattimena; Vitriana; Irma Ruslina Defi

    2017-01-01

    Objective: To determine the average skeletal muscle mass (SMM) value in young adults as a reference population; to analyze the correlation of gender, and body mass index to the cut off point; and to determine skeletal muscle mass cut off points of population in Bandung, Indonesia. Methods: This was a cross-sectional study involving 199 participants, 122 females and 77 males. The sampling technique used was the multistage random sampling. The participants were those who lived in four ma...

  7. [Variation of muscle mass and weight in critical patient].

    Science.gov (United States)

    Valls-Matarín, J; del Cotillo-Fuente, M; Grané-Mascarell, N; Quintana, S

    2015-01-01

    Quantify the muscle mass and body weight variation in critically ill patients and to identify associated factors. A descriptive follow-up study. Data for demographic variables, body weight, fluid balance, daily kilocalories, the amount of sedation and muscle relaxants received and motor physiotherapy applied were collected. Three consecutive measurements were performed in the brachial biceps and quadriceps rectus by using ultrasound, upon admission and every 5 days until discharge. 68 patients were included. Average age was of 73.5 [57-78,5] years. The median length of stay was 9.5 [5.5 -15] days. The median 16 (SD=5.7) daily kilocalories per kg/weight, 91.2% received sedation, 44.1% received muscle relaxants and 20% received physiotherapy. The patients presented a muscle wasting of 4.9 (SD=3.9)mm, p <.001 in the brachial biceps and 5.6 (SD=4.8)mm, p <.001 in the quadriceps rectus. Regression analysis selected the length of stay and the muscle relaxants are the most influential variables in the brachial biceps muscle wasting (R2=0.4), and length of stay as the most influential in the quadriceps rectus muscle wasting (R2=0.3). Patient's mean body weight on admission was of 81.1 (SD=15)kg and 81.2 (SD=14.2)kg on discharge, p=.95. The critically ill patient presents a significant muscle waste related with the length of stay and the treatment received with muscle relaxants. Patients are being discharged with a similar body weight to which they were admitted but with a significant reduction of muscle mass. Copyright © 2014 Elsevier España, S.L.U. y SEEIUC. All rights reserved.

  8. The Emerging Paradigm of Pebble Accretion

    NARCIS (Netherlands)

    Ormel, C.W.; Pessah, M.; Gressel, O.

    2017-01-01

    Pebble accretion is the mechanism in which small particles ("pebbles") accrete onto big bodies big (planetesimals or planetary embryos) in gas-rich environments. In pebble accretion accretion , accretion occurs by settling and depends only on the mass of the gravitating body gravitating , not its

  9. THE SELF-SIMILARITY OF THE CIRCUMGALACTIC MEDIUM WITH GALAXY VIRIAL MASS: IMPLICATIONS FOR COLD-MODE ACCRETION

    Energy Technology Data Exchange (ETDEWEB)

    Churchill, Christopher W.; Nielsen, Nikole M.; Trujillo-Gomez, Sebastian [Department of Astronomy, New Mexico State University, Las Cruces, NM 88003 (United States); Kacprzak, Glenn G. [Center for Astrophysics and Supercomputing, Swinburne University of Technology, Victoria 3122 (Australia)

    2013-02-01

    We apply halo abundance matching to obtain galaxy virial masses, M{sub h}, and radii, R{sub vir}, for 183 'isolated' galaxies from the 'Mg II Absorber-Galaxy Catalog'. All galaxies have spectroscopic redshifts (0.07 {<=} z {<=} 1.12) and their circumgalactic medium (CGM) is probed in Mg II absorption within projected galactocentric distances D {<=} 200 kpc. We examine the behavior of equivalent width, W{sub r} (2796), and covering fraction, f{sub c} , as a function of D, D/R{sub vir}, and M{sub h}. Bifurcating the sample at the median mass log M{sub h}/M{sub Sun} = 12, we find (1) systematic segregation of M{sub h} on the W{sub r} (2796)-D plane (4.0{sigma}); high-mass halos are found at higher D with larger W{sub r} (2796) compared to low-mass halos. On the W{sub r} (2796)-D/R{sub vir} plane, mass segregation vanishes and we find W{sub r} (2796){proportional_to}(D/R{sub vir}){sup -2} (8.9{sigma}). (2) High-mass halos have larger f{sub c} at a given D, whereas f{sub c} is independent of M{sub h} at all D/R{sub vir}. (3) f{sub c} is constant with M{sub h} over the range 10.7 {<=} log M{sub h}/M{sub Sun} {<=} 13.9 within a given D or D/R{sub vir}. The combined results suggest the Mg II absorbing CGM is self-similar with halo mass, even above log M{sub h}/M{sub Sun} {approx_equal} 12, where cold mode accretion is predicted to be quenched. If theory is correct, either outflows or sub-halos must contribute to absorption in high-mass halos such that low- and high-mass halos are observationally indistinguishable using Mg II absorption strength once impact parameter is scaled by halo mass. Alternatively, the data may indicate predictions of a universal shut down of cold-mode accretion in high-mass halos may require revision.

  10. Myoglobin plasma level related to muscle mass and fiber composition: a clinical marker of muscle wasting?

    Science.gov (United States)

    Weber, Marc-André; Kinscherf, Ralf; Krakowski-Roosen, Holger; Aulmann, Michael; Renk, Hanna; Künkele, Annette; Edler, Lutz; Kauczor, Hans-Ulrich; Hildebrandt, Wulf

    2007-08-01

    Progressive muscle wasting is a central feature of cancer-related cachexia and has been recognized as a determinant of poor prognosis and quality of life. However, until now, no easily assessable clinical marker exists that allows to predict or to track muscle wasting. The present study evaluated the potential of myoglobin (MG) plasma levels to indicate wasting of large locomotor muscles and, moreover, to reflect the loss of MG-rich fiber types, which are most relevant for daily performance. In 17 cancer-cachectic patients (weight loss 22%) and 27 age- and gender-matched healthy controls, we determined plasma levels of MG and creatine kinase (CK), maximal quadriceps muscle cross-sectional area (CSA) by magnetic resonance imaging, muscle morphology and fiber composition in biopsies from the vastus lateralis muscle, body cell mass (BCM) by impedance technique as well as maximal oxygen uptake (VO(2)max). In cachectic patients, plasma MG, muscle CSA, BCM, and VO(2)max were 30-35% below control levels. MG showed a significant positive correlation to total muscle CSA (r = 0.65, p max as an important functional readout. CK plasma levels appear to be less reliable because prolonged increases are observed in even subclinical myopathies or after exercise. Notably, cancer-related muscle wasting was not associated with increases in plasma MG or CK in this study.

  11. EPISODIC ACCRETION AT EARLY STAGES OF EVOLUTION OF LOW-MASS STARS AND BROWN DWARFS: A SOLUTION FOR THE OBSERVED LUMINOSITY SPREAD IN H-R DIAGRAMS?

    International Nuclear Information System (INIS)

    Baraffe, I.; Chabrier, G.; Gallardo, J.

    2009-01-01

    We present evolutionary models for young low-mass stars and brown dwarfs taking into account episodic phases of accretion at early stages of the evolution, a scenario supported by recent large surveys of embedded protostars. An evolution including short episodes of vigorous accretion followed by longer quiescent phases can explain the observed luminosity spread in H-R diagrams of star-forming regions at ages of a few Myr, for objects ranging from a few Jupiter masses to a few tenths of a solar mass. The gravitational contraction of these accreting objects strongly departs from the standard Hayashi track at constant T eff . The best agreement with the observed luminosity scatter is obtained if most of the accretion shock energy is radiated away. The obtained luminosity spread at 1 Myr in the H-R diagram is equivalent to what can be misinterpreted as an ∼10 Myr age spread for non-accreting objects. We also predict a significant spread in radius at a given T eff , as suggested by recent observations. These calculations bear important consequences for our understanding of star formation and early stages of evolution and on the determination of the initial mass function for young (≤ a few Myr) clusters. Our results also show that the concept of a stellar birthline for low-mass objects has no valid support.

  12. Muscle hypertrophy: a narrative review on training principles for increasing muscle mass

    OpenAIRE

    Howe, Louis; Read, Paul; Waldron, Mark

    2017-01-01

    Developing muscle cross-sectional area has the potential to enhance performance for many athletes. Because emerging evidence challenges traditional beliefs regarding the prescription of hypertrophy-focused training programs, this review provides an overview of the current literature relating, specifically, to programming variables. Evidence-based recommendations are provided for the design of effective resistance-training programs, with the goal of increasing an athlete's skeletal muscle mass.

  13. Blinded by the light: on the relationship between CO first overtone emission and mass accretion rate in massive young stellar objects

    Science.gov (United States)

    Ilee, J. D.; Oudmaijer, R. D.; Wheelwright, H. E.; Pomohaci, R.

    2018-04-01

    To date, there is no explanation as to why disc-tracing CO first overtone (or `bandhead') emission is not a ubiquitous feature in low- to medium-resolution spectra of massive young stellar objects, but instead is only detected toward approximately 25 per cent of their spectra. In this paper, we investigate the hypothesis that only certain mass accretion rates result in detectable bandhead emission in the near infrared spectra of MYSOs. Using an analytic disc model combined with an LTE model of the CO emission, we find that high accretion rates (≳ 10-4 M⊙yr-1) result in large dust sublimation radii, a larger contribution to the K-band continuum from hot dust at the dust sublimation radius, and therefore correspondingly lower CO emission with respect to the continuum. On the other hand, low accretion rates (≲ 10-6 M⊙yr-1) result in smaller dust sublimation radii, a correspondingly smaller emitting area of CO, and thus also lower CO emission with respect to the continuum. In general, moderate accretion rates produce the most prominent, and therefore detectable, CO first overtone emission. We compare our findings to a recent near-infrared spectroscopic survey of MYSOs, finding results consistent with our hypothesis. We conclude that the detection rate of CO bandhead emission in the spectra of MYSOs could be the result of MYSOs exhibiting a range of mass accretion rates, perhaps due to the variable accretion suggested by recent multi-epoch observations of these objects.

  14. Mass loss from pre-main-sequence accretion disks. I - The accelerating wind of FU Orionis

    Science.gov (United States)

    Calvet, Nuria; Hartmann, Lee; Kenyon, Scott J.

    1993-01-01

    We present evidence that the wind of the pre-main-sequence object FU Orionis arises from the surface of the luminous accretion disk. A disk wind model calculated assuming radiative equilibrium explains the differential behavior of the observed asymmetric absorption-line profiles. The model predicts that strong lines should be asymmetric and blueshifted, while weak lines should be symmetric and double-peaked due to disk rotation, in agreement with observations. We propose that many blueshifted 'shell' absorption features are not produced in a true shell of material, but rather form in a differentially expanding wind that is rapidly rotating. The inference of rapid rotation supports the proposal that pre-main-sequence disk winds are rotationally driven.

  15. Accretion from an inhomogeneous medium

    International Nuclear Information System (INIS)

    Livio, M.; Soker, N.; Koo, M. de; Savonije, G.J.

    1986-01-01

    The problem of accretion by a compact object from an inhomogeneous medium is studied in the general γnot=1 case. The mass accretion rate is found to decrease with increasing γ. The rate of accretion of angular momentum is found to be significantly lower than the rate at which angular momentum is deposited into the Bondi-Hoyle, symmetrical, accretion cylinder. The consequences of the results are studied for the cases of neutron stars accreting from the winds of early-type companions and white dwarfs and main-sequence stars accreting from winds of cool giants. (author)

  16. Linking black hole growth with host galaxies: the accretion-stellar mass relation and its cosmic evolution

    Science.gov (United States)

    Yang, G.; Brandt, W. N.; Vito, F.; Chen, C.-T. J.; Trump, J. R.; Luo, B.; Sun, M. Y.; Xue, Y. Q.; Koekemoer, A. M.; Schneider, D. P.; Vignali, C.; Wang, J.-X.

    2018-04-01

    Previous studies suggest that the growth of supermassive black holes (SMBHs) may be fundamentally related to host-galaxy stellar mass (M⋆). To investigate this SMBH growth-M⋆ relation in detail, we calculate long-term SMBH accretion rate as a function of M⋆ and redshift [\\overlineBHAR(M_{\\star }, z)] over ranges of log (M⋆/M⊙) = 9.5-12 and z = 0.4-4. Our \\overlineBHAR(M_{\\star }, z) is constrained by high-quality survey data (GOODS-South, GOODS-North and COSMOS), and by the stellar mass function and the X-ray luminosity function. At a given M⋆, \\overlineBHAR is higher at high redshift. This redshift dependence is stronger in more massive systems [for log (M⋆/M⊙) ≈ 11.5, \\overlineBHAR is three decades higher at z = 4 than at z = 0.5], possibly due to AGN feedback. Our results indicate that the ratio between \\overlineBHAR and average star formation rate (\\overlineSFR) rises towards high M⋆ at a given redshift. This \\overlineBHAR/\\overlineSFR dependence on M⋆ does not support the scenario that SMBH and galaxy growth are in lockstep. We calculate SMBH mass history [MBH(z)] based on our \\overlineBHAR(M_{\\star }, z) and the M⋆(z) from the literature, and find that the MBH-M⋆ relation has weak redshift evolution since z ≈ 2. The MBH/M⋆ ratio is higher towards massive galaxies: it rises from ≈1/5000 at log M⋆ ≲ 10.5 to ≈1/500 at log M⋆ ≳ 11.2. Our predicted MBH/M⋆ ratio at high M⋆ is similar to that observed in local giant ellipticals, suggesting that SMBH growth from mergers is unlikely to dominate over growth from accretion.

  17. SPECTRAL INDEX AS A FUNCTION OF MASS ACCRETION RATE IN BLACK HOLE SOURCES: MONTE CARLO SIMULATIONS AND AN ANALYTICAL DESCRIPTION

    International Nuclear Information System (INIS)

    Laurent, Philippe; Titarchuk, Lev

    2011-01-01

    We present herein a theoretical study of correlations between spectral indexes of X-ray emergent spectra and mass accretion rate ( m-dot ) in black hole (BH) sources, which provide a definitive signature for BHs. It has been firmly established, using the Rossi X-ray Timing Explorer (RXTE) in numerous BH observations during hard-soft state spectral evolution, that the photon index of X-ray spectra increases when m-dot increases and, moreover, the index saturates at high values of m-dot . In this paper, we present theoretical arguments that the observationally established index saturation effect versus mass accretion rate is a signature of the bulk (converging) flow onto the BH. Also, we demonstrate that the index saturation value depends on the plasma temperature of converging flow. We self-consistently calculate the Compton cloud (CC) plasma temperature as a function of mass accretion rate using the energy balance between energy dissipation and Compton cooling. We explain the observable phenomenon, index- m-dot correlations using a Monte Carlo simulation of radiative processes in the innermost part (CC) of a BH source and we account for the Comptonization processes in the presence of thermal and bulk motions, as basic types of plasma motion. We show that, when m-dot increases, BH sources evolve to high and very soft states (HSS and VSS, respectively), in which the strong blackbody(BB)-like and steep power-law components are formed in the resulting X-ray spectrum. The simultaneous detections of these two components strongly depends on sensitivity of high-energy instruments, given that the relative contribution of the hard power-law tail in the resulting VSS spectrum can be very low, which is why, to date RXTE observations of the VSS X-ray spectrum have been characterized by the presence of the strong BB-like component only. We also predict specific patterns for high-energy e-fold (cutoff) energy (E fold ) evolution with m-dot for thermal and dynamical (bulk

  18. The Regulation of Muscle Mass by Endogenous Glucocorticoids

    Directory of Open Access Journals (Sweden)

    Daniel L Marks

    2015-02-01

    Full Text Available Glucocorticoids are highly conserved fundamental regulators of energy homeostasis. In response to stress in the form of perceived danger or acute inflammation, glucocorticoids are released from the adrenal gland, rapidly mobilizing energy from carbohydrate, fat and protein stores. In the case of inflammation, mobilized protein is critical for the rapid synthesis of acute phase reactants and an efficient immune response to infection. While adaptive in response to infection, chronic mobilization can lead to a p rofound depletion of energy stores. Skeletal muscle represents the major body store of protein, and can become substantially atrophied under conditions of chronic inflammation. Glucocorticoids elicit the atrophy of muscle by increasing the rate of protein degradation by the ubiquitin-proteasome system and autophagy lysosome system. Protein synthesis is also suppressed at the level of translational initiation, preventing the production of new myofibrillar protein. Glucocorticoids also antagonize the action of anabolic regulators such as insulin further exacerbating the loss of protein and muscle mass. The loss of muscle mass in the context of chronic disease is a key feature of cachexia and contributes substantially to morbidity and mortality. A growing body of evidence demonstrates that glucocorticoid signaling is a common mediator of wasting, irrespective of the underlying initiator or disease state. This review will highlight fundamental mechanisms of glucocorticoid signaling and detail the mechanisms of glucocorticoid-induced muscle atrophy. Additionally, the evidence for glucocorticoids as a driver of muscle wasting in numerous disease states will be discussed. Given the burden of wasting diseases and the nodal nature of glucocorticoid signaling, effective anti-glucocorticoid therapy would be a valuable clinical tool. Therefore, the progress and potential pitfalls in the development of glucocorticoid antagonists for muscle wasting will

  19. On the Observability of Individual Population III Stars and Their Stellar-mass Black Hole Accretion Disks through Cluster Caustic Transits

    Science.gov (United States)

    Windhorst, Rogier A.; Timmes, F. X.; Wyithe, J. Stuart B.; Alpaslan, Mehmet; Andrews, Stephen K.; Coe, Daniel; Diego, Jose M.; Dijkstra, Mark; Driver, Simon P.; Kelly, Patrick L.; Kim, Duho

    2018-02-01

    We summarize panchromatic Extragalactic Background Light data to place upper limits on the integrated near-infrared surface brightness (SB) that may come from Population III stars and possible accretion disks around their stellar-mass black holes (BHs) in the epoch of First Light, broadly taken from z ≃ 7–17. Theoretical predictions and recent near-infrared power spectra provide tighter constraints on their sky signal. We outline the physical properties of zero-metallicity Population III stars from MESA stellar evolution models through helium depletion and of BH accretion disks at z≳ 7. We assume that second-generation non-zero-metallicity stars can form at higher multiplicity, so that BH accretion disks may be fed by Roche-lobe overflow from lower-mass companions. We use these near-infrared SB constraints to calculate the number of caustic transits behind lensing clusters that the James Webb Space Telescope and the next-generation ground-based telescopes may observe for both Population III stars and their BH accretion disks. Typical caustic magnifications can be μ ≃ {10}4{--}{10}5, with rise times of hours and decline times of ≲ 1 year for cluster transverse velocities of {v}T≲ 1000 km s‑1. Microlensing by intracluster-medium objects can modify transit magnifications but lengthen visibility times. Depending on BH masses, accretion-disk radii, and feeding efficiencies, stellar-mass BH accretion-disk caustic transits could outnumber those from Population III stars. To observe Population III caustic transits directly may require monitoring 3–30 lensing clusters to {AB}≲ 29 mag over a decade.

  20. On Estimating the Mass of Keplerian Accretion Disks in H2O Maser Galaxies

    Science.gov (United States)

    Kuo, C. Y.; Reid, M. J.; Braatz, J. A.; Gao, F.; Impellizzeri, C. M. V.; Chien, W. T.

    2018-06-01

    H2O maser disks with Keplerian rotation in active galactic nuclei offer a clean way to determine accurate black hole mass and the Hubble constant. An important assumption made in using a Keplerian H2O maser disk for measuring black hole mass and the Hubble constant is that the disk mass is negligible compared to the black hole mass. A simple and useful model of Huré et al. can be used to test this assumption. In that work, the authors apply a linear disk model to a position–dynamical mass diagram and re-analyze position–velocity data from H2O maser disks associated with active galactic nuclei. They claim that a maser disk with nearly perfect Keplerian rotation could have a disk mass comparable to the black hole mass. This would imply that ignoring the effects of disk self-gravity can lead to large systematic errors in the measurement of black hole mass and the Hubble constant. We examine their methods and find that their large estimated disk masses of Keplerian disks are likely the result of their use of projected instead of three-dimensional position and velocity information. To place better constraints on the disk masses of Keplerian maser systems, we incorporate disk self-gravity into a three-dimensional Bayesian modeling program for maser disks and also evaluate constraints based on the physical conditions for disks that support water maser emission. We find that there is little evidence that disk masses are dynamically important at the ≲1% level compared to the black holes.

  1. Diagnostic ultrasound estimates of muscle mass and muscle quality discriminate between women with and without sarcopenia

    Directory of Open Access Journals (Sweden)

    Catheeja eIsmail

    2015-10-01

    Full Text Available Introduction: Age-related changes in muscle mass and muscle tissue composition contribute to diminished strength in older adults. The objectives of this study are to examine if an assessment method using mobile diagnostic ultrasound augments well-known determinants of lean body mass (LBM to aid sarcopenia staging, and if a sonographic measure of muscle quality is associated with muscle performance.Methods: Twenty community-dwelling female subjects participated in the study (age = 43.4 ±20.9 years; BMI: 23.8, interquartile range: 8.5. Dual energy X-ray absorptiometry (DXA and diagnostic ultrasound morphometry were used to estimate LBM. Muscle tissue quality was estimated via the echogenicity using grayscale histogram analysis. Peak force was measured with grip dynamometry and scaled for body size. Bivariate and multiple regression analyses were used to determine the association of the predictor variables with appendicular lean mass (aLM/ht2, and examine the relationship between scaled peak force values and muscle echogenicity. The sarcopenia LBM cut point value of 6.75 kg/m2 determined participant assignment into the Normal LBM and Low LBM subgroups.Results: The selected LBM predictor variables were body mass index (BMI, ultrasound morphometry, and age. Although BMI exhibited a significant positive relationship with aLM/ht2 (adj. R2 = .61, p < .001, the strength of association improved with the addition of ultrasound morphometry and age as predictor variables (adj. R2 = .85, p < .001. Scaled peak force was associated with age and echogenicity (adj. R2 = .53, p < .001, but not LBM. The Low LBM subgroup of women (n = 10 had higher scaled peak force, lower BMI, and lower echogenicity values in comparison to the Normal LBM subgroup (n = 10; p < .05.Conclusions: Diagnostic ultrasound morphometry values are associated with LBM, and improve the BMI predictive model for aLM/ht2 in women. In addition, ultrasound proxy measures of muscle quality are more

  2. Accretion flow dynamics during 1999 outburst of XTE J1859+226—modeling of broadband spectra and constraining the source mass

    Science.gov (United States)

    Nandi, Anuj; Mandal, S.; Sreehari, H.; Radhika, D.; Das, Santabrata; Chattopadhyay, I.; Iyer, N.; Agrawal, V. K.; Aktar, R.

    2018-05-01

    We examine the dynamical behavior of accretion flow around XTE J1859+226 during the 1999 outburst by analyzing the entire outburst data (˜166 days) from RXTE Satellite. Towards this, we study the hysteresis behavior in the hardness intensity diagram (HID) based on the broadband (3-150 keV) spectral modeling, spectral signature of jet ejection and the evolution of Quasi-periodic Oscillation (QPO) frequencies using the two-component advective flow model around a black hole. We compute the flow parameters, namely Keplerian accretion rate (\\dot{m}d), sub-Keplerian accretion rate (\\dot{m}h), shock location (rs) and black hole mass (M_{bh}) from the spectral modeling and study their evolution along the q-diagram. Subsequently, the kinetic jet power is computed as L^{obs}_{jet} ˜3-6 ×10^{37} erg s^{-1} during one of the observed radio flares which indicates that jet power corresponds to 8-16% mass outflow rate from the disc. This estimate of mass outflow rate is in close agreement with the change in total accretion rate (˜14%) required for spectral modeling before and during the flare. Finally, we provide a mass estimate of the source XTE J1859+226 based on the spectral modeling that lies in the range of 5.2-7.9 M_{⊙} with 90% confidence.

  3. The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice

    International Nuclear Information System (INIS)

    Hamrick, Mark W.; Herberg, Samuel; Arounleut, Phonepasong; He, Hong-Zhi; Shiver, Austin; Qi, Rui-Qun; Zhou, Li; Isales, Carlos M.

    2010-01-01

    Research highlights: → Aging is associated with muscle atrophy and loss of muscle mass, known as the sarcopenia of aging. → We demonstrate that age-related muscle atrophy is associated with marked changes in miRNA expression in muscle. → Treating aged mice with the adipokine leptin significantly increased muscle mass and the expression of miRNAs involved in muscle repair. → Recombinant leptin therapy may therefore be a novel approach for treating age-related muscle atrophy. -- Abstract: Age-associated loss of muscle mass, or sarcopenia, contributes directly to frailty and an increased risk of falls and fractures among the elderly. Aged mice and elderly adults both show decreased muscle mass as well as relatively low levels of the fat-derived hormone leptin. Here we demonstrate that loss of muscle mass and myofiber size with aging in mice is associated with significant changes in the expression of specific miRNAs. Aging altered the expression of 57 miRNAs in mouse skeletal muscle, and many of these miRNAs are now reported to be associated specifically with age-related muscle atrophy. These include miR-221, previously identified in studies of myogenesis and muscle development as playing a role in the proliferation and terminal differentiation of myogenic precursors. We also treated aged mice with recombinant leptin, to determine whether leptin therapy could improve muscle mass and alter the miRNA expression profile of aging skeletal muscle. Leptin treatment significantly increased hindlimb muscle mass and extensor digitorum longus fiber size in aged mice. Furthermore, the expression of 37 miRNAs was altered in muscles of leptin-treated mice. In particular, leptin treatment increased the expression of miR-31 and miR-223, miRNAs known to be elevated during muscle regeneration and repair. These findings suggest that aging in skeletal muscle is associated with marked changes in the expression of specific miRNAs, and that nutrient-related hormones such as leptin

  4. The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice

    Energy Technology Data Exchange (ETDEWEB)

    Hamrick, Mark W., E-mail: mhamrick@mail.mcg.edu [Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Department of Orthopaedic Surgery, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Herberg, Samuel; Arounleut, Phonepasong [Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Department of Orthopaedic Surgery, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); He, Hong-Zhi [Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI (United States); Department of Dermatology, Henry Ford Health System, Detroit, MI (United States); Shiver, Austin [Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Department of Orthopaedic Surgery, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Qi, Rui-Qun [Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI (United States); Department of Dermatology, Henry Ford Health System, Detroit, MI (United States); Zhou, Li [Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI (United States); Department of Dermatology, Henry Ford Health System, Detroit, MI (United States); Department of Internal Medicine, Henry Ford Health System, Detroit, MI (United States); Isales, Carlos M. [Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Department of Orthopaedic Surgery, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); others, and

    2010-09-24

    Research highlights: {yields} Aging is associated with muscle atrophy and loss of muscle mass, known as the sarcopenia of aging. {yields} We demonstrate that age-related muscle atrophy is associated with marked changes in miRNA expression in muscle. {yields} Treating aged mice with the adipokine leptin significantly increased muscle mass and the expression of miRNAs involved in muscle repair. {yields} Recombinant leptin therapy may therefore be a novel approach for treating age-related muscle atrophy. -- Abstract: Age-associated loss of muscle mass, or sarcopenia, contributes directly to frailty and an increased risk of falls and fractures among the elderly. Aged mice and elderly adults both show decreased muscle mass as well as relatively low levels of the fat-derived hormone leptin. Here we demonstrate that loss of muscle mass and myofiber size with aging in mice is associated with significant changes in the expression of specific miRNAs. Aging altered the expression of 57 miRNAs in mouse skeletal muscle, and many of these miRNAs are now reported to be associated specifically with age-related muscle atrophy. These include miR-221, previously identified in studies of myogenesis and muscle development as playing a role in the proliferation and terminal differentiation of myogenic precursors. We also treated aged mice with recombinant leptin, to determine whether leptin therapy could improve muscle mass and alter the miRNA expression profile of aging skeletal muscle. Leptin treatment significantly increased hindlimb muscle mass and extensor digitorum longus fiber size in aged mice. Furthermore, the expression of 37 miRNAs was altered in muscles of leptin-treated mice. In particular, leptin treatment increased the expression of miR-31 and miR-223, miRNAs known to be elevated during muscle regeneration and repair. These findings suggest that aging in skeletal muscle is associated with marked changes in the expression of specific miRNAs, and that nutrient

  5. NEAR-INFRARED SPECTROSCOPY OF LOW-MASS X-RAY BINARIES: ACCRETION DISK CONTAMINATION AND COMPACT OBJECT MASS DETERMINATION IN V404 Cyg AND Cen X-4

    International Nuclear Information System (INIS)

    Khargharia, Juthika; Froning, Cynthia S.; Robinson, Edward L.

    2010-01-01

    We present near-infrared (NIR) broadband (0.80-2.42 μm) spectroscopy of two low-mass X-ray binaries: V404 Cyg and Cen X-4. One important parameter required in the determination of the mass of the compact objects in these systems is the binary inclination. We can determine the inclination by modeling the ellipsoidal modulations of the Roche-lobe filling donor star, but the contamination of the donor star light from other components of the binary, particularly the accretion disk, must be taken into account. To this end, we determined the donor star contribution to the infrared flux by comparing the spectra of V404 Cyg and Cen X-4 to those of various field K-stars of known spectral type. For V404 Cyg, we determined that the donor star has a spectral type of K3 III. We determined the fractional donor contribution to the NIR flux in the H and K bands as 0.98 ± 0.05 and 0.97 ± 0.09, respectively. We remodeled the H-band light curve from Sanwal et al. after correcting for the donor star contribution to obtain a new value for the binary inclination. From this, we determined the mass of the black hole in V404 Cyg to be M BH = 9.0 +0.2 -0.6 M sun . We performed the same spectral analysis for Cen X-4 and found the spectral type of the donor star to be in the range K5-M1 V. The donor star contribution in Cen X-4 is 0.94 ± 0.14 in the H band while in the K band, the accretion disk can contribute up to 10% of the infrared flux. We remodeled the H-band light curve from Shahbaz et al., again correcting for the fractional contribution of the donor star to obtain the inclination. From this, we determined the mass of the neutron star as M NS = 1.5 +0.1 -0.4 M sun . However, the masses obtained for both systems should be viewed with some caution since contemporaneous light curve and spectral data are required to obtain definitive masses.

  6. Appendicular Skeletal Muscle Mass Reference Values and the Peak Muscle Mass to Identify Sarcopenia among Iranian Healthy Population.

    Science.gov (United States)

    Shafiee, Gita; Ostovar, Afshin; Heshmat, Ramin; Keshtkar, Abbas Ali; Sharifi, Farshad; Shadman, Zhaleh; Nabipour, Iraj; Soltani, Akbar; Larijani, Bagher

    2018-01-01

    Sacopenia is a common problem in elderly with the adverse outcomes. The objective of this study was to estimate the peak appendicular skeletal muscle mass (ASM) and age of its attainment by sex among the Iranian population. A total of 691 men and women aged 18-94 years participated in this cross-sectional, population-based study in Bushehr, Iran. ASM was measured by dual X-ray absorptiometry. Cutoff points for men and women were established considering two standard deviations (SDs) below the mean values of the skeletal muscle index (SMI) for young reference groups. The relationship between ASM and age was described by the second-degree regression models. Two SDs below the mean SMIs of reference groups were as cutoff values of low muscle mass in Iranian population. The peak ASM values were 21.35 ± 0.12 Kg and 13.68 ± 0.10 Kg, and the age at peak ASM were 26 (24-28) years and 34 (33-35) years for men and women, respectively. Mean and SD of SMI in those ages were 7.01 ± 0.02 Kg/m 2 and 5.44 ± 0.02 Kg/m 2 among men and women, respectively. Calculated cutoff values of low muscle mass among the Iranian population were 7.0 Kg/m 2 and 5.4 Kg/m 2 among men and women, respectively. Iranian reference values of SMI for both genders were similar to Asia Working Group for Sarcopenia recommendation and lower than the United States and European values. Further studies from different nations and the Middle East countries are needed to obtain reference values for populations, enabling the researchers for comparison and also more valid reports on sarcopenia prevalence.

  7. Psoas muscle cross-sectional area as a measure of whole body lean muscle mass in maintenance hemodialysis patients

    Science.gov (United States)

    Morrell, Glen R.; Ikizler, Talat A.; Chen, Xiaorui; Heilbrun, Marta E.; Wei, Guo; Boucher, Robert; Beddhu, Srinivasan

    2016-01-01

    Objective We investigate whether psoas or paraspinous muscle area measured on a single L4–5 image is a useful measure of whole lean body mass compared to dedicated mid-thigh magnetic resonance imaging (MRI). Design Observational study. Setting Outpatient dialysis units and a research clinic. Subjects 105 adult participants on maintenance hemodialysis. No control group was used. Exposure variables Psoas muscle area, paraspinous muscle area, and mid-thigh muscle area (MTMA) were measured by MRI. Main outcome measure Lean body mass was measured by dual-energy absorptiometry (DEXA) scan. Results In separate multivariable linear regression models, psoas, paraspinous, and mid-thigh muscle area were associated with increase in lean body mass. In separate multivariate logistic regression models, c-statistics for diagnosis of sarcopenia (defined as lean body mass) were 0.69 for paraspinous muscle area, 0.81 for psoas muscle area, and 0.89 for mid-thigh muscle area. With sarcopenia defined as lean body mass, the corresponding c-statistics were 0.71, 0.92, and 0.94. Conclusions We conclude that psoas muscle area provides a good measure of whole body muscle mass, better than paraspinous muscle area but slightly inferior to mid thigh measurement. Hence, in body composition studies a single axial MR image at the L4–L5 level can be used to provide information on both fat and muscle and may eliminate the need for time-consuming measurement of muscle area in the thigh. PMID:26994780

  8. On the Observability of Individual Population III Stars and Their Stellar-mass Black Hole Accretion Disks through Cluster Caustic Transits

    Science.gov (United States)

    Windhorst, Rogier A.; Wyithe, Stuart; Alpaslan, Mehmet; Timmes, F. X.; Andrews, Stephen K.; Kim, Duho; Kelly, Patrick; Coe, Dan A.; Diego, Jose M.; Driver, Simon P.; Dijkstra, Mark

    2018-06-01

    We summarize panchromatic Extragalactic Background Light data to place upper limits on the integrated near-IR surface brightness (SB) that may come from Population III stars and possible accretion disks around their stellar-mass black holes (BHs) in the epoch of First Light, broadly taken from z=7-17.We outline the physical properties of zero-metallicity Population III stars from MESA stellar evolution models through helium depletion and of BH accretion disks at z>7. We assume that second-generation non-zero-metallicity stars can form at higher multiplicity, so that BH accretion disks may be fed by Roche-lobe overflow from lower-mass companions.We use these near-infrared SB constraints to calculate the number of caustic transits behind lensing clusters that the James Webb Space Telescope and the next-generation ground-based telescopes may observe for both Population III stars and their BH accretion disks. Typical caustic magnifications can be 10^4-10^5x, with rise times of hours and decline times of z~Economia y Competitividad of Spain Consolider Project CSD2010-00064.

  9. Mass loss, levitation, accretion, and the sharp-lined features in hot white dwarfs

    International Nuclear Information System (INIS)

    Bruhweiler, F.C.; Kondo, Y.

    1983-01-01

    We have studied eight white dwarfs, seven DA and one He-rich types, observed at a high resolution (lambda/Δlambdaroughly-equal10 4 ) with the International Ultraviolet Explorer (IUE). Of the seven DA white dwarfs, three show spectral signatures of ionized heavy elements, such as Si II, SI III, C IV, Si IV, and N V, arising in the immediate environment of these stars. The shortward-shifted lines in two (G191--B2B and 2111+49) of the three DA types showing metallic lines are tentatively interpreted as an indication of mass loss from these stars. The He-rich white dwarf shows the features due to C cV and He II, which also arise in the immediate environment of that star. Although the statistical sample presented here is limited, we tentatively suggest a temperature and effective gravity range (T/sub eff/> or approx. =20,000 K and log (g) < or approx. =8.0) in DA white dwarfs within which metallic lines are present either in the photosphere or in the halo of the stars. We examine the physical processes relevant to the appearance of such metallic lines. We tentatively propose that radiative levitation can explain the appearance of the observed lines in the hot DA white dwarfs, although the role of radiation forces in mass loss is not clear

  10. Comparison of muscle/lean mass measurement methods: correlation with functional and biochemical testing.

    Science.gov (United States)

    Buehring, B; Siglinsky, E; Krueger, D; Evans, W; Hellerstein, M; Yamada, Y; Binkley, N

    2018-03-01

    DXA-measured lean mass is often used to assess muscle mass but has limitations. Thus, we compared DXA lean mass with two novel methods-bioelectric impedance spectroscopy and creatine (methyl-d3) dilution. The examined methodologies did not measure lean mass similarly and the correlation with muscle biomarkers/function varied. Muscle function tests predict adverse health outcomes better than lean mass measurement. This may reflect limitations of current mass measurement methods. Newer approaches, e.g., bioelectric impedance spectroscopy (BIS) and creatine (methyl-d3) dilution (D3-C), may more accurately assess muscle mass. We hypothesized that BIS and D3-C measured muscle mass would better correlate with function and bone/muscle biomarkers than DXA measured lean mass. Evaluations of muscle/lean mass, function, and serum biomarkers were obtained in older community-dwelling adults. Mass was assessed by DXA, BIS, and orally administered D3-C. Grip strength, timed up and go, and jump power were examined. Potential muscle/bone serum biomarkers were measured. Mass measurements were compared with functional and serum data using regression analyses; differences between techniques were determined by paired t tests. Mean (SD) age of the 112 (89F/23M) participants was 80.6 (6.0) years. The lean/muscle mass assessments were correlated (.57-.88) but differed (p Lean mass measures were unrelated to the serum biomarkers measured. These three methodologies do not similarly measure muscle/lean mass and should not be viewed as being equivalent. Functional tests assessing maximal muscle strength/power (grip strength and jump power) correlated with all mass measures whereas gait speed was not. None of the selected serum measures correlated with mass. Efforts to optimize muscle mass assessment and identify their relationships with health outcomes are needed.

  11. Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women : the Health ABC Study

    NARCIS (Netherlands)

    Visser, Marjolein; Pahor, Marco; Taaffe, Dennis R; Goodpaster, Bret H; Simonsick, Eleanor M; Newman, Anne B; Nevitt, Michael; Harris, Tamara B

    BACKGROUND: A decline in muscle mass and muscle strength characterizes normal aging. As clinical and animal studies show a relationship between higher cytokine levels and low muscle mass, the aim of this study was to investigate whether markers of inflammation are associated with muscle mass and

  12. Fat-Free Mass and Skeletal Muscle Mass Five Years After Bariatric Surgery.

    Science.gov (United States)

    Davidson, Lance E; Yu, Wen; Goodpaster, Bret H; DeLany, James P; Widen, Elizabeth; Lemos, Thaisa; Strain, Gladys W; Pomp, Alfons; Courcoulas, Anita P; Lin, Susan; Janumala, Isaiah; Thornton, John C; Gallagher, Dympna

    2018-07-01

    This study investigated changes in fat-free mass (FFM) and skeletal muscle 5 years after surgery in participants from the Longitudinal Assessment of Bariatric Surgery-2 trial. A three-compartment model assessed FFM, and whole-body magnetic resonance imaging (MRI) quantified skeletal muscle mass prior to surgery (T0) and 1 year (T1), 2 years (T2), and 5 years (T5) postoperatively in 93 patients (85% female; 68% Caucasian; age 44.2 ± 11.6 years) who underwent gastric bypass (RYGB), sleeve gastrectomy, or adjustable gastric band. Repeated-measures mixed models were used to analyze the data. Significant weight loss occurred across all surgical groups in females from T0 to T1. FFM loss from T0 to T1 was greater after RYGB (mean ± SE: -6.9 ± 0.6 kg) than adjustable gastric band (-3.5 ± 1.4 kg; P FFM (-3.3 ± 0.7 kg; P FFM loss while maintaining FFM and skeletal muscle from T1 to T5. Between 1 and 5 years following common bariatric procedures, FFM and skeletal muscle are maintained or decrease minimally. The changes observed in FFM and muscle during the follow-up phase may be consistent with aging. © 2018 The Obesity Society.

  13. Association of low back pain with muscle stiffness and muscle mass of the lumbar back muscles, and sagittal spinal alignment in young and middle-aged medical workers.

    Science.gov (United States)

    Masaki, Mitsuhiro; Aoyama, Tomoki; Murakami, Takashi; Yanase, Ko; Ji, Xiang; Tateuchi, Hiroshige; Ichihashi, Noriaki

    2017-11-01

    Muscle stiffness of the lumbar back muscles in low back pain (LBP) patients has not been clearly elucidated because quantitative assessment of the stiffness of individual muscles was conventionally difficult. This study aimed to examine the association of LBP with muscle stiffness assessed using ultrasonic shear wave elastography (SWE) and muscle mass of the lumbar back muscle, and spinal alignment in young and middle-aged medical workers. The study comprised 23 asymptomatic medical workers [control (CTR) group] and 9 medical workers with LBP (LBP group). Muscle stiffness and mass of the lumbar back muscles (lumbar erector spinae, multifidus, and quadratus lumborum) in the prone position were measured using ultrasonic SWE. Sagittal spinal alignment in the standing and prone positions was measured using a Spinal Mouse. The association with LBP was investigated by multiple logistic regression analysis with a forward selection method. The analysis was conducted using the shear elastic modulus and muscle thickness of the lumbar back muscles, and spinal alignment, age, body height, body weight, and sex as independent variables. Multiple logistic regression analysis showed that muscle stiffness of the lumbar multifidus muscle and body height were significant and independent determinants of LBP, but that muscle mass and spinal alignment were not. Muscle stiffness of the lumbar multifidus muscle in the LBP group was significantly higher than that in the CTR group. The results of this study suggest that LBP is associated with muscle stiffness of the lumbar multifidus muscle in young and middle-aged medical workers. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Testing the Paradigm that Ultraluminous X-Ray Sources as a Class Represent Accreting Intermediate-Mass Black Holes

    Science.gov (United States)

    Berghea, C. T.; Weaver, K. A.; Colbert, E. J. M.; Roberts, T. P.

    2008-11-01

    To test the idea that ultraluminous X-ray sources (ULXs) in external galaxies represent a class of accreting intermediate-mass black holes (IMBHs), we have undertaken a program to identify ULXs and a lower luminosity X-ray comparison sample with the highest quality data in the Chandra archive. We establish as a general property of ULXs that the most X-ray-luminous objects possess the flattest X-ray spectra (in the Chandra bandpass). No prior sample studies have established the general hardening of ULX spectra with luminosity. This hardening occurs at the highest luminosities (absorbed luminosity >=5 × 1039 erg s-1) and is in line with recent models arguing that ULXs are actually stellar mass black holes. From spectral modeling, we show that the evidence originally taken to mean that ULXs are IMBHs—i.e., the "simple IMBH model"—is nowhere near as compelling when a large sample of ULXs is looked at properly. During the last couple of years, XMM-Newton spectroscopy of ULXs has to a large extent begun to negate the simple IMBH model based on fewer objects. We confirm and expand these results, which validates the XMM-Newton work in a broader sense with independent X-ray data. We find that (1) cool-disk components are present with roughly equal probability and total flux fraction for any given ULX, regardless of luminosity, and (2) cool-disk components extend below the standard ULX luminosity cutoff of 1039 erg s-1, down to our sample limit of 1038.3 erg s-1. The fact that cool-disk components are not correlated with luminosity damages the argument that cool disks indicate IMBHs in ULXs, for which strong statistical support was never found.

  15. A low muscle mass increases mortality in compensated cirrhotic patients with sepsis.

    Science.gov (United States)

    Lucidi, Cristina; Lattanzi, Barbara; Di Gregorio, Vincenza; Incicco, Simone; D'Ambrosio, Daria; Venditti, Mario; Riggio, Oliviero; Merli, Manuela

    2018-05-01

    Severe infections and muscle wasting are both associated to poor outcome in cirrhosis. A possible synergic effect of these two entities in cirrhotic patients has not been previously investigated. We aimed at analysing if a low muscle mass may deteriorate the outcome of cirrhotic patients with sepsis. Consecutive cirrhotic patients hospitalized for sepsis were enrolled in the study. Patients were classified for the severity of liver impairment (Child-Pugh class) and for the presence of "low muscle mass" (mid-arm muscle circumferencelow muscle mass. In patients with and without low muscle mass, severity of liver disease and characteristics of infections were similar. Mortality tended to be higher in patients with low muscle mass (47% vs 26%, P = .06). A multivariate analysis selected low muscle mass (P low muscle mass compared with those without (50% vs 16%; P = .01). The mortality rate and the incidence of complications in malnourished patients classified in Child-Pugh A-B were similar to those Child-Pugh C. Low muscle mass worsen prognosis in cirrhotic patients with severe infections. This is particularly evident in patients with Child A-B cirrhosis in whom the coexistence of low muscle mass and sepsis caused a negative impact on mortality similar to that observable in all Child C patients with sepsis. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  16. Alfacalcidol improves muscle power, muscle function and balance in elderly patients with reduced bone mass.

    Science.gov (United States)

    Schacht, E; Ringe, Johann D

    2012-01-01

    We investigated the effect of daily therapy with 1 mcg alfacalcidol (Doss(®)-TEVA/AWD-pharma) on muscle power, muscle function, balance performance and fear of falls in an open, multi-centered, uncontrolled, prospective study on a cohort of patients with reduced bone mass. Among the 2,097 participants, 87.1% were post-menopausal women and 12.9% were men. Mean age was 74.8 years and mean body mass index (BMI) 26.3 kg/m². A total of 75.3% of the study population had osteoporosis, 81% a diagnosis of "increased risk of falls" and 70.1% had a creatinine clearance (CrCl) of power tests at onset and after 3 and 6 months: the timed up and go test (TUG) and the chair rising test (CRT). At baseline and after 6 months, participants performed the tandem gait test (TGT) and filled out a questionnaire evaluating fear of falling. Successful performance in the muscle tests is associated with a significantly lower risk of falls and non-vertebral fractures in elderly patients (successful test performance: TUG ≤ 10 s (sec), CRT ≤ 10 s, TGT ≥ 8 steps). A significant improvement in the performance of the two muscle tests was proved already after 3 months of treatment with alfacalcidol and further increased by the end of the therapeutic intervention. There were significant increases in the number of participants able to successfully perform the tests: 24.6% at baseline and 46.3% at the end of trial for the TUG (P balance test (TGT) increased from 36.0% at onset to 58.6% at the end of the trial (P power, muscle function and balance and reduces fear of falls. The significant improvement in the three muscle and balance tests and fear of falls may have a preventative effect on falls and fractures. We suggest that the quantitative risk tests used in this study could be reliable surrogate parameters for the risk of falls and fractures in elderly patients.

  17. Relationship between oxidative stress and muscle mass loss in early postmenopause: an exploratory study.

    Science.gov (United States)

    Zacarías-Flores, Mariano; Sánchez-Rodríguez, Martha A; García-Anaya, Oswaldo Daniel; Correa-Muñoz, Elsa; Mendoza-Núñez, Víctor Manuel

    2018-04-09

    Endocrine changes due to menopause have been associated to oxidative stress and muscle mass loss. The study objective was to determine the relationship between both variables in early postmenopause. An exploratory, cross-sectional study was conducted in 107 pre- and postmenopausal women (aged 40-57 years). Levels of serum lipid peroxides and uric acid and enzymes superoxide dismutase and glutathione peroxidase, as well as total plasma antioxidant capacity were measured as oxidative stress markers. Muscle mass using bioelectrical impedance and muscle strength using dynamometry were also measured. Muscle mass, skeletal muscle index, fat-free mass, and body mass index were calculated. More than 90% of participants were diagnosed with overweight or obesity. Postmenopausal women had lower values of muscle mass and strength markers, with a negative correlation between lipid peroxide level and skeletal muscle index (r= -0.326, p<.05), and a positive correlation between uric acid and skeletal muscle index (r=0.295, p<.05). A multivariate model including oxidative stress markers, age, and waist circumference showed lipid peroxide level to be the main contributor to explain the decrease in skeletal muscle mass in postmenopause, since for every 0.1μmol/l increase in lipid peroxide level, skeletal muscle index decreases by 3.03 units. Our findings suggest an association between increased oxidative stress and muscle mass loss in early postmenopause. Copyright © 2018 SEEN y SED. Publicado por Elsevier España, S.L.U. All rights reserved.

  18. The effect Mat Pilates practice on muscle mass in elderly women

    Directory of Open Access Journals (Sweden)

    Leliz Cristina Sampaio Queiroz

    2016-01-01

    Full Text Available Objective: to verify that the Mat Pilates practice increases muscle mass in elderly women. Methods: quasi-experimental study with primary data collection and with a convenience sample. The muscle mass of 43 elderly was evaluated for 11 weeks, by calculating the arm muscle area, before and after the intervention. Results:statistically significant difference was observed (p<0.002 between the average value of the arm muscle area, before (35.56cm2 and after the exercises (42.72cm2. Conclusion: mat Pilates program generates positive effect on increasing the muscle mass of elderly.

  19. Creatine Loading Does Not Preserve Muscle Mass or Strength During Leg Immobilization in Healthy, Young Males

    NARCIS (Netherlands)

    Backx, Evelien M.P.; Hangelbroek, Roland; Snijders, Tim; Verscheijden, Marie Louise; Verdijk, Lex B.; Groot, de Lisette C.P.G.M.; Loon, van Luc J.C.

    2017-01-01

    Background: A short period of leg immobilization leads to rapid loss of muscle mass and strength. Creatine supplementation has been shown to increase lean body mass in active individuals and can be used to augment gains in muscle mass and strength during prolonged resistance-type exercise

  20. Correlation between Body Mass Index, Gender, and Skeletal Muscle Mass Cut off Point in Bandung

    Directory of Open Access Journals (Sweden)

    Richi Hendrik Wattimena

    2017-09-01

    Full Text Available Objective: To determine the average skeletal muscle mass (SMM value in young adults as a reference population; to analyze the correlation of gender, and body mass index to the cut off point; and to determine skeletal muscle mass cut off points of population in Bandung, Indonesia. Methods: This was a cross-sectional study involving 199 participants, 122 females and 77 males. The sampling technique used was the multistage random sampling. The participants were those who lived in four major regions in Bandung, Indonesia: Sukajadi, Cicadas, Buah Batu, and Cibaduyut. Results: The average appendicular skeletal mass index (ASMI in females and males based on body mass index (BMI were identified. The average ASMI values for normal BMI in females was 5.982±0.462 kg/m2 while the average ASMI values normal BMI for males was 7.581±0.744 kg/m2 Conclusions: A correlation between BMI and ASMI that was considered statistically significant was found in females (0.7712; p<0.05 and a very significant correlation was seen in males (0.870; p<0.05. The cut off points were defined by the normal BMI, which were 5.059 for females and 6.093 for males.

  1. EVOLUTION OF MASSIVE PROTOSTARS VIA DISK ACCRETION

    International Nuclear Information System (INIS)

    Hosokawa, Takashi; Omukai, Kazuyuki; Yorke, Harold W.

    2010-01-01

    Mass accretion onto (proto-)stars at high accretion rates M-dot * > 10 -4 M sun yr -1 is expected in massive star formation. We study the evolution of massive protostars at such high rates by numerically solving the stellar structure equations. In this paper, we examine the evolution via disk accretion. We consider a limiting case of 'cold' disk accretion, whereby most of the stellar photosphere can radiate freely with negligible backwarming from the accretion flow, and the accreting material settles onto the star with the same specific entropy as the photosphere. We compare our results to the calculated evolution via spherically symmetric accretion, the opposite limit, whereby the material accreting onto the star contains the entropy produced in the accretion shock front. We examine how different accretion geometries affect the evolution of massive protostars. For cold disk accretion at 10 -3 M sun yr -1 , the radius of a protostar is initially small, R * ≅ a few R sun . After several solar masses have accreted, the protostar begins to bloat up and for M * ≅ 10 M sun the stellar radius attains its maximum of 30-400 R sun . The large radius ∼100 R sun is also a feature of spherically symmetric accretion at the same accreted mass and accretion rate. Hence, expansion to a large radius is a robust feature of accreting massive protostars. At later times, the protostar eventually begins to contract and reaches the zero-age main sequence (ZAMS) for M * ≅ 30 M sun , independent of the accretion geometry. For accretion rates exceeding several 10 -3 M sun yr -1 , the protostar never contracts to the ZAMS. The very large radius of several hundreds R sun results in the low effective temperature and low UV luminosity of the protostar. Such bloated protostars could well explain the existence of bright high-mass protostellar objects, which lack detectable H II regions.

  2. Supplemental protein in support of muscle mass and health: advantage whey.

    Science.gov (United States)

    Devries, Michaela C; Phillips, Stuart M

    2015-03-01

    Skeletal muscle is an integral body tissue playing key roles in strength, performance, physical function, and metabolic regulation. It is essential for athletes to ensure that they have optimal amounts of muscle mass to ensure peak performance in their given sport. However, the role of maintaining muscle mass during weight loss and as we age is an emerging concept, having implications in chronic disease prevention, functional capacity, and quality of life. Higher-protein diets have been shown to: (1) promote gains in muscle mass, especially when paired with resistance training; (2) spare muscle mass loss during caloric restriction; and (3) attenuate the natural loss of muscle mass that accompanies aging. Protein quality is important to the gain and maintenance of muscle mass. Protein quality is a function of protein digestibility, amino acid content, and the resulting amino acid availability to support metabolic function. Whey protein is one of the highest-quality proteins given its amino acid content (high essential, branched-chain, and leucine amino acid content) and rapid digestibility. Consumption of whey protein has a robust ability to stimulate muscle protein synthesis. In fact, whey protein has been found to stimulate muscle protein synthesis to a greater degree than other proteins such as casein and soy. This review examines the existing data supporting the role for protein consumption, with an emphasis on whey protein, in the regulation of muscle mass and body composition in response to resistance training, caloric restriction, and aging. © 2015 Institute of Food Technologists®

  3. A New Equation to Estimate Muscle Mass from Creatinine and Cystatin C.

    Directory of Open Access Journals (Sweden)

    Sun-wook Kim

    Full Text Available With evaluation for physical performance, measuring muscle mass is an important step in detecting sarcopenia. However, there are no methods to estimate muscle mass from blood sampling.To develop a new equation to estimate total-body muscle mass with serum creatinine and cystatin C level, we designed a cross-sectional study with separate derivation and validation cohorts. Total body muscle mass and fat mass were measured using dual-energy x-ray absorptiometry (DXA in 214 adults aged 25 to 84 years who underwent physical checkups from 2010 to 2013 in a single tertiary hospital. Serum creatinine and cystatin C levels were also examined.Serum creatinine was correlated with muscle mass (P < .001, and serum cystatin C was correlated with body fat mass (P < .001 after adjusting glomerular filtration rate (GFR. After eliminating GFR, an equation to estimate total-body muscle mass was generated and coefficients were calculated in the derivation cohort. There was an agreement between muscle mass calculated by the novel equation and measured by DXA in both the derivation and validation cohort (P < .001, adjusted R2 = 0.829, β = 0.95, P < .001, adjusted R2 = 0.856, β = 1.03, respectively.The new equation based on serum creatinine and cystatin C levels can be used to estimate total-body muscle mass.

  4. RADIATIVELY EFFICIENT MAGNETIZED BONDI ACCRETION

    International Nuclear Information System (INIS)

    Cunningham, Andrew J.; Klein, Richard I.; McKee, Christopher F.; Krumholz, Mark R.; Teyssier, Romain

    2012-01-01

    We have carried out a numerical study of the effect of large-scale magnetic fields on the rate of accretion from a uniform, isothermal gas onto a resistive, stationary point mass. Only mass, not magnetic flux, accretes onto the point mass. The simulations for this study avoid complications arising from boundary conditions by keeping the boundaries far from the accreting object. Our simulations leverage adaptive refinement methodology to attain high spatial fidelity close to the accreting object. Our results are particularly relevant to the problem of star formation from a magnetized molecular cloud in which thermal energy is radiated away on timescales much shorter than the dynamical timescale. Contrary to the adiabatic case, our simulations show convergence toward a finite accretion rate in the limit in which the radius of the accreting object vanishes, regardless of magnetic field strength. For very weak magnetic fields, the accretion rate first approaches the Bondi value and then drops by a factor of ∼2 as magnetic flux builds up near the point mass. For strong magnetic fields, the steady-state accretion rate is reduced by a factor of ∼0.2 β 1/2 compared to the Bondi value, where β is the ratio of the gas pressure to the magnetic pressure. We give a simple expression for the accretion rate as a function of the magnetic field strength. Approximate analytic results are given in the Appendices for both time-dependent accretion in the limit of weak magnetic fields and steady-state accretion for the case of strong magnetic fields.

  5. RADIATIVELY EFFICIENT MAGNETIZED BONDI ACCRETION

    Energy Technology Data Exchange (ETDEWEB)

    Cunningham, Andrew J.; Klein, Richard I. [Lawrence Livermore National Laboratory, Livermore, CA 94550 (United States); McKee, Christopher F. [Department of Astronomy, University of California Berkeley, Berkeley, CA 94720 (United States); Krumholz, Mark R. [Department of Astronomy and Astrophysics, University of California Santa Cruz, Santa Cruz, CA 94560 (United States); Teyssier, Romain, E-mail: ajcunn@gmail.com [Service d' Astrophysique, CEA Saclay, 91191 Gif-sur-Yvette (France)

    2012-01-10

    We have carried out a numerical study of the effect of large-scale magnetic fields on the rate of accretion from a uniform, isothermal gas onto a resistive, stationary point mass. Only mass, not magnetic flux, accretes onto the point mass. The simulations for this study avoid complications arising from boundary conditions by keeping the boundaries far from the accreting object. Our simulations leverage adaptive refinement methodology to attain high spatial fidelity close to the accreting object. Our results are particularly relevant to the problem of star formation from a magnetized molecular cloud in which thermal energy is radiated away on timescales much shorter than the dynamical timescale. Contrary to the adiabatic case, our simulations show convergence toward a finite accretion rate in the limit in which the radius of the accreting object vanishes, regardless of magnetic field strength. For very weak magnetic fields, the accretion rate first approaches the Bondi value and then drops by a factor of {approx}2 as magnetic flux builds up near the point mass. For strong magnetic fields, the steady-state accretion rate is reduced by a factor of {approx}0.2 {beta}{sup 1/2} compared to the Bondi value, where {beta} is the ratio of the gas pressure to the magnetic pressure. We give a simple expression for the accretion rate as a function of the magnetic field strength. Approximate analytic results are given in the Appendices for both time-dependent accretion in the limit of weak magnetic fields and steady-state accretion for the case of strong magnetic fields.

  6. Muscle Mass Depletion Associated with Poor Outcome of Sepsis in the Emergency Department.

    Science.gov (United States)

    Lee, YoonJe; Park, Hyun Kyung; Kim, Won Young; Kim, Myung Chun; Jung, Woong; Ko, Byuk Sung

    2018-05-08

    Muscle mass depletion has been suggested to predict morbidity and mortality in various diseases. However, it is not well known whether muscle mass depletion is associated with poor outcome in sepsis. We hypothesized that muscle mass depletion is associated with poor outcome in sepsis. Retrospective observational study was conducted in an emergency department during a 9-year period. Medical records of 627 patients with sepsis were reviewed. We divided the patients into 2 groups according to 28-day mortality and compared the presence of muscle mass depletion assessed by the cross-sectional area of the psoas muscle at the level of the third lumbar vertebra on abdomen CT scans. Univariate and multivariate logistic regression analyses were conducted to examine the association of scarcopenia on the outcome of sepsis. A total of 274 patients with sepsis were finally included in the study: 45 (16.4%) did not survive on 28 days and 77 patients (28.1%) were identified as having muscle mass depletion. The presence of muscle mass depletion was independently associated with 28-day mortality on multivariate logistic analysis (OR 2.79; 95% CI 1.35-5.74, p = 0.01). Muscle mass depletion evaluated by CT scan was associated with poor outcome of sepsis patients. Further studies on the appropriateness of specific treatment for muscle mass depletion with sepsis are needed. © 2018 S. Karger AG, Basel.

