Lithomorphological aspects of northern Muria region for location candidate of the NPP radioactive wastes repository

International Nuclear Information System (INIS)

Sucipta

1995-01-01

As a part of planning and construction of NPP in the northern Muria region, a location candidate of the NPP radioactive waste repository needs to be prepared. The objective of this studywas to investigate the suitability of the geomorphologic condition of the northern Muria region for the location. The geomorphologic elements were evaluated based on the geomorphologic criteria specified by the IAEA. This study was conducted through descriptive and scoring methods for the geomorphologic elements, especially the landform and the geomorphologic processes. Based on the results of the study, the study area could be classified into three classes of suitability for the location. These are three geomorphologic units of high suitability, three units of moderate suitability and four units of low suitability. By considering the total value of the geomorphologic condition suitability and the inhibiting factors of geomorphology, three high suitability units were selected, particularly in the region of Lemahabang and Genggrengan. (author). 6 refs, 7 figs

PxAPN5 serves as a functional receptor of Cry2Ab in Plutella xylostella (L.) and its binding domain analysis.

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Pan, Zhi-Zhen; Xu, Lian; Liu, Bo; Zhang, Jing; Chen, Zheng; Chen, Qing-Xi; Zhu, Yu-Jing

2017-12-01

Lepidopteran midgut aminopeptidases N (APNs) are widely studied for their potential roles as one of the receptors for Bacillus thuringiensis (Bt) crystal toxins. In the present study, a loss of function analyses by RNAi (RNA interference) silencing of the Plutella xylostella APN5 (PxAPN5), a binding protein of Bt crystal toxin Cry2Ab, were performed. The knocking down of PxAPN5 in P. xylostella larvae greatly reduced their susceptibility to Cry2Ab and led to a decrease of Cry2Ab binding to P. xylostella midgut. Four truncated fragments of PxAPN5 were further constructed and expressed in Escherichia coli (E.coli) to find the binding region of PxAPN5 to Cry2Ab. The ligand blot result indicated that D1 domain (residues 1-262) and D3 domain (residues 510-620) of PxAPN5 could specially bind to Cry2Ab. Copyright © 2017 Elsevier B.V. All rights reserved.

Favored use of anti-predator netting (APN) applied for the farming of clams leads to little benefits to industry while increasing nearshore impacts and plastics pollution.

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Bendell, L I

2015-02-15

An overview of the efficacy of anti-predator netting (APN) used by the shellfish industry is presented. There is little support that the currently favored APN effectively protects farmed clams from predators. Evidence does suggest that APN leads to impacts and pollution. APN is an attractant for predators, e.g., crabs, by providing a refuge within Ulva sp. which attaches onto the surface of APN. APN entrains silt and organic matter and increases sediment temperatures degrading habitat underneath the APN. APN present hazards to fish and wildlife and is a source of plastics to the marine environment. The continued use of ineffective APN does not serve either the environment or industry well, and many of these issues could be addressed through the alternate use of "ancient" technology used by aboriginal people to maintain clam gardens; building of rock walls optimizing the amount of clam habitat thereby increasing numbers without the use of APN. Copyright © 2015 Elsevier Ltd. All rights reserved.

[Being cared for and caring: living with multiple chronic diseases (Leila)-a qualitative study about APN contributions to integrated care].

Science.gov (United States)

Müller-Staub, Maria; Zigan, Nicole; Händler-Schuster, Daniela; Probst, Sebastian; Monego, Renate; Imhof, Lorenz

2015-04-01

Living with multiple chronic diseases is complex and leads to enhanced care needs. To foster integrated care a project called "Living with chronic disease" (Leila) was initiated. The aim was to develop an Advanced Practice Nursing (APN) service in collaboration with medical centers for persons who are living with multiple chronic diseases. The following research questions were addressed: 1. What are patients' experiences, referring physicians and APNs with the Leila-Service? 2. How are referral processes performed? 3. How do the involved groups experience collaboration and APN role development? A qualitative approach according grounded theory of Corbin and Strauss was used to explore the experiences with the Leila project and the interaction of the persons involved. 38 interviews were conducted with patients who are living with multiple chronic diseases, their APN's and the referring physicians. The findings revealed "Being cared for and caring" as main category. The data demonstrated how patients responded to their involvement into care and that they were taken as serious partners in the care process. The category "organizing everyday life" describes how patients learned to cope with the consequences of living with multiple chronic diseases. "Using all resources" as another category demonstrates how capabilities and strengths were adopted. The results of the cooperation- and allocation processes showed that the APN recognition and APN role performance have to be negotiated. Prospective APN-services for this patient population should be integrated along with physician networks and other service providers including community health nursing.

Sonolência excessiva diurna, apnéia do sono tipo central e distrofia miotônica

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Rubens Reimão

1985-12-01

Full Text Available São relatados dois casos de distrofia miotônica acompanhada de sonolência excessiva diurna. A avaliação polissonográfica de noite inteira revelou grande número de apnéias do sono tipo central deflagrando despertares freqüentes. As apnéias dos tipos obstrutivo e misto ocorreram em níveis normais e não se constatou hipoxia. Houve diminuição da eficiência do sono e redução dos estágios 3, 4 e REM. A apnéia central e a sonolência diurna que acarreta representariam manifestações precoces do comprometimento do sistema nervoso central na distrofia miotônica.

The effect of modified benchmark on the accuracy of measuring the deformation at Muria

International Nuclear Information System (INIS)

Ari Nugroho

2013-01-01

The monitoring of deformation surrounding the Muria mountain is recommended by The IAEA (International Atomic Energy Agency). In addition, this study also to provide the data of deformation caused by the volcanic activity of Mount Muria, as a basic study in analyzing the volcanic hazard toward the NPP (Nuclear Power Plant). The main purpose of this study is to discover the accuracy between the two measurements by using the different BM (Benchmark). This study uses geodetic GPS (Global Positioning System) Trimble R7 GNSS. The measurement in the month of April to July 2011 used the standard BM and conducted in eight BM which are BKI (Bopkri), UJW (Ujung Watu), PDP (Perdopo), RTW (Rahtawu), RGG (Rengging), KTP (Ketek Putih), CRG (Cranggang), DM (Danyang Mulyo) and refer to one reference BM named Mijen. The measurement in the month of November 2011 used the modified BM and conducted in six BM which are BKI, PDP, RTW, RGG, KTP, CRG referred to the same reference BM named Mijen. These measurements resulted data in the range of 4-7 mm (horizontal), 16-28 mm (vertical), and in the range of 0.6 mm - 1.3 mm (horizontal), 0.3 mm – 0.6 mm, respectively. (author)

The Osteogenesis Effect and Underlying Mechanisms of Local Delivery of gAPN in Extraction Sockets of Beagle Dogs

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Hu, Hongcheng; Pu, Yinfei; Lu, Songhe; Zhang, Kuo; Guo, Yuan; Lu, Hui; Li, Deli; Li, Xuefen; Li, Zichen; Wu, Yuwei; Tang, Zhihui

2015-01-01

A plastic and biodegradable bone substitute consists of poly (l-lactic-co-glycolic) acid and 30 wt % β-tricalcium phosphate has been previously fabricated, but its osteogenic capability required further improvement. We investigated the use of globular adiponectin (gAPN) as an anabolic agent for tissue-engineered bone using this scaffold. A qualitative analysis of the bone regeneration process was carried out using μCT and histological analysis 12 weeks after implantation. CBCT (Cone Beam Computed Tomography) superimposition was used to characterise the effect of the different treatments on bone formation. In this study, we also explored adiponectin’s (APN) influence on primary cultured human jaw bone marrow mesenchymal stem cells gene expressions involved in the osteogenesis. We found that composite scaffolds loaded with gAPN or bone morphogenetic protein 2 (BMP2) exhibited significantly increased bone formation and mineralisation following 12 weeks in the extraction sockets of beagle dogs, as well as enhanced expression of osteogenic markers. In vitro investigation revealed that APN also promoted osteoblast differentiation of primary cultured human jaw bone marrow mesenchymal stem cells (h-JBMMSCs), accompanied by increased activity of alkaline phosphatase, greater mineralisation, and production of the osteoblast-differentiated genes osteocalcin, bone sialoprotein and collagen type I, which was reversed by APPL1 siRNA. Therefore, the composite scaffold loaded with APN exhibited superior activity for guided bone regeneration compared with blank control or Bio-Oss® (a commercially available product). The composite scaffold with APN has significant potential for clinical applications in bone tissue engineering. PMID:26492241

The Osteogenesis Effect and Underlying Mechanisms of Local Delivery of gAPN in Extraction Sockets of Beagle Dogs

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Hongcheng Hu

2015-10-01

Full Text Available A plastic and biodegradable bone substitute consists of poly (l-lactic-co-glycolic acid and 30 wt % β-tricalcium phosphate has been previously fabricated, but its osteogenic capability required further improvement. We investigated the use of globular adiponectin (gAPN as an anabolic agent for tissue-engineered bone using this scaffold. A qualitative analysis of the bone regeneration process was carried out using μCT and histological analysis 12 weeks after implantation. CBCT (Cone Beam Computed Tomography superimposition was used to characterise the effect of the different treatments on bone formation. In this study, we also explored adiponectin’s (APN influence on primary cultured human jaw bone marrow mesenchymal stem cells gene expressions involved in the osteogenesis. We found that composite scaffolds loaded with gAPN or bone morphogenetic protein 2 (BMP2 exhibited significantly increased bone formation and mineralisation following 12 weeks in the extraction sockets of beagle dogs, as well as enhanced expression of osteogenic markers. In vitro investigation revealed that APN also promoted osteoblast differentiation of primary cultured human jaw bone marrow mesenchymal stem cells (h-JBMMSCs, accompanied by increased activity of alkaline phosphatase, greater mineralisation, and production of the osteoblast-differentiated genes osteocalcin, bone sialoprotein and collagen type I, which was reversed by APPL1 siRNA. Therefore, the composite scaffold loaded with APN exhibited superior activity for guided bone regeneration compared with blank control or Bio-Oss® (a commercially available product. The composite scaffold with APN has significant potential for clinical applications in bone tissue engineering.

Clinical significance of determination of changes of serum APN, BNP and ANF levels after treatment in patients with heart failure

International Nuclear Information System (INIS)

Ge Hengsong; Hu Min; Gao Xinchun

2011-01-01

Objective: To explore the significance of changes on serum APN, BNP and ANF levels after treatment in patients with heart failure. Methods: Serum BNP, ANF(with RIA) serum APN (with ELISA) levels were determined in 30 patients with heart failure both before and after treatment as well as in 35 normal controls. Results: Before treatment, serum APN level was significantly lower than those in controls (P<0.01), but serum BNP, ANF levels were apparently higher (P<0.01). After 1 month of treatment, the levels dropped markedly, but still remained obviously higher (P<0.05). Conclusion: Serum APN, BNP and ANF levels were closely related to the process of heart failure and were of clinical value of monitoring therapeutic effect and prognosis. (authors)

Mercury in the River Basin Muriaé the stretch between the towns of Patrocínio de Muriaé and Itaperuna in the states of Minas Gerais and Rio de Janeiro, Brazil

International Nuclear Information System (INIS)

Meneses Silva, M. de; Teixeira de Andrade, G.

2010-01-01

The objective of this work is to study the environment contamination by mercury in the current sediments and alluvial plain sediments in the course of Muriaé River (between towns of Patrocinio de Muriaé (MG) – Itaperuna (RJ)) in Minas Gerais and Rio de Janeiro States where occurred the extraction of gold using the process of amalgamation by mercury during eighties and the beginning of the nineties. The methodology used was based in total and sequential extraction. The results in parts per billion (ng.g-1) showed that the total mercury ranged from 222,9 to 761,9 ng.g-1 in the current sediments et 233,6 to 2131,9 ng.g-1 in the alluvial plain sediments. Comparing theses values with the background of region (170 ng.g-1 to 365 ng.g-1) only two of the samples showed results according to this background. The others showed results above this interval. It was observed that when it comes to the availability of mercury to the aquatic environment and biota, 1% to 26,2% of the total mercury is in the exchangeable phase, easily available for the environment, 52,3% to 90,4 % is potentially available (in the oxidizable phase) and 0,2 % to 40 % is inert, imprisoned in the mineral's structure of the sediments ( residual phase)

The Identification of Financing Strategy for the Construction of NPP Type Opr-1000 at Muria Peninsula

International Nuclear Information System (INIS)

Moch-Djoko Birmano

2006-01-01

The study for identification of financing strategy for the construction of OPR-1000 at Muria Peninsula have been done. This study is continuation of previous study with title T he Economic and Financing Viability of the OPR-1000 Construction at Muria Peninsula . In the previous study have been the economic and financing viability of OPR-1000 construction. The economic viability was known by obtained the generation cost, electricity tariff and construction cost. The meanwhile, the financing viability was known by obtained Net Present Value (NPV), Internal Rate of Return (IRR) and Payback Period (P) by using KEPCO Spread Sheet. From the calculation of economic and financing viability in base case, have been obtained the result of electricity tariff, IRR, FNPV and Payback Period for total investment is 6.640 cent/kWh (after Value Added Tax), 10.37%, US$ 90.52 million and 12.11 years, respectively. From this result of economic and financing viability in base case, have been carried out sensitivity analysis to technical parameter (capacity factor) and economic parameter (discount rate). The result of sensitivity analysis to be used for identifying financing strategy in order to obtain the best and optimal economic and financing viability. (author)

68Ga-DOTA-NGR as a novel molecular probe for APN-positive tumor imaging using MicroPET.

Science.gov (United States)

Zhang, Jun; Lu, Xiaoli; Wan, Nan; Hua, Zichun; Wang, Zizheng; Huang, Hongbo; Yang, Min; Wang, Feng

2014-03-01

Aminopeptidase N (APN) is selectively expressed on many tumors and the endothelium of tumor neovasculature, and may serve as a promising target for cancer diagnosis and therapy. Asparagine-glycine-arginine (NGR) peptides have been shown to bind specifically to the APN receptor and have served as vehicles for the delivery of various therapeutic drugs in previous studies. The purpose of this study was to synthesize and evaluate the efficacy of a (68)Ga-labeled NGR peptide as a new molecular probe that binds to APN. NGR peptide was conjugated with 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA) and labeled with (68)Ga at 95°C for 10 min. In vitro uptake and binding analysis was performed with A549 and MDA-MB231 cells. Biodistribution of (68)Ga-DOTA-NGR was determined in normal mice by dissection method. (68)Ga-DOTA-NGR PET was performed in A549 and MDA-MB231 xenografts, and included dynamic and static imaging. APN expression in tumors and new vasculatures was analyzed by immunohistochemistry. The radiochemical purity of (68)Ga-DOTA-NGR was 98.0% ± 1.4% with a specific activity of about 17.49 MBq/nmol. The uptake of (68)Ga-DOTA-NGR in A549 cells increased with longer incubation times, and could be blocked by cold DOTA-NGR, while no specific uptake was found in MDA-MB231 cells. In vivo biodistribution studies showed that (68)Ga-DOTA-NGR was mainly excreted from the kidney, and rapidly cleared from blood and nonspecific organs. MicroPET imaging showed that high focal accumulation had occurred in the tumor site at 1 h post-injection (pi) in A549 tumor xenografts. A significant reduction of tumor uptake was observed following coinjection with a blocking dose of DOTA-NGR, whereas only mild uptake was found in MDA-MB231 tumor xenografts. Tumor uptake, measured as the tumor/lung ratio, increased with time peaking at 12.58 ± 1.26 at 1.5 h pi. Immunohistochemical staining confirmed that APN was overexpressed on A549 cells and neovasculature. (68)Ga

Clinical significance of changes of serum APN, plasma VEGF, Hcy and urine albumin levels in patients with DM2 nephrosis

International Nuclear Information System (INIS)

Zhang Yuejin; Zhang Xinfang; Hu Ying

2011-01-01

Objective: Explore type 2 diabetes mellitus (DM2) and complicating with kidney disease patients homocysteine (Hcy), adiponectin (APN), vascular endothelial growth factor (VEGF) and urine albumin change relations. Methods: A normal controls and no complications of diabetes groups, combined with nephropathy. A comparison were measured of serum APN, plasma VEGF, Hcy and urine albumin level among. Results: Two groups of patients with diabetes fasting blood glucose level were no significant difference. Also there is no difference of BUN and Cr in three groups urine albumin in diabetic-nephropathy albumin increased significantly (P<0.01), than without complications group. Three groups of Hcy concentrations were significantly higher than that of normal control group (P<0.01), serum APN, plasma VEGF level obviously lower than normal control group, which increased in patients with nephropathy increased or reduced more apparently no complications group also have obvious difference (P<0.01). Conclusion: In patients with diabetes in two groups, plasma Hcy and urine albumin were significantly higher APN, and VEGF decreased significantly. In patients with nephropathy manifested more apparently, but renal damage did not enter decompensated period, clinically necessary for people with diabetes testing serum APN, plasma VEGF, Hcy and urine Albumin level, promptly intervention to prevent or relieve the further development of diabetes. (authors)

SCHOOL OBSERVATION AS ONE OF THE ASSESSMENTS FOR ENGLISH EDUCATION DEPARTMENT STUDENTS OF MURIA KUDUS UNIVERSITY

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Atik Rokhayani

2017-04-01

Full Text Available Nowadays, learning requires students to develop their knowledge through critical thinking. Knowledge is not just receiving the information but also interpreting the information. It requires new learning goals change the relationship between assessment and instruction. So, the lecturers need to assess the students’ ability to comprehend the materials. In addition, the lecturers have to take an active role about the purpose of the assessment and the content that is being assessed. There are many kinds of assessments used by the lecturers given to their students. For example: asking the students to do the discussion, test, questioning, observation etc. School observation tends to be familiar for the students of English Education Department of Muria Kudus University since by doing the observation they can face the real school condition. The students can observe the English teaching and learning process in the classroom. This paper focuses in AMEL (Approaches and Methods in English Language class. It discusses the application of school observation as one of the authentic assessment for English Education Department students of Muria Kudus University through exploring the approaches and methods used by Junior High School teachers in Kudus. In the end of the observation, the students have to report the discussion in form of poster presentation.

Developing the role of Swedish advanced practice nurse (APN) through a blended learning master's program: Consequences of knowledge organisation.

Science.gov (United States)

Bergström, Peter; Lindh, Viveca

2018-01-01

This paper reports on a research study conducted with a group of nurses in Sweden enrolled in a newly developed blended learning master's programme to become advanced practice nurses (APNs). As background, the paper presents the regional needs the programme is intended to address and describes how the programme was designed. The aim was to understand how, from students' perspective, the nurse master's programme structured knowledge for their future position as APNs. The research question focuses on how the master's programme prepares students by meeting their diverse needs for knowledge. Empirical material was collected at two times during the students' first and second years of study through semi-structured qualitative interviews. The findings highlight the process in which these master's students gained a more advanced identity of becoming APNs. This process demonstrates how students perceive their current position as nurses based on a discourse of knowledge in relation to the practical and theoretical knowledge they encounter in the master's programme. This article concludes by recommending that attention should be paid to developing APN role models in the current Swedish healthcare system. Copyright © 2017 Elsevier Ltd. All rights reserved.

APNs taking the next step: disseminating practice information via effective poster presentations.

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Bischof, Janet

2013-02-10

Advanced practice nurses (APNs) have a responsibility to share information from projects and research with other professionals. Poster presentations offer a way to visually share the information to a wide audience. Key elements include title, objective/purpose, data collection, results, analysis, implications for nursing, and appropriate references.

[Quality of advanced practice nurse counseling in home care settings (APN-BQ): psychometric testing of the instrument].

Science.gov (United States)

Petry, Heidi; Suter-Riederer, Susanne; Kerker-Specker, Carmen; Imhof, Lorenz

2014-12-01

Patient centred and individually-tailored counselling of older people with a chronic condition who live at home is a useful intervention to support their independence. The paper presents the development and psychometric testing of the APN-BQ Instrument, to measure patient-centeredness. To measure the quality of an in-home counselling intervention, a 23-item questionnaire was developed and tested with 206 people 80 years and older. Principal component analysis with Varimax Rotation was conducted (n = 206). Analysis revealed a four factor (fs = 0.91) model scoring in 19 items. All factors loaded > 0.45. Cronbach's alpha was 0.86. The utility and acceptance of the instrument was confirmed by the high response rate (100 %) and the fact that participants answered 98.8 % of all questions. The APN-BQ has shown to be a reliable Instrument with good content and construct validity. It is a tool for APNs to measure structure, process, and outcome quality of a patient-centred and individually-tailored counselling program, including the degree of patient participation, and patient empowerment.

Measurement and Elemental Analysis of Muria Sea Water for Primary Water of PWR

International Nuclear Information System (INIS)

Dwi Biyantoro; Kris Tri Basuki

2007-01-01

Treatment process of water of free mineral and study area of processing of sea water to meet the need of water cooling of PWR. Desalination is a separation process used to reduce the dissolved salt content of saline water. All desalination processes involve three liquid streams: the saline feedwater (brackish water or seawater), low salinity product water, and very saline concentrate. Seawater Muria Jepara is feed type 1 with content salt is low and relative suspension and weight metals is low. There are two types of membrane process used for desalination: reverse osmosis (RO) and electrodialysis (ED). The starting of process is difficult and expensive. However, starting since 1950, desalination process appear to be economically practical for ordinary use. There are 3 key elements significantly affect to the technical performance and long term characteristic type, i.e. 1) energy, 2) corrosivity of seawater, and 3) desalination process technology. These elements closely inter related and important for design improvements and technical performance optimization. From the analysis of sea water of gulf Muria Jepara was found as follows : Fe = 0.176 ± 0.012 ppm, Pb = 0.612 ± 0.017 ppm, Cd = 52.567 ± 0.750 ppm, Cu = 0.044 ± 0.005 ppm, Zn = 0.061 ± 0.003 ppm, Mn = 0.057 ± 0.003 ppm, Ca between = 365.256 - 368.654 ppm, Na between = 9572.000 - 9775.000 ppm, Mg between 759.000 - 779.00 ppm and Ni = 0.524 ± 0.005 ppm. Cost production of process using reverse osmosis as around 0.9 - 1 US$/m3, while using electrodialysis is around 1.2 US$/m3, and by using evaporation process or distillation process is around 1.4 - 1.6 US$/m3. (author)

Study on the changes of serum adiponectin (APN), insulin, C-reactive protein (CRP) and leptin levels after one year treatment in patients with type 2 diabetes

International Nuclear Information System (INIS)

Du Tongxin; Wang Zizheng; Wang Shukui; Li Yan; Fu Lei; Lin Yanli; Qu Wei; Qi Shaokang; Tao Xiaojun

2005-01-01

Objective: To investigate the β-cell function status and possible mechanism of insulin resistance in patients with type 2 diabetes through studies on the changes of serum APN, insulin, CRP, leptin, insulin antibody and glutamic acid decarboxylase antibody (GAD-Ab) levels after one year of treatment. Methods: Serum levels of the above four parameters and the positive rate of the two antibodies were measured (with CLIA, ELISA and RIA as appropriately) in 184 patients with type 2 diabetes and 30 controls as well as in 75 patients after one year of treatment. Results: The serum contents of insulin, leptin, CRP, insulin antibody in patients with type 2 diabetes were significantly higher (P<0.01) and APN levels significantly lower (P<0.001) than those in controls. Levels of APN were negatively correlated with those of the other parameters. In the 75 treated patients, levels of those parameters (with the exception of APN and insulin-antibody) decreased significantly. However, the APN levels were significantly increased (vs before treatment, P<0.001). Conclusion: Further study on the dynamic changes of these parameters in the diabetic patients might elucidate certain key-points in the pathogenesis of the disease. (authors)

The Potential Pathways of Radionuclide Transformations On The Location Candidate of Nuclear Power Plants in Muria Peninsula

International Nuclear Information System (INIS)

Simandjuntak, A.G.; Syahrir

1998-01-01

The potential pathways of radionuclide transformations on the location candidate of nuclear power plants in Muria peninsula proposed to explain the potential of radionuclide pathways in the ecosystem to human based on annual effective dose calculations with elimination factor ≥ 1 of dose limit 50 mSv per year. The effective dose equivalent calculations used the program package Genll. The datum found from Bureau of Statistic Centre and NEWJEC was taken into calculations. The result of this study is very useful for radiological impact and environmental impact analysis. (author)

DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis.

Science.gov (United States)

Reinhold, Dirk; Bank, Ute; Täger, Michael; Ansorge, Siegfried; Wrenger, Sabine; Thielitz, Anja; Lendeckel, Uwe; Faust, Jürgen; Neubert, Klaus; Brocke, Stefan

2008-01-01

Multiple sclerosis (MS) is the most frequent demyelinating disease of the central nervous system. Peptidases like dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) play a regulatory role in T cell activation and represent potential targets for the treatment of inflammatory disorders. Synthetic inhibitors of DP IV and/or APN enzymatic activity induce production of the immunosuppressive cytokine TGF-beta1 and subsequently suppress DNA synthesis and Th1 cytokine production of activated human T cells. Compelling evidence has demonstrated that IL-17-producing CD4 cells (Th17) are a major contributor to the pathogenesis of autoimmune inflammation. Here, we report that inhibitors of DP IV-like activity as well as of APN activity inhibit IL-17 production in activated human and mouse T cells. Combining inhibitors of DP IV and APN increases the suppressive effect on T cell specific IL-17 production in vitro compared to a single peptidase inhibitor. In the following, we summarize the evidence for the role of both ectoenzymes in T cell activation in vitro and in vivo and provide a rationale for the use of combined or dual ectopeptidase inhibitors to treat autoimmune diseases like MS.

IMPLEMENTASI POPULATION RESIZING ON FITNESS IMPROVEMENT GENETIC ALGORITHM (PROFIGA) UNTUK OPTIMASI RUTE KUNJUNGAN PROMOSI UNIVERSITAS MURIA KUDUS BERBASIS ANDROID DAN GOOGLE MAPS API

OpenAIRE

Tri Listyorini; Syafiul Muzid

2016-01-01

Tim Promosi Universitas Muria Kudus (UMK) melakukan kunjungan promosi ke sekolah menengah atas pada setiap tahun. Kunjungan tersebut dilakukan ke sekolah-sekolah menengah atas di wilayah Kudus, Jepara, Pati, Demak, Rembang dan Purwodadi. Untuk memudahkan kunjungan, setiap kunjungan dibatasi sekitar 15 (lima belas) sekolah. Namun pada saat melakukan kunjungan, tim tersebut mengalami kesulitan dalam menentukan rute kunjungan sekolah. Hal ini dikarenakan jarak sekolah yang dikunjungi cukup jauh ...

AKTIVITAS HEPATOPROTEKTOR BATANG FIBRAURE TINCTORIA LOUR SECARA IN VIVO

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Ika Fikriah

2012-06-01

Full Text Available Study on Fibraurea tinctoria Lour (FT stems gives information about its traditional utility as  yellow fever treatment. Research of antecedent of FT stem proved that inhibited lipid peroxidation more effective than tocopherol acetate. These study was intended to prove hepatoprotector activity of ethanolic FT stem extract by in vivo. FT stem extract was macerated using absolute ethanol during 5 days that was repeated  3 times . FT stem extract hepatoprotector activity by in vivo was tested using carbon tetrachloride induced hepatotoxicity on Wistar rat. They were given FT stem extract orally once a day at dose 50, 100, and 200 mg/kgBW and Curcumin at dose 50 mg/KgBW as positive control.  After 10 days, all groups were examined liver function (SGOT, SGPT, ALP, liver Malonedialdehide (MDA level by Thiobarbituric acid method,  and liver histopathology by Haemotoxylin-Eosin staining. Group that induced by CCl4 showed significant elevation of SGOT, SGPT and ALT also Liver MDA than group control. FT stem extract treatment inhibited elevation of SGOT, SGPT, ALT and Liver MDA significantly.Qualitative histopathological examination on Group 2 showed extensive fibrosis and necrosis, along with  periportal PMN and lymphocyte infiltration. FT stem extract treatment inhibited pathological change that was induced by CCl4. Dose elevation showed tendency of stronger inhibition on liver cell tissue destruction and inflammation. Key words: Fibraurea tinctoria, hepatoprotector, in vivo   Abstrak Penelusuran secara etnobotani, batang Fibraurea tinctoria Lour (FT digunakan untuk obat sakit kuning. Penelitian pendahuluan batang FT berkemampuan meredam peningkatan lipid peroksidasi secara in vitro yang lebih kuat dibandingkan dengan tokoferol asetat. Membuktikan khasiat ekstrak etanol batang FT sebagai hepatoprotektor secara in vivo. Batang FT dimaserasi dengan etanol absolut selama 3 x 5 hari. Uji hambatan kerusakan hati secara in vivo digunakan model tikus yang

Analysis of the variation levels of APN, insulin, sensitive C-reactive protein and leptin in the serum of patients with type 2 diabetes mellitus

International Nuclear Information System (INIS)

Du Tongxing; Wang Zizheng; Wang Shukui; Qi Shaokang; Tao Xiaojun

2005-01-01

To study the mechanism of pancreatic 13 cell dysfunction and tissue resistance to insulin, and to provide basis for early diagnosis and therapy of the disease, the levels of APN, insulin, sensitive C-reactive protein and leptin in the serum of patients with type 2 diabetes mellitus were determined. Altogether 184 untreatea type 2 diabetes mellitus patients, 30 normal people as the control group, and another 75 type 2 diabetes mellitus patients who have been treated for a year were enrolled in this study. The serum levels of the above indexes were determined by chemiluminescence immunoassay, enzyme immunoassay and radioimmunoassay. The results showed that there were obvious differences in the levels of insulin, leptin, C-reacting protein and insulin antibody between the normal control group and the group of the untreated type 2 diabetes mellitus patients (P<0.01), especially there was significant difference in the level of APN(P<0. 001). Among the 75 type 2 diabetes meltitus patients who have received a year's treatment, all the indexes except for APN and insulin antibody were decreased statistically, while the APN level was increased significantly (P<0.01) than that before the treatment. The determination of markers of type 2 diabetes mellitus is of great significance for its early diagnosis, therapy, prognosis and mechanism research. (authors)

Spreading Design of Radioactivity in Sea Water, Algae and Fish Samples inthe Coastal of Muria Peninsula Area

International Nuclear Information System (INIS)

Sutjipto; Muryono; Sumining

2000-01-01

Spreading design of radioactivity in sea water, brown algae (phaeopyceae)and kerapu fish (epeniphelus) samples in the coastal of Muria peninsula areahas been studied. This research was carried out with designed beside to knowspreading each radioactivity but also spreading design in relation to thecontent of Pu-239 and Cs-137. Samples taken, preparation and analysis basedon the procedures of environmental radioactivity analysis. The instrumentused for the analysis radioactivity were alpha counter with detector ZnS, lowlevel beta counter modified P3TM-BATAN with detector GM and spectrometergamma with detector Ge(Li). Alpha radioactivity obtained of sea water, algaeand fish were the fluctuation form of the natural background. Radionuclide ofPu-239 in samples not detect, because its concentration/radioactivity stillbelow the maximum concentration detection value of Pu-239 for algae and fishwas that 1.10 Bq/g, whereas for sea water was that 0.07 Bq/mL. Result for theradioactivity which give the highest alpha radioactivity obtained on thekerapu fish was that 1.56 x 10 -3 Bq/g, beta radioactivity on sea water wasthat 1.75 x 10 2 mBq/L, gamma radioactivity of K-40 on brown algae was that3.72 x 10 -2 Bq/g and gamma radioactivity of Tl-208 on fish as mentionedabove was that 1.35 x 10 -2 Bq/g. All the peak spectrum gamma energy ofCs-137 do not detect with gamma counter, so there are not the radionuclide ofCs-137 in the samples. Spreading design of radioactivity which occur in thecoastal of Muria peninsula area for alpha radioactivity was found on kerapufish, beta radioactivities on sea water and gamma radioactivity on brownalgae and kerapu fish. (author)

Radioecologycal study of {sup 239/240}Pu in Bangka Island and Muria Peninsula: Determination of {sup 239/240}Pu in marine sediment and seawater as part of baseline data collecting for sitting of candidates of first Indonesia NPP

Energy Technology Data Exchange (ETDEWEB)

Suseno, Heny, E-mail: henis@batan.go.id [Radioactive Waste Technology Center - The Indonesian National Nuclear Energy Agency (Indonesia); Wisnubroto, Djarot S. [The Indonesian National Nuclear Energy Agency (Indonesia)

2014-03-24

Radioisotope Pu-239/240 are alpha emitting nuclides important indicators of radioactive contamination of the marine environment. Global fallout is the main source of plutonium in the marine environment. There are very limited study on {sup 239/240}Pu in Indonesia coastal environments. The data of this radioisotopes is needed for baseline data of nuclear power plant (NPP) site candidates both in Bangka Island and Muria Peninsula. Bottom sediments play an important role in radioecological studies of the marine environment because a large proportion of radioactive substances entering the sea is adsorbed over time onto suspended particulate matter and deposited in sediments. Plutonium is particle reactive and deposited in marine sediment. Radioisotope {sup 239/240}Pu was determinated by alpha spectrometry after radiochemical procedure that was performed in both water and marine sediment from Bangka Island and Muria Peninsula. The sediment baseline of concentration {sup 239/240}Pu in Bangka Island and Muria Peninsula were range from 0.013 to 0.021 Bq.kg{sup −1} and 0.018 to 0.024 Bq.kg{sup −1} respectively. The water baseline concentration this isotope were range from 2.73 to 4.05 mBq.m{sup −3} and 2.98 to 4.50 mBq.m{sup −3}.

Bounds on the degree of APN polynomials: the case of x −1 + g(x)

DEFF Research Database (Denmark)

Leander, Gregor; Rodier, François

2011-01-01

In this paper we consider APN functions $${f:\\mathcal{F}_{2^m}\\to \\mathcal{F}_{2^m}}$$ of the form f(x) = x −1 + g(x) where g is any non $${\\mathcal{F}_{2}}$$-affine polynomial. We prove a lower bound on the degree of the polynomial g. This bound in particular implies that such a function f is AP...

Ekstraksi Kata Dasar Secara Berjenjang (Incremental Stemming Berbasis Aturan Morfologi untuk Teks Berbahasa Indonesia

Directory of Open Access Journals (Sweden)

Wahyu Hidayat

2017-05-01

Full Text Available Ekstraksi kata dasar atau stemming pada Bahasa Indonesia adalah proses yang kompleks di mana beberapa partikel awalan dan beberapa partikel akhiran dari 13 awalan, 3 sisipan dan 19 akhiran yang dikenal dapat digunakan secara sekaligus pada sebuah kata. Selain itu, proses stemming tidak selalu menghasilkan 1 kata dasar (non-deterministik, karena terdapat beberapa kata dalam bahasa Indonesia yang memiliki 2 kemungkinan yaitu sebagai kata dasar maupun kata berimbuhan, misalnya pada kata “beruang”. Penelitian yang telah ada sebelumnya menggunakan kombinasi awalan dan akhiran yang tidak mungkin dan menerapkan heuristik untuk memilih kata dasar. Dalam penelitian ini diusulkan sebuah metode stemming secara berjenjang di mana berdasarkan urutan tertentu, secara bergantian partikel akhiran dan awalan dilepaskan dari sebuah kata sehingga dihasilkan sebuah kata dasar. Jika ditemukan beberapa kandidat kata dasar maka salah satu kata dasar akan dipilih. Metode ini diuji pada 6464 dokumen Al-Quran Terjemahan Indonesia dengan menggunakan kamus berukuran 5000 kata yang disampling secara acak dari Kamus Besar Bahasa Indonesia.. Dari 3432 kata unik yang diproses 94,7% kata dasar dapat diekstrak secara langsung dan hanya 5,3% yang perlu diproses lebih lanjut karena kandidat kata dasar yang ditemukan lebih dari satu. Dibandingkan dengan melakukan pemilihan kata dasar secara manual, metode ini dapat  memilih kata dasar yang tepat hingga 79.12%.

Perawatan ortodontik pada kasus periodontitis kronis dengan kerusakan tulang infraboni secara menyeluruh

OpenAIRE

Susanto, Stephanie Adelia; Farmasyanti, Cendrawasih Andusyana; Kuswayuning, Kuswayuning

2016-01-01

Penyakit periodontal merupakan penyakit inflamasi yang mempengaruhi jaringan periodontal dan menyebabkan hilangnya perlekatan jaringan ikat dengan tulang alveolar. Peningkatan kedalaman probing dengan kombinasi faktor usia pasien, onset dan kecepatan perkembangan penyakit, dan kondisi psikologis akan mempengaruhi rencana dan prognosis perawatan. Pergerakan gigi secara ortodontik pada individu dewasa dengan kondisi periodontal perlu disertai dengan kontrol akumulasi plak secara berkala dan pen...

Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13)--a novel approach for the treatment of inflammatory bowel disease.

Science.gov (United States)

Bank, Ute; Heimburg, Anke; Helmuth, Martin; Stefin, Sofia; Lendeckel, Uwe; Reinhold, Dirk; Faust, Jürgen; Fuchs, Petra; Sens, Bianca; Neubert, Klaus; Täger, Michael; Ansorge, Siegfried

2006-12-20

The ectopeptidases Dipeptidylpeptidase IV and Alanyl-Aminopeptidase N, strongly expressed by both, activated and regulatory T cells were shown to co-operate in T cell regulation. Based on the findings that DPIV and APN inhibitors induce the TGF-beta1 and IL-10 production and a suppression of T helper cell proliferation in parallel, and that particularly APN inhibitors amplify the suppressing activity of regulatory T cells, both peptidases represent a promising target complex for treatment of diseases associated with an imbalanced T cell response, such as inflammatory bowel diseases (IBD). The aim of the present study was to analyze the therapeutic potential of DPIV and APN inhibitors in vivo in a mouse model of colitis. Balb/c mice received 3% (w/v) dextran sulphate sodium with the drinking water for 7 days. After onset of colitis symptoms, inhibitor treatment started at day 3. Disease activity index (DAI) was assessed daily, supplemented by histological and immunological analysis. While the DPIV inhibitor Lys-[Z(NO])(2)]-pyrrolidide or the APN-inhibitor Actinonin alone had marked but no significant therapeutic effects, the simultaneous administration of both inhibitors reduced colitis activity in comparison to placebo treated mice, significantly (DAI 4.8 vs. 7.7, pendogenous immunosuppressive mechanisms.

Educating APNs for Implementing the Guidelines for Adolescents in "Bright Futures: Guidelines of Health Supervision of Infants, Children, and Adolescents."

Science.gov (United States)

Porter, Cornelia P.; Pender, Nola J.; Hayman, Laura L.; Armstrong, Myrna L.; Riesch, Susan K.; Lewis, Mary Ann

1997-01-01

Discusses recommendations for preparing advanced practice nurses (APNs) to implement guidelines of a health curriculum: (1) ensuring age-appropriate teaching; (2) emphasizing the complex relationships of race/ethnicity, socioeconomic status, and gender; (3) reinforcing the self-care and resilience of adolescents; and (4) examining transitions…

The effect of time duration in the network and radial method toward the accuracy in measuring the deformation at Muria

International Nuclear Information System (INIS)

Ari Nugroho and Hadi Suntoko

2011-01-01

The Deformation monitoring activities in the vicinity of Mount Muria are recommended by the IAEA (International Atomic Energy Agency) to be done for 5 years. The purpose of these activities is to determine the rate of the deformation caused by the volcanic activity of Mount Muria, as a basic study in analyzing the volcanic hazard toward the NPP (Nuclear Power Plant). The whole coordinate points measured encompass the district of Jepara, Pati, Demak, and Kudus. In 2010 deformation measurements were periodically conducted for 4 times a year using two geodetic GPS units of Trimble R7 GNSS type through the network method. The measurements were carried out at seven points of interest and at one reference point in March, April, May and December. Each session of the measurements was performed for 2.5 hours. In 2011 the deformation measurements were periodically conducted for 4 times a year by means of the radial method. The measurements were made at eight points of interest and at one reference point in April and May, June and July. Each session of measurements was performed for 10 hours. Based on the results of the measurements by means of the network method in 2010, it was concluded that the range of horizontal and vertical accuracy is between 6-10 mm and 25-46 mm, while the results of the measurements of the radial method in 2011 is 4-7 mm, and 16-28 mm respectively. Furthermore, it provides the evidence that the radial method tends to has better result than the network method if it is applied 4 times longer than the network method, resulting the accuracy below 7 mm and 28 mm for horizontal and vertical respectively. (author)

The Analysis of Heavy Metal in Sea Water and Sediment from MuriaPeninsula Coastal Area by NAA Method

International Nuclear Information System (INIS)

TS, Susanna; Sukirno

2000-01-01

The analysis of heavy metal in sea water and sediment taken from Muriacoastal sites in Central Java has been carried out. This research aimed tosupport the EMSB and Ocean Radioecology programme. The sea water sample wasdried with electrical brazier till crystal form, and balanced. Whereas thesediment sample was cleaned, dried at opened air, powdered, screened andhomogenized. Irradiation of samples and standard were done for twelve hoursusing Lazy Susan facility, Kartini reactor with neutron flux of 5.85 x10 10 .n.cm -2 .s -1 . Comparative method of measurements was used foravoiding the effects of neutron flux parameters on the results. Using gammaspectrometer equipment with a Ge(Li) detector and multi channel analyzer with4096 channels, 7 elements were concealed in the sea water; i.e. Fe, Se, Co,Cr, Ce, Sm and Sc were detected, whereas in the sediment sample concealed 10elements were detected, i.e. Fe, Se, Co, Cr, As, Ce, Sm, Th, U and Sc. It wasfound that the elements concentrations in the sediment sample from Muria baywere higher than those elements concentrations in the sea water sample. Theconcentrations of Fe, Se, Co, Cr, Ce, Sm and Sc in the sediment sample fromMuria peninsula coastal area were Fe = 19.923 ± 2.162%, Se = 1.320 ±0.141 ppm, Co = 0.570 ± 0.066 ppm, Cr = 0.410 ± 0.031 ppm, As = 0.500± 0.043 ppm, Ce = 0.774 ± 0.210 ppm, Sm = 1.860 ± 0.210 ppm, Th1.930 ± 0.173 ppm, U = 0.663 ± 0.027 ppm, dan Sc = 0.190 ± 0.003ppm, whereas the concentration elements in the sea water sample were Fe 0.112± 0.007%, Se = 0.305 ± 0.008 ppm, Co = 0.047 ± 0.002 ppm, Cr 0.023± 0.001 ppm, Ce = 0.022 ± 0.001 ppm, Sm = 14 ± 0.8 ppb dan Sc = 2.4ppb, respectively. (author)

Determination of heavy toxic metals in the environment indicator specimens (water, river sediment and kangkung plant) of Muria terrestrial

International Nuclear Information System (INIS)

J Djati Pramana; Sukirno; Bambang Irianto

2004-01-01

Analysis and evaluation contain of heavy toxic metals in the water kangkung plant (Ipomea reptans poir) and river sediment of five rivers sampling location at peninsula Muria region by NAA Instrumental method has been done. The method of sampling. preparation although analysis method according to standard procedure of environmental specimens analysis. Accordingly the quality standard of water group C although group D. the sample from fifth river location sampling was under allowed maximum Cd concentration. Correlation between variable location and kind of indicators to heavy metal concentration was shown by coefficient of Pearson correlation. Interpretation by statistic correlation was obtained. Correlation between kind indicators was indicated that river water has significant correlation with the kangkung plant about Cd concentration. (author)

Penerapan Pasal 1320 KUH Perdata terhadap Jual Beli secara Online (E-Commerce

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Herniwati ,

2015-07-01

Full Text Available Pasal 1320 KUHPerdata mengatur tentang syarat-syarat sah perjanjian. Ketentuan Pasal 1320 ini berlaku terhadap perjanjian jual beli secara konvensional dan perjanjian jual beli melalui online (internet Dewasa ini Perjanjian jual beli melalui online sangat diminati oleh kaum muda dan kaum ibu rumah tangga.Transaksi jual beli secara online atau disebut dengan e-commerce yang dilakukan melalui  media elektronik sudah sangat populer. Para pembeli yang akan membeli barang-barang atau jasa yang ditawarkan oleh penjual (pedagang. Dengan perkembangan teknologi informasi ini akan berdampak terhadap perkembangan aturan-aturan hukum yang ada. Atauran hukum yang diatur dalam KUHPerdata mengatur tentang  syarat-syarat perjanjian. Pasal 1320 KUHPerdata mengatur tentang syarat-syarat sah perjanjian. Ketentuan ini juga berlaku terhadap transaksi jual beli secara online. Ketentuan dalam KUHPerdata ini diperkuat  dengan adanya  Undang-Undang Nomor  11 Tahun 2008 Tentang Informasi dan Transaksi  Elektronik yang mengatur tentang transaksi elektronik.Kata Kunci:  Jual Beli, e-commerce

Genome-wide map of Apn1 binding sites under oxidative stress in Saccharomyces cerevisiae.

Science.gov (United States)

Morris, Lydia P; Conley, Andrew B; Degtyareva, Natalya; Jordan, I King; Doetsch, Paul W

2017-11-01

The DNA is cells is continuously exposed to reactive oxygen species resulting in toxic and mutagenic DNA damage. Although the repair of oxidative DNA damage occurs primarily through the base excision repair (BER) pathway, the nucleotide excision repair (NER) pathway processes some of the same lesions. In addition, damage tolerance mechanisms, such as recombination and translesion synthesis, enable cells to tolerate oxidative DNA damage, especially when BER and NER capacities are exceeded. Thus, disruption of BER alone or disruption of BER and NER in Saccharomyces cerevisiae leads to increased mutations as well as large-scale genomic rearrangements. Previous studies demonstrated that a particular region of chromosome II is susceptible to chronic oxidative stress-induced chromosomal rearrangements, suggesting the existence of DNA damage and/or DNA repair hotspots. Here we investigated the relationship between oxidative damage and genomic instability utilizing chromatin immunoprecipitation combined with DNA microarray technology to profile DNA repair sites along yeast chromosomes under different oxidative stress conditions. We targeted the major yeast AP endonuclease Apn1 as a representative BER protein. Our results indicate that Apn1 target sequences are enriched for cytosine and guanine nucleotides. We predict that BER protects these sites in the genome because guanines and cytosines are thought to be especially susceptible to oxidative attack, thereby preventing large-scale genome destabilization from chronic accumulation of DNA damage. Information from our studies should provide insight into how regional deployment of oxidative DNA damage management systems along chromosomes protects against large-scale rearrangements. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

The Distribution of Heavy Element From Fish, Algae, Water and Sea Sediment In Lemahabang Muria Peninsula

International Nuclear Information System (INIS)

Sukirno; J-Djati-Pramana; Sumining

2005-01-01

The analysis of heavy elements from fish, algae, water and sea sediments in Muria peninsula Jepara has been carried out using neutron activation analysis (NAA) method. Irradiation of sample was carried out for twelve hours with using Lazy Susan facility with neutron flux of 0.585x10 11 n.cm -2 .S -1 . Comparative mode of measurement was used for avoiding the effects of neutron flux parameters on the results. The result on analysis using gamma spectrometry with a Ge(Li) detector showed that there were 6 elements which observed. Those elements contained in algae, fish, water and sea sediment were Co, Sb, Sc, Fe, Cr and Cd. The highest element concentration found in sediment was Fe of 65.625 ± 3.12 % and the lowest was Co of 0.00256 ± 0.00045 μg/g for sea water. This method give precision and relative accuracy of < 10 % for all elements. (author)

Relação entre hipertensão arterial sistêmica e síndrome da apnéia obstrutiva do sono

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Cavallari Fransérgio E.M.

2002-01-01

Full Text Available Introdução: hipertensão arterial sistêmica (HAS e a Síndrome da Apnéia Obstrutiva do Sono (SAOS são doenças prevalentes na população mundial e, embora despertem interesse na comunidade médica, não têm fisiopatologia e mecanismos pelo qual produzem suas complicações completamente elucidados. A SAOS está cada vez mais relacionada a patologias cardiovasculares, principalmente à hipertensão, que é prevalente em pacientes com SAOS. Objetivo: Em nosso estudo, objetivamos avaliar as alterações encontradas na presença de HAS em pacientes portadores de SAOS. Forma de estudo: Clínico prospectivo randomizado. Material e método: Estudamos uma população de pacientes do Ambulatório de Ronco e Apnéia do HC FMRP - USP, de fevereiro de 1999 a fevereiro de 2002, em um total de 42, sendo 30 (71,42% pacientes homens e 12 (28,58% mulheres, com idades de 21 a 77 anos (média de 45,3, dp = 9,372706, todos com diagnóstico de SAOS confirmado pela polissonografia, divididos em dois grupos de 21 pacientes com SAOS (controle e 21 com SAOS e HAS. Avaliamos as escalas de Epworth, Ronco e Sonolência nos dois grupos, além do uso da polissonografia para estudo objetivo. Resultado: Não encontramos diferença estatística entre os grupos na comparação dos resultados das escalas, mesmo tendo o grupo de hipertensos médias maiores. Ao avaliarmos objetivamente os pacientes com a polissonografia, levando em conta o IDR, há estatística significante (p=0,0326, com os hipertensos apresentando médias maiores. Vendo a proporção nos grupos, há predomínio de pacientes com apnéia moderada e grave entre os hipertensos, e leve entre os do controle. Conclusão: Concluindo, a concomitância entre HAS e SAOS representa fator agravante no grau da apnéia.

Correlation of Heavy Element in Sea Water and Sediment Samples from Peninsula of Muria

International Nuclear Information System (INIS)

Rosidi; Sukirno

2007-01-01

The analysis of heavy metals in marine environmental samples peninsula of Muria in the year 2004 has been carried out by using neutron activation analysis (NAA) method. The objective of this analysis is to know the distribution of heavy metals in the sea water and sediment, which accommodate the recent environmental data in supporting the license of site for the nuclear power plants (NPP). The result of the analysis show that there were only 5 observed elements found in sea water and sediment were Cd, Co, Cr, Sb and Sc. All of heavy metals from sea water (0.002 mg/l) are obviously lower than the threshold value established by environmental minister Act; Kep LH No 51/2004. From the observed data to use software of SPSS version 10, application of the Pearson correlation (r) shows that between Co with Sc was indicator show a highly positive significant correlation (r=0.928), between Cr with Sc was sufficiently positive high (r=0.756), between Cr with Cd was precisely (r=0.611) while Co with Sb shows the significantly low (r=0.429). (author)

Correlation of Element Concentration of Cd, Cr, Co and Sc in Sea Water, Fish and Algae Samples from Beach of Lemahabang Muria

International Nuclear Information System (INIS)

Sukirno; Rosidi; Agus Taftazani

2007-01-01

The analysis of Cd, Cr, Co, Sb and Sc element in beach environmental samples Lemahabang Muria in the year 2004 has been carried out by using neutron activation analysis (NAA) method. All of heavy metals from sea water (2.0 μg/l) are obviously lower than the threshold value established by SKRI No 51/2004. From the observed data by Excel application of the correlation value (r) shows that between Cd, Cr, Co, Sb and Sc concentrations from dependent variable of sea water about tree independent variable of kerapu fish, green and brown algae shows a highly positive significant correlation (r > 0.92) except element of Sb was sufficiently positive high (r = 0.66). (author)

Coordination of joint actions in Muriaé’s (MG clothing lpa / Coordenação das ações conjuntas no APL de vestuário de Muriaé-MG

Directory of Open Access Journals (Sweden)

Cecilia Alves da Silva Antero

2016-06-01

Full Text Available Purpose: It sought to understand the coordination of the local production arrangement (LPA, especifically clothing production in the City of Muriaé, MG-Brazil. Originality/gap/relevance/implications: This study proposes the analytical model for comprehending how coordinating happens, as well as indicate relations between the elements that compose it, and the implications for the way in which these elements are manifested in a LPA context. It consists in an advance for understanding governance in LPA. We suggest means for systematizing the coordination of joint actions and mitigating challenges regarding means of production and means of coordinating. Key methodological aspects: A qualitative/descriptive research was performed, whose data was gathered through documents and partially structured interviews, conducted with twenty agents of said LPAs. The data was processed through NVivo® software and categorized by the content analysis technique. Summary of key results: It was found that the coordination is characterized by low levels of formality, integration and participation of the business representatives, management structure made of some entities and average integration and participation levels of the business representatives’ part. Results that support other studies developed about the practice. Key considerations/conclusions: It was identified factors that allow us to grasp the complex reality and dynamics of a LPA, as well as criteria for systematizing and comprehending how coordination happens and pointing out its implication in the development [of local business]. Out of strategies devised, it will be possible to direct the activities of coordinators from others LPAs, fostering local business development Objetivo: Buscou-se compreender a coordenação do arranjo produtivo local (APL de vestuário de Muriaé-MG.Originalidade/Lacuna/Relevância/Implicações: Este estudo contribui ao propor o modelo analítico para compreender a coordena

Comparative study of radiological assessment impact of nuclear power plant and coal-fired power plant: the atmospheric dispersion factor (χ/Q) in Muria Peninsula, Jepara

International Nuclear Information System (INIS)

Umbara, H.; Syahrir; Yatim, S.

1997-01-01

The atmospheric dispersion factor (χ/Q) in Muria Peninsula, Jepara was carried out to calculate the exposure dose to public from nuclear power plant and coal-fired plant. The dispersion factor (χ/Q) value was calculated with mathematical model and diffusion equation. Parameter used as the input data was taken from meteorological data of Ujung Watu site within one year (August 1994 - July 1995) to obtain joint frequency distribution data which were the percentage of wind speed and stability class for 16 sector within one year. The results indicated that the highest dispersion factor (χ/Q) within 300 - 700 m radius from point of release is 4.750E-07 - 8.238E-07 second/m 3 for north west direction (author)

ISOLASI DAN IDENTIFIKASI KHAMIR SECARA MORFOLOGI DI TANAH KEBUN WISATA PENDIDIKAN UNIVERSITAS NEGERI SEMARANG

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Jumiyati -

2012-03-01

Full Text Available Tujuan penelitian untuk mengisolasi dan mengidentifikasi khamir secara morfologi di tanah Kebun Wisata Pendidikan Unnes. Penelitian ini merupakan penelitian eksplorasi yang dilakukan di Laboratorium Mikrobiologi Jurusan Biologi FMIPA Unnes. Populasi penelitian adalah khamir di tanah Kebun Wisata Pendidikan Unnes. Sampel penelitian adalah isolat khamir yang diambil dengan teknik Purposive Sampling yaitu membagi kebun menjadi lima zona dan setiap zona diambil secara acak lima titik pengambilan kemudian dihomogenkan. Sampel dibawa ke Laboratorium untuk dilakukan isolasi, purifikasi dan identifikasi secara morfologi koloni dan sel. Simpulan penelitian ditemukan tujuh isolat khamir dan termasuk ke dalam lima genus yaitu Saccharomyces, Candida, Debaromyces, Brettanomyces dan Saccharomycodes. The purpose of the research was to isolate and to identify morphologically the individually-isolated yeasts from the soil of Biology Educational Garden Semarang State University. The exploration research was conducted in the Microbiology Laboratory Department of Biology, FMIPA Semarang State University. The yeasts were collected using purposive sampling technique in five zones and from each zone five random plots were selected to obtain the samples. Samples were isolated, purified and identified morphologically in terms of the colonies and the cells. Result revealed that seven isolated yeasts from five generas (Saccharomyces, Candida, Debaromyces, Brettanomyces, and Saccharomycodes had been collected from the soil of Biology Educational Garden Semarang State University.

PREPARASI DAN KARAKTERISASI ZEOLIT DARI ABU LAYANG BATUBARA SECARA ALKALI HIDROTERMAL

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Jumaeri Jumaeri

2012-01-01

Full Text Available Preparasi zeolit dari abu layang batubara PLTU Suralaya secara alkali hidrotermal telah dilakukan. Preparasi dilakukan terhadap abu layang yang telah direfluks dengan HCl 1M dan tanpa refluks. Larutan NaOH dengan konsentrasi tertentu ( 1 ; 2 dan 3 M dicampur dengan abu layang batu bara dengan rasio 10 ml larutan tiap 1 gram abu layang, ke dalam tabung Teflon 100 ml dalam suatu autoclave stainless-steel. Autoclave kemudian dipanaskan pada temperature 80-16 oC selama tiga hari. Zeolit sintesis yang dihasilkan selanjutnya diuji secara kualitatif dengan menggunakan Spektroskopi Inframerah, dan Difraksi Sinar-X. Hasil penelitian menunjukkan bahwa aktivasi abu layang dengan proses alkali hidrotermal dapat menghasilkan material yang mempunyai struktur mirip zeolit (zeolit-like. Produk hidrotermal terdiri dari campuran zeolit (Zeolit P, Zeolit Y serta kristal sodalit dan mullit. Pada temperatur 160 oC, diperoleh zeolit dengan kristalinitas lebih tinggi dari pada 100 oC, baik melalui refluks atau tanpa refluks. Karakteristik zeolit yang terbentuk sangat ditentukan oleh kondisi proses, yang meliputi konsentrasi NaOH, waktu, dan temperatur.

The economic and financing viability of the OPR-1000 construction at Muria Peninsula

International Nuclear Information System (INIS)

Moch Djoko Birmano; Mochamad Nasrullah

2005-01-01

The study of the economic and financing viability of the OPR-1000 construction at Muria Peninsula have been done. This study is carried out with steps as follows: updating of newest OPR-1000 technical and economic data; survey of financing sources; the calculation of electricity generation cost, electricity tariff, construction cost of OPR-1000; and calculation of OPR-1000 financing viability by using feasibility criteria such as Net Present Value (NPV), Internal Rate of Return (IRR) and capital payback period. The calculation of generation cost, electricity tariff, construction cost and financing viability criteria (IRR, NPV, Payback Period)by using KEPCO Spread Sheet. From the results of calculations how that the electricity generation cost is 4.0866 cent/kWh, while the electricity tariff is 6.6399 cent/kWh(after Value Added Tax). The total construction cost of OPR-1000 is US $4,092.09 million (included interest and financial fee, excluded initial nuclear fuel). The calculation of financing viability in base case obtained that value of IRR, NPV and Payback Period for total investment is 10.37%. US$90.52 million and 12.11 years respectively. From these results can be concluded that with the electricity tariff of 6.640 cent/kWh or 0.0664 US$/kWh, basically this project of OPR-1000 construction is very feasible and beneficial. From investment side, this project can attract investor because the rate of capital return is high enough, profit in the end of economic life is big enough and payback period is short. (author)

PENGGUNAAN AUGMENTED REALITY UNTUK MENSIMULASIKAN DEKORASI RUANGAN SECARA REAL TIME

OpenAIRE

Ulva Erida Nur Rochmah; Aris Rakhmadi

2016-01-01

Abstrak Mendekorasi ruangan merupakan kegiatan  yang memakan banyak waktu dan tenaga, terutama jika objek yang digunakan besar dan berat. Akan merepotkan jika seseorang harus menggeser setiap objek untuk menentukan letak yang sesuai. Hal ini dapat dihindari dengan menggunakan aplikasi berbasis Augmented Reality. Augmented Reality merupakan sebuah teknologi untuk menggabungkan dunia nyata dan dunia virtual dengan cara menampilkan objek-objek virtual di dunia nyata secara real time. Tujuan uta...

PERAN AYAH DALAM KEBERHASILAN PROGRAM INISIASI MENYUSUI DINI (IMD PADA BAYI YANG LAHIR SECARA SECTIO CESARIA

Directory of Open Access Journals (Sweden)

sestu retno

2016-11-01

Full Text Available ABSTRAK Pendahuluan: Persalinan secara Sectio Cesaria (SC merupakan salah satu kendala untuk melakukan Inisiasi Menyusui Dini (IMD.  Kesiapan ibu yang baru melahirkan untuk memberikan ASInya pada bayi yang baru dilahirkan memerlukan adanya persiapan karena ibu mengalami perubahan peran. Pencapaian peran ibu bisa berhasil bila ibu menjadi dekat dengan bayinya dan mendapatkan dukungan dari suami. Peran suami dalam pelaksanaan IMD adalah sangat penting. Keterlibatan suami dalam pelaksanaan IMD ini meliputi pemberian dukungan dan interaksi. Suami merupakan orang terdekat bagi ibu menyusui yang diharapkan selalu ada di sisi ibu dan selalu siap memberi bantuan. Jika ibu mendapatkan kepercayaan diri dan mendapat dukungan penuh dari suami, motivasi ibu untuk menyusui akan meningkat.Penelitian ini bertujuan untuk mengetahui keterlibatan suami mendampingi istri bersalin secara SC dalam pelaksanaan IMD. Metode: Penelitian ini menggunakan jenis penelitian eksplanatif observasional dengan rancangan cross sectional, bertujuan menggumpulkan data responden untuk menjawab issu strategis yang sedang terjadi, yang menyebabkan ibu post SC tidak melaksanakan IMD. Responden sejumlah 282 ibu post SC yang memenuhi kriteria inklusi dan eksklusi. Tempat penelitian ini dilakukan di  ruang operasi (OK  kebidanan rumah sakit Tipe B, yaitu RSUD Jombang dan RSUD Sogaten Madiun. Hasil: Hasil pengujian secara bersama terdapat pengaruh  dari variabel dukungan suami  dan interaksi suami  terhadap pelaksanaan IMD. Hasil pengujian secara individu terhadap variabel dukungan suami  terdapat pengaruh  terhadap pelaksanaan IMD, sedangkan pada variabel interaksi suami tidak terdapat pengaruh terhadap pelaksanaan IMD.  Pelaksanaan IMD dipengaruhi oleh dukungan suami sebesar 3,7%. Diskusi: Ibu yang didukung suami lebih termotivasi untuk melaksanakan IMD kepada bayinya. Kata kunci: persalinan sectio cesaria, Inisiasi Menyusui Dini (IMD

Sistem Pengendali Peralatan Elektronik dalam Rumah secara Otomatis Menggunakan Sensor PIR, Sensor LM35, dan Sensor LDR

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Eka Desyantoro

2015-08-01

Full Text Available Listrik merupakan hal yang sangat penting di kehidupan kita. Setiap pekerjaan kita pasti dibantu dengan adanya listrik. Mulai dari penerangan hingga pengaturan suhu ruangan pun semuanya dibantu oleh listrik. Ketergantungan manusia terhadap listrik ini menimbulkan kebiasaan buruk. Banyak orang yang terkadang membiarkan suatu peralatan elektronik hidup pada saat tidak dibutuhkan. Terjadi suatu permasalahan untuk menciptakan suatu desain sistem embedded untuk mengendalikan peralatan elektronik dalam rumah secara otomatis. Makalah ini membahas tentang perancangan sistem pengendali peralatan elektronik dalam rumah secara otomatis. Sistem terdiri dari sensor PIR yang berfungsi untuk mendeteksi objek bergerak (manusia, sensor LM35 yang berfungsi untuk mendeteksi suhu, dan sensor LDR berfungsi sebagai sensor cahaya. Mikrokontroller ATMega16 sebagai pengendali jalannya sistem dari pembacaan sensor, menampilkan data sensor pada LCD dan mengatur kontak relay untuk menghidup dan mematikan listrik. Sistem pengendali peralatan elektronik dalam rumah secara otomatis menunjukan sensor LDR dapat membedakan gelap dan terang, sensor suhu LM35 dapat mendeteksi suhu dalam ruangan dengan toleransi kesalahan pembacaan kurang lebih 2o Celcius, dan sensor PIR dapat mendeteksi pergerakan manusia sejauh 5 meter.

Distribution of Heavy Metal Elements in the Sea Water, Algae and Fish ofMuria Peninsula Area

International Nuclear Information System (INIS)

Djati-Pramana, J; Agus-Taftazani; Sudarmadji

2000-01-01

Analysis of heavy metal elements in the specimens of sea water, brownalgae and kerapu fish from two area sampling Lemah Abang and Semat beach byINAA method was done. The same of such specimens from Krakal beach was takenfor control specimen. The aim of this investigation was to obtain a part ofinput data for EMSB program. Preparation after sampling was performed asfollows. Sea water sample was concentrated using 1/5 times of the initialvolume. Algae and fish specimens were crushed using N 2 liquid, dried at thefreeze dryer than were homogenized and screened through 100 mesh. The threeof those specimens were irradiated together for 12 hours in the Lazy Susanirradiation facility of Kartini reactor. Flux neutron was 5.85 . 10 10 n/cm 2 .sec. The heavy metal elements that could be identified were Sm, Se,Cr, Zr, Fe and Co. Concentration in the specimens from Muria peninsula wasrelatively higher comparated to control specimens. This might be use to thefound of these indicators to concentrated that of heavy metals from sea wateror their environment which has a higher concentration. From t test for 95 %probability to control specimens was showed that these was a significantdifference from all the detected elements. From the obtained data there was apollution indication in the area at the period of sampling. (author)

The Migration Behaviour of Cesium-137 on the Soils of Muria Peninsula as the Area of Nuclear Power Plant Site's Candidate

International Nuclear Information System (INIS)

Ngasifudin; Herry Purnomo; Endro Kismolo

2002-01-01

The research on kinetic and migration of Caesium-137 on the soils of Muria Peninsula as the area of Nuclear Power Plant site's candidate have been done. The migration process of cesium in soil is influenced by physical and chemical properties of soil and environment in which the sorption process is occurred. These physics and chemical properties data and radionuclide retardation factor in such area are needed on the study of mathematic models of radionuclide migration. The experiment results are, porosity : 0.479 - 0.566; the water flowrate average : 5.91 x 10 -4 - 4.48 X 10 -2 cm/second; the longitudinal dispersivity : 0.030 - 0.241 cm; the coefficient of longitudinal dispersivity : 4.96 x 10 -5 - 7.69 X 10 -3 cm 2 /second and retardation factor : 2.30 - 3.39. The result of minerals content of soils for the depth 0-30 cm in average is in the range of : for sand 53.17%, for clay 10.48%, for dust 36.37% and moisture 2.58%. (author)

Resultados preliminares do tratamento dos pacientes submetidos a radiofreqüência (baixa freqüência, somnoplastia no ronco e apnéia leve do sono

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Dibbern Ralph S.

2002-01-01

Full Text Available Introdução: O ronco afeta 5 a 50% da população tornando-se um problema médico e social importante. O tratamento pode ser com medidas comportamentais, CPAP e cirúrgico. Objetivo: Avaliar os resultados pós-operatórios dos pacientes submetidos à radiofreqüência em palato. Forma de estudo: retrospectivo clínico. Material e método: 28 pacientes submetidos à radio-freqüência em palato, com diagnóstico de Ronco e Apnéia Leve do Sono. Observamos os resultados pós-operatórios através das Escalas de Epworth, Ronco e Sonolência diurna, complicações e percentual de melhora dos sintomas. A análise estatística foi pelo Mann Whytney Test. Resultados: 16 pacientes com melhora subjetiva do Ronco acima de 70% após a cirurgia; 26 pacientes mostraram redução significativa pelas Escalas, com complicações mínimas. Conclusão: Radio-freqüência é um método seguro e eficaz no tratamento do Ronco e Apnéia Leve do Sono. Resultados melhores serão obtidos com avaliação criteriosa pré e pós-operatórias.

Climate and Hydrological Data Analysis for hydrological and solute transport modelling purposes in the Muriaé River basin, Atlantic Forest Biome, SE Brazil

Science.gov (United States)

Santos, Juliana; Künne, Annika; Kralisch, Sven; Fink, Manfred; Brenning, Alexander

2016-04-01

The Muriaé River basin in SE Brazil has been experiencing an increasing pressure on water resources, due to the population growth of the Rio de Janeiro urban area connected with the growth of the industrial and agricultural sector. This leads to water scarcity, riverine forest degradation, soil erosion and water quality problems among other impacts. Additionally the region has been suffering with seasonal precipitation variations leading to extreme events such as droughts, floods and landslides. Climate projections for the near future indicate a high inter-annual variability of rainfall with an increase in the frequency and intensity of heavy rainfall events combined with a statistically significant increase in the duration of dry periods and a reduced duration of wet periods. This may lead to increased soil erosion during the wet season, while the longer dry periods may reduce the vegetation cover, leaving the soil even more exposed and vulnerable to soil erosion. In consequence, it is crucial to understand how climate affects the interaction between the timing of extreme rainfall events, hydrological processes, vegetation growth, soil cover and soil erosion. In this context, physically-based hydrological modelling can contribute to a better understanding of spatial-temporal process dynamics in the Earth's system and support Integrated Water Resourses Management (IWRM) and adaptation strategies. The study area is the Muriaé river basin which has an area of approx. 8000 km² in Minas Gerais and Rio de Janeiro States. The basin is representative of a region of domain of hillslopes areas with the predominancy of pasture for livestock production. This study will present some of the relevant analyses which have been carried out on data (climate and streamflow) prior to using them for hydrological modelling, including consistency checks, homogeneity, pattern and statistical analyses, or annual and seasonal trends detection. Several inconsistencies on the raw data were

Pengaruh Penempatan Sirip Berbentuk Segitiga Yang Dipasang Secara Aligned Dan Staggered Terhadap Performansi Kolektor Surya Pelat Datar

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Ketut Astawa

2016-07-01

Full Text Available Abstrak: Energi surya adalah jenis energi terbarukan yang umum digunakan karena ketersediaannya yang sangat besar. Teknologi pengolah energi surya, salah satunya adalah kolektor surya. Kolektor surya pada umumnya, menggunakan laju aliran massa udara yang secara parallel melewati pelat penyerap. Udara yang masuk inlet akan melewati pelat penyerap dan langsung keluar melalui outlet. Penelitian ini dilakukan untuk membandingkan pengaruh penempatan sirip berbentuk segitiga yang dipasang secara alignedyang mengarah ke atas pada bagian atas pelat penyerap dan staggeredyang mengarah ke bawah pada bagian bawah dari pelat penyerap sehingga akan terjadi aliran udara secara turbulen di dalam kolektor dan dengan penambahan sirip segitiga ini juga dapat memperluas daerah penyerapan panas pada pelat penyerap kolektor surya yang secara langsung memperluas permukaan perpindahan panas dari pelat penyerap ke fluida kerja yang nantinya diharapkan mampu menghasilkan temperatur keluar kolektor yang lebih tinggi dan meningkatkan performansi kolektor surya pelat datar.Penelitian ini dilakukan secara eksperimen, sebagai variable bebas dalam penelitian ini adalah intensitas radiasi matahari dan variabel terikatnya adalah energi berguna dan efisiensi kolektor surya pelat datar.Dari hasil pembahasan penempatan sirip berbentuk segitiga pada kolektor surya pelat datar yang dipasang secara staggered menghasilkan energi berguna dan efisiensi yang lebih besar dibandingkan dengan kolektor surya yang dipasang secara aligned. Dilihat dari rata-rata hariannya energi berguna untuk kolektor bersirip aligned adalah 153.01 Watt dan untuk kolektor bersirip staggered sebesar 157.42 Watt, sedangkan untuk efesiensinya pada kolektor surya bersirip aligned adalah 37.94% dan untuk kolektor bersirip staggered42.12 %.Kata kunci : Performansi kolektor surya pelat datar, sirip segitiga aligned, sirip segitiga staggered Abstract: Solar energy is a type of renewable energy that is commonly used

Analysis of Fe, Ca, Ti, Ba, Ce, Zr and La element in the Sea sediment at Muria peninsula by X RF method

International Nuclear Information System (INIS)

Sukirno and Sri Murniasih

2009-01-01

he analysis of metals (Fe, Ca, Ti, Ba, Ce, Zr and La) in the sea sediment environmental samples at Muria peninsula has been carried out with X-Ray Fluorescence (XRF) method. The aim of this analysis is to know the distribution metals which accommodate the recent environmental data in supporting the license of site and Environmental Impact Assessment (EIA) for the Nuclear Power Plants (NPP). Samples taken preparation and analysis based on the procedures of environmental analysis. The result analysis that contents of mayor elements in 7 sea sediment location of sampling were Ca, Ti and Fe with concentration are (6.74 – 11.69 ) %; (0.74 – 6.89 ) % and (0.45 -1.94 ) % successively; while minor elements were Ba, Ce, Zr and La with concentration are 451.4 – 1331.6 ) mg/kg; (201.8 – 427.3) mg/kg; (192.3 – 338.5) mg/kg dan (171.7 – 298.4) mg/kg. The statistic test result shows that sampling location there is a significant difference all of element with the level significant of 95 %. (author)

Pola Penguasaan Tanah Sawah secara Sistem Gilir Ganti pada Masyarakat Hukum Adat Kerinci

OpenAIRE

Idris, Isran

2011-01-01

Sistem gilir ganti sawah adalah pola penguasaan tanah sawah menurut Hukum Adat Kerinci. Sistem ini memberikan bagi ahli waris perempuan untuk secara bergilir ganti dalam menggunakan atau pemakaiannya guna mendapatkan hasilnya. Adanya sistem ini adalah pengaruh sistem kewarisan yang membedakan antara harta berat dan ringan. Banyaknya peserta dan persilangan gilir ganti sawah mempengaruhi pergerakan sistem dan masa tunggu setiap peserta untuk mendapatkan gilirannya.

Mapeamento das áreas de risco de inundação com a utilização do modelo digital de elevação hidrologicamente consistente: estudo de caso em Muriaé

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Nelson Avelar Guimarães

2009-08-01

Full Text Available A inundação de áreas urbanas tem sido um grave problema que vários municípios têm enfrentado nos últimos anos, em períodos de chuvas. A ocupação do solo no município de Muriaé - MG, tem-se dado de maneira bastante desordenada e dirigindo-se principalmente para as regiões planas, especialmente para as áreas de inundação do rio Muriaé. A motivação para este estudo surgiu da necessidade de fornecer informações para o processo de tomada de decisão por parte do administrador municipal no sentido de suas políticas públicas. Por esta razão, foi gerado um Modelo Digital de Elevação Hidrologicamente Consistente (MDEHC, a partir de um levantamento planialtimétrico para a caracterização do relevo. De posse do MDEHC foram realizadas simulações, variando altitudes de inundações com o objetivo de determinar quais os bairros que seriam afetados e suas respectivas áreas. Outra análise constitui em realizar a interseção do mapa de imóveis do município com as simulações para determinar o número de residências atingidas pelas inundações simuladas. Os resultados mostraram alta suscetibilidade do perímetro urbano à inundação, em especial o bairro Barra, que para a simulação de uma inundação de 192 metros de altitude, apresentou 27,46% de sua área inundada e cerca de 1440 imóveis atingidos. A metodologia aplicada neste estudo mostrou-ser satisfatória desde que os dados necessários para a caracterização de relevo sejam confiáveis.

Ocorrência de complicações crônicas e seus fatores de risco em pacientes diabéticos atendidos pelo Programa Saúde da Família de Muriaé, MG, Brasil

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Pedro Paulo Pedrosa NETTO

2015-01-01

Full Text Available O objetivo deste trabalho foi analisar a ocorrência de complicações associadas ao diabetes e identificar seus fatores de risco em indivíduos com diabetes mellitus assistidos pelo Programa Saúde da Família de Muriaé-MG. Foi realizado um estudo quantitativo, transversal no período de fevereiro a junho de 2009 na unidade do Programa de Saúde da Família (PSF do bairro São Gotardo no município de Muriaé, MG. A amostra foi constituída por 50 pacientes. As informações de cada participante foram obtidas por meio de um questionário estruturado. As informações sobre a ocorrência de complicações crônicas do diabetes foram obtidas por meio da análise dos prontuários dos pacientes. Foi observado que 23 (46,0% pacientes não apresentavam complicação da doença, enquanto 27 (54,0% apresentavam pelo menos uma complicação, sendo as mais frequentes retinopatia, presente em 18 (66,67% pacientes, doenças cardiovasculares (14, 51,85% e neuropatia diabética (11, 40,74%. Os fatores de risco mais prevalentes foram sedentarismo (39, 78,0%, obesidade central (7, 74,0% e HAS (35, 70,0%. Ainda são necessários grandes esforços na atenção primária ao paciente diabético com relação ao tratamento adequado da doença e à adesão de hábitos de vida saudáveis, pois a presença de complicações associadas ao estado de saúde geral dos pacientes diabéticos diminui significativamente a qualidade de vida desta população.

PENGEMBANGAN APLIKASI MANAJEMEN PROYEK SECARA GRAFIS BERBASIS WEB MENGGUNAKAN METODE DIAGRAM PRESEDENSI

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Suhadi Lili

2004-07-01

Full Text Available Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Dalam kegiatan manajemen proyek diperlukan koordinasi yang bagus dan kerjasama tim yang kompak antar divisi pelaksana proyek. Selama ini, secara kovensional untuk membuat perencanaan proyek maupun melakukan review dan evaluasi jalannya proyek, perlu diadakan rapat atau pertemuan langsung dari orang-orang yang berperan sebagai manajer dan perencana. Para manajer profesional ini seringkali adalah orang-orang yang mobilitasnya tinggi sehingga tidak selalu berada ditempat pada saat dibutuhkan, sehingga koordinasi proyek akan terhambat dan menjadi tidak efisien. Dengan adanya kemajuan teknologi pada saat ini khususnya internet, permasalahan tersebut sangat memungkinkan untuk diselesaikan dengan menyediakan perangkat lunak yang dikhususkan untuk manajemen proyek, yang bisa diakses online secara multiuser dengan pendekatan sifat real time sehingga para manajer dapat melakukan kolaborasi kerja di mana saja mereka berada selama tersedia perangkat komputer yang terhubung dengan internet. Penelitian ini bertujuan untuk membuat perangkat lunak tersebut. Dalam Teknik Informatika, aplikasi seperti ini merupakan aplikasi terdistribusi, karena itu idealnya harus dibuat bersifat portabel agar dapat berjalan pada semua sistim

Dieta hipocalórica e treinamento físico em pacientes com síndrome metabólica e apnéia do sono

OpenAIRE

Cristiane Maki Nunes

2011-01-01

INTRODUÇÃO. Estudos anteriores demonstraram que pacientes com síndrome metabólica (SMet) e apnéia obstrutiva do sono (SAOS) apresentam hiperativação simpática e hipersensibilidade quimiorreflexa. Neste trabalho, testamos as hipóteses de que: 1) dieta hipocalórica associada à treinamento físico (D+TF) melhora a sensibilidade quimiorreflexa em pacientes com SMet e 2) Os efeitos da D+TF seriam mais pronunciados em pacientes com SMet+AOS que em pacientes sem AOS (SMet-AOS). MÉTODOS. Vinte e sete ...

Pola Penguasaan Tanah Sawah Secara Sistem Gilir Ganti pada Masyarakat Hukum Adat Kerinci

OpenAIRE

Idris, Isran

2011-01-01

Sistem gilir ganti sawah adalah pola penguasaan tanah sawah menurut Hukum Adat Kerinci. Sistem ini memberikan  bagi ahli waris perempuan untuk secara bergilir ganti dalam menggunakan atau pemakaiannya guna  mendapatkan hasilnya. Adanya sistem ini adalah pengaruh sistem kewarisan yang membedakan antara harta berat dan ringan. Banyaknya peserta dan persilangan gilir ganti sawah mempengaruhi pergerakan sistem dan masa tunggu setiap peserta untuk mendapatkan gilirannya.   Kata kunci: sistem gilir...

EFEK VITAMIN C DALAM MEDIUM DMEM TERHADAP PERTUMBUHAN SEL PARU-PARU FETUS HAMSTER SECARA IN VITRO

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Ema Kurnia W,

2012-09-01

Full Text Available Penelitian ini dilakukan dengan tujuan untuk mengetahui efek vitamin C dalam medium DMEM terhadap pertumbuhan sel paru-paru fetus hamster secara in vitro dan untuk mengetahui pada konsentrasi berapakah vitamin C dalam medium DMEM yang berpengaruh paling efektif terhadap pertumbuhan sel paru-paru fetus hamster secara in vitro. Penelitian ini merupakan penelitian eksperimental dengan 6 perlakuan dan 2 ulangan. Masing-masing perlakuan tersebut adalah vitamin C dengan konsentrasi 0mM (kontrol, 5mM, 10mM, 15mM, 20mM, dan 25mM. Vitamin C dengan berbagai konsentrasi tersebut ditambahkan ke dalam medium DMEM dan selanjutnya digunakan untuk menumbuhkan sel paru-paru fetus hamster. Sel paru-paru fetus hamster diisolasi dari fetus hamster berumur 2 hari, ditumbuhkan dalam medium DMEM yang sudah ditambah dengan vitamin C dengan berbagai konsentrasi dan diinkubasi dalam inkubator CO2 5% pada suhu 370C selama beberapa hari sampai biakan sel-sel tersebut konfluen. Setelah konfluenbiakan sel diamati persentase konfluen, viabilitas dan abnormalitas sel. Hasil penelitian menunjukkan bahwa vitamin C dengan konsentrasi 0mM (kontrol, 5mM, 10mM, 15mM, 20mM, dan 25mM dalam medium DMEM mampu menghasilkan persentase konfluen berturut-turut 50%, 65%, 72.5%, 82.5%, 87.5%, dan 92.5% dan persentase viabilitas sel sebesar 89%, 94.5%, 94%, 93%, 94%, dan 96.5%. Sedangkan konsentrasi vitamin C yang efektif terhadap pertumbuhan sel paru-paru fetus hamster secara in vitro adalah konsentrasi 25mM.

Analisa Dimensi Website Yang Mempengaruhi Keputusan Konsumen Surabaya Dalam Melakukan Reservasi Hotel Secara Online

OpenAIRE

Sosiawan, Marchella; Sandhika, Vicky Violetta

2016-01-01

Penelitian ini ditujukan untuk menganalisa dimensi website yang mempengaruhi keputusan konsumen Surabaya dalam melakukan reservasi hotel secara online. Penelitian ini menggunakkan analisa faktor, hasil penelitian menunjukan 8 faktor baru yaitu dimensi Access (1), Safety and Privacy (2), Marketing (3), Navigation (4), Clarity of Information (5), Personalization (6), Service (7), dan Accurancy (8). Sebagai faktor dari dimensi website yang mempengaruhi konsumen untuk melakukan reservasi hotel s...

UJI ZONA HAMBAT EKSTRAK DAUN PUTRI MALU (Mimosa pudica TERHADAP BAKTERI Staphylococcus aureus DAN Methicillin-resistant Staphylococcus aureus (MRSA SECARA IN VITRO

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Nyoman Ririn Chandrika Sari

2015-04-01

Full Text Available Resistensi Staphylococcus aureus dan MRSA terhadap antibiotika spektrum luas mendorong berbagai penelitian untuk menemukan senyawa aktif yang sensitif dan efektif dalam menghambat pertumbuhan bakteri.Penelitian ini bertujuan untuk mengetahui efek penghambatan ekstrak daun putri malu (Mimosa pudica terhadap pertumbuhan bakteri Staphylococcus aureus dan MRSA.Penelitian terhadap aktivitas antimikrobial ekstrak daun putri malu dilakukan dengan metode agar difusi cakram dengan menggunakan metode Kirby-Bauer.Suspensi bakteri disesuaikan dengan standar kekeruhan Mc Farland 0.5. Biakan bakteri dalam cawan petri masing-masing diberikan 6 perlakuan, yaitu kontrol positif (amoxicillin atau vancomycin, kontrol negatif (alkohol, serta ekstrak daun putri malu dengan konsentrasi 25 mcg/ml, 50 mcg/ml, 75 mcg/ml dan 100 mcg/ml. Pertumbuhan Staphylococcus aureus dihambat secara signifikan oleh ekstrak daun putri malu, dengan efek inhibisi pada semua konsentrasi secara signifikan lebih baik dibandingkan dengan kontrol positif (p<0.05. Zona inhibisi Staphylococcus aureus pada konsentrasi 25 mcg/ml adalah 28.86 mm dan telah memenuhi kriteria sebagai antimikrobial sensitif berdasarkan Clinical and Laboratory Standard Institute (CLSI. Inhibisi pertumbuhan MRSA secara signifikan terjadi pada semua konsentrasi ekstrak daun putri malu dibandingkan dengan kontrol negatif (p=0.00. Zona inhibisi terbesar ditemukan pada konsentrasi 100 mcg/ml dengan diameter sebesar 14.16 mm dan memiliki efek antimikrobial sebanding dengan vancomycin dalam menghambat pertumbuhan MRSA (p=0.186. Hasil uji agar difusi cakram menunjukkan bahwa senyawa aktif dalam ekstrak daun putri malu memiliki aktivitas antimikrobial yang tinggi terhadap Staphylococcus aureus dan MRSA secara in vitro.

RANCANG BANGUN APLIKASI PENGAMBILAN BERITA SECARA OTOMATIS MENGGUNAKAN CONTENT SYNDICATION BERBASIS XML DENGAN PLATFORM MICROSOFT .NET

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Diana Purwitasari

2004-01-01

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Cable TV: Bringing Home Native Speaker to Increase Listening Comprehension of the Students of English Education Department Teacher Training and Education Faculty Muria Kudus University

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Rismiyanto Nuraeningsih

2016-07-01

Full Text Available This study investigated the use of cable TV to increase listening comprehension of the students of English education department of Muria Kudus University. The aims were to find out: (1 the listening comprehension achievement of the students taught by using cable TV, (2 the students’ response towards the teaching of listening comprehension class by using cable TV, and (3 the students’ difficulties when being involved in the listening class taught by using cable TV are. A classroom action research was conducted with three cycles. The data was collected by using test, observation checklist, & a questionnaire. The subject consisted of 29 students joining Advanced Listening class. The findings show that: (a The listening comprehension achievement of the students taught by using cable TV in cycle I, II, & III is fair, (b The students have enthusiasm and seriousness and motivation in joining the class in all cycles, (c In cycle III the students’ difficulties when being involved in the listening comprehension class taught by using cable TV are more and more decreasing. Keywords: Cable TV, Listening Comprehension

IMPLEMENTASI POPULATION RESIZING ON FITNESS IMPROVEMENT GENETIC ALGORITHM (PROFIGA UNTUK OPTIMASI RUTE KUNJUNGAN PROMOSI UNIVERSITAS MURIA KUDUS BERBASIS ANDROID DAN GOOGLE MAPS API

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Tri Listyorini

2016-04-01

Full Text Available Tim Promosi Universitas Muria Kudus (UMK melakukan kunjungan promosi ke sekolah menengah atas pada setiap tahun. Kunjungan tersebut dilakukan ke sekolah-sekolah menengah atas di wilayah Kudus, Jepara, Pati, Demak, Rembang dan Purwodadi. Untuk memudahkan kunjungan, setiap kunjungan dibatasi sekitar 15 (lima belas sekolah. Namun pada saat melakukan kunjungan, tim tersebut mengalami kesulitan dalam menentukan rute kunjungan sekolah. Hal ini dikarenakan jarak sekolah yang dikunjungi cukup jauh atau memiliki rute yang rumit sehingga menyebabkan waktu kunjungan yang molor dan biaya pengeluaran bahan bakar yang cukup boros. Untuk menyelesaikan masalah tersebut, dikembangkan suatu aplikasi menggunakan metode heuristik algoritma genetika dengan dinamisasi ukuran populasi atau Population Resizing on Fitness Improvement Genetic Algorithm (PRoFIGA. Aplikasi dikembangkan dengan basis android digunakan untuk memudahkan mencari rute kunjungan terpendek bagi tim promosi UMK sehingga waktu kunjungan menjadi efektif dan efisien. Hasil dari penelitian adalah aplikasi berbasis android untuk penentuan rute kunjungan sekolah terpendek menggunakan metode heuristik yang efisien dan efektif yang dikombinasikan dengan Google Maps Application Programming Interface (API untuk display rute kunjungan sehingga lebih memudahkan bagi tim promosi UMK. Kata kunci: optimasi rute kunjungan, algoritma fuzzy evolusi, optimasi rute android.

