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Sample records for multiple beam-line elements

  1. The Fluka Linebuilder and Element Database: Tools for Building Complex Models of Accelerators Beam Lines

    CERN Document Server

    Mereghetti, A; Cerutti, F; Versaci, R; Vlachoudis, V

    2012-01-01

    Extended FLUKA models of accelerator beam lines can be extremely complex: heavy to manipulate, poorly versatile and prone to mismatched positioning. We developed a framework capable of creating the FLUKA model of an arbitrary portion of a given accelerator, starting from the optics configuration and a few other information provided by the user. The framework includes a builder (LineBuilder), an element database and a series of configuration and analysis scripts. The LineBuilder is a Python program aimed at dynamically assembling complex FLUKA models of accelerator beam lines: positions, magnetic fields and scorings are automatically set up, and geometry details such as apertures of collimators, tilting and misalignment of elements, beam pipes and tunnel geometries can be entered at user’s will. The element database (FEDB) is a collection of detailed FLUKA geometry models of machine elements. This framework has been widely used for recent LHC and SPS beam-machine interaction studies at CERN, and led to a dra...

  2. High peak current operation of x-ray free-electron laser multiple beam lines by suppressing coherent synchrotron radiation effects

    Science.gov (United States)

    Hara, Toru; Kondo, Chikara; Inagaki, Takahiro; Togawa, Kazuaki; Fukami, Kenji; Nakazawa, Shingo; Hasegawa, Taichi; Morimoto, Osamu; Yoshioka, Masamichi; Maesaka, Hirokazu; Otake, Yuji; Tanaka, Hitoshi

    2018-04-01

    The parallel operation of multiple beam lines is an important means to expand the opportunity of user experiments at x-ray free-electron laser (XFEL) facilities. At SPring-8 Angstrom free-electron laser (SACLA), the multi-beam-line operation had been tested using two beam lines, but transverse coherent synchrotron radiation (CSR) effects at a dogleg beam transport severely limited the laser performance. To suppress the CSR effects, a new beam optics based on two double bend achromat (DBA) structures was introduced for the dogleg. After the replacement of the beam optics, high peak current bunches of more than 10 kA are now stably transported through the dogleg and the laser pulse output is increased by a factor of 2-3. In the multi-beam-line operation of SACLA, the electron beam parameters, such as the beam energy and peak current, can be adjusted independently for each beam line. Thus the laser output can be optimized and wide spectral tunability is ensured for all beam lines.

  3. Status of ACCULINNA beam line

    CERN Document Server

    Rodin, A M; Bogdanov, D D; Golovkov, M S; Fomichev, A S; Sidorchuk, S I; Slepnev, R S; Wolski, R; Ter-Akopian, G M; Oganessian, Yu T; Yukhimchuk, A A; Perevozchikov, V V; Vinogradov, Yu I; Grishenchkin, S K; Demin, A M; Zlatoustovskii, S V; Kuryakin, A V; Filchagin, S V; Ilkaev, R I

    2003-01-01

    The separator ACCULINNA was upgraded to achieve new experimental requirements. The beam line was extended by new ion-optical elements beyond the cyclotron hall. The new arrangements yield much better background conditions. The intensities of sup 6 He and sup 8 He radioactive beams produced in fragmentation of 35 A MeV sup 1 sup 1 B ions were increased up to a factor of 10. The upgraded beam line was used in experiments to study the sup 5 H resonance states populated in the t+t reaction. A cryogenic liquid tritium target was designed and installed at the separator beam line.

  4. SLIA beam line design

    International Nuclear Information System (INIS)

    Petillo, J.; Chernin, D.; Kostas, C.; Mondelli, A.

    1990-01-01

    The Spiral Line Induction Accelerator (SLIA) is a multi-kiloampere compact electron accelerator. It uses linear induction accelerator modules on the straight sections of a racetrack spiral, with strong-focusing bends to recirculate the electrons. The strong focusing is provided by stellarator windings on the bends. Stellarator coils are used to provide the strong focusing on the bends. The matching of the electron beam from a diode through a series of accelerator modules and stellarator bends is a major issue in the design of this accelerator. The beam line design for a proof-of-concept SLIA experiment (10 kA, 7 MeV) to be carried out at Pulse Sciences, Inc. will be presented. The design will demonstrate beam matching from element to element in the focusing system, the design of an achromatic bend, and the requirements for avoiding collective instabilities

  5. Standardization of beam line representations

    International Nuclear Information System (INIS)

    Carey, David C.

    1998-01-01

    Standardization of beam line representations means that a single set of data can be used in many situations to represent a beam line. This set of data should be the same no matter what the program to be run or the calculation to be made. We have concerned ourselves with three types of standardization: (1) The same set of data should be usable by different programs. (2) The inclusion of other items in the data, such as calculations to be done, units to be used, or preliminary specifications, should be in a notation similar to the lattice specification. (3) A single set of data should be used to represent a given beam line, no matter what is being modified or calculated. The specifics of what is to be modified or calculated can be edited into the data as part of the calculation. These three requirements all have aspects not previously discussed in a public forum. Implementations into TRANSPORT will be discussed

  6. Standardization of beam line representations

    International Nuclear Information System (INIS)

    Carey, David C.

    1999-01-01

    Standardization of beam line representations means that a single set of data can be used in many situations to represent a beam line. This set of data should be the same no matter what the program to be run or the calculation to be made. We have concerned ourselves with three types of standardization: (1) The same set of data should be usable by different programs. (2) The inclusion of other items in the data, such as calculations to be done, units to be used, or preliminary specifications, should be in a notation similar to the lattice specification. (3) A single set of data should be used to represent a given beam line, no matter what is being modified or calculated. The specifics of what is to be modified or calculated can be edited into the data as part of the calculation. These three requirements all have aspects not previously discussed in a public forum. Implementations into TRANSPORT will be discussed

  7. Design of the ESCAR injection beam line

    International Nuclear Information System (INIS)

    Tanabe, J.; Staples, J.; Yourd, R.

    1975-01-01

    The design features of the elements of the ESCAR (Experimental Superconducting Accelerator Ring) injection beam line are described. The junction of the proton transport system with the ESCAR injection straight section requires the design of mechanical elements compatible with the 10 -11 torr vacuum requirements of the main ring. These elements include a novel septum magnet whose salient design features include a current-carrying septum of tapered thicknesses to reduce the overall power requirements and total enclosure of the magnet coil in a metal can for vacuum compatibility. Other elements are a wire electro-static septum and several fast-rise ''bump magnets''. A transition cryopump is designed to separate the main ring vacuum from the relatively poor 10 -6 torr vacuum of the conventional beam transport line. A brief description of the conventional beam transport line from the 50 MeV proton linac, recently installed for Bevatron injection,is also included. (U.S.)

  8. Optics calculations and beam line design for the JANNuS facility in Orsay

    International Nuclear Information System (INIS)

    Chauvin, N.; Henry, S.; Flocard, H.; Fortuna, F.; Kaitasov, O.; Pariset, P.; Pellegrino, S.; Ruault, M.O.; Serruys, Y.; Trocelier, P.

    2007-01-01

    JANNuS (Joint Accelerators for Nano-Science and Nuclear Simulation) will be a unique user facility in Europe dedicated to material modification by ion beam implantation and irradiation. The main originality of the project is that it will be possible to perform implantation and irradiation with simultaneous multiple ions beams and in situ characterization by transmission electron microscopy (TEM) observation or ion beam analysis. This facility will be composed of two experimental platforms located in two sites: the CEA-SRMP in Saclay and the CNRS-CSNSM in Orsay. This paper will focus on the design of two new transport beam lines for the Orsay site. One of the most challenging parts of the JANNuS project (Orsay site) is to design two new beam lines in order to inject, into a 200 kV TEM, two different ion beams (low and medium energy) coming from two existing pieces of equipment: a 2 MV Tandem accelerator and a 190 kV ion implanter. For these new beam lines, first order beam calculations have been done using transfer matrix formalism. A genetic algorithm has been written and adapted to perform the optimization of the beam line parameters. Then, using the SIMION code, field maps of the electrostatic elements (quadrupoles, spherical sectors) have been calculated and ion trajectories have been simulated. We studied specifically the optical aberrations induced by the electrostatic spherical deflectors. Finally, the results of the first order calculations and the field map simulations show a good agreement

  9. The appearance of beam lines

    International Nuclear Information System (INIS)

    Carey, D.C.

    1993-05-01

    The combination of an existing graphics package with a large program like TRANSPORT has often resulted in considerable modification to the large program. Use of other graphics package has resulted in essentially having to repeat the work. This difficulty has been avoided in a modification of TRANSPORT which produce layouts of beam lines. Drawings of the reference trajectory and three-dimensional images of all magnets are made by the graphics package TOP DRAWER. Nothing specific to TOP DRAWER or any other graphics has been incorporated into TRANSPORT. If a user is with a different graphics package he or she can then begin usage of this alternate package essentially immediately

  10. Beam line design using G4BeamLine

    CERN Document Server

    Dogan, Arda

    2014-01-01

    In Turkey in Ankara TAEK SANAEM Proton Accelerator Facility (PAF), there is a cyclotron which produces a focused intense 30 MeV proton beam and sends this beam to four different arms, three of which uses this beam to produce pharmaceutical medicine. The remaining one is spared for R&D purposes and the idea was to use these protons coming out from the fourth arm to use space radiation tests, which cannot be done in Turkey at the moment. However, according to SCC 25100 standards which is for 30 MeV protons, the beam coming out of cyclotron is too intense and focused to use for space radiation tests. Therefore, the main aim of my project is to design a beam line which will defocus the beam and reduce the flux so that the space radiation tests can be done according to the standards of SCC 25100.

  11. Modification of beam lines at VEC

    Energy Technology Data Exchange (ETDEWEB)

    Shoor, Bivas; Chakraborty, P S; Mallik, C; Bhandari, R K [Variable Energy Cyclotron Centre, Calcutta (India)

    1997-12-01

    From the experience of light ion beam transportation through the Variable Energy Cyclotron beam line, it was observed that the beam line performance has to be improved in view of heavy ion acceleration program at the centre. The aim of this work was to study the feasibility of reducing the number of operational parameters without hampering the beam transmission and at the same time, to improve the vacuum of the beam line by reducing the hardware 2 refs., 1 fig.

  12. Simulating the Beam-line at CERN's ISOLDE Experiment

    CERN Document Server

    McGrath, Casey

    2013-01-01

    Maximizing the optical matching along portions of the ISOLDE beam-line and automating this procedure will make it easier for scientists to determine what the strengths of the electrical elds of each beam-line element should be in order to reduce particle loss. Simulations are run using a program called MAD-X, however, certain issues were discovered that hindered an immediate success of the simulations. Specifically, the transfer matrices for electrostatic components like the switchyards, kickers, and electric quadrupoles were missing from the original coding. The primary aim of this project was to design these components using AutoCAD and then extract the transfer matrices using SIMION. Future work will then implement these transfer matrices into the MAD-X code to make the simulations of the beam-line more accurate.

  13. BEAM LINE DESIGN FOR THE CERN HIRADMAT TEST FACILITY

    CERN Document Server

    Hessler, C; Goddard, B; Meddahi, M; Weterings, W

    2009-01-01

    The LHC phase II collimation project requires beam shock and impact tests of materials used for beam intercepting devices. Similar tests are also of great interest for other accelerator components such as beam entrance/exit windows and protection devices. For this purpose a dedicated High Radiation Material test facility (HiRadMat) is under study. This facility may be installed at CERN at the location of a former beam line. This paper describes the associated beam line which is foreseen to deliver a 450 GeV proton beam from the SPS with an intensity of up to 3×1013 protons per shot. Different beam line designs will be compared and the choice of the beam steering and diagnostic elements will be discussed, as well as operational issues.

  14. Beam Line Design for the CERN Hiradmat Test Facility

    CERN Document Server

    Hessler, C; Goddard, B; Meddahi, M; Weterings, W

    2010-01-01

    The LHC phase II collimation project requires beam shock and impact tests of materials used for beam intercepting devices. Similar tests are also of great interest for other accelerator components such as beam entrance/exit windows and protection devices. For this purpose a dedicated High Radiation Material test facility (HiRadMat) is under study. This facility may be installed at CERN at the location of a former beam line. This paper describes the associated beam line which is foreseen to deliver a 450 GeV proton beam from the SPS with an intensity of up to 3×10**13 protons per shot. Different beam line designs will be compared and the choice of the beam steering and diagnostic elements will be discussed, as well as operational issues.

  15. Water-cooled beam line components at LAMPF

    International Nuclear Information System (INIS)

    Grisham, D.L.; Lambert, J.E.

    1981-01-01

    The beam line components that comprise the main experimental beam at the Clinton P. Anderson Meson Physics Facility (LAMPF) have been operating since February 1976. This paper will define the functions of the primary water-cooled elements, their design evolution, and our operating experience to the present time

  16. Some aspects of VUV beam line design

    International Nuclear Information System (INIS)

    Gaupp, A.; Peatman, W.

    1997-01-01

    Some aspects of the design and usage of vacuum ultraviolet beam lines are discussed. Fermat's principle for imaging is introduced and applied to grating monochromators. Some typical vacuum ultraviolet beam lines are presented, and some further topics believed to be of importance today and in the future are mentioned. (author)

  17. A specialized bioengineering ion beam line

    International Nuclear Information System (INIS)

    Yu, L.D.; Sangyuenyongpipat, S.; Sriprom, C.; Thongleurm, C.; Suwanksum, R.; Tondee, N.; Prakrajang, K.; Vilaithong, T.; Brown, I.G.; Wiedemann, H.

    2007-01-01

    A specialized bioengineering ion beam line has recently been completed at Chiang Mai University to meet rapidly growing needs of research and application development in low-energy ion beam biotechnology. This beam line possesses special features: vertical main beam line, low-energy (30 keV) ion beams, double swerve of the beam, a fast pumped target chamber, and an in-situ atomic force microscope (AFM) system chamber. The whole beam line is situated in a bioclean environment, occupying two stories. The quality of the ion beam has been studied. It has proved that this beam line has significantly contributed to our research work on low-energy ion beam biotechnology

  18. The elettra beam line control system

    International Nuclear Information System (INIS)

    Mignacco, M.; Abrami, A.; Dequal, Z.

