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Sample records for muria secara apn

  1. SPIRITUALITAS MURIA: AKOMODASI TRADISI DAN WISATA

    Directory of Open Access Journals (Sweden)

    Ahmad Falah

    2012-12-01

    Tradisi “nyekar” sangat dikenal oleh orang Jawa, khususnya di makam Muria Kudus Jawa Tengah. Penelitian ini mengungkap bahwa kebanyakan peziarah makam ini bertujuan untuk mendapatkan keberkahan (tabarrukan, keamanan dan kemudahan dalam hidup, menguasai ilmu linuwih, disembuhkan dari penyakit, dan mengharapkan kebaikan dari nenek moyang. Kunjungan mereka ke makam itu memberikan dampak yang besar bagi kehidupan masyarakat, baik secara ekonomi maupun sosial. Dalam perspektif ekonomi, lebih dari 1.500 tenaga kerja tergantung pada keberadaan makam Muria. Dampak yang lain adalah slidaritas setempat, kompetisi sosial, dan kesempatan kerja yang mengakibatkan munculnya tumbuhnya pragmatisme di kalangan anggota masyarakat Muria.

  2. Assessment of Muria geochemistry evolution and related to volcanic hazard to NPP site at Muria

    International Nuclear Information System (INIS)

    Basuki Wibowo; June Mellawati; Heni Susiati

    2011-01-01

    Study of geochemistry evolution aspect in Mt. Muria cycle to predict the level of volcanic hazards posed in the future on Muria nuclear power plant site was conducted. The purpose of the study was to determine the Muria geochemistry condition, tectonic patterns and to predict the level of volcanic hazard in the future on Muria nuclear power plant sites. The methodology used is the collection of secondary data on the complex geochemical conditions Muria volcanic in their life cycle, perform correlation geochemical cycle in its path towards conditions that most likely experienced tectonic, volcanic, and interpretation of the hazard posed. The study shows that geochemical conditions in Muria Volcano complex composed of potassium, low-yield product predicted high-temperature molten magma (decompression) and high potassium levels (compression). Pattern of tectonic decompression geochemical conditions associated with low potassium in Muria old, while the pattern of tectonic compression geochemical conditions associated with high potassium in young Muria. The level of volcanic hazard in the future indicated by the nature of non capable of Mt. Muria. (author)

  3. Constructing new APN functions from known ones

    DEFF Research Database (Denmark)

    Budaghyan, L.; Carlet, C.; Leander, Gregor

    2009-01-01

    We present a method for constructing new quadratic APN functions from known ones. Applying this method to the Gold power functions we construct an APN function x(3) + tr(x(9)) over F2(n). It is proven that for n >= 7 this function is CCZ-inequivalent to the Gold functions, and in the case n = 7...

  4. Gunung api maar di Semenanjung Muria

    Directory of Open Access Journals (Sweden)

    Sutikno Bronto

    2014-06-01

    Full Text Available http://dx.doi.org/10.17014/ijog.vol2no1.20074Three maars are well identifi ed in the Muria Peninsula, i.e. Bambang Maar, Gunungrowo Maar, and Gembong Maar. The maars were formed by monogenetic volcanic eruptions due to the interaction between heat source (magma, groundwater and calcareous basement rocks. This interaction is able to produce very high pressure of gas and steam causing phreatic explosions, followed by phreatomagmatic- or even magmatic explosions and ended by a lava extrusion. Satellite image analyses have recognized twelve circular features, comprising Bambang Maar, Gunungrowo Maar, and Gembaong Maar. Phisiographically, these maars are characterized by circular depressions which are surrounded by hills that are gently sloping down away from the crater or having a radier pattern morphology. Outcrops and drilling core in the circular areas that are considered as volcanic maars are lava fl ows, pyroclastic breccias, lapillistones, and tuffs, located far away from the eruption centres of Muria and Genuk Volcanoes. One of the circular features, i.e. Jepara Circular Feature, is also supported by negative anomaly (<30 mgal showing a circular pattern. In the future, a maar volcano could possibly erupt depending on the tectonic reactivity in the region.  

  5. Modelling of sediment transport at Muria peninsula coastal, Jepara

    International Nuclear Information System (INIS)

    Heni Susiati; Yarianto SBS; Wahyu Pandoe; Eko Kusratmoko; Aris Poniman

    2010-01-01

    Modelling of transport sediment modelling at Muria Peninsula have been done. In this study we had been used mathematical model that consist of hydrodynamics and sediment transport . Data input for modelling has been used tidal, monsoon wind, and river debit. Simulation result of sediment transport modelling showed that tides pattern and seasonal variations are the main causes of variations in the suspended sediment distribution in Muria Peninsula. (author)

  6. Hydrodynamics and sediment transport at Muria Peninsula NPP Site

    International Nuclear Information System (INIS)

    Heni Susiati; Berni A Subki; Harman A

    2011-01-01

    Coastal along the coast of the Muria Peninsula, particularly the location of the Muria NPP site candidate is a dynamic region, the interaction between physical oceanographic factors such as currents, waves and tides in the coastal sediments cause abrasion or accretion. Interactions have resulted in coastal dynamics needs to be considered in siting NPP is essential in order to plan. Capacity of hydro-oceanographic data is essential in order to plan the development of the Muria NPP. The process of selecting a safe site for hydro-oceanographic aspects carried out according to IAEA safety standards on site selection. For the evaluation stage of hydro oceanographic potential site (site survey stage), the analysis is more focused on the tidal along the northern coast, bathymetry, potential water resources and hydrologic systems in the Muria NPP siting locations, Jepara. The method used is a secondary, confirmation of field data collection and interpretation of modeling results. The results showed that the preparation for the construction of NPP need to be evaluated further to coastal conditions with respect to the increase coastal erosion in the area of prospective NPP siting. (author)

  7. Entrepreneurship: Assessing the Readiness of the New Jersey APN Workforce.

    Science.gov (United States)

    Cadmus, Edna; Johansen, Mary L; Zimmer, Phyllis Arn; Knowlton, David L

    There is an unprecedented opportunity to move advanced practice nurses (APNs) into primary care settings at a steady rate over the next 5 to 8 years. In addition, the opportunity for nurse-owned or nurse-led practices has never been greater. However, many APNs currently work in a structured environment where the employer focuses on the business aspects of the practice and the APN focuses primarily on clinical care. Often APNs are unaware of the entrepreneurial contribution they make to the practice. A Needs Assessment Survey was developed to better understand business and practice management knowledge and skills of APNs in New Jersey. The survey included 14 categories for competency development. Twelve of the 14 categories showed that APNs were at a novice or an advanced beginner level. APNs need to demonstrate their value and take a lead to help solve primary care access issues. This can only be accomplished if APNs are willing to seize the opportunity and overcome barriers and knowledge gaps through both formal and informal education to step out of their traditional positions into more independent roles.

  8. INTERPRETASI STRUKTUR BAWAH PERMUKAAN GUNUNG MURIA MENGGUNAKAN ANALISA DATA GRAVITASI

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    Nasrun Balulu

    2012-03-01

    Full Text Available A geophysical survey using gravity method was carried out in Muria  volcano. This research aimed to interpret the subsurface geology condition of the research area based on gravity data analysis. Research area is (47,6 x 45 km2    with 222 observation  points. Gravitymeter  LaCoste & Romberg type G-1118 MVR was used to    measure the  gravity field, and differential method of Global Positioning System (GPS was used to measure the position and elevation. Data processing was performed to gain complete Bouguer  anomaly of both residual and  regional. Bouguer density using graphical method resulted to the value of 2.67 gr/cm3.  Transformation to a horizontal plane was performed obtain by using equivalent mass method with horizontal level’s height of 1602 meters beyond the spheroid reference and equivalent The separation of regional anomaly and residual  anomaly  was  generated  through  upward  continuation  method  and  resulted  to  regional anomaly in the height of  15000 meters up the spheroid reference. The residual anomaly acquired by subtract the regional anomaly toward the complete Bouguer anomaly in a horizontal plane. The subsurface modelling of Muria  volcano and its surrounding was acquired from  Grav2DC for Windows. The result shows that Muria volcano and its surrounding was regionally controlled by rock resulted from volcanic processes as lava (density 2,91 gr/cm3. This volcanic rock due to the gravity collapse performed a caldera filled by andesit (density 2,58 gr/cm3. Another rock which is deposited in  Muria  volcano  are  tuff  from  Muria  Tuff  (density  2,4  gr/cm3,  tuff  sandstone  from  Patiayam formation (density 2,5 gr/cm3,  limestone from Bulu formation (density 2,7 gr/cm3, and  limestone from Ngrayong formation (density 2,8 gr/cm3. Keywords:Bouguer anomaly, Regional anomaly, Residual anomaly,  Modeling, Subsurface stracture.

  9. PEMISAHAN Zr – Hf SECARA SINAMBUNG MENGGUNAKAN MIXER SETTLER

    Directory of Open Access Journals (Sweden)

    Dwi Biyantoro

    2017-01-01

    Full Text Available ABSTRAK PEMISAHAN Zr – Hf SECARA SINAMBUNG MENGGUNAKANMIXER SETTLER. Telah dilakukan pemisahanZr – Hf secara sinambung menggunakan pengaduk pengenap (mixer settler 16 stage. Larutan umpan adalah zirkon nitrat dengan kadar Zr = 30786 ppm dan Hf = 499 ppm. Ekstraktan dipakai adalah solven 60 % TBP dalam kerosen dan larutan scrubbingyang dipakai adalah asam nitrat 1 M. Umpan masuk pada stageke 5 dikontakkan secara berlawanan arah dengan solven masuk pada stage ke 16 dan larutan scrubbing masuk pada stage ke 1. Tujuan penelitian ini adalah memisahkan unsur Zr dan Hf dari hasil olah pasir zirkon menggunakan solven TBP dengan alat mixer settler16 stage. Analisis umpan dan hasil proses pemisahan untuk zirkonium (Zr dilakukan dengan menggunakan alat pendar sinar-X, sedangkananalisis unsur hafnium (Hf menggunakan Analisis Pengaktifan Neutron (APN. Parameter penelitian dilakukan dengan variasi keasaman asam nitrat dalam umpan dan variasi waktu pada berbagai laju pengadukan. Hasil penelitian pemisahan unsur Zr dengan Hf diperolehkondisi optimum pada keasaman umpan 4 N HNO3, keseimbangan dicapai setelah 3jam dan laju pengadukan 3300 rpm. Hasil ekstrak  unsur zirkon (Zr diperoleh kadar sebesar 28577 ppm dengan efisiensi 92,76 % serta kadar pengotor hafnium (Hf sebesar 95 ppm. Kata Kunci: pemisahan Zr, Hf, ekstraksi, mixer settler, alat pendar sinar-X, APN. ABSTRACT SEPARATION of Zr - Hf CONTINUOUSLY USE THE MIXER SETTLER. Separation of Zr - Hf continuously using mixer settler 16 stage has been done. The feed solution is zircon nitrate concentration of Zr = 30786 ppm  and Hf = 499 ppm. As the solvent used extractant 60 % TBP in 40 % kerosene. Nitric acid solution used srubbing 1 M. The feed entered into stage to 5 is contacted with solvents direction on the stage to 16 and the scrubbing solution enter the stage to 1. The purpose of this study is to separate Zr and Hf of the results from the process of zircon sand using solvent TBP using 16 stage

  10. Economy Aspect for Nuclear Desalination Selection in Muria Peninsula

    International Nuclear Information System (INIS)

    Sudi, Ariyanto; Alimah, Siti

    2011-01-01

    An assessment of economy aspect for nuclear desalination selection has been carried out. This study compares the costs of water production for the Multi Stage Flash Distillation (MSF), Multi Effect Distillation (MED) and Reverse Osmosis (RO) desalination process coupled to PWR. Economic analysis of water cost are performed using the DEEP-3.1. The results of the performed case study of Muria Peninsula showed that the water cost to desalination process coupled with PWR nuclear power plant (at 5% interest rate, 2750 m 3 /day capacity, 28 o C temperature, 28.700 ppm TDS) with MSF plant is the highest (1.353 $/m 3 ), compared to 0.885 $/m 3 and 0.791 $/m 3 with the MED and RO plants respectively. As for MSF process, water cost by RO are also sensitive to variables, such as the interest rate, temperature and total salinity. However, MED process is sensitive to interest rate and temperature based on the economic aspect. MSF and MED plants produce a high-quality product water with a range of 1.0 - 50 ppm TDS, while RO plants produce product water of 200 - 500 ppm TDS. Water requirements for reactor coolant system in PWR type is about 1 ppm. Based on economic aspect and water requirements for reactor coolant system in PWR type, so co-generation of PWR and MED may be a favourable option for being applied in Muria Peninsula. (author)

  11. Economic Aspect for Nuclear Desalination Selection in Muria Peninsula

    International Nuclear Information System (INIS)

    Sudi, Ariyanto; Alimah, Siti

    2011-01-01

    An assessment of economy aspect for nuclear desalination selection has been carried out. This study compares the costs of water production for the Multi Stage Flash Distillation (MSF), Multi Effect Distillation (MED) and Reverse Osmosis (RO) desalination process coupled to PWR. Economic analysis of water cost are performed using the DEEP-3.1. The results of the performed case study of Muria Peninsula showed that the water cost to desalination process coupled with PWR nuclear power plant (at 5% interest rate, 2750 m 3 /day capacity, 28 o C temperature, 28.700 ppm TDS) with MSF plant is the highest (1.353 $/m 3 ), compared to 0.885 $/m 3 and 0.791 $/m 3 with the MED and RO plants respectively. As for MSF process, water cost by RO are also sensitive to variables, such as the interest rate, temperature and total salinity. However, MED process is sensitive to interest rate and temperature based on the economic aspect. MSF and MED plants produce a high-quality product water with a range of 1.0 - 50 ppm TDS, while RO plants produce product water of 200 - 500 ppm TDS. Water requirements for reactor coolant system in PWR type is about 1 ppm. Based on economic aspect and water requirements for reactor coolant system in PWR type, so co-generation of PWR and MED may be a favourable option for being applied in Muria Peninsula. (author)

  12. The Characterization of Muria mountain deformation in the period of 2010-2104

    International Nuclear Information System (INIS)

    Ari Nugroho; Irwan Gumilar

    2015-01-01

    Deformation monitoring activity for Muria Mountain is recommended by the IAEA to be carried out in five years. The goal of this activity is to identify the soil deformation and strain surrounding Muria regionally and locally, this data is beneficial to support safety and reliability aspect of candidate site for constructing the Nuclear Power Plant in Muria Peninsula. Since the year of 2010 to 2014 the deformation monitoring had been applied in five benchmarks which are Mijen, Rahtawu, Perdopo, Cranggang, and Ketek Putih. The monitoring has been done successfully in collaboration with the faculty of Geodesy ITB. Based on the analysis by using GAMIT 10.4 it can be concluded that until the year of 2014 the regional deformation surrounding the Muria is dominated by plate movement namely Sunda block which has the acceleration as fast as 2.2 cm/year. The local deformation at the 5 Benchmark indicates the presence of deformation as fast as 2 - 3 mm/year. The strain measurement demonstrates the presence of the strain rate at Northern Muria as big as 2 x 10"-"2 microstrain/year, which is higher than the number of consistent strain (5 x 10"-"8 microstrain/year), this mean there is an indication of deformation. (author)

  13. Lessons learned from testing the quality cost model of Advanced Practice Nursing (APN) transitional care.

    Science.gov (United States)

    Brooten, Dorothy; Naylor, Mary D; York, Ruth; Brown, Linda P; Munro, Barbara Hazard; Hollingsworth, Andrea O; Cohen, Susan M; Finkler, Steven; Deatrick, Janet; Youngblut, JoAnne M

    2002-01-01

    To describe the development, testing, modification, and results of the Quality Cost Model of Advanced Practice Nurses (APNs) Transitional Care on patient outcomes and health care costs in the United States over 22 years, and to delineate what has been learned for nursing education, practice, and further research. The Quality Cost Model of APN Transitional Care. Review of published results of seven randomized clinical trials with very low birth-weight (VLBW) infants; women with unplanned cesarean births, high risk pregnancies, and hysterectomy surgery; elders with cardiac medical and surgical diagnoses and common diagnostic related groups (DRGs); and women with high risk pregnancies in which half of physician prenatal care was substituted with APN care. Ongoing work with the model is linking the process of APN care with the outcomes and costs of care. APN intervention has consistently resulted in improved patient outcomes and reduced health care costs across groups. Groups with APN providers were rehospitalized for less time at less cost, reflecting early detection and intervention. Optimal number and timing of postdischarge home visits and telephone contacts by the APNs and patterns of rehospitalizations and acute care visits varied by group. To keep people well over time, APNs must have depth of knowledge and excellent clinical and interpersonal skills that are the hallmark of specialist practice, an in-depth understanding of systems and how to work within them, and sufficient patient contact to effect positive outcomes at low cost.

  14. Lithomorphological aspects of northern Muria region for location candidate of the NPP radioactive wastes repository

    International Nuclear Information System (INIS)

    Sucipta

    1995-01-01

    As a part of planning and construction of NPP in the northern Muria region, a location candidate of the NPP radioactive waste repository needs to be prepared. The objective of this studywas to investigate the suitability of the geomorphologic condition of the northern Muria region for the location. The geomorphologic elements were evaluated based on the geomorphologic criteria specified by the IAEA. This study was conducted through descriptive and scoring methods for the geomorphologic elements, especially the landform and the geomorphologic processes. Based on the results of the study, the study area could be classified into three classes of suitability for the location. These are three geomorphologic units of high suitability, three units of moderate suitability and four units of low suitability. By considering the total value of the geomorphologic condition suitability and the inhibiting factors of geomorphology, three high suitability units were selected, particularly in the region of Lemahabang and Genggrengan. (author). 6 refs, 7 figs

  15. A Surface Soil Radioactivity Mapping Has Been Carried Out at Muria Peninsula, Central Java

    International Nuclear Information System (INIS)

    Soepradto-Tjokrokardono; Nasrun-Syamsul; Supardjo-AS; Djodi-R-Mappa; Kurnia-Setyawan W

    2004-01-01

    The air of this mapping is to gain exposure dose value of the soil surface of Muria Peninsula. Central Java, in the area of 75 km radius from Ujung Lemah Abang. Lemah Abang is the proposed site of the first indonesian nuclear Power Plant. A radioactivity data obtained in 1995/1996 to 1998/1999 researches has been used for input data. For further analysis, a conversation factor multiplication is applied. This conversation factor is obtained from linear regression equation of the relationship between radioactivity and exposure values gained from re-measured randomly 44 points which are representative for high, medium, and low radiation areas obtained in 1995/1996 to 1998/1999 activities and it taking soil samples. The conversation data result is being constructed of the Surface Exposure Dose Map of Muria Peninsula. Those data show that the exposure dose of northern slope of Muria Volcano is relatively higher than that of southern slope, it means be harmonizing to the soil sample radioactivity values. The maximum radioactivity value of the soil samples is 3,56.10 -2 Bq/gram (α radiation), 8,22.10 -1 Bq/gram (β radiation) and 6,20.10 -1 Bq/gram (γ radiation) and the minimum values are 4,44 10 -3 Bq/gram (α radiation), 1,50. 10 -1 Bq/gram (β radiation) and 4,09. 10 -2 Bq/gram (γ radiation). (author)

  16. Favored use of anti-predator netting (APN) applied for the farming of clams leads to little benefits to industry while increasing nearshore impacts and plastics pollution.

    Science.gov (United States)

    Bendell, L I

    2015-02-15

    An overview of the efficacy of anti-predator netting (APN) used by the shellfish industry is presented. There is little support that the currently favored APN effectively protects farmed clams from predators. Evidence does suggest that APN leads to impacts and pollution. APN is an attractant for predators, e.g., crabs, by providing a refuge within Ulva sp. which attaches onto the surface of APN. APN entrains silt and organic matter and increases sediment temperatures degrading habitat underneath the APN. APN present hazards to fish and wildlife and is a source of plastics to the marine environment. The continued use of ineffective APN does not serve either the environment or industry well, and many of these issues could be addressed through the alternate use of "ancient" technology used by aboriginal people to maintain clam gardens; building of rock walls optimizing the amount of clam habitat thereby increasing numbers without the use of APN. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Evaluation of trace elements distribution in water, sediment, soil and cassava plant in Muria peninsula environment by NAA method

    International Nuclear Information System (INIS)

    Muryono, H.; Sumining; Agus Taftazani; Kris Tri Basuki; Sukarman, A.

    1999-01-01

    The evaluation of trace elements distribution in water, sediment, soil and cassava plant in Muria peninsula by NAA method were done. The nuclear power plant (NPP) and the coal power plant (CPP) will be built in Muria peninsula, so, the Muria peninsula is an important site for samples collection and monitoring of environment. River-water, sediment, dryland-soil and cassava plant were choosen as specimens samples from Muria peninsula environment. The analysis result of trace elements were used as a contributed data for environment monitoring before and after NPP was built. The trace elements in specimens of river-water, sediment, dryland-soil and cassava plant samples were analyzed by INAA method. It was found that the trace elements distribution were not evenly distributed. Percentage of trace elements distribution in river-water, sediment, dryland-soil and cassava leaves were 0.00026-0.037% in water samples, 0.49-62.7% in sediment samples, 36.29-99.35% in soil samples and 0.21-99.35% in cassava leaves. (author)

  18. Evaluation of trace elements distribution in water, sediment, soil and cassava plant in Muria peninsula environment by NAA method

    Energy Technology Data Exchange (ETDEWEB)

    Muryono, H.; Sumining; Agus Taftazani; Kris Tri Basuki; Sukarman, A. [Yogyakarta Nuclear Research Center, Yogyakarta (Indonesia)

    1999-10-01

    The evaluation of trace elements distribution in water, sediment, soil and cassava plant in Muria peninsula by NAA method were done. The nuclear power plant (NPP) and the coal power plant (CPP) will be built in Muria peninsula, so, the Muria peninsula is an important site for samples collection and monitoring of environment. River-water, sediment, dryland-soil and cassava plant were choosen as specimens samples from Muria peninsula environment. The analysis result of trace elements were used as a contributed data for environment monitoring before and after NPP was built. The trace elements in specimens of river-water, sediment, dryland-soil and cassava plant samples were analyzed by INAA method. It was found that the trace elements distribution were not evenly distributed. Percentage of trace elements distribution in river-water, sediment, dryland-soil and cassava leaves were 0.00026-0.037% in water samples, 0.49-62.7% in sediment samples, 36.29-99.35% in soil samples and 0.21-99.35% in cassava leaves. (author)

  19. The effect of modified benchmark on the accuracy of measuring the deformation at Muria

    International Nuclear Information System (INIS)

    Ari Nugroho

    2013-01-01

    The monitoring of deformation surrounding the Muria mountain is recommended by The IAEA (International Atomic Energy Agency). In addition, this study also to provide the data of deformation caused by the volcanic activity of Mount Muria, as a basic study in analyzing the volcanic hazard toward the NPP (Nuclear Power Plant). The main purpose of this study is to discover the accuracy between the two measurements by using the different BM (Benchmark). This study uses geodetic GPS (Global Positioning System) Trimble R7 GNSS. The measurement in the month of April to July 2011 used the standard BM and conducted in eight BM which are BKI (Bopkri), UJW (Ujung Watu), PDP (Perdopo), RTW (Rahtawu), RGG (Rengging), KTP (Ketek Putih), CRG (Cranggang), DM (Danyang Mulyo) and refer to one reference BM named Mijen. The measurement in the month of November 2011 used the modified BM and conducted in six BM which are BKI, PDP, RTW, RGG, KTP, CRG referred to the same reference BM named Mijen. These measurements resulted data in the range of 4-7 mm (horizontal), 16-28 mm (vertical), and in the range of 0.6 mm - 1.3 mm (horizontal), 0.3 mm – 0.6 mm, respectively. (author)

  20. Study of coastal line change modelling around the NPP site of Muria Peninsula

    International Nuclear Information System (INIS)

    Tumpal Pahala Tua Sinaga; Henu Susiati

    2007-01-01

    Coastal areas always changing due to two energies coming sea and land congregate. The changes are the forward-backward coastal lines alteration. The coastal lines alteration is caused by coastal sediment transport such as Long shore Sediment Transport and Cross-shore Sediment Transport. This research was aimed to model the sediment transport rate, direction and sediment transport volume and also to investigate the abrasion and accretion areas in Muria Peninsula. The method used in this sampling was purposive sampling method and data processing using NEMOS software. Overall result from the sediment transport model in Semenanjung Muria, the sediment transport rate were Q + =2471331.00 m 3 /year, Q - =-1325456.80 m 3 /year, Q gs =3796792.60 m 3 /year and Q net =1145874.40 m 3 /year; average abrasion and accretion distance were -0.982 m/year and 0.770 m/year, transport volume to right = 13431.15 m 3 /year and to left = -7203.53 m 3 /year. (author)

  1. SCHOOL OBSERVATION AS ONE OF THE ASSESSMENTS FOR ENGLISH EDUCATION DEPARTMENT STUDENTS OF MURIA KUDUS UNIVERSITY

    Directory of Open Access Journals (Sweden)

    Atik Rokhayani

    2017-04-01

    Full Text Available Nowadays, learning requires students to develop their knowledge through critical thinking. Knowledge is not just receiving the information but also interpreting the information. It requires new learning goals change the relationship between assessment and instruction. So, the lecturers need to assess the students’ ability to comprehend the materials. In addition, the lecturers have to take an active role about the purpose of the assessment and the content that is being assessed. There are many kinds of assessments used by the lecturers given to their students. For example: asking the students to do the discussion, test, questioning, observation etc. School observation tends to be familiar for the students of English Education Department of Muria Kudus University since by doing the observation they can face the real school condition. The students can observe the English teaching and learning process in the classroom. This paper focuses in AMEL (Approaches and Methods in English Language class. It discusses the application of school observation as one of the authentic assessment for English Education Department students of Muria Kudus University through exploring the approaches and methods used by Junior High School teachers in Kudus. In the end of the observation, the students have to report the discussion in form of poster presentation.

  2. The Identification of Financing Strategy for the Construction of NPP Type Opr-1000 at Muria Peninsula

    International Nuclear Information System (INIS)

    Moch-Djoko Birmano

    2006-01-01

    The study for identification of financing strategy for the construction of OPR-1000 at Muria Peninsula have been done. This study is continuation of previous study with title T he Economic and Financing Viability of the OPR-1000 Construction at Muria Peninsula . In the previous study have been the economic and financing viability of OPR-1000 construction. The economic viability was known by obtained the generation cost, electricity tariff and construction cost. The meanwhile, the financing viability was known by obtained Net Present Value (NPV), Internal Rate of Return (IRR) and Payback Period (P) by using KEPCO Spread Sheet. From the calculation of economic and financing viability in base case, have been obtained the result of electricity tariff, IRR, FNPV and Payback Period for total investment is 6.640 cent/kWh (after Value Added Tax), 10.37%, US$ 90.52 million and 12.11 years, respectively. From this result of economic and financing viability in base case, have been carried out sensitivity analysis to technical parameter (capacity factor) and economic parameter (discount rate). The result of sensitivity analysis to be used for identifying financing strategy in order to obtain the best and optimal economic and financing viability. (author)

  3. APNs taking the next step: disseminating practice information via effective poster presentations.

    Science.gov (United States)

    Bischof, Janet

    2013-02-10

    Advanced practice nurses (APNs) have a responsibility to share information from projects and research with other professionals. Poster presentations offer a way to visually share the information to a wide audience. Key elements include title, objective/purpose, data collection, results, analysis, implications for nursing, and appropriate references.

  4. Functional interpretation of a non-gut hemocoelic tissue aminopeptidase N (APN in a lepidopteran insect pest Achaea janata.

    Directory of Open Access Journals (Sweden)

    Thuirei Jacob Ningshen

    Full Text Available Insect midgut membrane-anchored aminopeptidases N (APNs are Zn(++ dependent metalloproteases. Their primary role in dietary protein digestion and also as receptors in Cry toxin-induced pathogenesis is well documented. APN expression in few non-gut hemocoelic tissues of lepidopteran insects has also been reported but their functions are widely unknown. In the present study, we observed specific in vitro interaction of Cry1Aa toxin with a 113 kDa AjAPN1 membrane protein of larval fat body, Malpighian tubule and salivary gland of Achaea janata. Analyses of 3D molecular structure of AjAPN1, the predominantly expressed APN isoform in these non-gut hemocoelic tissues of A. janata showed high structural similarity to the Cry1Aa toxin binding midgut APN of Bombyx mori, especially in the toxin binding region. Structural similarity was further substantiated by in vitro binding of Cry1Aa toxin. RNA interference (RNAi resulted in significant down-regulation of AjAPN1 transcript and protein expression in fat body and Malpighian tubule but not in salivary gland. Consequently, reduced AjAPN1 expression resulted in larval mortality, larval growth arrest, development of lethal larval-pupal intermediates, development of smaller pupae and emergence of viable defective adults. In vitro Cry1Aa toxin binding analysis of non-gut hemocoelic tissues of AjAPN1 knockdown larvae showed reduced interaction of Cry1Aa toxin with the 113 kDa AjAPN1 protein, correlating well with the significant silencing of AjAPN1 expression. Thus, our observations suggest AjAPN1 expression in non-gut hemocoelic tissues to play important physiological role(s during post-embryonic development of A. janata. Though specific interaction of Cry1Aa toxin with AjAPN1 of non-gut hemocoelic tissues of A. janata was demonstrated, evidences to prove its functional role as a Cry1Aa toxin receptor will require more in-depth investigation.

  5. The Distribution of Heavy Element From Fish, Algae, Water and Sea Sediment In Lemahabang Muria Peninsula

    International Nuclear Information System (INIS)

    Sukirno; J-Djati-Pramana; Sumining

    2005-01-01

    The analysis of heavy elements from fish, algae, water and sea sediments in Muria peninsula Jepara has been carried out using neutron activation analysis (NAA) method. Irradiation of sample was carried out for twelve hours with using Lazy Susan facility with neutron flux of 0.585x10 11 n.cm -2 .S -1 . Comparative mode of measurement was used for avoiding the effects of neutron flux parameters on the results. The result on analysis using gamma spectrometry with a Ge(Li) detector showed that there were 6 elements which observed. Those elements contained in algae, fish, water and sea sediment were Co, Sb, Sc, Fe, Cr and Cd. The highest element concentration found in sediment was Fe of 65.625 ± 3.12 % and the lowest was Co of 0.00256 ± 0.00045 μg/g for sea water. This method give precision and relative accuracy of < 10 % for all elements. (author)

  6. Konversi Rumput Laut Menjadi Monosakarida Secara Hidrotermal

    Directory of Open Access Journals (Sweden)

    Silvy Eka Andansari

    2014-09-01

    Full Text Available Rumput laut merupakan salah satu sumber devisa negara dan sumber pendapatan bagi masyarakat pesisir dan merupakan salah satu komoditi laut yang sangat populer dalam perdagangan dunia, karena pemanfaatannya yang demikian luas dalam kehidupan sehari-hari, baik sebagai sumber pangan, obat-obatan dan bahan baku industri. Pada proses hidrolisis biasanya menggunakan katalisator asam seperti HCl, asam sulfat. Bahan yang digunakan untuk proses hidrolisis adalah pati. Hidrolisis merupakan reaksi pengikatan gugus hidroksil / OH oleh suatu senyawa. Tujuan penelitian ini antara lain mempelajari proses, pengaruh waktu, suhu, dan konsentrasi katalis terhadap reaksi konversi, serta kinetika reaksi proses hidrolisis rumput laut menjadi monosakarida secara hidrotermal. Dari hasil analisa penelitian yang telah dilakukan, didapatkan analisa gula pereduksi menggunakan metode HPLC dan spektofotometer reagen Nelson-Somogyi. Hidrolisis termal rumput laut dengan katalis asam sulfat dapat menghasilkan gula reduksi. Dari hasil penelitian dan analisa yang telah dilakukan, semakin lama waktu hidrolisis, semakin tinggi suhu, dan semakin besar konsentrasi katalis yang diberikan dapat menghasilkan % gula reduksi yang besar yaitu pada kondisi 80 menit; 240°C; 1N katalis menghasilkan presentase gula reduksi sebesar 0,2848 %. Dengan reaksi yang didapatkan adalah reaksi orde 1, diperoleh energi aktivasi yang lebih kecil pada konsentrasi katalis 1N yaitu sebesar 12.675 J/mol.

  7. Measurement and Elemental Analysis of Muria Sea Water for Primary Water of PWR

    International Nuclear Information System (INIS)

    Dwi Biyantoro; Kris Tri Basuki

    2007-01-01

    Treatment process of water of free mineral and study area of processing of sea water to meet the need of water cooling of PWR. Desalination is a separation process used to reduce the dissolved salt content of saline water. All desalination processes involve three liquid streams: the saline feedwater (brackish water or seawater), low salinity product water, and very saline concentrate. Seawater Muria Jepara is feed type 1 with content salt is low and relative suspension and weight metals is low. There are two types of membrane process used for desalination: reverse osmosis (RO) and electrodialysis (ED). The starting of process is difficult and expensive. However, starting since 1950, desalination process appear to be economically practical for ordinary use. There are 3 key elements significantly affect to the technical performance and long term characteristic type, i.e. 1) energy, 2) corrosivity of seawater, and 3) desalination process technology. These elements closely inter related and important for design improvements and technical performance optimization. From the analysis of sea water of gulf Muria Jepara was found as follows : Fe = 0.176 ± 0.012 ppm, Pb = 0.612 ± 0.017 ppm, Cd = 52.567 ± 0.750 ppm, Cu = 0.044 ± 0.005 ppm, Zn = 0.061 ± 0.003 ppm, Mn = 0.057 ± 0.003 ppm, Ca between = 365.256 - 368.654 ppm, Na between = 9572.000 - 9775.000 ppm, Mg between 759.000 - 779.00 ppm and Ni = 0.524 ± 0.005 ppm. Cost production of process using reverse osmosis as around 0.9 - 1 US$/m3, while using electrodialysis is around 1.2 US$/m3, and by using evaporation process or distillation process is around 1.4 - 1.6 US$/m3. (author)

  8. Ethnobotany of utilization, role, and philosopical meaning of parijoto (Medinilla, spp) on Mount Muria in Kudus Regency, Central Java

    Science.gov (United States)

    Hanum, Alima Saida; Prihastanti, Erma; Jumari

    2017-08-01

    One of Indonesian plant species which has not been fully explored in terms of pharmacology is parijoto plant (Medinilla,spp). Medinilla,spp can be found on Mount Muria in Kudus regency, Central Java. This plant can be used as a traditional medicine which is derived from plants as a manifestation of active community participation in solving the healthy problems. Medinilla,spp is closely associated with the ethnic-majority area of mount Muria. Its utilization is still limited as the fruit to be consumed by pregnant women. It is necessary to do in-depth research as part of an effort in the utilization and conservation for the future. The purposes of this study were to determine the utilization, role, and philosophical meaning of Medinilla,spp. This research took place in three villages, they were Japan, Colo, and Pandak. Questionnaire and semi-structured interviews with community and key informants were used in this research. It was found out that Medinilla, spp majority were utilized as the fruit to be consumed by pregnant women and also used as medicine for diarrhea, mouth sores, anti inflammatory, anti-cancer, and anti-bacterial. The preparations process of traditional medical plants were by boiling (70%), way of brewing (15%), and consuming it freshly (15%). The composition of the ingredients were 90% used single material in the form of Medinilla,spp and 10% used addition ingredients such as ginger and turmeric. The philosophical meaning of Medinilla,spp for the people in Mount Muria region was that Medinilla, spp was not merely the fruit to be consumed by pregnant women, but Medinilla, spp was also considered as the fruit to heal various diseases. It referred to a belief that after salah prayer before hand by Sunan Muria, all diseases can be cured.

  9. Clinical significance of determination of changes of serum APN, BNP and ANF levels after treatment in patients with heart failure

    International Nuclear Information System (INIS)

    Ge Hengsong; Hu Min; Gao Xinchun

    2011-01-01

    Objective: To explore the significance of changes on serum APN, BNP and ANF levels after treatment in patients with heart failure. Methods: Serum BNP, ANF(with RIA) serum APN (with ELISA) levels were determined in 30 patients with heart failure both before and after treatment as well as in 35 normal controls. Results: Before treatment, serum APN level was significantly lower than those in controls (P<0.01), but serum BNP, ANF levels were apparently higher (P<0.01). After 1 month of treatment, the levels dropped markedly, but still remained obviously higher (P<0.05). Conclusion: Serum APN, BNP and ANF levels were closely related to the process of heart failure and were of clinical value of monitoring therapeutic effect and prognosis. (authors)

  10. Bounds on the degree of APN polynomials: the case of x −1 + g(x)

    DEFF Research Database (Denmark)

    Leander, Gregor; Rodier, François

    2011-01-01

    In this paper we consider APN functions $${f:\\mathcal{F}_{2^m}\\to \\mathcal{F}_{2^m}}$$ of the form f(x) = x −1 + g(x) where g is any non $${\\mathcal{F}_{2}}$$-affine polynomial. We prove a lower bound on the degree of the polynomial g. This bound in particular implies that such a function f is AP...

  11. Application of Nuclear Techniques for the Study of Sediment Geochronology in Coastal Waters of Location Tread NPP Ujung Lemahabang, Muria Peninsula

    International Nuclear Information System (INIS)

    Heni Susiati; Yarianto SBS; Fepriadi; Sarmin; Lubis, Ali Arman

    2008-01-01

    This investigation of geochronology of eight sediment cores, collected from Muria peninsula coastal has been carried out using natural radionuclide 210 Pb as a tracer through the sediment accumulation profile of unsupported 210 Pb. Sediment sample were collected using gravity core from 8 locations in Muria Peninsula coastal area. Sample was prepared and then analyzed using alpha spectrometer. The result of unsupported 210 Pb analysis shows that at stations with the depth of 19 - 28 em the sediment are 96 - 128 year old. (author)

  12. Correlation of Heavy Element in Sea Water and Sediment Samples from Peninsula of Muria

    International Nuclear Information System (INIS)

    Rosidi; Sukirno

    2007-01-01

    The analysis of heavy metals in marine environmental samples peninsula of Muria in the year 2004 has been carried out by using neutron activation analysis (NAA) method. The objective of this analysis is to know the distribution of heavy metals in the sea water and sediment, which accommodate the recent environmental data in supporting the license of site for the nuclear power plants (NPP). The result of the analysis show that there were only 5 observed elements found in sea water and sediment were Cd, Co, Cr, Sb and Sc. All of heavy metals from sea water (0.002 mg/l) are obviously lower than the threshold value established by environmental minister Act; Kep LH No 51/2004. From the observed data to use software of SPSS version 10, application of the Pearson correlation (r) shows that between Co with Sc was indicator show a highly positive significant correlation (r=0.928), between Cr with Sc was sufficiently positive high (r=0.756), between Cr with Cd was precisely (r=0.611) while Co with Sb shows the significantly low (r=0.429). (author)

  13. The Potential Pathways of Radionuclide Transformations On The Location Candidate of Nuclear Power Plants in Muria Peninsula

    International Nuclear Information System (INIS)

    Simandjuntak, A.G.; Syahrir

    1998-01-01

    The potential pathways of radionuclide transformations on the location candidate of nuclear power plants in Muria peninsula proposed to explain the potential of radionuclide pathways in the ecosystem to human based on annual effective dose calculations with elimination factor ≥ 1 of dose limit 50 mSv per year. The effective dose equivalent calculations used the program package Genll. The datum found from Bureau of Statistic Centre and NEWJEC was taken into calculations. The result of this study is very useful for radiological impact and environmental impact analysis. (author)

  14. Clinical significance of changes of serum APN, plasma VEGF, Hcy and urine albumin levels in patients with DM2 nephrosis

    International Nuclear Information System (INIS)

    Zhang Yuejin; Zhang Xinfang; Hu Ying

    2011-01-01

    Objective: Explore type 2 diabetes mellitus (DM2) and complicating with kidney disease patients homocysteine (Hcy), adiponectin (APN), vascular endothelial growth factor (VEGF) and urine albumin change relations. Methods: A normal controls and no complications of diabetes groups, combined with nephropathy. A comparison were measured of serum APN, plasma VEGF, Hcy and urine albumin level among. Results: Two groups of patients with diabetes fasting blood glucose level were no significant difference. Also there is no difference of BUN and Cr in three groups urine albumin in diabetic-nephropathy albumin increased significantly (P<0.01), than without complications group. Three groups of Hcy concentrations were significantly higher than that of normal control group (P<0.01), serum APN, plasma VEGF level obviously lower than normal control group, which increased in patients with nephropathy increased or reduced more apparently no complications group also have obvious difference (P<0.01). Conclusion: In patients with diabetes in two groups, plasma Hcy and urine albumin were significantly higher APN, and VEGF decreased significantly. In patients with nephropathy manifested more apparently, but renal damage did not enter decompensated period, clinically necessary for people with diabetes testing serum APN, plasma VEGF, Hcy and urine Albumin level, promptly intervention to prevent or relieve the further development of diabetes. (authors)

  15. Mercury in the River Basin Muriaé the stretch between the towns of Patrocínio de Muriaé and Itaperuna in the states of Minas Gerais and Rio de Janeiro, Brazil

    International Nuclear Information System (INIS)

    Meneses Silva, M. de; Teixeira de Andrade, G.

    2010-01-01

    The objective of this work is to study the environment contamination by mercury in the current sediments and alluvial plain sediments in the course of Muriaé River (between towns of Patrocinio de Muriaé (MG) – Itaperuna (RJ)) in Minas Gerais and Rio de Janeiro States where occurred the extraction of gold using the process of amalgamation by mercury during eighties and the beginning of the nineties. The methodology used was based in total and sequential extraction. The results in parts per billion (ng.g-1) showed that the total mercury ranged from 222,9 to 761,9 ng.g-1 in the current sediments et 233,6 to 2131,9 ng.g-1 in the alluvial plain sediments. Comparing theses values with the background of region (170 ng.g-1 to 365 ng.g-1) only two of the samples showed results according to this background. The others showed results above this interval. It was observed that when it comes to the availability of mercury to the aquatic environment and biota, 1% to 26,2% of the total mercury is in the exchangeable phase, easily available for the environment, 52,3% to 90,4 % is potentially available (in the oxidizable phase) and 0,2 % to 40 % is inert, imprisoned in the mineral's structure of the sediments ( residual phase)

  16. Sonolência excessiva diurna, apnéia do sono tipo central e distrofia miotônica

    Directory of Open Access Journals (Sweden)

    Rubens Reimão

    1985-12-01

    Full Text Available São relatados dois casos de distrofia miotônica acompanhada de sonolência excessiva diurna. A avaliação polissonográfica de noite inteira revelou grande número de apnéias do sono tipo central deflagrando despertares freqüentes. As apnéias dos tipos obstrutivo e misto ocorreram em níveis normais e não se constatou hipoxia. Houve diminuição da eficiência do sono e redução dos estágios 3, 4 e REM. A apnéia central e a sonolência diurna que acarreta representariam manifestações precoces do comprometimento do sistema nervoso central na distrofia miotônica.

  17. The Osteogenesis Effect and Underlying Mechanisms of Local Delivery of gAPN in Extraction Sockets of Beagle Dogs

    Science.gov (United States)

    Hu, Hongcheng; Pu, Yinfei; Lu, Songhe; Zhang, Kuo; Guo, Yuan; Lu, Hui; Li, Deli; Li, Xuefen; Li, Zichen; Wu, Yuwei; Tang, Zhihui

    2015-01-01

    A plastic and biodegradable bone substitute consists of poly (l-lactic-co-glycolic) acid and 30 wt % β-tricalcium phosphate has been previously fabricated, but its osteogenic capability required further improvement. We investigated the use of globular adiponectin (gAPN) as an anabolic agent for tissue-engineered bone using this scaffold. A qualitative analysis of the bone regeneration process was carried out using μCT and histological analysis 12 weeks after implantation. CBCT (Cone Beam Computed Tomography) superimposition was used to characterise the effect of the different treatments on bone formation. In this study, we also explored adiponectin’s (APN) influence on primary cultured human jaw bone marrow mesenchymal stem cells gene expressions involved in the osteogenesis. We found that composite scaffolds loaded with gAPN or bone morphogenetic protein 2 (BMP2) exhibited significantly increased bone formation and mineralisation following 12 weeks in the extraction sockets of beagle dogs, as well as enhanced expression of osteogenic markers. In vitro investigation revealed that APN also promoted osteoblast differentiation of primary cultured human jaw bone marrow mesenchymal stem cells (h-JBMMSCs), accompanied by increased activity of alkaline phosphatase, greater mineralisation, and production of the osteoblast-differentiated genes osteocalcin, bone sialoprotein and collagen type I, which was reversed by APPL1 siRNA. Therefore, the composite scaffold loaded with APN exhibited superior activity for guided bone regeneration compared with blank control or Bio-Oss® (a commercially available product). The composite scaffold with APN has significant potential for clinical applications in bone tissue engineering. PMID:26492241

  18. The Osteogenesis Effect and Underlying Mechanisms of Local Delivery of gAPN in Extraction Sockets of Beagle Dogs

    Directory of Open Access Journals (Sweden)

    Hongcheng Hu

    2015-10-01

    Full Text Available A plastic and biodegradable bone substitute consists of poly (l-lactic-co-glycolic acid and 30 wt % β-tricalcium phosphate has been previously fabricated, but its osteogenic capability required further improvement. We investigated the use of globular adiponectin (gAPN as an anabolic agent for tissue-engineered bone using this scaffold. A qualitative analysis of the bone regeneration process was carried out using μCT and histological analysis 12 weeks after implantation. CBCT (Cone Beam Computed Tomography superimposition was used to characterise the effect of the different treatments on bone formation. In this study, we also explored adiponectin’s (APN influence on primary cultured human jaw bone marrow mesenchymal stem cells gene expressions involved in the osteogenesis. We found that composite scaffolds loaded with gAPN or bone morphogenetic protein 2 (BMP2 exhibited significantly increased bone formation and mineralisation following 12 weeks in the extraction sockets of beagle dogs, as well as enhanced expression of osteogenic markers. In vitro investigation revealed that APN also promoted osteoblast differentiation of primary cultured human jaw bone marrow mesenchymal stem cells (h-JBMMSCs, accompanied by increased activity of alkaline phosphatase, greater mineralisation, and production of the osteoblast-differentiated genes osteocalcin, bone sialoprotein and collagen type I, which was reversed by APPL1 siRNA. Therefore, the composite scaffold loaded with APN exhibited superior activity for guided bone regeneration compared with blank control or Bio-Oss® (a commercially available product. The composite scaffold with APN has significant potential for clinical applications in bone tissue engineering.

  19. The economic and financing viability of the OPR-1000 construction at Muria Peninsula

    International Nuclear Information System (INIS)

    Moch Djoko Birmano; Mochamad Nasrullah

    2005-01-01

    The study of the economic and financing viability of the OPR-1000 construction at Muria Peninsula have been done. This study is carried out with steps as follows: updating of newest OPR-1000 technical and economic data; survey of financing sources; the calculation of electricity generation cost, electricity tariff, construction cost of OPR-1000; and calculation of OPR-1000 financing viability by using feasibility criteria such as Net Present Value (NPV), Internal Rate of Return (IRR) and capital payback period. The calculation of generation cost, electricity tariff, construction cost and financing viability criteria (IRR, NPV, Payback Period)by using KEPCO Spread Sheet. From the results of calculations how that the electricity generation cost is 4.0866 cent/kWh, while the electricity tariff is 6.6399 cent/kWh(after Value Added Tax). The total construction cost of OPR-1000 is US $4,092.09 million (included interest and financial fee, excluded initial nuclear fuel). The calculation of financing viability in base case obtained that value of IRR, NPV and Payback Period for total investment is 10.37%. US$90.52 million and 12.11 years respectively. From these results can be concluded that with the electricity tariff of 6.640 cent/kWh or 0.0664 US$/kWh, basically this project of OPR-1000 construction is very feasible and beneficial. From investment side, this project can attract investor because the rate of capital return is high enough, profit in the end of economic life is big enough and payback period is short. (author)

  20. Developing the role of Swedish advanced practice nurse (APN) through a blended learning master's program: Consequences of knowledge organisation.

    Science.gov (United States)

    Bergström, Peter; Lindh, Viveca

    2018-01-01

    This paper reports on a research study conducted with a group of nurses in Sweden enrolled in a newly developed blended learning master's programme to become advanced practice nurses (APNs). As background, the paper presents the regional needs the programme is intended to address and describes how the programme was designed. The aim was to understand how, from students' perspective, the nurse master's programme structured knowledge for their future position as APNs. The research question focuses on how the master's programme prepares students by meeting their diverse needs for knowledge. Empirical material was collected at two times during the students' first and second years of study through semi-structured qualitative interviews. The findings highlight the process in which these master's students gained a more advanced identity of becoming APNs. This process demonstrates how students perceive their current position as nurses based on a discourse of knowledge in relation to the practical and theoretical knowledge they encounter in the master's programme. This article concludes by recommending that attention should be paid to developing APN role models in the current Swedish healthcare system. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Educating APNs for Implementing the Guidelines for Adolescents in "Bright Futures: Guidelines of Health Supervision of Infants, Children, and Adolescents."

    Science.gov (United States)

    Porter, Cornelia P.; Pender, Nola J.; Hayman, Laura L.; Armstrong, Myrna L.; Riesch, Susan K.; Lewis, Mary Ann

    1997-01-01

    Discusses recommendations for preparing advanced practice nurses (APNs) to implement guidelines of a health curriculum: (1) ensuring age-appropriate teaching; (2) emphasizing the complex relationships of race/ethnicity, socioeconomic status, and gender; (3) reinforcing the self-care and resilience of adolescents; and (4) examining transitions…

  2. 68Ga-DOTA-NGR as a novel molecular probe for APN-positive tumor imaging using MicroPET.

    Science.gov (United States)

    Zhang, Jun; Lu, Xiaoli; Wan, Nan; Hua, Zichun; Wang, Zizheng; Huang, Hongbo; Yang, Min; Wang, Feng

    2014-03-01

    Aminopeptidase N (APN) is selectively expressed on many tumors and the endothelium of tumor neovasculature, and may serve as a promising target for cancer diagnosis and therapy. Asparagine-glycine-arginine (NGR) peptides have been shown to bind specifically to the APN receptor and have served as vehicles for the delivery of various therapeutic drugs in previous studies. The purpose of this study was to synthesize and evaluate the efficacy of a (68)Ga-labeled NGR peptide as a new molecular probe that binds to APN. NGR peptide was conjugated with 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA) and labeled with (68)Ga at 95°C for 10 min. In vitro uptake and binding analysis was performed with A549 and MDA-MB231 cells. Biodistribution of (68)Ga-DOTA-NGR was determined in normal mice by dissection method. (68)Ga-DOTA-NGR PET was performed in A549 and MDA-MB231 xenografts, and included dynamic and static imaging. APN expression in tumors and new vasculatures was analyzed by immunohistochemistry. The radiochemical purity of (68)Ga-DOTA-NGR was 98.0% ± 1.4% with a specific activity of about 17.49 MBq/nmol. The uptake of (68)Ga-DOTA-NGR in A549 cells increased with longer incubation times, and could be blocked by cold DOTA-NGR, while no specific uptake was found in MDA-MB231 cells. In vivo biodistribution studies showed that (68)Ga-DOTA-NGR was mainly excreted from the kidney, and rapidly cleared from blood and nonspecific organs. MicroPET imaging showed that high focal accumulation had occurred in the tumor site at 1 h post-injection (pi) in A549 tumor xenografts. A significant reduction of tumor uptake was observed following coinjection with a blocking dose of DOTA-NGR, whereas only mild uptake was found in MDA-MB231 tumor xenografts. Tumor uptake, measured as the tumor/lung ratio, increased with time peaking at 12.58 ± 1.26 at 1.5 h pi. Immunohistochemical staining confirmed that APN was overexpressed on A549 cells and neovasculature. (68)Ga

  3. Genome-wide map of Apn1 binding sites under oxidative stress in Saccharomyces cerevisiae.

    Science.gov (United States)

    Morris, Lydia P; Conley, Andrew B; Degtyareva, Natalya; Jordan, I King; Doetsch, Paul W

    2017-11-01

    The DNA is cells is continuously exposed to reactive oxygen species resulting in toxic and mutagenic DNA damage. Although the repair of oxidative DNA damage occurs primarily through the base excision repair (BER) pathway, the nucleotide excision repair (NER) pathway processes some of the same lesions. In addition, damage tolerance mechanisms, such as recombination and translesion synthesis, enable cells to tolerate oxidative DNA damage, especially when BER and NER capacities are exceeded. Thus, disruption of BER alone or disruption of BER and NER in Saccharomyces cerevisiae leads to increased mutations as well as large-scale genomic rearrangements. Previous studies demonstrated that a particular region of chromosome II is susceptible to chronic oxidative stress-induced chromosomal rearrangements, suggesting the existence of DNA damage and/or DNA repair hotspots. Here we investigated the relationship between oxidative damage and genomic instability utilizing chromatin immunoprecipitation combined with DNA microarray technology to profile DNA repair sites along yeast chromosomes under different oxidative stress conditions. We targeted the major yeast AP endonuclease Apn1 as a representative BER protein. Our results indicate that Apn1 target sequences are enriched for cytosine and guanine nucleotides. We predict that BER protects these sites in the genome because guanines and cytosines are thought to be especially susceptible to oxidative attack, thereby preventing large-scale genome destabilization from chronic accumulation of DNA damage. Information from our studies should provide insight into how regional deployment of oxidative DNA damage management systems along chromosomes protects against large-scale rearrangements. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  4. PENGGUNAAN AUGMENTED REALITY UNTUK MENSIMULASIKAN DEKORASI RUANGAN SECARA REAL TIME

    OpenAIRE

    Ulva Erida Nur Rochmah; Aris Rakhmadi

    2016-01-01

    Abstrak Mendekorasi ruangan merupakan kegiatan  yang memakan banyak waktu dan tenaga, terutama jika objek yang digunakan besar dan berat. Akan merepotkan jika seseorang harus menggeser setiap objek untuk menentukan letak yang sesuai. Hal ini dapat dihindari dengan menggunakan aplikasi berbasis Augmented Reality. Augmented Reality merupakan sebuah teknologi untuk menggabungkan dunia nyata dan dunia virtual dengan cara menampilkan objek-objek virtual di dunia nyata secara real time. Tujuan uta...

  5. PxAPN5 serves as a functional receptor of Cry2Ab in Plutella xylostella (L.) and its binding domain analysis.

    Science.gov (United States)

    Pan, Zhi-Zhen; Xu, Lian; Liu, Bo; Zhang, Jing; Chen, Zheng; Chen, Qing-Xi; Zhu, Yu-Jing

    2017-12-01

    Lepidopteran midgut aminopeptidases N (APNs) are widely studied for their potential roles as one of the receptors for Bacillus thuringiensis (Bt) crystal toxins. In the present study, a loss of function analyses by RNAi (RNA interference) silencing of the Plutella xylostella APN5 (PxAPN5), a binding protein of Bt crystal toxin Cry2Ab, were performed. The knocking down of PxAPN5 in P. xylostella larvae greatly reduced their susceptibility to Cry2Ab and led to a decrease of Cry2Ab binding to P. xylostella midgut. Four truncated fragments of PxAPN5 were further constructed and expressed in Escherichia coli (E.coli) to find the binding region of PxAPN5 to Cry2Ab. The ligand blot result indicated that D1 domain (residues 1-262) and D3 domain (residues 510-620) of PxAPN5 could specially bind to Cry2Ab. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. [Being cared for and caring: living with multiple chronic diseases (Leila)-a qualitative study about APN contributions to integrated care].

    Science.gov (United States)

    Müller-Staub, Maria; Zigan, Nicole; Händler-Schuster, Daniela; Probst, Sebastian; Monego, Renate; Imhof, Lorenz

    2015-04-01

    Living with multiple chronic diseases is complex and leads to enhanced care needs. To foster integrated care a project called "Living with chronic disease" (Leila) was initiated. The aim was to develop an Advanced Practice Nursing (APN) service in collaboration with medical centers for persons who are living with multiple chronic diseases. The following research questions were addressed: 1. What are patients' experiences, referring physicians and APNs with the Leila-Service? 2. How are referral processes performed? 3. How do the involved groups experience collaboration and APN role development? A qualitative approach according grounded theory of Corbin and Strauss was used to explore the experiences with the Leila project and the interaction of the persons involved. 38 interviews were conducted with patients who are living with multiple chronic diseases, their APN's and the referring physicians. The findings revealed "Being cared for and caring" as main category. The data demonstrated how patients responded to their involvement into care and that they were taken as serious partners in the care process. The category "organizing everyday life" describes how patients learned to cope with the consequences of living with multiple chronic diseases. "Using all resources" as another category demonstrates how capabilities and strengths were adopted. The results of the cooperation- and allocation processes showed that the APN recognition and APN role performance have to be negotiated. Prospective APN-services for this patient population should be integrated along with physician networks and other service providers including community health nursing.

  7. AKTIVITAS HEPATOPROTEKTOR BATANG FIBRAURE TINCTORIA LOUR SECARA IN VIVO

    Directory of Open Access Journals (Sweden)

    Ika Fikriah

    2012-06-01

    Full Text Available Study on Fibraurea tinctoria Lour (FT stems gives information about its traditional utility as  yellow fever treatment. Research of antecedent of FT stem proved that inhibited lipid peroxidation more effective than tocopherol acetate. These study was intended to prove hepatoprotector activity of ethanolic FT stem extract by in vivo. FT stem extract was macerated using absolute ethanol during 5 days that was repeated  3 times . FT stem extract hepatoprotector activity by in vivo was tested using carbon tetrachloride induced hepatotoxicity on Wistar rat. They were given FT stem extract orally once a day at dose 50, 100, and 200 mg/kgBW and Curcumin at dose 50 mg/KgBW as positive control.  After 10 days, all groups were examined liver function (SGOT, SGPT, ALP, liver Malonedialdehide (MDA level by Thiobarbituric acid method,  and liver histopathology by Haemotoxylin-Eosin staining. Group that induced by CCl4 showed significant elevation of SGOT, SGPT and ALT also Liver MDA than group control. FT stem extract treatment inhibited elevation of SGOT, SGPT, ALT and Liver MDA significantly.Qualitative histopathological examination on Group 2 showed extensive fibrosis and necrosis, along with  periportal PMN and lymphocyte infiltration. FT stem extract treatment inhibited pathological change that was induced by CCl4. Dose elevation showed tendency of stronger inhibition on liver cell tissue destruction and inflammation. Key words: Fibraurea tinctoria, hepatoprotector, in vivo   Abstrak Penelusuran secara etnobotani, batang Fibraurea tinctoria Lour (FT digunakan untuk obat sakit kuning. Penelitian pendahuluan batang FT berkemampuan meredam peningkatan lipid peroksidasi secara in vitro yang lebih kuat dibandingkan dengan tokoferol asetat. Membuktikan khasiat ekstrak etanol batang FT sebagai hepatoprotektor secara in vivo. Batang FT dimaserasi dengan etanol absolut selama 3 x 5 hari. Uji hambatan kerusakan hati secara in vivo digunakan model tikus yang

  8. Determination of heavy toxic metals in the environment indicator specimens (water, river sediment and kangkung plant) of Muria terrestrial

    International Nuclear Information System (INIS)

    J Djati Pramana; Sukirno; Bambang Irianto

    2004-01-01

    Analysis and evaluation contain of heavy toxic metals in the water kangkung plant (Ipomea reptans poir) and river sediment of five rivers sampling location at peninsula Muria region by NAA Instrumental method has been done. The method of sampling. preparation although analysis method according to standard procedure of environmental specimens analysis. Accordingly the quality standard of water group C although group D. the sample from fifth river location sampling was under allowed maximum Cd concentration. Correlation between variable location and kind of indicators to heavy metal concentration was shown by coefficient of Pearson correlation. Interpretation by statistic correlation was obtained. Correlation between kind indicators was indicated that river water has significant correlation with the kangkung plant about Cd concentration. (author)

  9. Spreading Design of Radioactivity in Sea Water, Algae and Fish Samples inthe Coastal of Muria Peninsula Area

    International Nuclear Information System (INIS)

    Sutjipto; Muryono; Sumining

    2000-01-01

    Spreading design of radioactivity in sea water, brown algae (phaeopyceae)and kerapu fish (epeniphelus) samples in the coastal of Muria peninsula areahas been studied. This research was carried out with designed beside to knowspreading each radioactivity but also spreading design in relation to thecontent of Pu-239 and Cs-137. Samples taken, preparation and analysis basedon the procedures of environmental radioactivity analysis. The instrumentused for the analysis radioactivity were alpha counter with detector ZnS, lowlevel beta counter modified P3TM-BATAN with detector GM and spectrometergamma with detector Ge(Li). Alpha radioactivity obtained of sea water, algaeand fish were the fluctuation form of the natural background. Radionuclide ofPu-239 in samples not detect, because its concentration/radioactivity stillbelow the maximum concentration detection value of Pu-239 for algae and fishwas that 1.10 Bq/g, whereas for sea water was that 0.07 Bq/mL. Result for theradioactivity which give the highest alpha radioactivity obtained on thekerapu fish was that 1.56 x 10 -3 Bq/g, beta radioactivity on sea water wasthat 1.75 x 10 2 mBq/L, gamma radioactivity of K-40 on brown algae was that3.72 x 10 -2 Bq/g and gamma radioactivity of Tl-208 on fish as mentionedabove was that 1.35 x 10 -2 Bq/g. All the peak spectrum gamma energy ofCs-137 do not detect with gamma counter, so there are not the radionuclide ofCs-137 in the samples. Spreading design of radioactivity which occur in thecoastal of Muria peninsula area for alpha radioactivity was found on kerapufish, beta radioactivities on sea water and gamma radioactivity on brownalgae and kerapu fish. (author)

  10. The effect of time duration in the network and radial method toward the accuracy in measuring the deformation at Muria

    International Nuclear Information System (INIS)

    Ari Nugroho and Hadi Suntoko

    2011-01-01

    The Deformation monitoring activities in the vicinity of Mount Muria are recommended by the IAEA (International Atomic Energy Agency) to be done for 5 years. The purpose of these activities is to determine the rate of the deformation caused by the volcanic activity of Mount Muria, as a basic study in analyzing the volcanic hazard toward the NPP (Nuclear Power Plant). The whole coordinate points measured encompass the district of Jepara, Pati, Demak, and Kudus. In 2010 deformation measurements were periodically conducted for 4 times a year using two geodetic GPS units of Trimble R7 GNSS type through the network method. The measurements were carried out at seven points of interest and at one reference point in March, April, May and December. Each session of the measurements was performed for 2.5 hours. In 2011 the deformation measurements were periodically conducted for 4 times a year by means of the radial method. The measurements were made at eight points of interest and at one reference point in April and May, June and July. Each session of measurements was performed for 10 hours. Based on the results of the measurements by means of the network method in 2010, it was concluded that the range of horizontal and vertical accuracy is between 6-10 mm and 25-46 mm, while the results of the measurements of the radial method in 2011 is 4-7 mm, and 16-28 mm respectively. Furthermore, it provides the evidence that the radial method tends to has better result than the network method if it is applied 4 times longer than the network method, resulting the accuracy below 7 mm and 28 mm for horizontal and vertical respectively. (author)

  11. IMPLEMENTASI POPULATION RESIZING ON FITNESS IMPROVEMENT GENETIC ALGORITHM (PROFIGA) UNTUK OPTIMASI RUTE KUNJUNGAN PROMOSI UNIVERSITAS MURIA KUDUS BERBASIS ANDROID DAN GOOGLE MAPS API

    OpenAIRE

    Tri Listyorini; Syafiul Muzid

    2016-01-01

    Tim Promosi Universitas Muria Kudus (UMK) melakukan kunjungan promosi ke sekolah menengah atas pada setiap tahun. Kunjungan tersebut dilakukan ke sekolah-sekolah menengah atas di wilayah Kudus, Jepara, Pati, Demak, Rembang dan Purwodadi. Untuk memudahkan kunjungan, setiap kunjungan dibatasi sekitar 15 (lima belas) sekolah. Namun pada saat melakukan kunjungan, tim tersebut mengalami kesulitan dalam menentukan rute kunjungan sekolah. Hal ini dikarenakan jarak sekolah yang dikunjungi cukup jauh ...

  12. [Quality of advanced practice nurse counseling in home care settings (APN-BQ): psychometric testing of the instrument].

    Science.gov (United States)

    Petry, Heidi; Suter-Riederer, Susanne; Kerker-Specker, Carmen; Imhof, Lorenz

    2014-12-01

    Patient centred and individually-tailored counselling of older people with a chronic condition who live at home is a useful intervention to support their independence. The paper presents the development and psychometric testing of the APN-BQ Instrument, to measure patient-centeredness. To measure the quality of an in-home counselling intervention, a 23-item questionnaire was developed and tested with 206 people 80 years and older. Principal component analysis with Varimax Rotation was conducted (n = 206). Analysis revealed a four factor (fs = 0.91) model scoring in 19 items. All factors loaded > 0.45. Cronbach's alpha was 0.86. The utility and acceptance of the instrument was confirmed by the high response rate (100 %) and the fact that participants answered 98.8 % of all questions. The APN-BQ has shown to be a reliable Instrument with good content and construct validity. It is a tool for APNs to measure structure, process, and outcome quality of a patient-centred and individually-tailored counselling program, including the degree of patient participation, and patient empowerment.

  13. The Analysis of Heavy Metal in Sea Water and Sediment from MuriaPeninsula Coastal Area by NAA Method

    International Nuclear Information System (INIS)

    TS, Susanna; Sukirno

    2000-01-01

    The analysis of heavy metal in sea water and sediment taken from Muriacoastal sites in Central Java has been carried out. This research aimed tosupport the EMSB and Ocean Radioecology programme. The sea water sample wasdried with electrical brazier till crystal form, and balanced. Whereas thesediment sample was cleaned, dried at opened air, powdered, screened andhomogenized. Irradiation of samples and standard were done for twelve hoursusing Lazy Susan facility, Kartini reactor with neutron flux of 5.85 x10 10 .n.cm -2 .s -1 . Comparative method of measurements was used foravoiding the effects of neutron flux parameters on the results. Using gammaspectrometer equipment with a Ge(Li) detector and multi channel analyzer with4096 channels, 7 elements were concealed in the sea water; i.e. Fe, Se, Co,Cr, Ce, Sm and Sc were detected, whereas in the sediment sample concealed 10elements were detected, i.e. Fe, Se, Co, Cr, As, Ce, Sm, Th, U and Sc. It wasfound that the elements concentrations in the sediment sample from Muria baywere higher than those elements concentrations in the sea water sample. Theconcentrations of Fe, Se, Co, Cr, Ce, Sm and Sc in the sediment sample fromMuria peninsula coastal area were Fe = 19.923 ± 2.162%, Se = 1.320 ±0.141 ppm, Co = 0.570 ± 0.066 ppm, Cr = 0.410 ± 0.031 ppm, As = 0.500± 0.043 ppm, Ce = 0.774 ± 0.210 ppm, Sm = 1.860 ± 0.210 ppm, Th1.930 ± 0.173 ppm, U = 0.663 ± 0.027 ppm, dan Sc = 0.190 ± 0.003ppm, whereas the concentration elements in the sea water sample were Fe 0.112± 0.007%, Se = 0.305 ± 0.008 ppm, Co = 0.047 ± 0.002 ppm, Cr 0.023± 0.001 ppm, Ce = 0.022 ± 0.001 ppm, Sm = 14 ± 0.8 ppb dan Sc = 2.4ppb, respectively. (author)

  14. Distribution of Heavy Metal Elements in the Sea Water, Algae and Fish ofMuria Peninsula Area

    International Nuclear Information System (INIS)

    Djati-Pramana, J; Agus-Taftazani; Sudarmadji

    2000-01-01

    Analysis of heavy metal elements in the specimens of sea water, brownalgae and kerapu fish from two area sampling Lemah Abang and Semat beach byINAA method was done. The same of such specimens from Krakal beach was takenfor control specimen. The aim of this investigation was to obtain a part ofinput data for EMSB program. Preparation after sampling was performed asfollows. Sea water sample was concentrated using 1/5 times of the initialvolume. Algae and fish specimens were crushed using N 2 liquid, dried at thefreeze dryer than were homogenized and screened through 100 mesh. The threeof those specimens were irradiated together for 12 hours in the Lazy Susanirradiation facility of Kartini reactor. Flux neutron was 5.85 . 10 10 n/cm 2 .sec. The heavy metal elements that could be identified were Sm, Se,Cr, Zr, Fe and Co. Concentration in the specimens from Muria peninsula wasrelatively higher comparated to control specimens. This might be use to thefound of these indicators to concentrated that of heavy metals from sea wateror their environment which has a higher concentration. From t test for 95 %probability to control specimens was showed that these was a significantdifference from all the detected elements. From the obtained data there was apollution indication in the area at the period of sampling. (author)

  15. Perawatan ortodontik pada kasus periodontitis kronis dengan kerusakan tulang infraboni secara menyeluruh

    OpenAIRE

    Susanto, Stephanie Adelia; Farmasyanti, Cendrawasih Andusyana; Kuswayuning, Kuswayuning

    2016-01-01

    Penyakit periodontal merupakan penyakit inflamasi yang mempengaruhi jaringan periodontal dan menyebabkan hilangnya perlekatan jaringan ikat dengan tulang alveolar. Peningkatan kedalaman probing dengan kombinasi faktor usia pasien, onset dan kecepatan perkembangan penyakit, dan kondisi psikologis akan mempengaruhi rencana dan prognosis perawatan. Pergerakan gigi secara ortodontik pada individu dewasa dengan kondisi periodontal perlu disertai dengan kontrol akumulasi plak secara berkala dan pen...

  16. PENGGUNAAN AUGMENTED REALITY UNTUK MENSIMULASIKAN DEKORASI RUANGAN SECARA REAL TIME

    Directory of Open Access Journals (Sweden)

    Ulva Erida Nur Rochmah

    2016-12-01

    Full Text Available Abstrak Mendekorasi ruangan merupakan kegiatan  yang memakan banyak waktu dan tenaga, terutama jika objek yang digunakan besar dan berat. Akan merepotkan jika seseorang harus menggeser setiap objek untuk menentukan letak yang sesuai. Hal ini dapat dihindari dengan menggunakan aplikasi berbasis Augmented Reality. Augmented Reality merupakan sebuah teknologi untuk menggabungkan dunia nyata dan dunia virtual dengan cara menampilkan objek-objek virtual di dunia nyata secara real time. Tujuan utama dari penelitian ini adalah untuk menciptakan suatu aplikasi Android dengan menggunakan Augmented Reality yang dapat digunakan untuk menggantikan objek nyata dengan objek virtual 3D sehingga memudahkan pengguna dalam mensimulasikan dekorasi ruangan. Aplikasi ini bekerja dengan cara memindai marker yang sudah dicetak pada selembar kertas. Jika marker telah terdeteksi, objek 3D berupa perabot akan ditampilkan di kamera aplikasi. Pengguna dapat memindah lokasi, memutar, dan mengubah ukuran objek untuk mensimulasikan tata letak ruangan. Hasil penelitian ini adalah aplikasi Android berbasis Augmented Reality yang dapat digunakan untuk mensimulasikan dekorasi ruangan secara real time. Kata Kunci: augmented reality, dekorasi, interior, marker Abstract Decorating the room is an activity that takes a lot of time and effort, especially if the object is large and heavy. It would be inconvenient if someone has to drag each object to determine the appropriate location. This problem can be avoided using an Augmented Reality-based application. Augmented reality is a technology that combine the real world and the virtual world by displaying virtual object in real world. The main purpose of this research is to create an Android application using Augmented reality  that can be used to replace the real object with virtual 3D object, making it easier for the user to simulate the decoration of the room. This application works by scanning the marker that has been printed on a

  17. Study on the changes of serum adiponectin (APN), insulin, C-reactive protein (CRP) and leptin levels after one year treatment in patients with type 2 diabetes

    International Nuclear Information System (INIS)

    Du Tongxin; Wang Zizheng; Wang Shukui; Li Yan; Fu Lei; Lin Yanli; Qu Wei; Qi Shaokang; Tao Xiaojun

    2005-01-01

    Objective: To investigate the β-cell function status and possible mechanism of insulin resistance in patients with type 2 diabetes through studies on the changes of serum APN, insulin, CRP, leptin, insulin antibody and glutamic acid decarboxylase antibody (GAD-Ab) levels after one year of treatment. Methods: Serum levels of the above four parameters and the positive rate of the two antibodies were measured (with CLIA, ELISA and RIA as appropriately) in 184 patients with type 2 diabetes and 30 controls as well as in 75 patients after one year of treatment. Results: The serum contents of insulin, leptin, CRP, insulin antibody in patients with type 2 diabetes were significantly higher (P<0.01) and APN levels significantly lower (P<0.001) than those in controls. Levels of APN were negatively correlated with those of the other parameters. In the 75 treated patients, levels of those parameters (with the exception of APN and insulin-antibody) decreased significantly. However, the APN levels were significantly increased (vs before treatment, P<0.001). Conclusion: Further study on the dynamic changes of these parameters in the diabetic patients might elucidate certain key-points in the pathogenesis of the disease. (authors)

  18. Perawatan Pulpektomi Secara Singkat Pada Gigi Sulung Nekrotik (Laporan Kasus

    Directory of Open Access Journals (Sweden)

    Sarworini Bagio Budiardjo

    2015-10-01

    Full Text Available Perawatan pulpektomi gigi sulung nekrotik akibat atrisi, trauma atau karies yakni pembuangan seluruh jaringan pulpa nekrotik dan menggantikannya dengan bahan pengisi yang padat, dapat diresorbsi serta tampak secara radiografis. Tujuannya antara lain untuk mempertahankan gigi sulung sampai saatnya digantikan dengan gigi tetap pengganti. Perkembangan, anatomi dan histologi gigi sulung membedakan teknik perawatan pulpektomi gigi sulung dan gigi tetap.Indikasinya adalah gigi sulung nekrotik tanpa peradangan periapikal, mahkota mendukung sterilisasi dan dapat direstorasi serta resorbsi akar fisiologis kurang dari sepertiga akar.Kesulitan perawatan terutama karena bentuk saluran akar yang sangat bervariasi dan resorbsi akar yang tidak beraturan. Tahap perawatan terdiri dari persiapan gigi, sterilisasi, pengisian dan restorasi.Keempat tahap dapat diselesaikan dalam satu kali kunjungan.Pada keadaan dimana terjadi kesulitan persiapan gigi, maka tindakan pengisian saluran akar dan restorasi ditunda 1 minggu kemudian, sehingga perawatan pulpektomi diselesaikan dalam 2 kali kunjungan.Dalam laporan kasus, perawatan pulpektomi dilakukan pada gigi insisif dan molar sulung dengan teknik 1-2 kali kunjungan.Sebagai bahan sterilisasi saluran akar digunakan formokresol dan bahan pengisi campuran zinkoksid-eugenol.  

  19. Coordination of joint actions in Muriaé’s (MG clothing lpa / Coordenação das ações conjuntas no APL de vestuário de Muriaé-MG

    Directory of Open Access Journals (Sweden)

    Cecilia Alves da Silva Antero

    2016-06-01

    Full Text Available Purpose: It sought to understand the coordination of the local production arrangement (LPA, especifically clothing production in the City of Muriaé, MG-Brazil. Originality/gap/relevance/implications: This study proposes the analytical model for comprehending how coordinating happens, as well as indicate relations between the elements that compose it, and the implications for the way in which these elements are manifested in a LPA context. It consists in an advance for understanding governance in LPA. We suggest means for systematizing the coordination of joint actions and mitigating challenges regarding means of production and means of coordinating. Key methodological aspects: A qualitative/descriptive research was performed, whose data was gathered through documents and partially structured interviews, conducted with twenty agents of said LPAs. The data was processed through NVivo® software and categorized by the content analysis technique. Summary of key results: It was found that the coordination is characterized by low levels of formality, integration and participation of the business representatives, management structure made of some entities and average integration and participation levels of the business representatives’ part. Results that support other studies developed about the practice. Key considerations/conclusions: It was identified factors that allow us to grasp the complex reality and dynamics of a LPA, as well as criteria for systematizing and comprehending how coordination happens and pointing out its implication in the development [of local business]. Out of strategies devised, it will be possible to direct the activities of coordinators from others LPAs, fostering local business development Objetivo: Buscou-se compreender a coordenação do arranjo produtivo local (APL de vestuário de Muriaé-MG.Originalidade/Lacuna/Relevância/Implicações: Este estudo contribui ao propor o modelo analítico para compreender a coordena

  20. KEPASTIAN HUKUM DALAM PELELANGAN OBJEK HAK TANGGUNGAN SECARA ONLINE

    Directory of Open Access Journals (Sweden)

    Begiyama Fahmi Zaki

    2017-03-01

    Full Text Available Abstract an auction object the formal use of mortgage online in KPKNL arranged in Article 54 paragraph (3 Minister of Finance Regulation Number 106/PMK.06/2013 that the supply of indirect in writing can be done via email or the internet. The auction the object a mortgage via email done through the application of auction email (ALE, both in terms of registration prospective bidders and documents should be equipped with the determination of the winning bidder performed on these applications. Legal certainty in this case that is at the time of the registration process bidders up to set the winning bidder through ALE. This strengthens with the Law Number 11 of 2008 on information and electronic transaction, where Article 5 paragraph (1 described that information electronically and/or document electronic and/or result print is a legal evidence legitimate. The principle of legal certainty of the opinion that an auction had been conducted by KPKNL for the legal protection to parties concerned to an auction. This is in accordance with rights legislation are explained that when debtors injured promise, the holder the mortgage over its own power has the right to sell by auction common. Implementing auction made treatise auction by officials an auction is a certificate authentic in accordance with Article 1867 and 1868 the book the Act of Civil Law. Treatise auction used the seller/the owner goods, buyers and officials auction to maintain and carry out their rights and duties and have the power of perfect in accordance with Article 1 the 32 Minister of Finance Regulation Number 106/PMK.06/2013. Key words: Legal Certainty, The Protection of the Law, Auction, Mortgage Object, Online Volume Abstrak Penggunaan resmi obyek lelang hipotek secara online di KPKNL diatur dalam Pasal 54 ayat (3 Peraturan Menteri Keuangan Nomor 106/PMK.06/2013 yang pasokan tidak langsung secara tertulis dapat dilakukan melalui email atau internet. Lelang objek hipotek melalui email

  1. Analysis of the variation levels of APN, insulin, sensitive C-reactive protein and leptin in the serum of patients with type 2 diabetes mellitus

    International Nuclear Information System (INIS)

    Du Tongxing; Wang Zizheng; Wang Shukui; Qi Shaokang; Tao Xiaojun

    2005-01-01

    To study the mechanism of pancreatic 13 cell dysfunction and tissue resistance to insulin, and to provide basis for early diagnosis and therapy of the disease, the levels of APN, insulin, sensitive C-reactive protein and leptin in the serum of patients with type 2 diabetes mellitus were determined. Altogether 184 untreatea type 2 diabetes mellitus patients, 30 normal people as the control group, and another 75 type 2 diabetes mellitus patients who have been treated for a year were enrolled in this study. The serum levels of the above indexes were determined by chemiluminescence immunoassay, enzyme immunoassay and radioimmunoassay. The results showed that there were obvious differences in the levels of insulin, leptin, C-reacting protein and insulin antibody between the normal control group and the group of the untreated type 2 diabetes mellitus patients (P<0.01), especially there was significant difference in the level of APN(P<0. 001). Among the 75 type 2 diabetes meltitus patients who have received a year's treatment, all the indexes except for APN and insulin antibody were decreased statistically, while the APN level was increased significantly (P<0.01) than that before the treatment. The determination of markers of type 2 diabetes mellitus is of great significance for its early diagnosis, therapy, prognosis and mechanism research. (authors)

  2. DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis.

    Science.gov (United States)

    Reinhold, Dirk; Bank, Ute; Täger, Michael; Ansorge, Siegfried; Wrenger, Sabine; Thielitz, Anja; Lendeckel, Uwe; Faust, Jürgen; Neubert, Klaus; Brocke, Stefan

    2008-01-01

    Multiple sclerosis (MS) is the most frequent demyelinating disease of the central nervous system. Peptidases like dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) play a regulatory role in T cell activation and represent potential targets for the treatment of inflammatory disorders. Synthetic inhibitors of DP IV and/or APN enzymatic activity induce production of the immunosuppressive cytokine TGF-beta1 and subsequently suppress DNA synthesis and Th1 cytokine production of activated human T cells. Compelling evidence has demonstrated that IL-17-producing CD4 cells (Th17) are a major contributor to the pathogenesis of autoimmune inflammation. Here, we report that inhibitors of DP IV-like activity as well as of APN activity inhibit IL-17 production in activated human and mouse T cells. Combining inhibitors of DP IV and APN increases the suppressive effect on T cell specific IL-17 production in vitro compared to a single peptidase inhibitor. In the following, we summarize the evidence for the role of both ectoenzymes in T cell activation in vitro and in vivo and provide a rationale for the use of combined or dual ectopeptidase inhibitors to treat autoimmune diseases like MS.

  3. Ekstraksi Kata Dasar Secara Berjenjang (Incremental Stemming Berbasis Aturan Morfologi untuk Teks Berbahasa Indonesia

    Directory of Open Access Journals (Sweden)

    Wahyu Hidayat

    2017-05-01

    Full Text Available Ekstraksi kata dasar atau stemming pada Bahasa Indonesia adalah proses yang kompleks di mana beberapa partikel awalan dan beberapa partikel akhiran dari 13 awalan, 3 sisipan dan 19 akhiran yang dikenal dapat digunakan secara sekaligus pada sebuah kata. Selain itu, proses stemming tidak selalu menghasilkan 1 kata dasar (non-deterministik, karena terdapat beberapa kata dalam bahasa Indonesia yang memiliki 2 kemungkinan yaitu sebagai kata dasar maupun kata berimbuhan, misalnya pada kata “beruang”. Penelitian yang telah ada sebelumnya menggunakan kombinasi awalan dan akhiran yang tidak mungkin dan menerapkan heuristik untuk memilih kata dasar. Dalam penelitian ini diusulkan sebuah metode stemming secara berjenjang di mana berdasarkan urutan tertentu, secara bergantian partikel akhiran dan awalan dilepaskan dari sebuah kata sehingga dihasilkan sebuah kata dasar. Jika ditemukan beberapa kandidat kata dasar maka salah satu kata dasar akan dipilih. Metode ini diuji pada 6464 dokumen Al-Quran Terjemahan Indonesia dengan menggunakan kamus berukuran 5000 kata yang disampling secara acak dari Kamus Besar Bahasa Indonesia.. Dari 3432 kata unik yang diproses 94,7% kata dasar dapat diekstrak secara langsung dan hanya 5,3% yang perlu diproses lebih lanjut karena kandidat kata dasar yang ditemukan lebih dari satu. Dibandingkan dengan melakukan pemilihan kata dasar secara manual, metode ini dapat  memilih kata dasar yang tepat hingga 79.12%.

  4. A technical and economic evaluation of reverse osmosis nuclear desalination as applied at the Muria site in Indonesia

    International Nuclear Information System (INIS)

    Humphries, J.R.; Davies, K.; Vu, T.D.; Aryono, N.A.; Peryoga, Y.

    1998-01-01

    effects on the other. In co-operation with BPPT of Indonesia, CANDESAL and AECL have performed an evaluation of this nuclear desalination concept to establish the design, performance and economic characteristics of a large scale reverse osmosis seawater desalination plant coupled with a CANDU reactor, operating under conditions appropriate to the Muria site in Indonesia. The results of the evaluation are discussed herein. (author)

  5. Comparative study of radiological assessment impact of nuclear power plant and coal-fired power plant: the atmospheric dispersion factor (χ/Q) in Muria Peninsula, Jepara

    International Nuclear Information System (INIS)

    Umbara, H.; Syahrir; Yatim, S.