PERLINDUNGAN HUKUM TERHADAP ANAK YANG TEREKSPLOITASI SECARA EKONOMI DI KOTA PADANG

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Laurensius Arliman S

2016-04-01

Full Text Available Abstract This paper examines and analyzes the role and constraints of the Department of Social Welfare and Labor of Padang in carrying out child protection economically exploited. This paper uses socio legal research. The results of this paper are: Department of Social Welfare and Labor of Padang has been quite active in implementing the protection of children who are economically exploited, by conducting raids, coaching and training. The obstacles foundwere classic, namely: the nature of the child, the family, the fade of religious values, education, community, economic, cultural shift, the lack of facilities for the development of children, the lack of human resources, and inadequate funds. The author expects that in the future the child is considered by the government of Padang and also by the Child Family and Community. Key words: child, Department of Social Welfare and Labor, economics, padang, exploitation   Abstrak Tulisan ini meneliti serta menganalisis peran dan kendala-kendala Dinas Sosial dan Tenaga Kerja Kota Padang dalam menjalankan perlindungan anak yang dieksploitasi secara ekonomi. Tulisan ini menggunakan penelitian socio legal. Hasil dari tulisan ini adalah: Dinas Sosial dan Tenaga Kerja Kota Padang sudah cukup aktif dalam melaksanakan perlindungan anak yang dieksploitasi secara ekonomi, dengan mengadakan razia, pembinaan dan pelatihan. Kendala yang ditemukan, adalah kendala yang terbilang klasik yaitu: sifat dari anak, keluarga, nilai-nilai agama yang luntur, pendidikan, lingkungan masyarakat, masalah ekonomi, pergeseran budaya, fasilitas pembinaan anak yang kurang, sumber daya manusia yang kurang, dan dana yang kurang memadai. Penulis mengharapkan kedepannya, agar anak lebih diperhatikan oleh Pemerintah Kota Padang serta Masyarakat dan Keluarga anak. Kata kunci: anak, dinsosnaker, ekonomi, padang, eksploitasi

Konversi Rumput Laut Menjadi Monosakarida Secara Hidrotermal

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Silvy Eka Andansari

2014-09-01

Full Text Available Rumput laut merupakan salah satu sumber devisa negara dan sumber pendapatan bagi masyarakat pesisir dan merupakan salah satu komoditi laut yang sangat populer dalam perdagangan dunia, karena pemanfaatannya yang demikian luas dalam kehidupan sehari-hari, baik sebagai sumber pangan, obat-obatan dan bahan baku industri. Pada proses hidrolisis biasanya menggunakan katalisator asam seperti HCl, asam sulfat. Bahan yang digunakan untuk proses hidrolisis adalah pati. Hidrolisis merupakan reaksi pengikatan gugus hidroksil / OH oleh suatu senyawa. Tujuan penelitian ini antara lain mempelajari proses, pengaruh waktu, suhu, dan konsentrasi katalis terhadap reaksi konversi, serta kinetika reaksi proses hidrolisis rumput laut menjadi monosakarida secara hidrotermal. Dari hasil analisa penelitian yang telah dilakukan, didapatkan analisa gula pereduksi menggunakan metode HPLC dan spektofotometer reagen Nelson-Somogyi. Hidrolisis termal rumput laut dengan katalis asam sulfat dapat menghasilkan gula reduksi. Dari hasil penelitian dan analisa yang telah dilakukan, semakin lama waktu hidrolisis, semakin tinggi suhu, dan semakin besar konsentrasi katalis yang diberikan dapat menghasilkan % gula reduksi yang besar yaitu pada kondisi 80 menit; 240°C; 1N katalis menghasilkan presentase gula reduksi sebesar 0,2848 %. Dengan reaksi yang didapatkan adalah reaksi orde 1, diperoleh energi aktivasi yang lebih kecil pada konsentrasi katalis 1N yaitu sebesar 12.675 J/mol.

ANALISIS CFD HAMBATAN LAMBUNG KAPAL TRIMARAN ASIMETRIS FLAT SIDE INSIDE DENGAN VARIASI JARAK ANTAR LAMBUNG SECARA MEMBUJUR

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Andrew Gibson

2016-04-01

Full Text Available Kapal dibuat dengan fungsi sebagai sarana transportasi untuk kebutuhan niaga maupun perang. Saat ini kebutuhan kapal cepat meningkat sehingga diperlukan kapal dengan bentuk multihull, salah satunya adalah kapal Trimaran. Kapal Trimaran merupakan kapal yang mempunyai 3 lambung, yaitu satu mainhull dan dua side-hull atau disebut juga outriggers sehingga mempunyai nilai stabilitas yang tinggi. Untuk itu, perlu dilakukan penelitian lebih lanjut untuk membuat kapal Trimaran yang memiliki hambatan yang kecil sehingga dapat menambah nilai ekonomis dari segi efisiensi mesin dan performa kapal yang baik. Berbagai bentuk badan kapal kemudian dikembangkan untuk mendapatkan desain lambung kapal Trimaran yang paling optimum salah satunya adalah kapal Trimaran flat side inside, yaitu sebuah konfigurasi baru dengan lambung yang memiliki bidang datar atau asimetris di dalam. Penelitian ini bertujuan untuk mendapatkan variasi letak stagger atau jarak antar lambung secara membujur (R/L kapal Trimaran asimetris flat side inside yang menghasilkan hambatan paling kecil dengan menggunakan bantuan software Computational Fluid Dynamics (CFD. Dengan melakukan variasi kecepatan yaitu 12, 14, 16, dan 22 knot dan variasi jarak antar lambung (R/L dimana R merupakan jarak antar lambung secara membujur dan L adalah panjang kapal mainhull, yaitu untuk R/L = 0.1, R/L = 0.2 dan R/L = 0.3  pada ketentuan jarak antar lambung secara melintang (S/L = 0.4 dapat dilihat pengaruh interaksi gelombang terhadap nilai hambatan gelombang kapal Trimaran asimetris flat side inside. Hasil pengujian didapatkan bahwa  model C dengan R/L = 0,3 dan S/L = 0,4 adalah variasi model paling baik dalam tugas akhir ini karena menghasilkan hambatan viscous dan hambatan total        terkecil dengan presentase yang dibandingkan dengan model awal masing-masing 7,137 % dan 24,965 %.

Efek Antibakteri Ekstrak Daun Mimba (Azadirachta indica A. Juss) terhadap Bakteri Vibrio algynoliticus Secara In Vitro

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Uli Ayini; Siti Harnina B.; Titis Candra Dewi

2014-01-01

Budidaya udang windu di Indonesia telah berkembang pesat. Salah satu kendala budidaya udang adalah penyakit Vibriosis yang disebabkan oleh bakteri Vibrio algynoliticus. Tujuan penelitian ini adalah untuk mengetahui efek antibakeri ekstrak daun mimba terhadap bakteri Vibrio algynoliticus. Penelitian ini menggunakan metode dilusi untuk mengetahui efek antibakteri ekstrak daun mimba terhadap bakteri Vibrio algynoliticus secara in vitro. Konsentrasi ekstrak yang digunakan (%) yaitu: 0; 2,5; 5; 7,...

PENGGUNAAN AUGMENTED REALITY UNTUK MENSIMULASIKAN DEKORASI RUANGAN SECARA REAL TIME

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Ulva Erida Nur Rochmah

2016-12-01

Full Text Available Abstrak Mendekorasi ruangan merupakan kegiatan  yang memakan banyak waktu dan tenaga, terutama jika objek yang digunakan besar dan berat. Akan merepotkan jika seseorang harus menggeser setiap objek untuk menentukan letak yang sesuai. Hal ini dapat dihindari dengan menggunakan aplikasi berbasis Augmented Reality. Augmented Reality merupakan sebuah teknologi untuk menggabungkan dunia nyata dan dunia virtual dengan cara menampilkan objek-objek virtual di dunia nyata secara real time. Tujuan utama dari penelitian ini adalah untuk menciptakan suatu aplikasi Android dengan menggunakan Augmented Reality yang dapat digunakan untuk menggantikan objek nyata dengan objek virtual 3D sehingga memudahkan pengguna dalam mensimulasikan dekorasi ruangan. Aplikasi ini bekerja dengan cara memindai marker yang sudah dicetak pada selembar kertas. Jika marker telah terdeteksi, objek 3D berupa perabot akan ditampilkan di kamera aplikasi. Pengguna dapat memindah lokasi, memutar, dan mengubah ukuran objek untuk mensimulasikan tata letak ruangan. Hasil penelitian ini adalah aplikasi Android berbasis Augmented Reality yang dapat digunakan untuk mensimulasikan dekorasi ruangan secara real time. Kata Kunci: augmented reality, dekorasi, interior, marker Abstract Decorating the room is an activity that takes a lot of time and effort, especially if the object is large and heavy. It would be inconvenient if someone has to drag each object to determine the appropriate location. This problem can be avoided using an Augmented Reality-based application. Augmented reality is a technology that combine the real world and the virtual world by displaying virtual object in real world. The main purpose of this research is to create an Android application using Augmented reality  that can be used to replace the real object with virtual 3D object, making it easier for the user to simulate the decoration of the room. This application works by scanning the marker that has been printed on a

PENGUNGKAPAN KEUANGAN PERKARA SECARA MEMADAI DALAM LAPORAN KEUANGAN SATUAN KERJA PERADILAN

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Muhammad Anis

2013-07-01

Full Text Available Biaya perkara yang dipungut dan dikelola pada Mahkamah Agung dan lembaga peradilan dibawahnya sampai dengan saat ini masih menjadi persoalan terkait transparansi dan akuntabilitas pengelolaan dan penatausahaannya. Berdasarkan Surat Edaran Mahkamah Agung Nomor 09 Tahun 2008 tentang Pelaporan Penerimaan dan Penggunaan Biaya Perkara pada Pengadilan dan Peraturan Mahkamah Agung RI. No. 03 Tahun 2012 tentang Biaya Proses penyelesaian perkara dan Pengelolaannya pada MA dan Badan Peradilan yang berada dibawahnya telah diatur bahwa Biaya Perkara pada pengadilan dalam bentuk agregatditampilkan ke muka publik secara berkala dan dikelola secara efektif, efisien, transparan dan dicatat dalam Catatan atas Laporan Keuangan Mahkamah Agung RI. Berdasarkan Surat Edaran Ketua Mahkamah Agung Nomor 09 Tahun 2008, pelaporan biaya perkara telah berjalan namun belum ditampilkan dalam Laporan keuangan lembaga. Biaya perkara merupakan bagian dari informasi penting yang harus dilaporkan dalam laporan keuangan lembaga sebagai bentuk akuntabilitas lembaga atas biaya yang dipungut dan atau diterima dari pihak ke tiga. Legal fees are collected and maintained by Supreme Court and the courts underneath it so far still an issue related to the management of accounting and reporting. Based on Surat Edaran Mahkamah Agung Nomor 09 tahun 2008 tentang Pelaporan Penerimaan dan Penggunaan Biaya Perkara pada Pengadilan and Peraturan Mahkamah Agung RI. No. 03 Tahun 2012 tentang Biaya Proses penyelesaian perkara dan Pengelolaannya pada MA dan Badan Peradilan yang berada dibawahnyaIn these rules have arranged that legal fees in the court aggregately were published periodically and managed effectively, efficiently, transparency and stored in a note upon the financial report of the supreme court. Based on Surat Edaran Mahkamah Agung Nomor 09 tahun 2008, report of legal fees has been running well but not yet shown in the financial statements of the institution. The legal fees become important

Sleep apnea and REM sleep behavior disorder in patients with Chiari malformations Apnéia do sono e distúrbio do comportamento da fase do sono com REM em pacientes com malformações de Chiari

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Paulo Sérgio A. Henriques-Filho

2008-06-01

Full Text Available BACKGROUND: Chiari malformations (CM may result in the appearance of REM sleep behavior disorder (RBD and sleep apnea syndrome (SAS that can be considered markers of brain stem dysfunction. PURPOSE: To evaluate the frequency of RBD and SAS in patients with CM type I and II. METHOD: Were evaluated 103 patients with CM by means of full night polysomnography. Were scoring different sleep stages, frequency of abnormal movements (through video monitoring and abnormal respiratory events. RESULTS: Of the 103 patients, 36 showed CM type I and 67 CM type II. Episodes of RBD were observed in 23 patients. Abnormal apnea-hypopnea index (AHI was observed in 65 patients. CONCLUSION: The high rate of RBD suggests that this parassomnia and the increased frequency of central sleep apnea episodes, may be considered as a marker of progressive brain stem dysfunction.INTRODUÇÃO: Malformações de Chiari (MC podem gerar o aparecimento de distúrbio comportamental da fase do sono com REM (DCR e síndrome da apnéia do sono (SAS, sugerindo a ocorrência de disfunção do tronco cerebral. OBJETIVO: Avaliar a freqüência de DCR e SAS em pacientes com MC I ou II. MÉTODO: Utilizou-se a polissonografia de noite inteira para a avaliação de 103 pacientes. Classificaram-se as diferentes fases do sono e analisou-se a freqüência de movimentos anormais (monitorada por vídeo e de eventos respiratórios anormais. RESULTADOS: Dos 103 pacientes analisados, 36 eram portadores de MC I e 67 de MC II. Episódios de DCR foram observados em 23 pacientes. O índice de apnéia/hipopnéia foi considerado anormal em 65 pacientes. CONCLUSÃO: A alta freqüência de DCR e o aumento da freqüência de episódios de apnéia central do sono podem ser considerados manifestação de disfunção progressiva do tronco cerebral.

Mediasi perbankan dalam kerangka penyelesaian sengketa perbankan secara sederhana, Cepat, dan biaya ringan

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noor hafidah

2017-01-01

Full Text Available Industri perbankan sebagai bagian dari Industri keuangan mempunyai karakteristik yang khusus sebagai lembaga keuangan. Karakteristik khusus tersebut tercermin dalam operasional perbankan yang memiliki fungsi Intermediary, yaitu menghimpun dan menyalurkan dana kepada masyarakat yang dilandasi oleh kepercayaan, serta layanan yang lebih kompleks yang meliputi pembiayaan makro, pembiayaan ekspor impor, transaksi derivatif, fasilitas pembayaran perdagangan internasional (letter of credit dan lain sebagainya.Layanan Perbankan yang sedemikian kompleks dalam prakteknya kadang kala bersentuhan dengan konflik atau sengketa. Sengketa dapat terjadi karena adanya perbedaan pendapat antara bank dengan nasabah mengenai kewajiban dan hak masing-masing, wanprestasi dari nasabah sebagai debitur, tindakan sepihak bank yang dianggap merugikan nasabah, dan sebagainya. Kenyataan demikian menuntut adanya pola penyelesaian sengketa yang efektif dan efisien.Dalam konteks penyelesaian sengketa secara demikian, Bank Indonesia sebagai bank sentral yang memiliki kewenangan dalam menata aktivitas perbankan di Indonesia telah mengeluarkan beberapa peraturan yang terkait dengan mekanisme penyelesaian sengketa, antara lain Peraturan Bank Indonesia Nomor 8/5/PBI/2006 tanggal 30 Januari 2006 dan Surat Edaran Bank Indonesia Nomor 8/14/DPNP tanggal 1 Juni 2006 tentang Mediasi Perbankan.Pasal 1 angka 5 Peraturan Bank Indonesia Nomor 8/5/PBI/2006 menyatakan bahwa mediasi merupakan proses penyelesaian sengketa yang melibatkan mediator untuk membantu para pihak yang bersengketa guna mencapai penyelesaian dalam bentuk kesepakatan sukarela terhadap sebagian ataupun seluruh permasalahan yang disengketakanModel penyelesaian mediasi bagi kalangan perbankan merupakan model yang dianggap tepat karena hubungan bank dan nasabah mengandung kerahasiaan. Kerahasiaan dimaksud adalah kerahasiaan bank sebagaimana tersebut di dalam pasal 40 UU No. 10 tahun 1998 tentang Perbankan. Penyelesaian secara

Atualização em síndrome da apnéia obstrutiva do sono na infância Update in obstructive sleep apnea syndrome in children

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Aracy P. S. Balbani

2005-02-01

Full Text Available A prevalência de SAOS em crianças é de 0,7-3%, com pico de incidência nos pré-escolares. Fatores anatômicos (obstrução nasal severa, más-formações craniofaciais, hipertrofia do tecido linfático da faringe, anomalias laríngeas, etc. e funcionais (doenças neuromusculares predispõem à SAOS na infância. A principal causa da SAOS em crianças é a hipertrofia adenotonsilar. As manifestações clínicas mais comuns são: ronco noturno, pausas respiratórias, sono agitado e respiração bucal. A oximetria de pulso noturna, a gravação em áudio ou vídeo dos ruídos respiratórios noturnos e a polissonografia breve diurna são métodos úteis para triagem dos casos suspeitos de SAOS em crianças, e o padrão-ouro para diagnóstico é a polissonografia em laboratório de sono durante uma noite inteira. Ao contrário dos adultos com SAOS, as crianças costumam apresentar: menos despertares associados aos eventos de apnéia, maior número de apnéias/hipopnéias durante o sono REM e dessaturação mais acentuada da oxihemoglobina mesmo nas apnéias de curta duração. O tratamento da SAOS pode ser cirúrgico (adenotonsilectomia, correção de anomalias craniofaciais, traqueostomia ou clínico (higiene do sono, pressão positiva contínua nas vias aéreas - CPAP.The prevalence of OSAS in children is 0.7-3%, with peak incidence in pre-schoolers. It is characterised by partial or complete upper airway obstruction during sleep, causing intermittent hypoxia. Both anatomical (severe nasal obstruction, craniofacial anomalies, hypertrophy of the pharyngeal lymphoid tissue, laryngeal anomalies, etc. and functional factors (neuromuscular diseases predispose to OSAS during childhood. The main cause of OSAS in children in adenotonsillar hypertrophy. The most common clinical manifestations of OSAS are: nocturnal snoring, respiratory pauses, restless sleep and mouth breathing. Nocturnal pulse oximetry, nocturnal noise audio/videotape recording and nap

PEMBUATAN ALAT LABORATORIUM FISIKA FAKULTAS ILMU TARBIYAH DAN KEGURUAN IAIN WALISONGO UNTUK PRAKTIKUM OSILASI CAIRAN DAN AYUNAN MATEMATIS SECARA DIGITAL

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agus sudarmanto

2016-02-01

Hasil penelitian ini adalah bahwa pembuatan alat lab- oratorium sika  untuk praktikum osilasi cairan dan ayu- nan matematis secara digital sudah dapat berfungsi sesuai dengan yang diinginkan dan data hasil dari alat tersebut mendekati nilai percepatan gravitasi bumi sebenarnya yai- tu sebesar 9,8 m/s2.

Perawatan Pulpektomi Secara Singkat Pada Gigi Sulung Nekrotik (Laporan Kasus

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Sarworini Bagio Budiardjo

2015-10-01

Full Text Available Perawatan pulpektomi gigi sulung nekrotik akibat atrisi, trauma atau karies yakni pembuangan seluruh jaringan pulpa nekrotik dan menggantikannya dengan bahan pengisi yang padat, dapat diresorbsi serta tampak secara radiografis. Tujuannya antara lain untuk mempertahankan gigi sulung sampai saatnya digantikan dengan gigi tetap pengganti. Perkembangan, anatomi dan histologi gigi sulung membedakan teknik perawatan pulpektomi gigi sulung dan gigi tetap.Indikasinya adalah gigi sulung nekrotik tanpa peradangan periapikal, mahkota mendukung sterilisasi dan dapat direstorasi serta resorbsi akar fisiologis kurang dari sepertiga akar.Kesulitan perawatan terutama karena bentuk saluran akar yang sangat bervariasi dan resorbsi akar yang tidak beraturan. Tahap perawatan terdiri dari persiapan gigi, sterilisasi, pengisian dan restorasi.Keempat tahap dapat diselesaikan dalam satu kali kunjungan.Pada keadaan dimana terjadi kesulitan persiapan gigi, maka tindakan pengisian saluran akar dan restorasi ditunda 1 minggu kemudian, sehingga perawatan pulpektomi diselesaikan dalam 2 kali kunjungan.Dalam laporan kasus, perawatan pulpektomi dilakukan pada gigi insisif dan molar sulung dengan teknik 1-2 kali kunjungan.Sebagai bahan sterilisasi saluran akar digunakan formokresol dan bahan pengisi campuran zinkoksid-eugenol.  

UJI AKTIVITAS EKSTRAK DAUN SIRIH (Piper betle L.) SECARA IN VIVO TERHADAP SCABIES PADA KAMBING KACANG (Capra hircus)

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-, NUR SRIANI REZKI

2017-01-01

ABSTRAK Nur Sriani Rezki. O111 12 110, Uji Aktivitas Ekstrak Daun Sirih (Piper betle L.) Secara In Vivo terhadap Scabies pada Kambing Kacang (Capra hircus). Di bawah bimbingan ABDUL WAHID JAMALUDDIN dan MUHAMMAD FADHLULLAH MURSALIM. Kehidupan ternak kambing sering diganggu oleh beberapa penyakit. Salah satu yang disebabkan oleh parasit terutama ektoparasit yang sering dijumpai adalah scabies. Penyakit ini umumnya disebabkan oleh Sarcoptes scabiei. Tujuan penelitian ini untuk menguji akt...

Síndrome da apnéia-hipopnéia obstrutiva do sono. Fisiopatologia Physiopathology of obstructive sleep apnea-hypopnea syndrome

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Andrea Barral Martins

2007-02-01

Full Text Available A fisiopatogenia da apnéia obstrutiva do sono é multifatorial. O sexo, a obesidade, os fatores genéticos, anatômicos e hormonais e o controle da ventilação interagem diversamente na fisiopatogenia e expressão clínica da doença. A obesidade é o principal fator de risco, sendo a elevação do índice de massa corpórea, da gordura visceral e da circunferência do pescoço, fortes preditores de sua ocorrência. A progesterona, por aumentar a atividade dos músculos dilatadores das vias aéreas superiores, tem papel protetor nas mulheres antes da menopausa, justificando a maior prevalência da doença na pós-menopausa, no sexo masculino e na síndrome dos ovários policísticos. Evidências apontam para o fato de que o aumento da idade promove diminuição do tônus muscular, com redução da luz das vias aéreas superiores. O dismorfismo crânio-facial, como na retrognatia ou micrognatia, está associado ao posicionamento posterior da língua, e pode resultar em estreitamento da luz das vias aéreas superiores. Finalmente, comando ventilatório reduzido tem sido detectado em pacientes com síndrome de apnéia obstrutiva do sono e hipercapnia.The physiopathology of obstructive sleep apnea syndrome is multifactorial. Gender and obesity status, as well as genetic, anatomic, and hormonal factors, together with ventilatory drive, interact in a diverse manner in the physiopathology and clinical expression of the disease. Obesity is the main risk factor, since increases in body mass index, visceral fat, and neck circumference are strong predictors of the disease. Progesterone increases the activity of the upper airway dilator muscles and therefore plays a protective role in premenopausal women. This explains the fact that the prevalence of the disease is higher in postmenopausal patients, in patients with polycystic ovary syndrome, as well as in males. Evidence supports the fact that, as individuals grow older, there is a decrease in muscle

Karakterisasi Unjuk Kerja Diesel Engine Generator Set Sistem Dual Fuel Solar-Syngas Hasil Gasifikasi Briket Municipal Solid Waste (MSW Secara Langsung

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Achmad Rizkal

2017-01-01

Full Text Available Sejalan dengan semakin banyaknya kebutuhan energi untuk dapat digunakan sebagai bahan bakar maka perlu adanya pengembangan gas biomassa sebagai bahan bakar alternatif pada motor pembakaran dalam maka akan dilakukan penelitian mengenai aplikasi sistem dual fuel gas hasil gasifikasi biomassa municipal solid waste (msw pada sistem downdraft dengan minyak solar pada motor diesel stasioner. Penelitian ini bertujuan untuk mengetahui seberapa besar solar yang tersibtitusi dengan adanya penambahan syngas yang disalurkan secara langsung. Penelitian ini dilakukan secara eksperimental dengan proses pemasukan aliran syngas yang dihasilkan downdraft municipal solid waste (MSW kedalam saluran udara mesin diesel generator set secara langsung menggunakan sistem mixer. Pengujian dilakukan dengan putaran konstan 2000 rpm dengan pembebanan bervariasi dari 200 watt sampai dengan 2000 watt dengan interval 200 watt. Bahwa produksi syngas dari reaktor gasifikasi ditambahkan sistem bypass untuk mengetahui kesesuaian antara reaktor gasifikasi dan mesin generatorset data ṁ syngas yang dibutuhkan mesin diesel, ṁ syngas yang di bypass untuk mendapatkan kesesuaian antara produksi syngas dan yang di bypass.  Data-data yang diukur dari penelitian ini menunjukkan bahwa besar nilai mass flowrate gas syngas yang dibutuhkan mesin diesel pada AFR reaktor gasifier 1,39 sebesar 0,0003748 kg/s. Mass flowrate gas syngas yang di bypass menunjukkan nilai 0 pada saat sistem dijalankan karena seluruh gas syngas masuk kedalam ruang bakar. AFR rata-rata sebesar 14,54 ,Nilai Spesifik fuel consumption (sfc mengalami peningkatan 68% dari kondisi standar single fuel , Nilai efesiensi thermal mengalami kenaikan sebesar 7% dari kondisi single fuel, Nilai daya rata-rata sebesar 2,28kW, Nilai torsi rata-rata sebesar 10,94 N.m. Solar yang tersibtitusi sebesar 48%. Nilai temperatur (coolant, mesin, oil, dan gas buang pada setiap pembebanan mengalami kenaikan.

Ronco habitual e apnéia obstrutiva observada em adultos: estudo de base populacional, Pelotas, RS Habitual snoring and obstructive sleep apnea in adults: population-based study in Southern Brazil

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Ricardo B Noal

2008-04-01

Full Text Available OBJETIVO: Estimar a prevalência de ronco habitual e apnéia obstrutiva observada e fatores associados. MÉTODOS: Estudo transversal com amostra representativa de 3.136 adultos, com 20 anos ou mais, residentes em Pelotas, Rio Grande do Sul, em 2005. Informações sobre os desfechos e variáveis demográficas, socioeconômicas, comportamentais e antropométricas foram coletadas por meio de questionário. A análise estatística bruta e ajustada foi realizada utilizando-se teste exato de Fisher ou qui-quadrado de tendência linear e regressão de Poisson, respectivamente. RESULTADOS: A prevalência encontrada de ronco habitual foi de 50,5% (IC 95%: 48,1;52,8 e de apnéia obstrutiva de 9,9% (IC 95%: 8,7;11,2. Na análise ajustada, o relato de ronco foi maior nos homens (Razão de Prevalências - RP=1,25; IC 95%: 1,16;1,34, nos idosos (RP=1,62; IC 95%: 1,46;1,80, nos tabagistas (RP=1,15; IC 95%: 1,07;1,25, nos alcoolistas (RP=1,17; IC 95%: 1,03;1,31 e nos obesos (RP 1,71, IC95% 1,55;1,88. O relato de apnéia obstrutiva foi maior nos homens (RP=2,05; IC 95%: 1,67;2,52, nos idosos (RP=2,23; IC 95%: 1,64;3,03, nos tabagistas (RP=1,60; IC 95%: 1,25;2,05 e nos obesos (RP=2,61; IC 95%: 1,97;3,47. CONCLUSÕES: Ronco habitual e apnéia obstrutiva foram sintomas comuns na população estudada. Fatores de risco conhecidos como sexo masculino e idade entre quarta e quinta décadas de vida não são modificáveis. Entretanto, tabagismo, alcoolismo e obesidade também associados aos desfechos, devem ser identificados e tratados na população geral.OBJECTIVE: To estimate the prevalence of habitual snoring and obstructive sleep apnea and their factors associated. METHODS: Cross-sectional study with a representative sample comprising 3,136 adults (>20 years living in the city of Pelotas, Southern Brazil, in 2005. A questionnaire was used to collect information on demographic, socioeconomic, behavioral and anthropometric variables and outcomes. Crude and adjusted

Pembuatan Biodiesel Dari Minyak Kelapa Dengan Katalis NaOH Menggunakan Gelombang Mikro (Microwave Secara Kontinyu

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Daru Satria Prayanto

2016-04-01

Full Text Available Biodiesel merupakan bioenergi atau bahan bakar nabati yang dibuat dari minyak nabati melalui proses transesterifikasi, esterifikasi, atau proses esterifikasi-transesterifikasi. Proses pembuatan biodiesel dapat dilakukan dengan metode pemanasan konvensional maupun dengan metode pemanasan microwave. Dengan radiasi microwave, maka waktu yang dibutuhkan saat proses transesterifikasi lebih singkat dibandingkan dengan konvensional. Disisi lain, minyak kelapa memiliki potensi yang besar untuk digunakan sebagai bahan baku dalam pembuatan biodiesel karena ketersediaannya yang melimpah. Penelitian ini bertujuan untuk membuat biodiesel dari minyak kelapa secara kontinyu melalui proses transesterifikasi metanol dengan menggunakan radiasi microwave dengan katalis NaOH dan mempelajari pengaruh konsentrasi tiap katalis, daya, dan laju umpan yang digunakan terhadap yield, densitas, dan viskositas biodiesel yang dihasilkan. Dalam penelitian ini di gunakan 3 variabel, yaitu laju umpan 0,73; 1,25; 1,72 ml/s, konsentrasi katalis 0,25; 0,5; 1 (% berat variabel daya microwave 100, 264, 400, 600, dan 800 Watt. Rasio umpan ditentukan pada 1:9. Pada tahap persiapan melarutkan metanol dan katalis sesuai dengan variabel hingga tercampur homogen. Selanjutnya tahap transesterifikasi dengan mencampurkan larutan metanol (metanol dan katalis dengan minyak kelapa dengan mol ratio yang telah ditentukan dan mengatur daya microwave untuk memulai proses transesterifikasi, proses berlangsung secara kontinyu menggunakan mix flow reaktor. Selanjutnya pemisahan hasil transesterifikasi dari gliserol, dilanjutkan dengan tahap pencucian dengan aquadest untuk memisahkan impurities dan katalis yang masih tersisa dalam biodiesel kemudian memanaskan pada oven untuk menguapkan kandungan air dalam biodiesel. Selajutnya menganalisisa hasil biodiesel terhadap yield, densitas, dan viskositasnya. Hasil terbaik dari variabel yang digunakan di atas adalah pada katalis NaOH dengan konsentrasi 1

KEPASTIAN HUKUM DALAM PELELANGAN OBJEK HAK TANGGUNGAN SECARA ONLINE

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Begiyama Fahmi Zaki

2017-03-01

Full Text Available Abstract an auction object the formal use of mortgage online in KPKNL arranged in Article 54 paragraph (3 Minister of Finance Regulation Number 106/PMK.06/2013 that the supply of indirect in writing can be done via email or the internet. The auction the object a mortgage via email done through the application of auction email (ALE, both in terms of registration prospective bidders and documents should be equipped with the determination of the winning bidder performed on these applications. Legal certainty in this case that is at the time of the registration process bidders up to set the winning bidder through ALE. This strengthens with the Law Number 11 of 2008 on information and electronic transaction, where Article 5 paragraph (1 described that information electronically and/or document electronic and/or result print is a legal evidence legitimate. The principle of legal certainty of the opinion that an auction had been conducted by KPKNL for the legal protection to parties concerned to an auction. This is in accordance with rights legislation are explained that when debtors injured promise, the holder the mortgage over its own power has the right to sell by auction common. Implementing auction made treatise auction by officials an auction is a certificate authentic in accordance with Article 1867 and 1868 the book the Act of Civil Law. Treatise auction used the seller/the owner goods, buyers and officials auction to maintain and carry out their rights and duties and have the power of perfect in accordance with Article 1 the 32 Minister of Finance Regulation Number 106/PMK.06/2013. Key words: Legal Certainty, The Protection of the Law, Auction, Mortgage Object, Online Volume Abstrak Penggunaan resmi obyek lelang hipotek secara online di KPKNL diatur dalam Pasal 54 ayat (3 Peraturan Menteri Keuangan Nomor 106/PMK.06/2013 yang pasokan tidak langsung secara tertulis dapat dilakukan melalui email atau internet. Lelang objek hipotek melalui email

Neurocristopatia no diagnóstico diferencial das apnéias do recém nascido: relato de caso Neurochristopathy in the differential diagnosis of newborn's apnea: case report

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Magda Lahorgue Nunes

2001-12-01

Full Text Available OBJETIVO: incluir a neurocristopatia na investigação etiológica das apnéias refratárias do recém nascido e discutir o valor diagnóstico da polissonografia. MÉTODO: relato de caso e discussão crítica da literatura. RESULTADOS: relatamos o caso de um recém-nascido que apresentou disfunção ventilatória nas primeiras horas de vida associada a distensão abdominal, necessitando de ventilação mecânica contínua com piora do quadro respiratório durante o sono. Após o diagnóstico polissonográfico de hipoventilação foi investigado com exames de neuroimagem e biópsia de cólon, positiva para doença de Hirschprung. CONCLUSÃO: a neurocristopatia é uma síndrome neonatal que por vezes pode ter o seu reconhecimento dificultado pelo amplo espectro clínico associado. A polissonografia foi fundamental nesta investigação confirmando a hipoventilação. Este diagnóstico etiológico deve ser considerado na investigação de recém-nascidos com apnéias persistentes durante o sono.OBJECTIVE: to include neurocristopathy on the etiological workup of neonatal apneas and discuss the importance of polysomnography in this diagnosis. METHOD: case report and critical review of the literature. Results: we report on a newborn that presented respiratory failure in the first hours of life associated to abdominal distention. Continuous ventilatory support was necessary, and the respiratory distress increased during sleep. After polysomnographic confirmation of hypoventilation the newborn was submitted to neuroradiolgic tests and colon byopsy, positive to Hirschsprung's disease. CONCLUSION: Neurocristopathy syndrome can have many different clinical expression, and sometimes the syndrome can be misdiagnosed. Polysomnography confirms central hypoventilation. This diagnosis should be considered in the newborn's persistent apnea workup.

PEMBAGIAN TUGAS DALAM KOLONI ROBOT OTONOM BERGERAK PADA STUDI KASUS PEMBENTUKAN POLA FORMASI SECARA GRADUAL

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Wisnu Jatmiko

2012-05-01

Full Text Available Pada penelitian ini dilakukan suatu eksperimen pembentukan formasi pola dengan menggunakan Robot LEGO Mindstorms NXT. Pembentukan pola ini dilakukan secara bertahap dimulai dari pembentukan formasi pola yang lebih sederhana menuju kepada formasi pola yang lebih kompleks. Dalam penelitian ini, diterapkan konsep pembedaan peranan dalam pembentukan formasi pola poligon. Konsep pembedaan peranan ini diterapkan dengan menggunakan persamaan periodik. Selain itu, persamaan pembedaan peranan dibuat dengan fitur terbebas dari kondisi awal dari nilai variabel pembeda. Pembentukan formasi pola pada penelitian ini dilakukan dalam 3 tahapan, yaitu tahap penerapan persamaan, tahap penerapan robot simulasi, dan tahap penerapan perangkat robot. Pembentukan formasi pola yang dilakukan pada penelitian ini ada tiga macam, yaitu pembentukan formasi pola segitiga, pembentukan formasi pola segiempat / jajaran genjang, dan pembentukan formasi pola segilima.

A technical and economic evaluation of reverse osmosis nuclear desalination as applied at the Muria site in Indonesia

International Nuclear Information System (INIS)

Humphries, J.R.; Davies, K.; Vu, T.D.; Aryono, N.A.; Peryoga, Y.

1998-01-01

effects on the other. In co-operation with BPPT of Indonesia, CANDESAL and AECL have performed an evaluation of this nuclear desalination concept to establish the design, performance and economic characteristics of a large scale reverse osmosis seawater desalination plant coupled with a CANDU reactor, operating under conditions appropriate to the Muria site in Indonesia. The results of the evaluation are discussed herein. (author)

Bacillus thuringiensis Cry1Ca-resistant Spodoptera exigua lacks expression of one of four Aminopeptidase N genes

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Moar William J

2005-06-01

Full Text Available Abstract Background Insecticidal toxins from Bacillus thuringiensis bind to receptors on midgut epithelial cells of susceptible insect larvae. Aminopeptidases N (APNs from several insect species have been shown to be putative receptors for these toxins. Here we report the cloning and expression analysis of four APN cDNAs from Spodoptera exigua. Results Suppression Subtractive Hybridization (SSH was used to construct cDNA libraries of genes that are up-and down-regulated in the midgut of last instar larvae of beet armyworm, S. exigua exposed to B. thuringiensis Cry1Ca toxin. Among the clones from the SSH libraries, cDNA fragments coding for two different APNs were obtained (APN2 and APN4. A similar procedure was employed to compare mRNA differences between susceptible and Cry1Ca resistant S. exigua. Among the clones from this last comparison, cDNA fragments belonging to a third APN (APN1 were detected. Using sequences obtained from the three APN cDNA fragments and degenerate primers for a fourth APN (APN3, the full length sequences of four S. exigua APN cDNAs were obtained. Northern blot analysis of expression of the four APNs showed complete absence of APN1 expression in the resistant insects, while the other three APNs showed similar expression levels in the resistant and susceptible insects. Conclusion We have cloned and characterized four different midgut APN cDNAs from S. exigua. Expression analysis revealed the lack of expression of one of these APNs in the larvae of a Cry1Ca-resistant colony. Combined with previous evidence that shows the importance of APN in the mode of action of B. thuringiensis toxins, these results suggest that the lack of APN1 expression plays a role in the resistance to Cry1Ca in this S. exigua colony.

Cystatin C–Adiponectin Complex in Plasma Associates with Coronary Plaque Instability

Science.gov (United States)

Matsuoka, Tetsuro; Kayama, Kento; Onishi, Sumire; Matsuo, Natsumi

2017-01-01

Aim: Adiponectin (APN) is an adipocyte-derived bioactive molecule with antiatherogenic properties. We previously reported that cystatin C (CysC) abolished the anti-atherogenic effects of APN. We aimed to elucidate the clinical significance of CysC–APN complex in patients with coronary artery disease (CAD). Methods: We enrolled 43 stable CAD male patients to examine the relationship between CysC–APN complex and coronary plaque characteristics. Serum was immunoprecipitated by the anti-APN antibody and immunoblotted by the anti-CysC antibody to demonstrate the presence of CysC–APN complexes in vivo. To confirm their binding in vitro, HEK293T cell lysates overexpressing myc-APN and FLAG-CysC were immunoprecipitated with an anti-myc or anti-FLAG antibody, followed by immunoblotting with an anti-APN or anti-CysC antibody. Results: CysC was identified as a specific co-immunoprecipitant with APN by the anti-APN antibody in human serum. In vitro, FLAG-CysC was co-immunoprecipitated with myc-APN by the antimyc antibody and myc-APN was co-immunoprecipitated with FLAG-CysC by the anti-FLAG antibody. Among CAD patients, serum CysC–APN complex levels negatively correlated with fibrotic components of coronary plaques and positively correlated with either necrotic or lipidic plus necrotic components. Plaque burden negatively correlated with serum APN levels but not serum CysC–APN complex levels. Serum CysC levels had no association with plaque characteristics. In multivariate analysis, CysC–APN complex levels were identified as the strongest negative factor for fibrotic components and the strongest positive factor for both necrotic and lipidic plus necrotic components. Conclusion: Measuring serum CysC–APN complex levels is helpful for evaluating coronary plaque instability in CAD patients. PMID:28321013

Sintomas da síndrome de apnéia-hipopnéia obstrutiva do sono em crianças Symptoms of obstructive sleep apnea-hypopnea syndrome in children

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Paloma Baiardi Gregório

2008-06-01

Full Text Available OBJETIVOS: Investigar os sintomas mais freqüentes encontrados em crianças com diagnóstico polissonográfico de síndrome da apnéia-hipopnéia obstrutiva do sono (SAHOS. MÉTODOS: Foram avaliadas 38 crianças consecutivamente encaminhadas ao laboratório do sono com suspeita de SAHOS no período de junho de 2003 a dezembro de 2004. Os pacientes foram submetidos a um questionário pré-sono e a polissonografia. RESULTADOS: A idade média foi de 7,8 ± 4 anos (variação, 2-15 anos, sendo 50% das crianças do sexo masculino. Não apnéicos corresponderam a 7,9% dos pesquisados, distúrbio leve obstrutivo do sono ocorreu em 42,1%, moderado em 28,9% e severo em 22,1%. Observou-se maior freqüência de casos severos de apnéia entre crianças menores de seis anos (idade pré-escolar. Dentre as crianças com SAHOS, os sintomas mais citados foram ronco e obstrução nasal, presentes em 74,3 e 72,7% das crianças, respectivamente. Sonolência excessiva e bruxismo ocorreram em, respectivamente, 29,4 e 34,3% dos casos e doença do refluxo em apenas 3,1%. Agitação das pernas e dificuldade para iniciar o sono foram encontradas em, respectivamente, 65 e 33% dos avaliados. Todas as crianças que apresentaram SAHOS de grau severo tinham queixa de ronco e bruxismo. CONCLUSÕES: Nossos resultados mostraram que os sintomas mais freqüentes em crianças e adolescentes com SAHOS são ronco e obstrução nasal. Além disso, quadros mais graves da SAHOS estão associados à menor faixa etária.OBJECTIVE: To investigate the symptoms most frequently found in children with a polysomnographic diagnosis of obstructive sleep apnea-hypopnea syndrome (OSAHS. METHODS: We evaluated 38 children consecutively referred to the sleep laboratory with suspicion of OSAHS between June of 2003 and December of 2004. The patients were submitted to a pre-sleep questionnaire and to polysomnography. RESULTS: The mean age was 7.8 ± 4 years (range, 2-15 years, and 50% of the children

IMPLEMENTASI ALGORITMA MONTE CARLO PADA SISTEM INFORMASI PENERIMAAN PESERTA DIDIK BARU (PPDB SECARA ONLINE

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Muhammad Rizki Irwanto

2017-08-01

Full Text Available Tujuan penelitian ini untuk mengimplementasikan algoritma pada sistem in­formasi Penerimaan Peserta Didik Baru (PPDB secara online.Metode penelitian yang digunakan dalam pengembangan sistem informasi ini adalah metode pe­ngem­bang­an Waterfall. Tahap-tahap dalam metode pengembangan Waterfall, ada­lah: (1 de­finisi kebutuhan sistem, (2 desain sistem dan perangkat lunak, (3 im­ple­men­tasi dan pengujian unit, (4 integrasi dan sistem, dan (5 operasi dan pemeliharaan. Hasil uji coba sis­tem informasi oleh ahli rekayasa web dan admin sebesar 100,00%. Data hasil uji coba sistem informasi oleh guru sebesar 84,10%. Sedangkan data hasil uji coba sis­tem informasi oleh siswa sebesar 87,20%. Dari  data hasil uji coba di atas, dapat di­sim­pulkan bahwa sistem informasi ini sudah valid dan siap digunakan di sekolah.

MODEL PENYELESAIAN PERSELISIHAN PARTAI POLITIK SECARA INTERNAL MAUPUN EKSTERNAL (The Model of Political Party Dispute Settlement Internally and Externally

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Tri Cahya Indra Permana

2016-03-01

Full Text Available Undang-Undang Parpol mengatur bahwa perselisihan Parpol diselesaikan secara internal oleh Mahkamah Partai atau sebutan lain daripada itu dan secara eksternal oleh Pengadilan Negeri dan Mahkamah Agung. Substansi perselisihan yang final dan mengikat di Mahkamah Partai adalah perselisihan kepengurusan, selebihnya dapat diajukan upaya hukum ke Pengadilan Negeri dan Mahkamah Agung. Di dalam praktek, pengaturan tersebut telah menjauhkan dari rasa keadilan, kepastian hukum dan kemanfaatan, oleh karenanya sebaiknya direvisi yang mana perselisihan PAW, pelanggaran terhadap hak anggota partai politik, penyalahgunaan wewenang,  pertanggungjawaban keuangan, dan atau keberatan terhadap keputusan partai politik (termasuk keputusan untuk tidak memutuskan terhadap sesuatu hal final dan mengikat dengan Putusan MPP. Sedangkan perselisihan kepengurusan dapat diajukan upaya hukum ke Mahkamah Konstitusi. Political parties act stipulates that a political party dispute resolved internally by the Mahkamah Partai or other designation of that and externally resolved by the District Court and the Supreme Court. The dispute substance in Mahkamah Partai which is final and binding is about organization dispute, the other can be settled in District Court and the Supreme Court. In practice, that arrangement makes the decision apart from the sense of justice, legal certainty and utility. Therefore, these rules should be revised so that the regulation of PAW, violations of the rights of members of political parties, abuse of authority, financial liability, or an objection to the decision of political parties (including the decision not to decide on something is final and binding through Mahkamah Partai decision. While the organization disputes can be submitted to the Constitutional Court for legal action.

Faktor-faktor yang BerhubungandenganKetepatan Diagnosis Bidan Dalam Merujuk Pasien Kasus Kehamilan dan Persalinan Risiko Tinggi Ke RSUD Arifin Achmad Provinsi Riau Tahun 2014

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Desmariyanti .

2015-11-01

Full Text Available Ketepatan diagnosis merupakan ketepatan pendiagnosaan suatu kasus yang ditegakkan oleh petugas kesehatan dan telah memenuhi standar nomenklatur diagnosis. Bidan yang melakukan rujukan kehamilan dan persalinan risiko tinggi ke RSUD Arifin Achmad Provinsi Riau pada tahun 2014 sebanyak 210 kasus, dan yang tidak tepat mendiagnosis sebanyak 35 kasus (17%. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan ketepatan diagnosis bidan dalam merujuk pasien kasus kehamilan dan persalinan risiko tinggi yaitu pengetahuan, sikap, kompetensi, masa kerja dan bidan delima. Penelitian yang digunakan bersifat kuantitatif analitik observasional dengan studi penampang analitik (analitic crosssectional study. Analisis data dilakukan secara univariat, bivariat dengan uji chi square, dan multivariat dengan uji regresi logistik ganda dengan jumlah sampel sebanyak 120 orang yang diambil secara total populasi.Hasil penelitian diperoleh variabel yang berhubungan dengan ketepatan diagnosis bidan dalam merujuk pasien kasus kehamilan dan persalinan risiko tinggi adalah pengetahuan (OR:4,656; 95%CI: 1,200-18,064, kompetensi (OR:11,834; 95%CI: 1,371-102,141, dan masa kerja (OR:10,887; 95%CI: 2,657-44,602. Disarankan sebaiknya bidan mengikuti pelatihan APN, memiliki masa kerja yang optimal dan keterampilan dalam mengolah kasus kehamilan dan persalinan risiko tinggi, dan mengikuti seminar, workshop, pelatihan ataupun kegiatan yang dapat menambah ilmu pengetahuan khususnya ketepatan diagnosis kehamilan dan persalinan risiko tinggi

APLIKASI MONITORING PRAKTEK KERJA LAPANGAN SECARA ONLINE (STUDI KASUS JURUSAN TEKNIK ELEKTRO POLITEKNIK NEGERI BALI

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Sri Andriati Asri

2017-12-01

Full Text Available Mahasiswa Politeknik Negeri Bali melaksanakan Praktek Kerja Lapangan (PKL selama tiga bulan. Selama PKL mahasiswa diwajibkan untuk melaksanakan bimbingan dengan dosen pembimbing PKL. Dalam hal ini, jarak dan waktu menjadi kendala utama yang dialami mahasiswa PKL. Pengelolaan PKL yang telah berjalan selama ini ditangani oleh seorang koordinator. Pengelolaan  tersebut masih dilakukan secara manual, sehingga membutuhkan waktu yang lama dan rawan terjadi kesalahan. Untuk mengatasi hal tersebut peneliti mengembangkan sebuah aplikasi online bimbingan dan monitoring PKL. Aplikasi ini diharapkan mampu mengatasi kendala jarak dan waktu pada proses bimbingan dan membantu koordinator kegiatan PKL untuk membantu pengelolaan dengan lebih baik. Aplikasi dibuat dengan menggunakan metode waterfall, dengan PHP 5.6 dan MYSQL 5.6 sebagai bahasa pemrograman dan basis data. Aplikasi ini telah diujicoba ke pengguna dan dari hasil kuesioner diketahui 17,5% responden sangat setuju dan 82,5 % responden setuju bahwa aplikasi ini sangat membantu.

[Acute complicated and uncomplicated pyelonephritis in the emergency department: process-of-care indicators and outcomes].

Science.gov (United States)

Delgado Vicente, Miriam; Lecaroz Agara, Mª Concepción; Barrios Andrés, José Luis; Canut Blasco, Andrés

2017-02-01

To assess process-of-care indicators and outcomes in acute pyelonephritis (APN) in a general hospital emergency department, and compare them between uncomplicaed and complicated APN. Retrospective study of consecutive patients discharged with a diagnosis of APN. We studied health processof- care indicators (percentage admitted, avoidable hospitalization, appropriate initial antibiotic therapy, urine and blood cultures) and outcomes (hospital length of stay [LOS], discharge from the emergency department, revisits, mortality, yields of microbiological tests ordered). A total of 529 cases (59% of them complicated) were included. Patients with uncomplicated APN were significantly younger on average (mean, 39 years) than patients with complicated APN (56 years). Escherichia coli was the most common pathogen identified, although the percentage of E coli infection was lower in patients with complicated APN (78%) than in patients with uncomplicated APN (95%). The rates of admission and orders for urine and blood cultures were significantly higher and hospital LOS was longer in the group with complicated APN. Moreover, these patients had even longer stays if the initial antibiotic therapy was inappropriate. Significantly more patients with uncomplicated APN were discharged from the emergency department. Sixty-one percent of patients with uncomplicated APN were admitted; 9% of these cases were considered avoidable hospitalizations. Complicated APN is diagnosed more often in older patients, and E coli infection causes a smaller proportion of these cases. Hospital LOS is longer in complicated APN and more urine and blood cultures are ordered. Patients with uncomplicated APN are more often discharged from the emergency department, although the number of avoidable hospitalizations seems high based on the rate found in this study.

Factors influencing advanced practice nurses' ability to promote evidence-based practice among frontline nurses.

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Gerrish, Kate; Nolan, Mike; McDonnell, Ann; Tod, Angela; Kirshbaum, Marilyn; Guillaume, Louise

2012-02-01

Advanced practice nurses (APNs) have an important role in promoting evidence-based practice (EBP) among frontline nurses (FLNs). Factors influencing FLNs' engagement with EBP are well documented but little is known about factors that affect APNs' ability to facilitate evidence in practice. To identify factors that influence APNs' ability to promote EBP among FLNs. A multiple case study of 23 APNs from hospital and primary care settings across seven English health authorities was undertaken. Data collection comprised interviews and observation of APNs and interviews with FLNs and other healthcare professionals. Data were analysed using the Framework approach. Four groups of influencing factors were identified: (1) Personal attributes of APNs included knowledge and skills in EBP, clinical credibility with frontline staff and leadership style. (2) Relationships with stakeholders included APNs' interactions with FLNs and the level of support from managers and medical colleagues. (3) Aspects of the APN role included their sphere of responsibility and workload. (4) Organisational context included the organisational culture, FLNs' workload, professional networks and available resources. Educational preparation for APNs should enable them to develop expertise in EBP plus interpersonal and leadership skills to manage relational dynamics in clinical settings. APN role specifications should provide the opportunity to promote EBP. The organisational culture should be conducive to enabling EBP with managers supportive of this aspect of the APNs' role. APNs need to be supported to address the individual, interpersonal and organisational factors, which influence their ability to promote EBP. Organisational commitment at the highest level is key to APNs' ability to fulfil this aspect of their role. ©2011 Sigma Theta Tau International.

Horta orgânica de ervas medicinais: inclusão social na comunidade da Barra em Muriaé/MG - Brasil

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José Luiz de Freitas Paixão

2013-09-01

Full Text Available Foi implantada uma horta orgânica de ervas medicinais na comunidade da Barra (Muriaé, MG com o objetivo de inclusão social de pessoas carentes ao permitir acesso ao tratamento por fitoterapia. O início das atividades foi em janeiro de 2006, com a escolha das espécies, obtenção de mudas e instalação da horta. As 40 espécies selecionadas, sob manejo agroecológico, eram indicadas com terapêutica aos 25 principais problemas de saúde levantados na comunidade. O formato didático da horta, representando o corpo humano, serviu como referência às indicações de uso de cada espécie. A horta foi mantida até meados de 2012 na Barra e transferida ao IFMURIAÉ, em área de cultivo agroecológico, no Bairro Sofoco, onde se realizam as práticas do curso de técnico em agroecologia. A comunidade da Barra auxiliou desde as primeiras ações, sendo atuante na colheita das plantas medicinais. As plantas coletadas foram levadas a sala anexa à Paróquia local onde se realizou o processamento pós-colheita e o preparo de fitoterápicos. A dispensação dos preparados foi em outra sala cedida pela Paróquia. As formas fitoterápicas disponibilizadas à população foram de uso interno (erva seca, tintura, xarope e externo (creme, gel, pomada, sendo as mais procuradas: gel, tintura e xarope. De 2006 a 2012 foram  32.400 atendimentos, média de 385 pessoas/mês. O sucesso do projeto se reflete no aumento do número de espécies utilizadas, passando de 40 espécies em 2006 para 170 espécies em 2012, dentre elas: alecrim de jardim (Rosmarinus officinalis, alfavaca (Ocimum basilicum, amora (Morus alba, arnica brasileira (Solidago microglossa, calêndula (Calendula officinalis, camomila (Matricaria chamomilla, capim gordura (Melinis minutiflora, cavalinha (Equisetum arvense, chapéu-de-couro (Echinodorus grandiflorus e espinheira santa (Maytenus aquifolium.

Aminopeptidase-N-independent entry of porcine epidemic diarrhea virus into Vero or porcine small intestine epithelial cells.

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Ji, Chun-Miao; Wang, Bin; Zhou, Jiyong; Huang, Yao-Wei

2018-04-01

A monkey cell line Vero (ATCC CCL-81) is commonly used for porcine epidemic diarrhea virus (PEDV) propagation in vitro. However, it is still controversial whether the porcine aminopeptidase N (pAPN) counterpart on Vero cells (Vero-APN) confers PEDV entry. We found that endogenous expression of Vero-APN was undetectable in the mRNA and the protein levels in Vero cells. We cloned the partial Vero-APN gene (3340-bp) containing exons 1 to 9 from cellular DNA and subsequently generated two APN-knockout Vero cell lines by CRISPR/Cas9 approach. PEDV infection of two APN-knockout Vero cells had the same efficiency as the Vero cells with or without neuraminidase treatment. A Vero cells stably expressing pAPN did not increase PEDV production. SiRNA-knockdown of pAPN in porcine jejunum epithelial cells had no effects on PEDV infection. The results suggest that there exists an additional cellular receptor on Vero or porcine jejunal cells independent of APN for PEDV entry. Copyright © 2018 Elsevier Inc. All rights reserved.

Human milk adiponectin affects infant weight trajectory during the second year of life.

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Woo, Jessica G; Guerrero, M Lourdes; Guo, Fukun; Martin, Lisa J; Davidson, Barbara S; Ortega, Hilda; Ruiz-Palacios, Guillermo M; Morrow, Ardythe L

2012-04-01

Serum adiponectin (APN) is associated with lower childhood obesity, and APN concentration in human milk is associated with slower growth during active breast-feeding. We examined infant weight gain in the second year of life after exposure to high or low levels of mother's milk APN. Breast-feeding mother-infant pairs were recruited in Mexico City and studied for 2 years; 192 infants with at least 12 months' follow-up were analyzed. Monthly milk samples were assayed for APN; mothers were classified as producing high or low levels of milk APN. Infant and maternal serum APN were assessed during year 1. Infant anthropometry was measured monthly (year 1) or bimonthly (year 2), and World Health Organization z scores were calculated. Longitudinal adjusted models assessed weight-for-age and weight-for-length z score trajectories from 1 to 2 years. Maternal serum APN modestly correlated with milk APN (r=0.37, Pmilk APN experienced increasing weight-for-age and weight-for-length z scores between age 1 and 2 years in contrast to low milk APN exposure (P for group × time=0.02 and 0.054, respectively), adjusting for growth in the first 6 months and other covariates. In contrast, infant serum APN in year 1 was not associated with the rate of weight gain in year 2. High human milk APN exposure was associated with accelerated weight trajectory during the second year of life, suggesting its role in catch-up growth after slower weight gain during the first year of life.

E-selectin ligand-1 (ESL-1) is a novel adiponectin binding protein on cell adhesion

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Yamamoto, Hiroyasu; Kuroda, Nana; Uekita, Hiromi; Kochi, Ikoi; Matsumoto, Akane; Niinaga, Ryu [Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka (Japan); Funahashi, Tohru; Shimomura, Iichiro [Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka (Japan); Kihara, Shinji, E-mail: skihara@sahs.med.osaka-u.ac.jp [Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka (Japan)

2016-02-05

Background: Adiponectin (APN) is an adipocyte-derived bioactive molecule with anti-diabetic and anti-atherogenic properties. Although anti-diabetic effects are mostly mediated by the adiponectin receptors AdipoR1 and AdipoR2, the anti-atherogenic mechanisms have not been fully elucidated. Methods and Results: In this study, we identified E-selectin ligand (ESL)-1 as a novel APN-binding protein by mass spectrometry analysis of HepG2 cell-derived immunoprecipitant with an anti-APN antibody. Cell adhesion assays using fluorescence-labelled monocyte cell line THP-1 cells and human umbilical vein endothelial cells (HUVECs) revealed that APN-pre-treated THP-1 cells had reduced binding ability to HUVECs. This APN-mediated suppressive effect on monocyte binding to endothelial cells was partially abrogated by targeting ESL-1 with shRNA in THP-1 cells. In addition, serial mutagenesis analysis disclosed that five extracellular amino acids close to the N-terminus of ESL-1 were essential for binding with APN. Conclusion: Our results highlight the fact that interaction between APN and ESL-1 could provide a fundamental mechanism underlying the anti-atherogenic properties of APN. - Highlights: • E-selectin ligand (ESL)-1 was identified as an adiponectin (APN)-binding protein. • ESL-1 bound to APN at its N-terminal 6th-10th amino acids. • shESL-1 reduced the suppressive effect of APN on adhesion of THP-1 cells to HUVECs. • Interaction with ESL may be involved in the anti-atherogenic effects of APN.

E-selectin ligand-1 (ESL-1) is a novel adiponectin binding protein on cell adhesion

International Nuclear Information System (INIS)

Yamamoto, Hiroyasu; Kuroda, Nana; Uekita, Hiromi; Kochi, Ikoi; Matsumoto, Akane; Niinaga, Ryu; Funahashi, Tohru; Shimomura, Iichiro; Kihara, Shinji

2016-01-01

Background: Adiponectin (APN) is an adipocyte-derived bioactive molecule with anti-diabetic and anti-atherogenic properties. Although anti-diabetic effects are mostly mediated by the adiponectin receptors AdipoR1 and AdipoR2, the anti-atherogenic mechanisms have not been fully elucidated. Methods and Results: In this study, we identified E-selectin ligand (ESL)-1 as a novel APN-binding protein by mass spectrometry analysis of HepG2 cell-derived immunoprecipitant with an anti-APN antibody. Cell adhesion assays using fluorescence-labelled monocyte cell line THP-1 cells and human umbilical vein endothelial cells (HUVECs) revealed that APN-pre-treated THP-1 cells had reduced binding ability to HUVECs. This APN-mediated suppressive effect on monocyte binding to endothelial cells was partially abrogated by targeting ESL-1 with shRNA in THP-1 cells. In addition, serial mutagenesis analysis disclosed that five extracellular amino acids close to the N-terminus of ESL-1 were essential for binding with APN. Conclusion: Our results highlight the fact that interaction between APN and ESL-1 could provide a fundamental mechanism underlying the anti-atherogenic properties of APN. - Highlights: • E-selectin ligand (ESL)-1 was identified as an adiponectin (APN)-binding protein. • ESL-1 bound to APN at its N-terminal 6th-10th amino acids. • shESL-1 reduced the suppressive effect of APN on adhesion of THP-1 cells to HUVECs. • Interaction with ESL may be involved in the anti-atherogenic effects of APN.

The anti-inflammatory effect of Andrographis paniculata (Burm. f.) Nees on pelvic inflammatory disease in rats through down-regulation of the NF-κB pathway.

Science.gov (United States)

Zou, Wei; Xiao, Zuoqi; Wen, Xiaoke; Luo, Jieying; Chen, Shuqiong; Cheng, Zeneng; Xiang, Daxiong; Hu, Jian; He, Jingyu

2016-11-25

Andrographis paniculata (Burm. f.) Nees (APN), a principal constituent of a famous traditional Chinese medicine Fukeqianjin tablet which is used for the treatment of pelvic inflammatory disease (PID), has been reported to have anti-inflammatory effect in vitro. However, whether it has pharmacological effect on PID in vivo is unclear. Therefore, the aim of this study is to test the anti-inflammatory effect of APN and illuminate a potential mechanism. Thirty-six female specific pathogen-free SD rats were randomly divided into control group, PID group, APN1 group, APN2 group, APN3 group and prednisone group. Pathogen-induced PID rats were constructed. The APN1, APN2 and APN3 group rats were orally administrated with APN extract at different levels. The prednisone group rats were administrated with prednisone. Eight days after the first infection, the histological examination of upper genital tract was carried out, and enzyme-linked immunosorbent assay (ELISA) was carried out using homogenate of the uterus and fallopian tube. Furthermore, immunohistochemical evaluations of NF-κB p65 and IκB-α in uterus was conducted. APN obviously suppressed the infiltrations of neutrophils and lymphocytes, and it could significantly reduce the excessive production of cytokines and chemokines including IL-1β, IL-6, CXCL-1, MCP-1 and RANTES in a dose-dependent manner. Furthermore, APN could block the pathogen-induced activation of NF-κB pathway. APN showed potent anti-inflammatory effect on pathogen-induced PID in rats, with a potential mechanism of inhibiting the NF-κB signal pathway.

Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment.

Science.gov (United States)

Guzman-Rojas, Liliana; Rangel, Roberto; Salameh, Ahmad; Edwards, Julianna K; Dondossola, Eleonora; Kim, Yun-Gon; Saghatelian, Alan; Giordano, Ricardo J; Kolonin, Mikhail G; Staquicini, Fernanda I; Koivunen, Erkki; Sidman, Richard L; Arap, Wadih; Pasqualini, Renata

2012-01-31

Processes that promote cancer progression such as angiogenesis require a functional interplay between malignant and nonmalignant cells in the tumor microenvironment. The metalloprotease aminopeptidase N (APN; CD13) is often overexpressed in tumor cells and has been implicated in angiogenesis and cancer progression. Our previous studies of APN-null mice revealed impaired neoangiogenesis in model systems without cancer cells and suggested the hypothesis that APN expressed by nonmalignant cells might promote tumor growth. We tested this hypothesis by comparing the effects of APN deficiency in allografted malignant (tumor) and nonmalignant (host) cells on tumor growth and metastasis in APN-null mice. In two independent tumor graft models, APN activity in both the tumors and the host cells cooperate to promote tumor vascularization and growth. Loss of APN expression by the host and/or the malignant cells also impaired lung metastasis in experimental mouse models. Thus, cooperation in APN expression by both cancer cells and nonmalignant stromal cells within the tumor microenvironment promotes angiogenesis, tumor growth, and metastasis.

PERANCANGAN KENDALI NAVIGASI ROBOT TANK SECARA NIRKABEL BERBASIS SENSOR ACCELEROMETER BERDASARKAN GERAKAN TANGAN

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Muhamad Yusvin Mustar

2018-04-01

Full Text Available Sebuah sistem kendali berbeda pada navigasi robot tank diperkenalkan pada penelitian ini. Umumnya sistem kendali navigasi robot tank dikendalikan meggunakan remot kontrol atau joystick dan beberapa perangkat pengontrolan robot lainya. Pengontrolan navigasi robot tank bertujuan untuk dapat mengendalikan pergerakan robot agar dapat berjalan maju, mundur, berbelok ke kiri dan ke kanan. Pada penelitian ini, pengontrolan navigasi robot dilakukan berdasarkan gerakan tangan manusia. Sebuah sarung tangan yang dilengkapi sensor accelerometer ADXL335 didesain untuk dapat mendeteksi setiap bentuk gerakan tangan. Pendeteksian gerakan tangan didasarkan pada pembacaan orientasi axis X dan Y acceleometer. Gerakan tangan ini kemudian diinput pada mikrokontroler Arduino Nano dan ditransmisikan melalui nRF24L01 2.4GHz. Hasil pendeteksian gerak kemudian diterima dan diolah pada mikrokontroler Arduino Mega yang terdapat pada robot tank. Selanjutnya, hasil pendeteksian gerakan tangan ini dipetakan dalam beberapa bagian pengontrolan, agar sesuai dengan pola pengontrolan navigasi robot tank. Hasil penelitian ini menunjukan bahwa sebuah sistem pengontrolan navigasi robot tank berdasarkan gerakan tangan dapat diimplementasikan dan diaplikasikan secara riil, sehingga dapat memberikan pengalaman baru dalam berinteraksi dengan robot. Kata kunci: navigasi, robot tank, deteksi gerakan, accelerometer ADXL335, arduino, nRF24L01.

Study on curing reaction of 4-aminophenoxyphthalonitrile/bisphthalonitrile

Institute of Scientific and Technical Information of China (English)

Xiao

2010-01-01

A series of phthalonitrile blending resins were prepared from 4-aminophenoxyphthalonitrile (APN) and 4,4'-bis (3,4-dicyanophenoxy)biphenyl (BPH) by directly powder-mixing and copolymerization. Differential scanning calorimeter (DSC) and dynamic rheology were used to study the curing reaction behaviors of APN/BPH blends, and the results indicated that the introduction of APN accelerated the curing rate of BPH, and the existence of BPH decreased the curing temperature of APN/BPH systems. The thermal stability of postcured APN/BPH resins was investigated by thermogravimetric analysis (TGA), and the TGA results indicated that the crosslinked polymers of APN/BPH systems possessed good thermal stability.

Globular Adiponectin Attenuated H2O2-Induced Apoptosis in Rat Chondrocytes by Inducing Autophagy Through the AMPK/ mTOR Pathway.

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Hu, Junzheng; Cui, Weiding; Ding, Wenxiao; Gu, Yanqing; Wang, Zhen; Fan, Weimin

2017-01-01

Chondrocyte apoptosis is closely related to the development and progression of osteoarthritis. Global adiponectin (gAPN), secreted from adipose tissue, possesses potent anti-inflammatory and antiapoptotic properties in various cell types. This study aimed to investigate the role of autophagy induced by gAPN in the suppression of H2O2-induced apoptosis and the potential mechanism of gAPN-induced autophagy in chondrocytes. H2O2 was used to induce apoptotic injury in rat chondrocytes. CCK-8 assay was performed to determine the viability of cells treated with different concentrations of gAPN with or without H2O2. Cell apoptosis was detected by flow cytometry and TUNEL staining. Mitochondrial membrane potential was examined using JC-1 fluorescence staining assay. The autophagy inhibitors 3-MA and Bafilomycin A1 were used to treat cells and then evaluate the effect of gAPN-induced autophagy. To determine the downstream pathway, chondrocytes were preincubated with the AMPK inhibitor Compound C. Beclin-1, LC3B, P62 and apoptosis-related proteins were identified by Western blot analysis. H2O2 (400 µM)-induced chondrocytes apoptosis and caspase-3 activation were attenuated by gAPN (0.5 µg/mL). gAPN increased Bcl-2 expression and decreased Bax expression. The loss of mitochondrial membrane potential induced by H2O2 was also abolished by gAPN. Furthermore, the antiapoptotic effect of gAPN was related to gAPN-induced autophagy by increased formation of Beclin-1 and LC3B and P62 degradation. In particular, the inhibition of gAPN-induced autophagy by 3-MA prevented the protective effect of gAPN on apoptosis induced by H2O2. Moreover, gAPN increased p-AMPK expression and decreased p-mTOR expression. Compound C partly suppressed the expression of autophagy-related proteins and restored the expression of p-mTOR suppressed by gAPN. Thus, the AMPK/mTOR pathway played an important role in the induction of autophagy and protection of H2O2-induced chondrocytes apoptosis by gAPN. gAPN

Globular Adiponectin Attenuated H2O2-Induced Apoptosis in Rat Chondrocytes by Inducing Autophagy Through the AMPK/ mTOR Pathway

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Junzheng Hu

2017-08-01

Full Text Available Background/Aims: Chondrocyte apoptosis is closely related to the development and progression of osteoarthritis. Global adiponectin (gAPN, secreted from adipose tissue, possesses potent anti-inflammatory and antiapoptotic properties in various cell types. This study aimed to investigate the role of autophagy induced by gAPN in the suppression of H2O2-induced apoptosis and the potential mechanism of gAPN-induced autophagy in chondrocytes. Methods: H2O2 was used to induce apoptotic injury in rat chondrocytes. CCK-8 assay was performed to determine the viability of cells treated with different concentrations of gAPN with or without H2O2. Cell apoptosis was detected by flow cytometry and TUNEL staining. Mitochondrial membrane potential was examined using JC-1 fluorescence staining assay. The autophagy inhibitors 3-MA and Bafilomycin A1 were used to treat cells and then evaluate the effect of gAPN-induced autophagy. To determine the downstream pathway, chondrocytes were preincubated with the AMPK inhibitor Compound C. Beclin-1, LC3B, P62 and apoptosis-related proteins were identified by Western blot analysis. Results: H2O2 (400 µM-induced chondrocytes apoptosis and caspase-3 activation were attenuated by gAPN (0.5 µg/mL. gAPN increased Bcl-2 expression and decreased Bax expression. The loss of mitochondrial membrane potential induced by H2O2 was also abolished by gAPN. Furthermore, the antiapoptotic effect of gAPN was related to gAPN-induced autophagy by increased formation of Beclin-1 and LC3B and P62 degradation. In particular, the inhibition of gAPN-induced autophagy by 3-MA prevented the protective effect of gAPN on apoptosis induced by H2O2. Moreover, gAPN increased p-AMPK expression and decreased p-mTOR expression. Compound C partly suppressed the expression of autophagy-related proteins and restored the expression of p-mTOR suppressed by gAPN. Thus, the AMPK/mTOR pathway played an important role in the induction of autophagy and protection of

AKTIVITAS ANTIMIKROBA YOGURT BERBASIS AIR KELAPA MENGHAMBAT BAKTERI PATOGEN SECARA IN VITRO

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Lindawati S. A.

2014-11-01

Full Text Available Yogurt merupakan minuman susu yang difermentasi dengan menggunakan bakteri asam laktat Lactobacillus bulgaricus dan Streptococcus thermophyllus sebagai starter. Tujuan penelitian untuk mengetahui kemampuan tertinggi dari yogurt berbasis air kelapa dalam menghambat pertumbuhan bakteri pathogen (Salmonella, Staphylococcus, Klebsiela pneumonia dan E.coli secara in vitro. Penelitian ini menggunakan rancangan acak lengkap (RAL dengan empat perlakuan dan empat ulangan. Keempat perlakuan tersebut: Ko: susu skim 12%+air; K1: susu skim 12%+air kelapa gading; K2: susu skim 12%+kelapa gading bulan; K3: susu skim 12%+air kelapa hijau. Peubah yang diamati adalah aktivitas antimikroba yogurt terhadap bakteri pathogen (Salmonellatyphi, Staphylococcus, Klebsiella pneumonia dan E.coli, total plate count (TPC, total bakteri asam laktat dan E,coli. Hasil penelitian menunjukkan bahwa aktivitas antimikroba tertinggi diperoleh pada yogurt berbasis air kelapa bulan terhadap bakeri Salmonella typhi dan Staphylococcus masing-masing sebesar 0,21 dan 0,26 cm dengan total bakteri asam laktat1,1×107 cfu/mL sedangkan untuk Klebsiella pneumonia dan E.coli diperoleh pada yogurt berbasis air kelapa gading sebesar 0,38 dan 0,64 mm dengan total bakteri asam laktat 3,1×106 cfu/mL.Dari hasil penelitian dapat disimpulkan bahwa yogurt berbasis air kelapa gading, bulan, hijau dan tanpa air kelapa memiliki aktivitas antimikroba berspektrum luas (menghambat bakteri gram positif dan negatif.

Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Disease Severity

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Kang Tang

2017-01-01

Full Text Available Haemorrhagic fever with renal syndrome (HFRS is characterised by an uncontrolled immune response that causes vascular leakage. Adiponectin (APN is an adipocytokine involved in prorevascularisation and immunomodulation. To investigate the possible effects of APN in the pathogenesis of HFRS, total and high molecular weight (HMW APN levels in the plasma of patients with HFRS were quantified using enzyme-linked immunosorbent assay (ELISA. Compared with those in healthy controls, the plasma total and HMW APN levels in patients were elevated to different degrees from the fever onset and remained high at the convalescent phase. Consistent with these results, western blot analysis additionally showed that low molecular weight (LMW, middle molecular weight (MMW, and HMW APN levels were all elevated and contributed to the elevation of the total APN level. Importantly, sustained high levels of total and HMW APN at the convalescent phase were significantly higher in patients with critical disease than those in patients with mild or moderate disease. Moreover, total and HMW APN levels negatively correlated with white blood cell count and positively correlated with platelet count and serum albumin level. These results may provide insights into understanding the roles of total and HMW APN in the pathogenesis of HFRS.

Identification and Characterization of Hyphantria cunea Aminopeptidase N as a Binding Protein of Bacillus thuringiensis Cry1Ab35 Toxin

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Yakun Zhang

2017-11-01

Full Text Available The fall webworm, Hyphantria cunea (Drury is a major invasive pest in China. Aminopeptidase N (APN isoforms in lepidopteran larvae midguts are known for their involvement in the mode of action of insecticidal crystal (Cry proteins from Bacillus thuringiensis. In the present work, we identified a putative Cry1Ab toxin-binding protein, an APN isoform designated HcAPN3, in the midgut of H. cunea by ligand blot and mass spectrometry. HcAPN3 was highly expressed throughout all larval developmental stages and was abundant in the midgut and hindgut tissues. HcAPN3 was down-regulated at 6 h, then was up-regulated significantly at 12 h and 24 h after Cry1Ab toxin treatment. We expressed HcAPN3 in insect cells and detected its interaction with Cry1Ab toxin by ligand blot assays. Furthermore, RNA interference (RNAi against HcAPN3 using oral delivery and injection of double-stranded RNA (dsRNA resulted in a 61–66% decrease in transcript level. Down-regulating of the expression of HcAPN3 was closely associated with reduced susceptibility of H. cunea to Cry1Ab. In addition, the HcAPN3E fragment peptide expressed in Escherichia coli enhanced Cry1Ab toxicity against H. cunea larvae. This work represents the first evidence to suggest that an APN in H. cunea is a putative binding protein involved in Cry1Ab susceptibility.

Globular Adiponectin Inhibits the Apoptosis of Mesenchymal Stem Cells Induced by Hypoxia and Serum Deprivation via the AdipoR1-Mediated Pathway

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Xia-Qiu Tian

2016-02-01

Full Text Available Background/Aims: Poor viability of transplanted mesenchymal stem cells (MSCs within the ischemic heart limits their therapeutic potential for cardiac repair. Globular adiponectin (gAPN exerts anti-apoptotic effects on several types of stem cells. Herein, we investigated the effect of gAPN on the MSCs against apoptosis induced by hypoxia and serum deprivation (H/SD. Methods: MSCs exposed to H/SD conditions were treated with different concentrations of gAPN. To identify the main type of receptor, MSCs were transfected with siRNA targeting adiponectin receptor 1 or 2 (AdipoR1 or AdipoR2. To elucidate the downstream pathway, MSCs were pre-incubated with AMPK inhibitor Compound C. Apoptosis, caspase-3 activity and mitochondrial membrane potential were evaluated. Results: H/SD-induced MSCs apoptosis and caspase-3 activation were attenuated by gAPN in a concentration-dependent manner. gAPN increased Bcl-2 and decreased Bax expressions. The loss of mitochondrial membrane potential induced by H/SD was also abolished by gAPN. The protective effect of gAPN was significantly attenuated after the knockdown of AdipoR1 rather than AdipoR2. Moreover, Compound C partly suppressed the anti-apoptotic effect of gAPN. Conclusions: gAPN inhibits H/SD-induced apoptosis in MSCs via AdipoR1-mediated pathway, possibly linked to the activation of AMPK. gAPN may be a novel survival factor for MSCs in the ischemic engraftment environment.

Globular Adiponectin Inhibits the Apoptosis of Mesenchymal Stem Cells Induced by Hypoxia and Serum Deprivation via the AdipoR1-Mediated Pathway.

Science.gov (United States)

Tian, Xia-Qiu; Yang, Yue-Jin; Li, Qing; Huang, Pei-Sen; Li, Xiang-Dong; Jin, Chen; Qi, Kang; Jiang, Lei-Pei; Chen, Gui-Hao

2016-01-01

Poor viability of transplanted mesenchymal stem cells (MSCs) within the ischemic heart limits their therapeutic potential for cardiac repair. Globular adiponectin (gAPN) exerts anti-apoptotic effects on several types of stem cells. Herein, we investigated the effect of gAPN on the MSCs against apoptosis induced by hypoxia and serum deprivation (H/SD). MSCs exposed to H/SD conditions were treated with different concentrations of gAPN. To identify the main type of receptor, MSCs were transfected with siRNA targeting adiponectin receptor 1 or 2 (AdipoR1 or AdipoR2). To elucidate the downstream pathway, MSCs were pre-incubated with AMPK inhibitor Compound C. Apoptosis, caspase-3 activity and mitochondrial membrane potential were evaluated. H/SD-induced MSCs apoptosis and caspase-3 activation were attenuated by gAPN in a concentration-dependent manner. gAPN increased Bcl-2 and decreased Bax expressions. The loss of mitochondrial membrane potential induced by H/SD was also abolished by gAPN. The protective effect of gAPN was significantly attenuated after the knockdown of AdipoR1 rather than AdipoR2. Moreover, Compound C partly suppressed the anti-apoptotic effect of gAPN. gAPN inhibits H/SD-induced apoptosis in MSCs via AdipoR1-mediated pathway, possibly linked to the activation of AMPK. gAPN may be a novel survival factor for MSCs in the ischemic engraftment environment. © 2016 The Author(s) Published by S. Karger AG, Basel.

The climate impact on female acute pyelonephritis in Taiwan: A population-based study.

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Liu, Jui-Ming; Chang, Yu-Lung; Hsu, Ren-Jun; Su, Her-Young; Teng, Sen-Wen; Chang, Fung-Wei

2017-08-01

Urinary tract infection (UTI) is the main reason of community-acquired infection which causes large losses in social economy. The individual as well as climate factors make changes on the incidence. Acute pyelonephritis (APN) is one of the most serious UTI in female. The object of our study is to analyze whether climate factors will have effect on the incidence of female APN in Taiwan. This study consisted of 14,568 female patients with APN from 2001 to 2013 in Taiwan and patients with repeated APN were excluded. The monthly climate data was collected from the Central Weather Bureau. The available monthly climate data included highest, lowest, and average level of temperatures, humidity, rainfall, total rain days, and sunshine hours. The total incidence of female APN was 23.44 each 10,000 populations. The incidence of APN was positively correlated with temperature (r = 0.66), sunshine hours (r = 0.45), rainfall (r = 0.42), rain days (r = 0.29), and humidity (r = 0.23) per month. There is the strongest correlation between the average monthly temperature and the incidence of APN (β = 0.54). The correlation with the incidence of APN was also followed by rain days (β = 0.28) and humidity (β = 0.27). There is a significant expression on the incidence of female APN affected by seasonality and climate parameters. The monthly average temperature has the strongest correlation with female APN. The results of this research may facilitate the potential preventive strategies on female APN. Copyright © 2017. Published by Elsevier B.V.

Vermisidal dan Ovisidal Ekstrak Daun Pepaya Terhadap Cacing Ascaris suum Secara In Vitro

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Agung Mourizd Adventus Bili Bora

2014-05-01

Full Text Available Tujuan penelitian ini untuk mengetahui vermisidal dan ovisidal dari ekstrak daun pepaya terhadap cacing Ascaris suum. Menggunakan  Rancangan  Acak  Lengkap (RAL, dengan perlakuan beberapa konsentrasi ekstrak daun pepaya 1,5%, 3%, 4,5% dan 6%; kontrol negatif menggunakan NaCl fisiologis dan kontrol positif menggunakan Albendazole 0,12%. Dilakukan uji vermisidal dan uji  ovisidal, uji ovisidal dibagi  menjadi  dua  uji,  yaitu kontak langsung dan kontak tidak  langsung. Untuk uji vermisidal data dianalisis dengan Analisis Probit untuk mengetahui LC100 (Lethal concentration dan LT100 (Lethal  time, sedangkan  untuk  uji  ovisidal  data dianalisis dengan Sidik Ragam dan  jika terdapat perbedaan, dilanjutkan dengan uji jarak berganda Duncan. Hasil  penelitian  vermisidal  didapatkan  LC100 ekstrak  daun  pepaya adalah  3,362%  dan  LT100 39,822  jam.  Untuk  uji  ovisidal  kontak  langsung  dan kontak tidak langsung didapatkan ekstrak daun pepaya berpengaruh sangat nyata (P<0,01 terhadap daya berembrio telur A. suum. Dari hasil penelitian ini disimpulkan bahwa ekstrak daun pepaya efektif sebagai vermisidal dan ovisidal terhadap cacing A. suum secara in-vitro.

Implementation and evaluation of a peer review process for advanced practice nurses in a university hospital setting.

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Bergum, Shelly K; Canaan, Talitha; Delemos, Christi; Gall, Elizabeth Funke; McCracken, Bonnie; Rowen, Dave; Salvemini, Steve; Wiens, Kimberly

2017-07-01

Over the past decade, implementation of the peer review process for the development of the advanced practice nurse (APN) has been emphasized. However, little exists in the literature regarding APN peer review. The peer review process is intended to help demonstrate competency of care, enhance quality improvement measures, and foster the professional growth of the APN. APNs serving on a professional governance council within a university teaching hospital developed a model of peer review for APNs. Nine months after the tool was implemented, an anonymous follow-up survey was conducted. A follow-up request was sent 4 weeks later to increase the number of respondents. Likert scales were used to elicit subjective data regarding the process. Of 81 APNs who participated in the survey, more than half (52%) felt that the process would directly improve their professional practice. Survey results show that the peer review process affected APN professional practice positively. Additional research might include pathways for remediation and education of staff, evaluation of alternate methods to improve application to clinical practice, and collection of outcome data. The models presented provide a foundation for future refinement to accommodate different APN practice settings. ©2017 American Association of Nurse Practitioners.

E-selectin ligand-1 (ESL-1) is a novel adiponectin binding protein on cell adhesion.

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Yamamoto, Hiroyasu; Kuroda, Nana; Uekita, Hiromi; Kochi, Ikoi; Matsumoto, Akane; Niinaga, Ryu; Funahashi, Tohru; Shimomura, Iichiro; Kihara, Shinji

2016-02-05

Adiponectin (APN) is an adipocyte-derived bioactive molecule with anti-diabetic and anti-atherogenic properties. Although anti-diabetic effects are mostly mediated by the adiponectin receptors AdipoR1 and AdipoR2, the anti-atherogenic mechanisms have not been fully elucidated. In this study, we identified E-selectin ligand (ESL)-1 as a novel APN-binding protein by mass spectrometry analysis of HepG2 cell-derived immunoprecipitant with an anti-APN antibody. Cell adhesion assays using fluorescence-labelled monocyte cell line THP-1 cells and human umbilical vein endothelial cells (HUVECs) revealed that APN-pre-treated THP-1 cells had reduced binding ability to HUVECs. This APN-mediated suppressive effect on monocyte binding to endothelial cells was partially abrogated by targeting ESL-1 with shRNA in THP-1 cells. In addition, serial mutagenesis analysis disclosed that five extracellular amino acids close to the N-terminus of ESL-1 were essential for binding with APN. Our results highlight the fact that interaction between APN and ESL-1 could provide a fundamental mechanism underlying the anti-atherogenic properties of APN. Copyright © 2016 Elsevier Inc. All rights reserved.

PENERAPAN PEMBELAJARAN DENGAN PENDIDIKAN MATEMATIKA REALISTIK (PMR SECARA BERKELOMPOK UNTUK MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIS SISWA DI KELAS X SMA

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Atik Krismiati

2013-09-01

Full Text Available Tujuan dari penelitian ini adalah untuk mengetahui peningkatan kemampuan pemecahan masalah matematis serta kinerja siswa. Subyek populasi dalam penelitian ini adalah siswa SMA Aloysius Bandung. Pendekatan yang digunakan dengan PMR. Instrumen yang digunakan terdiri dari: tes kemampuan pemecahan masalah dan aktivitas siswa selama pembelajaran. Secara keseluruhan siswa yang pembelajaran pemecahan masalah dengan metode PMR lebih baik dalam meningkatkan kemampuan pemecahan masalah, yaitu terlihat dengan adanya peningkatan dari siklus I ke siklus II. Kesulitan siswa terutama pada permasalahan dengan aspek argumentasi dan keakuratan. Selain itu kelebihan dari metode ini siswa lebih terlihat menyukai yaitu terlihat dengan antusiasnya mengerjakan tugas-tugas dari guru serta memberi alasan secara geometri, kreativitas, dan generalisasi yang sebagian besar perwujudannya dilakukan oleh siswa sendiri. Berdasarkan respon dan hasil akhir LKS menunjukkan aktivitas, dan kinerja yang lebih meningkatkan untuk setiap siklusnya Kata Kunci : Pendidikan Matematika Realistik, Pemecahan Masalah Matematis     The purpose of this study is to determine the increase in mathematical problem-solving skills as the well as student performance. The population subjects in this study are the high school students Aloysius Bandung . The approach applied is PMR . The used instruments consisted of : problem solving ability testing and students activities during the learning process. Overall, the students who are applying PMR method is better, which is seen from the increasing cycle I to cycle II. The primary students difficulties are on problems with aspects of argumentation and accuracy. However the advantages of this method the students look more enthusiastic in doing the tasks given are by the teachers, and they are also able to give geometrical and creative reasons. Which most of its manifestations are generally made by the students themselves. Based on the response and the

Alterações cardiovasculares na síndrome da apnéia obstrutiva do sono Cardiovascular comorbidities and obstructive sleep apnea

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Fátima Dumas Cintra

2006-06-01

Full Text Available A síndrome da apnéia obstrutiva do sono (SAHOS é uma condição prevalente na população, associada a maior risco cardiovascular, freqüentemente não-diagnosticada. O reconhecimento da síndrome requer alto grau de suspeita clínica, especialmente por cardiologistas, e pode ser confirmada por meio da polissonografia. O tratamento da síndrome com o uso de CPAP (pressão positiva na via aérea superior é altamente eficaz, melhorando o padrão respiratório durante o sono, instituindo o sono reparador e, dessa forma, otimizando a qualidade de vida desses pacientes, além de atenuar ou reverter muitas das complicações cardiovasculares relacionadas a SAHOS. Este artigo aborda a fisiopatologia e os aspectos clínicos das comorbidades cardiovasculares associadas à síndrome.Obstructive sleep apnea-hypopnea syndrome (OSAHS is a prevalent condition in the general population. It is associated with increased cardiovascular risk and often goes unrecognized. Its diagnose requires a high degree of clinical suspicion, particularly on the part of cardiologists, and it may be confirmed by polysomnography. Continuous positive airway pressure (CPAP therapy is highly effective, since it improves sleep breathing pattern, promotes restful sleep and thus enhances the quality of life of these patients, in addition to attenuating or reversing many cardiovascular complications related to OSAHS. This paper addresses the pathophysiology and clinical features of cardiovascular comorbidities associated with the syndrome.