    1994-01-01

    Elettra is a third generation Synchrotron Light Source located in Trieste (Italy). It consists of a full energy linac injector and a storage ring with beam energies between 1.5 and 2 GeV. The facility is scheduled to be operational by end 1993. For the whole project 22 beam lines from insertion devices are foreseen, each of them is composed of a large number of measurement and controls instruments, most of them embedded in intelligent devices; in addition each beam line can be considered unique compared to the others, having been designed to provide a different kind of synchrotron radiation. This results in a large not homogenous environment where more than 200,000 physical points have to be controlled. A joint team composed of Softeco Sismat and Digital Equipment has developed a fully automated beam line control system able to give full remote controls, with different kind of access rights, to beam line users and beam line specialists as well as a full integration with experiment control systems. ((orig.))

  19. Duration judgements over multiple elements

    Directory of Open Access Journals (Sweden)

    Inci eAyhan

    2012-11-01

    Full Text Available We investigated the limits of the number of events observers can simultaneously time. For single targets occurring in one of eight positions sensitivity to duration was improved for spatially pre-cued items as compared to post-cued items indicating that exogenous driven attention can improve duration discrimination. Sensitivity to duration for pre-cued items was also marginally better for single items as compared to eight items indicating that even after the allocation of focal attention, distracter items can interfere with the encoding of duration. For an eight item array discrimination was worse for post-cued locations as compared to pre-cued locations indicating both that attention can improve duration discrimination performance and that it was not possible to access a perfect memory trace of the duration of eight elements. The interference from the distracters in the pre-cued eight item array may reflect some mandatory averaging of target and distracter events. To further explore duration averaging we asked subjects to explicitly compare average durations of multiple item arrays against a single item standard duration. Duration discrimination thresholds were significantly lower for single elements as compared to multiple elements, showing that averaging, either automatically or intentionally, impairs duration discrimination. There was no set size effect. Performance was the same for averages of two and eight items, but performance with even an average of two items was worse than for one item. This was also true for sequential presentation indicating poor performance was not due to limits on the division of attention across items. Rather performance appears to be limited by an inability to remember or aggregate duration information from two or more items. Although it is possible to manipulate perceived duration locally, there appears to be no perceptual mechanisms for aggregating local durations across space.

  20. Beam line for Schools: beyond expectations

    CERN Multimedia

    Cian O'Luanaigh

    2014-01-01

    Out of 292 proposals for CERN's first ever "Beam line for Schools" contest, two teams of high-school students – Odysseus' Comrades from Varvakios Pilot School in Athens, Greece and Dominicuscollege from Dominicus College in Nijmegen in the Netherlands – were selected to spend 10 days conducting their proposed experiments at the fully equipped T9 beam line on CERN's Meyrin site. Dedicated CERN staff and users from across the departments have put in a huge effort to ensure the success of the project.   Detector physicist Cenk Yidriz (centre, white helmet) explains the setup of the "Beamline for schools" experiment at the T9 beamline. It's finally beam time. After months of organisation, coding, engineering and even painting the experimental area, the T9 beam line is ready to deliver protons to experiments devised and built by high-school students. “They are here to collect data and experience the l...

  1. A directly heated electron beam line source

    International Nuclear Information System (INIS)

    Iqbal, M.; Masood, K.; Rafiq, M.; Chaudhry, M.A.

    2002-05-01

    A 140-mm cathode length, Electron Beam Line Source with a high degree of focusing of the beam is constructed. The design principles and basic characteristic considerations for electron beam line source consists of parallel plate electrode geometric array as well as a beam power of 35kW are worked out. The dimensions of the beam at the work site are 1.25xl00mm. The gun is designed basically for the study of evaporation and deposition characteristic of refractory metals for laboratory use. However, it may be equally used for melting and casting of these metals. (author)

  2. Beam line from straight-section 16

    CERN Multimedia

    CERN PhotoLab

    1971-01-01

    The start of a long trail. The beam line from straight-section 16, where protons are fast ejected, is seen at the point where it crosses the Linac shielding wall as it leaves the PS en route to the ISR.

  3. Thermal problems on high flux beam lines

    International Nuclear Information System (INIS)

    Avery, R.T.

    1983-09-01

    Wiggler and undulator magnets can provide very intense photon flux densities to beam line components. This paper addresses some thermal/materials consequences due to such impingement. The LBL/Exxon/SSRL hybrid-wiggler Beam Line VI now nearing operation will be able to provide up to approx. 7 kW of total photon power at planned SPEAR operating conditions. The first masks are located at 6.5 meters from the source and may receive a peak power density (transverse to the beam) exceeding 20 kW/cm 2 . Significantly, this heat transfer rate exceeds that radiated from the sun's surface (7 kW/cm 2 ) and is comparable to that of welding torches. Clearing, cooling and configuration are of critical importance. Configurations for the first fixed mask, the movable mask, and the pivot mask on this beam line are presented together with considerations of thermal stress fatigue and of heat transfer by conduction to water-cooling circuits. Some preliminary information on heating of crystals and mirrors is also presented

  4. REQUIREMENTS AND GUIDELINES FOR NSLS EXPERIMENTAL BEAM LINE VACUUM SYSTEMS-REVISION B.

    Energy Technology Data Exchange (ETDEWEB)

    FOERSTER,C.

    1999-05-01

    Typical beam lines are comprised of an assembly of vacuum valves and shutters referred to as a ''front end'', optical elements to monochromatize, focus and split the photon beam, and an experimental area where a target sample is placed into the photon beam and data from the interaction is detected and recorded. Windows are used to separate sections of beam lines that are not compatible with storage ring ultra high vacuum. Some experimental beam lines share a common vacuum with storage rings. Sections of beam lines are only allowed to vent up to atmospheric pressure using pure nitrogen gas after a vacuum barrier is established to protect ring vacuum. The front end may only be bled up when there is no current in the machine. This is especially true on the VUV storage ring where for most experiments, windows are not used. For the shorter wavelength, more energetic photons of the x-ray ring, beryllium windows are used at various beam line locations so that the monochromator, mirror box or sample chamber may be used in a helium atmosphere or rough vacuum. The window separates ring vacuum from the environment of the downstream beam line components. The stored beam lifetime in the storage rings and the maintenance of desirable reflection properties of optical surfaces depend upon hydrocarbon-free, ultra-high vacuum systems. Storage ring vacuum systems will operate at pressures of {approximately} 1 x 10{sup {minus}10} Torr without beam and {approximately} 1 x 10{sup {minus}9} Torr with beam. Systems are free of hydrocarbons in the sense that no pumps, valves, etc. containing organics are used. Components are all-metal, chemically cleaned and bakeable. To the extent that beam lines share a common vacuum with the storage ring, the same criteria will hold for beam line components. The design philosophy for NSLS beam lines is to use all-metal, hydrocarbon-free front end components and recommend that experimenters use this approach for common vacuum hardware

  5. REQUIREMENTS AND GUIDELINES FOR NSLS EXPERIMENTAL BEAM LINE VACUUM SYSTEMS-REVISION B

    International Nuclear Information System (INIS)

    FOERSTER, C.

    1999-01-01

    Typical beam lines are comprised of an assembly of vacuum valves and shutters referred to as a ''front end'', optical elements to monochromatize, focus and split the photon beam, and an experimental area where a target sample is placed into the photon beam and data from the interaction is detected and recorded. Windows are used to separate sections of beam lines that are not compatible with storage ring ultra high vacuum. Some experimental beam lines share a common vacuum with storage rings. Sections of beam lines are only allowed to vent up to atmospheric pressure using pure nitrogen gas after a vacuum barrier is established to protect ring vacuum. The front end may only be bled up when there is no current in the machine. This is especially true on the VUV storage ring where for most experiments, windows are not used. For the shorter wavelength, more energetic photons of the x-ray ring, beryllium windows are used at various beam line locations so that the monochromator, mirror box or sample chamber may be used in a helium atmosphere or rough vacuum. The window separates ring vacuum from the environment of the downstream beam line components. The stored beam lifetime in the storage rings and the maintenance of desirable reflection properties of optical surfaces depend upon hydrocarbon-free, ultra-high vacuum systems. Storage ring vacuum systems will operate at pressures of ∼ 1 x 10 -10 Torr without beam and ∼ 1 x 10 -9 Torr with beam. Systems are free of hydrocarbons in the sense that no pumps, valves, etc. containing organics are used. Components are all-metal, chemically cleaned and bakeable. To the extent that beam lines share a common vacuum with the storage ring, the same criteria will hold for beam line components. The design philosophy for NSLS beam lines is to use all-metal, hydrocarbon-free front end components and recommend that experimenters use this approach for common vacuum hardware downstream of front ends. O-ring-sealed valves, if used, are not

  6. New wiggler beam line for SSRL

    International Nuclear Information System (INIS)

    Hoyer, E.

    1982-08-01

    A new high-intensity-beam line with a wiggler magnet source is described. This project, in final stages of design, is a joint effort between Lawrence Berkeley Laboratory (LBL), the Exxon Research and Engineering Company (EXXON), and the Stanford Synchrotron Radiation Laboratory (SSRL). Installation at SSRL will begin in the summer of 1982. The goal of this project is to provide extremely high-brightness synchrotron radiation beams over a broad spectral range from 50 eV to 40 keV. The radiation source is a 27 period (i.e., 55 pole) permanent magnet wiggler of a new design. The wiggler utilizes rare-earth cobalt (REC) material in the steel hybrid configuration to achieve high magnetic fields with short periods. An analysis has been made of the polarization, angular distribution and power density of the radiation produced by the wiggler. Details of the wiggler design are presented. The magnet is outside a thin walled (1mm) variable gap stainless steel vacuum chamber. The chamber gap will be opened to 1.8 cm for beam injection into SPEAR and then closed to 1.0 cm (or less) for operation. Five remotely controlled drives are provided; to change the wiggler gap, to change the vacuum chamber aperture and to position the wiggler. Details of the beam line optics and end stations are presented. Thermal loading on beam line components is severe. The peak power density at 7.5 m is 5 kW/cm 2 for the nominal wiggler field and present SPEAR beam currents and will approach 20 kW/cm 2 with the maximum wiggler field and projected SPEAR beam currents

  7. Synthesis of Beam Lines with Necessary Properties

    CERN Document Server

    Andrianov, Serge

    2005-01-01

    In this paper a new approach to the problem of synthesis of beam lines is discussed. Usually this problem can be overcome by the use of numerical simulation and optimal control theory methods. But this results in sufficiently great number of variable parameters and functions. Obviously, that this degrades quality of a modeling procedure. The suggested approach is demonstrated on a problem of a microprobe design problem. Essence of the problem is that necessary to design a high precision focusing system which satisfies some additional conditions. For solution of this problem we use an algebraic treatment based on Lie algebraic methods and computer algebra techniques. Using the symmetry ideology this approach allows rewriting beam properties to enough simple conditions for control parameters and functions. This leads a set of desired solutions and show results in some most suitable form. Moreover, this approach decreases the number of variable parameters.

  8. Design process and modeling studies of SSRL beam line wunder

    International Nuclear Information System (INIS)

    Bachrach, R.Z.; Bringans, R.D.

    1984-01-01

    SSRL Beam Line Wunder will be the first soft X-ray energy range synchrotron radiation beam line specifically designed to exploit the unique aspects of periodic insertion devices in the wiggler-undulator (wunder) regime. Aspects of the development of this beam line are described in this paper and in particular, we discuss the design methodology adopted and emphasize the joint optical, thermal and mechanical optimization studies that were required. (orig.)

  9. Implementation of EPICS based Control System for Radioisotope Beam line

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae-Ha; Ahn, Tae-Sung; Song, Young-Gi; Kwon, Hyeok-Jung; Cho, Yong-Sub [Korea Atomic Energy Research Institute, Gyeongju (Korea, Republic of)

    2015-10-15

    Korea Mult-purpose Accelerator Complex (KOMAC) has been operating 100 MeV proton linear accelerator . For operating 100 MeV linac, various control system has been implemented such as vacuum, power supply, RCCS and etc. KOMAC is operating two beam lines so that clients can use 100 MeV proton beam for their experiment. KOMAC sends beam to beam line and target room using two dipole magnets and several quadrupole magnets. As demand for experiments and Radius Isotope using beam is increased, another beam line is under construction and RI beam line control system is need. To synchronize with KOMAC control system, RI beam line control system is based on Experimental Physics and Industrial control System (EPICS) software. The beam is transported to RI beam line to control magnet power supply and vacuum. Implementation of RI beam line control system is presented and some preliminary results are reported. The base RI beam line control system is implemented. It can control beam direction and vacuum. Comparing archived data and current data, RI beam line and control system will be improved. In the future, scroll pump and gate control system will be implemented using programmable logic controller PLC. RI beam interlock sequence will be added to KOMAC interlock system to protect linac.

  10. Magnet power supply and beam line control for a secondary beam line K6

    International Nuclear Information System (INIS)

    Suzuki, Y.; Takasaki, M.; Minakawa, M.; Ishii, H.; Kato, Y.; Ieiri, M.; Tanaka, K.H.; Noumi, H.; Yamanoi, Y.

    1992-01-01

    K6 is a secondary separated-beam line with momentum range up to 2.0 GeV/c in the north experimental hall at the KEK 12 GeV Proton Synchrotron (KEK-PS). On the construction, newly developed magnet power supplies (MPSs), in each of them a microprocessor is embedded, are introduced. The features of the MPS are as follows: 1, The MPS is connected to an upper-level beam line controller (BLC) by GPIB highway for exchanging simple messages. 2, All the operations of the MPS are supervised by the microprocessor, which has its individual parameters and fault messages. It reduces the load of the upper-level controller. 3, The MPS has functions to inspect itself and to report the result. It saves much time and labor of maintenance. (author)

  11. Redox flow batteries having multiple electroactive elements

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Wei; Li, Liyu; Yang, Zhenguo; Nie, Zimin

    2018-05-01

    Introducing multiple redox reactions with a suitable voltage range can improve the energy density of redox flow battery (RFB) systems. One example includes RFB systems utilizing multiple redox pairs in the positive half cell, the negative half cell, or in both. Such RFB systems can have a negative electrolyte, a positive electrolyte, and a membrane between the negative electrolyte and the positive electrolyte, in which at least two electrochemically active elements exist in the negative electrolyte, the positive electrolyte, or both.