  7. Relationships of 35 lower limb muscles to height and body mass quantified using MRI.

    Science.gov (United States)

    Handsfield, Geoffrey G; Meyer, Craig H; Hart, Joseph M; Abel, Mark F; Blemker, Silvia S

    2014-02-07

    Skeletal muscle is the most abundant tissue in the body and serves various physiological functions including the generation of movement and support. Whole body motor function requires adequate quantity, geometry, and distribution of muscle. This raises the question: how do muscles scale with subject size in order to achieve similar function across humans? While much of the current knowledge of human muscle architecture is based on cadaver dissection, modern medical imaging avoids limitations of old age, poor health, and limited subject pool, allowing for muscle architecture data to be obtained in vivo from healthy subjects ranging in size. The purpose of this study was to use novel fast-acquisition MRI to quantify volumes and lengths of 35 major lower limb muscles in 24 young, healthy subjects and to determine if muscle size correlates with bone geometry and subject parameters of mass and height. It was found that total lower limb muscle volume scales with mass (R(2)=0.85) and with the height-mass product (R(2)=0.92). Furthermore, individual muscle volumes scale with total muscle volume (median R(2)=0.66), with the height-mass product (median R(2)=0.61), and with mass (median R(2)=0.52). Muscle volume scales with bone volume (R(2)=0.75), and muscle length relative to bone length is conserved (median s.d.=2.1% of limb length). These relationships allow for an arbitrary subject's individual muscle volumes to be estimated from mass or mass and height while muscle lengths may be estimated from limb length. The dataset presented here can further be used as a normative standard to compare populations with musculoskeletal pathologies. © 2013 Published by Elsevier Ltd.

  8. Non-Hodgkin lymphoma in skeletal muscle manifesting as homogeneous masses with CT attenuation similar to muscle

    International Nuclear Information System (INIS)

    Panicek, D.M.; Lautin, J.L.; Schwartz, L.H.; Castellino, R.A.

    1997-01-01

    Two cases are presented of masses in muscle due to non-Hodgkin lymphoma (NHL) that were homogeneous and isoattenuating to normal muscle on CT. In each case, the mass was clinically suspected of representing soft tissue sarcoma. However, the masses were relatively inapparent on CT, being visible predominantly as mass effect - an appearance unlike that of soft tissue sarcomas. It is important to be aware that NHL in muscle can be difficult to detect at CT, even with intravenous contrast enhancement; therefore, a clinically apparent mass should not be dismissed on the basis of an apparently unremarkable CT scan of the region. Such findings should suggest the diagnosis of NHL rather than sarcoma. (orig.)

  9. The Intriguing Regulators of Muscle Mass in Sarcopenia and Muscular Dystrophy

    OpenAIRE

    Sakuma, Kunihiro; Aoi, Wataru; Yamaguchi, Akihiko

    2014-01-01

    Recent advances in our understanding of the biology of muscle have led to new interest in the pharmacological treatment of muscle wasting. Loss of muscle mass and increased intramuscular fibrosis occur in both sarcopenia and muscular dystrophy. Several regulators (mammalian target of rapamycin, serum response factor, atrogin-1, myostatin, etc.) seem to modulate protein synthesis and degradation or transcription of muscle-specific genes during both sarcopenia and muscular dystrophy. This revie...

  10. Comparison of skeletal muscle mass to fat-free mass ratios among different ethnic groups.

    Science.gov (United States)

    Abe, T; Bemben, M G; Kondo, M; Kawakami, Y; Fukunaga, T

    2012-01-01

    Asians seem to have less skeletal muscle mass (SMM) than other ethnic groups, but it is not clear whether relative SMM, i.e., SMM / height square or SMM to fat-free mass (FFM) ratio, differs among different ethnic groups at the same level of body mass index (BMI). To compare the SMM to fat-free mass (FFM) ratio as well as anthropometric variables and body composition among 3 ethnic groups. Three hundred thirty-nine Japanese, 343 Brazilian, and 183 German men and women were recruited for this cross-sectional study. Muscle thickness (MTH) and subcutaneous fat thickness (FTH) were measured by ultrasound at nine sites on the anterior and posterior aspects of the body. FTH was used to estimate the body density, from which fat mass and fat-free mass (FFM) was calculated by using Brozek equation. Total SMM was estimated from ultrasound-derived prediction equations. Percentage body fat was similar among the ethnic groups in men, while Brazilians were higher than Japanese in women. In German men and women, absolute SMM and FFM were higher than in their Japanese and Brazilians counterparts. SMM index and SMM:FFM ratios were similar among the ethnic groups in women, excluding SMM:FFM ratio in Brazilian. In men, however, these relative values (SMM index and SMM:FFM ratio) were still higher in Germans. After adjusting for age and BMI, the SMM index and SMM:FFM ratios were lower in Brazilian men and women compared with the other two ethnic groups, while the SMM index and SMM:FFM ratios were similar in Japanese and German men and women, excluding SMM:FFM ratio in women. Our results suggest that relative SMM is not lower in Asian populations compared with European populations after adjusted by age and BMI.

  11. OPTICAL VARIABILITY OF THE ACCRETION DISK AROUND THE INTERMEDIATE-MASS BLACK HOLE ESO 243-49 HLX-1 DURING THE 2012 OUTBURST

    Energy Technology Data Exchange (ETDEWEB)

    Webb, N. A.; Godet, O.; Barret, D. [Université de Toulouse, UPS-OMP, IRAP, Toulouse (France); Wiersema, K. [University of Leicester, University Road, Leicester LE1 7RH (United Kingdom); Lasota, J.-P. [Institut d' Astrophysique de Paris, UMR 7095, CNRS, UPMC Université Paris 06, 98bis Boulevard Arago, F-75014 Paris (France); Farrell, S. A. [Sydney Institute for Astronomy, School of Physics, The University of Sydney, NSW 2006 (Australia); Maccarone, T. J. [Department of Physics, Box 41051, Texas Tech University, Lubbock TX 79409-1051 (United States); Servillat, M., E-mail: natalie.webb@irap.omp.eu [Laboratoire AIM (CEA/DSM/IRFU/SAp, CNRS, Université Paris Diderot), CEA Saclay, Bat. 709, F-91191 Gif-sur-Yvette (France)

    2014-01-01

    We present dedicated quasi-simultaneous X-ray (Swift) and optical (Very Large Telescope, V-, and R-band) observations of the intermediate-mass black hole candidate HLX-1 before and during the 2012 outburst. We show that the V-band magnitudes vary with time, thus proving that a portion of the observed emission originates in the accretion disk. Using the first quiescent optical observations of HLX-1, we show that the stellar population surrounding HLX-1 is fainter than V ∼ 25.1 and R ∼ 24.2. We show that the optical emission may increase before the X-ray emission consistent with the scenario proposed by Lasota et al. in which the regular outbursts could be related to the passage at periastron of a star circling the intermediate-mass black hole in an eccentric orbit, which triggers mass transfer into a quasi-permanent accretion disk around the black hole. Further, if there is indeed a delay in the X-ray emission we estimate the mass-transfer delivery radius to be ∼10{sup 11} cm.

  12. Creatine Supplementation and Skeletal Muscle Metabolism for Building Muscle Mass- Review of the Potential Mechanisms of Action.

    Science.gov (United States)

    Farshidfar, Farnaz; Pinder, Mark A; Myrie, Semone B

    2017-01-01

    Creatine, a very popular supplement among athletic populations, is of growing interest for clinical applications. Since over 90% of creatine is stored in skeletal muscle, the effect of creatine supplementation on muscle metabolism is a widely studied area. While numerous studies over the past few decades have shown that creatine supplementation has many favorable effects on skeletal muscle physiology and metabolism, including enhancing muscle mass (growth/hypertrophy); the underlying mechanisms are poorly understood. This report reviews studies addressing the mechanisms of action of creatine supplementation on skeletal muscle growth/hypertrophy. Early research proposed that the osmotic effect of creatine supplementation serves as a cellular stressor (osmosensing) that acts as an anabolic stimulus for protein synthesis signal pathways. Other reports indicated that creatine directly affects muscle protein synthesis via modulations of components in the mammalian target of rapamycin (mTOR) pathway. Creatine may also directly affect the myogenic process (formation of muscle tissue), by altering secretions of myokines, such as myostatin and insulin-like growth factor-1, and expressions of myogenic regulatory factors, resulting in enhanced satellite cells mitotic activities and differentiation into myofiber. Overall, there is still no clear understanding of the mechanisms of action regarding how creatine affects muscle mass/growth, but current evidence suggests it may exert its effects through multiple approaches, with converging impacts on protein synthesis and myogenesis. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  13. Bio-impedance analysis for appendicular skeletal muscle mass assessment in (pre-) frail elderly people

    NARCIS (Netherlands)

    Baar, van H.; Hulshof, P.J.M.; Tieland, C.A.B.; Groot, de C.P.G.M.

    2015-01-01

    Background & aims Screening populations for skeletal muscle mass (SMM) is important for early detection of sarcopenia. Our aim was to develop an age specific bio-impedance (BI) prediction equation for the assessment of appendicular skeletal muscle mass (ASMM) in (pre-) frail elderly people aged

  14. Does Skeletal Muscle Mass Influence Breast Cancer? Evaluating Mammary Tumorigenesis and Progression Genetically Hyper-Muscular Mice

    National Research Council Canada - National Science Library

    Zimmers, Teresa

    2006-01-01

    .... Mice lacking the skeletal muscle-specific muscle growth inhibitor myostatin and mice expressing a dominant negative form of the myostatin receptor, Activin Receptor Type IIB, display heightened muscle mass...

  15. Relationship of Muscle Mass Determined by DEXA with Spirometric Results in Healthy Individuals.

    Science.gov (United States)

    Martín Holguera, Rafael; Turrión Nieves, Ana Isabel; Rodríguez Torres, Rosa; Alonso, María Concepción

    2017-07-01

    Muscle mass maybe a determining factor in the variability of spirometry results in individuals of the same sex and age who have similar anthropometric characteristics. The aim of this study was to determine the association between spirometric results from healthy individuals and their muscle mass assessed by dual energy X-ray absorptiometry (DEXA). A sample of 161 women and 144 men, all healthy non-smokers, was studied. Ages ranged from18 to77years. For each subject, spirometry results and total and regional lean mass values obtained by full body DEXA were recorded. A descriptive analysis of the variables and a regression analysis were performed to study the relationship between spirometric variables and lean body mass, correcting for age and body mass index (BMI). In both sexes all muscle mass variables correlated positively and significantly with spirometric variables, and to a greater extent in men. After partial adjustment of correlations by age and BMI, the factor which best explains the spirometric variables is the total lean body mass in men, and trunk lean body mass in women. In men, muscle mass in the lower extremities is most closely associated with spirometric results. In women, it is the muscle mass of the trunk. In both sexes muscle mass mainly affects FEV 1 . Copyright © 2016 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved.

  16. Accretion onto a Kiselev black hole

    Energy Technology Data Exchange (ETDEWEB)

    Jiao, Lei [Hebei University, College of Physical Science and Technology, Baoding (China); Yang, Rongjia [Hebei University, College of Physical Science and Technology, Baoding (China); Hebei University, Hebei Key Lab of Optic-Electronic Information and Materials, Baoding (China)

    2017-05-15

    We consider accretion onto a Kiselev black hole. We obtain the fundamental equations for accretion without the back-reaction. We determine the general analytic expressions for the critical points and the mass accretion rate and find the physical conditions the critical points should fulfill. The case of a polytropic gas are discussed in detail. It turns out that the quintessence parameter plays an important role in the accretion process. (orig.)

  17. Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia

    Science.gov (United States)

    Kim, Kyoung Min; Jang, Hak Chul; Lim, Soo

    2016-01-01

    Aging processes are inevitably accompanied by structural and functional changes in vital organs. Skeletal muscle, which accounts for 40% of total body weight, deteriorates quantitatively and qualitatively with aging. Skeletal muscle is known to play diverse crucial physical and metabolic roles in humans. Sarcopenia is a condition characterized by significant loss of muscle mass and strength. It is related to subsequent frailty and instability in the elderly population. Because muscle tissue is involved in multiple functions, sarcopenia is closely related to various adverse health outcomes. Along with increasing recognition of the clinical importance of sarcopenia, several international study groups have recently released their consensus on the definition and diagnosis of sarcopenia. In practical terms, various skeletal muscle mass indices have been suggested for assessing sarcopenia: appendicular skeletal muscle mass adjusted for height squared, weight, or body mass index. A different prevalence and different clinical implications of sarcopenia are highlighted by each definition. The discordances among these indices have emerged as an issue in defining sarcopenia, and a unifying definition for sarcopenia has not yet been attained. This review aims to compare these three operational definitions and to introduce an optimal skeletal muscle mass index that reflects the clinical implications of sarcopenia from a metabolic perspective. PMID:27334763

  18. Growth hormone mitigates loss of periosteal bone formation and muscle mass in disuse osteopenic rats

    DEFF Research Database (Denmark)

    Grubbe, M-C; Thomsen, Jesper Skovhus; Nyengaard, J R

    2014-01-01

    Growth hormone (GH) is a potent anabolic agent capable of increasing both bone and muscle mass. The aim was to investigate whether GH could counteract disuse-induced loss of bone and muscle mass in a rat model. Paralysis was induced by injecting 4 IU Botox (BTX) into the muscles of the right hind...... of periosteal BFR/BS (2-fold increase vs. BTX, Pmuscle mass (+29% vs. BTX, Pmuscle CSA (+11%, P=0.064). In conclusion, GH mitigates disuse......BMD, -13%, Pmuscle mass (-69%, Pmuscle cell cross sectional area (CSA) (-73%, P

  19. mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass

    Directory of Open Access Journals (Sweden)

    Mee-Sup Yoon

    2017-10-01

    Full Text Available Maintenance of skeletal muscle mass is regulated by the balance between anabolic and catabolic processes. Mammalian target of rapamycin (mTOR is an evolutionarily conserved serine/threonine kinase, and is known to play vital roles in protein synthesis. Recent findings have continued to refine our understanding of the function of mTOR in maintaining skeletal muscle mass. mTOR controls the anabolic and catabolic signaling of skeletal muscle mass, resulting in the modulation of muscle hypertrophy and muscle wastage. This review will highlight the fundamental role of mTOR in skeletal muscle growth by summarizing the phenotype of skeletal-specific mTOR deficiency. In addition, the evidence that mTOR is a dual regulator of anabolism and catabolism in skeletal muscle mass will be discussed. A full understanding of mTOR signaling in the maintenance of skeletal muscle mass could help to develop mTOR-targeted therapeutics to prevent muscle wasting.

  20. High risk of malnutrition is associated with low muscle mass in older hospitalized patients - a prospective cohort study.

    Science.gov (United States)

    Pierik, Vincent D; Meskers, Carel G M; Van Ancum, Jeanine M; Numans, Siger T; Verlaan, Sjors; Scheerman, Kira; Kruizinga, Roeliene C; Maier, Andrea B

    2017-06-05

    Malnutrition, low muscle strength and muscle mass are highly prevalent in older hospitalized patients and associated with adverse outcomes. Malnutrition may be a risk factor for developing low muscle mass. We aimed to investigate the association between the risk of malnutrition and 1) muscle strength and muscle mass at admission and 2) the change of muscle strength and muscle mass during hospitalization in older patients. The EMPOWER study included 378 patients aged seventy years or older who were acutely or electively admitted to four different wards of an academic teaching hospital in Amsterdam. Patients were grouped into low risk of malnutrition and high risk of malnutrition based on the Short Nutritional Assessment Questionnaire (SNAQ) score and were assessed for hand grip strength and muscle mass using hand held dynamometry respectively bioelectrical impedance analysis (BIA) within 48 h after admission and at day seven, or earlier at the day of discharge. Muscle mass was expressed as skeletal muscle mass, appendicular lean mass, fat free mass and the skeletal muscle index. The mean age of the patients was 79.7 years (SD 6.39), 48.9% were female. At admission, being at high risk of malnutrition was significantly associated with lower muscle mass (Odds Ratio, 95% CI, 0.90, 0.85-0.96), but not with muscle strength. Muscle strength and muscle mass did not change significantly during hospitalization in both groups. In older hospitalized patients, a high risk of malnutrition is associated with lower muscle mass at admission, but not with muscle strength nor with change of either muscle strength or muscle mass during hospitalization.

  1. A Solution to the Protostellar Accretion Problem

    OpenAIRE

    Padoan, Paolo; Kritsuk, Alexei; Norman, Michael L.; Nordlund, Ake

    2004-01-01

    Accretion rates of order 10^-8 M_\\odot/yr are observed in young protostars of approximately a solar mass with evidence of circumstellar disks. The accretion rate is significantly lower for protostars of smaller mass, approximately proportional to the second power of the stellar mass, \\dot{M}_accr\\propto M^2. The traditional view is that the observed accretion is the consequence of the angular momentum transport in isolated protostellar disks, controlled by disk turbulence or self--gravity. Ho...

  2. Hot Accretion onto Black Holes with Outflow

    Directory of Open Access Journals (Sweden)

    Park Myeong-Gu

    2018-01-01

    Full Text Available Classic Bondi accretion flow can be generalized to rotating viscous accretion flow. Study of hot accretion flow onto black holes show that its physical charateristics change from Bondi-like for small gas angular momentum to disk-like for Keperian gas angular momentum. Especially, the mass accretion rate divided by the Bondi accretion rate is proportional to the viscosity parameter alpha and inversely proportional to the gas angular momentum divided by the Keplerian angular momentum at the Bondi radius for gas angular momentum comparable to the Keplerian value. The possible presence of outflow will increase the mass inflow rate at the Bondi radius but decrease the mass accretion rate across the black hole horizon by many orders of magnitude. This implies that the growth history of supermassive black holes and their coevolution with host galaxies will be dramatically changed when the accreted gas has angular momentum or develops an outflow.

  3. Subclinical hypothyroidism has little influences on muscle mass or strength in elderly people.

    Science.gov (United States)

    Moon, Min Kyong; Lee, You Jin; Choi, Sung Hee; Lim, Soo; Yang, Eun Joo; Lim, Jae-Young; Paik, Nam-Jong; Kim, Ki Woong; Park, Kyong Soo; Jang, Hak C; Cho, Bo Youn; Park, Young Joo

    2010-08-01

    Sarcopenia, the age-related decline in muscle mass, affects the muscle strength and muscle quality, and these changes decrease functional capacity. The prevalence of thyroid dysfunction increases with age, and changes in thyroid hormone level lead to neuromuscular deficits. We investigated the effects of subclinical hypothyroidism on the muscle mass, strength or quality in elderly people. One thousand one hundred eighteen subjects aged > or = 65 yr were randomly selected from a local population and classified into a euthyroid (280 men and 358 women), subclinically hypothyroid (61 men and 75 women), or overtly hypothyroid (7 men and 16 women) group. Although women with subclinical hypothyroidism had a higher prevalence of sarcopenia, defined according to the ratio of appendicular skeletal muscle mass to the square of height, muscle mass, strength or quality did not differ in relation to thyroid status in men or in women. Multivariate analysis including age, diabetes, hypertension, acute coronary event, alcohol, smoking, presence of pain, physical activity score, and lipid profile, showed that thyroid-stimulating hormone level was not associated with muscle mass, strength or quality. In conclusion, subclinical hypothyroidism has little influences on muscle mass, strength or quality, and may not be associated with sarcopenia.

  4. Osteocalcin is necessary and sufficient to maintain muscle mass in older mice

    Directory of Open Access Journals (Sweden)

    Paula Mera

    2016-10-01

    Full Text Available Objective: A decrease in muscle protein turnover and therefore in muscle mass is a hallmark of aging. Because the circulating levels of the bone-derived hormone osteocalcin decline steeply during aging in mice, monkeys and humans we asked here whether this hormone might regulate muscle mass as mice age. Methods: We examined muscle mass and strength in mice lacking osteocalcin (Ocn−/− or its receptor in all cells (Gprc6a−/− or specifically in myofibers (Gprc6aMck−/− as well as in 9 month-old WT mice receiving exogenous osteocalcin for 28 days. We also examined protein synthesis in WT and Gprc6a−/− mouse myotubes treated with osteocalcin. Results: We show that osteocalcin signaling in myofibers is necessary to maintain muscle mass in older mice in part because it promotes protein synthesis in myotubes without affecting protein breakdown. We further show that treatment with exogenous osteocalcin for 28 days is sufficient to increase muscle mass of 9-month-old WT mice. Conclusion: This study uncovers that osteocalcin is necessary and sufficient to prevent age-related muscle loss in mice. Author Video: Author Video Watch what authors say about their articles Keywords: Osteocalcin, Muscle mass, Aging

  5. Improved skeletal muscle mass and strength after heavy strength training in very old individuals

    DEFF Research Database (Denmark)

    Bechshøft, Rasmus Leidesdorff; Malmgaard-Clausen, Nikolaj Mølkjær; Gliese, Bjørn

    2017-01-01

    , muscle fiber type distribution and size did not differ significantly between groups. We conclude that in protein supplemented very old individuals, heavy resistance training can increase muscle mass and strength, and that the relative improvement in mass is more pronounced when initial muscle mass is low.......Age-related loss of muscle mass and function represents personal and socioeconomic challenges. The purpose of this study was to determine the adaptation of skeletal musculature in very old individuals (83 + years) performing 12 weeks of heavy resistance training (3 ×/week) (HRT) compared to a non....... The increase in CSA is correlated inversely with the baseline level of CSA (R2 = 0.43, P muscle isometric strength, isokinetic peak torque and power increased significantly only in HRT by 10–15%, whereas knee extension one-repetition maximum (1 RM) improved by 91%. Physical functional tests...

  6. Skeletal muscle mass recovery from atrophy in IL-6 knockout mice.

    Science.gov (United States)

    Washington, T A; White, J P; Davis, J M; Wilson, L B; Lowe, L L; Sato, S; Carson, J A

    2011-08-01

    Skeletal muscle interleukin-6 (IL-6) expression is induced by continuous contraction, overload-induced hypertrophy and during muscle regeneration. The loss of IL-6 can alter skeletal muscle's growth and extracellular matrix remodelling response to overload-induced hypertrophy. Insulin-like growth factor-1 (IGF-1) gene expression and related signalling through Akt/mTOR is a critical regulator of muscle mass. The significance of IL-6 expression during the recovery from muscle atrophy is unclear. This study's purpose was to determine the effect of IL-6 loss on mouse gastrocnemius (GAS) muscle mass during recovery from hindlimb suspension (HS)-induced atrophy. Female C57BL/6 [wild type (WT)] and IL-6 knockout (IL-6 KO) mice at 10 weeks of age were assigned to control, HS or HS followed by normal cage ambulation groups. GAS muscle atrophy was induced by 10 days of HS. HS induced a 20% loss of GAS mass in both WT and IL-6 KO mice. HS+7 days of recovery restored WT GAS mass to cage-control values. GAS mass from IL-6 KO mice did not return to cage-control values until HS+14 days of recovery. Both IGF-1 mRNA expression and Akt/mTOR signalling were increased in WT muscle after 1 day of recovery. In IL-6 KO muscle, IGF-1 mRNA expression was decreased and Akt/mTOR signalling was not induced after 1 day of recovery. MyoD and myogenin mRNA expression were both induced in WT muscle after 1 day of recovery, but not in IL-6 KO muscle.   Muscle IL-6 expression appears important for the initial growth response during the recovery from disuse. © 2011 The Authors. Acta Physiologica © 2011 Scandinavian Physiological Society.

  7. Relation between body mass index percentile and muscle strength ...

    African Journals Online (AJOL)

    Noha Abdel Kader Abdel Kader Hasan

    2016-02-01

    Feb 1, 2016 ... Abstract Background: Muscle strength and endurance in children are very important to develop physical .... the Faculty of Physical Therapy, Cairo university, was used to ..... [9] Noelle G. Quantification of muscle fatigue in cerebral palsy and ... Bouckaert J. Physical fitness and physical activity in obese and.

  8. Influence of amino acids, dietary protein, and physical activity on muscle mass development in humans

    DEFF Research Database (Denmark)

    Dideriksen, Kasper; Reitelseder, Søren; Holm, Lars

    2013-01-01

    intake. Ingestion of excess protein exerts an unwanted load to the body and therefore, it is important to find the least amount of protein that provides the maximal hypertrophic stimulus. Hence, research has focused on revealing the relationship between protein intake (dose) and its resulting stimulation...... response dependent on the characteristics of the protein ingested. The effect of protein intake on muscle protein accretion can further be stimulated by prior exercise training. In the ageing population, physical training may counteract the development of "anabolic resistance" and restore the beneficial...

  9. Association between healthy diet and exercise and greater muscle mass in older adults.

    Science.gov (United States)

    Kim, Jinhee; Lee, Yunhwan; Kye, Seunghee; Chung, Yoon-Sok; Kim, Kwang-Min

    2015-05-01

    To examine the association between healthy diet and exercise, individually and combined, and low muscle mass in older Korean adults. Population-based cross-sectional study from the Fourth and Fifth Korea National Health and Nutrition Examination Surveys from 2008 to 2011. Community. Nationally representative sample aged 65 and older (1,486 men, 1,799 women) in the Republic of Korea. A food frequency questionnaire was used to determine frequency of food group consumption (meat, fish, eggs, legumes; vegetables; fruits). Participation in exercise (aerobic and resistance) was based on self-report. Combined healthy lifestyle factors were calculated as the number of recommendations met regarding consumption of food groups and exercise performed. Appendicular skeletal muscle mass (ASM) was measured using dual-energy X-ray absorptiometry, and low muscle mass was defined using the variable of ASM adjusted for weight. Logistic regression analysis was performed to examine the association between healthy lifestyle factors and low muscle mass, adjusting for sociodemographic characteristics and health-related variables. In women, after controlling for covariates, vegetable consumption (odds ratio (OR)=0.52, 95% confidence interval (CI)=0.30-0.89) and aerobic exercise (OR=0.62, 95% CI=0.39-1.00) were inversely associated with low muscle mass. Also, the odds of low muscle mass was lower in women with three or more healthy lifestyle factors versus none (OR=0.45, 95% CI=0.23-0.87). In men, there were no associations between food group consumption and exercise and low muscle mass. Older women who exercise and consume a healthy diet have lower odds of low muscle mass. Engaging in multiple healthy behaviors may be important in preventing low muscle mass in late life. © 2015, Copyright the Authors Journal compilation © 2015, The American Geriatrics Society.

  10. Decreased muscle mass in Korean subjects with intracranial arterial stenosis: The Kangbuk Samsung Health Study.

    Science.gov (United States)

    Jung, Ho-Jung; Jung, Hwanseok; Lee, Taeyoung; Kim, Jongho; Park, Jongsin; Kim, Hacsoo; Cho, Junghwan; Lee, Won-Young; Park, Sung-Woo; Rhee, Eun-Jung; Oh, Hyung-Geun

    2017-01-01

    Intracranial arterial stenosis (ICAS) is a common cause of ischemic stroke in Asians. Decreased muscle mass is one of the major causes of chronic disease in adults. The purpose of this study was to analyze the relationship between muscle mass and ICAS in Korean adults. For this study, we selected a total of 10,530 participants (mean age, 43.3 years; 8558 men) in a health screening program, for whom transcranial Doppler (TCD) ultrasound was used to detect >50% ICAS based on criteria modified from the stroke outcomes and neuroimaging of intracranial atherosclerosis trial. Body composition was evaluated by bioelectrical impedance analysis (BIA). Skeletal muscle index (SMI) was calculated with muscle mass/weight (kg) * 100. Among the total patient population, 322 (3.1%) subjects had ICAS. Subjects with ICAS were older, and had higher mean values for fasting glucose, body mass index and blood pressure compared with those without ICAS. Subjects with ICAS had significantly lower muscle mass, SMI and higher percent body fat compared with those without ICAS. In logistic regression analysis, the subjects in the highest tertile of muscle mass had the lowest odds ratio for ICAS with the lowest tertile group of muscle mass as the reference group even after adjusting for age, systolic blood pressure, fasting blood glucose, sex, smoking and exercise (OR 0.650, 95% CI 0.442-0.955). Subjects with ICAS had significantly decreased muscle mass compared with those without ICAS in Korean adults. The risk for ICAS was lower in subjects with higher muscle mass. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  11. Lipid remodeling and an altered membrane-associated proteome may drive the differential effects of EPA and DHA treatment on skeletal muscle glucose uptake and protein accretion.

    Science.gov (United States)

    Jeromson, Stewart; Mackenzie, Ivor; Doherty, Mary K; Whitfield, Phillip D; Bell, Gordon; Dick, James; Shaw, Andy; Rao, Francesco V; Ashcroft, Stephen P; Philp, Andrew; Galloway, Stuart D R; Gallagher, Iain; Hamilton, D Lee

    2018-06-01

    In striated muscle, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have differential effects on the metabolism of glucose and differential effects on the metabolism of protein. We have shown that, despite similar incorporation, treatment of C 2 C 12 myotubes (CM) with EPA but not DHA improves glucose uptake and protein accretion. We hypothesized that these differential effects of EPA and DHA may be due to divergent shifts in lipidomic profiles leading to altered proteomic profiles. We therefore carried out an assessment of the impact of treating CM with EPA and DHA on lipidomic and proteomic profiles. Fatty acid methyl esters (FAME) analysis revealed that both EPA and DHA led to similar but substantials changes in fatty acid profiles with the exception of arachidonic acid, which was decreased only by DHA, and docosapentanoic acid (DPA), which was increased only by EPA treatment. Global lipidomic analysis showed that EPA and DHA induced large alterations in the cellular lipid profiles and in particular, the phospholipid classes. Subsequent targeted analysis confirmed that the most differentially regulated species were phosphatidylcholines and phosphatidylethanolamines containing long-chain fatty acids with five (EPA treatment) or six (DHA treatment) double bonds. As these are typically membrane-associated lipid species we hypothesized that these treatments differentially altered the membrane-associated proteome. Stable isotope labeling by amino acids in cell culture (SILAC)-based proteomics of the membrane fraction revealed significant divergence in the effects of EPA and DHA on the membrane-associated proteome. We conclude that the EPA-specific increase in polyunsaturated long-chain fatty acids in the phospholipid fraction is associated with an altered membrane-associated proteome and these may be critical events in the metabolic remodeling induced by EPA treatment.

  12. Sarcopenia and Predictors of Skeletal Muscle Mass in Elderly Men With and Without Obesity

    Directory of Open Access Journals (Sweden)

    Katja Stoever MA

    2017-06-01

    Full Text Available Objectives: The aim of this study was to determine the variables which show the highest association with muscle mass and to identify the most important predictors for muscle mass in elderly men with and without sarcopenia. Methods: A total of 71 men participated, aged ≥65 years. Sarcopenia was assessed using the definition of the European Working Group on Sarcopenia in Older People with determining skeletal muscle index (SMI, hand-grip strength (HGS, and Short Physical Performance Battery. In addition, maximum strength at upper and lower extremities and physical activity were measured. Results: Strong correlations existed between SMI and gait speed, HGS, maximum isometric strength at leg and chest press. Physical activity showed low correlations with muscle strength. Regression analysis revealed HGS and gait speed as key predictors for SMI. Discussion: The recommendation is measuring gait speed and HGS in clinical practice at first followed by measuring muscle mass for determining sarcopenia.

  13. X-RAY PROPERTIES OF INTERMEDIATE-MASS BLACK HOLES IN ACTIVE GALAXIES. II. X-RAY-BRIGHT ACCRETION AND POSSIBLE EVIDENCE FOR SLIM DISKS

    International Nuclear Information System (INIS)

    Desroches, Louis-Benoit; Greene, Jenny E.; Ho, Luis C.

    2009-01-01

    We present X-ray properties of optically selected intermediate-mass (∼10 5 -10 6 M sun ) black holes (BHs) in active galactic nuclei (AGNs), using data from the Chandra X-Ray Observatory. Our observations are a continuation of a pilot study by Greene and Ho. Of the eight objects observed, five are detected with X-ray luminosities in the range L 0.5-2keV = 10 41 -10 43 erg s -1 , consistent with the previously observed sample. Objects with enough counts to extract a spectrum are well fit by an absorbed power law. We continue to find a range of soft photon indices 1 s -Γ s , consistent with previous AGN studies, but generally flatter than other narrow-line Seyfert 1 active nuclei (NLS1s). The soft photon index correlates strongly with X-ray luminosity and Eddington ratio, but does not depend on BH mass. There is no justification for the inclusion of any additional components, such as a soft excess, although this may be a function of the relative inefficiency of detecting counts above 2 keV in these relatively shallow observations. As a whole, the X-ray-to-optical spectral slope α ox is flatter than in more massive systems, even other NLS1s. Only X-ray-selected NLS1s with very high Eddington ratios share a similar α ox . This is suggestive of a physical change in the accretion structure at low masses and at very high accretion rates, possibly due to the onset of slim disks. Although the detailed physical explanation for the X-ray loudness of these intermediate-mass BHs is not certain, it is very striking that targets selected on the basis of optical properties should be so distinctly offset in their broader spectral energy distributions.

  14. Temporal variability of carbon and nutrient burial, sediment accretion, and mass accumulation over the past century in a carbonate platform mangrove forest of the Florida Everglades

    Science.gov (United States)

    Breithaupt, Joshua L.; Smoak, Joseph M.; Smith, Thomas J.; Sanders, Christian J.

    2014-10-01

    The objective of this research was to measure temporal variability in accretion and mass sedimentation rates (including organic carbon (OC), total nitrogen (TN), and total phosphorous (TP)) from the past century in a mangrove forest on the Shark River in Everglades National Park, USA. The 210Pb Constant Rate of Supply model was applied to six soil cores to calculate annual rates over the most recent 10, 50, and 100 year time spans. Our results show that rates integrated over longer timeframes are lower than those for shorter, recent periods of observation. Additionally, the substantial spatial variability between cores over the 10 year period is diminished over the 100 year record, raising two important implications. First, a multiple-decade assessment of soil accretion and OC burial provides a more conservative estimate and is likely to be most relevant for forecasting these rates relative to long-term processes of sea level rise and climate change mitigation. Second, a small number of sampling locations are better able to account for spatial variability over the longer periods than for the shorter periods. The site average 100 year OC burial rate, 123 ± 19 (standard deviation) g m-2 yr-1, is low compared with global mangrove values. High TN and TP burial rates in recent decades may lead to increased soil carbon remineralization, contributing to the low carbon burial rates. Finally, the strong correlation between OC burial and accretion across this site signals the substantial contribution of OC to soil building in addition to the ecosystem service of CO2 sequestration.

  15. Migration of accreting giant planets

    Science.gov (United States)

    Crida, A.; Bitsch, B.; Raibaldi, A.

    2016-12-01

    We present the results of 2D hydro simulations of giant planets in proto-planetary discs, which accrete gas at a more or less high rate. First, starting from a solid core of 20 Earth masses, we show that as soon as the runaway accretion of gas turns on, the planet is saved from type I migration : the gap opening mass is reached before the planet is lost into its host star. Furthermore, gas accretion helps opening the gap in low mass discs. Consequently, if the accretion rate is limited to the disc supply, then the planet is already inside a gap and in type II migration. We further show that the type II migration of a Jupiter mass planet actually depends on its accretion rate. Only when the accretion is high do we retrieve the classical picture where no gas crosses the gap and the planet follows the disc spreading. These results impact our understanding of planet migration and planet population synthesis models. The e-poster presenting these results in French can be found here: L'e-poster présentant ces résultats en français est disponible à cette adresse: http://sf2a.eu/semaine-sf2a/2016/posterpdfs/156_179_49.pdf.

  16. Deficits in muscle strength, mass, quality and mobility in people with chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Roig, Marc; Eng, Janice J; MacIntyre, Donna L

    2011-01-01

    PURPOSE: Midthigh intramuscular fat (IF), a feature of reduced muscle quality, is an important predictor of self-reported mobility loss in the elderly. This study compared measures of muscle strength, mass, IF, and mobility in patients with chronic obstructive pulmonary disease (COPD) and healthy...

  17. Levator claviculae muscle presenting as a hard clavicular mass: imaging study

    International Nuclear Information System (INIS)

    Ruiz Santiago, F.; Lopez Milena, G.; Tristan Fernandez, J.M.; Chamorro Santos, C.

    2001-01-01

    We report a case of levator claviculae muscle presenting clinically as a hard mass in the clavicular area due to angular deformity of this bone. To our knowledge, this is the first report where the anomalous muscle shows this clinical presentation. (orig.)

  18. Alterations in molecular muscle mass regulators after 8 days immobilizing Special Forces mission

    DEFF Research Database (Denmark)

    Jespersen, J. G.; Mikkelsen, Ulla Ramer; Nedergaard, A.

    2015-01-01

    In military operations, declined physical capacity can endanger the life of soldiers. During special support and reconnaissance (SSR) missions, Special Forces soldiers sustain 1-2 weeks full-body horizontal immobilization, which impairs muscle strength and performance. Adequate muscle mass and st...

  19. Immobilization/remobilization and the regulation of muscle mass

    Science.gov (United States)

    Almon, R. R.

    1983-01-01

    The relationship between animal body weight and the wet and dry weights of the soleus and EDL muscles was derived. Procedures were examined for tissue homogenization, fractionation, protein determination and DNA determination. A sequence of procedures and buffers were developed to carry out all analyses on one small muscle. This would yield a considerable increase in analytical strength associated with paired statistics. The proposed casting procedure which was to be used for immobilization was reexamined.

  20. The Impact of Low Muscle Mass Definition on the Prevalence of Sarcopenia in Older Australians

    Directory of Open Access Journals (Sweden)

    Solomon Yu

    2014-01-01

    Full Text Available Background. Sarcopenia is the presence of low muscle mass and low muscle function. The aim of this study was to establish cutoffs for low muscle mass using three published methods and to compare the prevalence of sarcopenia in older Australians. Methods. Gender specific cutoffs levels were identified for low muscle mass using three different methods. Low grip strength was determined using established cutoffs of <30 kg for men and <20 kg for women to estimate the prevalence of sarcopenia. Results. Gender specific cutoffs levels for low muscle mass identified were (a <6.89 kg/m2 for men and <4.32 kg/m2 for women, <2 standard deviation (SD of a young reference population; (b <7.36 kg/m2 for men and <5.81 kg/m2 for women from the lowest 20% percentile of the older group; and (c <−2.15 for men and <−1.42 for women from the lowest 20% of the residuals of linear regressions of appendicular skeletal mass, adjusted for fat mass and height. Prevalence of sarcopenia in older (65 years and older people by these three methods for men was 2.5%, 6.2%, and 6.4% and for women 0.3%, 9.3%, and 8.5%, respectively. Conclusions. Sarcopenia is common but consensus on the best method to confirm low muscle mass is required.

  1. Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity.

    Directory of Open Access Journals (Sweden)

    Tingqing Guo

    Full Text Available Myostatin (Mstn is a secreted growth factor expressed in skeletal muscle and adipose tissue that negatively regulates skeletal muscle mass. Mstn(-/- mice have a dramatic increase in muscle mass, reduction in fat mass, and resistance to diet-induced and genetic obesity. To determine how Mstn deletion causes reduced adiposity and resistance to obesity, we analyzed substrate utilization and insulin sensitivity in Mstn(-/- mice fed a standard chow. Despite reduced lipid oxidation in skeletal muscle, Mstn(-/- mice had no change in the rate of whole body lipid oxidation. In contrast, Mstn(-/- mice had increased glucose utilization and insulin sensitivity as measured by indirect calorimetry, glucose and insulin tolerance tests, and hyperinsulinemic-euglycemic clamp. To determine whether these metabolic effects were due primarily to the loss of myostatin signaling in muscle or adipose tissue, we compared two transgenic mouse lines carrying a dominant negative activin IIB receptor expressed specifically in adipocytes or skeletal muscle. We found that inhibition of myostatin signaling in adipose tissue had no effect on body composition, weight gain, or glucose and insulin tolerance in mice fed a standard diet or a high-fat diet. In contrast, inhibition of myostatin signaling in skeletal muscle, like Mstn deletion, resulted in increased lean mass, decreased fat mass, improved glucose metabolism on standard and high-fat diets, and resistance to diet-induced obesity. Our results demonstrate that Mstn(-/- mice have an increase in insulin sensitivity and glucose uptake, and that the reduction in adipose tissue mass in Mstn(-/- mice is an indirect result of metabolic changes in skeletal muscle. These data suggest that increasing muscle mass by administration of myostatin antagonists may be a promising therapeutic target for treating patients with obesity or diabetes.

  2. Prevalence of skeletal muscle mass loss and its association with swallowing function after cardiovascular surgery.

    Science.gov (United States)

    Wakabayashi, Hidetaka; Takahashi, Rimiko; Watanabe, Naoko; Oritsu, Hideyuki; Shimizu, Yoshitaka

    2017-06-01

    The aim of this study was to assess the prevalence of skeletal muscle mass loss and its association with swallowing function in patients with dysphagia after cardiovascular surgery. A retrospective cohort study was performed in 65 consecutive patients with dysphagia after cardiovascular surgery who were prescribed speech therapy. Skeletal muscle index (SMI) was calculated as total psoas muscle area assessed via abdominal computed tomography divided by height squared. Cutoff values were 6.36 cm 2 /m 2 for men and 3.92 cm 2 /m 2 for women. The Food Intake Level Scale (FILS) was used to assess the swallowing function. Univariate and ordered logistic regression analyses were applied to examine the associations between skeletal muscle mass loss and dysphagia. The study included 50 men and 15 women (mean age 73 ± 8 y). The mean SMI was 4.72 ± 1.37 cm 2 /m 2 in men and 3.33 ± 1.42 cm 2 /m 2 in women. Skeletal muscle mass loss was found in 53 (82%) patients. Twelve had tracheostomy cannula. Thirteen were non-oral feeding (FILS levels 1-3), 5 were oral food intake and alternative nutrition (levels 4-6), and 47 were oral food intake alone (levels 7-9) at discharge. The FILS at discharge was significantly lower in patients with skeletal muscle mass loss. Ordered logistic regression analysis of swallowing function showed that skeletal muscle mass loss and tracheostomy cannula were associated independently with the FILS at discharge. The prevalence of skeletal muscle mass loss is very high, and skeletal muscle mass loss is associated with swallowing function. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Adiposity, muscle mass and muscle strength in relation to functional decline in older persons.

    NARCIS (Netherlands)

    Schaap, L.A.; Koster, A.; Visser, M.

    2013-01-01

    Aging is associated with changes in body composition and muscle strength. This review aimed to determine the relation between different body composition measures and muscle strength measures and functional decline in older men and women. By use of relevant databases (PubMed, Embase, and CINAHL) and

  4. CO{sub 2} ICE TOWARD LOW-LUMINOSITY EMBEDDED PROTOSTARS: EVIDENCE FOR EPISODIC MASS ACCRETION VIA CHEMICAL HISTORY

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyo Jeong; Evans, Neal J. II [Department of Astronomy, University of Texas at Austin, 2515 Speedway, Stop C1400 Austin, TX 78712-1205 (United States); Dunham, Michael M. [Department of Astronomy, Yale University, P.O. Box 208101, New Haven, CT 06520 (United States); Lee, Jeong-Eun [Department of Astronomy and Space Science, Kyung Hee University, Yongin-si, Gyeonggi-do 446-701 (Korea, Republic of); Pontoppidan, Klaus M., E-mail: hyojeong@astro.as.utexas.edu [Space Telescope Science Institute, Baltimore, MD 21218 (United States)

    2012-10-10

    We present Spitzer IRS spectroscopy of CO{sub 2} ice bending mode spectra at 15.2 {mu}m toward 19 young stellar objects (YSOs) with luminosity lower than 1 L{sub Sun} (3 with luminosity lower than 0.1 L{sub Sun }). Ice on dust grain surfaces can encode the history of heating because pure CO{sub 2} ice forms only at elevated temperature, T > 20 K, and thus around protostars of higher luminosity. Current internal luminosities of YSOs with L < 1L{sub Sun} do not provide the conditions needed to produce pure CO{sub 2} ice at radii where typical envelopes begin. The presence of detectable amounts of pure CO{sub 2} ice would signify a higher past luminosity. Many of the spectra require a contribution from a pure, crystalline CO{sub 2} component, traced by the presence of a characteristic band splitting in the 15.2 {mu}m bending mode. About half of the sources (9 out of 19) in the low-luminosity sample have evidence for pure CO{sub 2} ice, and 6 of these have significant double-peaked features, which are very strong evidence of pure CO{sub 2} ice. The presence of the pure CO{sub 2} ice component indicates that the dust temperature, and hence luminosity of the central star/accretion disk system, must have been higher in the past. An episodic accretion scenario, in which mixed CO-CO{sub 2} ice is converted to pure CO{sub 2} ice during each high-luminosity phase, explains the presence of pure CO{sub 2} ice, the total amount of CO{sub 2} ice, and the observed residual C{sup 18}O gas.

  5. Increasing Muscle Mass Improves Vascular Function in Obese (db/db) Mice

    Science.gov (United States)

    Qiu, Shuiqing; Mintz, James D.; Salet, Christina D.; Han, Weihong; Giannis, Athanassios; Chen, Feng; Yu, Yanfang; Su, Yunchao; Fulton, David J.; Stepp, David W.

    2014-01-01

    Background A sedentary lifestyle is an independent risk factor for cardiovascular disease and exercise has been shown to ameliorate this risk. Inactivity is associated with a loss of muscle mass, which is also reversed with isometric exercise training. The relationship between muscle mass and vascular function is poorly defined. The aims of the current study were to determine whether increasing muscle mass by genetic deletion of myostatin, a negative regulator of muscle growth, can influence vascular function in mesenteric arteries from obese db/db mice. Methods and Results Myostatin expression was elevated in skeletal muscle of obese mice and associated with reduced muscle mass (30% to 50%). Myostatin deletion increased muscle mass in lean (40% to 60%) and obese (80% to 115%) mice through increased muscle fiber size (PMyostatin deletion decreased adipose tissue in lean mice, but not obese mice. Markers of insulin resistance and glucose tolerance were improved in obese myostatin knockout mice. Obese mice demonstrated an impaired endothelial vasodilation, compared to lean mice. This impairment was improved by superoxide dismutase mimic Tempol. Deletion of myostatin improved endothelial vasodilation in mesenteric arteries in obese, but not in lean, mice. This improvement was blunted by nitric oxide (NO) synthase inhibitor l‐NG‐nitroarginine methyl ester (l‐NAME). Prostacyclin (PGI2)‐ and endothelium‐derived hyperpolarizing factor (EDHF)‐mediated vasodilation were preserved in obese mice and unaffected by myostatin deletion. Reactive oxygen species) was elevated in the mesenteric endothelium of obese mice and down‐regulated by deletion of myostatin in obese mice. Impaired vasodilation in obese mice was improved by NADPH oxidase inhibitor (GKT136901). Treatment with sepiapterin, which increases levels of tetrahydrobiopterin, improved vasodilation in obese mice, an improvement blocked by l‐NAME. Conclusions Increasing muscle mass by genetic deletion of

  6. The influence of different muscle mass measurements on the diagnosis of cancer cachexia.

    Science.gov (United States)

    Blauwhoff-Buskermolen, Susanne; Langius, Jacqueline A E; Becker, Annemarie; Verheul, Henk M W; de van der Schueren, Marian A E

    2017-08-01

    Progressive loss of muscle mass is a major characteristic of cancer cachexia. Consensus definitions for cachexia provide different options to measure muscle mass. This study describes the effect of different methods to determine muscle mass on the diagnosis of cancer cachexia. In addition, the association of cachexia with other features of cachexia, quality of life, and survival was explored. Prior to chemotherapy, cachexia was assessed by weight loss, body mass index, and muscle mass measurements, the latter by mid-upper arm muscle area (MUAMA), computed tomography (CT) scans, and bio-electrical impedance analysis (BIA). In addition, appetite, inflammation, muscle strength, fatigue, quality of life, and survival were measured, and associations with cachexia were explored. Included were 241 patients with advanced cancer of the lung (36%), colon/rectum (31%), prostate (18%), or breast (15%). Mean age was 64 ± 10 years; 54% was male. Prevalence of low muscle mass was as follows: 13% with MUAMA, 59% with CT, and 93% with BIA. In turn, the prevalence of cachexia was 37, 43, and 48%, whereby weight loss >5% was the most prominent component of being defined cachectic. Irrespective of type of muscle measurement, patients with cachexia presented more often with anorexia, inflammation, low muscle strength, and fatigue and had lower quality of life. Patients with cachexia had worse overall survival compared with patients without cachexia: HRs 2.00 (1.42-2.83) with MUAMA, 1.64 (1.15-2.34) with CT, and 1.50 (1.05-2.14) with BIA. Although the prevalence of low muscle mass in patients with cancer depended largely on the type of muscle measurement, this had little influence on the diagnosis of cancer cachexia (as the majority of patients was already defined cachectic based on weight loss). New studies are warranted to further elucidate the additional role of muscle measurements in the diagnosis of cachexia and the association with clinical outcomes. © 2017 The Authors

  7. Total body skeletal muscle mass: estimation by creatine (methyl-d3) dilution in humans

    Science.gov (United States)

    Walker, Ann C.; O'Connor-Semmes, Robin L.; Leonard, Michael S.; Miller, Ram R.; Stimpson, Stephen A.; Turner, Scott M.; Ravussin, Eric; Cefalu, William T.; Hellerstein, Marc K.; Evans, William J.

    2014-01-01

    Current methods for clinical estimation of total body skeletal muscle mass have significant limitations. We tested the hypothesis that creatine (methyl-d3) dilution (D3-creatine) measured by enrichment of urine D3-creatinine reveals total body creatine pool size, providing an accurate estimate of total body skeletal muscle mass. Healthy subjects with different muscle masses [n = 35: 20 men (19–30 yr, 70–84 yr), 15 postmenopausal women (51–62 yr, 70–84 yr)] were housed for 5 days. Optimal tracer dose was explored with single oral doses of 30, 60, or 100 mg D3-creatine given on day 1. Serial plasma samples were collected for D3-creatine pharmacokinetics. All urine was collected through day 5. Creatine and creatinine (deuterated and unlabeled) were measured by liquid chromatography mass spectrometry. Total body creatine pool size and muscle mass were calculated from D3-creatinine enrichment in urine. Muscle mass was also measured by magnetic resonance imaging (MRI), dual-energy x-ray absorptiometry (DXA), and traditional 24-h urine creatinine. D3-creatine was rapidly absorbed and cleared with variable urinary excretion. Isotopic steady-state of D3-creatinine enrichment in the urine was achieved by 30.7 ± 11.2 h. Mean steady-state enrichment in urine provided muscle mass estimates that correlated well with MRI estimates for all subjects (r = 0.868, P creatine dose determined by urine D3-creatinine enrichment provides an estimate of total body muscle mass strongly correlated with estimates from serial MRI with less bias than total lean body mass assessment by DXA. PMID:24764133

  8. Skeletal muscle mass and exercise performance in stable ambulatory patients with heart failure.

    Science.gov (United States)

    Lang, C C; Chomsky, D B; Rayos, G; Yeoh, T K; Wilson, J R

    1997-01-01

    The purpose of this study was to determine whether skeletal muscle atrophy limits the maximal exercise capacity of stable ambulatory patients with heart failure. Body composition and maximal exercise capacity were measured in 100 stable ambulatory patients with heart failure. Body composition was assessed by using dual-energy X-ray absorption. Peak exercise oxygen consumption (VO2peak) and the anaerobic threshold were measured by using a Naughton treadmill protocol and a Medical Graphics CardioO2 System. VO2peak averaged 13.4 +/- 3.3 ml.min-1.kg-1 or 43 +/- 12% of normal. Lean body mass averaged 52.9 +/- 10.5 kg and leg lean mass 16.5 +/- 3.6 kg. Leg lean mass correlated linearly with VO2peak (r = 0.68, P < 0.01), suggesting that exercise performance is influences by skeletal muscle mass. However, lean body mass was comparable to levels noted in 1,584 normal control subjects, suggesting no decrease in muscle mass. Leg muscle mass was comparable to levels noted in 34 normal control subjects, further supporting this conclusion. These findings suggest that exercise intolerance in stable ambulatory patients with heart failure is not due to skeletal muscle atrophy.

  9. The Effects of Muscle Mass on Homocyst(e)ine Levels in Plasma and Urine.

    Science.gov (United States)

    Malinow, M René; Lister, Craig L; DE Crée, Carl

    The present study was designed to examine the relationship between homocyst(e)ine (H[e]) levels and muscle mass. Two experimental groups each of 24 Caucasian males, one consisting of higher-muscle mass subjects (HMM) and the other of lower-muscle mass subjects (LMM) participated in this study. Muscle mass was estimated from 24-hour urine collections of creatinine (Crt). Muscle mass was 40.3 ± 15.9 kg in HMM and 37.2 ± 11.4 kg in LMM (P= 0.002). Mean plasma H(e) levels in HMM were 10.29 ± 2.9 nmol/mL, and in LMM were 10.02 ± 2.4 nmol/L (Not significant, [NS]). Urinary H(e) levels (UH[e]) were 9.95 ± 4.3 nmol/mL and 9.22 ± 2.9 nmol/mL for HMM and LMM, respectively (NS). Plasma H(e) levels correlated well with UH(e) (HMM: r= 0.58, P= 0.009; LMM: r= 0.66, P= 0.004). Muscle mass and was not correlated to either plasma H(e) or UH(e). However, in HMM trends were identified for body mass to be correlated with UH(e) (r= 0.39, P= 0.10) and UCrt (r= 0.41, P= 0.08). Surprisingly, in HMM plasma and UCrt were only weakly correlated (r= 0.44, P= 0.06). Our results do not support a causal relationship between the amount of muscle mass and H(e) levels in plasma or urine.

  10. Wind accretion: Theory and observations

    Science.gov (United States)

    Shakura, N. I.; Postnov, K. A.; Kochetkova, A. Yu.; Hjalmarsdotter, L.; Sidoli, L.; Paizis, A.

    2015-07-01

    A review of wind accretion in high-mass X-ray binaries is presented. We focus on different regimes of quasi-spherical accretion onto the neutron star (NS): the supersonic (Bondi) accretion, which takes place when the captured matter cools down rapidly and falls supersonically towards the NS magnetosphere, and subsonic (settling) accretion which occurs when plasma remains hot until it meets the magnetospheric boundary. These two regimes of accretion are separated by an X-ray luminosity of about 4 × 1036 erg s-1. In the subsonic case, which sets in at lower luminosities, a hot quasi-spherical shell must form around the magnetosphere, and the actual accretion rate onto NS is determined by the ability of the plasma to enter the magnetosphere due to Rayleigh-Taylor instability. In turn, two regimes of subsonic accretion are possible, depending on plasma cooling mechanism (Compton or radiative) near the magnetopshere. The transition from the high-luminosity with Compton cooling to the lowluminosity (Lx ≲ 3 × 1035 erg s-1) with radiative cooling can be responsible for the onset of the off states repeatedly observed in several low-luminosity slowly accreting pulsars, such as Vela X-1, GX 301-2, and 4U 1907+09. The triggering of the transitionmay be due to a switch in the X-ray beam pattern in response to a change in the optical depth in the accretion column with changing luminosity. We also show that in the settling accretion theory, bright X-ray flares (~1038-1040 erg) observed in supergiant fast X-ray transients (SFXT) can be produced by sporadic capture of magnetized stellar wind plasma. At sufficiently low accretion rates, magnetic reconnection can enhance the magnetospheric plasma entry rate, resulting in copious production of X-ray photons, strong Compton cooling and ultimately in unstable accretion of the entire shell. A bright flare develops on the free-fall time scale in the shell, and the typical energy released in an SFXT bright flare corresponds to the mass

  11. The impact of low muscle mass definition on the prevalence of sarcopenia in older Australians.

    Science.gov (United States)

    Yu, Solomon; Appleton, Sarah; Adams, Robert; Chapman, Ian; Wittert, Gary; Visvanathan, Thavarajah; Visvanathan, Renuka

    2014-01-01

    Sarcopenia is the presence of low muscle mass and low muscle function. The aim of this study was to establish cutoffs for low muscle mass using three published methods and to compare the prevalence of sarcopenia in older Australians. Gender specific cutoffs levels were identified for low muscle mass using three different methods. Low grip strength was determined using established cutoffs of standard deviation (SD) of a young reference population; (b) <7.36 kg/m(2) for men and <5.81 kg/m(2) for women from the lowest 20% percentile of the older group; and (c) <-2.15 for men and <-1.42 for women from the lowest 20% of the residuals of linear regressions of appendicular skeletal mass, adjusted for fat mass and height. Prevalence of sarcopenia in older (65 years and older) people by these three methods for men was 2.5%, 6.2%, and 6.4% and for women 0.3%, 9.3%, and 8.5%, respectively. Sarcopenia is common but consensus on the best method to confirm low muscle mass is required.

  12. Mechanistic Links Underlying the Impact of C-Reactive Protein on Muscle Mass in Elderly

    Directory of Open Access Journals (Sweden)

    Britta Wåhlin-Larsson

    2017-11-01

    Full Text Available Background/Aims: Mechanisms underlying the relationship between systemic inflammation and age-related decline in muscle mass are poorly defined. The purpose of this work was to investigate the relationship between the systemic inflammatory marker CRP and muscle mass in elderly and to identify mechanisms by which CRP mediates its effects on skeletal muscle, in-vitro. Methods: Muscle mass and serum CRP level were determined in a cohort of 118 older women (67±1.7 years. Human muscle cells were differentiated into myotubes and were exposed to CRP. The size of myotubes was determined after immunofluorescent staining using troponin. Muscle protein synthesis was assessed using stable isotope tracers and key signalling pathways controlling protein synthesis were determined using western-blotting. Results: We observed an inverse relationship between circulating CRP level and muscle mass (β= -0.646 (95% CI: -0.888, -0.405 p<0.05 and demonstrated a reduction (p < 0.05 in the size of human myotubes exposed to CRP for 72 h. We next showed that this morphological change was accompanied by a CRP-mediated reduction (p < 0.05 in muscle protein fractional synthetic rate of human myotubes exposed to CRP for 24 h. We also identified a CRP-mediated increased phosphorylation (p<0.05 of regulators of cellular energy stress including AMPK and downstream targets, raptor and ACC-β, together with decreased phosphorylation of Akt and rpS6, which are important factors controlling protein synthesis. Conclusion: This work established for the first time mechanistic links by which chronic elevation of CRP can contribute to age-related decline in muscle function.

  13. Locomotion and muscle mass measures in a murine model of collagen-induced arthritis

    NARCIS (Netherlands)

    Hartog, A.; Hulsman, J.; Garssen, J.