Aminopeptidase N/CD13 as a Potential Therapeutic Target in Malignant Pleural Mesothelioma.

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Otsuki, Takahiko; Nakashima, Taku; Hamada, Hironobu; Takayama, Yusuke; Akita, Shin; Masuda, Takeshi; Horimasu, Yasushi; Miyamoto, Shintaro; Iwamoto, Hiroshi; Fujitaka, Kazunori; Miyata, Yoshihiro; Miyake, Masayuki; Kohno, Nobuoki; Okada, Morihito; Hattori, Noboru

2018-03-08

Angiogenesis is a crucial factor in the progression of malignant pleural mesothelioma (MPM), and antiangiogenic strategies might be effective against MPM. Aminopeptidase N/CD13 (APN/CD13) promotes tumour angiogenesis and is associated with poor prognosis; however, its clinical significance in MPM remains unclear.In 37 consecutive patients with surgically resected MPM, we evaluated the association between immunohistochemical APN/CD13 expression in resected tumours and survival. Additionally, the antitumour and antiangiogenic effects of MT95-4, a fully humanized anti-APN/CD13 monoclonal antibody, were evaluated in mice orthotopically implanted with EHMES-10 (abundantly expressing APN/CD13) and MSTO-211H (scarcely expressing APN/CD13) MPM cells.High tumour APN/CD13 expression was associated with poor prognosis in MPM patients ( P =0.04), and MT95-4 treatment reduced tumour growth and angiogenesis in mice harbouring EHMES-10, but not MSTO-211H, cells. Furthermore, in mice harbouring EHMES-10 cells, MT95-4 combined with cisplatin more effectively suppressed tumour progression than cisplatin alone.Taken together these results suggested that APN/CD13 is implicated in the aggressiveness of MPM. Here, MT95-4 treatment reduced tumour progression likely by inhibiting angiogenesis, suggesting APN/CD13 as a potential molecular target for MPM treatment. Additionally, combination treatment with MT95-4 and cisplatin could represent a promising approach to treating MPM exhibiting high APN/CD13 expression. Copyright ©ERS 2018.

Transport of beta-aminopropionitrile through intact skin or scar tissue

International Nuclear Information System (INIS)

Gibeault, J.D.; Cravens, R.B. Jr.; Chvapil, M.

1989-01-01

A lathyrogen, [ 14 C]aminopropionitrile (beta APN), was administered to 34 rats either in K-Y jelly or saline vehicles onto intact shaven skin or onto a healed splinted deep excision wound. The dynamics of beta APN transport and content in the skin or repair tissue was observed after 2, 5, 8, and 24 hr of topical administration. The repair tissue quickly absorbed the lathyrogen and reached maximum at the 2-hr sampling. The content of beta APN in the repair tissue was twice as high as that in K-Y jelly vehicle and remained high and stable for at least 24 hr only when beta APN was administered through a saline vehicle. The transport of beta APN through intact skin, irrespective of the vehicle tested, was slow and continuously increased. The study showed that almost 20% of the beta APN administered onto the wounded skin area was transported into the repair tissue within 2 hr. We suggest that, due to the absence of epidermal stratum corneum from the repair tissue, drugs, such as beta APN, penetrate quickly into the wound

Plasma Adiponectin, clinical factors, and patient outcomes during the acute respiratory distress syndrome.

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Allan J Walkey

Full Text Available Adiponectin (APN is an anti-inflammatory hormone derived from adipose tissue that attenuates acute lung injury in rodents. In this study, we investigated the association between circulating APN and outcomes among patients with acute respiratory distress syndrome (ARDS.We performed a retrospective cohort study using data and plasma samples from participants in the multicenter ARDS Network Fluid and Catheter Treatment Trial.Plasma APN concentrations were measured in 816 (81.6% trial participants at baseline and in 568 (56.8% subjects at both baseline and day 7 after enrollment. Clinical factors associated with baseline APN levels in multivariable-adjusted models included sex, body mass index, past medical history of cirrhosis, and central venous pressure (model R2 = 9.7%. We did not observe an association between baseline APN and either severity of illness (APACHE III or extent of lung injury (Lung Injury Score. Among patients who received right heart catheterization (n = 384, baseline APN was inversely related to mean pulmonary artery pressure (β = -0.015, R2 1.5%, p = 0.02; however, this association did not persist in multivariable models (β = -0.009, R2 0.5%, p = 0.20. Neither baseline APN levels [HR per quartile1.04 (95% CI 0.91-1.18, p = 0.61], nor change in APN level from baseline to day 7 [HR 1.04 (95% CI 0.89-1.23, p = 0.62] were associated with 60 day mortality in Cox proportional hazards regression models. However, subgroup analysis identified an association between APN and mortality among patients who developed ARDS from extra-pulmonary etiologies [HR per quartile 1.31 (95% CI 1.08-1.57]. APN levels did not correlate with mortality among patients developing ARDS in association with direct pulmonary injury [HR 0.96 (95% CI 0.83-1.13], pinteraction = 0.016.Plasma APN levels did not correlate with disease severity or mortality in a large cohort of patients with ARDS. However, higher APN levels were

Adiponectin attenuates lung fibroblasts activation and pulmonary fibrosis induced by paraquat.

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Rong Yao

Full Text Available Pulmonary fibrosis is one of the most common complications of paraquat (PQ poisoning, which demands for more effective therapies. Accumulating evidence suggests adiponectin (APN may be a promising therapy against fibrotic diseases. In the current study, we determine whether the exogenous globular APN isoform protects against pulmonary fibrosis in PQ-treated mice and human lung fibroblasts, and dissect the responsible underlying mechanisms. BALB/C mice were divided into control group, PQ group, PQ + low-dose APN group, and PQ + high-dose APN group. Mice were sacrificed 3, 7, 14, and 21 days after PQ treatment. We compared pulmonary histopathological changes among different groups on the basis of fibrosis scores, TGF-β1, CTGF and α-SMA pulmonary content via Western blot and real-time quantitative fluorescence-PCR (RT-PCR. Blood levels of MMP-9 and TIMP-1 were determined by ELISA. Human lung fibroblasts WI-38 were divided into control group, PQ group, APN group, and APN receptor (AdipoR 1 small-interfering RNA (siRNA group. Fibroblasts were collected 24, 48, and 72 hours after PQ exposure for assay. Cell viability and apoptosis were determined via Kit-8 (CCK-8 and fluorescein Annexin V-FITC/PI double labeling. The protein and mRNA expression level of collagen type III, AdipoR1, and AdipoR2 were measured by Western blot and RT-PCR. APN treatment significantly decreased the lung fibrosis scores, protein and mRNA expression of pulmonary TGF-β1, CTGF and α-SMA content, and blood MMP-9 and TIMP-1 in a dose-dependent manner (p<0.05. Pretreatment with APN significantly attenuated the reduced cell viability and up-regulated collagen type III expression induced by PQ in lung fibroblasts, (p<0.05. APN pretreatment up-regulated AdipoR1, but not AdipoR2, expression in WI-38 fibroblasts. AdipoR1 siRNA abrogated APN-mediated protective effects in PQ-exposed fibroblasts. Taken together, our data suggests APN protects against PQ-induced pulmonary fibrosis in a

Skeletal muscle secretome in Duchenne muscular dystrophy: a pivotal anti-inflammatory role of adiponectin.

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Lecompte, S; Abou-Samra, M; Boursereau, R; Noel, L; Brichard, S M

2017-07-01

Persistent inflammation exacerbates the progression of Duchenne muscular dystrophy (DMD). The hormone, adiponectin (ApN), which is decreased in the metabolic syndrome, exhibits anti-inflammatory properties on skeletal muscle and alleviates the dystrophic phenotype of mdx mice. Here, we investigate whether ApN retains its anti-inflammatory action in myotubes obtained from DMD patients. We unravel the underlying mechanisms by studying the secretome and the early events of ApN. Primary cultures of myotubes from DMD and control patients were treated or not by ApN after an inflammatory challenge. Myokines secreted in medium were identified by cytokine antibody-arrays and ELISAs. The early events of ApN signaling were assessed by abrogating selected genes. ApN retained its anti-inflammatory properties in both dystrophic and control myotubes. Profiling of secretory products revealed that ApN downregulated the secretion of two pro-inflammatory factors (TNFα and IL-17A), one soluble receptor (sTNFRII), and one chemokine (CCL28) in DMD myotubes, while upregulating IL-6 that exerts some anti-inflammatory effects. These changes were explained by pretranslational mechanisms. Earlier events of the ApN cascade involved AdipoR1, the main receptor for muscle, and the AMPK-SIRT1-PGC-1α axis leading, besides alteration of the myokine profile, to the upregulation of utrophin A (a dystrophin analog). ApN retains its beneficial properties in dystrophic muscles by activating the AdipoR1-AMPK-SIRT1-PGC-1α pathway, thereby inducing a shift in the secretion of downstream myokines toward a less inflammatory profile while upregulating utrophin. ApN, the early events of the cascade and downstream myokines may be therapeutic targets for the management of DMD.

PENGARUH 2,4-D TERHADAP HIPOKOTIL DAN KOTILEDON KEDELAI VARIETAS SLAMET YANG DITUMBUHKAN SECARA IN VITRO

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Iman Budisantoso

2015-02-01

Full Text Available Tujuan yang akan dicapai dalam penelitian ini adalah mengetahui pengaruh 2,4-D terhadap pertumbuhan dan perkembangan hipokotil dan kotiledon kedelai varietas Slamet dalam kultur in vitro. Penelitian dilakukan secara eksperimental dengan rancangan percobaan Rancangan Acak Lengkap (RAL, perlakuan yang dicobakan adalah larutan 2,4-D yang terdiri dari 4 level konsentrasi yaitu 0 mg/L; 20 mg/L; 40 mg/L dan 60 mg/L dan masing-masing perlakuan diulang 4 kali. Parameter perkembangan eksplant yang diamati meliputi prosentase pertumbuhan melalui pembentukan kalus maupun proses embriogenesis, waktu tumbuh kalus, berat basah kalus dan jenis kalus yang terbentuk. Hasil penelitian menunjukkan bahwa eksplant hipokotil maupun kotiledon kedelai varietas Slamet yang ditumbuhkan dalam media MS dengan perlakuan 2,4-D 20-60 mg/L tidak menghasilkan kalus maupun tanaman melalui proses embriogenesis, eksplant berwarna coklat dan mati. Setelah perlakuan konsentrasi hormon diubah menjadi 0, 5, 10 dan 15 mg/L, kalus tumbuh pada eksplant hipokotil dengan perlakuan 2,4-D 5 mg/L, sedangkan eksplant kotiledon kalus tumbuh pada media dengan perlakuan 2,4-D 15 µM.

Adiponectin attenuates angiotensin II-induced vascular smooth muscle cell remodeling through nitric oxide and the RhoA/ROCK pathway.

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Wared eNour-Eldine

2016-04-01

Full Text Available INTRODUCTION: Adiponectin (APN, an adipocytokine, exerts protective effects on cardiac remodeling, while angiotensin II (Ang II induces hypertension and vascular remodeling. The potential protective role of APN on the vasculature during hypertension has not been fully elucidated yet. Here, we evaluate the molecular mechanisms of the protective role of APN in the physiological response of the vascular wall to Ang II.METHODS AND RESULTS: Rat aortic tissues were used to investigate the effect of APN on Ang II-induced vascular remodeling and hypertrophy. We investigated whether nitric oxide (NO, the RhoA/ROCK pathway, actin cytoskeleton remodeling, and reactive oxygen species (ROS mediate the anti-hypertrophic effect of APN. Ang II-induced protein synthesis was attenuated by pre-treatment with APN, NO donor (SNAP, or cGMP. The hypertrophic response to Ang II was associated with a significant increase in RhoA activation and vascular force production, which were prevented by APN and SNAP. NO was also associated with inhibition of Ang II-induced phosphorylation of cofilin. In addition, immunohistochemistry revealed that 24 hr Ang II treatment increased the F- to G-actin ratio, an effect that was inhibited by SNAP. Ang II-induced ROS formation and upregulation of p22phox mRNA expression were inhibited by APN and NO. Both compounds failed to inhibit Nox1 and p47phox expression. CONCLUSIONS: Our results suggest that the anti-hypertrophic effects of APN are due, in part, to NO-dependent inhibition of the RhoA/ROCK pathway and ROS formation.

Capturing reimbursement for advanced practice nurse services in acute and critical care: legal and business considerations.

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Buppert, Carolyn

2005-01-01

Advanced practice nurses (APNs) have been affected positively and negatively by recent changes in the way hospitals are financed. Among these changes are the shift from cost-based reimbursement to a prospective payment system and increased opportunities for billing APN services under the physician payment system. Positive effects include the need for hospitals to decrease the length of stay of hospitalized patients, leading to jobs for APNs who make the hospital course and discharge more efficient. Negative effects include budget shortfalls that lead to layoffs. This article explains the current financial landscape, including phenomena that are impeding the billing of APN services, and recommends adjustments so that the APN role will be on firm financial footing.

Biochemical characteristics and modulation by external and internal factors of aminopeptidase-N activity in the hepatopancreas of a euryhaline burrowing crab.

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Michiels, M S; del Valle, J C; López Mañanes, A A

2015-07-01

Strikingly, in spite of its physiological importance, information about occurrence, biochemical characteristics and mechanisms of regulation of aminopeptidase-N (APN) in the hepatopancreas of intertidal euryhaline crabs is still lacking. In this work, we determined the occurrence, biochemical characteristics, response to environmental salinity and dopamine of APN in the hepatopancreas of the euryhaline crab Neohelice granulata (Dana 1851) from the open mudflat of Mar Chiquita coastal lagoon (Buenos Aires province, Argentina). APN activity was maximal at pH and temperature range of 7.6-9.0 and 37-45 °C, respectively. APN activity exhibited Michaelis-Menten kinetics (apparent Km = 0.19 ± 0.10 mM) (pH 7.6, 37 °C) and appeared to be sensitive to bestatin (I 50 = 15 mM) and EDTA (I 50 = 9 mM). In crabs acclimated to 10 psu (hyper-regulation conditions) and 37 psu (hypo-regulation conditions), APN activity was about 45 and 160% higher, respectively, than in 35 psu (osmoconformation). APN activity in the hepatopancreas was stimulated in vitro (about 137%) by 10(-4) M dopamine. Higher dopamine concentrations produced a similar extent of increase. The responses of APN activity to salinity and dopamine in vitro suggest the role of APN in digestive adjustments upon hyper and hypo-regulatory conditions and its modulation via direct mechanisms on hepatopancreas by dopamine.

Advanced practice nursing in child maltreatment: practice characteristics.

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Hornor, Gail; Herendeen, Pamela

2014-01-01

Child maltreatment is a problem of epidemic proportions in the United States. Pediatric nurse practitioners and other advanced practice nurses (APNs) have been caring for maltreated children for decades, yet to date no comprehensive assessment of their practice characteristics or their clinical and academic contributions to the field has been performed. The purpose of this study is to describe the practice characteristics of APNs who care for maltreated children. A descriptive design was used for this study. Child advocacy centers and children's hospitals were contacted to inquire about employment of child maltreatment APNs in their institution, and contact information for the lead APN was obtained. The Nurse Practitioner Survey was then sent to lead APNs by e-mail. The majority of APNs who work primarily in child maltreatment are pediatric nurse practitioners who work in child advocacy centers. They are providing care to children with physical and/or sexual abuse concerns; however, APNs provide care for children with all types of child maltreatment concerns. APNs play a vital role in the care of abused/neglected children. Their important contributions include not only clinical care but also the provision of clinical and didactic education to other professionals, parents, and the public. Research and publication are also essential to their role. Copyright © 2014 National Association of Pediatric Nurse Practitioners. Published by Mosby, Inc. All rights reserved.

The Role of the Advanced Practice Nurse in Geriatric Oncology Care.

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Morgan, Brianna; Tarbi, Elise

2016-02-01

To describe how the Advanced Practice Nurse (APN) is uniquely suited to meet the needs of older adults throughout the continuum of cancer, to explore the progress that APNs have made in gero-oncology care, and make suggestions for future directions. Google Scholar, PubMed, and CINAHL. Search terms included: "gero-oncology," "geriatric oncology," "Advanced Practice Nurse," "Nurse Practitioner," "older adult," "elderly," and "cancer." Over the last decade, APNs have made advances in caring for older adults with cancer by playing a role in prevention, screening, and diagnosis; through evidence-based gero-oncology care during cancer treatment; and in designing tailored survivorship care models. APNs must combat ageism in treatment choice for older adults, standardize comprehensive geriatric assessments, and focus on providing person-centered care, specifically during care transitions. APNs are well-positioned to help understand the complex relationship between risk factors, geriatric syndromes, and frailty and translate research into practice. Palliative care must expand beyond specialty providers and shift toward APNs with a focus on early advanced care planning. Finally, APNs should continue to establish multidisciplinary survivorship models across care settings, with a focus on primary care. Copyright © 2015 Elsevier Inc. All rights reserved.

Building to Make a Difference: Advanced Practice Nurses' Experience of Power.

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Schoales, Catherine A; Bourbonnais, Frances Fothergill; Rashotte, Judy

2018-02-01

Power is necessary for nurses to affect change in patient care and to move the nursing profession forward. Despite the evolving body of nursing research on power, there have been no studies that have investigated the nature of advanced practice nurses' (APNs') power. The purpose of this study was to explore the APNs' lived experience of power. Interpretive phenomenology guided the method and analysis. Eight APNs employed in a single Canadian tertiary care teaching health-care organization engaged in in-depth interviews. The overarching theme, building to make a difference, reflected the APNs' perception of power in their practice, which involved a passion to facilitate change in practice to improve patient care. Building to make a difference involved three themes: building on, building with, and building for. The APNs experienced more power-a process they described as power creep-when they used soft power that was shared with others to affect positive change in health care. These findings contribute to our understanding of how power is perceived and manifested in the APN role, thus further enabling organizations to create working conditions to support the APNs' endeavors to empower others.

Mechanisms for the inversion of chirality: Global reaction route mapping of stereochemical pathways in a probable chiral extraterrestrial molecule, 2-aminopropionitrile

International Nuclear Information System (INIS)

Kaur, Ramanpreet; Vikas

2015-01-01

2-Aminopropionitrile (APN), a probable candidate as a chiral astrophysical molecule, is a precursor to amino-acid alanine. Stereochemical pathways in 2-APN are explored using Global Reaction Route Mapping (GRRM) method employing high-level quantum-mechanical computations. Besides predicting the conventional mechanism for chiral inversion that proceeds through an achiral intermediate, a counterintuitive flipping mechanism is revealed for 2-APN through chiral intermediates explored using the GRRM. The feasibility of the proposed stereochemical pathways, in terms of the Gibbs free-energy change, is analyzed at the temperature conditions akin to the interstellar medium. Notably, the stereoinversion in 2-APN is observed to be more feasible than the dissociation of 2-APN and intermediates involved along the stereochemical pathways, and the flipping barrier is observed to be as low as 3.68 kJ/mol along one of the pathways. The pathways proposed for the inversion of chirality in 2-APN may provide significant insight into the extraterrestrial origin of life

Association of procalcitonin with acute pyelonephritis and renal scars in pediatric UTI.

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Leroy, Sandrine; Fernandez-Lopez, Anna; Nikfar, Roya; Romanello, Carla; Bouissou, François; Gervaix, Alain; Gurgoze, Metin K; Bressan, Silvia; Smolkin, Vladislav; Tuerlinckx, David; Stefanidis, Constantinos J; Vaos, Georgos; Leblond, Pierre; Gungor, Firat; Gendrel, Dominique; Chalumeau, Martin

2013-05-01

Urinary tract infections (UTIs) are common childhood bacterial infections that may involve renal parenchymal infection (acute pyelonephritis [APN]) followed by late scarring. Prompt, high-quality diagnosis of APN and later identification of children with scarring are important for preventing future complications. Examination via dimercaptosuccinic acid scanning is the current clinical gold standard but is not routinely performed. A more accessible assay could therefore prove useful. Our goal was to study procalcitonin as a predictor for both APN and scarring in children with UTI. A systematic review and meta-analysis of individual patient data were performed; all data were gathered from children with UTIs who had undergone both procalcitonin measurement and dimercaptosuccinic acid scanning. A total of 1011 patients (APN in 60.6%, late scarring in 25.7%) were included from 18 studies. Procalcitonin as a continuous, class, and binary variable was associated with APN and scarring (P children who had APN during the early stages of UTI, as well as those with late scarring.

Uji Daya Hambat Ekstrak Buah Belimbing Manis (Averrhoa carambola terhadap Pertumbuhan Bakteri Streptococcus pneumoniae secara In Vitro

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Rita Risandi

2016-09-01

Full Text Available AbstrakBuah belimbing manis (Averrhoa carambola merupakan salah satu tanaman Indonesia yang diyakini memiliki khasiat obat. Salah satu manfaat yang dapat diambil dari sari buah belimbing manis (Averrhoa carambola adalah dapat mengobati radang tenggorokan. Radang tenggorokan merupakan salah satu infeksi yang disebabkan oleh bakteri Streptococcus pneumoniae. Tujuan penelitian ini adalah menentukan daya hambat ekstrak buah belimbing manis (Averrhoa carambola terhadap pertumbuhan bakteri Streptococcus pneumoniae  secara in vitro. Metode studi ini ialah eksperimental dengan desain postest only control group design yang dilakukan di Laboratorium Biota Sumatera Universitas Andalas dan Laboratorium Mikrobiologi Fakultas Kedokteran Universitas Andalas dari Agustus sampai Oktober 2014. Hasil penelitian menunjukkan bahwa ekstrak buah belimbing manis (Averrhoa carambola dengan konsentrasi yaitu 5%, 10%, 15% dan 20% tidak memiliki daya hambat terhadap pertumbuhan bakteri Streptococcus pneumoniae.  Hal ini terbukti karena tidak terbentuk zona hambat pada agar darah dan tidak terdapat pengaruh lama kontak ekstrak buah belimbing manis (Averrhoa carambola  terhadap pertumbuhan bakteri Streptococcus pneumoniae secara in vitro. Ekstrak buah belimbing manis tidak memiliki efek antibakteri terhadap pertumbuhan bakteri Streptococcus pneumoniae.Kata kunci: ekstrak buah belimbing manis, Streptococcus pneumoniae, daya hambat Abstract             Star fruit (Averrhoa carambola is a Indonesian plant that is believed to have medicinal properties. One of the benefits that can be drawn from the juice of star fruit (Averrhoa carambola is the ability to treat strep throat. Strep throat is a bacterial infection caused by Streptococcus pneumoniae. The objective of this study was to determine the inhibitory extract of star fruit (Averrhoa carambola on the growth of the bacterium Streptococcus pneumoniae in vitro. This was an experimental  research  with design

Uji Efektivitas Pestisida terhadap Beberapa Patogen Penyebab Penyakit Penting pada Buah Naga (Hylocereus sp. secara In Vitro

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Ani Widiastuti

2011-12-01

Full Text Available Problem caused by pathogen in Dragon Fruit (Hylocereus sp. cultivation became very important because it decreased significantly the quantity and quality of the fruit production. This study aims to determine the effectiveness of some pesticides against pathogens that cause diseases of dragon fruit in several plantations in the DIY (Sleman and Kulon Progo and Central Java (Magelang and Batang. Test of fungicide effectiveness was done in vitro on PDA medium (potato dextrose agar by poisoned food technique. The fungicides were mancozeb 80 %, methyl tiofanat 70 %, copper hydroxide 80 %, chlorotalonil 75 %, mancozeb 64 % + metalaxyl 4 %, mancozeb karbendazim 73.8 % + 6.8 %,benomyl 50 % at a concentration of 1g/L. The bactericides used were streptomycin sulfate 20 % and oxytetracycline 150 AL with each concentration of 1 g/L and 1 mL /L. The results showed that benomyl 50 % was the most effective fungicide to suppress the growth of Fusarium sp. (brown spot, Colletotrichum sp. (anthracnose and Pestalotiopsis sp. (scab, followed by mancozeb 73.8 % +karbendazim 6.8 % and 73.8 % mancozeb. Bactericide which was able to suppress the growth of Erwinia sp. (stem rot was streptomycin sulfate 20 %.   Gangguan patogen pada buah naga (Hylocereus sp. saat ini menjadi masalah penting karena secara signifikan menurunkan kuantitas dan kualitas hasil panen. Penelitian ini bertujuan untuk mengetahui keefektivan beberapa pestisida terhadap patogen penyebab penyakit-penyakit penting pada tanaman buah naga yang ditanaman pada beberapa sentra pertanaman di Propinsi DIY (Sleman dan Kulon Progo dan Jawa Tengah (Magelang dan Batang. Uji keefektivan pestisida dilakukan secara in vitro pada medium PDA (potato dextrose agar dengan metode teknik makanan beracun (poisoned food technique. Fungisida yang dipergunakan adalah mankozeb 80%, tiofanat metil 70%, tembaga hidroksida 80%, klorotalonil 75%, mankozeb 64% + metalaksil 4%, mankozeb 73,8% + karbendazim 6,8%, benomil 50% dengan

Efek Antibakteri Ekstrak Daun Mimba (Azadirachta indica A. Juss terhadap Bakteri Vibrio algynoliticus Secara In Vitro

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Uli Ayini

2014-03-01

Full Text Available Budidaya udang windu di Indonesia telah berkembang pesat. Salah satu kendala budidaya udang adalah penyakit Vibriosis yang disebabkan oleh bakteri Vibrio algynoliticus. Tujuan penelitian ini adalah untuk mengetahui efek antibakeri ekstrak daun mimba terhadap bakteri Vibrio algynoliticus. Penelitian ini menggunakan metode dilusi untuk mengetahui efek antibakteri ekstrak daun mimba terhadap bakteri Vibrio algynoliticus secara in vitro. Konsentrasi ekstrak yang digunakan (% yaitu: 0; 2,5; 5; 7,5; 10; 12,5 dan sebagai kontrol terdiri dari kontrol positif, dan kontrol negatif. Pengumpulan data untuk menentukan MIC (Minimum Inhibitory Concentration dilakukan dengan membandingkan kejernihan kultur di medium TSB 2% pada berbagai konsentrasi yang berbeda, dengan kontrol positif dan kontrol negatif. Penentuan MBC (Minimum Bacterisidal Concentration dilakukan dengan melihat ada tidaknya dan jumlah koloni bakteri Vibrio alginolyticus yang muncul pada medium subkultur TSA 2% setelah inkubasi 24 jam. Hasil penelitian menunjukkan nilai MIC yaitu konsentrasi 5%, hal ini ditunjukkan dengan tabung yang mulai jernih. Nilai MBC ekstrak daun mimba terhadap bakteri Vibrio alginolyticus adalah konsentrasi 12,5% ditandai dengan sudah tidak munculnya  koloni bakteri Vibrio alginolyticus. Berdasarkan penelitian ini dapat disimpulkan bahwa ekstrak daun mimba dapat memberikan efek antibakteri terhadap bakteri Vibrio alginolyticus secara in vitro.Tiger shrimp cultivation in Indonesia has been growing rapidly. The main obstacle is the shrimp farming vibriosis disease caused by the bacterium Vibrio algynoliticus. The aim of this research was to determine the effects of neem leaf extract antibakeri against Vibrio algynoliticus. This study used a dilution method to determine the antibacterial effect of neem leaf extract against Vibrio algynoliticus bacteria in vitro. The concentration of the extract used (%: 0; 2.5; 5; 7.5; 10; 12.5 and as a control consisting of a positive

Porcine aminopeptidase N binds to F4+ enterotoxigenic Escherichia coli fimbriae.

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Xia, Pengpeng; Wang, Yiting; Zhu, Congrui; Zou, Yajie; Yang, Ying; Liu, Wei; Hardwidge, Philip R; Zhu, Guoqiang

2016-02-09

F4(+) enterotoxigenic Escherichia coli (ETEC) strains cause diarrheal disease in neonatal and post-weaned piglets. Several different host receptors for F4 fimbriae have been described, with porcine aminopeptidase N (APN) reported most recently. The FaeG subunit is essential for the binding of the three F4 variants to host cells. Here we show in both yeast two-hybrid and pulldown assays that APN binds directly to FaeG, the major subunit of F4 fimbriae, from three serotypes of F4(+) ETEC. Modulating APN gene expression in IPEC-J2 cells affected ETEC adherence. Antibodies raised against APN or F4 fimbriae both reduced ETEC adherence. Thus, APN mediates the attachment of F4(+) E. coli to intestinal epithelial cells.

Reduction Levels and the Effects of High-Molecular-Weight Adiponectin via AMPK/eNOS in Chinese Type 2 Diabetes.

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Lian, K; Guo, X; Huang, Q; Tan, Z; Xia, C; Wang, R; Yi, F; Li, W; Liu, J; Li, Y; Guo, S; Wang, H; Ji, Q; Tao, L

2016-10-01

Aim: This study was to investigate the change of high-molecula-weight (HMW) adiponectin (APN) isoform, the association between type 2 diabetes mellitus (T2DM) and HMW APN isoform, the variation of Disulfide-bond A oxidoreductase-like protein (DsbA-L), the effect of HMW APN isoform on AMP-dependent protein kinase (AMPK) and endothelial nitric oxide synthase (eNOS) in Chinese T2DM. Method: 169 patients aged at (48.7±9.4) years and 107 healthy control subjects aged at (42.6±7.8) years took part in this study. Anthropometric measures of the characters were assayed and different APN isoforms, DsbA-L, AMPK and eNOS levels were determined. Results: Ln(sRAGE) and Ln(Adiponectin) were significantly lower and significantly higher for the other characteristics in T2DM. Ln(Adiponectin) was negatively and significantly correlated with WHR, Ln(triglycerides), fasting plasma glucose, HbA1c (%) in control subjects and T2DM patients. Plasma and adipose tissue total APN and HMW APN were significantly reduced in newly diagnosed T2DM patients. DsbA-L was markedly down-regulated in diabetic adipose tissue. HMW APN caused significant decreases in AMPK and eNOS phosphorylation levels of human umbilical vein endothelial cells (HUVECs). Conclusions: Our results demonstrated that total APN levels was closely related to the risk of T2DM and HMW APN reduction was involved in the diabetic vascular AMPK/eNOS signal pathway. The findings will provide insight into novel therapeutic approaches for reducing the elevated cardiovascular risk associated with T2DM. © Georg Thieme Verlag KG Stuttgart · New York.

Impact of recombinant globular adiponectin on early warm ischemia-reperfusion injury in rat bile duct after liver transplantation.

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Xia, Yang; Gong, Jian-Ping

2014-09-19

Adiponectin (APN) is an adipocyte protein with anti-diabetic properties, which has been recently revealed to have anti-inflammatory activity in organ ischemia- reperfusion injury (IRI). However, little is known about its function in bile duct IRI after liver transplantation. Therefore, we investigated whether APN affects early warm IRI in rat bile duct using a liver autologous transplantation model. In our study, rats were randomly divided into three experimental groups: a sham group, a IRI group, and a APN group. The serum enzyme levels and BDISS scores of bile duct histology associated with bile duct injury, decreased after administration of APN. Subsequently, the expression of proinflammatory cytokines, such as tumor necrosis factor(TNF-α),.interleukin-6(IL-6) and myeloperoxidase (MPO) decreased. Furthermore, pretreatment with APN suppressed the activation of nuclear factor-kappa B (NF-κB) (p65), a transcription factor involved in inflammatory reactions, compared to other two groups. Administration of APN also downregulated the expression of Fas protein and attenuated caspase-3 activity to decrease bile duct apoptosis. Our results illustrate that APN protects the rat bile duct against early warm IRI by suppressing the inflammatory response and hepatocyte apoptosis, and NF-κB (p65) plays an important role in this process.

Advanced Practice Nursing: A Strategy for Achieving Universal Health Coverage and Universal Access to Health

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Denise Bryant-Lukosius

Full Text Available ABSTRACT Objective: to examine advanced practice nursing (APN roles internationally to inform role development in Latin America and the Caribbean to support universal health coverage and universal access to health. Method: we examined literature related to APN roles, their global deployment, and APN effectiveness in relation to universal health coverage and access to health. Results: given evidence of their effectiveness in many countries, APN roles are ideally suited as part of a primary health care workforce strategy in Latin America to enhance universal health coverage and access to health. Brazil, Chile, Colombia, and Mexico are well positioned to build this workforce. Role implementation barriers include lack of role clarity, legislation/regulation, education, funding, and physician resistance. Strong nursing leadership to align APN roles with policy priorities, and to work in partnership with primary care providers and policy makers is needed for successful role implementation. Conclusions: given the diversity of contexts across nations, it is important to systematically assess country and population health needs to introduce the most appropriate complement and mix of APN roles and inform implementation. Successful APN role introduction in Latin America and the Caribbean could provide a roadmap for similar roles in other low/middle income countries.

Holistic health care: Patients' experiences of health care provided by an Advanced Practice Nurse.

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Eriksson, Irene; Lindblad, Monica; Möller, Ulrika; Gillsjö, Catharina

2018-02-01

Advanced Practice Nurse (APN) is a fairly new role in the Swedish health care system. To describe patients' experiences of health care provided by an APN in primary health care. An inductive, descriptive qualitative approach with qualitative open-ended interviews was chosen to obtain descriptions from 10 participants regarding their experiences of health care provided by an APN. The data were collected during the spring 2012, and a qualitative approach was used for analyze. The APNs had knowledge and skills to provide safe and secure individual and holistic health care with high quality, and a respectful and flexible approach. The APNs conveyed trust and safety and provided health care that satisfied the patients' needs of accessibility and appropriateness in level of care. The APNs way of providing health care and promoting health seems beneficial in many ways for the patients. The individual and holistic approach that characterizes the health care provided by the APNs is a key aspect in the prevailing change of health care practice. The transfer of care and the increasing number of older adults, often with a variety of complex health problems, call for development of the new role in this context. © 2017 The Authors. International Journal of Nursing Practice Published by John Wiley & Sons Australia, Ltd.

Adiponectin protects palmitic acid induced endothelial inflammation and insulin resistance via regulating ROS/IKKβ pathways.

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Zhao, Wenwen; Wu, Chuanhong; Li, Shaojing; Chen, Xiuping

2016-12-01

Endothelial inflammation and insulin resistance (IR) has been closely associated with endothelial dysfunction. Adiponectin (APN), an adipocyte-secreted hormone from adipose tissues, showed cardioprotective effects. Here, the protective effect of APN on palmitic acid (PA)-induced endothelial inflammation and IR was investigated. Cultured human umbilical vein endothelial cells (HUVECs) were treated with PA without or without APN pretreatment. The expression of inflammatory cytokines TNF-α, IL-6, adhesion molecule ICAM-1 were determined by western blotting, ELISA, and real-time PCR. The protein expression and protein-protein interaction were determined by western blotting and immunoprecipitation. The intracellular reactive oxygen species (ROS) and nitric oxide (NO) production were monitored with fluorescence probes. PA-induced secretion of TNF-α, IL-6, and expression of ICAM-1 at protein and mRNA levels, which was significantly inhibited by APN. PA treatment caused increase of ROS generation, NOX2, p-IKKβ, p-IκBα, p-p65 expression, and p-IκBα-IKKβ interaction, which were all partly reversed by APN. ROS scavenger N-acetylcysteine (NAC) and NF-κB inhibitor PDTC showed similar effect on PA-induced secretion of TNF-α, IL-6, and expression of ICAM-1. Furthermore, APN and NAC pretreatment restored PA-induced increase of p-IRS-1(S307), decrease of p-IRS-1(Tyr). In addition, insulin-triggered expression of p-IRS-1(Tyr), p-PI3K, p-AKT, p-eNOS and NO generation were inhibited by PA, which were also restored by both APN and NAC. These results suggested that APN ameliorated endothelial inflammation and IR through ROS/IKKβ pathway. This study shed new insights into the mechanisms of APN's cardiovascular protective effect. Copyright © 2016 Elsevier Ltd. All rights reserved.

Effect of adiponectin deficiency on intestinal damage and hematopoietic responses of mice exposed to gamma radiation

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Ponemone, Venkatesh; Fayad, Raja; Gove, Melissa E.; Pini, Maria [Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612 (United States); Fantuzzi, Giamila, E-mail: giamila@uic.edu [Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612 (United States)

2010-08-07

Adiponectin (APN) is an adipose tissue-derived cytokine that regulates insulin sensitivity and inflammation. It is also involved in modulation of cell proliferation by binding to various growth factors. Based on its known effects in modulating cell proliferation and oxidative stress, APN may potentially be involved in regulating tissue damage and repair following irradiation. Adiponectin KO mice and their WT littermates were exposed to a single whole-body dose of 3 or 6 Gy gamma radiation. Radiation-induced alterations were studied in jejunum, blood, bone marrow and thymus at days 1 and 5 post-irradiation and compared with sham-irradiated groups. In WT mice, irradiation did not significantly alter serum APN levels while inducing a significant decrease in serum leptin. Irradiation caused a significant reduction in thymocyte cellularity, with concomitant decrease in CD4{sup +}, CD8{sup +} and CD4{sup +}CD8{sup +} T cell populations, with no significant differences between WT and APN KO mice. Irradiation resulted in a significantly higher increase in the frequency of micronucleated reticulocytes in the blood of APN KO compared with WT mice, whereas frequency of micronucleated normochromatic erythrocytes in the bone marrow at day 5 was significantly higher in WT compared with APN KO mice. Finally, irradiation induced similar alterations in villus height and crypt cell proliferation in the jejunum of WT and APN KO mice. Jejunum explants from sham-irradiated APN KO mice produced higher levels of IL-6 compared with tissue from WT animals, but the difference was no longer apparent following irradiation. Our data indicate that APN deficiency does not play a significant role in modulating radiation-induced gastrointestinal injury in mice, while it may participate in regulation of damage to the hematopoietic system.

Intriguing interplay between feline infectious peritonitis virus and its receptors during entry in primary feline monocytes.

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Van Hamme, Evelien; Desmarets, Lowiese; Dewerchin, Hannah L; Nauwynck, Hans J

2011-09-01

Two potential receptors have been described for the feline infectious peritonitis virus (FIPV): feline aminopeptidase N (fAPN) and feline dendritic cell-specific intercellular adhesion molecule grabbing non-integrin (fDC-SIGN). In cell lines, fAPN serves as a receptor for serotype II, but not for serotype I FIPV. The role of fAPN in infection of in vivo target cells, monocytes, is not yet confirmed. Both serotype I and II FIPVs use fDC-SIGN for infection of monocyte-derived cells but how is not known. In this study, the role of fAPN and fDC-SIGN was studied at different stages in FIPV infection of monocytes. First, the effects of blocking the potential receptor(s) were studied for the processes of attachment and infection. Secondly, the level of co-localization of FIPV and the receptors was determined. It was found that FIPV I binding and infection were not affected by blocking fAPN while blocking fDC-SIGN reduced FIPV I binding to 36% and practically completely inhibited infection. Accordingly, 66% of bound FIPV I particles co-localized with fDC-SIGN. Blocking fAPN reduced FIPV II binding by 53% and infection by 80%. Further, 60% of bound FIPV II co-localized with fAPN. fDC-SIGN was not involved in FIPV II binding but infection was reduced with 64% when fDC-SIGN was blocked. In conclusion, FIPV I infection of monocytes depends on fDC-SIGN. Most FIPV I particles already interact with fDC-SIGN at the plasma membrane. For FIPV II, both fAPN and fDC-SIGN are involved in infection with only fAPN playing a receptor role at the plasma membrane. Copyright © 2011 Elsevier B.V. All rights reserved.

Effect of adiponectin deficiency on intestinal damage and hematopoietic responses of mice exposed to gamma radiation

International Nuclear Information System (INIS)

Ponemone, Venkatesh; Fayad, Raja; Gove, Melissa E.; Pini, Maria; Fantuzzi, Giamila

2010-01-01

Adiponectin (APN) is an adipose tissue-derived cytokine that regulates insulin sensitivity and inflammation. It is also involved in modulation of cell proliferation by binding to various growth factors. Based on its known effects in modulating cell proliferation and oxidative stress, APN may potentially be involved in regulating tissue damage and repair following irradiation. Adiponectin KO mice and their WT littermates were exposed to a single whole-body dose of 3 or 6 Gy gamma radiation. Radiation-induced alterations were studied in jejunum, blood, bone marrow and thymus at days 1 and 5 post-irradiation and compared with sham-irradiated groups. In WT mice, irradiation did not significantly alter serum APN levels while inducing a significant decrease in serum leptin. Irradiation caused a significant reduction in thymocyte cellularity, with concomitant decrease in CD4 + , CD8 + and CD4 + CD8 + T cell populations, with no significant differences between WT and APN KO mice. Irradiation resulted in a significantly higher increase in the frequency of micronucleated reticulocytes in the blood of APN KO compared with WT mice, whereas frequency of micronucleated normochromatic erythrocytes in the bone marrow at day 5 was significantly higher in WT compared with APN KO mice. Finally, irradiation induced similar alterations in villus height and crypt cell proliferation in the jejunum of WT and APN KO mice. Jejunum explants from sham-irradiated APN KO mice produced higher levels of IL-6 compared with tissue from WT animals, but the difference was no longer apparent following irradiation. Our data indicate that APN deficiency does not play a significant role in modulating radiation-induced gastrointestinal injury in mice, while it may participate in regulation of damage to the hematopoietic system.

Aktivitas Vermisidal dan Ovisidal Daun Biduri (Calotropis Spp. Terhadap Cacing Fasciola Gigantica Secara In Vitro

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Gilang Kala Maulana

2015-08-01

Full Text Available Penelitian ini bertujuan untuk mengetahui aktivitas vermisidal dan ovisidal daun Biduri (Calotropis spp. terhadap cacing F. gigantica. Sampel yang digunakan dalam penelitian ini yaitu telur dan cacing F. gigantica yang diperoleh dari Rumah Potong Hewan Pesanggaran dan daun biduri diambil dari pantai Sanur, Denpasar Bali. Konsentrasi daun biduri dibuat menggunakan daun segar yang dihancurkan dan kemudian dicampurkan dengan cairan empedu untuk vermisidal dan aquades untuk ovisidal. Konsentrasi yang digunakan dalam penelitian ini yaitu 2,5%, 5%, 7,5%, dan 10%. Pengujian dilakukan secara in vitro dengan menggunakan lima perlakuan dan empat kali ulangan. Pengamatan vermisidal dilakukan setiap 30 menit sedangkan untuk ovisidal dilakukan pada hari ke-21 dan ke-28. Hasil dari penelitian didapatkan konsentrasi daun biduri (2,5%, 5%, 7,5%, dan 10% pada masing-masing kelompok perlakuan memiliki pengaruh vermisidal, tidak berbeda nyata (P>0.05 terhadap satu dengan yang lainnya. Efek ovisidal pada hari ke-21 dan ke-28 didapatkan adanya pengaruh yang nyata (P<0.05 terhadap daya hambat tetas telur cacing F. gigantica. Disimpulkan bahwa daun biduri memiliki aktivitas vermisidal dan ovisidal terhadap cacing dan telur F. gigantica. Konsentrasi yang paling efektif untuk vermisidal dan ovisidal terhadap cacing F. gigantica adalah 5%.

Plasma neutrophil gelatinase-associated lipocalin: a marker of acute pyelonephritis in children.

Science.gov (United States)

Kim, Byung Kwan; Yim, Hyung Eun; Yoo, Kee Hwan

2017-03-01

This study was designed to compare the diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin (NGAL) with procalcitonin (PCT), C-reactive protein (CRP), and white blood cells (WBCs) for predicting acute pyelonephritis (APN) in children with febrile urinary tract infections (UTIs). In total, 138 children with febrile UTIs (APN 59, lower UTI 79) were reviewed retrospectively. Levels of NGAL, PCT, CRP, and WBCs in blood were measured on admission. The diagnostic accuracy of the biomarkers was investigated. Independent predictors of APN were identified by multivariate logistic regression analysis. Receiver operating curve (ROC) analyses showed good diagnostic profiles of NGAL, PCT, CRP, and WBCs for identifying APN [area under the curve (AUC) 0.893, 0.855, 0.879, and 0.654, respectively]. However, multivariate analysis revealed only plasma NGAL level was an independent predictor of APN (P = 0.006). At the best cutoff values of all examined biomarkers for identifying APN, sensitivity (86 %), specificity (85 %), positive predictive value (81 %), and negative predictive value (89 %) of plasma NGAL levels were the highest. The optimal NGAL cutoff value was 117 ng/ml. The positive likelihood ratio [odds ratio (OR) 5.69, 95 % confidence interval (CI) 3.56-8.78], and negative likelihood ratio (OR 0.16, 95 % CI 0.08-0.29) of plasma NGAL for APN diagnosis also showed it seemed to be more accurate than serum PCT, CRP, and WBCs. Plasma NGAL can be more useful than serum PCT, CRP, and WBC levels for identifying APN in children with febrile UTIs.

PELACAKAN KEMBALI KONTROL-KONTROL OBYEK PADA PENAMBAHAN OBYEK SECARA DINAMIS BERBASIS VISUAL BASIC STUDI KASUS ANALISA HIRARKI TUGAS

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Dwi Sunaryono

2003-01-01

Full Text Available v\\:* {behavior:url(#default#VML;} o\\:* {behavior:url(#default#VML;} w\\:* {behavior:url(#default#VML;} .shape {behavior:url(#default#VML;} Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Pembentukan HTA(Hierarchical Task Analysis pada dunia nyata dapat menentukan urutan tugas yang harus diselesaikan dan beberapa jalan / cara yang dapat dicapai baik secara horizontal maupun vertikal. Pendekatan HTA dapat dipetakan kedalam logika komputer berupa alur tugas dari setiap obyek di komputer yang membentuk hirarki tugas dari masing-masing obyek yang akan dikerjakan oleh komputer. Pekerjaan ini mirip dengan pembuatan strategi dan kemudian hasilnya terlihat secara visual, sehingga memungkinkan terjadinya refresh engineering tanpa harus melakukan kompilasi program. Pekerjaan tersebut terdiri dari : pembuatan aturan untuk masing-masing obyek dan cara penerjemahannya (interpreter. Setiap obyek yang dibuat diberi urutan tugas yang berkaitan dengan event, property dan method dari suatu obyek yang akan dikerjakan. Perencanaan obyek tersebut tersimpan ke dalam database sehingga untuk pengerjaan akan merefer ke aturan yang ada di database tersebut yang kemudian di load ke memory sama halnya ketika suatu obyek di instanciate.Kontrol-kontrol obyek setelah terbentuk (instance

ANALISIS DIAZINON SECARA DIFERENSIAL PULSA VOLTAMETRI DIBANDINGKAN DENGAN KROMATOGRAFI (Diazinon Analysis with Differential Pulse Voltametry Compared to Chromatography

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Pirim Setiarso

2011-07-01

Full Text Available ABSTRAK Telah dilakukan penelitian penentuan diazinon dari sampel tanah pertanian di beberapa kecamatan Kabupaten Nganjuk Jawa Timur menggunakan elektroda kerja tembaga amalgam padat (CuSAE secara diferensial pulsa voltametri (DPV dibandingkan dengan metode kromatografi. 100 g sampel tanah pertanian yang dihaluskan dengan ukuran 100 mesh diekstraksi menggunakan aseton. Ekstraksi dilakukan menggunakan ekstraktror soxhlet dengan 10 kali sirkulasi. Hasil ekstraksi sebagian ditambahkan surfaktan SDS untuk dianalisis secara voltametri menggunakan elektroda CuSAE dan sebagian dianalisis menggunakan kromatografi cair kinerja tinggi (HPLC. Analisis voltametri dilakukan pada pH 3 dengan elektrolit pendukung CaCl 2 menggunakan standar adisi, sedangkan analisis dengan HPLC menggunakan grafik standar. Berdasarkan data voltamogram dan kromatogram yang telah diolah dengan program origin 7.0 menghasilkan perolehan kembali rata-rata diazinon (97.40 ± 1.02 % pada voltametri dan (100.98 ± 7.10 % pada HPLC. Analisis diazinon kedua metode dibandingkan dengan uji t (t hitung = 0.4785 < t tabel = 2.31 sehingga tidak ada perbedaan hasil antara metode voltametri dan HPLC. ABSTRACT The research has been done for determination of diazinon in agricultural soil samples from several districts n Nganjuk, East Java . Solid copper amalgam (CuSAE used  as a working electrode using differential ulse voltammetry (DPV compared with chromatographic method. Around 100 g sample of agricultural soil ith a size 100 mesh was extracted using 100 ml acetone. The extraction was done using extractor oxhlet with 10 times the circulation. A part of the extraction  yield  was  added SDS surfactant for analysis by DPV,  and another part analyzed  by using high performance liquid chromatography (HPLC. Voltammetric analysis carried out at pH 3 with CaCl2 as a supporting electrolyte   using standard addition method, while the analysis by HPLC using calibration curve (standard

AFETR Instrumentation Handbook

Science.gov (United States)

1971-09-01

90 TELEMETRY 0 U- a. 00 m 00~0 0L 0- uiu o of U- u 0 > IL a__3c 00f z X I- I-- 00 ( Sdg )l 08L) J:)I?j Oi to- zn M 00 LuU co 0 he o~~0 I-i zw~~~- ~ca LL...ARN-6 DFA-70 4. APN-70 LORAN x 5. N-l Compass System X X 6. True Air Speed Ind Sys X X 7. APN-59 SEarch Radar X X 8. Doppler Nav Radar APN-82 APN-147 9

Framework for Evaluating the Impact of Advanced Practice Nursing Roles.

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Bryant-Lukosius, Denise; Spichiger, Elisabeth; Martin, Jacqueline; Stoll, Hansruedi; Kellerhals, Sabine Degen; Fliedner, Monica; Grossmann, Florian; Henry, Morag; Herrmann, Luzia; Koller, Antje; Schwendimann, René; Ulrich, Anja; Weibel, Lukas; Callens, Betty; De Geest, Sabina

2016-03-01

To address the gap in evidence-based information required to support the development of advanced practice nursing (APN) roles in Switzerland, stakeholders identified the need for guidance to generate strategic evaluation data. This article describes an evaluation framework developed to inform decisions about the effective utilization of APN roles across the country. A participatory approach was used by an international group of stakeholders. Published literature and an evidenced-based framework for introducing APN roles were analyzed and applied to define the purpose, target audiences, and essential elements of the evaluation framework. Through subsequent meetings and review by an expert panel, the framework was developed and refined. A framework to evaluate different types of APN roles as they evolve to meet dynamic population health, practice setting, and health system needs was created. It includes a matrix of key concepts to guide evaluations across three stages of APN role development: introduction, implementation, and long-term sustainability. For each stage, evaluation objectives and questions examining APN role structures, processes, and outcomes from different perspectives (e.g., patients, providers, managers, policy-makers) were identified. A practical, robust framework based on well-established evaluation concepts and current understanding of APN roles can be used to conduct systematic evaluations. The evaluation framework is sufficiently generic to allow application in developed countries globally, both for evaluation as well as research purposes. © 2016 Sigma Theta Tau International.

Gender differences in the relationships among obesity, adiponectin and brachial artery distensibility in adolescents and young adults.

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Urbina, E M; Khoury, P; Martin, L J; D'Alessio, D; Dolan, L M

2009-10-01

Obesity-related cardiovascular diseases (CVDs) are a major cause of cardiovascular (CV) mortality. Obesity-related reduction in vascular protective adipose-derived proteins, such as adiponectin (APN), has an important role. We compared brachial artery distensibility (BrachD) with APN, the level of adiposity and other CV risk factors (CVRFs) in 431 post-pubertal subjects (mean 17.9 years). Gender differences in average values were examined by t-tests. Correlations among BrachD, obesity and other CVRFs were examined. Regression analysis was performed to determine whether APN provided an independent contribution to BrachD, while controlling for obesity and other CVRFs. Male subjects had lower BrachD (5.72+/-1.37 vs 6.45+/-1.60% change per mm Hg, Pgender, APN*gender and BMI z-score predicted BrachD (r(2)=0.305). On the basis of gender difference, only BMI z-score was significant for male subjects (r(2)=0.080), whereas APN and BMI z-score contributed for female subjects (r(2)=0.242, all Pobesity in both male and female subjects. In female subjects, APN exerts an additional independent effect even after adjusting for blood pressure (BP), lipid levels and insulin. Differences in the effect of the APN-adiposity relationship on obesity-related vascular disease may be one reason for gender differences in the development and progression of atherosclerosis.

Caring in telehealth.

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Varghese, Shainy B; Phillips, Carolyn A

2009-12-01

The overall goal of this study was to explore and describe the perceptions of advanced practice nurses (APNs) about caring while providing primary care using telehealth technology. This study used naturalistic inquiry methodology to elicit the subjective perceptions and reflections of a sample of APNs about how they convey caring in the context of telehealth. Thirteen APNs, selected by purposive and snowball sampling, participated in the study. The data for the study consisted of interviews conducted by e-mail using a semistructured interview guide. Data analysis used the constant comparison method; rigor and trustworthiness of the study procedures were established using the criteria of credibility, confirmability, dependability, and transferability. The findings of this study revealed that the APNs conveyed caring to their telehealth patients by (1) being with them, (2) personifying the images, and (3) possessing certain attributes. The major constructs that emerged from the data together formed a model of how APNs conveyed caring in telehealth. The findings provide insights and increase the understanding of how caring in telehealth was perceived by APNs. The findings of the study can make important contributions in improving our profession's preparation of future telehealth APNs. The study findings also can lend themselves to developing an instrument to measure caring in telehealth. The study findings also contribute to the nursing literature in a number of ways.

Sequential injection chemiluminescence immunoassay for nonionic surfactants by using magnetic microbeads

International Nuclear Information System (INIS)

Zhang Ruiq; Nakajima, Hizuru; Soh, Nobuaki; Nakano, Koji; Masadome, Takashi; Nagata, Kazumi; Sakamoto, Kazuhira; Imato, Toshihiko

2007-01-01

A rapid and sensitive immunoassay based on a sequential injection analysis (SIA) using magnetic microbeads for the determination of alkylphenol polyethoxylates (APnEOs) is described. An SIA system was constructed from a syringe pump, a switching valve, a flow-through type immunoreaction cell equipped with a photon counting unit and a neodymium magnet. Magnetic beads, to which an anti-APnEOs monoclonal antibody was immobilized, were used as a solid support in an immunoassay. The introduction, trapping and release of the magnetic beads in and from the immunoreaction cell were controlled by means of a neodymium magnet and adjusting the flow of a carrier solution. The immunoassay was based on an indirect competitive immunoreaction of an anti-APnEOs monoclonal antibody immobilized on the magnetic beads with a sample APnEOs and a horseradish peroxidase (HRP)-labeled APnEOs in the same sample solution, and was based on the subsequent chemiluminscence reaction of HRP on the magnetic microbeads with a luminol solution containing hydrogen peroxide and p-iodophenol. The anti-APnEOs antibody was immobilized on the magnetic microbeads by coupling the antibody with the magnetic beads after activation of a carboxylate moiety on the surface of the magnetic beads that had been coated with a polylactic acid film. The antibody immobilized magnetic beads were introduced in the immunoreaction cell and trapped in it by the neodymium magnet, which was equipped beneath the immunoreaction cell. An APnEOs sample solution containing the HRP-labeled APnEOs at a constant concentration, and a luminol solution containing hydrogen peroxide and p-iodophenol were sequentially introduced into the immunoreaction cell, according to an SIA programmed sequence. Chemiluminescence emission was monitored by means of a photon counting unit located at the upper side of the immunoreaction cell by collecting the emitted light with a lens. A typical sigmoidal calibration curve was obtained, when the logarithm

Critical care nurse practitioners and clinical nurse specialists interface patterns with computer-based decision support systems.

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Weber, Scott

2007-11-01

The purposes of this review are to examine the types of clinical decision support systems in use and to identify patterns of how critical care advanced practice nurses (APNs) have integrated these systems into their nursing care patient management practices. The decision-making process itself is analyzed with a focus on how automated systems attempt to capture and reflect human decisional processes in critical care nursing, including how systems actually organize and process information to create outcome estimations based on patient clinical indicators and prognosis logarithms. Characteristics of APN clinicians and implications of these characteristics on decision system use, based on the body of decision system user research, are introduced. A review of the Medline, Ovid, CINAHL, and PubMed literature databases was conducted using "clinical decision support systems,"computerized clinical decision making," and "APNs"; an examination of components of several major clinical decision systems was also undertaken. Use patterns among APNs and other clinicians appear to vary; there is a need for original research to examine how APNs actually use these systems in their practices in critical care settings. Because APNs are increasingly responsible for admission to, and transfer from, critical care settings, more understanding is needed on how they interact with this technology and how they see automated decision systems impacting their practices. APNs who practice in critical care settings vary significantly in how they use the clinical decision systems that are in operation in their practice settings. These APNs must have an understanding of their use patterns with these systems and should critically assess whether their patient care decision making is affected by the technology.

Association of Adiponectin With Cancer and All-Cause Mortality in a Japanese Community-Dwelling Elderly Cohort: A Case-Cohort Study.

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Kojima, Reiji; Ukawa, Shigekazu; Zhao, Wenjing; Suzuki, Koji; Yamada, Hiroya; Tsushita, Kazuyo; Kawamura, Takashi; Okabayashi, Satoe; Wakai, Kenji; Noma, Hisashi; Ando, Masahiko; Tamakoshi, Akiko

2018-03-24

Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on cardiovascular disease, but data on the relationship between plasma APN and cancer mortality is exiguous. We investigated whether APN is associated with cancer mortality in community-dwelling elderly people. We conducted a case-cohort study within the New Integrated Suburban Seniority Investigation (NISSIN) Project using a randomly drawn sub-cohort of 697 subjects (351 men and 346 women; mean age 64.5 [standard deviation, 0.5] years) among whom we compared cases of all-cause death (n = 269) and cancer death (n = 149) during a mean follow-up duration of 10.8 (standard deviation, 3.7) years. Associations between APN and mortality were assessed using weighted Cox regression analyses. We observed significant positive associations between the APN concentration and cancer death in the first and third APN tertiles compared with the second APN tertile (hazard ratio [HR] T1 vs T2 , 1.67; 95% confidence interval [CI], 1.00-2.79 and HR T3 vs T2 , 2.10; 95% CI, 1.30-3.40). Further adjustment for possible confounders attenuated the association (HR T1 vs T2 , 1.63; 95% CI, 0.93-2.84 and HR T3 vs T2 , 2.10; 95% CI, 1.26-3.50). A similar but weaker association was seen for all-cause mortality (multivariate HR T1 vs T2 , 1.45; 95% CI, 0.95-2.21 and HR T3 vs T2 , 1.51; 95% CI, 1.01-2.25). Plasma APN and cancer mortality have a significant relationship among community-dwelling elderly people, which warrants further study.

Adiponectin enhances osteogenic differentiation in human adipose-derived stem cells by activating the APPL1-AMPK signaling pathway

Energy Technology Data Exchange (ETDEWEB)

Chen, Tong; Wu, Yu-wei; Lu, Hui; Guo, Yuan [Second Dental Center, Peking University School and Hospital of Stomatology, Beijing (China); National Engineering Laboratory for Digital and Material Technology of Stomatology, Peking University School and Hospital of Stomatology, Beijing (China); Tang, Zhi-hui, E-mail: tang_zhihui@live.cn [Second Dental Center, Peking University School and Hospital of Stomatology, Beijing (China); National Engineering Laboratory for Digital and Material Technology of Stomatology, Peking University School and Hospital of Stomatology, Beijing (China)

2015-05-29

Human adipose-derived stem cells (hASCs) are multipotent progenitor cells with multi-lineage differentiation potential including osteogenesis and adipogenesis. While significant progress has been made in understanding the transcriptional control of hASC fate, little is known about how hASC differentiation is regulated by the autocrine loop. The most abundant adipocytokine secreted by adipocytes, adiponectin (APN) plays a pivotal role in glucose metabolism and energy homeostasis. Growing evidence suggests a positive association between APN and bone formation yet little is known regarding the direct effects of APN on hASC osteogenesis. Therefore, this study was designed to investigate the varied osteogenic effects and regulatory mechanisms of APN in the osteogenic commitment of hASCs. We found that APN enhanced the expression of osteoblast-related genes in hASCs, such as osteocalcin, alkaline phosphatase, and runt-related transcription factor-2 (Runx2, also known as CBFa1), in a dose- and time-dependent manner. This was further confirmed by the higher expression levels of alkaline phosphatase and increased formation of mineralization nodules, along with the absence of inhibition of cell proliferation. Importantly, APN at 1 μg/ml was the optimal concentration, resulting in maximum deposition of calcium nodules, and was significant superior to bone morphogenetic protein 2. Mechanistically, we found for the first time that APN increased nuclear translocation of the leucine zipper motif (APPL)-1 as well as AMP-activated protein kinase (AMPK) phosphorylation, which were reversed by pretreatment with APPL1 siRNA. Our results indicate that APN promotes the osteogenic differentiation of hASCs by activating APPL1-AMPK signaling, suggesting that manipulation of APN is a novel therapeutic target for controlling hASC fate. - Highlights: • Adiponectin enhances osteogenic differentiation in human adipose-derived stem cells. • The knock-down of APPL1 block the enhancement of

Implementation strategy for advanced practice nursing in primary health care in Latin America and the Caribbean.

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Oldenburger, David; De Bortoli Cassiani, Silvia Helena; Bryant-Lukosius, Denise; Valaitis, Ruta Kristina; Baumann, Andrea; Pulcini, Joyce; Martin-Misener, Ruth

2017-06-08

SYNOPSIS Advanced practice nursing (APN) is a term used to describe a variety of possible nursing roles operating at an advanced level of practice. Historically, APN roles haves evolved informally, out of the need to improve access to health care services for at-risk and disadvantaged populations and for those living in underserved rural and remote communities. To address health needs, especially ones related to primary health care, nurses acquired additional skills through practice experience, and over time they developed an expanded scope of practice. More recently, APN roles have been developed more formally through the establishment of graduate education programs to meet agreed-upon competencies and standards for practice. The introduction of APN roles is expected to advance primary health care throughout Latin America and the Caribbean, where few such roles exist. The purpose of the paper is to outline an implementation strategy to guide and support the introduction of primary health care APN roles in Latin America and the Caribbean. The strategy includes the adaptation of an existing framework, utilization of recent research evidence, and application of knowledge from experts on APN and primary health care. The strategy consists of nine steps. Each step includes a national perspective that focuses on direct country involvement in health workforce planning and development and on implementation. In addition, each step incorporates an international perspective on encouraging countries that have established APN programs and positions to collaborate in health workforce development with nations without advanced practice nursing.

Knowledge Transfer and Dissemination of Advanced Practice Nursing Information and Research to Acute-Care Administrators.

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Carter, Nancy; Dobbins, Maureen; Peachey, Gladys; Hoxby, Heather; Ireland, Sandra; Akhtar-Danesh, Noori; DiCenso, Alba

2014-03-01

The objective of this study was to ascertain the information needs and knowledge-dissemination preferences of acute-care administrators with respect to advanced practice nursing (APN). Supportive leadership is imperative for the success of APN roles and administrators need up-to-date research evidence and information, but it is unclear what the information needs of administrators are and how they prefer to receive the information. A survey tool was developed from the literature and from the findings of a qualitative study with acute-care leaders. Of 107 surveys distributed to nursing administrators in 2 teaching hospitals, 79 (73.8%) were returned. Just over half of respondents reported wanting APN information related to model of care and patient and systems outcomes of APN care; the majority expressed a preference for electronic transmission of the information. Researchers need multiple strategies for distributing context-specific APN evidence and information to nursing administrators. Copyright© by Ingram School of Nursing, McGill University.

Adiponectin attenuates lung fibroblasts activation and pulmonary fibrosis induced by paraquat.

Science.gov (United States)

Yao, Rong; Cao, Yu; He, Ya-rong; Lau, Wayne Bond; Zeng, Zhi; Liang, Zong-an

2015-01-01

Pulmonary fibrosis is one of the most common complications of paraquat (PQ) poisoning, which demands for more effective therapies. Accumulating evidence suggests adiponectin (APN) may be a promising therapy against fibrotic diseases. In the current study, we determine whether the exogenous globular APN isoform protects against pulmonary fibrosis in PQ-treated mice and human lung fibroblasts, and dissect the responsible underlying mechanisms. BALB/C mice were divided into control group, PQ group, PQ + low-dose APN group, and PQ + high-dose APN group. Mice were sacrificed 3, 7, 14, and 21 days after PQ treatment. We compared pulmonary histopathological changes among different groups on the basis of fibrosis scores, TGF-β1, CTGF and α-SMA pulmonary content via Western blot and real-time quantitative fluorescence-PCR (RT-PCR). Blood levels of MMP-9 and TIMP-1 were determined by ELISA. Human lung fibroblasts WI-38 were divided into control group, PQ group, APN group, and APN receptor (AdipoR) 1 small-interfering RNA (siRNA) group. Fibroblasts were collected 24, 48, and 72 hours after PQ exposure for assay. Cell viability and apoptosis were determined via Kit-8 (CCK-8) and fluorescein Annexin V-FITC/PI double labeling. The protein and mRNA expression level of collagen type III, AdipoR1, and AdipoR2 were measured by Western blot and RT-PCR. APN treatment significantly decreased the lung fibrosis scores, protein and mRNA expression of pulmonary TGF-β1, CTGF and α-SMA content, and blood MMP-9 and TIMP-1 in a dose-dependent manner (ppulmonary fibrosis in a dose-dependent manner, via suppression of lung fibroblast activation. Functional AdipoR1 are expressed by human WI-38 lung fibroblasts, suggesting potential future clinical applicability of APN against pulmonary fibrosis.

The combination of urinary IL - 6 and renal biometry as useful diagnostic tools to differentiate acute pyelonephritis from lower urinary tract infection

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Sherif Azab

Full Text Available ABSTRACT Objective: To evaluate the role of renal ultrasound (RUS and urinary IL-6 in the differentiation between acute pyelonephritis (APN and lower urinary tract infection (LUTI. Patients and methods: This prospective study was carried out at the Pediatric and urology outpatient and inpatient departments of Cairo University Children's Hospital as well as October 6 University Hospital and it included 155 children between one month and fourteen years old with positive culture UTI. Patients were categorized into APN and LUTI based on their clinical features and laboratory parameters. Thirty healthy children, age and sex matched constituted the control group. Children with positive urine cultures were treated with appropriate antibiotics. Before treatment, urinary IL-6 was measured by enzyme immunoassay technique (ELISA, and renal ultrasound (RUS was done. CRP (C-reactive protein, IL-6 and RUS were repeated on the 14th day of antibiotic treatment to evaluate the changes in their levels in response to treatment. Results: UIL-6 levels were more significantly higher in patients with APN than in patients with LUTI (24.3±19.3pg/mL for APN vs. 7.3±2.7pg/mL in LUTI (95% CI: 2.6-27.4; p20pg/mL and serum CRP >20μg/mL were highly reliable markers of APN. Mean renal volume and mean volume difference between the two kidneys in the APN group were more than that of the LUTI and control groups (P<0.001. Renal volume between 120-130% of normal was the best for differentiating APN from LUTI. Conclusions: RUS and urinary IL-6 levels have a highly dependable role in the differentiation between APN and LUTI especially in places where other investigations are not available and/ or affordable.

Studi Eksperimental dan Pemodelan Matematika Proses Pengeringan Kakao Dengan Energi Surya Secara Intermitten

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Haznam Putra

2014-06-01

dimulai dari proses fermentasi kakao. Dengan beberapa kali pengujian kakao, diambil hasil salah satu pengujian dimana hasil fermentasi kakao yang telah dicuci kemudian dikeringkan dari kadar air 55,83% menjadi 7,01% yang berlangsung selama tiga hari yakni 22–24 April 2013 dari pukul 07.00 – 17.00 WIB (Intermitten.  Penelitian dilakukan di Laboratorium Solar Energi Jurusan Teknik Mesin Fakultas Teknik Universitas Sumatera Utara Medan yang berada di kota Medan dengan posisi 3.36 °LU – 98.4 °BT, ketinggian di atas permukaan laut 200 meter dan waktu meridian (7 + GMT. Dari hasil percobaan percobaan didapat persamaan model matematika untuk pengeringan kakao secara intermitten, dengan nilai koefisien difusifitas berada pada nilai 1,39 x10-10 – 1,85 x10-10 m2/detik, selain itu kualitas kakao yang dikeringkan lebih baik dari segi warna dan tidak berjamur dibandingkan dengan kakao yang dikeringkan secara langsung dibawah sinar matahari. st1\\:*{behavior:url(#ieooui } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

Advanced practice nurses core competencies: a framework for developing and testing an advanced practice nurse discharge intervention.

Science.gov (United States)

Cooke, Liz; Gemmill, Robin; Grant, Marcia

2008-01-01

The purpose of this paper was to describe evidenced-based interventions as implemented by advanced practice nurses (APNs) conducting intervention research with a vulnerable population of blood and marrow transplant patients. In addition, each of the 6 core competencies of the APN role identified by Hamric are outlined and applied using a patient case study. These competencies are the following: direct clinical practice, expert coaching and advice, consultation, research skills, clinical and professional leadership, collaboration, and ethical decision making. This article chronicles a typical patient's journey through a post-hospital discharge nursing research study involving APNs as "intervention nurses" and discusses the various aspects of the APN core competencies throughout the process.

Perbandingan Daya Hambat Larutan Antiseptik Povidone iodine dengan Ekstrak Daun Sirih terhadap Candida albicans secara In Vitro

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Septriana Putri

2015-09-01

Full Text Available Abstrak Candida albicansb (C. albicans adalah salah satu mikroorganisme penyebab masalah kesehatan reproduksi wanita, yaitu keputihan (fluor albus. Penggunaan larutan povidone iodine dan bahan alam seperti ekstrak daun sirih menjadi pilihan masyarakat sebagai pembersih alat kewanitaan. Tujuan penelitian ini adalah untuk membandingkandaya hambat larutan antiseptik povidone iodine dan ekstrak daun sirih terhadap jamur C. albicans secara in vitro. Penelitian dilakukan terhadap lima isolat jamur C. albicans dengan larutan kontrol akuades.Perlakuan terdiri dari povidone iodine, ekstrak daun sirih dengan konsentrasi 5%, 10%, dan 20%.Hasil penelitian menunjukkan bahwa povidone iodine memiliki daya hambat terhadap C. albicans. Ekstrak daun sirih dengan konsentrasi 5% dan 10% tidak memiliki daya hambat terhadap C. albicans, namun ekstrak daun sirih konsentrasi 20% memiliki daya hambat terhadap C. albicans. Analisis statistik dengan uji ANOVA yang dilanjutkan dengan uji Post-hoc menunjukkan perbedaan bermakna antara daya hambat larutan povidone iodine dan ekstrak daun sirih 20% terhadap kontrol(p < 0.05.Larutan povidone iodine memiliki daya hambat dua kali lebih besar terhadap pertumbuhan C. albicans dibandingkan ekstrak daun sirih 20%. Dari penelitian ini dapat disimpulkan bahwa larutan povidone iodine dan ekstrak daun sirih 20% dapat menghambat pertumbuhan jamur C. albicans secara in vitro. Kata kunci: povidone iodine, ekstrak daun sirih, Candida albicansAbstract Candida albicans (C. albicans is one of the frequent causes of  reproductive health problems in women, namely vaginal discharge (fluor albus. The antiseptic solution, povidone iodine, is still an option to overcome vaginal discharge. The use of natural materials such as betel (Piper betle L. leaves extract also become a popular choice as adouche for women. The objective of this study was to compare the inhibitory activity of povidone iodine solution and betel leaf extract against the growth of

Porcine aminopeptidase N mediated polarized infection by porcine epidemic diarrhea virus in target cells

Energy Technology Data Exchange (ETDEWEB)

Cong, Yingying; Li, Xiaoxue; Bai, Yunyun [College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030 (China); Lv, Xiaonan [College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030 (China); CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience & Technology of China, Beijing 100090 (China); Herrler, Georg [Institute for Virology, University of Veterinary Medicine, Hannover D-30559 (Germany); Enjuanes, Luis [Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Cantoblanco, Madrid (Spain); Zhou, Xingdong [College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030 (China); Qu, Bo [Faculty of Life Sciences, Northeast Agricultural University, Harbin 150030 (China); Meng, Fandan [Institute for Virology, University of Veterinary Medicine, Hannover D-30559 (Germany); Cong, Chengcheng [College Animal Husbandry and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110161 (China); Ren, Xiaofeng; Li, Guangxing [College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030 (China)

2015-04-15

Infection of polarized intestinal epithelial cells by porcine epidemic diarrhea virus (PEDV) was characterized. Indirect immunofluorescence assay, real-time PCR, and transmission electron microscopy confirmed PEDV can be successfully propagated in immortalized swine small intestine epithelial cells (IECs). Infection involved porcine aminpeptidase N (pAPN), a reported cellular receptor for PEDV, transient expression of pAPN and siRNA targeted pAPN increased and decreased the infectivity of PEDV in IECs, respectively. Subsequently, polarized entry into and release from both Vero E6 and IECs was analyzed. PEDV entry into polarized cells and pAPN grown on membrane inserts occurs via apical membrane. The progeny virus released into the medium was also quantified which demonstrated that PEDV is preferentially released from the apical membrane. Collectively, our data demonstrate that pAPN, the cellular receptor for PEDV, mediates polarized PEDV infection. These results imply the possibility that PEDV infection may proceed by lateral spread of virus in intestinal epithelial cells. - Highlights: • PEDV infection of polarized intestinal epithelial cells (IECs) was characterized. • Porcine aminpeptidase N (pAPN) facilitated PEDV infection in IECs. • PEDV entry into and release from polarized cell via its apical membrane. • PEDV infection may proceed by lateral spread of virus in IECs.

Childhood acute pyelonephritis: comparison of power Doppler sonography and Tc-DMSA scintigraphy

Energy Technology Data Exchange (ETDEWEB)

Stogianni, Aggeliki; Oikonomou, Ippoliti; Dimitriadis, Athanasios [Aristotle University of Thessaloniki, Department of Radiology, AHEPA Hospital, Thessaloniki (Greece); Nikolopoulos, Panagiotis [424 Army Hospital, Department of Radiology, Thessaloniki (Greece); Gatzola, Magdalini [Aristotle University of Thessaloniki, 2nd Paediatric Clinic, AHEPA Hospital, Thessaloniki (Greece); Balaris, Vassilios [Aristotle University of Thessaloniki, Department of Nuclear Medicine, AHEPA Hospital, Thessaloniki (Greece); Farmakiotis, Dimitrios [Infectious Diseases Hospital of Thessaloniki, Department of Medicine, Thessaloniki (Greece)

2007-07-15

Tc 99m DMSA scintigraphy is regarded as the gold standard for the detection and localization of acute pyelonephritis (APN) in children. Power Doppler sonography (PD US) is a radiation-free and cost-effective technique that could be useful in the diagnosis of APN in children. To compare the predictive value of PD US with DMSA scintigraphy in the diagnosis of APN in children. A total of 74 neonates and children with clinical findings consistent with possible upper urinary tract infection were evaluated with PD US and DMSA scintigraphy. Children with anatomic (grey-scale) abnormalities were excluded. A total of 147 kidneys were examined within the first 48 h after the onset of symptoms. Each kidney was divided into three zones (upper, middle, and lower third). APN was diagnosed by PD US in 46 kidneys. Sensitivity and specificity for detecting APN using DMSA scintigraphy as the reference standard were 73.8% and 85.7%, respectively. There was good agreement between PD US and DMSA scintigraphy in the localization of lesions. In clinically suspected APN, PD US has acceptable specificity and sensitivity, if performed within the first 48 h and could be helpful in neonates and children under 3 months of age in whom the use of scintigraphy is generally discouraged. (orig.)

Porcine aminopeptidase N mediated polarized infection by porcine epidemic diarrhea virus in target cells

International Nuclear Information System (INIS)

Cong, Yingying; Li, Xiaoxue; Bai, Yunyun; Lv, Xiaonan; Herrler, Georg; Enjuanes, Luis; Zhou, Xingdong; Qu, Bo; Meng, Fandan; Cong, Chengcheng; Ren, Xiaofeng; Li, Guangxing

2015-01-01

Infection of polarized intestinal epithelial cells by porcine epidemic diarrhea virus (PEDV) was characterized. Indirect immunofluorescence assay, real-time PCR, and transmission electron microscopy confirmed PEDV can be successfully propagated in immortalized swine small intestine epithelial cells (IECs). Infection involved porcine aminpeptidase N (pAPN), a reported cellular receptor for PEDV, transient expression of pAPN and siRNA targeted pAPN increased and decreased the infectivity of PEDV in IECs, respectively. Subsequently, polarized entry into and release from both Vero E6 and IECs was analyzed. PEDV entry into polarized cells and pAPN grown on membrane inserts occurs via apical membrane. The progeny virus released into the medium was also quantified which demonstrated that PEDV is preferentially released from the apical membrane. Collectively, our data demonstrate that pAPN, the cellular receptor for PEDV, mediates polarized PEDV infection. These results imply the possibility that PEDV infection may proceed by lateral spread of virus in intestinal epithelial cells. - Highlights: • PEDV infection of polarized intestinal epithelial cells (IECs) was characterized. • Porcine aminpeptidase N (pAPN) facilitated PEDV infection in IECs. • PEDV entry into and release from polarized cell via its apical membrane. • PEDV infection may proceed by lateral spread of virus in IECs

Diagnostic performance of procalcitonin for hospitalised children with acute pyelonephritis presenting to the paediatric emergency department.

Science.gov (United States)

Chen, Shan-Ming; Chang, Hung-Ming; Hung, Tung-Wei; Chao, Yu-Hua; Tsai, Jeng-Dau; Lue, Ko-Huang; Sheu, Ji-Nan

2013-05-01

Urinary tract infection (UTI) is a common bacterial infection in children that can result in permanent renal damage. This study prospectively assessed the diagnostic performance of procalcitonin (PCT) for predicting acute pyelonephritis (APN) among children with febrile UTI presenting to the paediatric emergency department (ED). Children aged ≤10 years with febrile UTI admitted to hospital from the paediatric ED were prospectively studied. Blood PCT, C reactive protein (CRP) and white blood cell (WBC) count were measured in the ED. Sensitivity, specificity, predictive values, multilevel likelihood ratios, receiver operating characteristic (ROC) curve analysis and multivariate logistic regression were used to assess quantitative variables for diagnosing APN. The 136 enrolled patients (56 boys and 80 girls; age range 1 month to 10 years) were divided into APN (n=87) and lower UTI (n=49) groups according to (99m)Tc-dimercaptosuccinic acid scan results. The cut-off value for maximum diagnostic performance of PCT was 1.3 ng/ml (sensitivity 86.2%, specificity 89.8%). By multivariate regression analysis, only PCT and CRP were retained as significant predictors of APN. Comparing ROC curves, PCT had a significantly greater area under the curve than CRP, WBC count and fever for differentiating between APN and lower UTI. PCT has better sensitivity and specificity than CRP and WBC count for distinguishing between APN and lower UTI. PCT is a valuable marker for predicting APN in children with febrile UTI. It may be considered in the initial investigation and therapeutic strategies for children presenting to the ED.

Clinical significance of the changes of serum IL-8 and IL-12 levels in pediatric patients with anaphylactoid purpura (AP)

International Nuclear Information System (INIS)

Liang Zhenming; Liu Xia

2005-01-01

Objective: To explore the role of IL-8 and IL-12 in the pathogenesis of anaphylactoid purpura (AP) and anaphylactoid purpura nephritis (APN). Methods: Serum IL-8 (with RIA) and IL-12 (with ELISA) levels were measured in 32 pediatric patients with anaphylactoid purpura (AP), 11 pediatric patients with anaphylactoid purpura nephritis (APN) and 15 controls. Results: During acute stage, serum IL-8 and IL-12 levels in both the AP and APN patients were significantly higher than those in controls and remained higher during convalescence. IL-8 and IL-12 levels were mutually positively correlated in acute stage. Conclusion: IL-8 and IL-12 participated in the pathogenesis of AP and APN. Theoretically, antagonist to those cytokines might be of clinical benefits. (authors)

Globular Adiponectin Inhibits the Apoptosis of Mesenchymal Stem Cells Induced by Hypoxia and Serum Deprivation via the AdipoR1-Mediated Pathway

OpenAIRE

Xia-Qiu Tian; Yue-Jin Yang; Qing Li; Pei-Sen Huang; Xiang-Dong Li; Chen Jin; Kang Qi; Lei-Pei Jiang; Gui-Hao Chen

2016-01-01

Background/Aims: Poor viability of transplanted mesenchymal stem cells (MSCs) within the ischemic heart limits their therapeutic potential for cardiac repair. Globular adiponectin (gAPN) exerts anti-apoptotic effects on several types of stem cells. Herein, we investigated the effect of gAPN on the MSCs against apoptosis induced by hypoxia and serum deprivation (H/SD). Methods: MSCs exposed to H/SD conditions were treated with different concentrations of gAPN. To identify the main type of rece...

Removal of Malachite Green from water using hydrothermally carbonized pine needles

KAUST Repository

Hammud, Hassan Hasan

2015-01-01

Hydrothermal carbonization of pine needles (HTC-PN) and their oxidized-activated form HTC-APN are prepared and applied for the adsorption of Malachite Green (MG) in aqueous solution. The HTC materials were characterized by thermal and TEM analysis. Adsorbent dose, initial concentration of MG, contact time, temperature and pH effect on MG adsorption onto the HTC materials were studied. The adsorption equilibrium data was best fitted by the Langmuir isotherm model and the adsorption kinetics followed pseudo-second-order models for both HTC-PN and HTC-APN. The maximum capacity predicted by the Langmuir nonlinear model is 52.91 and 97.08 mg g-1 for uptake of MG by HTC-PN and HTC-APN, respectively, at 30 °C. Thermodynamic investigations showed that the adsorption is spontaneous and endothermic in nature. Results suggest HTC-APN can be used as a low-cost adsorbent for MG removal from industrial wastewater. Yoon-Nelson is the best model with a column capacity of 38.3 mg g-1 for the adsorption of MG onto HTC-APN. This journal is

Description and evaluation of an initiative to develop advanced practice nurses in mainland China.

Science.gov (United States)

Wong, Frances Kam Yuet; Peng, Gangyi; Kan, Eva C; Li, Yajie; Lau, Ada T; Zhang, Liying; Leung, Annie F; Liu, Xueqin; Leung, Vilna O; Chen, Weiju; Li, Ming

2010-05-01

This paper describes an initiative to develop Advanced Practice Nurses (APNs) in mainland China and evaluation of the outcomes of the described programme. The pioneer project was an APN postgraduate programme involving 38 students conducted in Guangzhou, China during 2004-2005. Data related to curriculum content and process, student performance, self-reported competence and programme effects were collected. Quantitative data such as demographic data, student performance were analysed using descriptive statistics and the pre and post self-reported practice of competence was compared using chi-square test. Qualitative data such as case reports and interviews were examined using thematic analyses. Reflective journals and case studies revealed the attributes of APNs in managing clinical cases at advanced level, applying theory into practice and exercising evidence-based practice. The relatively modest self-reported practice of competence suggested that the graduates were novice APNs and needed continued development after the completion of the programme. This study reports the experience of an initiative in China and suggests a useful curriculum framework for educating APNs. Copyright 2009 Elsevier Ltd. All rights reserved.

MODEL PERPINDAHAN MASSA PADA EKSTRAKSI SAPONIN BIJI TEH DENGAN PELARUT ISOPROPIL ALKHOHOL 50% DENGAN PENGONTAKAN SECARA DISPERSI MENGGUNAKAN ANALISIS DIMENSI

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Susiana Prasetyo

2012-11-01

Full Text Available Indonesia merupakan salah satu penghasil teh terbesar di dunia. Menurut data dari Deptan 2010, dengan luas lahan sebesar 127712 ha, Indonesia dapat menghasilkan produktivitas teh sebesar 153971 ton/tahun. Namun sayangnya, selama ini pemanfaatan tanaman teh di Indonesia masih terbatas pada pucuk daunnya saja. Bagian tanaman teh yang memiliki kandungan potensial namun belum dimanfaatkan adalah  biji teh, mengandung 26% saponin, 20-60% minyak dan 11% protein. Saponin merupakan salah satu komponen bioaktif yang telah dimanfaatkan sebagai insektisida pembasmi hama pada tambak udang, bahan baku industri deterjen, shampoo, minuman bir, pembentuk busa pada pemadam kebakaran, dan dapat dimanfaatkan pula sebagai pupuk organik. Pada penelitian ini, saponin biji teh diperoleh melalui ekstraksi biji teh pasca pengepresan menggunakan pelarut IPA 50% secara batch di dalam sebuah ekstraktor berkapasitas 2 L. Pengontakan solvent dengan biji teh dilakukan secara dispersi. Pada penelitian ini, rasio massa pelarut terhadap massa umpan diset 20:1; temperatur divariasikan 25-60 oC, kecepatan pengadukan 100-400 rpm, serta ukuran biji teh divariasikan -40+50 mesh s.d -100+200 mesh. Ekstraksi dilakukan hingga tercapai kesetimbangan. Ekstrak yang diperoleh dipekatkan menggunakan rotavapor vakum pada temperatur di bawah 40oC. Ekstrak pekat saponin kasar yang didapat dimurnikan dengan penambahan eter, etanol dan petroleum eter secara bertahap sehingga diperoleh endapan saponin murni yang kemudian dikeringkan menggunakan tray drier pada temperatur 40oC. Pada penelitian ini, model perpindahan massa sederhana dikembangkan untuk menggambarkan proses ekstraksi padat-cair saponin biji teh. Berdasarkan hasil analisis dimensi diperoleh hubungan antara koefisien perpindahan massa volumetrik (kLa pada lapisan antar fasa padat-cair dengan variabel-variabel ekstraksi yang dinyatakan dalam persamaan bilangan tak berdimensi dengan ralat rata-rata 3,7904 %.DIMENSIONAL ANALYSIS FOR MASS

Binding determinants in the interplay between porcine aminopeptidase N and enterotoxigenic Escherichia coli F4 fimbriae.