  12. An Energy-Stabilized Varied-Line-Space-Monochromator Undulator Beam Line for PEEM Illumination and Magnetic Circular Dichroism

    International Nuclear Information System (INIS)

    Warwick, Tony; McKinney, Wayne; Domning, Ed; Doran, Andrew; Padmore, Howard

    2006-01-01

    A new undulator beam line has been built and commissioned at the Advanced Light Source for illumination of the PEEM3 microscope. The beam line delivers high flux beams over an energy range from C1s through the transition metals to include the M edges of the magnetic rare earth elements. We present details of the optical design, and data on the performance of the zero-order tracking of the photon energy

  13. 750 keV beam line construction at the KEK

    International Nuclear Information System (INIS)

    Ishimaru, H.; Anami, S.; Inagaki, T.; Sakaue, T.; Itoh, K.; Fukumoto, S.

    1976-01-01

    The construction of 750 keV beam line of the KEK injector of the 12 GeV proton synchrotron was described. The beam line consists of the beam focusing quadrupoles, vacuum system, the electrostatic chopper and the various beam monitors. (author)

  14. High spin isomer beam line at RIKEN

    Energy Technology Data Exchange (ETDEWEB)

    Kishida, T.; Ideguchi, E.; Wu, H.Y. [Institute of Physical and Chemical Research, Saitama (Japan)] [and others

    1996-12-31

    Nuclear high spin states have been the subject of extensive experimental and theoretical studies. For the production of high spin states, fusion reactions are usually used. The orbital angular momentum brought in the reaction is changed into the nuclear spin of the compound nucleus. However, the maximum induced angular momentum is limited in this mechanism by the maximum impact parameter of the fusion reaction and by the competition with fission reactions. It is, therefore, difficult to populate very high spin states, and as a result, large {gamma}-detector arrays have been developed in order to detect subtle signals from such very high spin states. The use of high spin isomers in the fusion reactions can break this limitation because the high spin isomers have their intrinsic angular momentum, which can bring the additional angular momentum without increasing the excitation energy. There are two methods to use the high spin isomers for secondary reactions: the use of the high spin isomers as a target and that as a beam. A high spin isomer target has already been developed and used for several experiments. But this method has an inevitable shortcoming that only {open_quotes}long-lived{close_quotes} isomers can be used for a target: {sup 178}Hf{sup m2} (16{sup +}) with a half-life of 31 years in the present case. By developing a high spin isomer beam, the authors can utilize various short-lived isomers with a short half-life around 1 {mu}s. The high spin isomer beam line of RIKEN Accelerator Facility is a unique apparatus in the world which provides a high spin isomer as a secondary beam. The combination of fusion-evaporation reaction and inverse kinematics are used to produce high spin isomer beams; in particular, the adoption of `inverse kinematics` is essential to use short-lived isomers as a beam.

  15. Beam line for experiments with coherent soft x-rays

    International Nuclear Information System (INIS)

    Howells, M.R.; Kirz, J.; Krinsky, S.

    1982-12-01

    The advantages of coherent soft x-rays for three-dimensional imaging of biological specimens are discussed, the x-ray source requirements are described, and the general design of the beam line and its optical system are given

  16. Vaccum and beam diagnostic controls for ORIC beam lines

    International Nuclear Information System (INIS)

    Tatum, B.A.

    1991-01-01

    Vacuum and beam diagnostic equipment on beam lines from the Oak Ridge Isochronous Cyclotron, ORIC, is now controlled by a new dedicated system. The new system is based on an industrial programmable logic controller with an IBM AT personal computer providing control room operator interface. Expansion of this system requires minimal reconfiguration and programming, thus facilitating the construction of additional beam lines. Details of the implementation, operation, and performance of the system are discussed. 2 refs., 2 figs

  17. Insertion device and beam line plans for the Advanced Photon Source: A report and recommendations by the Insertion Device and Beam Line Planning Committee

    International Nuclear Information System (INIS)

    1988-02-01

    In the 7-GeV Advanced Photon Source (APS) Conceptual Design Report (CDR), fifteen complete experimental beam lines were specified in order to establish a representative technical and cost base for the components involved. In order to optimize the composition of the insertion devices and the beam line, these funds are considered a ''Trust Fund.'' The present report evaluates the optimization for the distribution of these funds so that the short- and long-term research programs will be most productive, making the facility more attractive from the user's point of view. It is recommended that part of the ''Trust Fund'' be used for the construction of the insertion devices, the front-end components, and the first-optics, minimizing the cost to potential users of completing a beam line. In addition, the possibility of cost savings resulting from replication and standardization of high multiplicity components (such as IDs, front ends, and first-optics instrumentation) is addressed. 2 refs., 5 tabs

  18. Beam Optics for Typical Part of ISOL Beam Lines

    International Nuclear Information System (INIS)

    Jang, Ji Ho; Kwon, Hyeok Jung; Kim, Han Sung; Cho, Yong Sub

    2013-01-01

    KOMAC (Korea Multi-purpose Accelerator Complex) is doing a project, the detailed design of the ISOL beam lines for the heavy ion accelerator project of IBS (Institute of Basic Science) from August 2013 to February 2014. The heavy ion beams are transported by using the electrostatic quadrupoles and electrostatic benders between the equipment. The work-scope of the project is the beam optics design of the beam lines and the detailed design of the beam optics components, the electrostatic quadrupoles and the electrostatic bender. This work summarized the initial result of beam optics design of the beam line. We performed the beam optics simulation in two regions of ISOL beam lines and found that beam envelope is less than 2 cm. We will check that the poletip file values are reasonable or not in near future, and we also applied this method to the other parts of the ISOL beam line and optimize them. The result will be used the detailed design of the electrostatic quadrupoles and benders

  19. New development of hadron physics at new laser electron beam line (LEP2) of SPring-8

    International Nuclear Information System (INIS)

    Muramatsu, Norihito; Niiyama, Masayuki; Yosoi, Masaru

    2015-01-01

    This paper introduces the outline of LEPS2 beam line and two types of large detectors (electromagnetic calorimeter BGOegg and solenoid spectrometer), LEPS2/BGOegg experiment, and the target physics using LEPS2 solenoid spectrometer. In LEPS2 beam line, experiments are performed with the improvement of beam intensity by nearly one digit due to the simultaneous incidence of multiple lasers of high output, as well as with the installation of a large solid angle high-resolution detector. In LEPS2/BGOegg experiment, direct observation with a large solid angle of mesons such as π 0 , η, η', and ω has become possible, which has given expectation for new physics. As one of the physics at the core of BGOegg experiments, there is the systematic examination of interaction between η' and nucleus/nucleon. In the physics using a solenoid spectrometer, the first target is the measurement of penta-quark particle Θ + . (A.O.)

  20. Development of an Ethernet enabled microcontroller based module for Superconducting Cyclotron ECR beam line control

    International Nuclear Information System (INIS)

    Chatterjee, M.; Koley, D.; Nabhiraj, P.Y.

    2012-01-01

    An Ethernet enabled control and data acquisition module is developed for remote control and monitoring of the ECR beam line equipment of the Superconducting Cyclotron. The PIC microcontroller based module supports multiple general purpose analog and digital inputs and outputs for interfacing with various equipments and an embedded web server. The remote monitoring and control of the equipment are achieved through the web based user interface. The user authenticated access to control parameters and module configuration parameters ensures the operational safety of the equipment under control. This module is installed in Superconducting Cyclotron ECR beam line for the control and monitoring of vacuum pumping modules, comprising of pumps, gate valves and dual vacuum gauges. The installation of these modules results in a distributed control with localised field cabling and hence better fault diagnosis. (author)

  1. Proposed dedicated high pressure beam lines at CHESS

    International Nuclear Information System (INIS)

    Ruoff, A.L.; Vohra, Y.K.; Bassett, W.A.; Batterman, B.W.; Bilderback, D.H.

    1988-01-01

    An instrumentation proposal for dedicated high pressure beam lines at CHESS is described. It is the purpose of this proposed program to provide researchers in high pressure science with beam lines for X-ray diffraction studies in the megabar regime. This will involve radiation from a bending magnet as well as from a wiggler. Examples of the high pressure results up to 2.16 Mbar are shown. Diffraction patterns from bending magnet and wiggler beams are shown and compared. The need for this facility by the high pressure community is discussed. (orig.)

  2. Development of slow positron beam lines and applications

    Science.gov (United States)

    Mondal, Nagendra Nath

    2018-05-01

    A positron is an antiparticle of an electron that can be formed in diverse methods: natural or artificial β-decay process, fission and fusion reactions, and a pair production of electron-positron occurred in the reactor and the high energy accelerator centers. Usually a long-lifetime radio isotope is customized for the construction of a slow positron beam lines in many laboratories. The typical intensity of this beam depends upon the strength of the positron source, moderator efficiency, and guiding, pulsing, focusing and detecting systems. This article will review a few positron beam lines and their potential applications in research, especially in the Positronium Bose-Einstein Condensation.

  3. Phase II beam lines at the National Synchrotron Light Source

    International Nuclear Information System (INIS)

    Thomlinson, W.

    1984-06-01

    The expansion of the National Synchrotron Light Source has been funded by the US Department of Energy. The Phase II program consists of both increased conventional facilities and six new beam lines. In this paper, an overview of the six beam lines which will be constructed during Phase II is presented. For five of the lines special radiation sources are necessary and the designs of four of the devices are complete. The relevant parameters of the insertion devices under construction and development are presented

  4. An alternative beam line at the U-400 M cyclotron for RIB separation and transport to the FOBOS spectrometer (The technical proposal)

    International Nuclear Information System (INIS)

    Majdikov, V.Z.; Bashevoj, V.V.

    1998-01-01

    The first order ion-optic calculations performed together with the graphical modeling permits us to propose a new variant of the beam-transport line from the backside of the U-400M cyclotron to the FOBOS spectrometer. This beam line could be built in a rather short time without large financial expenditures from available magnetic and vacuum elements. The new beam line could even be considered as an economic alternative to the existing beam line and as a RIB separator. This work is the result of the pre-design R and D aimed to develop the U-400M cyclotron facilities for the RIB experiments performance with the FOBOS spectrometer

  5. The EPICS-based remote control system for muon beam line devices at J-PARC MUSE

    Science.gov (United States)

    Ito, T. U.; Nakahara, K.; Kawase, M.; Fujimori, H.; Kobayashi, Y.; Higemoto, W.; Miyake, Y.

    2010-04-01

    The remote control system for muon beam line devices of J-PARC MUSE has been developed with the Experimental Physics and Industrial Control System (EPICS). The EPICS input/output controller was installed in standard Linux PCs for slow control of the devices. Power supplies for 21 magnetic elements and four slit controllers for the decay-surface muon beam line in the Materials and Life Science Experimental Facility are now accessible via Ethernet from a graphical user interface which has been composed using the Motif Editor and Display Manger.

  6. The new vertical neutron beam line at the CERN n-TOF facility design and outlook on the performance

    Energy Technology Data Exchange (ETDEWEB)

    Weiß, C., E-mail: christina.weiss@cern.ch [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Chiaveri, E.; Girod, S.; Vlachoudis, V.; Aberle, O. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Barros, S. [Instituto Tecnológico e Nuclear, Instituto Superior Técnico, Universidade Técnica de Lisboa, Lisboa (Portugal); Bergström, I. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Berthoumieux, E. [Commissariat à l’Énergie Atomique (CEA) Saclay – Irfu, Gif-sur-Yvette (France); Calviani, M. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Guerrero, C.; Sabaté-Gilarte, M. [Universidad de Sevilla (Spain); European Organization for Nuclear Research (CERN), Geneva (Switzerland); Tsinganis, A. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); National Technical University of Athens (NTUA) (Greece); Andrzejewski, J. [Uniwersytet Łódzki, Lodz (Poland); Audouin, L. [Centre National de la Recherche Scientifique/IN2P3 – IPN, Orsay (France); Bacak, M. [Atominstitut, Technische Universität Wien (Austria); Balibrea-Correa, J. [Centro de Investigaciones Energeticas Medioambientales y Tecnológicas (CIEMAT), Madrid (Spain); Barbagallo, M. [Istituto Nazionale di Fisica Nucleare, Bari (Italy); Bécares, V. [Centro de Investigaciones Energeticas Medioambientales y Tecnológicas (CIEMAT), Madrid (Spain); and others

    2015-11-01

    At the neutron time-of-flight facility n-TOF at CERN a new vertical beam line was constructed in 2014, in order to extend the experimental possibilities at this facility to an even wider range of challenging cross-section measurements of interest in astrophysics, nuclear technology and medical physics. The design of the beam line and the experimental hall was based on FLUKA Monte Carlo simulations, aiming at maximizing the neutron flux, reducing the beam halo and minimizing the background from neutrons interacting with the collimator or back-scattered in the beam dump. The present paper gives an overview on the design of the beam line and the relevant elements and provides an outlook on the expected performance regarding the neutron beam intensity, shape and energy resolution, as well as the neutron and photon backgrounds.

  7. Beam line design for a low energy electron beam

    International Nuclear Information System (INIS)

    Arvind Kumar; Mahadevan, S.

    2002-01-01

    The design of a beam line for transport of a 70 keV electron beam from a thermionic gun to the Plane Wave Transformer (PWT) linac incorporating two solenoid magnets, a beam profile monitor and drift sections is presented. We used beam dynamics codes EGUN, PARMELA and compare simulated results with analytical calculations. (author)

  8. Collider detector beam line test table: a structural analysis

    International Nuclear Information System (INIS)

    Leininger, M.B.

    1983-01-01

    The apparatus which sweeps calorimeter and endwall modules through the beam during testing is called a beam line test table. Because of rather stringent requirements for the physical positioning of the modules an analysis is done here to determine the modifications to the current test table design which will minimize deflections of the table under load

  9. Design and development of radiation absorber for sighting beam line

    International Nuclear Information System (INIS)

    Sridhar, R.; Shukla, S.K.