    2009-01-01

    Background: Rheumatoid arthritis (RA) is characterized by chronic poly-arthritis, synovial hyperplasia, erosive synovitis, progressive cartilage and bone destruction accompanied by a loss of body cell mass. This loss of cell mass, known as rheumatoid cachexia, predominates in the skeletal muscle and

  14. Peak muscle mass in young men and sarcopenia in the ageing male

    DEFF Research Database (Denmark)

    Nielsen, Morten Frost Munk; Nielsen, T L; Brixen, K

    2015-01-01

    of sarcopenia in men. INTRODUCTION: The ageing population increases the prevalence of sarcopenia. Estimation of normative data on muscle mass in young men during the peak of anabolic hormones is necessary for the diagnosis of sarcopenia in ageing males. The purposes of this study were to provide population......The prevalence of sarcopenia increases with age. The diagnosis of sarcopenia relies in part on normative data on muscle mass, but these data are lacking. This study provides population-based reference data on muscle mass in young men, and these results may be used clinically for the diagnosis......-based reference data on lean body mass (LBM) in young men during the time of peak levels of GH/IGF-1 and testosterone and further to apply the reference data on a population-based sample of men aged 60-74 years to estimate the prevalence of sarcopenia. METHODS: This is a cross-sectional, population-based single...

  15. Growth hormone mitigates loss of periosteal bone formation and muscle mass in disuse osteopenic rats.

    Science.gov (United States)

    Grubbe, M-C; Thomsen, J S; Nyengaard, J R; Duruox, M; Brüel, A

    2014-12-01

    Growth hormone (GH) is a potent anabolic agent capable of increasing both bone and muscle mass. The aim was to investigate whether GH could counteract disuse-induced loss of bone and muscle mass in a rat model. Paralysis was induced by injecting 4 IU Botox (BTX) into the muscles of the right hind limb. Sixty female Wistar rats, 14 weeks old, were divided into the following groups: baseline, controls, BTX, BTX+GH, and GH. GH was given at a dosage of 5 mg/kg/d for 4 weeks. Compared with controls, BTX resulted in lower periosteal bone formation rate (BFR/BS,-79%, Pbone mineral density (aBMD, -13%, Pbone volume (BV/TV, -26%, Pbone strength (-12%, Pbone strength was found. In addition, GH partly prevented loss of muscle mass (+29% vs. BTX, P<0.001), and tended to prevent loss of muscle CSA (+11%, P=0.064). In conclusion, GH mitigates disuse-induced loss of periosteal BFR/BS at the mid-femur and rectus femoris muscle mass.

  16. Ultrasonography to Measure Swallowing Muscle Mass and Quality in Older Patients With Sarcopenic Dysphagia.

    Science.gov (United States)

    Ogawa, Nami; Mori, Takashi; Fujishima, Ichiro; Wakabayashi, Hidetaka; Itoda, Masataka; Kunieda, Kenjiro; Shigematsu, Takashi; Nishioka, Shinta; Tohara, Haruka; Yamada, Minoru; Ogawa, Sumito

    2018-06-01

    Sarcopenic dysphagia is characterized by difficulty swallowing due to a loss of whole-body skeletal and swallowing muscle mass and function. However, no study has reported on swallowing muscle mass and quality in patients with sarcopenic dysphagia. To compare the differences in swallowing muscle mass and quality between sarcopenic and nonsarcopenic dysphagia. A cross-sectional study was performed in 55 older patients, who had been recommended to undergo dysphagia assessment and/or rehabilitation. Sarcopenic dysphagia was diagnosed using a diagnostic algorithm for sarcopenic dysphagia. The thickness and area of tongue muscle and geniohyoid muscle (coronal plane and sagittal plane), and the echo-intensity of the tongue and geniohyoid muscles were examined by ultrasound. The study participants included 31 males and 24 females (mean age of 82 ± 7 years), with 14 having possible sarcopenic dysphagia, 22 probable sarcopenic dysphagia, and 19 without sarcopenic dysphagia. The group with sarcopenic dysphagia had a significantly lower cross-sectional area and area of brightness of the tongue muscle than that observed in the group without sarcopenic dysphagia. The most specific factor for identifying the presence of sarcopenic dysphagia was tongue muscle area (sensitivity, 0.389; specificity, 0.947; cut-off value, 1536.0), while the factor with the highest sensitivity was geniohyoid muscle area brightness in sagittal sections (sensitivity, 0.806; specificity, 0.632; cut-off value, 20.1). Multivariate logistic regression analysis showed that the area of the tongue muscle and its area of brightness were independent risk factors for sarcopenic dysphagia. However, geniohyoid sagittal muscle area and area of brightness showed no significant independent association with sarcopenic dysphagia. Tongue muscle mass in patients with sarcopenic dysphagia was smaller than that in patients without the condition. Sarcopenic dysphagia was also associated with increased intensity of the

  17. Tinetti mobility test is related to muscle mass and strength in non-institutionalized elderly people.

    Science.gov (United States)

    Curcio, Francesco; Basile, Claudia; Liguori, Ilaria; Della-Morte, David; Gargiulo, Gaetano; Galizia, Gianluigi; Testa, Gianluca; Langellotto, Assunta; Cacciatore, Francesco; Bonaduce, Domenico; Abete, Pasquale

    2016-12-01

    Elderly people are characterized by a high prevalence of falls and sarcopenia. However, the relationship among Tinetti mobility test (TMT) score, a powerful tool to detect elderly people at risk of falls, and sarcopenia is still not thoroughly investigated. Thus, to determine the relationship between TMT score and muscle mass and strength, 337 elderly participants (mean age 77.1 ± 6.9 years) admitted to comprehensive geriatric assessment were enrolled. TMT score, muscle mass by bioimpedentiometer, and muscle strength by grip strength were evaluated. Muscle mass progressively decreased as TMT score decreased (from 15.3 ± 3.7 to 8.8 ± 1.8 kg/m 2 ; p for trend strength decreased progressively as Tinetti score decreased (from 34.7 ± 8.0 to 23.7 ± 8.7 kg; p for trend 0.001). Linear regression analysis demonstrated that TMT score is linearly related with muscle mass (y = 4.5x + 0.4, r = 0.61; p strength (y = 14.0x + 0.8, r = 0.53; p strength (r = 0.39, p = 0.046). The present study indicates that TMT score is significantly related to muscle mass and strength in non-institutionalized elderly participants. This evidence suggests that TMT score, together with evaluation of muscle mass and strength, may identify sarcopenic elderly participants at high risk of falls.

  18. Effect of anabolic steroids on skeletal muscle mass during hindlimb suspension

    Science.gov (United States)

    Tsika, R. W.; Herrick, R. E.; Baldwin, K. M.

    1987-01-01

    The effect of treatment with an anabolic steroid (nandrolone decanoate) on the muscle mass of plantaris and soleus of a rats in hindlimb suspension, and on the isomyosin expression in these muscles, was investigated in young female rats divided into four groups: normal control (NC), normal steroid (NS), normal suspension (N-sus), and suspension steroid (sus-S). Steroid treatment of suspended animals (sus-S vs N-sus) was found to partially spare body weight and muscle weight, as well as myofibril content of plantaris (but not soleus), but did not modify the isomyosin pattern induced by suspension. In normal rats (NS vs NC), steroid treatment did enhance body weight and plantaris muscle weight; the treatment did not alter isomyosin expression in either muscle type.

  19. Low muscle mass--tall and obese children a special genre of obesity.

    Science.gov (United States)

    Ralt, Dina

    2007-01-01

    The prevalence of over-weight and obesity has increased markedly in the last two decades and vast international resources have been directed toward researching these issues. Obesity would appear to be a problem that is easy to resolve: just eat less and move more. However, this very common condition has turned out to be extremely troublesome, and in some cases even insolvable. A perspective is presented here suggesting that some of the insoluble cases of obesity are the result of an inborn condition of a very low muscle mass. The interplay between less muscle and more fat tissue is discussed from physiological and environmental perspectives with an emphasis on the early years of childhood. It is proposed that these interactions lead to bodily economic decisions sliding between thrift or prodigal strategies. The thrift strategy results not only in obesity and less physical activity but also in other maladies which the body is unable to manage. What leads to obesity (less muscle, more fat) in the medial population will result in morbid obesity when the children are short of muscle tissue from the start. Attempts to lessen the consequences of low muscle mass, which might be very difficult at adulthood, can be more fruitful if initiated at childhood. Early recognition of the ailment is thus crucial. Based on studies demonstrating a 'rivalry' between muscle build-up and height growth at childhood, it is postulated that among the both taller and more obese children the percentage of children with lower muscle mass will be significant. A survey of the height and BMI (Body Mass Index) of Israeli fifth graders supports this postulation. A special, body/muscle-building gymnastics program for children is suggested as a potential early intervention to partially prevent this type of almost irreversible ill progress of obesity.

  20. Delayed Recovery of Skeletal Muscle Mass following Hindlimb Immobilization in mTOR Heterozygous Mice

    OpenAIRE

    Lang, Susan M.; Kazi, Abid A.; Hong-Brown, Ly; Lang, Charles H.

    2012-01-01

    The present study addressed the hypothesis that reducing mTOR, as seen in mTOR heterozygous (+/-) mice, would exaggerate the changes in protein synthesis and degradation observed during hindlimb immobilization as well as impair normal muscle regrowth during the recovery period. Atrophy was produced by unilateral hindlimb immobilization and data compared to the contralateral gastrocnemius. In wild-type (WT) mice, the gradual loss of muscle mass plateaued by day 7. This response was associated ...

  1. Impaired physical function, loss of muscle mass and assessment of biomechanical properties in critical ill patients

    DEFF Research Database (Denmark)

    Poulsen, Jesper Brøndum

    2012-01-01

    Intensive care unit (ICU) admission is associated with muscle weakness and ICU survivors report sustained limitation of physical capacity for years after discharge. Limited information is available on the underlying biomechanical properties responsible for this muscle function impairment. A plaus......Intensive care unit (ICU) admission is associated with muscle weakness and ICU survivors report sustained limitation of physical capacity for years after discharge. Limited information is available on the underlying biomechanical properties responsible for this muscle function impairment....... A plausible contributor to the accentuated catabolic drive in ICU patients is a synergistic response to inflammation and inactivity leading to loss of muscle mass. As these entities are predominantly present in the early phase of ICU stay, interventions employed during this time frame may exhibit the greatest...... potential to counteract loss of muscle mass. Despite the obvious clinical significance of muscle atrophy for the functional impairment observed in ICU survivors, no preventive therapies have been identified as yet. The overall aim of the present dissertation is to characterize aspects of physical function...

  2. The loss of skeletal muscle strength, mass, and quality in older adults : the health, aging and body composition study

    NARCIS (Netherlands)

    Goodpaster, Bret H; Park, Seok Won; Harris, Tamara B; Kritchevsky, Steven B; Nevitt, Michael; Schwartz, Ann V; Simonsick, Eleanor M; Tylavsky, Frances A; Visser, Marjolein; Newman, Anne B

    2006-01-01

    BACKGROUND: The loss of muscle mass is considered to be a major determinant of strength loss in aging. However, large-scale longitudinal studies examining the association between the loss of mass and strength in older adults are lacking. METHODS: Three-year changes in muscle mass and strength were

  3. Creatinine excretion rate, a marker of muscle mass, is related to clinical outcome in patients with chronic systolic heart failure

    NARCIS (Netherlands)

    ter Maaten, Jozine M.; Damman, Kevin; Hillege, Hans L.; Bakker, Stephan J.; Anker, Stefan D.; Navis, Gerjan; Voors, Adriaan A.

    2014-01-01

    Aims In chronic heart failure (CHF), low body mass as a reflection of low muscle mass has been associated with poor outcome. Urinary creatinine excretion rate (CER) is an established marker of muscle mass, but has not been investigated in CHF. This study aims to evaluate urinary CER as a marker of

  4. Relative Skeletal Muscle Mass Is Associated with Development of Metabolic Syndrome

    Directory of Open Access Journals (Sweden)

    Byung Sam Park

    2013-12-01

    Full Text Available BackgroundVisceral adiposity is related to insulin resistance. Skeletal muscle plays a central role in insulin-mediated glucose disposal; however, little is known about the association between muscle mass and metabolic syndrome (MS. This study is to clarify the clinical role of skeletal muscle mass in development of MS.MethodsA total of 1,042 subjects were enrolled. Subjects with prior MS and chronic diseases were excluded. After 24 months, development of MS was assessed using NCEP-ATP III criteria. Skeletal muscle mass (SMM; kg, body fat mass (BFM; kg, and visceral fat area (VFA; cm2 were obtained from bioelectrical analysis. Then, the following values were calculated as follows: percent of SMM (SMM%; %: SMM (kg/weight (kg, skeletal muscle index (SMI; kg/m2: SMM (kg/height (m2, skeletal muscle to body fat ratio (MFR: SMM (kg/BFM (kg, and skeletal muscle to visceral fat ratio (SVR; kg/cm2: SMM (kg/VFA (cm2.ResultsAmong 838 subjects, 88 (10.5% were newly diagnosed with MS. Development of MS increased according to increasing quintiles of BMI, SMM, VFA, and SMI, but was negatively associated with SMM%, MFR, and SVR. VFA was positively associated with high waist circumference (WC, high blood pressure (BP, dysglycemia, and high triglyceride (TG. In contrast, MFR was negatively associated with high WC, high BP, dysglycemia, and high TG. SVR was negatively associated with all components of MS.ConclusionRelative SMM ratio to body composition, rather than absolute mass, may play a critical role in development of MS and could be used as a strong predictor.

  5. Muscle mass as a target to reduce fatigue in patients with advanced cancer.

    Science.gov (United States)

    Neefjes, Elisabeth C W; van den Hurk, Renske M; Blauwhoff-Buskermolen, Susanne; van der Vorst, Maurice J D L; Becker-Commissaris, Annemarie; de van der Schueren, Marian A E; Buffart, Laurien M; Verheul, Henk M W

    2017-08-01

    Cancer-related fatigue (CRF) reduces quality of life and the activity level of patients with cancer. Cancer related fatigue can be reduced by exercise interventions that may concurrently increase muscle mass. We hypothesized that low muscle mass is directly related to higher CRF. A total of 233 patients with advanced cancer starting palliative chemotherapy for lung, colorectal, breast, or prostate cancer were studied. The skeletal muscle index (SMI) was calculated as the patient's muscle mass on level L3 or T4 of a computed tomography scan, adjusted for height. Fatigue was assessed with the Functional Assessment of Chronic Illness Therapy-fatigue questionnaire (cut-off for fatigue fatigue score was 36 (interquartile range 26-44). A higher SMI on level L3 was significantly associated with less CRF for men (B 0.447, P 0.004) but not for women (B - 0.401, P 0.090). No association between SMI on level T4 and the Functional Assessment of Chronic Illness Therapy-fatigue score was found (n = 82). The association between SMI and CRF may lead to the suggestion that male patients may be able to reduce fatigue by exercise interventions aiming at an increased muscle mass. In women with advanced cancer, CRF is more influenced by other causes, because it is not significantly related to muscle mass. To further reduce CRF in both men and women with cancer, multifactorial assessments need to be performed in order to develop effective treatment strategies. © 2017 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders.

  6. Correlates of increased lean muscle mass in women with polycystic ovary syndrome.

    Science.gov (United States)

    Carmina, E; Guastella, E; Longo, R A; Rini, G B; Lobo, R A

    2009-10-01

    Muscle mass plays an important role in determining cardiovascular and metabolic risks in polycystic ovary syndrome (PCOS). In addition, whether lean mass influences carotid intima-media thickness (IMT) in PCOS has not been assessed. Prospective investigation. Ninety-five women with PCOS were age- and weight-matched to 90 ovulatory controls. All women had dual X-ray absorptiometry for lean, fat and bone mass, and bone mass density (BMD). Serum testosterone, sex hormone-binding globulin, insulin, and glucose and carotid IMT were determined. Free androgen index (FAI) and insulin resistance (by QUICKI) were calculated. In PCOS, waist circumference and insulin were higher and QUICKI lower than in controls (Plean mass were higher in PCOS compared to controls (PPCOS (PPCOS patients had abnormal (> or = 0.9 mm) values. Lean mass correlated with fat parameters, insulin, QUICKI, and FAI, but not with total testosterone; and after adjustments for insulin and QUICKI, lean mass still correlated with fat mass (PLean mass correlated with IMT (Plean mass independently of insulin. Bone mass correlated with lean and fat mass, but not with insulin or androgen. PCOS patients with 'pathological' IMT values had higher % trunk fat, lean mass, and insulin, lower QUICKI, and higher testosterone and FAI compared with those with normal IMT. Lean mass is increased in PCOS, while bone mass is similar to that of matched controls. The major correlates of lean mass are fat mass and insulin but not androgen. Lean mass also correlated with IMT, and although influenced by insulin, small changes in IMT may partially reflect changes in muscle mass, while clearly abnormal values relate to more severe abnormalities of PCOS.

  7. Within-Winter Flexibility in Muscle Masses, Myostatin, and Cellular Aerobic Metabolic Intensity in Passerine Birds.

    Science.gov (United States)

    Swanson, David L; King, Marisa O; Culver, William; Zhang, Yufeng

    Metabolic rates of passerine birds are flexible traits that vary both seasonally and among and within winters. Seasonal variation in summit metabolic rates (M sum = maximum thermoregulatory metabolism) in birds is consistently correlated with changes in pectoralis muscle and heart masses and sometimes with variation in cellular aerobic metabolic intensity, so these traits might also be associated with shorter-term, within-winter variation in metabolic rates. To determine whether these mechanisms are associated with within-winter variation in M sum , we examined the effects of short-term (ST; 0-7 d), medium-term (MT; 14-30 d), and long-term (LT; 30-yr means) temperature variables on pectoralis muscle and heart masses, pectoralis expression of the muscle-growth inhibitor myostatin and its metalloproteinase activators TLL-1 and TLL-2, and pectoralis and heart citrate synthase (CS; an indicator of cellular aerobic metabolic intensity) activities for two temperate-zone resident passerines, house sparrows (Passer domesticus) and dark-eyed juncos (Junco hyemalis). For both species, pectoralis mass residuals were positively correlated with ST temperature variables, suggesting that cold temperatures resulted in increased turnover of pectoralis muscle, but heart mass showed little within-winter variation for either species. Pectoralis mRNA and protein expression of myostatin and the TLLs were only weakly correlated with ST and MT temperature variables, which is largely consistent with trends in muscle masses for both species. Pectoralis and heart CS activities showed weak and variable trends with ST temperature variables in both species, suggesting only minor effects of temperature variation on cellular aerobic metabolic intensity. Thus, neither muscle or heart masses, regulation by the myostatin system, nor cellular aerobic metabolic intensity varied consistently with winter temperature, suggesting that other factors regulate within-winter metabolic variation in these birds.

  8. Artistic versus rhythmic gymnastics: effects on bone and muscle mass in young girls.

    Science.gov (United States)

    Vicente-Rodriguez, G; Dorado, C; Ara, I; Perez-Gomez, J; Olmedillas, H; Delgado-Guerra, S; Calbet, J A L

    2007-05-01

    We compared 35 prepubertal girls, 9 artistic gymnasts and 13 rhythmic gymnasts with 13 nonphysically active controls to study the effect of gymnastics on bone and muscle mass. Lean mass, bone mineral content and areal density were measured by dual energy X-ray absorptiometry, and physical fitness was also assessed. The artistic gymnasts showed a delay in pubertal development compared to the other groups (partistic gymnasts had a 16 and 17 % higher aerobic power and anaerobic capacity, while the rhythmic group had a 14 % higher anaerobic capacity than the controls, respectively (all partistic gymnasts had higher lean mass (partistic and the rhythmic gymnasts (partistic group compared to the other groups. Lean mass strongly correlated with bone mineral content (r=0.84, partistic gymnastic participation is associated with delayed pubertal development, enhanced physical fitness, muscle mass, and bone density in prepubertal girls, eliciting a higher osteogenic stimulus than rhythmic gymnastic.

  9. Psoas Muscle Cross-sectional Area as a Measure of Whole-body Lean Muscle Mass in Maintenance Hemodialysis Patients.

    Science.gov (United States)

    Morrell, Glen R; Ikizler, Talat A; Chen, Xiaorui; Heilbrun, Marta E; Wei, Guo; Boucher, Robert; Beddhu, Srinivasan

    2016-07-01

    We investigate whether psoas or paraspinous muscle area measured on a single L4-L5 image is a useful measure of whole lean body mass (LBM) compared to dedicated midthigh magnetic resonance imaging (MRI). Observational study. Outpatient dialysis units and a research clinic. One hundred five adult participants on maintenance hemodialysis. No control group was used. Psoas muscle area, paraspinous muscle area, and midthigh muscle area (MTMA) were measured by magnetic resonance imaging. LBM was measured by dual-energy absorptiometry scan. In separate multivariable linear regression models, psoas, paraspinous, and MTMA were associated with increase in LBM. In separate multivariate logistic regression models, C statistics for diagnosis of sarcopenia (defined as <25th percentile of LBM) were 0.69 for paraspinous muscle area, 0.81 for psoas muscle area, and 0.89 for MTMA. With sarcopenia defined as <10th percentile of LBM, the corresponding C statistics were 0.71, 0.92, and 0.94. We conclude that psoas muscle area provides a good measure of whole-body muscle mass, better than paraspinous muscle area but slightly inferior to midthigh measurement. Hence, in body composition studies a single axial MR image at the L4-L5 level can be used to provide information on both fat and muscle and may eliminate the need for time-consuming measurement of muscle area in the thigh. Copyright © 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  10. Accretion onto CO White Dwarfs using MESA

    Science.gov (United States)

    Feng, Wanda; Starrfield, Sumner

    2018-06-01

    The nature of type Ia Supernovae (SNe Ia) progenitor systems and their underlying mechanism are not well understood. There are two competing progenitor scenarios: the single-degenerate scenario wherein a white dwarf (WD) star accretes material from a companion star, reaching the Chandrasekhar mass limit; and, the double-degenerate scenario wherein two WDs merge. In this study, we investigate the single-degenerate scenario by accretion onto carbon-oxygen (CO) WDs using the Modules for Experiments in Stellar Astrophysics (MESA). We vary the WD mass, composition of the accreting material, and accretion rate in our models. Mixing between the accreted material and the WD core is informed by multidimensional studies that suggest occurance after thermonuclear runaway (TNR) ensues. We compare the accretion of solar composition material onto CO WDs with the accretion of mixed solar and core material after TNR. As many of our models eject less material than accreted, our study supports that accretion onto CO WDs is a feasible channel for SNe I progenitors.

  11. Strain in shock-loaded skeletal muscle and the time scale of muscular wobbling mass dynamics.

    Science.gov (United States)

    Christensen, Kasper B; Günther, Michael; Schmitt, Syn; Siebert, Tobias

    2017-10-16

    In terrestrial locomotion, muscles undergo damped oscillations in response to limb impacts with the ground. Muscles are also actuators that generate mechanical power to allow locomotion. The corresponding elementary contractile process is the work stroke of an actin-myosin cross-bridge, which may be forcibly detached by superposed oscillations. By experimentally emulating rat leg impacts, we found that full activity and non-fatigue must meet to possibly prevent forcible cross-bridge detachment. Because submaximal muscle force represents the ordinary locomotor condition, our results show that forcible, eccentric cross-bridge detachment is a common, physiological process even during isometric muscle contractions. We also calculated the stiffnesses of the whole muscle-tendon complex and the fibre material separately, as well as Young's modulus of the latter: 1.8 MPa and 0.75 MPa for fresh, fully active and passive fibres, respectively. Our inferred Young's modulus of the tendon-aponeurosis complex suggests that stiffness in series to the fibre material is determined by the elastic properties of the aponeurosis region, rather than the tendon material. Knowing these stiffnesses and the muscle mass, the complex' eigenfrequency for responses to impacts can be quantified, as well as the size-dependency of this time scale of muscular wobbling mass dynamics.

  12. Photometric Determination of the Mass Accretion Rates of Pre-main-sequence Stars. V. Recent Star Formation in the 30 Dor Nebula

    Science.gov (United States)

    De Marchi, Guido; Panagia, Nino; Beccari, Giacomo

    2017-09-01

    We report on the properties of the low-mass stars that recently formed in the central ˜ 2\\buildrel{ \\prime}\\over{.} 7× 2\\buildrel{ \\prime}\\over{.} 7 of 30 Dor, including the R136 cluster. Using the photometric catalog of De Marchi et al., based on observations with the Hubble Space Telescope, and the most recent extinction law for this field, we identify 1035 bona fide pre-main-sequence (PMS) stars showing {{H}}α excess emission at the 4σ level with an {{H}}α equivalent width of 20 Å or more. We find a wide spread in age spanning the range ˜ 0.1{--}50 {Myr}. We also find that the older PMS objects are placed in front of the R136 cluster and are separated from it by a conspicuous amount of absorbing material, indicating that star formation has proceeded from the periphery into the interior of the region. We derive physical parameters for all PMS stars, including masses m, ages t, and mass accretion rates {\\dot{M}}{acc}. To identify reliable correlations between these parameters, which are intertwined, we use a multivariate linear regression fit of the type {log}{\\dot{M}}{acc}=a× {log}t+b× {log}m+c. The values of a and b for 30 Dor are compatible with those found in NGC 346 and NGC 602. We extend the fit to a uniform sample of 1307 PMS stars with 0.5contract NAS5-26555.

  13. Role of Protein Carbonylation in Skeletal Muscle Mass Loss Associated with Chronic Conditions

    Directory of Open Access Journals (Sweden)

    Esther Barreiro

    2016-05-01

    Full Text Available Muscle dysfunction, characterized by a reductive remodeling of muscle fibers, is a common systemic manifestation in highly prevalent conditions such as chronic heart failure (CHF, chronic obstructive pulmonary disease (COPD, cancer cachexia, and critically ill patients. Skeletal muscle dysfunction and impaired muscle mass may predict morbidity and mortality in patients with chronic diseases, regardless of the underlying condition. High levels of oxidants may alter function and structure of key cellular molecules such as proteins, DNA, and lipids, leading to cellular injury and death. Protein oxidation including protein carbonylation was demonstrated to modify enzyme activity and DNA binding of transcription factors, while also rendering proteins more prone to proteolytic degradation. Given the relevance of protein oxidation in the pathophysiology of many chronic conditions and their comorbidities, the current review focuses on the analysis of different studies in which the biological and clinical significance of the modifications induced by reactive carbonyls on proteins have been explored so far in skeletal muscles of patients and animal models of chronic conditions such as COPD, disuse muscle atrophy, cancer cachexia, sepsis, and physiological aging. Future research will elucidate the specific impact and sites of reactive carbonyls on muscle protein content and function in human conditions.

  14. Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice.

    Science.gov (United States)

    Camporez, João-Paulo G; Petersen, Max C; Abudukadier, Abulizi; Moreira, Gabriela V; Jurczak, Michael J; Friedman, Glenn; Haqq, Christopher M; Petersen, Kitt Falk; Shulman, Gerald I

    2016-02-23

    Sarcopenia, or skeletal muscle atrophy, is a debilitating comorbidity of many physiological and pathophysiological processes, including normal aging. There are no approved therapies for sarcopenia, but the antihypertrophic myokine myostatin is a potential therapeutic target. Here, we show that treatment of young and old mice with an anti-myostatin antibody (ATA 842) for 4 wk increased muscle mass and muscle strength in both groups. Furthermore, ATA 842 treatment also increased insulin-stimulated whole body glucose metabolism in old mice, which could be attributed to increased insulin-stimulated skeletal muscle glucose uptake as measured by a hyperinsulinemic-euglycemic clamp. Taken together, these studies provide support for pharmacological inhibition of myostatin as a potential therapeutic approach for age-related sarcopenia and metabolic disease.

  15. Leg blood flow is impaired during small muscle mass exercise in patients with COPD

    DEFF Research Database (Denmark)

    Iepsen, Ulrik Winning; Munch, Gregers Druedal Wibe; Rugbjerg, Mette

    2017-01-01

    to both endothelium-independent (SNP) and endothelium-dependent (ACh) stimulation. The results suggests that leg muscle blood flow is impaired during small muscle mass exercise in patients with COPD possibly due to impaired formation of prostacyclin and increased levels of endothelin-1.......Skeletal muscle blood flow is regulated to match the oxygen demand and dysregulation could contribute to exercise intolerance in patients with COPD. We measured leg hemodynamics and metabolites from vasoactive compounds in muscle interstitial fluid and plasma at rest, during one-legged knee...... the formation of interstitial prostacyclin (vasodilator) was only increased in the controls. There was no difference between groups in the nitrite/nitrate levels (vasodilator) in plasma or interstitial fluid during exercise. Moreover, patients and controls showed similar vasodilatory capacity in response...

  16. Protostellar accretion traced with chemistry

    DEFF Research Database (Denmark)

    Frimann, Søren; Jørgensen, Jes Kristian; Dunham, Michael M.

    2017-01-01

    . Our aim is to characterise protostellar accretion histories towards individual sources by utilising sublimation and freeze-out chemistry of CO. Methods. A sample of 24 embedded protostars are observed with the Submillimeter Array (SMA) in context of the large program "Mass Assembly of Stellar Systems...

  17. Tissue Selective Androgen Receptor Modulators (SARMs) Increase Pelvic Floor Muscle Mass in Ovariectomized Mice.

    Science.gov (United States)

    Ponnusamy, Suriyan; Sullivan, Ryan D; Thiyagarajan, Thirumagal; Tillmann, Heather; Getzenberg, Robert H; Narayanan, Ramesh

    2017-03-01

    Stress urinary incontinence (SUI), a prevalent condition, is represented by an involuntary leakage of urine that results, at least in part, from weakened or damaged pelvic floor muscles and is triggered by physical stress. Current treatment options are limited with no oral therapies available. The pelvic floor is rich in androgen receptor and molecules with anabolic activity including selective androgen receptor modulators (SARMs) may serve as therapeutic options for individuals with SUI. In this study, two SARMs (GTx-024 and GTx-027) were evaluated in a post-menopausal animal model in order to determine their effect on pelvic floor muscles. Female C57BL/6 mice were ovariectomized and their pelvic muscles allowed to regress. The animals were then treated with vehicle or doses of GTx-024 or GTx-027. Animal total body weight, lean body mass, and pelvic floor muscle weights were measured along with the expression of genes associated with muscle catabolism. Treatment with the SARMs resulted in a restoration of the pelvic muscles to the sham-operated weight. Coordinately, the induction of genes associated with muscle catabolism was inhibited. Although a trend was observed towards an increase in total lean body mass in the SARM-treated groups, no significant differences were detected. Treatment of an ovariectomized mouse model with SARMs resulted in an increase in pelvic floor muscles, which may translate to an improvement of symptoms associated with SUI and serves as the basis for evaluating their clinical use. J. Cell. Biochem. 118: 640-646, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  18. Insulin Resistance Negatively Influences the Muscle-Dependent IGF-1-Bone Mass Relationship in Premenarcheal Girls.

    Science.gov (United States)

    Kindler, J M; Pollock, N K; Laing, E M; Jenkins, N T; Oshri, A; Isales, C; Hamrick, M; Lewis, R D

    2016-01-01

    IGF-1 promotes bone growth directly and indirectly through its effects on skeletal muscle. Insulin and IGF-1 share a common cellular signaling process; thus, insulin resistance may influence the IGF-1-muscle-bone relationship. We sought to determine the effect of insulin resistance on the muscle-dependent relationship between IGF-1 and bone mass in premenarcheal girls. This was a cross-sectional study conducted at a university research center involving 147 girls ages 9 to 11 years. Glucose, insulin, and IGF-1 were measured from fasting blood samples. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated from glucose and insulin. Fat-free soft tissue (FFST) mass and bone mineral content (BMC) were measured by dual-energy x-ray absorptiometry. Our primary outcome was BMC/height. In our path model, IGF-1 predicted FFST mass (b = 0.018; P = .001), which in turn predicted BMC/height (b = 0.960; P IGF-1 predicted BMC/height (b = 0.001; P = .002), but not after accounting for the mediator of this relationship, FFST mass. The HOMA-IR by IGF-1 interaction negatively predicted FFST mass (b = -0.044; P = .034). HOMA-IR had a significant and negative effect on the muscle-dependent relationship between IGF-1 and BMC/height (b = -0.151; P = .047). Lean body mass is an important intermediary factor in the IGF-1-bone relationship. For this reason, bone development may be compromised indirectly via suboptimal IGF-1-dependent muscle development in insulin-resistant children.

  19. Loss of mass and performance in skeletal muscle tissue: a continuum model

    Directory of Open Access Journals (Sweden)

    Giantesio Giulia

    2018-02-01

    Full Text Available We present a continuum hyperelastic model which describes the mechanical response of a skeletal muscle tissue when its strength and mass are reduced by aging. Such a reduction is typical of a geriatric syndrome called sarcopenia. The passive behavior of the material is described by a hyperelastic, polyconvex, transversely isotropic strain energy function, and the activation of the muscle is modeled by the so called active strain approach. The loss of ability of activating of an elder muscle is then obtained by lowering of some percentage the active part of the stress, while the loss of mass is modeled through a multiplicative decomposition of the deformation gradient. The obtained stress-strain relations are graphically represented and discussed in order to study some of the effects of sarcopenia.

  20. Premature loss of muscle mass and function in type 2 diabetes.

    Science.gov (United States)

    Guerrero, N; Bunout, D; Hirsch, S; Barrera, G; Leiva, L; Henríquez, S; De la Maza, M P

    2016-07-01

    Muscle mass and function are among the most relevant factors that contribute to an optimal quality of life, and are strong predictors of mortality in the elderly. Loss of lean tissues and deterioration of muscle function have been described as one of the many complications of type 2 diabetes mellitus (DM2), but most studies do not isolate age as an intervening factor. To study whether adult DM2 patients up to 60years of age have decreased muscle mass and function compared with healthy non-diabetic (ND) subjects of similar age. Appendicular fat-free mass (ApFFM) by dual X-ray absorptiometry (DEXA), handgrip strength (HS), quadriceps strength (QS), 12 min walking capacity (12MW) and the Timed Up and Go test (TUG) were measured in 100 DM2 patients and 39 ND controls. Muscle quality, or the ratio between lean mass and muscle strength of upper and lower limbs, and the functional limitations associated with pain and stiffness assessed according to the Western Ontario and McMaster Universities Arthrosis Index (WOMAC) were also recorded. Specific tests were performed to rule out microvascular diabetic complications (retinal and peripheral nerves), metabolic control, kidney function and vitamin D status and examine their association with ApFFM and function. ApFFM was significantly higher among DM2 female patients and lower among diabetic men. However opposite results were obtained when individual values were corrected for body mass index (BMI), specifically among women, who were more likely to be obese. As for muscle strength and global functionality tests, significantly better performances in TUG, 12MW, QS and HS were observed among ND subjects of both sexes. These differences prevailed even after excluding diabetic patients with microvascular complications as well as those with more than 10years of diabetes. Muscle quality was also significantly better among ND women. Higher scores of pain and stiffness in the WOMAC scale correlated with 12MW and TUG in both groups but

  1. Strength Exercise Improves Muscle Mass and Hepatic Insulin Sensitivity in Obese Youth

    NARCIS (Netherlands)

    Van Der Heijden, Gert-Jan; Wang, Zhiyue J.; Chu, Zili; Toffolo, Gianna; Manesso, Erica; Sauer, Pieter J. J.; Sunehag, Agneta L.

    VAN DER HEIJDEN, G.-J., Z. J. WANG, Z. CHU, G. TOFFOLO, E. MANESSO, P. J. J. SAUER, and A. L. SUNEHAG. Strength Exercise Improves Muscle Mass and Hepatic Insulin Sensitivity in Obese Youth. Med. Sci. Sports Exerc., Vol. 42, No. 11, pp. 1973-1980, 2010. Introduction: Data on the metabolic effects of

  2. Postoperative loss of skeletal muscle mass, complications and quality of life in patients undergoing cardiac surgery

    NARCIS (Netherlands)

    van Venrooij, Lenny M. W.; Verberne, Hein J.; de Vos, Rien; Borgmeijer-Hoelen, Mieke M. M. J.; van Leeuwen, Paul A. M.; de Mol, Bas A. J. M.

    2012-01-01

    Objective: The objective of this study was to describe postoperative undernutrition in terms of postoperative losses of appendicular skeletal muscle mass (ASMM) with respect to complications, quality of life, readmission, and 1-y mortality after cardiac surgery. Methods: Patients undergoing cardiac

  3. Middle cerebral artery blood velocity depends on cardiac output during exercise with a large muscle mass

    NARCIS (Netherlands)

    Ide, K.; Pott, F.; van Lieshout, J. J.; Secher, N. H.

    1998-01-01

    We tested the hypothesis that pharmacological reduction of the increase in cardiac output during dynamic exercise with a large muscle mass would influence the cerebral blood velocity/perfusion. We studied the relationship between changes in cerebral blood velocity (transcranial Doppler), rectus

  4. Strength Exercise Improves Muscle Mass and Hepatic Insulin Sensitivity in Obese Youth

    NARCIS (Netherlands)

    Van Der Heijden, Gert-Jan; Wang, Zhiyue J.; Chu, Zili; Toffolo, Gianna; Manesso, Erica; Sauer, Pieter J. J.; Sunehag, Agneta L.

    2010-01-01

    VAN DER HEIJDEN, G.-J., Z. J. WANG, Z. CHU, G. TOFFOLO, E. MANESSO, P. J. J. SAUER, and A. L. SUNEHAG. Strength Exercise Improves Muscle Mass and Hepatic Insulin Sensitivity in Obese Youth. Med. Sci. Sports Exerc., Vol. 42, No. 11, pp. 1973-1980, 2010. Introduction: Data on the metabolic effects of

  5. Does Skeletal Muscle Mass Influence Breast Cancer? Evaluating Mammary Tumorigenesis and Progression Genetically Hyper-Muscular Mice

    Science.gov (United States)

    2006-07-01

    the skeletal muscle-specific muscle growth inhibitor myostatin and mice expressing a dominant negative form of the myostatin receptor, Activin...and rates of breast cancer initiation and progression. 15. SUBJECT TERMS Breast cancer, skeletal muscle, myostatin , MPA, DMBA, Activin receptor 16...including interleukins, Insulin-like Growth Factor (IGF) isoforms, IGF-binding proteins and myostatin . To determine the effect of skeletal muscle mass

  6. Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia) : the Longitudinal Aging Study Amsterdam

    NARCIS (Netherlands)

    Visser, Marjolein; Deeg, Dorly J H; Lips, Paul

    2003-01-01

    The age-related change in hormone concentrations has been hypothesized to play a role in the loss of muscle mass and muscle strength with aging, also called sarcopenia. The aim of this prospective study was to investigate whether low serum 25-hydroxyvitamin D (25-OHD) and high serum PTH

  7. Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway

    NARCIS (Netherlands)

    Sandri, M.; Barberi, L.; Bijlsma, A.Y.; Blaauw, B.; Dyar, K.A.; Milan, G.; Mammucari, C.; Meskers, C.G.M.; Pallafacchina, G.; Paoli, A.; Pion, D.; Roceri, M.; Romanello, V.; Serrano, A.L.; Toniolo, L.; Larsson, L.; Maier, A.B.; Munoz-Canoves, P.; Musaro, A.; Pende, M.; Reggiani, C.; Rizzuto, R.; Schiaffino, S.

    2013-01-01

    During ageing skeletal muscles undergo a process of structural and functional remodelling that leads to sarcopenia, a syndrome characterized by loss of muscle mass and force and a major cause of physical frailty. To determine the causes of sarcopenia and identify potential targets for interventions

  8. DYNAMICAL ACCRETION OF PRIMORDIAL ATMOSPHERES AROUND PLANETS WITH MASSES BETWEEN 0.1 AND 5 M {sub ⊕} IN THE HABITABLE ZONE

    Energy Technology Data Exchange (ETDEWEB)

    Stökl, Alexander; Dorfi, Ernst A.; Johnstone, Colin P. [Department of Astrophysics, University of Vienna, Türkenschanzstrasse 17, A-1180 Vienna (Austria); Lammer, Helmut, E-mail: alexander.stoekl@astro.univie.ac.at [Space Research Institute, Austrian Academy of Sciences, Schmiedlstr. 6, A-8042, Graz (Austria)

    2016-07-10

    In the early, disk-embedded phase of evolution of terrestrial planets, a protoplanetary core can accumulate gas from the circumstellar disk into a planetary envelope. In order to relate the accumulation and structure of this primordial atmosphere to the thermal evolution of the planetary core, we calculated atmosphere models characterized by the surface temperature of the core. We considered cores with masses between 0.1 and 5 M {sub ⊕} situated in the habitable zone around a solar-like star. The time-dependent simulations in 1D-spherical symmetry include the hydrodynamics equations, gray radiative transport, and convective energy transport. Using an implicit time integration scheme, we can use large time steps and and thus efficiently cover evolutionary timescales. Our results show that planetary atmospheres, when considered with reference to a fixed core temperature, are not necessarily stable, and multiple solutions may exist for one core temperature. As the structure and properties of nebula-embedded planetary atmospheres are an inherently time-dependent problem, we calculated estimates for the amount of primordial atmosphere by simulating the accretion process of disk gas onto planetary cores and the subsequent evolution of the embedded atmospheres. The temperature of the planetary core is thereby determined from the computation of the internal energy budget of the core. For cores more massive than about one Earth mass, we obtain that a comparatively short duration of the disk-embedded phase (∼10{sup 5} years) is sufficient for the accumulation of significant amounts of hydrogen atmosphere that are unlikely to be removed by later atmospheric escape processes.

  9. Age associated declines in muscle mass, strength, power, and physical performance: impact on fear of falling and quality of life

    Science.gov (United States)

    SUMMARY: This 3 year longitudinal study among older adults showed that declining muscle mass, strength, power, and physical performance are independent contributing factors to increased fear of falling, while declines of muscle mass and physical performance contribute to deterioration of quality of ...

  10. Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength.

    Science.gov (United States)

    Beenakker, Karel G M; Westendorp, Rudi G J; de Craen, Anton J M; Slagboom, Pieternella E; van Heemst, Diana; Maier, Andrea B

    2013-08-01

    In mice, monocytes that exhibit a pro-inflammatory profile enter muscle tissue after muscle injury and are crucial for clearance of necrotic tissue and stimulation of muscle progenitor cell proliferation and differentiation. The aim of this study was to test if pro-inflammatory capacity of classically activated (M1) monocytes relates to muscle mass and strength in humans. This study included 191 male and 195 female subjects (mean age 64.2 years (SD 6.4) and 61.9 ± 6.4, respectively) of the Leiden Longevity Study. Pro-inflammatory capacity of M1 monocytes was assessed by ex vivo stimulation of whole blood with Toll-like receptor (TLR) 4 agonist lipopolysaccharide (LPS) and TLR-2/1 agonist tripalmitoyl-S-glycerylcysteine (Pam₃Cys-SK₄), both M1 phenotype activators. Cytokines that stimulate M1 monocyte response (IFN-γ and GM-CSF) as well as cytokines that are secreted by M1 monocytes (IL-6, TNF-α, IL-12, and IL-1β) were measured. Analyses were adjusted for age, height, and body fat mass. Upon stimulation with LPS, the cytokine production capacity of INF-γ, GM-CSF, and TNF-α was significantly positively associated with lean body mass, appendicular lean mass and handgrip strength in men, but not in women. Upon stimulation with Pam₃Cys-SK₄, IL-6; TNF-α; and Il-1β were significantly positively associated with lean body mass and appendicular lean in women, but not in men. Taken together, this study shows that higher pro-inflammatory capacity of M1 monocytes upon stimulation is associated with muscle characteristics and sex dependent. © 2013 John Wiley & Sons Ltd and the Anatomical Society.

  11. Relationship between Handgrip Strength and Muscle Mass in Female Survivors of Breast Cancer: A Mediation Analysis.

    Science.gov (United States)

    Benavides-Rodríguez, Lorena; García-Hermoso, Antonio; Rodrigues-Bezerra, Diogo; Izquierdo, Mikel; Correa-Bautista, Jorge Enrique; Ramírez-Vélez, Robinson

    2017-07-04

    This study explored the mediating factors of sarcopenia in a group of women survivors of breast cancer in Bogotá, Colombia. This was a descriptive cross-sectional study with 98 women survivors of breast cancer, who were registered with the SIMMON (Integrated Synergies to Improve Oncological Management in Colombia) Foundation. Body weight, height, and waist circumference (WC) were measured, and body mass index (BMI) was calculated. Body composition (percentage of fat and muscle mass) was evaluated via four-pole bioelectrical impedance analysis. Sarcopenia was defined as low muscle mass plus low grip strength or low gait speed (European Working Group on Sarcopenia in Older People (EWGSOP) criteria). A "causal" mediation analysis with the Baron & Kenny procedure (PROCESS ® macro, Columbus, OH, USA) was used to explore variables related to sarcopenia. Analyses were performed with the IBM SPSS 21 statistical package (SPSS Inc., Chicago, IL, USA). The significance level of the results obtained in the hypothesis contrast was p < 0.05. The mean age of the sample was 65.5 ± 5.9 years, with a BMI of 27.8 ± 4.7 kg/m². The prevalence of sarcopenia was 22.4%. Linear regression models suggest a partial mediation of anthropometric parameters (body mass, body mass index and waist circumference) in the association between handgrip strength and muscle mass. In conclusion, one in every five women survivors of breast cancer had sarcopenia. The findings seem to emphasize the importance of obesity prevention in women survivors of breast cancer, suggesting that high handgrip strength may not relate closely to greater muscle mass and therefore would not exclude the risk of sarcopenia.

  12. Muscle mass, BMI, and mortality among adults in the United States: A population-based cohort study.

    Science.gov (United States)

    Abramowitz, Matthew K; Hall, Charles B; Amodu, Afolarin; Sharma, Deep; Androga, Lagu; Hawkins, Meredith

    2018-01-01

    The level of body-mass index (BMI) associated with the lowest risk of death remains unclear. Although differences in muscle mass limit the utility of BMI as a measure of adiposity, no study has directly examined the effect of muscle mass on the BMI-mortality relationship. Body composition was measured by dual-energy x-ray absorptiometry in 11,687 participants of the National Health and Nutrition Examination Survey 1999-2004. Low muscle mass was defined using sex-specific thresholds of the appendicular skeletal muscle mass index (ASMI). Proportional hazards models were created to model associations with all-cause mortality. At any level of BMI ≥22, participants with low muscle mass had higher body fat percentage (%TBF), an increased likelihood of diabetes, and higher adjusted mortality than other participants. Increases in %TBF manifested as 30-40% smaller changes in BMI than were observed in participants with preserved muscle mass. Excluding participants with low muscle mass or adjustment for ASMI attenuated the risk associated with low BMI, magnified the risk associated with high BMI, and shifted downward the level of BMI associated with the lowest risk of death. Higher ASMI was independently associated with lower mortality. Effects were similar in never-smokers and ever-smokers. Additional adjustment for waist circumference eliminated the risk associated with higher BMI. Results were unchanged after excluding unintentional weight loss, chronic illness, early mortality, and participants performing muscle-strengthening exercises or recommended levels of physical activity. Muscle mass mediates associations of BMI with adiposity and mortality and is inversely associated with the risk of death. After accounting for muscle mass, the BMI associated with the greatest survival shifts downward toward the normal range. These results provide a concrete explanation for the obesity paradox.

  13. Protein needs in athletes and dietary-nutrition guidelines to gain muscle mass

    Directory of Open Access Journals (Sweden)

    Aritz Urdampilleta

    2014-05-01

    Full Text Available One of the most important effects of strength training is muscular hypertrophy. Athletes should optimize their nutritional management in order to compensate their own genetic limitations. The aim of this review is to analyze the scientific evidence concerning protein intake as a tool to achieve muscle hypertrophy. Depending on the expenditure and energy intake of athlete, a daily protein ranging between 10-15% of total dietary intake is needed. However in sports diets, it is preferable to estimate the amount of protein needed per kilogram of body weight in each individual. In this regard athletes should ingest an amount between 1.2 g and 1.8 g of proteins/kg of body mass/day to maintain their lean mass. In order to increase muscle mass (0.5 kg/week, athletes should take between 1.6 g and 1.8 g of protein/kg/day with an increase of 400-500 kcal in their daily diet. These needs will depend on the sport, muscular catabolic status, the athlete’s lean mass and glycogen stores. Protein needs will increase if muscle and liver glycogen stores are empty. Excess of protein intake (more than 2 g/kg/day, with full glycogen stores, does not benefit the athlete and could cause an increase in circulating ketones and urea, thereby producing an early dehydration.

  14. Impact of fat mass distribution body shapes on muscles strength and the joints pain

    Directory of Open Access Journals (Sweden)

    Zerf Mohammed

    2016-01-01

    Full Text Available Our study focuses on fat mass distribution body shapes type as measured to determine their effect on skeletal muscle strengthening lumbar extensors (upper and lower limbs where our background confirms that every girl has a natural body type of rectangle, apple, pear, or hourglass. It is good for her to know which type of body shape she is, so she can learn what exercises to do, whereas similar studies suggest that it is much better to challenge weight problems with exercise and dietary measures before resorting to figure shaping. For this purpose, our study was carried out with a total of thirty students, females listed in the Institute of Physical Education and Sport, University of Mostaganem, aged between 20 and 23 years; their homogeneity was based on age, sex, and academic specialty, classified based on the body mass index (BMI into two groups (normal and overweight and based on their body shape′s type into three groups (9 pear shape, 10 rectangle shape, and 11 hourglass shape as a protocol experimental to examine the impact of fat mass distribution body shapes type on lumbar extensor strength. Based on our data analysis, we confirm that the pear and the rectangle shape affect the strength lumbar extensors due to body weight distribution which increases the risks relating to the skeletal muscles. Weight gain is a factor contributing to the weakness of skeletal muscles. However, the body shape explains the anomalies of the distribution of fat mass and BMI risk observed in our sample in the lower and upper part of the body recorded by the values of Killy test and endurance of trunk, the case of the pear and the rectangle shape back pain, which are consisting in excess of the body fat distributed in comparison with less percentage of muscle mass. Whereas this difference can affect the pelvic position.

  15. Brown dwarf accretion: Nonconventional star formation over very long timescales

    Directory of Open Access Journals (Sweden)

    Ćirković Milan M.

    2005-01-01

    Full Text Available We investigate the process of accretion of interstellar gas by the Galactic population of brown dwarfs over very long timescales typical for physical eschatology. In particular, we use the classical Hoyle-Lyttleton-Bondi accretion model to investigate the rate at which brown dwarfs collect enough additional mass to become red dwarfs, accretion-induced changes in the mass function of the low- mass objects, and the corresponding accretion heating of brown dwarfs. In addition, we show how we can make the definition of the final mass function for stellar objects more precise.

  16. Ultrasonographic evaluation of the calf muscle mass and architecture in elderly patients with and without sarcopenia.

    Science.gov (United States)

    Kuyumcu, Mehmet Emin; Halil, Meltem; Kara, Özgür; Çuni, Bledjan; Çağlayan, Gökhan; Güven, Serdar; Yeşil, Yusuf; Arık, Güneş; Yavuz, Burcu Balam; Cankurtaran, Mustafa; Özçakar, Levent

    2016-01-01

    To sonographically assess the muscle mass and architecture of sarcopenic elderly subjects, and to explore the utility of ultrasound (US) measurements in predicting sarcopenia. One hundred elderly subjects were enrolled in this cross-sectional study. Mean age value of our study population was 73.08±6.18years. The diagnosis of sarcopenia was confirmed by measuring fat-free mass index (using bioelectrical impedance analysis) and handgrip strength. Calf circumference was measured and US evaluations comprised bilateral gastrocnemius muscle (MG) thickness, fascicle length and pennate angles; subcutaneous fat and dermis thicknesses in the calf. Bilateral muscle thickness and fascicle length values were significantly lower in patients with sarcopenia (both psarcopenia (all values>76.92%). Gastrocnemius muscle thickness and fascicle length values are lower in sarcopenic elderly and these two parameters can serve as alternative measurements for predicting/quantifying sarcopenia. Calf circumference measurements alone may not be appropriate for assessing sarcopenia. Instead, US imaging can conveniently be used to evaluate different compartments of the musculoskelal system in (sarcopenic) elderly. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  17. Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats.

    Science.gov (United States)

    Shankaran, Mahalakshmi; Shearer, Todd W; Stimpson, Stephen A; Turner, Scott M; King, Chelsea; Wong, Po-Yin Anne; Shen, Ying; Turnbull, Philip S; Kramer, Fritz; Clifton, Lisa; Russell, Alan; Hellerstein, Marc K; Evans, William J

    2016-03-15

    Biomarkers of muscle protein synthesis rate could provide early data demonstrating anabolic efficacy for treating muscle-wasting conditions. Androgenic therapies have been shown to increase muscle mass primarily by increasing the rate of muscle protein synthesis. We hypothesized that the synthesis rate of large numbers of individual muscle proteins could serve as early response biomarkers and potentially treatment-specific signaling for predicting the effect of anabolic treatments on muscle mass. Utilizing selective androgen receptor modulator (SARM) treatment in the ovariectomized (OVX) rat, we applied an unbiased, dynamic proteomics approach to measure the fractional synthesis rates (FSR) of 167-201 individual skeletal muscle proteins in triceps, EDL, and soleus. OVX rats treated with a SARM molecule (GSK212A at 0.1, 0.3, or 1 mg/kg) for 10 or 28 days showed significant, dose-related increases in body weight, lean body mass, and individual triceps but not EDL or soleus weights. Thirty-four out of the 94 proteins measured from the triceps of all rats exhibited a significant, dose-related increase in FSR after 10 days of SARM treatment. For several cytoplasmic proteins, including carbonic anhydrase 3, creatine kinase M-type (CK-M), pyruvate kinase, and aldolase-A, a change in 10-day FSR was strongly correlated (r(2) = 0.90-0.99) to the 28-day change in lean body mass and triceps weight gains, suggesting a noninvasive measurement of SARM effects. In summary, FSR of multiple muscle proteins measured by dynamics of moderate- to high-abundance proteins provides early biomarkers of the anabolic response of skeletal muscle to SARM. Copyright © 2016 the American Physiological Society.

  18. Accreting CO material onto ONe white dwarfs towards accretion-induced collapse

    Science.gov (United States)

    Wu, Cheng-Yuan; Wang, Bo

    2018-03-01

    The final outcomes of accreting ONe white dwarfs (ONe WDs) have been studied for several decades, but there are still some issues that are not resolved. Recently, some studies suggested that the deflagration of oxygen would occur for accreting ONe WDs with Chandrasekhar masses. In this paper, we aim to investigate whether ONe WDs can experience accretion-induced collapse (AIC) or explosions when their masses approach the Chandrasekhar limit. Employing the stellar evolution code Modules for Experiments in Stellar Astrophysics (MESA), we simulate the long-term evolution of ONe WDs with accreting CO material. The ONe WDs undergo weak multicycle carbon flashes during the mass-accretion process, leading to mass increase of the WDs. We found that different initial WD masses and mass-accretion rates influence the evolution of central density and temperature. However, the central temperature cannot reach the explosive oxygen ignition temperature due to neutrino cooling. This work implies that the final outcome of accreting ONe WDs is electron-capture induced collapse rather than thermonuclear explosion.

  19. Foundations of Black Hole Accretion Disk Theory.

    Science.gov (United States)

    Abramowicz, Marek A; Fragile, P Chris

    2013-01-01

    This review covers the main aspects of black hole accretion disk theory. We begin with the view that one of the main goals of the theory is to better understand the nature of black holes themselves. In this light we discuss how accretion disks might reveal some of the unique signatures of strong gravity: the event horizon, the innermost stable circular orbit, and the ergosphere. We then review, from a first-principles perspective, the physical processes at play in accretion disks. This leads us to the four primary accretion disk models that we review: Polish doughnuts (thick disks), Shakura-Sunyaev (thin) disks, slim disks, and advection-dominated accretion flows (ADAFs). After presenting the models we discuss issues of stability, oscillations, and jets. Following our review of the analytic work, we take a parallel approach in reviewing numerical studies of black hole accretion disks. We finish with a few select applications that highlight particular astrophysical applications: measurements of black hole mass and spin, black hole vs. neutron star accretion disks, black hole accretion disk spectral states, and quasi-periodic oscillations (QPOs).

  20. Foundations of Black Hole Accretion Disk Theory

    Directory of Open Access Journals (Sweden)

    Marek A. Abramowicz

    2013-01-01

    Full Text Available This review covers the main aspects of black hole accretion disk theory. We begin with the view that one of the main goals of the theory is to better understand the nature of black holes themselves. In this light we discuss how accretion disks might reveal some of the unique signatures of strong gravity: the event horizon, the innermost stable circular orbit, and the ergosphere. We then review, from a first-principles perspective, the physical processes at play in accretion disks. This leads us to the four primary accretion disk models that we review: Polish doughnuts (thick disks, Shakura-Sunyaev (thin disks, slim disks, and advection-dominated accretion flows (ADAFs. After presenting the models we discuss issues of stability, oscillations, and jets. Following our review of the analytic work, we take a parallel approach in reviewing numerical studies of black hole accretion disks. We finish with a few select applications that highlight particular astrophysical applications: measurements of black hole mass and spin, black hole vs. neutron star accretion disks, black hole accretion disk spectral states, and quasi-periodic oscillations (QPOs.

  1. Hormonal and lifestyle determinants of appendicular skeletal muscle mass in men: the MINOS study.

    Science.gov (United States)

    Szulc, Pawel; Duboeuf, François; Marchand, François; Delmas, Pierre D

    2004-08-01

    Aging-related sarcopenia is characterized by a loss of muscle mass and strength and increased fatigability. However, studies of its determinants in elderly men are scarce. We investigated risk factors for sarcopenia in a large cohort of men. We analyzed 845 men aged 45-85 y who belonged to the MINOS cohort. Lifestyle factors (physical activity, tobacco smoking, alcohol intake, caffeine intake) were evaluated by using a standardized questionnaire. Appendicular skeletal muscle mass (ASM) was estimated by using dual-energy X-ray absorptiometry. The relative appendicular skeletal muscle mass index (RASM) was calculated as ASM/body height(2.3). Apparent free testosterone concentration (AFTC) and free testosterone index (FTI) were calculated on the basis of concentrations of total testosterone and sex hormone-binding globulin. RASM decreased with age (r = -0.29, P values for AFTC, FTI, or 25-hydroxycholecalciferol [25(OH)D] were >2 SDs below the mean for young men had significantly lower RASM than did men with higher values. Men with sarcopenia, defined as the lowest quartile of RASM in the studied cohort (normal RASM, weighed significantly less, smoked more, and spent significantly less time on leisure-time activities. Sarcopenic men also had lower values for testosterone, AFTC, FTI, and 25(OH)D. In elderly men, low physical activity, tobacco smoking, thinness, low testosterone (AFTC and FTI), and decreased 25(OH)D concentrations are risk factors for sarcopenia.

  2. Depression Is Associated With Muscle Mass And Strength In Patients With End Stage Renal Disease

    Directory of Open Access Journals (Sweden)

    Young Rim Song

    2012-06-01

    Full Text Available Depression is the most common psychiatric complication in patients with end-stage renal disease (ESRD. Sarcopenia, defined as loss of muscle mass and strength, is expected to be associated with depression, because both are closely linked to physical inactivity and functional impairment. We investigated the association of sarcopenia with depression in patients with ESRD. A total of 115 patients undergoing hemodialysis (HD were included in this study. Muscle mass was assessed by lean tissue index (LTI using portable whole body bioimpedance spectroscopy, and muscle strength was measured with handgrip strength (HGS. Depression was defined as Beck Depression Inventory-II (BDI-II score ≥16. About 60% of prevalent HD patients had depression. Compared to subjects without depression, depressed patients had a higher prevalence of sarcopenia (45.5 vs. 8.2%, p<0.001 and significantly increased serum IL-6 and hs-CRP level. However, (prealbumin and body mass index (BMI failed to correlate with BDI-II. HGS and LTI had a consistent negative effect on BDI-II even after adjusting other parameters including inflammation. In multivariate analysis, lower , increased IL-6 and β2-microglobulin,and sarcopenia were significant predictors for depression; sarcopenia was most powerful [odds ratio 9.01, 95% CI 3.60-12.22, p=0.001]. In conclusion, the prevalence of sarcopenia and depression was considerably high and and the presence of sarcopenia was an important predictor for depression.