    1997-01-01

    The atmospheric dispersion factor (χ/Q) in Muria Peninsula, Jepara was carried out to calculate the exposure dose to public from nuclear power plant and coal-fired plant. The dispersion factor (χ/Q) value was calculated with mathematical model and diffusion equation. Parameter used as the input data was taken from meteorological data of Ujung Watu site within one year (August 1994 - July 1995) to obtain joint frequency distribution data which were the percentage of wind speed and stability class for 16 sector within one year. The results indicated that the highest dispersion factor (χ/Q) within 300 - 700 m radius from point of release is 4.750E-07 - 8.238E-07 second/m 3 for north west direction (author)

  6. Correlation of Element Concentration of Cd, Cr, Co and Sc in Sea Water, Fish and Algae Samples from Beach of Lemahabang Muria

    International Nuclear Information System (INIS)

    Sukirno; Rosidi; Agus Taftazani

    2007-01-01

    The analysis of Cd, Cr, Co, Sb and Sc element in beach environmental samples Lemahabang Muria in the year 2004 has been carried out by using neutron activation analysis (NAA) method. All of heavy metals from sea water (2.0 μg/l) are obviously lower than the threshold value established by SKRI No 51/2004. From the observed data by Excel application of the correlation value (r) shows that between Cd, Cr, Co, Sb and Sc concentrations from dependent variable of sea water about tree independent variable of kerapu fish, green and brown algae shows a highly positive significant correlation (r > 0.92) except element of Sb was sufficiently positive high (r = 0.66). (author)

  7. Radioecologycal study of {sup 239/240}Pu in Bangka Island and Muria Peninsula: Determination of {sup 239/240}Pu in marine sediment and seawater as part of baseline data collecting for sitting of candidates of first Indonesia NPP

    Energy Technology Data Exchange (ETDEWEB)

    Suseno, Heny, E-mail: henis@batan.go.id [Radioactive Waste Technology Center - The Indonesian National Nuclear Energy Agency (Indonesia); Wisnubroto, Djarot S. [The Indonesian National Nuclear Energy Agency (Indonesia)

    2014-03-24

    Radioisotope Pu-239/240 are alpha emitting nuclides important indicators of radioactive contamination of the marine environment. Global fallout is the main source of plutonium in the marine environment. There are very limited study on {sup 239/240}Pu in Indonesia coastal environments. The data of this radioisotopes is needed for baseline data of nuclear power plant (NPP) site candidates both in Bangka Island and Muria Peninsula. Bottom sediments play an important role in radioecological studies of the marine environment because a large proportion of radioactive substances entering the sea is adsorbed over time onto suspended particulate matter and deposited in sediments. Plutonium is particle reactive and deposited in marine sediment. Radioisotope {sup 239/240}Pu was determinated by alpha spectrometry after radiochemical procedure that was performed in both water and marine sediment from Bangka Island and Muria Peninsula. The sediment baseline of concentration {sup 239/240}Pu in Bangka Island and Muria Peninsula were range from 0.013 to 0.021 Bq.kg{sup −1} and 0.018 to 0.024 Bq.kg{sup −1} respectively. The water baseline concentration this isotope were range from 2.73 to 4.05 mBq.m{sup −3} and 2.98 to 4.50 mBq.m{sup −3}.

  8. Pola Penguasaan Tanah Sawah secara Sistem Gilir Ganti pada Masyarakat Hukum Adat Kerinci

    OpenAIRE

    Idris, Isran

    2011-01-01

    Sistem gilir ganti sawah adalah pola penguasaan tanah sawah menurut Hukum Adat Kerinci. Sistem ini memberikan bagi ahli waris perempuan untuk secara bergilir ganti dalam menggunakan atau pemakaiannya guna mendapatkan hasilnya. Adanya sistem ini adalah pengaruh sistem kewarisan yang membedakan antara harta berat dan ringan. Banyaknya peserta dan persilangan gilir ganti sawah mempengaruhi pergerakan sistem dan masa tunggu setiap peserta untuk mendapatkan gilirannya.

  9. Climate and Hydrological Data Analysis for hydrological and solute transport modelling purposes in the Muriaé River basin, Atlantic Forest Biome, SE Brazil

    Science.gov (United States)

    Santos, Juliana; Künne, Annika; Kralisch, Sven; Fink, Manfred; Brenning, Alexander

    2016-04-01

    The Muriaé River basin in SE Brazil has been experiencing an increasing pressure on water resources, due to the population growth of the Rio de Janeiro urban area connected with the growth of the industrial and agricultural sector. This leads to water scarcity, riverine forest degradation, soil erosion and water quality problems among other impacts. Additionally the region has been suffering with seasonal precipitation variations leading to extreme events such as droughts, floods and landslides. Climate projections for the near future indicate a high inter-annual variability of rainfall with an increase in the frequency and intensity of heavy rainfall events combined with a statistically significant increase in the duration of dry periods and a reduced duration of wet periods. This may lead to increased soil erosion during the wet season, while the longer dry periods may reduce the vegetation cover, leaving the soil even more exposed and vulnerable to soil erosion. In consequence, it is crucial to understand how climate affects the interaction between the timing of extreme rainfall events, hydrological processes, vegetation growth, soil cover and soil erosion. In this context, physically-based hydrological modelling can contribute to a better understanding of spatial-temporal process dynamics in the Earth's system and support Integrated Water Resourses Management (IWRM) and adaptation strategies. The study area is the Muriaé river basin which has an area of approx. 8000 km² in Minas Gerais and Rio de Janeiro States. The basin is representative of a region of domain of hillslopes areas with the predominancy of pasture for livestock production. This study will present some of the relevant analyses which have been carried out on data (climate and streamflow) prior to using them for hydrological modelling, including consistency checks, homogeneity, pattern and statistical analyses, or annual and seasonal trends detection. Several inconsistencies on the raw data were

  10. Analysis of Fe, Ca, Ti, Ba, Ce, Zr and La element in the Sea sediment at Muria peninsula by X RF method

    International Nuclear Information System (INIS)

    Sukirno and Sri Murniasih

    2009-01-01

    he analysis of metals (Fe, Ca, Ti, Ba, Ce, Zr and La) in the sea sediment environmental samples at Muria peninsula has been carried out with X-Ray Fluorescence (XRF) method. The aim of this analysis is to know the distribution metals which accommodate the recent environmental data in supporting the license of site and Environmental Impact Assessment (EIA) for the Nuclear Power Plants (NPP). Samples taken preparation and analysis based on the procedures of environmental analysis. The result analysis that contents of mayor elements in 7 sea sediment location of sampling were Ca, Ti and Fe with concentration are (6.74 – 11.69 ) %; (0.74 – 6.89 ) % and (0.45 -1.94 ) % successively; while minor elements were Ba, Ce, Zr and La with concentration are 451.4 – 1331.6 ) mg/kg; (201.8 – 427.3) mg/kg; (192.3 – 338.5) mg/kg dan (171.7 – 298.4) mg/kg. The statistic test result shows that sampling location there is a significant difference all of element with the level significant of 95 %. (author)

  11. Cable TV: Bringing Home Native Speaker to Increase Listening Comprehension of the Students of English Education Department Teacher Training and Education Faculty Muria Kudus University

    Directory of Open Access Journals (Sweden)

    Rismiyanto Nuraeningsih

    2016-07-01

    Full Text Available This study investigated the use of cable TV to increase listening comprehension of the students of English education department of Muria Kudus University. The aims were to find out: (1 the listening comprehension achievement of the students taught by using cable TV, (2 the students’ response towards the teaching of listening comprehension class by using cable TV, and (3 the students’ difficulties when being involved in the listening class taught by using cable TV are. A classroom action research was conducted with three cycles. The data was collected by using test, observation checklist, & a questionnaire. The subject consisted of 29 students joining Advanced Listening class. The findings show that: (a The listening comprehension achievement of the students taught by using cable TV in cycle I, II, & III is fair, (b The students have enthusiasm and seriousness and motivation in joining the class in all cycles, (c In cycle III the students’ difficulties when being involved in the listening comprehension class taught by using cable TV are more and more decreasing. Keywords: Cable TV, Listening Comprehension

  12. The Migration Behaviour of Cesium-137 on the Soils of Muria Peninsula as the Area of Nuclear Power Plant Site's Candidate

    International Nuclear Information System (INIS)

    Ngasifudin; Herry Purnomo; Endro Kismolo

    2002-01-01

    The research on kinetic and migration of Caesium-137 on the soils of Muria Peninsula as the area of Nuclear Power Plant site's candidate have been done. The migration process of cesium in soil is influenced by physical and chemical properties of soil and environment in which the sorption process is occurred. These physics and chemical properties data and radionuclide retardation factor in such area are needed on the study of mathematic models of radionuclide migration. The experiment results are, porosity : 0.479 - 0.566; the water flowrate average : 5.91 x 10 -4 - 4.48 X 10 -2 cm/second; the longitudinal dispersivity : 0.030 - 0.241 cm; the coefficient of longitudinal dispersivity : 4.96 x 10 -5 - 7.69 X 10 -3 cm 2 /second and retardation factor : 2.30 - 3.39. The result of minerals content of soils for the depth 0-30 cm in average is in the range of : for sand 53.17%, for clay 10.48%, for dust 36.37% and moisture 2.58%. (author)

  13. IMPLEMENTASI POPULATION RESIZING ON FITNESS IMPROVEMENT GENETIC ALGORITHM (PROFIGA UNTUK OPTIMASI RUTE KUNJUNGAN PROMOSI UNIVERSITAS MURIA KUDUS BERBASIS ANDROID DAN GOOGLE MAPS API

    Directory of Open Access Journals (Sweden)

    Tri Listyorini

    2016-04-01

    Full Text Available Tim Promosi Universitas Muria Kudus (UMK melakukan kunjungan promosi ke sekolah menengah atas pada setiap tahun. Kunjungan tersebut dilakukan ke sekolah-sekolah menengah atas di wilayah Kudus, Jepara, Pati, Demak, Rembang dan Purwodadi. Untuk memudahkan kunjungan, setiap kunjungan dibatasi sekitar 15 (lima belas sekolah. Namun pada saat melakukan kunjungan, tim tersebut mengalami kesulitan dalam menentukan rute kunjungan sekolah. Hal ini dikarenakan jarak sekolah yang dikunjungi cukup jauh atau memiliki rute yang rumit sehingga menyebabkan waktu kunjungan yang molor dan biaya pengeluaran bahan bakar yang cukup boros. Untuk menyelesaikan masalah tersebut, dikembangkan suatu aplikasi menggunakan metode heuristik algoritma genetika dengan dinamisasi ukuran populasi atau Population Resizing on Fitness Improvement Genetic Algorithm (PRoFIGA. Aplikasi dikembangkan dengan basis android digunakan untuk memudahkan mencari rute kunjungan terpendek bagi tim promosi UMK sehingga waktu kunjungan menjadi efektif dan efisien. Hasil dari penelitian adalah aplikasi berbasis android untuk penentuan rute kunjungan sekolah terpendek menggunakan metode heuristik yang efisien dan efektif yang dikombinasikan dengan Google Maps Application Programming Interface (API untuk display rute kunjungan sehingga lebih memudahkan bagi tim promosi UMK. Kata kunci: optimasi rute kunjungan, algoritma fuzzy evolusi, optimasi rute android.

  14. Efek Antibakteri Ekstrak Daun Mimba (Azadirachta indica A. Juss) terhadap Bakteri Vibrio algynoliticus Secara In Vitro

    OpenAIRE

    Uli Ayini; Siti Harnina B.; Titis Candra Dewi

    2014-01-01

    Budidaya udang windu di Indonesia telah berkembang pesat. Salah satu kendala budidaya udang adalah penyakit Vibriosis yang disebabkan oleh bakteri Vibrio algynoliticus. Tujuan penelitian ini adalah untuk mengetahui efek antibakeri ekstrak daun mimba terhadap bakteri Vibrio algynoliticus. Penelitian ini menggunakan metode dilusi untuk mengetahui efek antibakteri ekstrak daun mimba terhadap bakteri Vibrio algynoliticus secara in vitro. Konsentrasi ekstrak yang digunakan (%) yaitu: 0; 2,5; 5; 7,...

  15. Pola Penguasaan Tanah Sawah Secara Sistem Gilir Ganti pada Masyarakat Hukum Adat Kerinci

    OpenAIRE

    Idris, Isran

    2011-01-01

    Sistem gilir ganti sawah adalah pola penguasaan tanah sawah menurut Hukum Adat Kerinci. Sistem ini memberikan  bagi ahli waris perempuan untuk secara bergilir ganti dalam menggunakan atau pemakaiannya guna  mendapatkan hasilnya. Adanya sistem ini adalah pengaruh sistem kewarisan yang membedakan antara harta berat dan ringan. Banyaknya peserta dan persilangan gilir ganti sawah mempengaruhi pergerakan sistem dan masa tunggu setiap peserta untuk mendapatkan gilirannya.   Kata kunci: sistem gilir...

  16. Analisa Dimensi Website Yang Mempengaruhi Keputusan Konsumen Surabaya Dalam Melakukan Reservasi Hotel Secara Online

    OpenAIRE

    Sosiawan, Marchella; Sandhika, Vicky Violetta

    2016-01-01

    Penelitian ini ditujukan untuk menganalisa dimensi website yang mempengaruhi keputusan konsumen Surabaya dalam melakukan reservasi hotel secara online. Penelitian ini menggunakkan analisa faktor, hasil penelitian menunjukan 8 faktor baru yaitu dimensi Access (1), Safety and Privacy (2), Marketing (3), Navigation (4), Clarity of Information (5), Personalization (6), Service (7), dan Accurancy (8). Sebagai faktor dari dimensi website yang mempengaruhi konsumen untuk melakukan reservasi hotel s...

  17. PERAN AYAH DALAM KEBERHASILAN PROGRAM INISIASI MENYUSUI DINI (IMD PADA BAYI YANG LAHIR SECARA SECTIO CESARIA

    Directory of Open Access Journals (Sweden)

    sestu retno

    2016-11-01

    Full Text Available ABSTRAK Pendahuluan: Persalinan secara Sectio Cesaria (SC merupakan salah satu kendala untuk melakukan Inisiasi Menyusui Dini (IMD.  Kesiapan ibu yang baru melahirkan untuk memberikan ASInya pada bayi yang baru dilahirkan memerlukan adanya persiapan karena ibu mengalami perubahan peran. Pencapaian peran ibu bisa berhasil bila ibu menjadi dekat dengan bayinya dan mendapatkan dukungan dari suami. Peran suami dalam pelaksanaan IMD adalah sangat penting. Keterlibatan suami dalam pelaksanaan IMD ini meliputi pemberian dukungan dan interaksi. Suami merupakan orang terdekat bagi ibu menyusui yang diharapkan selalu ada di sisi ibu dan selalu siap memberi bantuan. Jika ibu mendapatkan kepercayaan diri dan mendapat dukungan penuh dari suami, motivasi ibu untuk menyusui akan meningkat.Penelitian ini bertujuan untuk mengetahui keterlibatan suami mendampingi istri bersalin secara SC dalam pelaksanaan IMD. Metode: Penelitian ini menggunakan jenis penelitian eksplanatif observasional dengan rancangan cross sectional, bertujuan menggumpulkan data responden untuk menjawab issu strategis yang sedang terjadi, yang menyebabkan ibu post SC tidak melaksanakan IMD. Responden sejumlah 282 ibu post SC yang memenuhi kriteria inklusi dan eksklusi. Tempat penelitian ini dilakukan di  ruang operasi (OK  kebidanan rumah sakit Tipe B, yaitu RSUD Jombang dan RSUD Sogaten Madiun. Hasil: Hasil pengujian secara bersama terdapat pengaruh  dari variabel dukungan suami  dan interaksi suami  terhadap pelaksanaan IMD. Hasil pengujian secara individu terhadap variabel dukungan suami  terdapat pengaruh  terhadap pelaksanaan IMD, sedangkan pada variabel interaksi suami tidak terdapat pengaruh terhadap pelaksanaan IMD.  Pelaksanaan IMD dipengaruhi oleh dukungan suami sebesar 3,7%. Diskusi: Ibu yang didukung suami lebih termotivasi untuk melaksanakan IMD kepada bayinya. Kata kunci: persalinan sectio cesaria, Inisiasi Menyusui Dini (IMD

  18. Penerapan Pasal 1320 KUH Perdata terhadap Jual Beli secara Online (E-Commerce

    Directory of Open Access Journals (Sweden)

    Herniwati ,

    2015-07-01

    Full Text Available Pasal 1320 KUHPerdata mengatur tentang syarat-syarat sah perjanjian. Ketentuan Pasal 1320 ini berlaku terhadap perjanjian jual beli secara konvensional dan perjanjian jual beli melalui online (internet Dewasa ini Perjanjian jual beli melalui online sangat diminati oleh kaum muda dan kaum ibu rumah tangga.Transaksi jual beli secara online atau disebut dengan e-commerce yang dilakukan melalui  media elektronik sudah sangat populer. Para pembeli yang akan membeli barang-barang atau jasa yang ditawarkan oleh penjual (pedagang. Dengan perkembangan teknologi informasi ini akan berdampak terhadap perkembangan aturan-aturan hukum yang ada. Atauran hukum yang diatur dalam KUHPerdata mengatur tentang  syarat-syarat perjanjian. Pasal 1320 KUHPerdata mengatur tentang syarat-syarat sah perjanjian. Ketentuan ini juga berlaku terhadap transaksi jual beli secara online. Ketentuan dalam KUHPerdata ini diperkuat  dengan adanya  Undang-Undang Nomor  11 Tahun 2008 Tentang Informasi dan Transaksi  Elektronik yang mengatur tentang transaksi elektronik.Kata Kunci:  Jual Beli, e-commerce

  19. ISOLASI DAN IDENTIFIKASI KHAMIR SECARA MORFOLOGI DI TANAH KEBUN WISATA PENDIDIKAN UNIVERSITAS NEGERI SEMARANG

    Directory of Open Access Journals (Sweden)

    Jumiyati -

    2012-03-01

    Full Text Available Tujuan penelitian untuk mengisolasi dan mengidentifikasi khamir secara morfologi di tanah Kebun Wisata Pendidikan Unnes. Penelitian ini merupakan penelitian eksplorasi yang dilakukan di Laboratorium Mikrobiologi Jurusan Biologi FMIPA Unnes. Populasi penelitian adalah khamir di tanah Kebun Wisata Pendidikan Unnes. Sampel penelitian adalah isolat khamir yang diambil dengan teknik Purposive Sampling yaitu membagi kebun menjadi lima zona dan setiap zona diambil secara acak lima titik pengambilan kemudian dihomogenkan. Sampel dibawa ke Laboratorium untuk dilakukan isolasi, purifikasi dan identifikasi secara morfologi koloni dan sel. Simpulan penelitian ditemukan tujuh isolat khamir dan termasuk ke dalam lima genus yaitu Saccharomyces, Candida, Debaromyces, Brettanomyces dan Saccharomycodes. The purpose of the research was to isolate and to identify morphologically the individually-isolated yeasts from the soil of Biology Educational Garden Semarang State University. The exploration research was conducted in the Microbiology Laboratory Department of Biology, FMIPA Semarang State University. The yeasts were collected using purposive sampling technique in five zones and from each zone five random plots were selected to obtain the samples. Samples were isolated, purified and identified morphologically in terms of the colonies and the cells. Result revealed that seven isolated yeasts from five generas (Saccharomyces, Candida, Debaromyces, Brettanomyces, and Saccharomycodes had been collected from the soil of Biology Educational Garden Semarang State University.

  20. Relação entre hipertensão arterial sistêmica e síndrome da apnéia obstrutiva do sono

    Directory of Open Access Journals (Sweden)

    Cavallari Fransérgio E.M.

    2002-01-01

    Full Text Available Introdução: hipertensão arterial sistêmica (HAS e a Síndrome da Apnéia Obstrutiva do Sono (SAOS são doenças prevalentes na população mundial e, embora despertem interesse na comunidade médica, não têm fisiopatologia e mecanismos pelo qual produzem suas complicações completamente elucidados. A SAOS está cada vez mais relacionada a patologias cardiovasculares, principalmente à hipertensão, que é prevalente em pacientes com SAOS. Objetivo: Em nosso estudo, objetivamos avaliar as alterações encontradas na presença de HAS em pacientes portadores de SAOS. Forma de estudo: Clínico prospectivo randomizado. Material e método: Estudamos uma população de pacientes do Ambulatório de Ronco e Apnéia do HC FMRP - USP, de fevereiro de 1999 a fevereiro de 2002, em um total de 42, sendo 30 (71,42% pacientes homens e 12 (28,58% mulheres, com idades de 21 a 77 anos (média de 45,3, dp = 9,372706, todos com diagnóstico de SAOS confirmado pela polissonografia, divididos em dois grupos de 21 pacientes com SAOS (controle e 21 com SAOS e HAS. Avaliamos as escalas de Epworth, Ronco e Sonolência nos dois grupos, além do uso da polissonografia para estudo objetivo. Resultado: Não encontramos diferença estatística entre os grupos na comparação dos resultados das escalas, mesmo tendo o grupo de hipertensos médias maiores. Ao avaliarmos objetivamente os pacientes com a polissonografia, levando em conta o IDR, há estatística significante (p=0,0326, com os hipertensos apresentando médias maiores. Vendo a proporção nos grupos, há predomínio de pacientes com apnéia moderada e grave entre os hipertensos, e leve entre os do controle. Conclusão: Concluindo, a concomitância entre HAS e SAOS representa fator agravante no grau da apnéia.

  1. Resultados preliminares do tratamento dos pacientes submetidos a radiofreqüência (baixa freqüência, somnoplastia no ronco e apnéia leve do sono

    Directory of Open Access Journals (Sweden)

    Dibbern Ralph S.

    2002-01-01

    Full Text Available Introdução: O ronco afeta 5 a 50% da população tornando-se um problema médico e social importante. O tratamento pode ser com medidas comportamentais, CPAP e cirúrgico. Objetivo: Avaliar os resultados pós-operatórios dos pacientes submetidos à radiofreqüência em palato. Forma de estudo: retrospectivo clínico. Material e método: 28 pacientes submetidos à radio-freqüência em palato, com diagnóstico de Ronco e Apnéia Leve do Sono. Observamos os resultados pós-operatórios através das Escalas de Epworth, Ronco e Sonolência diurna, complicações e percentual de melhora dos sintomas. A análise estatística foi pelo Mann Whytney Test. Resultados: 16 pacientes com melhora subjetiva do Ronco acima de 70% após a cirurgia; 26 pacientes mostraram redução significativa pelas Escalas, com complicações mínimas. Conclusão: Radio-freqüência é um método seguro e eficaz no tratamento do Ronco e Apnéia Leve do Sono. Resultados melhores serão obtidos com avaliação criteriosa pré e pós-operatórias.

  2. RANCANG BANGUN APLIKASI PENGAMBILAN BERITA SECARA OTOMATIS MENGGUNAKAN CONTENT SYNDICATION BERBASIS XML DENGAN PLATFORM MICROSOFT .NET

    Directory of Open Access Journals (Sweden)

    Diana Purwitasari

    2004-01-01

    Full Text Available Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Banyaknya kebutuhan akan informasi di internet menyebabkan penyedia jasa situs berita untuk memberikan berita yang selalu yang terbaru. Salah satu alternatif solusi adalah dengan melakukan content syndication. Content syndication adalah adalah proses dimana suatu isi berita dikirimkan atau disediakan, biasanya dengan biaya tertentu, dari penyedia berita, biasanya disebut originators, ke pasar yang membutuhkan atau subscribers. RSS (Rich Site Summary adalah format yang secara umum digunakan untuk melakukannya. RSS pada dasarnya adalah suatu file yang berada di suatu situs, yang menyediakan informasi tentang isi dari situs tersebut. File tersebut biasa disebut sebagai RSS Feeds dan dapat di ambil dan diolah untuk mendapatkan informasi tentang isi situs tersebut. Dibuat sebuah aplikasi untuk pengambilan situs berita secara otomatis menggunakan content syndication yang memerlukan aplikasi pada proses background untuk mengambil RSS Feeds secara berkala pada komputer yang berfungsi sebagai server. Server yang mengambil berita dari situs penyedia terdiri dari aplikasi yang mengatur konfigurasi berita tersebut, dan sebuah windows service untuk mengambil RSS feeds kemudian mengolahnya secara otomatis. Sedangkan aplikasi

  3. PREPARASI DAN KARAKTERISASI ZEOLIT DARI ABU LAYANG BATUBARA SECARA ALKALI HIDROTERMAL

    Directory of Open Access Journals (Sweden)

    Jumaeri Jumaeri

    2012-01-01

    Full Text Available Preparasi zeolit dari abu layang batubara PLTU Suralaya secara alkali hidrotermal telah dilakukan. Preparasi dilakukan terhadap abu layang yang telah direfluks dengan HCl 1M dan tanpa refluks. Larutan NaOH dengan konsentrasi tertentu ( 1 ; 2 dan 3 M dicampur dengan abu layang batu bara dengan rasio 10 ml larutan tiap 1 gram abu layang, ke dalam tabung Teflon 100 ml dalam suatu autoclave stainless-steel. Autoclave kemudian dipanaskan pada temperature 80-16 oC selama tiga hari. Zeolit sintesis yang dihasilkan selanjutnya diuji secara kualitatif dengan menggunakan Spektroskopi Inframerah, dan Difraksi Sinar-X. Hasil penelitian menunjukkan bahwa aktivasi abu layang dengan proses alkali hidrotermal dapat menghasilkan material yang mempunyai struktur mirip zeolit (zeolit-like. Produk hidrotermal terdiri dari campuran zeolit (Zeolit P, Zeolit Y serta kristal sodalit dan mullit. Pada temperatur 160 oC, diperoleh zeolit dengan kristalinitas lebih tinggi dari pada 100 oC, baik melalui refluks atau tanpa refluks. Karakteristik zeolit yang terbentuk sangat ditentukan oleh kondisi proses, yang meliputi konsentrasi NaOH, waktu, dan temperatur.

  4. Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13)--a novel approach for the treatment of inflammatory bowel disease.

    Science.gov (United States)

    Bank, Ute; Heimburg, Anke; Helmuth, Martin; Stefin, Sofia; Lendeckel, Uwe; Reinhold, Dirk; Faust, Jürgen; Fuchs, Petra; Sens, Bianca; Neubert, Klaus; Täger, Michael; Ansorge, Siegfried

    2006-12-20

    The ectopeptidases Dipeptidylpeptidase IV and Alanyl-Aminopeptidase N, strongly expressed by both, activated and regulatory T cells were shown to co-operate in T cell regulation. Based on the findings that DPIV and APN inhibitors induce the TGF-beta1 and IL-10 production and a suppression of T helper cell proliferation in parallel, and that particularly APN inhibitors amplify the suppressing activity of regulatory T cells, both peptidases represent a promising target complex for treatment of diseases associated with an imbalanced T cell response, such as inflammatory bowel diseases (IBD). The aim of the present study was to analyze the therapeutic potential of DPIV and APN inhibitors in vivo in a mouse model of colitis. Balb/c mice received 3% (w/v) dextran sulphate sodium with the drinking water for 7 days. After onset of colitis symptoms, inhibitor treatment started at day 3. Disease activity index (DAI) was assessed daily, supplemented by histological and immunological analysis. While the DPIV inhibitor Lys-[Z(NO])(2)]-pyrrolidide or the APN-inhibitor Actinonin alone had marked but no significant therapeutic effects, the simultaneous administration of both inhibitors reduced colitis activity in comparison to placebo treated mice, significantly (DAI 4.8 vs. 7.7, pendogenous immunosuppressive mechanisms.

  5. Horta orgânica de ervas medicinais: inclusão social na comunidade da Barra em Muriaé/MG - Brasil

    Directory of Open Access Journals (Sweden)

    José Luiz de Freitas Paixão

    2013-09-01

    Full Text Available Foi implantada uma horta orgânica de ervas medicinais na comunidade da Barra (Muriaé, MG com o objetivo de inclusão social de pessoas carentes ao permitir acesso ao tratamento por fitoterapia. O início das atividades foi em janeiro de 2006, com a escolha das espécies, obtenção de mudas e instalação da horta. As 40 espécies selecionadas, sob manejo agroecológico, eram indicadas com terapêutica aos 25 principais problemas de saúde levantados na comunidade. O formato didático da horta, representando o corpo humano, serviu como referência às indicações de uso de cada espécie. A horta foi mantida até meados de 2012 na Barra e transferida ao IFMURIAÉ, em área de cultivo agroecológico, no Bairro Sofoco, onde se realizam as práticas do curso de técnico em agroecologia. A comunidade da Barra auxiliou desde as primeiras ações, sendo atuante na colheita das plantas medicinais. As plantas coletadas foram levadas a sala anexa à Paróquia local onde se realizou o processamento pós-colheita e o preparo de fitoterápicos. A dispensação dos preparados foi em outra sala cedida pela Paróquia. As formas fitoterápicas disponibilizadas à população foram de uso interno (erva seca, tintura, xarope e externo (creme, gel, pomada, sendo as mais procuradas: gel, tintura e xarope. De 2006 a 2012 foram  32.400 atendimentos, média de 385 pessoas/mês. O sucesso do projeto se reflete no aumento do número de espécies utilizadas, passando de 40 espécies em 2006 para 170 espécies em 2012, dentre elas: alecrim de jardim (Rosmarinus officinalis, alfavaca (Ocimum basilicum, amora (Morus alba, arnica brasileira (Solidago microglossa, calêndula (Calendula officinalis, camomila (Matricaria chamomilla, capim gordura (Melinis minutiflora, cavalinha (Equisetum arvense, chapéu-de-couro (Echinodorus grandiflorus e espinheira santa (Maytenus aquifolium.

  6. IMPLEMENTASI ALGORITMA MONTE CARLO PADA SISTEM INFORMASI PENERIMAAN PESERTA DIDIK BARU (PPDB SECARA ONLINE

    Directory of Open Access Journals (Sweden)

    Muhammad Rizki Irwanto

    2017-08-01

    Full Text Available Tujuan penelitian ini untuk mengimplementasikan algoritma pada sistem in­formasi Penerimaan Peserta Didik Baru (PPDB secara online.Metode penelitian yang digunakan dalam pengembangan sistem informasi ini adalah metode pe­ngem­bang­an Waterfall. Tahap-tahap dalam metode pengembangan Waterfall, ada­lah: (1 de­finisi kebutuhan sistem, (2 desain sistem dan perangkat lunak, (3 im­ple­men­tasi dan pengujian unit, (4 integrasi dan sistem, dan (5 operasi dan pemeliharaan. Hasil uji coba sis­tem informasi oleh ahli rekayasa web dan admin sebesar 100,00%. Data hasil uji coba sistem informasi oleh guru sebesar 84,10%. Sedangkan data hasil uji coba sis­tem informasi oleh siswa sebesar 87,20%. Dari  data hasil uji coba di atas, dapat di­sim­pulkan bahwa sistem informasi ini sudah valid dan siap digunakan di sekolah.

  7. APLIKASI MONITORING PRAKTEK KERJA LAPANGAN SECARA ONLINE (STUDI KASUS JURUSAN TEKNIK ELEKTRO POLITEKNIK NEGERI BALI

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    Sri Andriati Asri

    2017-12-01

    Full Text Available Mahasiswa Politeknik Negeri Bali melaksanakan Praktek Kerja Lapangan (PKL selama tiga bulan. Selama PKL mahasiswa diwajibkan untuk melaksanakan bimbingan dengan dosen pembimbing PKL. Dalam hal ini, jarak dan waktu menjadi kendala utama yang dialami mahasiswa PKL. Pengelolaan PKL yang telah berjalan selama ini ditangani oleh seorang koordinator. Pengelolaan  tersebut masih dilakukan secara manual, sehingga membutuhkan waktu yang lama dan rawan terjadi kesalahan. Untuk mengatasi hal tersebut peneliti mengembangkan sebuah aplikasi online bimbingan dan monitoring PKL. Aplikasi ini diharapkan mampu mengatasi kendala jarak dan waktu pada proses bimbingan dan membantu koordinator kegiatan PKL untuk membantu pengelolaan dengan lebih baik. Aplikasi dibuat dengan menggunakan metode waterfall, dengan PHP 5.6 dan MYSQL 5.6 sebagai bahasa pemrograman dan basis data. Aplikasi ini telah diujicoba ke pengguna dan dari hasil kuesioner diketahui 17,5% responden sangat setuju dan 82,5 % responden setuju bahwa aplikasi ini sangat membantu.

  8. PEMBAGIAN TUGAS DALAM KOLONI ROBOT OTONOM BERGERAK PADA STUDI KASUS PEMBENTUKAN POLA FORMASI SECARA GRADUAL

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    Wisnu Jatmiko

    2012-05-01

    Full Text Available Pada penelitian ini dilakukan suatu eksperimen pembentukan formasi pola dengan menggunakan Robot LEGO Mindstorms NXT. Pembentukan pola ini dilakukan secara bertahap dimulai dari pembentukan formasi pola yang lebih sederhana menuju kepada formasi pola yang lebih kompleks. Dalam penelitian ini, diterapkan konsep pembedaan peranan dalam pembentukan formasi pola poligon. Konsep pembedaan peranan ini diterapkan dengan menggunakan persamaan periodik. Selain itu, persamaan pembedaan peranan dibuat dengan fitur terbebas dari kondisi awal dari nilai variabel pembeda. Pembentukan formasi pola pada penelitian ini dilakukan dalam 3 tahapan, yaitu tahap penerapan persamaan, tahap penerapan robot simulasi, dan tahap penerapan perangkat robot. Pembentukan formasi pola yang dilakukan pada penelitian ini ada tiga macam, yaitu pembentukan formasi pola segitiga, pembentukan formasi pola segiempat / jajaran genjang, dan pembentukan formasi pola segilima.

  9. PENGEMBANGAN APLIKASI MANAJEMEN PROYEK SECARA GRAFIS BERBASIS WEB MENGGUNAKAN METODE DIAGRAM PRESEDENSI

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    Suhadi Lili

    2004-07-01

    Full Text Available Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Dalam kegiatan manajemen proyek diperlukan koordinasi yang bagus dan kerjasama tim yang kompak antar divisi pelaksana proyek. Selama ini, secara kovensional untuk membuat perencanaan proyek maupun melakukan review dan evaluasi jalannya proyek, perlu diadakan rapat atau pertemuan langsung dari orang-orang yang berperan sebagai manajer dan perencana. Para manajer profesional ini seringkali adalah orang-orang yang mobilitasnya tinggi sehingga tidak selalu berada ditempat pada saat dibutuhkan, sehingga koordinasi proyek akan terhambat dan menjadi tidak efisien. Dengan adanya kemajuan teknologi pada saat ini khususnya internet, permasalahan tersebut sangat memungkinkan untuk diselesaikan dengan menyediakan perangkat lunak yang dikhususkan untuk manajemen proyek, yang bisa diakses online secara multiuser dengan pendekatan sifat real time sehingga para manajer dapat melakukan kolaborasi kerja di mana saja mereka berada selama tersedia perangkat komputer yang terhubung dengan internet. Penelitian ini bertujuan untuk membuat perangkat lunak tersebut. Dalam Teknik Informatika, aplikasi seperti ini merupakan aplikasi terdistribusi, karena itu idealnya harus dibuat bersifat portabel agar dapat berjalan pada semua sistim

  10. Pembuatan Biodiesel Dari Minyak Kelapa Dengan Katalis NaOH Menggunakan Gelombang Mikro (Microwave Secara Kontinyu

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    Daru Satria Prayanto

    2016-04-01

    Full Text Available Biodiesel merupakan bioenergi atau bahan bakar nabati yang dibuat dari minyak nabati melalui proses transesterifikasi, esterifikasi, atau proses esterifikasi-transesterifikasi. Proses pembuatan biodiesel dapat dilakukan dengan metode pemanasan konvensional maupun dengan metode pemanasan microwave. Dengan radiasi microwave, maka waktu yang dibutuhkan saat proses transesterifikasi lebih singkat dibandingkan dengan konvensional. Disisi lain, minyak kelapa memiliki potensi yang besar untuk digunakan sebagai bahan baku dalam pembuatan biodiesel karena ketersediaannya yang melimpah. Penelitian ini bertujuan untuk membuat biodiesel dari minyak kelapa secara kontinyu melalui proses transesterifikasi metanol dengan menggunakan radiasi microwave dengan katalis NaOH dan mempelajari pengaruh konsentrasi tiap katalis, daya, dan laju umpan yang digunakan terhadap yield, densitas, dan viskositas biodiesel yang dihasilkan. Dalam penelitian ini di gunakan 3 variabel, yaitu laju umpan 0,73; 1,25; 1,72 ml/s, konsentrasi katalis 0,25; 0,5; 1 (% berat variabel daya microwave 100, 264, 400, 600, dan 800 Watt. Rasio umpan ditentukan pada 1:9. Pada tahap persiapan melarutkan metanol dan katalis sesuai dengan variabel hingga tercampur homogen. Selanjutnya tahap transesterifikasi dengan mencampurkan larutan metanol (metanol dan katalis dengan minyak kelapa dengan mol ratio yang telah ditentukan dan mengatur daya microwave untuk memulai proses transesterifikasi, proses berlangsung secara kontinyu menggunakan mix flow reaktor. Selanjutnya pemisahan hasil transesterifikasi dari gliserol, dilanjutkan dengan tahap pencucian dengan aquadest untuk memisahkan impurities dan katalis yang masih tersisa dalam biodiesel kemudian memanaskan pada oven untuk menguapkan kandungan air dalam biodiesel. Selajutnya menganalisisa hasil biodiesel terhadap yield, densitas, dan viskositasnya. Hasil terbaik dari variabel yang digunakan di atas adalah pada katalis NaOH dengan konsentrasi 1

  11. PERLINDUNGAN HUKUM TERHADAP ANAK YANG TEREKSPLOITASI SECARA EKONOMI DI KOTA PADANG

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    Laurensius Arliman S

    2016-04-01

    Full Text Available Abstract This paper examines and analyzes the role and constraints of the Department of Social Welfare and Labor of Padang in carrying out child protection economically exploited. This paper uses socio legal research. The results of this paper are: Department of Social Welfare and Labor of Padang has been quite active in implementing the protection of children who are economically exploited, by conducting raids, coaching and training. The obstacles foundwere classic, namely: the nature of the child, the family, the fade of religious values, education, community, economic, cultural shift, the lack of facilities for the development of children, the lack of human resources, and inadequate funds. The author expects that in the future the child is considered by the government of Padang and also by the Child Family and Community. Key words: child, Department of Social Welfare and Labor, economics, padang, exploitation   Abstrak Tulisan ini meneliti serta menganalisis peran dan kendala-kendala Dinas Sosial dan Tenaga Kerja Kota Padang dalam menjalankan perlindungan anak yang dieksploitasi secara ekonomi. Tulisan ini menggunakan penelitian socio legal. Hasil dari tulisan ini adalah: Dinas Sosial dan Tenaga Kerja Kota Padang sudah cukup aktif dalam melaksanakan perlindungan anak yang dieksploitasi secara ekonomi, dengan mengadakan razia, pembinaan dan pelatihan. Kendala yang ditemukan, adalah kendala yang terbilang klasik yaitu: sifat dari anak, keluarga, nilai-nilai agama yang luntur, pendidikan, lingkungan masyarakat, masalah ekonomi, pergeseran budaya, fasilitas pembinaan anak yang kurang, sumber daya manusia yang kurang, dan dana yang kurang memadai. Penulis mengharapkan kedepannya, agar anak lebih diperhatikan oleh Pemerintah Kota Padang serta Masyarakat dan Keluarga anak. Kata kunci: anak, dinsosnaker, ekonomi, padang, eksploitasi

  12. PENGUNGKAPAN KEUANGAN PERKARA SECARA MEMADAI DALAM LAPORAN KEUANGAN SATUAN KERJA PERADILAN

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    Muhammad Anis

    2013-07-01

    Full Text Available Biaya perkara yang dipungut dan dikelola pada Mahkamah Agung dan lembaga peradilan dibawahnya sampai dengan saat ini masih menjadi persoalan terkait transparansi dan akuntabilitas pengelolaan dan penatausahaannya. Berdasarkan Surat Edaran Mahkamah Agung Nomor 09 Tahun 2008 tentang Pelaporan Penerimaan dan Penggunaan Biaya Perkara pada Pengadilan dan Peraturan Mahkamah Agung RI. No. 03 Tahun 2012 tentang Biaya Proses penyelesaian perkara dan Pengelolaannya pada MA dan Badan Peradilan yang berada dibawahnya telah diatur bahwa Biaya Perkara pada pengadilan dalam bentuk agregatditampilkan ke muka publik secara berkala dan dikelola secara efektif, efisien, transparan dan dicatat dalam Catatan atas Laporan Keuangan Mahkamah Agung RI. Berdasarkan Surat Edaran Ketua Mahkamah Agung Nomor 09 Tahun 2008, pelaporan biaya perkara telah berjalan namun belum ditampilkan dalam Laporan keuangan lembaga. Biaya perkara merupakan bagian dari informasi penting yang harus dilaporkan dalam laporan keuangan lembaga sebagai bentuk akuntabilitas lembaga atas biaya yang dipungut dan atau diterima dari pihak ke tiga. Legal fees are collected and maintained by Supreme Court and the courts underneath it so far still an issue related to the management of accounting and reporting. Based on Surat Edaran Mahkamah Agung Nomor 09 tahun 2008 tentang Pelaporan Penerimaan dan Penggunaan Biaya Perkara pada Pengadilan and Peraturan Mahkamah Agung RI. No. 03 Tahun 2012 tentang Biaya Proses penyelesaian perkara dan Pengelolaannya pada MA dan Badan Peradilan yang berada dibawahnyaIn these rules have arranged that legal fees in the court aggregately were published periodically and managed effectively, efficiently, transparency and stored in a note upon the financial report of the supreme court. Based on Surat Edaran Mahkamah Agung Nomor 09 tahun 2008, report of legal fees has been running well but not yet shown in the financial statements of the institution. The legal fees become important

  13. PEMBUATAN ALAT LABORATORIUM FISIKA FAKULTAS ILMU TARBIYAH DAN KEGURUAN IAIN WALISONGO UNTUK PRAKTIKUM OSILASI CAIRAN DAN AYUNAN MATEMATIS SECARA DIGITAL

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    agus sudarmanto

    2016-02-01

    Hasil penelitian ini adalah bahwa pembuatan alat lab- oratorium sika  untuk praktikum osilasi cairan dan ayu- nan matematis secara digital sudah dapat berfungsi sesuai dengan yang diinginkan dan data hasil dari alat tersebut mendekati nilai percepatan gravitasi bumi sebenarnya yai- tu sebesar 9,8 m/s2.

  14. Síndrome da apnéia-hipopnéia obstrutiva do sono. Fisiopatologia Physiopathology of obstructive sleep apnea-hypopnea syndrome

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    Andrea Barral Martins

    2007-02-01

    Full Text Available A fisiopatogenia da apnéia obstrutiva do sono é multifatorial. O sexo, a obesidade, os fatores genéticos, anatômicos e hormonais e o controle da ventilação interagem diversamente na fisiopatogenia e expressão clínica da doença. A obesidade é o principal fator de risco, sendo a elevação do índice de massa corpórea, da gordura visceral e da circunferência do pescoço, fortes preditores de sua ocorrência. A progesterona, por aumentar a atividade dos músculos dilatadores das vias aéreas superiores, tem papel protetor nas mulheres antes da menopausa, justificando a maior prevalência da doença na pós-menopausa, no sexo masculino e na síndrome dos ovários policísticos. Evidências apontam para o fato de que o aumento da idade promove diminuição do tônus muscular, com redução da luz das vias aéreas superiores. O dismorfismo crânio-facial, como na retrognatia ou micrognatia, está associado ao posicionamento posterior da língua, e pode resultar em estreitamento da luz das vias aéreas superiores. Finalmente, comando ventilatório reduzido tem sido detectado em pacientes com síndrome de apnéia obstrutiva do sono e hipercapnia.The physiopathology of obstructive sleep apnea syndrome is multifactorial. Gender and obesity status, as well as genetic, anatomic, and hormonal factors, together with ventilatory drive, interact in a diverse manner in the physiopathology and clinical expression of the disease. Obesity is the main risk factor, since increases in body mass index, visceral fat, and neck circumference are strong predictors of the disease. Progesterone increases the activity of the upper airway dilator muscles and therefore plays a protective role in premenopausal women. This explains the fact that the prevalence of the disease is higher in postmenopausal patients, in patients with polycystic ovary syndrome, as well as in males. Evidence supports the fact that, as individuals grow older, there is a decrease in muscle

  15. Mediasi perbankan dalam kerangka penyelesaian sengketa perbankan secara sederhana, Cepat, dan biaya ringan

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    noor hafidah

    2017-01-01

    Full Text Available Industri perbankan sebagai bagian dari Industri keuangan mempunyai karakteristik yang khusus sebagai lembaga keuangan. Karakteristik khusus tersebut tercermin dalam operasional perbankan yang memiliki fungsi Intermediary, yaitu menghimpun dan menyalurkan dana kepada masyarakat yang dilandasi oleh kepercayaan, serta layanan yang lebih kompleks yang meliputi pembiayaan makro, pembiayaan ekspor impor, transaksi derivatif, fasilitas pembayaran perdagangan internasional (letter of credit dan lain sebagainya.Layanan Perbankan yang sedemikian kompleks dalam prakteknya kadang kala bersentuhan dengan konflik atau sengketa. Sengketa dapat terjadi karena adanya perbedaan pendapat antara bank dengan nasabah mengenai kewajiban dan hak masing-masing, wanprestasi dari nasabah sebagai debitur, tindakan sepihak bank yang dianggap merugikan nasabah, dan sebagainya. Kenyataan demikian menuntut adanya pola penyelesaian sengketa yang efektif dan efisien.Dalam konteks penyelesaian sengketa secara demikian, Bank Indonesia sebagai bank sentral yang memiliki kewenangan dalam menata aktivitas perbankan di Indonesia telah mengeluarkan beberapa peraturan yang terkait dengan mekanisme penyelesaian sengketa, antara lain Peraturan Bank Indonesia Nomor 8/5/PBI/2006 tanggal 30 Januari 2006 dan Surat Edaran Bank Indonesia Nomor 8/14/DPNP tanggal 1 Juni 2006 tentang Mediasi Perbankan.Pasal 1 angka 5 Peraturan Bank Indonesia Nomor 8/5/PBI/2006 menyatakan bahwa mediasi merupakan proses penyelesaian sengketa yang melibatkan mediator untuk membantu para pihak yang bersengketa guna mencapai penyelesaian dalam bentuk kesepakatan sukarela terhadap sebagian ataupun seluruh permasalahan yang disengketakanModel penyelesaian mediasi bagi kalangan perbankan merupakan model yang dianggap tepat karena hubungan bank dan nasabah mengandung kerahasiaan. Kerahasiaan dimaksud adalah kerahasiaan bank sebagaimana tersebut di dalam pasal 40 UU No. 10 tahun 1998 tentang Perbankan. Penyelesaian secara

  16. Efek Antibakteri Ekstrak Daun Mimba (Azadirachta indica A. Juss terhadap Bakteri Vibrio algynoliticus Secara In Vitro

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    Uli Ayini

    2014-03-01

    Full Text Available Budidaya udang windu di Indonesia telah berkembang pesat. Salah satu kendala budidaya udang adalah penyakit Vibriosis yang disebabkan oleh bakteri Vibrio algynoliticus. Tujuan penelitian ini adalah untuk mengetahui efek antibakeri ekstrak daun mimba terhadap bakteri Vibrio algynoliticus. Penelitian ini menggunakan metode dilusi untuk mengetahui efek antibakteri ekstrak daun mimba terhadap bakteri Vibrio algynoliticus secara in vitro. Konsentrasi ekstrak yang digunakan (% yaitu: 0; 2,5; 5; 7,5; 10; 12,5 dan sebagai kontrol terdiri dari kontrol positif, dan kontrol negatif. Pengumpulan data untuk menentukan MIC (Minimum Inhibitory Concentration dilakukan dengan membandingkan kejernihan kultur di medium TSB 2% pada berbagai konsentrasi yang berbeda, dengan kontrol positif dan kontrol negatif. Penentuan MBC (Minimum Bacterisidal Concentration dilakukan dengan melihat ada tidaknya dan jumlah koloni bakteri Vibrio alginolyticus yang muncul pada medium subkultur TSA 2% setelah inkubasi 24 jam. Hasil penelitian menunjukkan nilai MIC yaitu konsentrasi 5%, hal ini ditunjukkan dengan tabung yang mulai jernih. Nilai MBC ekstrak daun mimba terhadap bakteri Vibrio alginolyticus adalah konsentrasi 12,5% ditandai dengan sudah tidak munculnya  koloni bakteri Vibrio alginolyticus. Berdasarkan penelitian ini dapat disimpulkan bahwa ekstrak daun mimba dapat memberikan efek antibakteri terhadap bakteri Vibrio alginolyticus secara in vitro.Tiger shrimp cultivation in Indonesia has been growing rapidly. The main obstacle is the shrimp farming vibriosis disease caused by the bacterium Vibrio algynoliticus. The aim of this research was to determine the effects of neem leaf extract antibakeri against Vibrio algynoliticus. This study used a dilution method to determine the antibacterial effect of neem leaf extract against Vibrio algynoliticus bacteria in vitro. The concentration of the extract used (%: 0; 2.5; 5; 7.5; 10; 12.5 and as a control consisting of a positive

  17. AKTIVITAS ANTIMIKROBA YOGURT BERBASIS AIR KELAPA MENGHAMBAT BAKTERI PATOGEN SECARA IN VITRO

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    Lindawati S. A.

    2014-11-01

    Full Text Available Yogurt merupakan minuman susu yang difermentasi dengan menggunakan bakteri asam laktat Lactobacillus bulgaricus dan Streptococcus thermophyllus sebagai starter. Tujuan penelitian untuk mengetahui kemampuan tertinggi dari yogurt berbasis air kelapa dalam menghambat pertumbuhan bakteri pathogen (Salmonella, Staphylococcus, Klebsiela pneumonia dan E.coli secara in vitro. Penelitian ini menggunakan rancangan acak lengkap (RAL dengan empat perlakuan dan empat ulangan. Keempat perlakuan tersebut: Ko: susu skim 12%+air; K1: susu skim 12%+air kelapa gading; K2: susu skim 12%+kelapa gading bulan; K3: susu skim 12%+air kelapa hijau. Peubah yang diamati adalah aktivitas antimikroba yogurt terhadap bakteri pathogen (Salmonellatyphi, Staphylococcus, Klebsiella pneumonia dan E.coli, total plate count (TPC, total bakteri asam laktat dan E,coli. Hasil penelitian menunjukkan bahwa aktivitas antimikroba tertinggi diperoleh pada yogurt berbasis air kelapa bulan terhadap bakeri Salmonella typhi dan Staphylococcus masing-masing sebesar 0,21 dan 0,26 cm dengan total bakteri asam laktat1,1×107 cfu/mL sedangkan untuk Klebsiella pneumonia dan E.coli diperoleh pada yogurt berbasis air kelapa gading sebesar 0,38 dan 0,64 mm dengan total bakteri asam laktat 3,1×106 cfu/mL.Dari hasil penelitian dapat disimpulkan bahwa yogurt berbasis air kelapa gading, bulan, hijau dan tanpa air kelapa memiliki aktivitas antimikroba berspektrum luas (menghambat bakteri gram positif dan negatif.

  18. Aktivitas Vermisidal dan Ovisidal Daun Biduri (Calotropis Spp. Terhadap Cacing Fasciola Gigantica Secara In Vitro

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    Gilang Kala Maulana

    2015-08-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui aktivitas vermisidal dan ovisidal daun Biduri (Calotropis spp. terhadap cacing F. gigantica. Sampel yang digunakan dalam penelitian ini yaitu telur dan cacing F. gigantica yang diperoleh dari Rumah Potong Hewan Pesanggaran dan daun biduri diambil dari pantai Sanur, Denpasar Bali. Konsentrasi daun biduri dibuat menggunakan daun segar yang dihancurkan dan kemudian dicampurkan dengan cairan empedu untuk vermisidal dan aquades untuk ovisidal. Konsentrasi yang digunakan dalam penelitian ini yaitu 2,5%, 5%, 7,5%, dan 10%. Pengujian dilakukan secara in vitro dengan menggunakan lima perlakuan dan empat kali ulangan. Pengamatan vermisidal dilakukan setiap 30 menit sedangkan untuk ovisidal dilakukan pada hari ke-21 dan ke-28. Hasil dari penelitian didapatkan konsentrasi daun biduri (2,5%, 5%, 7,5%, dan 10% pada masing-masing kelompok perlakuan memiliki pengaruh vermisidal, tidak berbeda nyata (P>0.05 terhadap satu dengan yang lainnya. Efek ovisidal pada hari ke-21 dan ke-28 didapatkan adanya pengaruh yang nyata (P<0.05 terhadap daya hambat tetas telur cacing F. gigantica. Disimpulkan bahwa daun biduri memiliki aktivitas vermisidal dan ovisidal terhadap cacing dan telur F. gigantica. Konsentrasi yang paling efektif untuk vermisidal dan ovisidal terhadap cacing F. gigantica adalah 5%.

  19. PERANCANGAN KENDALI NAVIGASI ROBOT TANK SECARA NIRKABEL BERBASIS SENSOR ACCELEROMETER BERDASARKAN GERAKAN TANGAN

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    Muhamad Yusvin Mustar

    2018-04-01

    Full Text Available Sebuah sistem kendali berbeda pada navigasi robot tank diperkenalkan pada penelitian ini. Umumnya sistem kendali navigasi robot tank dikendalikan meggunakan remot kontrol atau joystick dan beberapa perangkat pengontrolan robot lainya. Pengontrolan navigasi robot tank bertujuan untuk dapat mengendalikan pergerakan robot agar dapat berjalan maju, mundur, berbelok ke kiri dan ke kanan. Pada penelitian ini, pengontrolan navigasi robot dilakukan berdasarkan gerakan tangan manusia. Sebuah sarung tangan yang dilengkapi sensor accelerometer ADXL335 didesain untuk dapat mendeteksi setiap bentuk gerakan tangan. Pendeteksian gerakan tangan didasarkan pada pembacaan orientasi axis X dan Y acceleometer. Gerakan tangan ini kemudian diinput pada mikrokontroler Arduino Nano dan ditransmisikan melalui nRF24L01 2.4GHz. Hasil pendeteksian gerak kemudian diterima dan diolah pada mikrokontroler Arduino Mega yang terdapat pada robot tank. Selanjutnya, hasil pendeteksian gerakan tangan ini dipetakan dalam beberapa bagian pengontrolan, agar sesuai dengan pola pengontrolan navigasi robot tank. Hasil penelitian ini menunjukan bahwa sebuah sistem pengontrolan navigasi robot tank berdasarkan gerakan tangan dapat diimplementasikan dan diaplikasikan secara riil, sehingga dapat memberikan pengalaman baru dalam berinteraksi dengan robot. Kata kunci: navigasi, robot tank, deteksi gerakan, accelerometer ADXL335, arduino, nRF24L01.

  20. Vermisidal dan Ovisidal Ekstrak Daun Pepaya Terhadap Cacing Ascaris suum Secara In Vitro

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    Agung Mourizd Adventus Bili Bora

    2014-05-01

    Full Text Available Tujuan penelitian ini untuk mengetahui vermisidal dan ovisidal dari ekstrak daun pepaya terhadap cacing Ascaris suum. Menggunakan  Rancangan  Acak  Lengkap (RAL, dengan perlakuan beberapa konsentrasi ekstrak daun pepaya 1,5%, 3%, 4,5% dan 6%; kontrol negatif menggunakan NaCl fisiologis dan kontrol positif menggunakan Albendazole 0,12%. Dilakukan uji vermisidal dan uji  ovisidal, uji ovisidal dibagi  menjadi  dua  uji,  yaitu kontak langsung dan kontak tidak  langsung. Untuk uji vermisidal data dianalisis dengan Analisis Probit untuk mengetahui LC100 (Lethal concentration dan LT100 (Lethal  time, sedangkan  untuk  uji  ovisidal  data dianalisis dengan Sidik Ragam dan  jika terdapat perbedaan, dilanjutkan dengan uji jarak berganda Duncan. Hasil  penelitian  vermisidal  didapatkan  LC100 ekstrak  daun  pepaya adalah  3,362%  dan  LT100 39,822  jam.  Untuk  uji  ovisidal  kontak  langsung  dan kontak tidak langsung didapatkan ekstrak daun pepaya berpengaruh sangat nyata (P<0,01 terhadap daya berembrio telur A. suum. Dari hasil penelitian ini disimpulkan bahwa ekstrak daun pepaya efektif sebagai vermisidal dan ovisidal terhadap cacing A. suum secara in-vitro.

  1. UJI AKTIVITAS EKSTRAK DAUN SIRIH (Piper betle L.) SECARA IN VIVO TERHADAP SCABIES PADA KAMBING KACANG (Capra hircus)

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    -, NUR SRIANI REZKI

    2017-01-01

    ABSTRAK Nur Sriani Rezki. O111 12 110, Uji Aktivitas Ekstrak Daun Sirih (Piper betle L.) Secara In Vivo terhadap Scabies pada Kambing Kacang (Capra hircus). Di bawah bimbingan ABDUL WAHID JAMALUDDIN dan MUHAMMAD FADHLULLAH MURSALIM. Kehidupan ternak kambing sering diganggu oleh beberapa penyakit. Salah satu yang disebabkan oleh parasit terutama ektoparasit yang sering dijumpai adalah scabies. Penyakit ini umumnya disebabkan oleh Sarcoptes scabiei. Tujuan penelitian ini untuk menguji akt...

  2. Sistem Pengendali Peralatan Elektronik dalam Rumah secara Otomatis Menggunakan Sensor PIR, Sensor LM35, dan Sensor LDR

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    Eka Desyantoro

    2015-08-01

    Full Text Available Listrik merupakan hal yang sangat penting di kehidupan kita. Setiap pekerjaan kita pasti dibantu dengan adanya listrik. Mulai dari penerangan hingga pengaturan suhu ruangan pun semuanya dibantu oleh listrik. Ketergantungan manusia terhadap listrik ini menimbulkan kebiasaan buruk. Banyak orang yang terkadang membiarkan suatu peralatan elektronik hidup pada saat tidak dibutuhkan. Terjadi suatu permasalahan untuk menciptakan suatu desain sistem embedded untuk mengendalikan peralatan elektronik dalam rumah secara otomatis. Makalah ini membahas tentang perancangan sistem pengendali peralatan elektronik dalam rumah secara otomatis. Sistem terdiri dari sensor PIR yang berfungsi untuk mendeteksi objek bergerak (manusia, sensor LM35 yang berfungsi untuk mendeteksi suhu, dan sensor LDR berfungsi sebagai sensor cahaya. Mikrokontroller ATMega16 sebagai pengendali jalannya sistem dari pembacaan sensor, menampilkan data sensor pada LCD dan mengatur kontak relay untuk menghidup dan mematikan listrik. Sistem pengendali peralatan elektronik dalam rumah secara otomatis menunjukan sensor LDR dapat membedakan gelap dan terang, sensor suhu LM35 dapat mendeteksi suhu dalam ruangan dengan toleransi kesalahan pembacaan kurang lebih 2o Celcius, dan sensor PIR dapat mendeteksi pergerakan manusia sejauh 5 meter.

  3. Alterações cardiovasculares na síndrome da apnéia obstrutiva do sono Cardiovascular comorbidities and obstructive sleep apnea

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    Fátima Dumas Cintra

    2006-06-01

    Full Text Available A síndrome da apnéia obstrutiva do sono (SAHOS é uma condição prevalente na população, associada a maior risco cardiovascular, freqüentemente não-diagnosticada. O reconhecimento da síndrome requer alto grau de suspeita clínica, especialmente por cardiologistas, e pode ser confirmada por meio da polissonografia. O tratamento da síndrome com o uso de CPAP (pressão positiva na via aérea superior é altamente eficaz, melhorando o padrão respiratório durante o sono, instituindo o sono reparador e, dessa forma, otimizando a qualidade de vida desses pacientes, além de atenuar ou reverter muitas das complicações cardiovasculares relacionadas a SAHOS. Este artigo aborda a fisiopatologia e os aspectos clínicos das comorbidades cardiovasculares associadas à síndrome.Obstructive sleep apnea-hypopnea syndrome (OSAHS is a prevalent condition in the general population. It is associated with increased cardiovascular risk and often goes unrecognized. Its diagnose requires a high degree of clinical suspicion, particularly on the part of cardiologists, and it may be confirmed by polysomnography. Continuous positive airway pressure (CPAP therapy is highly effective, since it improves sleep breathing pattern, promotes restful sleep and thus enhances the quality of life of these patients, in addition to attenuating or reversing many cardiovascular complications related to OSAHS. This paper addresses the pathophysiology and clinical features of cardiovascular comorbidities associated with the syndrome.

  4. Pengaruh Penempatan Sirip Berbentuk Segitiga Yang Dipasang Secara Aligned Dan Staggered Terhadap Performansi Kolektor Surya Pelat Datar

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    Ketut Astawa

    2016-07-01

    Full Text Available Abstrak: Energi surya adalah jenis energi terbarukan yang umum digunakan karena ketersediaannya yang sangat besar. Teknologi pengolah energi surya, salah satunya adalah kolektor surya. Kolektor surya pada umumnya, menggunakan laju aliran massa udara yang secara parallel melewati pelat penyerap. Udara yang masuk inlet akan melewati pelat penyerap dan langsung keluar melalui outlet. Penelitian ini dilakukan untuk membandingkan pengaruh penempatan sirip berbentuk segitiga yang dipasang secara alignedyang mengarah ke atas pada bagian atas pelat penyerap dan staggeredyang mengarah ke bawah pada bagian bawah dari pelat penyerap sehingga akan terjadi aliran udara secara turbulen di dalam kolektor dan dengan penambahan sirip segitiga ini juga dapat memperluas daerah penyerapan panas pada pelat penyerap kolektor surya yang secara langsung memperluas permukaan perpindahan panas dari pelat penyerap ke fluida kerja yang nantinya diharapkan mampu menghasilkan temperatur keluar kolektor yang lebih tinggi dan meningkatkan performansi kolektor surya pelat datar.Penelitian ini dilakukan secara eksperimen, sebagai variable bebas dalam penelitian ini adalah intensitas radiasi matahari dan variabel terikatnya adalah energi berguna dan efisiensi kolektor surya pelat datar.Dari hasil pembahasan penempatan sirip berbentuk segitiga pada kolektor surya pelat datar yang dipasang secara staggered menghasilkan energi berguna dan efisiensi yang lebih besar dibandingkan dengan kolektor surya yang dipasang secara aligned. Dilihat dari rata-rata hariannya energi berguna untuk kolektor bersirip aligned adalah 153.01 Watt dan untuk kolektor bersirip staggered sebesar 157.42 Watt, sedangkan untuk efesiensinya pada kolektor surya bersirip aligned adalah 37.94% dan untuk kolektor bersirip staggered42.12 %.Kata kunci : Performansi kolektor surya pelat datar, sirip segitiga aligned, sirip segitiga staggered Abstract: Solar energy is a type of renewable energy that is commonly used

  5. Mapeamento das áreas de risco de inundação com a utilização do modelo digital de elevação hidrologicamente consistente: estudo de caso em Muriaé

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    Nelson Avelar Guimarães

    2009-08-01

    Full Text Available A inundação de áreas urbanas tem sido um grave problema que vários municípios têm enfrentado nos últimos anos, em períodos de chuvas. A ocupação do solo no município de Muriaé - MG, tem-se dado de maneira bastante desordenada e dirigindo-se principalmente para as regiões planas, especialmente para as áreas de inundação do rio Muriaé. A motivação para este estudo surgiu da necessidade de fornecer informações para o processo de tomada de decisão por parte do administrador municipal no sentido de suas políticas públicas. Por esta razão, foi gerado um Modelo Digital de Elevação Hidrologicamente Consistente (MDEHC, a partir de um levantamento planialtimétrico para a caracterização do relevo. De posse do MDEHC foram realizadas simulações, variando altitudes de inundações com o objetivo de determinar quais os bairros que seriam afetados e suas respectivas áreas. Outra análise constitui em realizar a interseção do mapa de imóveis do município com as simulações para determinar o número de residências atingidas pelas inundações simuladas. Os resultados mostraram alta suscetibilidade do perímetro urbano à inundação, em especial o bairro Barra, que para a simulação de uma inundação de 192 metros de altitude, apresentou 27,46% de sua área inundada e cerca de 1440 imóveis atingidos. A metodologia aplicada neste estudo mostrou-ser satisfatória desde que os dados necessários para a caracterização de relevo sejam confiáveis.

  6. Ocorrência de complicações crônicas e seus fatores de risco em pacientes diabéticos atendidos pelo Programa Saúde da Família de Muriaé, MG, Brasil

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    Pedro Paulo Pedrosa NETTO

    2015-01-01

    Full Text Available O objetivo deste trabalho foi analisar a ocorrência de complicações associadas ao diabetes e identificar seus fatores de risco em indivíduos com diabetes mellitus assistidos pelo Programa Saúde da Família de Muriaé-MG. Foi realizado um estudo quantitativo, transversal no período de fevereiro a junho de 2009 na unidade do Programa de Saúde da Família (PSF do bairro São Gotardo no município de Muriaé, MG. A amostra foi constituída por 50 pacientes. As informações de cada participante foram obtidas por meio de um questionário estruturado. As informações sobre a ocorrência de complicações crônicas do diabetes foram obtidas por meio da análise dos prontuários dos pacientes. Foi observado que 23 (46,0% pacientes não apresentavam complicação da doença, enquanto 27 (54,0% apresentavam pelo menos uma complicação, sendo as mais frequentes retinopatia, presente em 18 (66,67% pacientes, doenças cardiovasculares (14, 51,85% e neuropatia diabética (11, 40,74%. Os fatores de risco mais prevalentes foram sedentarismo (39, 78,0%, obesidade central (7, 74,0% e HAS (35, 70,0%. Ainda são necessários grandes esforços na atenção primária ao paciente diabético com relação ao tratamento adequado da doença e à adesão de hábitos de vida saudáveis, pois a presença de complicações associadas ao estado de saúde geral dos pacientes diabéticos diminui significativamente a qualidade de vida desta população.

  7. STATUS INTRODUKSI IKAN DAN STRATEGI PELAKSANAAN SECARA BERKELANJUTAN DI PERAIRAN UMUM DARATAN DI INDONESIA

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    Chairulwan Umar

    2013-11-01

    Full Text Available Masuknya jenis ikan asing berpotensi merubah keseimbangan pada perairan umum daratan, dan di Indonesia gejala ini sudah mulai terlihat. Makalah ini bertujuan untuk membahas lebih lanjut tentang perkembangan introduksi ikan asing, strategi pelaksanaan intoduksi dan berbagai dampaknya terhadap komunitas ikan asli perairan di Indonesia. Penelitian dilakukan melalui penelusuran dan studi pustaka tentang: sejarah kegiatan introduksi ikan yang dilakukan ke Indonesia, jenis-ikan introduksi ikan di Indonesia dan kegiatan introduksi ikan yang telah dan dilakukan di Indonesia beserta dampaknya. Verifikasi lapangan dilakukan pada tahun 2011 di beberapa danau dan waduk antara lain Danau Sentani, Danau Kerinci, Danau Matano dan Waduk Riam Kanan. Data yang terkumpul ditabulasi dan dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa introduksi ikan asing dilakukan di Indonesia sebelum tahun 1900. Introduksi ikan yang telah dilakukan selama ini, lebih banyak dilakukan tanpa melalui kajian ilmiah yang mendalam dan telah terbukti mengakibatkan hilang atau berkurangnya populasi ikan asli atau endemik serta menjadi agen pembawa penyakit. The entry of alien fish species could potentially change the balance of the inland waters and in Indonesia this symptoms was shown. The paper aims are to discuss more about the development introduction of alien fish species, the introduction implementation strategy and its impact to indigenous fish species communities in Indonesian inland waters. The study was conducted through a literature research about: the history of fish introductions activities which carried out in Indonesia, the species of fish introduction in Indonesia and the activities of introduction fish that have been conducted in Indonesia and its impact. Field verification was conducted in 2011 at several lakes and reservoir such us: Sentani Lake, Kerinci Lake, Matano Lake and Riam Kanan Reservoir. The collected data were tabulated and analyzed

  8. Kajian Beberapa Tumbuhan Obat Yang Digunakan Dalam Pengobatan Malaria Secara Tradisional

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    Ira Indriaty Paskalita Bule Sopi

    2017-02-01

    tradisional anti malaria yang teruji secara ilmiah. Masih banyaknya masyarakat yang menggunakan pengobatan tradisional untuk penyembuhan penyakit menunjukkan masih kuatnya tradisi masyarakat dalam hal pencaharian pengobatan. Tujuan penulisan adalah untuk menggambarkan tumbuhan obat yang dimanfaatkan dalam pengobatan tradisional anti malaria. Metode dilakukan melalui tinjauan literatur dengan penelusuran dan pengumpulan data dari berbagai referensi mengenai tumbuhan obat yang dimanfaatkan dalam pengobatan tradisional anti malaria. Data yang telah terkumpul kemudian dideskripsikan menjadi suatu informasi yang menggambarkan jenis tumbuhan obat tradisional dan hasil uji tumbuhan obat. Terdapat beberapa tanaman yang diuji yaitu daun pohon kapur (Harmsiopanax aculeatus Harms, buah merah (Pandanus conoideus Lam., benalu mangga (Dendrophthoe pentandra, manggis (Garcinia mangostana Linn., cempedak (Artocarpus champedem, buah sirih (Piper betle (L. R. Br, mundu (Garcinia dulcis Kurz, dan bunga matahari (Helianthus annuus L.. Dari hasil yang diperoleh menunjukan kandungan senyawa aktif yang terdapat pada jenis tumbuhan obat tersebut telah teruji dalam pengobatan tradisional anti malaria.Kata Kunci : Tumbuhan, obat, tradisional, malaria

  9. PRODUK BENANG SUTRA BERKUALITAS MELALUI TEKNIK SERIKULTUR DENGAN PAKAN YANG DIKEMBANGKAN SECARA IN VITRO

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    Faradilla Faradilla

    2018-01-01

    Full Text Available Samarinda woven sarong is typical sarong of Samarinda. This sarong is still using silk spun silk raw material imported from Tiongkok. The development of aquaculture is needed to obtain local silk threads in order to help to reduce production costs in the samarinda silk industry. The high quality mulberry plants are needed to support silkworm cultivation (sericulture. The qualified mulberry plants are obtained by in vitro culture techniques. The objective of this study is to obtain mulberry leaf (Morus Sp free from disease, uniform, and to obtain quality silk threads through sericulture techniques with feeds that were propagated in vitro. The research stages consist of sterilization, Murashige and Skoog (MS media, sub culture, observation of data analysis fund. The design used is Completely Randomized Design with single factor, ie BAP concentration (control, 0.5 mg / l, 1 mg / l and 2 mg / l. Each treatment is repeated 8 times. The results showed that administration of ZPT 2 mg / l at age 4 MST gives the best response for all observed variables. The use of ZPT BAP with various concentrations produces the germination rate, shoot height, number of shoots and number of different leaves. All treatments are unsuccessful in inducing roots. Keywords: in vitro; Murbei; Sericulture Sarung tenun samarinda adalah sarung khas kota Samarinda. Sarung ini masih menggunakan bahan baku sutera jenis spun silk yang diimpor dari Tiongkok. Pengembangan serikultur diperlukan untuk mendapatkan benang sutera lokal. Sehingga membantu mengurangi biaya produksi dalam industri persuteraan samarinda. Tanaman murbei yang berkualitas diperlukan untuk menunjang budidaya ulat sutera (serikultur. Tanaman murbei yang berkualitas diperoleh dengan teknik kultur in vitro. Tujuan penelitian adalah memperoleh daun murbei (Morus Sp yang bebas penyakit dan seragam serta memperoleh benang sutera berkualitas melalui teknik serikultur dengan pakan yan diperbanyak secara in vitro. Tahapan

  10. Pembentukan mother plant Bacopa australis secara In-vitro dan aklimatisasi dalam aquascape air tawar

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    Media Fitri Isma Nugraha

    2017-12-01

    Full Text Available Tanaman air adalah bagian penting dari ekosistem air tawar. Salah satu spesies yang terkenal adalah Bacopa australis. Hobiis aquascape saat ini memiliki ketertarikan tinggi terhadap tanaman air dengan kualitas yang bagus dari setiap spesiesnya. Metode perbanyakan tanaman air tanpa tanah, lahan pertanian dan air perlu dilakukan untuk memenuhi keinginan tersebut. Tujuan dari penelitian ini adalah untuk mendapatkan formula media kultur jaringan dan zat pengatur tumbuh yang tepat untuk multiplikasi dalam perakitan mother plant (tanaman induk Bacopa australis, serta mendapatkan media terbaik untuk aklimatisasi. Media yang digunakan adalah media Murashige dan Skoog (MS A padat dengan perbedaan konsentrasi zat pengatur tumbuh. Perlakuan uji dalam kombinasi zat pengatur tumbuh (a 0,50 mg/L BAP + 0,50 mg/L kinetin; (b 0,50 mg/L BAP; dan (c 0,50 mg/L 2,4-D. Aklimatisasi tanaman induk dilakukan pada berbagai media antara lain 1 pasir silika + pupuk aqua soil amazonia, 2. pasir malang + pupuk aqua soil amazonia, 3 pasir silika + pupuk cair; 4 pasir malang + pupuk. Hasil yang diperoleh, yaitu formula media kultur terbaik untuk multiplikasi tunas tanaman B. australis secara in-vitro adalah media MS (A yang diperkaya dengan 0,5 mg/L BAP + 0,5 mg/L kinetin, sedangkan aklimatisasi terbaik pada media pasir malang + pupuk aqua soil amazonia. Water plant is an important part of freshwater ecosystems. One of the famous species is Bacopa australis. Today, many aquascape hobbyists have a high interest in aquatic plant species that have good aesthetic appearances. To answer this challenge, a new method in-vitro propagation of aquatic plants, planted without soil, agricultural land and water was conducted. The aim of this research was to find the best growth regulator hormon formula and aclimatisation medium, in creating the mother plant Bacopa australis. The medium used was MS (Murashige and Skoog, 1974 with different growth regulator hormon, i.e: (a 0.50 mg L-1 BAP

  11. VISUALISASI DESAIN GEOMETRIK JALAN SECARA 3D BERDASARKAN PERHITUNGAN ALINYEMEN HORISONTAL DAN ALINYEMEN VERTIKAL

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    A. Arif Dwi Nugroho

    2005-01-01

    Full Text Available Highway geometric design is a part of highway planning which focused on physical form planning, so it can fulfil the highway basic function. Highway geometric design consists of horizontal alignment and vertical alignment and each of them has its own calculation. Computer technology developments can produce softwares which is able to help and simplify the calculations of both alignments and the softwares also can produce designs which visualize the calciulation into 2D images. But 2D image is not real enough to imagine the realistic form of the highway. We need 3D visualisation to imagine the realistic highway. This paper explains how the system can produce the 3D visualisation from horizontal alignment and vertical alignment calculations. First, find the highway 3D position in the 3D coordinate. 3D coordinate has three component, x, y and z axis. From horizontal alignment calculation, we get the x and y value and from vertical alignment, we get the z value. After obtaining the 3D position, then the highway design can be drawn. This software can design the highway better because it can simulate the highway wether it is comfort enough to be passed. Abstract in Bahasa Indonesia : Desain geometrik jalan merupakan bagian dari perencanaan jalan yang dititik-beratkan pada perencanaan bentuk fisik sehingga dapat memenuhi fungsi dasar dari jalan. Desain geometrik jalan terdiri dari Alinyemen Horisontal dan Alinyemen Vertikal, dan masing-masingnya memiliki perhitungan tersendiri. Dengan adanya kemajuan teknologi komputer, mampu menghasilkan program komputer yang dapat membantu dan menyederhanakan perhitungan dari masing-masing alinyemen tersebut serta menghasilkan rancangan yang sesuai dengan kaidah yang berlaku, bahkan mampu membuat visualisasi dua dimensi dari rancangan tersebut. Namun visualisasi dua dimensi dirasa kurang mampu memberi gambaran secara nyata bentuk asli dari rancangan geometrik jalan. Oleh karena itu dalam penelitian yang dilakukan ini

  12. KARAKTERISASI DAN EVALUASI POPULASI ABALON Haliotis squamata SECARA MOLEKULER, MORFOMETRIK, DAN BIOLOGI

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    Gusti Ngurah Permana

    2017-10-01

    Full Text Available Abalon merupakan salah satu komoditas penting gastropoda laut. Tingginya permintaan abalon ini mengakibatkan menipisnya stok di alam. Oleh karena itu, upaya keberhasilan budidaya abalon perlu didukung oleh jenis unggul. Indikasi awal suatu jenis unggul dapat dilakukan dengan menganalisis potensi genetik yang dimiliki. Penelitian ini dilakukan dengan analisis gen 16S rRNA, karakter morfolologi, dan biologi dianalisis secara deskriptif dengan metode kajian pustaka. Hasil yang diperoleh menunjukkan keragaman inter populasi Haliotis squamata mendeteksi adanya tujuh haplotipe yang terbagi dalam dua kelompok. Penyertaan H. diversicolor sebagai outgroup dalam pengujian memperlihatkan bahwa populasi H. squamata dari Pulau Bali dan beberapa lokasi di Pulau Jawa berada dalam satu kelompok yang terpisah dengan outgroup. Hasil ini kongruen dengan analisis morfometrik terdapat perkembangan pertumbuhan cangkang yang asimetri pada populasi Banten. Pertumbuhan asimetri merupakan indikasi spesifik untuk populasi Banten atau merupakan gejala abnormalitas yang dapat diakibatkan oleh faktor penurunan kualitas genetik atau lingkungan. Karakter biologi terlihat proporsi daging dan gonad berbeda pada populasi Banten dengan indikasi adanya pertumbuhan asimetri. Rasio gonad dan daging populasi Banyuwangi berbeda nyata (P<0,05 dengan populasi lainnya. Abalone is arguably one of the highly valued and sought-after marine gastropods. However, the over-exploitation of this species has exhausted its wild stock. To overcome this challenge, the culture technique and management of this species must be established and continually improved. One of the ways is through producing superior broodstocks. An initial assessment of a genetically superior broodstock can be done using the potential genetic analysis. This recent research employed the analysis to study the species’ 16S rRNA gene. To complement the study, the morphometric and biological characteristics of the species were

  13. Studi Eksperimental dan Pemodelan Matematika Proses Pengeringan Kakao Dengan Energi Surya Secara Intermitten

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    Haznam Putra

    2014-06-01

    dimulai dari proses fermentasi kakao. Dengan beberapa kali pengujian kakao, diambil hasil salah satu pengujian dimana hasil fermentasi kakao yang telah dicuci kemudian dikeringkan dari kadar air 55,83% menjadi 7,01% yang berlangsung selama tiga hari yakni 22–24 April 2013 dari pukul 07.00 – 17.00 WIB (Intermitten.  Penelitian dilakukan di Laboratorium Solar Energi Jurusan Teknik Mesin Fakultas Teknik Universitas Sumatera Utara Medan yang berada di kota Medan dengan posisi 3.36 °LU – 98.4 °BT, ketinggian di atas permukaan laut 200 meter dan waktu meridian (7 + GMT. Dari hasil percobaan percobaan didapat persamaan model matematika untuk pengeringan kakao secara intermitten, dengan nilai koefisien difusifitas berada pada nilai 1,39 x10-10 – 1,85 x10-10 m2/detik, selain itu kualitas kakao yang dikeringkan lebih baik dari segi warna dan tidak berjamur dibandingkan dengan kakao yang dikeringkan secara langsung dibawah sinar matahari. st1\\:*{behavior:url(#ieooui } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

  14. ANALISIS CFD HAMBATAN LAMBUNG KAPAL TRIMARAN ASIMETRIS FLAT SIDE INSIDE DENGAN VARIASI JARAK ANTAR LAMBUNG SECARA MEMBUJUR

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    Andrew Gibson

    2016-04-01

    Full Text Available Kapal dibuat dengan fungsi sebagai sarana transportasi untuk kebutuhan niaga maupun perang. Saat ini kebutuhan kapal cepat meningkat sehingga diperlukan kapal dengan bentuk multihull, salah satunya adalah kapal Trimaran. Kapal Trimaran merupakan kapal yang mempunyai 3 lambung, yaitu satu mainhull dan dua side-hull atau disebut juga outriggers sehingga mempunyai nilai stabilitas yang tinggi. Untuk itu, perlu dilakukan penelitian lebih lanjut untuk membuat kapal Trimaran yang memiliki hambatan yang kecil sehingga dapat menambah nilai ekonomis dari segi efisiensi mesin dan performa kapal yang baik. Berbagai bentuk badan kapal kemudian dikembangkan untuk mendapatkan desain lambung kapal Trimaran yang paling optimum salah satunya adalah kapal Trimaran flat side inside, yaitu sebuah konfigurasi baru dengan lambung yang memiliki bidang datar atau asimetris di dalam. Penelitian ini bertujuan untuk mendapatkan variasi letak stagger atau jarak antar lambung secara membujur (R/L kapal Trimaran asimetris flat side inside yang menghasilkan hambatan paling kecil dengan menggunakan bantuan software Computational Fluid Dynamics (CFD. Dengan melakukan variasi kecepatan yaitu 12, 14, 16, dan 22 knot dan variasi jarak antar lambung (R/L dimana R merupakan jarak antar lambung secara membujur dan L adalah panjang kapal mainhull, yaitu untuk R/L = 0.1, R/L = 0.2 dan R/L = 0.3  pada ketentuan jarak antar lambung secara melintang (S/L = 0.4 dapat dilihat pengaruh interaksi gelombang terhadap nilai hambatan gelombang kapal Trimaran asimetris flat side inside. Hasil pengujian didapatkan bahwa  model C dengan R/L = 0,3 dan S/L = 0,4 adalah variasi model paling baik dalam tugas akhir ini karena menghasilkan hambatan viscous dan hambatan total        terkecil dengan presentase yang dibandingkan dengan model awal masing-masing 7,137 % dan 24,965 %.

  15. EFEK VITAMIN C DALAM MEDIUM DMEM TERHADAP PERTUMBUHAN SEL PARU-PARU FETUS HAMSTER SECARA IN VITRO

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    Ema Kurnia W,

    2012-09-01

    Full Text Available Penelitian ini dilakukan dengan tujuan untuk mengetahui efek vitamin C dalam medium DMEM terhadap pertumbuhan sel paru-paru fetus hamster secara in vitro dan untuk mengetahui pada konsentrasi berapakah vitamin C dalam medium DMEM yang berpengaruh paling efektif terhadap pertumbuhan sel paru-paru fetus hamster secara in vitro. Penelitian ini merupakan penelitian eksperimental dengan 6 perlakuan dan 2 ulangan. Masing-masing perlakuan tersebut adalah vitamin C dengan konsentrasi 0mM (kontrol, 5mM, 10mM, 15mM, 20mM, dan 25mM. Vitamin C dengan berbagai konsentrasi tersebut ditambahkan ke dalam medium DMEM dan selanjutnya digunakan untuk menumbuhkan sel paru-paru fetus hamster. Sel paru-paru fetus hamster diisolasi dari fetus hamster berumur 2 hari, ditumbuhkan dalam medium DMEM yang sudah ditambah dengan vitamin C dengan berbagai konsentrasi dan diinkubasi dalam inkubator CO2 5% pada suhu 370C selama beberapa hari sampai biakan sel-sel tersebut konfluen. Setelah konfluenbiakan sel diamati persentase konfluen, viabilitas dan abnormalitas sel. Hasil penelitian menunjukkan bahwa vitamin C dengan konsentrasi 0mM (kontrol, 5mM, 10mM, 15mM, 20mM, dan 25mM dalam medium DMEM mampu menghasilkan persentase konfluen berturut-turut 50%, 65%, 72.5%, 82.5%, 87.5%, dan 92.5% dan persentase viabilitas sel sebesar 89%, 94.5%, 94%, 93%, 94%, dan 96.5%. Sedangkan konsentrasi vitamin C yang efektif terhadap pertumbuhan sel paru-paru fetus hamster secara in vitro adalah konsentrasi 25mM.

  16. Dieta hipocalórica e treinamento físico em pacientes com síndrome metabólica e apnéia do sono

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    Cristiane Maki Nunes

    2011-01-01

    INTRODUÇÃO. Estudos anteriores demonstraram que pacientes com síndrome metabólica (SMet) e apnéia obstrutiva do sono (SAOS) apresentam hiperativação simpática e hipersensibilidade quimiorreflexa. Neste trabalho, testamos as hipóteses de que: 1) dieta hipocalórica associada à treinamento físico (D+TF) melhora a sensibilidade quimiorreflexa em pacientes com SMet e 2) Os efeitos da D+TF seriam mais pronunciados em pacientes com SMet+AOS que em pacientes sem AOS (SMet-AOS). MÉTODOS. Vinte e sete ...