    2005-01-01

    During the commissioning of Indus-2 , it is necessary to view the synchrotron radiation that will be emanating from the dipole exit ports. The 10 0 beam line from dipole 11 was earmarked for sighting beam line. The synchrotron radiation power density would be around 340 watts on the photon absorber inside the radiation absorber module, at the specified beam power of Indus-2. The beam striking on this photon absorber produces x-rays and Bremsstrahlung radiation. These are to be stopped and absorbed by radiation absorber. The photon absorber and the radiation absorber are integrated in a single vacuum chamber and actuated by a pneumatic cylinder connected using a bellow. Radiation absorber was needed to isolate the diagnostic components and to protect them from radiation a well as heat when they were not in use. The paper describes the design, calculation and development of the dynamic photon cum radiation absorber. The ultimate vacuum performance is also described. (author)

  10. Beam line design for synchrotron spectroscopy in the VUV

    Energy Technology Data Exchange (ETDEWEB)

    Howells, M R

    1980-01-01

    The character of the radiation source provided by an electron storage ring is briefly reviewed from the point of view of utilization for VUV spectroscopy. The design of beam line components is then considered with special reference to the problems of contamination of optical surfaces and vacuum protection. The issues involved in designing mirrors for use with storage rings are considered with emphasis on the questions of power dissipation, image quality and materials selection.

  11. Beam line design for synchrotron spectroscopy in the VUV

    International Nuclear Information System (INIS)

    Howells, M.R.

    1980-01-01

    The character of the radiation source provided by an electron storage ring is briefly reviewed from the point of view of utilization for VUV spectroscopy. The design of beam line components is then considered with special reference to the problems of contamination of optical surfaces and vacuum protection. The issues involved in designing mirrors for use with storage rings are considered with emphasis on the questions of power dissipation, image quality and materials selection

  12. Construction of a pulsed MeV positron beam line

    Energy Technology Data Exchange (ETDEWEB)

    Masuno, Shin-ichi; Okada, Sohei; Kawasuso, Atsuo [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

    1997-03-01

    To develop a fast (1 MeV) and short pulsed (100 ps) positron beam which enables defect behavior analysis of bulk states of materials even at high temperatures where a usual positron source would melt, we have been performing design study and construction of the beam line in a three-year program since 1994. This report describes the components, design study results and experimental results of the completed parts until now. (author)

  13. Diagnostic tools used in the calibration and verification of protein crystallography synchrotron beam lines and apparatus

    International Nuclear Information System (INIS)

    Rotella, F.J.; Alkire, R.W.; Duke, N.E.C.; Molitsky, M.J.

    2011-01-01

    Diagnostic tools have been developed for use at the Structural Biology Center beam lines at the Advanced Photon Source. These tools are used in the calibration and operating verification of these synchrotron X-ray beam lines and constituent equipment.

  14. Design of Database System of HIRFL-CSR Beam Line

    International Nuclear Information System (INIS)

    Li Peng; Li Ke; Yin Dayu; Yuan Youjin; Gou Shizhe

    2009-01-01

    This paper introduces the database design and optimization for the power supply system of Lanzhou Heavy Ion Accelerator CSR (HIRFL-CSR) beam line. Based on HIFEL-CSR main Oracle database system, the interface was designed to read parameters of the power supply while achieving real-time monitoring. A new database system to store the history data of power supplies was established at the same time, and it realized the data exchange between Oracle database system and Access database system. Meanwhile, the interface was designed conveniently for printing and query parameters. (authors)

  15. The Imaging and Medical Beam Line at the Australian Synchrotron

    Science.gov (United States)

    Hausermann, Daniel; Hall, Chris; Maksimenko, Anton; Campbell, Colin

    2010-07-01

    As a result of the enthusiastic support from the Australian biomedical, medical and clinical communities, the Australian Synchrotron is constructing a world-class facility for medical research, the `Imaging and Medical Beamline'. The IMBL began phased commissioning in late 2008 and is scheduled to commence the first clinical research programs with patients in 2011. It will provide unrivalled x-ray facilities for imaging and radiotherapy for a wide range of research applications in diseases, treatments and understanding of physiological processes. The main clinical research drivers are currently high resolution and sensitivity cardiac and breast imaging, cell tracking applied to regenerative and stem cell medicine and cancer therapies. The beam line has a maximum source to sample distance of 136 m and will deliver a 60 cm by 4 cm x-ray beam1—monochromatic and white—to a three storey satellite building fully equipped for pre-clinical and clinical research. Currently operating with a 1.4 Tesla multi-pole wiggler, it will upgrade to a 4.2 Tesla device which requires the ability to handle up to 21 kW of x-ray power at any point along the beam line. The applications envisaged for this facility include imaging thick objects encompassing materials, humans and animals. Imaging can be performed in the range 15-150 keV. Radiotherapy research typically requires energies between 30 and 120 keV, for both monochromatic and broad beam.

  16. RFQ Cooler and Buncher (and beam line section associated)

    CERN Document Server

    Podadera-Aliseda, I

    2003-01-01

    Developing a new RFQ cooler and buncher for ISOLDE. Such a device combines an energy loss in buffer gas atom-ion collisions with confinement provided by RF-field in transverse plane. Optional confinement in longitudinal direction is provided by static potential dwell. Then, an improvement of the beam line is achieved for all the experiments at ISOLDE. The RFQ operates inside a high voltage cage of 60 kV, and with a system of turbomulecular pumps both to keep the high vacuum before/after the RFQ and to keep a low pressure (around 0,1 mbar) inside the RFQ. The project is to be thought not only as a mechanical design and construction project, unless as a project of research and development, since it is about improving (operationally and technically) the existing RFQ cooler and buncher placed around the world. Due to ion optical reasons whole beam line section has to be redesigned and constructed as a part of this project.

  17. Physics design of heavy-ion irradiation beam line on HI-13 tandem accelerator

    International Nuclear Information System (INIS)

    Zhu Fei; Peng Zhaohua; Hu Yueming; Jiao Xuesheng; Chen Dongfeng; Cao Yali

    2014-01-01

    Background: Heavy-ion microporous membrane is a new kind of filter material, which has prosperous application in the fields of medical and biological agents, electronic, food, environmental science, materials science, etc. Purpose: Polyester membranes were irradiated with 32 S produced by HI-13 tandem accelerator to develop a microporous membrane at CIAE, and the irradiation uniformity is determined by the beam distribution, also the microporous uniformity is required higher than 90%. Methods: An octupole magnet was used to correct the beam distribution from Gauss to uniform. Meanwhile, main parameters of beam line were given, and the alignment tolerances for optical elements were also analyzed. Results: Alignment tolerance of the optical elements could cause great influence on the beam center deviation in the process of correction, which would destroy the irradiation uniformity. Steering magnet was applied to meet with the design requirements. Conclusion: This study provides a practical and feasible way for industrial production of heavy-ion microporous membrane. (authors)

  18. Quantification of multiple elements in dried blood spot samples

    DEFF Research Database (Denmark)

    Pedersen, Lise; Andersen-Ranberg, Karen; Hollergaard, Mads

    2017-01-01

    BACKGROUND: Dried blood spots (DBS) is a unique matrix that offers advantages compared to conventional blood collection making it increasingly popular in large population studies. We here describe development and validation of a method to determine multiple elements in DBS. METHODS: Elements were...... in venous blood. Samples with different hematocrit were spotted onto filter paper to assess hematocrit effect. RESULTS: The established method was precise and accurate for measurement of most elements in DBS. There was a significant but relatively weak correlation between measurement of the elements Mg, K...

  19. Beam dynamics calculations for the linac booster beam line

    International Nuclear Information System (INIS)

    Lu, J.Q.; Cramer, J.G.; Storm, D.W.

    1987-01-01

    Beam optics focusing characteristics both in the transverse and longitudinal directions of the superconducting linac booster beam line are calculated for different particles. Three computer programs, which are TRANSPORT, LYRA and ENTIME, are used to simulate particle motions. The first one is used to simulate the particle radial motions. The effects of energy increase on to the transverse phase space area are considered by putting in accelerating matrices of each resonators. The second program is used to simulate particle longitudinal motions. Beam longitudinal motions are calculated with program ENTIME also, with which visual pictures in the Energy-Time phase space can be displayed on the terminal screen. Besides, the stability of the particle periodic motions in the radial directions are considered and calculated

  20. Secondary beam line phase space measurement and modeling at LAMPF

    International Nuclear Information System (INIS)

    Floyd, R.; Harrison, J.; Macek, R.; Sanders, G.

    1979-01-01

    Hardware and software have been developed for precision on-line measurement and fitting of secondary beam line phase space parameters. A system consisting of three MWPC planes for measuring particle trajectories, in coincidence with a time-of-flight telescope and a range telescope for particle identification, has been interfaced to a computer. Software has been developed for on-line track reconstruction, application of experimental cuts, and fitting of two-dimensional phase space ellipses for each particle species. The measured distributions have been found to agree well with the predictions of the Monte Carlo program DECAY TURTLE. The fitted phase space ellipses are a useful input to optimization routines, such as TRANSPORT, used to search for superior tunes. Application of this system to the LAMPF Stopped Muon Channel is described

  1. Grasshopper beam line for utilization of synchrotron radiation

    International Nuclear Information System (INIS)

    Saito, Norio; Suzuki, I.H.; Onuki, Hideo; Nishi, Morotake

    1989-01-01

    Optical characteristics of a new beam line consisting of a pre-mirror, a Grasshopper monochromator and a re-focusing mirror have been investigated. A ray-tracing calculation was performed for designing the mirrors so as to optimize the photon intensity and the spot size at the sample point. The intensity of the monochromatic soft x-ray was about 10 8 photons/(sec·100mA) at 25 A under the storage electron energy of 600 MeV with the minimum slit width which corresponded to a resolution of about 500. The sum of stray light and higher order components was less than 10% of the total intensity except around the C-K edge. Using an appropriate filter, it was reduced to less than a few percent. (author)

  2. Beam Line VI REC-steel hybrid wiggler for SSRL

    International Nuclear Information System (INIS)

    Hoyer, E.; Chan, T.; Chin, J.W.G.; Halbach, K.; Kim, K.J.; Winick, H.; Yang, J.

    1983-03-01

    A wiggler magnet with 27 periods, each 7 cm long which reaches 1.21 T at a 1.2 cm gap and 1.64 T at 0.8 cm gap has been designed and is in fabrication. Installation in SPEAR is scheduled for mid 1983. This new wiggler will be the radiation source for a new high intensity synchrotron radiation beam line at SSRL. The magnet utilizes rare-earth cobalt (REC) material and steel in a hybrid configuration to achieve simultaneously a high magnetic field with a short period. The magnet is external to a thin walled variable gap stainless steel vacuum chamber which is opened to provide beam aperture of 1.8 cm gap at injection and then closed to a smaller aperture (< 1.0 cm). Five independent drive systems are provided to adjust the magnet and chamber gaps and alignment. Magnetic design, construction details and magnetic measurements are presented

  3. Preliminary design of electrostatic sensors for MITICA beam line components

    Energy Technology Data Exchange (ETDEWEB)

    Spagnolo, S., E-mail: spagnolo@igi.cnr.it; Spolaore, M.; Dalla Palma, M.; Pasqualotto, R.; Sartori, E.; Serianni, G.; Veltri, P. [Consorzio RFX, Associazione EURATOM-ENEA sulla Fusione, 35127 Padova (Italy)

    2016-02-15

    Megavolt ITER Injector and Concept Advancement, the full-scale prototype of ITER neutral beam injector, is under construction in Italy. The device will generate deuterium negative ions, then accelerated and neutralized. The emerging beam, after removal of residual ions, will be dumped onto a calorimeter. The presence of plasma and its parameters will be monitored in the components of the beam-line, by means of specific electrostatic probes. Double probes, with the possibility to be configured as Langmuir probes and provide local ion density and electron temperature measurements, will be employed in the neutralizer and in the residual ion dump. Biased electrodes collecting secondary emission electrons will be installed in the calorimeter with the aim to provide a horizontal profile of the beam.

  4. CONTINOUS EXTRACTED BEAM IN THE AGS FAST EXTERNAL BEAM LINE

    International Nuclear Information System (INIS)

    GLENN, J.W.; TSOUPAS, N.; BROWN, K.A.; BIRYUKOV, V.M.

    2001-01-01

    A method to split off a few percent of the 6 x 10 13 AGS beam delivered to the Slow External Beam (SEB) lines and send it down the Fast External Beam line (FEB) has been developed. The mission is to feed a counter experiment off the FEB that directly measures the neutrino mass using the muon storage ring. The use of normal thin septum splitters would have an excessive loss overhead and been optically difficult. The AGS Slow Extraction uses a third integer resonance with sextuple strength so the resonance width is a few percent of the beam width. This results in a low density tail which will be clipped by a bent crystal and deflected into the FEB channel. This clipping off of the tail should reduce losses in the SEB transport line. Details of modeled orbits, particle distribution and extraction trajectories into and out off the crystal will be given

  5. Optical and mechanical design of the extended x-ray absorption fine structure (EXAFS) beam-line at Indus-II synchrotron source

    International Nuclear Information System (INIS)

    Das, N.C.; Jha, S.N.; Bhattacharyya, D.; Sinha, A.K.; Mishra, V.K.; Verma, Vishnu; Ghosh, A.K.

    2002-11-01

    An extended x-ray absorption fine structure (EXAFS) beam line for x-ray absorption studies using energy dispersive geometry and position sensitive detector is being designed for the INDUS-II Synchrotron source. The beam line would be used for doing x-ray absorption experiments involving measurements of fme structures above the absorption edge of different species of atoms in a material The results of the above experiments would lead to the determination of different important structural parameters of materials viz.. inter-atomic distance. co-ordination number, degree of disorder and radial distribution function etc. The optical design of the beam line has been completed based on the working principle that a single crystal bent in the shape of an ellipse by a crystal bender would act as a dispersing as well as focusing element. The mechanical design of the beam line including the crystal bender has also been completed and discussed here. Calculations have been done to detennine the temperature profile on the different components of the beam line under exposure to synchrotron radiation and proper cooling channels have been designed to bring down the heat load on the components. (author)

  6. Neutron beam-line shield design for the protein crystallography instrument at the Lujan Center

    International Nuclear Information System (INIS)

    Russell, G.J.; Pitcher, E.J.; Muhrer, G.; Ferguson, P.D.