Science.gov (United States)

Xia, Pengpeng; Quan, Guomei; Yang, Yi; Zhao, Jing; Wang, Yiting; Zhou, Mingxu; Hardwidge, Philip R; Zhu, Jianzhong; Liu, Siguo; Zhu, Guoqiang

2018-02-26

The binding of F4 + enterotoxigenic Escherichia coli (ETEC) and the specific receptor on porcine intestinal epithelial cells is the initial step in F4 + ETEC infection. Porcine aminopeptidase N (APN) is a newly discovered receptor for F4 fimbriae that binds directly to FaeG adhesin, which is the major subunit of the F4 fimbriae variants F4ab, F4ac, and F4ad. We used overlapping peptide assays to map the APN-FaeG binding sites, which has facilitated in the identifying the APN-binding amino acids that are located in the same region of FaeG variants, thereby limiting the major binding regions of APN to 13 peptides. To determine the core sequence motif, a panel of FaeG peptides with point mutations and FaeG mutants were constructed. Pull-down and binding reactivity assays using piglet intestines determined that the amino acids G159 of F4ab, N209 and L212 of F4ac, and A200 of F4ad were the critical residues for APN binding of FaeG. We further show using ELISA and confocal microscopy assay that amino acids 553-568, and 652-670 of the APN comprise the linear epitope for FaeG binding in all three F4 fimbriae variants.

Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies.

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Juan Reguera

Full Text Available The coronaviruses (CoVs are enveloped viruses of animals and humans associated mostly with enteric and respiratory diseases, such as the severe acute respiratory syndrome and 10-20% of all common colds. A subset of CoVs uses the cell surface aminopeptidase N (APN, a membrane-bound metalloprotease, as a cell entry receptor. In these viruses, the envelope spike glycoprotein (S mediates the attachment of the virus particles to APN and subsequent cell entry, which can be blocked by neutralizing antibodies. Here we describe the crystal structures of the receptor-binding domains (RBDs of two closely related CoV strains, transmissible gastroenteritis virus (TGEV and porcine respiratory CoV (PRCV, in complex with their receptor, porcine APN (pAPN, or with a neutralizing antibody. The data provide detailed information on the architecture of the dimeric pAPN ectodomain and its interaction with the CoV S. We show that a protruding receptor-binding edge in the S determines virus-binding specificity for recessed glycan-containing surfaces in the membrane-distal region of the pAPN ectodomain. Comparison of the RBDs of TGEV and PRCV to those of other related CoVs, suggests that the conformation of the S receptor-binding region determines cell entry receptor specificity. Moreover, the receptor-binding edge is a major antigenic determinant in the TGEV envelope S that is targeted by neutralizing antibodies. Our results provide a compelling view on CoV cell entry and immune neutralization, and may aid the design of antivirals or CoV vaccines. APN is also considered a target for cancer therapy and its structure, reported here, could facilitate the development of anti-cancer drugs.

The combination of urinary IL - 6 and renal biometry as useful diagnostic tools to differentiate acute pyelonephritis from lower urinary tract infection.

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Azab, Sherif; Zakaria, Mostafa; Raafat, Mona; Seief, Hadeel

2016-01-01

To evaluate the role of renal ultrasound (RUS) and urinary IL-6 in the differentiation between acute pyelonephritis (APN) and lower urinary tract infection (LUTI). This prospective study was carried out at the Pediatric and urology outpatient and inpatient departments of Cairo University Children's Hospital as well as October 6 University Hospital and it included 155 children between one month and fourteen years old with positive culture UTI. Patients were categorized into APN and LUTI based on their clinical features and laboratory parameters. Thirty healthy children, age and sex matched constituted the control group. Children with positive urine cultures were treated with appropriate antibiotics. Before treatment, urinary IL-6 was measured by enzyme immunoassay technique (ELISA), and renal ultrasound (RUS) was done. CRP (C-reactive protein), IL-6 and RUS were repeated on the 14th day of antibiotic treatment to evaluate the changes in their levels in response to treatment. UIL-6 levels were more significantly higher in patients with APN than in patients with LUTI (24.3±19.3pg/mL for APN vs. 7.3±2.7pg/mL in LUTI (95% CI: 2.6-27.4; p20pg/mL and serum CRP >20μg/mL were highly reliable markers of APN. Mean renal volume and mean volume difference between the two kidneys in the APN group were more than that of the LUTI and control groups (Purinary IL-6 levels have a highly dependable role in the differentiation between APN and LUTI especially in places where other investigations are not available and/ or affordable. Copyright© by the International Brazilian Journal of Urology.

Efektifitas Jahe Merah (Zingiber officinale Var. Rubrum sebagai Additif Pakan dan Antimikrobia terhadap Pertumbuhan Bakteri Anaerob dan Coliform Secara In Vivo pada Ayam Pedaging

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J.R. Manullang

2015-10-01

Full Text Available Jahe merah (Zingiber officinale Var. Rubrum dikenal sebagai bakteriasida. Penelitian ini bertujuan untuk mengetahui aktivitas antibakterial bubuk jahe terhadap pertumbuhan bakteri anaerob dan coliform (Escherichia coli dan Salmonella sp. secara in vivo pada Broiler. Penelitian ini menggunakan dua puluh empat DOC dengan berat badan 40,7 g. Pemberian bubuk jahe diberikan pada Broiler selama 5 hari dengan konsentrasi ekstrak jahe merah yaitu, 0,5, 1, dan 1,5% per kg pakan. Peubah yang diamati adalah berat badan, asupan pakan dan koloni bakteri. Hasil penelitian menunjukkan terdapat pengaruh ekstrak jahe merah pada total koloni bakteri yang cenderung menurun dengan semakin tinggi konsentrasi ekstrak jahe merah, semakin tinggi efek hambatan pertumbuhan bakteri. Dapat disimpulkan bahwa ekstrak jahe merah memiliki sejumlah aktivitas antibakteri untuk pertumbuhan bakteri anaerob dan coliform (E. coli dan Salmonella sp..

The Role of Serum Adiponectin for Outcome Prediction in Patients with Dilated Cardiomyopathy and Advanced Heart Failure

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Vaida Baltrūnienė

2017-01-01

Full Text Available Clinical interpretation of patients’ plasma adiponectin (APN remains challenging; its value as biomarker in dilated cardiomyopathy (DCM is equivocal. We evaluated whether circulating APN level is an independent predictor of composite outcome: death, left ventricle assist device (LVAD implantation, and heart transplantation (HT in patients with nonischemic DCM. 57 patients with nonischemic DCM (average LV diastolic diameter 6.85 cm, LV ejection fraction 26.63%, and pulmonary capillary wedge pressure 22.06  mmHg were enrolled. Patients underwent echocardiography, right heart catheterization, and endomyocardial biopsy. During a mean follow-up of 33.42 months, 15 (26% patients died, 12 (21% patients underwent HT, and 8 (14% patients were implanted with LVAD. APN level was significantly higher in patients who experienced study endpoints (23.4 versus 10.9 ug/ml, p=0.01. APN was associated with worse outcome in univariate Cox proportional hazards model (HR 1.04, CI 1.02–1.07, p=0.001 but lost significance adjusting for other covariates. Average global strain (AGS is an independent outcome predictor (HR 1.42, CI 1.081–1.866, p=0.012. Increased circulating APN level was associated with higher mortality and may be an additive prognostic marker in DCM with advanced HF. Combination of serum (APN, BNP, TNF-α and echocardiographic (AGS markers may increase the HF predicting power for the nonischemic DCM patients.

TNF-alpha, produced by feline infectious peritonitis virus (FIPV)-infected macrophages, upregulates expression of type II FIPV receptor feline aminopeptidase N in feline macrophages.

Science.gov (United States)

Takano, Tomomi; Hohdatsu, Tsutomu; Toda, Ayako; Tanabe, Maki; Koyama, Hiroyuki

2007-07-20

The pathogenicity of feline infectious peritonitis virus (FIPV) is known to depend on macrophage tropism, and this macrophage infection is enhanced by mediation via anti-S antibody (antibody-dependent enhancement, ADE). In this study, we found that TNF-alpha production was increased with viral replication in macrophages inoculated with a mixture of FIPV and anti-S antibody, and demonstrated that this culture supernatant had feline PBMC apoptosis-inducing activity. We also demonstrated that the expression level of the FIPV virus receptor, feline aminopeptidase N (fAPN), was increased in macrophages of FIP cats. For upregulation of TNF-alpha and fAPN in macrophages, viral replication in macrophages is necessary, and their expressions were increased by ADE of FIPV infection. It was demonstrated that a heat-resistant fAPN-inducing factor was present in the culture supernatant of FIPV-infected macrophages, and this factor was TNF-alpha: fAPN expression was upregulated in recombinant feline TNF-alpha-treated macrophages, and FIPV infectivity was increased in these macrophages. These findings suggested that FIPV replication in macrophages increases TNF-alpha production in macrophages, and the produced TNF-alpha acts and upregulates fAPN expression, increasing FIPV sensitivity.

Doctor of Nursing Practice: The Role of the Advanced Practice Nurse.

Science.gov (United States)

Walker, Deborah Kirk; Polancich, Shea

2015-11-01

To explore the evolution and emerging roles of the Doctor of Nursing Practice (DNP) Advanced Practice Nurse (APN). Published peer reviewed literature, cancer-related professional resources, and Web-based resources. The DNP education has prepared the APN for process improvement initiatives, providing quality care, and evidence-based practice translation, which are critical with the emerging trends in this complex health care environment. DNP-prepared APNs have the opportunity to impact oncology care across the cancer trajectory, in various settings, and in various innovative roles as entrepreneurs. Copyright © 2015 Elsevier Inc. All rights reserved.

Abnormal Origin and Course of the Accessory Phrenic Nerve: Case Report.

Science.gov (United States)

Paraskevas, George; Koutsouflianiotis, Konstantinos; Kitsoulis, Panagiotis; Spyridakis, Ioannis

In the current cadaveric study an unusual sizeable accessory phrenic nerve (APN) was encountered emerging from the trunk of the supraclavicular nerves and forming a triangular loop that was anastomosing with the phrenic nerve. That neural loop surrounded the superficial cervical artery which displayed a spiral course. The form of a triangular loop of APN involving the aforementioned artery and originating from the supraclavicular nerve to the best of our knowledge has not been documented previously in the literature. The variable morphological features of the APN along with its clinical applications are briefly discussed.

The Genus Wallemia—From Contamination of Food to Health Threat

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Janja Zajc

2018-05-01

Full Text Available The fungal genus Wallemia of the order Wallemiales (Wallemiomycotina, Basidiomycota comprises the most xerotolerant, xerophilic and also halophilic species worldwide. Wallemia spp. are found in various osmotically challenged environments, such as dry, salted, or highly sugared foods, dry feed, hypersaline waters of solar salterns, salt crystals, indoor and outdoor air, and agriculture aerosols. Recently, eight species were recognized for the genus Wallemia, among which four are commonly associated with foods: W. sebi, W. mellicola, W. muriae and W. ichthyophaga. To date, only strains of W. sebi, W. mellicola and W. muriae have been reported to be related to human health problems, as either allergological conditions (e.g., farmer’s lung disease or rare subcutaneous/cutaneous infections. Therefore, this allergological and infective potential, together with the toxins that the majority of Wallemia spp. produce even under saline conditions, defines these fungi as filamentous food-borne pathogenic fungi.

Effect of Metformin-sustained Release Therapy on Low-density Lipoprotein Size and Adiponectin in the South Indian Women with Polycystic Ovary Syndrome.

Science.gov (United States)

Kumar, D Rama Nagendra; Seshadri, Krishna G; Pandurangi, Monna

2017-01-01

The aim of the study is to compare surrogate markers of cardiovascular disease (CVD) risk, such as adiponectin (APN) levels and low-density lipoprotein (LDL) size, before and after sustained release metformin (Met-SR) therapy in women with polycystic ovarian syndrome (PCOS). Sixty women with PCOS and sixty age-matched controls in the age group 18-45 years were recruited after obtaining informed consent. Women with PCOS were initiated on Met-SR 1 g orally, which was increased to 1.5 g after 2 weeks and continued up to 24 weeks. Demographic data along with family history of type 2 diabetes mellitus, PCOS, and CVD were collected. Lipid profile plasma APN levels and LDL size were measured before and after therapy in the PCOS group. Data analysis was performed using the GraphPad Prism-5 software. Women with PCOS had greater dyslipidemia, lower APN level and LDL size, and increased lipid accumulating product index as compared to controls. After 6 months of Met-SR therapy, women with PCOS demonstrated significant increase in plasma APN levels and LDL size and significant decrease in weight, waist-hip ratio (WHR), waist circumference (WC), and blood pressure (BP). A significant decrease was observed in body mass index (BMI) in the overweight and obese PCOS subgroups. Met-SR increases LDL size, APN concentration and decreases weight, WC, WHR, and BP in patients with PCOS. Met-SR may have salutary effects on LDL particle size through effects on APN levels in women with PCOS.

Evaluation of new American Academy of Pediatrics guideline for febrile urinary tract infection

Science.gov (United States)

Choi, Da Min; Heo, Tae Hoon; Yoo, Kee Hwan

2015-01-01

Purpose To evaluate the practical applications of the diagnosis algorithms recommended by the American Academy of Pediatrics urinary tract infection (UTI) guideline. Methods We retrospectively reviewed the medical records of febrile UTI patients aged between 2 and 24 months. The patients were divided into 3 groups: group I (patients with positive urine culture and urinalysis findings), group II (those with positive urine culture but negative urinalysis findings), and group III (those with negative urine culture but positive urinalysis findings). Clinical, laboratory, and imaging results were analyzed and compared between the groups. Results A total of 300 children were enrolled. The serum C-reactive protein level was lower in children in group II than in those in groups I and III (P<0.05). Children in group I showed a higher frequency of hydronephrosis than those in groups II and III (P<0.05). However, the frequencies of acute pyelonephritis (APN), vesicoureteral reflux (VUR), renal scar, and UTI recurrence were not different between the groups. In group I, recurrence of UTI and presence of APN were associated with the incidence of VUR (recurrence vs. no recurrence: 40% vs.11.4%; APN vs. no APN: 23.3% vs. 9.2%; P<0.05). The incidence of VUR and APN was not related to the presence of hydronephrosis. Conclusion UTI in febrile children cannot be ruled out solely on the basis of positive urinalysis or urine culture findings. Recurrence of UTI and presence of APN may be reasonable indicators of the presence of VUR. PMID:26512260

Mentoring advanced practice nurses in research: recommendations from a pilot program.

Science.gov (United States)

Leung, Doris; Widger, Kimberley; Howell, Doris; Nelson, Sioban; Molassiotis, Alex

2012-01-01

Advanced Practice Nurses (APNs) need research skills to develop and advance their practice and, yet, many have limited access to research training and support following completion of their advanced degree. In this paper we report on the development, delivery, and evaluation of an innovative pilot program that combined research training and one-to-one mentorship for nine APNs in conducting research relevant to their practice. The program was organized within an academic institution and its affiliated hospitals in Toronto, Canada. Our experience with this program may assist those in other organizations to plan and deliver a similar program for APN research mentorship.

Abnormal Origin and Course of the Accessory Phrenic Nerve: Case Report

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George Paraskevas

2016-08-01

Full Text Available In the current cadaveric study an unusual sizeable accessory phrenic nerve (APN was encountered emerging from the trunk of the supraclavicular nerves and forming a triangular loop that was anastomosing with the phrenic nerve. That neural loop surrounded the superficial cervical artery which displayed a spiral course. The form of a triangular loop of APN involving the aforementioned artery and originating from the supraclavicular nerve to the best of our knowledge has not been documented previously in the literature. The variable morphological features of the APN along with its clinical applications are briefly discussed.

99mTc-DMSA scintigraphy in acute urinary tract infection in children

International Nuclear Information System (INIS)

Verboven, M.; Ingels, M.; Delree, M.; Piepsz, A.; Vrije Univ., Brussels

1990-01-01

24 children with symptomatic urinary tract infection (UTI) underwent systematically ultrasound studies (US) and 99m Tc-DMSA renal scans. Among the 15 patients considered as acute pyelonephritis (APN) on clinical grounds, the scan was abnormal in 12 cases, in contrast with only 1 abnormal scan in the clinical subgroup of the lower UTI. Among the 10 abnormal scans that were repeated later on, 6 did completely normalize. US showed only once a parenchymal appearance suggestive for APN. Our findings suggest that the DMSA scan has to be considered at present as the most sensitive imaging technique for the detection of APN. (orig.)

Adiponectin improves coronary no-reflow injury by protecting the endothelium in rats with type 2 diabetes mellitus.

Science.gov (United States)

Han, Xue; Wu, Ye; Liu, Xin; Ma, Lu; Lv, Tingting; Sun, Qi; Xu, Wenli; Zhang, Suli; Wang, Ke; Wang, Wen; Ma, Xinliang; Liu, Huirong

2017-08-31

To determine the effect of adiponectin (APN) on the coronary no-reflow (NR) injury in rats with Type 2 diabetes mellitus (T2DM), 80 male Sprague-Dawley rats were fed with a high-sugar-high-fat diet to build a T2DM model. Rats received vehicle or APN in the last week and then were subjected to myocardial ischemia reperfusion (MI/R) injury. Endothelium-dependent vasorelaxation of the thoracic aorta was significantly decreased and serum levels of endothelin-1 (ET-1), intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were noticably increased in T2DM rats compared with rats without T2DM. Serum APN was positively correlated with the endothelium-dependent vasorelaxation, but negatively correlated with the serum level of ET-1. Treatment with APN improved T2DM-induced endothelium-dependent vasorelaxation, recovered cardiac function, and decreased both NR size and the levels of ET-1, ICAM-1 and VCAM-1. Hypoadiponectinemia was associated with the aggravation of coronary NR in T2DM rats. APN could alleviate coronary NR injury in T2DM rats by protecting the endothelium and improving microcirculation. © 2017 The Author(s).

20 Years of Developing Capacity for Action-Oriented Collaborative Regional Research in the Asia-Pacific Region

Science.gov (United States)

Tupas, L. M.; Stevenson, L. A.

2015-12-01

During its 3rd strategic phase, which ran from 2010 to 2015, the APN provided support for 123 projects through its competitive collaborative regional research and capacity development programmes. With over 250 peer-reviewed papers and the underlying philosophy that the regional research it undertakes engages at least two developing countries, the 3rd strategic phase is not only improving the research capabilities of nations in the region, but is engaging the developing country community in underpinning policy-relevant research. The extent to which science is contributing to policy is further evident in that 69% of the activities conducted had some form of science-policy mechanism built in to the project activities. The period of the 3rd Strategic Phase has been witness to significant changes in the make-up of the "conventional" global change arena, with the transition of some global change programmes into the new "Future Earth" initiative. At the same time, major events such as the Rio+20 Summit, the post-2015 Sustainable Development Goals, the establishment of an IPCC-related platform for biodiversity, i.e. IPBES, and the evolving engagement of science and policy communities has kept the APN busy at what it does best - networking and partnering with the international community. The APN has embraced these changes through its dynamism, allowing the APN to meet not only the needs of the scientists and decision makers its serves in the region but those of the international science communities as well. The challenge for the APN in its next two decades will be to ensure alignment with the transforming global change arena. With key phrases such as "policy-relevant science" and "science-policy interactions" being adopted broadly by the community at large these days, the APN's niche in the global community has received considerable recognition, particularly as other institutions strive to adopt similar practices that the APN has built over the last 20 years.

IDENTIFIKASI SENYAWA EKSTRAK ETANOL DAUN MIMBA (Azadirachta indica A.Juss SEBAGAI ANTIBAKTERI SECARA KLT-BIOAUTOGRAFI TERHADAP BAKTERI Stahpylococcus aureus DAN Escherichia coli

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Nurfijrin Ramadhani

2017-03-01

Full Text Available Rendahnya kesadaran masyarakat dan kurangnya sarana kesehatan membuat penyakit infeksi semakin meningkat. Pengobatan secara alami sekarang menjadi pilihan baru sebagai antibakteri, salah satunya adalah mimba. Penelitian sebelumnya menunjukkan bahwa daun mimba dapat menghambat pertumbuhan bakteri, akan tetapi belum diketahui senyawa apa yang berperan sebagai antibakteri tersebut. Penelitian ini bertujuan untuk mengetahui di dalam daun mimba senyawa yang berperan sebagai antibakteri. Penelitian dilakukan dengan metode KLT Bioautografi langsung, dimana hasil maserasi esktrak etanol daun mimba yang telah dielusi ditempelkan ke media yang telah ditanami bakteri Staphylococcus aureus dan Escherichia coli. Zona hambat yang terbentuk dilakukan identifikasi senyawa dengan menggunakan pereaksi semprot Dragendorf, FeCl3, Sitroborat, Lieberman Bouchardat, dan SbCl3. Hasil uji KLT-Bioautografi menunjukkan bahwa daun mimba dapat menghambat pertumbuhan bakteri yang ditandai dengan terbentuknya zona bening masing-masing dengan Rf 0,4 pada bakteri Staphylococcus aureus dan Escherichia coli. Senyawa yang berperan sebagai antibakteri terhadap bakteri Staphylococcus aureus dan Escherichia coli diduga adalah senyawa saponin dimana terbentuk warna ungu dengan pereaksi SbCl3.

PERANCANGAN PENGEMBANGAN DIGITAL LIBRARY BERBASIS WEB RESPONSIVE

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Tri Listyorini

2015-04-01

Full Text Available ABSTRAK E-book merupakan cara praktis untuk membaca sebuah buku. E-book bisa kita akses melalui laptop, komputer, maupun smartphone. Dalam penelitian kali ini Digital Library mengambil studi kasus pada Fakultas teknik merupakan salah satu fakultas yang ada di Universitas Muria Kudus yang ingin menjembatani dosen dan mahasiswa agar tidak bingung untuk mencari referensi buku yang dicari. Oleh karena itu Digital Library sangat dibutuhkan. Konsep Digital Library yang akan dibuat ini adalah berisi E-book dari bidang ilmu dari fakultas teknik. Dan agar dapat diakses menggunakan bermacam-macam gadget, maka Digital Library ini akan dikembangkan dengan konsep web Responsif. Dengan metode web Responsif ini tampilan dari Digital Library dapat menyesuaikan gadget yang digunakan dan mudah di akses oleh semua kalangan khususnya di fakultas teknik Universitas Muria Kudus. Hasil yang diharapkan dalam penelitian ini adalah sebuah Digital Library berbasis web Responsif, yang dapat digunakan untuk memberikan kemudahan dalam memperoleh E-book, jurnal dan sebagainya. Kata kunci: E-book, web responsif, digital library.

STATUS INTRODUKSI IKAN DAN STRATEGI PELAKSANAAN SECARA BERKELANJUTAN DI PERAIRAN UMUM DARATAN DI INDONESIA

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Chairulwan Umar

2013-11-01

Full Text Available Masuknya jenis ikan asing berpotensi merubah keseimbangan pada perairan umum daratan, dan di Indonesia gejala ini sudah mulai terlihat. Makalah ini bertujuan untuk membahas lebih lanjut tentang perkembangan introduksi ikan asing, strategi pelaksanaan intoduksi dan berbagai dampaknya terhadap komunitas ikan asli perairan di Indonesia. Penelitian dilakukan melalui penelusuran dan studi pustaka tentang: sejarah kegiatan introduksi ikan yang dilakukan ke Indonesia, jenis-ikan introduksi ikan di Indonesia dan kegiatan introduksi ikan yang telah dan dilakukan di Indonesia beserta dampaknya. Verifikasi lapangan dilakukan pada tahun 2011 di beberapa danau dan waduk antara lain Danau Sentani, Danau Kerinci, Danau Matano dan Waduk Riam Kanan. Data yang terkumpul ditabulasi dan dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa introduksi ikan asing dilakukan di Indonesia sebelum tahun 1900. Introduksi ikan yang telah dilakukan selama ini, lebih banyak dilakukan tanpa melalui kajian ilmiah yang mendalam dan telah terbukti mengakibatkan hilang atau berkurangnya populasi ikan asli atau endemik serta menjadi agen pembawa penyakit. The entry of alien fish species could potentially change the balance of the inland waters and in Indonesia this symptoms was shown. The paper aims are to discuss more about the development introduction of alien fish species, the introduction implementation strategy and its impact to indigenous fish species communities in Indonesian inland waters. The study was conducted through a literature research about: the history of fish introductions activities which carried out in Indonesia, the species of fish introduction in Indonesia and the activities of introduction fish that have been conducted in Indonesia and its impact. Field verification was conducted in 2011 at several lakes and reservoir such us: Sentani Lake, Kerinci Lake, Matano Lake and Riam Kanan Reservoir. The collected data were tabulated and analyzed

Kajian Beberapa Tumbuhan Obat Yang Digunakan Dalam Pengobatan Malaria Secara Tradisional

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Ira Indriaty Paskalita Bule Sopi

2017-02-01

tradisional anti malaria yang teruji secara ilmiah. Masih banyaknya masyarakat yang menggunakan pengobatan tradisional untuk penyembuhan penyakit menunjukkan masih kuatnya tradisi masyarakat dalam hal pencaharian pengobatan. Tujuan penulisan adalah untuk menggambarkan tumbuhan obat yang dimanfaatkan dalam pengobatan tradisional anti malaria. Metode dilakukan melalui tinjauan literatur dengan penelusuran dan pengumpulan data dari berbagai referensi mengenai tumbuhan obat yang dimanfaatkan dalam pengobatan tradisional anti malaria. Data yang telah terkumpul kemudian dideskripsikan menjadi suatu informasi yang menggambarkan jenis tumbuhan obat tradisional dan hasil uji tumbuhan obat. Terdapat beberapa tanaman yang diuji yaitu daun pohon kapur (Harmsiopanax aculeatus Harms, buah merah (Pandanus conoideus Lam., benalu mangga (Dendrophthoe pentandra, manggis (Garcinia mangostana Linn., cempedak (Artocarpus champedem, buah sirih (Piper betle (L. R. Br, mundu (Garcinia dulcis Kurz, dan bunga matahari (Helianthus annuus L.. Dari hasil yang diperoleh menunjukan kandungan senyawa aktif yang terdapat pada jenis tumbuhan obat tersebut telah teruji dalam pengobatan tradisional anti malaria.Kata Kunci : Tumbuhan, obat, tradisional, malaria

The activity and the development of radioecology marine laboratory in Indonesia

International Nuclear Information System (INIS)

Lubis, E.; Umbara, H.; Yarbaini, S.; Unandjar, G.

1999-01-01

The activities in the field of marine radioecology in Indonesia are spreading in many government institutions and more focused in terrestrial. In this paper, beside the RML proposed is explained also the radioecology studies at NPP candidate site of Muria Peninsula during fiscal year 1997 - 1998 are reported

Audit Secara Prospektif terhadap Antimicrobial Stewardship Program pada Pasien Kanker Payudara di RSUP Dr. M. Djamil Padang

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Yelly Oktavia Sari

2017-12-01

Full Text Available Pembedahan yang digunakan sebagai bagian dari pengobatan kanker payudara memiliki potensi risiko infeksi karena pengaruh flora normal pada tubuh dan udara di lingkungan rawat inap. Keefektifan suatu antibiotik dipengaruhi oleh resistensi bakteri terhadap antibiotik. Tujuan penelitian ini untuk mengetahui pola bakteri, pola sensitifitas antibiotik dan pola penggunaan antibiotik pada pasien kanker payudara di bangsal bedah RSUP Dr. M. Djamil Padang pada bulan April - September 2017. Penelitian ini dilakukan secara prospektif menggunakan metode observasi yang bersifat deskriptif. Pola bakteri pada pasien ditemukan Staphylococcus aureus dan Klebsiella sp. sedangkan pada udara ditemukan bakteri Staphylococcus aureus, Staphylococcus epidermidis dan Klebsiella sp. Berdasarkan pola sensitifitas bakteri terhadap antibiotik  selama bulan April-Mei 2017 maka yang tergolong baik (>80% adalah amoksisilin/asam klavulanat dan meropenem sementara pada bulan Agustus-September 2017 adalah meropenem. Pola sensitifitas bakteri udara selama bulan April-Mei 2017 tidak ditemukan yang tergolong baik sedangkan pada bulan Agustus-September 2017 adalah gentamisin, siprofloksasin dan meropenem. Dari total pasien sebanyak 32 orang, yang memenuhi kriteria inklusi hanya 7 orang pasien. Pola penggunaan antibiotik terbanyak pada pasien adalah seftriakson dengan jumlah 7(77,8% dan terjadi perubahan pola sensitifitas antibiotik seftriakson pada bulan April - Mei 2017 yaitu sensitif (66,7% menjadi (33,3% pada bulan Agustus-September 2017. Evaluasi kerasionalan penggunaan antibiotik, diperoleh 6(66,7% tepat obat, 9(100% tepat dosis, 7(77,8% tepat lama pemberian 9(100% tepat rute,7(100% tepat pasien dan 4(45,1% tepat indikasi serta potensi interaksi obat sebanyak 1(14,3% yaitu potensi minor.

Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus

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Harbison Carole E

2007-02-01

Full Text Available Abstract Background Coronaviruses are an important cause of infectious diseases in humans, including severe acute respiratory syndrome (SARS, and have the continued potential for emergence from animal species. A major factor in the host range of a coronavirus is its receptor utilization on host cells. In many cases, coronavirus-receptor interactions are well understood. However, a notable exception is the receptor utilization by group 3 coronaviruses, including avian infectious bronchitis virus (IBV. Feline aminopeptidase N (fAPN serves as a functional receptor for most group 1 coronaviruses including feline infectious peritonitis virus (FIPV, canine coronavirus, transmissible gastroenteritis virus (TGEV, and human coronavirus 229E (HCoV-229E. A recent report has also suggested a role for fAPN during IBV entry (Miguel B, Pharr GT, Wang C: The role of feline aminopeptidase N as a receptor for infectious bronchitis virus. Brief review. Arch Virol 2002, 147:2047–2056. Results Here we show that, whereas both transient transfection and constitutive expression of fAPN on BHK-21 cells can rescue FIPV and TGEV infection in non-permissive BHK cells, fAPN expression does not rescue infection by the prototype IBV strain Mass41. To account for the previous suggestion that fAPN could serve as an IBV receptor, we show that feline cells can be infected with the prototype strain of IBV (Mass 41, but with low susceptibility compared to primary chick kidney cells. We also show that BHK-21 cells are slightly susceptible to certain IBV strains, including Ark99, Ark_DPI, CA99, and Iowa97 ( Conclusion We conclude that fAPN is not a functional receptor for IBV, the identity of which is currently under investigation.

Evaluation of a risk index for advanced proximal neoplasia of the colon.

Science.gov (United States)

Ruco, Arlinda; Stock, David; Hilsden, Robert J; McGregor, S Elizabeth; Paszat, Lawrence F; Saskin, Refik; Rabeneck, Linda

2015-01-01

A clinical risk index that uses distal colorectal findings at flexible sigmoidoscopy (FS) in conjunction with easily determined risk factors for advanced proximal neoplasia (APN) may be useful for tailoring or prioritizing screening with colonoscopy. To conduct an external evaluation of a previously published risk index in a large, well-characterized cohort. Cross-sectional. Teaching hospital and colorectal cancer screening center. A total of 5139 asymptomatic persons aged 50 to 74 (54.9% women) with a mean age (±SD) of 58.3 (±6.2) years. Between 2003 and 2011, all participants underwent a complete screening colonoscopy and removal of all polyps. Participants were classified as low, intermediate, or high risk for APN, based on their composite risk index scores. The concordance or c-statistic was used to measure discriminating ability of the risk index. A total of 167 persons (3.2%) had APN. The prevalence of those with APN among low-, intermediate-, and high-risk categories was 2.1%, 2.9%, and 6.5%, respectively. High-risk individuals were 3.2 times more likely to have APN compared with those in the low-risk category. The index did not discriminate well between those in the low- and intermediate-risk categories. The c-statistic for the overall index was 0.62 (95% confidence interval, 0.58-0.66). Distal colorectal findings were derived from colonoscopies and not FS itself. The risk index discriminated between those at low risk and those at high risk, but it had limited ability to discriminate between low- and intermediate-risk categories for prevalent APN. Information on other risk factors may be needed to tailor, or prioritize, access to screening colonoscopy. Copyright © 2015 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

KARAKTERISASI DAN EVALUASI POPULASI ABALON Haliotis squamata SECARA MOLEKULER, MORFOMETRIK, DAN BIOLOGI

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Gusti Ngurah Permana

2017-10-01

Full Text Available Abalon merupakan salah satu komoditas penting gastropoda laut. Tingginya permintaan abalon ini mengakibatkan menipisnya stok di alam. Oleh karena itu, upaya keberhasilan budidaya abalon perlu didukung oleh jenis unggul. Indikasi awal suatu jenis unggul dapat dilakukan dengan menganalisis potensi genetik yang dimiliki. Penelitian ini dilakukan dengan analisis gen 16S rRNA, karakter morfolologi, dan biologi dianalisis secara deskriptif dengan metode kajian pustaka. Hasil yang diperoleh menunjukkan keragaman inter populasi Haliotis squamata mendeteksi adanya tujuh haplotipe yang terbagi dalam dua kelompok. Penyertaan H. diversicolor sebagai outgroup dalam pengujian memperlihatkan bahwa populasi H. squamata dari Pulau Bali dan beberapa lokasi di Pulau Jawa berada dalam satu kelompok yang terpisah dengan outgroup. Hasil ini kongruen dengan analisis morfometrik terdapat perkembangan pertumbuhan cangkang yang asimetri pada populasi Banten. Pertumbuhan asimetri merupakan indikasi spesifik untuk populasi Banten atau merupakan gejala abnormalitas yang dapat diakibatkan oleh faktor penurunan kualitas genetik atau lingkungan. Karakter biologi terlihat proporsi daging dan gonad berbeda pada populasi Banten dengan indikasi adanya pertumbuhan asimetri. Rasio gonad dan daging populasi Banyuwangi berbeda nyata (P<0,05 dengan populasi lainnya. Abalone is arguably one of the highly valued and sought-after marine gastropods. However, the over-exploitation of this species has exhausted its wild stock. To overcome this challenge, the culture technique and management of this species must be established and continually improved. One of the ways is through producing superior broodstocks. An initial assessment of a genetically superior broodstock can be done using the potential genetic analysis. This recent research employed the analysis to study the species’ 16S rRNA gene. To complement the study, the morphometric and biological characteristics of the species were

Prognostic significance of aberrantly silenced ANPEP expression in prostate cancer

DEFF Research Database (Denmark)

Sørensen, Karina Dalsgaard; Abildgaard, Mette Opstrup; Haldrup, Christa

2013-01-01

Background:Novel biomarkers for prostate cancer (PC) are urgently needed. This study investigates the expression, epigenetic regulation, and prognostic potential of ANPEP in PC.Methods:Aminopeptidase N (APN; encoded by ANPEP) expression was analysed by immunohistochemistry using tissue microarrays...... in three hypermethylated prostate cell lines, suggesting epigenetic silencing. Negative APN immunoreactivity was significantly associated with short RFS and short CSS in the RP and CT cohort, respectively, independently of routine clinicopathological predictors. Combining APN with a known angiogenesis...... representing 267 radical prostatectomy (RP) and 111 conservatively treated (CT) PC patients. Clinical end points were recurrence-free survival (RFS) and cancer-specific survival (CSS), respectively. The ANPEP promoter methylation levels were determined by bisulphite sequencing or MethyLight analysis in 278...

Observations of atmosphere-biosphere exchange of total and speciated peroxynitrates: nitrogen fluxes and biogenic sources of peroxynitrates

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K.-E. Min

2012-10-01

Full Text Available Peroxynitrates are responsible for global scale transport of reactive nitrogen. Recent laboratory observations suggest that they may also play an important role in delivery of nutrients to plant canopies. We measured eddy covariance fluxes of total peroxynitrates (ΣPNs and three individual peroxynitrates (APNs ≡ PAN + PPN + MPAN over a ponderosa pine forest during the Biosphere Effects on AeRosols and Photochemistry EXperiment 2009 (BEARPEX 2009. Concentrations of these species were also measured at multiple heights above and within the canopy. While the above-canopy daytime concentrations are nearly identical for ΣPNs and APNs, we observed the downward flux of ΣPNs to be 30–60% slower than the flux of APNs. The vertical concentration gradients of ΣPNs and APNs vary with time of day and exhibit different temperature dependencies. These differences can be explained by the production of peroxynitrates other than PAN, PPN, and MPAN within the canopy (presumably as a consequence of biogenic VOC emissions and upward fluxes of these PN species. The impact of this implied peroxynitrate flux on the interpretation of NO_x fluxes and ecosystem N exchange is discussed.

Detection of parenchymal abnormalities in experimentally induced acute pyelonephritis in rabbits using contrast-enhanced ultrasonography, CT, and MRI

Energy Technology Data Exchange (ETDEWEB)

Ryu, Jeong Ah; Kim, Bo Hyun; Kim, Seung Kwon; Seo, Jin Won [Dept. of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Kim, Jong Sung [Laboratory Animal Research Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

2016-12-15

We evaluated the efficacy of contrast-enhanced ultrasonography (CEUS) in detecting acute pyelonephritis (APN) using the rabbit kidney model and compared it with CT and MRI. This study was approved by the Institutional Review Board. In a total of 20 New Zealand White rabbits, APN was induced experimentally. CEUS, CT, and MRI were performed on the first, third, and seventh postoperative days. After imaging studies, the subjects were sacrificed and the pathological diagnosis of APN was confirmed in each animal by a pathologist. Imaging studies were obtained in eight animals, including eight CEUS, four computed tomography (CT), and four magnetic resonance imaging (MRI) images. CEUS depicted diffuse renal enlargement (7), diffuse heterogeneous parenchymal enhancement (6), and focal areas of decreased parenchymal enhancement (6). These findings were well correlated with the CT and MRI findings in five cases in which these studies were available. CT and MRI showed diffuse renal enlargement, diffuse heterogeneous parenchymal enhancement, focal areas of decreased parenchymal enhancement, focal contour bulging, and the finding of perinephric spread of infection. In a rabbit model, CEUS could depict the parenchymal lesions of APN similar to CT or MRI; however, it was limited in depicting the perinephric extension of inflammation.

Exploration of priority actions for strengthening the role of nurses in achieving universal health coverage

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Rowaida Al Maaitah

Full Text Available ABSTRACT Objective: to explore priority actions for strengthening the role of Advanced Practice Nurses (APNs towards the achievement of Universal Health Converge (UHC as perceived by health key informants in Jordan. Methods: an exploratory qualitative design, using a semi-structured survey, was utilized. A purposive sample of seventeen key informants from various nursing and health care sectors was recruited for the purpose of the study. Content analysis utilizing the five-stage framework approach was used for data analysis. Results: the findings revealed that policy and regulation, nursing education, research, and workforce were identified as the main elements that influence the role of APNs in contributing to the achievement of UHC. Priority actions were identified by the participants for the main four elements. Conclusion: study findings confirm the need to strengthen the role of APNs to achieve UHC through a major transformation in nursing education, practice, research, leadership, and regulatory system. Nurses should unite to come up with solid nursing competencies related to APNs, PHC, UHC, leadership and policy making to strengthen their position as main actors in influencing the health care system and evidence creation.

バージニア大学における高度専門看護師 (APN) 教育に関する調査報告

OpenAIRE

正木, 治恵; 眞嶋, 朋子; 佐藤, まゆみ; 石井, 邦子

2008-01-01

看護学研究科における高度専門職養成教育のあり方を検討するための基礎資料として,米国の高度専門看護師 (APN : Advanced Practice Nurse) 教育に関する調査を行った.情報提供者は同大学院の教員,大学病院における臨床指導者,大学院生であった.調査項目は,バージニア大学大学院教育課程全体の概要,APNの理論的枠組み,老人看護,急性期看護(クリティカルケア,がん看護を含む),助産師教育,NP(Nurse Practitioner)教育およびDNP (Doctor of Nursing Practice) 教育,臨床指導の概要,大学病院におけるAPNの役割の実際についてである.米国では,NP,CNS (Clinical Nurse Specialist), CNM (Certified Nurse-Midwife), CRNA (Certified Registered Nurse Anesthetist) を総称してAPNとし,2年間の修士課程において養成するものとしている.このように統合した経緯には,実践現場でCNSとNPの役割を統合するような能力や役割が求め...

Avaliação da escala de Epworth em pacientes com a Síndrome da apnéia e hipopnéia obstrutiva do sono Evaluation of Epworth Sleepiness Scale in patients with obstructive sleep apnea-hypopnea syndrome

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Letícia Boari

2004-12-01

Full Text Available A síndrome da apnéia e hipopnéia obstrutiva do sono (SAHOS é, atualmente, considerada um problema de saúde pública por causar aumento da morbi-mortalidade cardiovascular e acidentes de trânsito. A polissonografia assistida é o padrão-ouro para o diagnóstico e acompanhamento destes pacientes. No entanto, por ser onerosa, demorada e de acesso restrito, outros métodos tem sido desenvolvidos. A escala de sonolência de Epworth (ESE é uma avaliação subjetiva, porém, rápida, sem custos e simples de ser aplicada. OBJETIVO: Avaliar a correlação entre a pontuação da ESE e o índice de apnéia e hipopnéia (IAH da polissonografia de pacientes com SAHOS. FORMA DE ESTUDO: Clínico retrospectivo. MATERIAL E MÉTODO: Revisão de prontuário de 66 pacientes com queixa de roncopatia que foram submetidos a procedimento cirúrgico (uvulopalatofaringoplastia com ou sem abordagem nasal. Avaliaram-se a pontuação da ESE e o IAH da polissonografia pré e pós-operatórios. RESULTADOS: 78,7% pacientes com grau normal de IAH tiveram pontuação de ESE menor do que 10 e 65% pacientes com grau severo de IAH tiveram pontuação maior do que 10. Não houve resultados estatisticamente significantes para os grupos moderado e leve. CONCLUSÃO: A escala de Epworth pode distinguir os graus normais e severos sem, no entanto, determinar os graus moderado e leve. Assim, pode ser utilizada para acompanhamento de pacientes com SAHOS sem, no entanto, substituir a polissonografia uma vez que não consegue avaliar todos os graus de severidade.Today obstructive sleep apnea–hypopnea syndrome (OSAHS is a public health issue, since it increases cardiovascular morbidity-mortality rate and the risk of car crashes. Overnight polysomnography is the gold standard for diagnosis and follow-up of affected patients. However, because the test is expensive, time-consuming and of difficult access, others methods have been proposed. Although the Epworth Sleepiness Scale (ESS is

Diagnostic role of initial renal cortical scintigraphy in children with the first episode of acute pyelonephritis

International Nuclear Information System (INIS)

Jaksic, E.; Bogdanovic, R.; Artiko, V.

2011-01-01

Assessment of the first febrile urinary tract infection (UTI) in children has been the subject of debate for many years. Diagnosis of acute pyelonephritis (APN) is usually based on clinical and biological data. The clinical usefulness of early Tc-99m dimercaptosuccinic acid (DMSA) scintigraphy remains controversial, although it may influence the type and duration of treatment. The aim of this study was to assess the role of initial cortical scintigraphy in the detection of early renal parenchymal damage in children highly suspected of having APN and to compare the scintigraphic findings with selected clinical/laboratory parameters and ultrasonography. A prospective study was conducted in 34 infants and young children (18 boys, 16 girls), aged 1.5-36 months (mean 9.8±8.7 months), hospitalized with a first episode of clinically suspected APN. Within the first 5 days after admission, Tc-99m DMSA renal scintigraphy, ultrasonography (US), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), white blood cell count (WBC) and urine analyses were performed. DMSA scintigraphy showed changes consistent with APN in 27/34 (79%) patients, with a mean age of 10.9 months, including 12 males (44%) and 15 (56%) females. Out of 9 febrile children with negative urine culture and supportive evidence of UTI, scintigraphy showed parenchymal involvement in 8 children (24% in the whole group, 30% in scintigraphically documented APN). There were no statistically significant correlations between the frequency or size of the initial scintigraphic abnormalities and age, sex, body temperature, CRP levels or ESR. A CRP level of >54 mg/L and a WBC of >13,300/mm 3 had sensitivities of 56 and 59% and specificities of 86 and 71%, respectively. US showed changes consistent with APN in 7/34 (21%) in the whole group and in 7/27 (26%) patients with positive cortical scan (p<0.05). Initial DMSA renal scintigraphy is a sensitive method for the early diagnosis of APN in young children and is

PRODUK BENANG SUTRA BERKUALITAS MELALUI TEKNIK SERIKULTUR DENGAN PAKAN YANG DIKEMBANGKAN SECARA IN VITRO

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Faradilla Faradilla

2018-01-01

Full Text Available Samarinda woven sarong is typical sarong of Samarinda. This sarong is still using silk spun silk raw material imported from Tiongkok. The development of aquaculture is needed to obtain local silk threads in order to help to reduce production costs in the samarinda silk industry. The high quality mulberry plants are needed to support silkworm cultivation (sericulture. The qualified mulberry plants are obtained by in vitro culture techniques. The objective of this study is to obtain mulberry leaf (Morus Sp free from disease, uniform, and to obtain quality silk threads through sericulture techniques with feeds that were propagated in vitro. The research stages consist of sterilization, Murashige and Skoog (MS media, sub culture, observation of data analysis fund. The design used is Completely Randomized Design with single factor, ie BAP concentration (control, 0.5 mg / l, 1 mg / l and 2 mg / l. Each treatment is repeated 8 times. The results showed that administration of ZPT 2 mg / l at age 4 MST gives the best response for all observed variables. The use of ZPT BAP with various concentrations produces the germination rate, shoot height, number of shoots and number of different leaves. All treatments are unsuccessful in inducing roots. Keywords: in vitro; Murbei; Sericulture Sarung tenun samarinda adalah sarung khas kota Samarinda. Sarung ini masih menggunakan bahan baku sutera jenis spun silk yang diimpor dari Tiongkok. Pengembangan serikultur diperlukan untuk mendapatkan benang sutera lokal. Sehingga membantu mengurangi biaya produksi dalam industri persuteraan samarinda. Tanaman murbei yang berkualitas diperlukan untuk menunjang budidaya ulat sutera (serikultur. Tanaman murbei yang berkualitas diperoleh dengan teknik kultur in vitro. Tujuan penelitian adalah memperoleh daun murbei (Morus Sp yang bebas penyakit dan seragam serta memperoleh benang sutera berkualitas melalui teknik serikultur dengan pakan yan diperbanyak secara in vitro. Tahapan

PERMODELAN PENGELOLAAN WILAYAH PESISIR DAN PULAU-PULAU KECIL SECARA TERPADU YANG BERBASIS MASYARAKAT (STUDI KASUS PULAU RAAS KABUPATEN SUMENEP MADURA

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Adi Waluyo

2013-04-01

Full Text Available Negara Indonesia adalah negara maritim yang memiliki banyak pulau baik yang bernama maupun yang belum bernama. Salah satunya adalah pulau Raas Madura, dimana pulau ini memiliki sumber daya alam yang melimpah di sepanjang garis pantainya. Dibalik melimpahnya sumber daya alam tersebut masih terdapat masyarakat yang sebagian besar prasejahtera. Pemanfaatan yang berlebih (over exploitation dan krisis ekonomi yang menyebabkan terjadinya persaingan untuk memperoleh sumber daya alam yang tersisa sehingga mengakibatkan terjadinya degradasi sumber daya alam. Sistem pengelolaan wilayah pesisir dan pulau-pulau kecil yang secara terpadu yang dapat mengatisipasi terjadinya degradasi sumber daya alam tersebut. Upaya ini harus didukung oleh pemerintah untuk memberikan kesejahteraan mayarakat di darah pesisir di pulau-pulau kecil. Kata kunci : sumber daya alam, Over exploitation, degradasi, pengelolaan terpadu MODELLING OF COMMUNITY BASED INTEGRATED COASTAL AND SMALL ISLAND MANAGEMENT (CASE STUDY OF RAAS ISLAND SUMENEP DISTRICT MADURA Indonesia is a maritime nation consists of small islands. One of them is the Raas island of Madura. This island has abundant natural resources along its coastline however most of the population lives under the poverty line. Over exploitation of fisheries resources and economic crisis caused competition to obtain the remaining of natural resources resulting in the degradation of natural resources. Integrated coastal and small island management is expected to prevent the degradation. This effort should be supported by the government in order to provide prosperity for the coastal community.Key words : natural resources, over exploitation, degradation, integrated management

HARMONI KEHIDUPAN SOSIAL BEDA AGAMA DAN ALIRAN DI KUDUS

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Moh Rosyid

2015-11-01

secara bersama-sama antara warga, tokoh, dan perangkat pemerintahan. Warga mayoritas tidak mudah tersulut pemberitaan media dan gosip yang tertebar setiap saat untuk menerkam yang minoritas. Terwujudnya toleransi beragama antar dan intern umat beragama dapat dilakukan dengan mengoptimalkan pendekatan budaya dan keharmonisan sosial. Dengan demikian, pendekatan yang menggunakan aspek keamanan secara alami ternafikan. Kata Kunci: Nirkonflik, Antar Umat dan Intern Umat Beragama, Aliran Agama. HARMONY OF SOCIAL LIFE OF DIFFERENT RELIGION IN KUDUS. Internal and interreligious conflict has colored social reality in this country. The most important thing to solve the problem is finding its fundamental cause. However, religious life among the society does not necessarily mean conflict or religious differences is not identical with conflict. Research conducted 2012 in Colo Village, Dawe, Kudus, Central Java shows that people from different religious background has created harmony among themselves. This research uses observation and interview to collect data from the research field and applies descriptive qualitative analysis. In 2012 the population in Colo is 4.327 people consisting of 2.400 family in which the majority are Moslem. There are also 16 Christians, 40 Buddhists and 14 Ahmadiyahs family living in one village. All religious adherents build their own sacred places consisting of five mosques (the Muria Mosque in Muria Mountain built by the Central Java Provincial government, two mosques in Colo village and a mosque built by Ahmady people, 11 mushalla (Muslim prayer house spread in four hamlet of Colo, a church beside a vihara. The vihara was built during Gus Durs presidency. In addition, there are two private Islamic schools, two elementary schools, a private junior Islamic high school (MTs, a private senior Islamic high school (MA, three Quranic learning centers, a kindergarten and an Islamic playgroup. Religious harmony among the society in Colo is established through

Effector/memory CD8+ T cells synergize with co-stimulation competent macrophages to trigger autoimmune peripheral neuropathy.

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Yang, Mu; Shi, Xiang Qun; Peyret, Corentin; Oladiran, Oladayo; Wu, Sonia; Chambon, Julien; Fournier, Sylvie; Zhang, Ji

2018-04-05

Autoimmune peripheral neuropathy (APN) such as Guillain Barre Syndrome (GBS) is a debilitating illness and sometimes life threatening. The molecular and cellular mechanisms remain elusive but exposure to environmental factors including viral/bacterial infection and injury is highly associated with disease incidence. We demonstrated previously that both male and female B7.2 (CD86) transgenic L31 and L31/CD4KO mice develop spontaneous APN. Here we further reveal that CD8 + T cells in these mice exhibit an effector/memory phenotype, which bears a resemblance to the CD8 + T cell response following persistent cytomegalovirus (CMV) infection in humans and mice, whilst CMV has been considered as one of the most relevant pathogens in APN development. These activated, peripheral myelin Ag specific CD8 + T cells are required for the disease initiation. While an injury to a peripheral nerve results in Wallerian degeneration in control littermates, the same injury accelerates the development of APN in other non-injured nerves of L31 mice which have a predisposed inflammatory background consisting of effector/memory CD8 + T (CD8 + T EM ) cells. However, CD8 + T EM cells alone are not sufficient. A certain threshold of B7.2 expression on nerve macrophages is an additional requisite. Our findings reveal that indeed, the synergism between CD8 + T EM cells and co-stimulation competent macrophages is crucial in inducing autoimmune-mediated peripheral neuropathy. The identification of decisive molecular/cellular players connecting environmental triggers and the occurrence of APN provides opportunities to prevent disease onset, reduce relapses and develop new therapeutic strategies. Crown Copyright © 2018. Published by Elsevier Inc. All rights reserved.

Evaluation of intestinal phosphate binding to improve the safety profile of oral sodium phosphate bowel cleansing.

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Stef Robijn

Full Text Available Prior to colonoscopy, bowel cleansing is performed for which frequently oral sodium phosphate (OSP is used. OSP results in significant hyperphosphatemia and cases of acute kidney injury (AKI referred to as acute phosphate nephropathy (APN; characterized by nephrocalcinosis are reported after OSP use, which led to a US-FDA warning. To improve the safety profile of OSP, it was evaluated whether the side-effects of OSP could be prevented with intestinal phosphate binders. Hereto a Wistar rat model of APN was developed. OSP administration (2 times 1.2 g phosphate by gavage with a 12h time interval induced bowel cleansing (severe diarrhea and significant hyperphosphatemia (21.79 ± 5.07 mg/dl 6h after the second OSP dose versus 8.44 ± 0.97 mg/dl at baseline. Concomitantly, serum PTH levels increased fivefold and FGF-23 levels showed a threefold increase, while serum calcium levels significantly decreased from 11.29 ± 0.53 mg/dl at baseline to 8.68 ± 0.79 mg/dl after OSP. OSP administration induced weaker NaPi-2a staining along the apical proximal tubular membrane. APN was induced: serum creatinine increased (1.5 times baseline and nephrocalcinosis developed (increased renal calcium and phosphate content and calcium phosphate deposits on Von Kossa stained kidney sections. Intestinal phosphate binding (lanthanum carbonate or aluminum hydroxide was not able to attenuate the OSP induced side-effects. In conclusion, a clinically relevant rat model of APN was developed. Animals showed increased serum phosphate levels similar to those reported in humans and developed APN. No evidence was found for an improved safety profile of OSP by using intestinal phosphate binders.

Intimate partner violence: advanced practice nurses clinical stories of success and challenge.

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Brykczynski, Karen A; Crane, Patricia; Medina, Cindy K; Pedraza, Dora

2011-03-01

This qualitative study presents knowledge from clinical experiences of advanced practice nurses (APNs) working with women who have experienced intimate partner violence (IPV). Face-to-face interviews were conducted with ten APNs to discover their ways of being with, supporting, and helping women who have experienced IPV. Interviews were transcribed and analyzed using interpretive phenomenology. Analysis proceeded from whole to parts and back to whole with ongoing attention to maintaining the situational context to guide interpretation of meanings. APNs experience both challenges and successes in caring for women who live with IPV. Findings consist of interpretations of clinical stories to uncover knowledge embedded in practice. Healing practices and ways of being survival facilitators for women and children are identified and described. APNs are in a unique position to help families who live with abuse, but may lack resources and knowledge about the most effective interventions. They may become cynical and frustrated with feelings of futility when faced with the repeating patterns associated with the cycle of violence. The goals of this study are to promote more comprehensive understanding of IPV and stimulate changes in education, practice, research, and health policy. ©2011 The Author(s) Journal compilation © 2011 American Academy of Nurse Practitioners.

Advanced practice nursing for enduring health needs management: a global perspective.

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Koskinen, Liisa; Mikkonen, Irma; Graham, Iain; Norman, Linda D; Richardson, Jim; Savage, Eileen; Schorn, Mavis

2012-07-01

Advanced practice nursing expertise has been acknowledged worldwide as one response to the challenges arising from changes in society and health care. The roots of advanced practice nursing education are at the University of Colorado where the first known programme started in 1965. In many countries advanced practice nurses (APNs) have taken responsibility for routine patient care formerly carried out by physicians in order to reduce their workload. However, more and more, APNs have taken responsibility for new service areas and quality programmes not previously provided. Chronic disease management is one of these new service areas because long-term diseases are increasingly challenging service systems globally. This article is based on an international APN partnership. The aim of the article is to describe how the partnership will design a 15 ECTS credit course on Enduring Health Need Management as a cross-cultural collaborative endeavour. The adaptation of an inquiry based learning framework will be described drawing on four main principles of the theory: authentic learning communities; student encouragement in analysing gradually more complicated problems; networking in knowledge creation and; student engagement and activity. The cross-cultural online course aims to increase APNs' intercultural competence as well as their global and international work orientation. Copyright © 2011 Elsevier Ltd. All rights reserved.

Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells.

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Han, Sora; Jeong, Ae Lee; Lee, Sunyi; Park, Jeong Su; Kim, Kwang Dong; Choi, Inpyo; Yoon, Suk Ran; Lee, Myung Sok; Lim, Jong-Seok; Han, Seung Hyun; Yoon, Do Young; Yang, Young

2013-05-01

Previously, we found that adiponectin (APN) suppresses IL-2-induced NK cell activation by downregulating the expression of the IFN-γ-inducible TNF-related apoptosis-inducing ligand and Fas ligand. Although the antitumor function of APN has been reported in several types of solid tumors, with few controversial results, no lymphoma studies have been conducted. In this study, we assessed the role of APN in immune cell function, including NK cells, CTLs, and myeloid-derived suppressor cells, in EL4 and B16F10 tumor-bearing APN knockout (KO) mice. We observed attenuated EL4 growth in the APNKO mice. Increased numbers of splenic NK cells and splenic CTLs were identified under naive conditions and EL4-challenged conditions, respectively. In APNKO mice, splenic NK cells showed enhanced cytotoxicity with and without IL-2 stimulation. Additionally, there were decreased levels of myeloid-derived suppressor cell accumulation in the EL4-bearing APNKO mice. Enforced MHC class I expression on B16F10 cells led to attenuated growth of these tumors in APNKO mice. Thus, our results suggest that EL4 regression in APNKO mice is not only due to an enhanced antitumor immune response but also to a high level of MHC class I expression.

Commentary: Taking the Pulse on the Integration of the Clinical Nurse Specialist Role in Canada.

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Roussel, Josette

2016-01-01

The Canadian Nurses Association (CNA) is pleased to provide this update on the integration of the clinical nurse specialist (CNS) role in Canada. Many advances have occurred since the publication of the Canadian Journal of Nursing Leadership special issue focused on advanced practice nursing (APN) in 2010. The CNA continues to promote and advance this APN role, and views the CNS as an essential and critical role for better care to Canadians.

Identification of Hypertension Management-related Errors in a Personal Digital Assistant-based Clinical Log for Nurses in Advanced Practice Nurse Training

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Nam-Ju Lee, DNSc, RN

2010-03-01

Conclusion: The Hypertension Diagnosis and Management Error Taxonomy was useful for identifying errors based on documentation in a clinical log. The results provide an initial understanding of the nature of errors associated with hypertension diagnosis and management of nurses in APN training. The information gained from this study can contribute to educational interventions that promote APN competencies in identification and management of hypertension as well as overall patient safety and informatics competencies.

Results of a five-year study of 99mTc DMSA renal scintigraphy in children and adolescents following acute pyelonephritis

International Nuclear Information System (INIS)

Chroustova, D.; Palyzova, D.; Kolska, M.; Urbanova, I.

2006-01-01

Renal scintigraphy, generally using 99' mTc-DMSA, is the accepted reference standard for detection of renal cortical changes. The timing of the test, i.e., whether an acute 99m Tc-DMSA scan, a follow-up only or both scans should be performed, however, remains open to discussion. In our study, a six-month follow- up DMSA scan was performed in all the children diagnosed with a first attack of acute pyelonephritis (APN) in two large paediatric clinics of Charles University's 3 rd School of Medicine in Prague during a five-year period. All diagnoses were confirmed by a paediatric nephrologist. 382 children (267 girls, 115 boys) aged between 7 months and 19 years were included in the study. For analytical purposes, the patients were divided into 4 age groups: I - less than 1 year of age, II - 1-5 years, III - 5-10 years, and IV - 10-19 years. In all children younger than five years, a micturition cystourethrogram (MCUG) for detection of vesicoureteric reflux (VUR) was performed between one and three months after the APN episode. Static renal scintigraphy, using an HR collimator with parallel holes was performed using a planar Gamma camera MB 9200 (Gamma Budapest) in all children six months after APN, with a complement of pinhole images, SPECT or PSPECT of the kidneys. 1. In group I, all four children with positive VUR on MCUG had a pathological DMSA scan, while only two of the 32 patients with negative VUR had a pathological DMSA. 2. In group II, 17 children had VUR on MCUG, six of them with a pathological and 11 with a normal DMSA scan. Most of the 221 children without VUR had a normal DMSA scintigraphy; pathological findings were present in 17 children only. 3. In group III, all children with VUR, but only 5 out of 53 without VUR, had a pathological DMSA scan. 4. Five out of 50 children in group IV had a pathological DMSA. APN occurred most frequently in group II (62.3%, or 238 children) and ranged between 10-15% in the remaining groups. APN was found very frequently

The valuation of 99Tcm-DMSA renal cortical scintigraphy for prediction of renal scarring in children with acute pyelonephritis

International Nuclear Information System (INIS)

Zhao Ruifang; Ji Zhiying; Lv Xiaomei; Wu Ha; Li Yiwei; Gu Fanlei; Zhao Xiaofei

2009-01-01

Objective: Acute pyelonephritis (APN) is a common infectious disease in childhood. APN may result in ineversible renal scarring. 99 Tc m -dimercaptsuccinic (DMSA) renal cortical scintigraphy was reported to be highly sensitive and specific for detection APN and renal scarring. The aim of this study was to determine the incidence of renal scarring in a group of children with APN and to evaluate the relative factors at risk of scarring using 99 Tc m -DMSA renal cortical scintigraphy. Methods: One hundred and eighteen patients (44 males, 74 females, age range: 1 month to 14 years) with APN underwent DMSA renal cortical scan before treatment and six month after treatment to identify renal damage and renal scarring. The degree of renal damage was divided to grade I to IV. A directed radionuclide cystography (DRC) was performed in 72 cases to evaluate vesicoureteric reflux (VUR). Statistical analysis between all those relative factors was performed using Spearman grading relational analysis. The software was SPSS 11.5. Results: The follow-up renal cortical scan revealed that 79 normal kidneys on first scan remained normal; of 64 kidneys with grade I damage, 7.81% (5/64) developed renal scar; of 51 kidneys with grade II, 49.02% (25/51) developed renal scar; of 19 with grade III, 68.42% (13/19) developed renal scar; of 23 with grade IV, 100.00% (23/23) developed renal scar. There was a significant relationship between the incidence of renal scar on follow-up and the grade of renal damage on first scan (r=0.877, P<0.01). VUR was found in 54.17% (78/144) per renal unit. Only 4.55% (3/66) of those with non-refluxing ureters developed renal scars on follow-up. One of four patients with mild-refluxing ureters developed renal scars. 46.51% (20/43) of those with moderate-refluxing ureters developed renal scars. 87.10% (27/31) of those with severe-refluxing ureters developed renal scars. There was a significant relationship between the incidence of renal scarring in follow-up and

Gerontology found me: gaining understanding of advanced practice nurses in geriatrics.

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Campbell-Detrixhe, Dia D; Grassley, Jane S; Zeigler, Vicki L

2013-10-01

Examining the meanings of the experiences of advanced practice nurses (APNs) who chose to work with older adults and why they continue to work with this population was the focus of this hermeneutic qualitative research study. Twelve geriatric APNs currently practicing in two South Central states were interviewed using an open-ended interview guide. Using Gadamerian hermeneutics, the researchers identified Gerontology Found Me as the significant expression that reflected the fundamental meaning of the experience as a whole. Four themes emerged that further described the meanings of the participants' personal, educational, and professional experiences: Becoming a Gerontology Nurse, Being a Gerontology Nurse, Belonging to Gerontology, and Bringing Others to Gerontology. This study concluded that APNs' personal and professional experiences were more influential than educational experiences to become geriatric nurses, and having these personal and professional experiences of being in relationship with older individuals further contributed to their choice of gerontology.

A latency analysis for M2M and OG-like traffic patterns in different HSPA core network configurations

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M. V. Popović

2014-11-01

Full Text Available In this paper we present an analysis intended to reveal possible impacts of core network features on latency for modelled M2M and Online Gaming traffic. Simulations were performed in a live 3G/HSPA network. Test traffic simulating multiplayer real-time games and M2M applications was generated on 10 mobile phones in parallel, sending data to a remote server. APNs with different combinations of hardware and features (proxy server, different GGSNs and firewalls, usage of Service Awareness feature were chosen. The traffic was recorded on the Gn interface in the mobile core. The goal of experiments was to evaluate any eventually significant variation of average recorded RTTs in the core part of mobile network that would clearly indicate either the impact of used APN on delay for a specific traffic pattern, or selectivity of the APN towards different traffic patterns.

VISUALISASI DESAIN GEOMETRIK JALAN SECARA 3D BERDASARKAN PERHITUNGAN ALINYEMEN HORISONTAL DAN ALINYEMEN VERTIKAL

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A. Arif Dwi Nugroho

2005-01-01

Full Text Available Highway geometric design is a part of highway planning which focused on physical form planning, so it can fulfil the highway basic function. Highway geometric design consists of horizontal alignment and vertical alignment and each of them has its own calculation. Computer technology developments can produce softwares which is able to help and simplify the calculations of both alignments and the softwares also can produce designs which visualize the calciulation into 2D images. But 2D image is not real enough to imagine the realistic form of the highway. We need 3D visualisation to imagine the realistic highway. This paper explains how the system can produce the 3D visualisation from horizontal alignment and vertical alignment calculations. First, find the highway 3D position in the 3D coordinate. 3D coordinate has three component, x, y and z axis. From horizontal alignment calculation, we get the x and y value and from vertical alignment, we get the z value. After obtaining the 3D position, then the highway design can be drawn. This software can design the highway better because it can simulate the highway wether it is comfort enough to be passed. Abstract in Bahasa Indonesia : Desain geometrik jalan merupakan bagian dari perencanaan jalan yang dititik-beratkan pada perencanaan bentuk fisik sehingga dapat memenuhi fungsi dasar dari jalan. Desain geometrik jalan terdiri dari Alinyemen Horisontal dan Alinyemen Vertikal, dan masing-masingnya memiliki perhitungan tersendiri. Dengan adanya kemajuan teknologi komputer, mampu menghasilkan program komputer yang dapat membantu dan menyederhanakan perhitungan dari masing-masing alinyemen tersebut serta menghasilkan rancangan yang sesuai dengan kaidah yang berlaku, bahkan mampu membuat visualisasi dua dimensi dari rancangan tersebut. Namun visualisasi dua dimensi dirasa kurang mampu memberi gambaran secara nyata bentuk asli dari rancangan geometrik jalan. Oleh karena itu dalam penelitian yang dilakukan ini

Pembentukan mother plant Bacopa australis secara In-vitro dan aklimatisasi dalam aquascape air tawar

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Media Fitri Isma Nugraha

2017-12-01

Full Text Available Tanaman air adalah bagian penting dari ekosistem air tawar. Salah satu spesies yang terkenal adalah Bacopa australis. Hobiis aquascape saat ini memiliki ketertarikan tinggi terhadap tanaman air dengan kualitas yang bagus dari setiap spesiesnya. Metode perbanyakan tanaman air tanpa tanah, lahan pertanian dan air perlu dilakukan untuk memenuhi keinginan tersebut. Tujuan dari penelitian ini adalah untuk mendapatkan formula media kultur jaringan dan zat pengatur tumbuh yang tepat untuk multiplikasi dalam perakitan mother plant (tanaman induk Bacopa australis, serta mendapatkan media terbaik untuk aklimatisasi. Media yang digunakan adalah media Murashige dan Skoog (MS A padat dengan perbedaan konsentrasi zat pengatur tumbuh. Perlakuan uji dalam kombinasi zat pengatur tumbuh (a 0,50 mg/L BAP + 0,50 mg/L kinetin; (b 0,50 mg/L BAP; dan (c 0,50 mg/L 2,4-D. Aklimatisasi tanaman induk dilakukan pada berbagai media antara lain 1 pasir silika + pupuk aqua soil amazonia, 2. pasir malang + pupuk aqua soil amazonia, 3 pasir silika + pupuk cair; 4 pasir malang + pupuk. Hasil yang diperoleh, yaitu formula media kultur terbaik untuk multiplikasi tunas tanaman B. australis secara in-vitro adalah media MS (A yang diperkaya dengan 0,5 mg/L BAP + 0,5 mg/L kinetin, sedangkan aklimatisasi terbaik pada media pasir malang + pupuk aqua soil amazonia. Water plant is an important part of freshwater ecosystems. One of the famous species is Bacopa australis. Today, many aquascape hobbyists have a high interest in aquatic plant species that have good aesthetic appearances. To answer this challenge, a new method in-vitro propagation of aquatic plants, planted without soil, agricultural land and water was conducted. The aim of this research was to find the best growth regulator hormon formula and aclimatisation medium, in creating the mother plant Bacopa australis. The medium used was MS (Murashige and Skoog, 1974 with different growth regulator hormon, i.e: (a 0.50 mg L-1 BAP

Communication latencies of Apple push notification messages relevant for delivery of time-critical information to anesthesia providers.

Science.gov (United States)

Rothman, Brian S; Dexter, Franklin; Epstein, Richard H

2013-08-01

Tablet computers and smart phones have gained popularity in anesthesia departments for educational and patient care purposes. VigiVU(™) is an iOS application developed at Vanderbilt University for remote viewing of perioperative information, including text message notifications delivered via the Apple Push Notification (APN) service. In this study, we assessed the reliability of the APN service. Custom software was written to send a message every minute to iOS devices (iPad(®), iPod Touch(®), and iPhone(®)) via wireless local area network (WLAN) and cellular pathways 24 hours a day over a 4-month period. Transmission and receipt times were recorded and batched by days, with latencies calculated as their differences. The mean, SEM, and the exact 95% upper confidence limits for the percent of days with ≥1 prolonged (>100 seconds) latency were calculated. Acceptable performance was defined as mean latency 100 seconds. Testing conditions included fixed locations of devices in high signal strength locations. Mean latencies were 173,000 iPad and iPod latencies, none were >100 seconds. For iPhone latencies, 0.03% ± 0.01% were >100 seconds. The 95% upper confidence limits of days with ≥1 prolonged latency were 42% (iPhone) and 5% to 8% (iPad, iPod). The APN service was reliable for all studied devices over WLAN and cellular pathways, and performance was better than third party paging systems using Internet connections previously investigated using the same criteria. However, since our study was a best-case assessment, testing is required at individual sites considering use of this technology for critical messaging. Furthermore, since the APN service may fail due to Internet or service provider disruptions, a backup paging system is recommended if the APN service were to be used for critical messaging.

[Use of physical assessment skills and education needs of advanced practice nurses and nurse specialists].

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Shin, Hyunsook; Kim, Bog-Ja; Kang, Hee Sun

2009-10-01

The study was done to investigate physical assessment skills used by, and educational needs of, advanced practice nurses (APNs) and nurse specialists in Korea. A total of 123 APNs and nurse specialists working in five major hospitals in Seoul were surveyed from July 15 to August 20, 2007. Fourteen skills out of 126 items were reported as being performed on a regular basis by participants. The majority of these skills involved general observation. Forty-six skills were rarely used. Some participants showed a lack of confidence in certain assessment skills, such as in doing a rectal or pelvic exam, and the use of some assessment equipment. Over 90% of participants required in-depth education on health assessment provided by specialists or nursing professional organizations. More educational opportunities in physical assessment should be provided including education programs based on the nurses' skill levels and needs. This effort will help to increase confidence of APNs and nurse specialists in physical assessment skills, ultimately resulting in better nursing outcomes.

Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice.

Science.gov (United States)

Aozuka, Yasushi; Koizumi, Keiichi; Saitoh, Yurika; Ueda, Yasuji; Sakurai, Hiroaki; Saiki, Ikuo

2004-12-08

We investigated the effect of bestatin, an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B, on the angiogenesis induced by B16-BL6 melanoma cells. Oral administration of bestatin (100-200 mg/kg/day) was found to significantly inhibit the melanoma cell-induced angiogenesis in a mouse dorsal air sac assay. Additionally, anti-APN/CD13 mAb (WM15), which neutralizes the aminopeptidase activity in tumor cells, as well as bestatin inhibited the tube-like formation of human umbilical vein endothelial cells (HUVECs) in vitro. Furthermore, the intraperitoneal administration of bestatin (50-100 mg/kg/day) after the orthotopic implantation of B16-BL6 melanoma cells into mice reduced the number of vessels oriented towards the established primary tumor mass on the dorsal side of mice. These findings suggest that bestatin is an active anti-angiogenic agent that may inhibit tumor angiogenesis in vivo and tube-like formation of endothelial cells in vitro through its inhibition of APN/CD13 activity.

Studi Eksperimental Pengaruh Penambahan Disturbance Body Terhadap Karakteristik Aliran Yang Melintasi Sebuah Silinder Sirkular Yang Tersusun Secara Tandem Dalam Saluran Sempit ”Studi Kasus Untuk Disturbance Body Berulir Dan Polos Dengan Rasio Diameter D

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Pratista Hariyanto

2012-09-01

Full Text Available Penelitian ini bertujuan untuk mempelajari aliran yang melintasi silinder sirkular yang tersusun tandem yang ditempatkan pada saluran sempit. Adapun penelitian ini juga berusaha untuk mereduksi gaya hambat yang terjadi dengan menggunakan sebuah disturbance body yang memiliki rasio yang d/D=0.1dengan kondisi permukaan polos dan berulir dengan rasio jarap gap L/D = 2.0. Penelitian ini dilakukan secara eksperimental dengan cara meletakkan silinder sirkular (D= 37.5mm dalam sebuah terowongan udara saluran sempit berpenampang bujur sangkar (h=125mm dengan bilangan Reynolds sebesar 1.16x102 (berdasarkan diameter hidrolis saluran dan kecepatan freestream. Tekanan diukur dengan pressure tap yang terpasang pada permukaan silinder sirkular dan pada test section terowongan angin (inlet dan outlet. Sedangkan profil kecepatan aliran didapatkan dengan menggunakan pitot static tube yang dipasang dibelakang silinder sirkular.

Structure-Guided, Single-Point Modifications in the Phosphinic Dipeptide Structure Yield Highly Potent and Selective Inhibitors of Neutral Aminopeptidases

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Vassiliou, Stamatia; Węglarz-Tomczak, Ewelina; Berlicki, Łukasz; Pawełczak, Małgorzata; Nocek, Bogusław; Mulligan, Rory; Joachimiak, Andrzej; Mucha, Artur

2014-10-09

Seven crystal structures of alanyl aminopeptidase from Neisseria meningitides (the etiological agent of meningitis, NmAPN) complexed with organophosphorus compounds were resolved to determine the optimal inhibitor-enzyme interactions. The enantiomeric phosphonic acid analogs of Leu and hPhe, which correspond to the P1 amino acid residues of well-processed substrates, were used to assess the impact of the absolute configuration and the stereospecific hydrogen bond network formed between the aminophosphonate polar head and the active site residues on the binding affinity. For the hPhe analog, an imperfect stereochemical complementarity could be overcome by incorporating an appropriate P1 side chain. The constitution of P1'-extended structures was rationally designed and the lead, phosphinic dipeptide hPhePψ[CH2]Phe, was modified in a single position. Introducing a heteroatom/heteroatom-based fragment to either the P1 or P1' residue required new synthetic pathways. The compounds in the refined structure were low nanomolar and subnanomolar inhibitors of N. meningitides, porcine and human APNs, and the reference leucine aminopeptidase (LAP). The unnatural phosphinic dipeptide analogs exhibited a high affinity for monozinc APNs associated with a reasonable selectivity versus dizinc LAP. Another set of crystal structures containing the NmAPN dipeptide ligand were used to verify and to confirm the predicted binding modes; furthermore, novel contacts, which were promising for inhibitor development, were identified, including a π-π stacking interaction between a pyridine ring and Tyr372.

Efficacy of parenteral administration of bee venom in experimental arthritis in the rat: a comparison with methotrexate.

Science.gov (United States)

Yamasaki, Simone C; Mendes, Mariana T; Alponti, Rafaela F; Silveira, Paulo F

2015-05-01

The use of bee venom (BV) to treat inflammation and pain in arthritis has become increasingly common. This study aimed to compare the effects of BV and methotrexate (MTX), the most used disease-modifying anti-rheumatic drug, in arthritic rats. Edema, erythema, cyanosis, hyperalgesia, reduction of the body mass gain, high circulating tumor necrosis factor alpha (TNF-α) and anti-type II collagen antibodies (AACII), and altered activity of basic (APB) and neutral (APN) aminopeptidases and dipeptidyl peptidase IV (DPPIV) are present in arthritic rats. MTX and/or BV do not affect AACII in healthy or arthritic individuals, but restores TNF-α to normal levels in arthritic rats. BV restores body mass gain to normal levels and MTX ameliorates body mass gain. BV contains DPPIV. BV restores APN in synovial fluid (SF) and in soluble fraction (S) from synovial tissue (ST), and DPPIV in solubilized membrane-bound fraction (M) from peripheral blood mononuclear cells (PBMCs). MTX restores APN of SF, as well as ameliorates APB of S-PBMCs, APN of S-ST and DPPIV of M-PBMCs. The combination therapy does not overcome the effects of BV or MTX alone on the peptidase activities. Edema is ameliorated by MTX or BV alone. MTX, but not BV, is effective in reducing hyperalgesia. Data show that anti-arthritic effects of BV at non-acupoints are not negligible when compared with MTX. Copyright © 2015 Elsevier Ltd. All rights reserved.

Focused development of advanced practice nurse roles for specific patient groups in a Swiss university hospital

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Spichiger, Elisabeth; Zumstein-Shaha, Maya; Schubert, Maria; Herrmann, Luzia

2018-02-01

Background: To cover future health care needs of the population, new care models are necessary. The development of advanced nursing practice (ANP) offers the opportunity to meet these challenges with novel services. At the Inselspital, Bern University Hospital, ANP services and corresponding advanced practice nurse (APN) roles have been developed since 2011. Purpose: The aim is to develop innovative and evidence based ANP services to supplement health care for specific patient groups and their family members with the goal to improve safety and achieve better outcomes. Methods: Project-based ANP services are developed in close collaboration of clinical departments and the Nursing Development Unit (NDU) of the Directorate of Nursing. Structure, process and outcome data are collected for evaluation. Findings: Currently, five ANP services are established and running, eight more are in the developmental phase. Most services address the long term care of patients with chronic illnesses and their family members. Ten APNs work between 10 % and 80 %, three are leading an ANP-team. APNs work over 50 % in direct clinical practice, primarily in counselling. An ANP network connects APNs and NDU, promoting synergy and exchange. Conclusions: The available resources often constitute a challenge for the development of ANP services. Vital for the long-term success are an adequate extent of the position, the support by department directorate, the conceptual framework that is implemented across the whole hospital, and the development within project structures.

Positioning your business in the marketplace.

Science.gov (United States)

Lachman, V D

1996-01-01

Marketing the quality, cost-effective service delivered by advanced practice nurses (APNs) requires savvy in marketing principles. The basic principles of market segmentation: target (niche) marketing; and the four Ps of marketing mix--product, price, promotion, and place. The marketing process is presented along with examples. APNs' ability to successfully market their skills requires that they "position" themselves in the prospective buyer's mind. After a brief description of the customer's mind-set, the focus shifts specifically to promotion--marketing in action. Numerous no-cost/low-cost ideas are included.

Department of the Navy Justification of Estimates for Fiscal Year 1985. Submitted to Congress February 1984. Procurement, Aircraft Procurement, Navy

Science.gov (United States)

1984-02-01

j~r_ f i1~ -A’s OSI 14. 8 ProJect Finannial Plan (Cont’d): FY 1289 TOTAL Qty cost Qty Cost APN-5 223 $20,934 0&HN Install. (41) $4$54 2,605 APN-6...ATS) AMD Design Changes -W - 4-0 1_ _ OSI ? 11-84 Description/Justification (Cont’d): ALQ-126 Support Assembly Addition of Latching Relay to BRU-33 BRU...Activity 5 Modification Title and No.: Night Vision (OSIP 39-85) Modelo of Aircraft Affected: HII-IK Description/Justification: In order to improve tactical

A atenção pré-natal na ótica de um grupo de mulheres usuárias do subsetor suplementar La atención prenatal en la óptica de un grupo de mujeres usuarias del subsector suplementar Prenatal care attention in the view of a group of women who use the supplementary subsector

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Micheli Regina Etges

2011-03-01

Full Text Available Este estudo, de abordagem qualitativa, objetivou conhecer a percepção de mulheres que vivenciaram a Atenção Pré-Natal (APN no contexto do Subsetor Suplementar (SS sobre a qualidade desta atenção. Os dados foram coletados através de entrevistas semi-estruturadas e analisados por categorização descritiva. Para as entrevistadas, a APN foi de qualidade, suprindo suas necessidades e expectativas. Acolhimento, vínculo com o profissional, a consequente segurança transmitida e a duração das consultas foram critérios destacados nesta avaliação. Suas experiências sugerem que a APN realizada no SS segue, em parte, as recomendações do Ministério da Saúde (MS e da Organização Mundial da Saúde (OMS. A freqüência das consultas e as orientações fornecidas são aspectos condizentes ao que se recomenda. Os dados sugerem, contudo, que a APN não segue a orientação do MS e da OMS para que seja evitado o uso excessivo de tecnologias duras, como é o caso das ecografias obstétricas.Este estudio, de abordaje cualitativo, objetivó conocer la percepción de mujeres que vivenciaron la Atención Prenatal (APN en el contexto del Subsector Suplementar (SS sobre la calidad de esta atención. Los datos fueron recolectados a través de entrevistas semiestructuradas y analizados por categorización descriptiva. Para las entrevistadas, la APN fue de calidad, supliendo sus necesidades y expectativas. Acogida, vínculo con el profesional, la consecuente seguridad trasmitida y la duración de las consultas fueron criterios destacados en esta evaluación. Sus experiencias sugestionan que la APN realizada en el SS sigue, en parte, las recomendaciones del Ministerio de la Salud (MS y Organización Mundial de la Salud (OMS. La frecuencia de las consultas y las orientaciones fornecidas son aspectos coherentes a lo que se recomienda. Los datos sugestionan, con todo, que la APN no sigue la orientación del MS y de la OMS para que sea evitado el uso

PENUNDAAN PEMBERIAN PAKAN ARTEMIATERHADAP PERFORMANSI BENIH IKAN COBIA (Rachycentron canadum YANG DIPELIHARA SECARA TERKONTROL

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Titiek Aslianti

2016-11-01

Full Text Available Upaya kontinuitas produksi benih ikan cobia, Rachycentron canadum telah dilakukan namun besarnya biaya operasional dalam penggunaan artemia sebagai pakan masih menjadi faktor pembatas. Oleh karena itu, perlu dilakukan penelitian penundaan pemberian artemia dengan tujuan untuk mengetahui waktu yang tepat saat awal diberikan artemia sehingga penggunaannya efektif dan efisien. Penelitian dilakukan dengan menggunakan wadah berupa bak fiber (1 m3 berjumlah 9 unit yang diisi telur cobia sebanyak 3.000 butir/bak dan larva dipelihara hingga mencapai ukuran benih (± 3 cm/umur 20 hari. Rancangan penelitian adalah acak lengkap yang terdiri atas 3 perlakuan yaitu perbedaan waktu awal pemberian artemia yakni pada larva (A umur 5 hari; (B umur 10 hari; dan (C umur 15 hari. Masing-masing perlakuan diulang 3 kali. Data pertumbuhan dan sintasan dianalisis menggunakan sidik ragam. Performansi fisik dan perkembangan tulang belakang diamati sebagai data pendukung. Hasil penelitian menunjukkan bahwa pertumbuhan panjang, bobot, ataupun sintasan di antara perlakuan secara statistik tidak menunjukkan perbedaan yang nyata (P>0,05. Namun pemberian artemia pada larva umur 5 hari (perlakuan A menghasilkan pertumbuhan panjang (28 mm dan bobot badan (74,067 mg serta sintasan (12,07% relatif lebih tinggi daripada perlakuan B ataupun C. Penundaan pemberian artemia lebih dari 5 hari justru menghasilkan benih yang bertumbuh lebih lambat dan banyak mengalami kematian. Hasil pengamatan terhadap perkembangan tulang belakang pada semua perlakuan tidak menunjukkan performansi tulang belakang yang abnormal.  The effort to guarantee a sustainable seed production of cobia, Rachycentron canadum have been carried out but the weight of operational cost in the use of artemia as food has been a problem. The aim of the experiment was to describe the exact and effective time for the initial feeding of seed of cobia using Artemia nauplii. Nine concrete tanks with 1 m3 capacity were stocked

Mindfulness-Based Stress Reduction in Advanced Nursing Practice: A Nonpharmacologic Approach to Health Promotion, Chronic Disease Management, and Symptom Control.

Science.gov (United States)

Williams, Hants; Simmons, Leigh Ann; Tanabe, Paula

2015-09-01

The aim of this article is to discuss how advanced practice nurses (APNs) can incorporate mindfulness-based stress reduction (MBSR) as a nonpharmacologic clinical tool in their practice. Over the last 30 years, patients and providers have increasingly used complementary and holistic therapies for the nonpharmacologic management of acute and chronic diseases. Mindfulness-based interventions, specifically MBSR, have been tested and applied within a variety of patient populations. There is strong evidence to support that the use of MBSR can improve a range of biological and psychological outcomes in a variety of medical illnesses, including acute and chronic pain, hypertension, and disease prevention. This article will review the many ways APNs can incorporate MBSR approaches for health promotion and disease/symptom management into their practice. We conclude with a discussion of how nurses can obtain training and certification in MBSR. Given the significant and growing literature supporting the use of MBSR in the prevention and treatment of chronic disease, increased attention on how APNs can incorporate MBSR into clinical practice is necessary. © The Author(s) 2015.