  17. PENUNDAAN PEMBERIAN PAKAN ARTEMIATERHADAP PERFORMANSI BENIH IKAN COBIA (Rachycentron canadum YANG DIPELIHARA SECARA TERKONTROL

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    Titiek Aslianti

    2016-11-01

    Full Text Available Upaya kontinuitas produksi benih ikan cobia, Rachycentron canadum telah dilakukan namun besarnya biaya operasional dalam penggunaan artemia sebagai pakan masih menjadi faktor pembatas. Oleh karena itu, perlu dilakukan penelitian penundaan pemberian artemia dengan tujuan untuk mengetahui waktu yang tepat saat awal diberikan artemia sehingga penggunaannya efektif dan efisien. Penelitian dilakukan dengan menggunakan wadah berupa bak fiber (1 m3 berjumlah 9 unit yang diisi telur cobia sebanyak 3.000 butir/bak dan larva dipelihara hingga mencapai ukuran benih (± 3 cm/umur 20 hari. Rancangan penelitian adalah acak lengkap yang terdiri atas 3 perlakuan yaitu perbedaan waktu awal pemberian artemia yakni pada larva (A umur 5 hari; (B umur 10 hari; dan (C umur 15 hari. Masing-masing perlakuan diulang 3 kali. Data pertumbuhan dan sintasan dianalisis menggunakan sidik ragam. Performansi fisik dan perkembangan tulang belakang diamati sebagai data pendukung. Hasil penelitian menunjukkan bahwa pertumbuhan panjang, bobot, ataupun sintasan di antara perlakuan secara statistik tidak menunjukkan perbedaan yang nyata (P>0,05. Namun pemberian artemia pada larva umur 5 hari (perlakuan A menghasilkan pertumbuhan panjang (28 mm dan bobot badan (74,067 mg serta sintasan (12,07% relatif lebih tinggi daripada perlakuan B ataupun C. Penundaan pemberian artemia lebih dari 5 hari justru menghasilkan benih yang bertumbuh lebih lambat dan banyak mengalami kematian. Hasil pengamatan terhadap perkembangan tulang belakang pada semua perlakuan tidak menunjukkan performansi tulang belakang yang abnormal.  The effort to guarantee a sustainable seed production of cobia, Rachycentron canadum have been carried out but the weight of operational cost in the use of artemia as food has been a problem. The aim of the experiment was to describe the exact and effective time for the initial feeding of seed of cobia using Artemia nauplii. Nine concrete tanks with 1 m3 capacity were stocked

  18. MODEL PENYELESAIAN PERSELISIHAN PARTAI POLITIK SECARA INTERNAL MAUPUN EKSTERNAL (The Model of Political Party Dispute Settlement Internally and Externally

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    Tri Cahya Indra Permana

    2016-03-01

    Full Text Available Undang-Undang Parpol mengatur bahwa perselisihan Parpol diselesaikan secara internal oleh Mahkamah Partai atau sebutan lain daripada itu dan secara eksternal oleh Pengadilan Negeri dan Mahkamah Agung. Substansi perselisihan yang final dan mengikat di Mahkamah Partai adalah perselisihan kepengurusan, selebihnya dapat diajukan upaya hukum ke Pengadilan Negeri dan Mahkamah Agung. Di dalam praktek, pengaturan tersebut telah menjauhkan dari rasa keadilan, kepastian hukum dan kemanfaatan, oleh karenanya sebaiknya direvisi yang mana perselisihan PAW, pelanggaran terhadap hak anggota partai politik, penyalahgunaan wewenang,  pertanggungjawaban keuangan, dan atau keberatan terhadap keputusan partai politik (termasuk keputusan untuk tidak memutuskan terhadap sesuatu hal final dan mengikat dengan Putusan MPP. Sedangkan perselisihan kepengurusan dapat diajukan upaya hukum ke Mahkamah Konstitusi. Political parties act stipulates that a political party dispute resolved internally by the Mahkamah Partai or other designation of that and externally resolved by the District Court and the Supreme Court. The dispute substance in Mahkamah Partai which is final and binding is about organization dispute, the other can be settled in District Court and the Supreme Court. In practice, that arrangement makes the decision apart from the sense of justice, legal certainty and utility. Therefore, these rules should be revised so that the regulation of PAW, violations of the rights of members of political parties, abuse of authority, financial liability, or an objection to the decision of political parties (including the decision not to decide on something is final and binding through Mahkamah Partai decision. While the organization disputes can be submitted to the Constitutional Court for legal action.

  19. PENERAPAN PEMBELAJARAN DENGAN PENDIDIKAN MATEMATIKA REALISTIK (PMR SECARA BERKELOMPOK UNTUK MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIS SISWA DI KELAS X SMA

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    Atik Krismiati

    2013-09-01

    Full Text Available Tujuan dari penelitian ini adalah untuk mengetahui peningkatan kemampuan pemecahan masalah matematis serta kinerja siswa. Subyek populasi dalam penelitian ini adalah siswa SMA Aloysius Bandung. Pendekatan yang digunakan dengan PMR. Instrumen yang digunakan terdiri dari: tes kemampuan pemecahan masalah dan aktivitas siswa selama pembelajaran. Secara keseluruhan siswa yang pembelajaran pemecahan masalah dengan metode PMR lebih baik dalam meningkatkan kemampuan pemecahan masalah, yaitu terlihat dengan adanya peningkatan dari siklus I ke siklus II. Kesulitan siswa terutama pada permasalahan dengan aspek argumentasi dan keakuratan. Selain itu kelebihan dari metode ini siswa lebih terlihat menyukai yaitu terlihat dengan antusiasnya mengerjakan tugas-tugas dari guru serta memberi alasan secara geometri, kreativitas, dan generalisasi yang sebagian besar perwujudannya dilakukan oleh siswa sendiri. Berdasarkan respon dan hasil akhir LKS menunjukkan aktivitas, dan kinerja yang lebih meningkatkan untuk setiap siklusnya Kata Kunci : Pendidikan Matematika Realistik, Pemecahan Masalah Matematis     The purpose of this study is to determine the increase in mathematical problem-solving skills as the well as student performance. The population subjects in this study are the high school students Aloysius Bandung . The approach applied is PMR . The used instruments consisted of : problem solving ability testing and students activities during the learning process. Overall, the students who are applying PMR method is better, which is seen from the increasing cycle I to cycle II. The primary students difficulties are on problems with aspects of argumentation and accuracy. However the advantages of this method the students look more enthusiastic in doing the tasks given are by the teachers, and they are also able to give geometrical and creative reasons. Which most of its manifestations are generally made by the students themselves. Based on the response and the

  20. Sleep apnea and REM sleep behavior disorder in patients with Chiari malformations Apnéia do sono e distúrbio do comportamento da fase do sono com REM em pacientes com malformações de Chiari

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    Paulo Sérgio A. Henriques-Filho

    2008-06-01

    Full Text Available BACKGROUND: Chiari malformations (CM may result in the appearance of REM sleep behavior disorder (RBD and sleep apnea syndrome (SAS that can be considered markers of brain stem dysfunction. PURPOSE: To evaluate the frequency of RBD and SAS in patients with CM type I and II. METHOD: Were evaluated 103 patients with CM by means of full night polysomnography. Were scoring different sleep stages, frequency of abnormal movements (through video monitoring and abnormal respiratory events. RESULTS: Of the 103 patients, 36 showed CM type I and 67 CM type II. Episodes of RBD were observed in 23 patients. Abnormal apnea-hypopnea index (AHI was observed in 65 patients. CONCLUSION: The high rate of RBD suggests that this parassomnia and the increased frequency of central sleep apnea episodes, may be considered as a marker of progressive brain stem dysfunction.INTRODUÇÃO: Malformações de Chiari (MC podem gerar o aparecimento de distúrbio comportamental da fase do sono com REM (DCR e síndrome da apnéia do sono (SAS, sugerindo a ocorrência de disfunção do tronco cerebral. OBJETIVO: Avaliar a freqüência de DCR e SAS em pacientes com MC I ou II. MÉTODO: Utilizou-se a polissonografia de noite inteira para a avaliação de 103 pacientes. Classificaram-se as diferentes fases do sono e analisou-se a freqüência de movimentos anormais (monitorada por vídeo e de eventos respiratórios anormais. RESULTADOS: Dos 103 pacientes analisados, 36 eram portadores de MC I e 67 de MC II. Episódios de DCR foram observados em 23 pacientes. O índice de apnéia/hipopnéia foi considerado anormal em 65 pacientes. CONCLUSÃO: A alta freqüência de DCR e o aumento da freqüência de episódios de apnéia central do sono podem ser considerados manifestação de disfunção progressiva do tronco cerebral.

  1. MODEL PERPINDAHAN MASSA PADA EKSTRAKSI SAPONIN BIJI TEH DENGAN PELARUT ISOPROPIL ALKHOHOL 50% DENGAN PENGONTAKAN SECARA DISPERSI MENGGUNAKAN ANALISIS DIMENSI

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    Susiana Prasetyo

    2012-11-01

    Full Text Available Indonesia merupakan salah satu penghasil teh terbesar di dunia. Menurut data dari Deptan 2010, dengan luas lahan sebesar 127712 ha, Indonesia dapat menghasilkan produktivitas teh sebesar 153971 ton/tahun. Namun sayangnya, selama ini pemanfaatan tanaman teh di Indonesia masih terbatas pada pucuk daunnya saja. Bagian tanaman teh yang memiliki kandungan potensial namun belum dimanfaatkan adalah  biji teh, mengandung 26% saponin, 20-60% minyak dan 11% protein. Saponin merupakan salah satu komponen bioaktif yang telah dimanfaatkan sebagai insektisida pembasmi hama pada tambak udang, bahan baku industri deterjen, shampoo, minuman bir, pembentuk busa pada pemadam kebakaran, dan dapat dimanfaatkan pula sebagai pupuk organik. Pada penelitian ini, saponin biji teh diperoleh melalui ekstraksi biji teh pasca pengepresan menggunakan pelarut IPA 50% secara batch di dalam sebuah ekstraktor berkapasitas 2 L. Pengontakan solvent dengan biji teh dilakukan secara dispersi. Pada penelitian ini, rasio massa pelarut terhadap massa umpan diset 20:1; temperatur divariasikan 25-60 oC, kecepatan pengadukan 100-400 rpm, serta ukuran biji teh divariasikan -40+50 mesh s.d -100+200 mesh. Ekstraksi dilakukan hingga tercapai kesetimbangan. Ekstrak yang diperoleh dipekatkan menggunakan rotavapor vakum pada temperatur di bawah 40oC. Ekstrak pekat saponin kasar yang didapat dimurnikan dengan penambahan eter, etanol dan petroleum eter secara bertahap sehingga diperoleh endapan saponin murni yang kemudian dikeringkan menggunakan tray drier pada temperatur 40oC. Pada penelitian ini, model perpindahan massa sederhana dikembangkan untuk menggambarkan proses ekstraksi padat-cair saponin biji teh. Berdasarkan hasil analisis dimensi diperoleh hubungan antara koefisien perpindahan massa volumetrik (kLa pada lapisan antar fasa padat-cair dengan variabel-variabel ekstraksi yang dinyatakan dalam persamaan bilangan tak berdimensi dengan ralat rata-rata 3,7904 %.DIMENSIONAL ANALYSIS FOR MASS

  2. PELACAKAN KEMBALI KONTROL-KONTROL OBYEK PADA PENAMBAHAN OBYEK SECARA DINAMIS BERBASIS VISUAL BASIC STUDI KASUS ANALISA HIRARKI TUGAS

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    Dwi Sunaryono

    2003-01-01

    Full Text Available v\\:* {behavior:url(#default#VML;} o\\:* {behavior:url(#default#VML;} w\\:* {behavior:url(#default#VML;} .shape {behavior:url(#default#VML;} Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Pembentukan HTA(Hierarchical Task Analysis pada dunia nyata dapat menentukan urutan tugas yang harus diselesaikan dan beberapa jalan / cara yang dapat dicapai baik secara horizontal maupun vertikal. Pendekatan HTA dapat dipetakan kedalam logika komputer berupa alur tugas dari setiap obyek di komputer yang membentuk hirarki tugas dari masing-masing obyek yang akan dikerjakan oleh komputer. Pekerjaan ini mirip dengan pembuatan strategi dan kemudian hasilnya terlihat secara visual, sehingga memungkinkan terjadinya refresh engineering tanpa harus melakukan kompilasi program. Pekerjaan tersebut terdiri dari : pembuatan aturan untuk masing-masing obyek dan cara penerjemahannya (interpreter. Setiap obyek yang dibuat diberi urutan tugas yang berkaitan dengan event, property dan method dari suatu obyek yang akan dikerjakan. Perencanaan obyek tersebut tersimpan ke dalam database sehingga untuk pengerjaan akan merefer ke aturan yang ada di database tersebut yang kemudian di load ke memory sama halnya ketika suatu obyek di instanciate.Kontrol-kontrol obyek setelah terbentuk (instance

  3. Perbandingan Daya Hambat Larutan Antiseptik Povidone iodine dengan Ekstrak Daun Sirih terhadap Candida albicans secara In Vitro

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    Septriana Putri

    2015-09-01

    Full Text Available Abstrak Candida albicansb (C. albicans adalah salah satu mikroorganisme penyebab masalah kesehatan reproduksi wanita, yaitu keputihan (fluor albus. Penggunaan larutan povidone iodine dan bahan alam seperti ekstrak daun sirih menjadi pilihan masyarakat sebagai pembersih alat kewanitaan. Tujuan penelitian ini adalah untuk membandingkandaya hambat larutan antiseptik povidone iodine dan ekstrak daun sirih terhadap jamur C. albicans secara in vitro. Penelitian dilakukan terhadap lima isolat jamur C. albicans dengan larutan kontrol akuades.Perlakuan terdiri dari povidone iodine, ekstrak daun sirih dengan konsentrasi 5%, 10%, dan 20%.Hasil penelitian menunjukkan bahwa povidone iodine memiliki daya hambat terhadap C. albicans. Ekstrak daun sirih dengan konsentrasi 5% dan 10% tidak memiliki daya hambat terhadap C. albicans, namun ekstrak daun sirih konsentrasi 20% memiliki daya hambat terhadap C. albicans. Analisis statistik dengan uji ANOVA yang dilanjutkan dengan uji Post-hoc menunjukkan perbedaan bermakna antara daya hambat larutan povidone iodine dan ekstrak daun sirih 20% terhadap kontrol(p < 0.05.Larutan povidone iodine memiliki daya hambat dua kali lebih besar terhadap pertumbuhan C. albicans dibandingkan ekstrak daun sirih 20%. Dari penelitian ini dapat disimpulkan bahwa larutan povidone iodine dan ekstrak daun sirih 20% dapat menghambat pertumbuhan jamur C. albicans secara in vitro. Kata kunci: povidone iodine, ekstrak daun sirih, Candida albicansAbstract Candida albicans (C. albicans is one of the frequent causes of  reproductive health problems in women, namely vaginal discharge (fluor albus. The antiseptic solution, povidone iodine, is still an option to overcome vaginal discharge. The use of natural materials such as betel (Piper betle L. leaves extract also become a popular choice as adouche for women. The objective of this study was to compare the inhibitory activity of povidone iodine solution and betel leaf extract against the growth of

  4. ANALISIS DIAZINON SECARA DIFERENSIAL PULSA VOLTAMETRI DIBANDINGKAN DENGAN KROMATOGRAFI (Diazinon Analysis with Differential Pulse Voltametry Compared to Chromatography

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    Pirim Setiarso

    2011-07-01

    Full Text Available ABSTRAK Telah dilakukan penelitian penentuan diazinon dari sampel tanah pertanian di beberapa kecamatan Kabupaten Nganjuk Jawa Timur menggunakan elektroda kerja tembaga amalgam padat (CuSAE secara diferensial pulsa voltametri (DPV dibandingkan dengan metode kromatografi. 100 g sampel tanah pertanian yang dihaluskan dengan ukuran 100 mesh diekstraksi menggunakan aseton. Ekstraksi dilakukan menggunakan ekstraktror soxhlet dengan 10 kali sirkulasi. Hasil ekstraksi sebagian ditambahkan surfaktan SDS untuk dianalisis secara voltametri menggunakan elektroda CuSAE dan sebagian dianalisis menggunakan kromatografi cair kinerja tinggi (HPLC. Analisis voltametri dilakukan pada pH 3 dengan elektrolit pendukung CaCl 2 menggunakan standar adisi, sedangkan analisis dengan HPLC menggunakan grafik standar. Berdasarkan data voltamogram dan kromatogram yang telah diolah dengan program origin 7.0 menghasilkan perolehan kembali rata-rata diazinon (97.40 ± 1.02 % pada voltametri dan (100.98 ± 7.10 % pada HPLC. Analisis diazinon kedua metode dibandingkan dengan uji t (t hitung = 0.4785 < t tabel = 2.31 sehingga tidak ada perbedaan hasil antara metode voltametri dan HPLC. ABSTRACT The research has been done for determination of diazinon in agricultural soil samples from several districts n Nganjuk, East Java . Solid copper amalgam (CuSAE used  as a working electrode using differential ulse voltammetry (DPV compared with chromatographic method. Around 100 g sample of agricultural soil ith a size 100 mesh was extracted using 100 ml acetone. The extraction was done using extractor oxhlet with 10 times the circulation. A part of the extraction  yield  was  added SDS surfactant for analysis by DPV,  and another part analyzed  by using high performance liquid chromatography (HPLC. Voltammetric analysis carried out at pH 3 with CaCl2 as a supporting electrolyte   using standard addition method, while the analysis by HPLC using calibration curve (standard

  5. Uji Daya Hambat Ekstrak Buah Belimbing Manis (Averrhoa carambola terhadap Pertumbuhan Bakteri Streptococcus pneumoniae secara In Vitro

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    Rita Risandi

    2016-09-01

    Full Text Available AbstrakBuah belimbing manis (Averrhoa carambola merupakan salah satu tanaman Indonesia yang diyakini memiliki khasiat obat. Salah satu manfaat yang dapat diambil dari sari buah belimbing manis (Averrhoa carambola adalah dapat mengobati radang tenggorokan. Radang tenggorokan merupakan salah satu infeksi yang disebabkan oleh bakteri Streptococcus pneumoniae. Tujuan penelitian ini adalah menentukan daya hambat ekstrak buah belimbing manis (Averrhoa carambola terhadap pertumbuhan bakteri Streptococcus pneumoniae  secara in vitro. Metode studi ini ialah eksperimental dengan desain postest only control group design yang dilakukan di Laboratorium Biota Sumatera Universitas Andalas dan Laboratorium Mikrobiologi Fakultas Kedokteran Universitas Andalas dari Agustus sampai Oktober 2014. Hasil penelitian menunjukkan bahwa ekstrak buah belimbing manis (Averrhoa carambola dengan konsentrasi yaitu 5%, 10%, 15% dan 20% tidak memiliki daya hambat terhadap pertumbuhan bakteri Streptococcus pneumoniae.  Hal ini terbukti karena tidak terbentuk zona hambat pada agar darah dan tidak terdapat pengaruh lama kontak ekstrak buah belimbing manis (Averrhoa carambola  terhadap pertumbuhan bakteri Streptococcus pneumoniae secara in vitro. Ekstrak buah belimbing manis tidak memiliki efek antibakteri terhadap pertumbuhan bakteri Streptococcus pneumoniae.Kata kunci: ekstrak buah belimbing manis, Streptococcus pneumoniae, daya hambat Abstract             Star fruit (Averrhoa carambola is a Indonesian plant that is believed to have medicinal properties. One of the benefits that can be drawn from the juice of star fruit (Averrhoa carambola is the ability to treat strep throat. Strep throat is a bacterial infection caused by Streptococcus pneumoniae. The objective of this study was to determine the inhibitory extract of star fruit (Averrhoa carambola on the growth of the bacterium Streptococcus pneumoniae in vitro. This was an experimental  research  with design

  6. Uji Efektivitas Pestisida terhadap Beberapa Patogen Penyebab Penyakit Penting pada Buah Naga (Hylocereus sp. secara In Vitro

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    Ani Widiastuti

    2011-12-01

    Full Text Available Problem caused by pathogen in Dragon Fruit (Hylocereus sp. cultivation became very important because it decreased significantly the quantity and quality of the fruit production. This study aims to determine the effectiveness of some pesticides against pathogens that cause diseases of dragon fruit in several plantations in the DIY (Sleman and Kulon Progo and Central Java (Magelang and Batang. Test of fungicide effectiveness was done in vitro on PDA medium (potato dextrose agar by poisoned food technique. The fungicides were mancozeb 80 %, methyl tiofanat 70 %, copper hydroxide 80 %, chlorotalonil 75 %, mancozeb 64 % + metalaxyl 4 %, mancozeb karbendazim 73.8 % + 6.8 %,benomyl 50 % at a concentration of 1g/L. The bactericides used were streptomycin sulfate 20 % and oxytetracycline 150 AL with each concentration of 1 g/L and 1 mL /L. The results showed that benomyl 50 % was the most effective fungicide to suppress the growth of Fusarium sp. (brown spot, Colletotrichum sp. (anthracnose and Pestalotiopsis sp. (scab, followed by mancozeb 73.8 % +karbendazim 6.8 % and 73.8 % mancozeb. Bactericide which was able to suppress the growth of Erwinia sp. (stem rot was streptomycin sulfate 20 %.   Gangguan patogen pada buah naga (Hylocereus sp. saat ini menjadi masalah penting karena secara signifikan menurunkan kuantitas dan kualitas hasil panen. Penelitian ini bertujuan untuk mengetahui keefektivan beberapa pestisida terhadap patogen penyebab penyakit-penyakit penting pada tanaman buah naga yang ditanaman pada beberapa sentra pertanaman di Propinsi DIY (Sleman dan Kulon Progo dan Jawa Tengah (Magelang dan Batang. Uji keefektivan pestisida dilakukan secara in vitro pada medium PDA (potato dextrose agar dengan metode teknik makanan beracun (poisoned food technique. Fungisida yang dipergunakan adalah mankozeb 80%, tiofanat metil 70%, tembaga hidroksida 80%, klorotalonil 75%, mankozeb 64% + metalaksil 4%, mankozeb 73,8% + karbendazim 6,8%, benomil 50% dengan

  7. PENGARUH 2,4-D TERHADAP HIPOKOTIL DAN KOTILEDON KEDELAI VARIETAS SLAMET YANG DITUMBUHKAN SECARA IN VITRO

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    Iman Budisantoso

    2015-02-01

    Full Text Available Tujuan yang akan dicapai dalam penelitian ini adalah mengetahui pengaruh 2,4-D terhadap pertumbuhan dan perkembangan hipokotil dan kotiledon kedelai varietas Slamet dalam kultur in vitro. Penelitian dilakukan secara eksperimental dengan rancangan percobaan Rancangan Acak Lengkap (RAL, perlakuan yang dicobakan adalah larutan 2,4-D yang terdiri dari 4 level konsentrasi yaitu 0 mg/L; 20 mg/L; 40 mg/L dan 60 mg/L dan masing-masing perlakuan diulang 4 kali. Parameter perkembangan eksplant yang diamati meliputi prosentase pertumbuhan melalui pembentukan kalus maupun proses embriogenesis, waktu tumbuh kalus, berat basah kalus dan jenis kalus yang terbentuk. Hasil penelitian menunjukkan bahwa eksplant hipokotil maupun kotiledon kedelai varietas Slamet yang ditumbuhkan dalam media MS dengan perlakuan 2,4-D 20-60 mg/L tidak menghasilkan kalus maupun tanaman melalui proses embriogenesis, eksplant berwarna coklat dan mati. Setelah perlakuan konsentrasi hormon diubah menjadi 0, 5, 10 dan 15 mg/L, kalus tumbuh pada eksplant hipokotil dengan perlakuan 2,4-D 5 mg/L, sedangkan eksplant kotiledon kalus tumbuh pada media dengan perlakuan 2,4-D 15 µM.

  8. Atualização em síndrome da apnéia obstrutiva do sono na infância Update in obstructive sleep apnea syndrome in children

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    Aracy P. S. Balbani

    2005-02-01

    Full Text Available A prevalência de SAOS em crianças é de 0,7-3%, com pico de incidência nos pré-escolares. Fatores anatômicos (obstrução nasal severa, más-formações craniofaciais, hipertrofia do tecido linfático da faringe, anomalias laríngeas, etc. e funcionais (doenças neuromusculares predispõem à SAOS na infância. A principal causa da SAOS em crianças é a hipertrofia adenotonsilar. As manifestações clínicas mais comuns são: ronco noturno, pausas respiratórias, sono agitado e respiração bucal. A oximetria de pulso noturna, a gravação em áudio ou vídeo dos ruídos respiratórios noturnos e a polissonografia breve diurna são métodos úteis para triagem dos casos suspeitos de SAOS em crianças, e o padrão-ouro para diagnóstico é a polissonografia em laboratório de sono durante uma noite inteira. Ao contrário dos adultos com SAOS, as crianças costumam apresentar: menos despertares associados aos eventos de apnéia, maior número de apnéias/hipopnéias durante o sono REM e dessaturação mais acentuada da oxihemoglobina mesmo nas apnéias de curta duração. O tratamento da SAOS pode ser cirúrgico (adenotonsilectomia, correção de anomalias craniofaciais, traqueostomia ou clínico (higiene do sono, pressão positiva contínua nas vias aéreas - CPAP.The prevalence of OSAS in children is 0.7-3%, with peak incidence in pre-schoolers. It is characterised by partial or complete upper airway obstruction during sleep, causing intermittent hypoxia. Both anatomical (severe nasal obstruction, craniofacial anomalies, hypertrophy of the pharyngeal lymphoid tissue, laryngeal anomalies, etc. and functional factors (neuromuscular diseases predispose to OSAS during childhood. The main cause of OSAS in children in adenotonsillar hypertrophy. The most common clinical manifestations of OSAS are: nocturnal snoring, respiratory pauses, restless sleep and mouth breathing. Nocturnal pulse oximetry, nocturnal noise audio/videotape recording and nap

  9. Sintomas da síndrome de apnéia-hipopnéia obstrutiva do sono em crianças Symptoms of obstructive sleep apnea-hypopnea syndrome in children

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    Paloma Baiardi Gregório

    2008-06-01

    Full Text Available OBJETIVOS: Investigar os sintomas mais freqüentes encontrados em crianças com diagnóstico polissonográfico de síndrome da apnéia-hipopnéia obstrutiva do sono (SAHOS. MÉTODOS: Foram avaliadas 38 crianças consecutivamente encaminhadas ao laboratório do sono com suspeita de SAHOS no período de junho de 2003 a dezembro de 2004. Os pacientes foram submetidos a um questionário pré-sono e a polissonografia. RESULTADOS: A idade média foi de 7,8 ± 4 anos (variação, 2-15 anos, sendo 50% das crianças do sexo masculino. Não apnéicos corresponderam a 7,9% dos pesquisados, distúrbio leve obstrutivo do sono ocorreu em 42,1%, moderado em 28,9% e severo em 22,1%. Observou-se maior freqüência de casos severos de apnéia entre crianças menores de seis anos (idade pré-escolar. Dentre as crianças com SAHOS, os sintomas mais citados foram ronco e obstrução nasal, presentes em 74,3 e 72,7% das crianças, respectivamente. Sonolência excessiva e bruxismo ocorreram em, respectivamente, 29,4 e 34,3% dos casos e doença do refluxo em apenas 3,1%. Agitação das pernas e dificuldade para iniciar o sono foram encontradas em, respectivamente, 65 e 33% dos avaliados. Todas as crianças que apresentaram SAHOS de grau severo tinham queixa de ronco e bruxismo. CONCLUSÕES: Nossos resultados mostraram que os sintomas mais freqüentes em crianças e adolescentes com SAHOS são ronco e obstrução nasal. Além disso, quadros mais graves da SAHOS estão associados à menor faixa etária.OBJECTIVE: To investigate the symptoms most frequently found in children with a polysomnographic diagnosis of obstructive sleep apnea-hypopnea syndrome (OSAHS. METHODS: We evaluated 38 children consecutively referred to the sleep laboratory with suspicion of OSAHS between June of 2003 and December of 2004. The patients were submitted to a pre-sleep questionnaire and to polysomnography. RESULTS: The mean age was 7.8 ± 4 years (range, 2-15 years, and 50% of the children

  10. UJI ZONA HAMBAT EKSTRAK DAUN PUTRI MALU (Mimosa pudica TERHADAP BAKTERI Staphylococcus aureus DAN Methicillin-resistant Staphylococcus aureus (MRSA SECARA IN VITRO

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    Nyoman Ririn Chandrika Sari

    2015-04-01

    Full Text Available Resistensi Staphylococcus aureus dan MRSA terhadap antibiotika spektrum luas mendorong berbagai penelitian untuk menemukan senyawa aktif yang sensitif dan efektif dalam menghambat pertumbuhan bakteri.Penelitian ini bertujuan untuk mengetahui efek penghambatan ekstrak daun putri malu (Mimosa pudica terhadap pertumbuhan bakteri Staphylococcus aureus dan MRSA.Penelitian terhadap aktivitas antimikrobial ekstrak daun putri malu dilakukan dengan metode agar difusi cakram dengan menggunakan metode Kirby-Bauer.Suspensi bakteri disesuaikan dengan standar kekeruhan Mc Farland 0.5. Biakan bakteri dalam cawan petri masing-masing diberikan 6 perlakuan, yaitu kontrol positif (amoxicillin atau vancomycin, kontrol negatif (alkohol, serta ekstrak daun putri malu dengan konsentrasi 25 mcg/ml, 50 mcg/ml, 75 mcg/ml dan 100 mcg/ml. Pertumbuhan Staphylococcus aureus dihambat secara signifikan oleh ekstrak daun putri malu, dengan efek inhibisi pada semua konsentrasi secara signifikan lebih baik dibandingkan dengan kontrol positif (p<0.05. Zona inhibisi Staphylococcus aureus pada konsentrasi 25 mcg/ml adalah 28.86 mm dan telah memenuhi kriteria sebagai antimikrobial sensitif berdasarkan Clinical and Laboratory Standard Institute (CLSI. Inhibisi pertumbuhan MRSA secara signifikan terjadi pada semua konsentrasi ekstrak daun putri malu dibandingkan dengan kontrol negatif (p=0.00. Zona inhibisi terbesar ditemukan pada konsentrasi 100 mcg/ml dengan diameter sebesar 14.16 mm dan memiliki efek antimikrobial sebanding dengan vancomycin dalam menghambat pertumbuhan MRSA (p=0.186. Hasil uji agar difusi cakram menunjukkan bahwa senyawa aktif dalam ekstrak daun putri malu memiliki aktivitas antimikrobial yang tinggi terhadap Staphylococcus aureus dan MRSA secara in vitro.

  11. Audit Secara Prospektif terhadap Antimicrobial Stewardship Program pada Pasien Kanker Payudara di RSUP Dr. M. Djamil Padang

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    Yelly Oktavia Sari

    2017-12-01

    Full Text Available Pembedahan yang digunakan sebagai bagian dari pengobatan kanker payudara memiliki potensi risiko infeksi karena pengaruh flora normal pada tubuh dan udara di lingkungan rawat inap. Keefektifan suatu antibiotik dipengaruhi oleh resistensi bakteri terhadap antibiotik. Tujuan penelitian ini untuk mengetahui pola bakteri, pola sensitifitas antibiotik dan pola penggunaan antibiotik pada pasien kanker payudara di bangsal bedah RSUP Dr. M. Djamil Padang pada bulan April - September 2017. Penelitian ini dilakukan secara prospektif menggunakan metode observasi yang bersifat deskriptif. Pola bakteri pada pasien ditemukan Staphylococcus aureus dan Klebsiella sp. sedangkan pada udara ditemukan bakteri Staphylococcus aureus, Staphylococcus epidermidis dan Klebsiella sp. Berdasarkan pola sensitifitas bakteri terhadap antibiotik  selama bulan April-Mei 2017 maka yang tergolong baik (>80% adalah amoksisilin/asam klavulanat dan meropenem sementara pada bulan Agustus-September 2017 adalah meropenem. Pola sensitifitas bakteri udara selama bulan April-Mei 2017 tidak ditemukan yang tergolong baik sedangkan pada bulan Agustus-September 2017 adalah gentamisin, siprofloksasin dan meropenem. Dari total pasien sebanyak 32 orang, yang memenuhi kriteria inklusi hanya 7 orang pasien. Pola penggunaan antibiotik terbanyak pada pasien adalah seftriakson dengan jumlah 7(77,8% dan terjadi perubahan pola sensitifitas antibiotik seftriakson pada bulan April - Mei 2017 yaitu sensitif (66,7% menjadi (33,3% pada bulan Agustus-September 2017. Evaluasi kerasionalan penggunaan antibiotik, diperoleh 6(66,7% tepat obat, 9(100% tepat dosis, 7(77,8% tepat lama pemberian 9(100% tepat rute,7(100% tepat pasien dan 4(45,1% tepat indikasi serta potensi interaksi obat sebanyak 1(14,3% yaitu potensi minor.

  12. Neurocristopatia no diagnóstico diferencial das apnéias do recém nascido: relato de caso Neurochristopathy in the differential diagnosis of newborn's apnea: case report

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    Magda Lahorgue Nunes

    2001-12-01

    Full Text Available OBJETIVO: incluir a neurocristopatia na investigação etiológica das apnéias refratárias do recém nascido e discutir o valor diagnóstico da polissonografia. MÉTODO: relato de caso e discussão crítica da literatura. RESULTADOS: relatamos o caso de um recém-nascido que apresentou disfunção ventilatória nas primeiras horas de vida associada a distensão abdominal, necessitando de ventilação mecânica contínua com piora do quadro respiratório durante o sono. Após o diagnóstico polissonográfico de hipoventilação foi investigado com exames de neuroimagem e biópsia de cólon, positiva para doença de Hirschprung. CONCLUSÃO: a neurocristopatia é uma síndrome neonatal que por vezes pode ter o seu reconhecimento dificultado pelo amplo espectro clínico associado. A polissonografia foi fundamental nesta investigação confirmando a hipoventilação. Este diagnóstico etiológico deve ser considerado na investigação de recém-nascidos com apnéias persistentes durante o sono.OBJECTIVE: to include neurocristopathy on the etiological workup of neonatal apneas and discuss the importance of polysomnography in this diagnosis. METHOD: case report and critical review of the literature. Results: we report on a newborn that presented respiratory failure in the first hours of life associated to abdominal distention. Continuous ventilatory support was necessary, and the respiratory distress increased during sleep. After polysomnographic confirmation of hypoventilation the newborn was submitted to neuroradiolgic tests and colon byopsy, positive to Hirschsprung's disease. CONCLUSION: Neurocristopathy syndrome can have many different clinical expression, and sometimes the syndrome can be misdiagnosed. Polysomnography confirms central hypoventilation. This diagnosis should be considered in the newborn's persistent apnea workup.

  13. Ronco habitual e apnéia obstrutiva observada em adultos: estudo de base populacional, Pelotas, RS Habitual snoring and obstructive sleep apnea in adults: population-based study in Southern Brazil

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    Ricardo B Noal

    2008-04-01

    Full Text Available OBJETIVO: Estimar a prevalência de ronco habitual e apnéia obstrutiva observada e fatores associados. MÉTODOS: Estudo transversal com amostra representativa de 3.136 adultos, com 20 anos ou mais, residentes em Pelotas, Rio Grande do Sul, em 2005. Informações sobre os desfechos e variáveis demográficas, socioeconômicas, comportamentais e antropométricas foram coletadas por meio de questionário. A análise estatística bruta e ajustada foi realizada utilizando-se teste exato de Fisher ou qui-quadrado de tendência linear e regressão de Poisson, respectivamente. RESULTADOS: A prevalência encontrada de ronco habitual foi de 50,5% (IC 95%: 48,1;52,8 e de apnéia obstrutiva de 9,9% (IC 95%: 8,7;11,2. Na análise ajustada, o relato de ronco foi maior nos homens (Razão de Prevalências - RP=1,25; IC 95%: 1,16;1,34, nos idosos (RP=1,62; IC 95%: 1,46;1,80, nos tabagistas (RP=1,15; IC 95%: 1,07;1,25, nos alcoolistas (RP=1,17; IC 95%: 1,03;1,31 e nos obesos (RP 1,71, IC95% 1,55;1,88. O relato de apnéia obstrutiva foi maior nos homens (RP=2,05; IC 95%: 1,67;2,52, nos idosos (RP=2,23; IC 95%: 1,64;3,03, nos tabagistas (RP=1,60; IC 95%: 1,25;2,05 e nos obesos (RP=2,61; IC 95%: 1,97;3,47. CONCLUSÕES: Ronco habitual e apnéia obstrutiva foram sintomas comuns na população estudada. Fatores de risco conhecidos como sexo masculino e idade entre quarta e quinta décadas de vida não são modificáveis. Entretanto, tabagismo, alcoolismo e obesidade também associados aos desfechos, devem ser identificados e tratados na população geral.OBJECTIVE: To estimate the prevalence of habitual snoring and obstructive sleep apnea and their factors associated. METHODS: Cross-sectional study with a representative sample comprising 3,136 adults (>20 years living in the city of Pelotas, Southern Brazil, in 2005. A questionnaire was used to collect information on demographic, socioeconomic, behavioral and anthropometric variables and outcomes. Crude and adjusted

  14. Karakterisasi Unjuk Kerja Diesel Engine Generator Set Sistem Dual Fuel Solar-Syngas Hasil Gasifikasi Briket Municipal Solid Waste (MSW Secara Langsung

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    Achmad Rizkal

    2017-01-01

    Full Text Available Sejalan dengan semakin banyaknya kebutuhan energi untuk dapat digunakan sebagai bahan bakar maka perlu adanya pengembangan gas biomassa sebagai bahan bakar alternatif pada motor pembakaran dalam maka akan dilakukan penelitian mengenai aplikasi sistem dual fuel gas hasil gasifikasi biomassa municipal solid waste (msw pada sistem downdraft dengan minyak solar pada motor diesel stasioner. Penelitian ini bertujuan untuk mengetahui seberapa besar solar yang tersibtitusi dengan adanya penambahan syngas yang disalurkan secara langsung. Penelitian ini dilakukan secara eksperimental dengan proses pemasukan aliran syngas yang dihasilkan downdraft municipal solid waste (MSW kedalam saluran udara mesin diesel generator set secara langsung menggunakan sistem mixer. Pengujian dilakukan dengan putaran konstan 2000 rpm dengan pembebanan bervariasi dari 200 watt sampai dengan 2000 watt dengan interval 200 watt. Bahwa produksi syngas dari reaktor gasifikasi ditambahkan sistem bypass untuk mengetahui kesesuaian antara reaktor gasifikasi dan mesin generatorset data ṁ syngas yang dibutuhkan mesin diesel, ṁ syngas yang di bypass untuk mendapatkan kesesuaian antara produksi syngas dan yang di bypass.  Data-data yang diukur dari penelitian ini menunjukkan bahwa besar nilai mass flowrate gas syngas yang dibutuhkan mesin diesel pada AFR reaktor gasifier 1,39 sebesar 0,0003748 kg/s. Mass flowrate gas syngas yang di bypass menunjukkan nilai 0 pada saat sistem dijalankan karena seluruh gas syngas masuk kedalam ruang bakar. AFR rata-rata sebesar 14,54 ,Nilai Spesifik fuel consumption (sfc mengalami peningkatan 68% dari kondisi standar single fuel , Nilai efesiensi thermal mengalami kenaikan sebesar 7% dari kondisi single fuel, Nilai daya rata-rata sebesar 2,28kW, Nilai torsi rata-rata sebesar 10,94 N.m. Solar yang tersibtitusi sebesar 48%. Nilai temperatur (coolant, mesin, oil, dan gas buang pada setiap pembebanan mengalami kenaikan.

  15. Model Polikultur Udang Windu (Penaeus monodon Fab, Ikan Bandeng (Chanos-chanos Forskal dan Rumput Laut (Gracillaria Sp. Secara Tradisional

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    Murachman - -

    2012-05-01

    ,157 mgl-1, H2S 0,025 mgl-1, NO2 0,109 mgl-1, PO4-3 0,461 mgl-1, pH 8,05, TOM 38.635 mgl-1, TSS 176,418 mgl-1, alkalinitas 4,665 mgl-1, suhu 32.96 °C, kadar garam 32,5, BOD 2,88 mgl-1 dan kandungan Pb 0,245 mgl-1. Secara kualitatif dan kuantitatif tingkat produksi udang windu adalah (201.11 kgha-1m-1 dan ikan bandeng (1180,56 kgha-1m-1 pada sistem polikultur tiga komoditas lebih tinggi daripada tingkat produksi di sistem polikultur dua komoditas. Secara kuantitatif diketahui bahwa untuk budidaya udang windu kelimpahan plankton adalah 11,466 ekor tiap liter, pertumbuhan absolut 23,93 g, lemak 0,604, tingkat kelangsungan hidup 53% dan rata-rata ukuran tubuh adalah  34 ekor tiap kg. Parameter untuk budidaya ikan bandeng adalah  kelimpahan plankton adalah 69,845 ekor tiap liter, pertumbuhan absolut 354,99 g, lemak 0,604, tingkat kelangsungan hidup 95% dan rata-rata ukuran tubuh adalah 4,25 ekor tiap kg. Keuntungan finansial pada polikultur tiga komoditas adalah Rp. 20.717.628 dan Rp. 11.924.115 pada polikultur dua komoditas untuk tiap hektar tambak pada satu musim tanam.   Katakunci: polikultur, ikan bandeng, komoditas, udang windu     Abstract Polyculture is an alternative to solving water quality problems leading to decrease of fish production in the ponds. The present research is aimed at establishing the management of polyculture of black tiger prawn, milkfish, and seaweed. This study employs method of case study in Dusun Tanjung Sari, Desa Kupang, sub-district of Jabon, Regency of Sidoarjo. Samples were collected from 18 polyculturers of three commodities (black tiger prawn, milkfish, and seaweed and 20 polyculturers of two commodities (black tiger prawn and milkfish by means of proportional sampling. Variables to be investigated were type of commodity, treatment in the polyculture processes, stocking density, water quality, mangrove forest, social and economic institutions, investment and operational funds, production, quality and fertility of water, and financial

  16. バージニア大学における高度専門看護師 (APN) 教育に関する調査報告

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    正木, 治恵; 眞嶋, 朋子; 佐藤, まゆみ; 石井, 邦子

    2008-01-01

    看護学研究科における高度専門職養成教育のあり方を検討するための基礎資料として,米国の高度専門看護師 (APN : Advanced Practice Nurse) 教育に関する調査を行った.情報提供者は同大学院の教員,大学病院における臨床指導者,大学院生であった.調査項目は,バージニア大学大学院教育課程全体の概要,APNの理論的枠組み,老人看護,急性期看護(クリティカルケア,がん看護を含む),助産師教育,NP(Nurse Practitioner)教育およびDNP (Doctor of Nursing Practice) 教育,臨床指導の概要,大学病院におけるAPNの役割の実際についてである.米国では,NP,CNS (Clinical Nurse Specialist), CNM (Certified Nurse-Midwife), CRNA (Certified Registered Nurse Anesthetist) を総称してAPNとし,2年間の修士課程において養成するものとしている.このように統合した経緯には,実践現場でCNSとNPの役割を統合するような能力や役割が求め...

  17. Efektifitas Jahe Merah (Zingiber officinale Var. Rubrum sebagai Additif Pakan dan Antimikrobia terhadap Pertumbuhan Bakteri Anaerob dan Coliform Secara In Vivo pada Ayam Pedaging

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    J.R. Manullang

    2015-10-01

    Full Text Available Jahe merah (Zingiber officinale Var. Rubrum dikenal sebagai bakteriasida. Penelitian ini bertujuan untuk mengetahui aktivitas antibakterial bubuk jahe terhadap pertumbuhan bakteri anaerob dan coliform (Escherichia coli dan Salmonella sp. secara in vivo pada Broiler. Penelitian ini menggunakan dua puluh empat DOC dengan berat badan 40,7 g. Pemberian bubuk jahe diberikan pada Broiler selama 5 hari dengan konsentrasi ekstrak jahe merah yaitu, 0,5, 1, dan 1,5% per kg pakan. Peubah yang diamati adalah berat badan, asupan pakan dan koloni bakteri. Hasil penelitian menunjukkan terdapat pengaruh ekstrak jahe merah pada total koloni bakteri yang cenderung menurun dengan semakin tinggi konsentrasi ekstrak jahe merah, semakin tinggi efek hambatan pertumbuhan bakteri. Dapat disimpulkan bahwa ekstrak jahe merah memiliki sejumlah aktivitas antibakteri untuk pertumbuhan bakteri anaerob dan coliform (E. coli dan Salmonella sp..

  18. PERMODELAN PENGELOLAAN WILAYAH PESISIR DAN PULAU-PULAU KECIL SECARA TERPADU YANG BERBASIS MASYARAKAT (STUDI KASUS PULAU RAAS KABUPATEN SUMENEP MADURA

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    Adi Waluyo

    2013-04-01

    Full Text Available Negara Indonesia adalah negara maritim yang memiliki banyak pulau baik yang bernama maupun yang belum bernama. Salah satunya adalah pulau Raas Madura, dimana pulau ini memiliki sumber daya alam yang melimpah di sepanjang garis pantainya. Dibalik melimpahnya sumber daya alam tersebut masih terdapat masyarakat yang sebagian besar prasejahtera. Pemanfaatan yang berlebih (over exploitation dan krisis ekonomi yang menyebabkan terjadinya persaingan untuk memperoleh sumber daya alam yang tersisa sehingga mengakibatkan terjadinya degradasi sumber daya alam. Sistem pengelolaan wilayah pesisir dan pulau-pulau kecil yang secara terpadu yang dapat mengatisipasi terjadinya degradasi sumber daya alam tersebut. Upaya ini harus didukung oleh pemerintah untuk memberikan kesejahteraan mayarakat di darah pesisir di pulau-pulau kecil. Kata kunci : sumber daya alam, Over exploitation, degradasi, pengelolaan terpadu MODELLING OF COMMUNITY BASED INTEGRATED COASTAL AND SMALL ISLAND MANAGEMENT (CASE STUDY OF RAAS ISLAND SUMENEP DISTRICT MADURA Indonesia is a maritime nation consists of small islands. One of them is the Raas island of Madura. This island has abundant natural resources along its coastline however most of the population lives under the poverty line. Over exploitation of fisheries resources and economic crisis caused competition to obtain the remaining of natural resources resulting in the degradation of natural resources. Integrated coastal and small island management is expected to prevent the degradation. This effort should be supported by the government in order to provide prosperity for the coastal community.Key words : natural resources, over exploitation, degradation, integrated management

  19. IDENTIFIKASI SENYAWA EKSTRAK ETANOL DAUN MIMBA (Azadirachta indica A.Juss SEBAGAI ANTIBAKTERI SECARA KLT-BIOAUTOGRAFI TERHADAP BAKTERI Stahpylococcus aureus DAN Escherichia coli

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    Nurfijrin Ramadhani

    2017-03-01

    Full Text Available Rendahnya kesadaran masyarakat dan kurangnya sarana kesehatan membuat penyakit infeksi semakin meningkat. Pengobatan secara alami sekarang menjadi pilihan baru sebagai antibakteri, salah satunya adalah mimba. Penelitian sebelumnya menunjukkan bahwa daun mimba dapat menghambat pertumbuhan bakteri, akan tetapi belum diketahui senyawa apa yang berperan sebagai antibakteri tersebut. Penelitian ini bertujuan untuk mengetahui di dalam daun mimba senyawa yang berperan sebagai antibakteri. Penelitian dilakukan dengan metode KLT Bioautografi langsung, dimana hasil maserasi esktrak etanol daun mimba yang telah dielusi ditempelkan ke media yang telah ditanami bakteri Staphylococcus aureus dan Escherichia coli. Zona hambat yang terbentuk dilakukan identifikasi senyawa dengan menggunakan pereaksi semprot Dragendorf, FeCl3, Sitroborat, Lieberman Bouchardat, dan SbCl3. Hasil uji KLT-Bioautografi menunjukkan bahwa daun mimba dapat menghambat pertumbuhan bakteri yang ditandai dengan terbentuknya zona bening masing-masing dengan Rf 0,4 pada bakteri Staphylococcus aureus dan Escherichia coli. Senyawa yang berperan sebagai antibakteri terhadap bakteri Staphylococcus aureus dan Escherichia coli diduga adalah senyawa saponin dimana terbentuk warna ungu dengan pereaksi SbCl3.

  20. Perbandingan Efektivitas Daya Hambat Kotrimoksazol Generik dan Paten terhadap Pertumbuhan Bakteri Escherichia coli sebagai Penyebab Infeksi Saluran Kemih secara In Vitro

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    Puti Anggun Sari

    2015-01-01

    Full Text Available AbstrakInfeksi saluran kemih merupakan salah satu infeksi yang sering ditemukan setelah infeksi saluran napas. Penyebab terbanyak infeksi saluran kemih adalah Escherichia coli. Kotrimoksazol merupakan kombinasi dari dua obat yaitu trimetoprim dan sulfametoksazol serta salah satu contoh antibiotik yang merupakan first-line therapy untuk infeksi saluran kemih. Kotrimoksazol terbagi menjadi dua jenis obat yaitu obat generik dan paten. Akan tetapi, belakangan ini penggunaan obat generik mulai menurun di masyarakat dan masyarakat cenderung meragukan kualitasnya. Padahal masyarakat yang akan diuntungkan jika mengetahui mutu obat generik tidak kalah dengan obat paten. Tujuan dari penelitian ini adalah untuk membandingkan efektivitas daya hambat kotrimoksazol generik dan paten terhadap pertumbuhan bakteri Escherichia coli sebagai penyebab infeksi saluran kemih secara in vitro. Penelitian ini merupakan penelitian analitik eksperimental dengan desain cross-sectional study. Penelitian ini menggunakan 19 sampel isolat bakteri dari pasien infeksi saluran kemih yang disebabkan oleh Escherichia coli di RSUP Dr. M. Djamil yang ditentukan rumus minimal adequate sample size menggunakan metode difusi cakram dan dilihat perbandingan antara zona bebas kuman yang dibentuk oleh obat generik dan paten tersebut. Data yang diperoleh akan diolah secara statistik dengan uji hipotesis t-independent test. Hasil penelitian menunjukkan bahwa pada 17 sampel tidak didapatkan zona bebas kuman baik pada kotrimoksazol generik atau paten. Sedangkan pada 2 sampel lainnya didapatkan zona bebas kuman pada kedua obat kotrimoksazol generik dan paten. Setelah dilakukan analisis statistik menggunakan SPSS dengan uji t-independent test didapatkan bahwa tidak terdapat perbedaan bermakna antara sensitivitas bakteri Escherichia coli penyebab infeksi saluran kemih terhadap kotrimoksazol generik dan paten. Sedangkan resistensi yang terjadi pada 17 sampel lain diduga disebabkan penggunaan

  1. Strategi Pengelolaan Usaha Jasa Rumah Pemotongan Hewan Ruminansia Secara Berkelanjutan (MANAGEMENT STRATEGY FOR SUSTAINABLE RUMINANT-CATTLE SLAUGHTERHOUSE (RC-S SERVICES

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    Maya Dewi Dyah Maharani

    2017-04-01

    Full Text Available Uncontrolled cattle slaughtering may result in reduce water quantity and quality, number of cattle, and product of animal origin that does not fit the criteria of safety-healthy-whole-halal. The research objective was to analyze and measure important variables which might be required in developing a modelas well as to formulate strategic plans for managing sustainable abattoir services. Analysis methods used in this study were: Multidimensional Scaling (MDS or rap-slaughterhouse, Monte Carlo Analysis, and Analytical Hierarchy Process (AHP. Results of the analysis showed that the important variables were, i.e.: water availability and animal health status (ecological dimension; willingness to conduct hygienic and sanitation procedures at business scale level, service business orientation, availability of animal and slaughtering schedule management (economical dimension; workers safety and security (sociological dimension, noncompliance of the use of infrastructure by managers, workers and service users; lack off ulfillment of the requirements of the building frame (dimension regulations; and processing technology (technological dimension. The priority strategic analysis concluded that supply services of product of animal origin is eligible to be considered as components required in the food security program through the development and renovation program of effective slaughter houses. ABSTRAK Pemotongan hewan yang tidak terkendali mengakibatkan penurunan ketersediaan jumlah dan mutu air, hewan, dan pangan asal ternak yang tidak sesuai kriteria aman-sehat-utuh-halal (ASUH. Tujuan penelitian adalah menganalisis dan mengukur peubah-peubah penting yang diperlukan untuk menyusun model dan merancang rencana strategik pengelolaan usaha jasa rumah pemotongan hewan ruminansia secara berkelanjutan. Metode analisis yang digunakan adalah Multi Dimensional Scaling (MDS atau rap-slaughterhouse, Monte Carlo, dan Analytical Hierarchy Process. Hasil analisis

  2. PENGEMBANGAN WANA WISATA WATU SUMONG SEBAGAI KAWASAN EKOWISATA BERBASIS POHON AREN DAN PEMBERDAYAAN MASYARAKAT SECARA BERKELANJUTAN DI DESA PERON, LIMBANGAN, KENDAL

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    Eram Tunggul Pawenang

    2015-12-01

    Full Text Available Tujuan dari kegiatan ini adalah untuk memperdalam pengertian, penghayatan, dan pengalaman mahasiswa tentang cara berfikir dan bekerja interdisipliner pada lintas sektoral yaitu bidang ilmu Kesehatan Masyarakat, Hukum dan Akuntansi Manajemen, kegunaan hasil pendidikan dan penelitian bagi pembangunan pada umumnya dan pembangunan daerah pedesaan khususnya Desa Peron dalam membudidayakan pohon aren dalam fungsi konservasi dan pemberdayaan hasil pengolahan aren sebagai fungsi produksi, bagi perguruan tinggi dapat mengembangkan IPTEKS yang lebih bermanfaat dalam pengelolaan dan penyelesaian berbagai masalah pembangunan. Masalah utama yang ada di Desa Peron adalah petani aren dalam pemasaran hasil masih tergantung dengan tengkulak, kurangnya diversifikasi dari aren menjadi produk-produk yang lain, pengemasan hasil diversifikasi olahan aren kurang menarik konsumen, pemanfaatan ijuk, akar dan daun dari pohon aren yang tidak maksimal, potensi Wisata Watu Sumong yang belum dieksplorasi secara optimal serta kurangnya pengetahuan masyarakat tentang pengolahan limbah aren. Hasil dari kegiatan KKN PPM meliputi Program pengemasan gula aren dilaksanakan dengan 3 variasi bentuk pengemasan yaitu Gula aren cetak, Gula Semut dan Sirup Aren dengan label “Arenku” dan sedang dalam proses permintaan no PIRT. Program pemasaran gula aren telah terlaksana yaitu dengan memasarkan produk gula aren berupa gula semut aren, gula cetak dan sirup aren di beberapa tempat yaitu di KPRI Handayani, UNSEC UNNES, dan Sekatul. Kegiatan Pengenalan Watu Sumong telah dilaksanakan dan mendapat apresiasi positif dari Bupati Kendal dan Dinas Kebudayaan dan Pariwisata Kendal dan akan dikembangkan menjadi Desa Wisata. Pengenalan juga dilaksanakan pada saat Peron Expo dengan menampilkan Video dan Pemasangan papan sejarah Watu Sumong dan Denah Lokasi Wisata di Desa Peron. Pengembangan desa Wisata akan dilanjutkan oleh Kelompok sadar wisata “Wikir Sari”. Program

  3. Avaliação da escala de Epworth em pacientes com a Síndrome da apnéia e hipopnéia obstrutiva do sono Evaluation of Epworth Sleepiness Scale in patients with obstructive sleep apnea-hypopnea syndrome

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    Letícia Boari

    2004-12-01

    Full Text Available A síndrome da apnéia e hipopnéia obstrutiva do sono (SAHOS é, atualmente, considerada um problema de saúde pública por causar aumento da morbi-mortalidade cardiovascular e acidentes de trânsito. A polissonografia assistida é o padrão-ouro para o diagnóstico e acompanhamento destes pacientes. No entanto, por ser onerosa, demorada e de acesso restrito, outros métodos tem sido desenvolvidos. A escala de sonolência de Epworth (ESE é uma avaliação subjetiva, porém, rápida, sem custos e simples de ser aplicada. OBJETIVO: Avaliar a correlação entre a pontuação da ESE e o índice de apnéia e hipopnéia (IAH da polissonografia de pacientes com SAHOS. FORMA DE ESTUDO: Clínico retrospectivo. MATERIAL E MÉTODO: Revisão de prontuário de 66 pacientes com queixa de roncopatia que foram submetidos a procedimento cirúrgico (uvulopalatofaringoplastia com ou sem abordagem nasal. Avaliaram-se a pontuação da ESE e o IAH da polissonografia pré e pós-operatórios. RESULTADOS: 78,7% pacientes com grau normal de IAH tiveram pontuação de ESE menor do que 10 e 65% pacientes com grau severo de IAH tiveram pontuação maior do que 10. Não houve resultados estatisticamente significantes para os grupos moderado e leve. CONCLUSÃO: A escala de Epworth pode distinguir os graus normais e severos sem, no entanto, determinar os graus moderado e leve. Assim, pode ser utilizada para acompanhamento de pacientes com SAHOS sem, no entanto, substituir a polissonografia uma vez que não consegue avaliar todos os graus de severidade.Today obstructive sleep apnea–hypopnea syndrome (OSAHS is a public health issue, since it increases cardiovascular morbidity-mortality rate and the risk of car crashes. Overnight polysomnography is the gold standard for diagnosis and follow-up of affected patients. However, because the test is expensive, time-consuming and of difficult access, others methods have been proposed. Although the Epworth Sleepiness Scale (ESS is

  4. Studi Eksperimental Pengaruh Penambahan Disturbance Body Terhadap Karakteristik Aliran Yang Melintasi Sebuah Silinder Sirkular Yang Tersusun Secara Tandem Dalam Saluran Sempit ”Studi Kasus Untuk Disturbance Body Berulir Dan Polos Dengan Rasio Diameter D

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    Pratista Hariyanto

    2012-09-01

    Full Text Available Penelitian ini bertujuan untuk mempelajari aliran yang melintasi silinder sirkular yang tersusun tandem yang ditempatkan pada saluran sempit. Adapun penelitian ini juga berusaha untuk mereduksi gaya hambat yang terjadi dengan menggunakan sebuah disturbance body yang memiliki rasio yang d/D=0.1dengan kondisi permukaan polos dan berulir dengan rasio jarap gap L/D = 2.0. Penelitian ini dilakukan secara eksperimental dengan cara meletakkan silinder sirkular (D= 37.5mm dalam sebuah terowongan udara saluran sempit berpenampang bujur sangkar (h=125mm dengan bilangan Reynolds sebesar 1.16x102 (berdasarkan diameter hidrolis saluran dan kecepatan freestream. Tekanan diukur dengan pressure tap yang terpasang pada permukaan silinder sirkular dan pada test section terowongan angin (inlet dan outlet. Sedangkan profil kecepatan aliran didapatkan dengan menggunakan pitot static tube yang dipasang dibelakang silinder sirkular.

  5. Survey of public participation potential regarding the Muria NPP program

    International Nuclear Information System (INIS)

    Yarianto-SBS; Sri Hariani Syarif; Heni Susiati; Imam Hamzah; Fepriadi

    2003-01-01

    Socio-culture aspect is a part of site feasibility evaluation of Nuclear Power Plant (NPP)program. Indonesia is under going democratization, therefore the paradigm of development has also been changed where the people have freedom or liberty and they can express their opinion independently. The people are significant factor that involving in the decision making of regional development.Even the socio-culture, such as social riot can reject the site. Therefore socio-culture aspect should be considered in the NPP site evaluation. The first step of the study,mapping of public participation potential should be conducted by field survey. The method used in there search is quantitative approach with field survey guided by questioner without any treatment of object sampled. Qualitative approach was also conducted by in-depth interview technique to collect more detailed information. Information were collected from general public without any stratification in the 10 km radius from NPP site. Sampling method used was full random sampling technique. The results of survey show that the most of the people have significant potential for participating in the NPP Program. Conducive atmosphere should be maintained by social setting, therefore the present good momentum will not be lost. (author)

  6. Estudo comparativo da história clínica e da polissonografia na síndrome da apnéia/ hipopnéia obstrutiva do sono Comparative study between clinical history and polysomnogram in the obstructive sleep apnea/ hypopnea syndrome

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    Lys Maria Allenstein Gondim

    2007-12-01

    Full Text Available O reconhecimento dos distúrbios respiratórios do sono tem aumentado a cada ano. Manifestações, como o ronco, consideradas meros incômodos vêm adquirindo importância no que diz respeito à qualidade de vida e seu impacto social. OBJETIVO: Comparar a história clínica com os resultados da polissonografia (PSG, na Síndrome da Apnéia/Hipopnéia Obstrutiva do Sono (SAHOS, é o principal objetivo deste trabalho. MATERIAL E MÉTODOS: Foi realizado um estudo retrospectivo, com 125 pacientes, através da análise de questionários específicos, IMC e Escala de Epworth. RESULTADOS: Dentre os pacientes, 75 eram do sexo masculino e 50 do feminino. O principal sintoma foi a roncopatia. 46% apresentaram PSG normais, 30% SAHOS leve, 15% moderada e 9% severa, não se evidenciando correlação estatística entre a clínica e a PSG. Dentre as queixas, somente a insônia foi relevante, em análise univariada e em pacientes normais e com SAHOS leve (pRecognizing sleep-disordered breathing is on the rise every year. Manifestations, such as snoring, that were earlier considered mere inconvenients are now acquiring greater importance concerning life quality and social impact. AIM OF THE STUDY: To compare the clinical history to polysomnogram (PSG results in the Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS. MATERIALS AND METHODS: 125 patients were analyzed, in a retrospective study. Specific questionnaires, avaliations of Body Mass Index and Epworth Scale were carried out. RESULTS: Among the patients, 75 were males and 50 were females. The main symptom was snoring. 46% had normal PSG, 30% had light OSAHS, 15% moderate and 9% severe OSAHS and it was not observed a correlation between clinical data and PSG results. Concerning clinical symptoms, only insomnia has shown relevance when univariably analyzed in normal and light OSAHS patients (p<0,05 compared to patients with moderate and severe OSAHS, losing its importance when analyzed together with other

  7. Apnéia na sala de recuperação pós-anestésica: relato de caso Apnea en la sala de recuperación pós-anestésica: relato de caso Apnea in the postanesthetic recovery room: case report

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    Joel Massari Rezende

    2003-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A depressão respiratória é uma complicação que pode ocorrer no pós-operatório quando se utilizam opióides na anestesia. O objetivo deste relato é discutir um caso de apnéia em paciente que chegou consciente à sala de recuperação pós-anestésica (SRPA, após ter sido submetido à tireoidectomia sob anestesia geral com propofol, fentanil e isoflurano. RELATO DO CASO: Paciente do sexo feminino, 50 anos, 60 kg, estado físico ASA I, submetida à tireoidectomia sob anestesia geral induzida com propofol (140 mg, fentanil (350 µg, atracúrio (30 mg e mantida com isoflurano, duas doses subseqüentes em bolus de atracúrio (10 mg cada e ventilação controlada mecânica. No final da cirurgia, após antagonização do bloqueio neuromuscular, a paciente foi extubada, obedeceu aos comandos para respirar e colaborou na passagem à maca, sendo transportada para a SRPA, aonde chegou consciente. Minutos após, apresentou apnéia, cianose e inconsciência. Foi realizada ventilação manual com oxigênio a 100% seguida de injeção de naloxona (0,2 mg por via venosa, havendo retorno da ventilação espontânea e da consciência. CONCLUSÕES: Os cuidados ventilatórios no pós-operatório, durante o transporte, admissão à SRPA e permanência nessa unidade, devem ser contínuos em pacientes que receberam opióides, mesmo demonstrando estar conscientes ao deixarem a sala cirúrgica.JUSTIFICATIVA Y OBJETIVOS: La depresión respiratoria es una complicación que puede ocurrir en el pós-operatorio cuando se utilizan opioides en la anestesia. El objetivo de este relato es discutir un caso de apnea en paciente que llegó consciente a la sala de recuperación pós-anestésica (SRPA, después de haber sido sometido a tireoidectomia sobre anestesia general con propofol, fentanil e isoflurano. RELATO DE CASO: Paciente del sexo femenino, 50 años, 60 kg, estado físico ASA I, sometida a la tireoidectomia sobre anestesia general

  8. Prevalência de fatores de risco para a síndrome da apnéia obstrutiva do sono em motoristas de ônibus interestadual Prevalence of risk factors for obstructive sleep apnea syndrome in interstate bus drivers

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    Carlos Alberto de Assis Viegas

    2006-04-01

    Full Text Available OBJETIVO: Verificar a prevalência de fatores de risco para a síndrome da apnéia obstrutiva do sono em motoristas de ônibus interestadual. MÉTODOS: Foram avaliados 262 motoristas profissionais de ônibus interestadual, de empresa brasileira baseada no Distrito Federal, por questionário para avaliar distúrbios respiratórios do Sono, Escala de Sonolência de Epworth, testes de atenção concentrada e difusa, e medidas antropométricas. RESULTADOS: Encontravam-se com o peso acima do ideal 68% da amostra estudada, dos quais 34% apresentaram circunferência do pescoço = 42 cm. Durante o trabalho os motoristas referiram uso de tabaco (27%, refrigerantes à base de cola (55%, álcool (65% e café (88%, e 28% dos motoristas apresentaram mais de dez pontos na Escala de Sonolência de Epworth. Houve ainda 36% de roncadores, 5% referiram paradas respiratórias durante o sono, 12% apresentaram sensação de sufocamento, 29% sono agitado e 48% referiram sentir sono ao dirigir. Já se envolveram em acidentes de trânsito 42% dos motoristas e em 7,6% dos casos o acidente foi devido a sonolência excessiva. Aqueles com mais de dez pontos na Escala de Sonolência de Epworth apresentaram nível de atenção concentrada comprometido e quanto maior a circunferência do pescoço e a hipersonolência, menor a atenção difusa. CONCLUSÃO: No grupo de motoristas estudados, há uso alarmante de substâncias estimulantes e alta prevalência de hipersonolência diurna, que leva a diminuição da atenção.OBJECTIVE: To determine the prevalence of risk factors for obstructive sleep apnea syndrome in interstate bus drivers. METHODS: This study involved 262 professional interstate bus drivers employed by a Brazilian company headquartered in the Federal District. The drivers were evaluated using a questionnaire designed to assess respiratory sleep disorders, the Epworth Sleepiness Scale, test of sustained attention, test of divided attention and anthropometric

  9. ANALISIS POLA INTERAKSI SERANGGA-GLMA PADA EKOSISTEM SAWAH SURJAN DAN LEMBARAN YANG DIKELOLA SECARA ORGANIK DAN KONVENSIONAL (Analysis of Insect-Weed Interaction Pattern in Surjan and Lembaran Rice Farm Ecosystems under Organic and Conventional

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    Tien Aminatun

    2012-11-01

    Full Text Available ABSTRAK Penelitian ini bertujuan untuk menganalisis struktur food web dalam pola interaksi serangga-gulma pada ekosistem sawah surjan dan lembaran yang dikelola secara organik dan konvensional.        Penelitian dilakukan pada enam petak sawah surjan dan enam petak sawah lembaran di daerah Kulon Progo dalam dua musim tanam pada bulan Desember 2009 sampai Juli 2010.  Baik sawah surjan maupun sawah lembaran, masing-masing dibedakan dalam dua pengelolaan, yaitu pengelolaan organik dan konvensional, dengan ulangan masing-masing tiga petak.  Lima plot ukuran 1x1 m ditempatkan pada masing-masing petak yang tidak diubah posisinya sampai berakhir satu musim tanam. Inti dari penelitian lapangan ini adalah menghitung jenis dan kelimpahan gulma setiap tiga minggu sekali untuk setiap petak, demikian juga untuk jenis dan kelimpahan dari serangga herbivora untuk setiap jenis tanaman/gulma pada setiap plot. Analisis data dilakukan dengan program Bipartite in R statistics 2.12.0, dan dilakukan uji pengaruh tipe sawah dan cara pengelolaan lahan terhadap struktur dan network level (jumlah jenis trofik atas, jumlah jenis trofik bawah, keterhubungan, diversitas Shannon, dan kemerataan interaksi dengan menggunakan General Linear Model (GLM dalam program SPSS 17.0. Hasil penelitian sawah surjan yang dikelola secara organik mempunyai pola interaksi serangga-gulma yang lebih kompleks dengan lebih banyak link interaksi, jumlah jenis trofik atas dan bawah, indeks diversitas Shannon, dan kemerataan interaksi yang lebih tinggi, serta keterhubungan (connectance yang lebih rendah.  ABSRACT The aims of this research was to analyse food web structure of insect-weed interaction in surjan and lembaran rice field ecosystems under organic and conventional managements. We observed six rice fields of local farms called “surjan” rice fields, and six rice fields of “lembaran” farms in Kulon Progo District, central Java, in two planting seasons in December 2009 until

  10. DAMPAK PACARAN SECARA HOLISTIK TERHADAP REMAJA

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    Hikmah Hikmah

    2014-04-01

    Full Text Available Thisstudy aims at knowing the impact of going to the physical, psychological, social, spiritual (holistic inclass X and XI in MAN 1 Wates in 2013. The reason this research because the results obtained from in-depth interviews in 4 students MAN 1 Wates lackof knowledge about the courtship activities and impactso there are irregularities in the reproductive organs as well as the impact of physical,psychological,social and spiritual students. The method used by the Qualitative Quantitative Descriptivesampling technique used "Simple Random Sampling". Quantitative respondents in this study werestudents of class X and XI as many as 181 people, while respondents in-depth qualitative interviews withas many as 4 people. The results showed that there is going to impact as much as 75.2 % physical, 74%psychological, social as much as 73.5 %, 76.7 % and spiritual as much as 52.5 % holistic impact. ForMAN 1 Wates is expected to provide the facilities and infrastructure to provide information onreproductive health knowledge and prevention of courtship holistic impact both on the parents and to thestudents directly through counseling and peer group .

  11. BELAJAR BAHASA SECARA HOLISTIK: APAKAH PANDANGAN MURID ?

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    Zulkifli Osman

    2013-10-01

      Learning Language by Holistic Approach: What Atudent’s View”. A variety of teaching approaches such as structural approach, code-cognitive, communicative was implemented in the classroom. These approaches have their own specific strength and weakness. The cod-cognitive approach emphasizes on the ability of the students to mastering the language competence. The communicative approach likewise to enhance on the communication process only. The purpose of this study is to introduce the implementation of the holistic approach in teaching of the Malay Language to ensure pupils are able to learn the language as a whole or holistic. In order to obtain the student’s views on the implementation of this approach, questionnaire and semi-structured interview was implemented. Document analysis also used in order to support the data. One hundred and twenty five students are involved in this study whose consist of three classes of Form Four (SMA. Questionnaires and interviews were administered to the students after teaching modules run. Results showed that the language process by using the holistic approach is more attractive. This approach is able to increase the student’s motivation and language skills. Implications of the study are also discussed Keywords: Learning language, language learning, holistic approach,                   language teaching modules

  12. Perawatan Kasus Diastema Multipel Secara Multidisiplin

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    Fadli Jazaldi

    2012-10-01

    Full Text Available Diastemas are spaces or gaps between two or more consecutive teeth. They can occur anywhere in the upper or lower dental arches. Diastemas can occur in mixed dentition and closes spontaneously when the canines erupt, but in certain circumstances, diastema will persist until period of permanent teeth. This etiologic factor has to identify because it will influenc effectivenees of closing the multiple diastemas. The multiple diastemas that happened at the anterior upper and lower which caused by deficient tooth structure and missing of some teeth (agenesis, accompanied of central diastema which influenced by anterior labialis frenulum, should treated comprehensively. Treatment of this case entangle ortodontic, periodontic, conservative dentistry, and prostodontic. Reposition of abnormal frenulum attachment (frenectomy, arrangement of occlusion and teeth interdigitation, getting continuity of dental arch through achieving good approximal teeth contact by crown reshaping andreplaced of missing tooth element with prothesis, and then making of retainer to maintain stability of treatment result are serial of treatments for the case. By cooperation of multidicipline proffesionals, the final result is to obtain the optimal esthetics, functional, and stability result of  treatment, will achived.DOI: 10.14693/jdi.v15i3.29

  13. Pemetaan Risiko Tsunami terhadap Bangunan secara Kuantitatif

    Directory of Open Access Journals (Sweden)

    Totok Wahyu Wibowo

    2017-12-01

    Full Text Available ABSTRAK Tsunami merupakan bencana alam yang sebagian besar kejadiannya dipicu oleh gempabumi dasar laut. Dampak kerugian tsunami terhadap lingkungan pesisir antara lain rusaknya properti, struktur bangunan, infrastruktur dan dapat mengakibatkan gangguan ekonomi. Bencana tsunami memiliki keunikan dibandingkan bencana lainnya, karena memiliki kemungkinan sangat kecil tetapi dengan ancaman yang tinggi. Paradigma Pengurangan Risiko Bencana (PRB yang berkembang dalam beberapa tahun terakhir yang menekankan bahwa risiko merupakan hal utama dalam penentuan strategi terhadap bencana. Kelurahan Ploso, merupakan salah satu lokasi di Kabupaten Pacitan yang berpotensi terkena bencana tsunami. Pemetaan risiko bangunan dilakukan dengan metode kuantitatif, yang mana disusun atas peta kerentanan dan peta harga bangunan. Papathoma Tsunami Vulnerability 3 (PTVA-3 diadopsi untuk pemetaan kerentanan. Data harga bangunan diperoleh dari kombinasi kerja lapangan dan analisis Sistem Informasi Geografis (SIG. Hasil pemetaan risiko menunjukkan bahwa Lingkungan Barehan memiliki risiko kerugian paling tinggi diantara semua lingkungan di Kelurahan Ploso. Hasil ini dapat dijadikan sebagai acuan untuk penentuan strategi pengurangan risiko bencana di Kelurahan Ploso. ABSTRACT Tsunami is a natural disaster whose occurrences are mostly triggered by submarine earthquakes. The impact of tsunami on coastal environment includes damages to properties, building structures, and infrastructures as well as economic disruptions. Compared to other disasters, tsunamis are deemed unique because they have a very small occurrence probability but with a very high threat. The paradigm of Disaster Risk Reduction (DRR that has developed in the last few years stresses risk as the primary factor to determine disaster strategies. Ploso Sub-district, an area in Pacitan Regency, is potentially affected by tsunamis. The risk mapping of the buildings in this sub-district was created using a quantitative method based on maps of vulnerability and building’s cost. This research used Papathoma Tsunami Vulnerability 3 (PTVA-3 for vulnerability mapping. The cost of the buildings was obtained from a combination of fieldwork and Geographic Information System (GIS. The results of risk mapping showed that the Barehan Environment had the highest risk of loss among the other environments in Ploso Sub-district. These findings, thereby, can be used as a reference for determining DRR strategy in Ploso Sub-district.

  14. Pembelajaran Interdisipliner: Upaya Mengapresiasi Sastra Secara Holistik

    Directory of Open Access Journals (Sweden)

    Daru Kabeka Janarto

    2010-10-01

    Full Text Available The research is regarding 4 class cycle about interdisciplinary teaching technique of literature teaching in BINUS International School Simprug, Jakarta. The interdisplinary teaching is done in grade 10 in 3 subjects of Indonesian Language and Literature, Computer (IT, and Visual Arts. The teaching topic is Ma Yan, a novel about Muslim teenager who struggles for education in Zhang Jiashu, a remote village in China. This teaching climax is talk show with the writer of Ma Yan and its publisher followed with visual arts show from the students. The observation result shows that talent and involvement of students are high through the learning materials, proved by assignments done in time and their antusiasm towards their projects and assignments.  

  15. PERANCANGAN MESIN PENYAYAT BAMBU SECARA ERGONOMIS

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    Agung Kristanto

    2012-12-01

    Full Text Available Jamboel Kipas adalah UKM yang memproduksi souvenir kipas dengan sistem pesanan make to order. Seiring perkembangan waktu, Jamboel Kipas tidak dapat memenuhi pesanan karena keterbatasan kapasitas produksi souvenir kipas. Hal ini disebabkan karena waktu proses yang lama terjadi pada bagian penyayatan bambu, yaitu sebesar 22 detik/iratan. Penelitian ini ditujukan untuk meningkatkan produktivitas penyayatan bambu serta memperbaiki posisi operator saat bekerja, dengan perancangan mesin penyayat bambu berdasar anthropometri ukuran tubuh operator, keluhan selama bekerja, dan waktu proses penyayatan bambu. Hasil penelitian setelah perancangan menunjukan posisi operator saat bekerja cukup ergonomis karena ukuran tempat kerja disesuaikan dengan dimensi antropometri operator. Waktu baku pada kondisi sebelum perancangan sebesar 21,16 detik/iratan dan output standar sebesar 170,09 iratan/jam. Sedangkan setelah perancangan sebesar 4,42 detik/iratan dan output standarnya sebesar 815,22 iratan/jam dengan peningkatan output standar 479,46%, terjadi penurunan waktu baku sebesar 378,73%. Sementara itu nilai break event point terjadi ketika UKM Jamboel Kipas sudah memproduksi 12927 kipas.

  16. PERANCANGAN MESIN PENYAYAT BAMBU SECARA ERGONOMIS

    Directory of Open Access Journals (Sweden)

    Agung Kristanto

    2012-12-01

    Full Text Available Jamboel Kipas adalah UKM yang memproduksi souvenir kipas dengan sistem pesanan make to order. Seiring perkembangan waktu, Jamboel Kipas tidak dapat memenuhi pesanan karena keterbatasan kapasitas produksi souvenir kipas. Hal ini disebabkan karena waktu proses yang lama terjadi pada bagian penyayatan bambu, yaitu sebesar 22 detik/iratan. Penelitian ini ditujukan untuk meningkatkan produktivitas penyayatan bambu serta memperbaiki posisi operator saat bekerja, dengan perancangan mesin penyayat bambu berdasar anthropometri ukuran tubuh operator, keluhan selama bekerja, dan waktu proses penyayatan bambu. Hasil penelitian setelah perancangan menunjukan posisi operator saat bekerja cukup ergonomis karena ukuran tempat kerja disesuaikan dengan dimensi antropometri operator. Waktu baku pada kondisi sebelum perancangan sebesar 21,16 detik/iratan dan output standar sebesar 170,09 iratan/jam. Sedangkan setelah perancangan sebesar 4,42 detik/iratan dan output standarnya sebesar 815,22 iratan/jam dengan peningkatan output standar 479,46%, terjadi penurunan waktu baku sebesar 378,73%. Sementara itu nilai break event point terjadi ketika UKM Jamboel Kipas sudah memproduksi 12927  kipas.

  17. Pengolahan Limbah Cair Rumah Sakit secara Sonochemical

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    Laila Kusuma

    2017-06-01

    Full Text Available Hospital as a service provider has an important role in human life, especially for people who are experiencing physical and mental disorders. Various types of diseases and therapies performed in hospitals has made it as one of the producers of hazardous and infectious waste that requires special handling and processing so as not to pollute the water, soil, and air environment. Hospital wastewater treatment was conducted to determine the ability of sonochemical method to reduce level of Chemical Oxygen Demand (COD and determine the optimum conditions of the parameters used by the design of Response Surface Methodology Box-Behnken. The parameters that affected this process was the concentration of hydrogen peroxide (H2O2, pH, and reaction time. The Waste used was taken from the waste water treatment plant in Zainoel Abidin General Hospital in Banda Aceh with COD value 260.65 ppm. The optimum conditions of this treatment process occured at pH 2, H2O2 concentration 500 ppm, and reaction time 119.98 minutes with reduction of COD was 81.88%.ABSTRAKRumah sakit sebagai penyedia layanan jasa memegang peranan cukup penting dalam kehidupan manusia, terutama bagi orang-orang yang sedang mengalami gangguan fisik dan mental. Berbagai jenis penyakit dan terapi yang dilakukan di rumah sakit telah menjadikannya sebagai salah satu penghasil limbah berbahaya dan infeksius yang memerlukan penanganan dan pengolahan khusus agar tidak mencemari lingkungan yaitu air, tanah dan udara. Pengolahan limbah cair rumah sakit dilakukan untuk mengetahui kemampuan metode sonochemical dalam menurunkan kadar Chemical Oxygen Demand (COD dan menentukan kondisi optimum dari parameter yang digunakan berdasarkan disain Response Surface Methodology Box-Behnken. Parameter yang mempengaruhi proses ini adalah konsentrasi hidrogen peroksida (H2O2, pH, dan waktu reaksi. Limbah yang digunakan diambil dari instalasi pengolahan air limbah di Rumah Sakit Umum Zainoel Abidin Kota Banda Aceh dengan nilai COD sebesar 260,65 ppm. Kondisi optimum dari proses pengolahan terjadi pada pH 2, konsentrasi H2O2 500 ppm, dan waktu reaksi 119,98 menit dengan penurunan COD sebesar 81,88 %

  18. Keterampilan Mendengarkan Secara Aktif dalam Komunikasi Interpersonal

    Directory of Open Access Journals (Sweden)

    Nikodemus Thomas Martoredjo

    2014-04-01

    Full Text Available Interpersonal communication is transactional and two-way direction. Therefore active listening skills play a key role in interpersonal communication. These active listening skills can have a positive impact on communication and at the same time creating a better relationship. So it is very useful to improve the skills of active listening. This paper intends to reveal the important role of active listening skills in interpersonal communication, identifying the challenges that exist within it both internally and externally as well as indicate the action that needs to be developed to improve these skills. 

  19. KEANEKARAGAMAN JENIS TUMBUHAN YANG BERGUNA SECARA LOKAL DI DESA BATU AMPAR, DI DEKAT KAWASAN HUTAN LINDUNG BUKIT RAJA MANDARA, KABUPATEN BENGKULU SELATAN (The Diversity of Locally Useful Plants in Batu Ampar Village Near Bukit Raja Mandara Protected

    Directory of Open Access Journals (Sweden)

    Wiryono Wiryono

    2013-07-01

    Full Text Available ABSTRAK Keanekaragaman jenis tumbuhan memiliki banyak fungsi bagi masyarakat, terutama adalah mereka yang tinggal di daerah pedesaan. Masing-masing masyarakat tradisional di Indonesia memiliki pengetahuan khusus tentang tumbuhan yang terdapat di lingkungan mereka dan pemanfaatanya. Memiliki banyak jenis tumbuhan dan suku bangsa, Indonesia kaya akan keanekaragaman biologi dan budaya. Namun, pertanian modern dan globalisasi cenderung menurunkan keanekaragaman biologi dan budaya tersebut. Oleh karena itu, pelestarian pengetahuan dan pemanfaatan tradisional sangat penting untuk dilakukan. Penelitian ini bertujuan untuk mendokumentasikan keanekaragaman jenis tumbuhan yang digunakan oleh penduduk desa Batu Ampar, di Kecamatan Kedurang, Kabupaten Bengkulu Selatan. Hasil penelitian menunjukkan bahwa penduduk desa tersebut memanfaatkan 83 jenis tanaman dalam 8 kategori, yaitu bahan makanan sebanyak 35 jenis, bahan obat-obatan 30 jenis, bahan bangunan 16 jenis, kayu bakar 9 jenis, pagar dan pagar hidup 9 jenis, kerajinan tangan 9 jenis, pewarna 1 jenis dan racun 1 jenis. Lima puluh lima jenis tumbuhan diambil dari lahan pribadi dan 28 jenis dari hutan. Secara ekonomis, 54 jenis tumbuhan dimanfaatkan untuk keperluan sendiri, sedangkan 29 jenis tumbuhan selain dimanfaatkan sendiri juga dijual. ABSTRACT The diversity of plant species serves many purposes for community, especially those living in rural areas. Each traditional community inIndonesiamay have specific knowledge and use of plants found in their environment.  Having many plant species and tribes,Indonesiais rich in biological and cultural diversity. Modern agriculture and globalization, however, tends to reduce both diversities. It is, therefore, essential that traditional knowledge and uses of biological diversity be preserved. This study was aimed to document the diversity of plants used by villagers of Batu Ampar,KedurangSubdistrict, South Bengkulu District. Results showed that villagers used

  20. Pemodelan Matematik Kinerja Pengering Surya Efek Rumah Kaca (ERK-Hibrid Menggunakan Rak Berputar secara Vertikal (Mathematical Modeling Performance of Greenhouse Effect (GHE-Hybrid Solar Dryer with a Vertical Rotating Rack

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    Sigit Triwahyudi

    2016-12-01

    ini menyajikan uji unjuk kerja dan pemodelan matematik pengering energi surya (ERK-Hibrid  menggunakan  rak berputar secara vertikal. Pengering terdiri dari bangunan rumah kaca berukuran (1100 × 860 × 1300 mm dengan delapan buah rak dan sistim pemanas tambahan yang terdiri dari kolektor plat datar (1,04 m2, tangki penyimpan air panas (197 liter dan penukar panas. Untuk mengetahuikinerja pengering energi surya, dilakukan lima kali percobaan variasi kecepatan putar rak (1, 4, 7, 10 rpm dan tanpa pemutaran rak. Bahan yang dipergunakan pada pengujian adalah kapulaga lokal (Amomum cardamomum Wild. Masing-masing percobaan seberat 9 sampai dengan 10 kg. Rata-rata suhu air tangki penyimpan panas bervariasi dari 50,0 sampai dengan 55,0 °C suhu ruang pengering antara 38,9 sampai dengan 45,9 °C, sedangkan kelembaban relatif (RH ruang pengering berkisar antara 32,1 sampai dengan 47,4 %. Perlakuan pemutaran rak berpengaruh terhadap keseragaman suhu bahan maupun kadar air pada masing rak pengering. Pada perlakuan pemutaran 1 rpm (percobaan II, didapatkan kondisi terbaik (suhu bahan maupun kadar air yang paling seragam. Dengan kecepatan putar rak yang semakin meningkat menyebabkan nilai ragam suhu bahan maupun kadar air semakin meningkat. Untuk melakukan simulasi unjuk kerja dilakukan pemodelan matematik berdasarkan pindah panas dan massa serta pendekatan pengeringan lapisan tipis. Persamaan diselesaikan secara numerik menggunakan finite difference Euler dengan bantuan bahasa pemrograman Visual Basic Aplication (VBA Excell. Validasi dilakukan dengan membandingkan antara perhitungan hasil pemodelan (data prediksi dengan data hasil pengukuran (data observasi. Kriteria kevalidan ditentukan dengan melihat nilai koefisien determinasi (R2, nilai RMSD maupun nilai MAPD. Pemodelan  matematik yang telah dibangun dapat menggambarkan dengan tepat perubahan suhu air tangki penyimpan panas, suhu ruang pengering, suhu bahan maupun penurunan kadar air. Kata kunci: Pengering surya efek rumah

  1. Investigation on seismic characteristic in Muria Peninsula to asses the NPP seismic design

    International Nuclear Information System (INIS)

    Kusnowo, A.