    2001-01-01

    We have developed a very useful methodology for calculating absolute total (neutron plus gamma-ray) dose equivalent rates for use in the design of neutron beam line shields at a spallation neutron source. We have applied this technique to the design of beam line shields for several new materials science instruments being built at the Manuel Lujan Jr. Neutron Scattering Center. These instruments have a variety of collimation systems and different beam line shielding issues. We show here some specific beam line shield designs for the Protein Crystallography Instrument. (author)

  7. Requirements and guidelines for NSLS experimental beam line vacuum systems: Revision A

    International Nuclear Information System (INIS)

    Foerster, C.; Halama, H.; Thomlinson, W.

    1986-10-01

    Requirements are provided for NSLS beam line front ends and vacuum interlocks. Guidelines are provided for UHV beam line vacuum systems, including materials, vacuum hardware (pumps, valves, and flanges), acoustic delay lines and beam line fast valves, instrumentation, fabrication and testing, and the NSLS cleaning facility. Also discussed are the design review for experimenters' equipment that would be connected to the NSLS and acceptance tests for any beam line to be connected with the ring vacuum. Also appended are a description of the acoustic delay line as well as the NSLS vacuum standards and NSLS procedures

  8. Target and orbit feedback simulations of a muSR beam line at BNL

    Energy Technology Data Exchange (ETDEWEB)

    MacKay, W. [Brookhaven National Lab. (BNL), Upton, NY (United States); Blaskiewicz, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Fischer, W. [Brookhaven National Lab. (BNL), Upton, NY (United States); Pile, P. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-07-28

    Well-polarized positive surface muons are a tool to measure the magnetic properties of materials since the precession rate of the spin can be determined from the observation of the positron directions when the muons decay. For a dc beam an ideal µSR flux for surface µ+ should be about 40 kHz/mm2. In this report we show how this flux could be achieved in a beam line using the AGS complex at BNL for a source of protons. We also determined that an orbit feedback system with a pair of thin silicon position monitors and kickers would miss the desired flux by at least an order of magnitude, even with perfect time resolution and no multiple scattering.

  9. Report of the accelerator and beam line options working group

    International Nuclear Information System (INIS)

    Ankenbrandt, C.; Bogacz, A.; Bogert, D.; Bossert, R.C.; Brown, B.; Childress, S.; Crawford, C.; Dugan, G.; Even, L.; Finley, D.; Gelfand, N.; Gerig, R.; Goderre, G.; Gourlay, S.; Griffin, J.; Hahn, A.; Holmes, S.; Jackson, G.; Johnson, R.; Johnson, D.; Kerby, J.; Koepke, K.; Koizumi, G.; Koul, R.; Lamm, M.; MacLachlan, J.; Malamud, E.; Malensek, A.; Mantsch, P.; Marriner, J.; Marsh, B.; Martin, P.; Hills, F.; Moore, C.; Murphy, T.; Nicol, T.; Peterson, T.; Pruss, S.; Rameika, G.; Riddiford, A.; Rosenzweig, J.; Russell, A.; Saritepe, S.; Stahl, S.; Strait, J.; Trbojevic, D.; Visnjic, V.; Volk, J.; Johnson, D.; Syphers, M.; Mohl, D.; Ruggiero, S.; Collins, T.

    1990-01-01

    This report summarizes work done before, during, and after the conference. The group was broken down into six subgroups. Subgroup 1 considered collider aspects of the phase 1 and phase 2 upgrade plans. Also considered were the collider aspects of a specific example of Phase 3, namely the replacement of the Tevatron with a new ring providing 1.8 TeV per beam. Subgroup 2 considered specific improvements to the proposed Main Injector (MI) which will enhance the performance of Phase 2. Also considered were improvements which may be made to the present Main Ring (MR) which will enchance performance of Phase 1. Subgroup 3 considered fixed target aspects of the Phase 1 and 2 upgrade plans and a specific example of Phase 3, namely the replacement of the Tevatron with a new ring providing 1.5 TeV fixed target operation. Subgroup 4 considered the external beam lines associated with the upgrades. Subgroup 5 considered the new designs of the superconducting magnets and associated large cryogenic systems connected with the accelerator systems proposed by the other groups. Subgroup 6 assumed the existence of Phase 1 and 2 upgrades and considered new possibilities for Phase 3 such as new accelerators in new tunnels

  10. Computer controlled vacuum control system for synchrotron radiation beam lines

    International Nuclear Information System (INIS)

    Goldberg, S.M.; Wang, C.; Yang, J.

    1983-01-01

    The increasing number and complexity of vacuum control systems at the Stanford Synchrotron Radiation Laboratory has resulted in the need to computerize its operations in order to lower costs and increase efficiency of operation. Status signals are transmitted through digital and analog serial data links which use microprocessors to monitor vacuum status continuously. Each microprocessor has a unique address and up to 256 can be connected to the host computer over a single RS232 data line. A FORTRAN program on the host computer will request status messages and send control messages via only one RS232 line per beam line, signal the operator when a fault condition occurs, take automatic corrective actions, warn of impending valve failure, and keep a running log of all changes in vacuum status for later recall. Wiring costs are thus greatly reduced and more status conditions can be monitored without adding excessively to the complexity of the system. Operators can then obtain status reports at various locations in the lab quickly without having to read a large number of meter and LED's

  11. MIRKO - An interactive program for beam lines and synchrotrons

    International Nuclear Information System (INIS)

    Franczak, B.

    1984-01-01

    The ion-optical design of beam lines and synchrotrons is usually not done by a single run of one program. It takes many iterations of calculation, examination of results, and modification of input data. In most cases the first order design has to be followed by the investigation of higher order effects, i.e. chromatic and geometrical aberrations or resonance phenomena. The interactive computer program MIRKO is operated from a terminal and has a command structure, which enables the user to edit data, perform calculations, and to obtain alpha or graphics output on the terminal in any desired sequence. With graphics one can recognize the properties of an optical system much faster than with numbers only. Thus modifications of input data depending on the results of calculations can be made easily without stopping and restarting the program. Higher order effects can sometimes influence the first order design. Therefore, particle tracking capability was included in MIRKO as well as the calculation of stop band widths for synchrotrons. Consequently a large variety of phenomena can be studied with one program in one session based upon exactly the same data for the optical system and the possibility of fast switching between the different features

  12. Cryogenic supplies for the TFTR neutral beam line cryopanels

    International Nuclear Information System (INIS)

    Pinter, G.

    1977-01-01

    Cryocondensing panels will be used for the Neutral Beam Lines of the TFTR to satisfy a pumping speed requirement of 2.5 x 10 6 l/s. The cryocondensing panels are fed by liquid helium (LHe), boiling at selectable temperatures of 4.5 0 K or 3.8 0 K. Liquid nitrogen (LN 2 ) panels and chevrons thermally shield the LHe panel. The closed-loop LHe supply system and the open loop LN 2 system are discussed. The helium refrigerator of minimum 1070-W capacity, together with its distribution system, and the nitrogen distribution system in the ton/hour LN 2 range is presented. Problems and their solutions in connection with the LHe system, including the distribution over a distance of 500 feet of large quantities of liquid/gas mixtures with load variations over the range of about 3 : 1, and the economies of various types of distribution lines (passive, pumped, shielded, combined), are described. The system design passed the preliminary phase. Design features and auxiliary equipment to assure dispersion of large quantities of nitrogen into the atmosphere and to permit operation under degraded cryogenic helium refrigerator performance are also discussed in Design Considerations

  13. Development of highly polished, grazing incidence mirrors for synchrotron radiation beam lines at SSRL

    Energy Technology Data Exchange (ETDEWEB)

    Tirsell, K.G.; Berglin, E.J.; Fuchs, B.A.; Holdener, F.R.; Humpal, H.H.; Karpenko, V.P.; Kulkarni, S.; Fantone, S.D.

    1987-08-01

    New platinum-coated grazing incidence mirrors with low surface roughnesses have been developed to focus bending magnet radiation from the SSRL/SLAC SPEAR storage ring on the entrance slits of two Beam Line VIII grating monochromators. The first mirror in the toroidal grating monochromator (TGM) branch is a cooled SiC cylinder capable of absorbing synchrotron radiation power levels of up to 260 watts without excessive distortion. This mirror deflects the beam vertically through a 12/degree/ angle and focuses it sagitally on the TGM entrance slit plane. The second TGM optical element is a fused-silica spherical mirror with a large radius of curvature that deflects the beam vertically through an additional 12/degree/ and focuses it tangentially with 3/1 demagnification. The first mirror in our spherical grating branch is a 5/degree/-vertically deflecting, cooled SiC toroid designed to focus tangentially on the monochromator entrance slits and sagitally in the exit slits. A 4/degree/-deflecting fused silica mirror is used after the exit sites in each beam line to refocus on to the sample. For this application a thin cylinder is bent to approximate an ellipsoid. The mirrors are now installed at SSRL and performance measurements are planned. Qualitatively the focus of the TGM optics at the entrance slit plane appears very good. In this paper we discuss considerations leading to the choice of SiC for each of the two first mirrors. We present highlights of the development of these mirrors with some emphasis on SiC polishing techniques. In addition, the specialized metrology developed to produce the more difficult figure of the toroid will be described. Measured surface roughness and figure results will be presented. 19 refs., 11 figs.

  14. Development of highly polished, grazing incidence mirrors for synchrotron radiation beam lines at SSRL

    International Nuclear Information System (INIS)

    Tirsell, K.G.; Berglin, E.J.; Fuchs, B.A.; Holdener, F.R.; Humpal, H.H.; Karpenko, V.P.; Kulkarni, S.; Fantone, S.D.

    1987-08-01

    New platinum-coated grazing incidence mirrors with low surface roughnesses have been developed to focus bending magnet radiation from the SSRL/SLAC SPEAR storage ring on the entrance slits of two Beam Line VIII grating monochromators. The first mirror in the toroidal grating monochromator (TGM) branch is a cooled SiC cylinder capable of absorbing synchrotron radiation power levels of up to 260 watts without excessive distortion. This mirror deflects the beam vertically through a 12/degree/ angle and focuses it sagitally on the TGM entrance slit plane. The second TGM optical element is a fused-silica spherical mirror with a large radius of curvature that deflects the beam vertically through an additional 12/degree/ and focuses it tangentially with 3/1 demagnification. The first mirror in our spherical grating branch is a 5/degree/-vertically deflecting, cooled SiC toroid designed to focus tangentially on the monochromator entrance slits and sagitally in the exit slits. A 4/degree/-deflecting fused silica mirror is used after the exit sites in each beam line to refocus on to the sample. For this application a thin cylinder is bent to approximate an ellipsoid. The mirrors are now installed at SSRL and performance measurements are planned. Qualitatively the focus of the TGM optics at the entrance slit plane appears very good. In this paper we discuss considerations leading to the choice of SiC for each of the two first mirrors. We present highlights of the development of these mirrors with some emphasis on SiC polishing techniques. In addition, the specialized metrology developed to produce the more difficult figure of the toroid will be described. Measured surface roughness and figure results will be presented. 19 refs., 11 figs

  15. Construction of Superconducting Magnet System for the J-PARC Neutrino Beam Line

    Energy Technology Data Exchange (ETDEWEB)

    Nakamoto, T.; Wanderer, P.; Sasaki, K.; Ajima, Y.; Araoka, O.; Fujii, Y.; Hastings, N.; Higashi, N.; Iida, M.; Ishii, T.; Kimura, N.; Kobayashi, T.; Makida, Y.; Nakadaira, T.; Ogitsu, T.; Ohhata, H.; Okamura, T.; Sakashita, K.; Sugawara, S.; Suzuki, S.; Tanaka, K.; Tomaru, T.; Terashima, A.; Yamamoto, A.; Ichikawa, A.; Kakuno, H.; Anerella, M.; Escallier, J.; Ganetis, G.; gupta, R.; Jain, A.; Muratore, J.; Parker, B.; Boussuge, T.; Charrier, J.-P.; Arakawa, M.; Ichihara, T.; Minato, T.; Okada, Y.; Itou, A.; Kumaki, T.; Nagami, M.; Takahashi, T.

    2009-10-18

    Following success of a prototype R&D, construction of a superconducting magnet system for J-PARC neutrino beam line has been carried out since 2005. A new conceptual beam line with the superconducting combined function magnets demonstrated the successful beam transport to the neutrino production target.

  16. SLC beam line error analysis using a model-based expert system

    International Nuclear Information System (INIS)

    Lee, M.; Kleban, S.

    1988-02-01

    Commissioning particle beam line is usually a very time-consuming and labor-intensive task for accelerator physicists. To aid in commissioning, we developed a model-based expert system that identifies error-free regions, as well as localizing beam line errors. This paper will give examples of the use of our system for the SLC commissioning. 8 refs., 5 figs

  17. Operating instructions for ORELA [Oak Ridge Electron Linear Accelerator] positron beam line

    International Nuclear Information System (INIS)

    Donohue, D.L.; Hulett, L.D. Jr.; Lewis, T.A.

    1990-11-01

    This report will contain details of the construction and operation of the positron beam line. Special procedures which are performed on a less frequent basis will also be described. Appendices will contain operating instructions for experiments which make use of the positron beam and are connected to the beam line. Finally, a review of safety-related considerations will be presented

  18. Reliability analysis of minimum energy on target for laser facilities with more beam lines

    International Nuclear Information System (INIS)

    Chen Guangyu

    2008-01-01

    Shot reliability performance measures of laser facilities with more beam lines pertain to three categories: minimum-energy-on-target, power balance, and shot diagnostics. Accounting for symmetry of NIF beam line design and similarity of subset reliability in a same partition, a fault tree of meeting minimum-energy-on-target for the large laser facility shot of type K and a simplified method are presented, which are used to analyze hypothetic reliability of partition subsets in order to get trends of influences increasing number of beam lines and diverse shot types of large laser facilities on their shot reliability. Finally, it finds that improving component reliability is more crucial for laser facilities with more beam lines in comparison with those with beam lines and functional diversity from design flexibility is greatly helpful for improving shot reliability. (authors)

  19. NSLS infra-red beam line (U3) conceptual design report

    Energy Technology Data Exchange (ETDEWEB)

    Williams, G.P.

    1984-02-09

    We describe the conceptual design of an infrared (I-R) beam line on the vacuum-ultra-violet storage ring of the National Synchrotron Light Source. The beam line forms part of the Phase II expansion of the NSLS. Consistent with the implementation of the current design is the extraction of hitherto wasted radiation and the establishment of a mezzanine floor or platform to make full use of the available headroom. This means that the I-R beam line, once established, does not interfere with any existing operations on the VUV floor.