  3. Age- and gender-dependent values of skeletal muscle mass in healthy children and adolescents

    OpenAIRE

    Webber, Colin E.; Barr, Ronald D.

    2011-01-01

    Background Skeletal muscle mass (SMM) can be extracted from whole-body scans obtained by X-ray-based dual-photon absorptiometry (DXA). There is a need to establish expected age-dependent values for children and adolescents. Methods Appendicular lean tissue mass (ALM) was extracted from whole-body DXA scans in 140 healthy children and adolescents (68 females and 72 males). Whole-body SMM was calculated from ALM using equations developed by Kim et al. (Am J Clin Nutr 84:1014–1020, 2006). Age-de...

  4. Measurement of Muscle Protein Fractional Synthetic Rate by Capillary Gas Chromatography/Combustion Isotope Ratio Mass Spectrometry

    OpenAIRE

    Yarasheski, Kevin E.; Smith, Kenneth; Rennie, Michael J.; Bier, Dennis M.

    1992-01-01

    The measurement of skeletal muscle protein fractional synthetic rate using an infusion of (1-13C)leucine and measuring the isotopic abundance of the tracer in skeletal muscle protein by preparative gas chromatography (GC)/ninhydrin isotope ratio mass spectrometry (IRMS) is laborious and subject to errors owing to contamination by 12C. The purpose of this study was to compare muscle (13C)leucine enrichment measured with the conventional preparative GC/ninhydrin IRMS approach to a new, continuo...

  5. Pebble Accretion in Turbulent Protoplanetary Disks

    Science.gov (United States)

    Xu, Ziyan; Bai, Xue-Ning; Murray-Clay, Ruth A.

    2017-09-01

    It has been realized in recent years that the accretion of pebble-sized dust particles onto planetary cores is an important mode of core growth, which enables the formation of giant planets at large distances and assists planet formation in general. The pebble accretion theory is built upon the orbit theory of dust particles in a laminar protoplanetary disk (PPD). For sufficiently large core mass (in the “Hill regime”), essentially all particles of appropriate sizes entering the Hill sphere can be captured. However, the outer regions of PPDs are expected to be weakly turbulent due to the magnetorotational instability (MRI), where turbulent stirring of particle orbits may affect the efficiency of pebble accretion. We conduct shearing-box simulations of pebble accretion with different levels of MRI turbulence (strongly turbulent assuming ideal magnetohydrodynamics, weakly turbulent in the presence of ambipolar diffusion, and laminar) and different core masses to test the efficiency of pebble accretion at a microphysical level. We find that accretion remains efficient for marginally coupled particles (dimensionless stopping time {τ }s˜ 0.1{--}1) even in the presence of strong MRI turbulence. Though more dust particles are brought toward the core by the turbulence, this effect is largely canceled by a reduction in accretion probability. As a result, the overall effect of turbulence on the accretion rate is mainly reflected in the changes in the thickness of the dust layer. On the other hand, we find that the efficiency of pebble accretion for strongly coupled particles (down to {τ }s˜ 0.01) can be modestly reduced by strong turbulence for low-mass cores.

  6. Time-Course of Muscle Mass Loss, Damage, and Proteolysis in Gastrocnemius following Unloading and Reloading: Implications in Chronic Diseases

    Science.gov (United States)

    Chacon-Cabrera, Alba; Lund-Palau, Helena; Gea, Joaquim; Barreiro, Esther

    2016-01-01

    Background Disuse muscle atrophy is a major comorbidity in patients with chronic diseases including cancer. We sought to explore the kinetics of molecular mechanisms shown to be involved in muscle mass loss throughout time in a mouse model of disuse muscle atrophy and recovery following immobilization. Methods Body and muscle weights, grip strength, muscle phenotype (fiber type composition and morphometry and muscle structural alterations), proteolysis, contractile proteins, systemic troponin I, and mitochondrial content were assessed in gastrocnemius of mice exposed to periods (1, 2, 3, 7, 15 and 30 days) of non-invasive hindlimb immobilization (plastic splint, I cohorts) and in those exposed to reloading for different time-points (1, 3, 7, 15, and 30 days, R cohorts) following a seven-day period of immobilization. Groups of control animals were also used. Results Compared to non-exposed controls, muscle weight, limb strength, slow- and fast-twitch cross-sectional areas, mtDNA/nDNA, and myosin content were decreased in mice of I cohorts, whereas tyrosine release, ubiquitin-proteasome activity, muscle injury and systemic troponin I levels were increased. Gastrocnemius reloading following splint removal improved muscle mass loss, strength, fiber atrophy, injury, myosin content, and mtDNA/nDNA, while reducing ubiquitin-proteasome activity and proteolysis. Conclusions A consistent program of molecular and cellular events leading to reduced gastrocnemius muscle mass and mitochondrial content and reduced strength, enhanced proteolysis, and injury, was seen in this non-invasive mouse model of disuse muscle atrophy. Unloading of the muscle following removal of the splint significantly improved the alterations seen during unloading, characterized by a specific kinetic profile of molecular events involved in muscle regeneration. These findings have implications in patients with chronic diseases including cancer in whom physical activity may be severely compromised. PMID

  7. Muscle mass decline, arterial stiffness, white matter hyperintensity, and cognitive impairment: Japan Shimanami Health Promoting Program study.

    Science.gov (United States)

    Kohara, Katsuhiko; Okada, Yoko; Ochi, Masayuki; Ohara, Maya; Nagai, Tokihisa; Tabara, Yasuharu; Igase, Michiya

    2017-08-01

    There is a close association between frailty and cognitive impairment. However, the underlying contribution of sarcopenia to the development of cognitive impairment is unclear. We investigated the possible association between muscle mass decline and cognitive impairment in a cross-sectional study of 1518 subjects aged 55 years or above. We also evaluated arterial stiffness and white matter hyperintensities (WMHs) as possible underlying mechanisms for this association. Two sarcopenic indices were measured: thigh muscle cross-sectional area (CSA; calculated by computed tomography) and skeletal muscle mass (bioelectric impedance). Muscle mass decline was defined as either the bottom 10% or 20% of participants for each sex. Cognitive function was assessed using the Touch Panel-type Dementia Assessment Scale, and brachial-ankle pulse wave velocity was measured as an index of arterial stiffness. Both sarcopenic indices were modestly but significantly associated with brachial-ankle pulse wave velocity in male and female subjects. The presence of WMHs was significantly associated with low thigh muscle CSA in men and with low skeletal muscle mass in women. The Touch Panel-type Dementia Assessment Scale score was modestly but significantly and positively associated with thigh muscle CSA in men and skeletal muscle mass in women. Muscle mass decline in the bottom 10% of participants on both sarcopenic indices was significantly and independently related to cognitive impairment in women. Lower sarcopenic indices are significantly related to lower cognitive scores. Arterial stiffness and WMHs could account, at least in part, for this association. © 2017 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders.

  8. Estimation of thigh muscle mass with magnetic resonance imaging in older adults and people with chronic obstructive pulmonary disease.

    Science.gov (United States)

    Mathur, Sunita; Takai, Karen Pr; Macintyre, Donna L; Reid, Darlene

    2008-02-01

    Quantifying muscle mass is an essential part of physical therapy assessment, particularly in older adults and in people with chronic conditions associated with muscle atrophy. The purposes of this study were to examine the relationship between muscle cross-sectional area (CSA) and volume by use of magnetic resonance imaging (MRI) and to compare anthropometric estimations of midthigh CSA with measurements obtained from MRI. Twenty older adults who were healthy and 20 people with chronic obstructive pulmonary disease (COPD), matched for age, sex, and body mass index, underwent MRI to obtain measurements of thigh muscle CSA and volume. Anthropometric measurements (skinfold thickness and thigh circumference) were used to estimate midthigh CSA. Muscle volumes were significantly lower in the people with COPD than in the older adults who were healthy. Moderate to high correlations were found between midthigh CSA and volume in both groups (r=.61-.94). Anthropometric measurements tended to overestimate midthigh CSA in both the people with COPD (estimated CSA=64.9+/-17.8; actual CSA=48.3+/-10.2 cm(2)) and the older adults who were healthy (estimated quadriceps femoris muscle CSA=65.0+/-14.0; actual CSA=56.8+/-13.5 cm(2)). Furthermore, the estimated quadriceps femoris muscle CSAs were not sensitive enough to detect a difference in muscle size between people with COPD and controls. Thigh circumference alone was not different between groups and showed only low to moderate correlations with muscle volume (r=.19-.47). Muscle CSA measured from a single slice provides a good indication of volume, but the most representative slice should be chosen on the basis of the muscle group of interest. Thigh circumference is not correlated with muscle volume and, therefore, should not be used as an indicator of muscle size. The development of population-specific reference equations for estimating muscle CSA from anthropometric measurements is warranted.

  9. Fat and muscle mass in different groups of pre-pubertal and pubertal rural children. Cross-cultural comparisons between Sahelian (rural Senegal) and Amazonian (Beni River, Bolivia) children.

    Science.gov (United States)

    Benefice, Eric; Luna Monrroy, Selma J; Lopez Rodriguez, Ronald W; Ndiaye, Gnagna

    2011-07-01

    An increase in fat accretion is essential for triggering the puberty spurt. Hence, nutritional constraints may influence puberty timing. To measure changes in fat and muscle mass in children living in natural environments but with different nutritional exposures. Cross-comparisons of children from rural Senegal and lowland (Amazonian) Bolivia were carried out. Anthropometric measurements of stature, weight, four subcutaneous skin-folds (triceps, biceps, subscapular, supra-iliac) and arm circumference were made. Children were divided into two age groups (5-9.9-year-olds or 'pre pubescents' (n = 381) and 10-15-year-olds or 'pubescents' (n = 692)). Senegalese girls menstruated later than Bolivian girls and Senegalese boys also matured later than Bolivian boys. Bolivian children displayed more fat and muscle before puberty and during puberty than the Senegalese. They also had more fat deposited on the trunk. There were substantial differences in living conditions and nutritional patterns between both locations. In Senegal, nutritional stress is likely to appear early during in utero life and to persist throughout the growth period, including puberty. This leads to a deficit in fat accretion before and during puberty that is associated with a considerable delay in puberty occurrence. In Bolivia, such stress is far less severe. Variability in puberty should be analysed taking into account these differences.

  10. Supplementing Breakfast with a Vitamin D and Leucine-Enriched Whey Protein Medical Nutrition Drink Enhances Postprandial Muscle Protein Synthesis and Muscle Mass in Healthy Older Men.

    Science.gov (United States)

    Chanet, Audrey; Verlaan, Sjors; Salles, Jérôme; Giraudet, Christophe; Patrac, Véronique; Pidou, Véronique; Pouyet, Corinne; Hafnaoui, Nordine; Blot, Adeline; Cano, Noël; Farigon, Nicolas; Bongers, Anke; Jourdan, Marion; Luiking, Yvette; Walrand, Stéphane; Boirie, Yves

    2017-12-01

    Background: A promising strategy to help older adults preserve or build muscle mass is to optimize muscle anabolism through providing an adequate amount of high-quality protein at each meal. Objective: This "proof of principle" study investigated the acute effect of supplementing breakfast with a vitamin D and leucine-enriched whey protein medical nutrition drink on postprandial muscle protein synthesis and longer-term effect on muscle mass in healthy older adults. Methods: A randomized, placebo-controlled, double-blind study was conducted in 24 healthy older men [mean ± SD: age 71 ± 4 y; body mass index (in kg/m 2 ) 24.7 ± 2.8] between September 2012 and October 2013 at the Unit of Human Nutrition, University of Auvergne, Clermont-Ferrand, France. Participants received a medical nutrition drink [test group; 21 g leucine-enriched whey protein, 9 g carbohydrates, 3 g fat, 800 IU cholecalciferol (vitamin D 3 ), and 628 kJ] or a noncaloric placebo (control group) before breakfast for 6 wk. Mixed muscle protein fractional synthesis rate (FSR) was measured at week 0 in the basal and postprandial state, after study product intake with a standardized breakfast with the use of l-[ 2 H 5 ]-phenylalanine tracer methodology. The longer-term effect of the medical nutrition drink was evaluated by measurement of appendicular lean mass, representing skeletal muscle mass at weeks 0 and 6, by dual-energy X-ray absorptiometry. Results: Postprandial FSR (0-240 min) was higher in the test group than in the control group [estimate of difference (ED): 0.022%/h; 95% CI: 0.010%/h, 0.035%/h; ANCOVA, P = 0.001]. The test group gained more appendicular lean mass than the control group after 6 wk (ED: 0.37 kg; 95% CI: 0.03, 0.72 kg; ANCOVA, P = 0.035), predominantly as leg lean mass (ED: 0.30 kg; 95% CI: 0.03, 0.57 kg; ANCOVA, P = 0.034). Conclusions: Supplementing breakfast with a vitamin D and leucine-enriched whey protein medical nutrition drink stimulated postprandial muscle protein

  11. Skeletal muscle mass and quality as risk factors for postoperative outcome after open colon resection for cancer

    NARCIS (Netherlands)

    Boer, B. C.; de Graaff, F.; Brusse-Keizer, M.; Bouman, D. E.; Slump, C. H.; Slee-Valentijn, M.; Klaase, J. M.

    The prevalence of colorectal cancer in the elderly is increasing and, therefore, surgical interventions with a risk of potential complications are more frequently performed. This study investigated the role of low skeletal muscle mass (sarcopenia), muscle quality, and the sarcopenic obesity as

  12. Loss of Muscle Mass During Chemotherapy Is Predictive for Poor Survival of Patients With Metastatic Colorectal Cancer

    NARCIS (Netherlands)

    Blauwhoff-Buskermolen, Susanne; Versteeg, Kathelijn S.; de van der Schueren, Marian A. E.; den Braver, Nicole R.; Berkhof, Johannes; Langius, Jacqueline A. E.; Verheul, Henk M. W.

    2016-01-01

    Low muscle mass is present in approximately 40% of patients with metastatic colorectal cancer (mCRC) and may be associated with poor outcome. We studied change in skeletal muscle during palliative chemotherapy in patients with mCRC and its association with treatment modifications and overall

  13. LOW MID-UPPER ARM CIRCUMFERENCE AND MORTALITY IN OLDER PERSONS: THE INFLUENCE OF FAT AND MUSCLE MASS

    NARCIS (Netherlands)

    Delmonico, M.J.; Harris, T.B.; Visser, M.; Park, S.W.; Conroy, M.B.; Velasquez-Mieyer, P.; Boudreau, R.; Manini, T.M.; Nevitt, M.; Newman, A.B.; Goodpaster, B.H.

    2009-01-01

    Background: Sarcopenia is thought to be accompanied by increased muscle fat infiltration. However, no longitudinal studies have examined concomitant changes in muscle mass, strength, or fat infiltration in older adults. Objective: We present longitudinal data on age-related changes in leg

  14. The effects of dietary protein intake on appendicular lean mass and muscle function in elderly men

    DEFF Research Database (Denmark)

    Mitchell, Cameron J; Milan, Amber M; Mitchell, Sarah M

    2017-01-01

    Background: The Recommended Daily Allowance (RDA) for protein intake in the adult population is widely promoted as 0.8 g · kg-1 · d-1 Aging may increase protein requirements, particularly to maintain muscle mass.Objective: We investigated whether controlled protein consumption at the current RDA...... or twice the RDA (2RDA) affects skeletal muscle mass and physical function in elderly men.Design: In this parallel-group randomized trial, 29 men aged >70 y [mean ± SD body mass index (in kg/m2): 28.3 ± 4.2] were provided with a complete diet containing either 0.8 (RDA) or 1.6 (2RDA) g protein · kg-1 · d-1...... energy balance (mean ± SD RDA: 209 ± 213 kcal/d; 2RDA 145 ± 214 kcal/d; P= 0.427 for difference between the groups). In comparison with RDA, whole-body lean mass increased in 2RDA (P = 0.001; 1.49 ± 1.30 kg, P

  15. Accreting Black Holes

    OpenAIRE

    Begelman, Mitchell C.

    2014-01-01

    I outline the theory of accretion onto black holes, and its application to observed phenomena such as X-ray binaries, active galactic nuclei, tidal disruption events, and gamma-ray bursts. The dynamics as well as radiative signatures of black hole accretion depend on interactions between the relatively simple black-hole spacetime and complex radiation, plasma and magnetohydrodynamical processes in the surrounding gas. I will show how transient accretion processes could provide clues to these ...

  16. Texture-modified diets are associated with decreased muscle mass in older adults admitted to a rehabilitation ward.

    Science.gov (United States)

    Shimizu, Akio; Maeda, Keisuke; Tanaka, Kei; Ogawa, Mei; Kayashita, Jun

    2018-05-01

    Texture-modified diets (TMD) have significantly lower energy and protein content than normal diets. Therefore, TMD can cause malnutrition and loss of muscle mass. However, few studies have reported the relationship between TMD and decreased skeletal muscle mass. The aim of the present study was to clarify the association between TMD and decreased skeletal muscle mass. We reviewed data of 188 older adult patients who were admitted to a rehabilitation hospital. TMD were defined based on the Japanese Dysphagia Diet Criteria 2013 proposed by the Japanese Society of Dysphagia Rehabilitation. The Mini Nutritional Assessment-Short Form was used to assess nutritional status; dual-energy X-ray absorptiometry was used to measure the skeletal muscle mass index, and the cut-off values for decreased skeletal muscle mass index were based on the Asian Working Group for Sarcopenia; the Functional Independence Measure was used to evaluate activities of daily living. The patients' mean age was 80.6 ± 7.5 years, and 62% were women. A total of 22 patients (11.7%) consumed TMD. A total of 104 patients (55.3%) had decreased skeletal muscle mass, and approximately 90% of them consumed TMD. Decreased skeletal muscle mass index (odds ratio 7.199, 95% confidence interval 1.489-34.805, P ≤ 0.01) and Functional Independence Measure scores (odds ratio 0.972, 95% confidence interval 0.952-0.992, P ≤ 0.01) were independently related to TMD in the multivariate analysis. The TMD group was associated with decreased skeletal muscle mass. Future, prospective studies are necessary to investigate causality. Geriatr Gerontol Int 2018; 18: 698-704. © 2017 Japan Geriatrics Society.

  17. A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys.

    Science.gov (United States)

    St Andre, Michael; Johnson, Mark; Bansal, Prashant N; Wellen, Jeremy; Robertson, Andrew; Opsahl, Alan; Burch, Peter M; Bialek, Peter; Morris, Carl; Owens, Jane

    2017-11-09

    The treatments currently approved for Duchenne muscular dystrophy (DMD), a progressive skeletal muscle wasting disease, address the needs of only a small proportion of patients resulting in an urgent need for therapies that benefit all patients regardless of the underlying mutation. Myostatin is a member of the transforming growth factor-β (TGF-β) family of ligands and is a negative regulator of skeletal muscle mass. Loss of myostatin has been shown to increase muscle mass and improve muscle function in both normal and dystrophic mice. Therefore, myostatin blockade via a specific antibody could ameliorate the muscle weakness in DMD patients by increasing skeletal muscle mass and function, thereby reducing patients' functional decline. A murine anti-myostatin antibody, mRK35, and its humanized analog, domagrozumab, were developed and their ability to inhibit several TGB-β ligands was measured using a cell-based Smad-activity reporter system. Normal and mdx mice were treated with mRK35 to examine the antibody's effect on body weight, lean mass, muscle weights, grip strength, ex vivo force production, and fiber size. The humanized analog (domagrozumab) was tested in non-human primates (NHPs) for changes in skeletal muscle mass and volume as well as target engagement via modulation of circulating myostatin. Both the murine and human antibodies are specific and potent inhibitors of myostatin and GDF11. mRK35 is able to increase body weight, lean mass, and muscle weights in normal mice. In mdx mice, mRK35 significantly increased body weight, muscle weights, grip strength, and ex vivo force production in the extensor digitorum longus (EDL) muscle. Further, tibialis anterior (TA) fiber size was significantly increased. NHPs treated with domagrozumab demonstrated a dose-dependent increase in lean mass and muscle volume and exhibited increased circulating levels of myostatin demonstrating target engagement. We demonstrated that the potent anti-myostatin antibody mRK35 and

  18. Misaligned Accretion and Jet Production

    Science.gov (United States)

    King, Andrew; Nixon, Chris

    2018-04-01

    Disk accretion onto a black hole is often misaligned from its spin axis. If the disk maintains a significant magnetic field normal to its local plane, we show that dipole radiation from Lense–Thirring precessing disk annuli can extract a significant fraction of the accretion energy, sharply peaked toward small disk radii R (as R ‑17/2 for fields with constant equipartition ratio). This low-frequency emission is immediately absorbed by surrounding matter or refracted toward the regions of lowest density. The resultant mechanical pressure, dipole angular pattern, and much lower matter density toward the rotational poles create a strong tendency to drive jets along the black hole spin axis, similar to the spin-axis jets of radio pulsars, also strong dipole emitters. The coherent primary emission may explain the high brightness temperatures seen in jets. The intrinsic disk emission is modulated at Lense–Thirring frequencies near the inner edge, providing a physical mechanism for low-frequency quasi-periodic oscillations (QPOs). Dipole emission requires nonzero hole spin, but uses only disk accretion energy. No spin energy is extracted, unlike the Blandford–Znajek process. Magnetohydrodynamic/general-relativistic magnetohydrodynamic (MHD/GRMHD) formulations do not directly give radiation fields, but can be checked post-process for dipole emission and therefore self-consistency, given sufficient resolution. Jets driven by dipole radiation should be more common in active galactic nuclei (AGN) than in X-ray binaries, and in low accretion-rate states than high, agreeing with observation. In non-black hole accretion, misaligned disk annuli precess because of the accretor’s mass quadrupole moment, similarly producing jets and QPOs.

  19. Lean muscle mass in classic or ovulatory PCOS: association with central obesity and insulin resistance.

    Science.gov (United States)

    Mario, F M; do Amarante, F; Toscani, M K; Spritzer, P M

    2012-10-01

    This age-matched case-control study assessed total and segmental lean muscle mass in classic or ovulatory polycystic ovary syndrome (PCOS) patients and investigated whether lean mass is associated with hormone and metabolic features. Participants underwent anthropometric and clinical evaluation. Habitual physical activity was assessed with a digital pedometer, and body composition by dual-energy X-ray absorptiometry. Laboratory measurements included total cholesterol, cholesterol fractions, triglycerides, glucose, total serum testosterone, serum insulin, estradiol, luteinizing hormone, and SHBG. Energy intake was calculated using a food frequency questionnaire. Classic PCOS patients had higher body mass index (BMI), waist circumference, testosterone and lipid accumulation product values than ovulatory PCOS and controls. Energy consumption, homeostasis model assessment index, SHBG, free androgen index and triglycerides, total and trunk lean mass were higher only in classic PCOS women vs. controls. Arm, leg, trunk, total or limb lean masses were not correlated with hormone levels in any of the groups. However, in PCOS women lipid accumulation product was positively correlated with total (r=0.56, p=0.001), trunk (r=0.59, p=0.001), arm (r=0.54, p=0.001), leg (r=0.44, p=0.03) and limb (r=0.48, p=0.001) lean masses. BMI was positively correlated with all lean mass segments and independently associated with total lean mass. Lipid accumulation product and BMI were independently associated with trunk lean mass variation. The increase in lean mass in classic PCOS appears to be associated with insulin resistance and central obesity rather than with energy intake, physical activity or androgens. © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.

  20. Initial Presentation of Renal Cell Carcinoma as a Metastatic Mass within the Masseter Muscle: A Case Report and Literature Review

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Kyung Eun; Lee, Han Bee; Cho, Woo Ho; Kim, Jae Hyung; Lee, Ji Hae; Kang, Min Jin [Dept. of Radiology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of); Kim, Hyun Jung [Dept. of Pathology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of)

    2012-02-15

    Renal cell carcinoma (RCC) is often concomitant with distant metastasis, and these metastases are the first sign of an otherwise occult primary. Whereas metastasis of RCC to the head and neck has been reported, metastasis to the masseter muscle, which is composed of skeletal muscle, is quite rare. We now report the case of a 66-year-old man who had a past history of pulmonary tuberculosis, with RCC metastasis of a well-defined intensely enhancing hypervascular mass in the masseter muscle as the initial presentation. We present the imaging findings of this case and a literature review about radiologic differential diagnosis of intramasseteric masses.

  1. Type VI collagen turnover-related peptides—novel serological biomarkers of muscle mass and anabolic response to loading in young men

    DEFF Research Database (Denmark)

    Nedergaard, Anders; Sun, Shu; Karsdal, Morten A

    2013-01-01

    Immobilization-induced loss of muscle mass is a complex phenomenon with several parallels to sarcopenic and cachectic muscle loss. Muscle is a large organ with a protein turnover that is orders of magnitude larger than most other tissues. Thus, we hypothesize that muscle loss and regain is reflec...

  2. The role of fat mass and skeletal muscle mass in knee osteoarthritis is different for men and women: the NEO study

    NARCIS (Netherlands)

    Visser, A.W. de; Mutsert, R. de; Loef, M.; Cessie, S. le; Heijer, M. den; Bloem, J.L.; Reijnierse, M.; Rosendaal, F.R.; Kloppenburg, M.; Assendelft, W.J.J.; Smit, J.W.A.; et al.,

    2014-01-01

    OBJECTIVE: To investigate if the amount of fat mass (FM) or skeletal muscle mass (SMM) is more strongly associated with knee osteoarthritis (OA), in both men and women. METHODS: The Netherlands Epidemiology of Obesity (NEO) study is a population-based cohort aged 45-65 years, including 5313

  3. Measuring the spins of accreting black holes

    International Nuclear Information System (INIS)

    McClintock, Jeffrey E; Narayan, Ramesh; Gou, Lijun; Kulkarni, Akshay; Penna, Robert F; Steiner, James F; Davis, Shane W; Orosz, Jerome A; Remillard, Ronald A

    2011-01-01

    A typical galaxy is thought to contain tens of millions of stellar-mass black holes, the collapsed remnants of once massive stars, and a single nuclear supermassive black hole. Both classes of black holes accrete gas from their environments. The accreting gas forms a flattened orbiting structure known as an accretion disk. During the past several years, it has become possible to obtain measurements of the spins of the two classes of black holes by modeling the x-ray emission from their accretion disks. Two methods are employed, both of which depend upon identifying the inner radius of the accretion disk with the innermost stable circular orbit, whose radius depends only on the mass and spin of the black hole. In the Fe Kα method, which applies to both classes of black holes, one models the profile of the relativistically broadened iron line with a special focus on the gravitationally redshifted red wing of the line. In the continuum-fitting (CF) method, which has so far only been applied to stellar-mass black holes, one models the thermal x-ray continuum spectrum of the accretion disk. We discuss both methods, with a strong emphasis on the CF method and its application to stellar-mass black holes. Spin results for eight stellar-mass black holes are summarized. These data are used to argue that the high spins of at least some of these black holes are natal, and that the presence or absence of relativistic jets in accreting black holes is not entirely determined by the spin of the black hole.

  4. Relative muscle mass and the risk of incident type 2 diabetes: A cohort study.

    Directory of Open Access Journals (Sweden)

    Sungwoo Hong

    Full Text Available The association between relative muscle mass (RMM and incidence of type 2 diabetes (T2DM is largely unknown. We examined whether RMM predicted development of T2DM in an apparently young healthy population.This cohort study was comprised of 113,913 men and 89,854 women, free of T2DM at baseline, who underwent a health checkup examination and were followed-up annually or biennially for an average of 2.9 years. We used skeletal muscle mass index (SMI as an indicator of RMM. SMI (% [total skeletal muscle mass (kg/body weight (kg×100] was estimated using a bioelectrical impedance analyzer. The study outcome was incident T2DM, defined as fasting serum glucose ≥126 mg/dL, HbA1C ≥6.5%, or use of medication for T2DM.During 589,098.8 person-years of follow-up, 4,264 individuals developed T2DM (incidence rate, 7.2 per 1000 person-years. Median age (range at baseline was 39.1 years (18.1-87.1. RMM was negatively associated with incidence of T2DM in a dose-response manner. The multivariate-adjusted hazard ratios (95% CIs for incident T2DM comparing quartiles 3, 2 and 1 of RMM to the highest quartile were 1.32 (1.14-1.52, 1.63 (1.42-1.86, and 2.21 (1.94-2.51, respectively, for males and 1.18 (0.88-1.58, 1.46 (1.11-1.91, and 1.96 (01.51-2.53 for females (P for trend <0.001; 0.011. This association was stronger in younger or premenopausal subjects.RMM was negatively associated with development of T2DM in a large sample of young and middle-aged Korean adults. Further research is required to determine whether preservation of muscle mass through intervention affects the risk of T2DM.

  5. Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79 : the health, aging and body composition study

    NARCIS (Netherlands)

    Visser, Marjolein; Kritchevsky, Stephen B; Goodpaster, Bret H; Newman, Anne B; Nevitt, Michael; Stamm, Elizabeth; Harris, Tamara B

    OBJECTIVES: The loss of muscle mass with aging, or sarcopenia, is hypothesized to be associated with the deterioration of physical function. Our aim was to determine whether low leg muscle mass and greater fat infiltration in the muscle were associated with poor lower extremity performance (LEP).

  6. The effect of individualized nutritional counseling on muscle mass and treatment outcome in patients with metastatic colorectal cancer undergoing chemotherapy: a randomized controlled trial protocol

    NARCIS (Netherlands)

    van der Werf, Anne; Blauwhoff-Buskermolen, Susanne; Langius, Jacqueline A. E.; Berkhof, Johannes; Verheul, Henk M. W.; de van der Schueren, Marian A. E.

    2015-01-01

    A low muscle mass is prevalent in patients with metastatic colorectal cancer (mCRC) and has been associated with poor treatment outcome. Chemotherapeutic treatment has an additional unfavorable effect on muscle mass. Sufficient protein intake and physical activity are known to induce muscle protein

  7. He stars and He-accreting CO white dwarfs

    International Nuclear Information System (INIS)

    Limongi, M.; Tornambe, A.

    1991-01-01

    He star models in the mass range 0.4-1.0 solar mass have been evolved until the red giant phase or, depending on their mass, until crystallization on the white-dwarf cooling sequence. Some of the degenerate structures obtained in these computations have been successively accreted at various He accretion rates in order to better define the fate of the accreting dwarf versus its mass and accretion rate for a fixed degeneracy level of the accreting dwarf. He stars have been further induced to transfer mass to a degenerate companion through Roche lobe overflow, in conditions of large gravitational wave radiation by the system. CO dwarfs in binary systems with He stars are found to experience a thermal behavior whose effects are such to locate the structure on the verge of obtaining a strong SN-like explosive event. 22 refs

  8. Baseline muscle mass is a poor predictor of functional overload-induced gain in the mouse model

    Directory of Open Access Journals (Sweden)

    Audrius Kilikevicius

    2016-11-01

    Full Text Available Genetic background contributes substantially to individual variability in muscle mass. Muscle hypertrophy in response to resistance training can also vary extensively. However, it is less clear if muscle mass at baseline is predictive of the hypertrophic response.The aim of this study was to examine the effect of genetic background on variability in muscle mass at baseline and in the adaptive response of the mouse fast- and slow-twitch muscles to overload. Males of eight laboratory mouse strains: C57BL/6J (B6, n=17, BALB/cByJ (n=7, DBA/2J (D2, n=12, B6.A-(rs3676616-D10Utsw1/Kjn (B6.A, n=9, C57BL/6J-Chr10A/J/NaJ (B6.A10, n=8, BEH+/+ (n=11, BEH (n=12 and DUHi (n=12, were studied. Compensatory growth of soleus and plantaris muscles was triggered by a 4-week overload induced by synergist unilateral ablation. Muscle weight in the control leg (baseline varied from 5.2±07 mg soleus and 11.4±1.3 mg plantaris in D2 mice to 18.0±1.7 mg soleus in DUHi and 43.7±2.6 mg plantaris in BEH (p<0.001 for both muscles. In addition, soleus in the B6.A10 strain was ~40% larger (p<0.001 compared to the B6. Functional overload increased muscle weight, however, the extent of gain was strain-dependent for both soleus (p<0.01 and plantaris (p<0.02 even after accounting for the baseline differences. For the soleus muscle, the BEH strain emerged as the least responsive, with a 1.3-fold increase, compared to a 1.7-fold gain in the most responsive D2 strain, and there was no difference in the gain between the B6.A10 and B6 strains. The BEH strain appeared the least responsive in the gain of plantaris as well, 1.3-fold, compared to ~1.5-fold gain in the remaining strains. We conclude that variation in muscle mass at baseline is not a reliable predictor of that in the overload-induced gain. This suggests that a different set of genes influence variability in muscle mass acquired in the process of normal development, growth and maintenance, and in the process of adaptive

  9. Accretion of Ghost Condensate by Black Holes

    Energy Technology Data Exchange (ETDEWEB)

    Frolov, A

    2004-06-02

    The intent of this letter is to point out that the accretion of a ghost condensate by black holes could be extremely efficient. We analyze steady-state spherically symmetric flows of the ghost fluid in the gravitational field of a Schwarzschild black hole and calculate the accretion rate. Unlike minimally coupled scalar field or quintessence, the accretion rate is set not by the cosmological energy density of the field, but by the energy scale of the ghost condensate theory. If hydrodynamical flow is established, it could be as high as tenth of a solar mass per second for 10MeV-scale ghost condensate accreting onto a stellar-sized black hole, which puts serious constraints on the parameters of the ghost condensate model.

  10. Gravitomagnetic acceleration from black hole accretion disks

    International Nuclear Information System (INIS)

    Poirier, J; Mathews, G J

    2016-01-01

    We demonstrate how the motion of the neutral masses in an accretion disk orbiting a black hole creates a general-relativistic magnetic-like (gravitomagnetic) field that vertically accelerates neutral particles near an accretion disk upward and then inward toward the axis of the accretion disk. Even though this gravitomagnetic field is not the only mechanism contributing to the production of jets, it presents a novel means to identify one general relativistic effect from a much more complicated problem. In addition, as the accelerated material above or below the accretion disk nears the axis with a nearly vertical direction, a frame-dragging effect twists the trajectories around the axis thus contributing to the collimation of the jet. (note)

  11. Gravitomagnetic acceleration from black hole accretion disks

    Science.gov (United States)

    Poirier, J.; Mathews, G. J.

    2016-05-01

    We demonstrate how the motion of the neutral masses in an accretion disk orbiting a black hole creates a general-relativistic magnetic-like (gravitomagnetic) field that vertically accelerates neutral particles near an accretion disk upward and then inward toward the axis of the accretion disk. Even though this gravitomagnetic field is not the only mechanism contributing to the production of jets, it presents a novel means to identify one general relativistic effect from a much more complicated problem. In addition, as the accelerated material above or below the accretion disk nears the axis with a nearly vertical direction, a frame-dragging effect twists the trajectories around the axis thus contributing to the collimation of the jet.

  12. Review of gravitomagnetic acceleration from accretion disks

    Science.gov (United States)

    Poirier, J.; Mathews, G. J.

    2015-11-01

    We review the development of the equations of gravitoelectromagnetism and summarize how the motion of the neutral masses in an accretion disk orbiting a black hole creates a general-relativistic magnetic-like (gravitomagnetic) field that vertically accelerates neutral particles near the accretion disk upward and then inward toward the axis of the accretion disk. Even though this gravitomagnetic field is not the only mechanism to produce collimated jets, it is a novel means to identify one general relativistic effect from a much more complicated problem. In addition, as the accelerated material above or below the accretion disk nears the axis with a nearly vertical direction, a frame-dragging effect twists the trajectories around the axis thus contributing to the collimation of the jet.

  13. Per meal dose and frequency of protein consumption is associated with lean mass and muscle performance.

    Science.gov (United States)

    Loenneke, Jeremy P; Loprinzi, Paul D; Murphy, Caoileann H; Phillips, Stuart M

    2016-12-01

    It has been hypothesized that for older adults evenly distributing consumption of protein at 30-40 g per meal throughout the day may result in more favorable retention of lean mass and muscular strength. Such a thesis has not, to our knowledge, been tested outside of short-term studies or acute measures of muscle protein synthesis. To examine whether the number of times an individual consumed a minimum of 30 g of protein at a meal is associated with leg lean mass and knee extensor strength. Data from the 1999-2002 NHANES were used, with 1081 adults (50-85 y) constituting the analytic sample. A "multiple pass" 24-h dietary interview format was used to collect detailed information about the participants' dietary intake. Knee extensor strength was assessed objectively using the Kin Com MP dynamometer. Leg lean mass was estimated from whole-body dual-energy X-ray absorptiometry (DXA) scans. Participants with 1 vs. 0 (β adjusted  = 23.6, p = 0.002) and 2 vs. 0 (β adjusted  = 51.1, p = 0.001) meals of ≥30 g protein/meal had greater strength and leg lean mass (1 vs. 0, β adjusted  = 1160, p frequency with leg lean mass and strength plateaued at ∼45 g protein/meal for those consuming 2 vs. 0 meals above the evaluated protein/meal threshold. However, for those with only 1 meal at or above the evaluated threshold, the response plateaued at 30 g/meal. Leg lean mass mediated the relationship between protein frequency and strength, with the proportion of the total effect mediated being 64%. We found that more frequent consumption of meals containing between 30 and 45 g protein/meal produced the greatest association with leg lean mass and strength. Thus, the consumption of 1-2 daily meals with protein content from 30 to 45 g may be an important strategy for increasing and/or maintaining lean body mass and muscle strength with aging. Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  14. Reduced bone mass and muscle strength in male 5α-reductase type 1 inactivated mice.

    Directory of Open Access Journals (Sweden)

    Sara H Windahl

    Full Text Available Androgens are important regulators of bone mass but the relative importance of testosterone (T versus dihydrotestosterone (DHT for the activation of the androgen receptor (AR in bone is unknown. 5α-reductase is responsible for the irreversible conversion of T to the more potent AR activator DHT. There are two well established isoenzymes of 5α-reductase (type 1 and type 2, encoded by separate genes (Srd5a1 and Srd5a2. 5α-reductase type 2 is predominantly expressed in male reproductive tissues whereas 5α-reductase type 1 is highly expressed in liver and moderately expressed in several other tissues including bone. The aim of the present study was to investigate the role of 5α-reductase type 1 for bone mass using Srd5a1⁻/⁻ mice. Four-month-old male Srd5a1⁻/⁻ mice had reduced trabecular bone mineral density (-36%, p<0.05 and cortical bone mineral content (-15%, p<0.05 but unchanged serum androgen levels compared with wild type (WT mice. The cortical bone dimensions were reduced in the male Srd5a1⁻/⁻ mice as a result of a reduced cortical periosteal circumference compared with WT mice. T treatment increased the cortical periosteal circumference (p<0.05 in orchidectomized WT mice but not in orchidectomized Srd5a1⁻/⁻ mice. Male Srd5a1⁻/⁻ mice demonstrated a reduced forelimb muscle grip strength compared with WT mice (p<0.05. Female Srd5a1⁻/⁻ mice had slightly increased cortical bone mass associated with elevated circulating levels of androgens. In conclusion, 5α-reductase type 1 inactivated male mice have reduced bone mass and forelimb muscle grip strength and we propose that these effects are due to lack of 5α-reductase type 1 expression in bone and muscle. In contrast, the increased cortical bone mass in female Srd5a1⁻/⁻ mice, is an indirect effect mediated by elevated circulating androgen levels.

  15. Numerical Simulations of Wind Accretion in Symbiotic Binaries

    Science.gov (United States)

    de Val-Borro, M.; Karovska, M.; Sasselov, D.

    2009-08-01

    About half of the binary systems are close enough to each other for mass to be exchanged between them at some point in their evolution, yet the accretion mechanism in wind accreting binaries is not well understood. We study the dynamical effects of gravitational focusing by a binary companion on winds from late-type stars. In particular, we investigate the mass transfer and formation of accretion disks around the secondary in detached systems consisting of an asymptotic giant branch (AGB) mass-losing star and an accreting companion. The presence of mass outflows is studied as a function of mass-loss rate, wind temperature, and binary orbital parameters. A two-dimensional hydrodynamical model is used to study the stability of mass transfer in wind accreting symbiotic binary systems. In our simulations we use an adiabatic equation of state and a modified version of the isothermal approximation, where the temperature depends on the distance from the mass losing star and its companion. The code uses a block-structured adaptive mesh refinement method that allows us to have high resolution at the position of the secondary and resolve the formation of bow shocks and accretion disks. We explore the accretion flow between the components and formation of accretion disks for a range of orbital separations and wind parameters. Our results show the formation of stream flow between the stars and accretion disks of various sizes for certain orbital configurations. For a typical slow and massive wind from an AGB star the flow pattern is similar to a Roche lobe overflow with accretion rates of 10% of the mass loss from the primary. Stable disks with exponentially decreasing density profiles and masses of the order 10-4 solar masses are formed when wind acceleration occurs at several stellar radii. The disks are geometrically thin with eccentric streamlines and close to Keplerian velocity profiles. The formation of tidal streams and accretion disks is found to be weakly dependent on

  16. NUMERICAL SIMULATIONS OF WIND ACCRETION IN SYMBIOTIC BINARIES

    International Nuclear Information System (INIS)

    De Val-Borro, M.; Karovska, M.; Sasselov, D.

    2009-01-01

    About half of the binary systems are close enough to each other for mass to be exchanged between them at some point in their evolution, yet the accretion mechanism in wind accreting binaries is not well understood. We study the dynamical effects of gravitational focusing by a binary companion on winds from late-type stars. In particular, we investigate the mass transfer and formation of accretion disks around the secondary in detached systems consisting of an asymptotic giant branch (AGB) mass-losing star and an accreting companion. The presence of mass outflows is studied as a function of mass-loss rate, wind temperature, and binary orbital parameters. A two-dimensional hydrodynamical model is used to study the stability of mass transfer in wind accreting symbiotic binary systems. In our simulations we use an adiabatic equation of state and a modified version of the isothermal approximation, where the temperature depends on the distance from the mass losing star and its companion. The code uses a block-structured adaptive mesh refinement method that allows us to have high resolution at the position of the secondary and resolve the formation of bow shocks and accretion disks. We explore the accretion flow between the components and formation of accretion disks for a range of orbital separations and wind parameters. Our results show the formation of stream flow between the stars and accretion disks of various sizes for certain orbital configurations. For a typical slow and massive wind from an AGB star the flow pattern is similar to a Roche lobe overflow with accretion rates of 10% of the mass loss from the primary. Stable disks with exponentially decreasing density profiles and masses of the order 10 -4 solar masses are formed when wind acceleration occurs at several stellar radii. The disks are geometrically thin with eccentric streamlines and close to Keplerian velocity profiles. The formation of tidal streams and accretion disks is found to be weakly dependent

  17. Resistance Exercise Impacts Lean Muscle Mass in Women with Polycystic Ovary Syndrome.

    Science.gov (United States)

    Kogure, Gislaine Satyko; Miranda-Furtado, Cristiana Libardi; Silva, Rafael Costa; Melo, Anderson Sanches; Ferriani, Rui Alberto; De Sá, Marcos Felipe Silva; Dos Reis, Rosana Maria

    2016-04-01

    This study investigated the effects of progressive resistance training (PRT) on lean muscle mass (LMM) in women with or without polycystic ovary syndrome (PCOS) and its effects on metabolic factors and concentrations of related steroid hormones. This was a nonrandomized, therapeutic, open, single-arm study. All in all, 45 sedentary women with PCOS and 52 without (non-PCOS), 18-37 yr of age, with body mass indexes (BMI) of 18-39.9 kg·m(-2) of all races and social status, performed PRT three times a week for 4 months. Before and after PRT, the concentrations of hormones and metabolic factors and waist circumference were measured. LMM and total body fat percentage were determined using dual-energy x-ray absorptiometry. Clinical characteristics, LMM, and fasting glucose were adjusted for confounding covariables and compared using general linear mixed models. Each patient's menstrual history was taken before study enrollment and after PRT. PRT resulted in reduced plasma testosterone and fasting glucose levels. After PRT, the androstenedione concentration increased and the sex hormone-binding globulin concentration decreased in women with PCOS. The waist circumference was reduced (P lean mass (LM)/height2, increased in women with PCOS (P = 0.04). Women with PCOS showed increased muscle mass indexes of appendicular LM/height2 (P = 0.03) and LM/height2 (P women with PCOS (P = 0.01) at the baseline and after PRT. To our knowledge, this is the first report to show that resistance exercise alone can improve hyperandrogenism, reproductive function, and body composition by decreasing visceral fat and increasing LMM, but it has no metabolic impact on women with PCOS.

  18. Is increase in bone mineral content caused by increase in skeletal muscle mass/strength in adult patients with GH-treated GH deficiency? A systematic literature analysis

    DEFF Research Database (Denmark)

    Klefter, O.; Feldt-Rasmussen, U.

    2009-01-01

    to a muscle modulating effect, and if treatment with GH would primarily increase muscle mass and strength with a secondary increase in BMD/BMC, thus supporting the present physiological concept that mass and strength of bones are mainly determined by dynamic loads from the skeletal muscles. METHOD: We...... performed a systematic literature analysis, including 51 clinical trials published between 1996 and 2008, which had studied the development in muscle mass, muscle strength, BMD, and/or BMC in GH-treated adult GHD patients. RESULTS: GH therapy had an anabolic effect on skeletal muscle. The largest increase...... in muscle mass occurred during the first 12 months of therapy. Most trials measuring BMD/BMC reported significant increases from baseline values. The significant increases in BMD/BMC occurred after 12-18 months of treatment, i.e. usually later than the increases in muscle parameters. Only seven trials...

  19. Is increase in bone mineral content caused by increase in skeletal muscle mass/strength in adult patients with GH-treated GH deficiency?

    DEFF Research Database (Denmark)

    Klefter, Oliver; Feldt-Rasmussen, Ulla

    2009-01-01

    to a muscle modulating effect, and if treatment with GH would primarily increase muscle mass and strength with a secondary increase in BMD/BMC, thus supporting the present physiological concept that mass and strength of bones are mainly determined by dynamic loads from the skeletal muscles. METHOD: We...... performed a systematic literature analysis, including 51 clinical trials published between 1996 and 2008, which had studied the development in muscle mass, muscle strength, BMD, and/or BMC in GH-treated adult GHD patients. RESULTS: GH therapy had an anabolic effect on skeletal muscle. The largest increase...... in muscle mass occurred during the first 12 months of therapy. Most trials measuring BMD/BMC reported significant increases from baseline values. The significant increases in BMD/BMC occurred after 12-18 months of treatment, i.e. usually later than the increases in muscle parameters. Only seven trials...

  20. A dietary supplementation with leucine and antioxidants is capable to accelerate muscle mass recovery after immobilization in adult rats.

    Directory of Open Access Journals (Sweden)

    Isabelle Savary-Auzeloux

    Full Text Available Prolonged inactivity induces muscle loss due to an activation of proteolysis and decreased protein synthesis; the latter is also involved in the recovery of muscle mass. The aim of the present work was to explore the evolution of muscle mass and protein metabolism during immobilization and recovery and assess the effect of a nutritional strategy for counteracting muscle loss and facilitating recovery. Adult rats (6-8 months were subjected to unilateral hindlimb casting for 8 days (I0-I8 and then permitted to recover for 10 to 40 days (R10-R40. They were fed a Control or Experimental diet supplemented with antioxidants/polyphenols (AOX (I0 to I8, AOX and leucine (AOX + LEU (I8 to R15 and LEU alone (R15 to R40. Muscle mass, absolute protein synthesis rate and proteasome activities were measured in gastrocnemius muscle in casted and non-casted legs in post prandial (PP and post absorptive (PA states at each time point. Immobilized gastrocnemius protein content was similarly reduced (-37% in both diets compared to the non-casted leg. Muscle mass recovery was accelerated by the AOX and LEU supplementation (+6% AOX+LEU vs. Control, P<0.05 at R40 due to a higher protein synthesis both in PA and PP states (+23% and 31% respectively, Experimental vs. Control diets, P<0.05, R40 without difference in trypsin- and chymotrypsin-like activities between diets. Thus, this nutritional supplementation accelerated the recovery of muscle mass via a stimulation of protein synthesis throughout the entire day (in the PP and PA states and could be a promising strategy to be tested during recovery from bed rest in humans.

  1. Relationship between lifting performance and skeletal muscle mass in elite powerlifters.

    Science.gov (United States)

    Ye, X; Loenneke, J P; Fahs, C A; Rossow, L M; Thiebaud, R S; Kim, D; Bemben, M G; Abe, T

    2013-08-01

    Aim of the study was to examine the relationship between whole body skeletal muscle mass (SMM) and powerlifting performance in elite powerlifters. Twenty elite male powerlifters, including 4 world champions, volunteered. Muscle thickness (MTH) and subcutaneous fat thickness (FTH) were measured by ultrasound at 9 sites on the anterior and posterior aspects of the body. FTH was used to estimate body fat and fat-free mass and SMM was estimated from ultrasound-derived prediction equations. Best lifting performance in the squat (SQ), bench press (BP), and dead lift (DL) was recorded from competition performance. Significant strong correlations (Pwide range of weight classes (56kg-145kg) and there were no significant correlation between the SMM and those performances (r=0.21 for SQ and r=0.12 for BP). However, the DL/SMM ratio was negatively correlated to DL performance (r=-0.47, P<0.05). SMM is a good predictor of powerlifting performance throughout all weight classes.

  2. Low appendicular skeletal muscle mass (ASM) with limited mobility and poor health outcomes in middle-aged African Americans.

    Science.gov (United States)

    Malmstrom, Theodore K; Miller, Douglas K; Herning, Margaret M; Morley, John E

    2013-09-01

    Recent efforts to provide a consensus definition propose that sarcopenia be considered a clinical syndrome associated with the loss of both skeletal muscle mass and muscle function that occurs with aging. Validation of sarcopenia definitions that include both low muscle mass and poor muscle function is needed. In the population-based African American Health (AAH) study (N = 998 at baseline/wave 1), muscle mass and mobility were evaluated in a clinical testing center in a subsample of N = 319 persons (ages 52-68) at wave 4 (2004). Muscle mass was measured using dual energy x-ray absorptiometry and mobility by a 6-min walk test and 4-m gait walk test. Height corrected appendicular skeletal mass (ASM; 9.0 ± 1.5 in n = 124 males, 8.3 ± 2.2 in n = 195 females) was computed as total lean muscle mass in arms and legs (kilograms) divided by the square of height (meters). Cross-sectional and longitudinal (6-year) associations of low ASM (bottom 25 % AAH sample; ASM with limited mobility (4-m gait walk ≤1 m/s or 6-min walk ASM with limited mobility was associated with IADL difficulties (p = .008) and frailty (p = .040) but not with ADL difficulties or falls in cross-sectional analyses; and with ADL difficulties (p = .022), IADL difficulties (p = .006), frailty (p = .039), and mortality (p = .003) but not with falls in longitudinal analyses adjusted for age and gender. Low ASM alone was marginally associated with mortality (p = .085) but not with other outcomes in cross-sectional or longitudinal analyses. Low ASM with limited mobility is associated with poor health outcomes among late middle-aged African Americans.

  3. Creatine monohydrate supplementation does not increase muscle strength, lean body mass, or muscle phosphocreatine in patients with myotonic dystrophy type 1.

    Science.gov (United States)

    Tarnopolsky, Mark; Mahoney, Douglas; Thompson, Terry; Naylor, Heather; Doherty, Timothy J

    2004-01-01

    Creatine monohydrate (CrM) supplementation may increase strength in some types of muscular dystrophy. A recent study in myotonic muscular dystrophy type 1 (DM1) did not find a significant treatment effect, but measurements of muscle phosphocreatine (PCr) were not performed. We completed a randomized, double-blind, cross-over trial using 34 genetically confirmed adult DM1 patients without significant cognitive impairment. Participants received CrM (5 g, approximately 0.074 g/kg daily) and a placebo for each 4-month phase with a 6-week wash-out. Spirometry, manual muscle testing, quantitative isometric strength testing of handgrip, foot dorsiflexion, and knee extension, handgrip and foot dorsiflexion endurance, functional tasks, activity of daily living scales, body composition (total, bone, and fat-free mass), serum creatine kinase activity, serum creatinine concentration and clearance, and liver function tests were completed before and after each intervention, and muscle PCr/beta-adenosine triphosphate (ATP) ratios of the forearm flexor muscles were completed at the end of each phase. CrM supplementation did not increase any of the outcome measurements except for plasma creatinine concentration (but not creatinine clearance). Thus, CrM supplementation at 5 g daily does not have any effects on muscle strength, body composition, or activities of daily living in patients with DM1, perhaps because of a failure of the supplementation to increase muscle PCr/beta-ATP content.

  4. Genes Whose Gain or Loss-Of-Function Increases Skeletal Muscle Mass in Mice: A Systematic Literature Review

    Directory of Open Access Journals (Sweden)

    Sander A. J. Verbrugge

    2018-05-01

    Full Text Available Skeletal muscle mass differs greatly in mice and humans and this is partially inherited. To identify muscle hypertrophy candidate genes we conducted a systematic review to identify genes whose experimental loss or gain-of-function results in significant skeletal muscle hypertrophy in mice. We found 47 genes that meet our search criteria and cause muscle hypertrophy after gene manipulation. They are from high to small effect size: Ski, Fst, Acvr2b, Akt1, Mstn, Klf10, Rheb, Igf1, Pappa, Ppard, Ikbkb, Fstl3, Atgr1a, Ucn3, Mcu, Junb, Ncor1, Gprasp1, Grb10, Mmp9, Dgkz, Ppargc1a (specifically the Ppargc1a4 isoform, Smad4, Ltbp4, Bmpr1a, Crtc2, Xiap, Dgat1, Thra, Adrb2, Asb15, Cast, Eif2b5, Bdkrb2, Tpt1, Nr3c1, Nr4a1, Gnas, Pld1, Crym, Camkk1, Yap1, Inhba, Tp53inp2, Inhbb, Nol3, Esr1. Knock out, knock down, overexpression or a higher activity of these genes causes overall muscle hypertrophy as measured by an increased muscle weight or cross sectional area. The mean effect sizes range from 5 to 345% depending on the manipulated gene as well as the muscle size variable and muscle investigated. Bioinformatical analyses reveal that Asb15, Klf10, Tpt1 are most highly expressed hypertrophy genes in human skeletal muscle when compared to other tissues. Many of the muscle hypertrophy-regulating genes are involved in transcription and ubiquitination. Especially genes belonging to three signaling pathways are able to induce hypertrophy: (a Igf1-Akt-mTOR pathway, (b myostatin-Smad signaling, and (c the angiotensin-bradykinin signaling pathway. The expression of several muscle hypertrophy-inducing genes and the phosphorylation of their protein products changes after human resistance and high intensity exercise, in maximally stimulated mouse muscle or in overloaded mouse plantaris.

  5. Relation between body mass index percentile and muscle strength and endurance

    Directory of Open Access Journals (Sweden)

    Noha Abdel Kader Abdel Kader Hasan

    2016-10-01

    Conclusion: The study shows that the BMI of children had a positive correlation with the muscle strength of quadriceps, triceps, and abdominal muscles while a negative correlation with the endurance time of these muscles.

  6. Prognostic significance of low skeletal muscle mass compared with protein-energy malnutrition in liver cirrhosis.

    Science.gov (United States)

    Nishikawa, Hiroki; Enomoto, Hirayuki; Ishii, Akio; Iwata, Yoshinori; Miyamoto, Yuho; Ishii, Noriko; Yuri, Yukihisa; Takata, Ryo; Hasegawa, Kunihiro; Nakano, Chikage; Nishimura, Takashi; Yoh, Kazunori; Aizawa, Nobuhiro; Sakai, Yoshiyuki; Ikeda, Naoto; Takashima, Tomoyuki; Iijima, Hiroko; Nishiguchi, Shuhei

    2017-09-01

    To investigate the impact of low skeletal muscle mass (LSMM) on survival as compared with protein-energy malnutrition (PEM) in patients with liver cirrhosis (LC). A total of 206 individuals with LC were analyzed. We retrospectively examined the impact of LSMM, as defined by psoas muscle mass at the third lumber on computed tomography, on survival as compared with PEM. In terms of comparison of the effects of LSMM and PEM on survival, we used time-dependent receiver operating characteristics (ROC) analysis. Our study cohort included 115 men and 91 women with a median age of 67 years. There were 140 patients with Child-Pugh A, 62 with Child-Pugh B, and 4 with Child-Pugh C. A total of 117 patients (56.8%) had LSMM and 52 patients (25.2%) had PEM. The proportion of PEM in patients with LSMM (31.62%, 37/117) was significantly higher than in patients without LSMM (16.85%, 15/89) (P = 0.0229). In the multivariate analysis for the entire cohort, the presence of hepatocellular carcinoma, lower body mass index, presence of LSMM, lower triglyceride value, poorer renal function, and higher des-γ-carboxy prothrombin value were found to be significant adverse predictors linked to overall survival, while presence of PEM tended to be significant. In the time-dependent ROC analysis, all area under the ROCs for survival in LSMM at each time point were higher than those in PEM except for Child-Pugh B patients. In this comparison of LSMM and PEM on clinical outcomes in LC patients, it was shown that LSMM may have stronger prognostic impact than PEM. © 2016 The Japan Society of Hepatology.

  7. The Effect of a 12-Week Omega-3 Supplementation on Body Composition, Muscle Strength and Physical Performance in Elderly Individuals with Decreased Muscle Mass

    Directory of Open Access Journals (Sweden)

    Roma Krzymińska-Siemaszko

    2015-08-01

    Full Text Available The aim of the study was to assess the effect of a polyunsaturated omega-3 fatty acids (PUFA supplementation on the parameters of body composition, muscle strength and physical performance in elderly people with decreased muscle mass (DMM. Fifty three elderly people with an ALM index (the ratio of appendicular lean mass to squared height either below (−2SD: low muscle mass-LMM or between (−1SD and −2SD: the risk of LMM-rLMM the ALM index for the young Polish reference population were randomly assigned to PUFA-treated groups (LMM-PUFA, rLMM-PUFA or control groups (LMM-control, rLMM-control. PUFA-treated groups received capsules containing 1.3 g of PUFA and 10 mg of vitamin E, while the control groups received 11 mg of vitamin E daily for 12 weeks. Body composition (BIA analysis, muscle strength (hand grip measured with dynamometer and physical performance (Timed Up and Go test-TUG were assessed before and after supplementation. No statistically significant differences were observed either in muscle mass or in the hand grip and TUG in any group. The post-pre difference (mean ± SD in ALM index was as follows (kg/m2: LMM-PUFA: 0.00 ± 0.30, rLMM-PUFA: 0.00 ± 0.22, LMM-control: 0.03 ± 0.36, rLMM-control: –0.03 ± 0.20. In our study, a 12 week supplementation of PUFA did not affect the evaluated parameters in elderly individuals with DMM.