    1997-01-01

    A feasibility study on first nuclear power plant was conducted during 4,5 years started on 22 November 1991. This study consists of two parts. First, the non site study, Second part is the site and environmental study. The scope of non site studies are economic financing, technical and safety aspect as well as fuel cycle and waste management aspect. The site and environmental studied consist of site conditions and qualification, seismological, environmental condition as well as social economic and cultural impact. In the first step of site study (step 1), the result come up to the three candidates named Ujung Lemahabang, Ujung Watu and Ujung Grenggengan. Further study on geology, topography, oceanography, geophysics, hydrology, seismology, vulcanology, man induced event, etc was done on those three candidates (named as step 2). The results come up with Ujung Lemahabang as the best candidates. It is important to know basic, characteristic of seismicity of nuclear power plant sitting region for seismic hazard assessment this was done as step 3. This paper describe the results of step 3. (J.P.N.)

  2. Investigation on seismic characteristic in Muria Peninsula to asses the NPP seismic design

    Energy Technology Data Exchange (ETDEWEB)

    Kusnowo, A [National Atomic Energy Agency, Jakarta (Indonesia)

    1997-03-01

    A feasibility study on first nuclear power plant was conducted during 4,5 years started on 22 November 1991. This study consists of two parts. First, the non site study, Second part is the site and environmental study. The scope of non site studies are economic financing, technical and safety aspect as well as fuel cycle and waste management aspect. The site and environmental studied consist of site conditions and qualification, seismological, environmental condition as well as social economic and cultural impact. In the first step of site study (step 1), the result come up to the three candidates named Ujung Lemahabang, Ujung Watu and Ujung Grenggengan. Further study on geology, topography, oceanography, geophysics, hydrology, seismology, vulcanology, man induced event, etc was done on those three candidates (named as step 2). The results come up with Ujung Lemahabang as the best candidates. It is important to know basic, characteristic of seismicity of nuclear power plant sitting region for seismic hazard assessment this was done as step 3. This paper describe the results of step 3. (J.P.N.)

  3. Measurement Testing of Radon Gas for Fault Activity Detection in Rahtawu Muria, Pati

    International Nuclear Information System (INIS)

    Suntoko, Hadi; Hamzah, Imam

    2004-01-01

    The radon surface can be used to investigates not only for environment but also to be develop in an earth application. The investigation is carried out at the Rahtawu fault, that includes, to the Pati regency which is located 40 km South of ULA. The objective of study to measure the radon released from the fracture zone activities. RDA equipment is being used to measure the radon gas released. The result shown that the high value of radon is 311 cpm with the background of 18 cpm, whereas the low value falls at 0 cpm. The tattoo value are influenced by the soil condition, tattoo time, hardness, weather, soil/stone porosity and fault possession. (author)

  4. Geological study of Ujungwatu area as support for NPP planning in Muria Central Java

    International Nuclear Information System (INIS)

    Srijono

    1995-01-01

    In accordance with growth of life in Java, the need for electricity is also growing accordingly. Efforts to provide electricity such as planning to build nuclear power plant (NPP) has been in the debate for a while. There are many factors to be considered in this planning, such as its environmental condition. Geological factor is one of the important one to be considered. Surface geological conditions around NPP area at Ujungwatu needed include stratigraphy, geological structure, geomorphology, and environmental geology. Geology in Ujungwatu at radius 5 km is quite interesting. This area is part of Genuk volcano group which is laid at south and Ujungwatu coast at north. Genuk mountain group is divided into mountain slope, mountain back, and mountain skeleton. Coastal area is composed of coast sand. Sand up to broken rock was present along river gullies. Others were volcanic rocks which was composed of lapili tuff, trachite, pyroxene andesite, tuff breccia, tephrite-andesitic tuff breccia, and basaltic tuff breccia. Volcanic structure is well reflected by morphological feature as lineaments and half circular form in mount Genuk. This structure was predominantly in NW-SE direction, and less dominant in NE-SW direction. Ujungwatu, from environmental view, is deserved to be developed because of its underground potency. Iron sand, fluvial tuff, kaolin, mud, riverstone, volcanic rock, tuff and marble were easily found underground. Those could be benefited to the people in the area so that it could change socio-economical condition of the people which in turn electricity is becoming a necessity. Last but not least, Portuguese fort as potential touristic object is also situated at Kartini beach near Ujungwatu. (author). 15 refs, 3 tabs, 5 figs

  5. Latihan Keterampilan Intelektual dan Kemampuan Pemecahan Masalah Secara Kreatif

    Directory of Open Access Journals (Sweden)

    Deetje Josephine Solang

    2016-02-01

    Full Text Available The study tries to investigate the utilization of intellectual creative skills within the framework of the triarchic theory of intelligence in reading activities. The subject in which the theory was applied was Bahasa Indonesia (Indonesian. This experimental study involved randomly selected seventh graders of Junior High School. There were three hypotheses to test in the study. First, the order of the three types of intellectual skills suggested in the triarchic theory of intelligence presented during training as well as during instruction has effects on students' performance in attempting creative solution to problems derived from reading texts in the subject of Bahasa Indonesia. Multiple comparisons were employed to test this hypothesis. Second, there is a significant difference in creative problem solving performances between the experimental and the control groups. Analysis of variance was carried out to test this hypothesis. Third, scholastic aptitude has a role in predicting the creative problem solving performance. ANACOVA was employed to test this hypothesis. The results show that the students show the best performance when they are trained using the thinking order of practice-synthesis-analysis.

  6. Aplikasi Android Untuk Berbagai Jenis Toko Secara Online

    OpenAIRE

    Gunawan, Chandra Ari; Kasih, Julianti

    2016-01-01

    E-Commerce as an alternative mean of transaction along with the USAge of smartphone as a tool to perform e-commerce transaction is gaining ground. This development could be seen from the emergence of numerous mobile payment applications.The USAge of mobile devices to pay for goods, services, bills, or money transfer.Stores as a location for transaction are currently in a fierce completion to gain customers, on the other hand, there are issues for the customers, the customers often do not have...

  7. UPAYA PENGAKARAN Echinacea purpurea L DENGAN AUKSIN SECARA KULTUR JARINGAN

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    Heru Sudrajat

    2013-03-01

    Full Text Available Recently, to meet the needs of botanicals medicinal plants the cultivation directed, require good quality and uniform seeds on form and time.    Tissue culture research to from root of Echinacea purpurea L by the provision of IBA and NAA will be conducted.This recearched aimed to develop an and cultivate qualified Echinacea purpurea L as the raw material for drug foemulation. Tissue culture techniques has  more advantage because it is not affected by the climate, relatively fast production, free contamination of microbial and do not require large tracts of land. The research was carried out considering the need to be developed and cultivated plant Echinacea purpurea L qualified as raw material for the drug tissue culture techniques has advantages because it is not affected by the climate with relatively fast production time, free of microbial contamination and do not require large tracts of land. Shoots multipication done on MS medium using growth regulators GA3with concentration of 3 mg / l. Research foor rof induction on Echinacea purpurea L shoot made by adding growth regulators of IBA and NAA with concentrations with 0, 2, 4 and 6 mg / l respectively. The 2 months incubation periods produced tehe best root induction on the additon of IBA 4 mg / l. It producted 16 roots with a length of 4 cm and relatively lagre in size.Keywords: Echinacea purpurea L., tissue culture, IBA, NAA, plant growth regulators

  8. PELATIHAN PEMECAHAN MASALAH SECARA KREATIF UNTUK MENINGKATKAN KINERJA WIRANIAGA

    Directory of Open Access Journals (Sweden)

    Listya Istiningtyas

    2016-05-01

    Full Text Available Sales people often experience obstacle in marketing, it’s because they disable to face troubles that appear. Salespeople need creative problem solving ability to do their job. The main purpose of this research is to examine the effectiveness of creative problem solving training to increase job performance. This research use quasi experimental approach with the untreated control group design with pretest and posttest plan. Creative problem solving training is given to the experimental group and the control group did not receive this training. The subjects are salespeople of dealer motorcycle who face consumer directly. The subject is divided into experimental group (18 subject, middle area and control group (18 subject, south area. Job performance form is made by researcher and company party to appraise job performance. The result of the data were analyzed by mixed anova with statistic programe SPSS 15.0 for Windows. The result showed that creative problem solving training can significant increase job performance in experimental group (F = 13,387; p < 0,01. The experimental group showed higher job performance than the control group. This research goes to show that Creative problem solving training contributes 28,3 % in increasing the level of job performance.

  9. Pengendalian Penyakit Busuk Pangkal Batang Kelapa Sawit secara Kultur Teknis

    Directory of Open Access Journals (Sweden)

    Hari Priwiratama

    2014-08-01

    Full Text Available Effort to manage basal stem rot disease (BSR caused by Ganoderma boninense could be conducted through several cultural practice approaches. Four series of field experiments was conducted to observe the effectiveness of cultural practice methods for controlling the epidemic of basal stem rot due to G. boninense. Sanitation trial consisted of three treatments i.e root sanitation with big hole planting system, big hole without root sanitation, and standard replanting system as comparison. Hole in hole and standard planting system were compared in the hole in hole trial. Digging and mounding trial was conducted in four treatments, i.e. digging and mounding with teer and Trichoderma, digging and mounding with Trichoderma, mounding with Trichoderma, and infected palm without any treatment as comparison. Meanwhile, a 4 m × 4 m trench was used in the isolation trench trial. Annual observation was conducted to determine the disease incidence of BSR in each trial. Results showed that all methods could prevent palms from G. boninense infection in the early stage of oil palm development. Proper root sanitation delayed G. boninense infection until 2 years after treatment (YAT, hole in hole planting system was able to suppress disease incidence up to 7 YAT, digging and mounding was useful to prolong the life of the infected palms up to 3 YAT, meanwhile the use of isolation trench was demonstrated to prevent G. boninense infection to neighboring palms up to 2 YAT.

  10. Time Management: Menggunakan Waktu Secara Efektif dan Efisien

    Directory of Open Access Journals (Sweden)

    Antonius Atosökhi Gea

    2014-10-01

    Full Text Available Living in the midst of a changing business environment, which many people are burdened with more than one responsibilities, especially in a company with very high business activity and also in highly competitive industry, is imperative for the leaders of the company to be able to manage their time well in order to survive and be able to move in a sustainable manner. The concept of time management began during the industrial revolution and became a modern idea about doing things effectively and efficiently. Time management is one of the basic skills needed to be successful in life. The findings of various surveys indicated that time management enabled organizations or companies learn to survive in the face of competition and achieve a lot of success in business. 

  11. TEKNOLOGI PEMELIHARAAN LARVA KERAPU SUNU (Plectropomus leopardus SECARA MASSAL

    Directory of Open Access Journals (Sweden)

    Titiek Aslianti

    2016-12-01

    Seed production technology of leopard coral trout, Plectropomus leopardus by improving hatchery management had been conducted in order to increase survival rate and to produce seed continuity. The initial feeding can successfully support in larval rearing. Feed organism as rotifer, trochophore gonad, egg yolk emulsion, and artificial feed emulsion, had been used as an initial feed. The twelve of concrete tanks with 6 m3 capacity were stocked with coral trout eggs at density 100,000—150,000 eggs/tank. Artemia nauplii, artificial feed, and mysid as feed, start on larvae D20 up to juvenile stage (D45. Growth rate and survival rate were observed and calculated when the experiment was terminated. The data was analyzed by descriptive. Nutrition value of food was analyzed by proximate and fatty acid composition. The others parameters such as deformity and water quality were observed. The result showed that artificial feed emulsion and egg yolk emulsion as an initial feeding can be improve the growth rate and increase survival rate of larvae. The range of total length, body weight and survival rate of the seed i.e. 1.95—2.85 cm; 0.64—0.73 g, and 0.25%— 3.97% with the daily growth rate 3,9%—4,22%, respectively. No back bone deformity in the seed, that is 21—23 segments with interspaces of segments 0.030—0.036 mm.

  12. Kajian Peran Waduk Sebagai Pengendali Kualitas Air Secara Alami

    Directory of Open Access Journals (Sweden)

    Agung B. Supangat

    2016-08-01

    Full Text Available In Indonesia it was identified that there were much of polluted stream flow which cause improper consumed water. One of the rivers which has low of water qualities is Citarum River, West Java. However, along the Citarum river, there were built three reservoir dams (Saguling, Cirata and Jatiluhur that can control the condition of river water regime. Research was conducted in Citarum watershed to determine the role of those reservoirs on water quality control. Seven stations along the river were selected as observation posts of water samples. Based on the observation results it was indicated that water pollutants within Citarum river was very high. However, those pollutants could be purified or reduced by those reservoirs, hence water discharge from the reservoirs has better quality. In the future, deposition of those pollutants within the dam may has negative environment impact. Therefore, to sustain that function of the dam, comprehensive efforts on reducing pollutants from the catchment area is urgently required.

  13. UNJUK KERJA PENGOLAHAN LIMBAH CAIR TAHU SECARA BIOLOGI

    OpenAIRE

    Indriyati, Indriyati; Susanto, Joko Prayitno

    2016-01-01

    Sebagian besar industri makanan, termasuk industri tahu membuang limbah cairnya yang mengandung bahan organik dengan kadar tinggi (lebih dari 16,483 mg/L) langsung ke badan air. Dengan menggunakan teknologi yang tepat, limbah cair ini dapat diolah lebih lanjut untuk menghasilkan produk samping berupa biogas yang mengandunggas methan sebagai substitusi energi pada industri yang bersangkutan. Desa Kalisari merupakan salah satu sentra industri UKM tahu, untuk mengolah limbah cair yang dihasilkan...

  14. Modifikasi Blade Pencampur Pada Alat Pencampur Bahan Secara Mekanis

    OpenAIRE

    Nasution, Budiman Syahputra

    2011-01-01

    The agriculture equipment and machine has been operated since long time ago and their development were keep in touch with the development of human culture. Mixing is the distribution of one component to another. The mechanical mixing equipment has been designed to help the proses of mixing . The blade modification increase the capacity of mixing equipment and make the flow of material easier. The capacity of the equipment was 31,6 kg/hour, the percentage of imperfect mixing material was ...

  15. Perekayasaan mesin injeksi bakalan acuan sepatu secara sederhana

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    Agustin Suraswati

    1995-06-01

    Full Text Available Engineering of the injection molding machine to mold a master last made of plastics was done in the simple mechanism. Machine specification is a single screw, screw diameter 40 mm, ratio L/D = 24/1, heater 220/380 V. 700 W, motor 5,5 Hp, capacity 500 cm3/ minute.

  16. Kajian Rumput Vetiver Sebagai Pengaman Lereng Secara Berkelanjutan

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    Susilawati Susilawati

    2016-12-01

    Full Text Available Flores is the island in the NTT province, which has a row of volcanoes, with the mountainous topography. Transportation is state road, along the coast with high cliffs on the other side. That often causes problems during the rainy season as several landslides. Various methods are used to overcome this landslide. Studies on vetiver grass as slope protection done to secure the slopes on a sustainable basis. First, an evaluation done for the slope construction along the slope safety from Nangaroro to Aegela, which are using vetiver grass as a safety slopes in addition to other security structures. It is also done for the same job of the road from Ende to Nangaroro and Ende-Detusoko. This study covers the technical aspects, ecological, construction and sustainability of the infrastructure that has been built. Furthermore, it is done the literature study to find more appropriate method, environmentally friendly and sustainable in securing these slopes problematic. From the literature studies and the field survey done, it can be concluded and recommended several models of eco-friendly structural design of vetiver grass and geotextile for slope protection, which is based on technical-meet standard strength, ecologically-friendly environment, locally-developed local wisdom, so it is easy to construct.

  17. EFEK PEMBERIAN PAKLOBUTRAZOL PADA ANGGREK Vanda tricolor SECARA IN VITRO

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    Ni Wayan Deswiniyanti

    2018-03-01

    Full Text Available Vanda tricolor Lindl. Var. Suavis forma Bali has a specific character than the forma Merapi and forma West Java that is size of flowers and fruits, spots purple in labellum purple colored labelum and floral fragrance. High genetic diversity is one of the major factors in breeding improvement. Increasing the diversity of orchid plant characteristics can be done by giving paclobutrazol. Treatment by paklobutrazol in culture medium aims to inhibit growth both in number of leaves and shoot length so that the plant becomes smaller size than their parent or original. The result of growth resistance that occurs varies based on the concentration of paclobutrazol added to medium Vacint & Went (VW in culture of seeds V. tricolor orchid added with coconut water with concentration of paklobutrazol Control K0 (0%, K1 (1mg / l, K2 (3mg / l, K3 (5mg / L, and K4 (7mg / l. Each treatment performed 5 times repetition. The result of planting of Vanda tricolor seed explants with paclobutrazol modification in vitro was found 40% cultured imbibition and then protocorm, 8% browning on seed, and 52% contamination. This study showed descriptively the orchid seed Vanda tricolor responded to Vacint and Went (VW media which was added with plant growth regulator of paklobutrazol, so that it was able to grow and develop until reaching phase 1 that seeds to form protocorm, but statistically the addition of plant growth regulator of paklobutrazol has not show a significant influence on the growth and growth response of orchids Vanda tricolor (P> 0.05 because the observation time is not sufficient for at least 6 months of observation and see the function of paklobutrazol is to slow the growth. Keywords :Vanda tricolor, paclobutrazol, in vitro, vacin went, protocorm

  18. PEMBUATAN PUPUK FOSFAT DARI BATUAN FOSFAT ALAM SECARA ACIDULASI

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    Faleh Setia Budi

    2012-02-01

    Full Text Available Phosphate rock containing P2O5 can be used as raw material of phosphate fertilizer. Phosphate rock canbe found in many areas in Indonesia, but its P2O5-content is relative low. In this research, phosphate rockfrom Rembang (P2O5-content 11.37% is used as raw material for phosphate fertilizer production byacidulation process using phosphoric acid solution. Operation variables are phosphoric acid concentration(10, 20, 30, 40 %-vol, spraying model of phosphoric acid solution (one hole and many holes, andspraying position of phosphoric acid solution (end, centre, end & centre. The result shows that theincrease of phosphoric acid concentration is proportional to P2O5-content in phosphate fertilizer withhighest P2O5-content in the amount of 18.29%. One-hole spraying model and end-position spraying giveshighest phosphate fertilizer yield in amount of 169.5 grams.

  19. Uji Penghambatan Xantin Oksidase Secara In Vitro Ekstrak Kulit Rambutan

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    Nurul Eka Putri

    2016-04-01

    Full Text Available Hyperuricemia is a condition that uric acid levels increased and cause accumulated uric acid crystals in the tissues. Xanthine oxidase is an enzyme which catalyze the oxidation of hypoxanthine into xanthine and into uric acid. Therefore, the inhibition of xanthine oxidase will reduce ammount of uric acid. The purpose of this study was to determine xanthine oxidase inhibition activity and to identify chemical constituent of rrind rambutan (Nephelium lappaceum Linn.. Rind of Rambutan was extracted using maceration methods, based on polarity the solvent are n-hexane, ethyl acetate and methanol. The test of inhibition xanthine oxidase activity used a spectrophotometer at λ = 274.79 nm, pH 7.8, substrate concentration of xanthine 0.15 mM and incubation temperature of 30°C. Allopurinol as positive control had C50 0.15 μg/mL. The result showed that methanol extract of rind rambutan had the highest inhibition with IC50 3.71 μg/mL. Phytochemical screening showed that the most active extract methanol of rind rambutan contain flavonoids, saponins, tannins and terpenoids.

  20. Pemantauan Parameter Panel Surya Berbasis Arduino secara Real Time

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    Muhammad Rizal Fachri

    2015-09-01

    Full Text Available Monitoring the output parameters of a solar module is required for assessing its performance under real operating conditions. This paper presents a new technique for monitoring the output parameters i.e. current and voltage of a solar module directly under real operating conditions. In this new monitoring technique, the output parameters of a solar module can be directly processed in real time condition and their results are displayed in a graph. The monitoring system is developed using microprocessor Arduino Atmega 328P and equipped with calibrated current and voltage sensors, a data acquisition system which is integrated directly into an Excel spreadsheet using the PLX-DAQ application program and a memory card for backup. The monitoring system is connected to a computer using a RS232 serial port. The collected data is saved directly into a spreadsheet and plotted in real time. This technique provides an easy access to the collected data for further analysis.

  1. Peningkatan Kompetensi Guru Menuju Pelaksanaan Dan Tanggung Jawab Secara Mandiri

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    Muhammad Lukman Syafii

    2016-03-01

    Full Text Available Teacher competency standards include pedagogical, personal, professional and social competences. In line with the global challenges of life, the roles and responsibilities of teachers in the future will become more complex, so it requires teachers to constantly perform various improvements and adjustments in the mastery of their competences. To add to the quality standards of teachers, Kemdikbud will propose three teacher training patterns, e.g. competency testing, Penilaian Kinerja Guru (PKG, and training on an ongoing basis and sustainable (PKB. One of the many activities of PKB for self-development is the activities performed by the teacher independently and carried out by teachers in collaboration with other teachers in the school. Implementation of this activity is relatively more independent and different from one teacher to another teacher in the school, as well as between oneto another school. Technically, this activity is not set by default. It is very likely to cause a variety of problems for teachers, perhaps even confusion can arise. All of which is feared will lead to the counter-productive, particularly with regard to achievement standards to increase the competence of teachers should meet the need independently.

  2. MUTU GIZI DAN KEAMANAN BEKASAM PRODUK FERMENTASI IKAN TERI SECARA SPONTAN DAN PENAMBAHAN KULTUR MURNI

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    Uken SS Soetrisno

    2012-11-01

    Full Text Available ABSTRACTBackground: Many kind of foods based on fermentation products are used as traditional foods in Indonesia. Such products are tape the sweet fermented cassava as source of carbohydrates, tempe the delicious fermented soybean or other beans as source of  protein, dadih the sour fermented buffalo milk as source of calcium and protein, and many others made of  animal protein source such as from small fish. Fermentation of foods will increase the nutrient content and absorbability of the nutrient, besides will increase sensoric or acceptability value of the products. Objectives: The study objectives are to evaluate the nutrient quality and sensoric quality of  the salt-fermentation product of small fish, so called teri, both using spontaneous fermentation and selected culture-fermentation those producing lactic acid bacteria. Methods: This was a food experimental study to explore the quality improvement  of acid bacteria fermentation products using spontaneous or sellected culture on protein source foods. Ingredients were consist of small fish with steam rice at 1 to 1 by weight with addition of salt at 5-6% and fermented spontaneously or with addition of 1% level selected culture, which contain lactic acid producing bacteria. Fermentation were done for 4 to 5 days, depent on the type of culture. Results: Bekasam produced from both type of fermentation had lower protein content due to the addition of rice as carbohydrate source, while ash content became higher due to the addition of NaCl salt. The products had sweet smell besides sour taste due to carbohydrate fermentation which could increase the absorbability of the products especially vitamins and minerals those needed lower pH. Generally, fermented bekasam had higher vitamin content and changed fatty acid composition. Vitamin B12 increased by 2 folds and vitamin A by 3-4 folds, compared with those of fresh small fish. Linoleic acid increased by 2-4 folds followed by decreased of other long chain fatty acids content. Pathogenic microorganisms were still high in raw fermented products, but they were  undetected after steaming for 30 minutes. Conclusions: Nutrient contents of the fermentation products, such as vitamin A, B12, linoleic acid were higher than the fresh fish, while the proximate nutrient content depent on the amount of ingredients added as the base component. All fermentation products contained E. coli, Koliform, and Shigella s., these might come from the fish that had been polutted since in the ocean. After steaming or sterillization the product, those pathogen microorganisms were negative or undetected. Based on the nutrient quality, it will be worthwile to develop local food formula using bekasam the fermented teri, for children under five years old. [Penel Gizi Makan 2005,28(1: 31-35] Keywords: fermentation, spontanious, sellected culture, small fish, bekasam.

  3. Penentuan Unsur Tanah Jarang Kelompok Sedang secara Voltammetri Pindai Linier Menggunakan Elektrode Grafit Pensil

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    Yeni Wahyuni Hartati

    2016-01-01

    Full Text Available Rare earth elements play an important role in a variety of applications, mostly for high-tech industries. But their presence in mineral jointly separation makes it difficult to determine the content of rare earths because each element has physical and chemical properties are almost identical. The purpose of this study is the use of a linear scan voltammetry method to study the electrochemical characteristics of the medium rare earth element group (Sm, Gd, Eu, Tb, as an alternative method of separation and analysis of rare earth elements. The electrode used is a graphite pencil electrodes without modification, with a variety of supporting electrolyte. The results obtained show some supporting electrolyte provides good reduction peak for gadolinium, compared to the peaks of the reduction potential of the single rare earth ions other. The potential range of the most well using pencil graphite electrode obtained at 0.50 V to -1.00 V. Analysis of single gadolinium provide linear regression equation in a concentration range of 4.0 to 10.0 mg/L by the equation Y = 0.9862 X + 0.828 with R2 = 0.9954. The limit of detection is determined from the linear regression obtained 0.72 mg / L.

  4. Pengaruh Eksplan Dan Zpt Terhadap Pertumbuhan Nepenthes Albomarginata Secara in Vitro

    OpenAIRE

    Sukamto, Lazarus Agus

    2011-01-01

    Nepenthes albomarginata Lobb ex Lindl. is a carnivorous plant, distributes in several regions in Indonesia. The plant population decreases drastically because of over exploitation and ruining nature habitat. Plant propagation by nature and cutting are not enough to rehabilitation its population. In vitro culture of N. albomarginata was carried out using plantlets grown from the seeds in vitro. Plantlets were cut to became two part explants, consisted of shoot tip and under-shoot tip cuttings....

  5. Urgensi Pemilu Presiden dan Wakil Presiden Secara Langsung di Era Reformasi

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    Abu Tamrin

    2016-04-01

    Full Text Available Abstract: the Importance of Direct Presidential and Vice Presidential Election in Reformation Era. Direct president and vice president election has begun in 2004 based on Act Number 23 Year 2003and renewed by Act Number 42 Year 2008. The importance of this provision is that elected president and vice president reflect the choice of majority of people. Beside of preventing problems in Parliament, this provision is also aimed to keep the sustainability of President both as head of government and head of State So,  it would not be easy for him to be removed or impeached. DOI: 10.15408/jch.v1i2.2990

  6. Perancangan Model Pengukuran Kinerja Lean dan Green Rantai Pasok Semen Secara Terintegrasi

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    Dina Rahmayanti

    2017-05-01

    Full Text Available Abstract PT. Semen Padang is one of the reputable cement companies in Indonesia which is producing types of cement. Implementation of supply chain concept in PT. Semen Padang is very important to satisfy customers and stakeholders requirement. Performance measurement is a process to evaluate the supply chain effectiveness and efficiency in lean and green aspect. The problem is how to design performance measurement model which is integrating lean and green supply chain concepts. The objective of research is integrating lean and green supply chain concepts to design supply chain performance measurement of bag cement type. Integration of lean and green concept is designed by Balanced Scorecard (BSC perspectives that consist of financial, customer, internal process business and learning and growth. Key performance indicators (KPI are formulated and classified based on BSC perspectives. Next stage is pair wise comparison process to the weight value. Evaluation of KPI pair wise comparison based is conducted on expert opinion which is selected by consideration of their relevance knowledge and experience. The process of pair wise comparison is calculated to determine priority of the KPIs based on weight value by using Analytical Hierarchy Process (AHP method. The weight of KPI will be arrange by descending to determine the priority. Model of performance measurement is validated by face validity method. Research result is obtaining 25 KPIs that derived from integration of lean and green supply chain concept of bag cement type. Grouping is consisting of 3 KPIs of financial, 4 KPIs of customer, 11 KPI s of internal process business and 7 KPI s of learning & growth. Result is showing that customer is most prioritized element in supply chain of bag cement type. Implementation of proposing model is coordination of departments and employee in context of information accessibility. Keywords: Supply chain, lean, green, BSC, performance measurement

  7. Produksi Hidrogen Secara Fotokalitik dari Air Murni Pada Katalis NaTaO3

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    Husni Husin

    2012-12-01

    Full Text Available Study of hydrogen production as a green energy on NaTaO3 photocatalyst has been done. The aim of this work is to study the photocatalytic properties of NaTaO3 and NiO incorporated NaTaO3 used in water splitting reaction. The NaTaO3 powder with high crystallinity has been synthesized by a H2O2-asissted sol-gel route calcined at a temperature of 900 oC. NiO as a cocatalyst is deposited by impregnation of Ni(NO32.6H2O solution. The catalysts are characterized by X-ray diffraction (XRD, scanning electron microscopy (SEM, high resolution transmission electron microscopy (HRTEM, and diffuse reflectance UV-Vis (DR-UV-Vis. The photocatalysts have a band gap energy ca. 4.01 and 4.00 eV (corresponding to absorption edge of 310 and 311 nm. Photocatalytic activity towards hydrogen generation from water is investigated using a glass reactor under ultra violet (UV light illumination. Photocatalytic of H2 and O2 production on the pristine NaTaO3 are 0.61 and 0.30 mmol g-1 cat.h-1, respectively. The activities are greatly enhanced 8.5 times higher by the incorporation of NiO as cocatalysts on the prepared oxides. NiO is found to give rise to more efficient photocatalytic activity for hydrogen evolution. The NaTaO3 nanoparticles produces using this facile have: better crystallinity, smaller size, and higher photocatalytic activity. Keywords: Sodium tantalum oxide; Nickel oxide; Sol-gel; impregnation; Hydrogen evolution

  8. Proses Kerja Komputer yang dapat Mengoptimalkan Hasil Komunikasi Visual secara Efisien

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    Andreas James Darmawan

    2010-10-01

    Full Text Available  To be able to work optimally and efficiently by computer, in making a visual communication, we need to understand the three kinds of process/ how to work a computer. There are three bases logic how computer works, such as text, pixel, and vector. Each made with different methods of logic, as a result of efforts to meet the needs of creators of computer communication. So after the third understands the workings of TSB, the ease and optimization in making a visual communication can be achieved.  

  9. PENENTUAN BAHAN KERING BUAH SAWO SECARA TIDAK MERUSAK MENGGUNAKAN NIR SPECTROSCOPY

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    Diding Suhandy

    2012-12-01

    Full Text Available This work was conducted to develop a new measuring system for nondestructive dry matter prediction in sawo fruit using short wavelength near infrared (SW-NIR spectroscopy. In this research, a number of 100 sawo fruits were used as samples. Spectra were acquired using a portable spectrometer (VIS-NIR USB4000, The Ocean Optics, USA with 100 ms integration time and 50 scans for number of scanning. Dry matter was measured using oven drying. The calibration and validation model was developed using the partial least squares (PLS regression method. The result showed that the best calibration model could be developed for original spectra in the wavelength range of  700-990 nm with F= 8, r = 0.92, SEC = 0.68 and  SEP = 0.86. Keywords:   Absorbance mode, dry matter, nondestructive method, sawo fruit, SW-NIR spectroscopy.

  10. Pengembangan Model Economic Production Quantity (EPQ dengan Sinkronisasi Demand Kontinu dan Diskrit Secara Simultan

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    Nurike Oktavia

    2016-04-01

    Full Text Available The most popular inventory model to determine production lot size is Economic Production Quantity (EPQ. It shows enterprise how to minimize total production cost by reducing inventory cost. But, three main parameters in EPQ which are demand, machine set up cost, and holding cost, are not suitable to solve issues nowadays. When an enterprise has two types of demand, continue and discrete demand, the basic EPQ would be no longer useful. Demand continues comes from a customer who wants their needs to be fulfilled every time per unit time, while the fulfillment of demand discrete is at a fixed interval of time. A literature review is done by writers to observe other formulation of EPQ model. As there is no other research can be found which adopt this topic, this study tries to develop EPQ model considering two types of demand simultaneously.

  11. PENGARUH SUMBER MINERAL TERHADAP PENEKANAN Erwinia carotovora OLEH PSEUDOMONAS PENDAR-FLUOR SECARA IN VITRO

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    Hardian Susilo Addy .

    2012-02-01

    Full Text Available Antimicrobial Stimulation of Fluorescent Pseudomonad to Inhibit Soft-rot Pathogen Caused by Erwinia carotovora subsp. Carotovora. This research was conducted to study effect of mineral sources on inhibition Erwinia carotovora by fluorescent pseudomonad. We used several mineral sources to stimulate antimicrobial substances from fluorescent pseudomonad that responsible to inhibit E. carotovora subsp. carotovora in vitro. The results showed that zinc 0,5 mM were the best to increase antagonistics of fluorescent psudomonad againts E. carotovora. Zinc were increased antimicrobial substances twohold compared with control without stimulant agent. Detection of antimicrobial substance using TLC showed that only one antimicrobial was detected with retention factor (Rf of 0,68 – 0,72. However, identification and characterization of that substance is still needed.

  12. Pengurangan Kadar N dan P pada Limbah Cair Laboratorium secara Fitoremediasi Menggunakan Enceng Gondok (Eichornia crassipes

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    Nurmaya Arofah

    2016-03-01

    Full Text Available Laboratory liquid waste contains both metal, nonmetal, organic and anorganic content. If it is discharged directly to environment, it will cause pollution that is harmful for living thing. Data of waste survey result in 2009-2010 indicated that liquid waste of Laboratory in Chemical Engineering Department, Gadjah Mada University (JTK UGM consist of various complex compound such as NH4+, PO43-. JTK UGM has wastewater treatment plant (WWTP to deal with environmental pollution coming from waste of each laboratory and have three process, anaerobe activated sludge, aerobe and phytoremediation. Because the laboratory’s waste was very complex, the WWTP have not operated maximally yet. So, it is necessary research on wwtp processing step, particularly for phytoremediation process using water hyacinth. Objective of this research was to study effect of concentrations N and P on adaptability and capability of water hyacinth to grow. In addition it developed a mathematical model to estimate of N and P concentration decrease rate in liquid. The research was done in batch by planting water hyacinth that has been acclimated in wastewater containing N-NH4OH and P-H3PO4. Parameter observed is N and P concentration in liquid. The result indicated that water hyacinth can absorb N and P. Water hyacinth grow well in N-NH4OH concentration of 9.651 ppm and 15.573 ppm and P-H3PO4 concentration of 2.013 ppm and 2.7373 ppm. It was marked with additional weight and colour of water hyacinth leaves of fresh green. Mathematical model presented to estimate N concentration decrease rate indicated good result in experiment. However, P concentration decrease in liquid phase, the presented model is still not good, because P nutrient decomposition process has not been accommodated during absorption by water hyacinth.

  13. Penetapan Kadar Rifampisin dan Isoniazid dalam Sediaan Tablet Secara Multikomponen dengan Metode Spektrofotometri Ultraviolet

    OpenAIRE

    Hastia, Faula

    2011-01-01

    Tuberculosis is the most deadly infectious diseases and the number two cause of death after heart disease. The number of tuberculosis patients in Indonesia as many as 583,000 people, China 2 million and 1.5 million Indians. Combination of rifampicin and isoniazid in the tablet is one of the drugs which is usually use for TBC treatment. The aim of this study is to determination value of rifampicin and isoniazid in the tablet which circulates in the general by ultraviolet spectrophotometry. ...

  14. Analisis Sistem Proses Pindah Massa pada Ekstraksi secara Mekanik Minyak Kedelai (Glycine Max Oil

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    Bambang Dwi Argo

    2010-10-01

    Full Text Available Soybean, a vegetable protein-rich commodity needed to improve public nutrition, safe to consume, and the price affordable. The purpose of this research are to: 1. determine the effect of pressure and time of extraction the mass balance, yield and level of soybean oil extraction, 2. Gain mass transfer coefficient value in soybean oil extraction process, and 3. analyze the mechanism of mass changes during the extraction process soybean oil is mechanically using hydraulic pressing. Oil obtained results indicate an increase due to the influence of a given amount of pressure and length of time silenced. The greater the pressure exerted, the more oil produced this shows soybean oil can come out with a maximum at the greatest pressure of 200 kg/cm2. Mass transfer coefficient in soybean oil extraction process at a pressure of 100 kg/cm2 5.57x10-5 gcm3/cm seconds. In the pressure is 200 kg/cm2 15.39 x 10-5g cm3/cm seconds.

  15. Kompatibilitas Jamur Entomopatogenik Paecilomyces fumosoroseus dengan Beberapa Bahan Aktif Pestisida Secara In Vitro

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    Fani Fauziah

    2016-12-01

    Full Text Available Untuk mengurangi penggunaan pestisida di perkebunan teh, maka salah satu upaya pengendalian hama yang dapat dilakukan adalah mengkombinasikan aplikasi pestisida dengan jamur entomopatogenik. Penelitian ini bertujuan untuk mengetahui kompatibilitas antara jamur P. fumosoroseus  dengan beberapa bahan aktif pestisida di laboratorium. Perlakuan dirancang dengan Rancangan Acak Lengkap (RAL terdiri dari 5 jenis bahan aktif yaitu metomil, bifentrin, imidakloprid, tembaga oksida dan metidation pada taraf konsentrasi sesuai rekomendasi lapang (RL, 0,5x RL dan 2x RL. Hasil pengamatan menunjukkan bahwa diantara kelima jenis bahan aktif pestisida yang diuji, metidation memiliki tingkat toksisitas yang paling tinggi. Persentase produksi spora tertinggi sebesar 13,77% ditunjukkan oleh perlakuan bifentrin 2x RL. Combining application of pesticides and entomopathogenic fungi is an alternative way for controlling pest in order to reduce pesticides application in the tea field. This research was aimed toexamine the compatibility of Paecilomyces fumosoroseus tosome active agents of pesticide in laboratory. Completely Randomized Block Designed (CRBD with 5 active agents: methomyl, bifenthrin, imidacloprid, copper oxide and metidation in three different concentration was employed in this study, which was based on the existing field recommendation (FR: 0,5x FR and 2x FR. The results showed that among the five tested pesticides, metidation appeared to be the most toxic agentto P. fumosoroseus. Meanwhile, the highest percentage of spore production was counted in bifenthrin 2x RL (13,77%.

  16. PEMBUATAN KALSIUM KARBONAT DARI BITTERN DAN GAS KARBON DIOKSIDA SECARA KONTINYU

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    Soemargono Soemargono

    2012-01-01

    Full Text Available Kalsium karbonat  yang  digunakan  dalam  industri- industri cat, karet, dan  kertas  harus  mempunyai  mutu yang  tinggi, terutama  kemurnian  dan kehalusannya.Untuk itu, Indonesia masih  mendatangkan  kalsium  karbonat murni dari luar negeri dalam jumlah yang cukup besar. Bittern merupakan bahan buangan industri garam yang disebut juga air tua, mengandung senyawa kalsium. Karbon dioksida biasanya berasal dari hasil pembakaran yang masuk ke udara. Kandungannya di udara kecil, tetapi berpotensi sebagai pencemar. Dengan mereaksikan kalsium yang terkandung dalam bittern dengan gas CO2 akan terbentuk CaCO3 dalam suasana basa. Pembentukan kalsium karbonat dilakukan dengan proses kontinyu dalam reaktor kolom bersekat miring. Dari hasil penelitian diperoleh bahwa pengendapan magnesium dengan larutan ammonia menyebabkan kandungan kalsium ikut terdegradasi. Hasil terbaik yang diperoleh dicapai pada kondisi pH awal, kecepatan alir gas CO2, kecepatan alir cairan, dan suhu masing-masing pada 8,7; 2265 mL/menit; 10 mL/menit; dan 303 K, dengan konversi sebesar 38,40%. Produk berupa CaCO3, yang diperoleh mempunyai kemurnian sebesar 21,34%.

  17. EFISIENSI CONSTRUCTION WETLAND TYPHA SP. SEBAGAI PENGOLAH AIR LIMPASAN JALAN RAYA SECARA ALAMI

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    Rudatin Windraswara

    2011-02-01

    Full Text Available Penelitian ini bersifat desain eksperimental pada skala laboratorium untuk mengetahui kemampuan Typha latifolia. sebagai tanaman wetland dalam mereduksi BOD dan COD yang berasal polutan air limpasan jalan raya sebagai bagian dari sistem drainase yang berkelanjutan. Sampel dalam penelitian ini adalah air limpasan jalan yang berasal dari air hujan yang kemudian masuk ke saluran pengumpul (drainase jalan. Habitat wetland disimulasikan menggunakan kolom dengan tabung yang memiliki volume kosong 20 liter. Susunan tabung adalah sebagai berikut; tanaman wetland, air, pasir dan batu kerikil. Satu tabung lagi akan berlaku sebagai kontrol dengan susunan yang sama tanpa tanaman wetland. Desain tabung memiliki spesifikasi sebagai berikut bahan acrylic dengan ukuran diameter 9,7 cm, tinggi 40 cm, volume 20 liter, media pasir setinggi 10 cm, kerikil 15 cm, kemudian diisi air setinggi 15 cm dari batas kerikil. Nilai BOD dari sampel kontrol setelah hari ke-3 menjadi 87 mg/l dari nilai semula 104 mg/l sedangkan nilai BOD dari sampel uji setelah hari ke-3 menjadi 44 mg/l dari nilai semula 104 mg/l. Hasil ini menunjukkan tanaman tersebut mampu menghilangkan nilai BOD sebesar 65% atau BOD removal sebesar 65%. Nilai COD dari sampel kontrol setelah hari ke-3 menjadi 309 mg/l dari nilai semula 210 mg/l sedangkan nilai COD dari sampel uji setelah hari ke-3 menjadi 87 mg/l dari nilai semula 210 mg/l. Hasil ini menunjukkan tanaman Typha latifolia mampu menghilangkan nilai COD sebesar 58,6% atau COD removal sebesar 58,6%. Kedua parameter tersebut telah sesuai dengan baku mutu Kepmen LH no 112 tahun 2003 dan Kepmen LH no 51 tahun 1999.

  18. Pendekatan Pendidikan Nilaj secara Komprehensif sebagai suatu Alternatif Pembentukan Akhlak Bangsa

    OpenAIRE

    Darmiyati Zuchdi, Darmiyati Zuchdi

    2001-01-01

    The eclining quality of the Indonesian character needs to be resolved. One of the ways to solve this problem is through the educational practice, by using a more effective approach. A single approach of values education is considered to be ineffective, that is why it is needed a comprehensive one. The development of students' personality should be holistic in nature, including the intellectual, emotional, and spiritual intelligence. Four important substances of values education...

  19. Pengukuran Kapasitas Antioksidan Dalam Rimpang Temulawak (Curcuma Xanthorrhiza Roxb.) Secara Spektrofotometri Sinar Tampak

    OpenAIRE

    Maggie

    2015-01-01

    One of Indonesia’s top natural product, Java turmeric (Curcuma xanthorrhiza Roxb), is very strategic to be developed, considering the benefits demonstrated by one of its active compound which is polyphenols. The presence of the phenolic group leads to strong antioxidant activity in biological systems, therefore could prevent diseases associated with reduction-oxidation reaction. The purpose of this study was to determine the antioxidant capacity in Java turmeric dosage form in the market and...

  20. EFEK EKSTRAK METANOL DAUN ENGKUDUK TALUN (FAGRAEA RACEMOSA PADA PEROKSIDASI LIPID SECARA IN VIVO

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    Ika Fikriah

    2011-06-01

    Full Text Available ABSTRACT   Engkuduk talun plant (Fagraea racemosa grows in East Kalimantan forest. Stages Extraction research of petroleum eter-cloroform-metanol from leaves, root skin, root, stem skin and Fagraea racemosa’s stem toward radical 2,2-diphenyl-1-picrylhydrazil (DPPH is proven that the extract of methanol leaves have the strongest scavenger effect, this can be interpreted that the leaves have the strongest antioxidant potency from all plant parts that have been examined.  The given single dose 1 gram/kg b.w of the methanol extract from Fagraea racemosa leaves do not caused the death at the female Wistar rats. On the inhibitor test of forming MDA of rat’s liver the very high of absorbance value has accurred on control by CCl4 ( 0.508 ± 0.039 , significant if compared to CCl4 added with the vitamin E ( 0.224 ± 0.006 and CCl4 added with three doses of methanol extract from the Fagraea racemosa’s leaves ( p=0.000   Keywords: Fagreae racemosa, lipid peroxidation, CCl4,  vitamin E   ABSTRAK Tumbuhan engkuduk talun (Fagraea racemosa banyak terdapat di hutan Kalimantan Timur. Penelitian ekstraksi bertingkat petroleum eter-kloroform-metanol dari daun, kulit akar, akar, kulit batang dan batang Fagraea racemosa terhadap pereaksi radikal 2,2-diphenyl-1-picrylhydrazil (DPPH terbukti pada ekstrak metanol daun mempunyai efek peredaman paling kuat, ini dapat diartikan daun mempunyai potensi antioksidan yang paling kuat dari semua bagian tumbuhan yang diamati. Pemberian dosis tunggal 1 gram/kgBB ekstrak metanol daun Fagraea racemosa tidak menunjukkan kematian pada hewan coba tikus Wistar betina. Pada uji hambatan  pembentukan MDA hepar tikus terjadi peningkatan nilai absorbansi yang sangat tinggi pada kontrol dengan CCl4 (0.508 ± 0,039, berbeda bermakna jika dibandingkan CCl4 yang ditambah dengan vitamin E (0.224 ± 0,006 dan CCl4  yang ditambah dengan tiga dosis ekstrak metanol daun Fagraea racemosa (p=0.000.   Kata Kunci: Fagraea racemosa, peroksidasi lipid, CCl4, vitamin E

  1. Validasi Metode HPLC untuk Penetapan Aspirin dan Asam Salisilat dalam Plasma Kelinci (Lepus curpaeums secara Simultan

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    Agus Siswanto

    2017-02-01

    Full Text Available Aspirin is a nonsteroidal anti-inflammatory drug which also has the effect of antiplatelet for stroke prevention. Aspirin inside human body is very easy to break down into salicylic acid as the main metabolite. The aim of this study is to develop and validate the method for determinating aspirin and salicylic acid concentration in plasma by HPLC. Method validation including system suitability test, linearity test, determination of LOD and LOQ, recovery, accuracy and precision. Concentration of analytes in blood is measured by HPLC using benzoic acid as internal standard, with condition Purospher column Endcapped Star RP-18 (250 x 4.6 mm id, 5 m, acetonitrile : buffer phosphate 20 mM pH 2.5 (30:70 v/v as mobile phase, injection volume 20 mL, flow rate 1.5 mL/minute, and UV-Vis detector λ 230 nm. The results showed that the proposed method meets the requirements of system suitability and good linearity (r > 0,990 with LOQ (aspirin = 0.024 mg/mL, salicylic acid = 0.336 mg/mL and LOD (aspirin = 0.007 mg/mL, salicylic acid = 0.101 mg/mL. The method of analysis provides recovery of 85-115 %, accuracy and precision in accordance with the requirements for bioanalytical with CV < 5 %. Therefore, the proposed method is applicable to determine of aspirin and salicylic acid concentration in plasma.

  2. Akibat Hukum Pemutusan Perjanjian Franchise Secara Sepihak Oleh Franchisor Sebelum Berakhirnya Kontrak

    OpenAIRE

    Lannemey, Lannemey

    2015-01-01

    Bisnis franchise merupakan suatu sistem di mana pihak franchisor memberikan lisensi menggunakan hak kekayaan intelektual seperti hak cipta, merek, paten serta rahasia dagang kepada franchisee. Sebaliknya pihak franchisee berkewajiban untuk membayar royalty fee. Perjanjian franchise merupakan hubungan hukum antara franchisor dan franchisee yang memuat hak dan kewajiban yang menimbulkan akibat hukum bagi para pihak. Dalam pelaksanaan perjanjian franchise sangat rentan terjadi permasalahan sepe...

  3. Faktor Penyebab dan Sanksi Tindak Pidana Penipuan Kepemilikan Kendaraan Bermotor Secara Melawan Hukum

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    Elvi Zahara Lubis

    2017-12-01

    Full Text Available One form of crime that increasingly has a certain modus operandi is a crime of motor vehicle fraud unlawfully. Fraud is a crime that belongs to a class devoted to property rights and other rights arising from rights. As formulated in Article 378 of the Criminal Code, fraud means deeds with the intent to benefit themselves or others unlawfully by using false names, false dignity, deceit or lies that may cause others to easily surrender their goods, money or wealth. Factors causing the crime of motor vehicle ownership fraud unlawfully are caused by four factors namely economic factor, desire factor, opportunity factor and the weak factor of faith. Sanctions against perpetrators of criminal fraud of motor vehicle ownership by unlawful means in the form of criminal punishment of imprisonment to perpetrators for 4 years. Such sanctions may be applied if the perpetrator has been proven to commit a criminal act of fraudulent vehicle ownership in a manner which is against the law.

  4. Pengukuran Tingkat Efektivitas Kinerja UMKM Batik Bakaran Secara Berkelanjutan Mengunakan Model Green SCOR

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    Daniel Alfa Puryono

    2017-09-01

    Full Text Available Usaha Mikro Kecil dan Menengah (UMKM merupakan salah satu kekuatan pendorong terdepan dalam pembangunan perekonomi di Indonesia. Agar UMKM tersebut tetap mampu bertahan dalam menghadapai tantangan sekaligus peluang yang ada, maka UMKM harus bisa meningkatkan kinerja dan kerja sama dengan sektor usaha yang lainnya. Selain itu UMKM tersebut juga harus tetap memperhatikan dampak terhadap linkgungannya. Untuk itu maka diperlukan adanya pengukuran tingkat efektivitas kinerja dalam UMKM tersebut. Supaya bisa menjadi tolak ukur maupun penetuan arah kebijakan kedepanya. Serta bisa memastikan bahwa semua faktor dalam usaha tersebut tidak menimbulkan pencemaran serta dampak sosial ekonomi bagi lingkungannya. Metode yang digunakan untuk menyelesaikan permasalahan pada penelitian ini mengunakan model Green Supply Chain Operations Refernece (Green SCOR. Model tersebut digunakan untuk menentukan kriteria serta tujuan sistem rantai pasok UMKM Batik Bakaran yang ramah lingkungan. Selain metode tersebut penelitian ini juga mengunakan metode Analitycal Hierarchy Process (AHP yang digunakan untuk menentukan Key performance Indikator (KPI yang mempengaruhi tingkat efektivitas kinerja UMKM Batik, serta dapat mengukur tingkat kinerja maupun proses kinerja dari masing masing kriteria tersebut. Sehingga akan menghasilkan tingkat efektivitas kinerja yang ramah lingkungan bagi UMKM Batik Bakaran. Model Green SCOR dan metode AHP mampu untuk menghubungkan semua kriteria kinerja yang ada. Kombinasi metode tersebut, terbukti mampu untuk memberikan penilaian tingkat efesiensi sebesar 65,4% dan profitability sebesar 34,6%. Green Supply Chain Management (GSCM merupakan kata kunci untuk meyakinkan bahwa semua faktor atau semua elemen dalam rantai pasokan memperhatikan lingkungannya atau tidak menimbulkan dampak berbahaya bagi lingkungan. Namun karena pengukuran dan penerapan GSCM yang begitu kompleks jadi tidak semua kriteria dapat diidentifikasi dan di hubungkan dengan keungulan kompetitif dari UMKM Batik tersebut

  5. PERENCANAAN PEMBANGUNAN GUGUS PULAU SAPEKEN SECARA BERKELANJUTAN: PENILAIAN DAYA DUKUNG KAWASAN BAGI PENGEMBANGAN WISATA

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    A Romadhon

    2013-08-01

    Full Text Available The challenge for planning in small island is to ensure efficient use of limited land resources, ensure balanced regional development and balanced use of resources, including natural resources and landscape resources. Based on carrying capacity and small island destination, spatial planning of tourism in Sapeken archipelago which contaian several small island, done by suitability analyze Sapeken archipelago for several tourism. Furthermore,carrying capacity calculated referring Yuliandaetal(2010 to assess how much tourism can commodate without causing disruption the nature. The result suggest Sapeken archipelago have suitable area for dive tourism (164.42 ha; snorkeling (361.56 ha; fishing tourism (1493.38 ha, mangrove tourism (3927.09 ha dan beach tourism (39.77 ha. Carrying capacity for tourism activities,Sapeken archipelago can commodate 4260 person/day for dive tourism; 3590person/dayfor snorkelling; 14 900people/day for fishing tourism; 321. 000people/day formangrovetoursm;and 199 people/day for beach tourism.

  6. ANALISIS KUANTITATIF ISOFLAVON TEMPE SECARA CEPAT DAN SEDERHANA MENGGUNAKAN METODE KROMATOGRAFI LAPIS TIPIS- DENSITOMETRI

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    Agustina Setiawati

    2014-05-01

    Full Text Available Abstract: Rapid and simple quantitative analysis isoflavones tempe using densitometric TLC has been done. The mobile phase of the system was chloroform: methanol: ethylacetate (45: 5: 0.75. Thin layer chromatography was performed on aluminium TLC plates.Ascending distance of 1 μL sample was performanced 10 cm. Then the plate was scanned at 261 nm. A linear relationship obtained at 0.08 - 2 μg/spot with r= 0.9986. The LOD and LOQ of isoflavone were 0.014 μg/spot and 0.048 μg/spot. Genistein contained in tempe was 0.151± 0.005 % b/b. Keywords: tempe, isoflavon, TLC

  7. TEMPAT PENITIPAN ANAK, MEWAH, MENENGAH DAN SEDERHANA (Studi Perbandingan Perkembangan Anak Balita Secara Kognitif Motorik Afektif

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    Listia Natadjaja

    2007-01-01

    Full Text Available The aim of this study is to observe the comparison of children cognitive, motorist and affective development in luxurious, middle and moderate day care center,, in order to obtain the description of a suitable day care center and its influence. All the population which is known and registered in Social Department are used, like: Teratai, Sandhy Putra, LKK, Dharma Wanita Day Care Center and also many private day care center like: Benih Kasih, St Yoseph and RKZ. The purposive sampling method is used to show that the aim of this technique is to reach the specific target. The examination result shows that there are differences in children development among the different day care center for cognitive and motorizes development, but only in certain ages. The Architectural element in luxurious, middle and moderate day care center is suspected to give effects in children development. Abstract in Bahasa Indonesia : Penelitian ini meneliti perbandingan perkembangan kognitif, motorik dan afektif anak balita di tempat penitipan anak yang tergolong mewah, menengah dan sederhana,sehingga didapatkan gambaran tempat penitipan anak yang sesuai dan bagaimanakah pengaruhnya. Penelitian ini menggunakan populasi sebagai obyek penelitian yang diketahui dan terdaftar di dinas sosial yaitu: TPA. Teratai, TPA. Sandhy Putra, TPA. LKK, TPA. Dharma Wanita, dan tempat penitipan swasta lainnya, yaitu: TPA. Benih Kasih, TPA. St. Yoseph, TPA. RKZ. Metode proposive sampling dipakai sebagai acuan yang menunjukkan bahwa teknik ini digunakan untuk mencapai tujuan-tujuan tertentu. Hasil penelitian ini menyatakan bahwa terdapat perbedaan perkembangan anak pada tempat penitipan anak yang berbeda untuk perkembangan kognitif dan motorik, namun tidak merata pada semua kelompok usia.Elemen arsitektur yang berbeda pada kategori mewah, menengah dan sederhana diduga berpengaruh pada tingkat perkembangan anak. Kata kunci: tempat penitipan anak, perkembangan anak, elemen arsitektur.

  8. PARTISIPASI KONTRAKTOR DI KOTA DENPASAR DALAM LELANG PENGADAAN BARANG DAN JASA PEMERINTAH SECARA ELEKTRONIK

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    I Md Suciptapura

    2013-07-01

    Full Text Available Electronic auction is an activity to provide goods / services by creating fair competition among providers of goods / services by complying with the principle of utilizing the facilities of communication and information technology. The purpose of this study was to determine the participation and acquisition of project contracting in the electronic auction to determine the relationship between the qualifications of the contractor, the contractor characteristics and conditions of participation in the electronic auction and acquisition projects, and to determine the factors that affect government contractors to participate in the auction. The study was conducted in the city of Denpasar. Methods of data collection using questionnaires and interviews addressed to contractors who have experience in the electronic auction. The method used is descriptive analysis, product moment correlation, regression and factor analysis using SPSS. The results showed that the characteristics of contractor availability factor of human resources project that comes with a certificate of availability of skilled experts and heavy equipment together to increase participation in the auction and acquisition projects. Lack of equipment auctions and bad internet connection is a factor that can degrade electronic participation and acquisition projects in the electronic auction. Factors affecting contractors to participate in the auction consists of 9 major factors such as: human resources and corporate confidence, and the location of the project, the contract system and auction system, Level Competition auction, capital and time, experience, government policies and economic conditions, The type and amount of equipment, construction market conditions

  9. Structural Assurance, Kepercayaan pada Sistem E-commerce dan Niat Bertransaksi Secara Online

    Directory of Open Access Journals (Sweden)

    Gandis Ayuningtiyas

    2011-08-01

    Full Text Available Structural Assurance, Trust and Intention to Make Online Transaction. The objective of this research is to examine some determinant factors that influence user intention to make online transaction by using the Theory Planned Behavior (TPB. This research done in Brawijaya University Malang. Researcher have got 264 respondents which is student of Brawijaya University and never done online transaction. Multiple regression technique was used in this analysis. The variables are structural assurance and trust. The result of analysis indicates that simultaneously, structural assurance and trust significantly influence to the intention to make online trans-action. The implication of this research is relevant toward on-line business sector to consider factors which influence the intention online transaction.

  10. Classroom Assessment: Bagian Integral Proses Pembelajaran Kejuruan Dalam Upaya Menyiapkan Tenaga Kerja Secara Holistik

    OpenAIRE

    Wagiran, Wagiran

    2011-01-01

    Assessment of student achievement needs to change, largely because today's students face a world that will demand new knowledge and abilities. In the global economy of the 21st century, students not only need to understand the basics, but also to think critically, to analyze, and to make inferences. In order to develop these skills, changes in assessment at school and classroom level are required. Classroom assessment is an effective strategy to improve the quality of learning to achieve the ...

  11. ANALISIS EKSTRAK TUMBUHAN REMPAH SEBAGAI PRESERVATIVES MAKANAN TAHU DIUJI SECARA IN VITRO

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    ni luh putu manik widiyanti

    2017-01-01

    Abstract Tofu is know as a traditional food and as a source of high quality protein that contains many essential amino acids and is proven to reduce levels of Low Density Lipoprotein. Tofu susceptible to decomposition by bacteria, because high of the protein content and water content.  But many food entrepreneurs that naughty by adding formalin and methanyl yellow dye that banned its use in food regulation by Minister of Health Num. 1168/Menkes/PER/X/1999 for the food preservatives of tofu. The alternative is an antibacterial plants and used as a natural food preservatives including Cymbopogan ciratus (lemongrass, Cucurma domestica (turmeric and Alpinia galanga (galangal to inhibit bacterial growth in tofu.  Tofu that has been created is still not meet the assessment standards of SNI 01-3142-1992 in aroma part, whereas 50% panelists who stated aroma tofu is slightly acidic. Organoleptic test of tofu in first day of soaked with natural preservatives, 100% panelists who stated tofu that soaked with three kinds natural preservatives with aroma and taste of Cymbopogon ciratus (lemongrass, Cucurma domestica (turmeric and Alpinia galanga (galangal extracts. The characteristic color  of tofu, 100% panelists expressed that tofu with pure white color or pure yellowish and 100% panelists who stated normal of tofu in performance without slimy and moldy. In fact characteristic of tofu is decrease of quality result from organoleptic test on day three and six both in aroma, taste, color and performance of tofu. Gain score result show that tofu soaked with natural preservatives lemongrass concentration 20% that show increase bacteria in number. On third and six days, tofu soaked with 40% and 60% concentrations of lemongrass inhibit growth of bacteria. Result gain score indicates  tofu that soaked with tumeric extract on first and sixth days soaked with 20%, 40% and 60% concentrations   show all of tumeric extract concentrations didn’t inhibit growth of bacteria. On the third day tofu that soaked with only 60% concentration capable to inhibit growth of bacteria.   Result gain score  indicates tofu that soaked with extract of galangal in first day, only concentration 40% show inhibit growth of bacteria. On third and sixth days, all of concentrations of galangal extract didn’t capable inhibit growth of bacteria. Number of SPC bacteria in tofu soaked with preservatives lemongrass with concentration 40% was significantly different with tofu that soaked extract of 20% concentrations of turmeric and galangal.  Number of SPC bacteria in tofu soaked with lemongrass concentration 60% was significantly different with 20% concentrations of both turmeric  and galangal, and 40% concentration of galangal. Number SPC of bacteria in tofu soaked with 20% concentration of turmeric was significantly different with 40%  and 60% concentrations of  lemongrass. Number SPC of bacteria in tofu soaked with 20% concentration of galangal, was significantly different with 40% and 60% concentrations of lemongrass. Number SPC of bacteria in tofu soaked with 40% concentration of galangal was significantly different with 60% concentration of preservatives lemongrass with p<0,05. Inhibition zone by 20% and 40% concentration of lemongrass was significantly different compared with inhibition zone by both 60% concentrations of turmeric and galangal toward growth of bacteria. Inhibition zone by 60% concentration of lemongrass was  significantly different compared with inhibition zone by three kinds of preservatives in 20% and 40% concentrations toward growth of bacteria. Inhibition zona by 20% concentration of tumeric was significantly different compared with inhibition zone by three kinds of preservatives in 60% concentration toward growth of bacteria. Inhibition zone by 40% concentration of tumeric was significantly different compared with inhibition zone by three kinds of preservatives in 60% concentration toward growth of bacteria. Inhibition zone by 60% concentration of tumeric was significantly different compared with inhibition zone by three kinds of preservatives in 20% and 40% concentrations toward growth of bacteria. Inhibition zone by 20% and 40% concentrations of galangal was significantly different compared with inhibition zone by three kinds of preservatives in 60% concentration toward growth of bacteria. Inhibition zone by 60% concentration of galangal was significantly different compared with inhibition zone by three kinds of preservatives in 20% and 40% concentrations toward growth of bacteria. Inhibiton zone was present in growth of bacteria caused by active substances in three kinds of natural preservatives. Coeffisient phenol test was done that show three kinds  of natural preservatives was extracted by hydrodestillation with value equal or less effective than pure phenol.   Key words : spices plants, natural preservatives, tofu, in vitro test.

  12. Manfaat Prebiotik Tepung Pisang Kepok (Musa paradisiaca formatypica terhadap Pertumbuhan Probiotik Lactobacillus casei secara In Vitro

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    Ratih Hardisari

    2016-09-01

    Full Text Available This background reviewed cases of diarrhea, one of health problems related to the digestive tract and caused by an imbalance in intestinal microflora. Probiotics are microorganisms that can be used to balance the intestinal microflora’s population. Prebiotics are nutrients required for the growth of good bacteria in human’s intestine. Kepok banana (Musa paradisiaca formatypica that contains inulin and FOS is a natural source of prebiotics. The purpose of this study is to observe the effect of various concentrations of kepok banana flour (Musa paradisiaca formatypica on the growth of probiotic bacterium Lactobacillus casei. In order to observe the prebiotic activity of Lactobacillus casei, post-test with control group design method is used toward the kepok banana flour. The amounts of kepok banana flour concentration used are varied, which are 2%, 4%, 6%, 8 %, and 10%. As much as 30 data was resulted from this research that was, later, descriptively analyzed with One-Way ANOVA test using SPSS 16.0 for Windows. The research’s finding shows the average numbers of bacterium Lactobacillus casei (the number of bacteria x 107CFU/ml produced in the media with the addition of MPF’s concentrations of 2%, 4%, 6%, 8%, and 10% are, respectively, 29187,5 ; 42491,67 ; 52225 ; 89879,17 and 155108,33. This research also obtained a significance value of 0.000 of the One-way Anova test. The conclusion of this study is that there is an in vitro effect of adding various concentrations of kepok banana flour on the growth of probiotic bacterium Lactobacillus casei.

  13. Perancangan Solar Charge Controller dan Inverter pada Aplikasi Solar Panel Berbasis Atmega8535 secara Software

    OpenAIRE

    Larasati, Devi

    2015-01-01

    The purpose of this final project is to apply the codevision AVR ATMega 8535 to process the data on the storage accumulator battery charging current from the solar panels. Value current is processed in the microcontroller is in the current detection using current sensor ACS-712. To prevent backflow from batteries to solar panels when the solar panel voltage is less than accumulator battery voltage, current flows from the solar panels through solar charge controller to the battery before. C...

  14. Penghambatan Fusarium oxysporum oleh Kultur Filtrat Bakteri Endofit dari Tanaman Kedelai secara in Vitro

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    Novi Malinda

    2016-02-01

    Full Text Available Seed borne pathogen play an important role as source of inoculum for disease incidence in the field and it becomes a major constraint in certified seed production.  Research was conducted to isolate potential endophytic bacteria from soybean plants and evaluate its culture filtrate for inhibition effect of seedborne fungi on soybean seed, i.e. Fusarium oxysporum.  The result showed that out of forty eight endophytic bacteria isolates that were nonpathogenic, there were three potential isolates that can inhibit the growth of F. oxysporum, i.e.  EDA 3, EBA 6, and EBA 7 with percent inhibition of 60.14%, 57.69%, and 57.08%, respectively. The filtrate culture of EBA 7 showed the highest inhibition (34.88% by in vitro test. Therefore, those three isolates of endophytic bacteria might be used as biocontrol agent to inhibit the growth of F. oxysporum.

  15. REGENERASI RUMPUT LAUT Kappaphycus alvarezii HASIL TRANSFORMASI GEN Sitrat Sintase MENGGUNAKAN Agrobacterium tumefaciens SECARA IN VITRO

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    Emma Suryati

    2016-02-01

    seleksi 85%, dan efisiensi regenerasi thalus non transgenik sebesar 95% pada media non selektif. Media recovery dengan penambahan pupuk PES memperlihatkan sintasan yang paling baik pada regenerasi thalus transgenik. Hasil analisis PCR memperlihatkan K. alvarezii transgenik putatif mengandung transgen PaCS di bawah kendali promoter 35S CaMV.

  16. Sistem Pendukung Keputusan Penentuan Lokasi dan Pemetaan Secara Simultan dengan OLAP

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    Harindra W Pradhana

    2016-01-01

    Full Text Available This research proposes simultaneous localization and mapping (SLAM system processed separately from the robot using data ware house. Information in the data warehouse processed separately to allow complex computation held without lowering robotic system performance. The system helps making decision by analyzing information in the data warehouse. Decision support information visualized in vector graphics to helps robotic information interpretation. This system use online analytical processing (OLAP on processing and analyzing information in the data warehouse. Visualization process use SVG to display map from robotic data processing. Web server manages all of the processing and analysis of OLAP information and displays it through browser to the user. This research produces interactive and informative decision support system. The web server quickly process information and displays it to the browser. System processing and analysis generates relevant information with low error. For further research, conventional SLAM methods can be added to the server to operate the information in the data warehouse.

  17. Pengujian secara In Vitro Oligosakarida dari Ekstrak Tepung Buah Rumbia (Metroxylon sago Rottb. sebagai Sumber Prebiotik

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    Muhammad Daud

    2009-10-01

    Full Text Available In vitro analysis of oligosaccharide from extract rumbia fruit (Metroxylon sago Rottb. as prebiotic ABSTRACT. Despite a range of commercially available oligosaccharides there is plenty of room to develop new, functionally enhanced prebiotics. current generation of oligosaccharides was not rationally developed. better understanding of factors determining the prebiotic activity of a particular oligosaccharide. Despite the range of commercially available oligosaccharides mixtures (mainly fructo and galacto-oligosaccharides, very few studies are focused on the mechanisms behind the prebiotic activity of particular oligosaccharides. Probably this lack is due to the unavailability of well characterized oligosaccharide fractions for prebiotic function assessment. The objectives of this research were to asses the ability of lactic acid bacteria in fermentation of oligosaccharide and as prebiotic (in vitro. Material used was oligosaccharide of purified rumbia fruit extract. Analysis of oligosaccharide as prebiotic was conducted in vitro using lactic acid bacteria. The lactic acid bacteria consisted Bifidobacterium bifidum, Bifidobacterium animalis, Lactobacillus bulgaricus and Lactobacillus casei Rhamnosus. The growth media for bacteria was a liquid MRS basic medium where glucose was substituted by oligosaccharide of purified rumbia fruit extract. Incubation was in aerob for Lactobacillus and anaerob for Bifidobacterium in incubator 37oC. The lactic acid bacteria was calculated 24-48 hours during incubation periode. The variables observed were: oligosaccharide component, ability of lactic acid bacteria in fermentation of oligosaccharide, and growth of lactic acid bacteria (Lactobacillus and Bifidobacterium. The result showed that the oligosaccharide component from extract rumbia fruit consisted of: sucrose, stacchiose, and raffinose. The result showed that the oligosaccharide extract rumbia fruit was significantly (P<0.05 the growth of lactic acid bacteria (Lactobacillus and Bifidobacterium and fermentation of oligosaccharide. It is concluded that oligosaccharide of rumbia fruit extract could be used as prebiotic.

  18. Analisis Dimensi Fraktal untuk Identifikasi Tanaman dengan Pendekatan Pemrosesan Citra secara Paralel

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    Mohamad Solahudin

    2010-10-01

    Full Text Available The use of camera vision and real-time computation as plant identification tool has become an active research. Application of both methods can not be separated from a pretension that the computation must produce correct results within the specified time interval where the truth of the calculation depends not only on logical truth but also on the time in which results are produced. The purpose of this study is to identify plants with fractal dimension analysis and the application of parallel computing. Fractal dimension analysis results showed that each plant has a typical Fractal dimension value. Filtration process with a small window size is accompanied by the use of multiple processors indicates that the image processing in parallel show results much faster than processing with a single processor.

  19. Penelitian penggunaan monomer n-butil akrilat untuk peningkatan mutu kulit secara iradiasi

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    Dwi Wahini Nurhajati

    1996-06-01

    Full Text Available Research on the utilization of n-butyl acrylate monomer for quality improvement leather by irradiation cobalt-60 gamma-rays is carried out as follows: Javanese crust hide was impregnated with water emulsions of n-butyl acrylate monomer for 2 hours, packed in to poly ethylene bags, sealed, then irradiated by cobalt-60 gamma rays (doses : 5 to 25 kGy. The irradiated leather was washed by water, dried and then physical tested. The results of physical test of leather modified with n-butyl acrylate showed the increasing of tensile strength and elongation, decreasing of water absorption, resistance against the flexing test of 20,000 times, and PH was constant. Organoleptic test showed that the softly of the modified leather was no different with unmodified leather.

  20. STRATEGI PENGELOLAAN SUMBER DAYA UDANG LAUT DALAM SECARA BERKELANJUTAN DI INDONESIA

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    Ali Suman

    2013-05-01

    Full Text Available Pemanfaatan sumber daya udang di Indonesia dilakukan pada wilayah perairan laut dangkal dan status pengusahaannya sudah dalam tahapan jenuh (over-fishing. Apabila kondisi ini dibiarkan dalam jangka panjang tanpa adanya usaha pengelolaan yang berkelanjutan, maka akan menyebabkan kelestarian sumber daya udang akan terancam dan bahkan bisa punah. Salah satu hal yang harus dilakukan dalam mengantisipasinya adalah mencari daerah penangkapan baru di perairan laut dalam, berupa sumber daya udang yang potensial dan belum pernah dimanfaatkan (untapped resources. Komposisi jenis udang laut dalam di perairan Indonesia lebih dari sekitar 38 jenis dengan jenis udang yang mendominasi adalah Plesiopenaeus edwardsianus dan Aristeus virilis serta alat tangkap yang disarankan untuk pemanfaatannya adalah bubu laut dalam tipe silinder. Potensi penangkapan udang laut dalam di Kawasan Barat Indonesia (KBI sebagai 640 ton per tahun dan di Kawasan Timur Indonesia (KTI sebagai 2.840 ton per tahun. Agar pengelolaan sumber daya udang laut dalam dapat dilakukan berkelanjutan, maka harus dikelola dari awal pemanfaatannya. Strategi pengelolaan yang harus dilakukan adalah membatasi upaya penangkapan pada tingkat upaya sekitar 285 armada bubu laut dalam di KBI dan sekitar 1.250 armada bubu laut dalam di KTI. Selain itu harus dilakukan penutupan musim dan daerah penangkapan serta dilakukan penetapan kuota penangkapan. The utilization of Indonesia’s shrimps resources are commonly taking from shallow marine water while its status is currently on overfishing stage. In the long run without appropriate management will threat its sutainability and may be worsen to become extinct. A possible anticipition is finding a new fishing ground at deep sea area for potential deep sea shrimps as untapped resource. Deep sea shrimps species composition have been identified for more than 38 species with mainly dominated by Plesiopenaeus edwardsianus and Aristeus virili. Recommended fihing gear for utilizing those resource is deep sea cylinder pots. Deep sea shrimps fishing potency whithin Western Indonesia Area (WIA was estimated for 640 mt/year and Eastern Indonesia Area (EIA was 2.840 mt/year. Asssuring the sustainability of deep sea shrimp resource require right and apropriate management apply since the early stage. It is proposed to adopt several management measures such as limit the fishing effort for 285 deep sea pots within WIA and 1.250 deep sea pots within EIA, apply close area and fishing season and determine total allowable catch.

  1. Pengujian Efisiensi Pasar Setengah Kuat Secara Informasi terhadap Pengumuman Inisiasi Dividen

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    Ronowati Tjandra

    2016-01-01

    Full Text Available This research explore the examination of  semistrong form-informationally efficient capital market  in Jakarta Stock Exchange towards the initiation dividend announcements. This examination focused on the effort to show the influence of initiation dividend announcement towards abnormal return at the event date and the around of that announcement and the speed of adjustment of stock price to the equilibrium price. This research using 17 firms which was identified announcing  initiation dividend 1 year after IPO (Initial Public Offering  as samples during the period 2000  until 2003 after be selected according to the conditional that stated in this research. This research was an event study that take 10 days before and 10 days after the date of announcement, so that the estimation period which be used in this examination were 21 days. The result of this research shows  that capital market of Indonesia, which represented by Jakarta Stock Exchange have already informationally- semistrong form efficient market to the initiation dividend announcement. This result was indicated by the information content in the initiation dividend announcement that  positive and significant about 6% in the event date, and surely, there was speed of adjustment from the market reaction to initiation dividend announcement that take 1 day only i.e.one day at the event date. This research also supported the agency cost model and the signaling theory, which shown by both the  high level of agency cost and informational asymmetry.       

  2. Inovasi Pelayanan Pembayaran Pajak secara Elektronik (E-billing) di Kantor Pelayanan Pajak Pratama Pekanbaru Tampan

    OpenAIRE

    Agustia, Indri; Sadad, Abdul

    2017-01-01

    Ease, speed, and accuracy in providing a service into service demands in the tax sector, as a concrete step to improve the service quality of the Tax Office Pratama Pekanbaru Charming to make an innovation service tax payment electronically or called e-Billing. However, based on field observations, researchers look at the implementation of this innovation is still a lot of taxpayers who do not understand its use because of the inability to use information technology.The purpose of this resear...

  3. PENGAMBILAN LOGAM CR6+ DAN CR TOTAL DARI LIMBAH INDUSTRI ELEKTROPLATING SECARA ELEKTROKOGULASI

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    Muhammad Nizar Pahlevi

    2012-10-01

    Full Text Available Electroplating industry is a metal coating industry by way of metal precipitate coatings on metal or plastic which is done so that the electrolytic waste containing heavy metals. Electrocoagulation is a process of merging clumps resulting from the flux of electrical current (DC for the extraction of metal compounds contained in wastewater. In this process of reduction and oxidation reactions occur. Where the metal is reduced and the positive electrode (Al will be oxidized to (Al (OH 3 which serves as a coagulant. The purpose of this research to study methods of electrocoagulation using aluminum electrodes and the influence of the length of time stirring and stirring speed of decision-CR6+ levels and total Cr. This electrocoagulation electroplating wastewater with electricity so that the ions are absorbed by the coagulant in waste binder in the release of the electrode and causes the bond between the metal ions with coagulant. Variation of stirrer speed of 200, 400 and 600 rpm, whereas the long stirring time 25, 50 and 75 minutes. Based on test results, after an analysis showed a significant reduction of the levels of total CR6 + and Cr in the electroplating wastes. CR6+ to obtain a decrease of 95.1% at minute 50 and the stirrer speed of 200 rpm, whereas the total Cr obtained a decrease of 82.69% at minute 75 and a stirrer speed of 600 rpm.

  4. Penambahan Ragi terhadap Multiplikasi Subkultur Tunas Manggis (Garcinia Mangostana L.) secara In Vitro

    OpenAIRE

    Darwati, Herlina; Wulandari, Reine Suci; Erma Safitri, Revina Rizqidia

    2013-01-01

    Garcinia mangostana L. is a species tropical forest that has many benefit. The benefitmangosteen for human life makes it worth as commodity in International market. This aimed to knowing the influence of addition some yeast concentration for bud multiplication of mangosteen and to getting the best yeast concentration for bud multiplication of mangosteen. The research took place in Sylviculture Laboratory at Tanjungpura University for 2 month. The data analyzed to usecompletely randomized desi...

  5. PERANCANGAN MODEL PENGUKURAN KINERJA LEAN DAN GREEN RANTAI PASOK SEMEN SECARA TERINTEGRASI

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    Dina Rahmayanti

    2017-06-01

    Full Text Available PT. Semen Padang is one of the reputable cement companies in Indonesia which is producing types of cement. Implementation of supply chain concept in PT. Semen Padang is very important to satisfy customers and stakeholders requirement. Performance measurement is a process to evaluate the supply chain effectiveness and efficiency in lean and green aspect. The problem is how to design performance measurement model which is integrating lean and green supply chain concepts. The objective of research is integrating lean and green supply chain concepts to design supply chain performance measurement of bag cement type. Integration of lean and green concept is designed by Balanced Scorecard (BSC perspectives that consist of financial, customer, internal process business and learning and growth. Key performance indicators (KPI are formulated and classified based on BSC perspectives. Next stage is pair wise comparison process to the weight value. Evaluation of KPI pair wise comparison based is conducted on expert opinion which is selected by consideration of their relevance knowledge and experience. The process of pair wise comparison is calculated to determine priority of the KPIs based on weight value by using Analytical Hierarchy Process (AHP method. The weight of KPI will be arrange by descending to determine the priority. Model of performance measurement is validated by face validity method. Research result is obtaining 25 KPIs that derived from integration of lean and green supply chain concept of bag cement type. Grouping is consisting of 3 KPIs of financial, 4 KPIs of customer, 11 KPI s of internal process business and 7 KPI s of learning & growth. Result is showing that customer is most prioritized element in supply chain of bag cement type. Implementation of proposing model is coordination of departments and employee in context of information accessibility.     Keywords: Supply chain, lean, green, BSC, performance measurement

  6. VALIDASI PEMERIKSAAN INFEKSI MENULAR SEKSUAL SECARA PENDEKATAN SINDROM PADA KELOMPOK WANITA BERPERILAKU RISIKO TINGGI

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    Endang R. Sedyaningsih Mamahit

    2012-09-01

    Full Text Available Accurate and adequate treatment of STIs is a critical component of STI-control activities to reduce transmission and sequelaes. On the other hand, chronic shortage in skilled staff and laboratory equipment in many countries necessitate the use of clinical skills more in order to diagnose and differentiate STIs. For these places, the WHO has recommended and produced a protocol of it syndromic approach management of STIs in place of treatment by -etiology. Since 1997 the Indonesia Ministry of Health has been conducting national training on this method. However, the syndromic approach for vaginal discharge is known to be problematic since differentiation among cervicitis, vaginitis, and even normal condition is difficult. The main objective of this study is to determine the sensitivity, specificity and positive predictive value of the syndromic approach management of women with signs and/or symptoms of abnormal vaginal discharge. The sample population were women with high risk sexual behaviors in East Java and North Sulawesi provinces. The laboratory tests using DNA hybridization probe technique (the PACE 2 test, Gen-Probe, San Diego, Calif. for Neisseria gonorrhoeae and Chlamydia trachomatis were used as gold standard. In addition, we also compared the clinical approach widely used by clinicians (mainly at hospitals with laboratory results. A total of 439 participants was recruited purposively (230 from E. Java and 209 from N.Sulawesi. In E.Java, the sensitivity, specificity, and predictive value of the syndromic management for vaginal discharge are 31%, 83%, and 59%, respectively, and in N.Sulawesi 49%, 56%, and 40%,respectively. The clinical approach did not show better results. In E.Java the sensitivity, specificity, and positive predictive value are 13%, 89%, and 50%, res­pectively, while in N.Sulawesi they are 42%, 61%, and 39%, respectively. As a conclusion, the current form of syndromic management has little use for STI screening among high risk women. Further studies by adding more criteria to the syndromes are needed to improve this method.

  7. Penetapan Kadar Fosfor Dalam Buah Petai (Parkia speciosa) Secara Spektrofotometri Sinar Tampak

    OpenAIRE

    Melisa

    2013-01-01

    Parkia speciosa generally consumed by people as other dishes, although there are some people who do not like it due to its odor. It is often recognized as a traditional and uncommon food. This plant products mineral, one of the mineral much is producted is phosphorus. The purpose of this study was to determine levels of phosphorus in the both types: petai padi and papan. Qualitative analysis of phosphorus carried out by turning it into phosphate and ammonium molybdate reagent identified,...

  8. Analisis Fosfor pada Cacing Tanah (Megascolex sp. dan Fridericia sp.) Secara Spektrofotometri Sinar Tampak

    OpenAIRE

    Safira, Cut Shafa

    2015-01-01

    Earthworm is natural resource which can be used for medication due to its highly amount of minerals. One of these minerals is phosphorus. The aim of this research are to identify, determine and know the difference content of phosphorus in Megascolex sp. and Fridericia sp. Qualitative analysis shows positive results with addition of ammonium molybdate 4% and BaCl2 5%. Quantitative analysis was done using visible spectrophotometer with ascorbic acid method, measuring blu-colored molybdenum ...

  9. RESPON EKSPLAN SETENGAH BIJI KEDELAI VARIETAS TAHAN TANAH KERING MASAM TERHADAP HIGROMISIN SECARA IN VITRO

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    D Rizania

    2016-04-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui respon dan konsentrasi optimal higromisin terhadap pertumbuhan eksplan kedelai varietas tahan tanah kering masam. Penelitian ini dilakukan dengan menggunakan Rancangan Acak Lengkap (RAL pola faktorial yang terdiri dari 2 faktor. Faktor pertama adalah varietas kedelai (var. Ijen, var. Sinabung, var. Argomulyo, var. Anjasmoro, var. Burangrang, faktor kedua adalah konsentrasi higromisin (0 mg/l, 10 mg/l, 15 mg/l, 20 mg/l, 25 mg/l. Data dianalisis dengan Anava dua jalan, bila signifikan dilanjutkan dengan uji lanjut menggunakan DMRT (Duncan’s Multiple Range Test. Hasil penelitian menunjukkan varietas kedelai dan konsentrasi higromisin berpengaruh sangat signifikan pada jumlah eksplan yang hidup, jumlah tunas, dan hari muncul tunas. Interaksi dari varietas kedelai dan konsentrasi higromisin tersebut juga berpengaruh signifikan pada semua parameter. Konsentrasi optimal higromisin yang diperlukan untuk menyeleksi eksplan kedelai varietas tahan tanah kering masam pada parameter jumlah eksplan yang hidup, jumlah tunas, dan hari muncul tunas yaitu pada konsentrasi 15 mg/l.This research aims to determine the response and optimal concentration of hygromycin on the growth of dry acid soil resintant soybean variety explant. This research was used a completely randomized design factorial consisting of two factors. The first factor was soybean variety (var. Ijen, var. Sinabung, var. Argomulyo, var. Anjasmoro, var. Burangrang, the second factor is the concentration of hygromycin (0 mg/l, 10 mg/l, 15 mg/l, 20 mg/l, 25 mg/l. Data were analyzed by using two-way ANOVA, followed by significant when using DMRT further test (Duncan's Multiple Range Test. The results showed soybean variety and concentration of hygromycin significantly effect on the number of live explants, number of shoots, and the emerging shoots. The interaction of soybean varieties and the hygromycin concentration was also a significant effect on all parameters. Optimal concentration of hygromycin required for selection of dry acid soil resistant soybean variety explant on the parameter number living explants, number of shoots, and the emerging shoots was 15 mg/l.

  10. PENGOLAHAN LIMBAH CAIR ORGANIK SECARA BIOLOGI MENGGUNAKAN REAKTOR ANAEROBIK LEKAT DIAM

    OpenAIRE

    Indriyati, Indriyati

    2018-01-01

       Organic waste water can be treated biolocally by using anaerobic fixed bed reactor. Fixed bed reactor is bioreactor which is compleeted with support material inside reactor for bacteria fixation in the surface area of support material. The benefit of using this kind of technology are it needs low energy, low nutrien, low sludge production and could treat high organic concentraion waste water.   The support material  has important role in the  Fixed Bed reactor performance, therefore it mus...