  20. Developing an expert system to control a beam line at the Los Alamos Meson Physics Facility

    International Nuclear Information System (INIS)

    Clearwater, S.H.; Papcun, G.; Clark, D.A.

    1985-01-01

    High energy particle experiments require an accelerator as a source of high energy particles. To increase the productivity of an accelerator facility, we wish to develop an expert system to control beam lines. Expert Systems are a branch of Artificial Intelligence where a computer program performs tasks requiring human expertise. Unlike most expert systems we have a physical model underlying our beam line and this model can be used with the expert system to improve performance. The development of the expert system will lead to an increased understanding of the beam line as well as the possibility of state-of-the-art expert system building

  1. Workshop on a project for a FZR-beam line at ESRF

    International Nuclear Information System (INIS)

    Matz, W.

    1993-10-01

    The Research Center Rossendorf (FZR) investigates the possibilities to install its own beam line as a Cooperate Research Group-project (CRG) at the European Synchrotron Radiation Facility (ESRF) in Grenoble. The main interests for the FZR to use high brillant synchrotron radiation are in the Institute of Radiochemistry and the Institute of Ion Beam Physics and Materials Research. This workshop was organized by these two institutes together with the FZR Study group Synchrotron. The purpose of the workshop was to achieve a better understanding for the technical needs of the projected beam line for the planned research projects. Experts with experience in beam line design met with the Rossendorf groups to discuss the best layout for such a beam line. The summary of this workshop and the copies of transparencies of the lectures that were given are published in this booklet. (orig.)

  2. Evaluation of beam-line components for use in a large neutral-beam injector

    International Nuclear Information System (INIS)

    Fink, J.H.

    1977-01-01

    A conceptual model of a neutral-beam injector was used to examine the effect of beam-line components on reactor performance. Criteria were established to optimize a reactor's reliability and minimize its cost

  3. Experimental Program for the CLIC test facility 3 test beam line

    CERN Document Server

    Adli, E; Dobert, S; Olvegaard, M; Schulte, D; Syratchev, I; Lillestol, Reidar

    2010-01-01

    The CLIC Test Facility 3 Test Beam Line is the first prototype for the CLIC drive beam decelerator. Stable transport of the drive beam under deceleration is a mandatory component in the CLIC two-beam scheme. In the Test Beam Line more than 50% of the total energy will be extracted from a 150 MeV, 28 A electron drive beam, by the use of 16 power extraction and transfer structures. A number of experiments are foreseen to investigate the drive beam characteristics under deceleration in the Test Beam Line, including beam stability, beam blow up and the efficiency of the power extraction. General benchmarking of decelerator simulation and theory studies will also be performed. Specially designed instrumentation including precision BPMs, loss monitors and a time-resolved spectrometer dump will be used for the experiments. This paper describes the experimental program foreseen for the Test Beam Line, including the relevance of the results for the CLIC decelerator studies.

  4. Final design of the neutral beam lines for the Tokamak Fusion Test Reactor

    International Nuclear Information System (INIS)

    Pittenger, L.C.; Valby, L.E.; Stone, R.R.; Pedrotti, L.R.; Denhoy, B.; Yoard, R.

    1979-01-01

    Final design of the neutral beam lines for TFTR has been completed. A prototype has been assembled at Lawrence Berkeley Laboratory and is undergoing testing as part of the Neutral Beam System Test Facility (NBSTF). The final neutral beam line (NBL) configuration differs in several details from that previously reported upon; certain components have been added; and testing of the cryopump system has led to some design simplification. It is these developments which are reported herein

  5. Development of BPM/BLM DAQ System for KOMAC Beam Line

    Energy Technology Data Exchange (ETDEWEB)

    Song, Young-Gi; Kim, Jae-Ha; Yun, Sang-Pil; Kim, Han-Sung; Kwon, Hyeok-Jung; Cho, Yong-Sub [Korea Atomic Energy Research Institute, Gyeongju (Korea, Republic of)

    2016-10-15

    The proton beam is accelerated from 3 MeV to 100 MeV through 11 DTL tanks. The KOMAC installed 10 beam lines, 5 for 20-MeV beams and 5 for 100-MeV beams. The proton beam is transmitted to two target room. The KOMAC has been operating two beam lines, one for 20 MeV and one for 100 MeV. New beam line, RI beam line is under commissioning. A Data Acquisition (DAQ) system is essential to monitor beam signals in an analog front-end circuitry from BPM and BLM at beam lines. A data acquisition (DAQ) system is essential to monitor beam signals in an analog front-end circuitry from BPM and BLM at beam lines. The DAQ digitizes beam signal and the sampling is synchronized with a reference signal which is an external trigger for beam operation. The digitized data is accessible by the Experimental Physics and Industrial Control System (EPICS)-based control system, which manages the whole accelerator control. The beam monitoring system integrates BLM and BPM signals into the control system and offers realtime data to operators. The IOC, which is implemented with Linux and a PCI driver, supports data acquisition as a very flexible solution.

  6. Multiple-Zone Diffractive Optic Element for Laser Ranging Applications

    Science.gov (United States)

    Ramos-Izquierdo, Luis A.

    2011-01-01

    A diffractive optic element (DOE) can be used as a beam splitter to generate multiple laser beams from a single input laser beam. This technology has been recently used in LRO s Lunar Orbiter Laser Altimeter (LOLA) instrument to generate five laser beams that measure the lunar topography from a 50-km nominal mapping orbit (see figure). An extension of this approach is to use a multiple-zone DOE to allow a laser altimeter instrument to operate over a wider range of distances. In particular, a multiple-zone DOE could be used for applications that require both mapping and landing on a planetary body. In this case, the laser altimeter operating range would need to extend from several hundred kilometers down to a few meters. The innovator was recently involved in an investigation how to modify the LOLA instrument for the OSIRIS asteroid mapping and sample return mission. One approach is to replace the DOE in the LOLA laser beam expander assembly with a multiple-zone DOE that would allow for the simultaneous illumination of the asteroid with mapping and landing laser beams. The proposed OSIRIS multiple-zone DOE would generate the same LOLA five-beam output pattern for high-altitude topographic mapping, but would simultaneously generate a wide divergence angle beam using a small portion of the total laser energy for the approach and landing portion of the mission. Only a few percent of the total laser energy is required for approach and landing operations as the return signal increases as the inverse square of the ranging height. A wide divergence beam could be implemented by making the center of the DOE a diffractive or refractive negative lens. The beam energy and beam divergence characteristics of a multiple-zone DOE could be easily tailored to meet the requirements of other missions that require laser ranging data. Current single-zone DOE lithographic manufacturing techniques could also be used to fabricate a multiple-zone DOE by masking the different DOE zones during

  7. Global multiplicity of dietary standards for trace elements.

    Science.gov (United States)

    Freeland-Graves, Jeanne H; Lee, Jane J

    2012-06-01

    Consistent guidelines across the world for dietary standards of trace elements remain elusive. Harmonization of dietary standards has been suggested by international agencies to facilitate consistency in food and nutrition policies and international trade. Yet significant barriers exist to standardize recommendations on a global basis, such as vast differences in geography, food availability and transport; cultural, social and economic constraints, and biological diversity. Simple commonality is precluded further by the variety of terminologies among countries and regions related to diet. Certain unions have created numerous nutritional descriptive categories for standards, while other large countries are limited to only a few. This paper will explore the global multiplicity of dietary standards and efforts for harmonization. Copyright © 2012 Elsevier GmbH. All rights reserved.

  8. Multiple single-element transducer photoacoustic computed tomography system

    Science.gov (United States)

    Kalva, Sandeep Kumar; Hui, Zhe Zhi; Pramanik, Manojit

    2018-02-01

    Light absorption by the chromophores (hemoglobin, melanin, water etc.) present in any biological tissue results in local temperature rise. This rise in temperature results in generation of pressure waves due to the thermoelastic expansion of the tissue. In a circular scanning photoacoustic computed tomography (PACT) system, these pressure waves can be detected using a single-element ultrasound transducer (SUST) (while rotating in full 360° around the sample) or using a circular array transducer. SUST takes several minutes to acquire the PA data around the sample whereas the circular array transducer takes only a fraction of seconds. Hence, for real time imaging circular array transducers are preferred. However, these circular array transducers are custom made, expensive and not easily available in the market whereas SUSTs are cheap and readily available in the market. Using SUST for PACT systems is still cost effective. In order to reduce the scanning time to few seconds instead of using single SUST (rotating 360° ), multiple SUSTs can be used at the same time to acquire the PA data. This will reduce the scanning time by two-fold in case of two SUSTs (rotating 180° ) or by four-fold and eight-fold in case of four SUSTs (rotating 90° ) and eight SUSTs (rotating 45° ) respectively. Here we show that with multiple SUSTs, similar PA images (numerical and experimental phantom data) can be obtained as that of PA images obtained using single SUST.

  9. An interactive beam line simulator module for RHIC

    International Nuclear Information System (INIS)

    MacKay, W.W.

    1997-01-01

    This paper describes the interactive simulation engine, bl, designed for the RHIC project. The program tracks as output to shared memory the central orbit, Twiss and dispersion functions, as well as the 6 x 6 beam hyperellipsoid. Transfer matrices between elements are available via interactive requests. Using a 6-d model, optical elements are modeled with a linear transfer matrix and a vector. The vector allows simulation of misalignments, shifts in field strengths, and beam rigidity. Currently only a linear model is used for elements. In addition to the usual magnets, a foil element is included which can shift the beam's rigidity (resulting from a change of charge and energy loss), as well as increase the momentum spread and emittance. Running as a Glish client, bl can be interfaced to other programs, such as an orbit plotter and a power supply application to give a quick prediction of the beam orbit from actual operating currents in the accelerator. Various strengths and offsets may be changed by sending Glish events to bl

  10. DOE/DMS workshop on future synchrotron VUV and x-ray beam Lines

    International Nuclear Information System (INIS)

    Green, P.H.

    1992-03-01

    This document contains an overview of the participating DOE Laboratory beam line interests and the projected science to be addressed on these beam lines, both at new and existing synchrotron facilities. The scientific programs associated with present and planned synchrotron research by DOE Laboratories are discussed in chapters titled ''VUV and Soft X-Ray Research'' and ''Hard X-Ray Research.'' This research encompasses a broad range of the nation's scientific and technical research needs from fundamental to applied, in areas including environmental, biological, and physical sciences; new materials; and energy-related technologies. The projected cost of this proposed construction has been provided in tabular form using a uniform format so that anticipated DOE and outside funding agency contributions for construction and for research and development can be determined. The cost figures are, of course, subject to uncertainties of detailed design requirements and the availability of facility-designed generic components and outside vendors. The report also contains a compendium (as submitted by the beam line proposers) of the design capabilities, the anticipated costs, and the scientific programs of projected beam line construction at the four synchrotron facilities. A summary of the projected cost of these beam lines to be requested of DOE is compiled

  11. Faraday cup: absolute dosimetry for ELIMED beam line

    International Nuclear Information System (INIS)

    Leanza, R.; Romano, F.; Scuderi, V.; Amico, A.G.; Cuttone, G.; Larosa, G.; Milluzzo, G.; Petringa, G.; Pipek, J.; Cirrone, G.A.P.; Margarone, D.; Schillaci, F.

    2017-01-01

    The scientific community has shown a growing interest towards multidisciplinary applications of laser-driven beams. In this framework, the ELIMED (ELI-Beamlines MEDical and multidisciplinary applications) beamline will be the first transport beamline dedicated to the medical and multidisciplinary studies with laser-accelerated ion beams. Detectors for dosimetry represent one of key-element of the ELIMED beamline, allowing a dose delivering with good result as required in the clinical applications. In this contribution, a Faraday Cup for absolute dosimetry, designed and realized at INFN-LNS, is described.

  12. Materials research and beam line operation utilizing NSLS [National Synchrotron Light Source]: Progress report

    International Nuclear Information System (INIS)

    Liedl, G.L.

    1987-10-01

    MATRIX is a group of scientists who have common interests in utilizing x-ray synchrotron radiation for materials research. This group has developed a specialized beam line (X-18A) for x-ray scattering studies at the National Synchrotron Light Source (NSLS). The beam line was designed to optimize experimental conditions for diffuse scattering and surface/interface studies. An extension of diffuse scattering to provide better quantitative data has been shown as well as a unique application to the solution of the phase problem. In the x-ray surface scattering area the first reported experiment to illustrate the capabilities for studying monolayers on water was performed. Current beam line upgrade projects are also described. In addition to a change to a UHV system and improvements dictated by operational experience, two new systems are described, a unique small angle scattering chamber (SAXS) for dynamic studies of nucleation and growth and a surface scattering chamber. 5 figs

  13. Transport and dosimetric solutions for the ELIMED laser-driven beam line

    Energy Technology Data Exchange (ETDEWEB)

    Cirrone, G.A.P. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Romano, F. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Medical Physics School, University of Catania, Via S. Sofia 64 - 95125 Catania (Italy); Scuderi, V. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Institute of Physics ASCR, v.v.i. (FZU), ELI-Beamlines Project, Na Slovance 2, 182 21 Prague (Czech Republic); Amato, A. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Candiano, G. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Medical Physics School, University of Catania, Via S. Sofia 64 - 95125 Catania (Italy); Cuttone, G. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Giove, D. [INFN Sezione di Milano, Via Celoria 16, Milano (Italy); Korn, G.; Krasa, J. [Institute of Physics ASCR, v.v.i. (FZU), ELI-Beamlines Project, Na Slovance 2, 182 21 Prague (Czech Republic); Leanza, R. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Universitá degli Studi di Catania, Dipartimento di Fisica e Astronomia, Via S. Sofia 64, Catania (Italy); Manna, R. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Maggiore, M. [INFN-LNL, Viale dell' Universitá 2 - 35020 Legnaro (PD) (Italy); Marchese, V. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Margarone, D. [Institute of Physics ASCR, v.v.i. (FZU), ELI-Beamlines Project, Na Slovance 2, 182 21 Prague (Czech Republic); Milluzzo, G. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Universitá degli Studi di Catania, Dipartimento di Fisica e Astronomia, Via S. Sofia 64, Catania (Italy); Petringa, G. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Sabini, M.G. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Azienda Ospedaliera Cannizzaro, Via Messina 829 - 95100 Catania (Italy); Schillaci, F. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Medical Physics School, University of Catania, Via S. Sofia 64 - 95125 Catania (Italy); and others

    2015-10-01

    Within 2017, the ELIMED (ELI-Beamlines MEDical applications) transport beam-line and dosimetric systems for laser-generated beams will be installed at the ELI-Beamlines facility in Prague (CZ), inside the ELIMAIA (ELI Multidisciplinary Applications of laser–Ion Acceleration) interaction room. The beam-line will be composed of two sections: one in vacuum, devoted to the collecting, focusing and energy selection of the primary beam and the second in air, where the ELIMED beam-line dosimetric devices will be located. This paper briefly describes the transport solutions that will be adopted together with the main dosimetric approaches. In particular, the description of an innovative Faraday Cup detector with its preliminary experimental tests will be reported.