  8. Associations between lower extremity muscle mass and metabolic parameters related to obesity in Japanese obese patients with type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Hidetaka Hamasaki

    2015-05-01

    Full Text Available Background. Age-related loss of muscle mass (sarcopenia increases the incidence of obesity in the elderly by reducing physical activity. This sarcopenic obesity may become self-perpetuating, increasing the risks for metabolic syndrome, disability, and mortality. We investigated the associations of two sarcopenic indices, the ratio of lower extremity muscle mass to body weight (L/W ratio and the ratio of lower extremity muscle mass to upper extremity muscle mass (L/U ratio, with metabolic parameters related to obesity in patients with type 2 diabetes and obesity.Methods. Of 148 inpatients with type 2 diabetes treated between October 2013 and April 2014, we recruited 26 with obesity but no physical disability. Daily physical activity was measured by a triaxial accelerometer during a period of hospitalization, and which was also evaluated by our previously reported non-exercise activity thermogenesis questionnaire. We measured body composition by bioelectrical impedance and investigated the correlations of L/W and L/U ratios with body weight, body mass index (BMI, waist circumference (WC, waist-to-hip ratio (WHR, visceral fat area, subcutaneous fat area, serum lipid profile, and daily physical activity.Results. The L/W ratio was significantly and negatively correlated with BMI, WC, WHR, body fat mass, body fat percentage, subcutaneous fat area, and serum free fatty acid concentration, was positively correlated with daily physical activity: the locomotive non-exercise activity thermogenesis score, but was not correlated with visceral fat area. The L/U ratio was significantly and positively correlated with serum high-density lipoprotein cholesterol.Conclusions. High L/W and L/U ratios, indicative of relatively preserved lower extremity muscle mass, were predictive of improved metabolic parameters related to obesity. Preserved muscle fitness in obesity, especially of the lower extremities, may prevent sarcopenic obesity and lower associated risks for

  9. Bondi-Hoyle-Lyttleton Accretion onto Binaries

    Science.gov (United States)

    Antoni, Andrea; MacLeod, Morgan; Ramírez-Ruiz, Enrico

    2018-01-01

    Binary stars are not rare. While only close binary stars will eventually interact with one another, even the widest binary systems interact with their gaseous surroundings. The rates of accretion and the gaseous drag forces arising in these interactions are the key to understanding how these systems evolve. This poster examines accretion flows around a binary system moving supersonically through a background gas. We perform three-dimensional hydrodynamic simulations of Bondi-Hoyle-Lyttleton accretion using the adaptive mesh refinement code FLASH. We simulate a range of values of semi-major axis of the orbit relative to the gravitational focusing impact parameter of the pair. On large scales, gas is gravitationally focused by the center-of-mass of the binary, leading to dynamical friction drag and to the accretion of mass and momentum. On smaller scales, the orbital motion imprints itself on the gas. Notably, the magnitude and direction of the forces acting on the binary inherit this orbital dependence. The long-term evolution of the binary is determined by the timescales for accretion, slow down of the center-of-mass, and decay of the orbit. We use our simulations to measure these timescales and to establish a hierarchy between them. In general, our simulations indicate that binaries moving through gaseous media will slow down before the orbit decays.

  10. Low skeletal muscle mass outperforms the Charlson Comorbidity Index in risk prediction in patients undergoing pancreatic resections.

    Science.gov (United States)

    Wagner, D; Marsoner, K; Tomberger, A; Haybaeck, J; Haas, J; Werkgartner, G; Cerwenka, H; Bacher, H; Mischinger, H J; Kornprat, P

    2018-05-01

    Low skeletal muscle mass is a known predictor of morbidity and mortality in patients undergoing major pancreatic surgeries. We sought to combine low skeletal muscle mass with established risk predictors to improve their prognostic capacity for postoperative outcome and morbidity. As established parameters to predict preoperative mortality risk for patients, the ASA classification and the Charlson Comorbidity Index (CCI) were used. The Hounsfield Units Average Calculation (HUAC) was measured to define low skeletal muscle mass in 424 patients undergoing pancreatic resections for malignancies. Patients in the lowest sex-adjusted quartile for HUAC were defined as having low skeletal muscle mass (muscle wasting). Multivariable Cox regression analysis was utilized to identify preoperative risk factors associated with postoperative morbidity. Median patient age was 63 years (19-87), 47.9% patients were male, and half the cohort had multiple comorbidities (Charlson Comorbidity Index [CCI]>6, 63.2%), 30-day mortality was 5.8% (n = 25). Median HUAC was 19.78 HU (IQR: 15.94-23.54) with 145 patients (34.2%) having low skeletal muscle mass. Preoperative frailty defined by low skeletal muscle mass was associated with an increased risk for postoperative complications (OR 1.55, CI 95% 0.98-2.45, p = 0.014), and a higher 30-day mortality (HR 5.17, CI 95% 1.57-16.69, p = 0.004). With an AUC of 0.85 HUAC showed the highest predictability for 30-day mortality (CI 95% 0.78-0.91, p = 0.0001). Patients with CCI ≥6 and low skeletal muscle mass defined by the HUAC had a 9.78 higher risk of dying in the immediate postoperative phase (HR 9.78, CI 95% 2.98-12.2, p = 0.0001). Low skeletal muscle mass predicts postoperative mortality and complications best and it should be incorporated to conventional risk scores to identify high risk patients. Copyright © 2018 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights

  11. Effects of progressive strength training on muscle mass in type 2 diabetes mellitus patients determined by computed tomography

    International Nuclear Information System (INIS)

    Cauza, E.; Strehblow, C.; Hanusch-Enserer, U.; Fasching, P.; Metz-Schimmerl, S.; Strasser, B.; Kostner, K.; Dunstan, D.; Haber, P.

    2009-01-01

    To examine the effect of a 4-month progressive strength training program on muscle and fat mass assessed by computed tomography (CT) in type 2 diabetes mellitus (T2DM) patients, and to assess the relationships of changes in muscle cross-section area (CSA) with glycaemic control. Twenty adults (mean age ± SE: 56.4 ± 0.9 a) with T2DM participated in a supervised strength training program for 4 months 3 days/week. Muscle and fat areas of the quadriceps muscle were estimated by CT volumetry before and immediately after the training. Glycaemic (HbA1c) and anthropometric (BMI, skinfolds) measurements were assessed at 0 and 4 months, respectively. After strength training, muscle strength increased significantly in all measured muscle groups. Quadriceps size (CSA of the muscle) was increased by 2.4 % (from 7.99 ± 0.3 cm 3 to 8.18 ± 0.3 cm 3 , p = 0.003) for the right extremity, 3.9 % (from 8.1 ± 0.4 cm 3 to 8.41 ± 0.5 cm 3 , p = 0.04) for the left side. Fat tissue CSA reduced from 0.66 ± 0.1 cm 3 to 0.56 ± 0.12 cm 3 for the right leg (15.3 % reduction) and from 0.58 ± 0.12 cm 3 to 0.37 ± 0.13 cm 3 for the left leg (35.8 % reduction), resulting in a mean fat CSA reduction of 24.8 %. Fat mass assessed by skin folds was significantly reduced and lean body mass was significantly increased. The change in muscle CSA was not correlated with the changes in HbA1c or muscle strength. Strength training significantly improves both muscle mass and the muscle to fat ratio in T2DM. However, changes in muscle observed with computed tomography were not related to changes observed in HbA1c with training. (author) [de

  12. Usefulness of circuit training at home for improving bone mass and muscle mass while losing fat mass in undergraduate female students.

    Science.gov (United States)

    Takahata, Yoko

    2018-05-09

    The purpose of this study was to determine whether or not circuit training at home affects the calcaneus quantitative ultrasound status as well as other indices of body composition among undergraduate female students. Forty-one adolescents were recruited (18.5 ± 0.6 years old). The stiffness index of the calcaneus, broadband ultrasound attenuation of the calcaneus, speed of sound of the calcaneus, and body frame index. This was a three-month intervention study, so the measurements were conducted at baseline, 2 months later, and 3 months later while the subjects underwent circuit training at home. The subjects were divided into two groups: namely, the exercising group and non-exercising group. In the exercising group, broadband ultrasound attenuation of the calcaneus was higher 2 months later (p = 0.033) as well as 3 months later (p = 0.036), and the speed of sound of the calcaneus was higher 3 months later (p = 0.018). In addition, the muscle mass was strongly positively correlated with the calcaneus QUS-SOS (p = 0.004), while the body fat percentage was a strongly negatively correlated with the calcaneus QUS-BUA (p = 0.043). In the non-exercising group, the stiffness index of the calcaneus was higher 2 months later (p = 0.002) as well as 3 months later (p = 0.002). Furthermore, the body percentage was strongly positively correlated with the calcaneus QUS-SI (p = 0.009). These findings suggest that the calcaneus quantitative ultrasound status and muscle mass while losing fat mass may be improved by means of a simple exercise regimen within a short period among undergraduate female students.

  13. Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence.

    Science.gov (United States)

    Tezze, Caterina; Romanello, Vanina; Desbats, Maria Andrea; Fadini, Gian Paolo; Albiero, Mattia; Favaro, Giulia; Ciciliot, Stefano; Soriano, Maria Eugenia; Morbidoni, Valeria; Cerqua, Cristina; Loefler, Stefan; Kern, Helmut; Franceschi, Claudio; Salvioli, Stefano; Conte, Maria; Blaauw, Bert; Zampieri, Sandra; Salviati, Leonardo; Scorrano, Luca; Sandri, Marco

    2017-06-06

    Mitochondrial dysfunction occurs during aging, but its impact on tissue senescence is unknown. Here, we find that sedentary but not active humans display an age-related decline in the mitochondrial protein, optic atrophy 1 (OPA1), that is associated with muscle loss. In adult mice, acute, muscle-specific deletion of Opa1 induces a precocious senescence phenotype and premature death. Conditional and inducible Opa1 deletion alters mitochondrial morphology and function but not DNA content. Mechanistically, the ablation of Opa1 leads to ER stress, which signals via the unfolded protein response (UPR) and FoxOs, inducing a catabolic program of muscle loss and systemic aging. Pharmacological inhibition of ER stress or muscle-specific deletion of FGF21 compensates for the loss of Opa1, restoring a normal metabolic state and preventing muscle atrophy and premature death. Thus, mitochondrial dysfunction in the muscle can trigger a cascade of signaling initiated at the ER that systemically affects general metabolism and aging. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  14. Ratio of muscle mass to fat mass assessed by bioelectrical impedance analysis is significantly correlated with liver fat accumulation in patients with type 2 diabetes mellitus.

    Science.gov (United States)

    Kurinami, Noboru; Sugiyama, Seigo; Morita, Ayami; Yoshida, Akira; Hieshima, Kunio; Miyamoto, Fumio; Kajiwara, Keizo; Jinnouch, Katsunori; Jinnouchi, Tomio; Jinnouchi, Hideaki

    2018-05-01

    Obesity and ectopic fat accumulation are important conditions of type 2 diabetes mellitus (T2DM). Our aim was to determine whether bioelectrical impedance body composition analysis combined with blood test results could estimate liver ectopic fat accumulation in patients with treatment-naïve T2DM. Subjects were 119 untreated T2DM patients. Computed tomography scans were performed to calculate the liver to spleen attenuation ratio (L/S ratio) as a measure of liver fat accumulation, with excess liver fat accumulation defined as an L/S ratio analysis using InBody770. The Nagelkerke R 2 test showed that the muscle mass/fat mass ratio (muscle/fat ratio) was the most suitable variable among anthropometric factors and body component indexes for estimating liver fat accumulation. The muscle/fat ratio was significantly correlated with the L/S ratio (ρ = 0.4386, P analysis showed that the muscle/fat ratio (odds ratio 0.40, 95% confidence interval 0.22-0.73, P ratio 1.06, 95% confidence interval 1.02-1.10, P analysis, the cutoff value of the muscle/fat ratio for excess liver fat accumulation was 2.34. In patients with treatment-naïve T2DM, the muscle/fat ratio and ALT are useful for estimating the presence of excess liver fat accumulation in daily clinical practice. Copyright © 2018. Published by Elsevier B.V.

  15. Imaging mass spectrometry reveals fiber-specific distribution of acetylcarnitine and contraction-induced carnitine dynamics in rat skeletal muscles.

    Science.gov (United States)

    Furuichi, Yasuro; Goto-Inoue, Naoko; Manabe, Yasuko; Setou, Mitsutoshi; Masuda, Kazumi; Fujii, Nobuharu L

    2014-10-01

    Carnitine is well recognized as a key regulator of long-chain fatty acyl group translocation into the mitochondria. In addition, carnitine, as acetylcarnitine, acts as an acceptor of excess acetyl-CoA, a potent inhibitor of pyruvate dehydrogenase. Here, we provide a new methodology for accurate quantification of acetylcarnitine content and determination of its localization in skeletal muscles. We used matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) to visualize acetylcarnitine distribution in rat skeletal muscles. MALDI-IMS and immunohistochemistry of serial cross-sections showed that acetylcarnitine was enriched in the slow-type muscle fibers. The concentration of ATP was lower in muscle regions with abundant acetylcarnitine, suggesting a relationship between acetylcarnitine and metabolic activity. Using our novel method, we detected an increase in acetylcarnitine content after muscle contraction. Importantly, this increase was not detected using traditional biochemical assays of homogenized muscles. We also demonstrated that acetylation of carnitine during muscle contraction was concomitant with glycogen depletion. Our methodology would be useful for the quantification of acetylcarnitine and its contraction-induced kinetics in skeletal muscles. Copyright © 2014 Elsevier B.V. All rights reserved.

  16. Effects of exercise improves muscle strength and fat mass in patients with high fracture risk: A randomized control trial

    Directory of Open Access Journals (Sweden)

    Ding-Cheng Chan

    2018-07-01

    Full Text Available Background: The deterioration of the musculoskeletal system imposes significant impact on physical activity. Exercise is an important strategy which minimizes these changes. It is not clear which type of exercise provides better improvement on low physical performance, low muscle mass and low strength of sarcopenia. We aim to develop an integrated care (IC model and compare its relative efficacy in limb fat free mass, muscle strength, and physical performance with low extremities exercise (LEE in community dwelling older adults with high risk of fractures (Fracture Risk Assessment Tool (FRAX® ≧3% for hip fracture, ≧20% for major osteoporotic fracture or 1-min osteoporosis risk test (≧1 point or fall (≧2 falls in previous year. Methods: Patients were assigned randomized to participate in either IC or LEE group (n = 55 each for 3 months. All participants received education including home-based exercise. The IC group consisted of different modalities of exercise while the LEE group performed machine-based low extremities exercise. Fat free mass, muscle strength, and physical performance were measured at their baseline and 3-months follow-up. Results: Mean age was 73.8 ± 7 years with 69.1% women. Entire cohort demonstrated significant increment in fat free mass, muscle strength (4 indicators and physical performance (3 indicators. However, between group differences were not significant. Conclusion: With regular supervise exercise; both groups are equally effective in decreasing fat mass and increasing physical performance, muscle mass and strength. However, the IC group required fewer resources and thus more financially feasible in a community setting. Keywords: Bone mineral density, Gender differences, Integrated care, Low extremities exercise, Muscle strength

  17. Polymorphisms of muscle genes are associated with bone mass and incident osteoporotic fractures in Caucasians

    DEFF Research Database (Denmark)

    Harsløf, Torben; Frost, M; Nielsen, T L

    2013-01-01

    The interaction between muscle and bone is complex. The aim of this study was to investigate if variations in the muscle genes myostatin (MSTN), its receptor (ACVR2B), myogenin (MYOG), and myoD1 (MYOD1) were associated with fracture risk, bone mineral density (BMD), bone mineral content (BMC......), and lean body mass. We analyzed two independent cohorts: the Danish Osteoporosis Prevention Study (DOPS), comprising 2,016 perimenopausal women treated with hormone therapy or not and followed for 10 years, and the Odense Androgen Study (OAS), a cross-sectional, population-based study on 783 men aged 20......-29 years. Nine tag SNPs in the four genes were investigated. In the DOPS, individuals homozygous for the variant allele of the MSTN SNP rs7570532 had an increased risk of any osteoporotic fracture, with an HR of 1.82 (95 % CI 1.15-2.90, p = 0.01), and of nonvertebral osteoporotic fracture, with an HR of 2...

  18. Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes

    DEFF Research Database (Denmark)

    Pedersen, Maria; Bruunsgaard, Helle; Weis, Nina

    2003-01-01

    The purpose of the current study was to test the hypothesis that an altered fat distribution in elderly healthy subjects and in patients with type-2 diabetes contributes to high circulating levels of interleukin (IL)-6 and tumor necrotic factor (TNF)-alpha, which secondly is related to lower muscle...... mass. Twenty young controls, (20-35 yr), 20 healthy elderly subjects (65-80 yr) and 16 elderly patients with type 2 diabetes (65-80 yr) were included in a cross sectional study. Plasma levels of TNF-alpha and IL-6 were measured after an overnight fast. Dual-energy X-ray absorptiometry and total body...... potassium counting measured truncal fat, appendicular skeletal muscle mass (ASM) and body cell mass (BCM), respectively. TNF-alpha, IL-6 and the relative truncal fat mass were higher in elderly compared with young controls. ASM was lower in diabetic men than in young controls and BCM was lower in elderly...

  19. Testosterone therapy increased muscle mass and lipid oxidation in aging men

    DEFF Research Database (Denmark)

    Frederiksen, Louise; Højlund, Kurt; Hougaard, David M

    2011-01-01

    The indication for testosterone therapy in aging hypogonadal men without hypothalamic, pituitary, or testicular disease remains to be elucidated. The aim of this study was to investigate the effect of testosterone therapy on insulin sensitivity, substrate metabolism, body composition, and lipids...... lipid oxidation (b = 5.65 mg/min/m(2), p = 0.045) increased and basal glucose oxidation (b = -9.71 mg/min/m(2), p = 0.046) decreased in response to testosterone therapy even when corrected for changes in LBM. No significant changes in insulin-stimulated Rd was observed (b = -0.01mg/min/m(2), p = 0.......92). Testosterone therapy increased muscle mass and lipid oxidation in aging men with low normal bioavailable testosterone levels; however, our data did not support an effect of testosterone on whole-body insulin sensitivity using the euglycemic hyperinsulinemic clamp technique....

  20. Accretion and evaporation of modified Hayward black hole

    International Nuclear Information System (INIS)

    Debnath, Ujjal

    2015-01-01

    We assume the most general static spherically symmetric black hole metric. The accretion of any general kind of fluid flow around the black hole is investigated. The accretion of the fluid flow around the modified Hayward black hole is analyzed, and we then calculate the critical point, the fluid's four-velocity, and the velocity of sound during the accretion process. Also the nature of the dynamical mass of the black hole during accretion of the fluid flow, taking into consideration Hawking radiation from the black hole, i.e., evaporation of the black hole, is analyzed. (orig.)

  1. Accretion onto a charged higher-dimensional black hole

    International Nuclear Information System (INIS)

    Sharif, M.; Iftikhar, Sehrish

    2016-01-01

    This paper deals with the steady-state polytropic fluid accretion onto a higher-dimensional Reissner-Nordstroem black hole. We formulate the generalized mass flux conservation equation, energy flux conservation and relativistic Bernoulli equation to discuss the accretion process. The critical accretion is investigated by finding the critical radius, the critical sound velocity, and the critical flow velocity. We also explore gas compression and temperature profiles to analyze the asymptotic behavior. It is found that the results for the Schwarzschild black hole are recovered when q = 0 in four dimensions. We conclude that the accretion process in higher dimensions becomes slower in the presence of charge. (orig.)

  2. Accretion onto a charged higher-dimensional black hole

    Energy Technology Data Exchange (ETDEWEB)

    Sharif, M.; Iftikhar, Sehrish [University of the Punjab, Department of Mathematics, Lahore (Pakistan)

    2016-03-15

    This paper deals with the steady-state polytropic fluid accretion onto a higher-dimensional Reissner-Nordstroem black hole. We formulate the generalized mass flux conservation equation, energy flux conservation and relativistic Bernoulli equation to discuss the accretion process. The critical accretion is investigated by finding the critical radius, the critical sound velocity, and the critical flow velocity. We also explore gas compression and temperature profiles to analyze the asymptotic behavior. It is found that the results for the Schwarzschild black hole are recovered when q = 0 in four dimensions. We conclude that the accretion process in higher dimensions becomes slower in the presence of charge. (orig.)

  3. SUPERNOVA LIGHT CURVES POWERED BY FALLBACK ACCRETION

    Energy Technology Data Exchange (ETDEWEB)

    Dexter, Jason; Kasen, Daniel, E-mail: jdexter@berkeley.edu [Departments of Physics and Astronomy, University of California, Berkeley, CA 94720 (United States)

    2013-07-20

    Some fraction of the material ejected in a core collapse supernova explosion may remain bound to the compact remnant, and eventually turn around and fall back. We show that the late time ({approx}>days) power potentially associated with the accretion of this 'fallback' material could significantly affect the optical light curve, in some cases producing super-luminous or otherwise peculiar supernovae. We use spherically symmetric hydrodynamical models to estimate the accretion rate at late times for a range of progenitor masses and radii and explosion energies. The accretion rate onto the proto-neutron star or black hole decreases as M-dot {proportional_to}t{sup -5/3} at late times, but its normalization can be significantly enhanced at low explosion energies, in very massive stars, or if a strong reverse shock wave forms at the helium/hydrogen interface in the progenitor. If the resulting super-Eddington accretion drives an outflow which thermalizes in the outgoing ejecta, the supernova debris will be re-energized at a time when photons can diffuse out efficiently. The resulting light curves are different and more diverse than previous fallback supernova models which ignored the input of accretion power and produced short-lived, dim transients. The possible outcomes when fallback accretion power is significant include super-luminous ({approx}> 10{sup 44} erg s{sup -1}) Type II events of both short and long durations, as well as luminous Type I events from compact stars that may have experienced significant mass loss. Accretion power may unbind the remaining infalling material, causing a sudden decrease in the brightness of some long duration Type II events. This scenario may be relevant for explaining some of the recently discovered classes of peculiar and rare supernovae.

  4. Muscle quality, aerobic fitness and fat mass predict lower-extremity physical function in community-dwelling older adults.

    Science.gov (United States)

    Misic, Mark M; Rosengren, Karl S; Woods, Jeffrey A; Evans, Ellen M

    2007-01-01

    Muscle mass, strength and fitness play a role in lower-extremity physical function (LEPF) in older adults; however, the relationships remain inadequately characterized. This study aimed to examine the relationships between leg mineral free lean mass (MFLM(LEG)), leg muscle quality (leg strength normalized for MFLM(LEG)), adiposity, aerobic fitness and LEPF in community-dwelling healthy elderly subjects. Fifty-five older adults (69.3 +/- 5.5 years, 36 females, 19 males) were assessed for leg strength using an isokinetic dynamometer, body composition by dual energy X-ray absorptiometry and aerobic fitness via a treadmill maximal oxygen consumption test. LEPF was assessed using computerized dynamic posturography and stair ascent/descent, a timed up-and-go task and a 7-meter walk with and without an obstacle. Muscle strength, muscle quality and aerobic fitness were similarly correlated with static LEPF tests (r range 0.27-0.40, p < 0.05); however, the strength of the independent predictors was not robust with explained variance ranging from 9 to 16%. Muscle quality was the strongest correlate of all dynamic LEPF tests (r range 0.54-0.65, p < 0.001). Using stepwise linear regression analysis, muscle quality was the strongest independent predictor of dynamic physical function explaining 29-42% of the variance (p < 0.001), whereas aerobic fitness or body fat mass explained 5-6% of the variance (p < 0.05) depending on performance measure. Muscle quality is the most important predictor, and aerobic fitness and fat mass are secondary predictors of LEPF in community-dwelling older adults. These findings support the importance of exercise, especially strength training, for optimal body composition, and maintenance of strength and physical function in older adults.

  5. The role of mTOR signaling in the regulation of protein synthesis and muscle mass during immobilization in mice

    Science.gov (United States)

    You, Jae-Sung; Anderson, Garrett B.; Dooley, Matthew S.; Hornberger, Troy A.

    2015-01-01

    ABSTRACT The maintenance of skeletal muscle mass contributes substantially to health and to issues associated with the quality of life. It has been well recognized that skeletal muscle mass is regulated by mechanically induced changes in protein synthesis, and that signaling by mTOR is necessary for an increase in protein synthesis and the hypertrophy that occurs in response to increased mechanical loading. However, the role of mTOR signaling in the regulation of protein synthesis and muscle mass during decreased mechanical loading remains largely undefined. In order to define the role of mTOR signaling, we employed a mouse model of hindlimb immobilization along with pharmacological, mechanical and genetic means to modulate mTOR signaling. The results first showed that immobilization induced a decrease in the global rates of protein synthesis and muscle mass. Interestingly, immobilization also induced an increase in mTOR signaling, eIF4F complex formation and cap-dependent translation. Blocking mTOR signaling during immobilization with rapamycin not only impaired the increase in eIF4F complex formation, but also augmented the decreases in global protein synthesis and muscle mass. On the other hand, stimulating immobilized muscles with isometric contractions enhanced mTOR signaling and rescued the immobilization-induced decrease in global protein synthesis through a rapamycin-sensitive mechanism that was independent of ribosome biogenesis. Unexpectedly, the effects of isometric contractions were also independent of eIF4F complex formation. Similar to isometric contractions, overexpression of Rheb in immobilized muscles enhanced mTOR signaling, cap-dependent translation and global protein synthesis, and prevented the reduction in fiber size. Therefore, we conclude that the activation of mTOR signaling is both necessary and sufficient to alleviate the decreases in protein synthesis and muscle mass that occur during immobilization. Furthermore, these results indicate

  6. Theories of magnetospheres around accreting compact objects

    International Nuclear Information System (INIS)

    Vasyliunas, V.M.

    1979-01-01

    A wide class of galactic X-ray sources are believed to be binary systems where mass is flowing from a normal star to a companion that is a compact object, such as a neutron star. The strong magnetic fields of the compact object create a magnetosphere around it. We review the theoretical models developed to describe the properties of magnetospheres in such accreting binary systems. The size of the magnetosphere can be estimated from pressure balance arguments and is found to be small compared to the over-all size of the accretion region but large compared object if the latter is a neutron star. In the early models the magnetosphere was assumed to have open funnels in the polar regions, through which accreting plasma could pour in. Later, magnetically closed models were developed, with plasma entry made possible by instabilities at the magnetosphere boundary. The theory of plasma flow inside the magnetosphere has been formulated in analogy to a stellar wind with reversed flow; a complicating factor is the instability of the Alfven critical point for inflow. In the case of accretion via a well-defined disk, new problems if magnetospheric structure appear, in particular the question to what extent and by what process the magnetic fields from the compact object can penetrate into the acretion disk. Since the X-ray emission is powered by the gravitational energy released in the accretion process, mass transfer into the magnetosphere is of fundamental importance; the various proposed mechanisms are critically examined. (orig.)

  7. Magnetohydrodynamics of accretion disks

    International Nuclear Information System (INIS)

    Torkelsson, U.

    1994-04-01

    The thesis consists of an introduction and summary, and five research papers. The introduction and summary provides the background in accretion disk physics and magnetohydrodynamics. The research papers describe numerical studies of magnetohydrodynamical processes in accretion disks. Paper 1 is a one-dimensional study of the effect of magnetic buoyancy on a flux tube in an accretion disk. The stabilizing influence of an accretion disk corona on the flux tube is demonstrated. Paper 2-4 present numerical simulations of mean-field dynamos in accretion disks. Paper 11 verifies the correctness of the numerical code by comparing linear models to previous work by other groups. The results are also extended to somewhat modified disk models. A transition from an oscillatory mode of negative parity for thick disks to a steady mode of even parity for thin disks is found. Preliminary results for nonlinear dynamos at very high dynamo numbers are also presented. Paper 3 describes the bifurcation behaviour of the nonlinear dynamos. For positive dynamo numbers it is found that the initial steady solution is replaced by an oscillatory solution of odd parity. For negative dynamo numbers the solution becomes chaotic at sufficiently high dynamo numbers. Paper 4 continues the studies of nonlinear dynamos, and it is demonstrated that a chaotic solution appears even for positive dynamo numbers, but that it returns to a steady solution of mixed parity at very high dynamo numbers. Paper 5 describes a first attempt at simulating the small-scale turbulence of an accretion disk in three dimensions. There is only find cases of decaying turbulence, but this is rather due to limitations of the simulations than that turbulence is really absent in accretion disks

  8. The Role of Muscle Mass, Muscle Quality, and Body Composition in Risk for the Metabolic Syndrome and Functional Decline in Older Adults: Topical Collection on Nutrition, Obesity, and Diabetes

    NARCIS (Netherlands)

    R.T. Mankowski (Robert T.); S.D. Anton (Stephen D.); M. Aubertin-Leheudre (Mylene)

    2015-01-01

    textabstractAbstract Age-related body composition changes include both loss of muscle mass (sarcopenia) and increase in fat mass, which jointly contribute to a decline in metabolic functions. Muscle quality is positively related to functional capacity and a lower risk for the development of the

  9. Normal Weight but Low Muscle Mass and Abdominally Obese: Implications for the Cardiometabolic Risk Profile in Chronic Obstructive Pulmonary Disease.

    Science.gov (United States)

    Beijers, Rosanne J H C G; van de Bool, Coby; van den Borst, Bram; Franssen, Frits M E; Wouters, Emiel F M; Schols, Annemie M W J

    2017-06-01

    It is well established that low muscle mass affects physical performance in chronic obstructive pulmonary disease (COPD). We hypothesize that combined low muscle mass and abdominal obesity may also adversely influence the cardiometabolic risk profile in COPD, even in those with normal weight. The cardiometabolic risk profile and the responsiveness to 4 months high-intensity exercise training was assessed in normal-weight patients with COPD with low muscle mass stratified by abdominal obesity. This is a cross-sectional study including 81 clinically stable patients with COPD (age 62.5 ± 8.2 years; 50.6% males; forced expiratory volume in 1 second 55.1 ± 19.5 percentage predicted) with fat-free mass index risk profile. Triglycerides showed a significant decrease, while the HOMA-IR increased. Abdominal obesity is highly prevalent in normal-weight patients with COPD with low muscle mass who showed an increased cardiometabolic risk compared with patients without abdominal obesity. This cardiometabolic risk profile was not altered after 4 months of exercise training. Copyright © 2017 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.

  10. Contribution of Heritability and Epigenetic Factors to Skeletal Muscle Mass Variation in United Kingdom Twins.

    Science.gov (United States)

    Livshits, Gregory; Gao, Fei; Malkin, Ida; Needhamsen, Maria; Xia, Yudong; Yuan, Wei; Bell, Christopher G; Ward, Kirsten; Liu, Yuan; Wang, Jun; Bell, Jordana T; Spector, Tim D

    2016-06-01

    Skeletal muscle mass (SMM) is one of the major components of human body composition, with deviations from normal values often leading to sarcopenia. Our major aim was to conduct a genome-wide DNA methylation study in an attempt to identify potential genomic regions associated with SMM. This was a mixed cross-sectional and longitudinal study. Community-based study. A total of 1550 middle-aged United Kingdom twins (monozygotic [MZ] and dizygotic [DZ]), 297 of which were repeatedly measured participated in the study. Appendicular lean mass assessed using dual-energy X-ray absorptiometry technology, and methylated DNA immunoprecipitation sequencing DNA methylation profiling genome-wide were obtained from each individual. Heritability estimate of SMM, with simultaneous adjustment for covariates obtained using variance decomposition analysis, was h(2) = 0.809 ± 0.050. After quality control and analysis of longitudinal stability, the DNA methylation data comprised of 723 029 genomic sites, with positive correlations between repeated measurements (Rrepeated = 0.114-0.905). Correlations between MZ and DZ twins were 0.51 and 0.38 at a genome-wide average, respectively, and clearly increased with Rrepeated. Testing for DNA methylation association with SMM in 50 discordant MZ twins revealed 36 081 nominally significant results, of which the top-ranked 134 signals (P 0.40) were subjected to replication in the sample of 1196 individuals. Seven SMM methylation association signals replicated at a false discovery rate less than 0.1, and these were located in or near genes DNAH12, CAND1, CYP4F29P, and ZFP64, which have previously been highlighted in muscle-related studies. Adjusting for age, smoking, and blood cell heterogeneity did not alter significance of these associations. This epigenome-wide study, testing longitudinally stable methylation sites, discovered and replicated a number of associations between DNA methylation at CpG loci and SMM. Four replicated signals were

  11. Nearly collisionless spherical accretion

    International Nuclear Information System (INIS)

    Begelman, M.C.

    1977-01-01

    A fluid-like gas accretes much more efficiently than a collisionless gas. The ability of an accreting gas to behave like a fluid depends on the relationship of the mean free path of a gas particle at r → infinity lambdasub(infinity), to the typical length scales associated with the star-gas system. This relationship is examined in detail. For constant collision cross-section evidence is found for a rapid changeover from collisionless to fluid-like accretion flow when lambdasub(infinity) drops below a certain value, but for hard Coulomb collisions, the transition is more gradual, and is sensitive to the adiabatic index of the gas at r→ infinity. To these results must be added the effects of the substantial cusp of bound particles, which always develops in a system with arbitrarily small but non-zero cross-section. The density run in such a cusp depends on the collision properties of the particles. 'Loss-cone' accretion from the cusp may in some cases exceed the predicted accretion rate. (author)

  12. Electrically Stimulated Antagonist Muscle Contraction Increased Muscle Mass and Bone Mineral Density of One Astronaut - Initial Verification on the International Space Station.

    Science.gov (United States)

    Shiba, Naoto; Matsuse, Hiroo; Takano, Yoshio; Yoshimitsu, Kazuhiro; Omoto, Masayuki; Hashida, Ryuki; Tagawa, Yoshihiko; Inada, Tomohisa; Yamada, Shin; Ohshima, Hiroshi

    2015-01-01

    Musculoskeletal atrophy is one of the major problems of extended periods of exposure to weightlessness such as on the International Space Station (ISS). We developed the Hybrid Training System (HTS) to maintain an astronaut's musculoskeletal system using an electrically stimulated antagonist to resist the volitional contraction of the agonist instead of gravity. The present study assessed the system's orbital operation capability and utility, as well as its preventative effect on an astronaut's musculoskeletal atrophy. HTS was attached to the non-dominant arm of an astronaut staying on the ISS, and his dominant arm without HTS was established as the control (CTR). 10 sets of 10 reciprocal elbow curls were one training session, and 12 total sessions of training (3 times per week for 4 weeks) were performed. Pre and post flight ground based evaluations were performed by Biodex (muscle performance), MRI (muscle volume), and DXA (BMD, lean [muscle] mass, fat mass). Pre and post training inflight evaluations were performed by a hand held dynamometer (muscle force) and a measuring tape (upper arm circumference). The experiment was completed on schedule, and HTS functioned well without problems. Isokinetic elbow extension torque (Nm) changed -19.4% in HTS, and -21.7% in CTR. Isokinetic elbow flexion torque changed -23.7% in HTS, and there was no change in CTR. Total Work (Joule) of elbow extension changed -8.3% in HTS, and +0.3% in CTR. For elbow flexion it changed -23.3% in HTS and -32.6% in CTR. Average Power (Watts) of elbow extension changed +22.1% in HTS and -8.0% in CTR. For elbow flexion it changed -6.5% in HTS and -4.8% in CTR. Triceps muscle volume according to MRI changed +11.7% and that of biceps was +2.1% using HTS, however -0.1% and -0.4% respectively for CTR. BMD changed +4.6% in the HTS arm and -1.2% for CTR. Lean (muscle) mass of the arm changed only +10.6% in HTS. Fat mass changed -12.6% in HTS and -6.4% in CTR. These results showed the orbital operation

  13. Electrically Stimulated Antagonist Muscle Contraction Increased Muscle Mass and Bone Mineral Density of One Astronaut - Initial Verification on the International Space Station.

    Directory of Open Access Journals (Sweden)

    Naoto Shiba

    Full Text Available Musculoskeletal atrophy is one of the major problems of extended periods of exposure to weightlessness such as on the International Space Station (ISS. We developed the Hybrid Training System (HTS to maintain an astronaut's musculoskeletal system using an electrically stimulated antagonist to resist the volitional contraction of the agonist instead of gravity. The present study assessed the system's orbital operation capability and utility, as well as its preventative effect on an astronaut's musculoskeletal atrophy.HTS was attached to the non-dominant arm of an astronaut staying on the ISS, and his dominant arm without HTS was established as the control (CTR. 10 sets of 10 reciprocal elbow curls were one training session, and 12 total sessions of training (3 times per week for 4 weeks were performed. Pre and post flight ground based evaluations were performed by Biodex (muscle performance, MRI (muscle volume, and DXA (BMD, lean [muscle] mass, fat mass. Pre and post training inflight evaluations were performed by a hand held dynamometer (muscle force and a measuring tape (upper arm circumference.The experiment was completed on schedule, and HTS functioned well without problems. Isokinetic elbow extension torque (Nm changed -19.4% in HTS, and -21.7% in CTR. Isokinetic elbow flexion torque changed -23.7% in HTS, and there was no change in CTR. Total Work (Joule of elbow extension changed -8.3% in HTS, and +0.3% in CTR. For elbow flexion it changed -23.3% in HTS and -32.6% in CTR. Average Power (Watts of elbow extension changed +22.1% in HTS and -8.0% in CTR. For elbow flexion it changed -6.5% in HTS and -4.8% in CTR. Triceps muscle volume according to MRI changed +11.7% and that of biceps was +2.1% using HTS, however -0.1% and -0.4% respectively for CTR. BMD changed +4.6% in the HTS arm and -1.2% for CTR. Lean (muscle mass of the arm changed only +10.6% in HTS. Fat mass changed -12.6% in HTS and -6.4% in CTR.These results showed the orbital

  14. Fate of accreting white dwarfs: Type I supernovae vs collapse

    International Nuclear Information System (INIS)

    Nomoto, Ken'ichi.

    1986-01-01

    The final fate of accreting C + O white dwarfs is either thermonuclear explosion or collapse, if the white dwarf mass grows to the Chandrasekhar mass. We discuss how the fate depends on the initial mass, age, composition of the white dwarf and the mass accretion rate. Relatively fast accretion leads to a carbon deflagration at low central density that gives rise to a Type Ia supernova. Slower accretion induces a helium detonation that could be observed as a Type Ib supernova. If the initial mass of the C + O white dwarf is larger than 1.2 Msub solar, a carbon deflagration starts at high central density and induces a collapse of the white dwarf to form a neutron star. We examine the critical condition for which a carbon deflagration leads to collapse, not explosion. For the case of explosion, we discuss to what extent the nucleosynthesis models are consistent with spectra of Type Ia and Ib supernovae. 61 refs., 18 figs

  15. Deficiency of heat shock transcription factor 1 suppresses heat stress-associated increase in slow soleus muscle mass of mice.

    Science.gov (United States)

    Ohno, Y; Egawa, T; Yokoyama, S; Nakai, A; Sugiura, T; Ohira, Y; Yoshioka, T; Goto, K

    2015-12-01

    Effects of heat shock transcription factor 1 (HSF1) deficiency on heat stress-associated increase in slow soleus muscle mass of mice were investigated. Both HSF1-null and wild-type mice were randomly assigned to control and heat-stressed groups. Mice in heat-stressed group were exposed to heat stress (41 °C for 60 min) in an incubator without anaesthesia. Significant increase in wet and dry weights, and protein content of soleus muscle in wild-type mice was observed seven days after the application of the heat stress. However, heat stress had no impact on soleus muscle mass in HSF1-null mice. Neither type of mice exhibited much effect of heat stress on HSF mRNA expression (HSF1, HSF2 and HSF4). On the other hand, heat stress upregulated heat shock proteins (HSPs) at the mRNA (HSP72) and protein (HSP72 and HSP110) levels in wild-type mice, but not in HSF1-null mice. The population of Pax7-positive nuclei relative to total myonuclei of soleus muscle in wild-type mice was significantly increased by heat stress, but not in HSF1-null mice. Furthermore, the absence of HSF1 gene suppressed heat stress-associated phosphorylation of Akt and p70 S6 kinase (p-p70S6K) in soleus muscle. Heat stress-associated increase in skeletal muscle mass may be induced by HSF1 and/or HSF1-mediated stress response that activates muscle satellite cells and Akt/p70S6K signalling pathway. © 2015 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.

  16. Effects of exercise improves muscle strength and fat mass in patients with high fracture risk: A randomized control trial.

    Science.gov (United States)

    Chan, Ding-Cheng; Chang, Chirn-Bin; Han, Der-Sheng; Hong, Cian-Hui; Hwang, Jawl-Shan; Tsai, Keh-Sung; Yang, Rong-Sen

    2017-10-26

    The deterioration of the musculoskeletal system imposes significant impact on physical activity. Exercise is an important strategy which minimizes these changes. It is not clear which type of exercise provides better improvement on low physical performance, low muscle mass and low strength of sarcopenia. We aim to develop an integrated care (IC) model and compare its relative efficacy in limb fat free mass, muscle strength, and physical performance with low extremities exercise (LEE) in community dwelling older adults with high risk of fractures (Fracture Risk Assessment Tool (FRAX ® )) ≧3% for hip fracture, ≧20% for major osteoporotic fracture or 1-min osteoporosis risk test (≧1 point) or fall (≧2 falls in previous year). Patients were assigned randomized to participate in either IC or LEE group (n = 55 each) for 3 months. All participants received education including home-based exercise. The IC group consisted of different modalities of exercise while the LEE group performed machine-based low extremities exercise. Fat free mass, muscle strength, and physical performance were measured at their baseline and 3-months follow-up. Mean age was 73.8 ± 7 years with 69.1% women. Entire cohort demonstrated significant increment in fat free mass, muscle strength (4 indicators) and physical performance (3 indicators). However, between group differences were not significant. With regular supervise exercise; both groups are equally effective in decreasing fat mass and increasing physical performance, muscle mass and strength. However, the IC group required fewer resources and thus more financially feasible in a community setting. Copyright © 2017. Published by Elsevier B.V.

  17. The accretion of migrating giant planets

    Science.gov (United States)

    Dürmann, Christoph; Kley, Wilhelm

    2017-02-01

    Aims: Most studies concerning the growth and evolution of massive planets focus either on their accretion or their migration only. In this work we study both processes concurrently to investigate how they might mutually affect one another. Methods: We modeled a two-dimensional disk with a steady accretion flow onto the central star and embedded a Jupiter mass planet at 5.2 au. The disk is locally isothermal and viscosity is modeled using a constant α. The planet is held on a fixed orbit for a few hundred orbits to allow the disk to adapt and carve a gap. After this period, the planet is released and free to move according to the gravitational interaction with the gas disk. The mass accretion onto the planet is modeled by removing a fraction of gas from the inner Hill sphere, and the removed mass and momentum can be added to the planet. Results: Our results show that a fast migrating planet is able to accrete more gas than a slower migrating planet. Utilizing a tracer fluid we analyzed the origin of the accreted gas originating predominantly from the inner disk for a fast migrating planet. In the case of slower migration, the fraction of gas from the outer disk increases. We also found that even for very high accretion rates, in some cases gas crosses the planetary gap from the inner to the outer disk. Our simulations show that the crossing of gas changes during the migration process as the migration rate slows down. Therefore, classical type II migration where the planet migrates with the viscous drift rate and no gas crosses the gap is no general process but may only occur for special parameters and at a certain time during the orbital evolution of the planet.

  18. SPIN EVOLUTION OF ACCRETING YOUNG STARS. II. EFFECT OF ACCRETION-POWERED STELLAR WINDS

    International Nuclear Information System (INIS)

    Matt, Sean P.; Pinzón, Giovanni; Greene, Thomas P.; Pudritz, Ralph E.

    2012-01-01

    We present a model for the rotational evolution of a young, solar-mass star interacting magnetically with an accretion disk. As in a previous paper (Paper I), the model includes changes in the star's mass and radius as it descends the Hayashi track, a decreasing accretion rate, and a prescription for the angular momentum transfer between the star and disk. Paper I concluded that, for the relatively strong magnetic coupling expected in real systems, additional processes are necessary to explain the existence of slowly rotating pre-main-sequence stars. In the present paper, we extend the stellar spin model to include the effect of a spin-down torque that arises from an accretion-powered stellar wind (APSW). For a range of magnetic field strengths, accretion rates, initial spin rates, and mass outflow rates, the modeled stars exhibit rotation periods within the range of 1-10 days in the age range of 1-3 Myr. This range coincides with the bulk of the observed rotation periods, with the slow rotators corresponding to stars with the lowest accretion rates, strongest magnetic fields, and/or highest stellar wind mass outflow rates. We also make a direct, quantitative comparison between the APSW scenario and the two types of disk-locking models (namely, the X-wind and Ghosh and Lamb type models) and identify some remaining theoretical issues for understanding young star spins.

  19. Gas accretion onto galaxies

    CERN Document Server

    Davé, Romeel

    2017-01-01

    This edited volume presents the current state of gas accretion studies from both observational and theoretical perspectives, and charts our progress towards answering the fundamental yet elusive question of how galaxies get their gas. Understanding how galaxies form and evolve has been a central focus in astronomy for over a century. These studies have accelerated in the new millennium, driven by two key advances: the establishment of a firm concordance cosmological model that provides the backbone on which galaxies form and grow, and the recognition that galaxies grow not in isolation but within a “cosmic ecosystem” that includes the vast reservoir of gas filling intergalactic space. This latter aspect in which galaxies continually exchange matter with the intergalactic medium via inflows and outflows has been dubbed the “baryon cycle”. The topic of this book is directly related to the baryon cycle, in particular its least well constrained aspect, namely gas accretion. Accretion is a rare area of ast...

  20. Relativistic, accreting disks

    International Nuclear Information System (INIS)

    Abramowicz, M.A; Jaroszynski, M.; Sikora, M.

    1978-01-01

    An analytic theory of the hydrodynamical structure of accreting disks (without self-gravitation but with pressure) orbiting around and axially symmetric, stationary, compact body (e.g. black hole) is presented. The inner edge of the marginally stable accreting disk (i.e. disk with constant angular momentum density) has a sharp cusp located on the equatorial plane between rsub(ms) and rsub(mb). The existence of the cusp is also typical for any angular momentum distribution. The physical importance of the cusp follows from the close analogy with the case of a close binary system (L 1 Lagrange point on the Roche lobe). The existence of the cusp is thus a crucial phenomenon in such problems as boundary condition for the viscous stresses, accretion rate etc. (orig.) [de

  1. Relativistic, accreting disks

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, M A; Jaroszynski, M; Sikora, M [Polska Akademia Nauk, Warsaw

    1978-02-01

    An analytic theory of the hydrodynamical structure of accreting disks (without self-gravitation but with pressure) orbiting around an axially symmetric, stationary, compact body (e.g. black hole) is presented. The inner edge of the marginally stable accreting disk (i.e. disk with constant angular momentum density) has a sharp cusp located on the equatorial plane between r/sub ms/ and r/sub mb/. The existence of the cusp is also typical for any angular momentum distribution. The physical importance of the cusp follows from the close analogy with the case of a close binary system (L/sub 1/ Lagrange point on the Roche lobe). The existence of the cusp is thus a crucial phenomenon in such problems as boundary condition for the viscous stresses, accretion rate, etc.

  2. Low vitamin D status is associated with reduced muscle mass and impaired physical performance in frail elderly people

    NARCIS (Netherlands)

    Tieland, C.A.B.; Brouwer, E.M.; Nienaber-Rousseau, C.; Loon, van L.J.C.; Groot, de C.P.G.M.

    2013-01-01

    Background/Objectives: Serum 25-hydroxyvitamin D (25(OH)D) status has been associated with muscle mass, strength and physical performance in healthy elderly people. Yet, in pre-frail and frail elderly people this association has not been studied. The objective of this study was to explore the

  3. The impact of dietary protein or amino acid supplementation on muscle mass and strength in elderly people

    NARCIS (Netherlands)

    Tieland, M.; Franssen, R.; Dullemeijer, C.; Dronkelaar, van C.; Kim, H.K.; Ispoglou, T.; Zhu, K.; Prince, R.L.; Loon, van L.J.C.; Groot, de Lisette C.P.G.M.

    2017-01-01

    Objectives: Increasing protein or amino acid intake has been promoted as a promising strategy to increase muscle mass and strength in elderly people, however, long-term intervention studies show inconsistent findings. Therefore, we aim to determine the impact of protein or amino acid

  4. Low skeletal muscle mass is associated with increased hospital expenditure in patients undergoing cancer surgery of the alimentary tract

    NARCIS (Netherlands)

    J.L.A. van Vugt (Jeroen); S. Büttner (Stefan); S. Levolger (S.); R.R.J. Coebergh van den Braak (Robert); M. Suker (Mustafa); M.P. Gaspersz (Marcia); R.W.F. de Bruin (Ron); C. Verhoef (Kees); Van Eijck, C.H.C. (Casper H. C.); Bossche, N. (Niek); B. Groot Koerkamp (Bas); J.N.M. IJzermans (Jan)

    2017-01-01

    textabstractBackground: Low skeletal muscle mass is associated with poor postoperative outcomes in cancer patients. Furthermore, it is associated with increased healthcare costs in the United States. We investigated its effect on hospital expenditure in a Western-European healthcare system, with

  5. Basic Training of Student’s Outdoor Club Increases Muscle Mass after Five Weeks of Exercise in Males

    Directory of Open Access Journals (Sweden)

    Novie Salsabila

    2015-03-01

    Full Text Available Background: Aerobic and anaerobic exercises, may lead to increase muscle mass. The aim of this study was to determine the change in muscle mass during basic training of students’ outdoor club. Methods: This was an observational analytic study to college students who joined basic training of students’ outdoor club for 19 weeks. Subjects consisted of 17 male and 15 female students, measured five times consecutively by using Body Fat/Hydration monitor scale, with Bioelectrical Impedance Analysis principle. Data collection was performed five times, from February to July 2012 in Bandung. Statistical analysis was processed using Analysis of Variance (ANOVA. Results: The result in males showed the mean 43.35±3.15 on the initial measurement. The muscle mass further increased significantly after five, ten, fifteen, and nineteen weeks of exercise (43.73±3.18 (p0.05; 38.08±1.67 (p>0.05 ; 38.23±1.52 (p>0.05 ; 38.61±1.52 (p<0.05 vs 37.77±2.00 respectively. Conclusion: Basic training of student’s outdoor club increases muscle mass significantly after five weeks of exercise in males, but not in females

  6. Measurement of Muscle Protein Fractional Synthetic Rate by Capillary Gas Chromatography/Combustion Isotope Ratio Mass Spectrometry

    Science.gov (United States)

    Yarasheski, Kevin E.; Smith, Kenneth; Rennie, Michael J.; Bier, Dennis M.

    2014-01-01

    The measurement of skeletal muscle protein fractional synthetic rate using an infusion of (1-13C)leucine and measuring the isotopic abundance of the tracer in skeletal muscle protein by preparative gas chromatography (GC)/ninhydrin isotope ratio mass spectrometry (IRMS) is laborious and subject to errors owing to contamination by 12C. The purpose of this study was to compare muscle (13C)leucine enrichment measured with the conventional preparative GC/ninhydrin IRMS approach to a new, continuous-flow technique using capillary GC/combustion IRMS. Quadriceps muscles were removed from four Sprague–Dawley rats after each was infused at a different rate with (1-13C)leucine for 6–8 h. Muscle leucine enrichment (at.% excess) measured by both methods differed by less than 4%, except at low (13C)leucine enrichments (IRMS was used to assess muscle (13C)leucine enrichment and fractional muscle protein synthesis rate in ten normal young men and women infused with (1,2-13C2)leucine for 12–14 h. This approach reduced the variability of the isotope abundance measure and gave estimates of muscle protein synthesis rate (0.050 ± 0.011% h−1 (mean ± SEM); range = 0.023–0.147% h−1) that agree with published values determined using the standard analytical approach. The measurement of (13C)leucine enrichment from skeletal muscle protein by capillary GC/combustion IRMS provides a simple, acceptable and practical alternative to preparative GC/ninhydrin IRMS. PMID:1420371

  7. Reference Centile Curves for Body Fat Percentage, Fat-free Mass, Muscle Mass and Bone Mass Measured by Bioelectrical Impedance in Asian Indian Children and Adolescents.

    Science.gov (United States)

    Chiplonkar, Shashi; Kajale, Neha; Ekbote, Veena; Mandlik, Rubina; Parthasarathy, Lavanya; Borade, Ashwin; Patel, Pinal; Patel, Prerna; Khadilkar, Vaman; Khadilkar, Anuradha

    2017-12-15

    To create gender-specific percentile curves for percent body fat (%BF) by Bio electrical Impedance Analysis (BIA) for screening adiposity and risk of hypertension in Indian children and generate reference curves for percent fat-free mass (%FFM), muscle mass (%LM) and bone mineral content (BMC) by using bioelectrical impedance. Secondary analysis of data from previous multicenter cross-sectional studies. Private schools from five regions of India. A random sample of 3850 healthy school children (2067 boys) (5-17 yr) from private schools in five major Indian cities. Anthropometry, blood pressure (BP) and body composition were measured by bioelectrical impedance. Reference curves were generated by the LMS method. %BF, %FFM, %LM, BMC and BP. Median %BF increased by 6% from 5 to 13 years of age and declined (around 2%) up to 17 years in boys. In girls, %BF increased by 8% from 5 to 14 years and thereafter declined by 3%. Based upon the risk of hypertension, the new cut-offs of 75th and 85th percentile of %BF were proposed for detecting over fatness and excess fatness in children. Median %FFM was 90% at 5 yrs and decreased till 12 years, and then showed a slight increase to 84% at 17 yrs in boys. In girls, it was 86% at 5 yrs and decreased till 15 yrs, and plateaued at 71.8% at 17 yrs. Reference curves for percent body fat for Indian children would be useful to screen children for health risk in clinical set up.

  8. Pre-main-sequence disk accretion in Z Canis Majoris

    International Nuclear Information System (INIS)

    Hartmann, L.; Kenyon, S.J.; Hewett, R.; Edwards, S.; Strom, K.M.; Strom, S.E.; Stauffer, J.R.

    1989-01-01

    It is suggested that the pre-main-sequence object Z CMa is a luminous accretion disk, similar in many respects to the FU Orionis variables. Z CMa shows the broad, doubled optical absorption lines expected from a rapidly rotating accretion disk. The first overtone CO absorption detected in Z CMa is blue-shifted, suggesting line formation in a disk wind. Accretion at rates about 0.001 solar mass/yr over 100 yr is required to explain the luminosity of Z CMa. The large amount of material accreted (0.1 solar mass/yr) indicates that Z CMa is in a very early stage of stellar evolution, possibly in an initial phase of massive disk accretion. 41 references

  9. Pre-main-sequence disk accretion in Z Canis Majoris

    Science.gov (United States)

    Hartmann, L.; Kenyon, S. J.; Hewett, R.; Edwards, S.; Strom, K. M.; Strom, S. E.; Stauffer, J. R.

    1989-01-01

    It is suggested that the pre-main-sequence object Z CMa is a luminous accretion disk, similar in many respects to the FU Orionis variables. Z CMa shows the broad, doubled optical absorption lines expected from a rapidly rotating accretion disk. The first overtone CO absorption detected in Z CMa is blue-shifted, suggesting line formation in a disk wind. Accretion at rates about 0.001 solar mass/yr over 100 yr is required to explain the luminosity of Z CMa. The large amount of material accreted (0.1 solar mass/yr) indicates that Z CMa is in a very early stage of stellar evolution, possibly in an initial phase of massive disk accretion.

  10. MALDI imaging mass spectrometry: Discrimination of pathophysiological regions in traumatized skeletal muscle by characteristic peptide signatures

    OpenAIRE

    Klein, O.; Strohschein, K.; Nebrich, G.; Oetjen, J.; Trede, D.; Thiele, H.; Alexandrov, T.; Giavalisco, P.; Duda, G.N.; Roth, P. von; Geissler, S.; Klose, J.; Winkler, T.

    2014-01-01

    Due to formation of fibrosis and the loss of contractile muscle tissue, severe muscle injuries often result in insufficient healing marked by a significant reduction of muscle force and motor activity. Our previous studies demonstrated that the local transplantation of mesenchymal stromal cells into an injured skeletal muscle of the rat improves the functional outcome of the healing process. Since, due to the lack of sufficient markers, the accurate discrimination of pathophysiological region...

  11. Changes in lower limb muscle function and muscle mass following exercise-based interventions in patients with chronic obstructive pulmonary disease: A review of the English-language literature.

    Science.gov (United States)

    De Brandt, Jana; Spruit, Martijn A; Hansen, Dominique; Franssen, Frits Me; Derave, Wim; Sillen, Maurice Jh; Burtin, Chris

    2018-05-01

    Chronic obstructive pulmonary disease (COPD) patients often experience lower limb muscle dysfunction and wasting. Exercise-based training has potential to improve muscle function and mass, but literature on this topic is extensive and heterogeneous including numerous interventions and outcome measures. This review uses a detailed systematic approach to investigate the effect of this wide range of exercise-based interventions on muscle function and mass. PUBMED and PEDro databases were searched. In all, 70 studies ( n = 2504 COPD patients) that implemented an exercise-based intervention and reported muscle strength, endurance, or mass in clinically stable COPD patients were critically appraised. Aerobic and/or resistance training, high-intensity interval training, electrical or magnetic muscle stimulation, whole-body vibration, and water-based training were investigated. Muscle strength increased in 78%, muscle endurance in 92%, and muscle mass in 88% of the cases where that specific outcome was measured. Despite large heterogeneity in exercise-based interventions and outcome measures used, most exercise-based trials showed improvements in muscle strength, endurance, and mass in COPD patients. Which intervention(s) is (are) best for which subgroup of patients remains currently unknown. Furthermore, this literature review identifies gaps in the current knowledge and generates recommendations for future research to enhance our knowledge on exercise-based interventions in COPD patients.

  12. RINGED ACCRETION DISKS: INSTABILITIES

    Energy Technology Data Exchange (ETDEWEB)

    Pugliese, D.; Stuchlík, Z., E-mail: d.pugliese.physics@gmail.com, E-mail: zdenek.stuchlik@physics.cz [Institute of Physics and Research Centre of Theoretical Physics and Astrophysics, Faculty of Philosophy and Science, Silesian University in Opava, Bezručovo náměstí 13, CZ-74601 Opava (Czech Republic)

    2016-04-01

    We analyze the possibility that several instability points may be formed, due to the Paczyński mechanism of violation of mechanical equilibrium, in the orbiting matter around a supermassive Kerr black hole. We consider a recently proposed model of a ringed accretion disk, made up by several tori (rings) that can be corotating or counter-rotating relative to the Kerr attractor due to the history of the accretion process. Each torus is governed by the general relativistic hydrodynamic Boyer condition of equilibrium configurations of rotating perfect fluids. We prove that the number of the instability points is generally limited and depends on the dimensionless spin of the rotating attractor.

  13. Muscle strength and regional lean body mass influence on mineral bone health in young male adults.

    Science.gov (United States)

    Guimarães, Bianca Rosa; Pimenta, Luciana Duarte; Massini, Danilo Alexandre; Dos Santos, Daniel; Siqueira, Leandro Oliveira da Cruz; Simionato, Astor Reis; Dos Santos, Luiz Gustavo Almeida; Neiva, Cassiano Merussi; Pessôa Filho, Dalton Muller

    2018-01-01

    The relationship between muscle strength and bone mineral content (BMC) and bone mineral density (BMD) is supposed from the assumption of the mechanical stress influence on bone tissue metabolism. However, the direct relationship is not well established in younger men, since the enhancement of force able to produce effective changes in bone health, still needs to be further studied. This study aimed to analyze the influence of muscle strength on BMC and BMD in undergraduate students. Thirty six men (24.9 ± 8.6 y/o) were evaluated for regional and whole-body composition by dual energy X-ray absorptiometry (DXA). One repetition maximum tests (1RM) were assessed on flat bench-press (BP), lat-pull down (LPD), leg-curl (LC), knee extension (KE), and leg-press 45° (LP45) exercises. Linear regression modelled the relationships of BMD and BMC to the regional body composition and 1RM values. Measurements of dispersion and error (R2adj and standard error of estimate (SEE)) were tested, setting ρ at ≤0.05. The BMD mean value for whole-body was 1.12±0.09 g/cm2 and BMC attained 2477.9 ± 379.2 g. The regional lean mass (LM) in upper-limbs (UL) (= 6.80±1.21 kg) was related to BMC and BMD for UL (R2adj = 0.74, pBMC and BMD for LL (R2adj = 0.68, pBMC (R2adj = 0.47, pBMC (R2adj = 0.36, pBMC and BMD in young men, strengthening the relationship between force and LM, and suggesting both to parametrizes bone mineral health.