  11. HUBUNGAN SENSISTIVITAS PLASMODIUM FALCIPARUM TERHADAP KOMBINASI PIRIMETAMIN/SULFADOKSIN DAN KLOROKUIN SECARA IN VITRO

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    Sahat Ompusunggu

    2012-09-01

    Full Text Available An in vitro sensitivity test was conducted to study the sensitivity of Plasmodium falciparum against chloroquine and pyrimethamine/sulphadoxine combination. The relationship between sensitivity of the parasite to the two drugs was also studied. A total of 72 patients from five localities were examined during 1984-1985. Test against chloroquine was conduc­ted according to WHO method, while against pyrimethamine/sulphadoxine combination, a modified method of Nguyen Dinh and Payne and Eastham and Rieckmann was used. The results showed that there is no relationship between the sensitivity of P. falciparum against pyrimethamine/ sulphadoxine combination and chloroquine. It can be concluded that in case of chloroquine resistant P. falciparum, pyrimethamine/sulphadoxine combination could be applied as an alternative chemotherapy.

  12. Penetapan Kadar Kalsium, Kalium, Dan Natrium Pada Kangkung (Ipomoea Aquatica Forssk.) Secara Spektrofotometri Serapan Atom

    OpenAIRE

    Hasibuan, Anggita Vela

    2016-01-01

    Kangkung is one of the vegetables that are quite popular in public and this plant include in the tribe of convolvulaceae. This plant contains many important elements that needed by the body, that are carbohydrate, protein, fat, vitamins, and mineral such as calcium, potassium, phosphorus, iron, and sodium. The purpose of this research was to determine the level of calcium, potassium, and sodium in land kangkung and water kangkung. Methods of research conducted by dried destruction to the...

  13. Pembuatan minyak kelapa secara enzimatis dengan memanfaatkan kulit buah dan biji pepaya serta analisis sifat fisikokimianya

    OpenAIRE

    Yunita Susanti; Purwanto Purwanto; Yuliana Kristiani Dewi

    2012-01-01

    Enzymatic process using papain is an efficient and less expensive method for producing coconut oil. This research was conductedto produce coconut oil which meet quality requirement from Cocos Nucifera L using ripe fruit peel and seed of papaya (Carica PapayaL) as enzyme sources. The coconut oil was prepared by mixing of coconut milk and juice of papaya ripe fruit peel and/or seed; and thenthe oils produced and incubated for 24 hours. The physicochemical properties of the coconut oil were dete...

  14. Implementasi Kebijakan Layanan Secara Elektronik Pengadaan Kendaraan Dinas Pemerintah Provinsi Jawa Barat

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    Yusa Djuyandi

    2013-10-01

    Full Text Available Electronic Procurement Service (LPSE is a policy in the procurement of goods and services with internet-based, which facilitates a transparent auction. West Java was chosen as one of the 5 LPSE Center and expected to create transparency and accountability in government management. The purpose of this study is to describe and analyze the LPSE policy implementation, particularly in the procurement of official vehicles in West Java Provincial Government. The research was conducted through observation and interview techniques. Data consisted of primary and secondary data, therefore this research design used qualitative methods. The theory used in this study was the theory of policy implementation. Based on the research, it is known that the policy implementation of LPSE, particularly in the procurement of official vehicles in West Java Provincial Government, is not only able to minimize the corruption potential, but also able to provide a positive impact on the financial condition of local governments. This research conclusion is LPSE policy implementation running well. 

  15. Efektivitas Pengadaan Barang dan Jasa secara Elektronik (E-procurement) pada Lpse Kota Pekanbaru

    OpenAIRE

    Swadesi, Utari; Sadad, Abdul

    2017-01-01

    This research is based on the phenomenon is still often the occurrence of corruption, collusion and nepotism (KKN) practices of goods and services by the government. So that e-procurement can be an instrument to prevent and reduce corruption, collusion and nepotism (KKN) because through e-procurement program, procurement of goods and services can further improve transparency and accountability, increase market access and fair business competition, Improve the efficiency of the procurement pro...

  16. ANALISA PEMROSESAN DATA SECARA ONLINE ( ONLINE ANALYTICAL PROCESSING / OLAP UNTUK DUNIA PENDIDIKAN

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    Budi Santosa

    2015-04-01

    Full Text Available The development of database technology is currently very rapidly , many forms have only used as data storage technology that consists of fields , and the record is processed and displayed a variety of display formats of information in a simple , but now stems from the simple form have obtained a method for displaying a database useful to analyze the data for a particular purpose . By utilizing existing relational database then obtained a way to anticipate the need to analyze data quickly to help get a decision in an organization Methodology that will be used in this study include ; Literature and SDLC ( System Development Life Cycle which includes the step of Analysis , Design , Implementation , Testing and Maintenance . Software used to build this application is SQL Server 2012 . The results of this study are business intelligence applications with OLAP concepts for education ( case study in Informatics Engineering Department UPN " Veteran " Yogyakarta that can help to get information quickly and accurately in analyzing student data and analysis that analyzes ipk credits .

  17. Daya Antibakteri dan Waktu Kontak Infusa Teh Hijau (Camellia sinensis Terhadap Salmonella typhi Secara In Vitro

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    Dione Margareth Setiawan

    2010-06-01

    Full Text Available Green tea (Camellia sinensis contains cathecin which has been reported to have various pharmacologic properties, such as an antibacterial agent. Salmonella typhi, as agent of typhoid fever, remains a public health problem in tropical countries; about 20 million cases and 600.000 deaths annually all over the world. Objectives of this research were to observe the antibacterial activities and contact time of green tea infusion againsts Salmonella typhi by in vitro experiment. The experiment took place in Microbiology Laboratory, School of Medicine, Padjadjaran University, Bandung, March-April 2009. Methods: In vitro laboratory analytic study has been conducted on green tea infusion of Indonesian and Japanese commercial package againsts Salmonella typhi. The study used agar well diffusion method and analyzed by ANAVA and t-independent test. Results: Only at concentration of 40% (w/v, Indonesian green tea infusion gave an average inhibition area of 3.376±0.334 mm diameter, and 3.571±0.217 mm on Japanese package, while below 40% were 0.707±0.000 mm with no differences between both packages (p>0.551. There has been observed any turbidity in all Muller Hinton liquid media on both packages compared with control medium, also any growth of Salmonella typhi collony in all Muller Hinton agar at concentrations below 40%. Green tea infussion on both packages has been observed to have antibacterial activities at 40% but neither been observed at concentration below 40%.

  18. Pengaruh Pretreatment Secara Alkalisasi-Resistive Heating terhadap Kandungan Lignoselulosa Jerami Padi

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    Dewi Maya Maharani

    2017-09-01

    Full Text Available Cellulose is a potential biomass that is used for bioethanol production and commonly present in agricultural residues like rice straw. Cellulose is an important material to produce glucose and bioethanol, but it is covered by lignin and hemicellulose bonds to form a lignocellulose.  Bioethanol production using basic material containing cellulose requires special attention in the process of pretreatment for lignin degradation process and increase the accessible surface and decrystallize cellulose. The aim of this research was to apply alkalization and resistive heating combine method for rice straw pretreatment process before further being converted into bioethanol and to determine the effects of heating temperature and NaOH concentration on the content of  lignin, cellulose, and hemicellulose. The reactor had been designed for resistive heating process. Rice straw that was resized into 100 mesh has dissolved with 0.03 M, 0.05 M, and 0.07 M NaOH and heated with resistive heating temperature of 75 oC, 85 oC, and 99 oC. Cellulose is a raw material that will be further converted into glucose. So that, the selected optimum conditions of this study were  pretreatment with the highest increase of cellulose content level until 8.88% and resulted decreasing levels of lignin (1.39% and hemicellulose (4.33% by temperature  75 oC and 0.07 M NaOH concentration. Resistive heating that combine with alkalization can be used for rice straw pretreatment process that reduce lignin and hemicellulose content as well as increasing cellulose content.   ABSTRAK Selulosa merupakan biomassa yang potensial digunakan untuk produksi bioetanol dan banyak ditemukan di residu pertanian seperti jerami padi. Selulosa merupakan material penting yang dapat dikonversi menjadi glukosa kemudian dikonversi menjadi bioetanol, namun selulosa pada alam dilapisi oleh ikatan lignin dan hemiselulosa menjadi lignoselulosa. Pembuatan bioetanol berbasis selulosa membutuhkan proses pretreatment yang berfungsi untuk mendegradasi ikatan lignin, meningkatkan luas permukaan biomassa dan dekristalisasi selulosa. Tujuan dari penelitian ini adalah mengetahui pengaruh alkalisasi resistive heating pada proses pretreatment jerami padi sebelum dikonversi lebih lanjut menjadi bioetanol dan mengetahui pengaruh suhu pemanasan serta konsentrasi NaOH selama pretreatment terhadap perubahan kandungan lignin, selulosa dan hemiselulosa. Sebelum dilakukan penelitian dilakukan perancangan reaktor resistive heating. Jerami padi ukuran 100 mesh dilarutkan pada larutan NaOH dengan variasi konsentrasi 0,03 M, 0,05 M, dan 0,07 M, selanjutnya dipanaskan pada reaktor resistive heating dengan variasi suhu pemanasan 75 oC, 85 oC, dan 99 oC. Selulosa merupakan senyawa yang akan dikonversi lebih lanjut menjadi glukosa. Sehingga pada penelitian ini dipilih kondisi optimum berdasarkan peningkatan selulosa tertinggi hingga 8,88% serta penurunan lignin dan hemiselulosa sebesar 1,39% dan 4,33% pada perlakuan suhu pemanasan 75 oC dan konsentrasi NaOH 0,07 M. Alkalisasi resistive heating dapat diterapkan pada pretreatment jerami padi karena dapat mengurangi kandungan lignin dan hemiselulosa serta meningkatkan kandungan selulosa.

  19. Model Stimulus-Organism-Response: Penentu Perilaku Pembelian Konsumen Secara Situasional

    OpenAIRE

    Magdalena, Nonie

    2005-01-01

    Understanding about consumer purchase behavior is an essential aspect for developing organization bussiness strategic, especially in retailing. S-O-R (Stimulus-Organism-Response) model helps the practision and academics to understand which stimulus will influence consumers and the reaction that comsumer gave. One of the stimulus that explained in this article is the situation. Situation is an aspect that had change and hardly to predict. In other words, situation will determine consumer purch...

  20. Pengembangan The Two-Tier Diagnostic Tes pada Bidang Biologi secara Terkomputersisasi

    Directory of Open Access Journals (Sweden)

    Suwarto Suwarto

    2013-01-01

    Full Text Available Abstrak Penelitian bertujuan mengembangkan tes diagnostik dua tingkat (the two-tier diagnostic test pada bidang biologi dan mengembangkan program komputer untuk mendiagnosis kesulitan belajar siswa. Tes disusun melalui tiga fase, yaitu (1 defining the content boundaries; (2 identifying students’ misconceptions; dan (3 developing instrument. Pengembangan program komputer terkait dengan soal, siswa, tabel kerja, SQL (Structured Query Language, ketuntasan, dan grade. Tes diagnostik yang dikembangkan ada 3, yaitu tes A, tes B, dan tes C. Responden untuk tes A dan tes B ada 130 siswa dan untuk tes C ada 128 siswa. Analisis statistik dilakukan dengan program iteman versi 3,00. Program komputer yang dikembangkan diujicobakan di SMAN 1 Tawangsari dan SMA Veteran 1 Sukoharjo. Hasil penelitian adalah Tes A terdiri atas 73 butir, dengan rentang kesulitan butir 0,031-0,962, rentang daya beda butir 0,013-1,000 dan reliabilitas 0,871; Tes B terdiri atas 39 butir, dengan rentang kesulitan butir 0,038-0,762, rentang daya beda butir 0,009-0,918 dan reliabilitas 0,768; dan Tes C terdiri atas 79 butir, dengan rentang kesulitan butir 0,102-0,938, daya beda butir 0,029-1,000 dan reliabilitas 0,894. Program komputer untuk mendiagnosis kesulitan belajar telah berfungsi dengan baik. Kata kunci: tes terkomputerisasi

  1. SISTEM INFORMASI SECARA ONLINE TUGAS AKHIR MAHASISWA JURUSAN TEKNOLOGI INFORMASI FAKULTAS TEKNOLOGI INFORMASI DAN KOMUNIKASI

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    Atmoko Nugroho

    2015-08-01

    Full Text Available Tugas Akhir is the last stage that will surely passed by students to earn college scholarship. And one of the activities in the field of data administration is to manage file of Tugas Akhir, especially for the submission title and Coordinators of Tugas Akhir. Coordinators are often difficult to check the title of Tugas Akhir, if it has been filed or is pending, and the difficulties in monitoring the load guidance from their Supervisor of Tugas Akhir. This also forms the basis for making an Information System of Tugas Akhir (Sistem Informasi Tugas Akhir with the aim of assisting Jurusan Teknologi Informasi and students take this. Sistem Informasi Tugas Akhir called SITA also be made online this method applying Prototype system development. Prototype method according to Pressman has experienced several stages, namely: collection needs (listen to customers, design (built / REVISE mock-up and evaluation of prototypes (customer test-drives a mock-up. The collection needs to be done, among others, the acquisition of data. The data used in this information system is the data of Tugas Akhir of Jurusan Teknologi Informasi. The next stage in the design, researchers uses planning tool in the form of Unified Modeling Language system (UML and developed using the PHP programming language. System of web-based information created a purpose to be accessible without being restricted by time and place, whereas the benefit derived is facilitated student and coordinator duties in management of Tugas Akhir.

  2. Kandungan Xantofil Daun Lamtoro (Leucaena leucocephala Hasil Detoksikasi Mimosin Secara Fisik dan Kimia

    Directory of Open Access Journals (Sweden)

    E. B. Laconi

    2010-04-01

    Full Text Available Leucaena (Leucena leucocephala is a feed source which has high protein and carotenoid, but its utilization as feed was limited by the presence of mimosine (β-N-(3-Hydroxy-4 pyridone-α amino propenoic acid as a toxin. Experiment was carried out using completely randomized design with 4 detoxification treatments and 5 replications. Detoxification treatments of leucaena leaf consisted of (1 non treated leucaena leaf, (2 steamed heating at 70 oC for 15 minutes, (3 dry heating at 70 oC for 12 h, (4 soaking with fresh water for 12 h, (5 spray with NaOH 5%, incubated for 12 h. Variables measured were mimosine and xanthophylls contents. Data were analyzed using analysis of variance and duncan multiple range test was further done to test the significant differences between means. The results showed that soaking leucaena leaf with fresh water for 12 h gave the highest reduction for both mimosine and xanthophylls contents and steamed heating at 70oC for 15 minutes had the highest xanthophylls content post detoxification. It was concluded that steamed heating at 70oC for 15 minutes was the best detoxification methods for mimosine in leucaena leaf.

  3. Pengolahan Sampah Secara Pirolisis dengan Variasi Rasio Komposisi Sampah dan Jenis Plastik

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    Qonita Rachmawati

    2015-03-01

    Full Text Available Pada tahun 2012, sampah yang dihasilkan sebesar 1200 ton/hari. Jika permasalahan sampah di Kota Surabaya tidak ditangani dengan baik maka akan menimbulkan beberapa masalah antara lain: masalah kesehatan dan masalah kebersihan. Oleh karena itu, diperlukan metode yang dapat mengolah sampah namun tidak menimbulkan masalah baru lainnya. Salah satu metode pengolahan sampah yang telah dikembangkan, yaitu metode pirolisis. Penelitian ini bertujuan untuk menentukan pengaruh jenis plastik dan komposisi terhadap produk hasil pirolisis. Pada penelitian ini digunakan reaktor dengan kapasitas 500 g yang berbahan stainless steel. Variabel yang digunakan yaitu jenis sampah plastik dan komposisi sampah. Jenis sampah yang digunakan yaitu sampah plastik HDPE (High Density Polyethylene, PET (Poly Ethylene Terephthalate, dan PS (Poly Styrene. Komposisi sampah yang digunakan antara lain: 100:0, 75:25, dan 50:50. Temperatur yang digunakan pada reaktor yaitu 500°C dengan waktu 30 menit. Penelitian dimulai dari persiapan bahan uji, persiapan reaktor, percobaan pendahuluan, dan penelitian dengan reaktor pirolisis. Selanjutnya dilakukan analisis untuk masing-masing hasil produk. Penelitian ini jenis sampah plastik yang menghasilkan gas tertinggi yaitu jenis plastik PET sebesar 45,40% dan jenis plastik yang menghasilkan wax tertinggi yaitu jenis plastik HDPE sebesar 69,91%. Sedangkan komposisi yang menghasilkan gas tertinggi yaitu komposisi dengan ranting 25% dan PET 75% sebesar 71,24% dan komposisi yang menghasilkan wax tertinggi yaitu komposisi dengan ranting 25% dan PS 75% sebesar 61,36%.

  4. Al-‘Azl (Senggama Terputus dalam Perspektif Hadis (Disyarah Secara Tahlili

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    Sulaemang L

    2015-11-01

    ibu. Implikasi penelit ian ini adalah; (1 Untuk mengetahui hadis-hadis Nabi saw. sebagai dasar melakukan al-‘Azl pasangan suami istri; (2 Untuk menghilangkan keraguan tentang hadis-hadis al-‘Azl apakah dibolehkan melakukannya atau dilarang; (3 Untuk memahami kandungan hukum hadis tentang al-‘Azl; (4 Untuk mengetahui bahwa dari seluruh alat KB yang digunakan, yang paling aman dari segi kesehatan, dan hukum Islam adalah melakukan al-‘Azl.             Kata Kunci : pengaturan kelahiran, Al-‘Azl, senggama terputus

  5. Model EPQ Multi Item yang Dimodifikasi untuk Dua Permintaan secara Simultan

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    Taufiq Rahman

    2017-05-01

    Full Text Available Inventory is one of many factors of the business operation that need to be controlled by industries in order to improve efficiency, enhance productivity, and decrease the holding cost. The holding cost of inventories in supply chain contribute to 20% - 40% of the product value. It can be controlled by applying appropriate inventory model, such as EPQ/Economic Production Quantity and EOQ/Economic Order Quantity. EPQ is an inventory model that used to determine the optimum production lot size with balanced the production setup cost and holding cost. Even the classic EPQ has applied widely in industries, the assumption used by this model differed between the researchers whether it is continuous or discrete demand, because the multi delivery or discrete demand is mostly used by industries. Even so, there are industries that used both continuous and discrete demand simultaneously. Based on previous research, there was an advanced EPQ model that synchronizing both assumptions simultaneously, but it still addressed single item problem. Since almost the industries produced multi item, this model has lack of applicability. Therefore, this research proposed a multi item EPQ Model that synchronizing continuous and discrete demand simultaneously. The solution procedure that used in this proposed model are classical calculus method/differential calculus and simultaneous approach. A numerical example is given to show the effectiveness of the proposed approach based on the data from the literature.

  6. Sistem Pendeteksian Keserasian Warna Kulit dan Busana Secara Otomatis Untuk Jenis Kelamin Perempuan Berbasis Image Processing

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    Meza Silvana

    2014-03-01

    Full Text Available Compatibility of the clothes become a necessity that can not be avoided by everyone, because accuracy in choosing the color of the clothes will be very supportive of woman's appearance. So far, the research has been done only discuss about skin type or the grouping of clothing only, and compatibility of clothing color is also done manually estimates that are relative. Therefore, this study was designed to make a priority fashion color for each type of skin color automatically based on skin color flexibility. The system will determine the priority of the right clothing colors for certain skin types based on a combination of several colors clothes. The testing process is done for each color of clothing to see how far each level according to the fashion color of the skin color. From the results, six (6 elected fashion color with skin color, and the color matching chart rate on the test results chart system has approached the sample data in the database system.

  7. PELATIHAN MANAJEMEN PEMELIHARAAN ITIK SECARA INTENSIF DI KECAMATAN WEDUNG KABUPATEN DEMAK

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    Priyantini Widiyaningrum

    2014-02-01

    Full Text Available The training of intensive breeding management has been carried out for duck farmers at district Wedung - Demak, on July-August 2013. The training was conducted in three activities, namely: (a the transfer of knowledge about technique of preparing duck feed by available material, intensive maintenance , and incubator hatching technique; (b implementation of intensive maintenance for the fertile eggs product, and (c the practice of using the hatching incubator. Participants were duck farmer at Mutih Kulon and Tedunan, that maintain their ducks with extensive (grazing method. The results showed that the 27 participants who took the training have never been participated in the training of duck management. The reason of farmer breeding with grazing method, because they follow the habits of their parents. Most participants know that the maintenance of grazing method is bad, and they know that the intensive maintenance will increase the profits. The Proximate analysis of ration duck showed that its composition has taught balanced feed criteria. Production of eggs in the intensive maintenance hatchability reached 92%, eventhough the experiment at the farmer level reached 70.5% only.

  8. Hubungan Lama Menderita DM dengan Perilaku Perawatan Kaki secara Mandiri untuk Mencegah Ulkus Diabetikum

    OpenAIRE

    Apriliyasari, Renny Wulan

    2015-01-01

    Diabetes Mellitus (DM) atau yang biasa disebut kencing manis merupakan suatu kelompok penyakit metabolik dengan karakteristik gula darah melebihi nilai normal. Data dari Dinas Kesehatan Kabupaten Pati jumlah penderita DM meningkat, dengan rata-rata pada 2 tahun 2008-2009 sebanyak 1950 orang. Hasil survey di RSUD RAA Soewondo Pati, penyakit diabetes mellitus menempati peringkat pertama penyakit rawat jalan 2013 dengan 3893 total kunjungan atau sebesar 4,83%. Salah satu hal penting pada pasien ...

  9. Penggunaan Kromium Organik dari Beberapa Jenis Fungi terhadap Aktivitas Fermentasi Rumen Secara in Vitro

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    W.D. Astuti

    2006-12-01

    Full Text Available Chromium appears to be an essential trace element since 1959, but its effect on ruminal microbes is not clear yet. This experiment was conducted to study the effects of organic chromium supplementation on rumen fermentation activity. An in vitro technique was held using randomized block design with 13 treatments and 3 replications. There were four kinds of organic Cr used, produced with four different species of fungi as carriers. Fungi used as carriers were Saccharomyces cerevisiae, Aspergillus oryzae, Rhizophus oryzae and “ragi tape”. The result indicated that the optimum organic Cr supplementation was 1 mg organic Cr/kg dry matter. Supplementation of 1 mg organic Cr/kg dry matter increased dry matter and organic matter digestibilities. It also tended to increase NH3 and total VFA production. Propionate production increased, which decreased methane production and increased hexose conversion efficiency in several treatments. Each fungus used as carrier of organic Cr resulted in different effects on rumen fermentation activity, but the effects was within a normal range. It was concluded that either Saccharomyces cerevisiae, Aspergillus oryzae, Rhizophus oryzae or “ragi tape” could be used as carrier in organic Cr production.

  10. KUANTITAS ANAKAN KULTUR SEMUT RANGRANG, Oecophylla smaragdina, SECARA ARTIFISIAL DENGAN MENGGUNAKAN BEBERAPA JENIS PAKAN BERBEDA

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    Lintang Dianing Ratri

    2017-03-01

    Full Text Available Oecophylla smaragdina or weaver ants is social insect that has an important role in the ecosystem. One of its main function is as a biological control agent in agriculture. The use of weaver ants in an effort to develop a biocontrol continues and increases, this has caused the significant decrease of the natural population of O. smaragdina. Therefore, the weaver ants rearing is needed to maintain its existence in natural habitat without excessive exploitation. The purpose of this study were to determine the effect of different types of feed i.e. snails, earthworms, and okara (tofu by-product in the production of weaver ants kroto; and to determine the different of treatments of feeds provided to the production quantity of weaver ants kroto. The experimental method used in this study with a completely randomized design. Treatment was given by different protein sources feeding i.e. snails (Pomacea canaliculata, earthworm (Lumbricus rubellus, and okara. Five replicates were appliead for each treatment. Earthworms fed ants produced highest number of kroto with total of 1,030 individuals and weight 87.4 gram in total. Snails fed ants produced 866 individuals and weight 73.1 gram. Okara fed ants produced 543 individuals and weight 45.9 gram.

  11. Penelitian penggunaan monomer n-butil akrilat untuk peningkatan mutu kulit secara iradiasi

    OpenAIRE

    Dwi Wahini Nurhajati; Suliestiyah Wiryodiningrat; Kadarijah Kadarijah; Penny Setyowati

    1996-01-01

    Research on the utilization of n-butyl acrylate monomer for quality improvement leather by irradiation cobalt-60 gamma-rays is carried out as follows: Javanese crust hide was impregnated with water emulsions of n-butyl acrylate monomer for 2 hours, packed in to poly ethylene bags, sealed, then irradiated by cobalt-60 gamma rays (doses : 5 to 25 kGy). The irradiated leather was washed by water, dried and then physical tested. The results of physical test of leather modified with n-butyl acryl...

  12. pemeliharaan yuwana abalon (Haliotis squamata TURUNAN F-1 SECARA TERKONTROL DENGAN JENIS pakan BERBEDA

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    Bambang Susanto

    2016-11-01

    Full Text Available Abalon (Haliotis squamata merupakan jenis kekerangan yang mulai dikembangkan untuk dapat memenuhi permintaan pasar. Tingkat pertumbuhan abalon sangat lambat sehingga perlu dilakukan penelitian untuk memacu pertumbuhan. Tujuan penelitian ini adalah untuk mengetahui jenis pakan yang cocok dan dapat memacu pertumbuhan yuwana abalon. Biota uji yang digunakan adalah yuwana abalon dengan ukuran panjang cangkang awal 12,51 ± 1,27 mm, yang ditempatkan dalam wadah plastik berukuran 35 cm x 25 cm x13 cm, diisi dengan kepadatan 25 ekor/wadah. Perlakuan jenis pakan berbeda adalah (A pelet, (B pakan rumput laut (Gracilaria spp., dan (C kombinasi rumput laut dan pelet. Hasil penelitian menunjukkan bahwa pemberian jenis pakan berbeda memberikan pengaruh yang nyata (P<0,05 terhadap tingkat pertumbuhan panjang, lebar cangkang, dan bobot badan yuwana abalon turunan F-1. Abalone (Haliotis squamata is one of shellfish to develop for market demand. The growth of abalone is slow and this experiment was purposed to increase to find out the suitable kinds of feed to promote the growth of abalone juvenile in hatchery. The rearing of abalone juvenile was conducted in plastic boxes size of 35 cm x 25 cm x 13 cm, filled with density of 25 ind./box with initial shell length of 12.51 ± 1.27 mm. The experiment applied different kinds of feed, (A pellet, (B seaweed/Gracilaria spp., and (C combination of seaweed and pellet with three replicates in each treatment. The result of the experiment indicated that different feeding resulted in significant difference (P<0.05 on growth of width and length of shell and body weight abalone juvenile F-1 generation.

  13. ANALISIS KUALITATIF KANDUNGAN KIMIA KALUS Sonchus arvensis L. HASIL PERTUMBUHAN SECARA KULTUR JARINGAN

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    Katno Katno

    2012-10-01

    Full Text Available Plant tissue culture tecnique can be used to produce chemical compound or secondary metabolites from medicinal plant. The chemical compound of medicinal plants sometime produced locally within the callus. These compounds are generally identical with the one produced by medicinal plantgrowth in the field. Sonchus arvensis (tempuyung used as diuretic and anti-kidney stone. The flavonoid compound of Sonchus arvensis related to such activities are Apigenin 7-glucoside and Luteolin 7-glucoside. The both compounds of Sonchus arvensis are active as anti-kidney stone and diuretic by plant tissue  culture. The reseach was carried out in plants tisue culture laboratory at BPTO Tawangmangu from June to Jully 2002. The callus of Sonchus arvensis  aged of 50 days was analized with spot test and TLC methode. The result was compared to the chemical compounds from Sonchus arvensis which growth in the field. The result showed that chemical compound from  the callus and the plant growth in the field were identical.

  14. Analisis dan Perancangan Website Pembelajaran Bahasa Secara Mandiri di Self Access Language Learning Center Bina Nusantara

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    Hady Pranoto

    2010-12-01

    Full Text Available The purpose of this research is to build an independent language learning applications using Internet technologies to facilitate the user in learning the language. The research method used is by analyzing the ongoing learning process; analyze the constraints and limitations of existing facilities and designing new processes to address existing constraints and limitations. In designing a language self learning website authors examine the existing through observation, interviews and questionnaires to the stakeholders who use the system. Observations also observed duration of the user in conducting learning activities, and provided space to accommodate the transaction. After analysis of the current system, author designing the new system using object-oriented design methods and using analysis tools UML. After completed the system design done system built using ASP.NET programming language. The Conclusions is an independent language learning applications using Internet technology giving easy way to facilitate the learning process in terms of accesing time and place, and the application also provide facilities for teacher to monitoring student self learning. 

  15. Pemodelan dan Prediksi Daya Ouput Photovoltaic secara Real Time Berbasis Mikrokontroler

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    Eka Prasetyono

    2015-09-01

    Full Text Available The electrical energy generated by the photovoltaic (PV as a renewable energy source highly affected by environmental conditions such as intensity of sunlight irradiance, temperature, geographic location and tilt angle of PV itself. How much power should be generated by the PV for every times and anywhere will be discussed in this paper. This paper are implemented models of clear sky solar irradiance, solar position and PV temperature to predict the power output should be generated by PV. The model is implemented on the ARM Cortex M4F microcontroller STM32F407 which is a 32bit microcontroller and equipped with DSP, so the prediction of PV power output can be done online and in real time. To be able to predict the PV power output online, at any time and wherever they are, in this study microcontroller equipped with temperature sensors and input geographical information (latitude-longitude and also equipped with a memory card for data logger between the predictions and field measurement. Results have been obtained by field experiments, measurements test for PV is very close to predictions with an average error 4.72% and computation time for all models by microcontroller with DSP instruction 33.64% faster compare to without DSP instruction.

  16. RESEPSI KESADARAN BERBAHASA SECARA KRITIS DALAM AKTIVITAS PENULISAN FIKSI GURU DAN SISWA

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    Suminto Sayuti

    2013-01-01

    Full Text Available This study aims to describe the reception of critical language awareness (CLA in the fiction writing process among senior high school (SHS teachers and students. It was a content analysis supported by qualitative data collected through focus group discussions. The subjects were SHS teachers and students in Yogyakarta Special Territory. The data analysis in the process of interpreting meanings of their works was based on the CLA elements. The findings showed that their reception of CLA in fiction writing was reflected in both the process and the outcome. The teachers were still not optimal enough in developing methods, using media, and selecting the assessment system in the learning of fiction writing. Most of the students’ works did not reveal the awareness of the importance of language power and self-position as writers.

  17. Efeito imediato e mediato da acupuntura no tratamento de pacientes portadores da Síndrome de Apnéia Obstrutiva do Sono

    OpenAIRE

    Sugai, Gisele Cristina Machado [UNIFESP

    2009-01-01

    STUDY OBJECTIVES: 1 - To investigate the immediate (single session) and mediate (ten sessions) effect of acupuncture over the sleep pattern of patients with moderate obstructive sleep hypopnea apnea (OSHA). 2 - To compare manual acupuncture (MA) and electroacupuncture (EA) with different stimulation frequencies (2 Hz and 10 Hz). 3 - To determine the role of endogenous serotonin in this mechanism. SETTING: Department of Physiology, Sleep Division of Department of Psychobiology, Chinese Medicin...

  18. MODEL PENYELESAIAN SECARA ALTERNATIF DALAM PERADILAN PIDANA (STUDI KHUSUS TERHADAP MODEL PENYELESAIAN PERKARA PIDANA OLEH LEMBAGA KEPOLISIAN

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    Sudaryono Sudaryono

    2015-07-01

    Full Text Available The problem statements of this study include: 1 what are the types of criminal cases handled by the police; 2 how do the police handle the cases; and 3; how do the police’s insight of handling them alternatively. In the first year, the study aims to 1 establish the types of criminal cases handled by the police; 2 inventory the ways the police handle them; and (3 describe the police’s insight of a model for handling those alternatively. Hopefully, it can be beneficial for academicians and policy makers. For the academicians, it can be meaningful to contribute to criminal law development, particularly an alternative model for handling criminal cases. For the policy makers, it can be useful to develop a conceptual thinking to make a policy of handling criminal cases oriented to substantive justice.The study is a research of sociological law with qualitative approach. For this, the data included primary and secondary. The data employed a content analysis with legal and theoretical interpretations.Reserch product: In running its juridical responsibility, from January to May, 2011 the Polresta Surakarta has handled a variety of criminal cases. The types of these cases handled by the Polresta in 2011, particularly for five months, consisted of 33 cases. Out of the 2 felony cases were conventional at 25 criminal cases and unconventional (transnational at 8 criminal cases. In handling the criminal cases, the Polresta Surakarta uses a fixed procedure as a reference to them, as stipulated in the Act of the Criminal Code, operating rule and guidance and technique of the Indonesian Police Administration. In facing the implication of the ADR to handle criminal cases, the Police have actually taken a better action. In the Telegram of the Criminal Investigation Bureau (STR, the Sub-Division of the STR of the Indonesian Police No ST/110/V/2011, dated on May 18, 2001 on the Implication Guidance of the ADR in the Rank of the STR of the Indonesian Police, the STR of the Indonesia Police will apply the ADR to handle criminal cases. Unfortunately, the policy is delayed with the Telegram of the STR of the Indonesian Police No ST/209/IX/2011, dated September 6, 2001 on Delaying the Implication of the ADR in the Rank of the STR of the Indonesian Police.

  19. PENGARUH EKSPLAN DAN ZPT TERHADAP PERTUMBUHAN nEPEnTHES ALBOmARGInATA SECARA In VITRO

    OpenAIRE

    Sukamto, Lazarus Agus

    2016-01-01

    Nepenthes albomarginata Lobb ex Lindl. is a carnivorous plant, distributes in several regions in Indonesia. The plant population decreases drastically because of over exploitation and ruining nature habitat. Plant propagation by nature and cutting are not enough to rehabilitation its population. In vitro culture of N. albomarginata was carried out using plantlets grown from the seeds in vitro. Plantlets were cut to became two part explants, consisted of shoot tip and under-shoot tip cuttings....

  20. PENEKANAN PERKEMBANGAN PENYAKIT BUSUK BATANG VANILI (FUSARIUM OXYSPORUM F.SP. VANILLAE MELALUI SELEKSI ASAM FUSARAT SECARA IN VITRO

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    Endang Nurcahyani

    2013-09-01

    fungus has been initiated by in vitro selection on medium containing fusaric acid. The aims of this research were: (1 to investigate effective concentration of fusaric acid used for in vitro selection, (2 to characterize mutants which have been set up and also to test those mutants for their resistance to the fungus. The results showed that: (1 fusaric acid at the concentration of 110 ppm effectively suppressed the disease intensity up to 25% compared to the concentration of 90 ppm and 100 ppm. In other words, 110 ppm of fusaric acid has increased the category criterion from moderate to resistant, (2 there was an increase of the total phenol content and thickness of lignin in vanilla stem, and (3 the protein profile of vanilla plantlet was different from the control. There was an initiation of a new band of about 18 kD in a mutant predicted as a protein which is responsible for vanilla resistance to Fusarium.

  1. Analisa Kadar Kalsium Oksida (CaO) Pada Berbagai Jenis Pakan Ayam Secara Titrasi Permanganometri Di Baristand Industri Medan

    OpenAIRE

    Tarigan, M. Rosidi

    2010-01-01

    Livestock woof is food for the livestock of chicken owning complete content nutrisi. mineral calcium is one of very content nutrisi in need of chicken livestock if insuffiency will cause the mineral deficiencies at the chicken livestock.livestock woof can be differentiated according to used type is adapter for type of livestock and livestock age,every the livestock woof contain the nutrisi which different each other. To adjust the need of nutrisi of chicken livestock hence doing content ...

  2. Strategi Kebijakan Pemanfaatan Jasa Lingkungan Air secara Berkelanjutan di Taman Nasional Gunung Ciremai Kuningan-Jawa Barat

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    Rismunandar Rismunandar

    2016-12-01

    Full Text Available Mount Ciremai National Park (TNGC requires institutional policies for managing environmental services. This study aims to determine the sustainable management policy strategy for water environmental services, based on ecological, social and economical assessment. The approach used in this study is "multidimensional scaling" (MDS through the analysis of RAP-JASLING AIR (Rapid Appraisal Sustainability Index for Jasling Air to determine sustainable and performance of the management; and analysis of prospective to determine the policy strategy. The results shows that the ecological dimension index for TNGC in three areas, namely southern and central regions is quite sustainable and less sustainable for northern region. The economic dimension index for three regions seems to be less sustainable. The social dimension index for the three regions is quite sustainable. Intervention and improvements in attributes of each dimension needs to be implemented in order to reach sustainability in the future. On the other hand, prospective analysis resulted in four key factors that influence the policy of water environmental services in TNGC area and possibly to become alternative strategy for management policies, namely: management support for TNGC, income of community living in surrounding TNGC, efforts to improvecommunity's income, and protection of water springs.

  3. PROBABILITAS PULIH PADA BALITA KURUS DAN KURUS SEKALI MENURUT KEPATUHAN MENGIKUTI PEMULIHAN SECARA RAWAT JALAN DI KLINIK GIZI BOGOR

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    Sri Muljati

    2012-11-01

    Full Text Available THE PROBABILITY OF NUTRITIONAL STATUS IMPROVEMENT AMONG WASTING CHILDREN ACCORDING TO ROUTINE VISITS TO KLINIK GIZI BOGOR.Background: Prevalence of malnutrition on todler in Indonesia still high. It's an indication that nutrition prevention is not yet safisfiying. SKRT 2004 data shows that 9.3% todler in the cities and 11.1% In the village include in category at thin and very thin. Data from departement of health of RI 2005, Prevalence of malnutrition on todler is still on 19.2% and severe malnutrition is 8.8%. Bogor nutritional clinic is already develop severe malnutrition treament by out patient.Aims: To analize data of nutritional clinic visitors on 2001-2005. To now the probability of cured until Z_skore ≥ -2.5 SD dan Z_skore ≥ -2.0 SD, by using weight for height index on thin todlers and very thin todlers after six months of treatment. Methods: 294 todlers are devided in to two categories, which are 192 thin subject (≥-3SD s/d <-2 SD and 102 very thin (<-3 SD or thin with clinical indication. Inclution criteria in this anallsis, that the subject doesn't have such as down syndrome, heart disorder, thalasemia, hydrocephalus and microcephalus. Results: The study revealed that father education, mother age, todler age and compliance of treatment were correlated with probability of cured until Z_skore ≥ -2.5 SD dan Z_skore ≥ -2.0 SD, on thin todlers and very thin todlers after six months of treatment.Keywords: severe wasting, under five years, compliance

  4. ANALISIS SISTEM INFORMASI AKUNTANSI PEMBELIAN BAHAN BAKU SECARA TUNAI GUNA MENINGKATKAN EFEKTIVITAS PENGENDALIAN INTERN PADA PT. DWI MULYO LESTARI MADIUN

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    Fefi Wuri Ambarwati

    2016-11-01

    Full Text Available This study evaluates the raw material purchasing system are applied in PT. Mulyo Dwi Lestari in order to enhance the effectiveness of internal control. The data was collected using interview and observation techniques. The analysis conducted is qualitative descriptive analysis. Based on the research that has been done, researchers can take the conclusion that the implementation of raw material purchasing system in the PT. Mulyo Dwi Lestari not support the effectiveness of internal control. The weaknesses include there isn’t form of purchase orders, goods receiving report form is not suitable with the basic principles of design, a dual function in the barn, yet numbered printed form, and never made a sudden inspection of the accounting records company's physical wealth.

  5. Sistem kontrol inventori pemasokan barang Secara Real Time Menggunakan Vendor-Managed Inventory (VMI dan Short Message Service (SMS

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    Rinaldo Turang

    2016-01-01

    Full Text Available This research underlines the urgency of real-time stock replenishment control system for distributors using vendor-managed inventory. It is valuable in improving corporate performance in lowering inventory cost as well as making better customer service due to the cut made in ordering cycle. The system produces real-time information on stock available at the retailing stores. Stock replenishment can then be done by the distributor at the right time. Using Short Message Service (SMS as a one-way information channel from retailers to their distributor, the data of every transaction of the supervised item are processed by a rule-based forward-chaining inference system to determine the item’s availability in stores. Folowing steps in Rapid Application Development (RAD, the construction of this system takes place through business modeling, data modeling, process modeling of VMI system, then the application is generated and tested as a prototype. The results are: the stock replenishment control system are able to make transactional data at the stores transparent to the distributor, facilitating the continuation in stock delivery. System architecture reduces the time needed to access information about sales on supervised item by using SMS shortcut. This control system developed in stores can be operationally independent from the retailing systems. Rule-based forward-chaining inference technique processes facts on stock variations, resulting in stock replenishment notification such as normal, reserve, and depleted warning. Keywords: VMI, inventory; Stock replenishment; Rule-based reasoning; Forward-chaining system, RAD

  6. Pertumbuhan dan Produksi Reserpin Kalus Pule Pandak [Rauvolfia serpentina (L. Bentham ex. Kurz.] pada Pemberian Metil Jasmonat secara in Vitro

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    ENDANG ANGGARWULAN

    2005-11-01

    Full Text Available The aim of this research was to know effect of methyl jasmonate addition in any concentration on the callus growth and alkaloid reserpine production from in vitro culture of pule pandak [Rauvolfia serpentina (L. Bentham ex. Kurz.]. The research frame based on the advantage of pule pandak as medicine plants sources. The addition of methyl jasmonate on the callus medium would inhibit the callus growth. It also has effects for the synthesis stricthosidine synthase. This enzyme had essential role on the reserpine biosynthesis. The research was conducted of two steps. First, initiation step to induct the callus formation. Second, treatment step to induct reserpine production. The research was done by designing a factor random completed, that is methyl jasmonate concentration. Methyl jasmonate concentration which is 0 μM, 10 μM, 20 μM, 40 μM, 80 μM, and 100 μM. The result data was qualitative form, that was callus morphology and quantitative form, fresh weight and dried weight, and reserpine content. The analysis of data used the ANOVA and DMRT 5%. The result of this research indicated that increasing of methyl jasmonate addition reduced the callus growth. The more methyl jasmonate concentration (10, 20, 40, 80 μM was added, the higher reserpine was produced. Methyl jasmonate concentration in 80 μM produced the highest reserpine content that is 0.75 mg/g.

  7. Penetapan Kadar Campuran Isoniazid Dan Vitamin B6 Dalam Sediaan Tablet Secara Spektrofotometri Ultraviolet Dengan Perhitungan Multikomponen Dan Persamaan Matriks

    OpenAIRE

    Sari, Wardah Kumala

    2011-01-01

    Isoniazid is a drug that is effective in the treatment of tuberculosis. In trading Isoniazid is often combined with Vitamin B6 which aims to prevent side effects of Isoniazid in the form of peripheral neuritis. The combination of active ingredients that can cause problems in quantitative analysis for quality control preparations. In this research, determination of the combination tablet Vitamin B6 and Isoniazid by Ultraviolet spectrophotometry with multicomponent calculation and use the matri...

  8. Penetapan Kadar Campuran Rifampisin dan Isoniazid dalam Sediaan Tablet Secara Spektrofotometri Ultraviolet dengan Metode Panjang Gelombang Berganda

    OpenAIRE

    Sitorus, Riris Anugrah Rema

    2016-01-01

    The drugs used for tuberculosis were classified into two groups, there is primary drugs and secondary drugs. Rifampicin and isoniazid are the primary drugs. Combination of rifampicin and isoniazid in the tablet is one of the drugs that used in tuberculosis treatment. Combination of rifampicin and isoniazid in the tablet is one of the drugs that used in tuberculosis treatment. The purpose of this study is to determination value of rifampicin and isoniazid in tablets which circulates in the gen...

  9. PEMBAGIAN KERJA SECARA GENDER DALAM PEMBERDAYAAN PANGAN LOKAL (STUDI KASUS DI DESA MOROREJO KECAMATAN TEMPEL KABUPATEN SLEMAN

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    Mesalia Kriska

    2017-01-01

    Full Text Available ABSTRACT This research aims to know about gender division of household labor in the empowerment of local food in Tempel Sub-District, Sleman Regency. Research method that is used was qualitative methods with case study approach. This research held in Mororejo Village, Tempel Sub-District. This location selected purposively because that village is the only one village which has the group of local food empowerment. Data gathered by participatory observation, interview, and documentation. The results showed that women dominated in every empower activity, that is training of local food processing, arisan, local food contests, and making the product at home. Man in household only involved in a hard work that need more power, like harvesting the cassava as a main ingredient and support activity for his wife, that is accompany his wife to go shopping at traditional market. In this case, there was gender relations in the empowerment activity of local food.

  10. Rule Based Reasoning Untuk Monitoring Distribusi Bahan Bakar Minyak Secara Online dan Realtime menggunakan Radio Frequency Identification

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    Mokhamad Iklil Mustofa

    2017-05-01

    Full Text Available The scarcity of fuel oil in Indonesia often occurs due to delays in delivery caused by natural factors or transportation constraints. Theaim of this  research is to develop systems of fuel distribution monitoring online and realtime using rule base reasoning method and radio frequency identification technology. The rule-based reasoning method is used as a rule-based reasoning model used for monitoring distribution and determine rule-based safety stock. The monitoring system program is run with a web-based computer application. Radio frequency identification technology is used by utilizing radio waves as an media identification. This technology is used as a system of tracking and gathering information from objects automatically. The research data uses data of delayed distribution of fuel from fuel terminal to consumer. The monitoring technique uses the time of departure, the estimated time to arrive, the route / route passed by a fuel tanker attached to the radio frequency Identification tag. This monitoring system is carried out by the radio frequency identification reader connected online at any gas station or specified position that has been designed with study case in Semarang. The results of the research covering  the status of rule based reasoning that sends status, that is timely and appropriate paths, timely and truncated pathways, late and on track, late and cut off, and tank lost. The monitoring system is also used in determining the safety stock warehouse, with the safety stock value determined based on the condition of the stock warehouse rules.

  11. Perancangan Aplikasi Game Warung Sate Lilit Bali Berbasis Android Sebagai Media Pembelajaran Pengenalan Sate Lilit Secara Sederhana

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    I Made Ageng Suyasa

    2017-08-01

    Full Text Available The typical food of an area is one of the cultural heritage of regions that should be preserved and maintained so the extinction never crushed by the time. Sate lilit is one of the typical foods in Bali. Sate lilit is processed by meats that are chopped and blended using a wide range of the balinese wrapped around or taped in a stalk of bamboo and then baked in hot coals. Warung Sate lilit game are aiming to introduce the general public and younger generation in particular how to make  sate in a simple one turn, as well as aimed at the medium of learning are expected to support the preservation of sate lilit of Bali. Warung Sate Lilit Bali game is expected to increase the interest of the younger generation about satay lilit as the typical food of Bali. Warung Sate Lilit Bali  game be played by the drag and drop method, so the user simply choose the materials provided by, then comes the bar to determine the dose of materials that are required to fulfill orders from buyers. Warung Sate Lilit Bali  game are provide learning via the information contained on the menu ingredient which has been available and also get learning to play, because at the time to drag and drop the materials, the players knowing what course the necessary materials for making the sate lilit turn a simple.

  12. PENGARUH PERKEMBANGAN TEKNOLOGI INFORMASI TERHADAP KEABSAHAN PERJANJIAN DALAM PERDAGANGAN SECARA ELEKTRONIK (E-COMMERCE DI ERA GLOBALISASI

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    Lathifah Hanim

    2011-02-01

    Full Text Available Economic activity in the entire world with the existence of existence is increasingly dependent telematic technology. The development of Information technology giving influence on the validity of contracts in electronic commerce (E-Commerce in the era of globalization and the what’s factors constraints on the validity of contracts in electronic commerce (E-Commerce in the era of globalization. Article 1320 Civil Code is the principal instrument to test the validity of contracts made by the parties. Article 1320 Civil Code there are four legal conditions of contract, namely: agreements, the ability to create engagement, a certain thing, and a lawful reason. Contracts that do not meet the agreement and skill, resulting in the contract to cancel and void by law, if there are contracts that do not qualify or do not have a specific object or cause is not allowed, the resulting contract is null and void.

  13. PENGARUH PERKEMBANGAN TEKNOLOGI INFORMASI TERHADAP KEABSAHAN PERJANJIAN DALAM PERDAGANGAN SECARA ELEKTRONIK (E-COMMERCE DI ERA GLOBALISASI

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    Lathifah Hanim

    2011-03-01

    Full Text Available Economic activity in the entire world with the existence of existence is increasingly dependent telematic technology. The development of Information technology giving influence on the validity of contracts in electronic commerce (E-Commerce in the era of globalization and the what’s factors constraints on the validity of contracts in electronic commerce (E-Commerce in the era of globalization. Article 1320 Civil Code is the principal instrument to test the validity of contracts made by the parties. Article 1320 Civil Code there are four legal conditions of contract, namely: agreements, the ability to create engagement, a certain thing, and a lawful reason. Contracts that do not meet the agreement and skill, resulting in the contract to cancel and void by law, if there are contracts that do not qualify or do not have a specific object or cause is not allowed, the resulting contract is null and void.   Keywords: E-commerce, validity of agreement

  14. Karakteristik Total Padatan Tersuspensi (Total Suspended Solid Dan Kekeruhan (Turbidity Secara Vertikal Di Perairan Teluk Benoa, Bali

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    I Gede Hendrawan

    2016-06-01

    Full Text Available Benoa bay is one of estuary that located in the Southern part of Bali Island, and as a strategic tourism destination. The increased of the human activity has an important role to give an ecological pressure for the seawater ecosystem in the Benoa bay. Total suspended solid (TSS and turbidity is one of the important indicators that could be determining the quality of the seawater. As the estuary, Benoa bay received fresh water from the river discharge that also potentially carries any material to the bay. In addition, port activity is also has an important role in contributing a various material to the Benoa bay. From this research, we found that the TSS concentration and the turbidity are higher in the surface water and also in the bottom layer. TSS concentration and the turbidity also varied from the bay mouth trough the line of vessel onto the inner of bay. TSS concentration and turbidity in the bay mouth has a smaller concentration rather than in the inner part of bay. TSS concentration and turbidity in the inner of bay could be caused by the port activity. In addition, seawater circulation is also has an importan factor to contributing the TSS concentration and the turbidity. Sea current would be erroted the seabottom and with the different shape of the topography could be increased the TSS and turbidity.

  15. Visualisasi Hasil Mesin Uji Tarik Gotech GT-7010-D2E dalam Bentuk Grafik secara Real Time

    OpenAIRE

    Anggoro Suryo Pramudyo; Andi Rachmansyah; Suhendar

    2014-01-01

    Gotech GT-7010-D2E is a tensile testing machine used in Metallurgical Engineering Laboratory UNTIRTA. The machine are used both for practical and Materials Engineering specimen testing demanded by several industries. The machine can perform tensile tests well, but for the analysis is done manually, so it requires a lot of time and accuracy of the analysis results are not very accurate. Therefore, it’s needed a software that can analyze the results of the tensile test in the form of graphs in ...

  16. Visualisasi Hasil Mesin Uji Tarik Gotech GT-7010-D2E dalam Bentuk Grafik secara Real Time

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    Anggoro Suryo Pramudyo

    2014-03-01

    Full Text Available Gotech GT-7010-D2E is a tensile testing machine used in Metallurgical Engineering Laboratory UNTIRTA. The machine are used both for practical and Materials Engineering specimen testing demanded by several industries. The machine can perform tensile tests well, but for the analysis is done manually, so it requires a lot of time and accuracy of the analysis results are not very accurate. Therefore, it’s needed a software that can analyze the results of the tensile test in the form of graphs in real time. Software visualization is created using Visual Basic 6.0 and data from tensile testing machine is stored using Microsoft Access database. The software is designed to record any characters that appear in the LCD on the control panel of a tensile testing machine and then process them to be a graphic. Based on the results of the implementation of the specimen plate and wire observations prove that the difference between the use of visualization software is more accurate and effective in their use of time, compared to manual observation that requires further analysis of the test results. In software visualization results of tensile test, the mechanical properties can be analyzed directly from the test results and graphs of data obtained in real time.

  17. Sistem Keamanan Berlapis pada Ruangan Menggunakan RFID (Radio Frequency Identification dan Keypad untuk Membuka Pinta Secara Otomatis

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    Muhammad Chamdun

    2014-10-01

    Full Text Available This final project aims to design a door security device using RFID technology (Radio Frequency Identification and the keypad as a method of access into the room. The system will automatically give warning when the code is entered incorrectly or burglars entered by breaking the door. The microcontroller that is used as the central data processing is ATMega 16 microcontroller ATMEL production and security sensors are used PIR (Passive Infra Red and magnetic switches. The design begins with a schematic device hardware and software design using CodeVisionAVR programming. Implementation phase includes the implementation of the physical tools, programs, and sensors. The testing phase is done by testing the input sensors and exit switches, siren output devices, DC motor, LCD (Liquid Crystal Display, the RFID reader, keypad, and system controller. The results of room layered security system works according to design. PIR sensors can detect human activities and turn the LED lamp indicator on. Magnetic switch sensors will provide input to the microcontroller to enable or disable the DC motor as the room locking system. Admin menu that is accessed from the keypad is to add users, remove users, see registered users and change the password. User menu which is also accessed using the keypad, work as the room access using a username and password. This study resulted in the layered security. Room access is done using RFIDTag and password. The room piercing detection is done by sensor PIR (Passive Infra Red and magnetic switches. Alarm used as a piercing action warning. This layered room safety device produces a better security system.

  18. Pengendalian Nematoda Parasitik Tanaman secara Hayati dengan Bakteri Pasteuria penetrans: Inventarisasi, Pembiakan Massal, dan Uji Patogenisitas Isolat Bakteri

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    Mulyadi Mulyadi

    1995-12-01

    Full Text Available The research on “Biological control of plant parasitic nematodes by nematophagous bacteria (Pasteuria penetrans” was planned to be conducted within 3 years period, started in 1994/1995. In the first year research was done with the following objectives: 1 inventory on the isolates of P. penetrans, and 2 study on the mass production and pathogenicity test of P. penetrans. Survey of P. penetrans was done in the provinces of D.I. Yogyakarta, Central Java, East Java, and West Java. Soil and root samples were collected in this survey, plant parasitic nematodes were isolated using centrifugation and funnel and spray method. Mass production of P. penetrans was done with their host especially root-knot nematodes (Meloidogyne spp.. The bacterial infected nematodes were inoculated on tomato  planted on sterilized soil. Roots contain root-knot nematodes inhabiting spores of P. penetrans were used as inoculum source. The pathogenicity tests of the isolates were done using bioassay method and in the green house in Completely Randomized Design. The research results is as follows: 1 seventeesn isolates of P. penetrans were found in the survey, these isolates were pathogenic to root-knot nematodes, 2 mass production of P. penetrans was done with their host especially root-knot nematodes and 4 treatment with P. penetrans significantly reduced the root-gall caused by root-knot nematodes. Key words: biological control, parasitic nematodes, Pasteuria penetrans

  19. Substitusi Medium Sintetik dengan Pupuk Daun, Air Kelapa dan Ekstrak Nabati pada Subkultur Anggrek Cattleya pastoral Innocence secara In Vitro

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    Etty Handayani

    2014-08-01

    Full Text Available A research was perfomed to find the proper of coconut water and natural ekstracts combined with Hyponex medium that compared with Vacin & Went medium. This research has been done at Tissue Culture Laboratory, Agricultural Faculty, Universitas Muhammadiyah Yogyakarta. The method of this research was arranged in Randomized Complete Design with 9 treatments and 8 replications. The treatments were VW + NAA 0,5 ppm + BAP 3 ppm, green Hyponex 3 g/l, green Hyponex 3 g/l + bean sprouts 150 g/l, green Hyponex 3 g/l + tomatoes 150 ml/l, green Hyponex 3 g/l + avocado 150 g/l, red Hyponex 3 g/l, red Hyponex 3 g/l + bean sprouts 150 g/l, red Hyponex 3 g/l + tomatoes 150 ml/l, red Hyponex 3 g/l + avocado 150 g/l. The each of Hyponex mediums were given with bananas 150 g/l and coconut water 150 ml/l. The result of this research showed that Hyponex mediums combined with natural ekstract was not signicicantly with Vacin & Went medium to high and shoot growth. Red Hyponex medium 3 g/l combined bananas 150 g/l and coconut water 150 ml/l resulted the best high, leaf and shoot in tissue culture Cattleya pastoral innocence orchid.

  20. DAYA HAMBAT EKSTRAK ETANOL KULIT BUAH PISANG KEPOK MENTAH (Musa paradisiaca forma typica TERHADAP PERTUMBUHAN Escherichia coli SECARA IN VITRO¬

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    Novia Ariani

    2017-10-01

    Full Text Available Banana plants is the most one that produce and used by Indonesian people. Banana plants has a lot of kind, and the one is kepok banana. Kepok banana peel has used to make some kind of foods but for drug use is still limited whereas in banana peel contains secondary metabolites flavonoids, alkaloids, saponins and tannins has antibacterial activity. The purpose of this research was to determine resistivity of peel extract of raw banana kepok (Musa paradisiaca forma typica on the growth of Escherichia coli in vitro. This type of research is non experimental with the method of wells conducted in the laboratory of Microbiology of Pharmacy Academy of ISFI Banjarmasin. The sampling used by purposive sampling technique with certain criteria. To determination of resistibility saw the transparent zone around the well. The results of this research showed that bark extract of raw banana peel extract had inhibitory power to growth of Escherichia coli in vitro.

  1. Pemodelan Molekul Turunan p-Metoksi sinnamoil Hidrazida Sebagai Inhibitor Checkpoint Kinase 1 dan Inhibitor Aromatase secara In silico

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    Galih Satrio Putra

    2017-08-01

    Full Text Available The development of anticancer drugs from ethyl p-methoxycinnamate (EPMC derivatives continues to obtain compounds that have high ability of cancer cells apoptosis and minimal side effects. p-Methoxycinnamoyl hydrazide derivate compounds from EPMC structure modification were docked into the ligand-binding pocket of Check point kinase 1 enzymes (2YWP and the aromatase enzyme (3S7S using software Molegro Virtual Docker (MVD Ver.5.5. We compared the Rerank score of native ligand with derivate compounds of p-Methoxycinnamoyl hydrazide. Rerank scores of compounds 4b and 4c (-99.98 Kcal/mol and -99.80 Kcal/mol were lower than the native ligand A42 in inhibiting the enzyme checkpoint kinase 1. Rerank values of p-Methoxycinnamoyl hydrazide derivate compounds were greater than the native ligand EXM in inhibiting the enzyme aromatase. p-Methoxycinnamoyl hydrazide derivate compounds, especially compounds 4b and 4c, had anticancer mechanism by inhibiting the enzyme pathway checkpoint kinase 1 and had not activity in inhibiting the aromatase enzyme.

  2. Upaya Meningkatkan Kualitas Bokashi Melalui Pemberian Cangkang Telur, Abu Dapur, Dan Urine Sapi Serta Penerapannya Dalam Budidaya Sawi Secara Organik

    OpenAIRE

    Walunguru, Lena; Lende, Aloysius Ng

    2008-01-01

    Increasing Quality of Bokashi by Apply Eggshell Powder, Ash, and Cow Urine and Application in Cultivation of Organic Mustard Green. The research aimed to know quality of bokashi added eggshell powder, ash, and cow urine to plant productivity.The research used Completely Randomized Block Design consisting of eight treatments were bokashi (B0), bokashi added eggshell powder (B1), bokashi added ash (B2), bokashi added cow urine (B3), bokashi added eggshell powder and ash (B4), bokashi added egg...

  3. SELEKSI DAN PEMANFAATAN ACTINOMYCETES SEBAGAI MIKROBA ANTAGONIS YANG RAMAH LINGKUNGAN TERHADAP Fusarium oxysporum f.sp. cubense SECARA IN VITRO

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    I MADE SUDARMA

    2015-06-01

    Full Text Available A total of 119 different actinomycete isolate were recovered from banana crop habitats with and without Fusarium wilt disease symptom. These were than assessed for their antagonist ability against Fusarium oxysporum £sp. cubense (Foe in vitro. Results indicated that four of all actinomycete isolate active against Foe. The four of actinomycete isolates were Streptomyces sp. l (AAo4, Streptomyces sp.2 (AAo32 , Streptomyces sp.3 (AAo33 and Streptomyces sp. 4 (AAo35. It was can inhibit the Foe mycelium growth, 79,63%, 72,22%, 78,89% and 72,22% respectively. After tested with the 3 times replication, the four Streptomyces spp. isolate effective to control the Foe that attack Bali banana cultivars, such as Susu, Saba, Raja and Ketip.

  4. REGENERASIRUMPUT LAUT Kappaphycus alvarezii (Doty MELALUI INDUKSI KALUS DAN EMBRIO DENGAN PENAMBAHAN HORMON PERANGSANG TUMBUH SECARA IN VITRO

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    Emma Suryati

    2009-04-01

    Full Text Available Regenerasi rumput laut Kappaphycus alvarezii dilakukan dalam rangka penyediaan benih yang bermutu dan mempunyai keunggulan melalui induksi kalus dan embrio dengan penambahan hormon pertumbuhan yang diintroduksi ke dalam media kultur yang dapat memacu induksi kalus dan penebalan pigmen rumput laut. Media kultur yang digunakan adalah media Conwy padat dengan penambahan agar 0,8%-1,6%. Hormon perangsang tumbuh yang digunakan untuk memacu pertumbuhan kalus dan filamen embrio yaitu IAA (Indol acetic acid, kinetin, dan auxilin dengan konsentrasi berkisar 0,4-1 mg/L. Embrio yang dihasilkan merupakan anakan yang mempunyai sifat yang sama dengan induknya. Sintasan dan perkembangan embrio yang paling baik yaitu dengan penambahan IAA dengan konsentrasi 0,4 mg/L pada media padat. Pembentukan anakan dilakukan dengan mengiris embrio dan menumbuhkan pada media cair yang diperkaya dengan hormon yang sama. Pemeliharaan anakan pada media kultur dilakukan hingga mencapai ukuran 2-3 cm. Regeneration of seaweed Kappaphycus alvarezii was done to provide high quality seed through callus and embryo induction using plant growth regulator which was introducted to the culture medium. This growth regulator can stimulate the callus induction procces and thickening the seaweed pigment. Applied medium culture was agar medium with 0.8%-1.6% concentration enriched with Conwy and the applied growth regulators were IAA (Indol acetic acid, kinetin dan auxilin with 0.4-1 mg/L concentration range. Resulted embryo has the same characteristics with the stock. The best survival rate and embryo growth was IAA treatment with 0.4 mg/L concentration. Formation of embryo was done by transferring them from solid medium to the liquid one with the same growth regulator treatment. The nursery of the seed in culture medium was carried out until it has reached 2-3 cm in size.

  5. Uji Antagonis Trichoderma harzianum Terhadap Fusarium spp. Penyebab Penyakit Layu pada Tanaman Cabai (Capsicum annum) Secara In Vitro

    OpenAIRE

    Mukarlina; Khotimah, Siti; Rianti, Reny

    2010-01-01

    Fusarium spp., the causal agent of Fusarium wilt disease, infect sweet pepper inflicting damages on the roots, stems, leaves, flowers, and fruits. Infection of Fusarium spp. on some crops can be controlled by using Trichoderma harzianum as a biological control agent. The aims of this study were to determine: 1) the species of Fusarium infecting sweet pepper; and 2) the in vitro antagonistic potential of T. harzianum in controlling Fusarium spp. in vitro. The study was conducted fr...

  6. MODEL PERUBAHAN VOLUME KERIPIK BUAH SELAMA PROSES PENGGORENGAN SECARA VAKUM [Model for Volume Changes in Fruit Chips during Vacuum Frying

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    Jamaluddin1*

    2011-06-01

    Full Text Available Expansion and puffing are specific characteristics of fried products critical for consumer preferences. To obtain expanded and puffed dried products that fit well with consumer acceptance criteria, it is necessary to pay attention to the process conditions which change the raw material characteristics during frying. The important changes include volume and density ratio of the products during frying. Hypothetically, these changes are due to water vaporization and the decrease dry matter in the products. The objective of this research is to develop a mathematical model of volume and density ratio changes for jack fruit during vacuum frying as a function of water and starch content reductions. Samples were vacuum fried at 70–100OC and pressure of 80-90 kPa for 15–60 min. The parameters observed were volume and density as well as water and starch contents of samples before and after vacuum frying. The results showed that the developed model can be used to predict changes in volume and density ratio of jack fruit during vacuum frying.

  7. Perbandingan Pemberian Metoprolol Tartrat dengan Lidokain secara Intravena terhadap Perubahan Tekanan Darah dan Laju Nadi Akibat Tindakan Laringoskopi dan Intubasi

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    Yovita Koswara

    2014-08-01

    Full Text Available Laryngoscopy and endotracheal intubation associated with a sudden rise in blood pressure and pulse rate due to stimulation of sympathetic activity. The aim of this study was to compare effectiveness of metoprolol 5 mg intavenously and lidocaine 1.5 mg/kgBW to attenuate hemodynamic response evoked by laryngoscopy and intubation. This was an experimental randomized double blind controlled trial study was conducted in 40 patients with American Society of Anesthesiologist (ASA physical status I or II who will have surgery with general anesthesia techniques in Hasan Sadikin Hospital Bandung from July−August 2013. Subjects were divided into two groups wich received metoprolol 5 mg intravenously or lidocaine 1.5 mg/kgBW 3 minutes before laryngoscopy and intubation. All data were analysed using t-test, with p value < 0.05 considered significant. Statistical analysis showed that on second and third minutes after intubation and laryngoscopy showed a significant differences on hemodynamic parameter between two groups with p value <0.05. The conclusions of this study are intravenous 5 mg of metoprolol found to be better than lidocaine 1.5 mg/kgBW to attenuate hemodynamic response evoked by laryngoscopy and intubation.

  8. Isolasi Minyak Atsiri dari Sereh Merah (Andropogon citratus DC.) Segar dan Kering Serta Analisis Komponen Secara GC-MS

    OpenAIRE

    Situmorang, Betty Meilya

    2013-01-01

    Essential oil is a term used for volatile oil and obtained from part of plant such as leaves, flowers, fruit, bark and roots. Lemongrass oil is a major export commodities among the various types of essential oil. The main content of lemongrass oil are sitronellal and geraniol, and content oil of lemongrass is 0.5 to 1.2%. Andropogon citratus DC. of the family Poaceae is one of plant that contains essential oil and is widely used as a liniment. The objective of this research is to determine th...

  9. PENGARUH KOMBINASI MACAM ZPT DENGAN LAMA PERENDAMAN YANG BERBEDA TERHADAP KEBERHASILAN PEMBIBITAN SIRIH MERAH (Piper crocatum Ruiz & Pav SECARA STEK

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    Eko Anang Budianto

    2013-09-01

    Full Text Available Medicinal plants is one of Indonesia's agricultural potential to be developed and one of the medicinal plants that have bright prospects for the development of red betel, because in addition to be consumed as a medicinal plant, also as an ornamental plant. Effect of combination treatment with a long range of ZPT different immersion able to stimulate root growth in cuttings of red betel. This study aims to determine the effect of PGR combination with a long range of different immersion to the successful breeding of red betel cuttings. The study was conducted at the experimental farm of Agricultural Faculty of the University Trunojoyo Madura, in January to April 2012. The research method used was Randomized Design Group (RAK single factor with seven treatments and repeated four times. Range of ZPT is used there are two, namely IBA and NAA, while the use of immersion time is one hour, two hours and three hours. The results showed that the IBA with a three-hour long immersion gives a significant influence on the variable root length, root number and root dry weight, whereas NAA with the old one-hour immersion is a very real influence on the observations of variable length and dry weight of leaf buds.Keyword : red betel, ZPT, IBA, NAA

  10. Identifikasi Pewarna Sintesis Pada Minuman Serbuk Rasa Jeruk Secara Kromatografi Kertas Di Balai Besar Pengawas Obat Dan Makanan

    OpenAIRE

    Jawari, Amalia Putri

    2015-01-01

    Identification has been made of synthetic dyes contained in the powder drink orange flavor in Chromatography Paper at the Center for Food and Drug Administration. Solvents are used to determine the synthesis of dyes is the ratio of the volume of isobutanol: ethanol: water is 3: 2: 2 and trisodium as elution and with Methilen Yellow, Ponceau 4 R, Tartrazine, and Yellow FCF / Sunset Yellow as a solution Baku. From the results of the analysis obtained dye Sunset Yellow and Tart...

  11. Pendeteksian Kerapatan dan Jenis Gulma dengan Metode Bayes dan Analisis Dimensi Fraktal untuk Pengendalian Gulma secara Selektif

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    Mohamad Solahudin

    2010-10-01

    Full Text Available Destructive impacts of herbicide usage on environment and water contamination have led to many researches oriented toward finding solutions for their accurate use. If density and weeds species could be correctly detected, patch spraying or spot spraying can effectively reduce herbicide usage. A precision automated machine vision for weed control could also reduce the usage of chemicals. Machine vision is a useful method for segmentation of different objects in agricultural applications, especially pattern recognition methods. Many indices have been investigated by researchers to perform weed segmentation based on color information of the images. But there is no research that aims to identify weed diversity and its influence on the consumption of herbicides. The purpose of this research is to build a system that can recognize weeds and plants. In this study the relation between three main components (red, green and blue of the images and color feature extraction (Hue, Saturation, Intensity used to define weeds and plants density. Fractal dimension used as the methode to define shape features to distinguish weeds and plants. Weeds and plants were segmented from background by obtaining H value and its shape was obtained by fractal dimension value. The results show fractal dimension value for weeds and plants has specific values. Corn plants have fractal dimension values in the range 1.148 to 1.268, peanut plants have fractal dimension values in the range 1.511 to 1.629, while the weeds have Fractal dimension values in the range 1.325 to 1.497.

  12. Pengawetan Kayu Gubal Jati Secara Rendaman Dingin dengan Pengawet Boron untuk Mencegah Serangan Rayap Kayu Kering (Cryptotermes cynocephalus Light.

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    Afif Sumaryanto

    2015-10-01

    The utilization of younger teakwood has a disadvantage, which is the sapwood is more susceptible to dry wood termites as it has less natural durability. Boric acid and borax are inexpensive preservatives, which contain boron as the active material. Those preservatives are also easy to be obtained as well as do not produce smells and the wood discoloration. The experiment materials were the sapwood parts from teak boards obtained from the felled trees in the community forest of Kali Bawang, Kulon Progo. A complete randomized block design was arranged in a factorial with two factors, which were the type of preservatives (boric acid and borax in 5% concentration and duration of cold soaking (12, 24, 36, and 48 hours. To examine the durability of sample, dry wood termites (Cryptotermes cynocephalus Light were used. The results showed that the average values of absorption, retention, and depth of penetration were 33.09 to 70.77 kg/m3, 3.81 to 10.77 kg/m3, and 2.34 to 3.86 mm, respectively. The average values of termite mortality during 2 weeks and 4 weeks were 46.33 to 53 %, 82.67 to 94.33 %. Weight reduction and degree of the damage were, 560 to 570 mg, and 30.34 to 31.27 %, respectively. By analysis of variance, there was an interaction between the type of preservatives and the duration of cold soaking factors, which affected significantly the termite mortality. Type of preservative affected significantly the absorption and penetration. Further, the duration of cold soaking affected significantly the level of absorption, retention and penetration. The application of preservatives could reduce the mass loss of specimens until 70 % as well as to give higher levels of mortality rate (87-92 % compared to that of untreated one.

  13. PERENCANAAN VIRTUALISASI LAYANAN PENGADAAN SECARA ELEKTRONIK PEMERINTAH KABUPATEN BADUNG MENGGUNAKAN METODE BLUE OCEAN STRATEGY DAN BALANCED SCORECARD

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    Made Aryawan

    2016-11-01

    Full Text Available Abstract --- The main obstacles holding LPSE in Indonesia today is the limited available resources (infrastructure and competent human resources so it needs proper governance to maintain the availability of service in order to increase the procurement credibility of government goods or services. Virtualization Technology Utilization proposed as an alternative solution considering the efficiency, effectiveness and ease of maintenance, is considered able to accelerate the realization of a reliable and accountable LPSE so it can increase the participation of service users. This research discussed the Planning of Virtualization based on Blue Ocean Strategy analyses (BOS and Balanced Scorecard (BSC, where the virtualization creates innovations value for LPSE Badung and becomes a real step towards BOS considering it has not been widely adopted by other LPSE. BOS gives a picture of the current organization and desired ideal condition, while the optimization and management of variable accuracy achieved through the implementation of Key Performance Indicators / KPI from various perspectives within the framework of the BSC. Canvas mapping strategy in this research, produce four steps framework namely: (1 the elimination step is to negate Internet access failure, (2 the step to reduce application error, access difficulties, the difficulties in operating the applications and connection interference, (3 the step to increase the availability of information, the speed and the smoothness of the transaction process, ease of complains, the quality of support services, data security system and (4the step to create  service interference resistance. The virtualization implementation also gives a positive value towards the performance of LPSE services in terms of user satisfaction level, where in general the achievement recorded close to the value of user expectation, even in the services related to the handling of complaints, the performance achievement showed the value that exceeds user expectation. Further optimization and virtualization planning accuracy, conducted through the establishment of 11 Key Performance Indicators / KPI in 6 perspectives is the development of the four main perspectives BSC framework.  

  14. DETEKSI CEKAMAN OKSIDATIF AKIBAT TOKSISITAS KROM PADASonchus oleraceus L. MELALUI PENENTUAN SPESIES OKSIGEN REAKTIF SECARA SPEKTROFOTOMETRI DAN HISTOKIMIA

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    Sri Kasmiyati

    2016-03-01

    Full Text Available Increased production of reactive oxygen species or ROS is one of the common responses to a wide range of biotic and abiotic stresses. Increased production of ROS is outstripping endogenous antioxidant defense systems has been referred to as oxidative stress. Heavy metals are known to initiate ROS generation which is implicated as a oxidative stress. Cr is a toxic heavy metal that can generate ROS like H2O2 and O2 - which cause oxidative stress. In this study, chromium toxicity was studied to detect the oxidative stress on Sonchus oleraceus weed plants by the detection of superoxide anion and H2O2. Superoxide anion was detected by staining techniques with nitroblue tetrazolium (NBT and hydrogen peroxide by Diaminobenzidine tetrahydrochloride (DAB staining. Results indicated that the plants were grown in sand media generate the highest (0.89 A/g FW and 3.23 mol/g FW than in soil media (0.23 A/g FW and 2.11 mol/g FW superoxide anion (*O- 2 and H2O2 and soil containing textile sludge (0.18 A/g FW and 2.66 mol/g FW, respectively. At application of 10 mg Cr6+/L and 250 mg Cr3+/L, the production of *O- 2 and H2O2 in leaves of sonchus plants were significantly increased compared with the control plants. The highest production of H2O2 and *O- 2 were showed in the leaves of sonchus plants grown in sand media with Cr6+ application. In this study, either Cr3+ or Cr6+ caused oxidative stress in Sonchus oleraceus weed plants. The result also showed that sonchus plants esposed to toxic Cr can suffer from oxidative stress leading to reduction of its fresh and dry plants biomass. NBT and DAB in an appropriate probe and significant value for monitoring the formation of *O- 2 and H2O2 in plants.

  15. PENGARUH IRADIASI SINAR GAMMA TERHADAP VARIASI PERTUMBUHAN ANGGREK Brachypeza indusiata (Reichb.f Garay SECARA IN VITRO

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    Maria Utami Dewi Wardhani

    2007-01-01

    Full Text Available A research was carried out in Orchid Laboratory of Bogor Botanical Gardens to observe the effect of gamma ray irradiation on the growth variation of Brachypezo indusiata (Reichb.f Garray and suitable culture medium for propagating the plant. The research was arranged in a factorial experiment with a Completely Randomized Design. The first factor was gamma ray irradiation on protocorm-like­bodies (plb of germinated seeds of B. indusiata in which four levels of irradiation was applied, i.e. 0, 10, 20, and 30 Gy. The second factor was the use of two different culture media, i.e. Vacin & Went medium supplemented with either banana pulp or a mixture of tomato and sprout bean as the essential organic compound of the medium. The result showed that the irradiation treatment improved the survival of B. indusiata explants, most significantly at 20 Gy level of irradiation, and could modify the growth of the resulted plantlets by reducing the height of the plant and the length and width of the leaves. The higher the level of irradiation the smaller the plantlets produced. Meanwhile, the addition of organic compound derived from banana fruit into the basal medium of Vacin & Went enhanced the growth of the plantlets better than that derived from a mixture of tomato fruit and bean sprout. However, there was no significant interaction effect detected between the irradiation treatments and the use of different culture media.

  16. Identifikasi Ras Fisiologis Fusarium oxysporum f.sp. cubense Berdasarkan Sifat Kompatibel Secara Vegetatif dan Pembentukan Bahan Volatil

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    Arif Wibowo

    2002-07-01

    Full Text Available Race characterization of F. oxysporum Schlecht. f.sp. cubense (E.F. Smith Snyd. & Hans. by determining disease reaction is difficult because the result may be biased due to the variability of growing condition. This study is aimed to identify physiological races of F. oxysporum f.sp. cubense in banana plantation in the province of Daerah Istimewa Yogyakarta by examining the relation of the fungal pathogen isolates. The identification of physiological races of F. oxysporum f.sp. cubense was based on vegetative compatibility groups (VCGs. The research was conducted in The Laboratory of Mycology Faculty of Agriculture GMU on March to November 2000. Observation of heterokarion formed by the mutant of F. oxysporum f.sp. cubense on selective medium was carried out in order to identify the compatibility of two different fungal isolates. Nitrate non utilizing (nit mutants obtained without mutagen were used as the label. Nit mutant obtained from the same wild type isolates could form heterokarion on minimal agar medium containing NaNO3 as nitrogen source. Eleven isolates of F. oxysporum f.sp. cubense have been isolated from several cultivars of banana. Vegetative compatibility tests showed that of 11 eleven isolates, there were six different group VCGs where four of them formed volatile compound in rice medium whereas two of them did not. Key words: Fusarium wilt, F. oxysporum f.sp. cubense, vegetative compatibility groups (VCGs

  17. Identifikasi Ras Fisiologis Fusarium Oxysporum F.sp. Cubense Berdasarkan Sifat Kompatibel secara Vegetatif dan Pembentukan Bahan Volatil

    OpenAIRE

    Wibowo, Arif; Suryanti, Suryanti; Sumardiyono, Christanti

    2002-01-01

    Race characterization of F. oxysporum Schlecht. f.sp. cubense (E.F. Smith) Snyd. & Hans. by determining disease reaction is difficult because the result may be biased due to the variability of growing condition. This study is aimed to identify physiological races of F. oxysporum f.sp. cubense in banana plantation in the province of Daerah Istimewa Yogyakarta by examining the relation of the fungal pathogen isolates. The identification of physiological races of F. oxysporum f.sp. cubense was b...

  18. Isolasi dan Identifikasi Secara Molekuler Ganoderma spp. yang Berasosiasi dengan Penyakit Busuk Pangkal Batang di Kelapa Sawit

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    Maria Indah Purnamasari

    2013-04-01

    Full Text Available A number of Ganoderma spp. isolates was isolated from oil palms attacked by basal stem rot (BSR disease in Padang and Pontianak plantations. Genetic polymorphism of these isolates was analyzed based on the internal transcribed spacer (ITS sequence of ribosomal DNA region. In addition, a restriction fragment length polymorphism (RFLP analysis was also performed to determine the association of the isolates with BSR disease. The isolated Ganoderma spp. showed high DNA polymorphism and there was no obvious genetic clustering of isolates that may correspond to their geographical position in Padang and Pontianak. This indicated that exchange of DNA between Ganoderma spp. infecting oil palm is not uncommon. This can be explained by the heterothallic nature of Ganoderma spp. in which DNA recombination occurs during sexual reproduction between different thalli. RFLP analysis showed that ITS fragments from all Ganoderma spp. isolates were digested with restriction enzymes MluI and SacI. This indicated that the anoderma spp. isolates were specific for oil palm and thus associated with the BSR.Key words: basal stem rot, Ganoderma spp., internal transcribed spacer, oil palm

  19. Seleksi Bakteri Berpotensi Probiotik dari Ikan Mas (Cyprinus Carpio Indegenous Jantho Berdasarkan Aktivitas Antibakteri secara In Vitro

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    Cut Yulvizar

    2014-06-01

    Full Text Available One of the alternatives to antimicrobials in disease control is probiotic bacteria as microbial control agents. This research was carried out to obtain indegenous isolates of probiotic bacteria from digestive tract Cyprinus carpio. Selection criteria were appointed based on the capacity to produce the antibacterial compound against the pathogen and grow at pH 2. The research was conducted from May to July 2014 at Microbiology Laboratory, Biology Department, UNSYIAH. The research was carried out by experiment laboratories. The planting of the bacteria was carried out with the pour-plate method in nutrient agar medium. The result show that there are six bacterial isolates varied morphological colony and cell and able to produce antibacterial compounds for active against A.hydrophila and E. tarda.

  20. IDENTIFIKASI DAN PENETAPAN KADAR SENYAWA KUMARIN DALAM EKSTRAK METANOL Artemisia Annua L. SECARA KROMATOGRAFI LAPIS TIPIS - DENSITOMETRI

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    Sukmayati Alegantina

    2012-08-01

    Full Text Available Abstract. Artemisia annua L. contain the active compounds include: terpenoids, flavonoids, kumarin, artemisinin acid, artennuin B, phenols, saponins, and fat. Kumarin and its derivatives have biological activity that can stimulate skin pigment, blood anticoagulation and can inhibit the effects of carcinogens. With this biological activity of kumarin, the research is done to ensure there is kumarin by identification and measure kumarin level which is contained in the Artemisia annua L. herb. The analysis methods include the extraction and fractionation. Identification and determination of level with Thin-Layer Chromatography (TLC using a Densitometer CS-9301 PC. From the result of TLC identification of kumarin standard known that Artemisia annua L extract contain kumarin compound which marked by a blue spot flouresense on standards and methanol extract of artemisia annua L. seeing under UV light at a wavelength of 366 nm with Rf value of standard and sample is 0.31, the measurement of kumarin spot with Densitometer known that kumarin concentration in the extract of Artemisia annua L. is 10.5 ul/ ml with 105% RecoveryKeywords: Artemisia annua L, kumarin, TLC-Densitometry

  1. Distribusi Nitrat dan Fosfat Secara Spasial dan Temporal Saat Musim Barat Di Permukaan Perairan Teluk Benoa, Bali

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    Ni Wayan Sukma Taraning Rahayu

    2017-08-01

    Full Text Available Benoa Bay is an estuary that effected by pollutan from river and human activity. Reasearch on spatial and temporal distribution of nitrate and phosphate has been conducted in Benoa Bay. Data was collected at water surface during ebb from December 2016 to Februari 2017. There were19 Sampling pointlocated in Benoa Bay and 6 pointslocated in rivers around Benoa Bay. Nitrate was analysed using Brucine method and phosphate was analysed using Amm-Molybdat method. The concentration of nitrate from December 2016 to February 2017 ranged from 0,036 mg/L to 1,154 mg/L and the concentration of phosphate ranged from undetectedto 0,739 mg/L. The concentration of nitrate at rivers ranged from undetectedto 3,584 mg/L andthe concentration of phosphate ranged from undetectedto2,405 mg/L. The concentration of nitrate and phosphate from December 2016 to February 2017 was fluctuating and the highest average concentration of nitrat and phosphate was found in February 2017. These was due to high rainfall in February 2017 and cause a lot of organic matters carried by the rivers into Benoa Bay. The highest distribution concentration of nitrate and phosphate was found around estuary. These due to input of organic matters from mainland through the rivers. Based on water quality standards of Bali Goverment, the concentration of nitrate and phosphate was exceeds the seawater quality standart.

  2. PEMERIKSAAN VIRUS DENGUE-3 PADA NYAMUK Aedes aegypti YANG DIINFEKSI SECARA INTRATHORAKAL DENGAN TEKNIK IMUNOSITOKIMIA MENGGUNAKAN ANTIBODI DSSE10

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    Dyah Widiastuti

    2013-09-01

    Full Text Available ABSTRACTDengue viruses, globally the most prevalent arboviruses, are transmitted to humans by persistently infectedAedes mosquitoes. The most important vector of Dengue virus is the mosquito Ae.aegypti, which should be the main targetof surveillance and control activities. Virologic surveillance for dengue viruses in its vector has been used as an earlywarning system to predict outbreaks. Detection of Dengue virus antigen in mosquito head squash usingimmunocytochemical streptavidin biotin peroxidase complex (SBPC assay is an alternative method for dengue vectorsurveillance. The study aimed to develope immunocytochemical SBPC assay to detect Dengue virus infection in headsquash of Ae.aegypti. The study design was experimental. Artificially-infected adult Ae. aegypti mosquitoes of DENV 3were used as infectious samples and non-infected adult Ae. aegypti mosquitoes were used as normal ones. Theimmunocytochemical SBPC assay using monoclonal antibody DSSE10 then was applied in mosquito head squash todetect Dengue virus antigen. The results were analyzed by descriptive analysis. The immunocytochemical SBPC assaycan detect Dengue virus antigen in mosquito head squash at day 2 postinfection. There are some false positive resultsfound in immunocytochemical SBPC assay.Key Word: Dengue, immunocytochemistry, DSSE10

  3. Penguraian Zat Warna Tartrazin pada Limbah Pencucian Mie Aceh Secara Ozonolisis dan Penyinaran Matahari dengan Penambahan Katalis ZnO

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    Bhayu Gita Bhernama

    2017-12-01

    Full Text Available People's habits in consuming Aceh noodles make the noodle industry grow rapidly, but the waste treatment process becomes less effective. In the process of making the noodles, dye waste is produced in the form of tartrazine dye and need to be processed before being disposed into the environment. The research purpose was to describe the decomposition of tartrazine using ozonolysis and solar radiation methods as one of the solutions in the waste treatment process. The use of ZnO as catalyst is to accelerate the decomposition reaction of the noodle washing wastes. The results of the analysis concluded that ozonolysis methods are more effective in decomposing tartrazine in the noodle wash wasted by solar irradiation method. The sun exposure decomposed tartrazine by 99.74% using 0.015 g ZnO for 150 min and tartrazine content obtained 0.022 mg/L with a sunlight intensity of 1.24 x 1016 cm-2 s-1. Ozonolisis exposure decomposed tartrazine by 98.68% using 0.020 g ZnO for 12 minutes and tartrazine content obtained 0.112 mg / L.