A structural insight into the P1S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases

Energy Technology Data Exchange (ETDEWEB)

Węglarz-Tomczak, Ewelina; Berlicki, Łukasz; Pawełczak, Małgorzata; Nocek, Bogusław; Joachimiak, Andrzej; Mucha, Artur

2016-07-01

N0 -substituted 1,2-diaminoethylphosphonic acids and 1,2-diaminoethylphosphinic dipeptides were explored to unveil the structural context of the unexpected selectivity of these inhibitors of M1 alanine aminopeptidases (APNs) versus M17 leucine aminopeptidase (LAP). The diaminophosphonic acids were obtained via aziridines in an improved synthetic procedure that was further expanded for the phosphinic pseudodipeptide system. The inhibitory activity, measured for three M1 and one M17 metalloaminopeptidases of different sources (bacterial, human and porcine), revealed several potent compounds (e.g., Ki ¼ 65 nM of 1u for HsAPN). Two structures of an M1 representative (APN from Neisseria meningitidis) in complex with N-benzyl-1,2-diaminoethylphosphonic acid and N-cyclohexyl-1,2- diaminoethylphosphonic acid were determined by the X-ray crystallography. The analysis of these structures and the models of the phosphonic acid complexes of the human ortholog provided an insight into the role of the additional amino group and the hydrophobic substituents of the ligands within the S1 active site region.

Perbandingan Efektivitas Daya Hambat Kotrimoksazol Generik dan Paten terhadap Pertumbuhan Bakteri Escherichia coli sebagai Penyebab Infeksi Saluran Kemih secara In Vitro

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Puti Anggun Sari

2015-01-01

Full Text Available AbstrakInfeksi saluran kemih merupakan salah satu infeksi yang sering ditemukan setelah infeksi saluran napas. Penyebab terbanyak infeksi saluran kemih adalah Escherichia coli. Kotrimoksazol merupakan kombinasi dari dua obat yaitu trimetoprim dan sulfametoksazol serta salah satu contoh antibiotik yang merupakan first-line therapy untuk infeksi saluran kemih. Kotrimoksazol terbagi menjadi dua jenis obat yaitu obat generik dan paten. Akan tetapi, belakangan ini penggunaan obat generik mulai menurun di masyarakat dan masyarakat cenderung meragukan kualitasnya. Padahal masyarakat yang akan diuntungkan jika mengetahui mutu obat generik tidak kalah dengan obat paten. Tujuan dari penelitian ini adalah untuk membandingkan efektivitas daya hambat kotrimoksazol generik dan paten terhadap pertumbuhan bakteri Escherichia coli sebagai penyebab infeksi saluran kemih secara in vitro. Penelitian ini merupakan penelitian analitik eksperimental dengan desain cross-sectional study. Penelitian ini menggunakan 19 sampel isolat bakteri dari pasien infeksi saluran kemih yang disebabkan oleh Escherichia coli di RSUP Dr. M. Djamil yang ditentukan rumus minimal adequate sample size menggunakan metode difusi cakram dan dilihat perbandingan antara zona bebas kuman yang dibentuk oleh obat generik dan paten tersebut. Data yang diperoleh akan diolah secara statistik dengan uji hipotesis t-independent test. Hasil penelitian menunjukkan bahwa pada 17 sampel tidak didapatkan zona bebas kuman baik pada kotrimoksazol generik atau paten. Sedangkan pada 2 sampel lainnya didapatkan zona bebas kuman pada kedua obat kotrimoksazol generik dan paten. Setelah dilakukan analisis statistik menggunakan SPSS dengan uji t-independent test didapatkan bahwa tidak terdapat perbedaan bermakna antara sensitivitas bakteri Escherichia coli penyebab infeksi saluran kemih terhadap kotrimoksazol generik dan paten. Sedangkan resistensi yang terjadi pada 17 sampel lain diduga disebabkan penggunaan

A descriptive study of employment patterns and work environment outcomes of specialist nurses in Canada.

Science.gov (United States)

Doran, Diane; Duffield, Christine; Rizk, Paul; Nahm, Sang; Chu, Charlene H

2014-01-01

The purpose was to describe the number, demographic characteristics, work patterns, exit rates, and work perceptions of nurses in Ontario, Canada, in 4 specialty classifications: advanced practice nurse (APN)-clinical nurse specialist (CNS), APN-other, primary healthcare nurse practitioner [RN(extended class [EC])], and registered nurse (RN) with specialty certification. The objectives were to (1) describe how many qualified nurses are available by specialty class; (2) create a demographic profile of specialist nurses; (3) determine the proportions of specialist and nonspecialist nurses who leave (a) direct patient care and (b) nursing practice annually; (4) determine whether specialist and nonspecialist nurses differ in their self-ratings of work environment, job satisfaction, and intention to remain in nursing. Employment patterns refer to nurses' employment status (eg, full-time, part-time, casual), work duration (ie, length of employment in nurses and in current role), and work transitions (ie, movement in and out of the nursing workforce, and movement out of current role). A longitudinal analysis of the Ontario nurses' registration database from 2005 to 2010 and a survey of specialist nurses in Canada was conducted. The setting was Canada. The database sample consisted of 3 specialist groups, consisting of RN(EC), CNS, and APN-other, as well as 1 nonspecialist RN staff nurse group. The survey sample involved 359 nurses who were classified into groups based on self-reported job title and RN specialty-certification status. Data sources included College of Nurses of Ontario registration database and survey data. The study measures were the Nursing Work Index, a 4-item measure of job satisfaction, and 1-item measure of intent to leave current job. Nurses registered with the College of Nurses of Ontario were tracked over the study period to identify changes in their employment status with comparisons made between nurses employed in specialist roles and those

The Influence of atmospheric conditions to probabilistic calculation of impact of radiology accident on PWR 1000 MWe

International Nuclear Information System (INIS)

Pande Made Udiyani; Sri Kuntjoro

2015-01-01

The calculation of the radiological impact of the fission products releases due to potential accidents that may occur in the PWR (Pressurized Water Reactor) is required in a probabilistic. The atmospheric conditions greatly contribute to the dispersion of radionuclides in the environment, so that in this study will be analyzed the influence of atmospheric conditions on probabilistic calculation of the reactor accidents consequences. The objective of this study is to conduct an analysis of the influence of atmospheric conditions based on meteorological input data models on the radiological consequences of PWR 1000 MWe accidents. Simulations using PC-Cosyma code with probabilistic calculations mode, the meteorological data input executed cyclic and stratified, the meteorological input data are executed in the cyclic and stratified, and simulated in Muria Peninsula and Serang Coastal. Meteorological data were taken every hour for the duration of the year. The result showed that the cumulative frequency for the same input models for Serang coastal is higher than the Muria Peninsula. For the same site, cumulative frequency on cyclic input models is higher than stratified models. The cyclic models provide flexibility in determining the level of accuracy of calculations and do not require reference data compared to stratified models. The use of cyclic and stratified models involving large amounts of data and calculation repetition will improve the accuracy of statistical calculation values. (author)

Cervical cancer screening in adolescents: an evidence-based internet education program for practice improvement among advanced practice nurses.

Science.gov (United States)

Choma, Kim; McKeever, Amy E

2015-02-01

The literature reports great variation in the knowledge levels and application of the recent changes of cervical cancer screening guidelines into clinical practice. Evidence-based screening guidelines for the prevention and early detection of cervical cancer offers healthcare providers the opportunity to improve practice patterns among female adolescents by decreasing psychological distress as well as reducing healthcare costs and morbidities associated with over-screening. The purpose of this pilot intervention study was to determine the effects of a Web-based continuing education unit (CEU) program on advanced practice nurses' (APNs) knowledge of current cervical cancer screening evidence-based recommendations and their application in practice. This paper presents a process improvement project as an example of a way to disseminate updated evidence-based practice guidelines among busy healthcare providers. This Web-based CEU program was developed, piloted, and evaluated specifically for APNs. The program addressed their knowledge level of cervical cancer and its relationship with high-risk human papillomavirus. It also addressed the new cervical cancer screening guidelines and the application of those guidelines into clinical practice. Results of the study indicated that knowledge gaps exist among APNs about cervical cancer screening in adolescents. However, when provided with a CEU educational intervention, APNs' knowledge levels increased and their self-reported clinical practice behaviors changed in accordance with the new cervical cancer screening guidelines. Providing convenient and readily accessible up-to-date electronic content that provides CEU enhances the adoption of clinical practice guidelines, thereby decreasing the potential of the morbidities associated with over-screening for cervical cancer in adolescents and young women. © 2014 Sigma Theta Tau International.

Chimeric Feline Coronaviruses That Encode Type II Spike Protein on Type I Genetic Background Display Accelerated Viral Growth and Altered Receptor Usage▿

Science.gov (United States)

Tekes, Gergely; Hofmann-Lehmann, Regina; Bank-Wolf, Barbara; Maier, Reinhard; Thiel, Heinz-Jürgen; Thiel, Volker

2010-01-01

Persistent infection of domestic cats with feline coronaviruses (FCoVs) can lead to a highly lethal, immunopathological disease termed feline infectious peritonitis (FIP). Interestingly, there are two serotypes, type I and type II FCoVs, that can cause both persistent infection and FIP, even though their main determinant of host cell tropism, the spike (S) protein, is of different phylogeny and displays limited sequence identity. In cell culture, however, there are apparent differences. Type II FCoVs can be propagated to high titers by employing feline aminopeptidase N (fAPN) as a cellular receptor, whereas the propagation of type I FCoVs is usually difficult, and the involvement of fAPN as a receptor is controversial. In this study we have analyzed the phenotypes of recombinant FCoVs that are based on the genetic background of type I FCoV strain Black but encode the type II FCoV strain 79-1146 S protein. Our data demonstrate that recombinant FCoVs expressing a type II FCoV S protein acquire the ability to efficiently use fAPN for host cell entry and corroborate the notion that type I FCoVs use another main host cell receptor. We also observed that recombinant FCoVs display a large-plaque phenotype and, unexpectedly, accelerated growth kinetics indistinguishable from that of type II FCoV strain 79-1146. Thus, the main phenotypic differences for type I and type II FCoVs in cell culture, namely, the growth kinetics and the efficient usage of fAPN as a cellular receptor, can be attributed solely to the FCoV S protein. PMID:19906918

Airway delivery of soluble factors from plastic-adherent bone marrow cells prevents murine asthma.

Science.gov (United States)

Ionescu, Lavinia I; Alphonse, Rajesh S; Arizmendi, Narcy; Morgan, Beverly; Abel, Melanie; Eaton, Farah; Duszyk, Marek; Vliagoftis, Harissios; Aprahamian, Tamar R; Walsh, Kenneth; Thébaud, Bernard

2012-02-01

Asthma affects an estimated 300 million people worldwide and accounts for 1 of 250 deaths and 15 million disability-adjusted life years lost annually. Plastic-adherent bone marrow-derived cell (BMC) administration holds therapeutic promise in regenerative medicine. However, given the low cell engraftment in target organs, including the lung, cell replacement cannot solely account for the reported therapeutic benefits. This suggests that BMCs may act by secreting soluble factors. BMCs also possess antiinflammatory and immunomodulatory properties and may therefore be beneficial for asthma. Our objective was to investigate the therapeutic potential of BMC-secreted factors in murine asthma. In a model of acute and chronic asthma, intranasal instillation of BMC conditioned medium (CdM) prevented airway hyperresponsiveness (AHR) and inflammation. In the chronic asthma model, CdM prevented airway smooth muscle thickening and peribronchial inflammation while restoring blunted salbutamol-induced bronchodilation. CdM reduced lung levels of the T(H)2 inflammatory cytokines IL-4 and IL-13 and increased levels of IL-10. CdM up-regulated an IL-10-induced and IL-10-secreting subset of T regulatory lymphocytes and promoted IL-10 expression by lung macrophages. Adiponectin (APN), an antiinflammatory adipokine found in CdM, prevented AHR, airway smooth muscle thickening, and peribronchial inflammation, whereas the effect of CdM in which APN was neutralized or from APN knock-out mice was attenuated compared with wild-type CdM. Our study provides evidence that BMC-derived soluble factors prevent murine asthma and suggests APN as one of the protective factors. Further identification of BMC-derived factors may hold promise for novel approaches in the treatment of asthma.

Performance of a risk index for advanced proximal colorectal neoplasia among a racially/ethnically diverse patient population (risk index for advanced proximal neoplasia).

Science.gov (United States)

Levitzky, Benjamin E; Brown, Colin C; Heeren, Timothy C; Schroy, Paul C

2011-06-01

Tailoring the use of screening colonoscopy based on the risk of advanced proximal neoplasia (APN) has been advocated as a strategy for reducing demand and optimizing effectiveness. A 7-point index based on age, sex, and distal findings at sigmoidoscopy has been proposed that stratifies individuals into low, intermediate, and high-risk categories. The aim of this cross-sectional analysis was to determine the validity of this index, which was originally derived and validated among mostly whites, for black and Hispanic patients. Data, including age, sex, colonoscopic findings, and pathology, were collected retrospectively from 1,481 white, 1,329 black, and 689 Hispanic asymptomatic, average-risk patients undergoing screening colonoscopy between 2000 and 2005. Cumulative scores ranging from 0 to 7 were derived for each subject and categorized as low, intermediate, or high risk. Rates of APN were assessed for each risk category after stratification by race/ethnicity. Index performance was assessed using the C-statistic and compared across the three racial groups. Rates of APN among patients categorized as low, intermediate, or high risk increased from 1.0 to 2.8 to 3.7% for whites, 1.0 to 2.2 to 4.2% for blacks, and 0.6 to 1.9 to 3.7% for Hispanics. The index performed similarly for all three groups, but showed limited ability to discriminate low from intermediate-risk patients, with C-statistic values of 0.62 for whites, 0.63 for blacks, and 0.68 for Hispanics. A risk index based on age, sex, and distal endoscopic findings has limited ability to discriminate low from intermediate-risk white, black, and Hispanic patients for APN.

Le système d’information sur la biodiversité de l’administration des parcs nationaux argentins

Directory of Open Access Journals (Sweden)

Leonidas Lizarraga

2014-06-01

Full Text Available Introduction Le système d’information sur la biodiversité (SIB, Sistema de Información de Biodiversidad de l’administration des parcs nationaux argentins (APN, Administración de Parques Nacionales a été lancé en 2002, avec le soutien du Global Environment Fund (GEF dans le cadre du Projet de préservation de la biodiversité mené par l’État argentin. Le dispositif, abrégé en SIB-APN, est composé d’un ensemble de bases de données thématiques et d’un système d’information géographique : son ob...

[Renal scarring in children under 36 months hospitalised for acute pyelonephritis].

Science.gov (United States)

Rodríguez Azor, Begoña; Ramos Fernández, José Miguel; Sánchiz Cárdenas, Sonia; Cordón Martínez, Ana; Carazo Gallego, Begoña; Moreno-Pérez, David; Urda Cardona, Antonio

2017-02-01

Acute pyelonephritis (APN) is one of the most common causes of serious bacterial infection in infants. Renal scarring is the most prevalent long-term complication. To review the incidence of renal scarring within 6 months after an episode of APN in children under 36 months and its relationship with imaging studies, clinical settings, and bacteriology. A retrospective study of previously healthy patients aged one to 36 months, admitted for a first episode of APN, with a minimum follow-up of 6 months. Demographic and clinical variables were collected along with bacteriology, renal and bladder ultrasound scan, voiding cystourethrography, DMSA-scintigraphy, and re-infection events. A total of 125 patients were included in the study, of which 60% were male, the large majority (92%) febrile, and due to E. coli (74.6%). There was a history of prenatal ultrasound scan changes in 15.4%. Ultrasound scan found dilation of the urinary tract in 22.1%. Voiding cystourethrography was performed on 70 patients: 54.3% no abnormalities, 12.8% vesicoureteral reflux (VUR) grade i-iii, and 32.9% iv-v grade VUR. Six patients had iv-v grade VUR with a normal ultrasound scan. Adherence to DMSA-scintigraphy at 6 months was only 61% of that indicated. Renal scarring was found in 44.3% of those in which it was performed (60 cases). Almost half (44%) DMSA-scintigraphy in children aged one to 36 months hospitalised for APN show renal scarring at 6 months, which was found to be associated with the re-infection events and the iv-v grade VUR. There was no relationship between scarring and the bacteriology or the elevations of inflammatory biochemical markers. Copyright © 2015 Asociación Española de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

Eddy covariance fluxes of acyl peroxy nitrates (PAN, PPN and MPAN above a Ponderosa pine forest

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G. M. Wolfe

2009-01-01

Full Text Available During the Biosphere Effects on AeRosols and Photochemistry EXperiment 2007 (BEARPEX-2007, we observed eddy covariance (EC fluxes of speciated acyl peroxy nitrates (APNs, including peroxyacetyl nitrate (PAN, peroxypropionyl nitrate (PPN and peroxymethacryloyl nitrate (MPAN, above a Ponderosa pine forest in the western Sierra Nevada. All APN fluxes are net downward during the day, with a median midday PAN exchange velocity of −0.3 cm s⁻¹; nighttime storage-corrected APN EC fluxes are smaller than daytime fluxes but still downward. Analysis with a standard resistance model shows that loss of PAN to the canopy is not controlled by turbulent or molecular diffusion. Stomatal uptake can account for 25 to 50% of the observed downward PAN flux. Vertical gradients in the PAN thermal decomposition (TD rate explain a similar fraction of the flux, suggesting that a significant portion of the PAN flux into the forest results from chemical processes in the canopy. The remaining "unidentified" portion of the net PAN flux (~15% is ascribed to deposition or reactive uptake on non-stomatal surfaces (e.g. leaf cuticles or soil. Shifts in temperature, moisture and ecosystem activity during the summer – fall transition alter the relative contribution of stomatal uptake, non-stomatal uptake and thermochemical gradients to the net PAN flux. Daytime PAN and MPAN exchange velocities are a factor of 3 smaller than those of PPN during the first two weeks of the measurement period, consistent with strong intra-canopy chemical production of PAN and MPAN during this period. Depositional loss of APNs can be 3–21% of the gross gas-phase TD loss depending on temperature. As a source of nitrogen to the biosphere, PAN deposition represents approximately 4–19% of that due to dry deposition of nitric acid at this site.

Enriched environment decreases microglia and brain macrophages inflammatory phenotypes through adiponectin-dependent mechanisms: Relevance to depressive-like behavior.

Science.gov (United States)

Chabry, Joëlle; Nicolas, Sarah; Cazareth, Julie; Murris, Emilie; Guyon, Alice; Glaichenhaus, Nicolas; Heurteaux, Catherine; Petit-Paitel, Agnès

2015-11-01

Regulation of neuroinflammation by glial cells plays a major role in the pathophysiology of major depression. While astrocyte involvement has been well described, the role of microglia is still elusive. Recently, we have shown that Adiponectin (ApN) plays a crucial role in the anxiolytic/antidepressant neurogenesis-independent effects of enriched environment (EE) in mice; however its mechanisms of action within the brain remain unknown. Here, we show that in a murine model of depression induced by chronic corticosterone administration, the hippocampus and the hypothalamus display increased levels of inflammatory cytokines mRNA, which is reversed by EE housing. By combining flow cytometry, cell sorting and q-PCR, we show that microglia from depressive-like mice adopt a pro-inflammatory phenotype characterized by higher expression levels of IL-1β, IL-6, TNF-α and IκB-α mRNAs. EE housing blocks pro-inflammatory cytokine gene induction and promotes arginase 1 mRNA expression in brain-sorted microglia, indicating that EE favors an anti-inflammatory activation state. We show that microglia and brain-macrophages from corticosterone-treated mice adopt differential expression profiles for CCR2, MHC class II and IL-4recα surface markers depending on whether the mice are kept in standard environment or EE. Interestingly, the effects of EE were abolished when cells are isolated from ApN knock-out mouse brains. When injected intra-cerebroventricularly, ApN, whose level is specifically increased in cerebrospinal fluid of depressive mice raised in EE, rescues microglia phenotype, reduces pro-inflammatory cytokine production by microglia and blocks depressive-like behavior in corticosterone-treated mice. Our data suggest that EE-induced ApN increase within the brain regulates microglia and brain macrophages phenotype and activation state, thus reducing neuroinflammation and depressive-like behaviors in mice. Copyright © 2015 Elsevier Inc. All rights reserved.

Genetic polymorphisms in Toll-like receptors among pediatric patients with renal parenchymal infections of different clinical severities.

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Chi-Hui Cheng

Full Text Available BACKGROUND: Although several studies have suggested single gene defects or variations in the genes associated with host immune response could confer differences in susceptibility to urinary pathogen invasion, no studies have examined the genetic polymorphisms in various toll-like receptors (TLRs that activate innate immune responses in pediatric renal parenchymal infections of different clinical severities, namely acute pyelonephritis and the clinically more severe disease, acute lobar nephronia. METHODOLOGY: Patients who fulfilled the diagnostic criteria for acute pyelonephritis (APN and acute lobar nephronia (ALN without underlying diseases or structural anomalies, except for vesicoureteral reflux (VUR, were enrolled. Genotyping of the single nucleotide polymorphisms (SNPs in the genes encoding TLR-1, TLR-2, TLR-4, TLR-5, and TLR-6 was performed by matrix-assisted laser desorption/ionization time-of-flight-based mini-sequencing analysis. PRINCIPAL FINDINGS: A total of 16 SNPs were selected for genotyping. Analysis of 96 normal and 48 patients' samples revealed that only four SNPs had heterozygosity rates >0.01. These SNPs were selected for further investigation. Hardy-Weinberg equilibrium was satisfied for the observed genotype frequencies. Statistically significant differences in the genotype frequency of TLR-2 (rs3804100, T1350C between controls and ALN or (APN+ALN combined group were identified using the recessive model with the correction for multiple-SNP testing. Further genotype pattern frequency analysis in TLR-2 SNPs (rs3804099 and rs3804100 showed significantly reduced occurrence of the rare allele homozygote (CC+CC in the no-VUR subgroup of APN and ALN cases. CONCLUSIONS: As the inflammatory responses in ALN patients are more severe than those in APN patients (higher CRP levels, longer duration of fever after antibiotic treatment, these findings suggest that the genetic variant in TLR-2 (rs3804100, T1350C may protect the host from

Correlation of insulin resistance with serum C-reactive protein, adiponectin and leptin levels in patients with type 2 diabetes

International Nuclear Information System (INIS)

Duan Yangqiang; Wang Zuobing; Yu Hui

2012-01-01

Objective: To explore the relationship between serum C-reactive protein (CRP), adiponectin (APN), leptin (Leptin) levels, insulin resistance index (HOMA-IR) and type 2 diabetes mellitus (T2DM) disease susceptibility. Methods: The plasma leptin and insulin (FINS) levels in the DM patients were determined by RIA, and the serum ANP levels were determined by ELSIA. The CRP, conventional serum fasting plasma glucose (FPG) levels were determine by automatic biochemistry analyzer. The insulin resistance index (HOMA-IR, FPG x FINS/22.5) was calculated. The result was analyzed with normal healthy control group. Results: The serum CRP and leptin, HOMA-IR levels in T2DM group were significantly higher than that of in control group (P< 0.01), and the serum ANP was significantly lower than in control group (P<0.01). The HOMA-IR in T2DM was positively correlated with serum CRP (r= 0.36, P<0.05) and leptin(r= 0.39, P<0.05), and was negatively correlated with serum APN (r=0.32, P<0.05). Conclusion: The high serum CRP and leptin and low APN levels hyperlipidaemia might be factors for diabetes, and their metabolic disorders may be closely related with insulin resistance in patients with type 2 diabetes. (authors)

Non-physician practitioners in radiation oncology: advanced practice nurses and physician assistants

International Nuclear Information System (INIS)

Kelvin, Joanne Frankel; Moore-Higgs, Giselle J.; Maher, Karen E.; Dubey, Ajay K.; Austin-Seymour, Mary M.; Daly, Nancy Riese; Mendenhall, Nancy Price; Kuehn, Eric F.

1999-01-01

Purpose: With changes in reimbursement and a decrease in the number of residents, there is a need to explore new ways of achieving high quality patient care in radiation oncology. One mechanism is the implementation of non-physician practitioner roles, such as the advanced practice nurse (APN) and physician assistant (PA). This paper provides information for radiation oncologists and nurses making decisions about: (1) whether or not APNs or PAs are appropriate for their practice, (2) which type of provider would be most effective, and (3) how best to implement this role. Methods: Review of the literature and personal perspective. Conclusions: Specific issues addressed regarding APN and PA roles in radiation oncology include: definition of roles, regulation, prescriptive authority, reimbursement, considerations in implementation of the role, educational needs, and impact on resident training. A point of emphasis is that the non-physician practitioner is not a replacement or substitute for either a resident or a radiation oncologist. Instead, this role is a complementary one. The non-physician practitioner can assist in the diagnostic work-up of patients, manage symptoms, provide education to patients and families, and assist them in coping. This support facilitates the physician's ability to focus on the technical aspects of prescribing radiotherapy

Nurse Knowledge, Work Environment, and Turnover in Highly Specialized Pediatric End-of-Life Care.

Science.gov (United States)

Lindley, Lisa C; Cozad, Melanie J

2017-07-01

To examine the relationship between nurse knowledge, work environment, and registered nurse (RN) turnover in perinatal hospice and palliative care organizations. Using nurse intellectual capital theory, a multivariate analysis was conducted with 2007 National Home and Hospice Care Survey data. Perinatal hospice and palliative care organizations experienced a 5% turnover rate. The professional experience of advanced practice nurses (APNs) was significantly related to turnover among RNs (β = -.032, P < .05). Compared to organizations with no APNs professional experience, clinical nurse specialists and nurse practitioners significantly reduced RN turnover by 3 percentage points. No other nurse knowledge or work environment variables were associated with RN turnover. Several of the control variables were also associated with RN turnover in the study; Organizations serving micropolitan (β = -.041, P < .05) and rural areas (β = -.037, P < .05) had lower RN turnover compared to urban areas. Organizations with a technology climate where nurses used electronic medical records had a higher turnover rate than those without (β = .036, P < .05). The findings revealed that advanced professional experience in the form of APNs was associated with reductions in RN turnover. This suggests that having a clinical nurse specialist or nurse practitioner on staff may provide knowledge and experience to other RNs, creating stability within the organization.

Strategi Pengelolaan Usaha Jasa Rumah Pemotongan Hewan Ruminansia Secara Berkelanjutan (MANAGEMENT STRATEGY FOR SUSTAINABLE RUMINANT-CATTLE SLAUGHTERHOUSE (RC-S SERVICES

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Maya Dewi Dyah Maharani

2017-04-01

Full Text Available Uncontrolled cattle slaughtering may result in reduce water quantity and quality, number of cattle, and product of animal origin that does not fit the criteria of safety-healthy-whole-halal. The research objective was to analyze and measure important variables which might be required in developing a modelas well as to formulate strategic plans for managing sustainable abattoir services. Analysis methods used in this study were: Multidimensional Scaling (MDS or rap-slaughterhouse, Monte Carlo Analysis, and Analytical Hierarchy Process (AHP. Results of the analysis showed that the important variables were, i.e.: water availability and animal health status (ecological dimension; willingness to conduct hygienic and sanitation procedures at business scale level, service business orientation, availability of animal and slaughtering schedule management (economical dimension; workers safety and security (sociological dimension, noncompliance of the use of infrastructure by managers, workers and service users; lack off ulfillment of the requirements of the building frame (dimension regulations; and processing technology (technological dimension. The priority strategic analysis concluded that supply services of product of animal origin is eligible to be considered as components required in the food security program through the development and renovation program of effective slaughter houses. ABSTRAK Pemotongan hewan yang tidak terkendali mengakibatkan penurunan ketersediaan jumlah dan mutu air, hewan, dan pangan asal ternak yang tidak sesuai kriteria aman-sehat-utuh-halal (ASUH. Tujuan penelitian adalah menganalisis dan mengukur peubah-peubah penting yang diperlukan untuk menyusun model dan merancang rencana strategik pengelolaan usaha jasa rumah pemotongan hewan ruminansia secara berkelanjutan. Metode analisis yang digunakan adalah Multi Dimensional Scaling (MDS atau rap-slaughterhouse, Monte Carlo, dan Analytical Hierarchy Process. Hasil analisis

Acute Pyelonephritis with Perinephric Stranding on CT

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Ronald Goubert

2018-01-01

Full Text Available History of present illness: A 54-year old female presented to the emergency department with complaints of fevers, dysuria, urinary frequency, and diffuse abdominal pain. Her temperature was 103°F, but the remainder of her vital signs were normal. Upon physical examination, the patient had tenderness to palpation in the left upper and left lower abdomen and left costovertebral angle tenderness. Due to the location of pain (diverticulitis is in the differential for left-sided abdominal pain in this age group and patient’s reported history of nephrolithiasis, a computed tomography (CT scan of the abdomen and pelvis with intravenous (IV contrast was ordered because the physician felt this could best work up both of these possible conditions. Significant findings: A CT abdomen and pelvis with IV contrast showed neither nephrolithiasis nor diverticulitis, and instead showed heterogeneous enhancement of the left kidney with mild edematous enlargement and striated left nephrogram. Significant perinephric stranding (red arrows was also noted and was consistent with severe acute pyelonephritis. Discussion: Acute pyelonephritis (APN is a bacterial infection of the renal parenchyma which can present with a spectrum of symptoms including flank pain, high-grade fever, vomiting, and urinary tract symptoms.1,2 The diagnosis of APN can be made based on these clinical features with associated laboratory findings of bacteriuria, pyuria, positive urine cultures, and leukocytosis.1,2,7 Early diagnosis and treatment of APN is essential to prevent complications such as renal abscess or infarct, which could lead to renal failure, sepsis, and shock.3 CT has a sensitivity and specificity of 86.8% and 87.5%, respectively, for diagnosing APN. Common findings include striated nephrograms or perinephric fat stranding.2 However, imaging is not required for diagnosis and is typically reserved for patients who are immunocompromised, have severe symptoms, or show no clinical

Science.gov (United States)

Morisset, C.; Delgado-Inglada, G.; Torres-Peimbert, S.

2014-04-01

Most - if not all - planetary nebulae exhibit a complex structure, far from the spherical shape. The reasons for this dramatic change in symmetry, that occurs in early stage of the development of the nebula, remain controversial. The same physics operates in a variety of stars, from young (winds from young stars and/or high mass stars) to old (novae, symbiotic stars). The aim of the APN series of conferences has been to offer the opportunity to anyone involved in the study of asymmetric planetary nebulae (and related objects) to discuss the latest results obtained in this field. The APN VI conference was organized by the Instituto de Astronomia (UNAM) and took place on Riviera Maya, Quintana Roo, México, 4-8 Nov. 2013

Care Coordination for Children with Complex Special Health Care Needs: The Value of the Advanced Practice Nurse’s Enhanced Scope of Knowledge and Practice

Science.gov (United States)

Looman, Wendy S.; Presler, Elizabeth; Erickson, Mary M.; Garwick, Ann E.; Cady, Rhonda G.; Kelly, Anne M.; Finkelstein, Stanley M.

2012-01-01

Efficiency and effectiveness of care coordination depends on a match between the needs of the population and the skills, scope of practice, and intensity of services provided by the care coordinator. There is limited existing literature that addresses the relevance of the APN role as a fit for coordination of care for children with SHCN. The objective of this paper is to describe the value of the advanced practice nurse’s (APN’s) enhanced scope of knowledge and practice for relationship-based care coordination in healthcare homes that serve children with complex special health care needs (SHCN). The TeleFamilies project is provided as an example of the integration of an APN care coordinator in a healthcare home for children with SHCN. PMID:22560803

PENENTUAN KOEFISIEN DISPERSI ATMOSFERIK UNTUK ANALISIS KECELAKAAN REAKTOR PWR DI INDONESIA

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Pande Made Udiyani

2015-03-01

Full Text Available Atmosfer merupakan pathway penting pada perpindahan radionuklida yang lepas dari Pembangkit Listrik Tenaga Nuklir (PLTN ke lingkungan dan manusia. Penerimaan dosis pada lingkungan dan manusia dipengaruhi oleh sourceterm dan kondisi tapak PLTN. Untuk mengetahui penerimaan dosis lingkungan untuk PLTN di Indonesia, maka diperlukan nilai koefisien dispersi untuk tapak potensial yang dipilih. Model perhitungan dalam penelitian ini menggunakan model yang diterapkan pada paket program pada modul ATMOS dan CONCERN dari PC-Cosyma yaitu model perhitungan segmented plume model. Perhitungan dilakukan untuk PLTN tipe PWR kapasitas 1000 MWe berbahan bakar UO2, postulasi kejadian untuk kecelakaan DBA, kondisi tapak kasar, untuk 6 tapak contoh tapak Semenanjung Muria, Pesisir Banten, dan tapak yang didominasi oleh stabilitas cuaca C,D,E, dan F. Koefisien dispersi dihitung untuk 8 kelompok nuklida produk fisi yang lepas dari PLTN yaitu: kelompok gas mulia, lantanida, logam mulia, halogen, logam alkali, tellurium, cerium, dan kelompok stronsium & barium. Perhitungan input menggunakan paket program ORIGEN-2 dan Arc View untuk penyiapan input perhitungan. Hasil pemetaan untuk parameter dispersi maksimum rerata diperoleh pada jarak radius 800 m dari sumber lepasan untuk nuklida dari kelompok logam mulia, logam alkali dan kelompok nuklida cerium. Parameter dispersi untuk Tapak Muria maksimum 1,53E-04 s/m3, Tapak Serang adalah 1,40E-03 s/m3, tapak dengan stabilitas C: 1,72E-04 s/m3, stabilitas D: 1,40E-04 s/m3, Stabilitas E: 1,07E-04 s/m3, dan tapak dengan stabilitas F : 2,14E-05 s/m3. Kata kunci: koefisien dispersi, atmosferik, PWR, kecelakaan, Indonesia   The atmosphere is an important pathway in the migration of radionuclides transport from the Nuclear Power Plant (NPP to the environment and humans. The dose accepted in the environment and humans is influenced by the sourceterm and NPP siting condition. Distribution of radionuclides in the atmosphere is determined

PENGEMBANGAN WANA WISATA WATU SUMONG SEBAGAI KAWASAN EKOWISATA BERBASIS POHON AREN DAN PEMBERDAYAAN MASYARAKAT SECARA BERKELANJUTAN DI DESA PERON, LIMBANGAN, KENDAL

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Eram Tunggul Pawenang

2015-12-01

Full Text Available Tujuan dari kegiatan ini adalah untuk memperdalam pengertian, penghayatan, dan pengalaman mahasiswa tentang cara berfikir dan bekerja interdisipliner pada lintas sektoral yaitu bidang ilmu Kesehatan Masyarakat, Hukum dan Akuntansi Manajemen, kegunaan hasil pendidikan dan penelitian bagi pembangunan pada umumnya dan pembangunan daerah pedesaan khususnya Desa Peron dalam membudidayakan pohon aren dalam fungsi konservasi dan pemberdayaan hasil pengolahan aren sebagai fungsi produksi, bagi perguruan tinggi dapat mengembangkan IPTEKS yang lebih bermanfaat dalam pengelolaan dan penyelesaian berbagai masalah pembangunan. Masalah utama yang ada di Desa Peron adalah petani aren dalam pemasaran hasil masih tergantung dengan tengkulak, kurangnya diversifikasi dari aren menjadi produk-produk yang lain, pengemasan hasil diversifikasi olahan aren kurang menarik konsumen, pemanfaatan ijuk, akar dan daun dari pohon aren yang tidak maksimal, potensi Wisata Watu Sumong yang belum dieksplorasi secara optimal serta kurangnya pengetahuan masyarakat tentang pengolahan limbah aren. Hasil dari kegiatan KKN PPM meliputi Program pengemasan gula aren dilaksanakan dengan 3 variasi bentuk pengemasan yaitu Gula aren cetak, Gula Semut dan Sirup Aren dengan label “Arenku” dan sedang dalam proses permintaan no PIRT. Program pemasaran gula aren telah terlaksana yaitu dengan memasarkan produk gula aren berupa gula semut aren, gula cetak dan sirup aren di beberapa tempat yaitu di KPRI Handayani, UNSEC UNNES, dan Sekatul. Kegiatan Pengenalan Watu Sumong telah dilaksanakan dan mendapat apresiasi positif dari Bupati Kendal dan Dinas Kebudayaan dan Pariwisata Kendal dan akan dikembangkan menjadi Desa Wisata. Pengenalan juga dilaksanakan pada saat Peron Expo dengan menampilkan Video dan Pemasangan papan sejarah Watu Sumong dan Denah Lokasi Wisata di Desa Peron. Pengembangan desa Wisata akan dilanjutkan oleh Kelompok sadar wisata “Wikir Sari”. Program

PENGARUH KEPEMIMPINAN KEPALA SEKOLAH DAN KOMUNIKASI INTERNAL TERHADAP EFEKTIVITAS KERJA GURU SMK PGRI WONOASRI

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Ajeng Marga Kusuma

2017-04-01

Hasil penelitian menunjukkan 1 ada pengaruh secara parsial kepemimpinan Kepala Sekolah terhadap Efektivitas Kerja Guru SMK PGRI Wonoasri, 2 ada pengaruh secara parsial  komunikasi internal terhadap Efektivitas Kerja Guru SMK PGRI Wonoasri, 3 Ada Pengaruh secara simultan kepemimpinan Kepala Sekolah dan komunikasi internal terhadap efektivitas kerja guru SMK PGRI Wonoasri

Eye Movement Abnormalities in Multiple Sclerosis: Pathogenesis, Modeling, and Treatment

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Alessandro Serra

2018-02-01

Full Text Available Multiple sclerosis (MS commonly causes eye movement abnormalities that may have a significant impact on patients’ disability. Inflammatory demyelinating lesions, especially occurring in the posterior fossa, result in a wide range of disorders, spanning from acquired pendular nystagmus (APN to internuclear ophthalmoplegia (INO, among the most common. As the control of eye movements is well understood in terms of anatomical substrate and underlying physiological network, studying ocular motor abnormalities in MS provides a unique opportunity to gain insights into mechanisms of disease. Quantitative measurement and modeling of eye movement disorders, such as INO, may lead to a better understanding of common symptoms encountered in MS, such as Uhthoff’s phenomenon and fatigue. In turn, the pathophysiology of a range of eye movement abnormalities, such as APN, has been clarified based on correlation of experimental model with lesion localization by neuroimaging in MS. Eye movement disorders have the potential of being utilized as structural and functional biomarkers of early cognitive deficit, and possibly help in assessing disease status and progression, and to serve as platform and functional outcome to test novel therapeutic agents for MS. Knowledge of neuropharmacology applied to eye movement dysfunction has guided testing and use of a number of pharmacological agents to treat some eye movement disorders found in MS, such as APN and other forms of central nystagmus.

Identification of Bacillus thuringiensis Cry1AbMod binding-proteins from Spodoptera frugiperda.

Science.gov (United States)

Martínez de Castro, Diana L; García-Gómez, Blanca I; Gómez, Isabel; Bravo, Alejandra; Soberón, Mario

2017-12-01

Bacillus thuringiensis Cry toxins are currently used for pest control in transgenic crops but evolution of resistance by the insect pests threatens the use of this technology. The Cry1AbMod toxin was engineered to lack the alpha helix-1 of the parental Cry1Ab toxin and was shown to counter resistance to Cry1Ab and Cry1Ac toxins in different insect species including the fall armyworm Spodoptera frugiperda. In addition, Cry1AbMod showed enhanced toxicity to Cry1Ab-susceptible S. frugiperda populations. To gain insights into the mechanisms of this Cry1AbMod-enhanced toxicity, we isolated the Cry1AbMod toxin binding proteins from S. frugiperda brush border membrane vesicles (BBMV), which were identified by pull-down assay and liquid chromatography-tandem mass spectrometry (LC-MS/MS). The LC-MS/MS results indicated that Cry1AbMod toxin could bind to four classes of aminopeptidase (N1, N3, N4 y N5) and actin, with the highest amino acid sequence coverage acquired for APN 1 and APN4. In addition to these proteins, we found other proteins not previously described as Cry toxin binding proteins. This is the first report that suggests the interaction between Cry1AbMod and APN in S. frugiperda. Copyright © 2017 Elsevier Inc. All rights reserved.

Parenteral nutrition support for patients with pancreatic cancer. Results of a phase II study

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Riess Hanno

2010-03-01

Full Text Available Abstract Background Cachexia is a common problem in patients (pts suffering from upper gastrointestinal cancer. In addition, most of these patients suffer from malabsorption and stenosis of the gastrointestinal tract due to their illness. Various methods of supplementary nutrition (enteral, parenteral are practised. In patients with advanced pancreatic cancer (APC, phase angle, determined by bio-electrical impedance analysis (BIA, seems to be a survival predictor. The positive influence of BIA determinate predictors by additional nutrition is currently under discussion. Methods To examine the impact of additional parenteral nutrition (APN we assessed outpatients suffering from APC and progressive cachexia. The assessment based on the BIA method. Assessment parameters were phase angle, ECM/BCM index (ratio of extracellular mass to body cell mass, and BMI (body mass index. Patients suffering from progressive weight loss in spite of additional enteral nutritional support were eligible for the study. Results Median treatment duration in 32 pts was 18 [8-35] weeks. Response evaluation showed a benefit in 27 pts (84% in at least one parameter. 14 pts (43.7% improved or stabilised in all three parameters. The median ECM/BCM index was 1.7 [1.11-3.14] at start of APN and improved down to 1.5 [1.12-3.36] during therapy. The median BMI increased from 19.7 [14.4-25.9] to 20.5 [15.4-25.0]. The median phase angle improved by 10% from 3.6 [2.3-5.1] to 3.9 [2.2-5.1]. Conclusions We demonstrated the positive impact of APN on the assessed parameters, first of all the phase angle, and we observed at least a temporary benefit or stabilisation of the nutritional status in the majority of the investigated patients. Based on these findings we are currently investigating the impact of APN on survival in a larger patient cohort. Trial registration ClinicalTrials.gov Identifier: NCT00919659

Pengaruh Service Quality Terhadap Customer Satisfication English First Surabaya Town Square

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Prabowo, Randy Setio

2017-01-01

Tujuan dari penelitian ini adalah untuk menganalisa pengaruh service quality terhadap customer satisficationdan mengukur apakah memiliki pengaruh antara service quality terhadap customer satisfication baik secara stimultan maupun parsial.Hasil penelitian menunjukan bahwa service quality berpengaruh terhadap customer satisfication secara stilmultan dan secara parsial menunjukan bahwa variabel reliability dan responsiveness tidak memiliki pengaruh terhadap customer satisfication.

ANALISIS KUANTITATIF DAN KUALITATIF PENGENDALIAN BAHAYA TEMPAT KERJA DI PERUSAHAAN MACHINERY PT. X BEKASI

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Wahyu Setia Wisesa

2016-10-01

Full Text Available Perusahaan wajib menerapkan keselamatan dan kesehatan kerja, tetapi bagaimana manajemen dan karyawan dalam mempraktekan pengendalian bahaya di tempat kerja perlu dilakukan pengkajian. Tujuan penelitian ini adalah untuk mencari pengaruh pengendalian bahaya di tempat kerja secara kuantitatif pada perusahaan machinery PT. X Bekasi. Metode yang digunakan adalah kuesioner dan pengamatan lapangan dengan melibatkan 56 karyawan secara acak sebagai responden. Secara kuantitatif kuesioner diolah menggunakan uji statistik dengan SPSS versi 21 untuk mencari korelasi secara linier regresi sedangkan secara kualitatif pengamatan didokumentasikan berdasarkan kelengkapan penunjang pengendalian bahaya di tempat kerja. Hasil yang diperoleh menunjukkan adanya korelasi secara linier antara pengendalian bahaya di tempat kerja (Y, terhadap desain organisasi (X1, faktor pengendalian manusia (X2 dan pengendalian teknis (X3 dalam bentuk : Y= -5,355 + 1,037 . X1 + 0,996 . X2 + 1,017. X3 dengan koefisien determinasi = 0,994. Hasil pengamatan kualitatif di lapangan menunjukkan masih perlu peran aktif dari pihak manajemen perusahaan dan karyawan dalam menerapkan peraturan K3 serta mengendalikan bahaya di tempat kerja.

Pemetaan Distribusi Gas Polutan Menggunakan Quadcopter Berbasis Autonomous Waypoint Navigation

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Irfan Fachrudin Priyanta

2017-01-01

Full Text Available Pencemaran udara adalah suatu kondisi dimana kualitas udara menjadi rusak dan terkontaminasi oleh zat-zat, baik yang tidak berbahaya maupun berbahaya bagi makhlup hidup. Seiring dengan perkembangan dan pembangunan industri di Indonesia, akan berdampak pada meningkatnya tingkat pencemaran udara. Sistem monitoring emisi gas polutan industri secara umum dilakukan dengan cara manual menggunakan sensor gas pada titik-titik tertentu. Hal ini memakan waktu dan biaya cukup banyak. Quadcopter merupakan salah satu jenis Unmanned Aerial Vehicle (UAV yang mampu bergerak secara otomatis sesuai dengan sistem tracking waypoint. Sistem tracking waypoint merupakan sistem navigasi berdasarkan posisi Global Positioning System (GPS dan kompas, sehingga quadcopter dapat berjalan secara otomatis. Implementasi sensor gas semikonduktor dapat menunjang quadcopter untuk mengukur kadar gas di udara, sehingga dapat diaplikasikan sebagai alat monitoring secara otomatis. Data posisi GPS quadcopter dapat diakses secara langsung pada google maps di software mission planner. Kadar gas polutan disimpan pada web server raspberry pi 2 dan mampu diakses secara online. Hasil pemetaan kadar gas ditampilkan dalam 3D analyzer google earth.

A multidisciplinary prostate cancer clinic for newly diagnosed patients: developing the role of the advanced practice nurse.

Science.gov (United States)

Madsen, Lydia T; Craig, Catherine; Kuban, Deborah

2009-06-01

Newly diagnosed patients with prostate cancer have various treatment options, and a multidisciplinary prostate cancer clinic (MPCC) can present all options in a single setting. An MPCC was started in 2004 at the University of Texas M.D. Anderson Cancer Center, and 258 patients with prostate cancer were evaluated in its first year. The clinic expanded in 2006 and an oncology advanced practice nurse (APN) was recruited to address specific objectives. The APN role was used to implement a quality-of-life protocol, provide detailed patient education (including a treatment summary and care plan), and serve as a single point of contact as patients move toward a treatment decision. Formal evaluation of the MPCC showed that patients were satisfied with this approach to the complex decision-making process in prostate cancer.

PERFIL FARMACOTERAPÊUTICO DE PACIENTES PORTADORES DE DIABETES ASSISTIDOS PELO PROGRAMA SAÚDE DA FAMÍLIA DE MURIAÉ – MG

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Pedro Paulo Pedrosa NETTO, Marcelo Santos de OLIVEIRA, Ana Paula Rodrigues BRASIL de OLIVEIRA

2013-12-01

Full Text Available O objetivo deste trabalho foi avaliar o perfil farmacoterapêutico dos pacientes diabéticos assistidos por uma unidade do Programa Saúde da Família na cidade de Muriaé – MG. O trabalho foi delineado como um estudo quantitativo transversal realizado no período de fevereiro a junho de 2009 na unidade do Programa Saúde da Família (PSF do bairro São Gotardo no município de Muriaé-MG. A amostra foi constituída por 50 pacientes, que possuem diagnóstico de Diabetes mellitus, escolhidos aleatoriamente através dos prontuários médicos. As informações de cada participante foram obtidas por meio de entrevista, através de um questionário estruturado, realizada durante visita ao domicílio do paciente, acompanhado por um agente de saúde. Dos indivíduos avaliados, 64% são mulheres e 36% são homens, todos com diabetes tipo 2. A faixa etária predominante foi entre 50 a 69 anos. Os antidiabéticos eram usados por 96% dos avaliados e a maioria afirmou usar um ou mais medicamentos além dos antidiabéticos. Reações adversas e interações medicamentosas de algum tipo foram relatadas por 18% e 38%, respectivamente. Em virtude disso faz-se necessária a inclusão do farmacêutico, através da Atenção Farmacêutica, à equipe multiprofissional que assiste a esses pacientes diabéticos.

Nursing: What's a Nurse Practitioner?

Science.gov (United States)

... as advanced practice nurses, or APNs) have a master's degree in nursing (MS or MSN) and board certification ... NP training emphasizes disease prevention, reduction of health risks, and thorough patient education. Like doctors, NPs are ...

Alur Kerja Baru Simulasi Performa Bangunan Dalam Proses Desain Parametrik

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Firza Utama Sjarifudin

2010-12-01

Full Text Available Makalah ini menjelaskan hubungan alur kerja baru antara program pemodelan CAD 3D (Rhino/Grasshopper dan simulasi pencahayaan dengan (Radiance/Daysim. Alur kerja perancangan yang sangat efektif dalam Rhino disajikan secara langsung dengan mengekspor geometri, material properties, dan sensor grid ke dalam format Radiance/Daysim untuk menghitung serangkaian indikator performa termasuk peta radiasi matahari serta faktor pendistribusian pencahayaan dalam setahun. Hasil simulasi secara otomatis dikirim kembali ke dalam Rhino menggunakan pemetaan warna. Dengan menggunakan Grasshopper, parameter desain utama seperti ukuran jendela dan deskripsi material dapat diubah secara bertahap dan hasil simulasi dapat dikombinasikan menjadi sebuah simulasi performa bangunan dalam bentuk animasi transformasi parametrik. Desain alur kerja ini telah secara khusus dikembangkan bagi proses perancangan arsitektur dengan menyediakan semua feedback yang sangat berguna bagi perancang secara interaktif dari tahap rancangan skematis sampai tahap pengembangan perancangan. 

الطريقة التوليفية في تدريس مهارة القراءة للناطقين بغير العربية

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Rahmadon

2016-01-01

Full Text Available Qiraah atau membaca dalam pengajaran bahasa arab merupakan salah satu keterampilan bahasa, membaca secara umum bertujuan agar para siswa mampu mendapatkan informasi secara langsung dari teks dan naskah bacaan dalam bahasa arab. Sehingga seorang dikatakan mampu membaca ketika ia dapat memahami isi bacaan secara sempurna kemudian mampu ‘menerjemahkannya’ dalam pikirannya secara total dan dapat memberikan kesimpulan terhadapa bacaan tersebut. Tentunya kemahiran membaca membutuhkan usaha yang sungguh-sungguh dari diri pembaca itu sendiri. Bagi orang yang tidak berbicara dengan bahasa arab atau siswa non arab, membaca naskah arab memerlukan metode yang tepat untuk bisa sampai pada tujuan pemahaman. Metode pengajaran qiraah yang digunakan guru atau pengajar bagi siswa non Arab harus menjawab permasalahan kesulitan mereka dalam memahami bacaan. Terdapat banyak Metode dalam pengajaran Kemahiran Membaca diantaranya, Metode Tarkibi, Metode Tahlili dan Metode Jumlah, yang kesemuanya tentu saja mempunyai kelebihan dan kekurangan dalam terapannya.Dalam tulisan ini, penulis ingin membahas secara mendetil metode tersebut dengan menyarankan satu metode yang dianggap paling tepat untuk pengajaran qiraah bagi siswa non Arab yaitu yang disebut dengan metode Tulifiyah dimana metode ini sebenarnya adalah hasil penggabungan ketiga metode diatas dari sisi kelebihan dan meminimalisir kekurangan yang dimilikinya. Lebih lanjut akan dibahas tentang detil dari metode ini dari pengertian sampai bagaimana terapannya sehingga membantu guru atau pengajar dalam proses pembelajaran keterampilan membaca secara khusus dan proses pembelajaran bahasa Arab secara umum.

Resensi Buku: PENGANTAR UMUM HUKUM EKONOMI Pengarang: John W. Head Penerbit: ELIPS Project (1997

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Dwi Tatak Subagiyo

1998-04-01

Full Text Available Dalam masa krisis ekonoml ini masyarakat sedang mencari dan mengupayakan penyelesaian secepatnya. Penyelesaiannya ini memang banyak sekali aspek yang terlibat didalamnya, antara lain budaya, hukum, ekonomi dan sosial. Aspek hukum memang tidak terlepaskan dalam hal ini. Dengan terbitnya buku pengantar umum hukum ekonomi ini kiranya dapat memberikan sumbangan pemikiran untuk membantu sedikit penyelesaian masalah hukum ekonomi. Buku ini berisikan materi yang bermuatan hukum ekonomi secara makro, sehingga bagi pembacanya dalam menyimak harus berhati-hati. Karena di dalamnya membahas mulai dari organisasi perusahaan, hukum persaingan, pembiayaan bisnis/usaha, aturan akuntansi, kepailitan, hukum kontrak dan hukum dagang, penyelesaian sengketa dagang, hukum perbankan, asuransi, hukum perburuhan, hukum sumber daya alam dan lingkungan, tanggung jawab produk dan perlindungan konsumen, hukum perpajakan, transaksi bisnis internasional secara umum, jual beli barang internasional aspek-aspek transaksi, jual beli barang internasional aspek-aspek peraturan perundang-undangan, lisensi dan investasi internasional sampai dengan organisasi ekonomi internasional. Organisasi perusahaan disinggung masalah kepemilikan tunggal usaha, perusahaan dengan lialibiltas terbatas, badan usaha pemerintah, badan usaha multinasional. Organisasi perusahaan juga dibandingkan antara sistem common law dan civil law (hal. 2. Hukum persaingan yang dulunya mencerminkan ideologi atau filsafat suatu perekonomian, sekarang sudah dapat diterima di seluruh dunia setelah jatuhnya Uni Soviet (hal 9. Pembiayaan bisnis berisikan pembiayaan dalam modal penyertaan, pembiayaan jangka pendek dan pembiayaan dengan surat berharga. DidaIamnya diuraikan secara singkat sistem pembiayaan bisnis yang ada dalam kehidupan sehari-hari. Aturan akuntansi berisikan tentang sejarah aturan akuntansi perlunya keseragaman, persyaratan dispositif dan persyaratan pembeberan, standar akuntansi pokok, neraca dan laporan

Pengaruh Bauran Pemasaran terhadap Persepsi Konsumen dalam Penciptaan Ekuitas Merek: Studi Kasus Restoran Clemmons Bandung Indah Plaza

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Danil, Lilian

2016-01-01

Penulis mengajukan suatu kerangka kerja dimana persepsi konsumen atas bauran pemasaran dihubungkan dengan dimensi-dimensi ekuitas merek yaitu persepsi kualitas, loyalitas merek dan asosiasi merek yang dikombinasikan dengan kesadaran merek. Hasil penelitian menunjukkan bahwa persepsi konsumen atas bauran pemasaran dan dimensi ekuitas merek secara signifikan mempengaruhi ekuitas merek secara keseluruhan baik secara simultan maupun parsial, terhadap Brand Equity kecuali Store Image terhadap Bran...

Studi Perbandingan Metode Bongkar Muat untuk Pelayaran Rakyat: Studi Kasus Manual vs Mekanisasi

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Aulia Djeihan Setiajid

2013-03-01

Full Text Available Pelayaran Rakyat tidak semaju pelayaran konvensional. Salah satu penyebabnya adalah pola operasi bongkar muat yang kebanyakan dilakukan secara manual dengan tenaga manusia/buruh lepas.Penelitian ini bertujuan untuk mengetahui apakah dengan adanya mekanisasi peralatan bongkar muat dan penggunaan gudang bersama mampu meningkatkan kinerja bongkar muat serta menentukan metode bongkar muat seperti apa yang optimal dan menguntungkan untuk Pelra. Penelitian ini dilakukan dengan mengembangkan skenario dan membandingkan efisiensi setiap metode bongkar muat secara manual, mekanisasi, dan campuran pada kapal Pelra serta membandingkan efisiensi setelah menggunakan gudang bersama.Dari hasil analisis diperoleh hasil penambahan biaya bongkar muat sebesar 80% dari biaya awal sehingga penggunaan metode bongkar muat secara manual akan lebih menguntungkan dan optimal. Namun dari segi waktu, mekanisasi bongkar muat dapat mempercepat waktu sebanyak 31% dari awal bongkar muat secara manual. Dari segi kinerja bongkar muat terhadap kinerja total kapal Pelra dengan metode manual lebih besar yaitu sebesar 14% dibandingkan secara mekanisasi dan campuran yang hanya 10% dan 9%. Hal ini menunjukkan kinerja bongkar muat rata-rata untuk metode bongkar muat baik secara manual, mekanisasi, dan campuran tidak berpengaruh besar terhadap produktivitas kapal karena ketidakpastian adanya muatan sehingga frekuensi round trip kapal Pelra sama saja tiap tahunnya.

PERAMALAN PENENTUAN JUMLAH PERMINTAAN KONSUMEN BERBASIS TEKNOLOGI INFORMASI TERHADAP PRODUK BORDIR PADA KOTA TASIKMALAYA

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Lies Sunarmintyastuti

2016-12-01

Full Text Available Peramalan penentuan jumlah permintaan konsumen berbasis teknologi informasi terhadap produk bordir di Kota Tasikmalaya, mempunyai tujuan khusus untuk menentukan jumlah kebutuhan permintaan konsumen secara periodik, berkala dan pola kebutuhan permintaan konsumen dimasa yang akan datang secara trend, musiman. Penelitian ini berawal dari konsep pemikiran bagaimana supaya produsen bordir di Kota Tasikmalaya mendapatkan pendapatan yang optimal dan efisien dalam biaya produksi bordir mereka. Pendekatan peramalan dalam penelitian ini menggunakan metode Time Series dengan menggunakan Single Exponential Smoothing Modeluntuk mendapatkan nilai peramalan secara periodik, Double Exponential Smoothing Modeluntuk mendapatkan nilai peramalan secara trend dan Triple Exponential SmoothingModeldengan Multiplicative Seasonal Modeluntuk mendapatkan nilai peramalan secara musiman, serta pengujian peramalan menggunakan MAD, MAPE dan MSE untuk mencari error terkecil. Pada tahap berikutnya dibangun sebuah sistem peramalan penentuan permintaan konsumen dengan menggunakan metode pengembangan sistem waterfall dan pembuatansoftware yang dirancang menggunakan bahasa pemrograman Java dengan editor NetBeans dan database MySQL.

The Change of Left Ventricular Function in Rats with Subclinical Hypothyroid and the Effects of Thyroxine Replacement.

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Chen, Xuedi; Gao, Cuixia; Gong, Ningning; Wang, Yu; Tian, Limin

2018-01-01

The main purpose of this study was to explore the relationships between serca2a, Ryr2, adipokines, and the left ventricular function in the subclinical hypothyroidism with different TSH levels and to determine the impact of L-T4 treatment on these indexes. Sixty-five male Wistar rats were randomly divided into five groups: control group; sHT A, B, and C group; and sHT + T4 group. The sHT rats were induced by methimazole (MMI), and the sHT + T4 rats were administered with L-T4 treatment after 8 weeks of MMI administration. Serum TT4, TSH, APN, chemerin, and TNF- α were detected by radioimmunoassay kits and ELISA kits; left ventricular function was measured by PowerLab system via subclavian artery catheter. The expression of Serca2a, Ryr2, APN, chemerin, and TNF- α were detected by RT-PCR, Western blot, and immunohistochemistry. The sHT groups had significantly higher TSH, chemerin, and TNF- α and lower Serca2a, Ryr2, and APN. The left ventricular pressure and heart rate in sHT groups were significantly lower in control and sHT + T4 group. Histopathological examination revealed the pathological changes in the sHT rats' heart. L-T4 administration reduced TSH level and improved left ventricular function. TSH can impair left ventricular function by regulating several factors, and L-T4 treatment ameliorates it in sHT rats.

Removal of Malachite Green from water using hydrothermally carbonized pine needles

KAUST Repository

Hammud, Hassan Hasan; Shmait, Abeer; Hourani, Nadim

2015-01-01

Hydrothermal carbonization of pine needles (HTC-PN) and their oxidized-activated form HTC-APN are prepared and applied for the adsorption of Malachite Green (MG) in aqueous solution. The HTC materials were characterized by thermal and TEM analysis

MONITORING KEMAJUAN PENGERJAAN PROYEK BELT CONVEYOR PLANT 14 HAMBALANG BERBASIS WEB

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Juliana Juliana

2018-04-01

Full Text Available Kriteria yang harus dipenuhi produk yang dihasilkan dari proyek meliputi kriteria atau batasan waktu, batasan ruang lingkup, batasan biaya dan batasan kualitas. Untuk itu, maka perlu dilakukan monitoring untuk mengetahui kemajuan proyek sehingga keempat kriteria tersebut terpenuhi. Progress atau kemajuan proyek menjadi indikator dalam monitoring untuk menilai perkembangan pelaksanaan pekerjaan dibandingkan dengan rencana. Perkembangan pelaksanaan proyek harus dilaporkan secara periodik. Pada pelaksanaan proyek pembangunan belt conveyor plant 14 Hambalang, PT Unixindo Ekatama Sentana dalam melakukan monitoring perkembangan proyek belum ada sistem pelaporan yang terintegrasi dan pengolahan data masih dilakukan secara manual dengan menggunakan aplikasi Ms.Excel. Dalam penelitian ini dibangun sistem informasi monitoring pelaporan proyek untuk memudahkan monitoring kemajuan proyek. Aplikasi untuk monitoring kemajuan proyek yang dibangun dengan berbasis web menggunakan PHP dan MySQL. Tujuan dari penelitian yang dilakukan yaitu untuk menghasilkan sistem informasi untuk melakukan monitoring kemajuan proyek berbasis web dan tersedia sistem pelaporan kemajuan proyek yang terintegrasi sehingga memudahkanperusahaan dalam memonitoring proyek secara online. Manfaat yang diharapkan dari adanya sistem monitoring kemajuan proyek secara online adalah memudahkan proses monitoring kemajuan proyek yang dapat dilakukan secara online. Dari penelitian dihasilkan sistem informasi monitoring yang dibuat memudahkan pelaporan proyek di lapangan yang dilakukan secara online sehingga perusahaan dapat memonitor kemajuan proyek secara kontinyu dan dapat digunakan untuk menilai perkembangan pekerjaan proyek yang dibandingkan dengan perencanaan proyek sehingga dapat mengambil keputusan untuk melakukan perbaikan. Kata kunci: kemajuan proyek, pelaporan proyek, monitoring proyek berbasis web.

Aplikasi Short Message Service (SMS dan Email Sebagai Media Komunikasi Data dalam Sistem Pemantauan Suhu

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Andi Adriansyah

2011-06-01

Full Text Available      Sistem pemantauan suhu secara langsung dengan mencatat setiap perubahan suhu secara manual, terlebih pada kondisi suhu yang ekstrim, memiliki resiko yang dapat berakibat fatal. Oleh karena itu dibutuhkan sebuah sistem yang dapat melakukannya secara otomatis. Penelitian ini bertujuan merancang sebuah sistem mandiri yang dapat melakukan pemantauan dan pencatatan perubahan suhu secara near real time (NRT dan mengirimkan laporan secara otomatis melalui email dan SMS. Sistem terdiri dari Sensor suhu LM35 yang berfungsi merubah besaran fisis suhu ke besaran listrik tegangan, Microcontroller Atmega8535 yang memegang peranan untuk mengkonversi tegangan keluaran LM35 kedalam bentuk digital, serta mengirimkan data hasil konversi melalui komunikasi serial ke computer. Program Java yang dijalankan di computer berfungsi memproses data yang dikirim mikrokontroler ATmega8535, menyimpannya ke basis data MySQL, menampilkannya dalam bentuk tabel dan grafik, dan mengirimkan laporan melalui email dan SMS bila data suhu yang diterima melebihi ambang batas yang telah ditentukan.

TENAGA SURYA DAN ARSITEKTUR: SUATU ANALISIS LINGKUNGAN DAN PERANCANGAN

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Tri Harso Karyono

2003-01-01

Full Text Available This paper discusses the potential use of solar energy in building as an alternative solution of energy resources to reduce the negative impact in burning fossil fuels to the environment. It higlights the positive aspects in environment by generating solar energy and also discusses the aesthetical values in employing solar panels on buildings. Abstract in Bahasa Indonesia : Isue mengenai pemanasan bumi yang diakibatkan oleh produksi gas karbon dioksida sebagai akibat pembakaran bahan bakar minyak (minyak bumi, batu bara, gas alam memaksa ilmuwan, pakar energi, akhli lingkungan, serta pihak-pihak lain yang terkait untuk ikut memikirkan penggunaan energi alternatif yang aman. Tenaga nuklir yang tidak menghasilkan gas buang semacam karbon dioksida, ternyata bukan merupakan solusi energi alternatif yang baik karena meninggalkan sampah radioaktif yang belum ada solusi pembuangan yang diangap aman untuk masa yang akan datang. Tenaga surya, yang umumnya sudah digunakan secara tradisional sejak ratusan abad yang silam, perlu mendapat perhatian. Pemanfaatan tenaga surya baik secara pasif maupun aktif bagi bangunan perlu mendapat perhatian dari para arsitek. Pemanfaatan tenaga surya secara aktif, dimana tenaga surya dikonversikan terlebih dahulu menjadi tenaga listrik dengan solar sel, seyogyanya tidak berdiri sendiri, perlu diintegrasikan dengan aplikasi perancangan secara pasif. Perancangan secara aktif bertujuan untuk mengurangi beban listrik yang berasal dari minyak bumi - secara langsung mengurangi jumlah gas karbon dioksida yang dibuang ke udara, sedangkan perancangan pasif bertujuan untuk mengurangi beban penggunaan energi listrik - yang berasal dari sumber listrik apapun - di dalam bangunan. Makalah ini membahas isue yang diutarakan diatas, dimana pada akhirnya memberikan contoh dari suatu karya arsitektur yang dianggap berhasil dalam mengaplikasikan strategi perancangan secara aktif (menggunakan solar sel serta tidak meninggalkan sterategi

The relationship of the levels of serum white blood cell classification, adiponectin and C-reactive protein with neurological function score and clinical prognosis in patients with cerebral infarction%白细胞分类、脂联素、C-反应蛋白水平与脑梗死患者神经功能评分及临床预后的关系

Institute of Scientific and Technical Information of China (English)

曹春萍

2017-01-01

目的 探讨血清中白细胞分类、脂联素(APN)、C-反应蛋白(CRP)水平与脑梗死患者神经功能评分及临床预后的关系.方法 收集本院2015年9月-2016年9月收治的急性脑梗死患者128例,根据患者临床预后分为预后不良组(27例)和预后良好组(101例),采用ELISA法检测患者血清中白细胞分类、APN、CRP水平,采用Logisitic回归分析探讨急性脑梗死患者临床预后的危险因素.结果 预后不良组患者血清CRP、CRP/APN水平高于预后良好组,而预后不良组APN水平低于预后良好组;预后不良组患者白细胞计数、中性粒细胞比例、单核细胞比例、中性粒细胞/淋巴细胞比值均高于预后良好组患者;预后不良组患者NIHSS评分高于预后良好组患者,上述差异均有统计学意义(P＜0.05).CRP/APN、中性粒细胞/淋巴细胞比值、NIHSS评分是脑梗死患者死亡的独立危险因素(P＜0.05).结论 急性脑梗死患者临床预后不一,血清中白细胞分类、CRP/APN水平与患者炎症反应密切相关.%Objective To investigate relationship of the levels of serum white blood cell classification,adiponectin and C-reactive protein(CRP) with neurological function score and clinical prognosis in patients with cerebral infarction.Methods 128 cases of acute cerebral infarction patients were selected in our hospital from September 2015 to September 2016.According to the clinical prognosis,patients were divided into the ideal prognosis group(101 cases) and the poor prognosis.Enzyme-linked immunosorbent assay(ELISA) was used to detect the white blood cell classification,APN and CRP levels.Logisitic regression was used to explore the risk factors of clinical prognosis in patients with acute cerebral infarction.Results Serum CRP and CRP/APN levels of poor prognosis group were higher than that of the good prognosis group,while APN level was lower than that of the good prognosis group;the lymphocyte white blood cell count

PENGARUH GOOD CORPORATE GOVERNANCE, DAN PENGUNGKAPAN CORPORATE SOCIAL RESPONSIBILITY TERHADAP NILAI PERUSAHAN (PADA PERUSAHAAN PROPERTY AND REAL ESTATE YANG TERDAFTAR DI BEI

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Febi Triyono

2015-03-01

Full Text Available Tujuan dari penelitian ini adalah untuk menguji pengaruh mekanisme corporate governance, yang terdiri dari kepemilikan manajerial, dewan komisaris independen, ukuran komite audit, dan kualitas audit serta pernyataan tanggung jawab sosial perusahaan terhadap nilai perusahaan. Pengambilan sampel penelitian ini adalah purposive random sampling dengan properti dan perusahaan real estate yang terdaftar di Bursa saham Indonesia pada laporan tahunan 2009-2012. Dari hasil F-test menunjukkan bahwa mekanisme corporate governance dan laporan CSR secara bersamaan mempengaruhii secara signifikan terhadap nilai perusahaan. menggunakan t-test menunjukkan bahwa kepemilikan manajerial dan kualitas audit dipengaruhi secara signifikan terhadap nilai perusahaan. Dan komisaris independen papan, komite audit, dan pernyataan CSR tidak terpengaruh secara signifikan terhadap nilai perusahaan.

ANALISIS POLA INTERAKSI SERANGGA-GLMA PADA EKOSISTEM SAWAH SURJAN DAN LEMBARAN YANG DIKELOLA SECARA ORGANIK DAN KONVENSIONAL (Analysis of Insect-Weed Interaction Pattern in Surjan and Lembaran Rice Farm Ecosystems under Organic and Conventional

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Tien Aminatun

2012-11-01

Full Text Available ABSTRAK Penelitian ini bertujuan untuk menganalisis struktur food web dalam pola interaksi serangga-gulma pada ekosistem sawah surjan dan lembaran yang dikelola secara organik dan konvensional.        Penelitian dilakukan pada enam petak sawah surjan dan enam petak sawah lembaran di daerah Kulon Progo dalam dua musim tanam pada bulan Desember 2009 sampai Juli 2010.  Baik sawah surjan maupun sawah lembaran, masing-masing dibedakan dalam dua pengelolaan, yaitu pengelolaan organik dan konvensional, dengan ulangan masing-masing tiga petak.  Lima plot ukuran 1x1 m ditempatkan pada masing-masing petak yang tidak diubah posisinya sampai berakhir satu musim tanam. Inti dari penelitian lapangan ini adalah menghitung jenis dan kelimpahan gulma setiap tiga minggu sekali untuk setiap petak, demikian juga untuk jenis dan kelimpahan dari serangga herbivora untuk setiap jenis tanaman/gulma pada setiap plot. Analisis data dilakukan dengan program Bipartite in R statistics 2.12.0, dan dilakukan uji pengaruh tipe sawah dan cara pengelolaan lahan terhadap struktur dan network level (jumlah jenis trofik atas, jumlah jenis trofik bawah, keterhubungan, diversitas Shannon, dan kemerataan interaksi dengan menggunakan General Linear Model (GLM dalam program SPSS 17.0. Hasil penelitian sawah surjan yang dikelola secara organik mempunyai pola interaksi serangga-gulma yang lebih kompleks dengan lebih banyak link interaksi, jumlah jenis trofik atas dan bawah, indeks diversitas Shannon, dan kemerataan interaksi yang lebih tinggi, serta keterhubungan (connectance yang lebih rendah.  ABSRACT The aims of this research was to analyse food web structure of insect-weed interaction in surjan and lembaran rice field ecosystems under organic and conventional managements. We observed six rice fields of local farms called “surjan” rice fields, and six rice fields of “lembaran” farms in Kulon Progo District, central Java, in two planting seasons in December 2009 until

TAREKAT KADIRAN PADA MASYARAKAT KADUARA TIMUR PRAGAAN SUMENEP

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Saiful Hadi

2013-01-01

Full Text Available Tarekat Kadiran adalah sebuah ritual keagamaan yang sudah mentradisi pada masyarakat Kaduara Timur Paragaan Sumenep. Walaupun masyarakat Kaduara tidak memiliki catatan secara pasti tentang sejarah Kadiran, tetapi mereka sudah menjadikannya sebagai suatu tradisi yang terus dipertahankan secara turun-temurun, berlangsung sekian lama dan eksis sampai saat ini. Penelitian ini didekati secara kualitatif fenomenologis untuk mengungkap masyarakat Kaduara Timur setia menjalankan tradisi Kadiran. Kedua, bentuk kesetiaan masyarakat terhadap tradisi Kadiran, sampai saat ini tetap eksis secara turun temurun dan mereka berupaya mewariskannya kepada anak cucunya. Keempat, tradisi Kadiran ini sampai sekarang tidak ada perubahan secara signifikan, masyarakat Kaduara Timur berupaya menjaga keaslian tradisi ini. Hasil penelitian yang diperoleh adalah Tradisi Kadiran ini memiliki keunikan-keunikan tersendiri yang menjadi ciri khas serta memiliki makna simbolik mendalam bagi masyarakat sebagai sebuah internalisasi keber-Islam-an mereka yang termanifestasikan dalam pola hidupnya. Aktualisasi ritual keagamaan dalam bentuk selamatan atau rokatan, berdzikir dengan amalan Syekh Abdul Qodir al Jailani yang diawali dengan prosesi memasak makanan atau hidangan yang dilakukan orang laki-laki tanpa batal wudlu dan tidak boleh bercakap-cakap. Secara simbolik memasak tanpa batal dari hadast adalah manifestasi keberislaman yang bertujuan menghidangkan makanan kepada orang yang ikut berdzikir agar do’a-do’a yang disampaikan diterima oleh Allah Swt.

A cooperação como elemento aglutinador dos Arranjos Produtivos Locais

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Cecilia Alves da Silva Antero

2017-01-01

Full Text Available This study analyzes the criteria and implications of cooperation in LPAs, by identifying situations that affect the implementation of joint actions. They were carried out bibliographic, descriptive and documental research, with the empirical unit of analysis the clothing LPA Muriaé-MG in southeastern Brazil. Therefore, primary qualitative data were used (obtained from semistructured interviews conducted in July 2014 and secondary (Caged and Diagnosis of Garment Industry Muriaé and Region, 2010, analyzed by Nvivo® software support, basing in the content analysis technique. Considering the type of joint action, the purpose and resource sharing, the results showed that cooperation occurs: between companies, through actions relating to machinery sharing; between entities, per various forms of joint action, as hand work training, technology consulting, LPA dissemination and meetings; and between companies and organizations due to the joint action directed to the use of labor, in which the actors involved share human and information resources. With regard to the analysis criteria of cooperation, identify situations that generate positive implications (scope, objective and shared resource and negative (diversity, frequency and benefits for the development of said LPA. It is considered that the model for analysis of the proposed cooperation meets the expectations regarding the assemblage of elements necessary to characterize it, systematize it and understand it in the context of LPA. The analysis shows that cooperation is incipient, which has negative implications for the development of said LPA. It is suggested that alternatives be identified to promote cooperation between the actors and it is necessary to create favorable conditions for cooperation and awareness of the benefits from this practice.

Model Polikultur Udang Windu (Penaeus monodon Fab, Ikan Bandeng (Chanos-chanos Forskal dan Rumput Laut (Gracillaria Sp. Secara Tradisional

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Murachman - -

2012-05-01

,157 mgl-1, H2S 0,025 mgl-1, NO2 0,109 mgl-1, PO4-3 0,461 mgl-1, pH 8,05, TOM 38.635 mgl-1, TSS 176,418 mgl-1, alkalinitas 4,665 mgl-1, suhu 32.96 °C, kadar garam 32,5, BOD 2,88 mgl-1 dan kandungan Pb 0,245 mgl-1. Secara kualitatif dan kuantitatif tingkat produksi udang windu adalah (201.11 kgha-1m-1 dan ikan bandeng (1180,56 kgha-1m-1 pada sistem polikultur tiga komoditas lebih tinggi daripada tingkat produksi di sistem polikultur dua komoditas. Secara kuantitatif diketahui bahwa untuk budidaya udang windu kelimpahan plankton adalah 11,466 ekor tiap liter, pertumbuhan absolut 23,93 g, lemak 0,604, tingkat kelangsungan hidup 53% dan rata-rata ukuran tubuh adalah  34 ekor tiap kg. Parameter untuk budidaya ikan bandeng adalah  kelimpahan plankton adalah 69,845 ekor tiap liter, pertumbuhan absolut 354,99 g, lemak 0,604, tingkat kelangsungan hidup 95% dan rata-rata ukuran tubuh adalah 4,25 ekor tiap kg. Keuntungan finansial pada polikultur tiga komoditas adalah Rp. 20.717.628 dan Rp. 11.924.115 pada polikultur dua komoditas untuk tiap hektar tambak pada satu musim tanam.   Katakunci: polikultur, ikan bandeng, komoditas, udang windu     Abstract Polyculture is an alternative to solving water quality problems leading to decrease of fish production in the ponds. The present research is aimed at establishing the management of polyculture of black tiger prawn, milkfish, and seaweed. This study employs method of case study in Dusun Tanjung Sari, Desa Kupang, sub-district of Jabon, Regency of Sidoarjo. Samples were collected from 18 polyculturers of three commodities (black tiger prawn, milkfish, and seaweed and 20 polyculturers of two commodities (black tiger prawn and milkfish by means of proportional sampling. Variables to be investigated were type of commodity, treatment in the polyculture processes, stocking density, water quality, mangrove forest, social and economic institutions, investment and operational funds, production, quality and fertility of water, and financial

Pressure ulcer multidisciplinary teams via telemedicine: a pragmatic cluster randomized stepped wedge trial in long term care.

Science.gov (United States)

Stern, Anita; Mitsakakis, Nicholas; Paulden, Mike; Alibhai, Shabbir; Wong, Josephine; Tomlinson, George; Brooker, Ann-Sylvia; Krahn, Murray; Zwarenstein, Merrick

2014-02-24

The study was conducted to determine the clinical and cost effectiveness of enhanced multi-disciplinary teams (EMDTs) vs. 'usual care' for the treatment of pressure ulcers in long term care (LTC) facilities in Ontario, Canada We conducted a multi-method study: a pragmatic cluster randomized stepped-wedge trial, ethnographic observation and in-depth interviews, and an economic evaluation. Long term care facilities (clusters) were randomly allocated to start dates of the intervention. An advance practice nurse (APN) with expertise in skin and wound care visited intervention facilities to educate staff on pressure ulcer prevention and treatment, supported by an off-site hospital based expert multi-disciplinary wound care team via email, telephone, or video link as needed. The primary outcome was rate of reduction in pressure ulcer surface area (cm2/day) measured on before and after standard photographs by an assessor blinded to facility allocation. Secondary outcomes were time to healing, probability of healing, pressure ulcer incidence, pressure ulcer prevalence, wound pain, hospitalization, emergency department visits, utility, and cost. 12 of 15 eligible LTC facilities were randomly selected to participate and randomized to start date of the intervention following the stepped wedge design. 137 residents with a total of 259 pressure ulcers (stage 2 or greater) were recruited over the 17 month study period. No statistically significant differences were found between control and intervention periods on any of the primary or secondary outcomes. The economic evaluation demonstrated a mean reduction in direct care costs of $650 per resident compared to 'usual care'. The qualitative study suggested that onsite support by APN wound specialists was welcomed, and is responsible for reduced costs through discontinuation of expensive non evidence based treatments. Insufficient allocation of nursing home staff time to wound care may explain the lack of impact on healing

The role and functions of Clinical Nurse Consultants, an Australian advanced practice role: a descriptive exploratory cohort study.

Science.gov (United States)

Baldwin, Richard; Duffield, Christine Margaret; Fry, Margaret; Roche, Michael; Stasa, Helen; Solman, Annette

2013-03-01

The NSW Health Policy Directive (NSW Department of Health, 2000) lists clinical service and consultancy; clinical leadership; research; education; clinical services planning and management as the five domains of practice for nurses appointed as Clinical Nurse Consultants (CNCs), an Australian advanced practice nurse (APN) role. However, there is no clear definition of what is meant by advanced practice in the Australian nursing context. Nowhere is this more evident than in differentiating between the roles of Clinical Nurse Consultants (CNCs) and Nurse Practitioners (NP) in NSW. To date, limited empirical research has been done to characterise or delineate CNC role activity and responsibility. To investigate (i) the nature of CNC roles, activities and responsibilities, (ii) differentiate between CNCs by their work patterns and activities, and (iii) empirically conceptualize and differentiate ways CNCs practice in terms of an APN typology. The study sample was 56 CNCs at one tertiary level public hospital in Australia. A descriptive exploratory cohort study was conducted to explore CNC role characteristics and patterns of activity. Data were triangulated using an online survey, a follow-up survey, and semi-structured interviews. The data were analysed using descriptive statistics to examine differences between CNC work patterns and role activities. The survey data and the individual reports were thematically analysed to investigate for difference across the population of CNCs. Interpretation of survey and interview data led to an analyst-developed CNC typology of four CNC categories based on the work patterns and activities of Sole Practitioner, Clinic Coordinator, Clinical Team Coordinator and Clinical Leader. The typology was based on the themes interprofessional, role focus, clinical focus and setting as these themes distinguished and differentiated CNC roles. The study provides evidence of great diversity and prioritization within CNC roles. The CNC typology

Pengaruh Relationship Marketing terhadap Loyalitas Nasabah pada PT. Bank Pembiayaan Rakyat Syariah (BPRS Berkah Dana Fadhlillah Di Kabupaten Kampar Provinsi Riau

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yusriadi yusriadi

2017-09-01

Full Text Available Abstrak: Penelitian ini untuk mengetahui pengaruh relationship marketing yang variabelnya meliputi financial benefit, social benefit dan structural benefit terhadap loyalitas nasabah pada PT. BPRS Berkah Dana Fadhlillah Kabupaten Kampar baik secara parsial maupun secara simultan. Penelitian ini juga bertujuan untuk mengetahui dan menjelaskan berapa persen ketiga variabel tersebut menjelaskan pengaruhnya terhadap loyalitas nasabah. Dengan menggunakan alat analisa regresi berganda, di peroleh hasil variabel financial benefit berpengaruh secara positif terhadap loyalitas nasabah dengan nilai t hitung sebesar 8,763 > t Tabel 1,9796 dan nilai signifikansi sebesar 0,000 < 0,05. Variabel social benefit hasilnya berpengaruh secara negatif terhadap loyalitas nasabah dengan nilai t hitung sebesar 2,234 > t Tabel 1,9796, nilai t hitung negatif, dan nilai signifikansi sebesar 0,027 < 0,05. Variabel structural benefit hasilnya berpengaruh secara negatif terhadap loyalitas nasabah dengan nilai t hitung sebesar 2,332 > t Tabel 1,9796, nilai t hitung negatif, dan nilai signifikansi sebesar 0,021 < 0,05. Untuk nilai F sebesar 29,105 > F Tabel sebesar 2,68 dengan nilai signifikansi sebesar 0,000 < 0,05. Sedangkan nilai determinasi nya yang di sesuaikan (Adjusted R Square sebesar 0,403 atau sebesar 40,3 %. Dari analisis data, secara parsial hasilnya financial benefit berpengaruh positif dan signifikan terhadap loyaltas nasabah. Social benefit berpengaruh negatif dan signifikan terhadap loyalitas nasabah. Social benefit berpengaruh negatif dan signifikan terhadap loyalitas nasabah. Sedangkan secara simultan financial benefit, social benefit dan structural benefit berpengaruh positif dan signifikan terhadap loyalitas nasabah.Kata Kunci : Relationship Marketing, Financial Benefit, Social Benefit, Structural Benefit dan Loyalitas Pelanggan

Bacillus thuringiensis Cry1Ca-resistant Spodoptera exigua lacks expression of one of four Aminopeptidase N genes

NARCIS (Netherlands)

Herrero, S.; Gechev, T.; Bakker, P.L.; Moar, W.; Maagd, de R.A.

2005-01-01

BACKGROUND: Insecticidal toxins from Bacillus thuringiensis bind to receptors on midgut epithelial cells of susceptible insect larvae. Aminopeptidases N (APNs) from several insect species have been shown to be putative receptors for these toxins. Here we report the cloning and expression analysis of

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The dilution factor (C/Co) of radionuclide in the sea of Ujung Lemahabang based on open-coast model

International Nuclear Information System (INIS)

Lubis, Erwansyah

1998-01-01

The dilution factor (C/Co) of radionuclide in the sea of Ujung Lemahabang was carried out. The assessment of the (C/Co) was done with the open-coast model. The objective of this assessment is to find the (C/Co) value as function of the distance of the release point. The (C/Co) value can be use for calculation the radiological impact from nuclear power plant during normal and abnormal release. The survey data of Muria peninsula from New-Ject was used in the calculation. The results indicated that the value of (C/Co) in 5.0 to 20 km distance were 4.25 - 5.86 E-07. (author)

Clinical practice: new challenges for the advanced practice nurse.

Science.gov (United States)

Bartel, J C; Buturusis, B

2000-12-01

This report describes the challenges for advanced practice nurses (APNs) relative to supply and demand issues. The article also includes opportunities with the Balanced Budget Act, physician acceptance of Advanced Practice Nurses, and expanding practice opportunities. The challenges include the nursing shortage (both in nursing students and faculty), the aging of the nursing workforce, and a lag in nursing salaries; increased demand for nursing based on aging baby boomers, increasing patient acuity and technology, and new arenas for practice. The Balanced Budget Act of 1997 provided new opportunities for advanced practice nurses, including enhanced autonomy to provide services and bill independently of physicians. With these changes come new opportunities for advanced practice nurse entrepreneurs in the areas of independent practice, including opportunities to positively impact the health of families and communities in alignment with the Federal government's vision for "Healthy People 2010." As physician acceptance of advanced practice nurses continues to grow and in light of the changes in medical practice and education (residency reduction), opportunities to expand collaborative practice arrangements also exist. APNs are best suited to make the most of these changes. One example of an opportunity for independent practice, a Community Wellness Center, is developed as an entrepreneurial venture benefiting both the APN and the health of a community. Who better than registered nurses (RNs), especially those practicing at the advanced level, can ensure that these opportunities and challenges are addressed in an ethical manner and focused on the needs and health of the community?

Penggunaan Accelerometer dan Magnetometer pada Sistem Real Time Tracking Indoor Position untuk Studi Kasus Pada Gedung Teknik Informatika ITS

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Dinar Winia Mahandhira

2017-01-01

Full Text Available Indoor Positioning System (IPS menggunakan perangkat mobile seperti smartphone masih menjadi permasalahan yang menantang. Seperti GPS yang tidak bekerja secara akurat di dalam gedung, IPS juga memiliki kelemahan yaitu sangat bergantung pada infrastruktur gedung seperti sinyal WiFi yang terkadang tidak tersebar secara merata di seluruh bagian gedung, sehingga membuat sistem ini terkadang tidak dapat bekerja secara optimal dan real time di setiap bagian gedung. Untuk itulah dikembangkan IPS yang menggunakan sensor gerak seperti accelerometer dan magnetometer sebagai tambahan untuk melakukan update posisi secara real time dengan mendeteksi langkah dan arah hadap pengguna saat berjalan. Pertama, posisi awal pengguna harus ditentukan terlebih dahulu misalnya menggunakan sinyal WiFi yang diproses melalui klasifikasi. Setelah posisi pengguna telah ditentukan, sistem akan mendeteksi pergerakan pengguna secara real time menggunakan sensor gerak. Uji coba dilakukan menggunakan studi kasus gedung Teknik Informatika lantai tiga. Hasil yang diberikan pada saat pengujian memberikan performa yang cukup baik dengan rata-rata persentase akurasi untuk pendeteksian langkah dan estimasi arah hadap pengguna adalah sebesar 94,8% dan 94,48%.