  14. Assessment of respiratory muscle strength in children according to the classification of body mass index

    Directory of Open Access Journals (Sweden)

    George Jung da Rosa

    2014-06-01

    Full Text Available OBJECTIVE: To assess and compare the respiratory muscle strength among eutrophic, overweight and obese school children, as well as to identify anthropometric and respiratory variables related to the results.METHODS: Cross-sectional survey with healthy schoolchildren aged 7-9 years old, divided into three groups: Normal weight, Overweight and Obese. The International Study of Asthma and Allergies in Childhood (ISAAC questionnaire was applied. The body mass index (BMI was evaluated, as well as the forced expiratory volume in one second (FEV1 with a portable digital device. The maximal inspiratory and expiratory pressures (MIP and MEP were measured by a digital manometer. Comparisons between the groups were made by Kruskal-Wallis test. Spearman's correlation coefficient was used to analyze the correlations among the variables.RESULTS: MIP of eutrophic school children was higher than MIP found in overweight (p=0.043 and obese (p=0.013 children. MIP was correlated with BMI percentile and weight classification (r=-0.214 and r=-0.256 and MEP was correlated with height (r=0.328. Both pressures showed strong correlation with each other in all analyses (r≥0.773, and less correlation with FEV1 (MIP - r=0.362 and MEP - r=0.494. FEV1 correlated with MEP in all groups (r: 0.429 - 0.569 and with MIP in Obese Group (r=0.565. Age was correlated with FEV1 (r=0.578, MIP (r=0.281 and MEP (r=0.328.CONCLUSIONS: Overweight and obese children showed lower MIP values, compared to eutrophic ones. The findings point to the influence of anthropometric variables on respiratory muscle strength in children.

  15. What's So Special about FGF19-Unique Effects Reported on Skeletal Muscle Mass and Function.

    Science.gov (United States)

    Glass, David J

    2017-08-01

    In a recent study published in Nature Medicine, Benoit et al. (2017) reported unique effects of FGF19 on mouse skeletal muscle: FGF19 induced skeletal muscle hypertrophy and blocked muscle atrophy, acting via FGF receptors and ßKlotho, while a related FGF21 hormone was ineffective. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. Impact of Weight Loss on Physical Function with Changes in Strength, Muscle Mass, and Muscle Fat Infiltration in Overweight to Moderately Obese Older Adults: A Randomized Clinical Trial

    Directory of Open Access Journals (Sweden)

    Adam J. Santanasto

    2011-01-01

    Full Text Available Purpose. Evaluate the effects of weight loss on muscle mass and area, muscle fat infiltration, strength, and their association with physical function. Methods. Thirty-six overweight to moderately obese, sedentary older adults were randomized into either a physical activity plus weight loss (PA+WL or physical activity plus successful aging health education (PA+SA program. Measurements included body composition by dual-energy X-ray absorptiometry, computerized tomography, knee extensor strength, and short physical performance battery (SPPB. Results. At 6 months, PA+WL lost greater thigh fat and muscle area compared to PA+SA. PA+WL lost 12.4% strength; PA+SA lost 1.0%. Muscle fat infiltration decreased significantly in PA+WL and PA+SA. Thigh fat area decreased 6-fold in comparison to lean area in PA+WL. Change in total SPPB score was strongly inversely correlated with change in fat but not with change in lean or strength. Conclusion. Weight loss resulted in additional improvements in function over exercise alone, primarily due to loss of body fat.

  17. Lower Jump Power Rather Than Muscle Mass Itself is Associated with Vertebral Fracture in Community-Dwelling Elderly Korean Women.

    Science.gov (United States)

    Lee, Eun Young; Lee, Su Jin; Kim, Kyoung Min; Seo, Da Hea; Lee, Seung Won; Choi, Han Sol; Kim, Hyeon Chang; Youm, Yoosik; Kim, Chang Oh; Rhee, Yumie

    2017-06-01

    Sarcopenia is considered to be a risk factor for osteoporotic fracture, which is a major health problem in elderly women. In this study, we aimed to investigate the association of sarcopenia, with regard to muscle mass and function, with prevalent vertebral fracture in community-dwelling elderly women. We recruited 1281 women aged 64 to 87 years from the Korean Urban Rural Elderly cohort study. Muscle mass and function were measured using bioimpedance analysis and jumping mechanography. Skeletal muscle index (SMI) and jump power were used as an indicator of muscle mass and function, respectively. Among the participants, we observed 282 (18.9%) vertebral fractures and 564 (44.0%) osteoporosis. Although age, body mass index, and prevalence of osteoporosis increased as both SMI and jump power decreased, prevalence of vertebral fracture increased only when jump power decreased. In univariate analysis, compared with the highest quartile of jump power, the lowest quartile had a significant odds ratio of 2.80 (95% CI 1.79-4.36) for vertebral fracture. This association between jump power and vertebral fracture remained significant, with an odds ratio of 3.04 (95% CI 1.77-5.23), even after adjusting for other risk factors including age, bone mineral density, previous fracture, and cognitive function. In contrast, there was no association between SMI and vertebral fracture. Based on our results, low jump power, but not SMI, is associated with vertebral fracture in community-dwelling elderly Korean women. This finding suggests that jump power may have a more important role than muscle mass itself for osteoporotic fracture.

  18. Thin accretion disk around regular black hole

    Directory of Open Access Journals (Sweden)

    QIU Tianqi

    2014-08-01

    Full Text Available The Penrose′s cosmic censorship conjecture says that naked singularities do not exist in nature.So,it seems reasonable to further conjecture that not even a singularity exists in nature.In this paper,a regular black hole without singularity is studied in detail,especially on its thin accretion disk,energy flux,radiation temperature and accretion efficiency.It is found that the interaction of regular black hole is stronger than that of the Schwarzschild black hole. Furthermore,the thin accretion will be more efficiency to lost energy while the mass of black hole decreased. These particular properties may be used to distinguish between black holes.

  19. WIND-ACCRETION DISKS IN WIDE BINARIES, SECOND-GENERATION PROTOPLANETARY DISKS, AND ACCRETION ONTO WHITE DWARFS

    Energy Technology Data Exchange (ETDEWEB)

    Perets, Hagai B. [Technion-Israel Institute of Technology, Haifa (Israel); Kenyon, Scott J., E-mail: hperets@physics.technion.ac.il [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States)

    2013-02-20

    Mass transfer from an evolved donor star to its binary companion is a standard feature of stellar evolution in binaries. In wide binaries, the companion star captures some of the mass ejected in a wind by the primary star. The captured material forms an accretion disk. Here, we study the evolution of wind-accretion disks, using a numerical approach which allows us to follow the long-term evolution. For a broad range of initial conditions, we derive the radial density and temperature profiles of the disk. In most cases, wind accretion leads to long-lived stable disks over the lifetime of the asymptotic giant branch donor star. The disks have masses of a few times 10{sup -5}-10{sup -3} M {sub Sun }, with surface density and temperature profiles that follow broken power laws. The total mass in the disk scales approximately linearly with the viscosity parameter used. Roughly, 50%-80% of the mass falling into the disk accretes onto the central star; the rest flows out through the outer edge of the disk into the stellar wind of the primary. For systems with large accretion rates, the secondary accretes as much as 0.1 M {sub Sun }. When the secondary is a white dwarf, accretion naturally leads to nova and supernova eruptions. For all types of secondary star, the surface density and temperature profiles of massive disks resemble structures observed in protoplanetary disks, suggesting that coordinated observational programs might improve our understanding of uncertain disk physics.

  20. WIND-ACCRETION DISKS IN WIDE BINARIES, SECOND-GENERATION PROTOPLANETARY DISKS, AND ACCRETION ONTO WHITE DWARFS

    International Nuclear Information System (INIS)

    Perets, Hagai B.; Kenyon, Scott J.

    2013-01-01

    Mass transfer from an evolved donor star to its binary companion is a standard feature of stellar evolution in binaries. In wide binaries, the companion star captures some of the mass ejected in a wind by the primary star. The captured material forms an accretion disk. Here, we study the evolution of wind-accretion disks, using a numerical approach which allows us to follow the long-term evolution. For a broad range of initial conditions, we derive the radial density and temperature profiles of the disk. In most cases, wind accretion leads to long-lived stable disks over the lifetime of the asymptotic giant branch donor star. The disks have masses of a few times 10 –5 -10 –3 M ☉ , with surface density and temperature profiles that follow broken power laws. The total mass in the disk scales approximately linearly with the viscosity parameter used. Roughly, 50%-80% of the mass falling into the disk accretes onto the central star; the rest flows out through the outer edge of the disk into the stellar wind of the primary. For systems with large accretion rates, the secondary accretes as much as 0.1 M ☉ . When the secondary is a white dwarf, accretion naturally leads to nova and supernova eruptions. For all types of secondary star, the surface density and temperature profiles of massive disks resemble structures observed in protoplanetary disks, suggesting that coordinated observational programs might improve our understanding of uncertain disk physics.

  1. Contraction-induced increases in Na+-K+-ATPase mRNA levels in human skeletal muscle are not amplified by activation of additional muscle mass

    DEFF Research Database (Denmark)

    Nordsborg, Nikolai; Thomassen, Martin; Lundby, Carsten

    2005-01-01

    The present study tested the hypothesis that exercise with a large compared with a small active muscle mass results in a higher contraction-induced increase in Na+-K+-ATPase mRNA expression due to greater hormonal responses. Furthermore, the relative abundance of Na+-K+-ATPase subunit a1, a2, a3, a......% of the a2 expression, and no reliable detection of a3 and a4 was possible. In conclusion, activation of additional muscle mass does not result in a higher exercise-induced increase in Na+-K+-ATPase subunit-specific mRNA.......4, ß1, ß2, and ß3 mRNA in human skeletal muscle was investigated. On two occasions, eight subjects performed one-legged knee extension exercise (L) or combined one-legged knee extension and bilateral arm cranking (AL) for 5.00, 4.25, 3.50, 2.75, and 2.00 min separated by 3 min of rest. Leg exercise...

  2. Multiwavelength diagnostics of accretion in an X-ray selected sample of CTTSs

    Science.gov (United States)

    Curran, R. L.; Argiroffi, C.; Sacco, G. G.; Orlando, S.; Peres, G.; Reale, F.; Maggio, A.

    2011-02-01

    Context. High resolution X-ray spectroscopy has revealed soft X-rays from high density plasma in classical T Tauri stars (CTTSs), probably arising from the accretion shock region. However, the mass accretion rates derived from the X-ray observations are consistently lower than those derived from UV/optical/NIR studies. Aims: We aim to test the hypothesis that the high density soft X-ray emission originates from accretion by analysing, in a homogeneous manner, optical accretion indicators for an X-ray selected sample of CTTSs. Methods: We analyse optical spectra of the X-ray selected sample of CTTSs and calculate the accretion rates based on measuring the Hα, Hβ, Hγ, He ii 4686 Å, He i 5016 Å, He i 5876 Å, O i 6300 Å, and He i 6678 Å equivalent widths. In addition, we also calculate the accretion rates based on the full width at 10% maximum of the Hα line. The different optical tracers of accretion are compared and discussed. The derived accretion rates are then compared to the accretion rates derived from the X-ray spectroscopy. Results: We find that, for each CTTS in our sample, the different optical tracers predict mass-accretion rates that agree within the errors, albeit with a spread of ≈ 1 order of magnitude. Typically, mass-accretion rates derived from Hα and He i 5876 Å are larger than those derived from Hβ, Hγ, and O i. In addition, the Hα full width at 10%, whilst a good indicator of accretion, may not accurately measure the mass-accretion rate. When the optical mass-accretion rates are compared to the X-ray derived mass-accretion rates, we find that: a) the latter are always lower (but by varying amounts); b) the latter range within a factor of ≈ 2 around 2 × 10-10 M⊙ yr-1, despite the former spanning a range of ≈ 3 orders of magnitude. We suggest that the systematic underestimate of the X-ray derived mass-accretion rates could depend on the density distribution inside the accretion streams, where the densest part of the stream is

  3. Pulsed Accretion in the T Tauri Binary TWA 3A

    Energy Technology Data Exchange (ETDEWEB)

    Tofflemire, Benjamin M.; Mathieu, Robert D. [Department of Astronomy, University of Wisconsin–Madison, 475 North Charter Street, Madison, WI 53706 (United States); Herczeg, Gregory J. [The Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871 (China); Akeson, Rachel L.; Ciardi, David R. [NASA Exoplanet Science Institute, IPAC/Caltech, Pasadena, CA 91125 (United States)

    2017-06-20

    TWA 3A is the most recent addition to a small group of young binary systems that both actively accrete from a circumbinary disk and have spectroscopic orbital solutions. As such, it provides a unique opportunity to test binary accretion theory in a well-constrained setting. To examine TWA 3A’s time-variable accretion behavior, we have conducted a two-year, optical photometric monitoring campaign, obtaining dense orbital phase coverage (∼20 observations per orbit) for ∼15 orbital periods. From U -band measurements we derive the time-dependent binary mass accretion rate, finding bursts of accretion near each periastron passage. On average, these enhanced accretion events evolve over orbital phases 0.85 to 1.05, reaching their peak at periastron. The specific accretion rate increases above the quiescent value by a factor of ∼4 on average but the peak can be as high as an order of magnitude in a given orbit. The phase dependence and amplitude of TWA 3A accretion is in good agreement with numerical simulations of binary accretion with similar orbital parameters. In these simulations, periastron accretion bursts are fueled by periodic streams of material from the circumbinary disk that are driven by the binary orbit. We find that TWA 3A’s average accretion behavior is remarkably similar to DQ Tau, another T Tauri binary with similar orbital parameters, but with significantly less variability from orbit to orbit. This is only the second clear case of orbital-phase-dependent accretion in a T Tauri binary.

  4. MALDI imaging mass spectrometry: discrimination of pathophysiological regions in traumatized skeletal muscle by characteristic peptide signatures.

    Science.gov (United States)

    Klein, Oliver; Strohschein, Kristin; Nebrich, Grit; Oetjen, Janina; Trede, Dennis; Thiele, Herbert; Alexandrov, Theodore; Giavalisco, Patrick; Duda, Georg N; von Roth, Philipp; Geissler, Sven; Klose, Joachim; Winkler, Tobias

    2014-10-01

    Due to formation of fibrosis and the loss of contractile muscle tissue, severe muscle injuries often result in insufficient healing marked by a significant reduction of muscle force and motor activity. Our previous studies demonstrated that the local transplantation of mesenchymal stromal cells into an injured skeletal muscle of the rat improves the functional outcome of the healing process. Since, due to the lack of sufficient markers, the accurate discrimination of pathophysiological regions in injured skeletal muscle is inadequate, underlying mechanisms of the beneficial effects of mesenchymal stromal cell transplantation on primary trauma and trauma adjacent muscle area remain elusive. For discrimination of these pathophysiological regions, formalin-fixed injured skeletal muscle tissue was analyzed by MALDI imaging MS. By using two computational evaluation strategies, a supervised approach (ClinProTools) and unsupervised segmentation (SCiLS Lab), characteristic m/z species could be assigned to primary trauma and trauma adjacent muscle regions. Using "bottom-up" MS for protein identification and validation of results by immunohistochemistry, we could identify two proteins, skeletal muscle alpha actin and carbonic anhydrase III, which discriminate between the secondary damage on adjacent tissue and the primary traumatized muscle area. Our results underscore the high potential of MALDI imaging MS to describe the spatial characteristics of pathophysiological changes in muscle. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Administration of soluble activin receptor 2B increases bone and muscle mass in a mouse model of osteogenesis imperfecta

    Science.gov (United States)

    DiGirolamo, Douglas J.; Singhal, Vandana; Chang, Xiaoli; Lee, Se-Jin; Germain-Lee, Emily L.

    2015-01-01

    Osteogenesis imperfecta (OI) comprises a group of heritable connective tissue disorders generally defined by recurrent fractures, low bone mass, short stature and skeletal fragility. Beyond the skeletal complications of OI, many patients also report intolerance to physical activity, fatigue and muscle weakness. Indeed, recent studies have demonstrated that skeletal muscle is also negatively affected by OI, both directly and indirectly. Given the well-established interdependence of bone and skeletal muscle in both physiology and pathophysiology and the observations of skeletal muscle pathology in patients with OI, we investigated the therapeutic potential of simultaneous anabolic targeting of both bone and skeletal muscle using a soluble activin receptor 2B (ACVR2B) in a mouse model of type III OI (oim). Treatment of 12-week-old oim mice with ACVR2B for 4 weeks resulted in significant increases in both bone and muscle that were similar to those observed in healthy, wild-type littermates. This proof of concept study provides encouraging evidence for a holistic approach to treating the deleterious consequences of OI in the musculoskeletal system. PMID:26161291

  6. Quantitative analysis of veterinary drugs in bovine muscle and milk by liquid chromatography quadrupole time-of-flight mass spectrometry.

    Science.gov (United States)

    Saito-Shida, Shizuka; Sakai, Takatoshi; Nemoto, Satoru; Akiyama, Hiroshi

    2017-07-01

    A simple and reliable multiresidue method for quantitative determination of veterinary drugs in bovine muscle and milk using liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) was developed. Critical MS parameters such as capillary voltage, cone voltage, collision energy, desolvation gas temperature and extraction mass window were carefully optimised to obtain the best possible sensitivity. Analytical samples were prepared using extraction with acetonitrile and hexane in the presence of anhydrous sodium sulphate and acetic acid, followed by ODS cartridge clean-up. The developed method was validated for 82 veterinary drugs in bovine muscle and milk at spike levels of 0.01 and 0.1 mg kg - 1 . With the exception of cefoperazone and phenoxymethylpenicillin, all these compounds exhibited sufficient signal intensity at 0.01 μg ml -1 (equivalent to 0.01 mg kg - 1 ), indicating the high sensitivity of the developed method. For most targets, the determined accuracies were within 70-120%, with repeatability and reproducibility being below 20% at both levels. Except for sulfathiazole in bovine muscle, no interfering peaks at target compound retention times were detected in the blank extract, indicating that the developed method is highly selective. The absence of sulfathiazole in bovine muscle was confirmed by simultaneous acquisition at low and high collision energies to afford exact masses of molecular adduct and fragment ions. Satisfactory linearity was observed for all compounds, with matrix effects being negligible for most targets in bovine muscle and milk at both spike levels. Overall, the results suggest that the developed LC-QTOF-MS method is suitable for routine regulatory-purpose analysis of veterinary drugs in bovine muscle and milk.

  7. Identification of skeletal muscle mass depletion across age and BMI groups in health and disease--there is need for a unified definition.

    Science.gov (United States)

    Bosy-Westphal, A; Müller, M J

    2015-03-01

    Although reduced skeletal muscle mass is a major predictor of impaired physical function and survival, it remains inconsistently diagnosed to a lack of standardized diagnostic approaches that is reflected by the variable combination of body composition indices and cutoffs. In this review, we summarized basic determinants of a normal lean mass (age, gender, fat mass, body region) and demonstrate limitations of different lean mass parameters as indices for skeletal muscle mass. A unique definition of lean mass depletion should be based on an indirect or direct measure of skeletal muscle mass normalized for height (fat-free mass index (FFMI), appendicular or lumbal skeletal muscle index (SMI)) in combination with fat mass. Age-specific reference values for FFMI or SMI are more advantageous because defining lean mass depletion on the basis of total FFMI or appendicular SMI could be misleading in the case of advanced age due to an increased contribution of connective tissue to lean mass. Mathematical modeling of a normal lean mass based on age, gender, fat mass, ethnicity and height can be used in the absence of risk-defined cutoffs to identify skeletal muscle mass depletion. This definition can be applied to identify different clinical phenotypes like sarcopenia, sarcopenic obesity or cachexia.

  8. A COMMON SOURCE OF ACCRETION DISK TILT

    International Nuclear Information System (INIS)

    Montgomery, M. M.; Martin, E. L.

    2010-01-01

    Many different system types retrogradely precess, and retrograde precession could be from a tidal torque by the secondary on a misaligned accretion disk. However, a source that causes and maintains disk tilt is unknown. In this work, we show that accretion disks can tilt due to a force called lift. Lift results from differing gas stream supersonic speeds over and under an accretion disk. Because lift acts at the disk's center of pressure, a torque is applied around a rotation axis passing through the disk's center of mass. The disk responds to lift by pitching around the disk's line of nodes. If the gas stream flow ebbs, then lift also ebbs and the disk attempts to return to its original orientation. To first approximation, lift does not depend on magnetic fields or radiation sources but does depend on the mass and the surface area of the disk. Also, for disk tilt to be initiated, a minimum mass transfer rate must be exceeded. For example, a 10 -11 M sun disk around a 0.8 M sun compact central object requires a mass transfer rate greater than ∼ 8 x 10 -11 M sun yr -1 , a value well below the known mass transfer rates in cataclysmic variable dwarf novae systems that retrogradely precess and exhibit negative superhumps in their light curves and a value well below mass transfer rates in protostellar-forming systems.

  9. Thin accretion disks in stationary axisymmetric wormhole spacetimes

    International Nuclear Information System (INIS)

    Harko, Tiberiu; Kovacs, Zoltan; Lobo, Francisco S. N.

    2009-01-01

    In this paper, we study the physical properties and the equilibrium thermal radiation emission characteristics of matter forming thin accretion disks in stationary axially symmetric wormhole spacetimes. The thin disk models are constructed by taking different values of the wormhole's angular velocity, and the time averaged energy flux, the disk temperature, and the emission spectra of the accretion disks are obtained. Comparing the mass accretion in a rotating wormhole geometry with the one of a Kerr black hole, we verify that the intensity of the flux emerging from the disk surface is greater for wormholes than for rotating black holes with the same geometrical mass and accretion rate. We also present the conversion efficiency of the accreting mass into radiation, and show that the rotating wormholes provide a much more efficient engine for the transformation of the accreting mass into radiation than the Kerr black holes. Therefore specific signatures appear in the electromagnetic spectrum of thin disks around rotating wormholes, thus leading to the possibility of distinguishing wormhole geometries by using astrophysical observations of the emission spectra from accretion disks.

  10. Effect of Body Mass Index on Postural Balance and Muscle Strength in Children Aged 8-10 years

    Directory of Open Access Journals (Sweden)

    Lucky Prasetiowati

    2017-04-01

    Full Text Available Background:Childhood overweight and obesity, which are considered as global epidemic, can be assessed using Body Mass Index (BMI. BMI difference can lead to anatomic changes due to an increased body load. This increase might also affect motor performance, including changes in postural balance and muscle strength. Aims and Objectives: to explain the influence of BMI on postural balance and lower limb muscle strength and to assess the correlation between those two variables in children aged 8-10 years. Material and methods:The sample consisted of 63 children aged 8-10 years, which were divided in 3 groups: BMI-normal, BMI-overweight, and BMI-obese. The postural balance was assessed using single leg balance test on MatScan and the Center Of Pressure (COP area was recorded. Isometric muscle strength of hip extensor and knee extensor were measured using a hand-held dynamometer. Results: Obese children had significantly largerCOP area than overweight (p = 0.004 and normal weight children (p = 0.000.There were no significant differences in hip extensor muscle strength between obese children with overweight and normal weight children (p=0.527. The absolute knee extensor muscle strength in obese group was significantly higher than the overweight and normal group (p = 0.003. However the relative muscle strength of lower limb for obese children was significantly lower than for normal weight. There was no significant correlation between absolute hip extensor and knee extensor muscles strength with COP area. Conclusion: Obese children have decreased postural balance and increased absolute knee extensormuscle strength significantly when compared to overweight and normal children. There is no significant correlation between postural balance and muscle strength.

  11. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability.

    Science.gov (United States)

    Janssen, Ian; Heymsfield, Steven B; Ross, Robert

    2002-05-01

    To establish the prevalence of sarcopenia in older Americans and to test the hypothesis that sarcopenia is related to functional impairment and physical disability in older persons. Cross-sectional survey. Nationally representative cross-sectional survey using data from the Third National Health and Nutrition Examination Survey (NHANES III). Fourteen thousand eight hundred eighteen adult NHANES III participants aged 18 and older. The presence of sarcopenia and the relationship between sarcopenia and functional impairment and disability were examined in 4,504 adults aged 60 and older. Skeletal muscle mass was estimated from bioimpedance analysis measurements and expressed as skeletal muscle mass index (SMI = skeletal muscle mass/body mass x 100). Subjects were considered to have a normal SMI if their SMI was greater than -one standard deviation above the sex-specific mean for young adults (aged 18-39). Class I sarcopenia was considered present in subjects whose SMI was within -one to -two standard deviations of young adult values, and class II sarcopenia was present in subjects whose SMI was below -two standard deviations of young adult values. The prevalence of class I and class II sarcopenia increased from the third to sixth decades but remained relatively constant thereafter. The prevalence of class I (59% vs 45%) and class II (10% vs 7%) sarcopenia was greater in the older (> or = 60 years) women than in the older men (P normal SMI, respectively. Some of the associations between class II sarcopenia and functional impairment remained significant after adjustment for age, race, body mass index, health behaviors, and comorbidity. Reduced relative skeletal muscle mass in older Americans is a common occurrence that is significantly and independently associated with functional impairment and disability, particularly in older women. These observations provide strong support for the prevailing view that sarcopenia may be an important and potentially reversible cause of

  12. Effect of restriction vegan diet's on muscle mass, oxidative status, and myocytes differentiation: A pilot study.

    Science.gov (United States)

    Vanacore, Daniela; Messina, Giovanni; Lama, Stefania; Bitti, Giuseppe; Ambrosio, Pasqualina; Tenore, Giancarlo; Messina, Antonietta; Monda, Vincenzo; Zappavigna, Silvia; Boccellino, Mariarosaria; Novellino, Ettore; Monda, Marcellino; Stiuso, Paola

    2018-01-10

    This study was conceived to evaluate the effects of three different diets on body composition, metabolic parameters, and serum oxidative status. We enrolled three groups of healthy men (omnivores, vegetarians, and vegans) with similar age, weight and BMI, and we observed a significant decrease in muscle mass index and lean body mass in vegan compared to vegetarian and omnivore groups, and higher serum homocysteine levels in vegetarians and vegans compared to omnivores. We studied whether serum from omnivore, vegetarian, and vegan subjects affected oxidative stress, growth and differentiation of both cardiomyoblast cell line H9c2 and H-H9c2 (H9c2 treated with H 2 O 2 to induce oxidative damage). We demonstrated that vegan sera treatment of both H9c2 and H-H9c2 cells induced an increase of TBARS values and cell death and a decrease of free NO 2- compared to vegetarian and omnivorous sera. Afterwards, we investigated the protective effects of vegan, vegetarian, and omnivore sera on the morphological changes induced by H 2 O 2 in H9c2 cell line. We showed that the omnivorous sera had major antioxidant and differentiation properties compared to vegetarian and vegan sera. Finally, we evaluated the influence of the three different groups of sera on MAPKs pathway and our data suggested that ERK expression increased in H-H9c2 cells treated with vegetarian and vegan sera and could promote cell death. The results obtained in this study demonstrated that restrictive vegan diet could not prevent the onset of metabolic and cardiovascular diseases nor protect by oxidative damage. © 2018 Wiley Periodicals, Inc.

  13. Predicting skeletal muscle mass from dual-energy X-ray absorptiometry in Japanese prepubertal children.

    Science.gov (United States)

    Midorikawa, T; Ohta, M; Hikihara, Y; Torii, S; Sakamoto, S

    2017-10-01

    We aimed to develop regression-based prediction equations for estimating total and regional skeletal muscle mass (SMM) from measurements of lean soft tissue mass (LSTM) using dual-energy X-ray absorptiometry (DXA) and investigate the validity of these equations. In total, 144 healthy Japanese prepubertal children aged 6-12 years were divided into 2 groups: the model development group (62 boys and 38 girls) and the validation group (26 boys and 18 girls). Contiguous MRI images with a 1-cm slice thickness were obtained from the first cervical vertebra to the ankle joints as reference data. The SMM was calculated from the summation of the digitized cross-sectional areas. Total and regional LSTM was measured using DXA. Strong significant correlations were observed between the site-matched SMM (total, arms, trunk and legs) measured by MRI and the LSTM obtained by DXA in the model development group for both boys and girls (R 2 adj =0.86-0.97, Pprediction equations were applied to the validation group, the measured total (boys 9.47±2.21 kg; girls 8.18±2.62 kg) and regional SMM were very similar to the predicted values for both boys (total SMM 9.40±2.39 kg) and girls (total SMM 8.17±2.57 kg). The results of the Bland-Altman analysis for the validation group did not indicate any bias for either boys or girls with the exception of the arm region for the girls. These results suggest that the DXA-derived prediction equations are precise and accurate for the estimation of total and regional SMM in Japanese prepubertal boys and girls.

  14. Age- and gender-dependent values of skeletal muscle mass in healthy children and adolescents.

    Science.gov (United States)

    Webber, Colin E; Barr, Ronald D

    2012-03-01

    Skeletal muscle mass (SMM) can be extracted from whole-body scans obtained by X-ray-based dual-photon absorptiometry (DXA). There is a need to establish expected age-dependent values for children and adolescents. Appendicular lean tissue mass (ALM) was extracted from whole-body DXA scans in 140 healthy children and adolescents (68 females and 72 males). Whole-body SMM was calculated from ALM using equations developed by Kim et al. (Am J Clin Nutr 84:1014-1020, 2006). Age-dependent patterns of increase in SMM were derived by fitting SMM values to equations that consisted of the sum of two logistic expressions, one accounting for SMM changes during growth and the other for SMM changes during puberty. Normal ranges were defined so that 95% of the SMM values were included. The reproducibility of SMM measurements was obtained from whole-body DXA scans repeated on three occasions in each of a separate group of 32 normal children with repositioning between scans. Normal ranges are presented as equations describing the age-dependent pattern of increase in SMM as well as population standard deviations that increased steadily with age. For 15 children below age 10, SMM reproducibility (95% CI) was 149 g (119-199 g) while for 17 children and adolescents over age 10, reproducibility was 170 g (138-223 g). DXA-based measurements of SMM in children and adolescents are reproducible and can be expressed in terms of age-dependent Z scores.

  15. Pre-hospital dietary intake correlates with muscle mass at the time of fracture in older hip fractured patients

    Directory of Open Access Journals (Sweden)

    Riccardo eCalvani

    2014-11-01

    Full Text Available Background. Failure to meet an adequate dietary intake is involved in the pathogenesis of sarcopenia and osteoporosis, which in turn increase the risk for falls and fractures, respectively. Older people with hip fracture are often protein-malnourished at hospitalization. Whether low protein-energy intake is associated with muscle atrophy in hip fractured patients is presently unknown. This information is necessary for the development of novel strategies to manage this especially vulnerable patient population. The aim of this study was therefore to explore the relationship between dietary intake and muscle mass in older hip fractured patients.Methods. Analyses were conducted in hip fractured elderly admitted to an orthopedic and trauma surgery ward (University Hospital. Muscle mass was estimated by bioelectrical impedance analysis within 24 h from admission. Dietary information was collected via 24-h dietary recall and nutrient intakes calculated by a nutrition software.Results. Among 62 hip fractured patients (mean age 84.6±7.6 years, 84% women, the average energy intake was 929.2±170.3 Kcal/day, with higher values reported by men (1.046.8±231.4 Kcal/day relative to women (906.5±148.3 Kcal/day; p=0.01. Absolute and normalized protein intake was 50.0±13.5 g/day and 0.88±0.27 g/kg (body weight/day, respectively, with no gender differences. A positive correlation was determined between total energy intake and muscle mass (r=0.384; p=0.003. Similarly, protein and leucine consumption was positively correlated with muscle mass (r=0.367 and 0.311, respectively; p=0.005 for both.Conclusions. A low intake of calories, protein and leucine is associated with reduced muscle mass in hip fractured elderly. Given the relevance of sarcopenia as a risk factor for adverse outcomes in this patient population, our findings highlight the importance of a comprehensive dietary assessment for the detection of nutritional deficits predisposing to or aggravating

  16. Studies of accreting and non-accreting neutron stars

    International Nuclear Information System (INIS)

    Stollman, G.M.

    1987-01-01

    This thesis is divided into three parts. Part A is devoted to the statistical study of radio pulsars, in which the observations of nearly all known pulsars are used to study their properties such as magnetic field strengths, rotation periods, space velocities as well as their evolution in time. Part B is devoted to the modelling and understanding of quasi-periodic oscillations (QPO) in low-mass X-ray binaries. But, this study is mainly concerned with the accretion process in these sources, and one may hope to learn more about the neutron stars in these systems when the understanding of QPO is improved. In Part C the problem of 'super-Eddington luminosities' in X-ray burst sources is treated. The idea is that a good understanding of the burst process, which takes place directly at the surface of the neutron star, will eventually improve our understanding of the neutron stars themselves. (Auth.)

  17. Skeletal muscle mass and body fat in relation to successful ageing of older adults: The multi-national MEDIS study.

    Science.gov (United States)

    Tyrovolas, Stefanos; Haro, Josep-Maria; Mariolis, Anargiros; Piscopo, Suzanne; Valacchi, Giuseppe; Bountziouka, Vassiliki; Anastasiou, Foteini; Zeimbekis, Akis; Tyrovola, Dimitra; Foscolou, Alexandra; Gotsis, Efthimios; Metallinos, George; Tur, Josep-Antoni; Matalas, Antonia; Lionis, Christos; Polychronopoulos, Evangelos; Panagiotakos, Demosthenes

    2016-01-01

    The determinants that promote successful ageing still remain unknown. The aim of the present work was to evaluate the role of skeletal muscle mass and body fat percentage (BF%), in the level of successful ageing. during 2005-2011, 2663 older (aged 65-100 years) from 21 Mediterranean islands and the rural Mani region (Peloponnesus) of Greece were voluntarily enrolled in the study. Appendicular skeletal muscle mass (ASM), skeletal muscle mass index (SMI) and BF% were calculated using population formulas. Dietary habits, energy intake, expenditure and energy balance were derived throughout standard procedures. A successful ageing index ranging from 0 to 10 was used. The mean ASM mass was 24±6.0kg, the SMI was 0.84±0.21 and the BF% was 44%. Females had lower SMI and higher BF% in comparison with males, respectively [(SMI: 0.66±0.09 vs. 1.03±0.11; BF%: 51% vs. 34%, (pageing, while changes in BF% [b-coefficient (95% CI): -0.04 (-0.05 to -0.03)] were inversely associated with successful ageing. Results from sensitivity analysis showed that the effects of variations on body composition were consistent, less pronounced in the positive energy balance group and more pronounced among the oldest old. Body composition changes seem to be associated with lower quality of life in the older adults, as measured through successful ageing. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  18. High insulin-like growth factor-binding protein-1 (IGFBP-1) is associated with low relative muscle mass in older women

    DEFF Research Database (Denmark)

    Stilling, Frej; Wallenius, Sara; Michaëlsson, Karl

    2017-01-01

    . In the present study we investigate the association between serum IGFBP-1 and muscle mass. Design Cross-sectional analysis of 4908 women, between 55 and 85 years old, participating in the Swedish Mammography Cohort-Clinical. Methods We defined low relative muscle mass (LRMM) as an appendicular lean mass divided...... relative muscle mass. High IGFBP-1 may be a marker of a catabolic state.......Objective Skeletal muscles serve several important roles in maintaining good health. Insulin-like growth factor-1 (IGF-1) is a promoter of protein synthesis in skeletal muscle. Its binding protein, Insulin-like growth factor-binding protein-1 (IGFBP-1) can be one determinant of IGF-1 activity...

  19. Regimes of mini black hole abandoned to accretion

    Science.gov (United States)

    Paik, Biplab

    2018-01-01

    Being inspired by the Eddington’s idea, along with other auxiliary arguments, it is unveiled that there exist regimes of a black hole that would prohibit accretion of ordinary energy. In explicit words, there exists a lower bound to black hole mass below which matter accretion process does not run for black holes. Not merely the baryonic matter, but, in regimes, also the massless photons could get prohibited from rushing into a black hole. However, unlike the baryon accretion abandoned black hole regime, the mass-regime of a black hole prohibiting accretion of radiation could vary along with its ambient temperature. For example, we discuss that earlier to 10‑8 s after the big-bang, as the cosmological temperature of the Universe grew above ˜ 1014 K, the mass range of black hole designating the radiation accretion abandoned regime, had to be in varying state being connected with the instantaneous age of the evolving Universe by an “one half” power law. It happens to be a fact that a black hole holding regimes prohibiting accretion of energy is gigantic by its size in comparison to the Planck length-scale. Hence the emergence of these regimes demands mini black holes for not being viable as profound suckers of energy. Consideration of accretion abandoned regimes could be crucial for constraining or judging the evolution of primordial black holes over the age of the Universe.

  20. Slow movement resistance training using body weight improves muscle mass in the elderly: A randomized controlled trial.

    Science.gov (United States)

    Tsuzuku, S; Kajioka, T; Sakakibara, H; Shimaoka, K

    2018-04-01

    To examine the effect of a 12-week slow movement resistance training using body weight as a load (SRT-BW) on muscle mass, strength, and fat distribution in healthy elderly people. Fifty-three men and 35 women aged 70 years old or older without experience in resistance training participated, and they were randomly assigned to a SRT-BW group or control group. The control group did not receive any intervention, but participants in this group underwent a repeat measurement 12 weeks later. The SRT-BW program consisted of 3 different exercises (squat, tabletop push-up, and sit-up), which were designed to stimulate anterior major muscles. Initially, these exercises were performed by 2 sets of 10 repetitions, and subsequently, the number of repetitions was increased progressively by 2 repetitions every 4 weeks. Participants were instructed to perform each eccentric and concentric phase of movement slowly (spending 4 seconds on each movement), covering the full range of motion. We evaluated muscle mass, strength, and fat distribution at baseline and after 12 weeks of training. Changes over 12 weeks were significantly greater in the SRT-BW group than in the control group, with a decrease in waist circumference, hip circumference, and abdominal preperitoneal and subcutaneous fat thickness, and an increase in thigh muscle thickness, knee extension strength, and hip flexion strength. In conclusion, relatively short-term SRT-BW was effective in improving muscle mass, strength, and fat distribution in healthy elderly people. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  1. The Influence of Body Mass Index, Sex, & Muscle Activation on Pressure Distribution During Lateral Falls on the Hip.

    Science.gov (United States)

    Pretty, Steven P; Martel, Daniel R; Laing, Andrew C

    2017-12-01

    Hip fracture incidence rates are influenced by body mass index (BMI) and sex, likely through mechanistic pathways that influence dynamics of the pelvis-femur system during fall-related impacts. The goal of this study was to extend our understanding of these impact dynamics by investigating the effects of BMI, sex, and local muscle activation on pressure distribution over the hip region during lateral impacts. Twenty participants underwent "pelvis-release experiments" (which simulate a lateral fall onto the hip), including muscle-'relaxed' and 'contracted' trials. Males and low-BMI individuals exhibited 44 and 55% greater peak pressure, as well as 66 and 56% lower peripheral hip force, compared to females and high-BMI individuals, respectively. Local muscle activation increased peak force by 10%, contact area by 17%, and peripheral hip force by 11% compared to relaxed trials. In summary, males and low-BMI individuals exhibited more concentrated loading over the greater trochanter. Muscle activation increased peak force, but this force was distributed over a larger area, preventing increased localized loading over the greater trochanter. These findings suggest potential value in incorporating sex, gender, and muscle activation-specific force distributions as inputs into computational tissue-level models, and have implications for the design of personalized protective devices including wearable hip protectors.

  2. Propeptide-mediated inhibition of myostatin increases muscle mass through inhibiting proteolytic pathways in aged mice.

    Science.gov (United States)

    Collins-Hooper, Henry; Sartori, Roberta; Macharia, Raymond; Visanuvimol, Korntip; Foster, Keith; Matsakas, Antonios; Flasskamp, Hannah; Ray, Steve; Dash, Philip R; Sandri, Marco; Patel, Ketan

    2014-09-01

    Mammalian aging is accompanied by a progressive loss of skeletal muscle, a process called sarcopenia. Myostatin, a secreted member of the transforming growth factor-β family of signaling molecules, has been shown to be a potent inhibitor of muscle growth. Here, we examined whether muscle growth could be promoted in aged animals by antagonizing the activity of myostatin through the neutralizing activity of the myostatin propeptide. We show that a single injection of an AAV8 virus expressing the myostatin propeptide induced an increase in whole body weights and all muscles examined within 7 weeks of treatment. Our cellular studies demonstrate that muscle enlargement was due to selective fiber type hypertrophy, which was accompanied by a shift toward a glycolytic phenotype. Our molecular investigations elucidate the mechanism underpinning muscle hypertrophy by showing a decrease in the expression of key genes that control ubiquitin-mediated protein breakdown. Most importantly, we show that the hypertrophic muscle that develops as a consequence of myostatin propeptide in aged mice has normal contractile properties. We suggest that attenuating myostatin signaling could be a very attractive strategy to halt and possibly reverse age-related muscle loss. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  3. Influence of step-height and body mass on gastrocnemius muscle fascicle behavior during stair ascent.

    NARCIS (Netherlands)

    Spanjaard, M.; Reeves, N.D.; van Dieen, J.H.; Baltzopoulos, V.; Maganaris, C.N.

    2008-01-01

    To better understand the role of the ankle plantar flexor muscles in stair negotiation, we examined the effects of manipulation of kinematic and kinetic constraints on the behavior of the gastrocnemius medialis (GM) muscle during stair ascent. Ten subjects ascended a four-step staircase at four

  4. Hydrodynamic simulations of accretion disks in cataclysmic variables

    International Nuclear Information System (INIS)

    Hirose, Masahito; Osaki, Yoji

    1990-01-01

    The tidal effects of secondary stars on accretion disks in cataclysmic variables are studied by two-dimensional hydrodynamical simulations. The time evolution of an accretion disk under a constant mass supply rate from the secondary is followed until it reaches a quasi-steady state. We have examined various cases of different mass ratios of binary systems. It is found that the accretion disk settles into a steady state of an elongated disk fixed in the rotating frame of the binary in a binary system with comparable masses of component stars. On the other hand, in the case of a low-mass secondary, the accretion disk develops a non-axisymmetric (eccentric) structure and finally settles into a periodically oscillating state in which a non-axisymmetric eccentric disk rotates in the opposite direction to the orbital motion of the binary in the rotating frame of the binary. The period of oscillation is a few percent longer than the orbital period of the binary, and it offers a natural explanation for the ''superhump'' periodicity of SU UMa stars. Our results thus confirm basically those of Whitehurst (1988, AAA 45.064.032) who discovered the tidal instability of an accretion disk in the case of a low-mass secondary. We then discuss the cause of the tidal instability. It is shown that the tidal instability of accretion disks is caused by a parametric resonance between particle orbits and an orbiting secondary star with a 1:3 period ratio. (author)

  5. Genetic variations in the androgen receptor are associated with steroid concentrations and anthropometrics but not with muscle mass in healthy young men.

    Directory of Open Access Journals (Sweden)

    Hélène De Naeyer

    Full Text Available OBJECTIVE: The relationship between serum testosterone (T levels, muscle mass and muscle force in eugonadal men is incompletely understood. As polymorphisms in the androgen receptor (AR gene cause differences in androgen sensitivity, no straightforward correlation can be observed between the interindividual variation in T levels and different phenotypes. Therefore, we aim to investigate the relationship between genetic variations in the AR, circulating androgens and muscle mass and function in young healthy male siblings. DESIGN: 677 men (25-45 years were recruited in a cross-sectional, population-based sibling pair study. METHODS: Relations between genetic variation in the AR gene (CAGn, GGNn, SNPs, sex steroid levels (by LC-MS/MS, body composition (by DXA, muscle cross-sectional area (CSA (by pQCT, muscle force (isokinetic peak torque, grip strength and anthropometrics were studied using linear mixed-effect modelling. RESULTS: Muscle mass and force were highly heritable and related to age, physical activity, body composition and anthropometrics. Total T (TT and free T (FT levels were positively related to muscle CSA, whereas estradiol (E2 and free E2 (FE2 concentrations were negatively associated with muscle force. Subjects with longer CAG repeat length had higher circulating TT, FT, and higher E2 and FE2 concentrations. Weak associations with TT and FT were found for the rs5965433 and rs5919392 SNP in the AR, whereas no association between GGN repeat polymorphism and T concentrations were found. Arm span and 2D:4D finger length ratio were inversely associated, whereas muscle mass and force were not associated with the number of CAG repeats. CONCLUSIONS: Age, physical activity, body composition, sex steroid levels and anthropometrics are determinants of muscle mass and function in young men. Although the number of CAG repeats of the AR are related to sex steroid levels and anthropometrics, we have no evidence that these variations in the AR

  6. Effects of high-intensity exercise and protein supplement on muscle mass in ADL dependent older people with and without malnutrition: a randomized controlled trial.

    Science.gov (United States)

    Carlsson, M; Littbrand, H; Gustafson, Y; Lundin-Olsson, L; Lindelöf, N; Rosendahl, E; Håglin, L

    2011-08-01

    Loss of muscle mass is common among old people living in institutions but trials that evaluate interventions aimed at increasing the muscle mass are lacking. Objective, participants and intervention: This randomized controlled trial was performed to evaluate the effect of a high-intensity functional exercise program and a timed protein-enriched drink on muscle mass in 177 people aged 65 to 99 with severe physical or cognitive impairments, and living in residential care facilities. Three-month high-intensity exercise was compared with a control activity and a protein-enriched drink was compared with a placebo drink. A bioelectrical impedance spectrometer (BIS) was used in the evaluation. The amount of muscle mass and body weight (BW) were followed-up at three and six months and analyzed in a 2 x 2 factorial ANCOVA, using the intention to treat principle, and controlling for baseline values. At 3-month follow-up there were no differences in muscle mass and BW between the exercise and the control group or between the protein and the placebo group. No interaction effects were seen between the exercise and nutritional intervention. Long-term negative effects on muscle mass and BW was seen in the exercise group at the 6-month follow-up. A three month high-intensity functional exercise program did not increase the amount of muscle mass and an intake of a protein-enriched drink immediately after the exercise did not induce any additional effect on muscle mass. There were negative long-term effects on muscle mass and BW, indicating that it is probably necessary to compensate for an increased energy demand when offering a high-intensity exercise program.

  7. Increase in relative skeletal muscle mass over time and its inverse association with metabolic syndrome development: a 7-year retrospective cohort study.

    Science.gov (United States)

    Kim, Gyuri; Lee, Seung-Eun; Jun, Ji Eun; Lee, You-Bin; Ahn, Jiyeon; Bae, Ji Cheol; Jin, Sang-Man; Hur, Kyu Yeon; Jee, Jae Hwan; Lee, Moon-Kyu; Kim, Jae Hyeon

    2018-02-05

    Skeletal muscle mass was negatively associated with metabolic syndrome prevalence in previous cross-sectional studies. The aim of this study was to investigate the impact of baseline skeletal muscle mass and changes in skeletal muscle mass over time on the development of metabolic syndrome in a large population-based 7-year cohort study. A total of 14,830 and 11,639 individuals who underwent health examinations at the Health Promotion Center at Samsung Medical Center, Seoul, Korea were included in the analyses of baseline skeletal muscle mass and those changes from baseline over 1 year, respectively. Skeletal muscle mass was estimated by bioelectrical impedance analysis and was presented as a skeletal muscle mass index (SMI), a body weight-adjusted appendicular skeletal muscle mass value. Using Cox regression models, hazard ratio for developing metabolic syndrome associated with SMI values at baseline or changes of SMI over a year was analyzed. During 7 years of follow-up, 20.1% of subjects developed metabolic syndrome. Compared to the lowest sex-specific SMI tertile at baseline, the highest sex-specific SMI tertile showed a significant inverse association with metabolic syndrome risk (adjusted hazard ratio [AHR] = 0.61, 95% confidence interval [CI] 0.54-0.68). Furthermore, compared with SMI changes metabolic syndrome development were 0.87 (95% CI 0.78-0.97) for 0-1% changes and 0.67 (0.56-0.79) for > 1% changes in SMI over 1 year after additionally adjusting for baseline SMI and glycometabolic parameters. An increase in relative skeletal muscle mass over time has a potential preventive effect on developing metabolic syndrome, independently of baseline skeletal muscle mass and glycometabolic parameters.

  8. Clinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Zhe-rong Xu

    Full Text Available A major reason for the loss of mobility in elderly people is the gradual loss of lean body mass known as sarcopenia. Sarcopenia is associated with a lower quality of life and higher healthcare costs. The benefit of strategies that include nutritional intervention, timing of intervention, and physical exercise to improve muscle loss unclear as finding from studies investigating this issue have been inconsistent. We have performed a systematic review and meta-analysis to assess the ability of protein or amino acid supplementation to augment lean body mass or strength of leg muscles in elderly patients.Nine studies met the inclusion criteria of being a prospective comparative study or randomized controlled trial (RCT that compared the efficacy of an amino acid or protein supplement intervention with that of a placebo in elderly people (≥ 65 years for the improvement of lean body mass (LBM, leg muscle strength or reduction associated with sarcopenia.The overall difference in mean change from baseline to the end of study in LBM between the treatment and placebo groups was 0.34 kg which was not significant (P = 0.386. The overall differences in mean change from baseline in double leg press and leg extension were 2.14 kg (P = 0.748 and 2.28 kg (P = 0.265, respectively, between the treatment group and the placebo group.These results indicate that amino acid/protein supplements did not increase lean body mass gain and muscle strength significantly more than placebo in a diverse elderly population.

  9. Effect of strength training and short-term detraining on muscle mass in women aged over 50 years old

    Directory of Open Access Journals (Sweden)

    Maryam Delshad

    2013-01-01

    Full Text Available Background: The loss of muscle mass is associated with aging. The aim of this study was to determine the effects of resistance training and detraining on muscle mass in elderly women. Methods: Twenty post-menopausal women aged ≥50 years old were enrolled. Matching for age, they were randomly assigned into control and resistance training group (RT. The intervention consisted of three sets of 10 repetitions for 10 movements with Thera-Band tubing (based on 80-100% 10-RM, three times a week, for 12 weeks and thereafter, four weeks detraining. Skinfold thickness was determined by caliper. Percentage of body fat was estimated from skinfold thickness (triceps and subscapular by McArdle method. Fat mass (FM and fat-free mass (FFM were calculated. Range of motion for trunk flexion and extension was determined. Results: During 12 weeks of intervention, significant increases were observed in 1-RM of biceps curl, FFM, trunk flexion and extension and significant decreases during four weeks detraining in RT group. The RT group demonstrated significant decreases during resistance training and increases during detraining in skinfold thickness. FFM, trunk flexion, and extension decreased and skinfold thickness, %FM, and weight of body fat increased in the control group (P < 0.05. Conclusions: Resistance training with Thera-Band enhanced strength and muscle endurance in elderly women and a 4-week detraining period had an adverse effect on muscle power. This suggests that a strength training program is an effective intervention to prevent functional reductions, and can contribute to improve neuromuscular function in older adults.

  10. Muscle mass and physical recovery in ICU: innovations for targeting of nutrition and exercise.

    Science.gov (United States)

    Wischmeyer, Paul E; Puthucheary, Zudin; San Millán, Iñigo; Butz, Daniel; Grocott, Michael P W

    2017-08-01

    We have significantly improved hospital mortality from sepsis and critical illness in last 10 years; however, over this same period we have tripled the number of 'ICU survivors' going to rehabilitation. Furthermore, as up to half the deaths in the first year following ICU admission occur post-ICU discharge, it is unclear how many of these patients ever returned home or a meaningful quality of life. For those who do survive, recent data reveals many 'ICU survivors' will suffer significant functional impairment or post-ICU syndrome (PICS). Thus, new innovative metabolic and exercise interventions to address PICS are urgently needed. These should focus on optimal nutrition and lean body mass (LBM) assessment, targeted nutrition delivery, anabolic/anticatabolic strategies, and utilization of personalized exercise intervention techniques, such as utilized by elite athletes to optimize preparation and recovery from critical care. New data for novel LBM analysis technique such as computerized tomography scan and ultrasound analysis of LBM are available showing objective measures of LBM now becoming more practical for predicting metabolic reserve and effectiveness of nutrition/exercise interventions. 13C-Breath testing is a novel technique under study to predict infection earlier and predict over-feeding and under-feeding to target nutrition delivery. New technologies utilized routinely by athletes such as muscle glycogen ultrasound also show promise. Finally, the role of personalized cardiopulmonary exercise testing to target preoperative exercise optimization and post-ICU recovery are becoming reality. New innovative techniques are demonstrating promise to target recovery from PICS utilizing a combination of objective LBM and metabolic assessment, targeted nutrition interventions, personalized exercise interventions for prehabilitation and post-ICU recovery. These interventions should provide hope that we will soon begin to create more 'survivors' and fewer victim's post

  11. Type VI collagen turnover-related peptides-novel serological biomarkers of muscle mass and anabolic response to loading in young men.

    Science.gov (United States)

    Nedergaard, Anders; Sun, Shu; Karsdal, Morten A; Henriksen, Kim; Kjær, Michael; Lou, Yunyun; He, Yi; Zheng, Qinlong; Suetta, Charlotte

    2013-12-01

    Immobilization-induced loss of muscle mass is a complex phenomenon with several parallels to sarcopenic and cachectic muscle loss. Muscle is a large organ with a protein turnover that is orders of magnitude larger than most other tissues. Thus, we hypothesize that muscle loss and regain is reflected by peptide biomarkers derived from type VI collagen processing released in the circulation. In order to test this hypothesis, we set out to develop an ELISA assay against an type VI collagen N-terminal globular domain epitope (IC6) and measured the levels of IC6 and an MMP-generated degradation fragment of collagen 6, (C6M) in a human immobilization-remobilization study setup with young (n = 11) and old (n = 9) men. They were subjected to 2 weeks of unilateral lower limb immobilization followed by 4 weeks of remobilization including thrice weekly resistance training, using the contralateral leg as internal controls. Subjects were sampled for strength, quadriceps muscle volume and blood at baseline (PRE), post-immobilization (2W), and post-remobilization (4W). Blood were subsequently analyzed for levels of the C6M and IC6 biomarkers. We subsequently tested if there was any correlation between C6M, IC6, or the C6M/IC6 ratio and muscle mass or strength at baseline. We also tested whether there was any relation between these biomarkers and changes in muscle mass or strength with immobilization or remobilization. The model produced significant loss of muscle mass and strength in the immobilized leg. This loss was bigger in young subjects than in elderly, but whereas the young recovered almost fully, the elderly had limited regrowth of muscle. We found a significant correlation between IC6 and muscle mass at baseline in young subjects (R (2) = 0.6563, p = 0.0045), but none in the elderly. We also found a significant correlation between C6M measured at the 4W time point and the change in muscle mass during remobilization, again only manifesting in the young

  12. Lean body mass and muscle function in head and neck cancer patients and healthy individuals - results from the DAHANCA 25 study

    DEFF Research Database (Denmark)

    Lønbro, Simon; Dalgas, Ulrik; Primdahl, Hanne

    2013-01-01

    Abstract Introduction. Loss of lean body mass is common following radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC) and may reduce maximal muscle strength and functional performance. However, the associations between lean body mass, muscle strength and functional...... m max gait speed, 30 s chair rise, 30 s arm curl, stair climb) from HNSCC patients from the DAHANCA 25 trials and data from 24 healthy individuals were included. Results. Lean body mass and maximal muscle strength were significantly associated according to the gender and age-adjusted linear...... regression model (p regression analyses showed that HNSCC patients expressed significant lower levels of the investigated variables after radiotherapy...

  13. Assessment of muscle mass, risk of falls and fear of falling in elderly people with diabetic neuropathy

    Directory of Open Access Journals (Sweden)

    Hudson Azevedo Pinheiro

    Full Text Available Abstract Objective : To assess muscle mass, risk of falls and fear of falling in elderly adults with diabetic neuropathy (DNP. Methods : 50 elderly patients with diabetes mellitus (DM and diabetic neuropathy (NPD participated in this study. Risk of falling was assessed using the Berg Balance Scale (BBS. Fear of falling was assessed by means of the Falls Efficacy Scale-International (FES-I. Muscle mass was assessed by tetrapolar bioimpedance analysis (BIA and Janssen's equation. Subjects were divided into two groups: one with a history of falls in the six months before study enrollment (G1 and the other without history of falls (G2. Results : There were statistically significant differences between G1 and G2 regarding lean body mass (p < 0.05, risk of falls as measured by the BBS (p < 0.01, and fear of falling as measured by the FES-I (p < 0.01. In addition, there was a significant correlation between the BBS and BIA (r = 0.45 and p < 0.01, showing that the greater the lean body mass, the lower the risk of falling. Conclusions : We found an association between lean mass, risk of falls and fear of falling in elderly adults with DNP and a history of falls from own height.

  14. The association of low muscle mass with soluble receptor for advanced glycation end products (sRAGE): The Korean Sarcopenic Obesity Study (KSOS).

    Science.gov (United States)

    Kim, Tae Nyun; Park, Man Sik; Lee, Eun Joo; Chung, Hye Soo; Yoo, Hye Jin; Kang, Hyun Joo; Song, Wook; Baik, Sei Hyun; Choi, Kyung Mook

    2018-03-01

    Advanced glycation end products (AGEs) are accumulated with aging in various tissues of humans. The soluble receptor for AGEs (sRAGE) exerts a protective role against the development of aging-related chronic disorders by neutralizing the action of AGEs. We investigated the implication of sRAGE on low muscle mass in Asian men and women. This cross-sectional study included a 390-participant, nondiabetic subcohort recruited within the framework of the Korean Sarcopenic Obesity Study, an ongoing prospective cohort study. Low muscle mass was defined based on the distribution of appendicular skeletal muscle mass divided by body mass index, as proposed by the Foundation for the National Institutes Sarcopenia Project. Serum sRAGE levels were significantly lower in participants with low muscle mass than in participants without low muscle mass (0.76 [0.60-1.00] ng/mL vs 0.87 [0.67-1.15] ng/mL, P = .005). In age- and sex-adjusted correlation analyses, appendicular skeletal muscle mass divided by body mass index was associated with sRAGE (r = 0.109, P = .037). Furthermore, decreased circulating levels of sRAGE are independently associated with low muscle mass (odds ratio = 0.254, P = .002) after adjusting for confounding factors, including insulin resistance and inflammatory markers. The present study shows that a low circulating level of sRAGE may be an independent risk factor for the presence of low muscle mass. Copyright © 2017 John Wiley & Sons, Ltd.

  15. Feasibility of resistance training in adult McArdle patients: clinical outcomes and muscle strength and mass benefits.