  14. Muon Beam Studies in the H4 beam line and the Gamma Irradiation Facility (GIF++)

    CERN Document Server

    Margraf, Rachel; CERN. Geneva. EN Department

    2017-01-01

    In this report, I summarize my work of detailed study and optimization of the muon beam configuration of H4 beam line in SPS North Area. Using Monte-Carlo simulations, I studied the properties and behavior of the muon beam in combination with the field of the large, spectrometer “ GOLIATH” magnet at -1.5, -1.0, 0, 1.0 and 1.5 Tesla, which is shown to affect the central x position of the muon beam that is delivered to the Gamma Irradiation Facility (GIF++). I also studied the muon beam for different configurations of the two XTDV beam dumps upstream of GIF++ in the H4 beam line. I will also discuss my role in mapping the magnetic field of the GOLIATH magnet in the H4 beam line.

  15. A beam position feedback system for beam lines at the photon factory

    International Nuclear Information System (INIS)

    Katsura, T.; Kamiya, Y.; Haga, K.; Mitsuhashi, T.

    1987-01-01

    The beam position of the synchrotron radiation produced from the Storage Ring was stabilized by a twofold position feedback system. A digital feedback system was developed to suppress the diurnal beam movement (one cycle of sin-like drifting motion per day) which became a serious problem in low-emittance operation. The feedback was applied to the closed-orbit-distortion (COD) correction system in order to cancel the position variation at all the beam lines proportionately to the variation monitored at one beam line. An analog feedback system is also used to suppress frequency components faster than the slow diurnal movement

  16. The Joint Structural Biology Group beam lines at the ESRF: Modern macromolecular crystallography

    CERN Document Server

    Mitchell, E P

    2001-01-01

    Macromolecular crystallography has evolved considerably over the last decade. Data sets in under an hour are now possible on high throughput beam lines leading to electron density and, possibly, initial models calculated on-site. There are five beam lines currently dedicated to macromolecular crystallography: the ID14 complex and BM-14 (soon to be superseded by ID-29). These lines handle over five hundred projects every six months and demand is increasing. Automated sample handling, alignment and data management protocols will be required to work efficiently with this demanding load. Projects developing these themes are underway within the JSBG.

  17. Conceptual design report for the UNI-CAT beam line proposal

    International Nuclear Information System (INIS)

    Budai, J.D.; Ice, G.E.; Sparks, C.J.; Zschack, P.; Chen, H.; Chiang, T.C.; Nelson, M.C.; Salamon, M.B.; Simmons, R.O.; Robota, H.

    1992-08-01

    The overall thrusts of UNI-CAT (University-National Laboratory- Industry Collaborative Access Team) are research at the cutting edge of physics, chemistry, biology, materials science, chemical engineering, polymer science, and geology; and education of a new generation of scientists in the use of synchrotron radiation to probe the structure, chemistry, and dynamic behavior of materials. The UNI-CAT proposal is to develop an APS sector that includes a bending magnet beam line and an insertion device beam line. The APS type-A undulator is the preferred choice for the insertion device. 8 figs, 6 refs

  18. The GEANT4 toolkit capability in the hadron therapy field: simulation of a transport beam line

    International Nuclear Information System (INIS)

    Cirrone, G.A.P.; Cuttone, G.; Di Rosa, F.; Raffaele, L.; Russo, G.; Guatelli, S.; Pia, M.G.

    2006-01-01

    At Laboratori Nazionali del Sud of the Instituto Nazionale di Fisica Nucleare of Catania (Sicily, Italy), the first Italian hadron therapy facility named CATANA (Centro di AdroTerapia ed Applicazioni Nucleari Avanzate) has been realized. Inside CATANA 62 MeV proton beams, accelerated by a superconducting cyclotron, are used for the radiotherapeutic treatments of some types of ocular tumours. Therapy with hadron beams still represents a pioneer technique, and only a few centers worldwide can provide this advanced specialized cancer treatment. On the basis of the experience so far gained, and considering the future hadron-therapy facilities to be developed (Rinecker, Munich Germany, Heidelberg/GSI, Darmstadt, Germany, PSI Villigen, Switzerland, CNAO, Pavia, Italy, Centro di Adroterapia, Catania, Italy) we decided to develop a Monte Carlo application based on the GEANT4 toolkit, for the design, the realization and the optimization of a proton-therapy beam line. Another feature of our project is to provide a general tool able to study the interactions of hadrons with the human tissue and to test the analytical-based treatment planning systems actually used in the routine practice. All the typical elements of a hadron-therapy line, such as diffusers, range shifters, collimators and detectors were modelled. In particular, we simulated the Markus type ionization chamber and a Gaf Chromic film as dosimeters to reconstruct the depth (Bragg peak and Spread Out Bragg Peak) and lateral dose distributions, respectively. We validated our simulated detectors comparing the results with the experimental data available in our facility

  19. A dedicated beam line for Rutherford backscattering analysis at IFIN-HH cyclotron

    International Nuclear Information System (INIS)

    Ivanov, E. A.; Dudu, D.; Plostinaru, D.; Catana, D.; Vata, I.

    2003-01-01

    Rutherford back-scattering technique (RBS) is an analytical tool that uses elastic scattering of 1-5 MeV charged particles for analysis of the surface and the outer few micrometers of solids. IFIN-HH RBS system consists of the U-120 Cyclotron, a dedicated beam line and a scattering chamber with sample manipulators and particle detectors. In our RBS system the samples are bombarded with 2-5 alpha particles accelerated by U-120 Cyclotron (in 3-rd subharmonic regime) while the scattered particles are detected by a surface barrier detector. The signal from the detector is processed by common nuclear electronics and the particle energy spectra are stored in a computer based multichannel analyser. The data evaluation is accomplished using standard procedures and computer codes. The necessary vacuum inside chamber is obtained with an oil-free turbo pump. The beam spot dimension on the target is 1x1 mm. The standard measurement are done at Θ = 165 angle. The samples are electrically insulated and can be rotated around a vertical axis. The advantage of the RBS technique lies in the quantitative analysis of major and minor constituents lying in the first 0.5 to 2.0 micrometers of a material. Depending on the sample structure and composition, the detection limits vary from 10 11 to 10 15 at. cm -2 for heavy and light elements, respectively. The depth distribution of constituents can be reconstructed with a depth resolution of 10-20 nm. The RBS technique is non-destructive since the erosion and the radiation degradation of the sample material by the particle impact is negligible. The most extensive use of the RBS technique is in the field of electronic and optical materials, special coatings and in the study of various physico-chemical processes on the solid surfaces. (authors)

  20. The GEANT4 toolkit capability in the hadron therapy field: simulation of a transport beam line

    Science.gov (United States)

    Cirrone, G. A. P.; Cuttone, G.; Di Rosa, F.; Raffaele, L.; Russo, G.; Guatelli, S.; Pia, M. G.

    2006-01-01

    At Laboratori Nazionali del Sud of the Instituto Nazionale di Fisica Nucleare of Catania (Sicily, Italy), the first Italian hadron therapy facility named CATANA (Centro di AdroTerapia ed Applicazioni Nucleari Avanzate) has been realized. Inside CATANA 62 MeV proton beams, accelerated by a superconducting cyclotron, are used for the radiotherapeutic treatments of some types of ocular tumours. Therapy with hadron beams still represents a pioneer technique, and only a few centers worldwide can provide this advanced specialized cancer treatment. On the basis of the experience so far gained, and considering the future hadron-therapy facilities to be developed (Rinecker, Munich Germany, Heidelberg/GSI, Darmstadt, Germany, PSI Villigen, Switzerland, CNAO, Pavia, Italy, Centro di Adroterapia, Catania, Italy) we decided to develop a Monte Carlo application based on the GEANT4 toolkit, for the design, the realization and the optimization of a proton-therapy beam line. Another feature of our project is to provide a general tool able to study the interactions of hadrons with the human tissue and to test the analytical-based treatment planning systems actually used in the routine practice. All the typical elements of a hadron-therapy line, such as diffusers, range shifters, collimators and detectors were modelled. In particular, we simulated the Markus type ionization chamber and a Gaf Chromic film as dosimeters to reconstruct the depth (Bragg peak and Spread Out Bragg Peak) and lateral dose distributions, respectively. We validated our simulated detectors comparing the results with the experimental data available in our facility.

  1. The GEANT4 toolkit capability in the hadron therapy field: simulation of a transport beam line

    Energy Technology Data Exchange (ETDEWEB)

    Cirrone, G.A.P. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, Catania (Italy); Cuttone, G. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, Catania (Italy); Di Rosa, F. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, Catania (Italy); Raffaele, L. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, Catania (Italy); Russo, G. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, Catania (Italy); Guatelli, S. [Istituto Nazionale di Fisica Nucleare, Sezione di Genova, Via Dodecaneso 33, Genova (Italy); Pia, M.G. [Istituto Nazionale di Fisica Nucleare, Sezione di Genova, Via Dodecaneso 33, Genova (Italy)

    2006-01-15

    At Laboratori Nazionali del Sud of the Instituto Nazionale di Fisica Nucleare of Catania (Sicily, Italy), the first Italian hadron therapy facility named CATANA (Centro di AdroTerapia ed Applicazioni Nucleari Avanzate) has been realized. Inside CATANA 62 MeV proton beams, accelerated by a superconducting cyclotron, are used for the radiotherapeutic treatments of some types of ocular tumours. Therapy with hadron beams still represents a pioneer technique, and only a few centers worldwide can provide this advanced specialized cancer treatment. On the basis of the experience so far gained, and considering the future hadron-therapy facilities to be developed (Rinecker, Munich Germany, Heidelberg/GSI, Darmstadt, Germany, PSI Villigen, Switzerland, CNAO, Pavia, Italy, Centro di Adroterapia, Catania, Italy) we decided to develop a Monte Carlo application based on the GEANT4 toolkit, for the design, the realization and the optimization of a proton-therapy beam line. Another feature of our project is to provide a general tool able to study the interactions of hadrons with the human tissue and to test the analytical-based treatment planning systems actually used in the routine practice. All the typical elements of a hadron-therapy line, such as diffusers, range shifters, collimators and detectors were modelled. In particular, we simulated the Markus type ionization chamber and a Gaf Chromic film as dosimeters to reconstruct the depth (Bragg peak and Spread Out Bragg Peak) and lateral dose distributions, respectively. We validated our simulated detectors comparing the results with the experimental data available in our facility.

  2. Parametric study of transport beam lines for electron beams accelerated by laser-plasma interaction

    Science.gov (United States)

    Scisciò, M.; Lancia, L.; Migliorati, M.; Mostacci, A.; Palumbo, L.; Papaphilippou, Y.; Antici, P.

    2016-03-01

    In the last decade, laser-plasma acceleration of high-energy electrons has attracted strong attention in different fields. Electrons with maximum energies in the GeV range can be laser-accelerated within a few cm using multi-hundreds terawatt (TW) lasers, yielding to very high beam currents at the source (electron bunches with up to tens-hundreds of pC in a few fs). While initially the challenge was to increase the maximum achievable electron energy, today strong effort is put in the control and usability of these laser-generated beams that still lack of some features in order to be used for applications where currently conventional, radio-frequency (RF) based, electron beam lines represent the most common and efficient solution. Several improvements have been suggested for this purpose, some of them acting directly on the plasma source, some using beam shaping tools located downstream. Concerning the latter, several studies have suggested the use of conventional accelerator magnetic devices (such as quadrupoles and solenoids) as an easy implementable solution when the laser-plasma accelerated beam requires optimization. In this paper, we report on a parametric study related to the transport of electron beams accelerated by laser-plasma interaction, using conventional accelerator elements and tools. We focus on both, high energy electron beams in the GeV range, as produced on petawatt (PW) class laser systems, and on lower energy electron beams in the hundreds of MeV range, as nowadays routinely obtained on commercially available multi-hundred TW laser systems. For both scenarios, our study allows understanding what are the crucial parameters that enable laser-plasma accelerators to compete with conventional ones and allow for a beam transport. We show that suitable working points require a tradeoff-combination between low beam divergence and narrow energy spread.

  3. Design and Status of the ELIMED Beam Line for Laser-Driven Ion Beams

    Directory of Open Access Journals (Sweden)

    G. A. Pablo Cirrone

    2015-08-01

    Full Text Available Charged particle acceleration using ultra-intense and ultra-short laser pulses has gathered a strong interest in the scientific community and it is now one of the most attractive topics in the relativistic laser-plasma interaction research. Indeed, it could represent the future of particle acceleration and open new scenarios in multidisciplinary fields, in particular, medical applications. One of the biggest challenges consists of using, in a future perspective, high intensity laser-target interaction to generate high-energy ions for therapeutic purposes, eventually replacing the old paradigm of acceleration, characterized by huge and complex machines. The peculiarities of laser-driven beams led to develop new strategies and advanced techniques for transport, diagnostics and dosimetry of the accelerated particles, due to the wide energy spread, the angular divergence and the extremely intense pulses. In this framework, the realization of the ELIMED (ELI-Beamlines MEDical applications beamline, developed by INFN-LNS (Catania, Italy and installed in 2017 as a part of the ELIMAIA beamline at the ELI-Beamlines (Extreme Light Infrastructure Beamlines facility in Prague, has the aim to investigate the feasibility of using laser-driven ion beams in multidisciplinary applications. ELIMED will represent the first user’s open transport beam line where a controlled laser-driven ion beam will be used for multidisciplinary and medical studies. In this paper, an overview of the beamline, with a detailed description of the main transport elements, will be presented. Moreover, a description of the detectors dedicated to diagnostics and dosimetry will be reported, with some preliminary results obtained both with accelerator-driven and laser-driven beams.