Model Promosi Kesehatan di Tempat Kerja Multilevel: Bagaimana Implementasinya dalam Mengubah Perilaku Pekerja? (Suatu Kajian Kepustakaan

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Zahtamal .

2015-05-01

Full Text Available Konsekuensi dari penyakit-penyakit yang sering dialami oleh pekerja merupakan kerugian besar bagi perusahaan dan pekerja. Dalam rangka mengatasi persoalan penyakit pada pekerja, perlu upaya promosi kesehatan di tempat kerja, khususnya untuk mengubah perilaku. Penerapan perubahan perilaku di tempat kerja bersifat lebih kompleks. Perubahan perilaku tidak saja didorong oleh faktor-faktor individu, tetapi juga oleh peran faktor eksternal, sehingga pihak yang dijadikan sasaran workplace health promotion (WHP adalah secara multilevel. Artikel ini menjelaskan rumusan model WHP multilevel yang dapat diterapkan untuk mengubah perilaku pekerja yang tidak sehat, sehingga diharapkan dapat menurunkan kesakitan dan kematian penyakit pada pekerja. Prinsip pemilihan model perubahan perilaku, perlu  diperhatikan dalam merumuskan WHP secara multilevel. Hal ini dijadikan sebagai acuan memodifikasi perilaku yang akan dituju. Selanjutnya, prinsip memilih strategi dan metode perubahan perilaku, disesuaikan dengan level sasaran yang diintervensi. Secara keseluruhan, prinsip-prinsip ini dirumuskan dalam sebuah acuan program WHP secara komprehensif dan dilaksanakan dengan efektif dan efisien di tempat kerja. Artikel ini dapat menjadi acuan bagi pihak yang akan mengimplementasikan WHP dengan pendekatan perubahan perilaku secara multilevel. 

DAMPAK PACARAN SECARA HOLISTIK TERHADAP REMAJA

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Hikmah Hikmah

2014-04-01

Full Text Available Thisstudy aims at knowing the impact of going to the physical, psychological, social, spiritual (holistic inclass X and XI in MAN 1 Wates in 2013. The reason this research because the results obtained from in-depth interviews in 4 students MAN 1 Wates lackof knowledge about the courtship activities and impactso there are irregularities in the reproductive organs as well as the impact of physical,psychological,social and spiritual students. The method used by the Qualitative Quantitative Descriptivesampling technique used "Simple Random Sampling". Quantitative respondents in this study werestudents of class X and XI as many as 181 people, while respondents in-depth qualitative interviews withas many as 4 people. The results showed that there is going to impact as much as 75.2 % physical, 74%psychological, social as much as 73.5 %, 76.7 % and spiritual as much as 52.5 % holistic impact. ForMAN 1 Wates is expected to provide the facilities and infrastructure to provide information onreproductive health knowledge and prevention of courtship holistic impact both on the parents and to thestudents directly through counseling and peer group .

PERANCANGAN MESIN PENYAYAT BAMBU SECARA ERGONOMIS

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Agung Kristanto

2012-12-01

Full Text Available Jamboel Kipas adalah UKM yang memproduksi souvenir kipas dengan sistem pesanan make to order. Seiring perkembangan waktu, Jamboel Kipas tidak dapat memenuhi pesanan karena keterbatasan kapasitas produksi souvenir kipas. Hal ini disebabkan karena waktu proses yang lama terjadi pada bagian penyayatan bambu, yaitu sebesar 22 detik/iratan. Penelitian ini ditujukan untuk meningkatkan produktivitas penyayatan bambu serta memperbaiki posisi operator saat bekerja, dengan perancangan mesin penyayat bambu berdasar anthropometri ukuran tubuh operator, keluhan selama bekerja, dan waktu proses penyayatan bambu. Hasil penelitian setelah perancangan menunjukan posisi operator saat bekerja cukup ergonomis karena ukuran tempat kerja disesuaikan dengan dimensi antropometri operator. Waktu baku pada kondisi sebelum perancangan sebesar 21,16 detik/iratan dan output standar sebesar 170,09 iratan/jam. Sedangkan setelah perancangan sebesar 4,42 detik/iratan dan output standarnya sebesar 815,22 iratan/jam dengan peningkatan output standar 479,46%, terjadi penurunan waktu baku sebesar 378,73%. Sementara itu nilai break event point terjadi ketika UKM Jamboel Kipas sudah memproduksi 12927 kipas.

PERANCANGAN MESIN PENYAYAT BAMBU SECARA ERGONOMIS

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Agung Kristanto

2012-12-01

Full Text Available Jamboel Kipas adalah UKM yang memproduksi souvenir kipas dengan sistem pesanan make to order. Seiring perkembangan waktu, Jamboel Kipas tidak dapat memenuhi pesanan karena keterbatasan kapasitas produksi souvenir kipas. Hal ini disebabkan karena waktu proses yang lama terjadi pada bagian penyayatan bambu, yaitu sebesar 22 detik/iratan. Penelitian ini ditujukan untuk meningkatkan produktivitas penyayatan bambu serta memperbaiki posisi operator saat bekerja, dengan perancangan mesin penyayat bambu berdasar anthropometri ukuran tubuh operator, keluhan selama bekerja, dan waktu proses penyayatan bambu. Hasil penelitian setelah perancangan menunjukan posisi operator saat bekerja cukup ergonomis karena ukuran tempat kerja disesuaikan dengan dimensi antropometri operator. Waktu baku pada kondisi sebelum perancangan sebesar 21,16 detik/iratan dan output standar sebesar 170,09 iratan/jam. Sedangkan setelah perancangan sebesar 4,42 detik/iratan dan output standarnya sebesar 815,22 iratan/jam dengan peningkatan output standar 479,46%, terjadi penurunan waktu baku sebesar 378,73%. Sementara itu nilai break event point terjadi ketika UKM Jamboel Kipas sudah memproduksi 12927  kipas.

Perawatan Kasus Diastema Multipel Secara Multidisiplin

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Fadli Jazaldi

2012-10-01

Full Text Available Diastemas are spaces or gaps between two or more consecutive teeth. They can occur anywhere in the upper or lower dental arches. Diastemas can occur in mixed dentition and closes spontaneously when the canines erupt, but in certain circumstances, diastema will persist until period of permanent teeth. This etiologic factor has to identify because it will influenc effectivenees of closing the multiple diastemas. The multiple diastemas that happened at the anterior upper and lower which caused by deficient tooth structure and missing of some teeth (agenesis, accompanied of central diastema which influenced by anterior labialis frenulum, should treated comprehensively. Treatment of this case entangle ortodontic, periodontic, conservative dentistry, and prostodontic. Reposition of abnormal frenulum attachment (frenectomy, arrangement of occlusion and teeth interdigitation, getting continuity of dental arch through achieving good approximal teeth contact by crown reshaping andreplaced of missing tooth element with prothesis, and then making of retainer to maintain stability of treatment result are serial of treatments for the case. By cooperation of multidicipline proffesionals, the final result is to obtain the optimal esthetics, functional, and stability result of  treatment, will achived.DOI: 10.14693/jdi.v15i3.29

PENYEBARAN INFORMASI MENGGUNAKAN WWW (WORLD WIDE WEB

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Ika Atman Satya

2011-12-01

Full Text Available Media Informasi secara tradisional telah kita kenai dengan menggunakan koran, televisi, radio dan buku referensi. Media informasi tersebut untuk penyebarannya memerlukan penunjang agar informasi tersebut dapat disebarkan secara lutis. Selain penggunaan media tradisional tersebut penyebaran informasi dengan menggunakan jaringan komputer Internet juga berkembang. Salah satu cara penyebaran informasi dengan menggunakan aplikasi WWW (World Wide Web yang mempunyai kemampuan menggabungkan gambar, text dan suara secara interaktif. Pada tulisan ini akan dibahas tentang kemampuan, penggunaan dan pengembangan server WWW.

PENGAJARAN BAHASA DENGAN PENDEKATAN KOMUNIKATIF: Analisis atas Teori Transformatif-Generatif Noam Chomsky

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Alif Cahya Setiadi

2016-08-01

Full Text Available Sebagai alat interaksi verbal, bahasa dapat dikaji secarainternal maupun secara eksternal. Secara internal kajian dilakukanterhadap struktur internal bahasa itu mulai dari strukturfonologi, morfologi, sintaksis, sampai struktur wacana. Kajiansecara eksternal berkaitan dengan hubungan bahasa denganfaktor-faktor atau hal-hal yang ada di luar bahasa, seperti faktirsosial, psikologi, seni dan sebagainya.Pembelajaran bahasa sebagai salah satu masalah komplekmanusia karena hal ini termasuk kajian bahasa internal maupuneksternal yang berkenaan dengan masalah bahasa dan kegiatanberbahasa. Sedangkan kegiatan berbahasa itu bukan hanyaberlangsung secara mekanistik tetapi juga secara mentalistik.Artikel ini mencoba menguraikan suatu bentuk pendekatankomunikatif yang diusung dalam teori transformativegeneratifmenurut Noam Chomsky, seorang linguis Amerika.Hal ini diharapan agar pembelajaran bahasa mampu memperkayapendekatan yang digunakan dalam pembelajaran bahasadan tidak terpaku pada satu jenis pendekatan yang selama inidigunakan. Sehingga mampu menghadirkan suasana belajarbahasa yang komunikatif dan mencapai sasaran.

Estudo comparativo da história clínica e da polissonografia na síndrome da apnéia/ hipopnéia obstrutiva do sono Comparative study between clinical history and polysomnogram in the obstructive sleep apnea/ hypopnea syndrome

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Lys Maria Allenstein Gondim

2007-12-01

Full Text Available O reconhecimento dos distúrbios respiratórios do sono tem aumentado a cada ano. Manifestações, como o ronco, consideradas meros incômodos vêm adquirindo importância no que diz respeito à qualidade de vida e seu impacto social. OBJETIVO: Comparar a história clínica com os resultados da polissonografia (PSG, na Síndrome da Apnéia/Hipopnéia Obstrutiva do Sono (SAHOS, é o principal objetivo deste trabalho. MATERIAL E MÉTODOS: Foi realizado um estudo retrospectivo, com 125 pacientes, através da análise de questionários específicos, IMC e Escala de Epworth. RESULTADOS: Dentre os pacientes, 75 eram do sexo masculino e 50 do feminino. O principal sintoma foi a roncopatia. 46% apresentaram PSG normais, 30% SAHOS leve, 15% moderada e 9% severa, não se evidenciando correlação estatística entre a clínica e a PSG. Dentre as queixas, somente a insônia foi relevante, em análise univariada e em pacientes normais e com SAHOS leve (pRecognizing sleep-disordered breathing is on the rise every year. Manifestations, such as snoring, that were earlier considered mere inconvenients are now acquiring greater importance concerning life quality and social impact. AIM OF THE STUDY: To compare the clinical history to polysomnogram (PSG results in the Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS. MATERIALS AND METHODS: 125 patients were analyzed, in a retrospective study. Specific questionnaires, avaliations of Body Mass Index and Epworth Scale were carried out. RESULTS: Among the patients, 75 were males and 50 were females. The main symptom was snoring. 46% had normal PSG, 30% had light OSAHS, 15% moderate and 9% severe OSAHS and it was not observed a correlation between clinical data and PSG results. Concerning clinical symptoms, only insomnia has shown relevance when univariably analyzed in normal and light OSAHS patients (p<0,05 compared to patients with moderate and severe OSAHS, losing its importance when analyzed together with other

Survey of public participation potential regarding the Muria NPP program

International Nuclear Information System (INIS)

Yarianto-SBS; Sri Hariani Syarif; Heni Susiati; Imam Hamzah; Fepriadi

2003-01-01

Socio-culture aspect is a part of site feasibility evaluation of Nuclear Power Plant (NPP)program. Indonesia is under going democratization, therefore the paradigm of development has also been changed where the people have freedom or liberty and they can express their opinion independently. The people are significant factor that involving in the decision making of regional development.Even the socio-culture, such as social riot can reject the site. Therefore socio-culture aspect should be considered in the NPP site evaluation. The first step of the study,mapping of public participation potential should be conducted by field survey. The method used in there search is quantitative approach with field survey guided by questioner without any treatment of object sampled. Qualitative approach was also conducted by in-depth interview technique to collect more detailed information. Information were collected from general public without any stratification in the 10 km radius from NPP site. Sampling method used was full random sampling technique. The results of survey show that the most of the people have significant potential for participating in the NPP Program. Conducive atmosphere should be maintained by social setting, therefore the present good momentum will not be lost. (author)

27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation

Science.gov (United States)

Mateos, Laura; Maioli, Silvia; Ali, Zeina; Gulyás, Balázs; Winblad, Bengt; Savitcheva, Irina

2017-01-01

Hypercholesterolemia is associated with cognitively deteriorated states. Here, we show that excess 27-hydroxycholesterol (27-OH), a cholesterol metabolite passing from the circulation into the brain, reduced in vivo brain glucose uptake, GLUT4 expression, and spatial memory. Furthermore, patients exhibiting higher 27-OH levels had reduced 18F-fluorodeoxyglucose uptake. This interplay between 27-OH and glucose uptake revealed the engagement of the insulin-regulated aminopeptidase (IRAP). 27-OH increased the levels and activity of IRAP, countered the IRAP antagonist angiotensin IV (AngIV)–mediated glucose uptake, and enhanced the levels of the AngIV-degrading enzyme aminopeptidase N (AP-N). These effects were mediated by liver X receptors. Our results reveal a molecular link between cholesterol, brain glucose, and the brain renin-angiotensin system, all of which are affected in some neurodegenerative diseases. Thus, reducing 27-OH levels or inhibiting AP-N maybe a useful strategy in the prevention of the altered glucose metabolism and memory decline in these disorders. PMID:28213512

Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension

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John W. Wright

2012-01-01

Full Text Available The classic renin-angiotensin system (RAS was initially described as a hormone system designed to mediate cardiovascular and body water regulation. The discovery of a brain RAS composed of the necessary functional components (angiotensinogen, peptidases, angiotensins, and specific receptor proteins independent of the peripheral system significantly expanded the possible physiological and pharmacological functions of this system. This paper first describes the enzymatic pathways resulting in active angiotensin ligands and their interaction with AT1, AT2, and mas receptor subtypes. Recent evidence points to important contributions by brain angiotensin III (AngIII and aminopeptidases A (APA and N (APN in sustaining hypertension. Next, we discuss current approaches to the treatment of hypertension followed by novel strategies that focus on limiting the binding of AngII and AngIII to the AT1 receptor subtype by influencing the activity of APA and APN. We conclude with thoughts concerning future treatment approaches to controlling hypertension and hypotension.

PERENCANAAN LOKASI SITE BTS LAYANAN 3G-WCDMA DI PEMERINTAH KOTA DENPASAR DENGAN MEMANFAATKAN BALAI BANJAR

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I Wayan Aryadi

2015-03-01

Full Text Available Seiring dengan perkembangan kebutuhan bit rate dan kapasitas layanan data yang meningkat di wilayah Kota Denpasar, diperlukan perencanaan lokasi site BTS (Base Transceiver Station yang dapat melayani kebutuhan pelanggan secara kuantitas maupun kualitas. Untuk memperoleh nilai bit rate yang maksimal dibutuhkan jari-jari sel yang kecil. Dengan perbandingan luas wilayah sebesar 130,48 km2 jika dibagi dengan 399 balai banjar di Kota Denpasar maka diperoleh coverage area 0,327 km2 per banjar dengan jari-jari sel sekitar 285 m. Maka pada penelitian ini lokasi site BTS yang digunakan adalah pada Balai Banjar di Kota Denpasar. Tujuan penelitian ini adalah untuk merancang lokasi site BTS layanan 3G-WCDMA (Wideband Code Division Multiple Access untuk wilayah Pemerintah Kota Denpasar sesuai data sebaran penduduk dan mengetahui perbandingan jumlah site BTS secara teoritis untuk layanan 3G-WCDMA memanfaatkan Balai Banjar Pemerintah Kota Denpasar dengan model pemetaan secara geografis. Metode penelitian terdiri dari 3 alur, yaitu perkiraan pertumbuhan pelanggan 3G-WCDMA dan Offered Bit Quantity (OBQ per desa di Kota Denpasar, Perhitungan jumlah dan jari-jari site secara teoritis per desa di Kota Denpasar, dan Pemetaan site di Kota Denpasar memanfaatkan Balai Banjar. Perhitungan secara teoritis menunjukkan bahwa 257 site yang diperlukan untuk melingkupi seluruh wilayah Denpasar. Sementara pemetaan secara geografis dengan memanfaatkan lokasi Balai Banjar adalah sebanyak 311 site. Dari 311 site, 155 site (49,84% terdapat pada kawasan Balai Banjar dan 156 site (50,16% terdapat di luar kawasan Balai Banjar.

Desain dan Aplikasi Internet of Thing (IoT untuk Smart Grid Power Sistem

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Nur Asyik Hidayatullah

2017-04-01

Full Text Available Jaringan listrik cerdas atau yang lebih dikenal dengan istilah Smart Grid merupakan salah satu bentuk transformasi dan reformasi teknologi di industri ketenagalistrikan. Smart Grid adalah jaringan energi listrik modern yang secara cerdas dapat mengintegrasikan jaringan listrik dengan perangkat komunikasi yang mendukung pembangkit dan jaringan transmisi distribusi listrik menjadi lebih atraktif, komunikatif dan berkualitas. Smart Grid juga mampu untuk mencegah dan mengisolasi gangguan dengan cepat serta menyajikan informasi data kelistrikan secara real time. Sedangkan Internet of Thing (IoT adalah sebuah metode yang bertujuan untuk memaksimalkan manfaat dari konektivitas internet untuk melakukan transfer dan pemrosesan data-data atau informasi melalui sebuah jaringan internet secara nirkabel, virtual dan otonom. IoT secara teknis dapat mendorong dalam mengembangkan jaringan smart grid dengan mengintegrasikan insfrastruktur utama power sistem mulai dari sisi pembangkit sampai dengan konsumen akhir melalui wireless sensor network secara otomatis. Dengan pemanfaatan IoT diharapkan dapat meningkatkan keandalan sistem informasi dari jaringan listrik serta meningkatkan efisiensi terhadap insfrastruktur listrik yang sudah tersedia. Artikel ini akan menyajikan konsep teknologi smart grid, internet of thing dan membahas model desain dan aplikasi IoT di jaringan smart grid.

REGULATION ON FOREIGN INVESTMENT RESTRICTIONS AND NOMINEE PRACTICES IN INDONESIA

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David Kairupan

2014-03-01

Full Text Available Certain provisions of Presidential Regulation No. 36 of 2010 concerning Negative Investment List are not clearly stipulated. In relation to the restrictions of foreign investment in certain business sectors asspecified in the Negative Investment List Article 33 para. (1 and (2 of the 2007 Investment Law expressly prohibits investors from entering into any nominee shareholding documentation. Notwithstanding, manynominee shareholding practices are still employed in Indonesia, aiming to circumvent such restrictions.This paper addresses certain issues on Presidential Regulation No. 36 of 2010 and nominee shareholding practices in Indonesia. Beberapa ketentuan dalam peraturan Presiden No. 36 Tahun 2010 yang mengandung ketentuan Daftar Negatif Investasi tidak dirumuskan secara jelas. Sehubungan dengan pembatasan kepemilikan modal asing di beberapa sektor usaha, Pasal 33 ayat (1 dan (2 Undang-Undang Penanaman Modal No. 25 Tahun 2007 secara tegas melarang penanam modal membuat dokumen-dokumen yang terkait dengankepemilikan saham secara nominee. Namun demikian, praktik kepemilikan saham secara nominee masih sering dilakukan di Indonesia untuk menghindari pembatasan tersebut. Tulisan ini akan membahasbeberapa permasalahan yang berhubungan dengan Peraturan Presiden No. 36 Tahun 2010 dan praktek kepemilikan saham secara nominee di Indonesia.

Implementasi Estimator Kecepatan Pertumbuhan Mikroorganisme pada Bioreaktor Anaerob

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Dewinta Ria Wardhani

2013-03-01

Full Text Available Mikroba memiliki peranan yang sangat penting dalam produktivitas biogas pada pengolahan limbah bahan organik khususnya kotoran ternak pada bioreaktor anaerob, dimana dalam pengolahanya bakteri dipengaruhi oleh nutrisi, pH dan temperatur. Sehingga akan mempengaruhi produk biogas yang dihasilkan. Agar mendapatkan hasil biogas yang diharapkan maka diperlukan sebuah monitoring kecepatan pertumbuhan mikroorganisme. Namun saat ini belum ada alat untuk memonitoring secara langsung sehingga diperlukan sebuah estimator untuk memprediksi pertumbuhan mikroorganisme, untuk memprediksi pertumbuhan mikroorganisme berdasarkan parameter pH dan volume yang diukur. Estimator bekerja berdasarkan model matematis dengan menggunakan Jaringan Syaraf Tiruan arsitektur Backpropagation dengan metode Lavenberg Marquardt. Estimator yang telah dihasilkan secara offline memiliki input berupa pH dan volume yang dianalogikan melalui tegangan dari potensiometer. Pada penelitian ini akan di implementasikan estimator kecepatan pertumbuhan mikroorganisme (µ secara online pada bioreaktor anaerob yang digunakan untuk mengekstrak kotoran ternak. Dari pengukuran secara online dan offline didapatkan nilai µ terbaik pada pengukuran secara online yaitu 7,5 pada pH 7,45 dan volume 0,05 L sedangkan nilai µ terbaik pada simulasi 7,3092 pada pH 5,47 dan volume 0,0106 L

KONTRIBUSI KETERLIBATAN SISWA DI UNIT PRODUKSI DAN EMPLOYABILITY SKILLS TERHADAP SELF EFFICACY SERTA DAMPAKNYA PADA MINAT BEKERJA SISWA SMK

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Fitria Nur Hasanah

2016-01-01

Full Text Available Tujuan penelitian untuk mengetahui kontribusi: (1 keterlibatan siswa di Unit Produksi/Jasa (UPJ dan employability skill secara simultan dan parsial terhadap self efficacy; (2 secara simultan dan parsial antara keterlibatan siswa di UPJ, employ-ability skills, dan self efficacy terhadap minat bekerja. Penelitian ini adalah jenis sur-vei korelasional. Populasi penelitian adalah siswa SMK kelas XII Kompetensi Keahli-an TKJ di Malang Raya. Teknik pengumpulan data dengan angket dan dianalisis de-ngan analisis jalur. Hasil penelitian ini adalah keterlibatan siswa di UPJ dan employ-ability skills secara simultan berkontribusi terhadap self efficacy sebesar 54,60%. Ke-mudian keterlibatan siswa di UPJ, employability skills, dan self efficacy secara simul-tan berkontribusi terhadap minat bekerja siswa sebesar 53,80%. Variabel keterlibatan siswa di UPJ, employability skills, dan self efficacy masing-masing juga berkontribusi terhadap minat bekerja.

76 FR 2710 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

Science.gov (United States)

2011-01-14

..., APN and ICONMA, Winston-Salem, North Carolina. The notice was published in the Federal Register on... Seaton Corporation. The notices were published on the Federal Register on April 19, 2010 (75 FR 20385... workers are engaged in employment related to the production of desktop computers. New information shows...

Pemodelan Matematik Kinerja Pengering Surya Efek Rumah Kaca (ERK-Hibrid Menggunakan Rak Berputar secara Vertikal (Mathematical Modeling Performance of Greenhouse Effect (GHE-Hybrid Solar Dryer with a Vertical Rotating Rack

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Sigit Triwahyudi

2016-12-01

ini menyajikan uji unjuk kerja dan pemodelan matematik pengering energi surya (ERK-Hibrid  menggunakan  rak berputar secara vertikal. Pengering terdiri dari bangunan rumah kaca berukuran (1100 × 860 × 1300 mm dengan delapan buah rak dan sistim pemanas tambahan yang terdiri dari kolektor plat datar (1,04 m2, tangki penyimpan air panas (197 liter dan penukar panas. Untuk mengetahuikinerja pengering energi surya, dilakukan lima kali percobaan variasi kecepatan putar rak (1, 4, 7, 10 rpm dan tanpa pemutaran rak. Bahan yang dipergunakan pada pengujian adalah kapulaga lokal (Amomum cardamomum Wild. Masing-masing percobaan seberat 9 sampai dengan 10 kg. Rata-rata suhu air tangki penyimpan panas bervariasi dari 50,0 sampai dengan 55,0 °C suhu ruang pengering antara 38,9 sampai dengan 45,9 °C, sedangkan kelembaban relatif (RH ruang pengering berkisar antara 32,1 sampai dengan 47,4 %. Perlakuan pemutaran rak berpengaruh terhadap keseragaman suhu bahan maupun kadar air pada masing rak pengering. Pada perlakuan pemutaran 1 rpm (percobaan II, didapatkan kondisi terbaik (suhu bahan maupun kadar air yang paling seragam. Dengan kecepatan putar rak yang semakin meningkat menyebabkan nilai ragam suhu bahan maupun kadar air semakin meningkat. Untuk melakukan simulasi unjuk kerja dilakukan pemodelan matematik berdasarkan pindah panas dan massa serta pendekatan pengeringan lapisan tipis. Persamaan diselesaikan secara numerik menggunakan finite difference Euler dengan bantuan bahasa pemrograman Visual Basic Aplication (VBA Excell. Validasi dilakukan dengan membandingkan antara perhitungan hasil pemodelan (data prediksi dengan data hasil pengukuran (data observasi. Kriteria kevalidan ditentukan dengan melihat nilai koefisien determinasi (R2, nilai RMSD maupun nilai MAPD. Pemodelan  matematik yang telah dibangun dapat menggambarkan dengan tepat perubahan suhu air tangki penyimpan panas, suhu ruang pengering, suhu bahan maupun penurunan kadar air. Kata kunci: Pengering surya efek rumah

Usefulness of analytical parameters in the management of paediatric patients with suspicion of acute pyelonephritis. Is procalcitonin reliable?

Science.gov (United States)

Bañuelos-Andrío, L; Espino-Hernández, M; Ruperez-Lucas, M; Villar-Del Campo, M C; Romero-Carrasco, C I; Rodríguez-Caravaca, G

To investigate the usefulness of procalcitonin (PCT) and other analytical parameters (white blood cell count [WBC], C-reactive protein [CRP]) as markers of acute renal damage in children after a first febrile or afebrile urinary tract infection (UTI). A retrospective study was conducted on children with a first episode of UTI admitted between January 2009 to December 2011, and in whom serum PCT, CRP and white blood cell count were measured, as well as assessing the acute renal damage with renal scintigraphy with 99m Tc-DMSA (DMSA) within the first 72h after referral. A descriptive study was performed and ROC curves were plotted, with optimal cut-off points calculated for each parameter. The 101 enrolled patients were divided into two groups according to DMSA scintigraphy results, with 64 patients being classified with acute pyelonephritis (APN), and 37 with UTI. The mean WBC, CRP and PCT values were significantly higher in patients with APN with respect to normal acute DMSA. The area under the ROC curve was 0.862 for PCR, 0.774 for WBC, and 0.731 for PCT. The optimum statistical cut-off value for PCT was 0.285ng/ml (sensitivity 71.4% and specificity 75%). Although the mean levels of fever, WBC, CRP, and PCT were significantly increased in patients with APN than in those who had UTI, the sensitivity and specificity of these analytical parameters are unable to predict the existence of acute renal damage, making the contribution by renal DMSA scintigraphy essential. Copyright © 2016 Elsevier España, S.L.U. y SEMNIM. All rights reserved.

Self Assessment for the Safety of Research Reactor in Indonesia

International Nuclear Information System (INIS)

Melani, Ai; Chang, Soon Heung

2008-01-01

At the present Indonesia has no nuclear power plant in operation yet, although it is expected that the first nuclear power plant will be operated and commercially available in around the year of 2016 to 2017 in Muria Peninsula. National Nuclear Energy Agency (BATAN) has three research reactor; which are: Reactor Triga Mark II at Bandung, Reactor Kartini at Yogyakarta and Reactor Serbaguna (Multi Purpose Reactor) at Serpong. The Code of Conduct on the Safety of Research Reactors establishes 'best practice' guidelines for the licensing, construction and operation of research reactors. In this paper the author use the requirement in code of conduct to review the safety of research reactor in Indonesia

Estimating long-term volatility parameters for market-consistent models

African Journals Online (AJOL)

Contemporary actuarial and accounting practices (APN 110 in the South African context) require the use of market-consistent models for the valuation of embedded investment derivatives. These models have to be calibrated with accurate and up-to-date market data. Arguably, the most important variable in the valuation of ...

Penerapan Konsep “7 Habits of Highly Effective People” dalam Profesi Dosen

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Yusuf Hamdan

2003-06-01

Full Text Available Terdapat tujuh kebiasaan yang diajukan Stephen R. Covey agar hidup manusia efektif, yakni hidup proaktif sebagai visi pribadi, memulai dengan gambaran akhir kehidupan sebagai bentuk kepemimpinan pribadi, mendahulukan yang utama sebagai bentuk kemampuan melakukan prioritas, berpikir menang-menang dalam menjalankan kepemimpinan antarpribadi, mengerti orang lain terlebih dahulu baru kemudian akan dimengerti orang lain, melakukan sinergi berkomunikasi secara efektif dan kreatif, dan memperbarui diri secara terus-menerus. Ketujuh habit tersebut sangat relevan diimplementasikan dalam kehidupan profesi dosen. Tiga habit yang pertama merupakan hal-hal yang perlu dimiliki dosen untuk mengefektifkan dirinya secara internal dalam menyikapi tugas-tugasnya sebagai dosen. Tiga habit berikutnya merupakan hal-hal penting bagi dosen untuk mengefektifkan dirinya secara eksternal, dalam hubungannya dengan sesama dosen, mahasiswa, dan pihak lainnya. Habit yang terakhir merupakan hal penting untuk mengembangkan kepekaan seorang dosen dalam upaya mengantsipasi berbagai perubahan dalam profesi yang dijalaninya.

KAJIAN STRATEGI PROMOSI KESEHATAN SANITASI TOTAL BERBASIS MASYARAKAT (STBM DI KELURAHAN TIRTO KECAMATAN PEKALONGAN BARAT KOTA PEKALONGAN

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Yulis Indriyani

2016-07-01

Full Text Available Latar Belakang: Sanitasi Total Berbasis Masyarakat (STBM merupakan pendekatan untuk mengubah perilaku higienis dan saniter melalui pemberdayaan masyarakat dengan cara pemicuan. Fenomena yang terjadi di Kelurahan Tirto masih terdapat perilaku BABS sebanyak 84 KK, perilaku buang sampah secara sembarangan (di lahan kosong dan sungai, dan mengalirkan limbah cair rumah tangga (limbah deterjen dan air bekas mandi ke sungai. Tujuan penelitian: Mengkaji secara mendalam strategi promosi kesehatan (advokasi, bina suasana, dan pemberdayaan masyarakat STBM di Kelurahan Tirto Kecamatan Pekalongan Barat Kota Pekalongan. Rancangan penelitian ini menggunakan metode studi kasus dengan desain eksploratoris kualitatif. Hasil penelitian: Pencapaian lima pilar  STBM di Kelurahan Tirto belum maksimal yaitu pada pilar stop BABS dan pilar pengelolaan limbah cair rumah tangga secara aman. Terdapat beberapa hambatan yang mempengaruhi hasil capaian tersebut diantaranya konsistensi komitmen yang tegas belum diterapkan bagi pelaku yang mengalirkan pembuangan feses ke sungai, belum adanya pelatihan teknis STBM bagi tokoh masyarakat, metode CLTS bersifat terbatas di satu RW, dan masyarakat Kelurahan Tirto belum mengoptimalkan swadaya atau iuran secara kolektif untuk menyediakan penambahan sarana sanitasi berupa septic tank dan bak penampungan. Saran: Pertama, penerapan punishment dari Kelurahan Tirto untuk mencapai Kelurahan ODF bagi pelaku yang mengalirkan pembuangan feses ke sungai. Kedua, pertemuan untuk menjalin koordinasi antara Pemerintah Kota Pekalongan dan Pemerintah Kabupaten Pekalongan untuk bersama mengelola limbah cair rumah tangga secara aman. Ketiga,  pelatihan teknis STBM bagi tokoh masyarakat untuk mencapai perilaku buang air besar secara sehat di Kelurahan Tirto. Keempat, penambahan bak penampungan limbah cair rumah tangga melalui swadaya masyarakat.

PRELIMINARY STUDY ON RELAP5 SIMULATION OF DVI LINE BREAK ACCIDENT IN THE ATLAS FACILITY USING BEST ESTIMATE PLUS UNCERTAINTY METHOD

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Andi Sofrany Ekariansyah

2017-03-01

STUDI AWAL SIMULASI KECELAKAAN PUTUSNYA JALUR DVI PADA FASILITAS ATLAS MENGGUNAKAN RELAP5 DENGAN METODE ESTIMASI TERBAIK DAN KETIDAKPASTIAN. Metode Best estimate plus uncertainty (BEPU adalah metode analisis keselamatan deterministik yang bertujuan untuk melakukan evaluasi keterbatasan program perhitungan dalam mensimulasikan sifat-sifat fisis instalasi secara realistik dengan mengkuantifikasi rentang ketidakpastian dari hasil perhitungan. Metode tersebut telah diterima secara luas dalam perijinan PLTN oleh badan pengatur dunia seperti di Amerika (USNRC, di Argentina, dan Kanada. Evaluasi ketidakpastian dalam metode BEPU dilakukan dengan beberapa metode yang berbeda seperti GRS, IRSN, ENUSA, AEAT, dan UNIPI. Atas dasar kompleksitas metode-metode yang lain, tujuan makalah ini adalah untuk menggambarkan aspek penting dari proses BEPU dengan metode GRS dengan melakukan simulasi putusnya jalur DVI sebesar 50% luasan pada fasilitas ATLAS karena analisis keselamatan yang dilakukan selama ini baru berupa perkiraan terbaik secara deterministik. Sebagai perbandingan dari simulasi perkiraan terbaik yang dilakukan dengan RELAP5/SCDAP/Mod3.4 digunakan data-data eksperimen yang telah terdokumentasi. Setelah dilakukan 100 simulasi, rentang ketidakpastian dari transien temperatur puncak kelongsong pemanas dan tekanan primer hanya mendekati data eksperimen pada 250 detik di periode awal. Oleh karena itu keakuratan dari simulasi perkiraan terbaik secara keseluruhan memiliki peranan penting pada hasil akhir dari analisis ketidakpastian karena perambatan perbedaan dengan data eksperimen akan terus terjadi selama simulasi. Setelah itu, pemilihan parameter yang penting untuk dikembangkan secara random harus dilakukan secara cermat dengan mempelajari fenomena-fenomena penting yang terkait dengan kejadian yang dianalisis dan model instalasinya. Kata kunci: perkiraan terbaik dan ketidakpastian, putusnya jalur DVI, fasilitas ATLAS, RELAP5, simulasi

PENULISAN SEJARAH SOSIAL

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HARIANTI Harianti

2015-11-01

sial, studi tentang kota perkotaan atau sejarah sosial kota dan sebagainya. Langkah-langkah penulisan sejarah sosial meliputi empat kegiatan pokok yakni : Heuristik, Kritik, lnterpretasi dan Penyajian. Penulisan sejarah sosial tidak ditulis secara diskriptif, melainkan harus disusun secara analisis agar merupakan penulisan sejarah yang bersifat ilmiah.

Pendugaan Struktur Patahan Dengan Metode Gaya Berat

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Ibrahim Sota

2011-12-01

Full Text Available Telah dilakukan penelitian tentang pendugaan struktur patahan mengguankan metode gayaberat. Kontras densitas tersebut berasosiasi dengan ketebalan sedimen dan keberadaan struktur patahan atau lipatan. Untuk mengetahui lokasi patahan dan lipatan maka anomali residual terlebih dahulu dipisahkan dari anomali total (anomali Bouguer dengan metode perata-rataan bergerak. Kontur anomali residual memperlihatkan keberadaan lipatan dan patahan secara kualitatif sedangkan interpretasi kuantitatif dengan pemodelan kedepan 2D memperlihatkan secara jelas lokasi patahan. Dari hasil penelitian diperoleh bahwa lokasi patahan/sesar naik berada di bagian timurlaut yang berorientasi baratlaut-tenggara sedangkan patahan/sesar normal tersebar secara lokal yang juga berorientasi baratlaut-tenggara.

Intensi berwirausaha mahasiswa: Perspektif pengambilan risiko

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Tony Wijaya

2016-04-01

Full Text Available Penelitian  yang  dilakukan  bertujuan  untuk  menguji  1  pengaruh  sikap berwirausaha  terhadap intensi berwirausaha, 2 pengaruh efikasi diri terhadap intensi berwirausaha, 3 pengaruh norma subjektif terhadap intensi berwirausaha, 4 pengaruh kecenderungan mengambil risiko terhadap sikap berwirausaha, dan 5 pengaruh kecenderungan mengambil risiko terhadap efikasi diri. Penelitian yang dilakukan bersifat kuantitatif dan merupakan penelitian cross-sectional. Populasi dalam pemelitian ini adalah mahasiswa di DIY. Teknik sampling menggunakan purposive sampling dengan kriteria mahasiswa semester akhir atau minimal semester 6 dengan pertimbangan pengambilan keputusan setelah lulus. Banyaknya sampel penelitian ini 436. Pengujian model analisis data dengan menggunakan persamaan struktural atau SEM yang dibantu dengan program AMOS. Hasil penelitian menunjukkan bahwa secara keseluruhan model intensi  berwirausaha dalam penelitian ini memenuhi kaidah fit model yang berarti model yang dikembangkan dalam penelitian ini sesuai dengan kondisi empirik yang ada. Kecenderungan mengambil risiko memengaruhi self efficacy secara signifikan, kecenderungan mengambil risiko memengaruhi sikap berwirausaha secara signifikan, norma subjektif tidak memengaruhi intensi berwirausaha secara signifikan (norma subjektif sebagai faktor eksternal tidak memiliki kontribusi dalam mendorong minat mahasiswa untuk berwirausaha, mahasiswa lebih terdorong oleh aspek internal seperti kemampuan diri dan sikap dalam mengevaluasi kegiatan berwirausaha, dan self-efficacy memengaruhi intensi berwirausaha secara signifikan.

Efektivitas Pengolahan Air Limbah Batik dengan Cara Kimia dan Biologi

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Istihanah Nurul Eskani

2016-04-01

Full Text Available Kebanyakan industri batik membuang air limbah ke lingkungan tanpa diolah terlebih dahulu dengan alasan keterbatasan tempat, dana dan penguasaan teknologi. Beberapa cara pengolahan air limbah telah dilakukan untuk mengatasi penurunan mutunlingkungan akibat pembuangan air limbah.Telah dilakukan penelitian proses pengolahan air limbah batik secara kimia, biologi aerob dan biologi anaerob. Proses kimia dilaksanakan dengan menambahkan koagulan tawas dan kapur ke dalam air limbah batik. Proses biologi aerob dijalankan dalam reaktor terbuka selama 5 hari, sedang proses biologi anaerob  dijalankan dalam reaktor tertutup selama 12 hari. Hasil proses kemudian diukur parameter warna, COD dan alkalinitasnya.Hasil penelitian pengolahan air limbah batik secara kimia dapat menurunkan parameter warna yang berasal dari zat warna Naphtol sebesar 83,15 %, COD sebesar 28,82% dan pH hasil proses 7. Proses biologi anaerob menurunkan parameter warna sebesar 94,95%, COD sebesar 59,89% dan pH hasil proses 5. Proses biologi aerob dapat menurunkan parameter warna yang berasal dari zat warna Naphtol sebesar 97,82%, COD sebesar 72, 88% dan pH hasil proses 6,5. Sehingga dapat disimpulkan bahwa pengolahan limbah cair batik secara biologi aerob lebih efektif daripada pengolahan secara biologi anaerob maupaun secara kimia. Kata kunci : pengolahan air limbah batik, proses kimia, proses biologi

IMPLEMENTASI SUBVERSION DAN REDMINE PROJECT MANAGEMENT DALAM PERANCANGAN TOKO KUE ONLINE

Directory of Open Access Journals (Sweden)

Xanty Adhi Parandani

2016-04-01

Full Text Available Belanja online telah menjadi gaya hidup konsumen saat ini. Kemudahan, mobilitas dan fleksibilitas menjadi daya tarik dari komponen e-commerce ini. Bagi penjual, metode penjualan via web merupakan salah satu metode yang sangat efisien, ekonomis dan efektif untuk meningkatkan omzet penjualan. Sebagai contoh kasus untuk penerapan konsep manajemen proyek, dibuat sebuahpurwarupa toko kue yang dirancang untuk sistem penjualan berbasis web (online. Purwarupa ini dibangun secara tim, dimana komponen dari situs ini dibuat secara terpisah- pisah oleh masing-masing anggota tim. Dengan memanfaatkan fasilitas Subversion, partisi komponen sistem disatukan menjadi sebuah sistem yang utuh. Sebagai sebuah proyek sistem informasi yang dibangun secara tim, dibuat sistem pengaturan proyek menggunakan sebuah aplikasi manajemen proyek, Redmine Project Management. Redmine merupakan proyek manajemen berbasis web yang dibangun dengan bahasa Ruby diatas Framework Rail. Pembangunan web secara berkelompok dengan tugas individu mandiri akan sangat bermanfaat dalam mengembangkan kreativitas setiap individu, sehingga situs yang dihasilkan akan lebih unik, menarik dan easy fault tracing, karena mudahnya melacak letak dan penyebab kesalahan. Dari hasil kolaborasi menggunakan fasilitas Redmine dan Subversion, diperoleh sebuah situs toko kue online yang merupakan represntasi dari beragam gagasan anggota tim, namun bisa diintegrasikan dan berfungsi dengan baik, selayaknya situs yang dibuat secara individu. Kata kunci: e-commerce, Tokokueku, Subversion, Redmine project management, ruby, framework rail.

PENGARUH INTERNET DALAM PENGEMBANGAN BAHASA DAN BUDAYA DI KALANGAN REMAJA KOTA PADANG

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Lilimiwirdi Lilimiwirdi

2016-10-01

Full Text Available Penggunaan internet di kalangan remaja berpengaruh terhadap bahasa dan budayanya. Dia menggunakan internet untuk berbagai ranah kehidupan. Metode yang digunakan adalah metode simak. Pengambilan data dilakukan dengan penyimakan data bahasa yang dituturkan oleh remaja dan disesuaikan dengan data yang ditampilkan oleh internet. Hasilnya, yaitu banyaknya kosakata di bidang komputer dalam bahasa Inggris yang masuk ke dalam bahasa Indonesia, baik dalam bentuk pemungutan, penyesuaian atau adaptasi, dan pengambilan secara lansung atau adopsi. Bahkan, remaja ini lebih kenal istilah dalam bahasa Inggris daripada bahasa Indonesia karena istilah dalam bidang komputer dan internet yang mereka gunakan masih dalam bahasa Inggris. Melalui internet, juga terbangun kemampuan berbahasa Indonesia dengan baik karena meningkatnya budaya menulis atau mengetik, membaca, bercerita, dan mengekspos diri. Dengan adanya peningkatan budaya tadi, lahirlah bahasa-bahasa gaul di kalangan netizen atau remaja. Keberadaan internet ini juga membangun budaya, baik positif maupun negatif. Budaya positifnya adalah menulis atau mengetik, membaca, mencari informasi dengan secara cepat, belajar secara online, berkirim surat secara online, tes online, adanya situs pemerintahan secara online, berbelanja online, toko online, budaya pertemanan, mengekspos diri, dan sebagainya. Kemudian, ada juga budaya negatif, seperti budaya kriminal, menimbulkan kecanduan ketika bermain game, membuka video porno, membuka facebook orang, mengurangi produktivitas, merusak otak, sulit tidur, kurangnya berinteraksi dengan lingkungan, dan sebagainya.

Komunikasi Getok Tular Pengantar Popularitas Merek

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Rudy Harjanto

2008-12-01

Full Text Available Komunikasi getok tular (Word of mouth-WOM adalah komunikasi berantai yang beredar dengan sendirinya di suatu komunitas tertentu, merujuk pada penyampaian informasi yang pada umumnya dilakukan secara lisan, informal dari seseorang kepada orang lain secara pribadi, antara dua individu atau lebih. Perkembangan teknologi memungkinkan komunikasi getok tular juga berkembang melalui internet, situs web, maupun halaman-halaman profil online, posting dalam blog-blog pribadi maupun pertukaran informasi melalui e-mail. Mereka memperkaya isi percakapan dengan informasi pandangan, pengetahuan, dan sebagainya, secara terus-menerus. Komunikasi getok tular tumbuh subur dalam masyarakat kolektivis, seperti di Indonesia, karena dalam masyarakat kolektivis, diri (self tidak bersifat unik atau otonom, melainkan lebur dalam kelompok (keluarga, klan, kelompok kerja, sukubangsa, bangsa, dsb. Secara tradisional, komunikasi getok tular terjadi pada saat orang-orang sangat berminat pada topik yang diperbincangkan. Komunikasi getok tular dapat dikembangkan sebagai saluran referensi untuk mempopularkan merek (produk, karena khalayak sasaran lebih percaya pada pesan yang disampaikan oleh orang yang mereka kenal, dan mereka hargai.

Perilaku Bullying dan Peranan Guru BK/Konselor dalam Pengentasannya (Studi Deskriptif terhadap Siswa SMP Negeri 3 Lubuk Basung

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Ilfajri Yenes

2016-06-01

Full Text Available Bullying merupakan suatu situasi di mana terjadinya penyalahgunaan kekuatan/kekuasaan yang dilakukan oleh seseorang/kelompok. Perilaku bullying merupakan  salah satu bentuk kekerasan dan agresif siswa di sekolah. Penelitian ini adalah penelitian deskriptif yang bertujuan untuk mendeskripsikan perilaku bullying yang ditampilkan siswa SMPN 3 Lubuk Basung dan peranan guru BK/konselor dalam pengentasannya. Populasi penelitian adalah siswa di SMP Negeri 3 Lubuk Basung berjumlah  564 orang dengan sampel 138 orang diambil dengan menggunakan teknik propotonal stratified random. Teknik pengumpulan data dengan menggunakan angket. Temuan penelitian menunjukkan bahwa jenis perilaku bullying yang dominan terjadi yaitu menyakiti secara verbal dilanjutkan dengan menyakiti secara fisik kemudian menyakiti secara mental dengan faktor keluarga. Faktor teman sebaya merupakan faktor yang lebih dominan sebagai penyebab perilaku bullying siswa. Secara umum guru BK/konselor cukup berperan mengatasi perilaku bullyingdengan memberikan  layanan informasi sebagai layanan yang lebih dominan diberikan dilanjutkan dengan layanan bimbingan kelompok dan konseling kelompok serta pemberian layanan konseling individual.

PENGGUNAAN BIOCATALYS ELECTROLYSIS DALAM PENURUNAN KONSENTRASI TOTAL SUSPENDED SOLID (TSS DAN CHEMICAL OXYGEN DEMAND (COD LIMBAH DOMESTIK

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Wiharyanto Oktiawan

2016-09-01

Full Text Available Secara umum air limbah kegiatan rumah tangga (domestik dibuang langsung menuju badan air seperti sungai dan danau. Pengolahan limbah cair secara biologis (aerob sering menghasilkan lumpur dalam jumlah besar. Jumlah lumpur dapat dikurangi dengan pengolahan anaerob. Sistem bioelektrokimia merupakan salah satu terobosan teknologi yang memungkinkan untuk mengolah limbah sekaligus menghasilkan energi berupa gas metana. Penggunaan biocatalys electrolysis dapat mengatasi kelemahan proses anaerob secara konvensional dalam penurunan konsentrasi TSS dan COD limbah domestik salah satunya mampu menghasilkan gas H2 dari proses elektrolisis. Penambahan daya ekternal sebesar 6 volt mampu menyisihkan TSS sampai kadar 82 mg/l dari kadar semula 157 mg/l. Tegangan 12 volt mampu menurunkan kadar COD sampai 47,46 mg/l dari kadar awal 223 mg/l. Penyisihan TSS paling rendah pada waktu elektrolisis 15 menit dengan kadar 87 mg/l. Penambahan waktu elektrolisis sebanding dengan penurunan konsentrasi COD limbah domestik. Pada penelitian ini kualitas maupun kuantitas gas metana tidak diketahui secara jelas. Selain gas metan, produk fermentasi juga belum diketahui.

Analisis SWOT Implementasi Tekonologi Finansial terhadap Kualitas Layanan Perbankan di Indonesia

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Imanuel Adhitya Wulanata Chrismastianto

2017-04-01

Menyikapi realisasi era digital saat ini, kualitas layanan perbankan di Indonesia diharapkan semakin meningkat secara signifikan, agar mampu menjangkau seluruh lapisan masyarakat, khususnya bagi masyarakat yang tinggal di daerah 3T (Terdepan, Terluar, dan Terpencil. Namun, pada kenyataannya kualitas layanan perbankan di Indonesia saat ini masih minim dalam mengakses masyarakat yang tinggal di daerah 3T tersebut. Mencermati berbagai realita yang telah diuraikan di atas, maka melalui analisis SWOT implementasi kebijakan teknologi finansial ini, diharapkan kualitas layanan perbankan semakin dapat ditingkatkan dan dirasakan oleh seluruh lapisan masyarakat Indonesia secara riil dan para pelaku perbankan dapat memahami pengelolaan fungsi manajemen perbankan dengan tepat didasarkan pada sikap takut akan Tuhan dan menghargai sesama, dalam konteks pengelolaan aset internal maupun eksternal yang mencakup aktivitas perbankan secara holistik. Dengan demikian, tulisan ini bertujuan untuk menganalisis secara lebih mendalam mengenai kekuatan, kelemahan, peluang, dan ancaman (SWOT implementasi teknologi finansial terhadap kualitas layanan perbankan Indonesia di era digital melalui studi literatur perbankan.

PENGARUH KUALITAS PELAYANAN TERHADAP KEPUASAN SISWA SEBAGAI NASABAH PADA BANK MINI SMK SMART AKUNTANSI DI SMK NEGERI 3 JEPARA

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Eka Sartika

2016-03-01

Full Text Available Penelitian ini dilakukan untuk mengetahui pengaruh kualitas pelayanan terhadap kepuasan siswa sebagai nasabah Bank Mini SMK Smart Akuntansi di SMK Negeri 3 Jepara secara simultan mapun parsial . Populasi dalam penelitian ini adalah seluruh siswa kelas X - XI tahun 2012/2013 SMK Negeri 3 Jepara yang terdaftar sebagai nasabah per 31 Desember 2012 sebanyak 157 siswa . Pengambilan sampel dilakukan se cara undian dengan metode proportional random sampling, dengan jumlah responden sebanyak 112 siswa. Metode pengambilan data menggunakan angket. Metode analisis data menggunakan analisis deskriptif dan analisis regresi linier berganda. Berdasarkan hasil pen elitian, kualitas pelayanan berpengaruh terhadap kepuasan siswa sebagai nasabah secara simultan . Secara parsial, v ariabel bukti fisik (tangible berpengaruh terhadap kepuasan siswa sebagai nasabah sebesar 4,0%, variabel jaminan ( assurance berpengaruh terhadap kepuasan siswa sebagai nasabah sebesar 6,15% dan empati ( emphaty berpengaruh terhadap kepuasan siswa sebagai nasabah sebesar 11,29%. Sedangkan variabel keandalan dan daya tangkap tidak berpengaruh secara parsial terhadap kepuasan siwa sebagai nasabah Bank Mini Smart Akuntansi

PENGEMBANGAN PLATFORM KOMUNIKASI INSTANT UNTUK MENDUKUNG COLABORATIVE LEARNING PADA UNIVERSITAS DIAN NUSWANTORO

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Fahri Firdausillah

2015-10-01

Full Text Available Instant messaging (IM atau chatting merupakan aplikasi internet yang memungkinkan penggunanya saling berkomunikasi melalui pesan teks, audio, maupun video secara langsung. Keunggulan IM yang memungkinkan pengguna berinteraksi secara langsung berpotensi untuk diterapkan dalam pengembangan sebuah metode pembelajaran kolaboratif di Universitas Dian Nuswantoro (UDINUS. Sistem informasi akademik (SiAdin merupakan aplikasi berbasis web yang membantu manajemen administratif dan edukatif pada UDINUS yang memungkinkan mahasiswa, dosen maupun staff yang lain untuk saling bertukar informasi serta kebutuhan akademik. Namun, hingga kini, SiAdin masih belum terintegrasi dengan platform komunikasi instan apapun.Meskipun layanan broadcast pesan telah diterapkan, namun pengguna harus membuat group secara manual, kemudian menambahkan anggota group secara manual terlebih dahulu. Hal ini menjadikan proses komunikasi kolaboratif jadi kurang optimal.Dalam penelitian ini, penulis mengusulkan menerapkan metode Computer-supported collaborative learning (CSCL di UDINUS dengan memanfaatkan SiAdin yang telah berjalan di UDINUS untuk mendukung berjalannya collaborative learning. Kata Kunci: Instant Messaging, SiAdin, Pembelajaran Kolaboratif.

Apnéia na sala de recuperação pós-anestésica: relato de caso Apnea en la sala de recuperación pós-anestésica: relato de caso Apnea in the postanesthetic recovery room: case report

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Joel Massari Rezende

2003-06-01

Full Text Available JUSTIFICATIVA E OBJETIVOS: A depressão respiratória é uma complicação que pode ocorrer no pós-operatório quando se utilizam opióides na anestesia. O objetivo deste relato é discutir um caso de apnéia em paciente que chegou consciente à sala de recuperação pós-anestésica (SRPA, após ter sido submetido à tireoidectomia sob anestesia geral com propofol, fentanil e isoflurano. RELATO DO CASO: Paciente do sexo feminino, 50 anos, 60 kg, estado físico ASA I, submetida à tireoidectomia sob anestesia geral induzida com propofol (140 mg, fentanil (350 µg, atracúrio (30 mg e mantida com isoflurano, duas doses subseqüentes em bolus de atracúrio (10 mg cada e ventilação controlada mecânica. No final da cirurgia, após antagonização do bloqueio neuromuscular, a paciente foi extubada, obedeceu aos comandos para respirar e colaborou na passagem à maca, sendo transportada para a SRPA, aonde chegou consciente. Minutos após, apresentou apnéia, cianose e inconsciência. Foi realizada ventilação manual com oxigênio a 100% seguida de injeção de naloxona (0,2 mg por via venosa, havendo retorno da ventilação espontânea e da consciência. CONCLUSÕES: Os cuidados ventilatórios no pós-operatório, durante o transporte, admissão à SRPA e permanência nessa unidade, devem ser contínuos em pacientes que receberam opióides, mesmo demonstrando estar conscientes ao deixarem a sala cirúrgica.JUSTIFICATIVA Y OBJETIVOS: La depresión respiratoria es una complicación que puede ocurrir en el pós-operatorio cuando se utilizan opioides en la anestesia. El objetivo de este relato es discutir un caso de apnea en paciente que llegó consciente a la sala de recuperación pós-anestésica (SRPA, después de haber sido sometido a tireoidectomia sobre anestesia general con propofol, fentanil e isoflurano. RELATO DE CASO: Paciente del sexo femenino, 50 años, 60 kg, estado físico ASA I, sometida a la tireoidectomia sobre anestesia general

Bayesian network model for identification of pathways by integrating protein interaction with genetic interaction data.

Science.gov (United States)

Fu, Changhe; Deng, Su; Jin, Guangxu; Wang, Xinxin; Yu, Zu-Guo

2017-09-21

Molecular interaction data at proteomic and genetic levels provide physical and functional insights into a molecular biosystem and are helpful for the construction of pathway structures complementarily. Despite advances in inferring biological pathways using genetic interaction data, there still exists weakness in developed models, such as, activity pathway networks (APN), when integrating the data from proteomic and genetic levels. It is necessary to develop new methods to infer pathway structure by both of interaction data. We utilized probabilistic graphical model to develop a new method that integrates genetic interaction and protein interaction data and infers exquisitely detailed pathway structure. We modeled the pathway network as Bayesian network and applied this model to infer pathways for the coherent subsets of the global genetic interaction profiles, and the available data set of endoplasmic reticulum genes. The protein interaction data were derived from the BioGRID database. Our method can accurately reconstruct known cellular pathway structures, including SWR complex, ER-Associated Degradation (ERAD) pathway, N-Glycan biosynthesis pathway, Elongator complex, Retromer complex, and Urmylation pathway. By comparing N-Glycan biosynthesis pathway and Urmylation pathway identified from our approach with that from APN, we found that our method is able to overcome its weakness (certain edges are inexplicable). According to underlying protein interaction network, we defined a simple scoring function that only adopts genetic interaction information to avoid the balance difficulty in the APN. Using the effective stochastic simulation algorithm, the performance of our proposed method is significantly high. We developed a new method based on Bayesian network to infer detailed pathway structures from interaction data at proteomic and genetic levels. The results indicate that the developed method performs better in predicting signaling pathways than previously

Ofloxacin: new applications for the prevention of urinary tract infections in renal graft recipients.

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Rafat, C; Vimont, S; Ancel, P Y; Xu-Dubois, Y C; Mesnard, L; Ouali, N; Denis, M; Vandewalle, A; Rondeau, E; Hertig, A

2011-08-01

Urinary tract infections (UTIs), the most common form of bacterial infection in kidney transplant recipients, recently have been demonstrated to be detrimental for long-term graft outcome. Therefore, reinforcing antibiotic prophylaxis might be vital, in addition to basic hygiene recommendations, surgical care, and prophylaxis by trimethoprim-sulfamethoxazole. In 2006, a Legionella pneumophila contamination of our department's water pipes meant that all the patients undergoing renal transplantation underwent a 1-month regimen of ofloxacin (OFLO) (200 mg every other day). We took this opportunity to measure the incidence of UTI, including acute pyelonephritis (APN), in 100 consecutive patients transplanted before (n = 50) and after (n = 50) this treatment decision was reached. We also studied the antimicrobial resistance profiles in our department and in the rest of the hospital. No patient developed Legionnaire's disease. A dramatic decrease in the incidence of UTI (-63%) was also seen in patients undergoing OFLO treatment. Logistic regression analysis demonstrated that the use of OFLO was independently associated with a reduction in UTI (odd ratio [OR] = 0.31%, 95% confidence interval [CI] 0.11-0.84, P = 0.02) and APN (OR = 0.21%, 95% CI 0.07-0.98, P = 0.045). This protection was sustained during the whole first year post transplantation. As for resistance rates, we observed a decrease in the susceptibility of Pseudomonas aeruginosa to ciprofloxacin in our nephrology department, compared with that observed in the rest of the hospital. The incidence of multi-resistant bacteria was stable. Our unintentional extension of prophylactic antibiotherapy with OFLO gave rise to a dramatic decrease in the 1-year incidence of UTI and APN in kidney recipients. Emergence of resistant strains is, however, a major concern. © 2011 John Wiley & Sons A/S.

The ontogeny of nutrient transporter and digestive enzyme gene expression in domestic pigeon (Columba livia) intestine and yolk sac membrane during pre- and posthatch development.

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Dong, X Y; Wang, Y M; Yuan, C; Zou, X T

2012-08-01

To better understand the digestive capacity in domestic pigeons (Columba livia), this study was conducted to evaluate nutrient transporters and digestive enzymes gene expression in small intestine and yolk sac membrane (YSM) during pre- and posthatch development. We investigated the oligopeptide transporter Pept1, sodium glucose transporter SGLT1, glucose transporter GLUT2, aminopeptidase-N (APN), and sucrase-isomaltase (SI). Intestine was collected at embryo d 12, 14, and 16, day of hatch, and d 1, 3, 5, 8, and 14 posthatch. The YSM was collected at embryo d 12, 14, 16, and day of hatch. The cDNA fragments for Pept1, SGLT1, GLUT2, APN, and SI were isolated and cloned using reverse-transcription PCR. The sequences data showed that these genes were highly identical to the gene of chicken. The mRNA expression of each gene was assayed using real-time PCR. Expression of intestinal nutrient transporters increased linearly (Ppigeons and establish a foundation for future research on the nutrients requirements for young pigeons.

The position and authority of the Aceh Shari'a court on the Indonesian justice system

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- Sufiarina

2015-07-01

Full Text Available Pasal 27 ayat (1 Undang-Undang No. 48 Tahun 2009 tentang Kekuasaan Kehakiman menyatakan; “Pengadilan khusus hanya dapat dibentuk dalam salah satu lingkungan peradilan yang berada di bawah Mahkamah Agung”. Lingkungan badan peradilan di bawah Mahkamah Agung meliputi peradilan umum, peradilan agama, peradilan militer dan peradilan tata usaha negara. Pasal 3A ayat (2 Undang-Undang No. 50 Tahun 2009 tentang Perubahan Kedua atas Undang-Undang Peradilan Agama, menempatkan Mahkamah Syari’ah sebagai pengadilan khusus dalam lingkungan peradilan agama dan sebagai pengadilan khusus dalam lingkungan peradilan umum. Penempatan Mahkamah Syari’ah sebagai pengadilan khusus, sekaligus di dua lingkungan peradilan inkonsistensi dengan Pasal 27 ayat (1 Undang-Undang Kekuasaan Kehakiman. Secara substansi Undang-Undang Peradilan Agama pada hakikatnya merupakan pelaksanaan dari undang-undang Kekuasaan Kehakiman. Inkonsistensi ini menimbulkan permasalahan hukum yang perlu dicarikan penyelesaiannya secara yuridis. Permasalahan mengenai inkonsistensi aturan hukum tersebut dikaji secara yuridis normatif dengan spesifikasi penelitian deskriptif analisis. Teknik pengumpulan data melalui studi kepustakaan dan didukung data lapangan, dan dianalisis secara yuridis kualitatif. Kajian ini menemukan bahwa Mahkamah Syariah sesungguhnya bukanlah dalam spesifikasi pengadilan khusus dan juga tidak berpijak pada dua lingkungan peradilan. Secara administrasi umum maupun pengelolaan perkara Mahkamah Syari’ah merupakan Pengadilan Agama untuk wilayah Propinsi NAD yang kewenangannya diperluas dalam rangka melaksanakan otonomi khusus bidang pelaksanaan syariat Islam.

Pemetaan Risiko Tsunami terhadap Bangunan secara Kuantitatif

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Totok Wahyu Wibowo

2017-12-01

Full Text Available ABSTRAK Tsunami merupakan bencana alam yang sebagian besar kejadiannya dipicu oleh gempabumi dasar laut. Dampak kerugian tsunami terhadap lingkungan pesisir antara lain rusaknya properti, struktur bangunan, infrastruktur dan dapat mengakibatkan gangguan ekonomi. Bencana tsunami memiliki keunikan dibandingkan bencana lainnya, karena memiliki kemungkinan sangat kecil tetapi dengan ancaman yang tinggi. Paradigma Pengurangan Risiko Bencana (PRB yang berkembang dalam beberapa tahun terakhir yang menekankan bahwa risiko merupakan hal utama dalam penentuan strategi terhadap bencana. Kelurahan Ploso, merupakan salah satu lokasi di Kabupaten Pacitan yang berpotensi terkena bencana tsunami. Pemetaan risiko bangunan dilakukan dengan metode kuantitatif, yang mana disusun atas peta kerentanan dan peta harga bangunan. Papathoma Tsunami Vulnerability 3 (PTVA-3 diadopsi untuk pemetaan kerentanan. Data harga bangunan diperoleh dari kombinasi kerja lapangan dan analisis Sistem Informasi Geografis (SIG. Hasil pemetaan risiko menunjukkan bahwa Lingkungan Barehan memiliki risiko kerugian paling tinggi diantara semua lingkungan di Kelurahan Ploso. Hasil ini dapat dijadikan sebagai acuan untuk penentuan strategi pengurangan risiko bencana di Kelurahan Ploso. ABSTRACT Tsunami is a natural disaster whose occurrences are mostly triggered by submarine earthquakes. The impact of tsunami on coastal environment includes damages to properties, building structures, and infrastructures as well as economic disruptions. Compared to other disasters, tsunamis are deemed unique because they have a very small occurrence probability but with a very high threat. The paradigm of Disaster Risk Reduction (DRR that has developed in the last few years stresses risk as the primary factor to determine disaster strategies. Ploso Sub-district, an area in Pacitan Regency, is potentially affected by tsunamis. The risk mapping of the buildings in this sub-district was created using a quantitative method based on maps of vulnerability and building’s cost. This research used Papathoma Tsunami Vulnerability 3 (PTVA-3 for vulnerability mapping. The cost of the buildings was obtained from a combination of fieldwork and Geographic Information System (GIS. The results of risk mapping showed that the Barehan Environment had the highest risk of loss among the other environments in Ploso Sub-district. These findings, thereby, can be used as a reference for determining DRR strategy in Ploso Sub-district.

BELAJAR BAHASA SECARA HOLISTIK: APAKAH PANDANGAN MURID ?

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Zulkifli Osman

2013-10-01

  Learning Language by Holistic Approach: What Atudent’s View”. A variety of teaching approaches such as structural approach, code-cognitive, communicative was implemented in the classroom. These approaches have their own specific strength and weakness. The cod-cognitive approach emphasizes on the ability of the students to mastering the language competence. The communicative approach likewise to enhance on the communication process only. The purpose of this study is to introduce the implementation of the holistic approach in teaching of the Malay Language to ensure pupils are able to learn the language as a whole or holistic. In order to obtain the student’s views on the implementation of this approach, questionnaire and semi-structured interview was implemented. Document analysis also used in order to support the data. One hundred and twenty five students are involved in this study whose consist of three classes of Form Four (SMA. Questionnaires and interviews were administered to the students after teaching modules run. Results showed that the language process by using the holistic approach is more attractive. This approach is able to increase the student’s motivation and language skills. Implications of the study are also discussed Keywords: Learning language, language learning, holistic approach,                   language teaching modules

Pengolahan Limbah Cair Rumah Sakit secara Sonochemical

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Laila Kusuma

2017-06-01

Full Text Available Hospital as a service provider has an important role in human life, especially for people who are experiencing physical and mental disorders. Various types of diseases and therapies performed in hospitals has made it as one of the producers of hazardous and infectious waste that requires special handling and processing so as not to pollute the water, soil, and air environment. Hospital wastewater treatment was conducted to determine the ability of sonochemical method to reduce level of Chemical Oxygen Demand (COD and determine the optimum conditions of the parameters used by the design of Response Surface Methodology Box-Behnken. The parameters that affected this process was the concentration of hydrogen peroxide (H2O2, pH, and reaction time. The Waste used was taken from the waste water treatment plant in Zainoel Abidin General Hospital in Banda Aceh with COD value 260.65 ppm. The optimum conditions of this treatment process occured at pH 2, H2O2 concentration 500 ppm, and reaction time 119.98 minutes with reduction of COD was 81.88%.ABSTRAKRumah sakit sebagai penyedia layanan jasa memegang peranan cukup penting dalam kehidupan manusia, terutama bagi orang-orang yang sedang mengalami gangguan fisik dan mental. Berbagai jenis penyakit dan terapi yang dilakukan di rumah sakit telah menjadikannya sebagai salah satu penghasil limbah berbahaya dan infeksius yang memerlukan penanganan dan pengolahan khusus agar tidak mencemari lingkungan yaitu air, tanah dan udara. Pengolahan limbah cair rumah sakit dilakukan untuk mengetahui kemampuan metode sonochemical dalam menurunkan kadar Chemical Oxygen Demand (COD dan menentukan kondisi optimum dari parameter yang digunakan berdasarkan disain Response Surface Methodology Box-Behnken. Parameter yang mempengaruhi proses ini adalah konsentrasi hidrogen peroksida (H2O2, pH, dan waktu reaksi. Limbah yang digunakan diambil dari instalasi pengolahan air limbah di Rumah Sakit Umum Zainoel Abidin Kota Banda Aceh dengan nilai COD sebesar 260,65 ppm. Kondisi optimum dari proses pengolahan terjadi pada pH 2, konsentrasi H2O2 500 ppm, dan waktu reaksi 119,98 menit dengan penurunan COD sebesar 81,88 %

Pembelajaran Interdisipliner: Upaya Mengapresiasi Sastra Secara Holistik

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Daru Kabeka Janarto

2010-10-01

Full Text Available The research is regarding 4 class cycle about interdisciplinary teaching technique of literature teaching in BINUS International School Simprug, Jakarta. The interdisplinary teaching is done in grade 10 in 3 subjects of Indonesian Language and Literature, Computer (IT, and Visual Arts. The teaching topic is Ma Yan, a novel about Muslim teenager who struggles for education in Zhang Jiashu, a remote village in China. This teaching climax is talk show with the writer of Ma Yan and its publisher followed with visual arts show from the students. The observation result shows that talent and involvement of students are high through the learning materials, proved by assignments done in time and their antusiasm towards their projects and assignments.  

Keterampilan Mendengarkan Secara Aktif dalam Komunikasi Interpersonal

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Nikodemus Thomas Martoredjo

2014-04-01

Full Text Available Interpersonal communication is transactional and two-way direction. Therefore active listening skills play a key role in interpersonal communication. These active listening skills can have a positive impact on communication and at the same time creating a better relationship. So it is very useful to improve the skills of active listening. This paper intends to reveal the important role of active listening skills in interpersonal communication, identifying the challenges that exist within it both internally and externally as well as indicate the action that needs to be developed to improve these skills. 

MONITORING TETESAN INFUS BERBASIS MIKROKONTROLER ATMEGA16

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Ardiyanto Iqbal Nugroho

2015-09-01

Penelitian ini menghasilkan suatu alat monitoring tetesan infus yang dapat memberikan informasi mengenai laju kecepatan tetesan dan kondisi cairan pada infus. Sistem yang secara realtime dimonitoring oleh perawat ini dapat mengurangi permasalahan yang timbul karena kelalaian petugas. Sehingga perawat tidak secara manual dalam mengatur kecepatan tetesan infus dan meningkatkan pelayanan kepada pasien.

PENYULUHAN TEPAT GUNA YANG BERKAITAN DENGAN PENYAKIT MALARIA BAGI PENDUDUK HARGOTIRTO KECAMATAN KOKAP, KABUPATEN KULONPROGO, DI YOGYAKARTA

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Siti Sapardiyah Santoso

2012-10-01

Full Text Available Penelitian "Penyuluhan yang Tepat Guna bagi Masyarakat Daerah Endemis Malaria di Kecamatan Kokap, Kabupaten Kulonprogo, Daerah Istimewa Yogyakarta" dilakukan untuk mendapatkan gambaran karakteristik kelompok sasaran, tentang pengetahuan, sikap, dan perilaku kelompok sasaran sebelum dan sesudah intervensi. dan mendapatkan penyuluhan yang tepat guna untuk masyarakat kelompok sasaran. Metode pengumpulan data dilakukan pada awal sebelum dilakukan intervensi dan pada akhir setelah dilakukan intervensi. lntervensi dilakukan dengan cara tatap muka, diskusi, dan alat bantu media penyuluhan sebanyak tiga kali. Subyek penelitian adalah ibu, bapak, tokoh masyarakat (Toma, dan remaja yang dipilih berdasarkan cara sampling acak sederhana. Pengumpulan data dilakukan dengan cara menggunakan kuesioner. Hal ini dilakukan untuk menggali informasi pengetahuan, sikap, dan perilaku secara kuantitatif. Dan, diskusi kelompok terarah (DKT menggali informasi pengetahuan, sikap dan perilaku, termasuk keyakinan, dan harapan masyarakat secara kualitatif. Hasil penelitian menunjukkan peningkatan perubahan pengetahuan, sikap, dan perilaku secara bermakna pada kelompok intervensi. Peningkatan persentase pada kelompok sasaran berkisar, antara 10% sampai 80%. Sedang pada daerah kontrol hanya sekitar 5% sampai 40%, terutama pengetahuan tentang nyamuk malaria. Peningkatan yang terjadi pada kelompok kontrol kemungkinan karena adanya difusi dari daerah intervensi atau program rutin yang dilakukan oleh Dinas Kesehatan. Penyuluhan yang dilakukan dengan tatap muka, diskusi dengan alat bantu media tentang malaria dapat dilakukan secara mudah dan praktis, dibandingkan dengan menggunakan film atau video, serta dapat dilakukan secara interpersonal maupun kelompok. Guna penerapan di daerah lain diperlukan tenaga yang secara teratur melakukan tatap muka dan diskusi dengan kelompok masyarakat. Penyuluhan tersebut harus terintegrasi dengan strategi advokasi, bina suasana dan gerakan (ABG

Perilaku Masyarakat Kabupaten Belitung Terhadap Layanan Isi Ulang Pulsa Telepon Seluler Elektronik

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Kasmad Ariansyah

2012-12-01

Full Text Available Telepon seluler prabayar merupakan telepon seluler yang pembayaran pulsanya dilakukan diawal dengan membeli voucher pulsa dengan nominal tertentu. Pada awalnya pulsa telepon seluler prabayar hanya dijual dalam bentuk kartu berbahan kertas dengan kode-kode tertentu diatasnya.  Sekarang kita sudah menemui layanan isi ulang pulsa secara elektronik. Penggunaan voucher telepon berbentuk fisik yang berbahan kertas, tidak sejalan dengan program pemerintah yang sedang menggalakkan paperless. Terlebih Jumlah pelanggan seluler di Indonesia yang demikian besar, pada awal 2012 ATSI mencatat  sekitar 240 juta orang Indonesia menggunakan layanan seluler dan sebagian besarnya adalah pelanggan prabayar. Penelitian ini bertujuan mendapatkan gambaran perilaku dan konstruk-konstruk yang mempengaruhi masyarakat Kabupaten Belitung terhadap layanan isi ulang pulsa telepon seluler secara elektronik dan diharapkan dapat menjadi salah satu masukan bagi penyusunan strategi meningkatkan adopsi layanan isi ulang secara elektronik. Temuan dari penelitian ini adalah konstruk perceived of usefullness dan personal innovativeness secara positif dan signifikan mempengaruhi minat berperilaku dalam menggunakan voucher elektronik pada masyarakat di Kabupaten Belitung. Sedangkan dua konstruk lainnya yaitu social influence dan perceived cost pengaruhnya tidak signifikan.

Pengembangan E-Lecture menggunakan Web Service Sikadu untuk Mendukung Perkuliahan di Universitas Negeri Semarang

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Anggyi Trisnawan Putra

2015-10-01

Full Text Available Proses penjadwalan di Universitas Negeri Semarang yang sedemikian rumit menghasilkan data penjadwalan yang tersimpan di dalam database Sikadu (Sistem Informasi Akademik Terpadu berupa keterkaitan antara data dosen, mahasiswa, dan mata kuliah. Namun, data ini tidak diintegrasikan secara langsung ke dalam aplikasi/sistem e-learning yang disediakan oleh Unnes, mengakibatkan adanya proses/kegiatan yang tidak perlu sebelum dapat menggunakan aplikasi e-learning. Dengan fakta bahwa data penjadwalan dapat diakses secara online, dapat dirancang aplikasi pendukung e-lecture dengan memanfaatkan data tersebut. Pertama-tama, dirancang web service yang akan menyajikan akses aman ke dalam data Sikadu. Lalu, dirancang database e-lecture yang akan memanfaatkan web service yang telah dibuat tersebut. Data akan disajikan dalam interface yang dibuat dengan HTML, bermesin PHP. Dosen dan mahasiswa dapat menggunakan akses login yang sama dengan Sikadu untuk dapat langsung memanfaatkan aplikasi ini. Dengan adanya aplikasi ini, proses perkuliahan meliputi sharing bahan ajar, pemberian tugas/aktivitas kuliah, integrasi pengumpulan tugas, koreksi nilai tugas, pembatasan waktu pengumpulan tugas secara tegas (tersistem dan lain sebagainya dapat dilakukan secara mudah dan efisien. 

PENGARUH TERPAAN INFORMASI RISET MELALUI WEBSITE www.ppet.lipi.go.id TERHADAP SIKAP MAHASISWA MENGENAI PENELITIAN

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Noorfiya Umniyati

2017-06-01

Full Text Available Penelitian ini bertujuan untuk mengukur pengaruh terpaan informasi riset di Pusat Penelitian Elektronika dan Telekomunikasi LIPI melalui website www.ppet.lipi.go.id terhadap sikap mahasiswa mengenai penelitian. Tujuan penelitian ini untuk mengetahui besarnya pengaruh jumlah waktu yang digunakan dalam mengakses informasi terhadap sikap mahasiswa mengenai penelitian, isi pesan terhadap sikap mahasiswa mengenai penelitian, dan hubungan individu dengan media terhadap sikap mahasiswa mengenai penelitian. Penelitian ini menggunakan metode kuantitatif dengan analisis jalur. Hasil penelitian ini menunjukan bahwa secara keseluruhan terpaan informasi riset melalui website www.ppet.lipi.go.id berpengaruh secara signifikan terhadap sikap mahasiswa Teknik Telekomunikasi Telkom University mengenai penelitian. Secara parsial, hasil penelitian menunjukkan bahwa variabel jumlah waktu yang digunakan dalam informasi dan variabel hubungan individu dengan media memberikan pengaruh yang siginifikan terhadap sikap mahasiswa mengenai penelitian. Sedangkan variabel isi pesan tidak memberikan pengaruh yang siginifikan karena memberikan pengaruh yang sedikit. Kesimpulan pada penelitian ini menunjukan bahwa secara keseluruhan informasi riset telah melakukan terpaan cukup besar terhadap sikap mahasiswa jurusan Teknik Telekomunikasi Telkom University mengenai penelitian yang mengakses website www.ppet.lipi.go.id.

SISTEM INFORMASI PENJUALAN PRODUK BERBASIS WEB PADA CHANEL DISTRO PRINGSEWU

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Wulandari Wulandari

2017-05-01

Full Text Available Chanel Distro Pringsewu adalah sebuah toko yang menjual kaos, jaket,  kemeja, sweeter, kaos kerah dll yang berada di pusat perbelanjaan pringsewu. Sistem penjualan, pemasaran dan promosi yang dipakai saat ini masih menggunakan sistem secara manual. Sangat perlu adanya kemudahan pelayanan untuk memudahkan pelanggan yang jauh dari jangakauan. Untuk itu dirancang sistem penjualan online pada Chanel Distro Pringsewu berbasis web dengan bahasa pemrograman PHP dan MySQL secara online yang dikenal dengan istilah E-Commerce (Elektronic commerce .Aplikasi ini mempermudah pelanggan membeli produk Chanel Distro Pringsewu secara online kapan saja dan dimana saja tanpa menyita waktu,dan pelanggan juga dapat mengetahui informasi produk apa saja dan bagaimana disain yang tersedia di Distro Pringsewu.

Perancangan Radio Streaming Edukasi (Studi Kasus Balai Pengembangan Media Radio YOGYAKARTA)

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Nurwulan, Ayu Isni; Paputungan, Irving Vitra

2009-01-01

Pendidikan berkualitas sudah sewajarnya bisa dinikmati secara merata oleh semua orang. Mediapembelajaran secara audio yang selama ini disampaikan masih memiliki banyak keterbatasan, terutama padalingkup wilayah penyampaian. Dalam makalah ini, sebuah media pendidikan berbasis audio dengan cara laindiusulkan. Media tersebut bernama radio streaming. Pembuatan radio streaming memerlukan banyak analisissehingga perancangannya tepat. Hasil analisis dan perancangan yang disampaikan dalam makalah ini...

PENGARUH PROFESIONALISME DAN INDEPENDENSI AUDITOR INTERNAL TERHADAP KUALITAS AUDIT: STUDI PADA INSPEKTORAT PROPINSI JAWA BARAT

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Susilawati Susilawati

2015-08-01

Tujuan Penelitian ini adalah: pertama, untuk mengetahui serta menganalisis pengaruh Profesionalisme dan Independensi Auditor Internal secara simultan terhadap kualitas audit pada Inspektorat Provinsi Jawa Barat. Kedua, untuk mengetahui serta menganalisis pengaruh Profesionalisme dan Independensi Auditor Internal secara parsial terhadap kualitas audit pada Inspektorat Provinsi Jawa Barat DOI: 10.15408/etk.v13i2.1886

Pengaruh Mindset, Kepemimpinan, dan Nilai Keluarga terhadap Budaya Organisasi Perusahaan Keluarga [Influence of Mindset, Leadership, and Family Values on the Organizational Culture of Family Firms

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Maria Bella

2018-05-01

Full Text Available This research aims to find out how significant the mindset, leadership, and family values influence the organizational culture of family firms. This research is a quantitative research which uses questionnaires as the data collection method. The population of this research is the students of University of Ciputra who attend the Family Business class in the odd semester of 2016 Entrepreneurship subject. There are 59 respondents’ data which fit as samples of this research and the data is processed by using the Partial Least Square (PLS analysis method. The result of this research shows that (1 mindset significantly affects leadership, (2 leadership does not significantly affect the organizational culture of family firms, (3 mindset significantly affects family values, (4 family values significantly affect the organizational culture of family firms, (5 family values do not significantly affect leadership, (6 mindset does not significantly affect the organizational culture of family firms, and (7 the organizational culture of family firms can be formed by the leader’s mindset which are reflected through the family values believed and applied within the companies. Bahasa Indonesia Abstrak: Penelitian ini bertujuan untuk mengetahui seberapa signifikan mindset, kepemimpinan, dan nilai keluarga berpengaruh terhadap budaya organisasi perusahaan keluarga. Penelitian ini merupakan penelitian kuantitatif yang menggunakan kuesioner sebagai metode pengumpulan data. Populasi pada penelitian ini adalah mahasiswa Universitas Ciputra yang tergabung dalam kelas Family Business pada mata kuliah Entrepreneurship semester ganjil 2016. Terdapat 59 data responden yang dinyatakan layak untuk digunakan sebagai sampel penelitian dan data diolah dengan menggunakan metode analisis Partial Least Square (PLS. Hasil dari penelitian ini menunjukkan bahwa (1 mindset berpengaruh secara signifikan terhadap kepemimpinan, (2 kepemimpinan tidak berpengaruh secara signifikan

Pengaruh Rasio Modal Saham Terhadap Return Saham Perusahaan-Perusahaan Telekomunikasi Go Public di Indonesia Periode 2007

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David Wijaya

2008-01-01

Full Text Available The purpose of this research is to know the influence of market value ratio to return in the telecommunication go public companies in Indonesia. This research uses multiple regression linear method, examination of hypothesis by using t test, F test and R2 test. The result of this analysis indicates that simultaneously all independent variables (ROE, PER, BVPS, and PTBV do not have a positive and significant effect to dependent variable (return. It means that return variable influenced by other variables which do not included in this research. Partially, all independent variables (ROE, PER, BVPS, and PTBV do not have a positive and significant effect to dependent variable (return Abstract in Bahasa Indonesia: Penelitian ini bertujuan untuk mengetahui pengaruh rasio modal saham terhadap return pada perusahaan-perusahaan telekomunikasi terbuka di Indonesia. Penelitian ini menggunakan metode analisis regresi linier berganda, pengujian hipotesis dengan menggunakan uji t, uji F, dan uji R2. Hasil analisis menunjukkan bahwa secara simultan (secara bersama-sama, semua variabel independen (ROE, PER, BVPS, dan PTBV secara signifikan dan positif tidak memiliki pengaruh terhadap variabel dependen (return. Hal ini berarti bahwa variabel return dipengaruhi oleh variabel-variabel lain yang tidak termasuk dalam penelitian ini. Secara parsial, semua variabel independen (ROE, PER, BVPS, dan PTBV tidak memiliki pengaruh secara signifikan dan positif terhadap variabel dependen (Return. Kata kunci: Laba atas ekuitas, harga-laba, nilai buku per lembar saham, harga saham per nilai buku, imbal hasil

DINAMIKA PEMAHAMAN ULAMA TENTANG HADIS DAJJAL (Dari Interpretasi Tekstual Ke Interpretasi Kontekstual

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Pipin Armita

2017-12-01

Full Text Available Artikel ini bermaksud menggambarkan figur Dajjal yang disebutkan di beberapa hadis dalam kutub al-sittah dan menjelaskan bagaimana interpretasi tekstual dan kontekstual tentang hadis-hadis yang berbicara tentang masa lalu. Dalam beberapa hadis, Dajjal itu digambarkan sebagai fitnah besar yang Allah datang pada akhir masa, tetapi dia juga merupakan simbol dari wahyu yang akan datang. Dengan demikian manusia mengetahui bagaimana ciri-ciri akhir zaman, dan mengetahui tanda-tanda kedatangannya adalah suatu hal yang penting. Pada artikel ini penulis akan menjelaskan dan melakukan pelacakan terhadap hadis yang membahas secara spesifik tentang figur Dajjal secara tematik dengan metode deskriptif-analitis; dengan melakukan pelacakan tentang tradisi, takhrij al-hadis, analisis sanad, analisis muru’ah, syarah hadis secara tekstual dan kontekstual sebagai objek dari analisis yang dilakukan oleh penulis. Berdasarkan analisa penulis ada beberapa periwayat dari jalur Bukhari, terdapat wahyu dari Allah yang mengatakan Dajjal adalah seseorang yang gemuk bertubuh kemerahan, rambut keriting, salah satu matanya buta dan matanya seperti buah anggur yang matang (tidak bercahaya. Pemahaman secara tekstual tentang figur Dajjal itu adalah sesuai dengan apa yang digambarkan oleh hadis. Secara kontekstual, para ulama memahami kharakteristik seperti mata yang disebut dalam hadis merupakan sebuah simbol/metafora untuk menjelaskan kontrol terhadap apa yang terjadi hari ini, dan sebagai sebuah konspirasi untuk menguasai dunia, dan sebagai sebuah yang terkait dengan budaya Barat dan Yahudi yang penuh tipu daya, pemimpin yang salah, dan pemikiran yang cenderung duniawi

Analysis of the United States Navy Foreign Area Officer Program

Science.gov (United States)

2013-03-01

t!U ~· 1 1\\e Stcntlritl cf tbt Y.ili!Jn’ D!p~r~~mem -:tlap c~u]ad P 10 mmpszrt p:apns to mMt tbt DMdJ a! lhC ~ md tbt 011alr 0~ ~mpocvmts md 4.1.1... tbt ~ cc:mrit• OlllpCAi m which th.ty speci&lia 1\\1 .’\

Avalik kiri Vladimir Iljaševitšile / Hannes Walter

Index Scriptorium Estoniae

Walter, Hannes, 1952-2004

2012-01-01

Vastukaja Olev Miili artiklile "Faktid väljamõeldiste vastu" (Õhtuleht, 22. juuni, 1988). Olev Miili pseudonüümi all kirjutas KGB töötaja Vladimir Iljaševitš, kes 1988. aasta aprillis avaldas üleliidulise uudisteagentuuri APN ajakirjas Globus artikli, milles õigustas ja põhjendas nõukogude võimu poolt Eestis sooritatud küüditamisi

BISA ULAR MENINGKATKAN DAYA FAGOSITOSIS MAKROFAG PERITONEUM MENCIT TERHADAP KUMAN STREPTOKOKUS GRUP B SNAKE VENOM ENHANCES THE PHAGOCYTIC CAPABILITY OF PERITONEAL MACROPHAGES OF MICE AGAINST THE GROUP B STREPTOCOCCUS

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Chandramaya Siska Damayanti

2007-06-01

Full Text Available Penelitian ini bertujuan mengetahui efek pemberian bisa ular tanah (Calloselasma rhodostoma, ular kobra (Naja naja sputatrix, dan ular welang Bungarus fasciatus pada daya fagositosis makrofag peritoneal mencit terhadap kuman streptokokus grup B. Mencit diberi berbagai dosis bisa ular secara peroral selama 7 hari atau secara intravena sebanyak 3 kali dengan selang waktu penyuntikan 3 hari sekali. Di akhir percobaan

PENGEMBANGAN KOMPETENSI PROFESIONAL BERKELANJUTAN DOSEN VOKASI PADA PENDIDIKAN VOKASIONAL DI LAMPUNG

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S. Sugiyanto; S. Slamet; S. Sugiyono

2016-01-01

Tujuan penelitian ini adalah menghasilkan model pengembangan kompetensi profesional berkelanjutan bagi setiap dosen vokasi (PKPB-DV) agar memiliki kompetensi untuk dapat menjalankan tugas pokok dan fungsinya.  Metode penelitian dan pengembangan digunakan untuk menjawab pertanyaan penelitian, dengan subjek penelitian pegawai, pimpinan perguruan tinggi, dosen yang ditentukan secara purposif. Data dikumpulkan dengan pedoman wawancara dan angket serta dianalisis secara deskripsi kualitatif. Hasil...