  4. Faktor-faktor yang BerhubungandenganKetepatan Diagnosis Bidan Dalam Merujuk Pasien Kasus Kehamilan dan Persalinan Risiko Tinggi Ke RSUD Arifin Achmad Provinsi Riau Tahun 2014

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    Desmariyanti .

    2015-11-01

    Full Text Available Ketepatan diagnosis merupakan ketepatan pendiagnosaan suatu kasus yang ditegakkan oleh petugas kesehatan dan telah memenuhi standar nomenklatur diagnosis. Bidan yang melakukan rujukan kehamilan dan persalinan risiko tinggi ke RSUD Arifin Achmad Provinsi Riau pada tahun 2014 sebanyak 210 kasus, dan yang tidak tepat mendiagnosis sebanyak 35 kasus (17%. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan ketepatan diagnosis bidan dalam merujuk pasien kasus kehamilan dan persalinan risiko tinggi yaitu pengetahuan, sikap, kompetensi, masa kerja dan bidan delima. Penelitian yang digunakan bersifat kuantitatif analitik observasional dengan studi penampang analitik (analitic crosssectional study. Analisis data dilakukan secara univariat, bivariat dengan uji chi square, dan multivariat dengan uji regresi logistik ganda dengan jumlah sampel sebanyak 120 orang yang diambil secara total populasi.Hasil penelitian diperoleh variabel yang berhubungan dengan ketepatan diagnosis bidan dalam merujuk pasien kasus kehamilan dan persalinan risiko tinggi adalah pengetahuan (OR:4,656; 95%CI: 1,200-18,064, kompetensi (OR:11,834; 95%CI: 1,371-102,141, dan masa kerja (OR:10,887; 95%CI: 2,657-44,602. Disarankan sebaiknya bidan mengikuti pelatihan APN, memiliki masa kerja yang optimal dan keterampilan dalam mengolah kasus kehamilan dan persalinan risiko tinggi, dan mengikuti seminar, workshop, pelatihan ataupun kegiatan yang dapat menambah ilmu pengetahuan khususnya ketepatan diagnosis kehamilan dan persalinan risiko tinggi

  5. Bacillus thuringiensis Cry1Ca-resistant Spodoptera exigua lacks expression of one of four Aminopeptidase N genes

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    Moar William J

    2005-06-01

    Full Text Available Abstract Background Insecticidal toxins from Bacillus thuringiensis bind to receptors on midgut epithelial cells of susceptible insect larvae. Aminopeptidases N (APNs from several insect species have been shown to be putative receptors for these toxins. Here we report the cloning and expression analysis of four APN cDNAs from Spodoptera exigua. Results Suppression Subtractive Hybridization (SSH was used to construct cDNA libraries of genes that are up-and down-regulated in the midgut of last instar larvae of beet armyworm, S. exigua exposed to B. thuringiensis Cry1Ca toxin. Among the clones from the SSH libraries, cDNA fragments coding for two different APNs were obtained (APN2 and APN4. A similar procedure was employed to compare mRNA differences between susceptible and Cry1Ca resistant S. exigua. Among the clones from this last comparison, cDNA fragments belonging to a third APN (APN1 were detected. Using sequences obtained from the three APN cDNA fragments and degenerate primers for a fourth APN (APN3, the full length sequences of four S. exigua APN cDNAs were obtained. Northern blot analysis of expression of the four APNs showed complete absence of APN1 expression in the resistant insects, while the other three APNs showed similar expression levels in the resistant and susceptible insects. Conclusion We have cloned and characterized four different midgut APN cDNAs from S. exigua. Expression analysis revealed the lack of expression of one of these APNs in the larvae of a Cry1Ca-resistant colony. Combined with previous evidence that shows the importance of APN in the mode of action of B. thuringiensis toxins, these results suggest that the lack of APN1 expression plays a role in the resistance to Cry1Ca in this S. exigua colony.

  6. HARMONI KEHIDUPAN SOSIAL BEDA AGAMA DAN ALIRAN DI KUDUS

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    Moh Rosyid

    2015-11-01

    secara bersama-sama antara warga, tokoh, dan perangkat pemerintahan. Warga mayoritas tidak mudah tersulut pemberitaan media dan gosip yang tertebar setiap saat untuk menerkam yang minoritas. Terwujudnya toleransi beragama antar dan intern umat beragama dapat dilakukan dengan mengoptimalkan pendekatan budaya dan keharmonisan sosial. Dengan demikian, pendekatan yang menggunakan aspek keamanan secara alami ternafikan. Kata Kunci: Nirkonflik, Antar Umat dan Intern Umat Beragama, Aliran Agama. HARMONY OF SOCIAL LIFE OF DIFFERENT RELIGION IN KUDUS. Internal and interreligious conflict has colored social reality in this country. The most important thing to solve the problem is finding its fundamental cause. However, religious life among the society does not necessarily mean conflict or religious differences is not identical with conflict. Research conducted 2012 in Colo Village, Dawe, Kudus, Central Java shows that people from different religious background has created harmony among themselves. This research uses observation and interview to collect data from the research field and applies descriptive qualitative analysis. In 2012 the population in Colo is 4.327 people consisting of 2.400 family in which the majority are Moslem. There are also 16 Christians, 40 Buddhists and 14 Ahmadiyahs family living in one village. All religious adherents build their own sacred places consisting of five mosques (the Muria Mosque in Muria Mountain built by the Central Java Provincial government, two mosques in Colo village and a mosque built by Ahmady people, 11 mushalla (Muslim prayer house spread in four hamlet of Colo, a church beside a vihara. The vihara was built during Gus Durs presidency. In addition, there are two private Islamic schools, two elementary schools, a private junior Islamic high school (MTs, a private senior Islamic high school (MA, three Quranic learning centers, a kindergarten and an Islamic playgroup. Religious harmony among the society in Colo is established through

  7. Study on curing reaction of 4-aminophenoxyphthalonitrile/bisphthalonitrile

    Institute of Scientific and Technical Information of China (English)

    Xiao

    2010-01-01

    A series of phthalonitrile blending resins were prepared from 4-aminophenoxyphthalonitrile (APN) and 4,4'-bis (3,4-dicyanophenoxy)biphenyl (BPH) by directly powder-mixing and copolymerization. Differential scanning calorimeter (DSC) and dynamic rheology were used to study the curing reaction behaviors of APN/BPH blends, and the results indicated that the introduction of APN accelerated the curing rate of BPH, and the existence of BPH decreased the curing temperature of APN/BPH systems. The thermal stability of postcured APN/BPH resins was investigated by thermogravimetric analysis (TGA), and the TGA results indicated that the crosslinked polymers of APN/BPH systems possessed good thermal stability.

  8. Cystatin C–Adiponectin Complex in Plasma Associates with Coronary Plaque Instability

    Science.gov (United States)

    Matsuoka, Tetsuro; Kayama, Kento; Onishi, Sumire; Matsuo, Natsumi

    2017-01-01

    Aim: Adiponectin (APN) is an adipocyte-derived bioactive molecule with antiatherogenic properties. We previously reported that cystatin C (CysC) abolished the anti-atherogenic effects of APN. We aimed to elucidate the clinical significance of CysC–APN complex in patients with coronary artery disease (CAD). Methods: We enrolled 43 stable CAD male patients to examine the relationship between CysC–APN complex and coronary plaque characteristics. Serum was immunoprecipitated by the anti-APN antibody and immunoblotted by the anti-CysC antibody to demonstrate the presence of CysC–APN complexes in vivo. To confirm their binding in vitro, HEK293T cell lysates overexpressing myc-APN and FLAG-CysC were immunoprecipitated with an anti-myc or anti-FLAG antibody, followed by immunoblotting with an anti-APN or anti-CysC antibody. Results: CysC was identified as a specific co-immunoprecipitant with APN by the anti-APN antibody in human serum. In vitro, FLAG-CysC was co-immunoprecipitated with myc-APN by the antimyc antibody and myc-APN was co-immunoprecipitated with FLAG-CysC by the anti-FLAG antibody. Among CAD patients, serum CysC–APN complex levels negatively correlated with fibrotic components of coronary plaques and positively correlated with either necrotic or lipidic plus necrotic components. Plaque burden negatively correlated with serum APN levels but not serum CysC–APN complex levels. Serum CysC levels had no association with plaque characteristics. In multivariate analysis, CysC–APN complex levels were identified as the strongest negative factor for fibrotic components and the strongest positive factor for both necrotic and lipidic plus necrotic components. Conclusion: Measuring serum CysC–APN complex levels is helpful for evaluating coronary plaque instability in CAD patients. PMID:28321013

  9. PEMAHAMAN MASYARAKAT KECAMATAN MERGANGSAN, GONDOKUSUMAN, UMBULHARJO DAN KOTAGEDE YOGYAKARTA TERKAIT ANTIBIOTIKA Studi Pendahuluan Dalam Pengembangan Materi dan Metode Edukasi Dengan Pendekatan Secara Kualitatif: Diskusi Kelompok Terarah (DKT

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    Titien Siwi Hartayu

    2016-04-01

    Full Text Available Abstract: Antibiotics will be used safely when it is used rationally, and rational use of antibiotics need an appropriately of knowledge. In accordance to achieve appropriately knowledge about antibiotics, it is important to identify the level of knowledge about antibiotics to improve an educational method and material about antibiotics. As a qualitative study using focus group discussion (FGD among residence of Four Sub-district in Yogyakarta City, e.g.: Mergangsan, Gondokusuman, Umbulhardjo and Kotagede. There was eight key person of each sub district involved in the study. The inclusion criteria are: Residence of one of the four sub-districts with age above 17 years old, willing to attend the activities. The exclusion criteria are: residence with Pharmacy education background, moving limited and mental disability. Results of the study show the characteristic demography of the participants are: 5 Female and 3 Male, age range from 40 to 52 years old, with educational level: 5 participants are high school graduated and 3 participants are University graduated. All of participants are key person of each sub district whose familiar with the residences and the environmental where they are living. All of participants mention that they do not know about antibiotics et all including resistance and other risks of irrational use of antibiotics. All of participants asking for complete information about antibiotics which simple, accessible and could be socialized through the routine activities in every sub district e.g.: PKK (mothers gathering. In conclusion, the level of participants' knowledge about antibiotics is still low, and need to be improved. Complete information about antibiotics in a simple form has to be developed as an educational material. Keywords: Focus Group Discussion, Antibiotics, Knowledge

  10. Uji Daya Hambat Jamur Endofit dan Eksofit dalam Menekan Pertumbuhan Fusarium oxysporum f.sp. vanillae Penyebab Busuk Batang Panili Secara In Vitro

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    NI WAYAN SUNITI

    2016-11-01

    Full Text Available Study on In Vitro Inhibitory Ability of Endophytic and Exophytic Fungusin Suppressing the Growth of Fusarium oxysporum f.sp. vanillae thatCauses Stem Rot of Vanilla. Vanilla stem rot disease caused by Fusarium oxysporumf.sp. vanillae , is still a very dangerous disease and feared by vanilla farmers. Disease until thepresent time there does not yet appear adequate control strategies for the disease. On the basisof these problems interested studied the use of endophytic fungi and exophytic existing on theleaves and stems of healthy plants , which have potential as a biological agent to controlpathogens . The study was conducted in three stages: (1 isolation of the pathogen and fungalendophyte and exophytic, (2 identification of pathogenic microscopic morphology, fungalendophyte and exophytic, and (3 test the inhibition of fungal endophyte and exophyticagainst pathogens. Fungi are found as the leaves are Aspergillus niger and Rhizopus spp., Onexophytic on the trunk is Trichoderma sp . and Fusarium spp., as a leaf endophytic found A.niger and Neurospora spp. and as endophytic rod is Neurospora spp . The highest prevalenceachieved by Neurospora spp . which is equal to 100 % on endophyte stem, while Rhizopusspp., and Fusarium spp. by 90 % respectively, exophytic on the leaves and stems. The testresults found that the inhibition of leaf eksofit Rhisopus spp . give up inhibition ranged from70.37±3.2% - 100% , while A. niger amounted to 72.22% . In exophytic on rod found onlyTrichoderma sp. inhibit pathogens by 73.70±3.57%. In endophytic on leaf found A. niger at70.37±3.2% , while Neorospora spp. ranging from 79.11±3.21% - 88.50±2.10%. In theendophytic on trunk was found Neurosporas spp. amounting to 70.74±3.57% - 79.26±1.28%.

  11. Pertanggungjawaban Pidana Pekerja Seks Komersial Dalam Tindak Pidana Prostitusi Secara Online Berdasarkan Undang Undang Nomor 11 Tahun 2008 Tentang Informasi Dan Transaksi Elektronik Di Polresta Pekanbaru

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    Maulidya, Risgaluh; Effendi, Erdianto; ', Erdiansyah

    2016-01-01

    Arrangements regarding the prohibition of online prostitution has beenformulated clearly in positive law but law enforcement in this case is very difficultto do. This is due to the difficulty of determining the jurisdiction of prostitutiononline criminal act in Indonesia, especially in Pekanbaru become a seriousproblem currently faced. Therefore online prostitution should be addressed in arational way. One rational efforts is with law enforcement policies. The purposeofthis study are to know ...

  12. Perbandingan Ko-kultur 2D dan 3D dengan Metode Hanging Drop untuk Menghasilkan Micro-environment yang Lebih Relevan Secara Klinis

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    Radiana Dhewayani Antarianto

    2017-09-01

    Full Text Available Ko-kultur sel 2 dimensi (2D kurang menyerupai micro-environment seperti in vivo sedangkan ko-kultur 3 dimensi (3D membentuk mikromassa yang lebih mirip micro-environment in vivo sehingga bermanfaat dalam penelitian biologi dasar. Penelitian ini membandingkan ko-kultur 2D dan 3D sel punca serta sel stelata hepatik dengan metode hanging drop untuk menilai morfologi sel dan pembentukan sferoid dari mikromassa yang terbentuk. Studi in vitro ini dilakukan di Pusat Virologi dan Kanker Patobiologi (PRVKP UI dan laboratorium histologi FKUI pada bulan September 2015 sampai Oktober 2016 menggunakan sel punca yang diisolasi dari darah tali pusat manusia dan sel lestari LX2 (stelata hepatik manusia. Darah tali pusat disortir dengan MACS CD34 dan dianalisis flowcytometry. Ko-kultur sel punca sumsum tulang atau darah tali pusat dan LX2 dilakukan dengan metode hanging drop untuk ko-kultur 2D dan ko-kultur 3D. Triplikasi eksperimen dilakukan untuk tiap set ko-kultur. Hasilnya menunjukkan terdapat perbedaan morfologi ko-kultur 2D dan 3D hanging drop dibandingkan monokultur. Di ko-kultur 2D terdapat mikromassa dan di monokultur 2D tidak terbentuk mikromassa. Di ko-kultur 3D hanging drop, terdapat sferoid yang lebih kecil dibandingkan monokultur 3D hanging drop. Morfologi sel ko-kultur 2D dan 3D dengan metode hanging drop dibandingkan monokultur menunjukkan perubahan fenotip sel-sel yang tergabung dalam mikromassa. Normal 0 false false false false IN X-NONE X-NONE Normal 0 false false false false IN X-NONE X-NONE KARAKTERISASI DAUN MIANA (Plectranthus scutellarioides (L. Bth. DAN BUAH SIRIH (Piper betle L. SECARA FISIKO KIMIA DARI RAMUAN LOKAL ANTIMALARIA DAERAH SULAWESI UTARA

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    Vivi Lisdawati

    2012-10-01

    Full Text Available Multidrug-resistant Plasmodium falciparum strains are an increasing problem in endemic areas and are partly responsible for the worsening malaria situation around the world. New cheap and efftctive compounds active in combination with available drug in the field, such as indegenous traditional medicine, are urgently needed. The aim of this work was to characterize the simplitia and extracts of an indegenous traditional medicine which usually used in North Sulawesi. Since this indigenous traditional medicine has been largely used and well-tolerated in humans, secondary metabolites derivatives of the plants could be in the near future associated with already available drugs in order to delay the spread of P. falciparum resistance. Non polar, semi polar and polar extracts of P. scutellarioides folium and P. bette fruit are prepared of each plants part obtained, then evaluated by using chromatography and densitometry methods following identification.   Keywords: P. falciparum, antimalarial activity, P. scutellarioides folium, P. betle fruit, secondary metabolites

  13. Pengujian validasi analisis kadar andrografolid secara kromatografi cair kinerja tinggi (KCKT dengan eluasi gradien terhadap ekstrak herba sambiloto (Andrographis panuculata Ness

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    Toetik Aryani

    2012-02-01

    Full Text Available Andrographolide of Andrographis paniculata Nees have been isolated and determined Extraction was carried out by maceration with ethanol as solvent. The concentration of Andrographolide was determined by HPLC method.The eluation was carried by out gradiently using methanol: water as an eluent and UV spectrophotometer at maks 228 as detector. The result of HPLC analysis are selectivity >1.2–1.5; r was 0.9937; precision was KV 90%; DL was 0.075; QL was 0.50 and PW < F table. Andrographolide content of Andrographis paniculata Nees from Banyuwangi was 6.25%, Kediri was 14.69% and Surabaya was 6.83%

  14. Penetapan Kadar Campuran Isoniazid dan Vitamin B6 dalam Sediaan Tablet Campuran Etambutol, Isoniazid dan Vitamin B6 Secara Spektrofotometri Derivatif dengan Metode Zero Crossing

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    Daulay, Elisa Fitri

    2016-01-01

    The compound of isoniazid and pyridoxine hydrochloride is one of combination in tablet. Determination of content of isoniazid and pyridoxine hydrochloride in tablet where not found in monography, either in the fourth edition Farmakope Indonesia (1995) or USP (United States Pharmacopeia) 30th edition (2007) that requires an analysis method that meets the test of validity in determining the content. The purpose of this research is to determine isoniazid and pyridoxine hydrochloride mixture us...

  15. PENGUSAHAAN TERUMBU KARANG SECARA BERKELANJUTAN (Studi Kasus Perubahan Usaha Terumbu Karang Alam ke Budidaya Terumbu Karang di Pulau Serangan, Kccamatan Denpasar Selatan, Kota Denpasar-Bali

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    ARSONETRI ARSONETRI

    2015-05-01

    Full Text Available Illegal coral extraction (taking coral from nature as an unsustainable effort affected the degradation of coral reef ecosystem and coastal environment. However, 1t continually happens in Indones1a, particularly in Scr,rngan Island, Bali. The stakeholder in coral extraction effort have gamed good advantages (benefits making a legally and sustainable clTort such as coral culture still difficult. This study 1s specifically examines the methods of coral culture 1s better and profitable than the methods of coral extraction from nature. Thus, encouragmg all parlles involved (stakeholder, especially fishem1an to apply the coral culture. The research is observed and compared between coral extraction from nature fisherman and coral culture fisherman in Serangan Island, the feasibility, benefits and fisherman's perception. It is also explain the role of government toward of coral extraction and culture. 1he result shows the benefit or advantage of coral culture is higher than coral extraction from nature. It demonstrated by NPV (Net Present Value and CBR (Cost Benefit Ratio of coral culture is higher than coral extraction from nature. Therefore, coral culture is economically feasible to replace coral extraction from nature. The fisherman's perception is very pos1llve regarding coral culture effort and implementation replacing coral extraction from nature. In this effort, the government's role is very important in provision mcentive such as modal and subs1d1es, trainings and increasing fisherman capacity building, market insurance, and easier to obtain permits of coral culture.

  16. Uji Daya Hambat Sabun Cair Cuci Tangan pada Restoran Waralaba di Kota Padang Terhadap Pertumbuhan Bakteri Escherichia coli dan Staphylococcus aureus Secara In Vitro

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    Anisha Fazlisia

    2014-09-01

    Full Text Available AbstrakSabun cair cuci tangan terbukti dapat menghambat pertumbuhan bakteri Escherichia coli dan Staphylococcus aureus. Sebagian besar restoran waralaba di Kota Padang menyediakan sabun cair cuci tangan yang telah diencerkan. Proses pengenceran mengubah kemampuan sabun dalam menghambat pertumbuhan bakteri. Penelitian bertujuan untuk menguji daya hambat sabun cair cuci tangan pada restoran waralaba di Kota Padang terhadap pertumbuhan E. coli dan S. aureus. Sampel diambil dari empat restoran waralaba dan diuji dengan metode difusi. Hasil penelitian menunjukkan bahwa keempat sabun dapat menghambat pertumbuhan S. aureus namun hanya sebagian yang memiliki daya hambat terhadap E. coli. Median daya hambat pertumbuhan E. coli dan S. aureus pada setiap periode yaitu 0, 7.4, 7.3 dan 0, 26.1, 23.3. Nilai maksimum daya hambat pertumbuhan E.coli dalam tiga periode yaitu 19.5, 35.4, 27.1 dan 20.7, 40.2, 36.6 untukS. aureus. Daya hambat minimum terhadap kedua bakteri adalah 0.00. Hal tersebut dapat dipengaruhi komposisi dan konsentrasi antiseptik, antibakteri, pH sabun, pengenceran dan struktur dinding sel bakteri. Disimpulkan bahwa sabun cair cuci tangan yang diuji memiliki kemampuan lebih besar dalam menghambat pertumbuhan S.aureus daripada E.coli.Kata kunci: sabun cair cuci tangan, restoran, pengenceran, uji daya hambat, pertumbuhan bakteriAbstractLiquid hand soaps proved to inhibit Escherichia coli and Staphylococcus aureus bacterial growth. In Padang, most of Restaurants provide diluted liquid hand soaps. Research found dilution changed soap ability to inhibit bacterial growth. The purpose of this study was to examine the ability of Padang City Restaurants’ liquid hand soaps to inhibit E. coli and S. aureus bacterial growth. The samples were taken from four restaurants and examined by using diffusion method. The results showed all of them could inhibit S. aureus but only a half inhibited Escherichia coli bacterial growth. Median for E. coli and S. aureus bacterial inhibition growth for each period were 0, 7.4, 7.3 and 0, 26.1, 23.3. Maximum inhibition value for E. coli growth in the first, second, and third periods were 19.5, 35.4, 27.1 and 20.7, 40.2, and 36.6 for S. aureus. In addition, minimum inhibition in both bacteria were 0.00. It could be influenced by soap antiseptic and antibacterial composition and concentration, pH, dilution, and structure of bacterial cell wall. In conclusion, the liquid hand soaps has greater ability to inhibit S. aureus than E. coli.Keywords: liquid hand soaps, restaurant, dilution, inhibitory test, bacterial growth

  17. STUDI PEMETAAN AWAL DNA Mycobacterium tuberculosis COMPLEX SECARA Spoligotyping PADA HASIL ISOLASI DAHAK PASIEN TUBERKULOSIS PARU DARI 10 IBU KOTA PROPINSI (BAGIAN I

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    Vivi Lisdawati

    2012-08-01

    Full Text Available Abstract. Mapping TB genotype of Mycobacterium tuberculosis (Mtb is an important study to identify their distribution or characteristic and also may lead to improve control of the disease. This study conducted a preliminary mapping of the tubercle bacilli which had been circulating in Indonesia. Cultures of DNA isolated from TB patients at urban areas in 16 provinces in Indonesia, are chosen based on TB Case Detection Rate (CDR 2006 from Indonesia Directorate General of Communicable Disease Control and Environment Health (Ministry of Health, were analyzed by spoligotyping for strain differentiation. In this first part, the analyzed result only came from urban areas in 10 provinces, i.e. Palembang, Bandar Lampung, Serang, Jakarta, Bandung, Surabaya, Banjarmasin, Makassar, Pontianak and Ambon. Sample were 269 DNA from 294 isolates collected from sputum of suspect TB patients with sputum-smear positive (SS+ and age above 15 years old. All samples were obtained from peripheral health laboratory in each province. The procedure collection is accordance to Indonesia DOTs guidelines (AFB smears and samples were transported from those 10 areas to Bacteriology Laboratory at CBPRD. Sputum was taken for culture in liquid media MGIT Bactec 960 and solid media Lowenstein Jensen. The DNAs from positive liquid media MGIT Bactec 960 were isolated and analyzed by spoligotyping to identify the spoligo pattern. The spoligotyping results converted into octal format within Words & Excel spreadsheets and compared to International Spoligotype-database (SpolDB4. The previous study (Parwati et.al. found some differences geographical distribution between Beijing genotype strain of tubercle bacilli in West Indonesia compare to East Indonesia, and the same pattern was also found in this study. Furthermore, the results in this study showed the differences in spoligo pattern of Mtb complex at 10 urban areas in West, Middle and East Indonesia. The percentage of Beijing strain family in the samples from West Indonesia showed around 26.61% (31.48% in Sumatra, 28.83% in Java and 16.98% in Kalimantan; from the Middle Indonesia around 25.93%; and none were found in samples from the East Indonesia. The SpolDB4 pattern also showed that the majority of isolates belonged to major clades of M.tuberculosis, i.e. the East African-Indian (EAI; Haarlem (H, Latin American-Mediterranean (LAM, the Central and Middle Eastern Asian (CAS; U = undefined; T = T family; and the MANU/ Manu family. We also found some isolates of Mycobacterium bovis. There were no significant association showed between genotype families and gender, but strong significant association found with ethnics and geography. Further confirmation of the results is still ongoing (k value; RFLP and MIRU-VNTR. As conclusion, this study constituted a first attempt to describe the preliminary mapping of genetic population structure of the tubercle bacilli circulating in Indonesia.   Key words: preliminary mapping, Mtb complex, spoligotyping, Beijing genotype strain, SpolDB4

  18. HIDROLISIS IKAN BERNILAI EKONOMI RENDAH SECARA ENZIMATIS MENGGUNAKAN PROTEASE BIDURI [Enzymatic Hydrolysis of Low Economic Value Fishes using Biduri’s Protease

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    Yuli Witono1*

    2015-07-01

    Full Text Available Fish protein hydrolyzate is a product obtained from the decomposition of fish proteins into short-chain compounds due to the hydrolysis process either by enzymes, acids, or bases. The purpose of this study was to optimize the production of fish protein hydrolyzate from the low economic value fishes including 'bibisan' (Apogon albimaculosus, 'baji-baji' (Platycephalidae cymbacephalus, and the 'lidah' (Cynoglossus lingua obtained from Talango Island, Madura. Production of fish protein hydrolyzate was conducted using (Calotropis gigantea protease at various concentrations (0, 0.7, 1.4, and 2.1 Unit/g and at various hydrolysis times (0, 1.5, and 3 h. The experimental design was a Completely Randomized Design with two factors and the experiments were carried out in triplicates. The results showed that interactions between protease concentrations and hydrolysis times significantly affected (at 5% level test the soluble proteins, maillard products, and the level of rancidity measured as thiobarbituric acid (TBA. The best fish hydrolyzate product based on the soluble protein parameter was resulted from 2.1 unit/g of biduri’s protease with a hydrolysis time of 1.5 h. The hydrolyzate produced had 3.51% of soluble proteins, a maillard value of 0.63, and rancidity levels of 12.21 mmol TBA/kg.

  19. Phenotypic and Serotypic Characterization of Staphylococcus aureus Strains from Subclinical Mastitis Cattle (KARAKTERISASI SECARA FENOTIPE DAN SEROTIPE STAPHYLOCOCCUS AUREUS YANG BERASAL DARI MASTITIS SUBKLINIK PADA SAPI

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    Siti Gusti Ningrum

    2016-07-01

    Full Text Available Staphylococcus aureus is known as a major causative agent of mastitis in dairy cattle. In the presentstudy, 104 isolates of Staphylococcus originated from subclinical mastitis cattle characterized for thephenotypic properties and the presence of Staphylococcal protein A (Spa. Some bacteria were resistancesagainst several antibiotics were also studied, such as erythromycin, streptomycin, tetracycline, cefepime,nitrofurantoin, amikacin, chloramphenicol, and ciprofloxacin. About 78% of the isolated were moderatelysensitive to nitrofurantoin, while 89% were highly resistant to cefepime and ciprofloxacin. Using thevarious mammals’ sera, seven isolates out of 104 revealed the presence of Spa.

  1. PEMECAHAN DORMANSI DAN PERKECAMBAHAN ASAM KURANJI (Dialium indum L. SECARA MEKANIS DAN KIMIAWI Breaking Dormancy and Seeds Germination of Asam Kuranji (Dialium indum L. with Mechanical and Chemical

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    Bakti Nur Ismuhajaroh

    2016-08-01

    Full Text Available The purpose of the study was to find out the dormancy breaking and the seed germination of Asam kuranji (Dialium indum L. mechanically by sandpapering the seeds and chemically by immersing them in sulfuric acid (H2SO4. The experiment was conducted at the Plant Physiology Laboratory of Agricultural Faculty of Lambung Mangkurat University from June - August 2013 using Completely Randomized Design (CRD with 2 x 4 factorial. The first factor was the mechanical treatment  (s0 = without sandpaper and s1 = with sandpaper, the second factor was the chemical treatment (a0 = without immersion, a1 = 70% of H2SO4, a2 = 80% of H2SO4, and a3 = 90% of H2SO4. The data were analyzed by ANOVA at the level of 95% followed by Tukey's test at the level test of 95%. The results showed that the treatments of sandpapering and immersing the seeds significantly affected the % of germination, the length of radicle and the length of hypocotyl. The interaction between treatments of sandpapering and immersion indicated that the higher the concentration of H2SO4 immersion the higher the % of germination, the length of radicle and the length of hypocotyl. Keywords: germination, Dialium indum L., sandpaper, concentration, H2SO4

  2. AKTIVITAS KOMBINASI EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L. DAN DAUN PEGAGAN (Centella asiatica L.Urb TERHADAP KELARUTAN KALSIUM BATU GINJAL SECARA IN VITRO

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    Ni Wayan Swintari

    2017-03-01

    Full Text Available Soursop (Annona muricata L. and gotu kola (Centella asiatica L.Urb is a plant that can be used as a laxative medicine kidney stones. This is because of the content of bioactive compounds including flavonoids, especially the leaf section. The use of a combination of soursop leaf extract and gotu kola can improve their effectiveness in order to remove calcium kidney stones. Therefore, this study aims to determine the activity and to determine dose combination soursop leaf ethanol extract (SS and gotu kola leaf (GK which is effective for dissolving potassium kidney stones. Extracts prepared by maceration method using ethanol 96% then subsequently tested phytochemical screening and thin layer chromatography profiles on each extract. Results chromatogram showed the extract containing flavonoids. Testing the activity of the combination of soursop and gotu kola extract performed using seven treatments, combination 1 (SS 1% + GK 7.5% , a combination of 2 (SS  0.5% + GK 3.75%, the combination of 3 (SS 0, 25% + GK 1.875%, single soursop leaf extract (1%, single gotu kola extract (7.5%, negative control (aquadest and positive control (Batugin elixir. Kidney stones are then put as much as 100 mg in each treatment and incubated for 6 hours (37 ℃. Results filtrate then didestruksi and dissolved calcium levels measured using Atomic Absorption Spectrophotometer. The results showed the combination soursop leaf ethanol extract and gotu kola leaf extract with a combination of 2 (SS 0.5% + GK 3.75% is an effective combination of the ability to dissolve calcium kidney stones in vitro.

  3. Pemanfaatan Tithonia Diversifolia pada Tanah Sawah yang Dipupuk P Secara Starter terhadap Produksi serta Serapan Hara N, P, dan K Tanaman Padi

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    Gusnidar

    2008-09-01

    Full Text Available The research of Tithonia diversifolia utilization in the paddy soil that was fertilized P-starter on yield and N, P, K uptake on rice crop, has been conducted from August to December 2005. The objective of this research was to determine an interaction between P-starter levels, and tithonia levels on production and N, P, K element uptake of rice crop. The research was pot experiment in the green house in factorial design 4 x 4. First factor was 4 levels of tithonia with reduce dosage fertilizer applied (T0 = 0 t ha-1 of tithonia + 200 kg ha-1 of urea + 75 kg ha-1 of KCl ; T1= 2,5 t ha-1 of tithonia+ 150 kg ha-1 of urea , without KCl; T2 = 5,0 ton ha-1 of tithonia+ 100 kg ha-1 of urea , without KCl; dan T3 = 7,5 t ha-1 of tithonia + 50 kg ha-1 of urea, without KCl. The second factor was 4 levels of P-starter (0, 2, 4, and 6 kg P ha-1. The result showed that combination of T3 treatment and 2-4 kg P-starter ha-1 increased the grain yield 20,51-21,08 g pot-1 (18,65-19,21 %. Effect of T3 treatment was not significantly differences with T2 treatment on the grain yield. The best interaction was T3 treatment on N and K uptake (0,84 g pot-1 for N, dan 0,82 g pot-1 for K.

  4. Penyebaran Penyakit Rabies pada Hewan Secara Spasial di Bali pada Tahun 2008-2011 (THE SPATIAL DISTRIBUTION OF RABID ANIMAL IN BALI DURING 2008-2011

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    I Wayan Batan

    2014-08-01

    Full Text Available Rabies is a new emerging disease in Bali. The first rabies case was reported in October 2008 atKedonganan and Jimbaran village, District of South Kuta, Badung regency. The rabies diseasehas now been distributed to all areas of Bali causing death of more than a hundred of human beingand thousands of dogs. The aim of the studies was to make a map of rabies distribution in Balibased on cases in animals (dog and Bali cattle and human. The research was conducted bymaking a field surveys in nine regency of Bali. The surveys were focused on the occurrence ofhuman and animal rabies at the village level. The open ended questionaire was used in this surveyto collect data, and the secondary data also used in this study. Based on rabies disease mapping,it showed that the rabies have been distributed to eight regency and one city, covered 281 villagesout of 722 villages in Bali. In conclusion, the rabies had been distributed to all parts of Bali in threeyears periods.

  5. ZONASI PERIKANAN PASI UNTUK KEPENTINGAN PEMANFAATAN SECARA BERKELANJUTAN SUMBERDAYA IKAN KAKAP MERAH DI KEPULAUAN LEASE (Pasi Zone for Interest Sustainable Utilization of Red Snapper Resources in Lease Islands

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    Delly Dominggas Paulina Matrutty

    2015-01-01

    Full Text Available ABSTRAK Pasi adalah daerah penangkapan spesifik ikan kakap merah di Kepulauan Lease. Eksploitasi terhadap sumberdaya ikan kakap merah cenderung tinggi akhir-akhir ini karena sangat disukai di pasar lokal, regional maupun internasional, selain dijadikan sebagai objek wisata pancing. Kondisi ini akan mengancam kelestarian sumberdaya jika tidak dikelola dengan baik. Penetapan zonasi merupakan salah satu alternatif pengelolaan sumberdaya perikanan yang baik, dan jika dilakukan dengan benar akan memberikan nilai tambah bagi masyarakat, tanpa mengganggu kelestariannya. Tujuan penelitian ini adalah menentukan zonasi perikanan pasi untuk kepentingan pemanfaatan berkelanjutan sumberdaya ikan kakap merah di Kepulauan Lease. Data yang digunakan meliputi hasil kajian potensi sumberdaya ikan kakap merah, kondisi oseanografi  daerah penangkapan (pasi, dan sistem nilai perikanan pasi yang meliputi komponen nilai dasar ekologi, sosial dan teknologi, serta metode Participatory Rural Appraisal (PRA.  Berdasarkan kriteria yang dibangun dari seluruh aspek tersebut  maka dibuat zonasi khusus untuk kawasan pasi di Kepulauan Lease.  Berdasarkan hasil  analisis  diperoleh 4 (empat dari  25  pasi  ditetapkan sebagai zona lindung, 21 pasi ditetapkan sebagai zona perikanan berkelanjutan sub-zona perikanan tangkap, sedangkan 13 di antaranya ditetapkan sebagai zona pemanfaatan sub-zona wisata pancing. ABSTRACT Pasi is a specific fishing ground for Red Snapper in Lease Islands.  Recently, the exploitation of the red snapper population is tend to increase due to high demand of local, regional and international market as well as object for fishing tourism. This condition will threat the sustainability of the resources as if it is unmanaged in good way.  Zone determination is one of the alternatives of good fisheries resources management. If it is done in a right way, it will add value to community without disturbing the sustainability. The objectives of the present study were to determine fisheries pasi zone to the sustainability importance of red snapper resources in Lease Islands.  Data used included study of potential of red snapper resources, oceanographically condition, fishing ground (pasi, and fisheries value system namely basic value of ecological component, social and technology as well as PRA method (Participatory Rural Appraisal.  Based on the criteria which were formulated of all aspects, specific zonation was made for pasi region in Lease Islands.  The analysis showed that there were 4  out of 25 pasi determined as shelter zone, 21 pasi was for sustainable fisheries zone sub-zone of catch whereas 13 pasi was determined as utilization zone sub-zone fishing tourism.

  6. Pengaruh Konsentrasi Ekstrak Etanol Daun Jamblang (Syzygium cumini(L.) Skeels) dan Amylum Oryzae Terhadap Nilai Sun Protection Factor Krim Tabir Surya Oktil Metoksisinamat secara In Vitro

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    Zakaria, Sri Rahmayanti Azhar

    2016-01-01

    Sun exposure contain ultraviolet radiation that can cause a variety of skin disorders ranging from reddish, black spots, dryness, wrinkles to skin cancer. Cosmetic sunscreen can filter the sun or hold the entire sun exposure to reduce the adverse effects of sunlight. Octyl methoxycinnamate (OMC) is an active substance which works chemically to absorb ultraviolet light (UV) into the epidermal layer of the skin. Another active subtance is a jamblang leaf (Syzigium cumini (L) Skeels) because it ...

  7. PENGUJIAN SIFAT PREBIOTIK DAN SINBIOTIK PRODUK OLAHAN UBI JALAR SECARA IN VIVO [In Vivo Evaluation of Prebiotic and Synbiotic Properties of Processed Sweet Potato Products

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    Lilis Nuraida1,2

    2008-12-01

    Full Text Available The aims of this research were to investigate the prebiotic and synbiotic properties of sweet potato products (combined with L. casei subsp Rhamnosus for probiotic in increasing the number of Lactic Acid Bacteria (LAB and suppressing the number of E. coli and the occurrence of Salmonella in vivo. Some previous study showed that sweet potato is a potent source of prebiotic. The sweet potato products evaluated were sweet potato flakes (SPF and sweet potato ice cream mix. The in vivo assay used male rat strain Sprague-Dawley. Total microbes, LAB, E. coli and Salmonella in fecal were analyzed before, during and after feeding period. Feeding with SPF as prebiotic, L. casei subsp Rhamnosus as probiotic, and combination of both as synbiotic for ten days were able to increase the number of LAB (0.4-1.1 log CFU/g and suppress the number of E. coli in rat feces (1.5-1.7 log CFU/g. All of the treatment did not affect the occurrence of Salmonella in rat feces. The treatment of sweet potato ice cream mix as prebiotics and the combination of sweet potato ice cream mix and L. casei subsp. Rhamnosus as synbiotic for ten days did not effect the number of LAB and E. coli in rat feces.

  8. Penentuan Secara Imunopatologi Organ Target Virus Flu Burung Menggunakan Streptavidin Biotin (DETERMINATION OF TARGET ORGANS OF AVIAN INFLUENZA VIRUS USING IMMUNOPATHOLOGICAL IMMUNOHISTOCHEMISTRY STREPTAVIDIN-BIOTIN

    Directory of Open Access Journals (Sweden)

    Niken Yunita

    2018-01-01

    Full Text Available Avian influenza is a viral disease in poultry caused by avian influenza virus (AIV subtype H5N1 with varying clinical signs are often similar to the clinical signs of other viral infections, such as Newcastle disease virus (NDV. The mechanism of disease pathogenesis to express clinical signs tightly correlated to the determination of the target organ seen from AIV H5N1 antigens distribution in organs, such as respiratory tract, brain and gastrointestinal tract. Immunopathological immunohistochemistry streptavidin-biotin (IHC SB is a method for sensitive and accurate in detecting antigens of AIV on the tissues. In the present study, it was determined whether in laying hens with clinical signs of torticollis and curled toe paralysis, and pathologic anatomic lesions in the form of petechial and foci necrotic hemorrhages tested with immunopathological IHC SB is positive AIV H5N1 infection. IHC SB study results showed that the AIV H5N1 antigen were found in tissues of the lung, brain, duodenum and proventriculus. Based on these results, we can conclude that the IHC SB is a method that is highly sensitive and accurate to detect H5N1 antigens and its distribution in the host.

  9. ANALISIS ASPEK ERGONOMI PEKERJA BAGIAN SORTASI AKHIRPADA PENGOLAHAN KOPI ROBUSTA SECARA SEMI BASAH (Studi Kasus PT. J. A. Wattie Perkebunan Durjo Jember

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    Andrew Setiawan R

    2016-11-01

    Full Text Available The research objective  is evaluating the convenience of the sorting condition in terms of aspects concerning the use of anthropometry include the comfort of a chair, to evaluate the working environment (temperature and humidity of the room work as well as noise and provide an alternative design of chairs and tables by the method of anthropometry. This research used 30 respondents who had been sampled. The research was limited to observations of temperature, humidity, noise and anthropometric include seat height, height shoulders, wide hips, knee height, popliteal height, buttock - popliteal, shoulder width, height and arm reach. The results showed that the temperature and humidity of the room was still not optimal noise intensity as well as some parts of the production of more than Limit Value. Subjective complaints occurred in almost all parts of the body of workers. Complaints caused by the design of chairs and tables that are less ergonomic and environmental conditions are less than optimal. The size of the table after redesigning the table height 80 cm, width 70 cm and length of the table table 195 cm while the size of a chair after redesigning the high chair (without backrest 46 cm, 100 cm wide backrest and cushion length and 120 cm high backrest by 54 cm. Alternative solution given is to redesign the tables and chairs based on data antropomerti workers so as to create a means by which ergonomic and improvement of environmental conditions.

  10. Klausula Terkait Perlindungan Terhadap Buruh Migran Dan Urgensinya Untuk Diatur Secara Khusus Di Dalam Perjanjian Perdagangan Bebas Antara ASEAN Dan Uni Eropa

    OpenAIRE

    Nur Heriyanto, Dodik Setiawan

    2015-01-01

    Economic globalization encourages some individuals to move abroad for a better living and livelihod. Currently, it is undeniable that the existence of foreign migrant workers can support the economic sutainability of European Union. However, foreign migrant workers mostly coming from ASEAN countries are only provided with limited social protection. Therefore, the research problems of this study are, first, whether the European Union rules have provided social protection for foreign migrant wo...

  11. Klausula Terkait Perlindungan terhadap Buruh Migran dan Urgensinya untuk Diatur Secara Khusus di dalam Perjanjian Perdagangan Bebas antara ASEAN dan Uni Eropa

    OpenAIRE

    Nur Heriyanto, Dodik Setiawan

    2017-01-01

    Economic globalization encourages some individuals to move abroad for a better living and livelihod. Currently, it is undeniable that the existence of foreign migrant workers can support the economic sutainability of European Union. However, foreign migrant workers mostly coming from ASEAN countries are only provided with limited social protection. Therefore, the research problems of this study are, first, whether the European Union rules have provided social protection for foreign migrant wo...

  12. Pengaruh Tes Elevasi Tungkai Secara Pasif terhadap Variasi Pletismograf untuk Penilaian Responsivitas Cairan pada Pasien yang Dilakukan Pembedahan dengan Anestesi Umum

    Directory of Open Access Journals (Sweden)

    Bahtiar Susanto

    2016-08-01

    Full Text Available Fluid responsiveness assessments have shown to be an important matter in perioperative fluid optimization. Respiratory variations in pulse oximetry plethysmographic waveform amplitude (∆POP and passive leg raising have been shown as promising indicators due to the ability to predict fluid responsiveness. The aim of this study was to assess the effect of passive leg raising (PLR on ∆POP to predict fluid responsiveness in mechanically ventilated patients after induction of general anesthesia. This was a trialon 30 patients referred for surgery under general anesthesia, aged 18–60 years and ASA physical status I or II, during the period of February–March 2015 at the Central Surgical Installation of Dr. Hasan Sadikin General Hospital Bandung. Patients were studied immediately after the induction of general anesthesia. This trial use the paired t test, Wilcoxon test, and ANOVA for statistical analysis. Vital signs and ∆POP were recorded at baseline, before, and after PLR. PLR induced changes in ∆POP with a ∆POP greater than 13% compared to the initial PLR allowed discrimination between responders and nonresponders to 6/30. There was a significant decrease in ∆POP in responders when compared to the nonresponders(p<0.05. ∆POP can be reduced by PLR and fluid responsiveness can be predicted noninvasively in mechanically ventilated patients during general anesthesia.

  13. IMPLEMENTASI PENGELOLAAN SUMBER DAYA PESISIR BERBASIS PENGELOLAAN WILAYAH PESISIR SECARA TERPADU UNTUK KESEJAHTERAAN NELAYAN (Studi di Perdesaan Nelayan Cangkol Kelurahan Lemahwungkuk Kecamatan Lemahwungkuk Kota Cirebon

    Directory of Open Access Journals (Sweden)

    Endang Sutrisno

    2014-01-01

    Full Text Available Coastal zone management in local area, especially in Cirebon has a deep tendency to be partial, the policies issued are not well-integrated among the sectors. Meanwhile, in the other hand, the im-plementation of policies are not support by the culture of fishing communities which apathetic. It is caused by various factors such as poverty, poor education in the community, less mastery of science and technology, as well as the marketing of fishery products trade system which is dominated by middlemen. This factual circumstance makes them difficult to realize their independence and well-being. The most appropriate solution to overcome this problem is through development of positive and creative legal culture, with the support of integrated coastal zone management policy that is integral-holistic-comprehensive.

  14. Aktivitas Antibakteri Ekstrak Jeruju (Acanthus ilicifolius terhadap Pertumbuhan Vibrio harveyi Secara in vitro (ANTIBACTERIAL ACTIVITY OF JERUJU (ANACTHUS ILICIFOLIUS EXTRACTS ON THE GROWTH OF VIBRIO HARVEYI IN VITRO

    Directory of Open Access Journals (Sweden)

    Gina Saptiani

    2013-07-01

    Full Text Available The aim of this research was to study the potential of jeruju (Acanthus ilicifolius extract as anantibacterial for alternative therapy and control of bacterial diseases in prawn nurseries. Ethanol extractionwas prepared from jeruju’s leaves, trunks, fruits, and flowers..Each extract was prepared at differentconcentrations (50 ppm, 100 ppm, 200 ppm, 300 ppm, 400 ppm, 500 ppm, 600 ppm, 700 ppm, 800 ppm,900 ppm, and 1000 ppm, respectively and further tested its antibacterial activity against Vibrio harveyiusing the agar disc diffusion method. The results showed that A. ilicifolius is a potential antibacterial,extract of the leaves seemed to be more effective in inhibit the growth of V. harveyi compared to other partsof the plant.

  15. Analisis Kandungan Timbal (Pb) Dan Kadmium (Cd) Pada Kangkung Air (Ipomoea aquatica Forssk) DAN kangkung Darat (Ipomoea reptans Poir) Di Daerah Mabar-Kim Secara Spektrofotometri Serapan Atom

    OpenAIRE

    Sari, Arisa Dian

    2011-01-01

    Kangkung is a kind of vegetables that is commonly consumed by people and it contains a lot of vitamin A. Surrounding the Industry Area in Medan such as Mabar, vegetables are planted by people, one of them is kangkung. Since the industries growth in the area of the vegetables are expanded, it is wondered that the kangkung has been contaminated by lead and cadmium metals. The purpose of this research is to know the lead and cadmium metals of water kangkung and land kangkung planted in Mabar the...

  16. Pelacakan Secara Imunohistokimiawi Antigen Virus pada Ayam yang Diinfeksi dengan Virus Penyakit Tetelo (IMMUNOHISTOCHEMICAL DETECTION OF VIRAL ANTIGEN IN TISSUE OF CHICKENS EXPERIMENTALLY INFECTED WITH NEWCASTLE DISEASE VIRUS

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    Anak Agung Ayu Mirah Adi

    2013-07-01

    Full Text Available In order to study the distribution of Newcastle disease virus (NDV following infection, chickenswere experimentally infected with visceretropic velogenic NDV isolate. Monoclonal antibodies (mAbsagainst the NDV LaSota vaccine strain were then produced to detect viral antigen in the infectedorgans. The mAbs were firstly tested for their specificity by enzyme linked immunosorbent assay(ELISA using NDV and normal allantoic fluids as antigens. Eight mAbs specific against NDVwere isolated and two mAbs were used for immunodetection of NDV antigen in chicken’s tissues.By immunohistochemistry labeled streptavidin-biotin (LSAB staining NDV–antigen was detectedin paraffin embedded tissues of NDV-infected chickens. NDV antigen was not detected in noninfected chickens. In the infected chickens, high intensity of NDV antigen was detected in thelymphoid tissues, lung and intestine. The NDV antigen with a lesser intensity was detected in thebrain, trachea, liver and myocardium. This study shows that although viscerotropic velogenicNDV isolate can infect almost all organs, the main target of infection are lung, intestine andlymphoids tissues

  17. Pemeriksaan Kandungan Logam Merkuri, Timbal, dan Kadmium dalam Daging Rajungan Segar yang Berasal dari TPI Gabion Belawan Secara Spektrofotometri Serapan Atom

    OpenAIRE

    Lubis, Hayati; Aman, Chalikuddin

    2010-01-01

    A research has been done to determine the quantitative of mercury (Hg), lead (Pb), and cadmium (Cd) in meat of crab which was taken from TPI Gabion Belawan. The determination of the metals was done by qualitative and quantitative methods. Qualitative analysis by using Na2S 10% b/v and dithizone 0,005% b/v reagent at the diffrent pH. The reaction with Na2S 10% b/v reagent will occur turbidity to the metals, where as with the dithizone 0,005% b/v reagent for Hg is not give a change of colour ch...

  18. Pengaruh Kepercayaan, Kemudahan, dan Kualitas Informasi Terhadap Keputusan Pembelian Secara Online Di Situs Lazada.co.id Pada Mahasiswa/I Fakultas Ekonomi Dan Bisnis USU

    OpenAIRE

    Sari, Maya Puspa

    2015-01-01

    The purpose of this study was to determine and analyze the influence of the trust, easy to use, and information quality on online buying decision in lazada.co.id of the Students at Faculty of Economics and Business University of North Sumatera. This research is associative causal research aimed to analyze the relationship between one variable with another variable or how a variable affecting other variables. The population in this study is an active student who ever made a online shopping who...

  19. Studi Penetapan Kadar Kandungan Vitamin C Pada Beberapa Macam Buah Mangga (Mangifera Indica L.) Yang Beredar Di Kota Medan Secara Volumetri Dengan 2,6-Diklorofenol Indofenol

    OpenAIRE

    Lubis, Suci Rahmalia

    2013-01-01

    Vitamin C is that the one of vitamin that needed by the body to increase of the immune system. To complement the necessary of vitamin C, as a source of vitamin C is fresh fruits. Mango fruit is one of the very popular and liked by the public that contain vitamin C. The purpose of this research was to compare the contain of vitamin C in the of Arumanis mango, Golek mango and Shrimp mango that circulating in the city of Medan by the volumetric method with a solution of 2,6-Dic...

  20. Korelasi indeks morfologi wajah dengan sudut interinsisal dan tinggi wajah secara sefalometri (Cephalometric correlation of facial morphology index with interincisal angle and facial height

    Directory of Open Access Journals (Sweden)

    Pricillia Priska Sianita K

    2013-12-01

    Full Text Available Background: In a disaster or criminal case, comprehensive information is needed for identification process of each victim. Especially for some cases that only leave skull without any information that could help the identification process, including face reconstruction that will be needed. One way of identifications is specific face characteristic, race, some head-neck measurements, such as facial morphology index, interincisal angle and facial height. Purpose: The aim of study was to determine the correlation of facial morphology index with interincisal angle and facial height through cephalometric measurement. Methods: The samples were cephalogram of 31 subjects (Deutro-Malayid race who met the inclusive criteria. Cephalometric analysis were done to all samples and followed by Pearson Correlation statistical test. Results: The correlation was found between facial morphology index and facial height, but no correlation between facial morphology index and interincisal angle. Conclusion: The study showed that the cephalometric measurement of facial morphology index and facial height could be used as the additional information for identification process.Latar belakang: Dalam bencana alam atau kasus kriminal informasi yang komprehensif diperlukan untuk proses identifikasi masing korban. Khususnya pada beberapa kasus yang hanya meninggalkan tengkorak tanpa informasi yang dapat membantu proses identifikasi, termasuk rekonstruksi wajah yang akan dibutuhkan. Salah satu cara identifikasi karakteristik wajah tertentu, ras, beberapa pengukuran kepala leher, seperti indeks morfologi wajah, sudut interincisal dan tinggi wajah. Tujuan: Penelitian ini bertujuan meneliti korelasi indeks morfologi wajah dengan sudut interincisal dan tinggi wajah melalui pengukuran sefalometrik. Metode: Sampel penelitian adalah cephalogram dari 31 subyek ras Deutro - Malayid ras yang memenuhi kriteria inklusif. Analisis cephalometri dilakukan pada semua sampel dan dilanjutkan dengan uji statistik korelasi Pearson. Hasil: Korelasi ditemukan antara indeks morfologi wajah dan tinggi wajah, tapi tidak ada korelasi antara indeks morfologi wajah dan sudut interincisal. Simpulan: Hasil penelitian menunjukkan bahwa pengukuran sefalometrik indeks morfologi wajah dan tinggi wajah, dapat digunakan sebagai informasi tambahan untuk proses identifikasi.

  1. ANALISA FLAVONOID DARI EKSTRAK ETANOL 96% KULIT BUAH OKRA MERAH (Abelmoschus esculentus L. Moench SECARA KROMATOGRAFI LAPIS TIPIS DAN SPEKTROFOTOMETRI UV-VIS

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    Nia Lisnawati

    2016-03-01

    Full Text Available Has done research on flavonoids Analysis of Ethanol Extract 96% Fruit Leather Red Okra In Thin Layer Chromatography and Spectrophotometer UV-Vis. The purpose of this study was to analyze the content of the fruit skin red okra (Abelmoschus esculentus L. Moench by using the method of thin layer chromatography (TLC under UV light and spectrophotometry UV-Vis. Reference standards used in this study is the Standard Solution Routine Quercetin. The results of the research that has been done by the method of thin layer chromatography obtained Rf values of 0.81 and produces the color orange. And the results of research conducted by spectrophotometry UV-Vis method obtained 333,117 mg.L-1 or 421,629 mg.kg-1 or 0,84339 %. The conclusion from this study is that the 96% ethanol extract of the fruit leather red okra (Abelmoschus esculentus L. Moench positive (+ contains flavonoids with levels of 0,84339 %.

  2. Pemecahan Dormansi Dan Perkecambahan Asam Kuranji (Dialium Indum L.) Secara Mekanis Dan Kimiawi Breaking Dormancy and Seeds Germination of Asam Kuranji (Dialium Indum L.) with Mechanical and Chemical

    OpenAIRE

    Ismuhajaroh, Bakti Nur

    2014-01-01

    The purpose of the study was to find out the dormancy breaking and the seed germination of Asam kuranji (Dialium indum L.) mechanically by sandpapering the seeds and chemically by immersing them in sulfuric acid (H2SO4). The experiment was conducted at the Plant Physiology Laboratory of Agricultural Faculty of Lambung Mangkurat University from June - August 2013 using Completely Randomized Design (CRD) with 2 x 4 factorial. The first factor was the mechanical treatment  (s0 = without sandpape...

  3. Analisis Kelarutan Kalsium Oksalat dan Kalsium Karbonat Pada Infus Daun Tempuyung Segar (Sonchus arvensis L.) dan Sediaan Kapsul Ekstrak Daun Tempuyung secara Spektrofotometri Serapan Atom

    OpenAIRE

    Alfim, Yasri

    2015-01-01

    Calcium oxalate (CaC2O4) and calcium carbonate (CaCO3) was a precursor of urinary tract stones or kidney stones are poorly soluble in water. Sow thistle (Sonchus arvensis L) was a plant which has efficacy dissolve kidney stone and launch urine (diuretic). This plant could be found easily in all around us. Potassium would eliminate of calcium compounds to join with carbonate, oxalate, or uric which was forming kidney stones so that it will dissolve kidney stones slowly and come out with urine....

  4. Identification and Characterization of Hyphantria cunea Aminopeptidase N as a Binding Protein of Bacillus thuringiensis Cry1Ab35 Toxin

    Directory of Open Access Journals (Sweden)

    Yakun Zhang

    2017-11-01

    Full Text Available The fall webworm, Hyphantria cunea (Drury is a major invasive pest in China. Aminopeptidase N (APN isoforms in lepidopteran larvae midguts are known for their involvement in the mode of action of insecticidal crystal (Cry proteins from Bacillus thuringiensis. In the present work, we identified a putative Cry1Ab toxin-binding protein, an APN isoform designated HcAPN3, in the midgut of H. cunea by ligand blot and mass spectrometry. HcAPN3 was highly expressed throughout all larval developmental stages and was abundant in the midgut and hindgut tissues. HcAPN3 was down-regulated at 6 h, then was up-regulated significantly at 12 h and 24 h after Cry1Ab toxin treatment. We expressed HcAPN3 in insect cells and detected its interaction with Cry1Ab toxin by ligand blot assays. Furthermore, RNA interference (RNAi against HcAPN3 using oral delivery and injection of double-stranded RNA (dsRNA resulted in a 61–66% decrease in transcript level. Down-regulating of the expression of HcAPN3 was closely associated with reduced susceptibility of H. cunea to Cry1Ab. In addition, the HcAPN3E fragment peptide expressed in Escherichia coli enhanced Cry1Ab toxicity against H. cunea larvae. This work represents the first evidence to suggest that an APN in H. cunea is a putative binding protein involved in Cry1Ab susceptibility.

  5. Factors influencing advanced practice nurses' ability to promote evidence-based practice among frontline nurses.

    Science.gov (United States)

    Gerrish, Kate; Nolan, Mike; McDonnell, Ann; Tod, Angela; Kirshbaum, Marilyn; Guillaume, Louise

    2012-02-01

    Advanced practice nurses (APNs) have an important role in promoting evidence-based practice (EBP) among frontline nurses (FLNs). Factors influencing FLNs' engagement with EBP are well documented but little is known about factors that affect APNs' ability to facilitate evidence in practice. To identify factors that influence APNs' ability to promote EBP among FLNs. A multiple case study of 23 APNs from hospital and primary care settings across seven English health authorities was undertaken. Data collection comprised interviews and observation of APNs and interviews with FLNs and other healthcare professionals. Data were analysed using the Framework approach. Four groups of influencing factors were identified: (1) Personal attributes of APNs included knowledge and skills in EBP, clinical credibility with frontline staff and leadership style. (2) Relationships with stakeholders included APNs' interactions with FLNs and the level of support from managers and medical colleagues. (3) Aspects of the APN role included their sphere of responsibility and workload. (4) Organisational context included the organisational culture, FLNs' workload, professional networks and available resources. Educational preparation for APNs should enable them to develop expertise in EBP plus interpersonal and leadership skills to manage relational dynamics in clinical settings. APN role specifications should provide the opportunity to promote EBP. The organisational culture should be conducive to enabling EBP with managers supportive of this aspect of the APNs' role. APNs need to be supported to address the individual, interpersonal and organisational factors, which influence their ability to promote EBP. Organisational commitment at the highest level is key to APNs' ability to fulfil this aspect of their role. ©2011 Sigma Theta Tau International.

  6. [Acute complicated and uncomplicated pyelonephritis in the emergency department: process-of-care indicators and outcomes].

    Science.gov (United States)

    Delgado Vicente, Miriam; Lecaroz Agara, Mª Concepción; Barrios Andrés, José Luis; Canut Blasco, Andrés

    2017-02-01

    To assess process-of-care indicators and outcomes in acute pyelonephritis (APN) in a general hospital emergency department, and compare them between uncomplicaed and complicated APN. Retrospective study of consecutive patients discharged with a diagnosis of APN. We studied health processof- care indicators (percentage admitted, avoidable hospitalization, appropriate initial antibiotic therapy, urine and blood cultures) and outcomes (hospital length of stay [LOS], discharge from the emergency department, revisits, mortality, yields of microbiological tests ordered). A total of 529 cases (59% of them complicated) were included. Patients with uncomplicated APN were significantly younger on average (mean, 39 years) than patients with complicated APN (56 years). Escherichia coli was the most common pathogen identified, although the percentage of E coli infection was lower in patients with complicated APN (78%) than in patients with uncomplicated APN (95%). The rates of admission and orders for urine and blood cultures were significantly higher and hospital LOS was longer in the group with complicated APN. Moreover, these patients had even longer stays if the initial antibiotic therapy was inappropriate. Significantly more patients with uncomplicated APN were discharged from the emergency department. Sixty-one percent of patients with uncomplicated APN were admitted; 9% of these cases were considered avoidable hospitalizations. Complicated APN is diagnosed more often in older patients, and E coli infection causes a smaller proportion of these cases. Hospital LOS is longer in complicated APN and more urine and blood cultures are ordered. Patients with uncomplicated APN are more often discharged from the emergency department, although the number of avoidable hospitalizations seems high based on the rate found in this study.

  7. E-selectin ligand-1 (ESL-1) is a novel adiponectin binding protein on cell adhesion

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Hiroyasu; Kuroda, Nana; Uekita, Hiromi; Kochi, Ikoi; Matsumoto, Akane; Niinaga, Ryu [Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka (Japan); Funahashi, Tohru; Shimomura, Iichiro [Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka (Japan); Kihara, Shinji, E-mail: skihara@sahs.med.osaka-u.ac.jp [Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka (Japan)

    2016-02-05

    Background: Adiponectin (APN) is an adipocyte-derived bioactive molecule with anti-diabetic and anti-atherogenic properties. Although anti-diabetic effects are mostly mediated by the adiponectin receptors AdipoR1 and AdipoR2, the anti-atherogenic mechanisms have not been fully elucidated. Methods and Results: In this study, we identified E-selectin ligand (ESL)-1 as a novel APN-binding protein by mass spectrometry analysis of HepG2 cell-derived immunoprecipitant with an anti-APN antibody. Cell adhesion assays using fluorescence-labelled monocyte cell line THP-1 cells and human umbilical vein endothelial cells (HUVECs) revealed that APN-pre-treated THP-1 cells had reduced binding ability to HUVECs. This APN-mediated suppressive effect on monocyte binding to endothelial cells was partially abrogated by targeting ESL-1 with shRNA in THP-1 cells. In addition, serial mutagenesis analysis disclosed that five extracellular amino acids close to the N-terminus of ESL-1 were essential for binding with APN. Conclusion: Our results highlight the fact that interaction between APN and ESL-1 could provide a fundamental mechanism underlying the anti-atherogenic properties of APN. - Highlights: • E-selectin ligand (ESL)-1 was identified as an adiponectin (APN)-binding protein. • ESL-1 bound to APN at its N-terminal 6th-10th amino acids. • shESL-1 reduced the suppressive effect of APN on adhesion of THP-1 cells to HUVECs. • Interaction with ESL may be involved in the anti-atherogenic effects of APN.

  8. E-selectin ligand-1 (ESL-1) is a novel adiponectin binding protein on cell adhesion

    International Nuclear Information System (INIS)

    Yamamoto, Hiroyasu; Kuroda, Nana; Uekita, Hiromi; Kochi, Ikoi; Matsumoto, Akane; Niinaga, Ryu; Funahashi, Tohru; Shimomura, Iichiro; Kihara, Shinji

    2016-01-01

    Background: Adiponectin (APN) is an adipocyte-derived bioactive molecule with anti-diabetic and anti-atherogenic properties. Although anti-diabetic effects are mostly mediated by the adiponectin receptors AdipoR1 and AdipoR2, the anti-atherogenic mechanisms have not been fully elucidated. Methods and Results: In this study, we identified E-selectin ligand (ESL)-1 as a novel APN-binding protein by mass spectrometry analysis of HepG2 cell-derived immunoprecipitant with an anti-APN antibody. Cell adhesion assays using fluorescence-labelled monocyte cell line THP-1 cells and human umbilical vein endothelial cells (HUVECs) revealed that APN-pre-treated THP-1 cells had reduced binding ability to HUVECs. This APN-mediated suppressive effect on monocyte binding to endothelial cells was partially abrogated by targeting ESL-1 with shRNA in THP-1 cells. In addition, serial mutagenesis analysis disclosed that five extracellular amino acids close to the N-terminus of ESL-1 were essential for binding with APN. Conclusion: Our results highlight the fact that interaction between APN and ESL-1 could provide a fundamental mechanism underlying the anti-atherogenic properties of APN. - Highlights: • E-selectin ligand (ESL)-1 was identified as an adiponectin (APN)-binding protein. • ESL-1 bound to APN at its N-terminal 6th-10th amino acids. • shESL-1 reduced the suppressive effect of APN on adhesion of THP-1 cells to HUVECs. • Interaction with ESL may be involved in the anti-atherogenic effects of APN.

  9. The anti-inflammatory effect of Andrographis paniculata (Burm. f.) Nees on pelvic inflammatory disease in rats through down-regulation of the NF-κB pathway.

    Science.gov (United States)

    Zou, Wei; Xiao, Zuoqi; Wen, Xiaoke; Luo, Jieying; Chen, Shuqiong; Cheng, Zeneng; Xiang, Daxiong; Hu, Jian; He, Jingyu

    2016-11-25

    Andrographis paniculata (Burm. f.) Nees (APN), a principal constituent of a famous traditional Chinese medicine Fukeqianjin tablet which is used for the treatment of pelvic inflammatory disease (PID), has been reported to have anti-inflammatory effect in vitro. However, whether it has pharmacological effect on PID in vivo is unclear. Therefore, the aim of this study is to test the anti-inflammatory effect of APN and illuminate a potential mechanism. Thirty-six female specific pathogen-free SD rats were randomly divided into control group, PID group, APN1 group, APN2 group, APN3 group and prednisone group. Pathogen-induced PID rats were constructed. The APN1, APN2 and APN3 group rats were orally administrated with APN extract at different levels. The prednisone group rats were administrated with prednisone. Eight days after the first infection, the histological examination of upper genital tract was carried out, and enzyme-linked immunosorbent assay (ELISA) was carried out using homogenate of the uterus and fallopian tube. Furthermore, immunohistochemical evaluations of NF-κB p65 and IκB-α in uterus was conducted. APN obviously suppressed the infiltrations of neutrophils and lymphocytes, and it could significantly reduce the excessive production of cytokines and chemokines including IL-1β, IL-6, CXCL-1, MCP-1 and RANTES in a dose-dependent manner. Furthermore, APN could block the pathogen-induced activation of NF-κB pathway. APN showed potent anti-inflammatory effect on pathogen-induced PID in rats, with a potential mechanism of inhibiting the NF-κB signal pathway.

  10. Human milk adiponectin affects infant weight trajectory during the second year of life.

    Science.gov (United States)

    Woo, Jessica G; Guerrero, M Lourdes; Guo, Fukun; Martin, Lisa J; Davidson, Barbara S; Ortega, Hilda; Ruiz-Palacios, Guillermo M; Morrow, Ardythe L

    2012-04-01

    Serum adiponectin (APN) is associated with lower childhood obesity, and APN concentration in human milk is associated with slower growth during active breast-feeding. We examined infant weight gain in the second year of life after exposure to high or low levels of mother's milk APN. Breast-feeding mother-infant pairs were recruited in Mexico City and studied for 2 years; 192 infants with at least 12 months' follow-up were analyzed. Monthly milk samples were assayed for APN; mothers were classified as producing high or low levels of milk APN. Infant and maternal serum APN were assessed during year 1. Infant anthropometry was measured monthly (year 1) or bimonthly (year 2), and World Health Organization z scores were calculated. Longitudinal adjusted models assessed weight-for-age and weight-for-length z score trajectories from 1 to 2 years. Maternal serum APN modestly correlated with milk APN (r=0.37, Pmilk APN experienced increasing weight-for-age and weight-for-length z scores between age 1 and 2 years in contrast to low milk APN exposure (P for group × time=0.02 and 0.054, respectively), adjusting for growth in the first 6 months and other covariates. In contrast, infant serum APN in year 1 was not associated with the rate of weight gain in year 2. High human milk APN exposure was associated with accelerated weight trajectory during the second year of life, suggesting its role in catch-up growth after slower weight gain during the first year of life.

  11. AFETR Instrumentation Handbook

    Science.gov (United States)

    1971-09-01

    90 TELEMETRY 0 U- a. 00 m 00~0 0L 0- uiu o of U- u 0 > IL a__3c 00f z X I- I-- 00 ( Sdg )l 08L) J:)I?j Oi to- zn M 00 LuU co 0 he o~~0 I-i zw~~~- ~ca LL...ARN-6 DFA-70 4. APN-70 LORAN x 5. N-l Compass System X X 6. True Air Speed Ind Sys X X 7. APN-59 SEarch Radar X X 8. Doppler Nav Radar APN-82 APN-147 9

  12. Globular Adiponectin Attenuated H2O2-Induced Apoptosis in Rat Chondrocytes by Inducing Autophagy Through the AMPK/ mTOR Pathway.

    Science.gov (United States)

    Hu, Junzheng; Cui, Weiding; Ding, Wenxiao; Gu, Yanqing; Wang, Zhen; Fan, Weimin

    2017-01-01

    Chondrocyte apoptosis is closely related to the development and progression of osteoarthritis. Global adiponectin (gAPN), secreted from adipose tissue, possesses potent anti-inflammatory and antiapoptotic properties in various cell types. This study aimed to investigate the role of autophagy induced by gAPN in the suppression of H2O2-induced apoptosis and the potential mechanism of gAPN-induced autophagy in chondrocytes. H2O2 was used to induce apoptotic injury in rat chondrocytes. CCK-8 assay was performed to determine the viability of cells treated with different concentrations of gAPN with or without H2O2. Cell apoptosis was detected by flow cytometry and TUNEL staining. Mitochondrial membrane potential was examined using JC-1 fluorescence staining assay. The autophagy inhibitors 3-MA and Bafilomycin A1 were used to treat cells and then evaluate the effect of gAPN-induced autophagy. To determine the downstream pathway, chondrocytes were preincubated with the AMPK inhibitor Compound C. Beclin-1, LC3B, P62 and apoptosis-related proteins were identified by Western blot analysis. H2O2 (400 µM)-induced chondrocytes apoptosis and caspase-3 activation were attenuated by gAPN (0.5 µg/mL). gAPN increased Bcl-2 expression and decreased Bax expression. The loss of mitochondrial membrane potential induced by H2O2 was also abolished by gAPN. Furthermore, the antiapoptotic effect of gAPN was related to gAPN-induced autophagy by increased formation of Beclin-1 and LC3B and P62 degradation. In particular, the inhibition of gAPN-induced autophagy by 3-MA prevented the protective effect of gAPN on apoptosis induced by H2O2. Moreover, gAPN increased p-AMPK expression and decreased p-mTOR expression. Compound C partly suppressed the expression of autophagy-related proteins and restored the expression of p-mTOR suppressed by gAPN. Thus, the AMPK/mTOR pathway played an important role in the induction of autophagy and protection of H2O2-induced chondrocytes apoptosis by gAPN. gAPN

  13. Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Disease Severity

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    Kang Tang

    2017-01-01

    Full Text Available Haemorrhagic fever with renal syndrome (HFRS is characterised by an uncontrolled immune response that causes vascular leakage. Adiponectin (APN is an adipocytokine involved in prorevascularisation and immunomodulation. To investigate the possible effects of APN in the pathogenesis of HFRS, total and high molecular weight (HMW APN levels in the plasma of patients with HFRS were quantified using enzyme-linked immunosorbent assay (ELISA. Compared with those in healthy controls, the plasma total and HMW APN levels in patients were elevated to different degrees from the fever onset and remained high at the convalescent phase. Consistent with these results, western blot analysis additionally showed that low molecular weight (LMW, middle molecular weight (MMW, and HMW APN levels were all elevated and contributed to the elevation of the total APN level. Importantly, sustained high levels of total and HMW APN at the convalescent phase were significantly higher in patients with critical disease than those in patients with mild or moderate disease. Moreover, total and HMW APN levels negatively correlated with white blood cell count and positively correlated with platelet count and serum albumin level. These results may provide insights into understanding the roles of total and HMW APN in the pathogenesis of HFRS.

  14. Aminopeptidase-N-independent entry of porcine epidemic diarrhea virus into Vero or porcine small intestine epithelial cells.

    Science.gov (United States)

    Ji, Chun-Miao; Wang, Bin; Zhou, Jiyong; Huang, Yao-Wei

    2018-04-01

    A monkey cell line Vero (ATCC CCL-81) is commonly used for porcine epidemic diarrhea virus (PEDV) propagation in vitro. However, it is still controversial whether the porcine aminopeptidase N (pAPN) counterpart on Vero cells (Vero-APN) confers PEDV entry. We found that endogenous expression of Vero-APN was undetectable in the mRNA and the protein levels in Vero cells. We cloned the partial Vero-APN gene (3340-bp) containing exons 1 to 9 from cellular DNA and subsequently generated two APN-knockout Vero cell lines by CRISPR/Cas9 approach. PEDV infection of two APN-knockout Vero cells had the same efficiency as the Vero cells with or without neuraminidase treatment. A Vero cells stably expressing pAPN did not increase PEDV production. SiRNA-knockdown of pAPN in porcine jejunum epithelial cells had no effects on PEDV infection. The results suggest that there exists an additional cellular receptor on Vero or porcine jejunal cells independent of APN for PEDV entry. Copyright © 2018 Elsevier Inc. All rights reserved.

  15. Globular Adiponectin Attenuated H2O2-Induced Apoptosis in Rat Chondrocytes by Inducing Autophagy Through the AMPK/ mTOR Pathway

    Directory of Open Access Journals (Sweden)

    Junzheng Hu

    2017-08-01

    Full Text Available Background/Aims: Chondrocyte apoptosis is closely related to the development and progression of osteoarthritis. Global adiponectin (gAPN, secreted from adipose tissue, possesses potent anti-inflammatory and antiapoptotic properties in various cell types. This study aimed to investigate the role of autophagy induced by gAPN in the suppression of H2O2-induced apoptosis and the potential mechanism of gAPN-induced autophagy in chondrocytes. Methods: H2O2 was used to induce apoptotic injury in rat chondrocytes. CCK-8 assay was performed to determine the viability of cells treated with different concentrations of gAPN with or without H2O2. Cell apoptosis was detected by flow cytometry and TUNEL staining. Mitochondrial membrane potential was examined using JC-1 fluorescence staining assay. The autophagy inhibitors 3-MA and Bafilomycin A1 were used to treat cells and then evaluate the effect of gAPN-induced autophagy. To determine the downstream pathway, chondrocytes were preincubated with the AMPK inhibitor Compound C. Beclin-1, LC3B, P62 and apoptosis-related proteins were identified by Western blot analysis. Results: H2O2 (400 µM-induced chondrocytes apoptosis and caspase-3 activation were attenuated by gAPN (0.5 µg/mL. gAPN increased Bcl-2 expression and decreased Bax expression. The loss of mitochondrial membrane potential induced by H2O2 was also abolished by gAPN. Furthermore, the antiapoptotic effect of gAPN was related to gAPN-induced autophagy by increased formation of Beclin-1 and LC3B and P62 degradation. In particular, the inhibition of gAPN-induced autophagy by 3-MA prevented the protective effect of gAPN on apoptosis induced by H2O2. Moreover, gAPN increased p-AMPK expression and decreased p-mTOR expression. Compound C partly suppressed the expression of autophagy-related proteins and restored the expression of p-mTOR suppressed by gAPN. Thus, the AMPK/mTOR pathway played an important role in the induction of autophagy and protection of

  16. KEBIJAKAN HUKUM PIDANA DALAM MENANGGULANGI TINDAK PIDANA PERTAMBANGAN TENTANG MENDULANG EMAS SECARA TRADISIONAL YANG MENGAKIBATKAN PENCEMARAN DAN MENELAN KORBAN JIWA BERDASARKAN UNDANG-UNDANG NOMOR 4 TAHUN 2009 TENTANG PERTAMBANGAN MINERAL DAN BATU BARA (STUDI KASUS GUNUNG PONGKOR BOGOR)

    OpenAIRE

    Margo Hadi Pura, S.H., M.H.

    2016-01-01

    State of Indonesia is one country in the world that has natural resources that are very much whether it is renewable and can not be renewed (or unerewable). Examples of non-renewable wealth of the mining sector, among others, one of them a gold mine. Not all parts of Indonesia has a potential gold mine that has one gold mine is in the western part of Mount Pongkor Kab. Bogor, West Java. Until now, the hunt for gurandil (designation illegal gold miners) and traditional gold mining in this regi...

  17. Diagnosis Infeksi Streptococcus suis serotipe-2 pada Babi Secara Serologi dengan Muramidase Released Protein (SEROLOGICALLY DIAGNOSE OF STREPTOCOCCUS SUIS SEROTYPE-2 INFECTION IN PIGS BASED ON MURAMIDASE RELEASED PROTEIN

    Directory of Open Access Journals (Sweden)

    Siti Isrina Oktavia Salasia

    2016-01-01

    Full Text Available Streptococcus suis is a bacterial pathogen causing disease of pigs that characterized by meningitis,bronchopneumonia, arthritis, pericarditis, polyserositis and septicaemia. S. suis especially serotype 2 caninfect human (zoonotic with a special symptom of meningitis. The aim of this research was to detect S.suis infection based on muramidase released protein (MRP, as an important virulence marker of S. suis.S. suis serotype 2 strain P171 with phenotype of MRP+EF+ was used in this research. The MRP antigen wasextracted using lysozyme and separated by using sodium dodecyl sulphate-polyacrylamide gel electrophoresis(SDS-PAGE. Balb/c mice were imunized with 136 kDa MRP to produce antibody against MRP. Theantibody was evaluated by using enzyme linkage immunosorbent assay (ELISA. The results of the researchshowed that the antibody against MRP with molecular weight of 136 kDa could be produced on Balb/Cmice with the highest absorbance of 3,889 and could be used to detect field sera from infected pigs with200x dilution using ELISA antigen capture. Antibody against MRP could detect serologically of S. suisinfection in pigs in Papua with 50% seropositivy by using ELISA antigen capture and 40% by using dot blot.

  18. Reaksi Penataan Ulang Sigmatropik Hidrogen [1,3] Secara Termal dan Reaksi Penataan Ulang Prototropik [1,3] yang dikatalisis oleh Katalis Transfer Fase (Ptc , [18]-Crown Ether-6: Semi-Sintesis Vanili dari Eugenol

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    Hendra Wijaya

    2002-04-01

    Full Text Available Semi-synthesis of vanillin from eugenol can be divided into two step reactions namely, isomerization of eugenol intoisoeugenol, and cleavage oxidation of isomerization product into expected reaction product (vanillin. In this work isomerization of eugenol or eugenyl acetate into isoeugenol or isoeugenyl acetate has been done via the following reactions: (1 Sigmatropic hydrogen (1,3 thermalic rearrangement reaction: direct heating of eugenol or eugenyl acetate at 220oC for 8 hours can produce 52.2% of isoeugenol or 65.7% of isoeugenyl acetate (both chemical yields are measured by means nmr-spectrometer, where products are viscose yellow-brownish liquid as mixture of unseparated starting material and isomerization product. (2 Prototropic (1,3 rearrangement catalyzed by phase transfer catalyst (PTC: (18-crown ether-6 at room temperature can be afforded 71.4% of isoeugenol as light yellow liquid (mixture of unseparated starting material and isomerization product. Without any separation of mixture between isomerization product and starting material followed by subsequent cleavage oxidation using KMnO4 as oxidator in neutral condition catalyzed by phase transfer catalyst: (18-crown ether-6 at room temperature for 3 hours can be yielded 16.5-22.9% of vanillin (from the starting material; eugenol or eugenyl acetate. The spectroscopical data of synthetical vanillin is not rather different with the spectroscopical data of authentical natural vanillin.

  19. PENGARUH EKSTRAK JAMU TERHADAP AKTIVITAS SEL NATURAL KILLER DALAM MELISIS ALUR SEL LEUKIMIA (K-562 SECARA IN VITRO [The Effects of Commercial “Jamu” Extracts on Natural Killer Cell Activity in Lysing Leukemic Cell Line (K-562 in vitro

    Directory of Open Access Journals (Sweden)

    Elisa Veronica D.C. 2

    2002-04-01

    Full Text Available Natural killer (NK cell consitutes white blood cells which specifically functions in lysing tumor and virus invected cells. In this research, a commercial “Jamu” was tested to observe its effect on NK cells activity against leukemic cell lines (K562 in vitro. Jamu was extracted with hot water, diluted and added into cell cultures consisted of a mixture of human peripheric limphocyte cells, as the source of the effector NK cells, and K562 cell line i.e., the target cells which were cell line derived from human leukemia and had been labelled with H3-thymidine. The mixture of the cells were made by culturing the two cells at the ratio of 50:1 and 100 : 1, respectively. The results showed that lysing activity of NK cells in the presence of “Jamu” water extract measured as lysing percentage and lysing index increased only slightly, which were not statiscally significant. It should be considered that the test used in this research represents only a part of the lysing mechanism by NK cells against the target cells. An in vivo test for a period of time will be recessary to elucidate ffurther this NK cell activity.

  20. KEBIJAKAN HUKUM PIDANA DALAM MENANGGULANGI TINDAK PIDANA PERTAMBANGAN TENTANG MENDULANG EMAS SECARA TRADISIONAL YANG MENGAKIBATKAN PENCEMARAN DAN MENELAN KORBAN JIWA BERDASARKAN UNDANG-UNDANG NOMOR 4 TAHUN 2009 TENTANG PERTAMBANGAN MINERAL DAN BATU BARA (STUDI KASUS GUNUNG PONGKOR BOGOR

    Directory of Open Access Journals (Sweden)

    Margo Hadi Pura, S.H., M.H.

    2016-05-01

    Full Text Available State of Indonesia is one country in the world that has natural resources that are very much whether it is renewable and can not be renewed (or unerewable. Examples of non-renewable wealth of the mining sector, among others, one of them a gold mine. Not all parts of Indonesia has a potential gold mine that has one gold mine is in the western part of Mount Pongkor Kab. Bogor, West Java. Until now, the hunt for gurandil (designation illegal gold miners and traditional gold mining in this region occurred since a dozen years ago. Traditional gold mining has been causing pollution and casualties. The problems to be discussed in this issue is, how the criminal law policy in tackling criminal activity in the mining of gold panning traditionally causing pollution and casualties and how the preventive and repressive criminal law in tackling the crime of mining of gold panning traditionally resulting in pollution and fatalities. This research is normative where descriptive data types used are primary data obtained through field studies and secondary data obtained through library. The results of these discussions the government has made policies by monitoring conducted by the Forest Police Rapid Response in tackling gold mining has traditionally and the government has made prevention and action illegal mining of them, by the extension of the dangers of mines traditionally, the deprivation of the means of panning, tightening security and inspection in the area Pongkor mountain region, providing security and raids, seizing and coaching gurandil and undertake community empowerment program development.

  1. KOMPOSISI KIMIA DAN KRISTALINITAS TEPUNG PISANG TERMODIFIKASI SECARA FERMENTASI SPONTAN DAN SIKLUS PEMANASAN BERTEKANAN-PENDINGINAN (Chemical Composition and Crystallinity of Modified Banana Flour by Spontaneous Fermentation and Autoclaving-Cooling Cycle

    Directory of Open Access Journals (Sweden)

    Nurhayati Nurhayati

    2014-07-01

    (39,13 – 42,68% bk dibandingkan dengan yang satu siklus (29,34 – 35,93% bk. Proses pemanasan bertekananpendinginan menurunkan kristalinitas tepung pisang dari 18,74-20,08% menjadi 6,98-9,52%. Difraksi sinar X menunjukkan granula pati pisang adalah granula tipe C yang merupakan campuran dari granula tipe A dan tipe B. Kata kunci: Tepung pisang termodifikasi, fermentasi spontan, autoclaving-cooling cycles

  2. Pengaruh Penggunaan Fungisida Sintetis Dan Trichoderma SP. Secara Tunggal Atau Gabungan Terhadap Penyakit Hawar Pelepah Daun Padi Effect of Synthetic Fungicidal Application Alone or Mixed with Trichoderma SP. on Sheat Blight of Rice

    OpenAIRE

    Susilo, Pambudi; Soesanto, Loekas; Wachjadi, Muljo

    2005-01-01

    This research aimed at knowing the application effect of synthetic fungicide tebuconazole 25% alone or mixed with Trichoderma sp. on sheath blight disease and rice yield. The research was carried out at the Plant Disease Laboratory and the experimental field, the Faculty of Agriculture, the University of Jenderal Soedirman. Split Plot Design was used with Trichoderma sp. as main factor consisted of without and with antagonistic Trichoderma sp. applied on rice at 15, 30, and 45 and 55 days aft...