    Science.gov (United States)

    Santalla, Alfredo; Munguía-Izquierdo, Diego; Brea-Alejo, Lidia; Pagola-Aldazábal, Itziar; Díez-Bermejo, Jorge; Fleck, Steven J; Ara, Ignacio; Lucia, Alejandro

    2014-01-01

    We analyzed the effects of a 4-month resistance (weight lifting) training program followed by a 2-month detraining period in 7 adult McArdle patients (5 female) on: muscle mass (assessed by DXA), strength, serum creatine kinase (CK) activity and clinical severity. Adherence to training was ≥84% in all patients and no major contraindication or side effect was noted during the training or strength assessment sessions. The training program had a significant impact on total and lower extremities' lean mass (P training by +855 g (95% confidence interval (CI): 30, 1679) and +547 g (95%CI: 116, 978), respectively, and significantly decreasing with detraining. Body fat showed no significant changes over the study period. Bench press and half-squat performance, expressed as the highest value of average muscle power (W) or force (N) in the concentric-repetition phase of both tests showed a consistent increase over the 4-month training period, and decreased with detraining. Yet muscle strength and power detraining values were significantly higher than pre-training values, indicating that a training effect was still present after detraining. Importantly, all the participants, with no exception, showed a clear gain in muscle strength after the 4-month training period, e.g., bench press: +52 W (95% CI: 13, 91); half-squat: +173 W (95% CI: 96, 251). No significant time effect (P > 0.05) was noted for baseline or post strength assessment values of serum CK activity, which remained essentially within the range reported in our laboratory for McArdle patients. All the patients changed to a lower severity class with training, such that none of them were in the highest disease severity class (3) after the intervention and, as such, they did not have fixed muscle weakness after training. Clinical improvements were retained, in all but one patient, after detraining, such that after detraining all patients were classed as class 1 for disease severity.

  16. Association between muscle mass and adipo-metabolic profile: a cross-sectional study in older subjects

    Directory of Open Access Journals (Sweden)

    Perna S

    2015-02-01

    Full Text Available Simone Perna,1,* Davide Guido,2,* Mario Grassi,2 Mariangela Rondanelli1 1Department of Public Health, Experimental and Forensic Medicine, School of Medicine, Endocrinology and Nutrition Unit, University of Pavia, Azienda di Servizi alla Persona di Pavia, Pavia, Italy; 2Medical and Genomic Statistics Unit, Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy *These authors contributed equally to this work Background: Sarcopenia, the decrease in muscle mass and function, may lead to various negative health outcomes in elderly. The association among sarcopenia with adiposity and metabolic markers has rarely been studied in the elderly population, with controversial results. The aim of this study is to evaluate this relationship in older subjects.Methods: A cross-sectional study was conducted in 290 elderly patients, focusing on the possible association between muscle mass loss, assessed by relative skeletal muscle mass (RSMM, and an adipo-metabolic profile (AMP defined by adiposity and metabolic biochemical markers. Measurements of body composition were assessed by dual energy X-ray absorptiometry. Biochemical parameters, such as albumin, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, total cholesterol, triglycerides, C-reactive protein, and homocysteine and its related markers (folate and vitamin B12 were measured. Using canonical correlation analysis and structural equation modeling, an individual score of AMP was created and correlated with RSMM.Results: The AMP–RSMM correlation was equal to +0.642 (95% confidence interval, +0.512 to +0.773; P<0.001. Hence, a negative association between sarcopenia severity and adiposity/metabolic biochemical markers was highlighted.Conclusion: This study contained a novel way to examine the relationship between the variables of interest based on a composite index of adiposity and metabolic conditions. Results shed light on the orientation and magnitude of

  17. Ratio of Dietary n-6/n-3 Polyunsaturated Fatty Acids Independently Related to Muscle Mass Decline in Hemodialysis Patients.

    Directory of Open Access Journals (Sweden)

    Te-Chih Wong

    Full Text Available n-3 polyunsaturated fatty acids (PUFAs might be useful nutritional strategy for treating patients with sarcopenia. We evaluated the effect of the intake of dietary n-3 PUFAs on the skeletal muscle mass (SMM, appendicular skeletal muscle mass (ASM, and its determinants in patients receiving standard hemodialysis (HD treatment for the management of end stage renal disease.In this cross-sectional study, data of 111 HD patients were analyzed. Anthropometric and bioelectrical impedance measurements used to estimate the muscle mass were performed the day of dialysis immediately after the dialysis session. Routine laboratory and 3-day dietary data were also collected. The cutoff value of adequate intake (AI for both n-3 PUFAs and alpha-linolenic acid (ALA was 1.6 g/day and 1.1 g/day for men and women, respectively.The mean age, mean dietary n-3 PUFAs intake, ALA intake, ratio of n-6/n-3 PUFAs intake, SMM, and ASM of patients were 61.4 ± 10.4 years, 2.0 ± 1.3 g/day, 1.5 ± 1.0 g/day, 9.5 ± 6.7 g/day, 23.9 ± 5.5 kg, and 17.5 ± 4.5 kg, respectively. A higher SMM and ASM significantly observed in patients who achieved an AI of n-3 PUFAs. Similar trends appeared to be observed among those patients who achieved the AI of ALA, but the difference was not significantly, except for ASM (P = 0.047. No relevant differences in demographics, laboratory and nutritional parameters were observed, regardless of whether the patients achieved an AI of n-3 PUFAs. Multivariate analysis showed that the BMI and equilibrated Kt/V were independent determinants of the muscle mass. Moreover, the ratio of n-6/n-3 PUFAs was an independent risk determinant of reduced ASM in HD patients.Patients with an AI of n-3 PUFAs had better total-body SMM and ASM. A higher dietary ratio of n-6/n-3 PUFAs seemed to be associated with a reduced muscle mass in HD patients.

  18. Ratio of Dietary n-6/n-3 Polyunsaturated Fatty Acids Independently Related to Muscle Mass Decline in Hemodialysis Patients.

    Science.gov (United States)

    Wong, Te-Chih; Chen, Yu-Tong; Wu, Pei-Yu; Chen, Tzen-Wen; Chen, Hsi-Hsien; Chen, Tso-Hsiao; Yang, Shwu-Huey

    2015-01-01

    n-3 polyunsaturated fatty acids (PUFAs) might be useful nutritional strategy for treating patients with sarcopenia. We evaluated the effect of the intake of dietary n-3 PUFAs on the skeletal muscle mass (SMM), appendicular skeletal muscle mass (ASM), and its determinants in patients receiving standard hemodialysis (HD) treatment for the management of end stage renal disease. In this cross-sectional study, data of 111 HD patients were analyzed. Anthropometric and bioelectrical impedance measurements used to estimate the muscle mass were performed the day of dialysis immediately after the dialysis session. Routine laboratory and 3-day dietary data were also collected. The cutoff value of adequate intake (AI) for both n-3 PUFAs and alpha-linolenic acid (ALA) was 1.6 g/day and 1.1 g/day for men and women, respectively. The mean age, mean dietary n-3 PUFAs intake, ALA intake, ratio of n-6/n-3 PUFAs intake, SMM, and ASM of patients were 61.4 ± 10.4 years, 2.0 ± 1.3 g/day, 1.5 ± 1.0 g/day, 9.5 ± 6.7 g/day, 23.9 ± 5.5 kg, and 17.5 ± 4.5 kg, respectively. A higher SMM and ASM significantly observed in patients who achieved an AI of n-3 PUFAs. Similar trends appeared to be observed among those patients who achieved the AI of ALA, but the difference was not significantly, except for ASM (P = 0.047). No relevant differences in demographics, laboratory and nutritional parameters were observed, regardless of whether the patients achieved an AI of n-3 PUFAs. Multivariate analysis showed that the BMI and equilibrated Kt/V were independent determinants of the muscle mass. Moreover, the ratio of n-6/n-3 PUFAs was an independent risk determinant of reduced ASM in HD patients. Patients with an AI of n-3 PUFAs had better total-body SMM and ASM. A higher dietary ratio of n-6/n-3 PUFAs seemed to be associated with a reduced muscle mass in HD patients.

  19. Low vitamin D status is associated with reduced muscle mass and impaired physical performance in frail elderly people.

    Science.gov (United States)

    Tieland, M; Brouwer-Brolsma, E M; Nienaber-Rousseau, C; van Loon, L J C; De Groot, L C P G M

    2013-10-01

    Serum 25-hydroxyvitamin D (25(OH)D) status has been associated with muscle mass, strength and physical performance in healthy elderly people. Yet, in pre-frail and frail elderly people this association has not been studied. The objective of this study was to explore the association between vitamin D intake and serum 25(OH)D status with muscle mass, strength and physical performance in a pre-frail and frail elderly population. This cross-sectional study included 127 pre-frail and frail elderly people in The Netherlands. Whole body and appendicular lean mass (ALM) (dual energy X-ray absorptiometry), leg strength (one repetition maximum), handgrip strength and physical performance (short physical performance battery) were measured, and blood samples were collected for the assessment of serum 25(OH)D status (liquid chromatography-tandem mass spectrometry). In addition, habitual dietary intake (3-day food records) and physical activity data (accelerometers) were collected. In total, 53% of the participants had a serum 25(OH)D level below 50  nmol/l. After adjustment for confounding factors, 25(OH)D status was associated with ALM (β=0.012, P=0.05) and with physical performance (β=0.020, PVitamin D intake was associated with physical performance (β=0.18, P0.05). In this frail elderly population, 25(OH)D status is low and suggests a modest association with reduced ALM and impaired physical performance. In addition, vitamin D intake tended to be associated with impaired physical performance. Our findings highlight the need for well-designed intervention trials to assess the impact of vitamin D supplementation on 25(OH)D status, muscle mass and physical performance in pre-frail and frail elderly people.

  20. Stability of black hole accretion disks

    Directory of Open Access Journals (Sweden)

    Czerny B.

    2012-12-01

    Full Text Available We discuss the issues of stability of accretion disks that may undergo the limit-cycle oscillations due to the two main types of thermal-viscous instabilities. These are induced either by the domination of radiation pressure in the innermost regions close to the central black hole, or by the partial ionization of hydrogen in the zone of appropriate temperatures. These physical processes may lead to the intermittent activity in AGN on timescales between hundreds and millions of years. We list a number of observational facts that support the idea of the cyclic activity in high accretion rate sources. We conclude however that the observed features of quasars may provide only indirect signatures of the underlying instabilities. Also, the support from the sources with stellar mass black holes, whose variability timescales are observationally feasible, is limited to a few cases of the microquasars. Therefore we consider a number of plausible mechanisms of stabilization of the limit cycle oscillations in high accretion rate accretion disks. The newly found is the stabilizing effect of the stochastic viscosity fluctuations.

  1. Physical activity as intervention for age-related loss of muscle mass and function

    DEFF Research Database (Denmark)

    Eriksen, Christian Skou; Garde, Ellen; Reislev, Nina Linde

    2016-01-01

    insights into training-induced promotion of functional ability and independency after retirement and will help to formulate national recommendations regarding physical activity schemes for the growing population of older individuals in western societies. Results will be published in scientific peer......INTRODUCTION: Physical and cognitive function decline with age, accelerating during the 6th decade. Loss of muscle power (force×velocity product) is a dominant physical determinant for loss of functional ability, especially if the lower extremities are affected. Muscle strength training is known...... to maintain or even improve muscle power as well as physical function in older adults, but the optimal type of training for beneficial long-term training effects over several years is unknown. Moreover, the impact of muscle strength training on cognitive function and brain structure remains speculative...

  2. Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: a randomized double-blind, placebo-controlled trial

    NARCIS (Netherlands)

    Tieland, C.A.B.; Dirks, M.L.; Zwaluw, van der N.L.; Verdijk, L.; Rest, van de O.; Groot, de C.P.G.M.; Loon, van L.C.

    2012-01-01

    Objectives Protein supplementation has been proposed as an effective dietary strategy to augment the skeletal muscle adaptive response to prolonged resistance-type exercise training in elderly people. Our objective was to assess the impact of protein supplementation on muscle mass, strength, and

  3. Low muscle mass is associated with metabolic syndrome only in nonobese young adults: the Korea National Health and Nutrition Examination Survey 2008-2010.

    Science.gov (United States)

    Kim, Byung Chul; Kim, Mee Kyoung; Han, Kyungdo; Lee, Sae-Young; Lee, Seung-Hwan; Ko, Seung-Hyun; Kwon, Hyuk-Sang; Merchant, Anwar T; Yim, Hyeon Woo; Lee, Won-Chul; Park, Yong Gyu; Park, Yong-Moon

    2015-12-01

    Little is known about the relationship between body composition and metabolic risk factors in young adults. We hypothesized that low muscle mass (LMM) is associated with metabolic syndrome (MetS) and its components in young adults and that the associations vary by obesity. A cross-sectional analysis was conducted using the Korea National Health and Nutrition Examination Survey data. In total, 5300 young adults aged 19 to 39 years were evaluated. Low muscle mass was defined as an appendicular skeletal muscle mass/weight less than 1 SD below the mean for each participant's corresponding sex and age group. Obesity was defined as a body mass index greater than or equal to 25 kg/m2. The prevalence of LMM was higher in obese than nonobese participants (37.6% vs. 9.6%). In the nonobese participants, the prevalence of MetS, high waist circumference, high triglycerides, and high blood pressure was significantly greater in the LMM group than in the high muscle mass group. In the nonobese group, compared with high muscle mass participants, those with LMM had odds ratios for MetS of 3.6 (95% confidence interval, 1.48-8.76; P young adults with LMM may have a high risk of MetS, especially when they are nonobese. Interventions aimed at increasing muscle mass at younger ages may have the potential to reduce MetS. Published by Elsevier Inc.

  4. Accretion onto a moving Reissner-Nordström black hole

    Energy Technology Data Exchange (ETDEWEB)

    Jiao, Lei; Yang, Rongjia, E-mail: jiaoleizhijia@163.com, E-mail: yangrongjia@tsinghua.org.cn [College of Physical Science and Technology, Hebei University, No. 180, Wusi east road, Baoding 071002 (China)

    2017-09-01

    We obtain an analytic solution for accretion of a gaseous medium with a adiabatic equation of state ( P =ρ) onto a Reissner-Nordström black hole which moves at a constant velocity through the medium. We obtain the specific expression for each component of the velocity and present the mass accretion rate which depends on the mass and the electric charge. The result we obtained may be helpful to understand the physical mechanism of accretion onto a moving black hole.

  5. Super-Eddington Accretion in Tidal Disruption Events: the Impact of Realistic Fallback Rates on Accretion Rates

    Science.gov (United States)

    Wu, Samantha; Coughlin, Eric R.; Nixon, Chris

    2018-04-01

    After the tidal disruption of a star by a massive black hole, disrupted stellar debris can fall back to the hole at a rate significantly exceeding its Eddington limit. To understand how black hole mass affects the duration of super-Eddington accretion in tidal disruption events, we first run a suite of simulations of the disruption of a Solar-like star by a supermassive black hole of varying mass to directly measure the fallback rate onto the hole, and we compare these fallback rates to the analytic predictions of the "frozen-in" model. Then, adopting a Zero-Bernoulli Accretion flow as an analytic prescription for the accretion flow around the hole, we investigate how the accretion rate onto the black hole evolves with the more accurate fallback rates calculated from the simulations. We find that numerically-simulated fallback rates yield accretion rates onto the hole that can, depending on the black hole mass, be nearly an order of magnitude larger than those predicted by the frozen-in approximation. Our results place new limits on the maximum black hole mass for which super-Eddington accretion occurs in tidal disruption events.

  6. COMPETITIVE ACCRETION IN A SHEET GEOMETRY AND THE STELLAR IMF

    International Nuclear Information System (INIS)

    Hsu, Wen-Hsin; Hartmann, Lee; Heitsch, Fabian; Gomez, Gilberto C.

    2010-01-01

    We report a set of numerical experiments aimed at addressing the applicability of competitive accretion to explain the high-mass end of the stellar initial mass function in a sheet geometry with shallow gravitational potential, in contrast to most previous simulations which have assumed formation in a cluster gravitational potential. Our flat cloud geometry is motivated by models of molecular cloud formation due to large-scale flows in the interstellar medium. The experiments consisted of smoothed particle hydrodynamics simulations of gas accretion onto sink particles formed rapidly from Jeans-unstable dense clumps placed randomly in the finite sheet. These simplifications allow us to study accretion with a minimum of free parameters and to develop better statistics on the resulting mass spectra. We considered both clumps of equal mass and Gaussian distributions of masses and either uniform or spatially varying gas densities. In all cases, the sink mass function develops a power-law tail at high masses, with dN/dlog M ∝ M -Γ . The accretion rates of individual sinks follow M-dot ∝M 2 at high masses; this results in a continual flattening of the slope of the mass function toward an asymptotic form Γ ∼ 1 (where the Salpeter slope is Γ = 1.35). The asymptotic limit is most rapidly reached when starting from a relatively broad distribution of initial sink masses. In general, the resulting upper mass slope is correlated with the maximum sink mass; higher sink masses are found in simulations with flatter upper mass slopes. Although these simulations are of a highly idealized situation, the results suggest that competitive accretion may be relevant in a wider variety of environments than previously considered, and in particular that the upper mass distribution may generally evolve toward a limiting value of Γ ∼ 1.

  7. Visceral obesity, fat mass/muscle mass ratio and atherogenic dyslipidemia: cross-sectional study. Riobamba, Ecuador

    Directory of Open Access Journals (Sweden)

    Tomas Marcelo Nicolalde Cifuentes

    2015-10-01

    Full Text Available Introduction: The distribution and composition of fat mass is associated with different metabolic risks. The predominance of brown visceral fat is associated with risk factors for cardiovascular disease (CVD, such as: high triglycerides and apolipoprotein B, increased LDL cholesterol, ratio triglycerides/low HDL cholesterol elevated (atherogenic dyslipidemia indicator, insulin resistance, hyperinsulinemia and cardiovascular risk (CVR. Sarcopenia and obesity may act synergistically in functional and metabolic disorders. The aim of this study was to determine the relationship between visceral obesity, fat mass/muscular mass ratio and atherogenic dyslipidemia in adult individuals in order to determine the association pattern between these variables and set strategies for focused attention.Material and Methods: In a sample of 307 subjects of both sexes (21-71 years there was measured atherogenic dyslipidemia as the ratio of triglyceride/HDL cholesterol, visceral obesity measured by bio impedance as the relative score of visceral fat, and the ratio fat mass/lean mass.Results: A cluster analysis was performed to establish the structure of association between these variables with different risk groups. Three groups were identified: the first had visceral obesity with an average relative level of visceral fat of 13.6, the second group with an average of 8.9 and in the third group were placed individuals with the lowest visceral obesity score averaging 6.5. As for the fat mass/lean mas ratio the first two groups had a similar average of this index with a value of 1.56 and 1.69 respectively and the third group with the lowest average value of 1.3. Group 1 presented visceral obesity and impaired fat mass/lean mass ratio and had a high value of triglyceride/HDL ratio 4.1. Group 2 without visceral obesity and a deterioration in the relative fat mass/lean mass ratio had a triglyceride/HDL cholesterol of 3.6 and Group 3; not recorded visceral obesity or

  8. Superluminous accretion discs

    Energy Technology Data Exchange (ETDEWEB)

    Sikora, M [Cambridge Univ. (UK). Inst. of Astronomy; Polska Akademia Nauk, Warsaw. Centrum Astronomiczne)

    1981-07-01

    Upper limits are computed for the total luminosities and collimation of radiation from thick, radiation supported accretion discs around black holes. Numerical results are obtained for the 'extreme' discs with rsub(out) = 10/sup 3/ GMsub(BH)/c/sup 2/, the angular momentum of the black hole being Jsub(BH) = 0.998 GMsub(BH)/c. The high luminosity (L approximately 8.5 Lsub(Edd)) and substantial collimation of radiation found for these discs indicate that such discs can explain both the high luminosities of quasars and similar objects and may produce some of the observed beams and jets.

  9. Source to Accretion Disk Tilt

    OpenAIRE

    Montgomery, M. M.; Martin, E. L.

    2010-01-01

    Many different system types retrogradely precess, and retrograde precession could be from a tidal torque by the secondary on a misaligned accretion disk. However, a source to cause and maintain disk tilt is unknown. In this work, we show that accretion disks can tilt due to a force called lift. Lift results from differing gas stream supersonic speeds over and under an accretion disk. Because lift acts at the disk's center of pressure, a torque is applied around a rotation axis passing through...

  10. Effect of modified fasting therapy on body weight, fat and muscle mass, and blood chemistry in patients with obesity.

    Science.gov (United States)

    Kim, Koh-Woon; Song, Mi-Yeon; Chung, Seok-Hee; Chung, Won-Seok

    2016-02-01

    The aim of this study was to investigate the effects and safety of modified fasting therapy using fermented medicinal herbs and exercise on body weight, fat and muscle mass, and blood chemistry in obese subjects. Twenty-six patients participated in a 14-day fast, during which they ingested a supplement made from fermented medicinal herbs and carbohydrates (intake: 400-600 kcal/d). The schedule included 7 prefasting relief days and 14 days of stepwise reintroduction of food. The patients also took part in an exercise program that incorporated Qigong, weight training, and walking exercises. The efficacy of treatments was observed by assessing body fat mass and muscle mass, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), cholesterol, and triglycerides in each study period. Specific symptoms or side effects were reported. Body weight and body fat mass both decreased significantly by (5.16 ± 0.95) and (3.89 ± 0.79) kg (both P fasting therapy using fermented medicinal herbs and exercise could be effective and safe on obese patients.

  11. Lack of independent effect of type 2 diabetes beyond characteristic comorbidities and medications on small muscle mass exercising muscle blood flow and exercise tolerance.

    Science.gov (United States)

    Poitras, Veronica J; Bentley, Robert F; Hopkins-Rosseel, Diana H; LaHaye, Stephen A; Tschakovsky, Michael E

    2015-08-01

    Persons with type 2 diabetes (T2D) are believed to have reduced exercise tolerance; this may be partly due to impaired exercising muscle blood flow (MBF). Whether there is an impact of T2D on exercising MBF within the typical constellation of comorbidities (hypertension, dyslipidemia, obesity) and their associated medications has not been investigated. We tested the hypothesis that small muscle mass exercise tolerance is reduced in persons with T2D versus Controls (matched for age, body mass index, fitness, comorbidities, non-T2D medications) and that this is related to blunted MBF. Eight persons with T2D and eight controls completed a forearm critical force (fCFimpulse) test as a measure of exercise tolerance (10-min intermittent maximal effort forearm contractions; the average contraction impulse in the last 30 sec quantified fCFimpulse). Forearm blood flow (FBF; ultrasound) and mean arterial pressure (MAP; finger photoplethysmography) were measured; forearm vascular conductance (FVK) was calculated. Data are means ± SD, T2D versus Control. fCFimpulse was not different between groups (136.9 ± 47.3  N·sec vs. 163.1 ± 49.7 N·sec, P = 0.371) nor was the ∆FBF from rest to during exercise at fCFimpulse (502.9 ± 144.6 vs. 709.1 ± 289.2 mL/min, P = 0.092), or its determinants ∆FVK and ∆MAP (both P > 0.05), although there was considerable interindividual variability. ∆FBF was strongly related to fCFimpulse (r = 0.727, P = 0.002), providing support for the relationship between oxygen delivery and exercise tolerance. We conclude that small muscle mass exercising MBF and exercise tolerance are not impaired in representative persons with T2D versus appropriately matched controls. This suggests that peripheral vascular control impairment does not contribute to reduced exercise tolerance in this population. © 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and

  12. Magnetic fields and accretion discs around static black holes

    International Nuclear Information System (INIS)

    Dadhich, N.

    1982-01-01

    Some aspects of accretion onto static black holes immersed in a uniform magnetic field are investigated. The Ernst metric is employed to find the 'Keplerian' angular momentum distribution and the efficiency of mass-to-energy conversion for a plasma and for test particles. Under almost all physically reasonable conditions for hydrodynamic accretion the effect of the magnetic field is small. However, for test particles the effect can be very important and the efficiency can approach unity. (author)

  13. Comparison between clinical significance of height-adjusted and weight-adjusted appendicular skeletal muscle mass.

    Science.gov (United States)

    Furushima, Taishi; Miyachi, Motohiko; Iemitsu, Motoyuki; Murakami, Haruka; Kawano, Hiroshi; Gando, Yuko; Kawakami, Ryoko; Sanada, Kiyoshi

    2017-02-13

    This study aimed to compare relationships between height- or weight-adjusted appendicular skeletal muscle mass (ASM/Ht 2 or ASM/Wt) and risk factors for cardiometabolic diseases or osteoporosis in Japanese men and women. Subjects were healthy Japanese men (n = 583) and women (n = 1218). The study population included a young group (310 men and 357 women; age, 18-40 years) and a middle-aged and elderly group (273 men and 861 women; age, ≥41 years). ASM was measured by dual-energy X-ray absorptiometry. The reference values for class 1 and 2 sarcopenia in each sex were defined as values one and two standard deviations below the sex-specific means of the young group, respectively. The reference values for class 1 and 2 sarcopenia defined by ASM/Ht 2 were 7.77 and 6.89 kg/m 2 in men and 6.06 and 5.31 kg/m 2 in women, respectively. The reference values for ASM/Wt were 35.0 and 32.0% in men and 29.6 and 26.4% in women, respectively. In both men and women, ASM/Wt was negatively correlated with higher triglycerides (TG) and positively correlated with serum high-density lipoprotein cholesterol (HDL-C), but these associations were not found in height-adjusted ASM. In women, TG, systolic blood pressure, and diastolic blood pressure in sarcopenia defined by ASM/Wt were significantly higher than those in normal subjects, but these associations were not found in sarcopenia defined by ASM/Ht 2 . Whole-body and regional bone mineral density in sarcopenia defined by ASM/Ht 2 were significantly lower than those in normal subjects, but these associations were not found in sarcopenia defined by ASM/Wt. Weight-adjusted definition was able to identify cardiometabolic risk factors such as TG and HDL-C while height-adjusted definition could identify factors for osteoporosis.

  14. Mechanical muscle function and lean body mass during supervised strength training and testosterone therapy in aging men with low-normal testosterone levels

    DEFF Research Database (Denmark)

    Kvorning, Thue; Christensen, Louise L; Madsen, Klavs

    2013-01-01

    To examine the effect of strength training and testosterone therapy on mechanical muscle function and lean body mass (LBM) in aging men with low-normal testosterone levels in a randomized, double-blind, placebo-controlled 24-week study.......To examine the effect of strength training and testosterone therapy on mechanical muscle function and lean body mass (LBM) in aging men with low-normal testosterone levels in a randomized, double-blind, placebo-controlled 24-week study....

  15. Sports Mass Age Therapy on the Reduction of Delayed Onset Muscle Soreness of the Quadriceps Femoris

    Directory of Open Access Journals (Sweden)

    Boguszewski Dariusz

    2014-12-01

    Full Text Available Purpose. Massage therapy is one of most commonly applied treatments during athletic training. The aim of this study was to assess the effectiveness of sports massage therapy on reducing post-exercise quadriceps muscle soreness. Methods. A sample of 29 women aged 24-26 years was divided into an experimental group (n = 15 receiving classic sports massage therapy and a control group (n = 14 given no treatment. An exercise session consisting of five sets of deep squat jumps was administered after which lower limb power as assessed via the vertical jump test. Muscle soreness was assessed using the visual analogue scale (VAS and exercise intensity with the Borg Rating of Perceived Exertion Scale. Subsequent measurements of lower limb power and muscle soreness were performed 24, 48, 72 and 96 h after the exercise session. Differences between the measurements were assessed by the Friedman and least significant difference tests while between-group comparisons involved the Mann-Whitney U test. Results. The largest decrease in lower limb power was observed between the first measurement after the exercise session and 24 h later (p < 0.01. The smallest decrease in power was observed in the massage group. The highest levels of muscle soreness were noted 24 h post-exercise in the massage group and 48 h post-exercise in the control group. The experimental group showed a decrease in muscle soreness in each subsequent measurement, with the results close to zero on the VAS 96 h postexercise. Conclusions. Massage therapy quickened recovery and improved muscle efficiency post-exercise and may serve as an effective treatment of muscle soreness. The analgesic effect of massage suggests it should be widely applied in sport, physical therapy and rehabilitation.

  16. Sex and race/ethnic disparities in the cross-sectional association between depressive symptoms and muscle mass: the Multi-ethnic Study of Atherosclerosis.

    Science.gov (United States)

    Remigio-Baker, Rosemay A; Allison, Matthew A; Schreiner, Pamela J; Carnethon, Mercedes R; Nettleton, Jennifer A; Mujahid, Mahasin S; Szklo, Moyses; Crum, Rosa M; Leuotsakos, Jeannie-Marie; Franco, Manuel; Jensky, Nicole; Golden, Sherita Hill

    2015-09-18

    The cross-sectional area of total muscle mass has been reported to decrease by about 40% for those 20-60 years of age. Depressive symptoms may discourage motivation to engage in physical activity such as strength training shown to negate muscle loss. Inflammation related to depressive symptoms may also contribute to muscle atrophy. Physiological differences by sex and race/ethnicity may also modify the association between depression and muscle mass. Evidence on the relationship between depression (or depressive symptoms) and adiposity has been mounting; however, little is known about the depressive symptoms-muscle mass association. We sought to determine the association between elevated depressive symptoms (EDS) and lean muscle mass and whether this varies by sex and race/ethnicity. Evaluating 1605 adults (45-84 years of age) from the Multi-ethnic Study of Atherosclerosis Abdominal Body Composition, Inflammation and Cardiovascular Disease Study, we examined the cross-sectional association between EDS (Center for Epidemiologic Studies for Depression Scale score≥16 and/or antidepressant use) and computed tomography-measured abdominal lean muscle mass using linear regression. Muscles were evaluated as a whole and by functionality (locomotion vs. stabilization/posture). Covariates included height, body mass index, sociodemographics, comorbidities, inflammatory markers and health behaviors (pack-years of smoking, alcohol locomotion compared to men, total intentional exercise, daily caloric intake). Sex and race/ethnicity were assessed as potential modifiers. Statistical significance was at a pdepressive symptoms had 5.9 cm2 lower lean muscle mass for locomotion compared to men without EDS, fully-adjusted (CI=-10.5, -1.4, p=0.011). This was statistically significantly different from the null finding among women (interaction p=0.05). Chinese participants with EDS had 10.2 cm2 lower abdominal lean muscle mass for locomotion compared to those without EDS (fully

  17. Rossi X-Ray Timing Explorer Observations of the First Transient Z Source XTE J1701-462: Shedding New Light on Mass Accretion in Luminous Neutron Star X-Ray Binaries

    Science.gov (United States)

    Homan, Jeroen; van der Klis, Michiel; Wijnands, Rudy; Belloni, Tomaso; Fender, Rob; Klein-Wolt, Marc; Casella, Piergiorgio; Méndez, Mariano; Gallo, Elena; Lewin, Walter H. G.; Gehrels, Neil

    2007-02-01

    We report on the first 10 weeks of RXTE observations of the X-ray transient XTE J1701-462 and conclude that it had all the characteristics of the neutron star Z sources, i.e., the brightest persistent neutron star low-mass X-ray binaries. These include the typical Z-shaped tracks traced out in X-ray color diagrams and the variability components detected in the power spectra, such as kHz QPOs and normal and horizontal branch oscillations. XTE J1701-462 is the first transient Z source and provides unique insights into mass accretion rate (m˙) and luminosity dependencies in neutron star X-ray binaries. As its overall luminosity decreased, we observed a switch between two types of Z source behavior, with the branches of the Z track changing their shape and/or orientation. We interpret this as an extreme case of the more moderate long-term changes seen in the persistent Z sources and suggest that they result from changes in m˙. We also suggest that the Cyg-like Z sources (Cyg X-2, GX 5-1, and GX 340+0) are substantially more luminous (>50%) than the Sco-like Z sources (Sco X-1, GX 17+2, and GX 349+2). Adopting a possible explanation for the behavior of kHz QPOs, which involves a prompt as well as a filtered response to changes in m˙, we further propose that changes in m˙ can explain both movement along the Z track and changes in the shape of the Z track. We discuss some consequences of this and consider the possibility that the branches of the Z will smoothly evolve into the branches observed in X-ray color diagrams of the less luminous atoll sources, although not in a way that was previously suggested.

  18. Changes in the metallicity of gas giant planets due to pebble accretion

    Science.gov (United States)

    Humphries, R. J.; Nayakshin, S.

    2018-06-01

    We run numerical simulations to study the accretion of gas and dust grains on to gas giant planets embedded into massive protoplanetary discs. The outcome is found to depend on the disc cooling rate, planet mass, grain size, and irradiative feedback from the planet. If radiative cooling is efficient, planets accrete both gas and pebbles rapidly, open a gap, and usually become massive brown dwarfs. In the inefficient cooling case, gas is too hot to accrete on to the planet but pebble accretion continues and the planets migrate inward rapidly. Radiative feedback from the planet tends to suppress gas accretion. Our simulations predict that metal enrichment of planets by dust grain accretion inversely correlates with the final planet mass, in accordance with the observed trend in the inferred bulk composition of Solar system and exosolar giant planets. To account for observations, however, as many as ˜30-50 per cent of the dust mass should be in the form of large grains.

  19. Beyond Body Mass Index. Is the Body Cell Mass Index (BCMI) a useful prognostic factor to describe nutritional, inflammation and muscle mass status in hospitalized elderly?: Body Cell Mass Index links in elderly.

    Science.gov (United States)

    Rondanelli, Mariangela; Talluri, Jacopo; Peroni, Gabriella; Donelli, Chiara; Guerriero, Fabio; Ferrini, Krizia; Riggi, Emilia; Sauta, Elisabetta; Perna, Simone; Guido, Davide

    2018-06-01

    The aim of this study was to establish the effectiveness of Body Cell Mass Index (BCMI) as a prognostic index of (mal)nutrition, inflammation and muscle mass status in the elderly. A cross-sectional observational study has been conducted on 114 elderly patients (80 women and 34 men), with mean age equal to 81.07 ± 6.18 years. We performed a multivariate regression model by Structural Equation Modelling (SEM) framework. We detected the effects over a Mini Nutritional Assessment (MNA) stratification, by performing a multi-group multivariate regression model (via SEM) in two MNA nutritional strata, less and bigger (or equal) than 17. BCMI had a significant effect on albumin (β = +0.062, P = 0.001), adjusting for the other predictors of the model as Body Mass Index (BMI), age, sex, fat mass and cognitive condition. An analogous result is maintained in MNAelderly patients. Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  20. Butyryl-cholinesterase is related to muscle mass and strength. A new biomarker to identify elderly subjects at risk of sarcopenia.

    Science.gov (United States)

    Cacciatore, Francesco; Della-Morte, David; Basile, Claudia; Curcio, Francesco; Liguori, Ilaria; Roselli, Mario; Gargiulo, Gaetano; Galizia, Gianluigi; Bonaduce, Domenico; Abete, Pasquale

    2015-01-01

    To determine the relationship between Butyryl-cholinesterase (α-glycoprotein synthesized in the liver, b-CHE) and muscle mass and strength. Muscle mass by bioimpedentiometer and muscle strength by grip strength were evaluated in 337 elderly subjects (mean age: 76.2 ± 6.7 years) admitted to comprehensive geriatric assessment. b-CHE levels were lower in sarcopenic than in nonsarcopenic elderly subjects (p elderly subjects. Thus, b-CHE may be considered to be a fair biomarker for identifying elderly subjects at risk of sarcopenia.

  1. BACK MUSCLES STRENGTH DEVELOPMENT BY MEANS OF INCREASE AND DECREASE OF EFFORT LOAD DURING GIANT SETS IN BODYBUILDING FOR MASSES

    Directory of Open Access Journals (Sweden)

    TIMNEA OLIVIA

    2013-01-01

    Full Text Available Abstract The aim of the study is to highlight methodological issues on the back muscle strength development by combining methodological procedures in masses bodybuilding.Methods. The study was conducted in three stages over a period of two months (March-April 2011, performing three workouts per week, monitoring the effective use of strength exercises to develop back muscles in the same muscle area by means of giant sets during workouts. In this context, we conducted a case study in "Tonik Fitness Club" in Bucharest, applied to two athletes of 28 and 34 years old. We recorded subjects’ evolutions during the training session, using statistical and mathematical method and graphical representation method.Results. The study content highlights the training programs depending on muscle zone and the specific methodological aspects, the weekly training program per muscle groups, the stages of study carrying out, the test and control trials applied in terms of anthropometric measurements and of back muscle strength development, and the application of the methodical procedure of effort load increase and decrease within the giant sets in a training micro-cycle.Discussion. The study focused on the training programs over two months, monitoring statistically the development of back muscle strength through the application of the procedure of effort load increase and decrease during giant sets in bodybuilding for masses. From the analysis of training programs content we noticed that three giant sets of exercises were used, performed in four series; each exercise within the giant sets was applied by means of the procedure of increasing and decreasing effort load. Study results emphasize the anthropometric measurement results: the study subjects have the age mean of 24.75, with a size of 175.2 cm and a weight of 83.75 kg at initial testing and a decrease by 2.12 kg in final testing. Regarding the chest perimeter, the inspiration is averaging 89.5 in initial

  2. Observational diagnostics of accretion on young stars and brown dwarfs

    Science.gov (United States)

    Stelzer, Beate; Argiroffi, Costanza

    I present a summary of recent observational constraints on the accretion properties of young stars and brown dwarfs with focus on the high-energy emission. In their T Tauri phase young stars assemble a few percent of their mass by accretion from a disk. Various observational signatures of disks around pre-main sequence stars and the ensuing accretion process are found in the IR and optical regime: e.g. excess emission above the stellar photosphere, strong and broad emission lines, optical veiling. At high energies evidence for accretion is less obvious, and the X-ray emission from stars has historically been ascribed to magnetically confined coronal plasmas. While being true for the bulk of the emission, new insight obtained from XMM-Newton and Chandra observations has unveiled contributions from accretion and outflow processes to the X-ray emission from young stars. Their smaller siblings, the brown dwarfs, have been shown to undergo a T Tauri phase on the basis of optical/IR observations of disks and measurements of accretion rates. Most re-cently, first evidence was found for X-rays produced by accretion in a young brown dwarf, complementing the suspected analogy between stars and substellar objects.

  3. Dexamethasone and BCAA Failed to Modulate Muscle Mass and mTOR Signaling in GH-Deficient Rats.

    Science.gov (United States)

    Nishida, Hikaru; Ikegami, Ayaka; Kaneko, Chiaki; Kakuma, Hitomi; Nishi, Hisano; Tanaka, Noriko; Aoyama, Michiko; Usami, Makoto; Okimura, Yasuhiko

    2015-01-01

    Branched-chain amino acids (BCAAs) and IGF-I, the secretion of which is stimulated by growth hormone (GH), prevent muscle atrophy. mTOR plays a pivotal role in the protective actions of BCAA and IGF-1. The pathway by which BCAA activates mTOR is different from that of IGF-1, which suggests that BCAA and GH work independently. We tried to examine whether BCAA exerts a protective effect against dexamethasone (Dex)-induced muscle atrophy independently of GH using GH-deficient spontaneous dwarf rats (SDRs). Unexpectedly, Dex did not induce muscle atrophy assessed by the measurement of cross-sectional area (CSA) of the muscle fibers and did not increase atrogin-1, MuRF1 and REDD1 expressions, which are activated during protein degradation. Glucocorticoid (GR) mRNA levels were higher in SDRs compared to GH-treated SDRs, indicating that the low expression of GR is not the reason of the defect of Dex's action in SDRs. BCAA did not stimulate the phosphorylation of p70S6K or 4E-BP1, which stimulate protein synthesis. BCAA did not decrease the mRNA level of atrogin-1 or MuRF1. These findings suggested that Dex failed to modulate muscle mass and that BCAA was unable to activate mTOR in SDRs because these phosphorylations of p70S6K and 4E-BP1 and the reductions of these mRNAs are regulated by mTOR. In contrast, after GH supplementation, these responses to Dex were normalized and muscle fiber CSA was decreased by Dex. BCAA prevented the Dex-induced decrease in CSA. BCAA increased the phosphorylation of p70S6K and decreased the Dex-induced elevations of atrogin-1 and Bnip3 mRNAs. However, the amount of mTORC1 components including mTOR was not decreased in the SDRs compared to the normal rats. These findings suggest that GH increases mTORC1 activity but not its content to recover the action of BCAA in SDRs and that GH is required for actions of Dex and BCAA in muscles.

  4. Dexamethasone and BCAA Failed to Modulate Muscle Mass and mTOR Signaling in GH-Deficient Rats.

    Directory of Open Access Journals (Sweden)

    Hikaru Nishida

    Full Text Available Branched-chain amino acids (BCAAs and IGF-I, the secretion of which is stimulated by growth hormone (GH, prevent muscle atrophy. mTOR plays a pivotal role in the protective actions of BCAA and IGF-1. The pathway by which BCAA activates mTOR is different from that of IGF-1, which suggests that BCAA and GH work independently. We tried to examine whether BCAA exerts a protective effect against dexamethasone (Dex-induced muscle atrophy independently of GH using GH-deficient spontaneous dwarf rats (SDRs. Unexpectedly, Dex did not induce muscle atrophy assessed by the measurement of cross-sectional area (CSA of the muscle fibers and did not increase atrogin-1, MuRF1 and REDD1 expressions, which are activated during protein degradation. Glucocorticoid (GR mRNA levels were higher in SDRs compared to GH-treated SDRs, indicating that the low expression of GR is not the reason of the defect of Dex's action in SDRs. BCAA did not stimulate the phosphorylation of p70S6K or 4E-BP1, which stimulate protein synthesis. BCAA did not decrease the mRNA level of atrogin-1 or MuRF1. These findings suggested that Dex failed to modulate muscle mass and that BCAA was unable to activate mTOR in SDRs because these phosphorylations of p70S6K and 4E-BP1 and the reductions of these mRNAs are regulated by mTOR. In contrast, after GH supplementation, these responses to Dex were normalized and muscle fiber CSA was decreased by Dex. BCAA prevented the Dex-induced decrease in CSA. BCAA increased the phosphorylation of p70S6K and decreased the Dex-induced elevations of atrogin-1 and Bnip3 mRNAs. However, the amount of mTORC1 components including mTOR was not decreased in the SDRs compared to the normal rats. These findings suggest that GH increases mTORC1 activity but not its content to recover the action of BCAA in SDRs and that GH is required for actions of Dex and BCAA in muscles.

  5. Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes

    DEFF Research Database (Denmark)

    Pedersen, Maria; Bruunsgaard, Helle; Weis, Nina

    2003-01-01

    The purpose of the current study was to test the hypothesis that an altered fat distribution in elderly healthy subjects and in patients with type-2 diabetes contributes to high circulating levels of interleukin (IL)-6 and tumor necrotic factor (TNF)-alpha, which secondly is related to lower muscle...... mass. Twenty young controls, (20-35 yr), 20 healthy elderly subjects (65-80 yr) and 16 elderly patients with type 2 diabetes (65-80 yr) were included in a cross sectional study. Plasma levels of TNF-alpha and IL-6 were measured after an overnight fast. Dual-energy X-ray absorptiometry and total body...... to lower ASM and BCM in elderly men both in a univariate regression analysis and a multivariate regression analysis. In conclusion, high plasma levels of TNF-alpha and IL-6 in elderly healthy people and in patients with type 2 diabetes are associated with increased truncal fat mass, suggesting...

  6. Hypertrophy Stimulation at the Onset of Type I Diabetes Maintains the Soleus but Not the EDL Muscle Mass in Wistar Rats

    Directory of Open Access Journals (Sweden)

    Marco A. S. Fortes

    2017-10-01

    Full Text Available Diabetes mellitus induces a reduction in skeletal muscle mass and strength. Strength training is prescribed as part of treatment since it improves glycemic control and promotes increase of skeletal muscle mass. The mechanisms involved in overload-induced muscle hypertrophy elicited at the establishment of the type I diabetic state was investigated in Wistar rats. The purpose was to examine whether the overload-induced hypertrophy can counteract the hypotrophy associated to the diabetic state. The experiments were performed in oxidative (soleus or glycolytic (EDL muscles. PI3K/Akt/mTOR protein synthesis pathway was evaluated 7 days after overload-induced hypertrophy of soleus and of EDL muscles. The mRNA expression of genes associated with different signaling pathways that control muscle hypertrophy was also evaluated: mechanotransduction (FAK, Wnt/β-catenin, myostatin, and follistatin. The soleus and EDL muscles when submitted to overload had similar hypertrophic responses in control and diabetic animals. The increase of absolute and specific twitch and tetanic forces had the same magnitude as muscle hypertrophic response. Hypertrophy of the EDL muscle from diabetic animals mostly involved mechanical loading-stimulated PI3K/Akt/mTOR pathway besides the reduced activation of AMP-activated protein kinase (AMPK and decrease of myostatin expression. Hypertrophy was more pronounced in the soleus muscle of diabetic animals due to a more potent activation of rpS6 and increased mRNA expression of insulin-like growth factor-1 (IGF-1, mechano-growth factor (MGF and follistatin, and decrease of myostatin, MuRF-1 and atrogin-1 contents. The signaling changes enabled the soleus muscle mass and force of the diabetic rats to reach the values of the control group.

  7. Hypertrophy Stimulation at the Onset of Type I Diabetes Maintains the Soleus but Not the EDL Muscle Mass in Wistar Rats

    Science.gov (United States)

    Fortes, Marco A. S.; Scervino, Maria V. M.; Marzuca-Nassr, Gabriel N.; Vitzel, Kaio F.; da Justa Pinheiro, Carlos H.; Curi, Rui

    2017-01-01

    Diabetes mellitus induces a reduction in skeletal muscle mass and strength. Strength training is prescribed as part of treatment since it improves glycemic control and promotes increase of skeletal muscle mass. The mechanisms involved in overload-induced muscle hypertrophy elicited at the establishment of the type I diabetic state was investigated in Wistar rats. The purpose was to examine whether the overload-induced hypertrophy can counteract the hypotrophy associated to the diabetic state. The experiments were performed in oxidative (soleus) or glycolytic (EDL) muscles. PI3K/Akt/mTOR protein synthesis pathway was evaluated 7 days after overload-induced hypertrophy of soleus and of EDL muscles. The mRNA expression of genes associated with different signaling pathways that control muscle hypertrophy was also evaluated: mechanotransduction (FAK), Wnt/β-catenin, myostatin, and follistatin. The soleus and EDL muscles when submitted to overload had similar hypertrophic responses in control and diabetic animals. The increase of absolute and specific twitch and tetanic forces had the same magnitude as muscle hypertrophic response. Hypertrophy of the EDL muscle from diabetic animals mostly involved mechanical loading-stimulated PI3K/Akt/mTOR pathway besides the reduced activation of AMP-activated protein kinase (AMPK) and decrease of myostatin expression. Hypertrophy was more pronounced in the soleus muscle of diabetic animals due to a more potent activation of rpS6 and increased mRNA expression of insulin-like growth factor-1 (IGF-1), mechano-growth factor (MGF) and follistatin, and decrease of myostatin, MuRF-1 and atrogin-1 contents. The signaling changes enabled the soleus muscle mass and force of the diabetic rats to reach the values of the control group. PMID:29123487

  8. Synchrotron radiation from spherically accreting black holes

    International Nuclear Information System (INIS)

    Ipser, J.R.; Price, R.H.

    1982-01-01

    Spherical accretion onto a Schwartzchild black hole, of gas with frozen-in magnetic field, is studied numerically and analytically for a range of hole masses and accretion rates in which synchrotron emission is the dominant radiative mechanism. At small radii the equipartition of magnetic, kinetic, and gravitational energy is assumed to apply, and the gas is heated by dissipation of infalling magnetic energy, turbulent energy, etc. The models can be classified into three types: (a) synchrotron cooling negligible, (b) synchrotron cooling important but synchrotron self-absorption negligible, (c) synchrotron cooling and self-absorption important. In the first case gas temperatures become very high near the horizon but luminosity efficiencies (luminosity/mass-energy accretion rate) are low. In cases (b) and (c) the gas flow near the horizon is essentially isothermal and luminosity efficiencies are fairly high. The analysis and results for the isothermal cases (b) and (c) are valid only for moderate dissipative heating and synchrotron self-absorption. If self-absorption is very strong or if dissipated energy is comparable to infall energy, Comptonization effects, not included in the analysis, become important

  9. Thermal Comptonization in standard accretion disks

    International Nuclear Information System (INIS)

    Maraschi, L.; Molendi, S.

    1990-01-01

    The standard model of an accretion disk is considered. The temperature in the inner region is computed assuming that the radiated power derives from Comptonized photons, produced in a homogeneous single-temperature plasma, supported by radiation pressure. The photon production mechanisms are purely thermal, including ion-electron bremsstrahlung, bound-free and bound-bound processes, and e-e bremsstrahlung. Pair production is not included, which limits the validity of the treatment to kT less than 60 keV. Three different approximations for the effects of Comptonization on the energy loss are used, yielding temperatures which agree within 50 percent. The maximum temperature is very sensitive to the accretion rate and viscosity parameters, ranging, for a 10 to the 8th solar mass black hole, between 0.1 and 50 keV for m between 0.1 and 1 and alpha between 0.1 and 1 and, for a 10-solar-mass black hole, between 0.6 and 60 keV for m between 0.1 and 0.9 and alpha between 0.1 and 0.5. For high viscosity and accretion rates, the emission spectra show a flat component following a peak corresponding to the temperature of the innermost optically thick annulus. 28 refs

  10. The formation of stars by gravitational collapse rather than competitive accretion

    Science.gov (United States)

    Krumholz, Mark R.; McKee, Christopher F.; Klein, Richard I.

    2005-11-01

    There are two dominant models of how stars form. Under gravitational collapse, star-forming molecular clumps, of typically hundreds to thousands of solar masses (Msolar), fragment into gaseous cores that subsequently collapse to make individual stars or small multiple systems. In contrast, competitive accretion theory suggests that at birth all stars are much smaller than the typical stellar mass (~0.5Msolar), and that final stellar masses are determined by the subsequent accretion of unbound gas from the clump. Competitive accretion models interpret brown dwarfs and free-floating planets as protostars ejected from star-forming clumps before they have accreted much mass; key predictions of this model are that such objects should lack disks, have high velocity dispersions, form more frequently in denser clumps, and that the mean stellar mass should vary within the Galaxy. Here we derive the rate of competitive accretion as a function of the star-forming environment, based partly on simulation, and determine in what types of environments competitive accretion can occur. We show that no observed star-forming region can undergo significant competitive accretion, and that the simulations that show competitive accretion do so because the assumed properties differ from those determined by observation. Our result shows that stars form by gravitational collapse, and explains why observations have failed to confirm predictions of the competitive accretion model.

  11. Cold gas accretion in galaxies

    NARCIS (Netherlands)

    Sancisi, Renzo; Fraternali, Filippo; Oosterloo, Tom; van der Hulst, Thijs

    Evidence for the accretion of cold gas in galaxies has been rapidly accumulating in the past years. HI observations of galaxies and their environment have brought to light new facts and phenomena which are evidence of ongoing or recent accretion: (1) A large number of galaxies are accompanied by

  12. Volatile accretion history of the Earth.

    Science.gov (United States)

    Wood, B J; Halliday, A N; Rehkämper, M

    2010-10-28

    It has long been thought that the Earth had a protracted and complex history of volatile accretion and loss. Albarède paints a different picture, proposing that the Earth first formed as a dry planet which, like the Moon, was devoid of volatile constituents. He suggests that the Earth's complement of volatile elements was only established later, by the addition of a small veneer of volatile-rich material at ∼100 Myr (here and elsewhere, ages are relative to the origin of the Solar System). Here we argue that the Earth's mass balance of moderately volatile elements is inconsistent with Albarède's hypothesis but is well explained by the standard model of accretion from partially volatile-depleted material, accompanied by core formation.

  13. Molecular regulation of high muscle mass in developing Blonde d'Aquitaine cattle foetuses

    Directory of Open Access Journals (Sweden)

    Isabelle Cassar-Malek

    2017-10-01

    Full Text Available The Blonde d'Aquitaine (BA is a French cattle breed with enhanced muscularity, partly attributable to a MSTN mutation. The BA m. Semitendinosus has a faster muscle fibre isoform phenotype comprising a higher proportion of fast type IIX fibres compared to age-matched Charolais (CH. To better understand the molecular network of modifications in BA compared to CH muscle, we assayed the transcriptomes of the m. Semitendinosus at 110, 180, 210 and 260 days postconception (dpc. We used a combination of differential expression (DE and regulatory impact factors (RIF to compare and contrast muscle gene expression between the breeds. Prominently developmentally regulated genes in both breeds reflected the replacement of embryonic myosin isoforms (MYL4, MYH3 with adult isoforms (MYH1 and the upregulation of mitochondrial metabolism (CKMT2, AGXT2L1 in preparation for birth. However, the transition to a fast, glycolytic muscle phenotype in the MSTN mutant BA is detectable through downregulation of various slow twitch subunits (TNNC1, MYH7, TPM3, CSRP3 beyond 210 dpc, and a small but consistent genome-wide reduction in mRNA encoding the mitoproteome. Across the breeds, NRIP2 is the regulatory gene possessing a network change most similar to that of MSTN.

  14. Influence of blood flow occlusion on the development of peripheral and central fatigue during small muscle mass handgrip exercise.

    Science.gov (United States)

    Broxterman, R M; Craig, J C; Smith, J R; Wilcox, S L; Jia, C; Warren, S; Barstow, T J

    2015-09-01

    Critical power represents an important threshold for neuromuscular fatigue development and may, therefore, dictate intensities for which exercise tolerance is determined by the magnitude of fatigue accrued. Peripheral fatigue appears to be constant across O2 delivery conditions for large muscle mass exercise, but this consistency is equivocal for smaller muscle mass exercise. We sought to determine the influence of blood flow occlusion during handgrip exercise on neuromuscular fatigue development and to examine the relationship between neuromuscular fatigue development and W '. Blood flow occlusion influenced the development of both peripheral and central fatigue, thus providing further evidence that the magnitude of peripheral fatigue is not constant across O2 delivery conditions for small muscle mass exercise. W ' appears to be related to the magnitude of fatigue accrued during exercise, which may explain the reported consistency of intramuscular metabolic perturbations and work performed for severe-intensity exercise. The influence of the muscle metabolic milieu on peripheral and central fatigue is currently unclear. Moreover, the relationships between peripheral and central fatigue and the curvature constant (W ') have not been investigated. Six men (age: 25 ± 4 years, body mass: 82 ± 10 kg, height: 179 ± 4 cm) completed four constant power handgrip tests to exhaustion under conditions of control exercise (Con), blood flow occlusion exercise (Occ), Con with 5 min post-exercise blood flow occlusion (Con + Occ), and Occ with 5 min post-exercise blood flow occlusion (Occ + Occ). Neuromuscular fatigue measurements and W ' were obtained for each subject. Each trial resulted in significant peripheral and central fatigue. Significantly greater peripheral (79.7 ± 5.1% vs. 22.7 ± 6.0%) and central (42.6 ± 3.9% vs. 4.9 ± 2.0%) fatigue occurred for Occ than for Con. In addition, significantly greater peripheral (83.0 ± 4.2% vs. 69.0 ± 6.2%) and central

  15. Snow accretion on overhead wires

    Energy Technology Data Exchange (ETDEWEB)

    Sakamoto, Y. [Meteorological Research Inst. for Technology Co. Ltd., Tokyo (Japan); Tachizaki, S.; Sudo, N. [Tohoku Electric Power Co. Ltd., Miyagi (Japan)

    2005-07-01

    Wet snow accretion can cause extensive damage to transmission systems. This paper reviewed some of the difficulties faced by researchers in the study of wet snow accretion on overhead lines in Japan. The study of snow accretion phenomena is complicated by the range of phase changes in water. Snowflakes produced in an upper atmospheric layer with a temperature below freezing do not melt when they go through a lower atmospheric layer with a temperature above freezing, but are in a mixed state of solid and liquid due to the latent heat of melting. The complicated properties of water make studies of snow accretion difficult, as well as the fact that snow changes its physical properties rapidly, due to the effects of ambient temperature, rainfall, and solar radiation. The adhesive forces that cause snow accretion include freezing; bonding through freezing; sintering; condensation and freezing of vapor in the air; mechanical intertwining of snowflakes; capillary action due to liquids; coherent forces between ice particles and water formed through the metamorphosis of snowflakes. In addition to these complexities, differences in laboratory room environments and natural snow environments can also pose difficulties for researchers. Equations describing the relationship between the density of accreted snow and the meteorological parameters involved were presented, as well as empirical equations which suggested that snow accretion efficiency has a dependency on air temperature. An empirical model for estimating snow loads in Japan was outlined, as well as various experiments observing show shedding. Correlations for wet snow accretion included precipitation intensity; duration of precipitation; air temperature; wind speed and wind direction in relation to the overhead line. Issues concerning topography and wet snow accretion were reviewed. It was concluded that studies of snow accretion will benefit by the collection of data in each matrix of the relevant parameters. 12 refs

  16. Hot accreting white dwarfs in the quasi-static approximation

    International Nuclear Information System (INIS)

    Iben, I. Jr.

    1982-01-01

    Properties of white dwarfs which are accreting hydrogen-rich matter at rates in the range 1.5 x 10 -9 to 2.5 x 10 -7 M/sub sun/ yr -1 are investigated in several approximations. Steady-burning models, in which matter is processed through nuclear-burning shells as rapidly as it is accreted, provide a framework for understanding the properties of models in which thermal pulses induced by hydrogen burning and helium burning are allowed to occur. In these latter models, the underlying carbon-oxygen core is chosen to be in a cycle-averaged steady state with regard to compressional heating and neutrino losses. Several of these models are evolved in the quasi-static approximation. Combining results obtained in the steady-burning approximation with those obtained in the quasi-static approximation, expressions are obtained for estimating, as functions of accretion rate and white dwarf mass, the thermal pulse recurrence period and the duration of hydrogen-burning phases. The time spent by an accreting model burning hydrogen as a large star of giant dimensions versus time spent burning hydrogen as a hot dwarf is also estimated as a function of model mass and accretion rate. Finally, suggestions for detecting observational counterparts of the theoretical models and suggestions for further theoretical investigations are offered. Subject headings: stars: accretion: stars: interiors: stars: novae: stars: symbiotic: stars: white dwarfs

  17. Magnetospheres of accreting compact objects in binary systems

    International Nuclear Information System (INIS)

    Aly, J.J.

    1985-09-01

    Bright pulsating X-ray sources (X-ray pulsars, AM Her stars,...) have been identified as strongly magnetized compact objects accreting matter from a binary companion. We give here a summary of some of the work which has been recently done to try to understand the interaction between the magnetic field of the compact object and the matter around. We examine in turn the models describing the interaction of the field with: i) a spherically symmetric accretion flow; ii) a thin keplerian accretion disk; iii) the companion itself. In all these cases, we pay particular attention to the following problems: i) how the external plasma interacting with the magnetosphere can get mixed with the field; ii) by which mechanism the magnetic field controls the mass-momentum-energy exchanges between the two stars. In conclusion, we compare the magnetosphere of an accreting compact object with that one of a planet [fr

  18. Analogue Hawking radiation from astrophysical black-hole accretion

    International Nuclear Information System (INIS)

    Das, Tapas K

    2004-01-01

    We show that spherical accretion onto astrophysical black holes can be considered as a natural example of an analogue system. We provide, for the first time, an exact analytical scheme for calculating the analogue Hawking temperature and surface gravity for general relativistic accretion onto astrophysical black holes. Our calculation may bridge the gap between the theory of transonic astrophysical accretion and the theory of analogue Hawking radiation. We show that the domination of the analogue Hawking temperature over the actual Hawking temperature may be a real astrophysical phenomenon, though observational tests of this fact will at best be difficult and at worst might prove to be impossible. We also discuss the possibilities of the emergence of analogue white holes around astrophysical black holes. Our calculation is general enough to accommodate accreting black holes with any mass

  19. Accretion of a ghost condensate by black holes

    International Nuclear Information System (INIS)

    Frolov, Andrei V.