STRATEGI PEMASARAN PUBLIC RELATIONS MD ENTERTAINMENT PADA PEMASARAN FILM HABIBIE & AINUN

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Trisna Adi Permana; Lilis Puspitasari

2015-01-01

Tujuan penelitian ini adalah untuk mengetahui perencanaan, implementasi serta evaluasi dari strategi Marketing Public Relations yang ditetapkan PR MD Entertainment pada film Habibie & Ainun pada tahun 2012-2013. Metode yang dilakukan adalah metode deskriptif yang bertujuan melukiskan secara sistematis fakta atau karakteristik populasi tertentu atau bidang tertentu secara faktual dan cermat. Hasil penelitian menunjukan PR MD Entertainment telah melakukan tahapan-tahapan atau Teknik...

Analisis Pengaruh Faktor Organisasi, Individu, Dan Lingkungan Terhadap Kinerja Karyawan Departemen Front Office Hotel Shangri-la Surabaya

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Yonggara, Natalia; Gresia, Neria

2014-01-01

Penelitian ini dilakukan di Hotel Shangri-La Surabaya, terhadap populasi sebanyak 50 responden. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh faktor organisasi, individu, dan lingkungan terhadap kinerja karyawan departemen Front Office. Berdasarkan hasil penelitian, diperoleh pengaruh yang signifikan secara serempak pada faktor organisasi, individu, dan lingkungan terhadap kinerja karyawan. Sedangkan pengaruh yang signifikan secara parsial pada faktor individu dan lingkungan. Fa...

Keabsahan Dan Kekuatan Hukum Layanan Multi Level Marketing Di Kota Manado

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Mandang, Christian Leonardo

2016-01-01

Tujuan dilakukannya penelitian ini adalah untuk mengetahui apa landasan hukum yang mendasari keabsahan layanan Multi Level Marketing dan bagaimana sebuah Perusahaan dapat memenuhi syarat untuk menjalankan sistem Multi Level Marketing. Dengan menggunakan metode penelitian yuridis normatif, maka dapat disimpulkan: 1. Kehadiran Perusahaan dan kegiatan USAha Multi Level Marketing baik secara global maupun secara nasional, khususnya kehadirannya di negara Indonesia berperan untuk membantu berbagai...

Identifikasi Dan Uji Kepekaan Kuman Aerob Pada Alpeolitis Pascapencabutan Gigi

OpenAIRE

Rehatta Yongki, Dr.med.dent

2002-01-01

Dosen Pada Bagian Konservasi dan Bedah Mulut FKG Unhas Penelitian ini bertujuan untuk mengidentifikasi kuman aerob yang dominan pada alveolitis pascapencabutan gigi dan untuk mengetahui perbedaan kepekaan kuman aerob yang dominan dari Alveolitis terhadap beberapa antiobiotik. Penelitian ini merupakan jenis penelitian deskriftif dan uji laboratorium. Sampel sebanyak 32 orang yang diambil secara Purpose Sampling. Soket diteliti secara cermat, dilakukan pengambilan usapan . Untuk mengiden...

Hubungan antara Pengetahuan dengan Cara Pencegahan Hipertensi pada Lansia di Kecamatan Medan Johor

OpenAIRE

Ginting, Firdayani

2011-01-01

Hipertensi adalah salah satu penyakit degeneratif yang banyak dialami lansia, yaitu terjadinya peningkatan secara abnormal dan terus menerus tekanan darah yang disebabkan satu atau beberapa faktor yang tidak berjalan sebagaimana mestinya dalam mempertahankan tekanan darah secara normal. Lansia yang kurang pengetahuannya mengenai hipertensi dan upaya yang kurang tepat mempunyai risiko lebih tinggi terjadinya penyakit kardiovaskular. Penelitian ini bertujuan untuk mengetahui gambaran pengeta...

PENYISIHAN LIMBAH NITROGEN DARI SISTEM AKUAKULTUR MULTITROFIK TERPADU MENGGUNAKAN TANAMAN SAYUR SEBAGAI KONVERTER FOTOAUTOTROF

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Sumoharjo Sumoharjo

2016-04-01

Full Text Available Tiga spesies tanaman sayur, kangkung darat (Ipomoea reptana, sawi (Brassica juncea, dan kemangi (Ocimum basilicum dibandingkan guna mengonversi ammonium dan nitrat nitrogen dari sistem akuakultur. Tanaman tersebut ditanam secara hidroponik menggunakan teknik rakit (rafting technique dengan tata letak rancangan acak kelompok lengkap (RAKL. Hasil percobaan menunjukkan bahwa tingkat konversi nitrogen oleh ketiga jenis tanaman berbeda secara nyata dengan tingkat retensi nitrogen tertinggi pada tanaman kangkung sebesar 0,73±0,28 g; diikuti oleh kemangi (0,30±0,17 g; dan terakhir oleh sawi (0,03±0,07 g. Secara keseluruhan ketiga tanaman mampu menyisihkan limbah nitrogen sebesar 6,70% dari total produksi TAN dari sisa metabolisme ikan yang dibudidayakan.

PROFIL RESISTIVITAS 2D PADA GUA BAWAH TANAH DENGAN METODE GEOLISTRIK KONFIGURASI WENNER-SCHLUMBERGER (STUDI KASUS GUA DAGO PAKAR, BANDUNG

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Nanang Dwi Ardi

2015-01-01

Full Text Available Makalah ini menampilkan sebuah pendekatan dalam penyelidikan rongga-rongga di bawah tanah. Akuisisi data resistivitas telah dilakukan di Gua Dago Pakar, Bandung. Lintasan resistivitas telah diukur dan dilanjutkan dengan pengukuran secara manual dengan menggunakan tali serta GPS untuk memperkirakan bentuk gua secara akurat. Sistem konfigurasi lintasan resistivitas menggunakan konfigurasi elektroda WennerSchlumberger. Pemrosesan dan pemodelan data menggunakan perangkat lunak Res2DInv dengan metode komputasi kuadrat terkecil. Hasil dari pemodelan inverse 2D menunjukkan bahwa bentuk tubuh gua berlokasi sekitar 10 – 12,4 m di bawah lintasan resistivitas dengan rentang nilai resistivitas 540-600 Ohm meter. Hasil ini dikorelasikan dengan data geologi dan pengukuran secara manual di dalam gua. Kata kunci:  Rongga, Resistivitas, Wenner-Schlumberger, Inversi

PENGARUH PEMANFAATAN SOSIAL MEDIA, MOTIVASI DAN PENGETAHUAN TERHADAP MINAT BERWIRAUSAHA PADA MAHASISWA EKONOMI DI UNIVERSITAS MUHAMMADIYAH SIDOARJO

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Muhammad Hasym Alfaruk

2017-03-01

Full Text Available Penelitian ini bertujuan untuk menganalisis pengaruh pemanfaan sosial media, motivasi dan pengetahuan terhadap minat berwirausaha pada mahasiswa Ekonomi Universitas Muhammadiyah Sidoarjo baik secara parsial maupun simultan. Penelitian yang dilakukan merupakan penelitian kuantitatif. Populasi dalam penelitian ini mahasiswa Ekonomi  angkatan tahun 2009-2010 sampai  sebanyak 650 dengan jumlah sampel sebanyak 247 mahasiswa. Metode analisis data menggunakan teknik analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa secara parsial pemanfaatan sosial media dan motivasi berpengaruh signifikan terhadap minat berwirausaha pada mahasiswa Ekonomi Universitas Muhammadiyah Sidoarjo, sedangkan Pengetahuan tidak memiliki pengaruh terhadap minat berwirausaha pada  mahasiswa Ekonomi Universitas Muhammadiyah Sidoarjo. Secara simultan pemanfaatan sosial media, motivasi dan pengetahuan berpengaruh signifikan terhadap minat berwirausaha pada mahasiswa Ekonomi Universitas Muhammadiyah Sidoarjo.

PERAN PENDIDIKAN KEWARGANEGARAAN DALAM MEMBANGUN WARGA NEGARA GLOBAL

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Sutrisno asyafiq

2018-05-01

Full Text Available Penelitian ini bertujuan untuk mengetahui gagasan pendidikan kewarganegaraan global serta peran pendidikan kewarganegaraan dalam membangun warga negara global. Penelitian ini merupakan penelitian studi literatur yang menganalisis berbagai teori tentang kewarganegaraan global dan pendidikan kewarganegaraan yang ada di Indonesia. Berdasarkan hasi penelitian menunjukkan bahwa Warga negara global merupakan bentuk pelaksanaan sistem kewarganegaraan yang mencangkup beberapa hak dan kewajiban dasar warga negara secara global. Warga negara global tentu harus disiapkan secara langsung khusunya pada jenjang sekolah dasar maupun sekolah menengah bahkan sampai perguruan tinggi. Melalui proses pendidikan kewarganegaraan yang diajarkan diharapkan mampu menstranformasikan nilai-nilai dasar warga negara global dalam berkehidupan  bermasyarakat dan bernegara. Sehingga akan mampu menyelesaikan berbagai permasalahan maupuan konflik serta isu-isu yang terjadi secara global

SIMULASI POLA MEDAN ELEKTROMAGNET PADA PANDU GELOMBANG PERSEGI DENGAN DUA PARAMETER

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Sujito

2015-10-01

Full Text Available Telah dilakukan visualisasi pola medan elektromagnetik 4 moda terendah pada pandu gelombang persegi untuk moda berorde tinggi, yaitu moda TE00, TE01, TE10 dan TE11. Konstanta propagasi sebagai salah satu parameter yang digunakan untuk mengkarakter moda gelombang optik diformulasikan secara semi analitik. Hal ini dikarenakan formulasi konstanta propagasi efektif moda gelombang tidak dapat diturunkan secara eksak. Beberapa bagian dipecahkan menggunakan penyelesaian analitik, sedangkan beberapa bagian diselesaikan melalui analisa numerik secara komputasional dengan menggunakan perangkat lunak Matlab. Analisis karakter pola medan dilakukan dengan menggunakan prinsip Variasional fungsi trial polinom Hypergeometri, sedangkan profil indeks bias berbentuk secant hyperbolik. Analisis menunjukkan bahwa penggunaan berbagai orde moda menunjukkan kesesuaian terhadap metode indeks efektif dan mampu mendeskripsikan pola medan.

Absence of E protein arrests transmissible gastroenteritis coronavirus maturation in the secretory pathway

International Nuclear Information System (INIS)

Ortego, Javier; Ceriani, Juan E.; Patino, Cristina; Plana, Juan; Enjuanes, Luis

2007-01-01

A recombinant transmissible gastroenteritis coronavirus (rTGEV) in which E gene was deleted (rTGEV-ΔE) has been engineered. This deletion mutant only grows in cells expressing E protein (E + cells) indicating that E was an essential gene for TGEV replication. Electron microscopy studies of rTGEV-ΔE infected BHK-pAPN-E - cells showed that only immature intracellular virions were assembled. These virions were non-infectious and not secreted to the extracellular medium in BHK-pAPN-E - cells. RNA and protein composition analysis by RNase-gold and immunoelectron microscopy showed that rTGEV-ΔE virions contained RNA and also all the structural TGEV proteins, except the deleted E protein. Nevertheless, full virion maturation was blocked. Studies of the rTGEV-ΔE subcellular localization by confocal and immunoelectron microscopy in infected E - cells showed that in the absence of E protein virus trafficking was arrested in the intermediate compartment. Therefore, the absence of E protein in TGEV resulted in two actions, a blockade of virus trafficking in the membranes of the secretory pathway, and prevention of full virus maturation

Sex differences in the aging pattern of renin-angiotensin system serum peptidases.

Science.gov (United States)

Fernández-Atucha, A; Izagirre, A; Fraile-Bermúdez, A B; Kortajarena, M; Larrinaga, G; Martinez-Lage, P; Echevarría, E; Gil, J

2017-01-01

Serum peptidases, such as angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and aminopeptidase A (APA), are important elements of the renin-angiotensin system (RAS). Dysregulation of these enzymes has been associated with hypertension and cardiovascular risk. In the present study, serum activities of RAS peptidases were analyzed to evaluate the existence of sexual differences, with a possible different pattern in pre- and post-andropausal/post-menopausal participants. One hundred and eighteen healthy men and women between 41 and 70 years of age (58 women and 60 men) were recruited to participate in the study. Serum RAS-regulating enzymes were measured by spectrofluorimetry. Enzymatic activity was recorded as units of enzyme per milliliter of serum (U/mL). Significantly lower serum APA activity was observed in men with respect to women; no sex differences were detected for ACE, ACE2, NEP, or APN. Significantly lower APA and ACE serum activity were observed in older men compared to older women. In contrast, younger (menopausia, on the critical serum enzymatic activities of the RAS, which could correlate with sexual differences in cardiovascular risk.

Assessment of Nuclear Power Plant Impact to the Environment: Effect of Sea Water Temperature Increase on Plankton Population

International Nuclear Information System (INIS)

Tjahaja, I P; Pujadi; Supriharyono; Aviati, N; Ruswahyun; Busono, H

1996-01-01

Research to study the effect of sea water temperature increase on plankton population had been carried out to predict nuclear power plant impact to the environment. Plankton collected from Jepara waters, Muria Peninsula, was grown on growth medium i.e. sea water enriched with silicate fertilizer. Plankton growth was maintained at temperature varied from 34oC to 46oC and the amount of plankton individu was counted twice a day until it was reduced about 95%. The results showed that the reduction of amount of plankton individu occurred on the medium with temperature above the ambient temperature (34oC). The rate of reduction is linear to the temperature increase. There is no plankton survived at temperature above 40oC for more than 24 hours

PERAN PENGALAMAN SEBAGAI PEMODERASI PADA PENGARUH PENGETAHUAN DAN SIKAP WISATAWAN MANCANEGARA TERHADAP KEPUTUSAN PEMBELIAN PRODUK WELLNESS TOURISM DI KAWASAN WISATA UBUD, KABUPATEN GIANYAR

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Dewa Putu Kiskenda Erwanda P.

2015-12-01

Full Text Available Pariwisata wellness utamanya Spa di kawasan wisata Ubud tumbuh pesat mencapai 54,17 % (dalam 3 tahun terakhir dengan jumlah sebanyak 96 Spa dengan kategori Day Spa dan Hotel and Resort Spa. Industri Spa di Ubud sebagai industri pariwisata yang akan diunggulkan kedepannya penting dalam selalu memenuhi permintaan wisatawan dengan output terciptanya keputusan pembelian secara berkelanjutan. Pengambilan keputusan sangat erat kaitanya dengan keterlibatan psikologis, favoritism dan sense of goodwill yang awalnya muncul dari internal diri wisatawan, oleh karenanya penting dilakukan penelitian dengan pendekatan pada pengetahuan, sikap dan sekaligus mengukur peran pengalaman dalam memperkuat pengaruh pengetahuan dan sikap terhadap keputusan pembelian produk wisata Spa di Ubud. Sampel dalam penelitian ini ditentukan secara purposive yaitu wisatawan mancanegara yang membeli produk layanan Spa di kawasan wisata Ubud sebanyak 250 wisatawan. Sedangkan analisis data yang dilakukan meliputi analisis deskriptif, analisis pengujian instrumen data dan Moderated Regression Analysis (MRA dengan menggunakan pendekatan interaksi. Hasil penelitian menunjukan bahwa (1 pengalaman secara signifikan berperan sebagai pemoderasi yang memperkuat pengaruh antara pengetahuan terhadap keputusan pembelian dan (2 pengalaman juga secara signifikan sebagai pemoderasi yang memperkuat pengaruh sikap terhadap keputusan pembelian produk wisata Spa di kawasan wisata Ubud.

PENERAPAN KABA MINANGKABAU SEBAGAI MEDIA PELESTARIAN BAHASA AMAI (IBU DAN KESUSASTRAAN DALAM PENDIDIKAN LITERASI DI MINANGKABAU

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Wahyudi Rahmat

2016-11-01

Full Text Available Penelitian ini mencoba menerapkan Kaba Minangkabau sebagai media pemertahanan bahasa ibu, kesusastraan dan pengajaran dalam keluarga di Minangkabau. Pengajaran ini bermakna bahwa dengan terus mempertahankan eksistensi Kaba dalam masyarakat, maka secara otomatis pelestarian bahasa ibu juga akan terus bertahan dalam perkembangan zaman. Bahasa amai atau ibu yang ada dalam kaba Minangkabau jika terus dipertahankan sebagai sebuah inovasi akan menjadikannya sebuah bahasa yang lebih mulia. Sehingga dapat dikatakan bahwa bahasa daerah  atau bahasa Minangkabau adalah sebuah bentuk kekayaan budaya yang dapat dimanfaatkan, bukan hanya sebagai sebuah kepentingan pengembangan  melainkan sebagai sebuah eksistensi bahasa itu sendiri. Penerapan Kaba Minangkabau  sebagai media pelestarian bahasa ibu ini sudah lama diterapkan pada proses belajar dan mengajar di program studi Sastra Daerah Universitas Andalas Sumatera Barat. Hasil penelitian ini menunjukkan sebagian besar mahasiswa Sastra Daerah menggunakan bahasa Minangkabau dalam berkomunikasi dan dalam situasi komunikasi ini mahasiswa Sastra Daerah mampu mengembangkan pengalaman empiris untuk pengembangan kearifan hidup dalam kaba baik secara individual maupun secara kolektif di kampus ataupun di masyarakat. Secara tidak langsung juga bahasa amai atau ibu yang ada dalam kaba Minangkabau dapat terus dipertahankan sebagai sebuah inovasi akan menjadikannya sebuah bahasa yang lebih mulia.

PENDIDIKAN BERKARAKTER ISLAMI BAGI ANAK YATIM

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Abdurohman Misno Bambang Prawiro

2017-06-01

Full Text Available Pendidikan adalah hak setiap warga Negara Indonesia, sehingga pemerintah wajib menyediakan kesempatan seluas-luasnya kepada rakyatnya agar dapat memperoleh pendidikan yang berkualitas. Pembukaan UUD 1945 alinea 4 menyatakan bahwa Negara bertujuan mencerdaskan kehidupan bangsa. Efektifitas suatu proses pembelajaran secara umum ditentukan oleh kurikulum dan system pendidikan yang diterapkan pada lingkungan  pendidikan tersebut, berkaitan dengan pendidikan yang diterapkan terhadap anak yatim maka diperlukan adanya kurikulum khusus yang dapat menjawab dan mengakomodir kebutuhan seorang anak yatim, baik secara fisik maupun secara spiritual. Penelitian ini dilakukan di Pesantren Yatim Ibnu Taimiyah Bogor dengan audience santri-santri yatim dari jenjang Madrasah Ibtidaiyyah (MI, Madrasah Tsanawiyah (MTs dan Madrasah Aliyah (MA. Secara psikologi anak-anak yatim merasa kehilangan dengan meninggal-nya salah satu orang tua mereka yaitu ayah. Hasil dari penelitian ini menunjukan bahwa hilangnya figur ayah dalam kehidupan mereka mengakibatkan mereka merasa kurang terlindungi sehingga kepribadian mereka cenderung lebih bebas. Diperlukan adanya model pendidikan yang mengarahkan dan membimbing mereka untuk menjadi manusia yang mandiri baik pada saat proses pembelajarannya ataupun hasil dari pembelajaran tersebut. Pendidikan berkarakter Islami yang memberikan pola pembelajaran yang disesuaikan dengan tingkatan umur dan kematangan spiritual menjadi sesuatu yang harus ada bagi pendidikan mereka.

Rancang Bangun Sistem Smart Charging menggunakan Panel Surya pada Robot 6WD berbasis Mikrokontroler Arduino

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made yogi hendrayanto

2018-03-01

Full Text Available Ilmu pengetahuan dan teknologi dalam bidang robotika pada saat ini berkembang dengan sangat cepat. Teknologi robotika pada dasarnya dikembangkan dengan tujuan untuk membantu manusia dalam melakukan pekerjaan tertentu, seperti pekerjaan yang berisiko tinggi, pekerjaan yang tidak bisa dikerjakan oleh tangan manusia secara langsung dan pekerjaan yang membutuhkan ketelitian tinggi. Pada saat ini, robot masih dikendalikan secara manual oleh manusia menggunakan Baterai sebagai sumber energi robot dan melakukan pengisian secara manual. Berdasarkan hal tersebut maka ada suatu keinginan untuk berkontribusi dalam pengembangan teknologi robot 6WD yaitu dengan merancang sebuah sistem Smart charging menggunakan Panel surya sebagai sumber energi untuk melakukan pengisian baterai robot secara langsung. Sistem yang dibuat, nantinya dapat membuat robot 6WD, bergerak dengan cara manual menggunakan inputan dari komputer yang dikontrol manual dari manusia. Manusia hanya perlu menggerakkan dan dapat melihat kondisi dari 2 buah baterai robot 6WD dari Komputer, kemudian komunikasi yang terjadi antara komputer dengan robot dapat dilakukan secara dua arah, agar robot dapat memberikan informasi balik kepada komputer, baik itu daya baterai, loss area dan lain sebagainya.Arduino Mega 2560 digunakan sebagai sistem utama yang mengolah semua data input dan output pada sistem. Modul HM-TRP befungsi untuk mengirimkan data dari robot ke komputer untuk ditampilkan.Pengiriman informasi robot 6WD meliputi informasi kondisi status 2 buah baterai, arus baterai, tegangan baterai, dan arah dari gerakan robot yang akan dikendalikan melalui GCS(Ground Control Station.   [TURNITIN CHECK 8%, 18042017

Analisis Finansial Dan Strategi Pengembangan Usaha Serat Kelapa (Coco Fiber)

OpenAIRE

Sitohang, Adolf Paskaris

2016-01-01

Penelitian ini bertujuan untuk menjelaskan bagaimana proses produksi usaha serat kelapa, untuk menganalisis usaha serat kelapa (coco fiber) di Kecamatan Batang Kuis sudah layak atau tidak, untuk menjelaskan strategi pengembangan yang cocok untuk usaha serat kelapa (coco fiber) di Kecamatan Batang Kuis. Penentuan daerah penelitian dilakukan secara secara purposive (sengaja) dan metode pengambilan sampel adalah purposive sampling dengan pertimbangan bahwa responden/sampel penelitian adalah ...

Pembuatan Aplikasi Web Manajemen Laundry dan Integrasi Data dengan Web Service

OpenAIRE

Refika Khoirunnisa; R. Rizal Isnanto; Kurniawan Teguh Martono

2016-01-01

Selama ini banyak dari perusahaan di bidang jasa laundry masih menggunakan pencatatan secara manual seperti menggunakan buku, sehingga setiap data tidak terintegrasi secara waktu-nyata. Oleh sebab itu, perlu dibuat penelitian untuk merancang sebuah sistem terkomputerisasi yang dapat mempermudah pencatatan dan pengolahan data keuangan laundry. Pembuatan Aplikasi Web Manajemen Laundry menggunakan bahasa pemrograman PHP, HTML, CSS, JavaScript dan basisdata MySQL sebagai tempat penyimpanan data. ...

Studi Perilaku Masyarakat Tentang Penanganan Sampah di Tinjau dari Aspek 3r di Lingkungan Perumahan Cendana Kelurahan Dulalowo Kecamatan Kota Tengah Tahun2012

OpenAIRE

Laysa, Sukmawati

2012-01-01

Penelitian ini merupakan jenis penelitian deskriptif yang bertujuan untuk memberikan gambaran mengenai perilaku masyarakat tentang penanganan sampah[ ditinjau dari aspek 3R di lingkungan Perumahan Cendana. Pengambilan sampel dilakukan secara non random dengan teknik sampling jenuh, dengan jumlah sampel merupakan keseluruhan populasi yaitu 28 rumah. Data yang diperoleh dianalisis secara univariat dengan menggambarkan masing-masing variabel melalui penskoran dan persentase pada variabel yang di...

Hubungan Multitasking Teknologi Informasi terhadap Produktivitas Kerja (Studi Kasus: Mahasiswa ITS)

OpenAIRE

Marendha, Galang Arga; Susanto, Tony Dwi; Arifiana, Isrida Yul

2016-01-01

Pada era globalisasi saat ini cara hidup individu umumnya para remaja dan dewasa yang selalu bergerak cepat dalam mendapatkan informasi terbaru agar tidak tertinggal dari yang lain memungkinkan melakukan pekerjaan secara bersamaan. Mayoritas dari individu-individu menganggap melakukan banyak pekerjaan sekaligus dapat digunakan sebagai solusi yang tepat. Dengan kemajuan teknologi saat ini dan perilaku seperti itu, banyak sekali contoh pekerjaan yang dilakukan secara bersama-sama seperti halnya...

AKUNTANSI REVALUASI TANAH DAN BANGUNAN DALAM PELEPASAN ASET TETAP PADA PERUM PERUMNAS REGIONAL VII MAKASSAR (STUDI KOMPARASI HISTORICAL COST VS FAIR VALUE)

OpenAIRE

MUSLIEM RL, MUSTAFA

2013-01-01

2013 Secara umum, akuntansi konvensional, laporan keuangan disajikan berdasarkan historical cost, yang mengasumsikan bahwa harga (unit moneter) adalah stabil. Biasa akuntansi tidak mengakui perubahan tingkat harga umum atau perubahan tertentu tingkat harga. Akibatnya, jika ada perubahan seperti daya beli, sejarah laporan keuangan adalah relevan secara ekonomi, karena tidak mencerminkan benar nilai pasar. Harus ada model tunggal untuk mengukur instrumen keuangan. model ini mengacu pada fair...

Penempatan Optimal Phasor Measurement Unit (PMU) Dengan Integer Programming

OpenAIRE

Amrulloh, Yunan Helmy

2013-01-01

Phasor Measurement Unit (PMU) merupakan peralatan yang mampu memberikan pengukuran fasor tegangan dan arus secara real-time. PMU dapat digunakan untuk monitoring, proteksi dan kontrol pada sistem tenaga listrik. Tugas akhir ini membahas penempatan PMU secara optimal berdasarkan topologi jaringan sehingga sistem tenaga listrik dapat diobservasi. Penempatan optimal PMU dirumuskan sebagai masalah Binary Integer Programming (BIP) yang akan memberikan variabel dengan pilihan nilai (0,1) yang menu...

Perbedaan Ukuran Kamar Pulpa Molar Satu Rahang Bawah pada Pasien Diabetes Melitus dan Non-Diabetes Melitus Ditinjau dari Radiografi Periapikal

OpenAIRE

Mulianingsih, Enni

2015-01-01

Diabetes melitus adalah suatu penyakit yang mengakibatkan tidak seimbangnya kemampuan tubuh dalam mengolah makanan secara efisien yang disebabkan oleh pankreas gagal memproduksi insulin atau terjadi kesalahan fungsi tubuh yang tidak bisa menggunakan insulin secara tepat. Diabetes melitus menyebabkan gangguan peredaran darah hingga sampai ke bagian pulpa gigi. Perubahan kamar pulpa pasien diabetes melitus menjadi lebih kecil dibandingkan non-diabetes melitus diakibatkan adanya gangguan peredar...

Strategi Pemasaran Public Relations Md Entertainment Pada Pemasaran Film Habibie & Ainun

OpenAIRE

Permana, Trisna Adi; Puspitasari, Lilis

2015-01-01

Tujuan penelitian ini adalah untuk mengetahui perencanaan, implementasi serta evaluasi dari strategiMarketing Public Relations yang ditetapkan PR MD Entertainment pada film Habibie & Ainun pada tahun2012-2013. Metode yang dilakukan adalah metode deskriptif yang bertujuan melukiskan secara sistematisfakta atau karakteristik populasi tertentu atau bidang tertentu secara faktual dan cermat. Hasil penelitianmenunjukan PR MD Entertainment telah melakukan tahapan-tahapan atau Teknik PR pada film Ha...

Komunikasi Getok Tular Pengantar Popularitas Merek

OpenAIRE

Harjanto, Rudy; Mulyana, Deddy

2008-01-01

Komunikasi getok tular (Word of mouth-WOM) adalah komunikasi berantai yang beredar dengan sendirinya di suatu komunitas tertentu, merujuk pada penyampaian informasi yang pada umumnya dilakukan secara lisan, informal dari seseorang kepada orang lain secara pribadi, antara dua individu atau lebih. Perkembangan teknologi memungkinkan komunikasi getok tular juga berkembang melalui internet, situs web, maupun halaman-halaman profil online, posting dalam blog-blog pribadi maupun pertukaran informas...

Visualisasi Luas Daerah Pengurasan Sumur Minyak

OpenAIRE

Sofyan, Herry

2011-01-01

Indonesia merupakan salah satu Negara penghasil minyak dan gas, Pada pertengahan dekade 1980-an, para ahli anggota Ikatan Ahli Geologi Indonesia (IAGI) menyatakan bahwa di wilayah kedaulatan Indonesia terdapat enam puluh cekungan geologi yang secara potensial mengandung sumber daya hidrokarbon. Cekungan geologi yang ternyata mengandung cadangan minyak dan gas yang dapat diproduksikan secara komersial, hingga kini berjumlah 12 cekungan, di antaranya cekungan Sumatera Utara, Sumatera Tengah, Su...

Pengaruh Customer Perceived Value Terhadap Customer Satisfaction PT. Xyz

OpenAIRE

Sucahyo, Martinus Wilman

2017-01-01

Penelitian ini membahas tentang Customer Perceived Value terhadap Customer Satisfaction PT. XYZ. Dalam penelitian ini, Customer Perceived Value diukur melalui dimensi Core Product Value, Service Value dan Relationship Value. Masing-masing dimensi ini akan diuji pengaruhnya terhadap Customer Satisfaction, baik secara simultan maupun secara parsial, serta dimensi mana yang paling berpengaruh terhadap Customer Satisfaction. Sampel penelitian berjumlah 100 pelanggan PT. XYZ. Data penelitian diola...

Meningkatkan Hard Skills dan Soft Skills Siswa melalui Model Pembelajaran Koooperatif Tipe Stad

OpenAIRE

Alfiansyah, Muhammad; Jamal, M. Arifuddin; An'nur, Syubhan

2014-01-01

Penelitian ini secara umum bertujuan untuk mendeskripsikan keefektifan model pembelajaran kooperatif tipe STAD dalam meningkatkan hard skills dan soft skills siswa SMAN 8 Barabai pada pokok bahasan fluida statis. Secara khusus untuk mendeskripsikan keterlaksanaan RPP model kooperatif tipe STAD, hard skills siswa, soft skills siswa dan respon siswa. Metode penelitian yang digunakan merupakan penelitian tindakan kelas model Kemmis dan Mc Taggart. Hasil penelitian menunjukkan bahwa terjadi pen...

Tinjauan Yuridis Kepemilikan Tanah Absentee Dikaji dari Undang-undang Nomor 5 Tahun 1960 Tentang Peraturan Dasar Pokok Agraria

OpenAIRE

Abdurahman, Sultan

2016-01-01

Tujuan dilakukannya penelitian ini adalah untuk mengetahui bagaimana Kedudukan Kepemilikan Tanah Absentee ditinjau dari Undang-Undang Nomor 5 Tahun 1960 Tentang Pokok Agraria dan bagaimana Penerapan Dari Undang-Undang Nomor 5 Tahun 1960 Tentang Pokok Agraria terhadap Tanah Yang Dimiliki Secara Absentee. Dengan menggunkan metode penelitian yuridis normatif dsimpulkan: 1. Kepemilikan tanah secara Absentee memang memunculkan fenomena dalam dunia hukum, hal ini dikarenakan kepemilikan tanah seca...

EFISIENSI PENGGUNAAN TELUR DALAM PEMBUATAN SPONGE CAKE

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Ida Ayu Putu Hemy Ekayani

2011-01-01

Penelitian ini bertujuan untuk membuat kue berpori (spong cake) dengan kualitas baik  dengan menggunakan jumlah telur minimal yang dibantu dengan penggunaan baking powder secara optimal untuk menurunkan biaya produksi yang disebabkan oleh mahalnya harga telur. Penelitian ini merupakan penelitian laboratorium (eksperimen). Analisis data dilakukan secara deskriptif. Hasil penelitian menunjukkan bahwa kualitas sponge cake terbaik dihasilkan dari dua variasi rancangan variasi kadar baking powder ...

ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI EKSPOR TEH INDONESIA KE NEGARA INGGRIS 1979-2012

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Muhammad Chadhir

2017-01-01

Salah satu hasil perkebunan di Indonesia adalah komoditi teh yang mempunyai kontribusi penting dalam menghasilkan devisa negara. Fluktuasi pada ekspor teh Indonesia secara keseluruhan baik volume maupun nilai ekspor teh Indonesia, ternyata tidak mempengaruhi besarnya ekspor teh Indonesia ke negara Inggris, besarnya ekspor teh yang dikirim dari tahun 2007-2012 mengalami kenaikan secara kontinyu dibandingkan dengan negara tujuan utama ekspor teh Indonesia lainnya yang mengalami fluktuasi. Hanya...

Pengaruh dan Pola Aktivitas Penggunaan Internet serta Media Sosial pada Siswa SMPN 52 Surabaya

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Sherlyanita, Astrid Kurnia; Rakhmawati, Nur Aini

2016-01-01

Abstrak— Perkembangan fungsi dari internet membuat internet dapat diakses bagi semua kalangan. Akhir-akhir ini, beberapa penelitian membuktikan bahwa sebagian besar pengguna internet adalah kalangan remaja. Berkembangnya media sosial secara mendunia secara tidak langsung memiliki pengaruh besar terhadap penggunaan internet bagi remaja. Fokus pada paper ini adalah penelitian seberapa besar pengaruh penggunaan internet dan media sosial bagi remaja ditinjau dari beberapa aspek serta pola aktivit...

Tipologi Kecamatan Berdasarkan Beberapa Aspek Ketenagakerjaan Kasus Propinsi Jawa Timur

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Taryoto, Andin H

1982-01-01

IndonesianKonsep Unit Daerah Kerja Pembangunan (UDKP) merupakan salah satu bentuk nyata dari USAha untuk menjadikan desa sebagai subyek pembangunan. Dengan UDKP, pembangunan di tingkat kecamatan dapat dianggap sebagai suatu sistem yang efektif dan efisien untuk mengembangkan seluruh desa dalam UDKP yang bersangkutan secara komprehensif dan terkoordinir. Kajian secara lebih mendalam tentang keadaan dan potensi kecamatan dengan demikian dianggap perlu untuk dilakukan. Tulisan ini mencoba mengga...

PENGARUH KUALITAS AKTIVA PRODUKTIF, CAPITAL ADEQUACY RATIO, DAN LOAN TO DEPOSIT RATIO TERHADAP PROFITABILITAS PADA LEMBAGA PERKREDITAN DESA

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Gede Putu Agus Jana Susila

2017-12-01

Full Text Available Lembaga Perkreditan Desa (LPD memiliki karakteristik khusus yang berbeda dengan lembaga keuangan lainnya, sehingga dalam operasionalnya perlu dilakukan pembinaan dan pengawasan. Dimana setiap LPD wajib menyampaikan laporan tentang hasil kegiatan, perkembangan dan likuiditas secara teratur setiap bulan  dan laporan tingkat kesehatan tiap tiga bulan kepada   pengawas,   Bank   Pembangunan   Daerah   Bali,   Pembina Lembaga Perkreditan Desa Kabupaten (PLPDK dan aparat (prajuru desa, sehingga diketahui perkembangan dari masing-masing LPD. Selain itu Pembina PLPDK juga berfungsi sebagai pembina teknis, pengembangan serta pelatihan bagi LPD. Tujuan dari penelitian ini adalah untuk memperoleh temuan eksplanatif yang teruji tentang, (1 pengaruh KAP, CAR, dan  LDR secara simultan terhadap Profitabilitas pada LPD Kecamatan Banjar tahun 2015-2016, (2 pengaruh KAP, CAR, dan  LDR secara parsial terhadap Profitabilitas pada LPD Kecamatan Banjar tahun 2015-2016. Identifikasi variabel-variabel yang digunakan dalam model penelitian ini dikelompokkan menjadi dua yaitu variabel bebas (independent dan variabel terikat (dependent. Variabel bebasnya adalah KAP (X1, CAR (X2, dan LDR (X3 sedangkan Variabel terikatnya adalah Profitabilitas (Y. Analisis data dilakukan secara kuantitatif dengan dilanjutkan pemilihan uji statistik yaitu: (1 uji asumsi klasik, dan (2 analisis regresi linear berganda. Tujuannya adalah menetapkan apakah variabel bebas mempunyai hubungan dengan variabel terikatnya, penetapan tingkat signifikasi dan diakhiri dengan penelitian dasar penarikan kesimpulan melalui penerimaan atau penolakan hipotesis. Berdasarkan hasil penelitian yang telah dilakukan menunjukkan bahwa, (1 Ada pengaruh yang positif dan signifikan secara simultan dari KAP (X1, CAR (X2, dan LDR (X3 terhadap profitabilitas (Y pada  Lembaga Perkreditan Desa Kecamatan Banjar Tahun 2015-2016; (2 Ada pengaruh yang positif dan signifikan secara parsial dari KAP (X1, CAR (X2

PENGGUNAAN MODEL PEMBELAJARAN PROBLEM BASED INSTRUCTION (PBI UNTUK MENINGKATKAN KEAKTIFAN DAN HASIL BELAJAR MATEMATIKA SISWA KELAS 9B SEMESTER GASAL TAHUN PELAJARAN 2014/2015 SMP NEGERI 2 TUNTANG - SEMARANG

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Tri Muah

2016-02-01

Full Text Available Penelitian tindakan kelas ini bertujuan untuk meningkatkan keaktifan dan hasil belajar matematika siswa pada materi peluang dengan penerapan model pembelajaran PBI bagi kelas 9B Semester Gasal SMP Negeri 2 Tuntang Kabupaten Semarang. Hasil penelitian kondisi awal menggunakan wawancara, observasi dan analisis butir soal, siswa kelas 9B ini memiliki keaktifan belajar yang kurang, kemudian berdampak pada hasil belajar siswa rendah juga. Berdasarkan kondisi awal tersebut, perlu dilakukan penelitian tindakan kelas untuk meningkatkan keaktifan belajar dan hasil belajar matematika siswa. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK dengan mengetahui model prosedur penelitian yang dikembangkan oleh Kemmis dan Mc Taggart berupa model penelitian yang spiral yang pada umumnya direncanakan terdiri dari dua siklus. Setiap siklus terdiri dari empat tahap yaitu: 1 tahap pelaksanaan tindakan (planning, 2 tahap pelaksanaan tindakan (acting, 3 tahap pengamatan (observing, dan 4 tahap refleksi (reflecting. Subjek penelitian ini adalah siswa kelas 9B SMP Negeri 2 Tuntang yang terdiri dari 32 orang siswa. Data diperoleh melalui tes kognitif dan lembar observasi siswa. Dari hasil penelitian ini dapat disimpulkan bahwa model pembelajaran PBI dapat meningkatkan keaktifan belajar dan hasil belajar matematika siswa. Hal ini ditunjukan dengan hasil wawancara dan observasi yang dilakukan sebelum penelitian ini dilakukan dimana keaktifan belajar siswa secara individu 14% dan keaktifan belajar siswa secara kelompok 50% dan hasil belajar matematika siswa pada materi sebelumnya juga menunjukkan hasil belajar yang rendah dimana dari 32 siswa 6.25% siswa mendapatkan nilai tuntas dengan rata-rata 34,3. Setelah dilakukan tindakan pada siklus I, terjadi peningkatan terhadap keaktifan belajar dan hasil belajar matematika. Lembar observasi pada siklus I menunjukkan keaktifan siswa secara individu meningkat menjadi 27.4% dan keaktifan belajar siswa secara kelompok 65% dan

Factors Affecting the Self-directed Learning of Students at Clinical Practice Course for Advanced Practice Nurse

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Miyoung Kim, RN, PhD, MBA, GNP

2011-03-01

Conclusions: This study demonstrated the hierarchical relationship among belongingness, self-esteem, and self-directed learning based on the conceptual framework developed by Levett-Jones and Lathlean, thus proving the usefulness of this framework for application in the field. Therefore, this study found that there are needs of high self-esteem and belongingness in order to improve self-directed learning for APN students in clinical practice.

Banc d'essai des machines de pression positive continue ...

African Journals Online (AJOL)

Le syndrome d'apnées du sommeil est une pathologie fréquente qui se manifeste par l'obstruction (de plus de 10 secondes) des voies aériennes supérieures chez l'homme pendant le sommeil. Pour le traiter, le patient dort avec un masque nasal raccordé à une machine auto-pilotée qui délivre une pression positive ...

Penempatan Optimal Phasor Measurement Unit (PMU dengan Integer Programming

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Yunan Helmy Amrulloh

2013-09-01

Full Text Available Phasor Measurement Unit (PMU merupakan peralatan yang mampu memberikan pengukuran fasor tegangan dan arus secara real-time. PMU dapat digunakan untuk monitoring, proteksi dan kontrol pada sistem tenaga listrik. Tugas akhir ini membahas penempatan PMU secara optimal berdasarkan topologi jaringan sehingga sistem tenaga listrik  dapat diobservasi. Penempatan optimal PMU dirumuskan sebagai masalah Binary Integer Programming (BIP yang akan memberikan variabel dengan pilihan nilai (0,1 yang menunjukkan tempat yang harus dipasang PMU. Dalam tugas akhir ini, BIP diterapkan untuk menyelesaikan masalah penempatan PMU secara optimal pada sistem tenaga listrik  Jawa-Bali 500 KV yang selanjutnya diterapkan dengan penambahan konsep incomplete observability. Hasil simulasi menunjukkan bahwa penerapan BIP pada sistem dengan incomplete observability memberikan jumlah PMU yang lebih sedikit dibandingkan dengan sistem tanpa konsep incomplete observability.

Reading: The Needed Skills to Catch the Meaning

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Abu Darda

2013-12-01

Full Text Available Membaca bukanlah sekedar ketrampilan memecah simbol-simbol.Membaca sesungguhnya merupakan upaya untuk memahami apa danbagaimana pola pikir sang penulis. Bahkan, mengkritisinya atau berkreasidengannya. Karena itu, membaca sesungguhnya merupakan komunikasiantara penulis dan pembacanya.Membaca tentu membutuhkan kecerdasan dan ketrampilan tertentusecara memadai pada setiap tingkatannya. Topik ini membahas ketrampilanyang dibutuhkan pada setiap tingkatan membaca.Tingkatan pertama adalah membaca literal. Disebut juga membacaekstensif. Seorang pembaca pada tingkatan ini baru memiliki kemampuanmenangkap makna secara ekplisit. Kedua adalah membaca kritis ataumembaca intensif. Pada tingkatan ini seorang pembaca sudah mampumenangkap makna secara implisit. Dia telah memiliki satu set kemampuanintelektual untuk menganalisis bahan bacaan secara objektif, fair, dan bijaksesuai dengan sikap ilmiah. Tingkatan membaca tertinggi adalah membacakreatif. Seorang pembaca dalam tingkatan ini memiliki ketrampilan untukmenghubungkan dan menerapkan hasil bacaan dalam konteks kehidupanyang lebih luas.

Penentuan Distribusi Suhu pada Permukaan Geometri Tak Tentu Menggunakan Metode Random Walk

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Balduyanus Yosep Godja

2016-05-01

Full Text Available Telah dilakukan penentuan distribusi suhu dalam keadaan tunak pada sebuah plat bergeometri tak tentu menggunakan metode Random Walk yang dilengkapi fungsi green. Setiap sisi plat dikondisikan bervariasi terhadap suhu dalam rentang 10°C sampai 100°C dengan 4 (empat konfigurasi berkeadaan steady. Persamaan Laplace yang mendeskripsikan permasalahan ini dihampiri dengan mensimulasikan sejumlah walker pada setiap titik domain permasalahan untuk kemudian secara acak disebar menuju ke setiap sisi plat. Hasil yang diperoleh untuk setiap kondisi plat menunjukkan kesalahan relatif terhadap solusi numerik metode iterasi jacobi yang telah menghampiri solusi analitik, secara rata-rata adalah 0,85%. Nilai kesalahan tersebut diperoleh dengan menggunakan 5000 walker. Penelitian ini juga mendapatkan bahwa akurasi hampiran ditentukan oleh banyaknya walker yang digunakan. Secara umum, semakin banyak jumlah walker yang digunakan maka akurasi hampiran akan semakin baik.

Analisa Beban Kerja Dengan Menggunakan Work Sampling Dan Nasa-tlx Untuk Menentukan Jumlah Operator (Studi Kasus: PT Xyz)

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Ramadhan, Rahadian; Tama, Ishardita Pambudi; Efranto, Remba Yanuar

2014-01-01

PT. XYZ merupakan pabrik yang bergerak di bidang sandang. Dalam penelitian ini, metode yang digunakan adalah pengukuran beban secara fisik dan pengukuran beban secara mental. Pada PT XYZ para pelaksana mesin sering sekali mengeluh tentang kelelahan karena harus mengoperasikan mesin yang banyak dalam sekali kerja. Untuk mengurangi kelelahan tersebut maka dibuatlah rencana penambahan jumlah karyawan tetap untuk mengurangi beban kerja setiap pelaksana mesin.. Pengukuran beban kerja menggunakan m...

PENERAPAN HACCP BUBUR BAYI BERAS MERAH TERHADAP PENERIMAAN DAN LAMA WAKTU SIMPAN

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Riska Listyanti; Lilik Hendrarini; narto narto

2017-01-01

Penelitian ini secara umum bertujuan terlaksananya penerapan HACCP untuk bubur beras me-rah yang ditujukan untuk bayi usia 6-10 bulan, dan secara khusus menetapkan perbedaan lama waktu simpan bubur tersebut antara penerapan HACCP (variasi 1) dengan penerapan HACCP tanpa pengendalian CCP persiapan bahan (variasi 2); sanitasi alat (variasi 3); penjamah (variasi 4); cara pengolahan (variasi 5); penyimpanan (variasi 6) dan penyajian (variasi 7), serta mene-tapkan perbedaan penerimaan bubur beras ...

Teknik Penanaman Eboni (Diospyros Celebica Bakh.) Di Daerah Agak Kering

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Hendromono, Hendromono

2008-01-01

Pohon eboni sebagai penghasil kayu mewah merupakan jenis yang hanya tumbuh alami di Sulawesi. Harga kayu eboni yang mahal mengakibatkan pohonnya dieksploitasi secara berlebihan dihabitat alarnnya. Untuk mencegah eboni dari kepunahan diperlukan konservasi eboni secara in-situ dan ex-situ. Tujuan penelitian adalah untuk mengetahui teknik penanaman eboni di daerah tropik yang beriklim agak kering. Penelitian menggunakan rancangan acak lengkap berkelompok dalam percobaan faktorial 2 x 3. Perlaku...

PENGARUH CAR, BOPO, DAN LDR TERHADAP ROA PADA BANK UMUM SWASTA NASIONAL DI INDONESIA

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ABIDIN, MUH. HAD

2015-01-01

2015 Penelitian ini bertujuan untuk melihat sejauh mana pengaruh CAR, BOPO, dan LDR dalam memengaruhi ROA. Dengan menggunakan metode regresi linear berganda, untuk melihat apakah CAR, BOPO, dan LDR memiliki pengaruh secara simultan dan parsial terhadap ROA. Ruang lingkup untuk penelitian ini adalah Bank Umum Swasta Nasional Devisa dengan aset terbesar dalam lima tahun terakhir, yakni pada tahun 2009 hingga 2013. Secara parsial variabel independen dalam penelitian berpeng...

Aplikasi Android Untuk Berbagai Jenis Toko Secara Online

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Gunawan, Chandra Ari; Kasih, Julianti

2016-01-01

E-Commerce as an alternative mean of transaction along with the USAge of smartphone as a tool to perform e-commerce transaction is gaining ground. This development could be seen from the emergence of numerous mobile payment applications.The USAge of mobile devices to pay for goods, services, bills, or money transfer.Stores as a location for transaction are currently in a fierce completion to gain customers, on the other hand, there are issues for the customers, the customers often do not have...

Time Management: Menggunakan Waktu Secara Efektif dan Efisien

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Antonius Atosökhi Gea

2014-10-01

Full Text Available Living in the midst of a changing business environment, which many people are burdened with more than one responsibilities, especially in a company with very high business activity and also in highly competitive industry, is imperative for the leaders of the company to be able to manage their time well in order to survive and be able to move in a sustainable manner. The concept of time management began during the industrial revolution and became a modern idea about doing things effectively and efficiently. Time management is one of the basic skills needed to be successful in life. The findings of various surveys indicated that time management enabled organizations or companies learn to survive in the face of competition and achieve a lot of success in business. 

Kajian Rumput Vetiver Sebagai Pengaman Lereng Secara Berkelanjutan

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Susilawati Susilawati

2016-12-01

Full Text Available Flores is the island in the NTT province, which has a row of volcanoes, with the mountainous topography. Transportation is state road, along the coast with high cliffs on the other side. That often causes problems during the rainy season as several landslides. Various methods are used to overcome this landslide. Studies on vetiver grass as slope protection done to secure the slopes on a sustainable basis. First, an evaluation done for the slope construction along the slope safety from Nangaroro to Aegela, which are using vetiver grass as a safety slopes in addition to other security structures. It is also done for the same job of the road from Ende to Nangaroro and Ende-Detusoko. This study covers the technical aspects, ecological, construction and sustainability of the infrastructure that has been built. Furthermore, it is done the literature study to find more appropriate method, environmentally friendly and sustainable in securing these slopes problematic. From the literature studies and the field survey done, it can be concluded and recommended several models of eco-friendly structural design of vetiver grass and geotextile for slope protection, which is based on technical-meet standard strength, ecologically-friendly environment, locally-developed local wisdom, so it is easy to construct.

UNJUK KERJA PENGOLAHAN LIMBAH CAIR TAHU SECARA BIOLOGI

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Indriyati, Indriyati; Susanto, Joko Prayitno

2016-01-01

Sebagian besar industri makanan, termasuk industri tahu membuang limbah cairnya yang mengandung bahan organik dengan kadar tinggi (lebih dari 16,483 mg/L) langsung ke badan air. Dengan menggunakan teknologi yang tepat, limbah cair ini dapat diolah lebih lanjut untuk menghasilkan produk samping berupa biogas yang mengandunggas methan sebagai substitusi energi pada industri yang bersangkutan. Desa Kalisari merupakan salah satu sentra industri UKM tahu, untuk mengolah limbah cair yang dihasilkan...

Perekayasaan mesin injeksi bakalan acuan sepatu secara sederhana

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Agustin Suraswati

1995-06-01

Full Text Available Engineering of the injection molding machine to mold a master last made of plastics was done in the simple mechanism. Machine specification is a single screw, screw diameter 40 mm, ratio L/D = 24/1, heater 220/380 V. 700 W, motor 5,5 Hp, capacity 500 cm3/ minute.

PERANAN PROFITABILITAS, SUKU BUNGA, INFLASI DAN NILAI TUKAR DALAM MEMPENGARUHI PASAR MODAL INDONESIA SELAMA KRISIS EKONOMI

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Mudji Utami

2003-01-01

Full Text Available The economic crisis which had happening in Indonesia since 1997 has already given significant effect. Stock price decreased dramatically as well as its transaction volume. Boedie, et.all and Weston and Brigham state that there are many factor influence stock price such as profitability, interest rate, inflation and exchange rate. This, the aim of this research is to find at whether profitability, interest rate, inflation and exchange rate have significant effect to fluctuation of the stock price within the economic crisis in Indonesia. The result of this research proves that the change of profitability, interest rate, inflation and exchange rate have significant influence to the fluctuation of company stock price within the period of the economic crisis. Partially, only interest rate and exchange rate have significant effect to stock price in the period of the economic crisis. Abstract in Bahasa Indonesia : Krisis ekonomi yang terjadi di Indonesia sejak tahun 1997 telah mempunyai pengaruh yang sangat signifikan. Harga-harga saham turun secara tajam demikian pula dengan volume transaksi. Boedie, Weston dan Brigham menyatakan bahwa beberapa faktor mempengaruhi harga saham, seperti profitabilitas, suku bunga, inflasi dan nilai tukar. Oleh karena itu, tujuan dari penelitian ini untuk mengetahui apakah profitabilitas, suku bunga, inflasi dan nilai tukar mempunyai pengaruh secara signifikan terhadap perubahan harga saham selama krisis ekonomi di Indonesia. Hasil penelitian ini membuktikan bahwa perubahan profitabilitas, suku bunga, inflasi dan nilai tukar mempunyai pengaruh secara signifikan terhadap perubahan harga saham badan usaha selama periode krisis ekonomi. Secara parsial hanya suku bunga dan nilai tukar mempunyai pengaruh secara signifikan terhadap harga saham selama periode krisis ekonomi tersebut. Kata kunci: profitabilitas, suku bunga, inflasi, nilai tukar.

Studi Implementasi RCM untuk Peningkatan Produktivitas Dok Apung (Studi Kasus: PT.Dok dan Perkapalan Surabaya

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Nurlaily Mufarikhah

2017-01-01

Full Text Available Dok apung merupakan salah satu fasilitas galangan yang ada di PT.Dok dan Perkapalan Surabaya, yang terdiri dari dok I,II,IV dan V. Dok apung mempunyai peran yang sangat penting dalam kegiatan reparasi kapal. Oleh karena itu, PT.Dok dan Perkapalan Surabaya melakukan tindakan perawatan untuk menjaga kinerja dok apung. Mengingat begitu pentingnya peran dok apung, maka dilakukan penelitian tindakan dan rencana perawatan yang tepat untuk meningkatkan produktivitas dok apung dengan menggunakan metode RCM. Penelitian dengan metode RCM (Reliability Centered Maintenance secara umum dibagi menjadi 2 yaitu, secara kualitatif dan secara kuantitatif. Analisa kualitatif terdiri dari FMEA (Failure Mode and Effect Analysis, FTA (Fault Tree Analysis, dan LTA (Logic Tree Analysis. Sedangkan analisa kuantitatif terdiri dari perhitungan MTTF (Mean Time to Failure, MTTR (Mean Time to Repair, penentuan reliability, dan failure rate dengan menggunakan software weibull 6++. Dari hasil analisa kualitatif terdapat 4 komponen MSI (Maintenance Significant Item, yaitu capstan, ponton, crane dan pompa. Dari hasil analisa kuantitatif didapatkan komponen yang memengaruhi reliability dok apung. Reliability yang paling rendah yaitu ponton, pompa, capstan dan crane. Penilaian reliability didasarkan pada akibat yang ditimbulkan dari kerusakan atau kegagalan komponen terhadap sistem, sedangkan nilai MTTF (Mean Time to Failure paling rendah pada crane dan pompa yaitu 120 dan 150 hari. Secara teoritis, penerapan RCM (Reliability Centered Maintennace akan meningkatkan keandalan komponen. Tindakan dan rencana perawatan yang disarankan berdasarkan metode RCM (Reliability Centered Maintenance yaitu melakukan pengecekan secara rutin serta melakukan training pada bagian maintenance mengenai konsep perawatan. Interval maintenance pada crane dan ponton  dilakukan setiap 1 bulan sekali, sedangkan interval maintenance pada capstan dan pompa dilakukan setiap 2 bulan sekali.

PENGARUH DISIPLIN DAN CARA BELAJAR TERHADAP PRESTASI BELAJAR MATA DIKLAT PRODUKTIF ADMINISTRASI PERKANTORAN STANDAR KOMPETENSI MEMAHAMI PRINSIP-PRINSIP PENYELENGGARAAN ADMINISTRASI PERKANTORAN KELAS X PROGRAM KEAHLIAN ADMINISTRASI PERKANTORAN SMK WIDYA P

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Ernawati Ernawati,

2012-10-01

Full Text Available Perumusan masalah penelitian ini adalah: adakah pengaruh disiplin belajar dan cara belajar terhadap prestasi belajar Memahami Prinsip-prinsip Penyelenggaraan Administrasi Perkantoran kelas X SMK Widya Praja Ungaran secara parsial maupun secara simultan?. Populasi penelitian ini adalah siswa kelas X Administrasi perkantoran berjumlah 91 siswa. Analisis data menggunakan analisis regresi berganda, analisis deskriptif persentase. Hasil analisis regresi linier berganda diperoleh persamaan: Y= 27,618+0,323X1+0,392X2. Uji F diperoleh Fhitung = 71,074. Secara parsial (uji t disiplin belajar (x1 diperoleh thitung = 3.321. Variabel cara belajar siswa (X2 diperoleh thitung = 3.921. Secara simultan (R2 disiplin belajar dan cara belajar siswa berpengaruh terhadap prestasi belajar sebesar 60,9%. Simpulan penelitian ini adalah disiplin belajar dan cara belajar berpengaruh terhadap prestasi belajar baik secara simultan maupun parsial. Formulation of this research is: is there any influence learning discipline and learning on learning achievement Understanding Principles Implementation Office Administration class X SMK Widya Praja Ungaran partially or simultaneously?. This study population is students of class X Administrative offices totaling 91 students. Analysis of data using multiple regression analysis, descriptive analysis of the percentage. The results of multiple linear regression analysis obtained by the equation: Y = 27.618 +0.323 X1 +0.392 X2. The F obtained Fhitung = 71.074. Partially (t test disciplinary learning (x1 obtained thitung = 3321. Variable student learning (X2 obtained thitung = 3921. Simultaneously (R2 disciplinary learning and how learning affects students' learning achievement by 60.9%. The conclusions of this research is the discipline of learning and how learning affects the learning achievement either simultaneously or partially.

Perbandingan Keefektifan Bentuk Tes Uraian dan Teslet dengan Penerapan Graded Response Model (GRM

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Purwo susongko

2013-01-01

Full Text Available Abstrak Penelitian ini bertujuan untuk menemukan: (1 perbandingan nilai fungsi informasi item pada bentuk tes uraian dan testlet secara empirik dan simulasi, (2 pengaruh banyaknya item dan ukuran sampel terhadap perbandingan nilai fungsi informasi item pada bentuk tes uraian dan testlet secara simulasi, dan (3 keakuratan pemodelan GRM pada bentuk uraian dan testlet. Data empirik diambil dari respons siswa terhadap tes bentuk uraian dan bentuk testlet dari 772 siswa SMA kelas XI yang tersebar di lima SMA di Kabupaten Tegal. Bentuk tes uraian dan testlet bersama-sama diberikan pada siswa pada akhir semester I dan di awal semester II dengan waktu tenggang minimal 1 bulan. Data pada penelitian simulasi dibangkitkan dari parameter item hasil estimasi pada penelitian empirik dengan program WinGen 2. Hasil penelitian menunjukkan bahwa: (1 secara empirik dan simulasi, tes yang disajikan dalam bentuk uraian cenderung memiliki nilai fungsi informasi item yang lebih tinggi dibanding dengan tes yang disajikan dalam bentuk testlet, (2 secara simulasi, ada pengaruh banyaknya item dan ukuran sampel terhadap perbandingan nilai fungsi informasi item pada bentuk tes uraian dan bentuk testlet, dan (3 pemodelan GRM pada bentuk tes uraian dan testlet paling akurat pada kondisi banyaknya item 20 dan ukuran sampel 2000. Kata kunci: keefektifan, bentuk tes, graded response model

Faktor – Faktor yang Berhubungan dengan Pelaksanaan Toilet Training pada Anak Usia 3-5 Tahun di PAUD Islam Cerliana Kota Pekanbaru Tahun 2016

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sherly vermita warlenda

2017-08-01

Full Text Available Toilet training pada anak merupakan suatu usaha untuk melatih anak agar mampu mengontrol dalam melakukan buang air kecil dan buang air besar. Toilet training ini dapat berlangsung pada fase kehidupan anak yaitu umur 18 bulan-2 tahun. Dalam melakukan latihan buang air kecil dan besar pada anak membutuhkan persiapan baik secara fisik, psikologis maupun secara intelektual, melalui persiapan tersebut diharapkan anak mampu mengontrol buang air besar atau kecil secara sendiri. Jenis penelitian ini adalah analitik dengan pendekatan Cross Sectional. Sampel dalam penelitian ini sebanyak 41 responden di PAUD Islam Cerliana. Teknik pengambilan sampel menggunakan teknik sampling jenuh. Pengumpulan data dilakukan dengan menggunakan kuesioner, analisis data univariat dan bivariate. Hasil penelitian di uji secara statistik dengan uji chi square pada tingkat kepercayaan 95 % menggunakan program komputer. Hasil penelitian menunjukkan. Ada hubungan yang signifikan antara pengetahuan ibu (p = 0,00, dan tidak ada hubungan yang signifikan antara pendidikan ibu, pekerjaan ibu, umur ibu, dan lingkungan dengan pelaksanaan toilet training pada anak usia 3-5 tahun di PAUD Islam Cerliana Kota Pekanbaru Tahun 2016. Diharapkan kepada ibu untuk melatih anak agar BAK dan BAB ditoilet sejak dini. Diharapkan kepada pihak sekolah khususnya para guru untuk mengajarkan toilet training sejak dini pada anak dan menghindari penggunaan diapers pada anak.

Sosioestetik: Patung Ruang Publik Kawasan Hunian Masyarakat Urban

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Gustiyan Rachmadi

2015-03-01

Full Text Available Permasalah pokok penelitian ini, bagaimana patung ruang publik di kawasan masyara- kat urban dapat bermakna secara estetik dengan memperhatikan aspek harmoni secara sosial, pragmatis, ekonomis, edukasi dan rekreasi. Sehingga patung ruang publik ini memiliki fungsi integratif bagi pengembang dunia usaha property maupun masyarakat penggunanya. Peneli- tian penciptaan karya seni ini, menawarkan konsep pengembangan  dalam merekonstruksi pemaknaan patung ruang publik yang berbasis pada keindahan lingkungan sosial kawasan hunian masyarakat urban. Kehadiran konsep yang tidak berhenti pada pemahaman keindah- an secara visual saja, melainkan estetis secara sosial. Penelitian ini bertujuan menemukan dan menghasilkan model proses kreatif penciptaan karya seni patung ruang publik yang reliable, komprehensif dan holistik sesuai dengan teks dan konteksnya. Metode kajian Sosioestetik ini melalui beberapa tahapan: (1 Eksplorasi (2 Eksperimentasi dan Improvisasi, (3 Iluminasi, (4 Presentasi dan (5 Evaluasi. Yang mencakup di dalamnya: ide, peroses penciptaan dan bentuk penyajian. Gagasan  serta konsep yang direduksi dari peristiwa pendukung yang menyertai, dituangkan dalam proses visual dan direpresentasikan dalam bentuk patung ruang publik di kawasan komplek perumahan SSP Bandung. Konstruksi proses kreatif penciptaan seni patung ruang publik ini diharapkan dapat mewakili sebagai salah satu model aplikasi esetika-sosial.   Kata kunci: sosioestetik, patung ruang publik, kawasan hunian, masyarakat urban

ALAT SOLAR TRACKER BERBASIS MIKROKONTROLER 8 BIT ATMega8535

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I Wayan Sutaya

2015-07-01

Full Text Available Penelitian yang telah dilakukan ini adalah membuat prototipe alat solar tracker. Alat ini berfungsi untuk menggerakkan modul sel surya sehingga permukaan sel surya bisa terkena sinar matahari secara maksimal. Saat ini sel surya di Indonesia banyak terpasang secara statis atau tidak dilengkapi alat solar tracker sehingga energi matahari tidak diterima secara maksimal. Hal ini menyebabkan sel surya yang terpasang di beberapa daerah di Indonesia tidak memberikan manfaat yang optimal. Alat solar tracker yang dihasilkan pada penelitian ini diharapkan sebagai solusi dari permasalahan yang ada saat ini. Mikrokontroler 8 bit ATMega8535 yang digunakan sebagai otak utama dari alat solar tracker menjadikan alat ini menjadi berbiaya murah. Serta teknik memprogram dengan bahasa assembly menjadikan alat ini tahan terhadap kegagalan sistem. Solar tracker ini sudah bisa beroperasi dengan baik dan cocok digunakan pada modul sel surya berukuran kecil.

Balanced Scorecard: Perspektif Baru dalam Menilai Kinerja Organisasi

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Barbara Gunawan

2015-12-01

Full Text Available Dengan semakin kompleksnya kondisi lingkungan organisasi, diperlukan ukuran-ukuran kinerja yang komprehensif sehingga akan terlihat kondisi berbagai sisi organisasi. Hal tersebut memberikan kejelasan arah dan sasaran bagi organisasi untuk bergerak maju baik dari sisi finansial maupun non finansial secara seimbang. Balanced Scorecard hadir untuk memfasilitasi pengukuran kinerja secara komprehensif baik dari sisi finansial dan sisi perspektif customer, internal business process, dan learning and growth dimana belum bias difasilitasi oleh pengukuran kinerja manajerial. Apabila semua sisi organisasi bias terukur maka organisasi akan dapat dikelola dengan baik seperti ungkapan “If We can count it, we can manage it”. Lebih dari itu Balanced Scorecard juga memberikan penawaran kepada organisasi akan pencapaian keunggulan kompetitif karena dengan terukurnya seluruh aspek organisasi secara komprehensif dan seimbang akan dapat memotivasi “breaktrough improvement” di berbagai bidang seperti: produk, proses, customer, dan pengembangan pasar.

MODEL ADOPSI UKM DI KUDUS TERHADAP E-COMMERCE

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Muhammad Malik Hakim

2017-04-01

Full Text Available Salah satu fungsi e-commerce adalah memungkinkan layanan pemasaran dan penjualan dapat dilakukan secara online di internet. Dengan e-commerce, pembeli dapat dengan mudah melihat produk unggulan dan bertransaksi sesuai dengan produk secara elektornik yang dipilihnya kapan dan dimana saja. Namun para pelaku UKM yang memiliki kemampuan dan fasilitas masih banyak yang belum memanfaatkan e-commerce secara optimal, yang berdampak pada kurang majunya perkembangan usahanya. Penelitian ini menjelaskan hubungan faktor-faktor yang mempengaruhi adopsi e-commerce oleh UKM dengan model UTAUT di Padurenan – Kabupaten Kudus. Hasil penelitian menunjukkan bahwa adopsi e-commerce belum efektif dikarenakan UKM belum memiliki niat dan keyakinan yang tinggi terhadap manfaat penggunaan e-commerce; kurangnya faktor pengaruh sosial dari komunitas sesama UKM; serta kurangnya dukungan fasilitas baik sarana maupun prasarana dan tenaga ahli dari pihak pembina UKM terkait.

Aplikasi Proses Pengkelatan untuk Peningkatan Mutu Minyak Nilam Aceh

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Pocut Nurul Alam

2007-12-01

Full Text Available Industri kecil minyak nilam di Nanggroe Aceh Darussalam tersebar di beberapa kabupaten yaitu Aceh Barat, Aceh Selatan, Aceh Jaya, dan beberapa daerah lainnya. Namun perolehan dan mutu minyak nilam yang dihasilkan masih tergolong rendah karena warna minyak coklat kehitaman. Untuk meningkatkan kualitas dan nilai jualnya, bisa dilakukan dengan beberapa proses pemurnian baik secara fisika maupun secara kimia. Untuk peningkatan kualitas tersebut dapat dilakukan antara lain dengan menurunkan kandungan Fe yang membuat warna minyak menjadi gelap. Hasil penelitian menunjukkan bahwa proses pemurnian dengan menggunakan senyawa pengkelat Na-EDTA sebagai senyawa pengkelat dalam pemurnian minyak nilam dapat menurunkan kandungan Fe (besi secara signifikan sebesar 60% untuk minyak nilam yang diperoleh dari hasil penyulingan petani di daerah Aceh Barat dan Aceh Selatan. Selain itu, minyak yang dihasilkan berwarna lebih cerah dan karakteristiknya memenuhi persyaratan mutu standar. Kata kunci: minyak nilam, pemurnian, pengkelat

OPINI MAHASISWA TERHADAP PERILAKU SEKS PRANIKAH

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Mega Ardina

2017-09-01

Full Text Available Tingginya angka perilaku seks pranikah berimbas pada bertambahnya jumlah pengidap HIV/AIDS, aborsi, kematian ibu dan bayi, serta permasalahan lainnya. Penelitian ini akan membahas mengenai opini mahasiswa terhadap perilaku seks pranikah di Yogyakarta dan faktor-faktor yang mempengaruhinya. Metode dasar yang digunakan dalam penelitian ini adalah metode deskriptif dengan menggunakan pendekatan mixed methods, dan strategi eksplanatoris sekuensial. Teknik pengumpulan data dilakukan menggunakan kuesioner terhadap 60 mahasiwa di Yogyakarta secara random. Analisis data secara kuantitatif dilakukan dengan menggunakan software SPSS 16.0 dan sebagai pelengkap pembahasan dilakukan analisis secara kualitatif. Hasil penelitian menunjukkan bahwa faktor-faktor yang berpengaruh terhadap opini mahasiswa adalah sikap mahasiswa terhadap perilaku seks pranikah, keluarga, dan media. Dari tiga faktor yang berpengaruh tersebut, yang memiliki pengaruh positif paling tinggi kepada opini mahasiswa adalah keluarga.Kata kunci: Opini, mahasiswa, perilaku seks pranikah

Membangun Civil Religion Pada Masyarakat Yang Plural; Dilema Pancasila Di Era Reformasi

OpenAIRE

Ruslan, Idrus

2011-01-01

Tema civil religion merupakan tema yang terkait dalam konteks sebuah negara yang plural seperti Indonesia. Arti civil religion itu sendiri secara harfiah adalah agama sipil (rakyat), akan tetapi jika dilihat secara apa adanya seakan-akan merupakan agama tersendiri. Oleh karenanya lebih tepat jika diartikan “Keberagamaan sipil”, karena memang dia tidak memiliki Tuhan, kitab suci, rasul, pendeta, biksu dan sebagainya. Indonesia dengan dasar negara Pancasila dimana kata “Tuhan” dalam sila Ketuha...

MUKHTALIF AL-HADITH

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Purwantoro Purwantoro

2016-10-01

Full Text Available Hadis bersumber dari Rasulullah, dan segala sesuatu yang disampaikan  Rasulullah adalah wahyu. Sehingga tidak dimungkinkannya pertentangan satu hadith dengan hadith yang lainnya. Namun dalam realita kita menjumpai hadis yang secara dhohir saling bertentangan. Hal inilah yang menggugah kita  bagaimana bersikap ketika menemui pertentangan hadis (mukhtalif hadith. Artikel ini membahas metodologi penyelesaian pertentangan hadis yang membantu kita untuk dapat bersikap dan memahami hadis yang secara dhohir saling bertentangan.

Geological evaluation of spent fuel storage and low-intermediate level radwaste disposal in the site of NPP candidate

International Nuclear Information System (INIS)

Sucipta; Yatim, S.; Martono, H.; Pudyo, A.

1997-01-01

Based on the consideration of techno-economy and environmental safety, the radioactive waste treatment installation (RWI), interim storage of spen fuel (ISSF) and low-intermediate level disposal shall be sited in the surrounding of NPP area. The land suitability of NPP's site candidate at Muria Peninsula as spent fuel storage and low-intermediate level radwaste disposal need to be studied. Site selection was conducted by overlay method and scoring method, and based on safety criteria which include geological and environmental aspects. Land evaluation by overlay method has given result a potential site which have highest suitable land at surrounding of borehole L-15 about 17.5 hectares. Land evaluation by scoring method has given result two land suitability classes, i.e. moderate suitability class (includes 14 borehole) and high suitability class, include borehole L-2, L-14 and L-15 (author)

Is Subdissociative Ketamine As Safe and Effective As Morphine for Pain Management in the Emergency Department?

Science.gov (United States)

Howard, Patricia Kunz; Gisness, Christine M

: Review of recent evidence with translation to practice for the advanced practice nurse (APN) role is presented using a case study module for "Intravenous Subdissociative-Dose Ketamine Versus Morphine for Analgesia in the Emergency Department: A Randomized Controlled Trial." This prospective, randomized controlled inquiry enrolled 90 patients into 2 groups (ketamine vs. morphine) for patients seeking care in an emergency department with acute pain. Data regarding pain scores were collected at baseline, 15, 30, 60, 90, and 120 min. Study subjects reporting persistent pain could receive rescue analgesia with fentanyl. Initial pain scores for the subjects in each of the groups were comparable (ketamine: 8.6; morphine: 8.5). Pain management for the 2 groups revealed similar average doses (ketamine: 21.8 mg; morphine: 7.7 mg). Although subjects in both groups reported reduction in pain scores at 15 and 30 min, no clinical significance was found. Subjects experienced greater pain relief (pain score = 0) in the ketamine group at 15 min (percentage difference 31%; 95% confidence interval [13, 49]), yet this was not sustained at the 30-min interval. There were no serious or life-threatening adverse effects in either group. This study highlights the important role of the APN in providing quality care, communication about pain management, and related follow-up care.

Inhibition of Lysyl Oxidases Impairs Migration and Angiogenic Properties of Tumor-Associated Pericytes

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Aline Lopes Ribeiro

2017-01-01

Full Text Available Pericytes are important cellular components of the tumor microenviroment with established roles in angiogenesis and metastasis. These two cancer hallmarks are modulated by enzymes of the LOX family, but thus far, information about LOX relevance in tumor-associated pericytes is lacking. Here, we performed a comparative characterization of normal and tumoral pericytes and report for the first time the modulatory effects of LOX enzymes on activated pericyte properties. Tumoral pericytes isolated from childhood ependymoma and neuroblastoma specimens displayed angiogenic properties in vitro and expressed typical markers, including CD146, NG2, and PDGFRβ. Expression of all LOX family members could be detected in both normal and tumor-associated pericytes. In most pericyte samples, LOXL3 was the family member displaying the highest transcript levels. Inhibition of LOX/LOXL activity with the inhibitor β-aminopropionitrile (βAPN significantly reduced migration of pericytes, while proliferation rates were kept unaltered. Formation of tube-like structures in vitro by pericytes was also significantly impaired upon inhibition of LOX/LOXL activity with βAPN, which induced more prominent effects in tumor-associated pericytes. These findings reveal a novel involvement of the LOX family of enzymes in migration and angiogenic properties of pericytes, with implications in tumor development and in therapeutic targeting tumor microenvironment constituents.

Health and academic success: A look at the challenges of first-generation community college students.

Science.gov (United States)

McFadden, Deanna L H

2016-04-01

Community colleges in the United States serve more than six million students and are the gateway to postsecondary education for individuals from typically underserved populations such as low-income, ethnic minorities, and first-generation college students. First-generation college students are defined as students whose adoptive or natural parents' highest level of education was a high school diploma or less. Postsecondary education has the potential to reduce both health and socioeconomic disparities. First-generation community college students face significant economic, social, and cultural barriers to academic success and are the most at risk for "dropping-out." The purpose of this brief report was to explore what is known about social, psychological, and physical factors that impede first-generation community college students' academic success. Little is known about potential health and psychological barriers experienced by first-generation community college students that impact academic achievement. Advanced practice nurses (APNs) on community college campuses are in the ideal position to identify and treat health issues, and conduct much-needed research into these areas. College health centers are an important practice setting for APNs to provide direct care to students as well as influence college policies that improve student health, well-being, and promote academic success. ©2016 American Association of Nurse Practitioners.

Binding specificity of Bacillus thuringiensis Cry1Aa for purified, native Bombyx mori aminopeptidase N and cadherin-like receptors

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Jenkins Jeremy L

2001-10-01

Full Text Available Abstract Background To better understand the molecular interactions of Bt toxins with non-target insects, we have examined the real-time binding specificity and affinity of Cry1 toxins to native silkworm (Bombyx mori midgut receptors. Previous studies on B. mori receptors utilized brush border membrane vesicles or purifed receptors in blot-type assays. Results The Bombyx mori (silkworm aminopeptidase N (APN and cadherin-like receptors for Bacillus thuringiensis insecticidal Cry1Aa toxin were purified and their real-time binding affinities for Cry toxins were examined by surface plasmon resonance. Cry1Ab and Cry1Ac toxins did not bind to the immobilized native receptors, correlating with their low toxicities. Cry1Aa displayed moderate affinity for B. mori APN (75 nM, and unusually tight binding to the cadherin-like receptor (2.6 nM, which results from slow dissociation rates. The binding of a hybrid toxin (Aa/Aa/Ac was identical to Cry1Aa. Conclusions These results indicate domain II of Cry1Aa is essential for binding to native B. mori receptors and for toxicity. Moreover, the high-affinity binding of Cry1Aa to native cadherin-like receptor emphasizes the importance of this receptor class for Bt toxin research.

Binding specificity of Bacillus thuringiensis Cry1Aa for purified, native Bombyx mori aminopeptidase N and cadherin-like receptors

Science.gov (United States)

Jenkins, Jeremy L; Dean, Donald H

2001-01-01

Background To better understand the molecular interactions of Bt toxins with non-target insects, we have examined the real-time binding specificity and affinity of Cry1 toxins to native silkworm (Bombyx mori) midgut receptors. Previous studies on B. mori receptors utilized brush border membrane vesicles or purifed receptors in blot-type assays. Results The Bombyx mori (silkworm) aminopeptidase N (APN) and cadherin-like receptors for Bacillus thuringiensis insecticidal Cry1Aa toxin were purified and their real-time binding affinities for Cry toxins were examined by surface plasmon resonance. Cry1Ab and Cry1Ac toxins did not bind to the immobilized native receptors, correlating with their low toxicities. Cry1Aa displayed moderate affinity for B. mori APN (75 nM), and unusually tight binding to the cadherin-like receptor (2.6 nM), which results from slow dissociation rates. The binding of a hybrid toxin (Aa/Aa/Ac) was identical to Cry1Aa. Conclusions These results indicate domain II of Cry1Aa is essential for binding to native B. mori receptors and for toxicity. Moreover, the high-affinity binding of Cry1Aa to native cadherin-like receptor emphasizes the importance of this receptor class for Bt toxin research. PMID:11722800

Relationship of serum adipocytokine levels with glucolipid metabolism and micro-inflammatory state in obese children

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Shen Zhao

2016-10-01

Full Text Available Objective: To analyze the relationship of serum adipocytokine levels with glucolipid metabolism and micro-inflammatory state in obese children. Methods: A total of 299 obese children and 264 normal children were included in the study, fasting peripheral venous blood was extracted to determine serum levels of adipocytokines, glucolipid metabolism and microinflammation-related indexes, and the correlation between the levels of adipocytokines and the levels of glucolipid metabolism and micro-inflammation-related indexes was further analyzed. Results: Serum leptin and Vaspin levels of observation group were higher than those of control group, and APN level was lower than that of control group (P<0.05; serum FINS, C-P, Cor, TG and LDL-C levels were higher than those of control group, and HDL-C level was lower than that of control group (P<0.05; serum hs-CRP, IL-8, IL-6 and TNF-α levels were higher than those of control group (P<0.05; serum Leptin, APN and Vaspin levels were directly correlated with the levels of above glucolipid metabolism and micro-micro-inflammatory state indexes. Conclusions: There are high expression levels of inflammatory factors and glucolipid metabolism disorder in obese children, and excessively expressed adipocytokines may be the important factors of persist and worsened obesity.

Novel biological properties of Oenothera paradoxa defatted seed extracts: effects on metallopeptidase activity.

Science.gov (United States)

Kiss, Anna K; Derwińska, Małgorzata; Dawidowska, Anna; Naruszewicz, Marek

2008-09-10

In this study, for the first time, we used the in vitro metallopeptidase model for the identification of a potential novel activity of defatted evening primrose seed extracts. Prepared extracts of different polarity (aqueous, 60% ethanolic, isopropanolic, and 30% isopropanolic) at concentrations of 1.5-100 microg/mL exhibited a significant and dose dependent inhibition of three tested enzymes. The 50% inhibition of enzymes activity showed that aminopeptidase N (APN) was the enzyme affected to the greatest extent with IC50 at the level of 2.8 microg/mL and 2.9 microg/mL for aqueous and 30% isopropanolic extracts, respectively. The activity of neutral endopeptidase (NEP) was quite strongly inhibited by the extracts as well. The HPLC-DAD analysis and bioguided fractionation led to the identification of four active compounds: (-)-epicatechin gallate, proanthocyanidin B3, oenothein B, and penta-O-galloyl-beta-D-glucose (PGG). Oenothein B has been shown previously to inhibit metallopeptidases. The three other compounds are known to inhibit angiotensin-converting enzyme (ACE), but they have not been previously reported to inhibit the NEP and APN activity. PGG and procyanidins with different degrees of polymerization, as the dominating compounds in O. paradoxa seeds, seemed to play a role in the crude extract activity.

Invasion risks posed by ornamental freshwater fish trade to southeastern Brazilian rivers

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André Lincoln Barroso de Magalhães

Full Text Available A model was developed to assess the risk of invasion of ornamental non-native fishes to six rivers in the state of Minas Gerais, southeastern Brazil, with focus on species popularity. Thirty-nine aquarium shops, in six cities, were visited monthly from January to December 2007. In each city, fish species were identified, and their biology and invasion history information was obtained from the literature. We calculated the annual frequency of occurrence and average number of specimens monthly available in stores. Quarterly water temperature and dissolved oxygen data from 1997 to 2007 were obtained for the Velhas, Muriaé, Uberabinha, Sapucaí-Mirim, Doce and Todos os Santos Rivers from public databases. The invasion risk of each species was assessed through a model comprising nine parameters grouped in four variables: (i Invasiveness (thermal and dissolved oxygen ranges, diet, parental care or fecundity, (ii History of invasions (establishment, (iii Propagule pressure (commercial success, comprising annual frequency of occurrence and number of specimens available monthly at stores, and (iv Invasibility (water temperature and dissolved oxygen in the target river compatible with the species ranges. Of the 345 ornamental fish species for sale, 332 are non-native to either Minas Gerais (n = 151 or Brazil (n = 194. Based on the proposed cutting values, in particular the compatibility between species and recipient thermal ranges, five ornamental non-native species (Cyprinus rubrofuscus, Carassius auratus, Xiphophorus hellerii, Poecilia reticulata, and P. latipinna can potentially invade the Velhas and Muriaé Rivers, four species (Cyprinus rubrofuscus, Carassius auratus, X. helleri, and P. reticulata the Uberabinha River, four species (Cyprinus rubrofuscus, Carassius auratus, X. maculatus, and P. reticulata the Sapucaí-Mirim River, three species (Carassius auratus, X. hellerii, and P. reticulata the Doce River, and three species (Cyprinus rubrofuscus

A RECONSTRUCTION OF THE THINKING OF PRIMARY SCHOOL CIVICS EDUCATION TEACHING AS YADNYA IN THE REALIZATION OF DHARMA AGAMA AND DHARMA NEGARA

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I Wayan Kertih

2015-06-01

Full Text Available Abstract: This research was aimed at testing the effectiveness of primary school Civics Education teaching when it was taken as a yadnya in affecting learning achievement in the aspects of civic knowledge, value orientation, and behavior both simultaneously and partially. The study was done as classroom action research and quasi-experimental study using the post test only control group design. The data were obtained from teachers selected purposively and from students selected using the multistage random sampling. The data were collected using the Civics knowledge test, value inventory, and the self evaluation format. The data were analyzed using descriptive statistics and multivariate variance analysis (MANOVA. The results showed: (1 descriptively, Civics Education as yadnya Teaching Model caused the students to obtain learning achievement falling into the medium category in civic knowledge, the high category in civic value orientation, and the medium category in civic behavior; (2 the implementation of Civics Education teaching as yadnya had a significant effect on Civics Education learning achievement in the aspects of civic knowledge, value orientation, and behavior both simultaneously and partially. Keywords: civics education teaching as yadnya,civics education learning achievement REKONSTRUKSI PEMIKIRAN PEMBELAJARAN PKN SD SEBAGAI YADNYA DALAM PERWUJUDAN DHARMA AGAMA DAN DHARMA NEGARA BERBASIS KONSTRUKTIVISME Abstrak: Penelitian ini bertujuan menguji efektivitas model pembelajaran PKn SD sebagai yadnya dalam memengaruhi hasil belajar pada aspek pengetahuan, orientasi nilai, dan tingkah laku kewarganegaraan baik secara bersama-sama dan parsial. Penelitian dilakukan dengan penelitian kelas dan penelitian eksperimen semu menggunakan desain postes saja dengan kelompok kontrol. Data diperoleh dari guru dan siswa yang dipilih secara purposif untuk guru dan multistage random sampling untuk siswa. Data dikumpulkan dengan metode pemberian tes

Perilaku Religiusitas dalam Ruwat

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Sunarno Sunarno

2009-11-01

Full Text Available Ruwatan sebagai bentuk budaya lokal dengan dalang ruwat sebagai tokoh yang berperan utama dalam prosesi ritual ruwatan yang memiliki religiusitas dalam mengemban tugas ngruwat. Religiusitas dalang ruwat ini adalah religiusitas yang sangat sarat dan erat dengan Agami Jawi. Penelitian dalam skripsi ini bertujuan untuk mengetahui seperti apakah religiusitas dalang ruwat, dan bagaimanakah perilaku religiusitasnya. Pertanyaan penelitian ini secara operasional adalah Secara kognitif meliputi konsepsi keTuhanan, konsepsi tentang nabi, dan konsepsi kitab suci. Secara afektif, apakah ada pengalaman-pengalaman religiusitas, dan perasaan-perasaan religius. Sedangkan secara psikomotorik meliputi, seperti apakah bentuk ritual dalang ruwat, dan bagaimanakah perilaku religiusitas riil dalam hidup sehari-hari. Informan dalam penelitian ini adalah dalang ruwat berjumlah 2 orang, dengan karakteristik (a mereka yang telah lanjut usia, atau setidak-tidaknya dalang yang telah mengawinkan anaknya dalam arti mereka yang telah matang pengetahuannya dalam hal ruwatan; (b dalang yang keturunan Kyai Panjangmas. Tokoh ini merupakan dalang kenamaan pada zaman Sultan Agung di Mataram (1613-1643M; (c mereka yang mendapatkan kepercayaan dari masyarakat, dan (d berdomisili di Surakarta. Pengumpulan data yang diperoleh dalam penelitian ini peneliti menggunakan metode wawancara, observasi, catatan lapangan, angket data diri, dan dokumentasi. Analisis data yang digunakan peneliti adalah analisa induktif deskriptif. Hasil dari penelitian ini adalah pertama, konsep keTuhanan dalang ruwat adalah konsep penghayatan terhadap Tuhan dengan tanpa adanya perpisahan antara seluruh alam semesta (panteisme. Kedua, nabi bagi dalang ruwat merupakan sosok yang sempurna. Ia memiliki kualitas-kualitas personal yang sempurna. Ketiga, seluruh alam raya adalah kitab suci Tuhan, karena seluruh jagad raya ini adalah emanasi Tuhan. Keempat, meditasi, samadhi, wening atau pujo broto

PENGARUH KEPEMIMPINAN TRANSFORMASIONAL, IKLIM ORGANISASI DAN BUDAYA ORGANISASI TERHADAP PROKRASTINASI KERJA

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Devy Sofyanty

2017-09-01

Full Text Available Abstrak - Prokrastinasi kerja berwujud perilaku menunda-nunda pekerjaan yang berakibat pada lambatnya atau tidak tercapainya target pekerjaan. Mengkaji tentang prokrastinasi kerja pada suatu perusahaan menjadi penting untuk meminimalisasi atau bahkan meniadakan faktor-faktor penyebab prokrastinasi kerja. Penelitian ini bertujuan untuk mengetahui secara empiris pengaruh kepemimpinan transformasional, iklim organisasi dan budaya organisasi secara parsial maupun simultan terhadap prokrastinasi kerja. Penelitian ini dilakukan di PT Indosurya Jakarta, teknik sampling yang digunakan adalah survey. Metode penelitian menggunakan metode kuantitatif dengan teknik survey, teknik pengumpulan data yang dilakukan melalui wawancara dan penyebaran kuesioner. Analisis data menggunakan regresi linier berganda. Berdasarkan hasil analisis, maka didapatkan temuan sebagai berikut: (1 secara bersama-sama atau simultan kepemimpinan transformasional, iklim organisasi dan budaya organisasi berpengaruh positif dan signifikan terhadap prokrastinasi kerja, (2 secara parsial kepemimpinan transformasional berpengaruh positif dan signifikan terhadap prokrastinasi kerja, (3 secara parsial iklim organisasi berpengaruh positif dan signifikan terhadap prokrastinasi kerja, (4 secara parsial budaya organiasasi berpengaruh positif dan signifikan terhadap prokrastinasi kerja.   Kata Kunci: Kepemimpinan Transformasional, Iklim Organisasi, Budaya Organisasi, Prokrastinasi Kerja   Abstract - Procrastination of work in the form of procrastination behavior that resulted in the slow or unachievable job targets. Assessing the procrastination of work in a company becomes important to minimize or even eliminate the factors that cause procrastination work. This study aims to determine empirically the influence of transformational leadership, organizational climate and organizational culture partially or simultaneously to work procrastination. This research was conducted at PT Indosurya

Menangkal Serangan SQL Injection Dengan Parameterized Query

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Yulianingsih Yulianingsih

2016-06-01

Full Text Available Semakin meningkat pertumbuhan layanan informasi maka semakin tinggi pula tingkat kerentanan keamanan dari suatu sumber informasi. Melalui tulisan ini disajikan penelitian yang dilakukan secara eksperimen yang membahas tentang kejahatan penyerangan database secara SQL Injection. Penyerangan dilakukan melalui halaman autentikasi dikarenakan halaman ini merupakan pintu pertama akses yang seharusnya memiliki pertahanan yang cukup. Kemudian dilakukan eksperimen terhadap metode Parameterized Query untuk mendapatkan solusi terhadap permasalahan tersebut.   Kata kunci— Layanan Informasi, Serangan, eksperimen, SQL Injection, Parameterized Query.