  3. Pengaruh Penambahan Chorionic Gonadotrophin pada Medium Maturasi terhadap Kemampuan Maturasi, Fertilisasi, dan Perkembangan Embrio secara In Vitro Kambing Peranakan Ettawa (The Effect of Chorionic Gonadotrophin Addition Into Maturation Medium on The Abili

    Directory of Open Access Journals (Sweden)

    Nurvina Septi Adifa

    2012-02-01

    the values of 40.8%, 11.4%, and 12.2% respectively. Based on the result it could be concluded that chorionic gonadotrophin addition into maturation medium had not increased ettawa crossbred oocytes maturation, fertilization, and in vitro cleavage rate. The best maturation, fertilization, and in vitro cleavage rate were found using maturation medium without any addition of chorionic gonadotrophin. (Key words: Does oocyte, Chorionic gonadotrophin, In vitro maturation, In vitro fertilization, In vitro embryo development

  4. Gambaran Patologi Bursa Fabricius Embrio Ayam Pascavaksinasi Gumboro Secara In Ovo Menggunakan Vaksin Lokal dan Komersial (PATHOLOGIC DESCRIPTION OF BURSA FABRICIUS CHICKEN EMBYROS AFTER IN OVO VACCINATED WITH LOCAL AND COMMERSIAL GUMBORO VACCINES

    Directory of Open Access Journals (Sweden)

    Sutiastuti Wahyuwardani

    2015-10-01

    Full Text Available Bursa Fabricius is a target organ of gumboro virus infection which is often damaged after vaccinationusing hot intermediate gumboro live vaccine. The purpose of this study was to assess pathologic effect oflocal and commercial gumboro vaccines . As many as 45 embryo chicken eggs at nine day old were used inthis research, then grouped into three groups of 15 embryos chicken eggs each, these were: Embryo chickeneggs without vaccination (Group I, vaccinated with IBD intermediate plus commercial vaccine (Group IIand IBD intermediate plus local vaccine (Group III. Vaccinations were done at 14 days old. All groups thenterminated each three embryos at 12 hours, 1, 2, 3 days post vaccination. The results showed that pathologicanatomic lesions could not be detected. Whereas pathologic lesions were detected in the group that werevaccinated with intermediate plus local IBD observed more severe than in the group that vaccinated withintermediate plus commercial IBD. Lesions such as edema, hemorrhages, necrosis of lymphoid cells wereobserved microscopically in embryo at 12 hours, 1, 2 and 3 days post vaccination in Group II and group III.The lesions were more severe at two days post vaccination causing some lymphoid follicles disappeared at three days post vaccination. However, they were not detected again in the bursa Fabricius three days afterhatching. Cells containing antigens of gumboro were detected in the bursa Fabricius of chicken embryo atone day until three days post vaccination, then disappeared after three days post hatch. It was concludedthat pathologic description of bursa fabricius showed that virus vaccines used for vaccinated IBD in ovowere still virulent, that can cause histopathologic lesions. The viruses are suggested to be more attenuatedbefore using as vaccine in ovo.

  5. Enhancement of Nonspecific Immune Response and Growth Performance of Litopenaeus vannamei by Oral Administration of Nucleotides (PENINGKATAN RESPONS IMUN NONSPESIFIK DAN PERFORMA PERTUMBUHAN LITOPENAEUS VANNAMEI MELALUI PEMBERIAN NUKLEOTIDA SECARA ORAL

    Directory of Open Access Journals (Sweden)

    Henky Manoppo

    2013-12-01

    Full Text Available This research evaluated the nonspecific immune responseand growth of Litopenaeus vannamei fednucleotide diet.  In Laboratory, juveniles were reared in two groups of glass aquaria, each with threereplications.  Shrimps in group one were fed nucleotide diet and in group two were fedpellet four consecutiveweeks. Total Haemocyte Count and Phenoleoxydase activity were evaluated at the end of feeding whilegrowth was measured at two weeks interval. At the end of feeding, shrimps were intramuscularlyinjectedwith Vibrio harveyi  0.1x106 cfu.shrimp-1.  In tambak, juveniles were raised in two groups of net cages(hapa, each with three replications. One group was fed nucleotide diet while the other wasfed pellet forfour weeks. Total Haemocyte Count of shrimp fed nucleotide diet significantly increased up to 87% higherthan shrimps fed pellet.  Phenoleoxydase activity of shrimp fed nucleotides diet also increased isignificantlyas compared to shrimp fed pellet (p=0.02. Higher resistance and growth were observed in shrimp fednucleotide diet. In tambak, weight gain of shrimp fed nucleotide was 35.75% greater than shrimp fedpellet. Survival rate (83.24% was higher than shrimp fed pellet (81.71%.  As conclusion, oral administrationof nucleotide at 400 mg.kg-1 diet could enhancethe nonspecific immune response, resistance, and growth ofL. vannamei.

  6. The climate impact on female acute pyelonephritis in Taiwan: A population-based study.

    Science.gov (United States)

    Liu, Jui-Ming; Chang, Yu-Lung; Hsu, Ren-Jun; Su, Her-Young; Teng, Sen-Wen; Chang, Fung-Wei

    2017-08-01

    Urinary tract infection (UTI) is the main reason of community-acquired infection which causes large losses in social economy. The individual as well as climate factors make changes on the incidence. Acute pyelonephritis (APN) is one of the most serious UTI in female. The object of our study is to analyze whether climate factors will have effect on the incidence of female APN in Taiwan. This study consisted of 14,568 female patients with APN from 2001 to 2013 in Taiwan and patients with repeated APN were excluded. The monthly climate data was collected from the Central Weather Bureau. The available monthly climate data included highest, lowest, and average level of temperatures, humidity, rainfall, total rain days, and sunshine hours. The total incidence of female APN was 23.44 each 10,000 populations. The incidence of APN was positively correlated with temperature (r = 0.66), sunshine hours (r = 0.45), rainfall (r = 0.42), rain days (r = 0.29), and humidity (r = 0.23) per month. There is the strongest correlation between the average monthly temperature and the incidence of APN (β = 0.54). The correlation with the incidence of APN was also followed by rain days (β = 0.28) and humidity (β = 0.27). There is a significant expression on the incidence of female APN affected by seasonality and climate parameters. The monthly average temperature has the strongest correlation with female APN. The results of this research may facilitate the potential preventive strategies on female APN. Copyright © 2017. Published by Elsevier B.V.

  7. Implementation and evaluation of a peer review process for advanced practice nurses in a university hospital setting.

    Science.gov (United States)

    Bergum, Shelly K; Canaan, Talitha; Delemos, Christi; Gall, Elizabeth Funke; McCracken, Bonnie; Rowen, Dave; Salvemini, Steve; Wiens, Kimberly

    2017-07-01

    Over the past decade, implementation of the peer review process for the development of the advanced practice nurse (APN) has been emphasized. However, little exists in the literature regarding APN peer review. The peer review process is intended to help demonstrate competency of care, enhance quality improvement measures, and foster the professional growth of the APN. APNs serving on a professional governance council within a university teaching hospital developed a model of peer review for APNs. Nine months after the tool was implemented, an anonymous follow-up survey was conducted. A follow-up request was sent 4 weeks later to increase the number of respondents. Likert scales were used to elicit subjective data regarding the process. Of 81 APNs who participated in the survey, more than half (52%) felt that the process would directly improve their professional practice. Survey results show that the peer review process affected APN professional practice positively. Additional research might include pathways for remediation and education of staff, evaluation of alternate methods to improve application to clinical practice, and collection of outcome data. The models presented provide a foundation for future refinement to accommodate different APN practice settings. ©2017 American Association of Nurse Practitioners.

  8. E-selectin ligand-1 (ESL-1) is a novel adiponectin binding protein on cell adhesion.

    Science.gov (United States)

    Yamamoto, Hiroyasu; Kuroda, Nana; Uekita, Hiromi; Kochi, Ikoi; Matsumoto, Akane; Niinaga, Ryu; Funahashi, Tohru; Shimomura, Iichiro; Kihara, Shinji

    2016-02-05

    Adiponectin (APN) is an adipocyte-derived bioactive molecule with anti-diabetic and anti-atherogenic properties. Although anti-diabetic effects are mostly mediated by the adiponectin receptors AdipoR1 and AdipoR2, the anti-atherogenic mechanisms have not been fully elucidated. In this study, we identified E-selectin ligand (ESL)-1 as a novel APN-binding protein by mass spectrometry analysis of HepG2 cell-derived immunoprecipitant with an anti-APN antibody. Cell adhesion assays using fluorescence-labelled monocyte cell line THP-1 cells and human umbilical vein endothelial cells (HUVECs) revealed that APN-pre-treated THP-1 cells had reduced binding ability to HUVECs. This APN-mediated suppressive effect on monocyte binding to endothelial cells was partially abrogated by targeting ESL-1 with shRNA in THP-1 cells. In addition, serial mutagenesis analysis disclosed that five extracellular amino acids close to the N-terminus of ESL-1 were essential for binding with APN. Our results highlight the fact that interaction between APN and ESL-1 could provide a fundamental mechanism underlying the anti-atherogenic properties of APN. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Biochemical characteristics and modulation by external and internal factors of aminopeptidase-N activity in the hepatopancreas of a euryhaline burrowing crab.

    Science.gov (United States)

    Michiels, M S; del Valle, J C; López Mañanes, A A

    2015-07-01

    Strikingly, in spite of its physiological importance, information about occurrence, biochemical characteristics and mechanisms of regulation of aminopeptidase-N (APN) in the hepatopancreas of intertidal euryhaline crabs is still lacking. In this work, we determined the occurrence, biochemical characteristics, response to environmental salinity and dopamine of APN in the hepatopancreas of the euryhaline crab Neohelice granulata (Dana 1851) from the open mudflat of Mar Chiquita coastal lagoon (Buenos Aires province, Argentina). APN activity was maximal at pH and temperature range of 7.6-9.0 and 37-45 °C, respectively. APN activity exhibited Michaelis-Menten kinetics (apparent Km = 0.19 ± 0.10 mM) (pH 7.6, 37 °C) and appeared to be sensitive to bestatin (I 50 = 15 mM) and EDTA (I 50 = 9 mM). In crabs acclimated to 10 psu (hyper-regulation conditions) and 37 psu (hypo-regulation conditions), APN activity was about 45 and 160% higher, respectively, than in 35 psu (osmoconformation). APN activity in the hepatopancreas was stimulated in vitro (about 137%) by 10(-4) M dopamine. Higher dopamine concentrations produced a similar extent of increase. The responses of APN activity to salinity and dopamine in vitro suggest the role of APN in digestive adjustments upon hyper and hypo-regulatory conditions and its modulation via direct mechanisms on hepatopancreas by dopamine.

  10. Advanced practice nursing in child maltreatment: practice characteristics.

    Science.gov (United States)

    Hornor, Gail; Herendeen, Pamela

    2014-01-01

    Child maltreatment is a problem of epidemic proportions in the United States. Pediatric nurse practitioners and other advanced practice nurses (APNs) have been caring for maltreated children for decades, yet to date no comprehensive assessment of their practice characteristics or their clinical and academic contributions to the field has been performed. The purpose of this study is to describe the practice characteristics of APNs who care for maltreated children. A descriptive design was used for this study. Child advocacy centers and children's hospitals were contacted to inquire about employment of child maltreatment APNs in their institution, and contact information for the lead APN was obtained. The Nurse Practitioner Survey was then sent to lead APNs by e-mail. The majority of APNs who work primarily in child maltreatment are pediatric nurse practitioners who work in child advocacy centers. They are providing care to children with physical and/or sexual abuse concerns; however, APNs provide care for children with all types of child maltreatment concerns. APNs play a vital role in the care of abused/neglected children. Their important contributions include not only clinical care but also the provision of clinical and didactic education to other professionals, parents, and the public. Research and publication are also essential to their role. Copyright © 2014 National Association of Pediatric Nurse Practitioners. Published by Mosby, Inc. All rights reserved.

  11. Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment.

    Science.gov (United States)

    Guzman-Rojas, Liliana; Rangel, Roberto; Salameh, Ahmad; Edwards, Julianna K; Dondossola, Eleonora; Kim, Yun-Gon; Saghatelian, Alan; Giordano, Ricardo J; Kolonin, Mikhail G; Staquicini, Fernanda I; Koivunen, Erkki; Sidman, Richard L; Arap, Wadih; Pasqualini, Renata

    2012-01-31

    Processes that promote cancer progression such as angiogenesis require a functional interplay between malignant and nonmalignant cells in the tumor microenvironment. The metalloprotease aminopeptidase N (APN; CD13) is often overexpressed in tumor cells and has been implicated in angiogenesis and cancer progression. Our previous studies of APN-null mice revealed impaired neoangiogenesis in model systems without cancer cells and suggested the hypothesis that APN expressed by nonmalignant cells might promote tumor growth. We tested this hypothesis by comparing the effects of APN deficiency in allografted malignant (tumor) and nonmalignant (host) cells on tumor growth and metastasis in APN-null mice. In two independent tumor graft models, APN activity in both the tumors and the host cells cooperate to promote tumor vascularization and growth. Loss of APN expression by the host and/or the malignant cells also impaired lung metastasis in experimental mouse models. Thus, cooperation in APN expression by both cancer cells and nonmalignant stromal cells within the tumor microenvironment promotes angiogenesis, tumor growth, and metastasis.

  12. The activity and the development of radioecology marine laboratory in Indonesia

    International Nuclear Information System (INIS)

    Lubis, E.; Umbara, H.; Yarbaini, S.; Unandjar, G.

    1999-01-01

    The activities in the field of marine radioecology in Indonesia are spreading in many government institutions and more focused in terrestrial. In this paper, beside the RML proposed is explained also the radioecology studies at NPP candidate site of Muria Peninsula during fiscal year 1997 - 1998 are reported

  13. Porcine aminopeptidase N binds to F4+ enterotoxigenic Escherichia coli fimbriae.

    Science.gov (United States)

    Xia, Pengpeng; Wang, Yiting; Zhu, Congrui; Zou, Yajie; Yang, Ying; Liu, Wei; Hardwidge, Philip R; Zhu, Guoqiang

    2016-02-09

    F4(+) enterotoxigenic Escherichia coli (ETEC) strains cause diarrheal disease in neonatal and post-weaned piglets. Several different host receptors for F4 fimbriae have been described, with porcine aminopeptidase N (APN) reported most recently. The FaeG subunit is essential for the binding of the three F4 variants to host cells. Here we show in both yeast two-hybrid and pulldown assays that APN binds directly to FaeG, the major subunit of F4 fimbriae, from three serotypes of F4(+) ETEC. Modulating APN gene expression in IPEC-J2 cells affected ETEC adherence. Antibodies raised against APN or F4 fimbriae both reduced ETEC adherence. Thus, APN mediates the attachment of F4(+) E. coli to intestinal epithelial cells.

  14. Capturing reimbursement for advanced practice nurse services in acute and critical care: legal and business considerations.

    Science.gov (United States)

    Buppert, Carolyn

    2005-01-01

    Advanced practice nurses (APNs) have been affected positively and negatively by recent changes in the way hospitals are financed. Among these changes are the shift from cost-based reimbursement to a prospective payment system and increased opportunities for billing APN services under the physician payment system. Positive effects include the need for hospitals to decrease the length of stay of hospitalized patients, leading to jobs for APNs who make the hospital course and discharge more efficient. Negative effects include budget shortfalls that lead to layoffs. This article explains the current financial landscape, including phenomena that are impeding the billing of APN services, and recommends adjustments so that the APN role will be on firm financial footing.

  15. Skeletal muscle secretome in Duchenne muscular dystrophy: a pivotal anti-inflammatory role of adiponectin.

    Science.gov (United States)

    Lecompte, S; Abou-Samra, M; Boursereau, R; Noel, L; Brichard, S M

    2017-07-01

    Persistent inflammation exacerbates the progression of Duchenne muscular dystrophy (DMD). The hormone, adiponectin (ApN), which is decreased in the metabolic syndrome, exhibits anti-inflammatory properties on skeletal muscle and alleviates the dystrophic phenotype of mdx mice. Here, we investigate whether ApN retains its anti-inflammatory action in myotubes obtained from DMD patients. We unravel the underlying mechanisms by studying the secretome and the early events of ApN. Primary cultures of myotubes from DMD and control patients were treated or not by ApN after an inflammatory challenge. Myokines secreted in medium were identified by cytokine antibody-arrays and ELISAs. The early events of ApN signaling were assessed by abrogating selected genes. ApN retained its anti-inflammatory properties in both dystrophic and control myotubes. Profiling of secretory products revealed that ApN downregulated the secretion of two pro-inflammatory factors (TNFα and IL-17A), one soluble receptor (sTNFRII), and one chemokine (CCL28) in DMD myotubes, while upregulating IL-6 that exerts some anti-inflammatory effects. These changes were explained by pretranslational mechanisms. Earlier events of the ApN cascade involved AdipoR1, the main receptor for muscle, and the AMPK-SIRT1-PGC-1α axis leading, besides alteration of the myokine profile, to the upregulation of utrophin A (a dystrophin analog). ApN retains its beneficial properties in dystrophic muscles by activating the AdipoR1-AMPK-SIRT1-PGC-1α pathway, thereby inducing a shift in the secretion of downstream myokines toward a less inflammatory profile while upregulating utrophin. ApN, the early events of the cascade and downstream myokines may be therapeutic targets for the management of DMD.

  16. Globular Adiponectin Inhibits the Apoptosis of Mesenchymal Stem Cells Induced by Hypoxia and Serum Deprivation via the AdipoR1-Mediated Pathway

    Directory of Open Access Journals (Sweden)

    Xia-Qiu Tian

    2016-02-01

    Full Text Available Background/Aims: Poor viability of transplanted mesenchymal stem cells (MSCs within the ischemic heart limits their therapeutic potential for cardiac repair. Globular adiponectin (gAPN exerts anti-apoptotic effects on several types of stem cells. Herein, we investigated the effect of gAPN on the MSCs against apoptosis induced by hypoxia and serum deprivation (H/SD. Methods: MSCs exposed to H/SD conditions were treated with different concentrations of gAPN. To identify the main type of receptor, MSCs were transfected with siRNA targeting adiponectin receptor 1 or 2 (AdipoR1 or AdipoR2. To elucidate the downstream pathway, MSCs were pre-incubated with AMPK inhibitor Compound C. Apoptosis, caspase-3 activity and mitochondrial membrane potential were evaluated. Results: H/SD-induced MSCs apoptosis and caspase-3 activation were attenuated by gAPN in a concentration-dependent manner. gAPN increased Bcl-2 and decreased Bax expressions. The loss of mitochondrial membrane potential induced by H/SD was also abolished by gAPN. The protective effect of gAPN was significantly attenuated after the knockdown of AdipoR1 rather than AdipoR2. Moreover, Compound C partly suppressed the anti-apoptotic effect of gAPN. Conclusions: gAPN inhibits H/SD-induced apoptosis in MSCs via AdipoR1-mediated pathway, possibly linked to the activation of AMPK. gAPN may be a novel survival factor for MSCs in the ischemic engraftment environment.

  17. Globular Adiponectin Inhibits the Apoptosis of Mesenchymal Stem Cells Induced by Hypoxia and Serum Deprivation via the AdipoR1-Mediated Pathway.

    Science.gov (United States)

    Tian, Xia-Qiu; Yang, Yue-Jin; Li, Qing; Huang, Pei-Sen; Li, Xiang-Dong; Jin, Chen; Qi, Kang; Jiang, Lei-Pei; Chen, Gui-Hao

    2016-01-01

    Poor viability of transplanted mesenchymal stem cells (MSCs) within the ischemic heart limits their therapeutic potential for cardiac repair. Globular adiponectin (gAPN) exerts anti-apoptotic effects on several types of stem cells. Herein, we investigated the effect of gAPN on the MSCs against apoptosis induced by hypoxia and serum deprivation (H/SD). MSCs exposed to H/SD conditions were treated with different concentrations of gAPN. To identify the main type of receptor, MSCs were transfected with siRNA targeting adiponectin receptor 1 or 2 (AdipoR1 or AdipoR2). To elucidate the downstream pathway, MSCs were pre-incubated with AMPK inhibitor Compound C. Apoptosis, caspase-3 activity and mitochondrial membrane potential were evaluated. H/SD-induced MSCs apoptosis and caspase-3 activation were attenuated by gAPN in a concentration-dependent manner. gAPN increased Bcl-2 and decreased Bax expressions. The loss of mitochondrial membrane potential induced by H/SD was also abolished by gAPN. The protective effect of gAPN was significantly attenuated after the knockdown of AdipoR1 rather than AdipoR2. Moreover, Compound C partly suppressed the anti-apoptotic effect of gAPN. gAPN inhibits H/SD-induced apoptosis in MSCs via AdipoR1-mediated pathway, possibly linked to the activation of AMPK. gAPN may be a novel survival factor for MSCs in the ischemic engraftment environment. © 2016 The Author(s) Published by S. Karger AG, Basel.

  18. The Role of the Advanced Practice Nurse in Geriatric Oncology Care.

    Science.gov (United States)

    Morgan, Brianna; Tarbi, Elise

    2016-02-01

    To describe how the Advanced Practice Nurse (APN) is uniquely suited to meet the needs of older adults throughout the continuum of cancer, to explore the progress that APNs have made in gero-oncology care, and make suggestions for future directions. Google Scholar, PubMed, and CINAHL. Search terms included: "gero-oncology," "geriatric oncology," "Advanced Practice Nurse," "Nurse Practitioner," "older adult," "elderly," and "cancer." Over the last decade, APNs have made advances in caring for older adults with cancer by playing a role in prevention, screening, and diagnosis; through evidence-based gero-oncology care during cancer treatment; and in designing tailored survivorship care models. APNs must combat ageism in treatment choice for older adults, standardize comprehensive geriatric assessments, and focus on providing person-centered care, specifically during care transitions. APNs are well-positioned to help understand the complex relationship between risk factors, geriatric syndromes, and frailty and translate research into practice. Palliative care must expand beyond specialty providers and shift toward APNs with a focus on early advanced care planning. Finally, APNs should continue to establish multidisciplinary survivorship models across care settings, with a focus on primary care. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. Implementation strategy for advanced practice nursing in primary health care in Latin America and the Caribbean.

    Science.gov (United States)

    Oldenburger, David; De Bortoli Cassiani, Silvia Helena; Bryant-Lukosius, Denise; Valaitis, Ruta Kristina; Baumann, Andrea; Pulcini, Joyce; Martin-Misener, Ruth

    2017-06-08

    SYNOPSIS Advanced practice nursing (APN) is a term used to describe a variety of possible nursing roles operating at an advanced level of practice. Historically, APN roles haves evolved informally, out of the need to improve access to health care services for at-risk and disadvantaged populations and for those living in underserved rural and remote communities. To address health needs, especially ones related to primary health care, nurses acquired additional skills through practice experience, and over time they developed an expanded scope of practice. More recently, APN roles have been developed more formally through the establishment of graduate education programs to meet agreed-upon competencies and standards for practice. The introduction of APN roles is expected to advance primary health care throughout Latin America and the Caribbean, where few such roles exist. The purpose of the paper is to outline an implementation strategy to guide and support the introduction of primary health care APN roles in Latin America and the Caribbean. The strategy includes the adaptation of an existing framework, utilization of recent research evidence, and application of knowledge from experts on APN and primary health care. The strategy consists of nine steps. Each step includes a national perspective that focuses on direct country involvement in health workforce planning and development and on implementation. In addition, each step incorporates an international perspective on encouraging countries that have established APN programs and positions to collaborate in health workforce development with nations without advanced practice nursing.

  20. Framework for Evaluating the Impact of Advanced Practice Nursing Roles.

    Science.gov (United States)

    Bryant-Lukosius, Denise; Spichiger, Elisabeth; Martin, Jacqueline; Stoll, Hansruedi; Kellerhals, Sabine Degen; Fliedner, Monica; Grossmann, Florian; Henry, Morag; Herrmann, Luzia; Koller, Antje; Schwendimann, René; Ulrich, Anja; Weibel, Lukas; Callens, Betty; De Geest, Sabina

    2016-03-01

    To address the gap in evidence-based information required to support the development of advanced practice nursing (APN) roles in Switzerland, stakeholders identified the need for guidance to generate strategic evaluation data. This article describes an evaluation framework developed to inform decisions about the effective utilization of APN roles across the country. A participatory approach was used by an international group of stakeholders. Published literature and an evidenced-based framework for introducing APN roles were analyzed and applied to define the purpose, target audiences, and essential elements of the evaluation framework. Through subsequent meetings and review by an expert panel, the framework was developed and refined. A framework to evaluate different types of APN roles as they evolve to meet dynamic population health, practice setting, and health system needs was created. It includes a matrix of key concepts to guide evaluations across three stages of APN role development: introduction, implementation, and long-term sustainability. For each stage, evaluation objectives and questions examining APN role structures, processes, and outcomes from different perspectives (e.g., patients, providers, managers, policy-makers) were identified. A practical, robust framework based on well-established evaluation concepts and current understanding of APN roles can be used to conduct systematic evaluations. The evaluation framework is sufficiently generic to allow application in developed countries globally, both for evaluation as well as research purposes. © 2016 Sigma Theta Tau International.

  1. Advanced Practice Nursing: A Strategy for Achieving Universal Health Coverage and Universal Access to Health

    Directory of Open Access Journals (Sweden)

    Denise Bryant-Lukosius

    Full Text Available ABSTRACT Objective: to examine advanced practice nursing (APN roles internationally to inform role development in Latin America and the Caribbean to support universal health coverage and universal access to health. Method: we examined literature related to APN roles, their global deployment, and APN effectiveness in relation to universal health coverage and access to health. Results: given evidence of their effectiveness in many countries, APN roles are ideally suited as part of a primary health care workforce strategy in Latin America to enhance universal health coverage and access to health. Brazil, Chile, Colombia, and Mexico are well positioned to build this workforce. Role implementation barriers include lack of role clarity, legislation/regulation, education, funding, and physician resistance. Strong nursing leadership to align APN roles with policy priorities, and to work in partnership with primary care providers and policy makers is needed for successful role implementation. Conclusions: given the diversity of contexts across nations, it is important to systematically assess country and population health needs to introduce the most appropriate complement and mix of APN roles and inform implementation. Successful APN role introduction in Latin America and the Caribbean could provide a roadmap for similar roles in other low/middle income countries.

  2. Impact of recombinant globular adiponectin on early warm ischemia-reperfusion injury in rat bile duct after liver transplantation.

    Science.gov (United States)

    Xia, Yang; Gong, Jian-Ping

    2014-09-19

    Adiponectin (APN) is an adipocyte protein with anti-diabetic properties, which has been recently revealed to have anti-inflammatory activity in organ ischemia- reperfusion injury (IRI). However, little is known about its function in bile duct IRI after liver transplantation. Therefore, we investigated whether APN affects early warm IRI in rat bile duct using a liver autologous transplantation model. In our study, rats were randomly divided into three experimental groups: a sham group, a IRI group, and a APN group. The serum enzyme levels and BDISS scores of bile duct histology associated with bile duct injury, decreased after administration of APN. Subsequently, the expression of proinflammatory cytokines, such as tumor necrosis factor(TNF-α),.interleukin-6(IL-6) and myeloperoxidase (MPO) decreased. Furthermore, pretreatment with APN suppressed the activation of nuclear factor-kappa B (NF-κB) (p65), a transcription factor involved in inflammatory reactions, compared to other two groups. Administration of APN also downregulated the expression of Fas protein and attenuated caspase-3 activity to decrease bile duct apoptosis. Our results illustrate that APN protects the rat bile duct against early warm IRI by suppressing the inflammatory response and hepatocyte apoptosis, and NF-κB (p65) plays an important role in this process.

  3. Building to Make a Difference: Advanced Practice Nurses' Experience of Power.

    Science.gov (United States)

    Schoales, Catherine A; Bourbonnais, Frances Fothergill; Rashotte, Judy

    2018-02-01

    Power is necessary for nurses to affect change in patient care and to move the nursing profession forward. Despite the evolving body of nursing research on power, there have been no studies that have investigated the nature of advanced practice nurses' (APNs') power. The purpose of this study was to explore the APNs' lived experience of power. Interpretive phenomenology guided the method and analysis. Eight APNs employed in a single Canadian tertiary care teaching health-care organization engaged in in-depth interviews. The overarching theme, building to make a difference, reflected the APNs' perception of power in their practice, which involved a passion to facilitate change in practice to improve patient care. Building to make a difference involved three themes: building on, building with, and building for. The APNs experienced more power-a process they described as power creep-when they used soft power that was shared with others to affect positive change in health care. These findings contribute to our understanding of how power is perceived and manifested in the APN role, thus further enabling organizations to create working conditions to support the APNs' endeavors to empower others.

  4. Transport of beta-aminopropionitrile through intact skin or scar tissue

    International Nuclear Information System (INIS)

    Gibeault, J.D.; Cravens, R.B. Jr.; Chvapil, M.

    1989-01-01

    A lathyrogen, [ 14 C]aminopropionitrile (beta APN), was administered to 34 rats either in K-Y jelly or saline vehicles onto intact shaven skin or onto a healed splinted deep excision wound. The dynamics of beta APN transport and content in the skin or repair tissue was observed after 2, 5, 8, and 24 hr of topical administration. The repair tissue quickly absorbed the lathyrogen and reached maximum at the 2-hr sampling. The content of beta APN in the repair tissue was twice as high as that in K-Y jelly vehicle and remained high and stable for at least 24 hr only when beta APN was administered through a saline vehicle. The transport of beta APN through intact skin, irrespective of the vehicle tested, was slow and continuously increased. The study showed that almost 20% of the beta APN administered onto the wounded skin area was transported into the repair tissue within 2 hr. We suggest that, due to the absence of epidermal stratum corneum from the repair tissue, drugs, such as beta APN, penetrate quickly into the wound

  5. Holistic health care: Patients' experiences of health care provided by an Advanced Practice Nurse.

    Science.gov (United States)

    Eriksson, Irene; Lindblad, Monica; Möller, Ulrika; Gillsjö, Catharina

    2018-02-01

    Advanced Practice Nurse (APN) is a fairly new role in the Swedish health care system. To describe patients' experiences of health care provided by an APN in primary health care. An inductive, descriptive qualitative approach with qualitative open-ended interviews was chosen to obtain descriptions from 10 participants regarding their experiences of health care provided by an APN. The data were collected during the spring 2012, and a qualitative approach was used for analyze. The APNs had knowledge and skills to provide safe and secure individual and holistic health care with high quality, and a respectful and flexible approach. The APNs conveyed trust and safety and provided health care that satisfied the patients' needs of accessibility and appropriateness in level of care. The APNs way of providing health care and promoting health seems beneficial in many ways for the patients. The individual and holistic approach that characterizes the health care provided by the APNs is a key aspect in the prevailing change of health care practice. The transfer of care and the increasing number of older adults, often with a variety of complex health problems, call for development of the new role in this context. © 2017 The Authors. International Journal of Nursing Practice Published by John Wiley & Sons Australia, Ltd.

  6. Gender differences in the relationships among obesity, adiponectin and brachial artery distensibility in adolescents and young adults.

    Science.gov (United States)

    Urbina, E M; Khoury, P; Martin, L J; D'Alessio, D; Dolan, L M

    2009-10-01

    Obesity-related cardiovascular diseases (CVDs) are a major cause of cardiovascular (CV) mortality. Obesity-related reduction in vascular protective adipose-derived proteins, such as adiponectin (APN), has an important role. We compared brachial artery distensibility (BrachD) with APN, the level of adiposity and other CV risk factors (CVRFs) in 431 post-pubertal subjects (mean 17.9 years). Gender differences in average values were examined by t-tests. Correlations among BrachD, obesity and other CVRFs were examined. Regression analysis was performed to determine whether APN provided an independent contribution to BrachD, while controlling for obesity and other CVRFs. Male subjects had lower BrachD (5.72+/-1.37 vs 6.45+/-1.60% change per mm Hg, Pgender, APN*gender and BMI z-score predicted BrachD (r(2)=0.305). On the basis of gender difference, only BMI z-score was significant for male subjects (r(2)=0.080), whereas APN and BMI z-score contributed for female subjects (r(2)=0.242, all Pobesity in both male and female subjects. In female subjects, APN exerts an additional independent effect even after adjusting for blood pressure (BP), lipid levels and insulin. Differences in the effect of the APN-adiposity relationship on obesity-related vascular disease may be one reason for gender differences in the development and progression of atherosclerosis.

  7. Caring in telehealth.

    Science.gov (United States)

    Varghese, Shainy B; Phillips, Carolyn A

    2009-12-01

    The overall goal of this study was to explore and describe the perceptions of advanced practice nurses (APNs) about caring while providing primary care using telehealth technology. This study used naturalistic inquiry methodology to elicit the subjective perceptions and reflections of a sample of APNs about how they convey caring in the context of telehealth. Thirteen APNs, selected by purposive and snowball sampling, participated in the study. The data for the study consisted of interviews conducted by e-mail using a semistructured interview guide. Data analysis used the constant comparison method; rigor and trustworthiness of the study procedures were established using the criteria of credibility, confirmability, dependability, and transferability. The findings of this study revealed that the APNs conveyed caring to their telehealth patients by (1) being with them, (2) personifying the images, and (3) possessing certain attributes. The major constructs that emerged from the data together formed a model of how APNs conveyed caring in telehealth. The findings provide insights and increase the understanding of how caring in telehealth was perceived by APNs. The findings of the study can make important contributions in improving our profession's preparation of future telehealth APNs. The study findings also can lend themselves to developing an instrument to measure caring in telehealth. The study findings also contribute to the nursing literature in a number of ways.

  8. Adiponectin protects palmitic acid induced endothelial inflammation and insulin resistance via regulating ROS/IKKβ pathways.

    Science.gov (United States)

    Zhao, Wenwen; Wu, Chuanhong; Li, Shaojing; Chen, Xiuping

    2016-12-01

    Endothelial inflammation and insulin resistance (IR) has been closely associated with endothelial dysfunction. Adiponectin (APN), an adipocyte-secreted hormone from adipose tissues, showed cardioprotective effects. Here, the protective effect of APN on palmitic acid (PA)-induced endothelial inflammation and IR was investigated. Cultured human umbilical vein endothelial cells (HUVECs) were treated with PA without or without APN pretreatment. The expression of inflammatory cytokines TNF-α, IL-6, adhesion molecule ICAM-1 were determined by western blotting, ELISA, and real-time PCR. The protein expression and protein-protein interaction were determined by western blotting and immunoprecipitation. The intracellular reactive oxygen species (ROS) and nitric oxide (NO) production were monitored with fluorescence probes. PA-induced secretion of TNF-α, IL-6, and expression of ICAM-1 at protein and mRNA levels, which was significantly inhibited by APN. PA treatment caused increase of ROS generation, NOX2, p-IKKβ, p-IκBα, p-p65 expression, and p-IκBα-IKKβ interaction, which were all partly reversed by APN. ROS scavenger N-acetylcysteine (NAC) and NF-κB inhibitor PDTC showed similar effect on PA-induced secretion of TNF-α, IL-6, and expression of ICAM-1. Furthermore, APN and NAC pretreatment restored PA-induced increase of p-IRS-1(S307), decrease of p-IRS-1(Tyr). In addition, insulin-triggered expression of p-IRS-1(Tyr), p-PI3K, p-AKT, p-eNOS and NO generation were inhibited by PA, which were also restored by both APN and NAC. These results suggested that APN ameliorated endothelial inflammation and IR through ROS/IKKβ pathway. This study shed new insights into the mechanisms of APN's cardiovascular protective effect. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Adiponectin attenuates angiotensin II-induced vascular smooth muscle cell remodeling through nitric oxide and the RhoA/ROCK pathway.

    Directory of Open Access Journals (Sweden)

    Wared eNour-Eldine

    2016-04-01

    Full Text Available INTRODUCTION: Adiponectin (APN, an adipocytokine, exerts protective effects on cardiac remodeling, while angiotensin II (Ang II induces hypertension and vascular remodeling. The potential protective role of APN on the vasculature during hypertension has not been fully elucidated yet. Here, we evaluate the molecular mechanisms of the protective role of APN in the physiological response of the vascular wall to Ang II.METHODS AND RESULTS: Rat aortic tissues were used to investigate the effect of APN on Ang II-induced vascular remodeling and hypertrophy. We investigated whether nitric oxide (NO, the RhoA/ROCK pathway, actin cytoskeleton remodeling, and reactive oxygen species (ROS mediate the anti-hypertrophic effect of APN. Ang II-induced protein synthesis was attenuated by pre-treatment with APN, NO donor (SNAP, or cGMP. The hypertrophic response to Ang II was associated with a significant increase in RhoA activation and vascular force production, which were prevented by APN and SNAP. NO was also associated with inhibition of Ang II-induced phosphorylation of cofilin. In addition, immunohistochemistry revealed that 24 hr Ang II treatment increased the F- to G-actin ratio, an effect that was inhibited by SNAP. Ang II-induced ROS formation and upregulation of p22phox mRNA expression were inhibited by APN and NO. Both compounds failed to inhibit Nox1 and p47phox expression. CONCLUSIONS: Our results suggest that the anti-hypertrophic effects of APN are due, in part, to NO-dependent inhibition of the RhoA/ROCK pathway and ROS formation.

  10. Intriguing interplay between feline infectious peritonitis virus and its receptors during entry in primary feline monocytes.

    Science.gov (United States)

    Van Hamme, Evelien; Desmarets, Lowiese; Dewerchin, Hannah L; Nauwynck, Hans J

    2011-09-01

    Two potential receptors have been described for the feline infectious peritonitis virus (FIPV): feline aminopeptidase N (fAPN) and feline dendritic cell-specific intercellular adhesion molecule grabbing non-integrin (fDC-SIGN). In cell lines, fAPN serves as a receptor for serotype II, but not for serotype I FIPV. The role of fAPN in infection of in vivo target cells, monocytes, is not yet confirmed. Both serotype I and II FIPVs use fDC-SIGN for infection of monocyte-derived cells but how is not known. In this study, the role of fAPN and fDC-SIGN was studied at different stages in FIPV infection of monocytes. First, the effects of blocking the potential receptor(s) were studied for the processes of attachment and infection. Secondly, the level of co-localization of FIPV and the receptors was determined. It was found that FIPV I binding and infection were not affected by blocking fAPN while blocking fDC-SIGN reduced FIPV I binding to 36% and practically completely inhibited infection. Accordingly, 66% of bound FIPV I particles co-localized with fDC-SIGN. Blocking fAPN reduced FIPV II binding by 53% and infection by 80%. Further, 60% of bound FIPV II co-localized with fAPN. fDC-SIGN was not involved in FIPV II binding but infection was reduced with 64% when fDC-SIGN was blocked. In conclusion, FIPV I infection of monocytes depends on fDC-SIGN. Most FIPV I particles already interact with fDC-SIGN at the plasma membrane. For FIPV II, both fAPN and fDC-SIGN are involved in infection with only fAPN playing a receptor role at the plasma membrane. Copyright © 2011 Elsevier B.V. All rights reserved.

  11. Effect of adiponectin deficiency on intestinal damage and hematopoietic responses of mice exposed to gamma radiation

    Energy Technology Data Exchange (ETDEWEB)

    Ponemone, Venkatesh; Fayad, Raja; Gove, Melissa E.; Pini, Maria [Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612 (United States); Fantuzzi, Giamila, E-mail: giamila@uic.edu [Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612 (United States)

    2010-08-07

    Adiponectin (APN) is an adipose tissue-derived cytokine that regulates insulin sensitivity and inflammation. It is also involved in modulation of cell proliferation by binding to various growth factors. Based on its known effects in modulating cell proliferation and oxidative stress, APN may potentially be involved in regulating tissue damage and repair following irradiation. Adiponectin KO mice and their WT littermates were exposed to a single whole-body dose of 3 or 6 Gy gamma radiation. Radiation-induced alterations were studied in jejunum, blood, bone marrow and thymus at days 1 and 5 post-irradiation and compared with sham-irradiated groups. In WT mice, irradiation did not significantly alter serum APN levels while inducing a significant decrease in serum leptin. Irradiation caused a significant reduction in thymocyte cellularity, with concomitant decrease in CD4{sup +}, CD8{sup +} and CD4{sup +}CD8{sup +} T cell populations, with no significant differences between WT and APN KO mice. Irradiation resulted in a significantly higher increase in the frequency of micronucleated reticulocytes in the blood of APN KO compared with WT mice, whereas frequency of micronucleated normochromatic erythrocytes in the bone marrow at day 5 was significantly higher in WT compared with APN KO mice. Finally, irradiation induced similar alterations in villus height and crypt cell proliferation in the jejunum of WT and APN KO mice. Jejunum explants from sham-irradiated APN KO mice produced higher levels of IL-6 compared with tissue from WT animals, but the difference was no longer apparent following irradiation. Our data indicate that APN deficiency does not play a significant role in modulating radiation-induced gastrointestinal injury in mice, while it may participate in regulation of damage to the hematopoietic system.

  12. Effect of adiponectin deficiency on intestinal damage and hematopoietic responses of mice exposed to gamma radiation

    International Nuclear Information System (INIS)

    Ponemone, Venkatesh; Fayad, Raja; Gove, Melissa E.; Pini, Maria; Fantuzzi, Giamila

    2010-01-01

    Adiponectin (APN) is an adipose tissue-derived cytokine that regulates insulin sensitivity and inflammation. It is also involved in modulation of cell proliferation by binding to various growth factors. Based on its known effects in modulating cell proliferation and oxidative stress, APN may potentially be involved in regulating tissue damage and repair following irradiation. Adiponectin KO mice and their WT littermates were exposed to a single whole-body dose of 3 or 6 Gy gamma radiation. Radiation-induced alterations were studied in jejunum, blood, bone marrow and thymus at days 1 and 5 post-irradiation and compared with sham-irradiated groups. In WT mice, irradiation did not significantly alter serum APN levels while inducing a significant decrease in serum leptin. Irradiation caused a significant reduction in thymocyte cellularity, with concomitant decrease in CD4 + , CD8 + and CD4 + CD8 + T cell populations, with no significant differences between WT and APN KO mice. Irradiation resulted in a significantly higher increase in the frequency of micronucleated reticulocytes in the blood of APN KO compared with WT mice, whereas frequency of micronucleated normochromatic erythrocytes in the bone marrow at day 5 was significantly higher in WT compared with APN KO mice. Finally, irradiation induced similar alterations in villus height and crypt cell proliferation in the jejunum of WT and APN KO mice. Jejunum explants from sham-irradiated APN KO mice produced higher levels of IL-6 compared with tissue from WT animals, but the difference was no longer apparent following irradiation. Our data indicate that APN deficiency does not play a significant role in modulating radiation-induced gastrointestinal injury in mice, while it may participate in regulation of damage to the hematopoietic system.

  13. Reduction Levels and the Effects of High-Molecular-Weight Adiponectin via AMPK/eNOS in Chinese Type 2 Diabetes.

    Science.gov (United States)

    Lian, K; Guo, X; Huang, Q; Tan, Z; Xia, C; Wang, R; Yi, F; Li, W; Liu, J; Li, Y; Guo, S; Wang, H; Ji, Q; Tao, L

    2016-10-01

    Aim: This study was to investigate the change of high-molecula-weight (HMW) adiponectin (APN) isoform, the association between type 2 diabetes mellitus (T2DM) and HMW APN isoform, the variation of Disulfide-bond A oxidoreductase-like protein (DsbA-L), the effect of HMW APN isoform on AMP-dependent protein kinase (AMPK) and endothelial nitric oxide synthase (eNOS) in Chinese T2DM. Method: 169 patients aged at (48.7±9.4) years and 107 healthy control subjects aged at (42.6±7.8) years took part in this study. Anthropometric measures of the characters were assayed and different APN isoforms, DsbA-L, AMPK and eNOS levels were determined. Results: Ln(sRAGE) and Ln(Adiponectin) were significantly lower and significantly higher for the other characteristics in T2DM. Ln(Adiponectin) was negatively and significantly correlated with WHR, Ln(triglycerides), fasting plasma glucose, HbA1c (%) in control subjects and T2DM patients. Plasma and adipose tissue total APN and HMW APN were significantly reduced in newly diagnosed T2DM patients. DsbA-L was markedly down-regulated in diabetic adipose tissue. HMW APN caused significant decreases in AMPK and eNOS phosphorylation levels of human umbilical vein endothelial cells (HUVECs). Conclusions: Our results demonstrated that total APN levels was closely related to the risk of T2DM and HMW APN reduction was involved in the diabetic vascular AMPK/eNOS signal pathway. The findings will provide insight into novel therapeutic approaches for reducing the elevated cardiovascular risk associated with T2DM. © Georg Thieme Verlag KG Stuttgart · New York.

  14. Aminopeptidase N/CD13 as a Potential Therapeutic Target in Malignant Pleural Mesothelioma.

    Science.gov (United States)

    Otsuki, Takahiko; Nakashima, Taku; Hamada, Hironobu; Takayama, Yusuke; Akita, Shin; Masuda, Takeshi; Horimasu, Yasushi; Miyamoto, Shintaro; Iwamoto, Hiroshi; Fujitaka, Kazunori; Miyata, Yoshihiro; Miyake, Masayuki; Kohno, Nobuoki; Okada, Morihito; Hattori, Noboru

    2018-03-08

    Angiogenesis is a crucial factor in the progression of malignant pleural mesothelioma (MPM), and antiangiogenic strategies might be effective against MPM. Aminopeptidase N/CD13 (APN/CD13) promotes tumour angiogenesis and is associated with poor prognosis; however, its clinical significance in MPM remains unclear.In 37 consecutive patients with surgically resected MPM, we evaluated the association between immunohistochemical APN/CD13 expression in resected tumours and survival. Additionally, the antitumour and antiangiogenic effects of MT95-4, a fully humanized anti-APN/CD13 monoclonal antibody, were evaluated in mice orthotopically implanted with EHMES-10 (abundantly expressing APN/CD13) and MSTO-211H (scarcely expressing APN/CD13) MPM cells.High tumour APN/CD13 expression was associated with poor prognosis in MPM patients ( P =0.04), and MT95-4 treatment reduced tumour growth and angiogenesis in mice harbouring EHMES-10, but not MSTO-211H, cells. Furthermore, in mice harbouring EHMES-10 cells, MT95-4 combined with cisplatin more effectively suppressed tumour progression than cisplatin alone.Taken together these results suggested that APN/CD13 is implicated in the aggressiveness of MPM. Here, MT95-4 treatment reduced tumour progression likely by inhibiting angiogenesis, suggesting APN/CD13 as a potential molecular target for MPM treatment. Additionally, combination treatment with MT95-4 and cisplatin could represent a promising approach to treating MPM exhibiting high APN/CD13 expression. Copyright ©ERS 2018.

  15. Mentoring advanced practice nurses in research: recommendations from a pilot program.

    Science.gov (United States)

    Leung, Doris; Widger, Kimberley; Howell, Doris; Nelson, Sioban; Molassiotis, Alex

    2012-01-01

    Advanced Practice Nurses (APNs) need research skills to develop and advance their practice and, yet, many have limited access to research training and support following completion of their advanced degree. In this paper we report on the development, delivery, and evaluation of an innovative pilot program that combined research training and one-to-one mentorship for nine APNs in conducting research relevant to their practice. The program was organized within an academic institution and its affiliated hospitals in Toronto, Canada. Our experience with this program may assist those in other organizations to plan and deliver a similar program for APN research mentorship.

  16. Globular Adiponectin Inhibits the Apoptosis of Mesenchymal Stem Cells Induced by Hypoxia and Serum Deprivation via the AdipoR1-Mediated Pathway

    OpenAIRE

    Xia-Qiu Tian; Yue-Jin Yang; Qing Li; Pei-Sen Huang; Xiang-Dong Li; Chen Jin; Kang Qi; Lei-Pei Jiang; Gui-Hao Chen

    2016-01-01

    Background/Aims: Poor viability of transplanted mesenchymal stem cells (MSCs) within the ischemic heart limits their therapeutic potential for cardiac repair. Globular adiponectin (gAPN) exerts anti-apoptotic effects on several types of stem cells. Herein, we investigated the effect of gAPN on the MSCs against apoptosis induced by hypoxia and serum deprivation (H/SD). Methods: MSCs exposed to H/SD conditions were treated with different concentrations of gAPN. To identify the main type of rece...

  17. Adiponectin attenuates lung fibroblasts activation and pulmonary fibrosis induced by paraquat.

    Directory of Open Access Journals (Sweden)

    Rong Yao

    Full Text Available Pulmonary fibrosis is one of the most common complications of paraquat (PQ poisoning, which demands for more effective therapies. Accumulating evidence suggests adiponectin (APN may be a promising therapy against fibrotic diseases. In the current study, we determine whether the exogenous globular APN isoform protects against pulmonary fibrosis in PQ-treated mice and human lung fibroblasts, and dissect the responsible underlying mechanisms. BALB/C mice were divided into control group, PQ group, PQ + low-dose APN group, and PQ + high-dose APN group. Mice were sacrificed 3, 7, 14, and 21 days after PQ treatment. We compared pulmonary histopathological changes among different groups on the basis of fibrosis scores, TGF-β1, CTGF and α-SMA pulmonary content via Western blot and real-time quantitative fluorescence-PCR (RT-PCR. Blood levels of MMP-9 and TIMP-1 were determined by ELISA. Human lung fibroblasts WI-38 were divided into control group, PQ group, APN group, and APN receptor (AdipoR 1 small-interfering RNA (siRNA group. Fibroblasts were collected 24, 48, and 72 hours after PQ exposure for assay. Cell viability and apoptosis were determined via Kit-8 (CCK-8 and fluorescein Annexin V-FITC/PI double labeling. The protein and mRNA expression level of collagen type III, AdipoR1, and AdipoR2 were measured by Western blot and RT-PCR. APN treatment significantly decreased the lung fibrosis scores, protein and mRNA expression of pulmonary TGF-β1, CTGF and α-SMA content, and blood MMP-9 and TIMP-1 in a dose-dependent manner (p<0.05. Pretreatment with APN significantly attenuated the reduced cell viability and up-regulated collagen type III expression induced by PQ in lung fibroblasts, (p<0.05. APN pretreatment up-regulated AdipoR1, but not AdipoR2, expression in WI-38 fibroblasts. AdipoR1 siRNA abrogated APN-mediated protective effects in PQ-exposed fibroblasts. Taken together, our data suggests APN protects against PQ-induced pulmonary fibrosis in a

  18. Plasma Adiponectin, clinical factors, and patient outcomes during the acute respiratory distress syndrome.

    Directory of Open Access Journals (Sweden)

    Allan J Walkey

    Full Text Available Adiponectin (APN is an anti-inflammatory hormone derived from adipose tissue that attenuates acute lung injury in rodents. In this study, we investigated the association between circulating APN and outcomes among patients with acute respiratory distress syndrome (ARDS.We performed a retrospective cohort study using data and plasma samples from participants in the multicenter ARDS Network Fluid and Catheter Treatment Trial.Plasma APN concentrations were measured in 816 (81.6% trial participants at baseline and in 568 (56.8% subjects at both baseline and day 7 after enrollment. Clinical factors associated with baseline APN levels in multivariable-adjusted models included sex, body mass index, past medical history of cirrhosis, and central venous pressure (model R2 = 9.7%. We did not observe an association between baseline APN and either severity of illness (APACHE III or extent of lung injury (Lung Injury Score. Among patients who received right heart catheterization (n = 384, baseline APN was inversely related to mean pulmonary artery pressure (β = -0.015, R2 1.5%, p = 0.02; however, this association did not persist in multivariable models (β = -0.009, R2 0.5%, p = 0.20. Neither baseline APN levels [HR per quartile1.04 (95% CI 0.91-1.18, p = 0.61], nor change in APN level from baseline to day 7 [HR 1.04 (95% CI 0.89-1.23, p = 0.62] were associated with 60 day mortality in Cox proportional hazards regression models. However, subgroup analysis identified an association between APN and mortality among patients who developed ARDS from extra-pulmonary etiologies [HR per quartile 1.31 (95% CI 1.08-1.57]. APN levels did not correlate with mortality among patients developing ARDS in association with direct pulmonary injury [HR 0.96 (95% CI 0.83-1.13], pinteraction = 0.016.Plasma APN levels did not correlate with disease severity or mortality in a large cohort of patients with ARDS. However, higher APN levels were

  19. Doctor of Nursing Practice: The Role of the Advanced Practice Nurse.

    Science.gov (United States)

    Walker, Deborah Kirk; Polancich, Shea

    2015-11-01

    To explore the evolution and emerging roles of the Doctor of Nursing Practice (DNP) Advanced Practice Nurse (APN). Published peer reviewed literature, cancer-related professional resources, and Web-based resources. The DNP education has prepared the APN for process improvement initiatives, providing quality care, and evidence-based practice translation, which are critical with the emerging trends in this complex health care environment. DNP-prepared APNs have the opportunity to impact oncology care across the cancer trajectory, in various settings, and in various innovative roles as entrepreneurs. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. Abnormal Origin and Course of the Accessory Phrenic Nerve: Case Report.

    Science.gov (United States)

    Paraskevas, George; Koutsouflianiotis, Konstantinos; Kitsoulis, Panagiotis; Spyridakis, Ioannis

    In the current cadaveric study an unusual sizeable accessory phrenic nerve (APN) was encountered emerging from the trunk of the supraclavicular nerves and forming a triangular loop that was anastomosing with the phrenic nerve. That neural loop surrounded the superficial cervical artery which displayed a spiral course. The form of a triangular loop of APN involving the aforementioned artery and originating from the supraclavicular nerve to the best of our knowledge has not been documented previously in the literature. The variable morphological features of the APN along with its clinical applications are briefly discussed.

  1. Abnormal Origin and Course of the Accessory Phrenic Nerve: Case Report

    Directory of Open Access Journals (Sweden)

    George Paraskevas

    2016-08-01

    Full Text Available In the current cadaveric study an unusual sizeable accessory phrenic nerve (APN was encountered emerging from the trunk of the supraclavicular nerves and forming a triangular loop that was anastomosing with the phrenic nerve. That neural loop surrounded the superficial cervical artery which displayed a spiral course. The form of a triangular loop of APN involving the aforementioned artery and originating from the supraclavicular nerve to the best of our knowledge has not been documented previously in the literature. The variable morphological features of the APN along with its clinical applications are briefly discussed.

  2. 99mTc-DMSA scintigraphy in acute urinary tract infection in children

    International Nuclear Information System (INIS)

    Verboven, M.; Ingels, M.; Delree, M.; Piepsz, A.; Vrije Univ., Brussels

    1990-01-01

    24 children with symptomatic urinary tract infection (UTI) underwent systematically ultrasound studies (US) and 99m Tc-DMSA renal scans. Among the 15 patients considered as acute pyelonephritis (APN) on clinical grounds, the scan was abnormal in 12 cases, in contrast with only 1 abnormal scan in the clinical subgroup of the lower UTI. Among the 10 abnormal scans that were repeated later on, 6 did completely normalize. US showed only once a parenchymal appearance suggestive for APN. Our findings suggest that the DMSA scan has to be considered at present as the most sensitive imaging technique for the detection of APN. (orig.)

  3. Clinical significance of the changes of serum IL-8 and IL-12 levels in pediatric patients with anaphylactoid purpura (AP)

    International Nuclear Information System (INIS)

    Liang Zhenming; Liu Xia

    2005-01-01

    Objective: To explore the role of IL-8 and IL-12 in the pathogenesis of anaphylactoid purpura (AP) and anaphylactoid purpura nephritis (APN). Methods: Serum IL-8 (with RIA) and IL-12 (with ELISA) levels were measured in 32 pediatric patients with anaphylactoid purpura (AP), 11 pediatric patients with anaphylactoid purpura nephritis (APN) and 15 controls. Results: During acute stage, serum IL-8 and IL-12 levels in both the AP and APN patients were significantly higher than those in controls and remained higher during convalescence. IL-8 and IL-12 levels were mutually positively correlated in acute stage. Conclusion: IL-8 and IL-12 participated in the pathogenesis of AP and APN. Theoretically, antagonist to those cytokines might be of clinical benefits. (authors)

  4. Nursing: What's a Nurse Practitioner?

    Science.gov (United States)

    ... as advanced practice nurses, or APNs) have a master's degree in nursing (MS or MSN) and board certification ... NP training emphasizes disease prevention, reduction of health risks, and thorough patient education. Like doctors, NPs are ...

  5. Advanced practice nurses core competencies: a framework for developing and testing an advanced practice nurse discharge intervention.

    Science.gov (United States)

    Cooke, Liz; Gemmill, Robin; Grant, Marcia

    2008-01-01

    The purpose of this paper was to describe evidenced-based interventions as implemented by advanced practice nurses (APNs) conducting intervention research with a vulnerable population of blood and marrow transplant patients. In addition, each of the 6 core competencies of the APN role identified by Hamric are outlined and applied using a patient case study. These competencies are the following: direct clinical practice, expert coaching and advice, consultation, research skills, clinical and professional leadership, collaboration, and ethical decision making. This article chronicles a typical patient's journey through a post-hospital discharge nursing research study involving APNs as "intervention nurses" and discusses the various aspects of the APN core competencies throughout the process.

  6. Sequential injection chemiluminescence immunoassay for nonionic surfactants by using magnetic microbeads

    International Nuclear Information System (INIS)

    Zhang Ruiq; Nakajima, Hizuru; Soh, Nobuaki; Nakano, Koji; Masadome, Takashi; Nagata, Kazumi; Sakamoto, Kazuhira; Imato, Toshihiko

    2007-01-01

    A rapid and sensitive immunoassay based on a sequential injection analysis (SIA) using magnetic microbeads for the determination of alkylphenol polyethoxylates (APnEOs) is described. An SIA system was constructed from a syringe pump, a switching valve, a flow-through type immunoreaction cell equipped with a photon counting unit and a neodymium magnet. Magnetic beads, to which an anti-APnEOs monoclonal antibody was immobilized, were used as a solid support in an immunoassay. The introduction, trapping and release of the magnetic beads in and from the immunoreaction cell were controlled by means of a neodymium magnet and adjusting the flow of a carrier solution. The immunoassay was based on an indirect competitive immunoreaction of an anti-APnEOs monoclonal antibody immobilized on the magnetic beads with a sample APnEOs and a horseradish peroxidase (HRP)-labeled APnEOs in the same sample solution, and was based on the subsequent chemiluminscence reaction of HRP on the magnetic microbeads with a luminol solution containing hydrogen peroxide and p-iodophenol. The anti-APnEOs antibody was immobilized on the magnetic microbeads by coupling the antibody with the magnetic beads after activation of a carboxylate moiety on the surface of the magnetic beads that had been coated with a polylactic acid film. The antibody immobilized magnetic beads were introduced in the immunoreaction cell and trapped in it by the neodymium magnet, which was equipped beneath the immunoreaction cell. An APnEOs sample solution containing the HRP-labeled APnEOs at a constant concentration, and a luminol solution containing hydrogen peroxide and p-iodophenol were sequentially introduced into the immunoreaction cell, according to an SIA programmed sequence. Chemiluminescence emission was monitored by means of a photon counting unit located at the upper side of the immunoreaction cell by collecting the emitted light with a lens. A typical sigmoidal calibration curve was obtained, when the logarithm

  7. The Genus Wallemia—From Contamination of Food to Health Threat

    Directory of Open Access Journals (Sweden)

    Janja Zajc

    2018-05-01

    Full Text Available The fungal genus Wallemia of the order Wallemiales (Wallemiomycotina, Basidiomycota comprises the most xerotolerant, xerophilic and also halophilic species worldwide. Wallemia spp. are found in various osmotically challenged environments, such as dry, salted, or highly sugared foods, dry feed, hypersaline waters of solar salterns, salt crystals, indoor and outdoor air, and agriculture aerosols. Recently, eight species were recognized for the genus Wallemia, among which four are commonly associated with foods: W. sebi, W. mellicola, W. muriae and W. ichthyophaga. To date, only strains of W. sebi, W. mellicola and W. muriae have been reported to be related to human health problems, as either allergological conditions (e.g., farmer’s lung disease or rare subcutaneous/cutaneous infections. Therefore, this allergological and infective potential, together with the toxins that the majority of Wallemia spp. produce even under saline conditions, defines these fungi as filamentous food-borne pathogenic fungi.

  8. Adiponectin attenuates lung fibroblasts activation and pulmonary fibrosis induced by paraquat.

    Science.gov (United States)

    Yao, Rong; Cao, Yu; He, Ya-rong; Lau, Wayne Bond; Zeng, Zhi; Liang, Zong-an

    2015-01-01

    Pulmonary fibrosis is one of the most common complications of paraquat (PQ) poisoning, which demands for more effective therapies. Accumulating evidence suggests adiponectin (APN) may be a promising therapy against fibrotic diseases. In the current study, we determine whether the exogenous globular APN isoform protects against pulmonary fibrosis in PQ-treated mice and human lung fibroblasts, and dissect the responsible underlying mechanisms. BALB/C mice were divided into control group, PQ group, PQ + low-dose APN group, and PQ + high-dose APN group. Mice were sacrificed 3, 7, 14, and 21 days after PQ treatment. We compared pulmonary histopathological changes among different groups on the basis of fibrosis scores, TGF-β1, CTGF and α-SMA pulmonary content via Western blot and real-time quantitative fluorescence-PCR (RT-PCR). Blood levels of MMP-9 and TIMP-1 were determined by ELISA. Human lung fibroblasts WI-38 were divided into control group, PQ group, APN group, and APN receptor (AdipoR) 1 small-interfering RNA (siRNA) group. Fibroblasts were collected 24, 48, and 72 hours after PQ exposure for assay. Cell viability and apoptosis were determined via Kit-8 (CCK-8) and fluorescein Annexin V-FITC/PI double labeling. The protein and mRNA expression level of collagen type III, AdipoR1, and AdipoR2 were measured by Western blot and RT-PCR. APN treatment significantly decreased the lung fibrosis scores, protein and mRNA expression of pulmonary TGF-β1, CTGF and α-SMA content, and blood MMP-9 and TIMP-1 in a dose-dependent manner (ppulmonary fibrosis in a dose-dependent manner, via suppression of lung fibroblast activation. Functional AdipoR1 are expressed by human WI-38 lung fibroblasts, suggesting potential future clinical applicability of APN against pulmonary fibrosis.

  9. Critical care nurse practitioners and clinical nurse specialists interface patterns with computer-based decision support systems.

    Science.gov (United States)

    Weber, Scott

    2007-11-01

    The purposes of this review are to examine the types of clinical decision support systems in use and to identify patterns of how critical care advanced practice nurses (APNs) have integrated these systems into their nursing care patient management practices. The decision-making process itself is analyzed with a focus on how automated systems attempt to capture and reflect human decisional processes in critical care nursing, including how systems actually organize and process information to create outcome estimations based on patient clinical indicators and prognosis logarithms. Characteristics of APN clinicians and implications of these characteristics on decision system use, based on the body of decision system user research, are introduced. A review of the Medline, Ovid, CINAHL, and PubMed literature databases was conducted using "clinical decision support systems,"computerized clinical decision making," and "APNs"; an examination of components of several major clinical decision systems was also undertaken. Use patterns among APNs and other clinicians appear to vary; there is a need for original research to examine how APNs actually use these systems in their practices in critical care settings. Because APNs are increasingly responsible for admission to, and transfer from, critical care settings, more understanding is needed on how they interact with this technology and how they see automated decision systems impacting their practices. APNs who practice in critical care settings vary significantly in how they use the clinical decision systems that are in operation in their practice settings. These APNs must have an understanding of their use patterns with these systems and should critically assess whether their patient care decision making is affected by the technology.

  10. The combination of urinary IL - 6 and renal biometry as useful diagnostic tools to differentiate acute pyelonephritis from lower urinary tract infection

    Directory of Open Access Journals (Sweden)

    Sherif Azab

    Full Text Available ABSTRACT Objective: To evaluate the role of renal ultrasound (RUS and urinary IL-6 in the differentiation between acute pyelonephritis (APN and lower urinary tract infection (LUTI. Patients and methods: This prospective study was carried out at the Pediatric and urology outpatient and inpatient departments of Cairo University Children's Hospital as well as October 6 University Hospital and it included 155 children between one month and fourteen years old with positive culture UTI. Patients were categorized into APN and LUTI based on their clinical features and laboratory parameters. Thirty healthy children, age and sex matched constituted the control group. Children with positive urine cultures were treated with appropriate antibiotics. Before treatment, urinary IL-6 was measured by enzyme immunoassay technique (ELISA, and renal ultrasound (RUS was done. CRP (C-reactive protein, IL-6 and RUS were repeated on the 14th day of antibiotic treatment to evaluate the changes in their levels in response to treatment. Results: UIL-6 levels were more significantly higher in patients with APN than in patients with LUTI (24.3±19.3pg/mL for APN vs. 7.3±2.7pg/mL in LUTI (95% CI: 2.6-27.4; p20pg/mL and serum CRP >20μg/mL were highly reliable markers of APN. Mean renal volume and mean volume difference between the two kidneys in the APN group were more than that of the LUTI and control groups (P<0.001. Renal volume between 120-130% of normal was the best for differentiating APN from LUTI. Conclusions: RUS and urinary IL-6 levels have a highly dependable role in the differentiation between APN and LUTI especially in places where other investigations are not available and/ or affordable.

  11. Identification of Hypertension Management-related Errors in a Personal Digital Assistant-based Clinical Log for Nurses in Advanced Practice Nurse Training

    Directory of Open Access Journals (Sweden)

    Nam-Ju Lee, DNSc, RN

    2010-03-01

    Conclusion: The Hypertension Diagnosis and Management Error Taxonomy was useful for identifying errors based on documentation in a clinical log. The results provide an initial understanding of the nature of errors associated with hypertension diagnosis and management of nurses in APN training. The information gained from this study can contribute to educational interventions that promote APN competencies in identification and management of hypertension as well as overall patient safety and informatics competencies.

  12. Commentary: Taking the Pulse on the Integration of the Clinical Nurse Specialist Role in Canada.

    Science.gov (United States)

    Roussel, Josette

    2016-01-01

    The Canadian Nurses Association (CNA) is pleased to provide this update on the integration of the clinical nurse specialist (CNS) role in Canada. Many advances have occurred since the publication of the Canadian Journal of Nursing Leadership special issue focused on advanced practice nursing (APN) in 2010. The CNA continues to promote and advance this APN role, and views the CNS as an essential and critical role for better care to Canadians.

  13. Plasma neutrophil gelatinase-associated lipocalin: a marker of acute pyelonephritis in children.

    Science.gov (United States)

    Kim, Byung Kwan; Yim, Hyung Eun; Yoo, Kee Hwan

    2017-03-01

    This study was designed to compare the diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin (NGAL) with procalcitonin (PCT), C-reactive protein (CRP), and white blood cells (WBCs) for predicting acute pyelonephritis (APN) in children with febrile urinary tract infections (UTIs). In total, 138 children with febrile UTIs (APN 59, lower UTI 79) were reviewed retrospectively. Levels of NGAL, PCT, CRP, and WBCs in blood were measured on admission. The diagnostic accuracy of the biomarkers was investigated. Independent predictors of APN were identified by multivariate logistic regression analysis. Receiver operating curve (ROC) analyses showed good diagnostic profiles of NGAL, PCT, CRP, and WBCs for identifying APN [area under the curve (AUC) 0.893, 0.855, 0.879, and 0.654, respectively]. However, multivariate analysis revealed only plasma NGAL level was an independent predictor of APN (P = 0.006). At the best cutoff values of all examined biomarkers for identifying APN, sensitivity (86 %), specificity (85 %), positive predictive value (81 %), and negative predictive value (89 %) of plasma NGAL levels were the highest. The optimal NGAL cutoff value was 117 ng/ml. The positive likelihood ratio [odds ratio (OR) 5.69, 95 % confidence interval (CI) 3.56-8.78], and negative likelihood ratio (OR 0.16, 95 % CI 0.08-0.29) of plasma NGAL for APN diagnosis also showed it seemed to be more accurate than serum PCT, CRP, and WBCs. Plasma NGAL can be more useful than serum PCT, CRP, and WBC levels for identifying APN in children with febrile UTIs.

  14. Association of Adiponectin With Cancer and All-Cause Mortality in a Japanese Community-Dwelling Elderly Cohort: A Case-Cohort Study.

    Science.gov (United States)

    Kojima, Reiji; Ukawa, Shigekazu; Zhao, Wenjing; Suzuki, Koji; Yamada, Hiroya; Tsushita, Kazuyo; Kawamura, Takashi; Okabayashi, Satoe; Wakai, Kenji; Noma, Hisashi; Ando, Masahiko; Tamakoshi, Akiko

    2018-03-24

    Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on cardiovascular disease, but data on the relationship between plasma APN and cancer mortality is exiguous. We investigated whether APN is associated with cancer mortality in community-dwelling elderly people. We conducted a case-cohort study within the New Integrated Suburban Seniority Investigation (NISSIN) Project using a randomly drawn sub-cohort of 697 subjects (351 men and 346 women; mean age 64.5 [standard deviation, 0.5] years) among whom we compared cases of all-cause death (n = 269) and cancer death (n = 149) during a mean follow-up duration of 10.8 (standard deviation, 3.7) years. Associations between APN and mortality were assessed using weighted Cox regression analyses. We observed significant positive associations between the APN concentration and cancer death in the first and third APN tertiles compared with the second APN tertile (hazard ratio [HR] T1 vs T2 , 1.67; 95% confidence interval [CI], 1.00-2.79 and HR T3 vs T2 , 2.10; 95% CI, 1.30-3.40). Further adjustment for possible confounders attenuated the association (HR T1 vs T2 , 1.63; 95% CI, 0.93-2.84 and HR T3 vs T2 , 2.10; 95% CI, 1.26-3.50). A similar but weaker association was seen for all-cause mortality (multivariate HR T1 vs T2 , 1.45; 95% CI, 0.95-2.21 and HR T3 vs T2 , 1.51; 95% CI, 1.01-2.25). Plasma APN and cancer mortality have a significant relationship among community-dwelling elderly people, which warrants further study.

  15. Porcine aminopeptidase N mediated polarized infection by porcine epidemic diarrhea virus in target cells

    Energy Technology Data Exchange (ETDEWEB)

    Cong, Yingying; Li, Xiaoxue; Bai, Yunyun [College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030 (China); Lv, Xiaonan [College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030 (China); CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience & Technology of China, Beijing 100090 (China); Herrler, Georg [Institute for Virology, University of Veterinary Medicine, Hannover D-30559 (Germany); Enjuanes, Luis [Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Cantoblanco, Madrid (Spain); Zhou, Xingdong [College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030 (China); Qu, Bo [Faculty of Life Sciences, Northeast Agricultural University, Harbin 150030 (China); Meng, Fandan [Institute for Virology, University of Veterinary Medicine, Hannover D-30559 (Germany); Cong, Chengcheng [College Animal Husbandry and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110161 (China); Ren, Xiaofeng; Li, Guangxing [College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030 (China)

    2015-04-15

    Infection of polarized intestinal epithelial cells by porcine epidemic diarrhea virus (PEDV) was characterized. Indirect immunofluorescence assay, real-time PCR, and transmission electron microscopy confirmed PEDV can be successfully propagated in immortalized swine small intestine epithelial cells (IECs). Infection involved porcine aminpeptidase N (pAPN), a reported cellular receptor for PEDV, transient expression of pAPN and siRNA targeted pAPN increased and decreased the infectivity of PEDV in IECs, respectively. Subsequently, polarized entry into and release from both Vero E6 and IECs was analyzed. PEDV entry into polarized cells and pAPN grown on membrane inserts occurs via apical membrane. The progeny virus released into the medium was also quantified which demonstrated that PEDV is preferentially released from the apical membrane. Collectively, our data demonstrate that pAPN, the cellular receptor for PEDV, mediates polarized PEDV infection. These results imply the possibility that PEDV infection may proceed by lateral spread of virus in intestinal epithelial cells. - Highlights: • PEDV infection of polarized intestinal epithelial cells (IECs) was characterized. • Porcine aminpeptidase N (pAPN) facilitated PEDV infection in IECs. • PEDV entry into and release from polarized cell via its apical membrane. • PEDV infection may proceed by lateral spread of virus in IECs.

  16. Binding determinants in the interplay between porcine aminopeptidase N and enterotoxigenic Escherichia coli F4 fimbriae.

    Science.gov (United States)

    Xia, Pengpeng; Quan, Guomei; Yang, Yi; Zhao, Jing; Wang, Yiting; Zhou, Mingxu; Hardwidge, Philip R; Zhu, Jianzhong; Liu, Siguo; Zhu, Guoqiang

    2018-02-26

    The binding of F4 + enterotoxigenic Escherichia coli (ETEC) and the specific receptor on porcine intestinal epithelial cells is the initial step in F4 + ETEC infection. Porcine aminopeptidase N (APN) is a newly discovered receptor for F4 fimbriae that binds directly to FaeG adhesin, which is the major subunit of the F4 fimbriae variants F4ab, F4ac, and F4ad. We used overlapping peptide assays to map the APN-FaeG binding sites, which has facilitated in the identifying the APN-binding amino acids that are located in the same region of FaeG variants, thereby limiting the major binding regions of APN to 13 peptides. To determine the core sequence motif, a panel of FaeG peptides with point mutations and FaeG mutants were constructed. Pull-down and binding reactivity assays using piglet intestines determined that the amino acids G159 of F4ab, N209 and L212 of F4ac, and A200 of F4ad were the critical residues for APN binding of FaeG. We further show using ELISA and confocal microscopy assay that amino acids 553-568, and 652-670 of the APN comprise the linear epitope for FaeG binding in all three F4 fimbriae variants.

  17. Association of procalcitonin with acute pyelonephritis and renal scars in pediatric UTI.

    Science.gov (United States)

    Leroy, Sandrine; Fernandez-Lopez, Anna; Nikfar, Roya; Romanello, Carla; Bouissou, François; Gervaix, Alain; Gurgoze, Metin K; Bressan, Silvia; Smolkin, Vladislav; Tuerlinckx, David; Stefanidis, Constantinos J; Vaos, Georgos; Leblond, Pierre; Gungor, Firat; Gendrel, Dominique; Chalumeau, Martin

    2013-05-01

    Urinary tract infections (UTIs) are common childhood bacterial infections that may involve renal parenchymal infection (acute pyelonephritis [APN]) followed by late scarring. Prompt, high-quality diagnosis of APN and later identification of children with scarring are important for preventing future complications. Examination via dimercaptosuccinic acid scanning is the current clinical gold standard but is not routinely performed. A more accessible assay could therefore prove useful. Our goal was to study procalcitonin as a predictor for both APN and scarring in children with UTI. A systematic review and meta-analysis of individual patient data were performed; all data were gathered from children with UTIs who had undergone both procalcitonin measurement and dimercaptosuccinic acid scanning. A total of 1011 patients (APN in 60.6%, late scarring in 25.7%) were included from 18 studies. Procalcitonin as a continuous, class, and binary variable was associated with APN and scarring (P children who had APN during the early stages of UTI, as well as those with late scarring.

  18. Mechanisms for the inversion of chirality: Global reaction route mapping of stereochemical pathways in a probable chiral extraterrestrial molecule, 2-aminopropionitrile

    International Nuclear Information System (INIS)

    Kaur, Ramanpreet; Vikas

    2015-01-01

    2-Aminopropionitrile (APN), a probable candidate as a chiral astrophysical molecule, is a precursor to amino-acid alanine. Stereochemical pathways in 2-APN are explored using Global Reaction Route Mapping (GRRM) method employing high-level quantum-mechanical computations. Besides predicting the conventional mechanism for chiral inversion that proceeds through an achiral intermediate, a counterintuitive flipping mechanism is revealed for 2-APN through chiral intermediates explored using the GRRM. The feasibility of the proposed stereochemical pathways, in terms of the Gibbs free-energy change, is analyzed at the temperature conditions akin to the interstellar medium. Notably, the stereoinversion in 2-APN is observed to be more feasible than the dissociation of 2-APN and intermediates involved along the stereochemical pathways, and the flipping barrier is observed to be as low as 3.68 kJ/mol along one of the pathways. The pathways proposed for the inversion of chirality in 2-APN may provide significant insight into the extraterrestrial origin of life

  19. Childhood acute pyelonephritis: comparison of power Doppler sonography and Tc-DMSA scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Stogianni, Aggeliki; Oikonomou, Ippoliti; Dimitriadis, Athanasios [Aristotle University of Thessaloniki, Department of Radiology, AHEPA Hospital, Thessaloniki (Greece); Nikolopoulos, Panagiotis [424 Army Hospital, Department of Radiology, Thessaloniki (Greece); Gatzola, Magdalini [Aristotle University of Thessaloniki, 2nd Paediatric Clinic, AHEPA Hospital, Thessaloniki (Greece); Balaris, Vassilios [Aristotle University of Thessaloniki, Department of Nuclear Medicine, AHEPA Hospital, Thessaloniki (Greece); Farmakiotis, Dimitrios [Infectious Diseases Hospital of Thessaloniki, Department of Medicine, Thessaloniki (Greece)

    2007-07-15

    Tc 99m DMSA scintigraphy is regarded as the gold standard for the detection and localization of acute pyelonephritis (APN) in children. Power Doppler sonography (PD US) is a radiation-free and cost-effective technique that could be useful in the diagnosis of APN in children. To compare the predictive value of PD US with DMSA scintigraphy in the diagnosis of APN in children. A total of 74 neonates and children with clinical findings consistent with possible upper urinary tract infection were evaluated with PD US and DMSA scintigraphy. Children with anatomic (grey-scale) abnormalities were excluded. A total of 147 kidneys were examined within the first 48 h after the onset of symptoms. Each kidney was divided into three zones (upper, middle, and lower third). APN was diagnosed by PD US in 46 kidneys. Sensitivity and specificity for detecting APN using DMSA scintigraphy as the reference standard were 73.8% and 85.7%, respectively. There was good agreement between PD US and DMSA scintigraphy in the localization of lesions. In clinically suspected APN, PD US has acceptable specificity and sensitivity, if performed within the first 48 h and could be helpful in neonates and children under 3 months of age in whom the use of scintigraphy is generally discouraged. (orig.)

  20. Porcine aminopeptidase N mediated polarized infection by porcine epidemic diarrhea virus in target cells

    International Nuclear Information System (INIS)

    Cong, Yingying; Li, Xiaoxue; Bai, Yunyun; Lv, Xiaonan; Herrler, Georg; Enjuanes, Luis; Zhou, Xingdong; Qu, Bo; Meng, Fandan; Cong, Chengcheng; Ren, Xiaofeng; Li, Guangxing

    2015-01-01

    Infection of polarized intestinal epithelial cells by porcine epidemic diarrhea virus (PEDV) was characterized. Indirect immunofluorescence assay, real-time PCR, and transmission electron microscopy confirmed PEDV can be successfully propagated in immortalized swine small intestine epithelial cells (IECs). Infection involved porcine aminpeptidase N (pAPN), a reported cellular receptor for PEDV, transient expression of pAPN and siRNA targeted pAPN increased and decreased the infectivity of PEDV in IECs, respectively. Subsequently, polarized entry into and release from both Vero E6 and IECs was analyzed. PEDV entry into polarized cells and pAPN grown on membrane inserts occurs via apical membrane. The progeny virus released into the medium was also quantified which demonstrated that PEDV is preferentially released from the apical membrane. Collectively, our data demonstrate that pAPN, the cellular receptor for PEDV, mediates polarized PEDV infection. These results imply the possibility that PEDV infection may proceed by lateral spread of virus in intestinal epithelial cells. - Highlights: • PEDV infection of polarized intestinal epithelial cells (IECs) was characterized. • Porcine aminpeptidase N (pAPN) facilitated PEDV infection in IECs. • PEDV entry into and release from polarized cell via its apical membrane. • PEDV infection may proceed by lateral spread of virus in IECs

  1. The Role of Serum Adiponectin for Outcome Prediction in Patients with Dilated Cardiomyopathy and Advanced Heart Failure

    Directory of Open Access Journals (Sweden)

    Vaida Baltrūnienė

    2017-01-01

    Full Text Available Clinical interpretation of patients’ plasma adiponectin (APN remains challenging; its value as biomarker in dilated cardiomyopathy (DCM is equivocal. We evaluated whether circulating APN level is an independent predictor of composite outcome: death, left ventricle assist device (LVAD implantation, and heart transplantation (HT in patients with nonischemic DCM. 57 patients with nonischemic DCM (average LV diastolic diameter 6.85 cm, LV ejection fraction 26.63%, and pulmonary capillary wedge pressure 22.06  mmHg were enrolled. Patients underwent echocardiography, right heart catheterization, and endomyocardial biopsy. During a mean follow-up of 33.42 months, 15 (26% patients died, 12 (21% patients underwent HT, and 8 (14% patients were implanted with LVAD. APN level was significantly higher in patients who experienced study endpoints (23.4 versus 10.9 ug/ml, p=0.01. APN was associated with worse outcome in univariate Cox proportional hazards model (HR 1.04, CI 1.02–1.07, p=0.001 but lost significance adjusting for other covariates. Average global strain (AGS is an independent outcome predictor (HR 1.42, CI 1.081–1.866, p=0.012. Increased circulating APN level was associated with higher mortality and may be an additive prognostic marker in DCM with advanced HF. Combination of serum (APN, BNP, TNF-α and echocardiographic (AGS markers may increase the HF predicting power for the nonischemic DCM patients.

  2. Identifikasi Secara Serologi Galur Virus Flu Burung Subtipe H5N1 Clade 2.1.3 dan Clade 2.3.2 pada Ayam Petelur (SEROLOGICAL IDENTIFICATION OF AVIAN INFLUENZA STRAIN VIRUS SUBTYPE H5N1 CLADE 2.1.3 AND CLADE 2.3.2 FROM LAYER

    Directory of Open Access Journals (Sweden)

    Aprilia Kusumastuti

    2015-10-01

    Full Text Available The aim of the study was to know avian influenza (AI infection in field by using serology test in threemarketing area of AI vaccines. Haemagglutination inhibition methode was used in this test. There werefour antigen strains of AI subtype H5N1 clade 2.1.3 (AIstrainA/Chicken/West Java/PWT-WIJ/2006, AIstrain A/Chicken/Garut/BBVW-223/2007, AI strain A/Chicken/West Java-Nagrak/30/2007, and AI strainA/Chicken/Pekalongan/BBVW-208/2007 and 2 antigen strains of AI subtype H5N1 clade 2.3.2 (AI strainA/duck/Sukoharjo/BBVW-1428-9/2012 and AI strain A/duck/Sleman/BBVW-1463-10/2012 was used inthis study for HI test. The result presents that 93,33% chicken farms in three marketing area of PT. SanbioLaboratories have positive antibody titre to AI subtype H5N1 clade 2.1.3. This titre may be obtained fromAI clade 2.1.3 vaccination. From 15 samples, 92,86% are positive to AI subtype H5N1 clade 2.3.2A/duck/Sukoharjo/BBVW-1428-9/2012 and 92,31% are positive to A/duck/Sleman/BBVW-1463-10/2012 evenwithout AI clade 2.3.2 vaccination. This antibody titre may be obtained from AI clade 2.1.3 vaccine crossprotection or field infection.

  3. PENGARUH KEPEMIMPINAN KEPALA SEKOLAH DAN KOMUNIKASI INTERNAL TERHADAP EFEKTIVITAS KERJA GURU SMK PGRI WONOASRI

    Directory of Open Access Journals (Sweden)

    Ajeng Marga Kusuma

    2017-04-01

    Hasil penelitian menunjukkan 1 ada pengaruh secara parsial kepemimpinan Kepala Sekolah terhadap Efektivitas Kerja Guru SMK PGRI Wonoasri, 2 ada pengaruh secara parsial  komunikasi internal terhadap Efektivitas Kerja Guru SMK PGRI Wonoasri, 3 Ada Pengaruh secara simultan kepemimpinan Kepala Sekolah dan komunikasi internal terhadap efektivitas kerja guru SMK PGRI Wonoasri

  4. Pengaruh Bauran Pemasaran terhadap Persepsi Konsumen dalam Penciptaan Ekuitas Merek: Studi Kasus Restoran Clemmons Bandung Indah Plaza

    OpenAIRE

    Danil, Lilian

    2016-01-01

    Penulis mengajukan suatu kerangka kerja dimana persepsi konsumen atas bauran pemasaran dihubungkan dengan dimensi-dimensi ekuitas merek yaitu persepsi kualitas, loyalitas merek dan asosiasi merek yang dikombinasikan dengan kesadaran merek. Hasil penelitian menunjukkan bahwa persepsi konsumen atas bauran pemasaran dan dimensi ekuitas merek secara signifikan mempengaruhi ekuitas merek secara keseluruhan baik secara simultan maupun parsial, terhadap Brand Equity kecuali Store Image terhadap Bran...