    2004-01-01

    The intent of this paper is to point out that the accretion of a ghost condensate by black holes could be extremely efficient. We analyze steady-state spherically symmetric flows of the ghost fluid in the gravitational field of a Schwarzschild black hole and calculate the accretion rate. Unlike minimally coupled scalar field or quintessence, the accretion rate is set not by the cosmological energy density of the field, but by the energy scale of the ghost condensate theory. If hydrodynamical flow is established, it could be as high as a tenth of a solar mass per second for 10 MeV scale ghost condensate accreting onto a stellar-sized black hole, which puts serious constraints on the parameters of the ghost condensate model

  20. Impact of low skeletal muscle mass and density on short and long-term outcome after resection of stage I-III colorectal cancer.

    Science.gov (United States)

    van Vugt, Jeroen L A; Coebergh van den Braak, Robert R J; Lalmahomed, Zarina S; Vrijland, Wietske W; Dekker, Jan W T; Zimmerman, David D E; Vles, Wouter J; Coene, Peter-Paul L O; IJzermans, Jan N M

    2018-06-06

    Preoperative low skeletal muscle mass and density are associated with increased postoperative morbidity in patients undergoing curative colorectal cancer (CRC) surgery. However, the long-term effects of low skeletal muscle mass and density remain uncertain. Patients with stage I-III CRC undergoing surgery, enrolled in a prospective observational cohort study, were included. Skeletal muscle mass and density were measured on CT. Patients with high and low skeletal muscle mass and density were compared regarding postoperative complications, disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS). In total, 816 patients (53.9% males, median age 70) were included; 50.4% had low skeletal muscle mass and 64.1% low density. The severe postoperative complication rate was significantly higher in patients with low versus high skeletal muscle and density (20.9% versus 13.6%, p = 0.006; 20.0% versus 11.8%, p = 0.003). Low skeletal muscle mass (OR 1.91, p = 0.018) and density (OR 1.87, p = 0.045) were independently associated with severe postoperative complications. Ninety-day mortality was higher in patients with low skeletal muscle mass and density compared with patients with high skeletal muscle mass and density (3.6% versus 1.7%, p = 0.091; 3.4% versus 1.0%, p = 0.038). No differences in DFS were observed. After adjustment for covariates such as age and comorbidity, univariate differences in OS and CSS diminished. Low skeletal muscle mass and density are associated with short-term, but not long-term, outcome in patients undergoing CRC surgery. These findings recommend putting more emphasis on preoperative management of patients at risk for surgical complications, but do not support benefit for long-term outcome. Copyright © 2018 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

  1. FILAMENTARY ACCRETION FLOWS IN THE EMBEDDED SERPENS SOUTH PROTOCLUSTER

    Energy Technology Data Exchange (ETDEWEB)

    Kirk, Helen; Myers, Philip C.; Bourke, Tyler L. [Radio and Geoastronomy Division, Harvard Smithsonian Center for Astrophysics, MS-42, Cambridge, MA, 02138 (United States); Gutermuth, Robert A.; Wilson, Grant W. [Department of Astronomy, University of Massachusetts Amherst, Amherst, MA 01003 (United States); Hedden, Abigail, E-mail: kirkh@mcmaster.ca [Army Research Labs, Adelphi, MD 20783 (United States)

    2013-04-01

    One puzzle in understanding how stars form in clusters is the source of mass-is all of the mass in place before the first stars are born, or is there an extended period when the cluster accretes material which can continuously fuel the star formation process? We use a multi-line spectral survey of the southern filament associated with the Serpens South embedded cluster-forming region in order to determine if mass is accreting from the filament onto the cluster, and whether the accretion rate is significant. Our analysis suggests that material is flowing along the filament's long axis at a rate of {approx}30 M{sub Sun} Myr{sup -1} (inferred from the N{sub 2}H{sup +} velocity gradient along the filament), and radially contracting onto the filament at {approx}130 M{sub Sun} Myr{sup -1} (inferred from HNC self-absorption). These accretion rates are sufficient to supply mass to the central cluster at a similar rate to the current star formation rate in the cluster. Filamentary accretion flows may therefore be very important in the ongoing evolution of this cluster.

  2. Hydrogen and helium shell burning during white dwarf accretion

    Science.gov (United States)

    Cui, Xiao; Meng, Xiang-Cun; Han, Zhan-Wen

    2018-05-01

    Type Ia supernovae (SNe Ia) are believed to be thermonuclear explosions of carbon oxygen (CO) white dwarfs (WDs) with masses close to the Chandrasekhar mass limit. How a CO WD accretes matter and grows in mass to this limit is not well understood, hindering our understanding of SN Ia explosions and the reliability of using SNe Ia as a cosmological distance indicator. In this work, we employed the stellar evolution code MESA to simulate the accretion process of hydrogen-rich material onto a 1.0 M ⊙ CO WD at a high rate (over the Eddington limit) of 4.3 × 10‑7 M ⊙ yr‑1. The simulation demonstrates the characteristics of the double shell burning on top of the WD, with a hydrogen shell burning on top of a helium burning shell. The results show that helium shell burning is not steady (i.e. it flashes). Flashes from the helium shell are weaker than those in the case of accretion of helium-rich material onto a CO WD. The carbon to oxygen mass ratio resulting from the helium shell burning is higher than what was previously thought. Interestingly, the CO WD growing due to accretion has an outer part containing a small fraction of helium in addition to carbon and oxygen. The flashes become weaker and weaker as the accretion continues.

  3. Gravitational radiation and gamma-ray bursts from accreting neutron stars

    International Nuclear Information System (INIS)

    Mosquera Cuesta, H.J.; Araujo, J.C.N. de; Aguiar, O.D.; Horvath, J.E.

    2000-01-01

    It is well known that hydrodynamic instabilities can be induced in rapidly rotating low magnetic field neutron stars, which accrete mass from a companion in both high and low mass X-ray binaries. (author)

  4. Massive star formation by accretion. II. Rotation: how to circumvent the angular momentum barrier?

    Science.gov (United States)

    Haemmerlé, L.; Eggenberger, P.; Meynet, G.; Maeder, A.; Charbonnel, C.; Klessen, R. S.

    2017-06-01

    Context. Rotation plays a key role in the star-formation process, from pre-stellar cores to pre-main-sequence (PMS) objects. Understanding the formation of massive stars requires taking into account the accretion of angular momentum during their PMS phase. Aims: We study the PMS evolution of objects destined to become massive stars by accretion, focusing on the links between the physical conditions of the environment and the rotational properties of young stars. In particular, we look at the physical conditions that allow the production of massive stars by accretion. Methods: We present PMS models computed with a new version of the Geneva Stellar Evolution code self-consistently including accretion and rotation according to various accretion scenarios for mass and angular momentum. We describe the internal distribution of angular momentum in PMS stars accreting at high rates and we show how the various physical conditions impact their internal structures, evolutionary tracks, and rotation velocities during the PMS and the early main sequence. Results: We find that the smooth angular momentum accretion considered in previous studies leads to an angular momentum barrier and does not allow the formation of massive stars by accretion. A braking mechanism is needed in order to circumvent this angular momentum barrier. This mechanism has to be efficient enough to remove more than two thirds of the angular momentum from the inner accretion disc. Due to the weak efficiency of angular momentum transport by shear instability and meridional circulation during the accretion phase, the internal rotation profiles of accreting stars reflect essentially the angular momentum accretion history. As a consequence, careful choice of the angular momentum accretion history allows circumvention of any limitation in mass and velocity, and production of stars of any mass and velocity compatible with structure equations.

  5. Creation of a contusion injury in rabbit skeletal muscle using a drop-mass technique

    Directory of Open Access Journals (Sweden)

    Margaret N. Deane

    2013-08-01

    Full Text Available This study reports our experience in developing a simple, minor injury. After reviewing the literature, a ‘drop-mass’ method was selected where a 201 g, elongated oval-shaped weight was dropped up to 15 times through a 1 m tube onto the left vastus lateralis of New Zealand white rabbits. To determine the extent of injury and degree of healing, biopsies were obtained six days after injury from the healing vastus lateralis of each animal. The tissue was fixed in formal saline, embedded in wax, cut and stained with haematoxylin and eosin (H&E and phosphotungstic acid haematoxylin (PTAH and examined by light microscopy (LM. The ‘optimal’ injury was created after seven drops, where quite severe, mild and moderately severe trauma was caused to muscle in the juxta-bone, mid and sub-dermal regions respectively. In each region, the muscle exhibited features of healing six days after injury. The ‘drop-mass’ technique appears to cause a contusion within a single muscle of at least three degrees of severity. This previously unreported observation is of particular importance to other researchers wishing to investigate contusion injury in other animal models.

  6. The effect of protein intake and resistance training on muscle mass in acutely ill old medical patients - A randomized controlled trial

    DEFF Research Database (Denmark)

    Buhl, Sussi F; Andersen, Aino L; Andersen, Jens Rikardt

    2016-01-01

    admission and a daily protein supplement (18.8 g protein) and resistance training 3 times per week the 12 weeks following discharge. Muscle mass was assessed by Dual-energy X-ray Absorptiometry. Muscle strength was assessed by Hand Grip Strength and Chair Stand Test. Functional ability was assessed...... mass (unadjusted: β-coefficient = -1.28 P = 0.32, adjusted for gender: β-coefficient = -0.02 P = 0.99, adjusted for baseline lean mass: β-coefficient = -0.31 P = 0.80). The de Morton Mobility Index significantly increased in the Control Group (β-coefficient = -11.43 CI: 0.72-22.13, P = 0.04). No other...... differences were found. CONCLUSION: No significant effect on muscle mass was observed in this group of acutely ill old medical patients. High compliance was achieved with the dietary intervention, but resistance training was challenging. Clinical trials identifier NCT02077491....

  7. Age-related differences in lean mass, protein synthesis and skeletal muscle markers of proteolysis after bed rest and exercise rehabilitation.

    Science.gov (United States)

    Tanner, Ruth E; Brunker, Lucille B; Agergaard, Jakob; Barrows, Katherine M; Briggs, Robert A; Kwon, Oh Sung; Young, Laura M; Hopkins, Paul N; Volpi, Elena; Marcus, Robin L; LaStayo, Paul C; Drummond, Micah J

    2015-09-15

    Bed rest-induced muscle loss and impaired muscle recovery may contribute to age-related sarcopenia. It is unknown if there are age-related differences in muscle mass and muscle anabolic and catabolic responses to bed rest. A secondary objective was to determine if rehabilitation could reverse bed rest responses. Nine older and fourteen young adults participated in a 5-day bed rest challenge (BED REST). This was followed by 8 weeks of high intensity resistance exercise (REHAB). Leg lean mass (via dual-energy X-ray absorptiometry; DXA) and strength were determined. Muscle biopsies were collected during a constant stable isotope infusion in the postabsorptive state and after essential amino acid (EAA) ingestion on three occasions: before (PRE), after bed rest and after rehabilitation. Samples were assessed for protein synthesis, mTORC1 signalling, REDD1/2 expression and molecular markers related to muscle proteolysis (MURF1, MAFBX, AMPKα, LC3II/I, Beclin1). We found that leg lean mass and strength decreased in older but not younger adults after bedrest (P protein synthesis increased before bed rest in both age groups (P protein synthesis rates and increased MAFBX mRNA, p-AMPKα and the LC3II/I ratio (P protein synthesis and a marginal increase in proteolytic markers. Finally, rehabilitation restored bed rest-induced deficits in lean mass and strength in older adults. © 2015 The Authors. The Journal of Physiology © 2015 The Physiological Society.

  8. Effects of Eight Months of Whole-Body Vibration Training on the Muscle Mass and Functional Capacity of Elderly Women.

    Science.gov (United States)

    Santin-Medeiros, Fernanda; Rey-López, Juan P; Santos-Lozano, Alejandro; Cristi-Montero, Carlos S; Garatachea Vallejo, Nuria

    2015-07-01

    Few intervention studies have used whole-body vibration (WBV) training in the elderly, and there is inconclusive evidence about its health benefits. We examined the effect of 8 months of WBV training on muscle mass and functional capacity in elderly women. A total of 37 women (aged 82.4 ± 5.7 years) voluntarily participated in this study. Subjects were randomly assigned to a vibration group (n = 19) or a control group (n = 18). The vibration group trained on a vertical vibration platform twice a week. The control group was requested not to change their habitual lifestyle. The quadriceps femoris muscle cross-sectional area was determined by magnetic resonance imaging. All participants were evaluated by a battery of tests (Senior Fitness Test) to determine their functional capacity, as well as handgrip strength and balance/gait. General linear repeated-measure analysis of variance (group by time) was performed to examine the effect of the intervention on the outcomes variables. After 8 months, nonstatistically significant differences in the quadriceps CSA (pre-training: 8,516.16 ± 1,271.78 mm² and post-training: 8,671.63 ± 1,389.03 mm²) (p > 0.05) were found in the WBV group (Cohen's d: -0.12), whereas the CON group significantly decreased muscle mass (pre-training: 9,756.18 ± 1,420.07 mm² and post-training: 9,326.82 ± 1,577.53 mm²), with moderate effect size evident (Cohen's d: 0.29). In both groups, no changes were observed in the functional capacity, handgrip strength and balance/gait. The WBV training could prevent the loss of quadriceps CSA in elderly women.

  9. Alternate Mediterranean diet score is positively associated with skeletal muscle mass index in middle-aged adults.

    Science.gov (United States)

    Tian, Hui-Yuan; Qiu, Rui; Jing, Li-Peng; Chen, Zhan-Yong; Chen, Geng-Dong; Chen, Yu-Ming

    2017-04-01

    Researches have suggested Mediterranean diet might lower the risk of chronic diseases, but data on skeletal muscle mass (SMM) are limited. This community-based cross-sectional study examined the association between the alternate Mediterranean diet score (aMDS) and SMM in 2230 females and 1059 males aged 40-75 years in Guangzhou, China. General information and habitual dietary information were assessed in face-to-face interviews conducted during 2008-2010 and 3 years later. The aMDS was calculated by summing the dichotomous points for the items of higher intakes of whole grain, vegetables, fruits, legumes, nuts, fish and ratio of MUFA:SFA, lower red meat and moderate ethanol consumption. The SMM of the whole body, limbs, arms and legs were measured using dual-energy X-ray absorptiometry during 2011-2013. After adjusting for potential covariates, higher aMDS was positively associated with skeletal muscle mass index (SMI, SMM/height2, kg/m2) at all of the studied sites in males (all P trend0·05). Age-stratified analyses showed that the favourable associations tended to be more pronounced in the younger subjects aged less than the medians of 59·2 and 62·2 years in females and males (P interaction>0·10). In conclusion, the aMDS shows protective associations with SMM in Chinese adults, particularly in male and younger subjects.

  10. Feasibility of resistance training in adult McArdle patients: Clinical outcomes and muscle strength and mass benefits

    Directory of Open Access Journals (Sweden)

    Alfredo eSantalla

    2014-12-01

    Full Text Available We analyzed the effects of a 4-month resistance (weight lifting training program followed by a 2-month detraining period in 7 adult McArdle patients (5 female on: muscle mass (assessed by DXA, strength, serum creatine kinase (CK activity and clinical severity. Adherence to training was ≥ 84% in all patients and no major contraindication or side effect was noted during the training or strength assessment sessions. The training program had a significant impact on total and lower extremities’ lean mass (P0.05 was noted for baseline or post strength assessment values of serum CK activity, which remained essentially within the range reported in our laboratory for McArdle patients. All the patients changed to a lower severity class with training, such that none of them were in the highest disease severity class (3 after the intervention and, as such, they did not have fixed muscle weakness after training. Clinical improvements were retained, in all but one patient, after detraining, such that after detraining all patients were classed as class 1 for

  11. Similar muscles contribute to horizontal and vertical acceleration of center of mass in forward and backward walking: implications for neural control

    Science.gov (United States)

    Jansen, Karen; De Groote, Friedl; Massaad, Firas; Meyns, Pieter; Jonkers, Ilse

    2012-01-01

    Leg kinematics during backward walking (BW) are very similar to the time-reversed kinematics during forward walking (FW). This suggests that the underlying muscle activation pattern could originate from a simple time reversal, as well. Experimental electromyography studies have confirmed that this is the case for some muscles. Furthermore, it has been hypothesized that muscles showing a time reversal should also exhibit a reversal in function [from accelerating the body center of mass (COM) to decelerating]. However, this has not yet been verified in simulation studies. In the present study, forward simulations were used to study the effects of muscles on the acceleration of COM in FW and BW. We found that a reversal in function was indeed present in the muscle control of the horizontal movement of COM (e.g., tibialis anterior and gastrocnemius). In contrast, muscles' antigravity contributions maintained their function for both directions of movement. An important outcome of the present study is therefore that similar muscles can be used to achieve opposite functional demands at the level of control of the COM when walking direction is reversed. However, some muscles showed direction-specific contributions (i.e., dorsiflexors). We concluded that the changes in muscle contributions imply that a simple time reversal would be insufficient to produce BW from FW. We therefore propose that BW utilizes extra elements, presumably supraspinal, in addition to a common spinal drive. These additions are needed for propulsion and require a partial reconfiguration of lower level common networks. PMID:22423005

  12. Gravity signatures of terrane accretion

    Science.gov (United States)

    Franco, Heather; Abbott, Dallas

    1999-01-01

    In modern collisional environments, accreted terranes are bracketed by forearc gravity lows, a gravitational feature which results from the abandonment of the original trench and the initiation of a new trench seaward of the accreted terrane. The size and shape of the gravity low depends on the type of accreted feature and the strength of the formerly subducting plate. Along the Central American trench, the accretion of Gorgona Island caused a seaward trench jump of 48 to 66 km. The relict trench axes show up as gravity lows behind the trench with minimum values of -78 mgal (N of Gorgona) and -49 mgal (S of Gorgona) respectively. These forearc gravity lows have little or no topographic expression. The active trench immediately seaward of these forearc gravity lows has minimum gravity values of -59 mgal (N of Gorgona) and -58 mgal (S of Gorgona), respectively. In the north, the active trench has a less pronounced gravity low than the sediment covered forearc. In the Mariana arc, two Cretaceous seamounts have been accreted to the Eocene arc. The northern seamount is most likely a large block, the southern seamount may be a thrust slice. These more recent accretion events have produced modest forearc topographic and gravity lows in comparison with the topographic and gravity lows within the active trench. However, the minimum values of the Mariana forearc gravity lows are modest only by comparison to the Mariana Trench (-216 mgal); their absolute values are more negative than at Gorgona Island (-145 to -146 mgal). We speculate that the forearc gravity lows and seaward trench jumps near Gorgona Island were produced by the accretion of a hotspot island from a strong plate. The Mariana gravity lows and seaward trench jumps (or thrust slices) were the result of breaking a relatively weak plate close to the seamount edifice. These gravity lows resulting from accretion events should be preserved in older accreted terranes.

  13. Gravitomagnetic Acceleration of Black Hole Accretion Disk Matter to Polar Jets

    Science.gov (United States)

    Poirier, John; Mathews, Grant

    2015-04-01

    It is shown that the motion of the neutral masses in an accretion disk orbiting a black hole creates a magnetic-like (gravitomagnetic) field that vertically accelerates neutral particles near the accretion disk away from the disk and then inward toward the axis of the accretion disk. Moreover, as the accelerated material nears the axis, a frame-dragging effect twists the trajectories around the axis thus contributing to the formation of a narrow polar jet emanating from the poles.

  14. Accretion on to Magnetic White Dwarfs

    Directory of Open Access Journals (Sweden)

    Wickramasinghe Dayal

    2014-01-01

    The polars have no counterparts in neutron star systems and their study provides unique insights into the complex nature of the magnetospheric boundary. The observed properties of accretion shocks at the white dwarf surface such as the anomalous soft-X-ray excess and its time variability provide strong support for the hypothesis that under certain circumstances the field channelled funnel flow is “blobby”. This has been attributed to interchange instabilities such as the Magnetic Rayleigh-Taylor instability in the shocked gas at the stream-magnetosphere boundary where the stream fragments into discrete clumps of gas. As the clumps penetrate into the magnetosphere, they are shredded into smaller mass blobs via the Kelvin-Helmholtz instability that then couple on to field lines over an extended inner transition region in the orbital plane. The more massive blobs penetrate deep into the photosphere of the white dwarf releasing their energy as a reprocessed soft-X-ray black body component. Although similar instabilities are expected in the inner transition region in disced accretion albeit on a different scale there has been no direct observational evidence for blobby accretion in the generally lower field and disced IPs.

  15. Neutron star accretion and the neutrino fireball

    International Nuclear Information System (INIS)

    Colgate, S.A.; Herant, M.E.; Benz, W.

    1991-01-01

    The mixing necessary to explain the ''Fe'' line widths and possibly the observed red shifts of 1987A is explained in terms of large scale, entropy conserving, up and down flows (calculated with a smooth particle 2-D code) taking place between the neutron star and the explosion shock wave due to the gravity and neutrino deposition. Depending upon conditions of entropy and mass flux further accretion takes place in single events, similar to relaxation oscillator, fed by the downward flows of low entropy matter. The shock, in turn, is driven by the upflow of the buoyant high entropy bubbles. Some accretion events will reach a temperature high enough to create a neutrino ''fireball,'' a region hot enough, 11 Mev, so as to be partially opaque to its own (neutrino) radiation. The continuing neutrino deposition drives the explosion shock until the entropy of matter flowing downwards onto the neutron star is high enough to prevent further accretion. This process should result in a robust supernova explosion

  16. Hyper-Eddington accretion in GRB

    International Nuclear Information System (INIS)

    Janiuk, A.; Czerny, B.; Perna, R.; Di Matteo, T.

    2005-01-01

    Popular models of the GRB origin associate this event with a cosmic explosion, birth of a stellar mass black ho le and jet ejection. Due to the shock collisions that happen in the jet, the gamma rays are produced and we detect a burst of duration up to several tens of seconds. This burst duration is determined by the lifetime of the central engine, which may be different in various scenarios. Characteristically, the observed bursts have a bimodal distribution and constitute the two classes: short (t < 2 s) and long bursts. Theoretical models invoke the mergers of two neutron stars or a neutron star with a black hole, or, on the other hand, a massive star explosion (collapsar). In any of these models we have a phase of disc accretion onto a newly born black hole: the di se is formed from the disrupted neutron star or fed by the material fallback from the ejected collapsar envelope. The disc is extremely hot and dense, and the accretion rate is orders of magnitude higher than the Eddington rate. In such physical conditions the main cooling mechanism is neutrino emission, and one of possible ways of energy extraction from the accretion disc is the neutrino-antineutrino annihilation

  17. The Association between Total Protein and Vegetable Protein Intake and Low Muscle Mass among the Community-Dwelling Elderly Population in Northern Taiwan

    Directory of Open Access Journals (Sweden)

    Ru-Yi Huang

    2016-06-01

    Full Text Available Sarcopenia, highly linked with fall, frailty, and disease burden, is an emerging problem in aging society. Higher protein intake has been suggested to maintain nitrogen balance. Our objective was to investigate whether pre-sarcopenia status was associated with lower protein intake. A total of 327 community-dwelling elderly people were recruited for a cross-sectional study. We adopted the multivariate nutrient density model to identify associations between low muscle mass and dietary protein intake. The general linear regression models were applied to estimate skeletal muscle mass index across the quartiles of total protein and vegetable protein density. Participants with diets in the lowest quartile of total protein density (<13.2% were at a higher risk for low muscle mass (odds ratio (OR 3.03, 95% confidence interval (CI 1.37–6.72 than those with diets in the highest quartile (≥17.2%. Similarly, participants with diets in the lowest quartile of vegetable protein density (<5.8% were at a higher risk for low muscle mass (OR 2.34, 95% CI 1.14–4.83 than those with diets in the highest quartile (≥9.4%. Furthermore, the estimated skeletal muscle mass index increased significantly across the quartiles of total protein density (p = 0.023 and vegetable protein density (p = 0.025. Increasing daily intakes of total protein and vegetable protein densities appears to confer protection against pre-sarcopenia status.

  18. Assessment of the influence of body composition on bone mass in children and adolescents based on a functional analysis of the muscle-bone relationship.

    Science.gov (United States)

    Golec, Joanna; Chlebna-Sokół, Danuta

    2014-01-01

    The functional model of skeletal development considers the mechanical factor to be the most important skeletal modulant. The aim of the study was a functional analysis of the bone-muscle relationship in children with low and normal bone mass. The study involved 149 children with low and 99 children with normal bone mass (control group). All patients underwent a densitometry examination (DXA). Low bone mass was diagnosed if the Z-score was below values of Z-scores for all parameters in children with low bone mass as compared to the control group. Children with low bone mass had lower content of adipose and muscle tissue and a marked deficit of muscle tissue with regard to height (which according to mechanostat theory leads to lower muscle-generated strain on bones). This group of children had also lower TBBMC/LBM Z-scores, which indicates greater fracture susceptibility. 1. Functional analysis, which showed associations between bone and muscle tissues, can be useful for diagnosing and monitoring skeletal system disorders as well as making therapeutic decisions.2. The study emphasizes the role of proper nutrition and physical activities, which contribute to proper body composition, in the prevention of bone mineralization disorders in childhood and adolescence. 3. The study showed the inadequacy of the classic reference ranges used in interpreting DXA data in children and demonstrated the usefulness of continuous variables for that purpose.

  19. Increased Muscular 5α-Dihydrotestosterone in Response to Resistance Training Relates to Skeletal Muscle Mass and Glucose Metabolism in Type 2 Diabetic Rats.

    Directory of Open Access Journals (Sweden)

    Naoki Horii

    Full Text Available Regular resistance exercise induces skeletal muscle hypertrophy and improvement of glycemic control in type 2 diabetes patients. Administration of dehydroepiandrosterone (DHEA, a sex steroid hormone precursor, increases 5α-dihydrotestosterone (DHT synthesis and is associated with improvements in fasting blood glucose level and skeletal muscle hypertrophy. Therefore, the aim of this study was to investigate whether increase in muscle DHT levels, induced by chronic resistance exercise, can contribute to skeletal muscle hypertrophy and concomitant improvement of muscular glucose metabolism in type 2 diabetic rats. Male 20-week-old type 2 diabetic rats (OLETF were randomly divided into 3 groups: sedentary control, resistance training (3 times a week on alternate days for 8 weeks, or resistance training with continuous infusion of a 5α-reductase inhibitor (n = 8 each group. Age-matched, healthy nondiabetic Long-Evans Tokushima Otsuka (LETO rats (n = 8 were used as controls. The results indicated that OLETF rats showed significant decrease in muscular DHEA, free testosterone, DHT levels, and protein expression of steroidogenic enzymes, with loss of skeletal muscle mass and hyperglycemia, compared to that of LETO rats. However, 8-week resistance training in OLETF rats significantly increased the levels of muscle sex steroid hormones and protein expression of steroidogenic enzymes with a concomitant increase in skeletal muscle mass, improved fasting glucose level, and insulin sensitivity index. Moreover, resistance training accelerated glucose transporter-4 (GLUT-4 translocation and protein kinase B and C-ζ/λ phosphorylation. Administering the 5α-reductase inhibitor in resistance-trained OLETF rats resulted in suppression of the exercise-induced effects on skeletal muscle mass, fasting glucose level, insulin sensitivity index, and GLUT-4 signaling, with a decline in muscular DHT levels. These findings suggest that resistance training

  20. LUNAR ACCRETION FROM A ROCHE-INTERIOR FLUID DISK

    Energy Technology Data Exchange (ETDEWEB)

    Salmon, Julien; Canup, Robin M., E-mail: julien@boulder.swri.edu, E-mail: robin@boulder.swri.edu [Department of Space Studies, Southwest Research Institute, 1050 Walnut Street, Suite 300, Boulder, CO 80302 (United States)

    2012-11-20

    We use a hybrid numerical approach to simulate the formation of the Moon from an impact-generated disk, consisting of a fluid model for the disk inside the Roche limit and an N-body code to describe accretion outside the Roche limit. As the inner disk spreads due to a thermally regulated viscosity, material is delivered across the Roche limit and accretes into moonlets that are added to the N-body simulation. Contrary to an accretion timescale of a few months obtained with prior pure N-body codes, here the final stage of the Moon's growth is controlled by the slow spreading of the inner disk, resulting in a total lunar accretion timescale of {approx}10{sup 2} years. It has been proposed that the inner disk may compositionally equilibrate with the Earth through diffusive mixing, which offers a potential explanation for the identical oxygen isotope compositions of the Earth and Moon. However, the mass fraction of the final Moon that is derived from the inner disk is limited by resonant torques between the disk and exterior growing moons. For initial disks containing <2.5 lunar masses (M{sub Last-Quarter-Moon }), we find that a final Moon with mass > 0.8 M{sub Last-Quarter-Moon} contains {<=}60% material derived from the inner disk, with this material preferentially delivered to the Moon at the end of its accretion.

  1. FILAMENTARY ACCRETION FLOWS IN THE EMBEDDED SERPENS SOUTH PROTOCLUSTER

    International Nuclear Information System (INIS)

    Kirk, Helen; Myers, Philip C.; Bourke, Tyler L.; Gutermuth, Robert A.; Wilson, Grant W.; Hedden, Abigail

    2013-01-01

    One puzzle in understanding how stars form in clusters is the source of mass—is all of the mass in place before the first stars are born, or is there an extended period when the cluster accretes material which can continuously fuel the star formation process? We use a multi-line spectral survey of the southern filament associated with the Serpens South embedded cluster-forming region in order to determine if mass is accreting from the filament onto the cluster, and whether the accretion rate is significant. Our analysis suggests that material is flowing along the filament's long axis at a rate of ∼30 M ☉ Myr –1 (inferred from the N 2 H + velocity gradient along the filament), and radially contracting onto the filament at ∼130 M ☉ Myr –1 (inferred from HNC self-absorption). These accretion rates are sufficient to supply mass to the central cluster at a similar rate to the current star formation rate in the cluster. Filamentary accretion flows may therefore be very important in the ongoing evolution of this cluster.

  2. Three-dimensional hydrodynamical models of wind and outburst-related accretion in symbiotic systems

    Science.gov (United States)

    de Val-Borro, M.; Karovska, M.; Sasselov, D. D.; Stone, J. M.

    2017-07-01

    Gravitationally focused wind accretion in binary systems consisting of an evolved star with a gaseous envelope and a compact accreting companion is a possible mechanism to explain mass transfer in symbiotic binaries. We study the mass accretion around the secondary caused by the strong wind from the primary late-type component using global three-dimensional hydrodynamic numerical simulations during quiescence and outburst stages. In particular, the dependence of the mass accretion rate on the mass-loss rate, wind parameters and phases of wind outburst development is considered. For a typical wind from an asymptotic giant branch star with a mass-loss rate of 10-6 M⊙ yr-1 and wind speeds of 20-50 km s-1, the mass transfer through a focused wind results in efficient infall on to the secondary. Accretion rates on to the secondary of 5-20 per cent of the mass-loss from the primary are obtained during quiescence and outburst periods where the wind velocity and mass-loss rates are varied, about 20-50 per cent larger than in the standard Bondi-Hoyle-Lyttleton approximation. This mechanism could be an important method for explaining observed accretion luminosities and periodic modulations in the accretion rates for a broad range of interacting binary systems.

  3. Reaction rate and composition dependence of the stability of thermonuclear burning on accreting neutron stars

    International Nuclear Information System (INIS)

    Keek, L.; Cyburt, R. H.; Heger, A.

    2014-01-01

    The stability of thermonuclear burning of hydrogen and helium accreted onto neutron stars is strongly dependent on the mass accretion rate. The burning behavior is observed to change from Type I X-ray bursts to stable burning, with oscillatory burning occurring at the transition. Simulations predict the transition at a 10 times higher mass accretion rate than observed. Using numerical models we investigate how the transition depends on the hydrogen, helium, and CNO mass fractions of the accreted material, as well as on the nuclear reaction rates of 3α and the hot-CNO breakout reactions 15 O(α, γ) 19 Ne and 18 Ne(α, p) 21 Na. For a lower hydrogen content the transition is at higher accretion rates. Furthermore, most experimentally allowed reaction rate variations change the transition accretion rate by at most 10%. A factor 10 decrease of the 15 O(α, γ) 19 Ne rate, however, produces an increase of the transition accretion rate of 35%. None of our models reproduce the transition at the observed rate, and depending on the true 15 O(α, γ) 19 Ne reaction rate, the actual discrepancy may be substantially larger. We find that the width of the interval of accretion rates with marginally stable burning depends strongly on both composition and reaction rates. Furthermore, close to the stability transition, our models predict that X-ray bursts have extended tails where freshly accreted fuel prolongs nuclear burning.

  4. Influence of combined resistance training and healthy diet on muscle mass in healthy elderly women: a randomized controlled trial.

    Science.gov (United States)

    Strandberg, Emelie; Edholm, Peter; Ponsot, Elodie; Wåhlin-Larsson, Britta; Hellmén, Erik; Nilsson, Andreas; Engfeldt, Peter; Cederholm, Tommy; Risérus, Ulf; Kadi, Fawzi

    2015-10-15

    The delivery of efficient nonpharmacological treatment to prevent the loss of muscle mass in older adults is a major challenge, and information on the combined effects of training and diet is particularly important. Here we aimed to evaluate the effects of 24 wk of resistance training combined with a healthy dietary approach (n-6/n-3 ratio healthy and physically active older women (65-70 years). The three-armed randomized controlled trial included a resistance training + healthy diet group (RT-HD), a resistance training group (RT), and controls (CON). All subjects included in the study were physically active and had low levels of serum inflammatory markers. In accordance with the dietary goals, the n-6/n-3 ratio dietary intake significantly decreased only in RT-HD by 42%. An increase in 1 repetition maximum in leg extension occurred in RT (+20.4%) and RT-HD (+20.8%), but not in CON. Interestingly, leg lean mass significantly increased only in RT-HD (+1.8%). While there were no changes in serum C-reactive protein and IL-6 levels, a significant decrease in serum level of the pro-inflammatory precursor arachidonic acid (-5.3 ± 9.4%) together with an increase in serum n-3 docosahexaenoic acid (+8.3%) occurred only in RT-HD. Altogether, this study demonstrates that the effects of resistance training on muscle mass in healthy older adults can be optimized by the adoption of a healthy diet. Copyright © 2015 the American Physiological Society.

  5. Wind accretion and formation of disk structures in symbiotic binary systems

    Science.gov (United States)

    de Val-Borro, M.; Karovska, M.; Sasselov, D. D.; Stone, J. M.

    2015-05-01

    We investigate gravitationally focused wind accretion in binary systems consisting of an evolved star with a gaseous envelope and a compact accreting companion. We study the mass accretion and formation of an accretion disk around the secondary caused by the strong wind from the primary late-type component using global 2D and 3D hydrodynamic numerical simulations. In particular, the dependence of the mass accretion rate on the mass loss rate, wind temperature and orbital parameters of the system is considered. For a typical slow and massive wind from an evolved star the mass transfer through a focused wind results in rapid infall onto the secondary. A stream flow is created between the stars with accretion rates of a 2--10% percent of the mass loss from the primary. This mechanism could be an important method for explaining periodic modulations in the accretion rates for a broad range of interacting binary systems and fueling of a large population of X-ray binary systems. We test the plausibility of these accretion flows indicated by the simulations by comparing with observations of the symbiotic variable system CH Cyg.

  6. Strong Relation between Muscle Mass Determined by D3-creatine Dilution, Physical Performance and Incidence of Falls and Mobility Limitations in a Prospective Cohort of Older Men.

    Science.gov (United States)

    Cawthon, Peggy M; Orwoll, Eric S; Peters, Katherine E; Ensrud, Kristine E; Cauley, Jane A; Kado, Deborah M; Stefanick, Marcia L; Shikany, James M; Strotmeyer, Elsa S; Glynn, Nancy W; Caserotti, Paolo; Shankaran, Mahalakshmi; Hellerstein, Marc; Cummings, Steven R; Evans, William J

    2018-06-12

    Direct assessment of skeletal muscle mass in older adults is clinically challenging. Relationships between lean mass and late-life outcomes have been inconsistent. The D3-creatine dilution method provides a direct assessment of muscle mass. Muscle mass was assessed by D3-creatine (D3Cr) dilution in 1,382 men (mean age, 84.2 yrs). Participants completed the Short Physical Performance Battery (SPPB); usual walking speed (6 meters); and DXA lean mass. Men self-reported mobility limitations (difficulty walking 2-3 blocks or climbing 10 steps); recurrent falls (2+); and serious injurious falls in the subsequent year. Across quartiles of D3Cr muscle mass/body mass, multivariate linear models calculated means for SPPB and gait speed; multivariate logistic models calculated odds ratios for incident mobility limitations or falls. Compared to men in the highest quartile, those in the lowest quartile of D3Cr muscle mass/body mass had slower gait speed (Q1: 1.04 vs Q4: 1.17 m/s); lower SPPB (Q1: 8.4 vs Q4: 10.4 points); greater likelihood of incident serious injurious falls (OR Q1 vs Q4: 2.49, 95% CI: 1.37, 4.54); prevalent mobility limitation (OR Q1 vs Q4,: 6.1, 95%CI: 3.7, 10.3) and incident mobility limitation (OR Q1 vs Q4: 2.15 95% CI: 1.42, 3.26); p for trend strongly related to physical performance, mobility and incident injurious falls in older me.

  7. Age-associated declines in muscle mass, strength, power, and physical performance: impact on fear of falling and quality of life.

    Science.gov (United States)

    Trombetti, A; Reid, K F; Hars, M; Herrmann, F R; Pasha, E; Phillips, E M; Fielding, R A

    2016-02-01

    This 3-year longitudinal study among older adults showed that declining muscle mass, strength, power, and physical performance are independent contributing factors to increased fear of falling, while declines of muscle mass and physical performance contribute to deterioration of quality of life. Our findings reinforce the importance of preserving muscle health with advancing age. The age-associated loss of skeletal muscle quantity and function are critical determinants of independent physical functioning in later life. Longitudinal studies investigating how decrements in muscle components of sarcopenia impact fear of falling (FoF) and quality of life (QoL) in older adults are lacking. Twenty-six healthy older subjects (age, 74.1 ± 3.7; Short Physical Performance Battery (SPPB) score ≥10) and 22 mobility-limited older subjects (age, 77.2 ± 4.4; SPPB score ≤9) underwent evaluations of lower extremity muscle size and composition by computed tomography, strength and power, and physical performance at baseline and after 3-year follow-up. The Falls Efficacy Scale (FES) and Short Form-36 questionnaire (SF-36) were also administered at both timepoints to assess FoF and QoL, respectively. At 3-year follow-up, muscle cross-sectional area (CSA) (p < 0.013) and power decreased (p < 0.001), while intermuscular fat infiltration increased (p < 0.001). These decrements were accompanied with a longer time to complete 400 m by 22 ± 46 s (p < 0.002). Using linear mixed-effects regression models, declines of muscle CSA, strength and power, and SPPB score were associated with increased FES score (p < 0.05 for each model). Reduced physical component summary score of SF-36 over follow-up was independently associated with decreased SPPB score (p < 0.020), muscle CSA (p < 0.046), and increased 400 m walk time (p < 0.003). In older adults with and without mobility limitations, declining muscle mass, strength, power, and physical

  8. TEMPERATURE STRUCTURE OF PROTOPLANETARY DISKS UNDERGOING LAYERED ACCRETION

    International Nuclear Information System (INIS)

    Lesniak, M. V.; Desch, S. J.

    2011-01-01

    We calculate the temperature structures of protoplanetary disks (PPDs) around T Tauri stars heated by both incident starlight and viscous dissipation. We present a new algorithm for calculating the temperatures in disks in hydrostatic and radiative equilibrium, based on Rybicki's method for iteratively calculating the vertical temperature structure within an annulus. At each iteration, the method solves for the temperature at all locations simultaneously, and converges rapidly even at high (>>10 4 ) optical depth. The method retains the full frequency dependence of the radiation field. We use this algorithm to study for the first time disks evolving via the magnetorotational instability. Because PPD midplanes are weakly ionized, this instability operates preferentially in their surface layers, and disks will undergo layered accretion. We find that the midplane temperatures T mid are strongly affected by the column density Σ a of the active layers, even for fixed mass accretion rate M-dot . Models assuming uniform accretion predict midplane temperatures in the terrestrial planet forming region several x 10 2 K higher than our layered accretion models do. For M-dot -7 M sun yr -1 and the column densities Σ a -2 associated with layered accretion, disk temperatures are indistinguishable from those of a passively heated disk. We find emergent spectra are insensitive to Σ a , making it difficult to observationally identify disks undergoing layered versus uniform accretion.

  9. SURPRISINGLY WEAK MAGNETISM ON YOUNG ACCRETING BROWN DWARFS

    International Nuclear Information System (INIS)

    Reiners, A.; Basri, G.; Christensen, U. R.

    2009-01-01

    We have measured the surface magnetic flux on four accreting young brown dwarfs and one nonaccreting young very low mass (VLM) star utilizing high-resolution spectra of absorption lines of the FeH molecule. A magnetic field of 1-2 kG had been proposed for one of the brown dwarfs, Two Micron All Sky Survey (2MASS) J1207334-393254, because of its similarities to higher mass T Tauri stars as manifested in accretion and the presence of a jet. We do not find clear evidence for a kilogauss field in any of our young brown dwarfs but do find a 2 kG field on the young VLM star. Our 3σ upper limit for the magnetic flux in 2MASS J1207334-393254 just reaches 1 kG. We estimate the magnetic field required for accretion in young brown dwarfs given the observed rotations, and find that fields of only a few hundred gauss are sufficient for magnetospheric accretion. This predicted value is less than our observed upper limit. We conclude that magnetic fields in young brown dwarfs are a factor of 5 or more lower than in young stars of about one solar mass, and in older stars with spectral types similar to our young brown dwarfs. It is interesting that, during the first few million years, the fields scale down with mass in line with what is needed for magnetospheric accretion, yet no such scaling is observed at later ages within the same effective temperature range. This scaling is opposite to the trend in rotation, with shorter rotation periods for very young accreting brown dwarfs compared with accreting solar-mass objects (and very low Rossby numbers in all cases). We speculate that in young objects a deeper intrinsic connection may exist between magnetospheric accretion and magnetic field strength, or that magnetic field generation in brown dwarfs may be less efficient than in stars. Neither of these currently has an easy physical explanation.

  10. Changes in muscle size and MHC composition in response to resistance exercise with heavy and light loading intensity

    DEFF Research Database (Denmark)

    Holm, L.; Reitelseder, S.; Pedersen, T.G.

    2008-01-01

    resonance imaging, muscle biopsies were obtained bilaterally from vastus lateralis for determination of myosin heavy chain (MHC) composition, and maximal muscle strength was assessed by 1RM testing and in an isokinetic dynamometer at 60 degrees /s. Quadriceps muscle cross-sectional area increased (P ...Muscle mass accretion is accomplished by heavy-load resistance training. The effect of light-load resistance exercise has been far more sparsely investigated with regard to potential effect on muscle size and contractile strength. We applied a resistance exercise protocol in which the same...... individual trained one leg at 70% of one-repetition maximum (1RM) (heavy load, HL) while training the other leg at 15.5% 1RM (light load, LL). Eleven sedentary men (age 25 +/- 1 yr) trained for 12 wk at three times/week. Before and after the intervention muscle hypertrophy was determined by magnetic...

  11. Transitional millisecond pulsars in the low-level accretion state

    Science.gov (United States)

    Jaodard, Amruta D.; Hessels, Jason W. T.; Archibald, Anne; Bogdanov, Slavko; Deller, Adam; Hernandez Santisteban, Juan; Patruno, Alessandro; D'Angelo, Caroline; Bassa, Cees; Amruta Jaodand

    2018-01-01

    In the canonical pulsar recycling scenario, a slowly spinning neutron star can be rejuvenated to rapid spin rates by the transfer of angular momentum and mass from a binary companion star. Over the last decade, the discovery of three transitional millisecond pulsars (tMSPs) has allowed us to study recycling in detail. These systems transition between accretion-powered (X-ray) and rotation-powered (radio) pulsar states within just a few days, raising questions such as: what triggers the state transition, when does the recycling process truly end, and what will the radio pulsar’s final spin rate be? Systematic multi-wavelength campaigns over the last decade have provided critical insights: multi-year-long, low-level accretion states showing coherent X-ray pulsations; extremely stable, bi-modal X-ray light curves; outflows probed by radio continuum emission; a surprising gamma-ray brightening during accretion, etc. In my thesis I am trying to bring these clues together to understand the low-level accretion process that recycles a pulsar. For example, recently we timed PSR J1023+0038 in the accretion state and found it to be spinning down ~26% faster compared to the non-accreting radio pulsar state. We are currently conducting simultaneous multi-wavelength campaigns (XMM, HST, Kepler and VLA) to understand the global variability of the accretion flow, as well as high-energy Fermi-LAT observations to probe the gamma-ray emission mechanism. I will highlight these recent developments, while also presenting a broad overview of tMSPs as exciting new laboratories to test low-level accretion onto magnetized neutron stars.

  12. The obesity paradox in men with coronary heart disease and heart failure: the role of muscle mass and leptin.

    Science.gov (United States)

    Wannamethee, S Goya; Shaper, A Gerald; Whincup, Peter H; Lennon, Lucy; Papacosta, Olia; Sattar, Naveed

    2014-01-15

    We have investigated the role of muscle mass, natriuretic peptides and adipokines in explaining the obesity paradox. The obesity paradox relates to the association between obesity and increased survival in patients with coronary heart disease (CHD) or heart failure (HF). Prospective study of 4046 men aged 60-79 years followed up for a mean period of 11 years, during which 1340 deaths occurred. The men were divided according to the presence of doctor diagnosed CHD and HF: (i) no CHD or HF ii), with CHD (no HF) and (iii) with HF. Overweight (BMI 25-9.9 kg/m(2)) and obesity (BMI ≥ 30 kg/m(2)) were associated with lower mortality risk compared to men with normal weight (BMI 18.5-24.9 kg/m(2)) in those with CHD [hazards ratio (HR) 0.71 (0.56,0.91) and 0.77 (0.57,1.04); p=0.04 for trend] and in those with HF [HR 0.57 (0.28,1.16) and 0.41 (0.16,1.09; p=0.04 for trend). Adjustment for muscle mass and NT-proBNP attenuated the inverse association in those with CHD (no HF) [HR 0.78 (0.61,1.01) and 0.96 (0.68,1.36) p=0.60 for trend) but made minor differences to those with HF [p=0.05]. Leptin related positively to mortality in men without HF but inversely to mortality in those with HF; adjustment for leptin abolished the BMI mortality association in men with HF [HR 0.82 (0.31,2.20) and 0.99 (0.27,3.71); p=0.98 for trend]. The lower mortality risk associated with excess weight in men with CHD without HF may be due to higher muscle mass. In men with HF, leptin (possibly reflecting cachexia) explain the inverse association. Copyright © 2013. Published by Elsevier Ireland Ltd.

  13. Comparison between body mass index, triceps skin fold thickness and mid-arm muscle circumference in Saudi adolescents

    International Nuclear Information System (INIS)

    Abdalkhail, B.; Shawky, S.

    2002-01-01

    Adolescence is an important period in an individual's life. Overweight and obesity are fraught with several health problems even late in life. The objective of this study was estimate the overweight, obesity, body fat and muscle content of Saudi adolescents as compared to a recognized reference population. Data were collected from a sample of Saudi adolescents in Jeddah from 42 boys' and 42 girls' school during the month of April 2000. Data collection was done by personal interviews to collect sociodemograhic factors and by direct measurement of weight, height, triceps skin fold thickness (TSF) and mid-arm circumference (MAC). The 50th, 85th and 95th percentiles(P50, P85 and P95) for body mass index (BMI) and triceps skin fold thickness (TSF) were taken, then the 50th, 90th, and 95th percentiles (P50, P90 and P95) for the mid-arm muscle circumference (MAMC) were calculated. These measurements were compared with corresponding values of the National Health and Nutrition Examination Survey I (NHANES I). The P85 and P95 for the BMI and TSF were higher for Saudi adolescents than the NHANES I and the difference was wider for P95. Conversely, there was a lower MAMC at P90 and P95thane the NHANES I reference population curves. The lower MAMC curves were less marked in girls than in boys. On the other hand Saudi boys and girls showed on average similar body mass index indicated by MBI at P50, which was misleading, since those adolescents showing similar body mass index had more fatness than of average reference population indicated by TSF and P50, and less muscularity on average than reference population indicated MAMC at P-50. Overweight and obesity with increased body fat content and decreased body muscle content appear to be widespread among Saudi adolescents even among those adolescents showing average body index. Public health interventions are required to improve quality of food, encourage physical, activity and exercise, as well as correct the perception of

  14. Evidence of Accretion in Saturn's F Ring (Invited)

    Science.gov (United States)

    Agnor, C. B.; Buerle, K.; Murray, C. D.; Evans, M. W.; Cooper, N. J.; Williams, G. W.

    2010-12-01

    Lying slightly outside the classical Roche radius and being strongly perturbed by the adjacent moons Prometheus and Pandora, Saturn's F ring represents a unique astrophysical laboratory for examining the processes of mass accretion and moonlet formation. Recent images from the Cassini spacecraft reveal optically thick clumps, capable of casting shadows, and associated structures in regions of the F ring following close passage by Prometheus. Here we examine the accretion environment of the F ring and Prometheus' role in moonlet formation and evolution. Using the observed structures adjacent to these clumps and dynamical arguments we estimate the masses of these clumps and find them comparable to that of ~10-20-km contiguous moonlets. Further, we show that Prometheus' perturbations on the F ring create regions of enhanced density and low relative velocity that may accelerate the accretion of clumps and moonlets.

  15. Influence of Nordic Walking Training on Muscle Strength and the Electromyographic Activity of the Lower Body in Women With Low Bone Mass

    Directory of Open Access Journals (Sweden)

    Ossowski Zbigniew

    2016-06-01

    Full Text Available Introduction. Osteoporosis and osteopenia are related to changes in the quantity and quality of skeletal muscle and contribute to a decreased level of muscle strength. The purpose of this study was to evaluate the impact of Nordic walking training on muscle strength and the electromyographic (EMG activity of the lower body in women with low bone mass. Material and methods. The participants of the study were 27 women with low bone mass. The sample was randomly divided into two groups: a control group and an experimental group. Women from the experimental group participated in 12 weeks of regular Nordic walking training. Functional strength was assessed with a 30-second chair stand test. The EMG activities of the gluteus maximus (GMax, rectus femoris (RF, biceps femoris (BF, soleus (SOL, and lumbar (LB muscles were measured using a surface electromyogram. Results. Nordic walking training induced a significant increase in the functional strength (p = 0.006 of the lower body and activity of GMax (p = 0.013 and a decrease in body mass (p = 0.006 in women with reduced bone mass. There was no statistically significant increase in the EMG activities of the RF, BF, SOL, or LB muscles. The study did not indicate any significant changes in functional muscle strength, the EMG activity of the lower body, or anthropometry in women from the control group. Conclusions. Nordic walking training induces positive changes in lower body strength and the electromyographic activity of the gluteus maximus as well as a decrease in body mass in women with low bone mass.

  16. Ratio of dietary ω-3 and ω-6 fatty acids-independent determinants of muscle mass-in hemodialysis patients with diabetes.

    Science.gov (United States)

    Wong, Te-Chih; Chen, Yu-Tong; Wu, Pei-Yu; Chen, Tzen-Wen; Chen, Hsi-Hsien; Chen, Tso-Hsiao; Hsu, Yung-Ho; Yang, Shwu-Huey

    2016-09-01

    ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) are essential nutrients in the human diet and possibly affect muscle mass. We evaluated the association between the dietary ratios of ω-3 and ω-6 PUFAs and muscle mass, indicated as skeletal muscle mass (SMM) and appendicular skeletal muscle mass (ASM), in patients with diabetes undergoing hemodialysis (HD). In this cross-sectional study, data on 69 patients with diabetes who underwent standard HD therapy were analyzed. For estimating muscle mass, anthropometric and bioelectrical impedance analyses were conducted following dialysis. In addition, routine laboratory and 3-d dietary data were obtained. The adequate intake (AI) cut-off for ω-3 PUFAs was 1.6 g/d and 1.1 g/d for male and female patients, respectively. The average age of the participants was 63.0 ± 10.4 y. The mean ratios of ω-3/ω-6 PUFA intake, ω-6/ω-3 PUFA intake, SMM, and ASM of the patients were 0.13 ± 0.07, 9.4 ± 6.4, 24.6 ± 5.4 kg, and 18.3 ± 4.6 kg, respectively. Patients who had AI of ω-3 PUFAs had significantly higher SMM and ASM than did their counterparts. Linear and stepwise multivariable adjustment analyses revealed that insulin resistance and the ω-6/ω-3 PUFA ratio were the independent deleterious determinants of ASM normalized to height in HD patients. Patients with AI of ω-3 PUFAs had total-body SMM and ASM that were more appropriate. A higher dietary ratio of ω-6/ω-3 PUFAs was associated with reduced muscle mass in HD patients. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Gravitomagnetic acceleration of accretion disk matter to polar jets

    Science.gov (United States)

    Poirier, John; Mathews, Grant

    2016-03-01

    The motion of the masses of an accretion disk around a black hole creates a general relativistic, gravitomagnetic field (GEM) from the moving matter (be it charged or uncharged) of the accretion disk. This GEM field accelerates moving masses (neutral or charged) near the accretion disk vertically upward and away from the disk, and then inward toward the axis of the disk. As the accelerated material nears the axis with approximately vertical angles, a frame dragging effect contributes to the formation of narrow jets emanating from the poles. This GEM effect is numerically evaluated in the first post Newtonian (1PN) approximation from observable quantities like the mass and velocity of the disk. This GEM force is linear in the total mass of the accretion disk matter and quadratic in the velocity of matter near to the disk with approximately the same velocity. Since these masses and velocities can be quite high in astrophysical contexts, the GEM force, which in other contexts is weak, is quite significant. This GEM effect is compared to the ordinary electromagnetic effects applied to this problem in the past.

  18. On accretion from an inhomogeneous medium

    International Nuclear Information System (INIS)

    Davies, R.E.; Pringle, J.E.

    1980-01-01

    Hypersonic accretion flow in two dimensions from an infinite medium which contains a small density and/or velocity gradient is considered. To first order in rsub(a)/h, where rsub(a) is the accretion radius and h the scale of the gradient, the accretion rate is unaffected and the accreted angular momentum is zero. Thus previous estimates of the amount of angular momentum accreted may severely overestimate the actual value. (author)

  19. How cores grow by pebble accretion. I. Direct core growth

    Science.gov (United States)

    Brouwers, M. G.; Vazan, A.; Ormel, C. W.

    2018-03-01

    Context. Planet formation by pebble accretion is an alternative to planetesimal-driven core accretion. In this scenario, planets grow by the accretion of cm- to m-sized pebbles instead of km-sized planetesimals. One of the main differences with planetesimal-driven core accretion is the increased thermal ablation experienced by pebbles. This can provide early enrichment to the planet's envelope, which influences its subsequent evolution and changes the process of core growth. Aims: We aim to predict core masses and envelope compositions of planets that form by pebble accretion and compare mass deposition of pebbles to planetesimals. Specifically, we calculate the core mass where pebbles completely evaporate and are absorbed before reaching the core, which signifies the end of direct core growth. Methods: We model the early growth of a protoplanet by calculating the structure of its envelope, taking into account the fate of impacting pebbles or planetesimals. The region where high-Z material can exist in vapor form is determined by the temperature-dependent vapor pressure. We include enrichment effects by locally modifying the mean molecular weight of the envelope. Results: In the pebble case, three phases of core growth can be identified. In the first phase (Mcore mixes outwards, slowing core growth. In the third phase (Mcore > 0.5M⊕), the high-Z inner region expands outwards, absorbing an increasing fraction of the ablated material as vapor. Rainout ends before the core mass reaches 0.6 M⊕, terminating direct core growth. In the case of icy H2O pebbles, this happens before 0.1 M⊕. Conclusions: Our results indicate that pebble accretion can directly form rocky cores up to only 0.6 M⊕, and is unable to form similarly sized icy cores. Subsequent core growth can proceed indirectly when the planet cools, provided it is able to retain its high-Z material.

  20. Universal subhalo accretion in cold and warm dark matter cosmologies

    Science.gov (United States)

    Kubik, Bogna; Libeskind, Noam I.; Knebe, Alexander; Courtois, Hélène; Yepes, Gustavo; Gottlöber, Stefan; Hoffman, Yehuda

    2017-12-01

    The influence of the large-scale structure on host haloes may be studied by examining the angular infall pattern of subhaloes. In particular, since warm dark matter (WDM) and cold dark matter (CDM) cosmologies predict different abundances and internal properties for haloes at the low-mass end of the mass function, it is interesting to examine if there are differences in how these low-mass haloes are accreted. The accretion events are defined as the moment a halo becomes a substructure, namely when it crosses its host's virial radius. We quantify the cosmic web at each point by the shear tensor and examine where, with respect to its eigenvectors, such accretion events occur in ΛCDM and ΛWDM (1 keV sterile neutrino) cosmological models. We find that the CDM and WDM subhaloes are preferentially accreted along the principal axis of the shear tensor corresponding to the direction of weakest collapse. The beaming strength is modulated by the host and subhalo masses and by the redshift at which the accretion event occurs. Although strongest for the most massive hosts and subhaloes at high redshift, the preferential infall is found to be always aligned with the axis of weakest collapse, thus we say that it has universal nature. We compare the strength of beaming in the ΛWDM cosmology with the one found in the ΛCDM scenario. While the main findings remain the same, the accretion in the ΛWDM model for the most massive host haloes appears more beamed than in ΛCDM cosmology across all the redshifts.

  1. An ultraluminous X-ray source powered by an accreting neutron star

    DEFF Research Database (Denmark)

    Bachetti, M.; Harrison, F. A.; Walton, D. J.

    2014-01-01

    the Eddington limit for a 1.4-solar-mass object, or more than ten times brighter than any known accreting pulsar. This implies that neutron stars may not be rare in the ultraluminous X-ray population, and it challenges physical models for the accretion of matter onto magnetized compact objects....

  2. Accreting neutron stars by QFT

    Science.gov (United States)

    Chen, Shao-Guang

    layer with thickness of 1 km then q = 1 (N1S1), the gravity from N1S1 inside and exterior will be completely shielded. Because of net nuν _{0} flux is the medium to produce and transmit gravity, q obstructed by the shielding layer lie on the density of layer matter and the section of single nucleon to electronic neutrino obtained by nuclear physics experiments is about 1.1*10 ({-) 43} cm (2) . The mass inside N1S1 for exterior has not gravity interaction, it equivalent to has not inertia as the mass vanish. The neutron star is as a empty shell thereby may rapidly rotating and has not upper limit of mass and radii by the gravity accretion of N1S1, which will influence the mechanisms of pulsars, quasars and X-rays generated. At N1S1 interior the mass for exterior has not gravity which is just we searching dark matter. The mass each part will each other shielding and gravity decrease to less than the pressure of the degenerate neutron gas. The neutron star cannot collapse into a singular point with infinite density, i.e., the black hole with infinite gravity cannot be formed or the neutron star is jest the black hole in observational meaning. By the gravity accrete of N1S1 the neutron star may enlarge its shell radii but thickness keep. Only a shell gravity may be not less than any a observed value which to be deemed as black hole. The neutron star has powerful gravity certainly accompany with great surface negative charge and it may rapidly to rotate, so that there is a powerful magnetic field surround it. The accreting neutron star is as a slowly expand empty shell with fixed thickness of 1 km, its spin period depend on its radii or total accretion mass.

  3. Pre- and post-operative evaluation of ventricular function, muscle mass and valve morphology by MR tomography in Ebstein's anomaly

    International Nuclear Information System (INIS)

    Gutberlet, M.; Oellinger, H.; Amthauer, H.; Hoffmann, T.; Felix, R.