SUFI HEALING: TERAPI DALAM LITERATUR TASAWUF

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Muhammad Amin Syukur

2012-12-01

Kajian ini mengungkap tentang sufi healing, yaitu terapi di dalam literatur tentang sifisme. Kajian ini memfokuskan pada perilaku yang berasosiasi dengan sufi healing atau pencegahan penyakit, baik secara fisik maupun mental, dan kemudian menentukan aspek-aspek yang mendukung sistem terapi rasional dan empirik. Hasil yang diperoleh dari kajian ini adalah penemuan treatment alternatif atau preventif terhadap penyakit secara tepat yang sesuai dengan tuntutan masyarakat saat ini. Ditemukan bahwa sufi healing merupakan bentuk terapi alternatif yang dilakukan dengan menggunakan nilai-nilai sufisme se­bagai cara treatment atau pencegahan. Model ini telah dikenal dalam ma­syarakat sejak Islam dan sufisme berkembang. Rujukan ilmiah dari mengenai sistem kerja peng­obatan­nya dapat ditemukan dalam berbagai teori psikologi transpersonal, di mana kesadaran menjadi fokus kajian. Secara medis, pengobatan ini juga disebut psycho-neurons-endocrine-immunology, yang kesimpulannya adalah adanya hubungan antara fikiran dan tubuh dalam kesehatan manusia,

IMPLEMENTASI SISTEM INFORMASI GEOGRAFIS DAN DATA CENTER UNTUK PEMETAAN PENYEBARAN PENYAKIT DEMAM BERDARAH DI KABUPATEN PONOROGO

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Angga Prasetyo

2016-05-01

Full Text Available Perkembangan informasi penyebaran penyakit menular diperlukan oleh beberapa pihak, seperti Dinas kesehatan. Salah satu informasinya adalah mengenai penyebaran penderita demam berdarah dengue (DBD secara spasial di kabupaten Ponorogo. Keterbatasan pergerakan informasi penyebaran dan pemetaan data penderita demam berdarah yang tidak real time, menyebabkan penanganan serta proses antisipasi penyebaran di suatu daerah tertentu menjadi sangat lamban. Sistem Informasi Geografis (SIG merupakan salah satu teknologi pemetaan secara geografis yang memadukan sentuhan sistem informasi. SIG memiliki kemampuan yang sangat baik dalam memvisualisasikan data spasial berikut atribut-atributnya, memodifikasi bentuk, warna, dan simbol. Proses penyimpanan dalam suatu basis data dan berhubungan dengan persoalan serta keadaan dunia nyata (real world. Manfaat SIG secara umum memberikan informasi yang mendekati kondisi dunia nyata, memprediksi suatu hasil dan perencanaan strategis. Proses surveilan epidemologi pengamatan penyakit demam berdarah asih berdasar pada riwayat dan data pelaporan yang tidak real time, sehingga penanggulangan penyakit masih terkesan lambat.

Studi Efisiensi Penyisihan COD dalam Lindi dengan Sistem Evapotranspirasi Menggunakan Tumbuhan Sente (Alocasia macrorrhiza dan Rumput Belulang (Eleusine indica

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Badrus Zaman

2017-11-01

Full Text Available COD dalam lindi merupakan salah satu parameter yang secara umum berada pada konsentrasi yang tiggi sebagai salah satu hasil biodegradasi material organik dan anorganik dalam sampah di TPA. Sistem evapotranspirasi yang menggunakan tumbuhan lokal merupakan salah satu sistem yang menjanjikan. Penelitian dilakukan untuk mengetahui efisiensi penyisihan COD dalam lindi dengan reaktor evapotranspirasi secara kontinyu yang menggunakan tumbuhan Tumbuhan Sente (Alocasia macrorrhiza dan Rumput Belulang (Eleusine indica. Hasil uji menunjukkan efisiensi pada semua reaktor mulai sekitar hari ke 3 hingga hari ke 25 mengalami fluktuasi yang cenderung menurun (dari ± 75% menjadi ± 50%, tetapi hari selanjutnya cenderung meningkat. Pola tersebut dipengaruhi oleh peran media tanam, bakteri dalam media tanam, bakteri pada akar tumbuhan dan aktivitas metabolisme tumbuhan uji. Secara keseluruhan reaktor yang menggunakan Tumbuhan Sente (Alocasia macrorrhiza lebih fluktuatif dibandingkan denga menggunakan Rumput Belulang (Eleusine indica yang dipengaruhi pola pertumbuhan dan perkembangannya.

Perlindungan Perempuan Korban Kekerasan Perspektif Hukum Islam

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Lukman Santoso

2017-01-01

Persoalan kekerasan terhadap istri secara fisik maupun psikis, dewasa ini semakin sering terjadi di masyarakat. Realita tersebut secara faktual menunjukkan bahwa kekerasan dalam rumah tangga terhadap istri, merupakan suatu fenomena yang terkadang dianggap lazim di lingkungan masyarakat. Anggapan lazim ini tentunya tidak terlepas dari konstruksi sosial yang berkembang di tengah masyarakat bahwa suami adalah kepala keluarga dan memiliki otoritas penuh terhadap anggota keluarga termasuk isteri. Dalam konteks itu kajian ini berupaya mengupas tentang bagaimana konsep perlindungan terhadap perempuan korban KDRT dalam hukum Islam. Dalam konteks perlindungan perempuan dalam rumah tangga,teks-teks al-Qur’an memberikan banyak jawaban yang mengharuskan perwujudan hubungan rumah tangga secara ma’ruf dalam arti setara, adil dan demokratis. Hal ini menegaskan bahwa hukum Islam membawa misi perlindungan, yaitu sebagai rahmat bagi seluruh manusia di muka bumi. Hal ini juga diharmonisasikan dengan hukum perlindungan perempuan yang berlaku di Indonesia saat ini.

Pengembangan Instrumen Penilaian Mapel Sains melalui Pendekatan Keterampilan Proses Sains SD/MI

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Moh. Arif

2016-06-01

Full Text Available Penulisan artikel ini bertujuan untuk memberikan format pengembangan intrumen penilaian keterampilan proses sains SD yang masih menjadi problematika untuk menentukan pengembangan instrumen. Di samping itu, artikel ini ditulis untuk mengetahui karakteristik dan beberpa prosedur pelaksanaan penilaian proses sains SD dengan memberikan format pengembangan instrumen penialaian proses sains yang meliputi penyusunan rencana penelitian, penyusunan kisi-kisi, pembuatan soal sampai pada penganalisian butir soal. Konsep dasar penilaian yang perlu ditekankan adalah keefektivan instrumen penilaian, yang terdiri dari tiga unsur utama yakni valid (validity, reliabel (reliability, dan praktis (practicality. Berdasarkan tujuan dan perbedaan waktu pelaksanaanya, terdapat tiga jenis bentuk penilaian proses sains pada siswa Sekolah Dasar: Penilaian Diagnostik, Penilaian formatif dan Penilaian sumatif. Tes akan dianalisis secara kualitatif baik dari segi materi, konstruksi maupun bahasa. Analisis secara kuantitatif dengan pendekatan teori tes klasik yakni dengan Iteman dan analisis secara kuantitatif menggunakan pendekatan teori tes modern yakni program Bigstep.

Analisis Pengaruh Akuntabilitas Publik, Transparansi Publik dan Pengawasan Terhadap Kinerja Satuan Kerja Perangkat Daerah di Kabupaten Bungo

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Harry Eka Setiawan

2016-09-01

Full Text Available Abstract. This research is intended to analyze the influence of public accountability, public transparency and control to the SKPD performance with the local financial management as a variable intervening. The population in this study is SKPD environment Bungo district government.  The simultaneous and partial test of the hypothesis is done with test “F” and test “t” using the path analysis method. Results shows that simultaneously public accountability, public transparency, control, and local financial management, affect the performance of SKPD in Bungo district government. Partially, public accountability, public transparency, control, and local financial management affect the performance of SKPD in Bungo district government. Results shows that simultaneously public accountability, public transparency, and control, affect to local financial management. Partially public accountability, pubic transparency and control affect on local financial management, so that local financial management is not an intervening variable in this study Keywords:  Public Accountability, Public Transparency, Local Financial Management,   Abstrak. Penelitian ini bertujuan untuk menganalisis  pengaruh akuntabilitas publik, transparansi publik, dan pengawasan terhadap kinerja SKPD dengan pengelolaan keuangan daerah sebagai variabel intervening. Populasi pada penelitian ini adalah SKPD di dilingkungan  Pemerintah Kabupaten Bungo. Pengujian hipotesis secara simultan maupun parsial digunakan Uji F dan Uji t  dengan menggunakan metode analisis jalur. Hasil penilitan menunjukan bahwa secara simultan akuntabilitas publik, transparansi publik, pengawasan, dan pengelolaan keuangan daerah, berpengaruh terhadap kinerja SKPD pada Pemerintah Kabupaten Bungo. Secara parsial akuntabilitas publik, transparansi publik, pengawasan, dan pengelolaan keuangan daerah  berpengaruh terhadap kinerja SKPD pada Pemerintah Kabupaten Bungo. Secara simultan akuntabilitas publik

PENGARUH PRAKERIN, PRESTASI BELAJAR, LINGKUNGAN KELUARGA TERHADAP MINAT BERWIRAUSAHA SISWA

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Desi Indah Lestari,

2012-10-01

Full Text Available Minat siswa untuk menjadi seorang wirausaha dipengaruhi oleh faktor intern, maupun faktor ekstern, diantaranya adalah praktik kerja industri, prestasi belajar dan lingkungan keluarga. Permasalahan dalam penelitian ini adalah: Adakah pengaruh prakerin, prestasi belajar, dan lingkungan keluarga terhadap minat berwirausaha siswa baik secara parsial maupun simultan. Uji regresi menunjukkan hasil uji parsial untuk praktik kerja industri� signifikansi 0,004 < 0,05, prestasi belajar dengan signifikansi 0,000 < 0,05 dan lingkungan keluarga dengan signifikansi 0,028 < 0,05. Hasil uji simultan (Uji Fdengan signifikansi 0,000 < 0,05 berarti ada pengaruh prakerin, prestasi belajar dan lingkungan keluarga terhadap minat berwirausaha secara parsial maupun secara simultan. besarnya pengaruh secara parsial untuk variabel praktik kerja industri sebesar 11,16%, prestasi belajar sebesar 19,36% dan lingkungan keluarga sebesar 6,76%. Secara simultan sebesar 54,6% selebihnya 45,6% dipengaruhi oleh faktor lain yang tidak diteliti dalam penelitian ini. Interest of the student to become an entrepreneur is influenced by internal factors, and external factors, including the practice of industrial work, school performance and family environment. The problem in this study is: Is there any influence prakerin, academic achievement, and family environment to students' interest in entrepreneurship either partially or simultaneously. Regression test showed partial assay results for industrial work practices significance 0.004 <0.05, significant achievement by 0.000 <0.05 and a family environment with significance 0.028 <0.05. The results of simultaneous test (F test with significance 0.000 <0.05 means that there is an influence prakerin, school performance and family environment for the partial interest in entrepreneurship and simultaneously. partially to the influence of the variable work practices by industry 11.16%, 19.36% for achievement and family environment of 6

MENGGAGAS PAYUNG HUKUM BAITUL MAAL WATTANWIL (BMT SEBAGAI KOPERASI SYARI’AH DALAM BINGKAI IUS CONSTITUENDUM

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Elfa Murdiana

2016-12-01

Full Text Available Baitul Maal Wat Tanwil (BMT merupakan lembaga keuangan mikro syari’ah yang secara faktual telah memberikan pengaruh positif terhadap berlangsungnya pembangunan ekonomi di Indonesia. BMT sebagai koperasi syari’ah berada di bawah naungan Dinas Koperasi, konsekuensinya , segala aktivitas keuangan yang terjadi dilindungi oleh kebijakan Undang-undang Koperasi. Namun secara faktual keberadaan UU Koperasi justru belum mampu memberikan dasar hukum yang sesuai dengan praktik BMT yang ada. Oleh karenanya pembentukan aturan hukum yang pasti merupakan hal yang tak bisa ditunda lagi mengingat keberadaan BMT kian tumbuh dan semakin berkembang baik dari aspek jumlah maupun permodalannya. Dengan dibatalkannya UU Koperasi No.17 Tahun 2012 maka perlu bagi BMT memiliki aturan hukum tersendiri sebagai payung hukum bagi aktivitas BMT sebab Koperasi dan BMT (yang disejajarkan dengan Koperasi Syari’ah berbeda secara operasional dan prinsip. Oleh karenanya pembentukan Undang-Undang Koperasi Syari’ah sebagai dasar Hukum BMT harus segera dilaksanakan. Dalam rangka pembentukan UU Koperasi Syari’ah dalam kerangka Ius Constituendum  maka hendaknya perlu diperhatikan 3 nilai dasar , nilai dasar tersebut adalah: pertama Nilai Keadilan yang mendasari secara filosofis terbentuknya suatu aturan hukum ( Filosofiche Geltung dimana dasar ini merupakan suatu landasan ideal yang mengandung cita-cita kolektif masyarakat tentang nilai luhur yang  terkandung dalam Pancasila dan UUD 1945. Kedua adalah nilai kemanfaatan yang mendasari secara sosiologis ( soziologische geltung agar hukum memiliki kekuatan berlaku dimasyarakat. Ketika adalah nilai kepastian yang lahir sebagai dasar yuridis suatu aturan hukum( Juridische Geltung, dasar ini terkait dengan  persyaratan formal pembentukan suatu peraturan selanjutnya Landasan politis artinya bahwa keberadaan suatu aturan hukum merupakan suatu upaya menuangkan cita-cita kolektif masyarakat Indonesia dalam suatu aturan hukum melalui

Advanced Practice Nursing: A Strategy for Achieving Universal Health Coverage and Universal Access to Health.

Science.gov (United States)

Bryant-Lukosius, Denise; Valaitis, Ruta; Martin-Misener, Ruth; Donald, Faith; Peña, Laura Morán; Brousseau, Linda

2017-01-30

to examine advanced practice nursing (APN) roles internationally to inform role development in Latin America and the Caribbean to support universal health coverage and universal access to health. we examined literature related to APN roles, their global deployment, and APN effectiveness in relation to universal health coverage and access to health. given evidence of their effectiveness in many countries, APN roles are ideally suited as part of a primary health care workforce strategy in Latin America to enhance universal health coverage and access to health. Brazil, Chile, Colombia, and Mexico are well positioned to build this workforce. Role implementation barriers include lack of role clarity, legislation/regulation, education, funding, and physician resistance. Strong nursing leadership to align APN roles with policy priorities, and to work in partnership with primary care providers and policy makers is needed for successful role implementation. given the diversity of contexts across nations, it is important to systematically assess country and population health needs to introduce the most appropriate complement and mix of APN roles and inform implementation. Successful APN role introduction in Latin America and the Caribbean could provide a roadmap for similar roles in other low/middle income countries. analisar o papel da enfermagem com prática avançada (EPA) a nível internacional para um relatório do seu desenvolvimento na América Latina e no Caribe, para apoiar a cobertura universal de saúde e o acesso universal à saúde. análise da bibliografia relacionada com os papéis da EPA, sua implantação no mundo e a eficácia da EPA em relação à cobertura universal de saúde e acesso à saúde. dada a evidência da sua eficácia em muitos países, as funções da EPA são ideais como parte de uma estratégia de recursos humanos de atenção primária de saúde na América Latina para melhorar a cobertura universal de saúde e o acesso à saúde. Brasil

Problems of nuclear power development

International Nuclear Information System (INIS)

Panasenkov, A.

1982-01-01

The answers are reported given by the head of the department for peaceful uses of nuclear energy of the secretariat of the Council of Mutual Economic Assistance, Mr. A. Pasenkov to questions given him in an interview for APN. The questions were related to the current state and development of world nuclear power, nuclear safety and the attitude of the general public to nuclear power in the West and in the CMEA countries. (B.S.)

Prevalência de fatores de risco para a síndrome da apnéia obstrutiva do sono em motoristas de ônibus interestadual Prevalence of risk factors for obstructive sleep apnea syndrome in interstate bus drivers

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Carlos Alberto de Assis Viegas

2006-04-01

Full Text Available OBJETIVO: Verificar a prevalência de fatores de risco para a síndrome da apnéia obstrutiva do sono em motoristas de ônibus interestadual. MÉTODOS: Foram avaliados 262 motoristas profissionais de ônibus interestadual, de empresa brasileira baseada no Distrito Federal, por questionário para avaliar distúrbios respiratórios do Sono, Escala de Sonolência de Epworth, testes de atenção concentrada e difusa, e medidas antropométricas. RESULTADOS: Encontravam-se com o peso acima do ideal 68% da amostra estudada, dos quais 34% apresentaram circunferência do pescoço = 42 cm. Durante o trabalho os motoristas referiram uso de tabaco (27%, refrigerantes à base de cola (55%, álcool (65% e café (88%, e 28% dos motoristas apresentaram mais de dez pontos na Escala de Sonolência de Epworth. Houve ainda 36% de roncadores, 5% referiram paradas respiratórias durante o sono, 12% apresentaram sensação de sufocamento, 29% sono agitado e 48% referiram sentir sono ao dirigir. Já se envolveram em acidentes de trânsito 42% dos motoristas e em 7,6% dos casos o acidente foi devido a sonolência excessiva. Aqueles com mais de dez pontos na Escala de Sonolência de Epworth apresentaram nível de atenção concentrada comprometido e quanto maior a circunferência do pescoço e a hipersonolência, menor a atenção difusa. CONCLUSÃO: No grupo de motoristas estudados, há uso alarmante de substâncias estimulantes e alta prevalência de hipersonolência diurna, que leva a diminuição da atenção.OBJECTIVE: To determine the prevalence of risk factors for obstructive sleep apnea syndrome in interstate bus drivers. METHODS: This study involved 262 professional interstate bus drivers employed by a Brazilian company headquartered in the Federal District. The drivers were evaluated using a questionnaire designed to assess respiratory sleep disorders, the Epworth Sleepiness Scale, test of sustained attention, test of divided attention and anthropometric

Preparasi Minimal pada Pembuatan Gigi Tiruan Cekat dengan Fiber Reinforced Composite (FRC

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Aditya Ayat Santiko

2016-11-01

Full Text Available Dalam praktek sering kali dokter gigi dihadapkan pada pasien yang kehilangan gigi anterior dan ingin segera dibuatkan gigi tiruan karena alasan estetik. Gigi tiruan yang dibuat bisa berupa gigi tiruan sebagian lepasan (GTSL atau gigi tiruan cekat (GTC. Pada GTSL, adanya plat pada palatum menyebabkan rasa tidak nyaman, selain itu pasien setiap kali harus buka pasang gigi tiruan kembali sehingga cukup merepotkan. Oleh karena itu pada umumnya pasien ingin dibuatkan GTC dan hal ini memang sesuai dengan indikasi GTC. Hal yang menjadi pertimbangan pada pembuatan GTC adalah pengasahan permukaan gigi secara keseluruhan bila akan dibuat desain full crown. Pada perkembangan desain GTC ada desain yang disebut resin bonded bridge atau adhesive bridge yaitu GTC yang dibuat pada gigi abutment yang dipreparasi minimal pada bagian palatal saja dan dilekatkan secara mikromekanikal antara retainer sayap logam dan gigi yang telah dipreparasi. Pasien wan ita usia 22 tahun datang ke klinik Prostodonsia RSGM Prof Soedomo UGM karena kehilangan gigi insisif sentral kiri atas. Pada kasus ini dilakukan pembuatan GTC dengan bahan fiber reinforced composite (FRC. Pembuatan bridge dengan bahan FRC dapat dilakukan secara langsung dan tidak langsung. Pada makalah ini akan dibahas pembuatan bridge FRC secara tidak langsung yaitu dengan menggunakan gigi artlfisial komposit. Hasil menunjukkan estetis yang baik, kontrol setelah 2 bulan tidak ada perubahan warna dan pasien merasa puas dengan penampilannya, jaringan gingiva di sekitarnya normal.

Respiração oral na criança: repercussões diferentes de acordo com o diagnóstico Mouth breathing in children: different repercussions according to the diagnosis

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Renata C. Di Francesco

2004-10-01

Full Text Available A respiração oral é um sintoma freqüente na infância. A síndrome do respirador oral caracteriza-se por cansaço freqüente, sonolência diurna, adinamia, baixo apetite, enurese noturna e até déficit de aprendizado e atenção. Entretanto este sintoma apresenta diversas causas. Faz-se necessário, portanto, esclarecer detalhes sobre estes aspectos clínicos de acordo com suas causas. OBJETIVO: Comparar os achados de sonolência diurna, cefaléia, agitação noturna, enurese, problemas escolares e bruxismo em indivíduos com respiração oral; de acordo com os seguintes diagnósticos: rinite alérgica, hiperplasia adenoideana, hiperplasia adenoamigdaliana. FORMA DE ESTUDO: Estudo de coorte transversal. MATERIAL E MÉTODO: Estudo prospectivo com 142 pacientes de 2 a 16 anos, classificados em três grupos: rinite alérgica, hiperplasia adenoideana isolada e hiperplasia adenoamigdaliana. Os responsáveis dos pacientes responderam a questionário padronizado sobre os sintomas noturnos para caracterização da presença de apnéia do sono e sobre os aspectos estudados: cefaléia matinal, desempenho escolar e atenção, sonolência diurna, agitação noturna, enurese, bruxismo. RESULTADOS: A respiração oral é mais freqüente em meninos. Crianças com hiperplasia adenoamigdaliana são mais jovens. Este grupo apresenta maior freqüência de roncos e apnéia do sono, assim como mau desempenho escolar, bruxismo, enurese e agitação noturna, sendo estes sintomas relacionados com a apnéia, diferenciando-se do grupo com rinite alérgica. Não se observou sonolência diurna e cefaléia matinal significante nos grupos estudados. CONCLUSÃO: Bruxismo, enurese, agitação noturna e cefaléia estão relacionados com a apnéia do sono, sendo mais freqüente na hiperplasia adenoamigdaliana. Assim, a investigação de apnéia do sono na criança com respiração oral é fundamental e assim como a determinação da causa da respiração oral

SUMBER AGAMA DALAM PERSPEKTIF PSIKOLOGIS

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Syaiful Hamali

2017-03-01

Full Text Available Tulisan ini membahas secara konseptual tentang berbagai kebutuhan dasar manusia sebagai sumber kehidupan bagi manusia dalam ranah psikologis. Melalui eksplorasi-psikologis diperoleh fakta bahwa ada berbagai macam kemampuan dasar yang dimiliki manusia yang dapat dikembangkan guna menunjang hidup dan kehidupannya. Sedangkan melalui pengamatan potensi-diri diperoleh fakta bahwa dalam diri manusia tersimpan sejumlah kemampuan bawaan, termasuk diantaranya adalah potensi untuk percaya pada supernatural (agama. Sinergi antara eksplorasi-psikologis dengan potensi-diri manusia akan membentuk sumber-sumber keyakinan terhadap agama secara psikologis. Karena itu, dalam konteks ini, tanpa adanya wahyu pun sesungguhnya manusia akan mampu mengenal Tuhan. Wahyu hanya berfungsi sebagai pemberitaan dari alam metafisika yang turun kepada manusia untuk menerangkan tentang Tuhan sekaligus kewajiban-kewajiban yang harus dilakukan manusia terhadap Sang Khalik maupun sesamanya. Singkatnya secara psikologis, siapa mengenal dirinya, niscaya ia akan mengenal Tuhannya. Karena itu manusia wajib mempercayai dan meyakini akan adanya Tuhan serta melaksanakan ajaran-ajaran agama dalam kehidupannya.

Identifikasi Telapak Tangan menggunakan Jaringan Syaraf Tiruan Learning Vector Quantization (LVQ

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Sutikno Sutikno

2016-11-01

Full Text Available Sistem pengenalan diri (personal recognition adalah sebuah sistem untuk mengenali identitas seseorang secara otomatis dengan menggunakan computer dengan kata sandi (password, ID card, atau PIN untuk mengidentifikasi seseorang. Namun,pengenalan diri dengan sistem tersebut memiliki beberapa kelemahan yaitu dapat dicuri dan mudah diduplikasi, memiliki kemungkinan seseorang untuk lupa dan beberapa password dapat diperkirakan sehingga dapat dimanfaatkan oleh orang-orang yang tidak bertanggungjawab. Untuk dapat mengenali seseorang secara otomatis dapat dilakukan secara komputasi, yaitu dengan menggunakan jaringan syaraf tiruan. Penelitian ini mengimplementasikan metode jaringan syaraf tiruan Learning Vector Quantization dengan objek pengenalan yaitu telapak tangan. Dalam penelitian ini model proses pengembangan perangkat lunak yang digunakan adalah Waterfall, sedangkan bahasa pemrograman yang digunakan adalah Matlab, dan sistem manajemen basis datanya adalah Microsoft Access. Keluaran dari aplikasi yang dikembangkan adalah identifikasi telapak tangan user. Dari hasil pengujian, tingkat akurasi dari aplikasi ini sebesar 74,66% dalam membedakan antar user yang satu dengan yang lain.

KAJIAN KONSERVASI Pinus merkusii strain Tapanuli DI SUMATERA

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Hendi Suhendi

2017-01-01

Full Text Available Di Indonesia, Pinus yang tumbuh secara alami hanyalah Pinus merkusii di Sumatera yang terdiri dari strain Tapanuli, strain Kerinci dan strain Aceh. Berdasarkan persebarannya, strain Tapanuli tidak banyak dijumpai karena tercampur dengan jenis-jenis kayu daun lebar. Secara alami, strain Tapanuli ditemukan di Cagar Alam Dolok Sipirok dan Cagar Alam Dolok Saut. Dalam bentuk hutan tanaman, strain Tapanuli dibuat oleh masyarakat atau rakyat dengan anakan alam dan diambil secara cabutan di Tegakan Benih Dolok Tusam, dan sekarang sudah habis ditebang karena digantikan oleh tanaman kopi. Di wilayah kerja Dinas Kehutanan Propinsi Sumatera Utara hampir tidak pernah didapatkan informasi tentang keberadaan strain Tapanuli. Konservasi in situ dalam bentuk Cagar Alam perlu dilengkapi dengan konservasi ex situ. Sebagai langkah awal konservasi, terlebih dahulu perlu dikaji permudaan alamnya. Di samping itu, analisis kebijakan berkaitan dengan pentingnya eksplorasi dengan metode sensus pada semua kawasan konservasi di Sumatera perlu dipertimbangkan, dan pertemuan formal antar pengambil kebijakan di Departemen Kehutanan perlu direkomendasikan

Perancangan dan Implementasi Kontroler PID Gain Scheduling untuk Gerakan Lateral Way-to-Way Point pada UAV Quadcopter

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Tri Awan Nusa Putra

2013-09-01

Full Text Available Quadcopter diharapkan dapat bergerak secara lincah dan efektif menyusuri lintasan horisontal. Berdasar hukum fisisnya, gerak lateral dapat terjadi karena adanya daya angkat dan terjadinya perubahan sudut dari quadcopter tersebut. Mengacu pada hal tersebut, sudut-sudut gerak pada quadcopterakan menjadi parameter untuk gerak maju atau menyamping yang secara langsung juga berpengaruh pada gerak vertikal. Pada saat proses hoveratau melayang, adalah saat yang paling riskan pada quadcopter. Sehinga pengaturan hover dari quadcopter menjadi prioritas pada riset ini, karena apabila terjadi kesalahan hoverakan menyebabkan perubahan gerak terhadap sumbu X, Y maupun Z. Pada tugas akhir ini digunakan kontroler PID dan metode gainscheduling dengan nilai parameter penguatan yang diperoleh secara eksperimental untuk pengaturan gerak lateral menyusuri lintasan. Apabila menggunakan metode PID biasa, maka diperoleh penurunan ketinggian yang drastis hingga 50% dari total ketinggian quadcopter, namun apabila menggunakan metode PID GainScheduling, pada simulasi hanya terjadi penurunan ketinggian sebesar 0,35% dan saat implementasi mengalami sekitar 10% dari total ketinggian yang dicapai.

DAMPAK PROGRAM RESITASI TERHADAP PERUBAHAN KONSEPTUAL MAHASISWA PADA TOPIK HUKUM III NEWTON

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Ida Bagus Rini Jayanti

2016-02-01

Melalui penelitian ini telah dikembangkan program resitasi berbantuan komputer berisi 9 soal-soal konseptual dalam bentuk pilihan ganda beserta balikan langsung. Penelitian ini dimaksudkan untuk menyelidiki dampak program tersebut terhadap penguasaan konsep dan perubahan konsep mahasiswa mengenai hukum III Newton. Data diambil melalui pretes berupa tes pilihan ganda yang diberikan setelah pembahasan topik kinematika (satu dan dua dimensi dan dinamika partikel (hukum-hukum Newton tentang gaya dan gerak dan postes diberikan setelah menggunakan program resitasi. Program digunakan mahasiswa selama seminggu secara offline. Subjek penelitian terdiri atas 35 mahasiswa tahun pertama Program Studi Pendidikan Fisika Universitas Negeri Malang yang sedang menempuh mata kuliah Fisika Dasar I. Hasil penelitian ditemukan bahwa penguasaan konsep mahasiswa secara keseluruhan meningkat secara signifikan dengan nilai N-gain sebesar 0.31 dan perubahan konsep mahasiswa semakin baik dengan meningkatnya jumlah mahasiswa yang memiliki pemahaman mantap dan pemahaman sebagian, serta berkurangnya jumlah mahasiswa yang mengalami miskonsepsi dan yang tidak paham.

RANCANG BANGUN MODEL PERANGKAT LUNAK INFORMASI UKM KOTA PALEMBANG

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Ahmad Haidar Mirza

2017-11-01

Full Text Available Usaha Kecil dan Menengah (UKM merupakan suatu kegiatan usaha menghasilkan suatu produk komoditi yang berada pada level menengah kebawah, dimana sektor usaha ini lebih menyentuh langsung dalam hal peningkatan kesejahteraan masyarakat luas yang pada umumnya adalah masyarakat menengah kebawah, sektor usaha UKM mampu memberikan pertumbuhan ekonomi yang signifikan walaupun pertumbuhannya tidak cepat seperti sektor perekonomian yang lain. Rancang bangun model perangkat lunak UKM Kota Palembang diharapkan mampu memberikan stimulus yang pesat terhadap pertumbuhan ekonomi khususnya sektor UKM Kota Palembang serta membantu pihak – pihak yang terkait baik instansi yang membutuhkan, masyarakat luas dan para inventor, dimana dalam mengembangkan rancang bangun model perangkat lunak UKM Kota Palembang meggunakan 2 metode yaitu metode Database Lifecylce untuk pengembangan Database sebagai media penyimpanan data melalui beberapa proses antara lain Design Database secara Konseptual, Design Database secara Logikal serta Design Database secara Fisikal dan metode Rapid Application Development (RAD untuk pengembangan User Interface sebagai rancangan tampilan terhadap rancang bangun model perangkat lunak UKM Kota Palembang.

Analisa Alternatif Revitalisasi Pasar Gubeng Masjid Surabaya dengan Metode Highest And Best Use

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Marsha Swalia Mustika

2017-01-01

Full Text Available Dalam era globalisasi ini banyak bermunculan pasar-pasar modern yang dibangun dengan segala kelebihan dan fasilitasnya. Munculnya pasar-pasar modern membuat keberadaan pasar tradisional tersudut, tidak terkecuali Pasar Gubeng Masjid Surabaya. Namun keberadaan pasar yang strategis yaitu dekat dengan perkantoran, hotel dan pusat perbelanjaan, serta stasiun kereta api membuat pasar tersebut memiliki potensi untuk dikembangkan menjadi properti yang memberikan nilai lahan tertinggi dan terbaik. Oleh karena itu, perlu dilakukan analisa Highest and Best Use (HBU yang dapat memberikan masukan untuk melakukan investasi terbaik. Analisa HBU ini menggunakan empat kriteria yaitu secara fisik dimungkinkan, secara legal diizinkan , secara finansial layak, dan memiliki produktivitas maksimum. Alternatif yang memiliki produktivitas maksimum tersebut dapat dijadikan sebagai nilai lahan tertinggi dan terbaik pada lahan Pasar Gubeng Masjid Surabaya. Dari hasil penelitian didapatkan alternatif yang menghasilkan nilai lahan tertinggi dan produktivitas maksimum adalah alternatif pengembangan multi use pasar dengan pusat perbelanjaan.. Nilai lahan yang didapatkan sebesar Rp 46.946.524,-/m2 dengan produktivitas meningkat sebesar 312%.

Kerangka Investigasi Forensik Pada Peladen Pertukaran Berkas Samba Berdasarkan SNI ISO/IEC 27037:2014

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Dedy Haryadi

2017-07-01

Full Text Available Network File System (NFS dan Common Internet File System (CIFS merupakan protokol yang biasa dipakai dalam melakukan pertukaran berkas di dalam sebuah jaringan komputer yang terhubung dengan Network Attached Storage. Mudahnya dalam bertukar berkas dalam sebuah jaringan tidak menutup kemungkinan adanya pertukaran berkas yang bersifat ilegal ataupun berkas yang mengandung tindak kejahatan. Oleh karena itu, diperlukan sebuah model pendekatan investigasi forensik dalam proses pertukaran berkas di sebuah jaringan komputer. Proses akuisisi dalam penelitian ini dilakukan dengan 2 model, yaitu: akuisisi secara langsung pada mesin peladen file-sharing dan akuisisi secara langsung melalui jaringan. Akuisisi secata langsung pada mesin peladen berfokus pada proses akuisisi log dari mesin peladen yang dihasilkan dari layanan samba dan direktori pertukaran berkas. Akusisi secara langsung melalui jaringan berfokus pada direktori pertukaran berkas yang diakses oleh pengguna. Model akuisisi ini berdasarkan SNI ISO/IEC 27037:2014 tentang Pedoman Identifikasi, Pengumpulan, Akuisisi dan Preservasi Bukti Digital yang fokus pada barang bukti elektronik kritis dengan kondisi tidak diperkenankan mati atau shutdown.

Audit Keamanan SIMAK Berdasarkan ISO 27002 (Studi Kasus: FE UNUD

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Yulius C. N. Bless

2016-01-01

Full Text Available Keamanan sistem informasi merupakan sebuah bagian vital yang menjadi perhatian khusus bagi setiap orang yang aktif menggunakan teknologi internet sebagai alat komunikasi dan informasi. Institusi pendidikan seperti universitas, yang menggunakan sistem informasi sebagai salah satu cara dalam manajemen informasi terkait administrasi pegawai dan mahasiswa, maupun informasi lainnya guna menunjang proses pengambilan keputusan. Sistem Informasi Manajemen Akademik (SIMAK di Fakultas Ekonomi Universitas Udayana berfungsi untuk manajemen data akademik mahasiswa. Informasi yang diolah dalam SIMAK haruslah memenuhi CIA (Confidentiality, Integrity, dan Availability. Audit dilakukan agar dapat diketahui tingkat kematangan sistem informasi saat ini. Standar dalam proses audit SIMAK menggunakan ISO/IEC 27002:2005 dan COBIT 4.1 untuk proses pemetaan dan penyusunan rekomendasi. Tingkat kematangan SIMAK saat ini adalah 3 atau Well Defined. Secara umum, tingkat kematangan ini dimaksudkan bahwa sudah terdapat prosedur yang standar dan telah didefinisikan secara baik, namun pelaksanaannya masih belum dilakukan secara rutin dan terstruktur.   Kata kunci: audit, COBIT 4.1, ISO/IEC 27002:2005, tingkat kematangan.

PENILAIAN KONDISI TRANSFORMATOR DAYA PADA PT.X

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Badaruddin Badaruddin

2016-10-01

Full Text Available Transformator daya merupakan peralatan yang vital dalam penyaluran energi listrik dari unit pembangkit menuju sistem jaringan saluran tegangan. Kehandalan transformator daya sangat penting untuk keberhasilan operasi dari sistem tenaga listrik. Untuk itu dilakukan pendekatan sistematis dengan cara mengetahui kondisi peralatan komponen utama dari transformator daya tersebut. Transformator secara ideal memiliki useful life sesuai dengan design life yang direkomendasikan yaitu 30 tahun. Sedangkan transformator daya PT X sudah tidak berada dalam range useful life, dimana transformator daya tersebut diproduksi oleh Takaoka Electric pada tahun 1976. Oleh karena factor usia transformator yang sudah berumur maka diperlukan inspeksi khusus secara mendalamsebagai pendukung untuk membuat keputusan pembatasan operasi atau keputusan investasi pembangkit secara tepat dan tidak merugikan unit pembangkit itu sendiri. Untuk itu penulis melakukan serangkaian pengujian dan analisa penilaian kondisi transformator daya PT X untuk memperoleh nilai kondisi dengan mengacu  pada referensi penilaian HAP (Hydro Power Advancement Project. Hasil penilaian kondisi diharapkan nantinya akan digunakan sebagai bahan pendukung tindak lanjut pengambilan keputusan oleh PT. X.

ARSITEKTUR DVD (Digital Virtual Design

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Danny Santoso Mintorogo

2000-01-01

Full Text Available Soon after the millennium year of 2000 and toward 21th century, the ways of architecture design will be a great change from traditional hand design and drawings to super computer digital virtual design models with tremendous of high-end architectural 3D software domains. Virtual Technology will be a plus to architectural design stage to obtain several "scheme" and observe with real - time feedback of the quality (height, light, furniture, shape, and environment as well as the sequential of the space, site context or massing studies. Abstract in Bahasa Indonesia : Strategi dalam desain arsitektur pada abad 22 atau setelah tahun milinium 2000 ini akan banyak didominasi dengan perangkap teknologi canggih yang tentunya akan mengandalkan pada perangkap keras (komputer dan perangkap lunak (software untuk tujuan desain arsitektur secara digital. Teknologi "Virtual" akan dimanfaatkan untuk bidang arsitektur dalam mengoptimasikan disain arsitektur secara digital maya, untuk mengobservasi/mengkaji kwalitas ruang, model suatu ruang/massa secara maya dalam phase perancangan arsitektur. Kata kunci: arsitektur, desain, digital, maya.

PENGEMBANGAN SISTEM HRM TERINTEGRASI DENGAN PENDEKATAN ERP

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Christine Regilia Suwu

2016-12-01

Full Text Available Human Resources Management merupakan salah satu instrumen yang penting bagi perusahaan dalam pencapaian tujuannya. Penggunaan sistem informasi yang terintegrasi merupakan salah satu unsur penting untuk mengelola bisnis proses dalam manajemen perusahaan. ERP merupakan sistem informasi terintegrasi yang dimaksud dalam upaya peningkatan kualitas perusahaan. Khususnya untuk perusahaan distributor, pengelolaan proses bisnis secara konvensional dapat berpengaruh pada kualitas performa dari perusahaan itu sendiri. Berfokus pada HRM perusahaan distributor, penelitian membahas mengenai implementasi bisnis proses human resource management menggunakan software ERP yaitu Odoo. Penelitian dilakukan dengan menganalisa bisnis proses yang ada kemudian merancang sistem usulan yang terintegrasi lalu diimplementasikan ke dalam Odoo. Pemodelan sistem dirancang untuk mengoptimalkan pengelolaan data yang masih diproses secara konvensional. Optimalisasi dalam setiap proses bisnis meningkatkan kualitas keamanan dengan adanya pengaturan hak akses user dan keakuratan data yang didapat dengan transaksi data yang real time, serta efisiensi waktu yaitu memperkecil durasi waktu yang diperlukan untuk pencatatan dan penyimpanan dokumen dibanding secara manual. Kata Kunci: Sistem Informasi, Human Resources Management, ERP, Bussines Process Management

HUKUM, MORAL, DAN KEKUASAAN DALAM TELAAH (Hukum adalah Alat Teknis Sosial

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Fithriatus Shalihah

2017-04-01

Abstrak Dampak negatif penggunaan hukum sebagai sarana perubahan masyarakat dalam negara otoriter terlihat sudah secara terang benderang ketika berkuasanya sebuah rezim yang puluhan tahun berkuasa di Indonesia. Rezim tersebut mengatasi semua kekuatan yang ada dalam masyarakat dan birokrasinya sangat menentukan. Partai-partai politik pada era itu tidak mandiri. Keputusan-keputusan di bidang legislasi lebih banyak diwarnai oleh visi politik pemerintah. Disini hukum telah dijadikan identik dengan kekuasaan, sehingga tidak dapat dibedakan lagi secara tegas, mana hukum mana kekuasaan, mana rechtsstaat dan mana machtstaat, mana negara hukum dan mana negara tirani yang dilegitimasi secara hukum. Hukum yang seharusnya diberi muatan-muatan nilai-nilai kebenaran filosofis yang dideduksi dari asas-asas hukum oleh kekuasaan, pada kenyataanya diberi muatan kekuasaan itu sendiri yang harus dipandang sebagai kebenaran. Manipulasi kebenaran yang terjadi disini berakar penyesatan logika melalui permainan bahasa (language of the game bahwa hukum itu sama dengan undang-undang dalam aliran positivisme.   Kata Kunci: Hukum, Moral, dan Kekuasaan

Analisa Highest and Best Use Pada Lahan Kosong Di Jemur Gayungan II Surabaya

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Finda Virgitta Faradiany

2014-09-01

Full Text Available Perkembangan bisnis properti di Surabaya yang semakin pesat, mengakibatkan permintaan terhadap lahan semakin tinggi. Namun fakta di lapangan menampakkan hal yang sebaliknya karena ternyata masih terdapat lahan-lahan yang dibiarkan kosong tidak dimanfaatkan oleh pemiliknya. Kondisi yang demikian memerlukan efisiensi dan optimalisasi penggunaan lahan dengan mendirikan sebuah properti komersial yang memberikan keuntungan bagi pemilik serta lingkungan sekitarnya.Lahan “X” seluas 1786 m2 berlokasi di Jl. Jemur Gayungan II merupakan lahan kosong yang terletak di dekat daerah perkantoran dan berpotensi dikembangkan menjadi properti komersial. Penentuan nilai lahan “X” bergantung pada penggunaan lahan. Metode penilaian yang digunakan adalah analisa penggunaan tertinggi dan terbaik atau Highest and Best Use (HBU yang secara legal diijinkan, secara fisik memungkinkan, layak secara finansial dan memiliki produktifitas maksimum. Dari hasil penelitian didapatkan alternatif yang menghasilkan nilai lahan tertinggi dan produktivitas maksimum adalah hotel. Nilai lahan yang didapatkan sebesar Rp 9.722.718/m2 dengan produktivitas meningkat sebesar 486%.

Relasi Gramatikal BahasaMelayu Klasik dalam Hikajat ‘Abdullah

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Muhammad Yusdi

2012-11-01

Full Text Available Beberapa orang ahli linguistik telah mengkaji naskah Bahasa Melayu Klasik namun naskah BMK pada Hikajat ‘Abdullah yang berkenaan dengan Relasi Gramatikal belum pernah dilakukan hingga sekarang ini. Penelitian dan pembahasan tentang tipologi sintaksis BMK secara khusus belum menjadi perhatian para peneliti dan pengamat BMK dengan kerangka kerja sesuai dengan tipologi linguistik. Penelitian ini membahas perihal relasi gramatikal dengan kerangka kerja linguistis Adapun yang menjadi pokok bahasan dalam disertasi ini ialah “Bagaimana Relasi Gramatikal” saling berhubungan dalam BMK yang terdapat pada Hikajat ‘Abdullah. Selain dengan pembahasan yang dilandasi dengan teori tipologi linguistik, penelaahan data penelitian ini juga dilakukan dengan teori tata bahasa formal yaitu Tata bahasa Relasional (TR dan pembahasan ini juga melibatkan peran semantis yang tercakup pada sebuah bangunan sintaksis secara keseluruhan sehingga orang tidak kehilangan momentum dan masih menyadari bahwa bahasa adalah maujud hak milik umat manusia yang berartikulasi ganda, yaitu bentuk (bunyi di satu pihak dan arti (makna di pihak lain. Sasaran pembahasan ini dititik beratkan pada tataran sintaksis namun dengan tidak meninggalkan sama sekali keberterimaan semantis seperti yang disebutkan di atas tadi. Adapun di antara pokok persoalan yang dianalisis tersebut ialah masalah akusativitas, ergativitas, dan medialitas. Adapun tujuan utama penelitian ini ialah menganalisis dan membahas sifat-perilaku gramatikal yang pada gilirannya memperlihatkan peran semantis juga pada tataran sintaktis BMK HABAKM. Dengan demikian, dapatlah ditentukan relasi gramatikal dan peran semantis dari segi tipologi sintaksis BMK HABAKM ini.Setelah menelaah data yang ada pada BMK HABAKM secara tipolgis, dapat disimpulkan bahwa, secara sintaktis, BMK HABAKM memperlakukan S sama dengan A, dan perlakuan yang berbeda dikenakan pada P (S = A, ? P. Oleh karena itu, BMK HABAKM termasuk kelompok bahasa yang

Annual update of how each state stands on legislative issues affecting advanced nursing practice.

Science.gov (United States)

Pearson, L J

1996-01-01

The change from a free-for-service system to a system run by managed-care organizations has caused dramatic shifts in where and how health care is delivered. Within the managed-care systems, administrators need to show a good bottom line. Rapid restructuring of the system and the need for profit create many potential consequences (e.g., APNs squeezed out of participation on some provider panels; previously unattractive poor patients are now attractive because they can provide an ongoing revenue base; the use of more unlicensed personnel to provide patient services). Private businesses and the federal government like managed-care health care systems as an answer to the out-of-control escalating costs of health care. Managed care is likely to stay with us for a long while. Because political force comes from money and there is plenty of that in health care insurance corporations, managed care is likely to be with us for a long time. Regulations and control of these managed-care systems will probably be difficult. However, though big business has the money, APNs have the feet, hands and patience to seek further regulation of these huge corporations (e.g., antidiscrimination language to prevent exclusion from provider panels). With the reality of managed care, MDs are no longer in control of the health care system. The AMA's recent attempt to control other providers is tantamount to one ship officer attempting to control another on the Titanic's (i.e., fee-for-service system's) last evening. In a few states, fee-for-service is still predominant, but the majority of states are rapidly moving into megaconglomerate, finance-driven managed care run by business administrators. Things are getting so complex in today's world of corporate takeovers, managed-care megaconglomerates, and power-brokering politics that it is easy to understand why millions of Americans drown themselves in relatively simplistic good-versus-evil entertainment dramas. Huge changes in how the system

PENGARUH LOKASI SEKOLAH, PROMOSI SEKOLAH, PERSEPSI, DAN TEMAN SEBAYA TERHADAP MINAT SISWA MEMILIH JURUSAN

Directory of Open Access Journals (Sweden)

Martha Amelia Fadjrin

2017-06-01

Full Text Available Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh lokasi sekolah, promosi sekolah,persepsi, dan lingkungan teman sebaya terhadap minat siswa memilih jurusanAP di SMK Swasta Kota Semarang baik. Populasi dalam penelitian ini adalah siswa kelas Xjurusan AP di SMK Swasta Kota Semarang yang berjumlah 203siswa.Sampel yang digunakan adalah keseluruhan dari populasi. Metode pengumpulan data menggunakan kuesioner. Teknik analisis data menggunakan analisis regresi linier berganda, uji asumsi klasik, dan analisis deskriptif persentase. Hasil penelitian menunjukkan bahwa 1 Ada pengaruh positif dan signifikan lokasi sekolah, promosi sekolah, persepsi, dan lingkungan teman sebaya secara simultan terhadap minat siswa memilih jurusanAP sebesar76.7%. 2 Ada pengaruh positif dan signifikan lokasi sekolah secara parsial terhadap minat siswa memilih jurusansebesar 9,42%. 3 Ada pengaruh positif dan signifikan promosi sekolah secara parsial terhadap minat siswa memilihjurusan sebesar 11,56%. 4 Ada pengaruh positif dan signifikan persepsi secara parsial terhadap minat siswa memilih jurusan sebesar 16,7%.5 Ada pengaruh positif dan signifikan teman sebaya secara parsial terhadap minat siswa memilihjurusan sebesar 9,6%.Kesimpulan dari penelitian ini adalah ada pengaruh positif dan signifikan antara lokasi sekolah, promosi sekolah, persepsi, dan lingkungan teman sebaya terhadap minat siswa memilih jurusan AP di SMK Swasta Kota Semarang baik secara partial maupun secara simultan. This research aimed to find out and anlayze the influences of school location, school promotion, perception and environtment of students’ peer onstudents’ interest in choosing office administration study program at Private Vocational High Schools in Semarang.The population in this study was all students office administration subject in private vocational high school in Semarang, which were 203students in total number. The sample was the whole population The method of data

Maximum credible earthquake (MCE) magnitude of structures affecting the Ujung Lemahabang site

International Nuclear Information System (INIS)

Soerjodibroto, M.

1997-01-01

This report analyse the geological structures in/around Muria Peninsula that might originating potential earthquake hazard toward the selected site for NPP, Ujung Lemahabang (ULA). Analysis was focused on the Lasem fault and AF-1/AF-4 offshore faults that are considered as the determinant structures affecting the seismicity of ULA (Nira, 1979, Newjec, 1994). Methods for estimating the MCE of the structures include maximum historical earthquake, and relationship between the length of the fault and the magnitude of earthquake originating from the known structure (Tocher, Iida, Matsuda, Wells and Coopersmith). The MCE magnitude estimating by these method for earthquake originating along the Lasem and AF-1/AF-4 faults vary from 2,1M to 7,0M. Comparison between the result of historical data and fault-magnitude relationship, however, suggest a MCE magnitude of Ms=7,0M for both fault zones. (author)

Environmental conditioning on uranium surface distribution in the tropical region; Condicionantes ambientais sobre a distribuicao superficial de uranio numa regiao de climatologia tropical

Energy Technology Data Exchange (ETDEWEB)

Silva, Heitor Evangelista da; Licinio, Marcus V.S.; Miranda, Marcio R. [Universidade do Estado, Rio de Janeiro, RJ (Brazil). Lab. de Ciencias Radiologicas

2001-07-01

Based on a high resolution aerogammaspectrometer survey over the State of Rio de Janeiro, it is presented an associative study of equivalent uranium concentration and environmental parameters. The aspects considered in this study included geological domains like Sandys, Gnaisses, Granites, Xists; soils domains like Organic and Alluvial ones, Litolic, Glei, Podzolic, Red-yellow, Latossolo, Planossolo, Red bruizem, Cambissolo, Hidromorphic Podzol, Yellow latossolo; geomorphology (Coast Plains and River Accumulation Land, Coast Tabulators, Pomba-Muriae Rivers Spread Depression, Northern Mantiqueira, main Hills and Coastal Rock Massifs, Steep slopes and Reverses of Serra do Mar Mountain Range ,Serra dos Orgaos Mountain Range and Bocaina Tablelands), Paraiba do Sul Crests Alignment, Medium Paraiba do Sul Depression); influence of mean annual rain intensity and hydrographical categories were also evaluated. Geoprocessing of each environmental data base at the same cartographical base of uranium surface distribution was the basic methodology employed. (author)

Maximum credible earthquake (MCE) magnitude of structures affecting the Ujung Lemahabang site

Energy Technology Data Exchange (ETDEWEB)

Soerjodibroto, M [National Atomic Energy Agency, Jakarta (Indonesia)

1997-03-01

This report analyse the geological structures in/around Muria Peninsula that might originating potential earthquake hazard toward the selected site for NPP, Ujung Lemahabang (ULA). Analysis was focused on the Lasem fault and AF-1/AF-4 offshore faults that are considered as the determinant structures affecting the seismicity of ULA (Nira, 1979, Newjec, 1994). Methods for estimating the MCE of the structures include maximum historical earthquake, and relationship between the length of the fault and the magnitude of earthquake originating from the known structure (Tocher, Iida, Matsuda, Wells and Coopersmith). The MCE magnitude estimating by these method for earthquake originating along the Lasem and AF-1/AF-4 faults vary from 2,1M to 7,0M. Comparison between the result of historical data and fault-magnitude relationship, however, suggest a MCE magnitude of Ms=7,0M for both fault zones. (author)

Environmental conditioning on uranium surface distribution in the tropical region

International Nuclear Information System (INIS)

Silva, Heitor Evangelista da; Licinio, Marcus V.S.; Miranda, Marcio R.

2001-01-01

Based on a high resolution aerogammaspectrometer survey over the State of Rio de Janeiro, it is presented an associative study of equivalent uranium concentration and environmental parameters. The aspects considered in this study included geological domains like Sandys, Gnaisses, Granites, Xists; soils domains like Organic and Alluvial ones, Litolic, Glei, Podzolic, Red-yellow, Latossolo, Planossolo, Red bruizem, Cambissolo, Hidromorphic Podzol, Yellow latossolo; geomorphology (Coast Plains and River Accumulation Land, Coast Tabulators, Pomba-Muriae Rivers Spread Depression, Northern Mantiqueira, main Hills and Coastal Rock Massifs, Steep slopes and Reverses of Serra do Mar Mountain Range ,Serra dos Orgaos Mountain Range and Bocaina Tablelands), Paraiba do Sul Crests Alignment, Medium Paraiba do Sul Depression); influence of mean annual rain intensity and hydrographical categories were also evaluated. Geoprocessing of each environmental data base at the same cartographical base of uranium surface distribution was the basic methodology employed. (author)

Investigation on seismic characteristic in Muria Peninsula to asses the NPP seismic design

International Nuclear Information System (INIS)

Kusnowo, A.

1997-01-01

A feasibility study on first nuclear power plant was conducted during 4,5 years started on 22 November 1991. This study consists of two parts. First, the non site study, Second part is the site and environmental study. The scope of non site studies are economic financing, technical and safety aspect as well as fuel cycle and waste management aspect. The site and environmental studied consist of site conditions and qualification, seismological, environmental condition as well as social economic and cultural impact. In the first step of site study (step 1), the result come up to the three candidates named Ujung Lemahabang, Ujung Watu and Ujung Grenggengan. Further study on geology, topography, oceanography, geophysics, hydrology, seismology, vulcanology, man induced event, etc was done on those three candidates (named as step 2). The results come up with Ujung Lemahabang as the best candidates. It is important to know basic, characteristic of seismicity of nuclear power plant sitting region for seismic hazard assessment this was done as step 3. This paper describe the results of step 3. (J.P.N.)

Measurement Testing of Radon Gas for Fault Activity Detection in Rahtawu Muria, Pati

International Nuclear Information System (INIS)

Suntoko, Hadi; Hamzah, Imam

2004-01-01

The radon surface can be used to investigates not only for environment but also to be develop in an earth application. The investigation is carried out at the Rahtawu fault, that includes, to the Pati regency which is located 40 km South of ULA. The objective of study to measure the radon released from the fracture zone activities. RDA equipment is being used to measure the radon gas released. The result shown that the high value of radon is 311 cpm with the background of 18 cpm, whereas the low value falls at 0 cpm. The tattoo value are influenced by the soil condition, tattoo time, hardness, weather, soil/stone porosity and fault possession. (author)

Investigation on seismic characteristic in Muria Peninsula to asses the NPP seismic design

Energy Technology Data Exchange (ETDEWEB)

Kusnowo, A [National Atomic Energy Agency, Jakarta (Indonesia)

1997-03-01

A feasibility study on first nuclear power plant was conducted during 4,5 years started on 22 November 1991. This study consists of two parts. First, the non site study, Second part is the site and environmental study. The scope of non site studies are economic financing, technical and safety aspect as well as fuel cycle and waste management aspect. The site and environmental studied consist of site conditions and qualification, seismological, environmental condition as well as social economic and cultural impact. In the first step of site study (step 1), the result come up to the three candidates named Ujung Lemahabang, Ujung Watu and Ujung Grenggengan. Further study on geology, topography, oceanography, geophysics, hydrology, seismology, vulcanology, man induced event, etc was done on those three candidates (named as step 2). The results come up with Ujung Lemahabang as the best candidates. It is important to know basic, characteristic of seismicity of nuclear power plant sitting region for seismic hazard assessment this was done as step 3. This paper describe the results of step 3. (J.P.N.)

ANGIOFIBROMA NASOFARING PADA PASIEN USIA LANJUT

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Sony Yudianto A

2014-09-01

Full Text Available Angiofibroma nasofaring adalah tumor jinak nasofaring yang secara histopatologis merupakan tumor jinak, tetapi secara klinis bersifat destruktif. Tumor ini sering terjadi pada laki-laki prepubertas dan remaja, jarang ditemukan pada pasien usia di atas 25 tahun. Pada kasus ini dilaporkan angiofibroma nasofaring pada laki-laki usia lanjut dengan keluhan hidung tersumbat dan epistaksis berulang, dilakukan operasi ekstirpasi tumor dengan pendekatan transpalatal. Prognosis pasien ini baik, karena pada evaluasi 3 bulan setelah operasi tidak tampak pertumbuhan tumor baru.[MEDICINA 2013;44:105-108].

STRATEGI PENGELOLAAN ZAKAT DALAM PENGENTASAN KEMISKINAN

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Irsyad Andriyanto

2011-06-01

Dalam Islam upara pengatasan kemiskinan adalah dengan zakat. Oleh karena itu, zakat seharusnya dikelola secara produktif dan profesional sehingga zakat dapat mengambil bagian dalam merealisasikan ide-ide Islam untuk mensejahterakan masyarakat Saah satu lembaga yang terbukti telah mampu mengelola zakat secara terpercaya, transparan, dan profesional adalah Rumah Zakat Indonesia (RZI. Kajian ini menggunakan pendekatan sosial-ekonomi, Analisis yang yang digunakan bertujuan untuk mempermudah data ke dalam bentuk yang lebih mudah untuk dibaca dan diinterpretasikan. Analisis yang digunakan dalam kajian ini adalah analisis deskriptif.

Measurement of Quality to Improve Care in Sleep Medicine

OpenAIRE

Morgenthaler, Timothy I.; Aronsky, Amy J.; Carden, Kelly A.; Chervin, Ronald D.; Thomas, Sherene M.; Watson, Nathaniel F.

2015-01-01

The Board of Directors of the American Academy of Sleep Medicine (AASM) commissioned a Task Force to develop quality measures as part of its strategic plan to promote high quality patient-centered care. Among many potential dimensions of quality, the AASM requested Workgroups to develop outcome and process measures to aid in evaluating the quality of care of five common sleep disorders: restless legs syndrome, insomnia, narcolepsy, obstructive sleep apnea in adults, and obstructive sleep apne...

Lirik Musikal pada Lagu Anak Berbahasa Indonesia

Directory of Open Access Journals (Sweden)

Fortunata Tyasrinestu

2014-12-01

Full Text Available Penelitian ini mengkaji bahasa lagu anak berbahasa Indonesia. Lagu anak berbahasa Indonesia adalah lagu yang diperuntukkan dan dinyanyikan oleh anak-anak sesuai dengan perkembangan anak. Tujuan penelitian ini adalah untuk mendeskripsikan karakteristik lagu anak (LA secara musikal dengan memperhatikan kata-kata atau lirik yang ada dalam lagu anak berbahasa Indonesia. Karakteristik lirik dan karakteristik musikal yang saling menyatu merupakan harmoni yang indah dalam lagu anak. Penelitian ini menggunakan metode deskriptif. Analisis yang diterapkan adalah metode holistik yang dipergunakan untuk melihat LA dari beberapa perspektif melalui wawancara dan angket yang diperoleh dari praktisi musik dan praktisi pendidikan, guru, orangtua, siswa dan awam. Hasil penelitian menunjukkan bahwa lagu anak berbahasa Indonesia mempunyai beberapa karakteristik secara lirik dan musikal yaitu 1 pola ritme yang diulang secara musikal, 2 melodi yang diulang secara musikal, 3 motif yang diulang secara musikal, dan 4 kata-kata yang diulang secara musikal. Fungsi lagu anak berbahasa Indonesia selain untuk belajar bahasa juga mengandung nilai pendidikan dan karakter positif untuk anak dengan kata-kata bermakna positif pada lirik-liriknya.   The Characteristics of Musical Lyrics on Indonesian Children Songs.The study tries to examine the discourse of Indonesian children songs. Indonesian children songs are songs that are composed for and sung by children in accordance with the child development stages. The purpose of this study is to describe the discourse of Indonesian children songs which describe their musical characteristics by giving more attention on words or lyrics of the songs. The characteristics of lyrics and musical characteristics that belong to each other are mainly a beautiful harmony in children songs. This study uses a descriptive method. The holistic method is employed to analyze children songs from some perspectives by doing the interview and

PENGARUH PENERAPAN PERAN TOTAL QUALITY MANAGEMENT TERHADAP KUALITAS SUMBERDAYA MANUSIA

Directory of Open Access Journals (Sweden)

R. Andi Sularso

2004-01-01

Full Text Available Some ways have been conducted to improve the quality of the human resources. One of them is to apply TQM. The data used in this experiment was primary data obtained from the respondents. Coefficient of determination was used to examine the model fit. t-test had been used to examine the hyphoteses partially and F-test had been used to examine hypotheses secara simultaneously. The result showed that the role of employee, role of leader, relation between leader and emplyoee, aspect of organization and aspect of environment were among variables that have a siqnificantly influence on the improvement of (1 theoretical ability; (2 technical ability; (3 conceptual ability; (4 moral ability; (5 technical skill (6 the quality of human resources. Abstract in Bahasa Indonesia : Telah banyak cara dilakukan untuk meningkatkan kualitas sumberdaya manusia tersebut, salah satunya adalah melalui penerapan TQM. Data yang digunakan dalam penelitian ini adalah data primer yang diperoleh langsung dari responden. Untuk mengetahui ketepatan model yang digunakan, diuji dengan koefisien determinasi, pengujian Hipotesis secara parsial digunakan uji t dan pembuktian hipotesis secara bersama-sama digunakan uji F. Berdasarkan pada analisis data diperoleh hasil sebagai berikut : variabel peran karyawan, variabel peran pimpinan, variabel hubungan pimpinan dan karyawan, variabel aspek organisasi dan variabel aspek lingkungan berpengaruh secara nyata terhadap peningkatan (1 kemampuan teoritis; (2 kemampuan teknis; (3 kemampuan konseptual; (4 kemampuan moral; (5 ketrampilan teknis; (6 kualitas sumberdaya manusia. Kata kunci: Total Quality Management (TQM,Kualitas Sumber Daya Manusia (SDM.

Ibn Khaldūn’s Social Thought on Bedouin and Ḥaḍar

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Moh. Pribadi

2014-12-01

[Melalui kerangka teori sosiologi modern serta metode penafsiran teks secara historis-sosiologis, penelitian ini berusaha untuk menjelaskan pemikiran sosial Ibn Khaldun tentang masyarakat badui dan ḥaḍar. Ide Ibnu Khaldun tentang masyarakat dapat dilihat pada konsepnya mengenai dua masyarakat ini beserta solidaritas sosial mereka, dengan karakteristik masing-masing. Masyarakat nomaden yang identik dengan masyarakat badui memiliki struktur sosial dan spesifisitas dengan kecenderungan pada kebajikan, ramah, dan keseragaman; sementara masyarakat ḥaḍar memiliki struktur dan kekhasan sosial seperti pluralis, pragmatis, dan hedonis. Dalam hal gaya hidup, masyarakat badui tampak lebih dinamis daripada ḥaḍar. Cara hidup masyarakat badui ditandai dengan terus berpindah dari satu tempat ke tempat lain, dan ini membuat komunitas ini cerdas dalam merumuskan visi, misi, program, dan sasaran yang ingin dicapai dalam hidup. Spesifisitas badui tercermin dalam kesiap-siagaan mereka, satu hal yang tidak terlihat dalam komunitas ḥaḍar. Sementara itu, dengan kemakmuranya, orang ḥaḍar sibuk dengan aktivitas perkotaan dan pembangunan masyarakat sipil. Ibn Khaldun telah berusaha untuk memahami manusia dan keberadaannya secara individu ataupun sosial melalui ‘ilm al-‘umrān. Metodologi sosialnya mencerminkan pandangannya secara keseluruhan melalui pengamatan realitas sosial secara komprehensif. Penulis berpendapat bahwa metodologi sosial Ibn Khaldun yang menggabungkan data dan fakta sosial dengan agama bisa menjadi referensi dan contoh pendekatan yang komprehensif. Ide penting Ibnu Khaldun lainnya adalah tentang perkembangan kecerdasan masyarakat yang meliputi tiga tahap: tamyīzī, tajrībī, dan naẓārī.

CARA PENETAPAN BATAS ZEE ANTARA INDONESIA DAN MALAYSIA DI SELAT MALAKA DENGAN MEDIAN LINE

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Ansori

2012-11-01

Full Text Available Penelitian ini secara menyeluruh mempunyai tujuan untuk memperjelas batas-batas ZEE antara Indonesia dengan Malaysia di selat Malaka, dan sebagai masukan serta informasi kepada masyarakat dan instansi-instansi penegakan hukum di laut agar lebih memahami tentang batas-batas ZEE dengan Negara Malaysia terutama di selat Malaka. Metode pendekatan masalah yang dipakai dalam penulisan penelitian ini dilakukan secara Yuridis Normatif, yaitu menitikberatkan pada peraturan perundangundangan yang berlaku sebagai dasar pembahasan serta kaitannya dengan penerapannya dalam praktek. Kesimpulan dari penelitian ini adalah Indonesia harus mengkaji ulang hasil perjanjian landas kontinen tahun 1969 dengan melakukan rekonstruksi penetapan garis batas ZEE Indonesia dengan Malaysia di Selat Malaka, karena penetapan batas tersebut menggunakan titik – titik dasar dan garis dasar pada air rendah (kontur no. l di pantai Timur Sumatera seperti tercantum dalam UU. No : 4 / Prp. Tahun 1960, sedangkan Malaysia menarik garis dasar dari Pulau Jarak ke Pulau Perak sejauh 123 nm, ini tidak sesuai dengan ketentuan dalam UNCLOS’ 82 dimana pada Pasal 47 ayat (2 hanya membolehkan maksimal 100 nm. Garis batas ZEE yang dihasilkan dari rekonstruksi penetapan di atas mempunyai cakupan perairan yang lebih luas dibandingkan cakupan perairan hasil perjanjian batas landas kontinen tahun 1969. Apabila konsep penetapan batas ZEE di Selat Malaka dihitung luasnya mulai dari garis dasar (baseline sampai ke garis batas ZEE, maka Indonesia memperoleh cakupan perairan sebesar 36.700 km2. Hal ini tentunya akan memberikan keuntungan yang besar baik secara ekonomis maupun secara kedaulatan.

PENGARUH QUALITY OF WORK LIFE (QWL TERHADAP KINERJA PEGAWAI DENGAN DISIPLIN DAN KEPUASAN KERJA SEBAGAI VARIABEL INTERVENING

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Titik Nurbiyati

2016-01-01

Full Text Available Penelitian ini dimaksudkan untuk mengetahui pengaruh antara variable Quality of Work Life (QWL terhadap kinerja karyawan dengan disiplin dan kepuasan kerja sebagai variabel intervening. Data dalam riset ini menggunakan data primer dengan menggunakan alat analisis regresi dan analisis path. Dari analisis data diperoleh hasil secara parsial QWL berpengaruh signifikan terhadap kepuasan kerja dan kinerja pegawai namun tidak berpengaruh terhadap disiplin kerja. Secara simultan QWL, disiplin kerja dan kepuasan kerja secara bersama-sama berpengaruh signifikan terhadap kinerja pegawai. Selain itu ada pengaruh tidak langsung (QWL terhadap kinerja melalui disiplin kerja lebih kecil dibandingkan pengaruh langsung terhadap kinerja. Kemudian ada pengaruh tidak langsung (QWL terhadap kinerja melalui kepuasan kerja lebih besar dibandingkan pengaruh langsung (QWL terhadap kinerja. Nilai R Square sebesar 0,553 yang artinya variabel QWL, kepuasan kerja dan disiplin kerja mempengaruhi kinerja hanya sebesar 55,30 % sedangkan 44,7% dipengaruhi faktor lain. Rekomendasi dari hasil riset ini variabel QWL kategori pertumbuhan dan perkembangan perlu adanya program Training Need Analysis (TNA guna memenuhi kebutuhan tenaga kependidikan yang sesuai dengan kebutuhan pekerjaan. Sedangkan variabel QWL kategori kompensasi perlu mengadakan salary survey terhadap perguruan tinggi yang dipilih secara sampling yang bertujuan untuk melakukan perbandingan data mengenai kebijakan, praktek dan metode penggajian. Perlu dilakukan riset lanjutan untuk mengetahui faktor yang berpengaruh terhadap kinerja selain faktor QWL, disiplin kerja dan kepuasan kerja.Kata Kunci: Quality of Work Life (QWL, Disiplin Kerja, Kepuasan kerja dan Kinerja Karyawan

TOKSISITAS PROTEIN 89 kDa PRODUK EKSTRASELULER Streptococcus agalactiae PADA IKAN NILA (Oreochromis niloticus

Directory of Open Access Journals (Sweden)

Amrullah Amrullah

2015-09-01

Full Text Available Identifikasi protein toksin yang bersifat antigenik dari produk ekstraselular (ECP crude Streptococcus agalactiae penting dilakukan untuk pengembangan vaksin protein toksoid. Penelitian ini bertujuan untuk mengevaluasi toksisitas protein dengan berat molekul 89 kDa dari ECP Streptococcus agalactiae hasil fraksinasi dengan SDS-PAGE (ECPP89. Ikan nila dengan bobot sekitar 25 g masing-masing diinjeksi secara intraperitonial dengan protein ECPP89 dosis 1, 2, 4, 8, dan 16 μg/mL/ekor ikan (secara berturut-turut diberi kode ECPP89-1, ECPP89-2, ECPP89-4, ECPP89-8, dan ECPP89-16. Sebagai kontrol positif ikan diinjeksi dengan bakteri utuh S. agalactiae 1 x 104 cfu/mL (WCB dan ECP crude S. agalactiae (ECPC, sementara kontrol negatif ikan diinjeksi larutan PBS. Ikan dipelihara selama 15 hari dengan kepadatan 10 ekor (70 L air. Hasil penelitian menunjukkan bahwa ikan nila yang diinjeksi dengan ECPP89 mengalami gejala seperti perubahan morfologi, perubahan nafsu makan, dan perubahan renang ikan. Mortalitas pada perlakuan ECPP89 secara umum lebih tinggi dibandingkan dengan ECPC, namun lebih rendah (p<0,05 dibandingkan dengan WCB. Mortalitas ikan pada perlakuan ECPP89-4, ECPP89-8, dan ECPP89-16 tidak berbeda tetapi secara signifikan lebih tinggi dibandingkan dengan ECPC dan dua dosis perlakuan ECPP89 lainnya (p<0,05. Ikan kontrol negatif tidak mengalami kematian maupun perubahan klinis. Hasil ini menunjukkan bahwa ECPP89 merupakan protein toksin dari ECP S. agalactiae.

Faktor-Faktor yang Mempengaruhi Penghimpunan Dana Pihak Ketiga Perbankan Syariah di Indonesia

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Bambang Prasetya

2015-12-01

Full Text Available Abstract. This study aims to determine the development of third-party funds of Islamic Banking in Indonesia. This study uses time series data Q1 2008 to Q4 2012. The analysis tool used is multiple regression. Based on the survey results revealed that conventional banking interest rate (r, the equivalent rate (ER, Economic Growth (PE and Growth Outlet (PO are jointly very significant effect on Islamic Banking Deposits While partially known that  conventional banking interest rate (r significantly affects deposits, equivalent rate (ER was not statistically significant effect, Economic Growth (PE no statistically significant effect and Growth Outlet (PO statistically significant effect on Deposits Islamic Banking. Keywords:interest rate, outlet, equivalent rate Abstrak Penelitian ini bertujuan untuk mengetahui perkembangan penghimpunan Dana Pihak Ketiga (DPK Perbankan Syariah di Indonesia. Penelitian ini menggunakan data time series triwulan 1 tahun 2008 sampai dengan triwulan 4 tahun 2012. Alat analisis yang digunakan adalah regresi berganda. Berdasarkan hasil analisis diketahui bahwa Suku Bunga perbankan konvensional (r, Equivalen rate (ER, Pertumbuhan Ekonomi (PE dan Pertumbuhan Outlet (POsecara bersama-sama berpengaruh sangat nyata terhadap DPK Perbankan Syariah. Sementara secara parsial diketahui bahwa Suku bunga Perbankan konvensional (r berpengaruh signifikan terhadap DPK, Equivalen rate (ER tidak berpengaruh signifikan secara statistik, Pertumbuhan Ekonomi (PE tidak berpengaruh signifikan secara statistik dan Pertumbuhan Outlet (PO berpengaruh signifikan secara statistik terhadap DPK Perbankan Syariah. Kata Kunci: tingkat bunga, outlet, equivalent rate

PENGARUH KUALITAS LAYANAN SMS BANKING TERHADAP LOYALITAS NASABAH PT BANK RAKYAT INDONESIA KANTOR CABANG MADIUN

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Agus Yan Praptasany

2015-04-01

Full Text Available Loyalitas nasabah adalah puncak pencapaian pelaku bisnis perbankan. Nasabah yang puas dan setia tidak akan ragu untuk menjadi penyebar kabar baik yang selalu menyebarkan kebaikan mengenai produk perbankan yang di gunakannya. Penelitian ini bertujuan untuk menguji pengaruh kualitas layanan yang terdiri dari bukti fisik, kehandalan, daya tanggap, jaminan dan empati secara parsial dan simultan  terhadap loyalitas nasabah PT Bank Rakyat Indonesia kantor cabang Madiun. Populasi penelitian ini adalah nasabah yang menggunakan SMS Banking di PT Bank Rakyat Indonesia kantor cabang Madiun. Sampel perbankan dalam penelitian ini adalah nasabah selama periode awal tahun 2013 sampai dengan bulan Maret 2014. Pengambilan sampel dilaksanakan dengan teknik Indidental Sampling sehingga didapat sampel sejumlah 377 responden. Pengumpulan data pada penelitian ini didapat dengan wawancara dan kuisioner.  Metode analisis yang digunakan dalam penelitian ini adalah Analisis Regresi Linear Berganda. Dari hasil uji parsial yang telah dilakukan didapatkan hasil bahwa bukti fisik, daya tanggap, kehandalan, jaminan dan empati  berpengaruh  secara parsial terhadap loyalitas nasabah PT Bank Rakyat Indonesia Cabang Madiun. Hal ini dikarenakan kelengkapan fisik ruang kantor, kecepatan, ketepatan, keamanan, kemudahan bertransaksi dengan SMS Banking mempengaruhi loyalitas nasabah Bank Rakyat Indonesia Cabang Madiun. Dari hasil uji simultan diperoleh hasil bahwa kualitas layanan yang terdiri dari bukti fisik, daya tanggap, kehandalan, jaminan dan empati secara simultan berpengaruh terhadap loyalitas nasabah PT Bank Rakyat Indonesia kantor cabang Madiun. Hal ini menunjukkan apabila Dimensi kualitas layanan dilaksanakan secara bersama – sama akan membuat nasabah semakin Loyal.

Analisa dan Perancangan Sistem Informasi Penjualan Online (E-Commerce pada CV Selaras Batik Menggunakan Analisis Deskriptif

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Himawan -

2015-05-01

Full Text Available Batik merupakan salah satu pakaian tradisional yang menjadi ciri khas dan kebanggaan bagi bangsa Indonesia, dimana batik juga telah dikenal secara luas baik dalam skala nasional dan internasional. Peluang dalam kegiatan bisnis penjualan batik yang meningkat beberapa waktu ini dilihat oleh banyak pihak sebagai prospek yang menjanjikan. Penjualan batik secara umum di beberapa wilayah di Indonesia masih dilakukan dengan cara yang sederhana dan klasik. Untuk dapat menjangkau lebih banyak pelanggan serta memperluas area pemasaran sekaligus promosi batik, maka diperlukan media yang dapat menunjang kegiatan promosi, transaksi penjualan dan informasi batik dengan optimal. Salah satu media yang menjadi perhatian masyarakat sekarang ini adalah dengan menggunakan media website online. E-Commerce merupakan salah satu kegiatan transaksi bisnis baik barang dan jasa yang dilakukan secara elektronik dengan menggunakan jaringan internet CV Selaras Batik menyadari bahwa peranan media website dapat digunakan untuk meningkatkan omset penjualan dan juga sebagai media sarana dalam memasarkan produk batik yang mereka miliki untuk menjangkau pasar yang lebih luas lagi serta dapat meminimalkan biaya-biaya operasional seperti biaya iklan dan juga biaya sewa toko secara fisik. Penulisan paper ini bertujuan untuk menganalisa pengaruh dari penggunaan media website online dalam hal ini adalah e-commerce dengan menggunakan pendekatan B2C (Business-to- Customer dalam upaya meningkatkan transaksi penjualan batik pada CV Selaras Batik dan juga media penyampaian informasi baik pada para pelanggan dan masyarakat umum dalam memperoleh informasi mengenai produk-produk batik yang dipasarkan oleh CV Selaras Batik. 

PELATIHAN PEMECAHAN MASALAH SECARA KREATIF UNTUK MENINGKATKAN KINERJA WIRANIAGA

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Listya Istiningtyas

2016-05-01

Full Text Available Sales people often experience obstacle in marketing, it’s because they disable to face troubles that appear. Salespeople need creative problem solving ability to do their job. The main purpose of this research is to examine the effectiveness of creative problem solving training to increase job performance. This research use quasi experimental approach with the untreated control group design with pretest and posttest plan. Creative problem solving training is given to the experimental group and the control group did not receive this training. The subjects are salespeople of dealer motorcycle who face consumer directly. The subject is divided into experimental group (18 subject, middle area and control group (18 subject, south area. Job performance form is made by researcher and company party to appraise job performance. The result of the data were analyzed by mixed anova with statistic programe SPSS 15.0 for Windows. The result showed that creative problem solving training can significant increase job performance in experimental group (F = 13,387; p < 0,01. The experimental group showed higher job performance than the control group. This research goes to show that Creative problem solving training contributes 28,3 % in increasing the level of job performance.

Latihan Keterampilan Intelektual dan Kemampuan Pemecahan Masalah Secara Kreatif

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Deetje Josephine Solang

2016-02-01

Full Text Available The study tries to investigate the utilization of intellectual creative skills within the framework of the triarchic theory of intelligence in reading activities. The subject in which the theory was applied was Bahasa Indonesia (Indonesian. This experimental study involved randomly selected seventh graders of Junior High School. There were three hypotheses to test in the study. First, the order of the three types of intellectual skills suggested in the triarchic theory of intelligence presented during training as well as during instruction has effects on students' performance in attempting creative solution to problems derived from reading texts in the subject of Bahasa Indonesia. Multiple comparisons were employed to test this hypothesis. Second, there is a significant difference in creative problem solving performances between the experimental and the control groups. Analysis of variance was carried out to test this hypothesis. Third, scholastic aptitude has a role in predicting the creative problem solving performance. ANACOVA was employed to test this hypothesis. The results show that the students show the best performance when they are trained using the thinking order of practice-synthesis-analysis.

Modifikasi Blade Pencampur Pada Alat Pencampur Bahan Secara Mekanis

OpenAIRE

Nasution, Budiman Syahputra

2011-01-01

The agriculture equipment and machine has been operated since long time ago and their development were keep in touch with the development of human culture. Mixing is the distribution of one component to another. The mechanical mixing equipment has been designed to help the proses of mixing . The blade modification increase the capacity of mixing equipment and make the flow of material easier. The capacity of the equipment was 31,6 kg/hour, the percentage of imperfect mixing material was ...

Kajian Peran Waduk Sebagai Pengendali Kualitas Air Secara Alami

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Agung B. Supangat

2016-08-01

Full Text Available In Indonesia it was identified that there were much of polluted stream flow which cause improper consumed water. One of the rivers which has low of water qualities is Citarum River, West Java. However, along the Citarum river, there were built three reservoir dams (Saguling, Cirata and Jatiluhur that can control the condition of river water regime. Research was conducted in Citarum watershed to determine the role of those reservoirs on water quality control. Seven stations along the river were selected as observation posts of water samples. Based on the observation results it was indicated that water pollutants within Citarum river was very high. However, those pollutants could be purified or reduced by those reservoirs, hence water discharge from the reservoirs has better quality. In the future, deposition of those pollutants within the dam may has negative environment impact. Therefore, to sustain that function of the dam, comprehensive efforts on reducing pollutants from the catchment area is urgently required.

TEKNOLOGI PEMELIHARAAN LARVA KERAPU SUNU (Plectropomus leopardus SECARA MASSAL

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Titiek Aslianti

2016-12-01

Seed production technology of leopard coral trout, Plectropomus leopardus by improving hatchery management had been conducted in order to increase survival rate and to produce seed continuity. The initial feeding can successfully support in larval rearing. Feed organism as rotifer, trochophore gonad, egg yolk emulsion, and artificial feed emulsion, had been used as an initial feed. The twelve of concrete tanks with 6 m3 capacity were stocked with coral trout eggs at density 100,000—150,000 eggs/tank. Artemia nauplii, artificial feed, and mysid as feed, start on larvae D20 up to juvenile stage (D45. Growth rate and survival rate were observed and calculated when the experiment was terminated. The data was analyzed by descriptive. Nutrition value of food was analyzed by proximate and fatty acid composition. The others parameters such as deformity and water quality were observed. The result showed that artificial feed emulsion and egg yolk emulsion as an initial feeding can be improve the growth rate and increase survival rate of larvae. The range of total length, body weight and survival rate of the seed i.e. 1.95—2.85 cm; 0.64—0.73 g, and 0.25%— 3.97% with the daily growth rate 3,9%—4,22%, respectively. No back bone deformity in the seed, that is 21—23 segments with interspaces of segments 0.030—0.036 mm.

PEMBUATAN PUPUK FOSFAT DARI BATUAN FOSFAT ALAM SECARA ACIDULASI

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Faleh Setia Budi

2012-02-01

Full Text Available Phosphate rock containing P2O5 can be used as raw material of phosphate fertilizer. Phosphate rock canbe found in many areas in Indonesia, but its P2O5-content is relative low. In this research, phosphate rockfrom Rembang (P2O5-content 11.37% is used as raw material for phosphate fertilizer production byacidulation process using phosphoric acid solution. Operation variables are phosphoric acid concentration(10, 20, 30, 40 %-vol, spraying model of phosphoric acid solution (one hole and many holes, andspraying position of phosphoric acid solution (end, centre, end & centre. The result shows that theincrease of phosphoric acid concentration is proportional to P2O5-content in phosphate fertilizer withhighest P2O5-content in the amount of 18.29%. One-hole spraying model and end-position spraying giveshighest phosphate fertilizer yield in amount of 169.5 grams.