  5. Pengaruh Service Quality Terhadap Customer Satisfication English First Surabaya Town Square

    OpenAIRE

    Prabowo, Randy Setio

    2017-01-01

    Tujuan dari penelitian ini adalah untuk menganalisa pengaruh service quality terhadap customer satisficationdan mengukur apakah memiliki pengaruh antara service quality terhadap customer satisfication baik secara stimultan maupun parsial.Hasil penelitian menunjukan bahwa service quality berpengaruh terhadap customer satisfication secara stilmultan dan secara parsial menunjukan bahwa variabel reliability dan responsiveness tidak memiliki pengaruh terhadap customer satisfication.

  6. Diagnostic performance of procalcitonin for hospitalised children with acute pyelonephritis presenting to the paediatric emergency department.

    Science.gov (United States)

    Chen, Shan-Ming; Chang, Hung-Ming; Hung, Tung-Wei; Chao, Yu-Hua; Tsai, Jeng-Dau; Lue, Ko-Huang; Sheu, Ji-Nan

    2013-05-01

    Urinary tract infection (UTI) is a common bacterial infection in children that can result in permanent renal damage. This study prospectively assessed the diagnostic performance of procalcitonin (PCT) for predicting acute pyelonephritis (APN) among children with febrile UTI presenting to the paediatric emergency department (ED). Children aged ≤10 years with febrile UTI admitted to hospital from the paediatric ED were prospectively studied. Blood PCT, C reactive protein (CRP) and white blood cell (WBC) count were measured in the ED. Sensitivity, specificity, predictive values, multilevel likelihood ratios, receiver operating characteristic (ROC) curve analysis and multivariate logistic regression were used to assess quantitative variables for diagnosing APN. The 136 enrolled patients (56 boys and 80 girls; age range 1 month to 10 years) were divided into APN (n=87) and lower UTI (n=49) groups according to (99m)Tc-dimercaptosuccinic acid scan results. The cut-off value for maximum diagnostic performance of PCT was 1.3 ng/ml (sensitivity 86.2%, specificity 89.8%). By multivariate regression analysis, only PCT and CRP were retained as significant predictors of APN. Comparing ROC curves, PCT had a significantly greater area under the curve than CRP, WBC count and fever for differentiating between APN and lower UTI. PCT has better sensitivity and specificity than CRP and WBC count for distinguishing between APN and lower UTI. PCT is a valuable marker for predicting APN in children with febrile UTI. It may be considered in the initial investigation and therapeutic strategies for children presenting to the ED.

  7. Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies.

    Directory of Open Access Journals (Sweden)

    Juan Reguera

    Full Text Available The coronaviruses (CoVs are enveloped viruses of animals and humans associated mostly with enteric and respiratory diseases, such as the severe acute respiratory syndrome and 10-20% of all common colds. A subset of CoVs uses the cell surface aminopeptidase N (APN, a membrane-bound metalloprotease, as a cell entry receptor. In these viruses, the envelope spike glycoprotein (S mediates the attachment of the virus particles to APN and subsequent cell entry, which can be blocked by neutralizing antibodies. Here we describe the crystal structures of the receptor-binding domains (RBDs of two closely related CoV strains, transmissible gastroenteritis virus (TGEV and porcine respiratory CoV (PRCV, in complex with their receptor, porcine APN (pAPN, or with a neutralizing antibody. The data provide detailed information on the architecture of the dimeric pAPN ectodomain and its interaction with the CoV S. We show that a protruding receptor-binding edge in the S determines virus-binding specificity for recessed glycan-containing surfaces in the membrane-distal region of the pAPN ectodomain. Comparison of the RBDs of TGEV and PRCV to those of other related CoVs, suggests that the conformation of the S receptor-binding region determines cell entry receptor specificity. Moreover, the receptor-binding edge is a major antigenic determinant in the TGEV envelope S that is targeted by neutralizing antibodies. Our results provide a compelling view on CoV cell entry and immune neutralization, and may aid the design of antivirals or CoV vaccines. APN is also considered a target for cancer therapy and its structure, reported here, could facilitate the development of anti-cancer drugs.

  8. The combination of urinary IL - 6 and renal biometry as useful diagnostic tools to differentiate acute pyelonephritis from lower urinary tract infection.

    Science.gov (United States)

    Azab, Sherif; Zakaria, Mostafa; Raafat, Mona; Seief, Hadeel

    2016-01-01

    To evaluate the role of renal ultrasound (RUS) and urinary IL-6 in the differentiation between acute pyelonephritis (APN) and lower urinary tract infection (LUTI). This prospective study was carried out at the Pediatric and urology outpatient and inpatient departments of Cairo University Children's Hospital as well as October 6 University Hospital and it included 155 children between one month and fourteen years old with positive culture UTI. Patients were categorized into APN and LUTI based on their clinical features and laboratory parameters. Thirty healthy children, age and sex matched constituted the control group. Children with positive urine cultures were treated with appropriate antibiotics. Before treatment, urinary IL-6 was measured by enzyme immunoassay technique (ELISA), and renal ultrasound (RUS) was done. CRP (C-reactive protein), IL-6 and RUS were repeated on the 14th day of antibiotic treatment to evaluate the changes in their levels in response to treatment. UIL-6 levels were more significantly higher in patients with APN than in patients with LUTI (24.3±19.3pg/mL for APN vs. 7.3±2.7pg/mL in LUTI (95% CI: 2.6-27.4; p20pg/mL and serum CRP >20μg/mL were highly reliable markers of APN. Mean renal volume and mean volume difference between the two kidneys in the APN group were more than that of the LUTI and control groups (Purinary IL-6 levels have a highly dependable role in the differentiation between APN and LUTI especially in places where other investigations are not available and/ or affordable. Copyright© by the International Brazilian Journal of Urology.

  9. 20 Years of Developing Capacity for Action-Oriented Collaborative Regional Research in the Asia-Pacific Region

    Science.gov (United States)

    Tupas, L. M.; Stevenson, L. A.

    2015-12-01

    During its 3rd strategic phase, which ran from 2010 to 2015, the APN provided support for 123 projects through its competitive collaborative regional research and capacity development programmes. With over 250 peer-reviewed papers and the underlying philosophy that the regional research it undertakes engages at least two developing countries, the 3rd strategic phase is not only improving the research capabilities of nations in the region, but is engaging the developing country community in underpinning policy-relevant research. The extent to which science is contributing to policy is further evident in that 69% of the activities conducted had some form of science-policy mechanism built in to the project activities. The period of the 3rd Strategic Phase has been witness to significant changes in the make-up of the "conventional" global change arena, with the transition of some global change programmes into the new "Future Earth" initiative. At the same time, major events such as the Rio+20 Summit, the post-2015 Sustainable Development Goals, the establishment of an IPCC-related platform for biodiversity, i.e. IPBES, and the evolving engagement of science and policy communities has kept the APN busy at what it does best - networking and partnering with the international community. The APN has embraced these changes through its dynamism, allowing the APN to meet not only the needs of the scientists and decision makers its serves in the region but those of the international science communities as well. The challenge for the APN in its next two decades will be to ensure alignment with the transforming global change arena. With key phrases such as "policy-relevant science" and "science-policy interactions" being adopted broadly by the community at large these days, the APN's niche in the global community has received considerable recognition, particularly as other institutions strive to adopt similar practices that the APN has built over the last 20 years.

  10. Adiponectin enhances osteogenic differentiation in human adipose-derived stem cells by activating the APPL1-AMPK signaling pathway

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Tong; Wu, Yu-wei; Lu, Hui; Guo, Yuan [Second Dental Center, Peking University School and Hospital of Stomatology, Beijing (China); National Engineering Laboratory for Digital and Material Technology of Stomatology, Peking University School and Hospital of Stomatology, Beijing (China); Tang, Zhi-hui, E-mail: tang_zhihui@live.cn [Second Dental Center, Peking University School and Hospital of Stomatology, Beijing (China); National Engineering Laboratory for Digital and Material Technology of Stomatology, Peking University School and Hospital of Stomatology, Beijing (China)

    2015-05-29

    Human adipose-derived stem cells (hASCs) are multipotent progenitor cells with multi-lineage differentiation potential including osteogenesis and adipogenesis. While significant progress has been made in understanding the transcriptional control of hASC fate, little is known about how hASC differentiation is regulated by the autocrine loop. The most abundant adipocytokine secreted by adipocytes, adiponectin (APN) plays a pivotal role in glucose metabolism and energy homeostasis. Growing evidence suggests a positive association between APN and bone formation yet little is known regarding the direct effects of APN on hASC osteogenesis. Therefore, this study was designed to investigate the varied osteogenic effects and regulatory mechanisms of APN in the osteogenic commitment of hASCs. We found that APN enhanced the expression of osteoblast-related genes in hASCs, such as osteocalcin, alkaline phosphatase, and runt-related transcription factor-2 (Runx2, also known as CBFa1), in a dose- and time-dependent manner. This was further confirmed by the higher expression levels of alkaline phosphatase and increased formation of mineralization nodules, along with the absence of inhibition of cell proliferation. Importantly, APN at 1 μg/ml was the optimal concentration, resulting in maximum deposition of calcium nodules, and was significant superior to bone morphogenetic protein 2. Mechanistically, we found for the first time that APN increased nuclear translocation of the leucine zipper motif (APPL)-1 as well as AMP-activated protein kinase (AMPK) phosphorylation, which were reversed by pretreatment with APPL1 siRNA. Our results indicate that APN promotes the osteogenic differentiation of hASCs by activating APPL1-AMPK signaling, suggesting that manipulation of APN is a novel therapeutic target for controlling hASC fate. - Highlights: • Adiponectin enhances osteogenic differentiation in human adipose-derived stem cells. • The knock-down of APPL1 block the enhancement of

  11. Removal of Malachite Green from water using hydrothermally carbonized pine needles

    KAUST Repository

    Hammud, Hassan Hasan

    2015-01-01

    Hydrothermal carbonization of pine needles (HTC-PN) and their oxidized-activated form HTC-APN are prepared and applied for the adsorption of Malachite Green (MG) in aqueous solution. The HTC materials were characterized by thermal and TEM analysis. Adsorbent dose, initial concentration of MG, contact time, temperature and pH effect on MG adsorption onto the HTC materials were studied. The adsorption equilibrium data was best fitted by the Langmuir isotherm model and the adsorption kinetics followed pseudo-second-order models for both HTC-PN and HTC-APN. The maximum capacity predicted by the Langmuir nonlinear model is 52.91 and 97.08 mg g-1 for uptake of MG by HTC-PN and HTC-APN, respectively, at 30 °C. Thermodynamic investigations showed that the adsorption is spontaneous and endothermic in nature. Results suggest HTC-APN can be used as a low-cost adsorbent for MG removal from industrial wastewater. Yoon-Nelson is the best model with a column capacity of 38.3 mg g-1 for the adsorption of MG onto HTC-APN. This journal is

  12. Description and evaluation of an initiative to develop advanced practice nurses in mainland China.

    Science.gov (United States)

    Wong, Frances Kam Yuet; Peng, Gangyi; Kan, Eva C; Li, Yajie; Lau, Ada T; Zhang, Liying; Leung, Annie F; Liu, Xueqin; Leung, Vilna O; Chen, Weiju; Li, Ming

    2010-05-01

    This paper describes an initiative to develop Advanced Practice Nurses (APNs) in mainland China and evaluation of the outcomes of the described programme. The pioneer project was an APN postgraduate programme involving 38 students conducted in Guangzhou, China during 2004-2005. Data related to curriculum content and process, student performance, self-reported competence and programme effects were collected. Quantitative data such as demographic data, student performance were analysed using descriptive statistics and the pre and post self-reported practice of competence was compared using chi-square test. Qualitative data such as case reports and interviews were examined using thematic analyses. Reflective journals and case studies revealed the attributes of APNs in managing clinical cases at advanced level, applying theory into practice and exercising evidence-based practice. The relatively modest self-reported practice of competence suggested that the graduates were novice APNs and needed continued development after the completion of the programme. This study reports the experience of an initiative in China and suggests a useful curriculum framework for educating APNs. Copyright 2009 Elsevier Ltd. All rights reserved.

  13. Adiponectin improves coronary no-reflow injury by protecting the endothelium in rats with type 2 diabetes mellitus.

    Science.gov (United States)

    Han, Xue; Wu, Ye; Liu, Xin; Ma, Lu; Lv, Tingting; Sun, Qi; Xu, Wenli; Zhang, Suli; Wang, Ke; Wang, Wen; Ma, Xinliang; Liu, Huirong

    2017-08-31

    To determine the effect of adiponectin (APN) on the coronary no-reflow (NR) injury in rats with Type 2 diabetes mellitus (T2DM), 80 male Sprague-Dawley rats were fed with a high-sugar-high-fat diet to build a T2DM model. Rats received vehicle or APN in the last week and then were subjected to myocardial ischemia reperfusion (MI/R) injury. Endothelium-dependent vasorelaxation of the thoracic aorta was significantly decreased and serum levels of endothelin-1 (ET-1), intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were noticably increased in T2DM rats compared with rats without T2DM. Serum APN was positively correlated with the endothelium-dependent vasorelaxation, but negatively correlated with the serum level of ET-1. Treatment with APN improved T2DM-induced endothelium-dependent vasorelaxation, recovered cardiac function, and decreased both NR size and the levels of ET-1, ICAM-1 and VCAM-1. Hypoadiponectinemia was associated with the aggravation of coronary NR in T2DM rats. APN could alleviate coronary NR injury in T2DM rats by protecting the endothelium and improving microcirculation. © 2017 The Author(s).

  14. Knowledge Transfer and Dissemination of Advanced Practice Nursing Information and Research to Acute-Care Administrators.

    Science.gov (United States)

    Carter, Nancy; Dobbins, Maureen; Peachey, Gladys; Hoxby, Heather; Ireland, Sandra; Akhtar-Danesh, Noori; DiCenso, Alba

    2014-03-01

    The objective of this study was to ascertain the information needs and knowledge-dissemination preferences of acute-care administrators with respect to advanced practice nursing (APN). Supportive leadership is imperative for the success of APN roles and administrators need up-to-date research evidence and information, but it is unclear what the information needs of administrators are and how they prefer to receive the information. A survey tool was developed from the literature and from the findings of a qualitative study with acute-care leaders. Of 107 surveys distributed to nursing administrators in 2 teaching hospitals, 79 (73.8%) were returned. Just over half of respondents reported wanting APN information related to model of care and patient and systems outcomes of APN care; the majority expressed a preference for electronic transmission of the information. Researchers need multiple strategies for distributing context-specific APN evidence and information to nursing administrators. Copyright© by Ingram School of Nursing, McGill University.

  15. TNF-alpha, produced by feline infectious peritonitis virus (FIPV)-infected macrophages, upregulates expression of type II FIPV receptor feline aminopeptidase N in feline macrophages.

    Science.gov (United States)

    Takano, Tomomi; Hohdatsu, Tsutomu; Toda, Ayako; Tanabe, Maki; Koyama, Hiroyuki

    2007-07-20

    The pathogenicity of feline infectious peritonitis virus (FIPV) is known to depend on macrophage tropism, and this macrophage infection is enhanced by mediation via anti-S antibody (antibody-dependent enhancement, ADE). In this study, we found that TNF-alpha production was increased with viral replication in macrophages inoculated with a mixture of FIPV and anti-S antibody, and demonstrated that this culture supernatant had feline PBMC apoptosis-inducing activity. We also demonstrated that the expression level of the FIPV virus receptor, feline aminopeptidase N (fAPN), was increased in macrophages of FIP cats. For upregulation of TNF-alpha and fAPN in macrophages, viral replication in macrophages is necessary, and their expressions were increased by ADE of FIPV infection. It was demonstrated that a heat-resistant fAPN-inducing factor was present in the culture supernatant of FIPV-infected macrophages, and this factor was TNF-alpha: fAPN expression was upregulated in recombinant feline TNF-alpha-treated macrophages, and FIPV infectivity was increased in these macrophages. These findings suggested that FIPV replication in macrophages increases TNF-alpha production in macrophages, and the produced TNF-alpha acts and upregulates fAPN expression, increasing FIPV sensitivity.

  16. Gerontology found me: gaining understanding of advanced practice nurses in geriatrics.

    Science.gov (United States)

    Campbell-Detrixhe, Dia D; Grassley, Jane S; Zeigler, Vicki L

    2013-10-01

    Examining the meanings of the experiences of advanced practice nurses (APNs) who chose to work with older adults and why they continue to work with this population was the focus of this hermeneutic qualitative research study. Twelve geriatric APNs currently practicing in two South Central states were interviewed using an open-ended interview guide. Using Gadamerian hermeneutics, the researchers identified Gerontology Found Me as the significant expression that reflected the fundamental meaning of the experience as a whole. Four themes emerged that further described the meanings of the participants' personal, educational, and professional experiences: Becoming a Gerontology Nurse, Being a Gerontology Nurse, Belonging to Gerontology, and Bringing Others to Gerontology. This study concluded that APNs' personal and professional experiences were more influential than educational experiences to become geriatric nurses, and having these personal and professional experiences of being in relationship with older individuals further contributed to their choice of gerontology.

  17. Prognostic significance of aberrantly silenced ANPEP expression in prostate cancer

    DEFF Research Database (Denmark)

    Sørensen, Karina Dalsgaard; Abildgaard, Mette Opstrup; Haldrup, Christa

    2013-01-01

    Background:Novel biomarkers for prostate cancer (PC) are urgently needed. This study investigates the expression, epigenetic regulation, and prognostic potential of ANPEP in PC.Methods:Aminopeptidase N (APN; encoded by ANPEP) expression was analysed by immunohistochemistry using tissue microarrays...... in three hypermethylated prostate cell lines, suggesting epigenetic silencing. Negative APN immunoreactivity was significantly associated with short RFS and short CSS in the RP and CT cohort, respectively, independently of routine clinicopathological predictors. Combining APN with a known angiogenesis...... representing 267 radical prostatectomy (RP) and 111 conservatively treated (CT) PC patients. Clinical end points were recurrence-free survival (RFS) and cancer-specific survival (CSS), respectively. The ANPEP promoter methylation levels were determined by bisulphite sequencing or MethyLight analysis in 278...

  18. A latency analysis for M2M and OG-like traffic patterns in different HSPA core network configurations

    Directory of Open Access Journals (Sweden)

    M. V. Popović

    2014-11-01

    Full Text Available In this paper we present an analysis intended to reveal possible impacts of core network features on latency for modelled M2M and Online Gaming traffic. Simulations were performed in a live 3G/HSPA network. Test traffic simulating multiplayer real-time games and M2M applications was generated on 10 mobile phones in parallel, sending data to a remote server. APNs with different combinations of hardware and features (proxy server, different GGSNs and firewalls, usage of Service Awareness feature were chosen. The traffic was recorded on the Gn interface in the mobile core. The goal of experiments was to evaluate any eventually significant variation of average recorded RTTs in the core part of mobile network that would clearly indicate either the impact of used APN on delay for a specific traffic pattern, or selectivity of the APN towards different traffic patterns.

  19. Effect of Metformin-sustained Release Therapy on Low-density Lipoprotein Size and Adiponectin in the South Indian Women with Polycystic Ovary Syndrome.

    Science.gov (United States)

    Kumar, D Rama Nagendra; Seshadri, Krishna G; Pandurangi, Monna

    2017-01-01

    The aim of the study is to compare surrogate markers of cardiovascular disease (CVD) risk, such as adiponectin (APN) levels and low-density lipoprotein (LDL) size, before and after sustained release metformin (Met-SR) therapy in women with polycystic ovarian syndrome (PCOS). Sixty women with PCOS and sixty age-matched controls in the age group 18-45 years were recruited after obtaining informed consent. Women with PCOS were initiated on Met-SR 1 g orally, which was increased to 1.5 g after 2 weeks and continued up to 24 weeks. Demographic data along with family history of type 2 diabetes mellitus, PCOS, and CVD were collected. Lipid profile plasma APN levels and LDL size were measured before and after therapy in the PCOS group. Data analysis was performed using the GraphPad Prism-5 software. Women with PCOS had greater dyslipidemia, lower APN level and LDL size, and increased lipid accumulating product index as compared to controls. After 6 months of Met-SR therapy, women with PCOS demonstrated significant increase in plasma APN levels and LDL size and significant decrease in weight, waist-hip ratio (WHR), waist circumference (WC), and blood pressure (BP). A significant decrease was observed in body mass index (BMI) in the overweight and obese PCOS subgroups. Met-SR increases LDL size, APN concentration and decreases weight, WC, WHR, and BP in patients with PCOS. Met-SR may have salutary effects on LDL particle size through effects on APN levels in women with PCOS.

  20. Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus

    Directory of Open Access Journals (Sweden)

    Harbison Carole E

    2007-02-01

    Full Text Available Abstract Background Coronaviruses are an important cause of infectious diseases in humans, including severe acute respiratory syndrome (SARS, and have the continued potential for emergence from animal species. A major factor in the host range of a coronavirus is its receptor utilization on host cells. In many cases, coronavirus-receptor interactions are well understood. However, a notable exception is the receptor utilization by group 3 coronaviruses, including avian infectious bronchitis virus (IBV. Feline aminopeptidase N (fAPN serves as a functional receptor for most group 1 coronaviruses including feline infectious peritonitis virus (FIPV, canine coronavirus, transmissible gastroenteritis virus (TGEV, and human coronavirus 229E (HCoV-229E. A recent report has also suggested a role for fAPN during IBV entry (Miguel B, Pharr GT, Wang C: The role of feline aminopeptidase N as a receptor for infectious bronchitis virus. Brief review. Arch Virol 2002, 147:2047–2056. Results Here we show that, whereas both transient transfection and constitutive expression of fAPN on BHK-21 cells can rescue FIPV and TGEV infection in non-permissive BHK cells, fAPN expression does not rescue infection by the prototype IBV strain Mass41. To account for the previous suggestion that fAPN could serve as an IBV receptor, we show that feline cells can be infected with the prototype strain of IBV (Mass 41, but with low susceptibility compared to primary chick kidney cells. We also show that BHK-21 cells are slightly susceptible to certain IBV strains, including Ark99, Ark_DPI, CA99, and Iowa97 ( Conclusion We conclude that fAPN is not a functional receptor for IBV, the identity of which is currently under investigation.

  1. Evaluation of new American Academy of Pediatrics guideline for febrile urinary tract infection

    Science.gov (United States)

    Choi, Da Min; Heo, Tae Hoon; Yoo, Kee Hwan

    2015-01-01

    Purpose To evaluate the practical applications of the diagnosis algorithms recommended by the American Academy of Pediatrics urinary tract infection (UTI) guideline. Methods We retrospectively reviewed the medical records of febrile UTI patients aged between 2 and 24 months. The patients were divided into 3 groups: group I (patients with positive urine culture and urinalysis findings), group II (those with positive urine culture but negative urinalysis findings), and group III (those with negative urine culture but positive urinalysis findings). Clinical, laboratory, and imaging results were analyzed and compared between the groups. Results A total of 300 children were enrolled. The serum C-reactive protein level was lower in children in group II than in those in groups I and III (P<0.05). Children in group I showed a higher frequency of hydronephrosis than those in groups II and III (P<0.05). However, the frequencies of acute pyelonephritis (APN), vesicoureteral reflux (VUR), renal scar, and UTI recurrence were not different between the groups. In group I, recurrence of UTI and presence of APN were associated with the incidence of VUR (recurrence vs. no recurrence: 40% vs.11.4%; APN vs. no APN: 23.3% vs. 9.2%; P<0.05). The incidence of VUR and APN was not related to the presence of hydronephrosis. Conclusion UTI in febrile children cannot be ruled out solely on the basis of positive urinalysis or urine culture findings. Recurrence of UTI and presence of APN may be reasonable indicators of the presence of VUR. PMID:26512260

  2. Evaluation of a risk index for advanced proximal neoplasia of the colon.

    Science.gov (United States)

    Ruco, Arlinda; Stock, David; Hilsden, Robert J; McGregor, S Elizabeth; Paszat, Lawrence F; Saskin, Refik; Rabeneck, Linda

    2015-01-01

    A clinical risk index that uses distal colorectal findings at flexible sigmoidoscopy (FS) in conjunction with easily determined risk factors for advanced proximal neoplasia (APN) may be useful for tailoring or prioritizing screening with colonoscopy. To conduct an external evaluation of a previously published risk index in a large, well-characterized cohort. Cross-sectional. Teaching hospital and colorectal cancer screening center. A total of 5139 asymptomatic persons aged 50 to 74 (54.9% women) with a mean age (±SD) of 58.3 (±6.2) years. Between 2003 and 2011, all participants underwent a complete screening colonoscopy and removal of all polyps. Participants were classified as low, intermediate, or high risk for APN, based on their composite risk index scores. The concordance or c-statistic was used to measure discriminating ability of the risk index. A total of 167 persons (3.2%) had APN. The prevalence of those with APN among low-, intermediate-, and high-risk categories was 2.1%, 2.9%, and 6.5%, respectively. High-risk individuals were 3.2 times more likely to have APN compared with those in the low-risk category. The index did not discriminate well between those in the low- and intermediate-risk categories. The c-statistic for the overall index was 0.62 (95% confidence interval, 0.58-0.66). Distal colorectal findings were derived from colonoscopies and not FS itself. The risk index discriminated between those at low risk and those at high risk, but it had limited ability to discriminate between low- and intermediate-risk categories for prevalent APN. Information on other risk factors may be needed to tailor, or prioritize, access to screening colonoscopy. Copyright © 2015 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

  3. Positioning your business in the marketplace.

    Science.gov (United States)

    Lachman, V D

    1996-01-01

    Marketing the quality, cost-effective service delivered by advanced practice nurses (APNs) requires savvy in marketing principles. The basic principles of market segmentation: target (niche) marketing; and the four Ps of marketing mix--product, price, promotion, and place. The marketing process is presented along with examples. APNs' ability to successfully market their skills requires that they "position" themselves in the prospective buyer's mind. After a brief description of the customer's mind-set, the focus shifts specifically to promotion--marketing in action. Numerous no-cost/low-cost ideas are included.

  4. Department of the Navy Justification of Estimates for Fiscal Year 1985. Submitted to Congress February 1984. Procurement, Aircraft Procurement, Navy

    Science.gov (United States)

    1984-02-01

    j~r_ f i1~ -A’s OSI 14. 8 ProJect Finannial Plan (Cont’d): FY 1289 TOTAL Qty cost Qty Cost APN-5 223 $20,934 0&HN Install. (41) $4$54 2,605 APN-6...ATS) AMD Design Changes -W - 4-0 1_ _ OSI ? 11-84 Description/Justification (Cont’d): ALQ-126 Support Assembly Addition of Latching Relay to BRU-33 BRU...Activity 5 Modification Title and No.: Night Vision (OSIP 39-85) Modelo of Aircraft Affected: HII-IK Description/Justification: In order to improve tactical

  5. Self Assessment for the Safety of Research Reactor in Indonesia

    International Nuclear Information System (INIS)

    Melani, Ai; Chang, Soon Heung

    2008-01-01

    At the present Indonesia has no nuclear power plant in operation yet, although it is expected that the first nuclear power plant will be operated and commercially available in around the year of 2016 to 2017 in Muria Peninsula. National Nuclear Energy Agency (BATAN) has three research reactor; which are: Reactor Triga Mark II at Bandung, Reactor Kartini at Yogyakarta and Reactor Serbaguna (Multi Purpose Reactor) at Serpong. The Code of Conduct on the Safety of Research Reactors establishes 'best practice' guidelines for the licensing, construction and operation of research reactors. In this paper the author use the requirement in code of conduct to review the safety of research reactor in Indonesia

  6. PENYEBARAN INFORMASI MENGGUNAKAN WWW (WORLD WIDE WEB

    Directory of Open Access Journals (Sweden)

    Ika Atman Satya

    2011-12-01

    Full Text Available Media Informasi secara tradisional telah kita kenai dengan menggunakan koran, televisi, radio dan buku referensi. Media informasi tersebut untuk penyebarannya memerlukan penunjang agar informasi tersebut dapat disebarkan secara lutis. Selain penggunaan media tradisional tersebut penyebaran informasi dengan menggunakan jaringan komputer Internet juga berkembang. Salah satu cara penyebaran informasi dengan menggunakan aplikasi WWW (World Wide Web yang mempunyai kemampuan menggabungkan gambar, text dan suara secara interaktif. Pada tulisan ini akan dibahas tentang kemampuan, penggunaan dan pengembangan server WWW.

  7. PENGARUH JUS DAUN SIRIH (Piper betle Linn SEBAGAI BAHAN PRECURING DAN LAMA PENYIMPANAN TERHADAP KOMPOSISI KIMIA DAN ANGKA PEROKSIDA DENDENG AYAM PETELUR

    Directory of Open Access Journals (Sweden)

    Aloysia Tenny Damayanti Indriastuti

    2012-09-01

    mempertahankan komposisi kimia secara proposional dan menekan angka peroksida sehingga memperpanjang lama penyimpanan dendeng ayam petelur afkir. (Kata kunci: Daging ayam, Daun sirih, Dendeng, Komposisi kimia, Angka peroksida

  8. KONSEP RUANG TERBUKA PUBLIK MAHASISWA SEBAGAI PENGHUBUNG ANTAR UNIT DI UNIVERSITAS TANJUNGPURA

    Directory of Open Access Journals (Sweden)

    Yudi Purnomo

    2014-01-01

    Zahnd, Markus. 2009.  Pendekatan dalam Perancangan Arsitektur: Metode untuk Menganalisis dan Merancang Arsitektur secara Efektif.Penerbit Kanisius, Semarang: Soegijapranata University Press, Yogyakarta

  9. Detection of parenchymal abnormalities in experimentally induced acute pyelonephritis in rabbits using contrast-enhanced ultrasonography, CT, and MRI

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Jeong Ah; Kim, Bo Hyun; Kim, Seung Kwon; Seo, Jin Won [Dept. of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Kim, Jong Sung [Laboratory Animal Research Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2016-12-15

    We evaluated the efficacy of contrast-enhanced ultrasonography (CEUS) in detecting acute pyelonephritis (APN) using the rabbit kidney model and compared it with CT and MRI. This study was approved by the Institutional Review Board. In a total of 20 New Zealand White rabbits, APN was induced experimentally. CEUS, CT, and MRI were performed on the first, third, and seventh postoperative days. After imaging studies, the subjects were sacrificed and the pathological diagnosis of APN was confirmed in each animal by a pathologist. Imaging studies were obtained in eight animals, including eight CEUS, four computed tomography (CT), and four magnetic resonance imaging (MRI) images. CEUS depicted diffuse renal enlargement (7), diffuse heterogeneous parenchymal enhancement (6), and focal areas of decreased parenchymal enhancement (6). These findings were well correlated with the CT and MRI findings in five cases in which these studies were available. CT and MRI showed diffuse renal enlargement, diffuse heterogeneous parenchymal enhancement, focal areas of decreased parenchymal enhancement, focal contour bulging, and the finding of perinephric spread of infection. In a rabbit model, CEUS could depict the parenchymal lesions of APN similar to CT or MRI; however, it was limited in depicting the perinephric extension of inflammation.

  10. Intimate partner violence: advanced practice nurses clinical stories of success and challenge.

    Science.gov (United States)

    Brykczynski, Karen A; Crane, Patricia; Medina, Cindy K; Pedraza, Dora

    2011-03-01

    This qualitative study presents knowledge from clinical experiences of advanced practice nurses (APNs) working with women who have experienced intimate partner violence (IPV). Face-to-face interviews were conducted with ten APNs to discover their ways of being with, supporting, and helping women who have experienced IPV. Interviews were transcribed and analyzed using interpretive phenomenology. Analysis proceeded from whole to parts and back to whole with ongoing attention to maintaining the situational context to guide interpretation of meanings. APNs experience both challenges and successes in caring for women who live with IPV. Findings consist of interpretations of clinical stories to uncover knowledge embedded in practice. Healing practices and ways of being survival facilitators for women and children are identified and described. APNs are in a unique position to help families who live with abuse, but may lack resources and knowledge about the most effective interventions. They may become cynical and frustrated with feelings of futility when faced with the repeating patterns associated with the cycle of violence. The goals of this study are to promote more comprehensive understanding of IPV and stimulate changes in education, practice, research, and health policy. ©2011 The Author(s) Journal compilation © 2011 American Academy of Nurse Practitioners.

  11. Estimating long-term volatility parameters for market-consistent models

    African Journals Online (AJOL)

    Contemporary actuarial and accounting practices (APN 110 in the South African context) require the use of market-consistent models for the valuation of embedded investment derivatives. These models have to be calibrated with accurate and up-to-date market data. Arguably, the most important variable in the valuation of ...

  12. Observations of atmosphere-biosphere exchange of total and speciated peroxynitrates: nitrogen fluxes and biogenic sources of peroxynitrates

    Directory of Open Access Journals (Sweden)

    K.-E. Min

    2012-10-01

    Full Text Available Peroxynitrates are responsible for global scale transport of reactive nitrogen. Recent laboratory observations suggest that they may also play an important role in delivery of nutrients to plant canopies. We measured eddy covariance fluxes of total peroxynitrates (ΣPNs and three individual peroxynitrates (APNs ≡ PAN + PPN + MPAN over a ponderosa pine forest during the Biosphere Effects on AeRosols and Photochemistry EXperiment 2009 (BEARPEX 2009. Concentrations of these species were also measured at multiple heights above and within the canopy. While the above-canopy daytime concentrations are nearly identical for ΣPNs and APNs, we observed the downward flux of ΣPNs to be 30–60% slower than the flux of APNs. The vertical concentration gradients of ΣPNs and APNs vary with time of day and exhibit different temperature dependencies. These differences can be explained by the production of peroxynitrates other than PAN, PPN, and MPAN within the canopy (presumably as a consequence of biogenic VOC emissions and upward fluxes of these PN species. The impact of this implied peroxynitrate flux on the interpretation of NOx fluxes and ecosystem N exchange is discussed.

  13. 76 FR 2710 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

    Science.gov (United States)

    2011-01-14

    ..., APN and ICONMA, Winston-Salem, North Carolina. The notice was published in the Federal Register on... Seaton Corporation. The notices were published on the Federal Register on April 19, 2010 (75 FR 20385... workers are engaged in employment related to the production of desktop computers. New information shows...

  14. Advanced practice nursing for enduring health needs management: a global perspective.

    Science.gov (United States)

    Koskinen, Liisa; Mikkonen, Irma; Graham, Iain; Norman, Linda D; Richardson, Jim; Savage, Eileen; Schorn, Mavis

    2012-07-01

    Advanced practice nursing expertise has been acknowledged worldwide as one response to the challenges arising from changes in society and health care. The roots of advanced practice nursing education are at the University of Colorado where the first known programme started in 1965. In many countries advanced practice nurses (APNs) have taken responsibility for routine patient care formerly carried out by physicians in order to reduce their workload. However, more and more, APNs have taken responsibility for new service areas and quality programmes not previously provided. Chronic disease management is one of these new service areas because long-term diseases are increasingly challenging service systems globally. This article is based on an international APN partnership. The aim of the article is to describe how the partnership will design a 15 ECTS credit course on Enduring Health Need Management as a cross-cultural collaborative endeavour. The adaptation of an inquiry based learning framework will be described drawing on four main principles of the theory: authentic learning communities; student encouragement in analysing gradually more complicated problems; networking in knowledge creation and; student engagement and activity. The cross-cultural online course aims to increase APNs' intercultural competence as well as their global and international work orientation. Copyright © 2011 Elsevier Ltd. All rights reserved.

  15. Structure-Guided, Single-Point Modifications in the Phosphinic Dipeptide Structure Yield Highly Potent and Selective Inhibitors of Neutral Aminopeptidases

    Energy Technology Data Exchange (ETDEWEB)

    Vassiliou, Stamatia; Węglarz-Tomczak, Ewelina; Berlicki, Łukasz; Pawełczak, Małgorzata; Nocek, Bogusław; Mulligan, Rory; Joachimiak, Andrzej; Mucha, Artur

    2014-10-09

    Seven crystal structures of alanyl aminopeptidase from Neisseria meningitides (the etiological agent of meningitis, NmAPN) complexed with organophosphorus compounds were resolved to determine the optimal inhibitor-enzyme interactions. The enantiomeric phosphonic acid analogs of Leu and hPhe, which correspond to the P1 amino acid residues of well-processed substrates, were used to assess the impact of the absolute configuration and the stereospecific hydrogen bond network formed between the aminophosphonate polar head and the active site residues on the binding affinity. For the hPhe analog, an imperfect stereochemical complementarity could be overcome by incorporating an appropriate P1 side chain. The constitution of P1'-extended structures was rationally designed and the lead, phosphinic dipeptide hPhePψ[CH2]Phe, was modified in a single position. Introducing a heteroatom/heteroatom-based fragment to either the P1 or P1' residue required new synthetic pathways. The compounds in the refined structure were low nanomolar and subnanomolar inhibitors of N. meningitides, porcine and human APNs, and the reference leucine aminopeptidase (LAP). The unnatural phosphinic dipeptide analogs exhibited a high affinity for monozinc APNs associated with a reasonable selectivity versus dizinc LAP. Another set of crystal structures containing the NmAPN dipeptide ligand were used to verify and to confirm the predicted binding modes; furthermore, novel contacts, which were promising for inhibitor development, were identified, including a π-π stacking interaction between a pyridine ring and Tyr372.

  16. Removal of Malachite Green from water using hydrothermally carbonized pine needles

    KAUST Repository

    Hammud, Hassan Hasan; Shmait, Abeer; Hourani, Nadim

    2015-01-01

    Hydrothermal carbonization of pine needles (HTC-PN) and their oxidized-activated form HTC-APN are prepared and applied for the adsorption of Malachite Green (MG) in aqueous solution. The HTC materials were characterized by thermal and TEM analysis

  17. Efficacy of parenteral administration of bee venom in experimental arthritis in the rat: a comparison with methotrexate.

    Science.gov (United States)

    Yamasaki, Simone C; Mendes, Mariana T; Alponti, Rafaela F; Silveira, Paulo F

    2015-05-01

    The use of bee venom (BV) to treat inflammation and pain in arthritis has become increasingly common. This study aimed to compare the effects of BV and methotrexate (MTX), the most used disease-modifying anti-rheumatic drug, in arthritic rats. Edema, erythema, cyanosis, hyperalgesia, reduction of the body mass gain, high circulating tumor necrosis factor alpha (TNF-α) and anti-type II collagen antibodies (AACII), and altered activity of basic (APB) and neutral (APN) aminopeptidases and dipeptidyl peptidase IV (DPPIV) are present in arthritic rats. MTX and/or BV do not affect AACII in healthy or arthritic individuals, but restores TNF-α to normal levels in arthritic rats. BV restores body mass gain to normal levels and MTX ameliorates body mass gain. BV contains DPPIV. BV restores APN in synovial fluid (SF) and in soluble fraction (S) from synovial tissue (ST), and DPPIV in solubilized membrane-bound fraction (M) from peripheral blood mononuclear cells (PBMCs). MTX restores APN of SF, as well as ameliorates APB of S-PBMCs, APN of S-ST and DPPIV of M-PBMCs. The combination therapy does not overcome the effects of BV or MTX alone on the peptidase activities. Edema is ameliorated by MTX or BV alone. MTX, but not BV, is effective in reducing hyperalgesia. Data show that anti-arthritic effects of BV at non-acupoints are not negligible when compared with MTX. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Bacillus thuringiensis Cry1Ca-resistant Spodoptera exigua lacks expression of one of four Aminopeptidase N genes

    NARCIS (Netherlands)

    Herrero, S.; Gechev, T.; Bakker, P.L.; Moar, W.; Maagd, de R.A.

    2005-01-01

    BACKGROUND: Insecticidal toxins from Bacillus thuringiensis bind to receptors on midgut epithelial cells of susceptible insect larvae. Aminopeptidases N (APNs) from several insect species have been shown to be putative receptors for these toxins. Here we report the cloning and expression analysis of

  19. Exploration of priority actions for strengthening the role of nurses in achieving universal health coverage

    Directory of Open Access Journals (Sweden)

    Rowaida Al Maaitah

    Full Text Available ABSTRACT Objective: to explore priority actions for strengthening the role of Advanced Practice Nurses (APNs towards the achievement of Universal Health Converge (UHC as perceived by health key informants in Jordan. Methods: an exploratory qualitative design, using a semi-structured survey, was utilized. A purposive sample of seventeen key informants from various nursing and health care sectors was recruited for the purpose of the study. Content analysis utilizing the five-stage framework approach was used for data analysis. Results: the findings revealed that policy and regulation, nursing education, research, and workforce were identified as the main elements that influence the role of APNs in contributing to the achievement of UHC. Priority actions were identified by the participants for the main four elements. Conclusion: study findings confirm the need to strengthen the role of APNs to achieve UHC through a major transformation in nursing education, practice, research, leadership, and regulatory system. Nurses should unite to come up with solid nursing competencies related to APNs, PHC, UHC, leadership and policy making to strengthen their position as main actors in influencing the health care system and evidence creation.

  20. CPAP Tips

    Medline Plus

    Full Text Available ... 47 Santé - L’apnée du sommeil : de nouvelles solutions - Duration: 5:48. Télé Matin 209 views New ... 3:31 Loading more suggestions... Show more Language: English Location: United States Restricted Mode: Off History Help ...

  1. Focused development of advanced practice nurse roles for specific patient groups in a Swiss university hospital

    Science.gov (United States)

    Spichiger, Elisabeth; Zumstein-Shaha, Maya; Schubert, Maria; Herrmann, Luzia

    2018-02-01

    Background: To cover future health care needs of the population, new care models are necessary. The development of advanced nursing practice (ANP) offers the opportunity to meet these challenges with novel services. At the Inselspital, Bern University Hospital, ANP services and corresponding advanced practice nurse (APN) roles have been developed since 2011. Purpose: The aim is to develop innovative and evidence based ANP services to supplement health care for specific patient groups and their family members with the goal to improve safety and achieve better outcomes. Methods: Project-based ANP services are developed in close collaboration of clinical departments and the Nursing Development Unit (NDU) of the Directorate of Nursing. Structure, process and outcome data are collected for evaluation. Findings: Currently, five ANP services are established and running, eight more are in the developmental phase. Most services address the long term care of patients with chronic illnesses and their family members. Ten APNs work between 10 % and 80 %, three are leading an ANP-team. APNs work over 50 % in direct clinical practice, primarily in counselling. An ANP network connects APNs and NDU, promoting synergy and exchange. Conclusions: The available resources often constitute a challenge for the development of ANP services. Vital for the long-term success are an adequate extent of the position, the support by department directorate, the conceptual framework that is implemented across the whole hospital, and the development within project structures.

  2. Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells.

    Science.gov (United States)

    Han, Sora; Jeong, Ae Lee; Lee, Sunyi; Park, Jeong Su; Kim, Kwang Dong; Choi, Inpyo; Yoon, Suk Ran; Lee, Myung Sok; Lim, Jong-Seok; Han, Seung Hyun; Yoon, Do Young; Yang, Young

    2013-05-01

    Previously, we found that adiponectin (APN) suppresses IL-2-induced NK cell activation by downregulating the expression of the IFN-γ-inducible TNF-related apoptosis-inducing ligand and Fas ligand. Although the antitumor function of APN has been reported in several types of solid tumors, with few controversial results, no lymphoma studies have been conducted. In this study, we assessed the role of APN in immune cell function, including NK cells, CTLs, and myeloid-derived suppressor cells, in EL4 and B16F10 tumor-bearing APN knockout (KO) mice. We observed attenuated EL4 growth in the APNKO mice. Increased numbers of splenic NK cells and splenic CTLs were identified under naive conditions and EL4-challenged conditions, respectively. In APNKO mice, splenic NK cells showed enhanced cytotoxicity with and without IL-2 stimulation. Additionally, there were decreased levels of myeloid-derived suppressor cell accumulation in the EL4-bearing APNKO mice. Enforced MHC class I expression on B16F10 cells led to attenuated growth of these tumors in APNKO mice. Thus, our results suggest that EL4 regression in APNKO mice is not only due to an enhanced antitumor immune response but also to a high level of MHC class I expression.

  3. PERANCANGAN PENGEMBANGAN DIGITAL LIBRARY BERBASIS WEB RESPONSIVE

    Directory of Open Access Journals (Sweden)

    Tri Listyorini

    2015-04-01

    Full Text Available ABSTRAK E-book merupakan cara praktis untuk membaca sebuah buku. E-book bisa kita akses melalui laptop, komputer, maupun smartphone. Dalam penelitian kali ini Digital Library mengambil studi kasus pada Fakultas teknik merupakan salah satu fakultas yang ada di Universitas Muria Kudus yang ingin menjembatani dosen dan mahasiswa agar tidak bingung untuk mencari referensi buku yang dicari. Oleh karena itu Digital Library sangat dibutuhkan. Konsep Digital Library yang akan dibuat ini adalah berisi E-book dari bidang ilmu dari fakultas teknik. Dan agar dapat diakses menggunakan bermacam-macam gadget, maka Digital Library ini akan dikembangkan dengan konsep web Responsif. Dengan metode web Responsif ini tampilan dari Digital Library dapat menyesuaikan gadget yang digunakan dan mudah di akses oleh semua kalangan khususnya di fakultas teknik Universitas Muria Kudus. Hasil yang diharapkan dalam penelitian ini adalah sebuah Digital Library berbasis web Responsif, yang dapat digunakan untuk memberikan kemudahan dalam memperoleh E-book, jurnal dan sebagainya. Kata kunci: E-book, web responsif, digital library.

  4. The Influence of atmospheric conditions to probabilistic calculation of impact of radiology accident on PWR 1000 MWe

    International Nuclear Information System (INIS)

    Pande Made Udiyani; Sri Kuntjoro

    2015-01-01

    The calculation of the radiological impact of the fission products releases due to potential accidents that may occur in the PWR (Pressurized Water Reactor) is required in a probabilistic. The atmospheric conditions greatly contribute to the dispersion of radionuclides in the environment, so that in this study will be analyzed the influence of atmospheric conditions on probabilistic calculation of the reactor accidents consequences. The objective of this study is to conduct an analysis of the influence of atmospheric conditions based on meteorological input data models on the radiological consequences of PWR 1000 MWe accidents. Simulations using PC-Cosyma code with probabilistic calculations mode, the meteorological data input executed cyclic and stratified, the meteorological input data are executed in the cyclic and stratified, and simulated in Muria Peninsula and Serang Coastal. Meteorological data were taken every hour for the duration of the year. The result showed that the cumulative frequency for the same input models for Serang coastal is higher than the Muria Peninsula. For the same site, cumulative frequency on cyclic input models is higher than stratified models. The cyclic models provide flexibility in determining the level of accuracy of calculations and do not require reference data compared to stratified models. The use of cyclic and stratified models involving large amounts of data and calculation repetition will improve the accuracy of statistical calculation values. (author)

  5. Results of a five-year study of 99mTc DMSA renal scintigraphy in children and adolescents following acute pyelonephritis

    International Nuclear Information System (INIS)

    Chroustova, D.; Palyzova, D.; Kolska, M.; Urbanova, I.

    2006-01-01

    Renal scintigraphy, generally using 99' mTc-DMSA, is the accepted reference standard for detection of renal cortical changes. The timing of the test, i.e., whether an acute 99m Tc-DMSA scan, a follow-up only or both scans should be performed, however, remains open to discussion. In our study, a six-month follow- up DMSA scan was performed in all the children diagnosed with a first attack of acute pyelonephritis (APN) in two large paediatric clinics of Charles University's 3 rd School of Medicine in Prague during a five-year period. All diagnoses were confirmed by a paediatric nephrologist. 382 children (267 girls, 115 boys) aged between 7 months and 19 years were included in the study. For analytical purposes, the patients were divided into 4 age groups: I - less than 1 year of age, II - 1-5 years, III - 5-10 years, and IV - 10-19 years. In all children younger than five years, a micturition cystourethrogram (MCUG) for detection of vesicoureteric reflux (VUR) was performed between one and three months after the APN episode. Static renal scintigraphy, using an HR collimator with parallel holes was performed using a planar Gamma camera MB 9200 (Gamma Budapest) in all children six months after APN, with a complement of pinhole images, SPECT or PSPECT of the kidneys. 1. In group I, all four children with positive VUR on MCUG had a pathological DMSA scan, while only two of the 32 patients with negative VUR had a pathological DMSA. 2. In group II, 17 children had VUR on MCUG, six of them with a pathological and 11 with a normal DMSA scan. Most of the 221 children without VUR had a normal DMSA scintigraphy; pathological findings were present in 17 children only. 3. In group III, all children with VUR, but only 5 out of 53 without VUR, had a pathological DMSA scan. 4. Five out of 50 children in group IV had a pathological DMSA. APN occurred most frequently in group II (62.3%, or 238 children) and ranged between 10-15% in the remaining groups. APN was found very frequently

  6. Diagnostic role of initial renal cortical scintigraphy in children with the first episode of acute pyelonephritis

    International Nuclear Information System (INIS)

    Jaksic, E.; Bogdanovic, R.; Artiko, V.

    2011-01-01

    Assessment of the first febrile urinary tract infection (UTI) in children has been the subject of debate for many years. Diagnosis of acute pyelonephritis (APN) is usually based on clinical and biological data. The clinical usefulness of early Tc-99m dimercaptosuccinic acid (DMSA) scintigraphy remains controversial, although it may influence the type and duration of treatment. The aim of this study was to assess the role of initial cortical scintigraphy in the detection of early renal parenchymal damage in children highly suspected of having APN and to compare the scintigraphic findings with selected clinical/laboratory parameters and ultrasonography. A prospective study was conducted in 34 infants and young children (18 boys, 16 girls), aged 1.5-36 months (mean 9.8±8.7 months), hospitalized with a first episode of clinically suspected APN. Within the first 5 days after admission, Tc-99m DMSA renal scintigraphy, ultrasonography (US), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), white blood cell count (WBC) and urine analyses were performed. DMSA scintigraphy showed changes consistent with APN in 27/34 (79%) patients, with a mean age of 10.9 months, including 12 males (44%) and 15 (56%) females. Out of 9 febrile children with negative urine culture and supportive evidence of UTI, scintigraphy showed parenchymal involvement in 8 children (24% in the whole group, 30% in scintigraphically documented APN). There were no statistically significant correlations between the frequency or size of the initial scintigraphic abnormalities and age, sex, body temperature, CRP levels or ESR. A CRP level of >54 mg/L and a WBC of >13,300/mm 3 had sensitivities of 56 and 59% and specificities of 86 and 71%, respectively. US showed changes consistent with APN in 7/34 (21%) in the whole group and in 7/27 (26%) patients with positive cortical scan (p<0.05). Initial DMSA renal scintigraphy is a sensitive method for the early diagnosis of APN in young children and is

  7. The valuation of 99Tcm-DMSA renal cortical scintigraphy for prediction of renal scarring in children with acute pyelonephritis

    International Nuclear Information System (INIS)

    Zhao Ruifang; Ji Zhiying; Lv Xiaomei; Wu Ha; Li Yiwei; Gu Fanlei; Zhao Xiaofei

    2009-01-01

    Objective: Acute pyelonephritis (APN) is a common infectious disease in childhood. APN may result in ineversible renal scarring. 99 Tc m -dimercaptsuccinic (DMSA) renal cortical scintigraphy was reported to be highly sensitive and specific for detection APN and renal scarring. The aim of this study was to determine the incidence of renal scarring in a group of children with APN and to evaluate the relative factors at risk of scarring using 99 Tc m -DMSA renal cortical scintigraphy. Methods: One hundred and eighteen patients (44 males, 74 females, age range: 1 month to 14 years) with APN underwent DMSA renal cortical scan before treatment and six month after treatment to identify renal damage and renal scarring. The degree of renal damage was divided to grade I to IV. A directed radionuclide cystography (DRC) was performed in 72 cases to evaluate vesicoureteric reflux (VUR). Statistical analysis between all those relative factors was performed using Spearman grading relational analysis. The software was SPSS 11.5. Results: The follow-up renal cortical scan revealed that 79 normal kidneys on first scan remained normal; of 64 kidneys with grade I damage, 7.81% (5/64) developed renal scar; of 51 kidneys with grade II, 49.02% (25/51) developed renal scar; of 19 with grade III, 68.42% (13/19) developed renal scar; of 23 with grade IV, 100.00% (23/23) developed renal scar. There was a significant relationship between the incidence of renal scar on follow-up and the grade of renal damage on first scan (r=0.877, P<0.01). VUR was found in 54.17% (78/144) per renal unit. Only 4.55% (3/66) of those with non-refluxing ureters developed renal scars on follow-up. One of four patients with mild-refluxing ureters developed renal scars. 46.51% (20/43) of those with moderate-refluxing ureters developed renal scars. 87.10% (27/31) of those with severe-refluxing ureters developed renal scars. There was a significant relationship between the incidence of renal scarring in follow-up and

  8. Communication latencies of Apple push notification messages relevant for delivery of time-critical information to anesthesia providers.

    Science.gov (United States)

    Rothman, Brian S; Dexter, Franklin; Epstein, Richard H

    2013-08-01

    Tablet computers and smart phones have gained popularity in anesthesia departments for educational and patient care purposes. VigiVU(™) is an iOS application developed at Vanderbilt University for remote viewing of perioperative information, including text message notifications delivered via the Apple Push Notification (APN) service. In this study, we assessed the reliability of the APN service. Custom software was written to send a message every minute to iOS devices (iPad(®), iPod Touch(®), and iPhone(®)) via wireless local area network (WLAN) and cellular pathways 24 hours a day over a 4-month period. Transmission and receipt times were recorded and batched by days, with latencies calculated as their differences. The mean, SEM, and the exact 95% upper confidence limits for the percent of days with ≥1 prolonged (>100 seconds) latency were calculated. Acceptable performance was defined as mean latency 100 seconds. Testing conditions included fixed locations of devices in high signal strength locations. Mean latencies were 173,000 iPad and iPod latencies, none were >100 seconds. For iPhone latencies, 0.03% ± 0.01% were >100 seconds. The 95% upper confidence limits of days with ≥1 prolonged latency were 42% (iPhone) and 5% to 8% (iPad, iPod). The APN service was reliable for all studied devices over WLAN and cellular pathways, and performance was better than third party paging systems using Internet connections previously investigated using the same criteria. However, since our study was a best-case assessment, testing is required at individual sites considering use of this technology for critical messaging. Furthermore, since the APN service may fail due to Internet or service provider disruptions, a backup paging system is recommended if the APN service were to be used for critical messaging.

  9. Effector/memory CD8+ T cells synergize with co-stimulation competent macrophages to trigger autoimmune peripheral neuropathy.

    Science.gov (United States)

    Yang, Mu; Shi, Xiang Qun; Peyret, Corentin; Oladiran, Oladayo; Wu, Sonia; Chambon, Julien; Fournier, Sylvie; Zhang, Ji

    2018-04-05

    Autoimmune peripheral neuropathy (APN) such as Guillain Barre Syndrome (GBS) is a debilitating illness and sometimes life threatening. The molecular and cellular mechanisms remain elusive but exposure to environmental factors including viral/bacterial infection and injury is highly associated with disease incidence. We demonstrated previously that both male and female B7.2 (CD86) transgenic L31 and L31/CD4KO mice develop spontaneous APN. Here we further reveal that CD8 + T cells in these mice exhibit an effector/memory phenotype, which bears a resemblance to the CD8 + T cell response following persistent cytomegalovirus (CMV) infection in humans and mice, whilst CMV has been considered as one of the most relevant pathogens in APN development. These activated, peripheral myelin Ag specific CD8 + T cells are required for the disease initiation. While an injury to a peripheral nerve results in Wallerian degeneration in control littermates, the same injury accelerates the development of APN in other non-injured nerves of L31 mice which have a predisposed inflammatory background consisting of effector/memory CD8 + T (CD8 + T EM ) cells. However, CD8 + T EM cells alone are not sufficient. A certain threshold of B7.2 expression on nerve macrophages is an additional requisite. Our findings reveal that indeed, the synergism between CD8 + T EM cells and co-stimulation competent macrophages is crucial in inducing autoimmune-mediated peripheral neuropathy. The identification of decisive molecular/cellular players connecting environmental triggers and the occurrence of APN provides opportunities to prevent disease onset, reduce relapses and develop new therapeutic strategies. Crown Copyright © 2018. Published by Elsevier Inc. All rights reserved.

  10. Evaluation of intestinal phosphate binding to improve the safety profile of oral sodium phosphate bowel cleansing.

    Directory of Open Access Journals (Sweden)

    Stef Robijn

    Full Text Available Prior to colonoscopy, bowel cleansing is performed for which frequently oral sodium phosphate (OSP is used. OSP results in significant hyperphosphatemia and cases of acute kidney injury (AKI referred to as acute phosphate nephropathy (APN; characterized by nephrocalcinosis are reported after OSP use, which led to a US-FDA warning. To improve the safety profile of OSP, it was evaluated whether the side-effects of OSP could be prevented with intestinal phosphate binders. Hereto a Wistar rat model of APN was developed. OSP administration (2 times 1.2 g phosphate by gavage with a 12h time interval induced bowel cleansing (severe diarrhea and significant hyperphosphatemia (21.79 ± 5.07 mg/dl 6h after the second OSP dose versus 8.44 ± 0.97 mg/dl at baseline. Concomitantly, serum PTH levels increased fivefold and FGF-23 levels showed a threefold increase, while serum calcium levels significantly decreased from 11.29 ± 0.53 mg/dl at baseline to 8.68 ± 0.79 mg/dl after OSP. OSP administration induced weaker NaPi-2a staining along the apical proximal tubular membrane. APN was induced: serum creatinine increased (1.5 times baseline and nephrocalcinosis developed (increased renal calcium and phosphate content and calcium phosphate deposits on Von Kossa stained kidney sections. Intestinal phosphate binding (lanthanum carbonate or aluminum hydroxide was not able to attenuate the OSP induced side-effects. In conclusion, a clinically relevant rat model of APN was developed. Animals showed increased serum phosphate levels similar to those reported in humans and developed APN. No evidence was found for an improved safety profile of OSP by using intestinal phosphate binders.

  11. Perancangan Radio Streaming Edukasi (Studi Kasus Balai Pengembangan Media Radio YOGYAKARTA)

    OpenAIRE

    Nurwulan, Ayu Isni; Paputungan, Irving Vitra

    2009-01-01

    Pendidikan berkualitas sudah sewajarnya bisa dinikmati secara merata oleh semua orang. Mediapembelajaran secara audio yang selama ini disampaikan masih memiliki banyak keterbatasan, terutama padalingkup wilayah penyampaian. Dalam makalah ini, sebuah media pendidikan berbasis audio dengan cara laindiusulkan. Media tersebut bernama radio streaming. Pembuatan radio streaming memerlukan banyak analisissehingga perancangannya tepat. Hasil analisis dan perancangan yang disampaikan dalam makalah ini...

  12. PENGEMBANGAN KOMPETENSI PROFESIONAL BERKELANJUTAN DOSEN VOKASI PADA PENDIDIKAN VOKASIONAL DI LAMPUNG

    OpenAIRE

    S. Sugiyanto; S. Slamet; S. Sugiyono

    2016-01-01

    Tujuan penelitian ini adalah menghasilkan model pengembangan kompetensi profesional berkelanjutan bagi setiap dosen vokasi (PKPB-DV) agar memiliki kompetensi untuk dapat menjalankan tugas pokok dan fungsinya.  Metode penelitian dan pengembangan digunakan untuk menjawab pertanyaan penelitian, dengan subjek penelitian pegawai, pimpinan perguruan tinggi, dosen yang ditentukan secara purposif. Data dikumpulkan dengan pedoman wawancara dan angket serta dianalisis secara deskripsi kualitatif. Hasil...

  13. BISA ULAR MENINGKATKAN DAYA FAGOSITOSIS MAKROFAG PERITONEUM MENCIT TERHADAP KUMAN STREPTOKOKUS GRUP B SNAKE VENOM ENHANCES THE PHAGOCYTIC CAPABILITY OF PERITONEAL MACROPHAGES OF MICE AGAINST THE GROUP B STREPTOCOCCUS

    Directory of Open Access Journals (Sweden)

    Chandramaya Siska Damayanti

    2007-06-01

    Full Text Available Penelitian ini bertujuan mengetahui efek pemberian bisa ular tanah (Calloselasma rhodostoma, ular kobra (Naja naja sputatrix, dan ular welang Bungarus fasciatus pada daya fagositosis makrofag peritoneal mencit terhadap kuman streptokokus grup B. Mencit diberi berbagai dosis bisa ular secara peroral selama 7 hari atau secara intravena sebanyak 3 kali dengan selang waktu penyuntikan 3 hari sekali. Di akhir percobaan

  14. Keabsahan Dan Kekuatan Hukum Layanan Multi Level Marketing Di Kota Manado

    OpenAIRE

    Mandang, Christian Leonardo

    2016-01-01

    Tujuan dilakukannya penelitian ini adalah untuk mengetahui apa landasan hukum yang mendasari keabsahan layanan Multi Level Marketing dan bagaimana sebuah Perusahaan dapat memenuhi syarat untuk menjalankan sistem Multi Level Marketing. Dengan menggunakan metode penelitian yuridis normatif, maka dapat disimpulkan: 1. Kehadiran Perusahaan dan kegiatan USAha Multi Level Marketing baik secara global maupun secara nasional, khususnya kehadirannya di negara Indonesia berperan untuk membantu berbagai...

  15. MONITORING TETESAN INFUS BERBASIS MIKROKONTROLER ATMEGA16

    Directory of Open Access Journals (Sweden)

    Ardiyanto Iqbal Nugroho

    2015-09-01

    Penelitian ini menghasilkan suatu alat monitoring tetesan infus yang dapat memberikan informasi mengenai laju kecepatan tetesan dan kondisi cairan pada infus. Sistem yang secara realtime dimonitoring oleh perawat ini dapat mengurangi permasalahan yang timbul karena kelalaian petugas. Sehingga perawat tidak secara manual dalam mengatur kecepatan tetesan infus dan meningkatkan pelayanan kepada pasien.

  16. PENULISAN SEJARAH SOSIAL

    Directory of Open Access Journals (Sweden)

    HARIANTI Harianti

    2015-11-01

    sial, studi tentang kota perkotaan atau sejarah sosial kota dan sebagainya. Langkah-langkah penulisan sejarah sosial meliputi empat kegiatan pokok yakni : Heuristik, Kritik, lnterpretasi dan Penyajian. Penulisan sejarah sosial tidak ditulis secara diskriptif, melainkan harus disusun secara analisis agar merupakan penulisan sejarah yang bersifat ilmiah.

  17. Identifikasi Dan Uji Kepekaan Kuman Aerob Pada Alpeolitis Pascapencabutan Gigi

    OpenAIRE

    Rehatta Yongki, Dr.med.dent

    2002-01-01

    Dosen Pada Bagian Konservasi dan Bedah Mulut FKG Unhas Penelitian ini bertujuan untuk mengidentifikasi kuman aerob yang dominan pada alveolitis pascapencabutan gigi dan untuk mengetahui perbedaan kepekaan kuman aerob yang dominan dari Alveolitis terhadap beberapa antiobiotik. Penelitian ini merupakan jenis penelitian deskriftif dan uji laboratorium. Sampel sebanyak 32 orang yang diambil secara Purpose Sampling. Soket diteliti secara cermat, dilakukan pengambilan usapan . Untuk mengiden...

  18. Hubungan antara Pengetahuan dengan Cara Pencegahan Hipertensi pada Lansia di Kecamatan Medan Johor

    OpenAIRE

    Ginting, Firdayani

    2011-01-01

    Hipertensi adalah salah satu penyakit degeneratif yang banyak dialami lansia, yaitu terjadinya peningkatan secara abnormal dan terus menerus tekanan darah yang disebabkan satu atau beberapa faktor yang tidak berjalan sebagaimana mestinya dalam mempertahankan tekanan darah secara normal. Lansia yang kurang pengetahuannya mengenai hipertensi dan upaya yang kurang tepat mempunyai risiko lebih tinggi terjadinya penyakit kardiovaskular. Penelitian ini bertujuan untuk mengetahui gambaran pengeta...

  19. Analisis Pengaruh Faktor Organisasi, Individu, Dan Lingkungan Terhadap Kinerja Karyawan Departemen Front Office Hotel Shangri-la Surabaya

    OpenAIRE

    Yonggara, Natalia; Gresia, Neria

    2014-01-01

    Penelitian ini dilakukan di Hotel Shangri-La Surabaya, terhadap populasi sebanyak 50 responden. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh faktor organisasi, individu, dan lingkungan terhadap kinerja karyawan departemen Front Office. Berdasarkan hasil penelitian, diperoleh pengaruh yang signifikan secara serempak pada faktor organisasi, individu, dan lingkungan terhadap kinerja karyawan. Sedangkan pengaruh yang signifikan secara parsial pada faktor individu dan lingkungan. Fa...

  20. PENGARUH PROFESIONALISME DAN INDEPENDENSI AUDITOR INTERNAL TERHADAP KUALITAS AUDIT: STUDI PADA INSPEKTORAT PROPINSI JAWA BARAT

    Directory of Open Access Journals (Sweden)

    Susilawati Susilawati

    2015-08-01

    Tujuan Penelitian ini adalah: pertama, untuk mengetahui serta menganalisis pengaruh Profesionalisme dan Independensi Auditor Internal secara simultan terhadap kualitas audit pada Inspektorat Provinsi Jawa Barat. Kedua, untuk mengetahui serta menganalisis pengaruh Profesionalisme dan Independensi Auditor Internal secara parsial terhadap kualitas audit pada Inspektorat Provinsi Jawa Barat DOI: 10.15408/etk.v13i2.1886

  1. PERAMALAN PENENTUAN JUMLAH PERMINTAAN KONSUMEN BERBASIS TEKNOLOGI INFORMASI TERHADAP PRODUK BORDIR PADA KOTA TASIKMALAYA

    Directory of Open Access Journals (Sweden)

    Lies Sunarmintyastuti

    2016-12-01

    Full Text Available Peramalan penentuan jumlah permintaan konsumen berbasis teknologi informasi terhadap produk bordir di Kota Tasikmalaya, mempunyai tujuan khusus untuk menentukan jumlah kebutuhan permintaan konsumen secara periodik, berkala dan pola kebutuhan permintaan konsumen dimasa yang akan datang secara trend, musiman. Penelitian ini berawal dari konsep pemikiran bagaimana supaya produsen bordir di Kota Tasikmalaya mendapatkan pendapatan yang optimal dan efisien dalam biaya produksi bordir mereka. Pendekatan peramalan dalam penelitian ini menggunakan metode Time Series dengan menggunakan Single Exponential Smoothing Modeluntuk mendapatkan nilai peramalan secara periodik, Double Exponential Smoothing Modeluntuk mendapatkan nilai peramalan secara trend dan Triple Exponential SmoothingModeldengan Multiplicative Seasonal Modeluntuk mendapatkan nilai peramalan secara musiman, serta pengujian peramalan menggunakan MAD, MAPE dan MSE untuk mencari error terkecil. Pada tahap berikutnya dibangun sebuah sistem peramalan penentuan permintaan konsumen dengan menggunakan metode pengembangan sistem waterfall dan pembuatansoftware yang dirancang menggunakan bahasa pemrograman Java dengan editor NetBeans dan database MySQL.

  2. Aplikasi Short Message Service (SMS dan Email Sebagai Media Komunikasi Data dalam Sistem Pemantauan Suhu

    Directory of Open Access Journals (Sweden)

    Andi Adriansyah

    2011-06-01

    Full Text Available      Sistem pemantauan suhu secara langsung dengan mencatat setiap perubahan suhu secara manual, terlebih pada kondisi suhu yang ekstrim, memiliki resiko yang dapat berakibat fatal. Oleh karena itu dibutuhkan sebuah sistem yang dapat melakukannya secara otomatis. Penelitian ini bertujuan merancang sebuah sistem mandiri yang dapat melakukan pemantauan dan pencatatan perubahan suhu secara near real time (NRT dan mengirimkan laporan secara otomatis melalui email dan SMS. Sistem terdiri dari Sensor suhu LM35 yang berfungsi merubah besaran fisis suhu ke besaran listrik tegangan, Microcontroller Atmega8535 yang memegang peranan untuk mengkonversi tegangan keluaran LM35 kedalam bentuk digital, serta mengirimkan data hasil konversi melalui komunikasi serial ke computer. Program Java yang dijalankan di computer berfungsi memproses data yang dikirim mikrokontroler ATmega8535, menyimpannya ke basis data MySQL, menampilkannya dalam bentuk tabel dan grafik, dan mengirimkan laporan melalui email dan SMS bila data suhu yang diterima melebihi ambang batas yang telah ditentukan.

  3. Alur Kerja Baru Simulasi Performa Bangunan Dalam Proses Desain Parametrik

    Directory of Open Access Journals (Sweden)

    Firza Utama Sjarifudin

    2010-12-01

    Full Text Available Makalah ini menjelaskan hubungan alur kerja baru antara program pemodelan CAD 3D (Rhino/Grasshopper dan simulasi pencahayaan dengan (Radiance/Daysim. Alur kerja perancangan yang sangat efektif dalam Rhino disajikan secara langsung dengan mengekspor geometri, material properties, dan sensor grid ke dalam format Radiance/Daysim untuk menghitung serangkaian indikator performa termasuk peta radiasi matahari serta faktor pendistribusian pencahayaan dalam setahun. Hasil simulasi secara otomatis dikirim kembali ke dalam Rhino menggunakan pemetaan warna. Dengan menggunakan Grasshopper, parameter desain utama seperti ukuran jendela dan deskripsi material dapat diubah secara bertahap dan hasil simulasi dapat dikombinasikan menjadi sebuah simulasi performa bangunan dalam bentuk animasi transformasi parametrik. Desain alur kerja ini telah secara khusus dikembangkan bagi proses perancangan arsitektur dengan menyediakan semua feedback yang sangat berguna bagi perancang secara interaktif dari tahap rancangan skematis sampai tahap pengembangan perancangan. 

  4. MONITORING KEMAJUAN PENGERJAAN PROYEK BELT CONVEYOR PLANT 14 HAMBALANG BERBASIS WEB

    Directory of Open Access Journals (Sweden)

    Juliana Juliana

    2018-04-01

    Full Text Available Kriteria yang harus dipenuhi produk yang dihasilkan dari proyek meliputi kriteria atau batasan waktu, batasan ruang lingkup, batasan biaya dan batasan kualitas. Untuk itu, maka perlu dilakukan monitoring untuk mengetahui kemajuan proyek sehingga keempat kriteria tersebut terpenuhi. Progress atau kemajuan proyek menjadi indikator dalam monitoring untuk menilai perkembangan pelaksanaan pekerjaan dibandingkan dengan rencana. Perkembangan pelaksanaan proyek harus dilaporkan secara periodik. Pada pelaksanaan proyek pembangunan belt conveyor plant 14 Hambalang, PT Unixindo Ekatama Sentana dalam melakukan monitoring perkembangan proyek belum ada sistem pelaporan yang terintegrasi dan pengolahan data masih dilakukan secara manual dengan menggunakan aplikasi Ms.Excel. Dalam penelitian ini dibangun sistem informasi monitoring pelaporan proyek untuk memudahkan monitoring kemajuan proyek. Aplikasi untuk monitoring kemajuan proyek yang dibangun dengan berbasis web menggunakan PHP dan MySQL. Tujuan dari penelitian yang dilakukan yaitu untuk menghasilkan sistem informasi untuk melakukan monitoring kemajuan proyek berbasis web dan tersedia sistem pelaporan kemajuan proyek yang terintegrasi sehingga memudahkanperusahaan dalam memonitoring proyek secara online. Manfaat yang diharapkan dari adanya sistem monitoring kemajuan proyek secara online adalah memudahkan proses monitoring kemajuan proyek yang dapat dilakukan secara online. Dari penelitian dihasilkan sistem informasi monitoring yang dibuat memudahkan pelaporan proyek di lapangan yang dilakukan secara online sehingga perusahaan dapat memonitor kemajuan proyek secara kontinyu dan dapat digunakan untuk menilai perkembangan pekerjaan proyek yang dibandingkan dengan perencanaan proyek sehingga dapat mengambil keputusan untuk melakukan perbaikan. Kata kunci: kemajuan proyek, pelaporan proyek, monitoring proyek berbasis web.

  5. الطريقة التوليفية في تدريس مهارة القراءة للناطقين بغير العربية

    Directory of Open Access Journals (Sweden)

    Rahmadon

    2016-01-01

    Full Text Available Qiraah atau membaca dalam pengajaran bahasa arab merupakan salah satu keterampilan bahasa, membaca secara umum bertujuan agar para siswa mampu mendapatkan informasi secara langsung dari teks dan naskah bacaan dalam bahasa arab. Sehingga seorang dikatakan mampu membaca ketika ia dapat memahami isi bacaan secara sempurna kemudian mampu ‘menerjemahkannya’ dalam pikirannya secara total dan dapat memberikan kesimpulan terhadapa bacaan tersebut. Tentunya kemahiran membaca membutuhkan usaha yang sungguh-sungguh dari diri pembaca itu sendiri. Bagi orang yang tidak berbicara dengan bahasa arab atau siswa non arab, membaca naskah arab memerlukan metode yang tepat untuk bisa sampai pada tujuan pemahaman. Metode pengajaran qiraah yang digunakan guru atau pengajar bagi siswa non Arab harus menjawab permasalahan kesulitan mereka dalam memahami bacaan. Terdapat banyak Metode dalam pengajaran Kemahiran Membaca diantaranya, Metode Tarkibi, Metode Tahlili dan Metode Jumlah, yang kesemuanya tentu saja mempunyai kelebihan dan kekurangan dalam terapannya.Dalam tulisan ini, penulis ingin membahas secara mendetil metode tersebut dengan menyarankan satu metode yang dianggap paling tepat untuk pengajaran qiraah bagi siswa non Arab yaitu yang disebut dengan metode Tulifiyah dimana metode ini sebenarnya adalah hasil penggabungan ketiga metode diatas dari sisi kelebihan dan meminimalisir kekurangan yang dimilikinya. Lebih lanjut akan dibahas tentang detil dari metode ini dari pengertian sampai bagaimana terapannya sehingga membantu guru atau pengajar dalam proses pembelajaran keterampilan membaca secara khusus dan proses pembelajaran bahasa Arab secara umum.

  6. Pendugaan Struktur Patahan Dengan Metode Gaya Berat

    Directory of Open Access Journals (Sweden)

    Ibrahim Sota

    2011-12-01

    Full Text Available Telah dilakukan penelitian tentang pendugaan struktur patahan mengguankan metode gayaberat. Kontras densitas tersebut berasosiasi dengan ketebalan sedimen dan keberadaan struktur patahan atau lipatan. Untuk mengetahui lokasi patahan dan lipatan maka anomali residual terlebih dahulu dipisahkan dari anomali total (anomali Bouguer dengan metode perata-rataan bergerak. Kontur anomali residual memperlihatkan keberadaan lipatan dan patahan secara kualitatif sedangkan interpretasi kuantitatif dengan pemodelan kedepan 2D memperlihatkan secara jelas lokasi patahan. Dari hasil penelitian diperoleh bahwa lokasi patahan/sesar naik berada di bagian timurlaut yang berorientasi baratlaut-tenggara sedangkan patahan/sesar normal tersebar secara lokal yang juga berorientasi baratlaut-tenggara.

  7. A atenção pré-natal na ótica de um grupo de mulheres usuárias do subsetor suplementar La atención prenatal en la óptica de un grupo de mujeres usuarias del subsector suplementar Prenatal care attention in the view of a group of women who use the supplementary subsector

    Directory of Open Access Journals (Sweden)

    Micheli Regina Etges

    2011-03-01

    Full Text Available Este estudo, de abordagem qualitativa, objetivou conhecer a percepção de mulheres que vivenciaram a Atenção Pré-Natal (APN no contexto do Subsetor Suplementar (SS sobre a qualidade desta atenção. Os dados foram coletados através de entrevistas semi-estruturadas e analisados por categorização descritiva. Para as entrevistadas, a APN foi de qualidade, suprindo suas necessidades e expectativas. Acolhimento, vínculo com o profissional, a consequente segurança transmitida e a duração das consultas foram critérios destacados nesta avaliação. Suas experiências sugerem que a APN realizada no SS segue, em parte, as recomendações do Ministério da Saúde (MS e da Organização Mundial da Saúde (OMS. A freqüência das consultas e as orientações fornecidas são aspectos condizentes ao que se recomenda. Os dados sugerem, contudo, que a APN não segue a orientação do MS e da OMS para que seja evitado o uso excessivo de tecnologias duras, como é o caso das ecografias obstétricas.Este estudio, de abordaje cualitativo, objetivó conocer la percepción de mujeres que vivenciaron la Atención Prenatal (APN en el contexto del Subsector Suplementar (SS sobre la calidad de esta atención. Los datos fueron recolectados a través de entrevistas semiestructuradas y analizados por categorización descriptiva. Para las entrevistadas, la APN fue de calidad, supliendo sus necesidades y expectativas. Acogida, vínculo con el profesional, la consecuente seguridad trasmitida y la duración de las consultas fueron criterios destacados en esta evaluación. Sus experiencias sugestionan que la APN realizada en el SS sigue, en parte, las recomendaciones del Ministerio de la Salud (MS y Organización Mundial de la Salud (OMS. La frecuencia de las consultas y las orientaciones fornecidas son aspectos coherentes a lo que se recomienda. Los datos sugestionan, con todo, que la APN no sigue la orientación del MS y de la OMS para que sea evitado el uso

  8. Science.gov (United States)

    Morisset, C.; Delgado-Inglada, G.; Torres-Peimbert, S.

    2014-04-01

    Most - if not all - planetary nebulae exhibit a complex structure, far from the spherical shape. The reasons for this dramatic change in symmetry, that occurs in early stage of the development of the nebula, remain controversial. The same physics operates in a variety of stars, from young (winds from young stars and/or high mass stars) to old (novae, symbiotic stars). The aim of the APN series of conferences has been to offer the opportunity to anyone involved in the study of asymmetric planetary nebulae (and related objects) to discuss the latest results obtained in this field. The APN VI conference was organized by the Instituto de Astronomia (UNAM) and took place on Riviera Maya, Quintana Roo, México, 4-8 Nov. 2013

  9. Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension

    Directory of Open Access Journals (Sweden)

    John W. Wright

    2012-01-01

    Full Text Available The classic renin-angiotensin system (RAS was initially described as a hormone system designed to mediate cardiovascular and body water regulation. The discovery of a brain RAS composed of the necessary functional components (angiotensinogen, peptidases, angiotensins, and specific receptor proteins independent of the peripheral system significantly expanded the possible physiological and pharmacological functions of this system. This paper first describes the enzymatic pathways resulting in active angiotensin ligands and their interaction with AT1, AT2, and mas receptor subtypes. Recent evidence points to important contributions by brain angiotensin III (AngIII and aminopeptidases A (APA and N (APN in sustaining hypertension. Next, we discuss current approaches to the treatment of hypertension followed by novel strategies that focus on limiting the binding of AngII and AngIII to the AT1 receptor subtype by influencing the activity of APA and APN. We conclude with thoughts concerning future treatment approaches to controlling hypertension and hypotension.

  10. Care Coordination for Children with Complex Special Health Care Needs: The Value of the Advanced Practice Nurse’s Enhanced Scope of Knowledge and Practice

    Science.gov (United States)

    Looman, Wendy S.; Presler, Elizabeth; Erickson, Mary M.; Garwick, Ann E.; Cady, Rhonda G.; Kelly, Anne M.; Finkelstein, Stanley M.

    2012-01-01

    Efficiency and effectiveness of care coordination depends on a match between the needs of the population and the skills, scope of practice, and intensity of services provided by the care coordinator. There is limited existing literature that addresses the relevance of the APN role as a fit for coordination of care for children with SHCN. The objective of this paper is to describe the value of the advanced practice nurse’s (APN’s) enhanced scope of knowledge and practice for relationship-based care coordination in healthcare homes that serve children with complex special health care needs (SHCN). The TeleFamilies project is provided as an example of the integration of an APN care coordinator in a healthcare home for children with SHCN. PMID:22560803

  11. A multidisciplinary prostate cancer clinic for newly diagnosed patients: developing the role of the advanced practice nurse.

    Science.gov (United States)

    Madsen, Lydia T; Craig, Catherine; Kuban, Deborah

    2009-06-01

    Newly diagnosed patients with prostate cancer have various treatment options, and a multidisciplinary prostate cancer clinic (MPCC) can present all options in a single setting. An MPCC was started in 2004 at the University of Texas M.D. Anderson Cancer Center, and 258 patients with prostate cancer were evaluated in its first year. The clinic expanded in 2006 and an oncology advanced practice nurse (APN) was recruited to address specific objectives. The APN role was used to implement a quality-of-life protocol, provide detailed patient education (including a treatment summary and care plan), and serve as a single point of contact as patients move toward a treatment decision. Formal evaluation of the MPCC showed that patients were satisfied with this approach to the complex decision-making process in prostate cancer.

  12. Le système d’information sur la biodiversité de l’administration des parcs nationaux argentins

    Directory of Open Access Journals (Sweden)

    Leonidas Lizarraga

    2014-06-01

    Full Text Available Introduction Le système d’information sur la biodiversité (SIB, Sistema de Información de Biodiversidad de l’administration des parcs nationaux argentins (APN, Administración de Parques Nacionales a été lancé en 2002, avec le soutien du Global Environment Fund (GEF dans le cadre du Projet de préservation de la biodiversité mené par l’État argentin. Le dispositif, abrégé en SIB-APN, est composé d’un ensemble de bases de données thématiques et d’un système d’information géographique : son ob...

  13. Maximum credible earthquake (MCE) magnitude of structures affecting the Ujung Lemahabang site

    International Nuclear Information System (INIS)

    Soerjodibroto, M.

    1997-01-01

    This report analyse the geological structures in/around Muria Peninsula that might originating potential earthquake hazard toward the selected site for NPP, Ujung Lemahabang (ULA). Analysis was focused on the Lasem fault and AF-1/AF-4 offshore faults that are considered as the determinant structures affecting the seismicity of ULA (Nira, 1979, Newjec, 1994). Methods for estimating the MCE of the structures include maximum historical earthquake, and relationship between the length of the fault and the magnitude of earthquake originating from the known structure (Tocher, Iida, Matsuda, Wells and Coopersmith). The MCE magnitude estimating by these method for earthquake originating along the Lasem and AF-1/AF-4 faults vary from 2,1M to 7,0M. Comparison between the result of historical data and fault-magnitude relationship, however, suggest a MCE magnitude of Ms=7,0M for both fault zones. (author)

  14. Assessment of Nuclear Power Plant Impact to the Environment: Effect of Sea Water Temperature Increase on Plankton Population

    International Nuclear Information System (INIS)

    Tjahaja, I P; Pujadi; Supriharyono; Aviati, N; Ruswahyun; Busono, H

    1996-01-01

    Research to study the effect of sea water temperature increase on plankton population had been carried out to predict nuclear power plant impact to the environment. Plankton collected from Jepara waters, Muria Peninsula, was grown on growth medium i.e. sea water enriched with silicate fertilizer. Plankton growth was maintained at temperature varied from 34oC to 46oC and the amount of plankton individu was counted twice a day until it was reduced about 95%. The results showed that the reduction of amount of plankton individu occurred on the medium with temperature above the ambient temperature (34oC). The rate of reduction is linear to the temperature increase. There is no plankton survived at temperature above 40oC for more than 24 hours

  15. Geological evaluation of spent fuel storage and low-intermediate level radwaste disposal in the site of NPP candidate

    International Nuclear Information System (INIS)

    Sucipta; Yatim, S.; Martono, H.; Pudyo, A.

    1997-01-01

    Based on the consideration of techno-economy and environmental safety, the radioactive waste treatment installation (RWI), interim storage of spen fuel (ISSF) and low-intermediate level disposal shall be sited in the surrounding of NPP area. The land suitability of NPP's site candidate at Muria Peninsula as spent fuel storage and low-intermediate level radwaste disposal need to be studied. Site selection was conducted by overlay method and scoring method, and based on safety criteria which include geological and environmental aspects. Land evaluation by overlay method has given result a potential site which have highest suitable land at surrounding of borehole L-15 about 17.5 hectares. Land evaluation by scoring method has given result two land suitability classes, i.e. moderate suitability class (includes 14 borehole) and high suitability class, include borehole L-2, L-14 and L-15 (author)

  16. PENENTUAN KOEFISIEN DISPERSI ATMOSFERIK UNTUK ANALISIS KECELAKAAN REAKTOR PWR DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Pande Made Udiyani

    2015-03-01

    Full Text Available Atmosfer merupakan pathway penting pada perpindahan radionuklida yang lepas dari Pembangkit Listrik Tenaga Nuklir (PLTN ke lingkungan dan manusia. Penerimaan dosis pada lingkungan dan manusia dipengaruhi oleh sourceterm dan kondisi tapak PLTN. Untuk mengetahui penerimaan dosis lingkungan untuk PLTN di Indonesia, maka diperlukan nilai koefisien dispersi untuk tapak potensial yang dipilih. Model perhitungan dalam penelitian ini menggunakan model yang diterapkan pada paket program pada