  4. Development of Multiple-Element Flame Emission Spectrometer Using CCD Detection

    Science.gov (United States)

    Seney, Caryn S.; Sinclair, Karen V.; Bright, Robin M.; Momoh, Paul O.; Bozeman, Amelia D.

    2005-01-01

    The full wavelength coverage of charge coupled device (CCD) detector when coupled with an echelle spectrography, the system allows for simultaneously multiple element spectroscopy to be performed. The multiple-element flame spectrometer was built and characterized through the analysis of environmentally significant elements such as Ca, K, Na, Cu,…

  5. In situ baking method for degassing of a kicker magnet in accelerator beam line

    International Nuclear Information System (INIS)

    Kamiya, Junichiro; Ogiwara, Norio; Yanagibashi, Toru; Kinsho, Michikazu; Yasuda, Yuichi

    2016-01-01

    In this study, the authors propose a new in situ degassing method by which only kicker magnets in the accelerator beam line are baked out without raising the temperature of the vacuum chamber to prevent unwanted thermal expansion of the chamber. By simply installing the heater and thermal radiation shield plates between the kicker magnet and the chamber wall, most of the heat flux from the heater directs toward the kicker magnet. The result of the verification test showed that each part of the kicker magnet was heated to above the target temperature with a small rise in the vacuum chamber temperature. A graphite heater was selected in this application to bake-out the kicker magnet in the beam line to ensure reliability and easy maintainability of the heater. The vacuum characteristics of graphite were suitable for heater operation in the beam line. A preliminary heat-up test conducted in the accelerator beam line also showed that each part of the kicker magnet was successfully heated and that thermal expansion of the chamber was negligibly small

  6. In situ baking method for degassing of a kicker magnet in accelerator beam line

    Energy Technology Data Exchange (ETDEWEB)

    Kamiya, Junichiro, E-mail: kamiya.junichiro@jaea.go.jp; Ogiwara, Norio; Yanagibashi, Toru; Kinsho, Michikazu [Japan Atomic Energy Agency, J-PARC Center, Ooaza Shirakata 2-4, Tokai, Naka, Ibaraki 319-1195 (Japan); Yasuda, Yuichi [SAKAGUCHI E.H VOC CORP., Sakura Dai-san Kogyodanchi 1-8-6, Osaku, Sakura, Chiba 285-0802 (Japan)

    2016-03-15

    In this study, the authors propose a new in situ degassing method by which only kicker magnets in the accelerator beam line are baked out without raising the temperature of the vacuum chamber to prevent unwanted thermal expansion of the chamber. By simply installing the heater and thermal radiation shield plates between the kicker magnet and the chamber wall, most of the heat flux from the heater directs toward the kicker magnet. The result of the verification test showed that each part of the kicker magnet was heated to above the target temperature with a small rise in the vacuum chamber temperature. A graphite heater was selected in this application to bake-out the kicker magnet in the beam line to ensure reliability and easy maintainability of the heater. The vacuum characteristics of graphite were suitable for heater operation in the beam line. A preliminary heat-up test conducted in the accelerator beam line also showed that each part of the kicker magnet was successfully heated and that thermal expansion of the chamber was negligibly small.

  7. Designing of the Low Energy Beam Lines with Achromatic Condition in the RAON Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Hyunchang; Jang, Ji-Ho; Jeon, Dong-O [Institute for Basic Science, Daejeon (Korea, Republic of)

    2017-01-15

    The RAON accelerator has been built to create and accelerate stable heavy-ion beams and rare isotope beams. The stable heavy-ion beams are generated by the superconducting electron cyclotron resonance ion source and accelerated by the low energy superconducting linac SCL1. The beams accelerated by the SCL1 are re-accelerated by the high energy superconducting linac SCL2 for the generation of rare isotope beams by using the in-flight fragmentation system or are put to use in the low energy experimental halls, which include the neutron science facility and the Korea Broad acceptance Recoil spectrometer and Apparatus after having passed through the low energy beam lines which have long deflecting sections. At the end of each beam line in the low energy experimental halls, the beams should meet the targets of the two facilities with the specific requirements satisfied. Namely, if the beam is to be sent safely and accurately to the targets and simultaneously, satisfy the requirements, an achromatic lattice design needs to be applied in each beam line. In this paper, we will present the lattice design of the low energy beam lines and describe the results of the beam dynamics simulations. In addition, the correction of the beam orbit, which is distorted by machine imperfections, will be discussed.

  8. Commissioning status of the decelerator test beam line in CTF3

    CERN Document Server

    Adli, E; Lillestol, R; Olvegaard, M; Syratchev, I; Carrillo, D; Toral, F; Faus-Golfe, A; Garcia-Garrigos, J J; Kubyshin, Y; Montoro, G

    2010-01-01

    The CLIC Test Facility (CTF3) at CERN was constructed by the CTF3 collaboration to study the feasibility of the concepts for a compact linear collider. The test beam line (TBL) recently added to the CTF3 machine was designed to study the CLIC decelerator beam dynamics and 12 GHz power production. The beam line consists of a FODO lattice with high precision BPM’s and quadrupoles on movers for precise beam alignment. A total of 16 Power Extraction and Transfer Structures (PETS) will be installed in between the quadrupoles to extract 12 GHz power from the drive beam provided by the CTF3 machine. The CTF3 drive beam with a bunch-train length of 140 ns, 12 GHz bunch repetition frequency and an average current over the train of up to 28 A will be injected into the test beam line. Each PETS structure will produce 135 MW of 12 GHz power at nominal current. The beam will have lost more than 50 % of its initial energy of 150 MeV at the end of the beam line and will contain particles with energies between 65 MeV and 1...

  9. A GIF++ Gamma Irradiation Facility at the SPS H4 Beam Line

    CERN Document Server

    Capéans-Garrido, M; Linssen, L; Moll, M; Rembser, C

    2009-01-01

    The current document describes a proposal to implement a new gamma irradiation facility, combined with a high-energy particle beam in the SPS H4 beam line in hall EHN1. This new GIF++ facility is motivated by strong needs from the LHC and sLHC detector and accelerator communities for the tests of LHC components and systems.

  10. Application of object oriented techniques in the TRIUMF beam line 2C control system

    International Nuclear Information System (INIS)

    Wilkinson, N.A.; Ludgate, G.A.

    1992-07-01

    The KAON Factory central control system study employed a uniform approach to requirements analysis, architectural design and programming based on well established object oriented principles. These principles were applied to the successful analysis, design and implementation of the control system for the TRIUMF Beam Line 2C Solid Target Facility. The specification for this control system was created in collaboration with Beam Line 2C equipment management experts and, once the analysis models were validated, an approach was developed for the direct translation of these models into C code. A commercial real time database was central to this translation, as inter-object data and control flows are implemented by channels in the database. This paper focuses on the experience gained in the use of object oriented techniques during the complete analysis-design-implementation cycle of a working control system and on the utility of implementing such a system using a commercial real time database and graphical interface. (author)

  11. Beam-line considerations for experiments with highly-charged ions

    International Nuclear Information System (INIS)

    Johnson, B.M.

    1990-01-01

    The APS offers exciting possibilities for a bright future in x-ray research. For example, measurements on the inner-shell photoionization of ions will be feasible using stored ions in ions traps or ion beams from an electron-cyclotron-resonance ion source, or perhaps even a heavy-ion storage ring. Such experiments with ionic targets are the focus for the discussion given here on the optimization of photon flux on a generic beamline at the APS. The performance of beam lines X26C, X26A, and X17 on the x-ray ring of the National Synchrotron Light Source will be discussed as specific examples of beam-line design considerations

  12. Beam-line considerations for experiments with highly-charged ions

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, B.M.

    1990-01-01

    The APS offers exciting possibilities for a bright future in x-ray research. For example, measurements on the inner-shell photoionization of ions will be feasible using stored ions in ions traps or ion beams from an electron-cyclotron-resonance ion source, or perhaps even a heavy-ion storage ring. Such experiments with ionic targets are the focus for the discussion given here on the optimization of photon flux on a generic beamline at the APS. The performance of beam lines X26C, X26A, and X17 on the x-ray ring of the National Synchrotron Light Source will be discussed as specific examples of beam-line design considerations.

  13. Status of the ELIMED multidisciplinary and medical beam-line at ELI-Beamlines

    International Nuclear Information System (INIS)

    Romano, F; Cirrone, G A P; Cuttone, G; Schillaci, F; Scuderi, V; Amico, A; Candiano, G; Larosa, G; Leanza, R; Manna, R; Marchese, V; Milluzzo, G; Petringa, G; Pipek, J; Giordanengo, S; Guarachi, L F; Marchetto, F; Sacchi, R; Korn, G; Margarone, D

    2017-01-01

    Nowadays, one of the biggest challenges consists in using high intensity laser-target interaction to generate high-energy ions for medical purposes, eventually replacing the old paradigm of acceleration characterized by huge and complex machines. In order to investigate the feasibility of using laser-driven ion beams for multidisciplinary application, a dedicated beam transport line will be installed at the ELI-Beamlines facility in Prague (CZ), as a part of the User-oriented ELIMAIA beam-line dedicated to ion acceleration and their potential applications. The beam-line section dedicated to transport and dosimetric endpoints is called ELIMED (ELI-Beamlines MEDical and multidisciplinary applications) and will be developed by the INFN-LNS. (paper)

  14. The Beam Line X NdFe-steel hybrid wiggler for SSRL

    International Nuclear Information System (INIS)

    Hoyer, E.; Halbach, K.; Humphries, D.; Marks, S.; Plate, D.; Shuman, D.; Karpenko, V.P.; Kulkarni, S.; Tirsell, K.G.

    1987-01-01

    A wiggler magnet with 15 periods, each 12.85 cm long, which achieves 1.40 T at a 2.1 cm gap (2.26T at 0.8 cm) has been designed and is now in fabrication at LBL. This wiggler will be the radiation source of the high intensity synchrotron radiation beam line for the Beam Line X PRT facility at SSRL. The magnet utilizes Neodymium-Iron (NdFe) material and Vanadium Permendur (steel) in the hybrid configuration to achieve simultaneously a high magnetic field and short period. Magnetic field adjustment is with a driven chain and ball screw drive system. The magnetic structure is external to an s.s. vacuum chamber which has thin walls, 0.76 mm thickness, at each pole tip for higher field operation. Magnetic design, construction details and magnetic measurements are presented

  15. Selection and evaluation of an ultra high vacuum gate valve for Isabelle beam line vacuum system

    International Nuclear Information System (INIS)

    Foerster, C.L.; McCafferty, D.

    1980-01-01

    A minimum of eighty-four (84) Ultra High Vacuum Gate Valves will be utilized in ISABELLE to protect proton beam lines from catastrophic vacuum failure and to provide sector isolation for maintenance requirements. The valve to be selected must function at less than 1 x 10 -11 Torr pressure and be bakeable to 300 0 C in its open or closed position. In the open position, the valve must have an RF shield to make the beam line walls appear continuous. Several proposed designs were built and evaluated. The evaluation consisted mainly of leak testing, life tests, thermal cycling, mass spectrometer analysis, and 10 -12 Torr operation. Problems with initial design and fabrication were resolved. Special requirements for design and construction were developed. This paper describes the tests on two final prototypes which appear to be the best candidates for ISABELLE operation

  16. FIRST BEAM TESTS OF THE MUON COLLIDER TARGET TEST BEAM LINE AT THE AGS

    International Nuclear Information System (INIS)

    BROWN, K.A.; GASSNER, D.; GLENN, J.W.; PRIGL, R.; SIMOS, N.; SCADUTO, J.; TSOUPAS, N.

    2001-01-01

    In this report we will describe the muon collider target test beam line which operates off one branch of the AGS switchyard. The muon collider target test facility is designed to allow a prototype muon collider target system to be developed and studied. The beam requirements for the facility are ambitious but feasible. The system is designed to accept bunched beams of intensities up to 1.6 x 10 13 24 GeV protons in a single bunch. The target specifications require beam spot sizes on the order of 1 mm, 1 sigma rms at the maximum intensity. We will describe the optics design, the instrumentation, and the shielding design. Results from the commissioning of the beam line will be shown

  17. Beam line 4: A dedicated surface science facility at Daresbury Laboratory

    International Nuclear Information System (INIS)

    Dhanak, V.R.; Robinson, A.W.; van der Laan, G.; Thornton, G.

    1992-01-01

    We describe a beam line currently under construction at the Daresbury Laboratory which forms part of a surface science research facility for the Interdisciplinary Research Centre in Surface Science. The beam line has three branches, two of which are described here. The first branch covers the high-energy range 640 eV≤hν≤10 keV, being equipped with a double-crystal monochromator and a novel multicoated premirror system. The second branch line is optimized for the energy range 15≤hν≤250 eV, using cylindrical focusing mirrors, a spherical diffraction grating and an ellipsoidal refocusing mirror to achieve high resolution with a small spot size

  18. 1 to 2 GeV/c beam line for hypernuclear and kaon research

    International Nuclear Information System (INIS)

    Chrien, R.E.

    1985-01-01

    A kaon beam line operating in the range from 1.0 to 2.0 GeV/c is proposed. The line is meant for kaon and pion research in a region hitherto inaccessible to experimenters. Topics in hypernuclear and kaon physics of high current interest include the investigation of doubly strange nuclear systems with the K - ,K + reaction, searching for dibaryon resonances, hyperon-nucleon interactions, hypernuclear γ rays, and associated production of excited hypernuclei. The beam line would provide separated beams of momentum analyzed kaons at intensities greater than 10 6 particles per spill with a momentum determined to one part in a thousand. This intensity is an order of magnitude greater than that currently available. 63 references

  19. Automated Sample Exchange Robots for the Structural Biology Beam Lines at the Photon Factory

    International Nuclear Information System (INIS)

    Hiraki, Masahiko; Watanabe, Shokei; Yamada, Yusuke; Matsugaki, Naohiro; Igarashi, Noriyuki; Gaponov, Yurii; Wakatsuki, Soichi

    2007-01-01

    We are now developing automated sample exchange robots for high-throughput protein crystallographic experiments for onsite use at synchrotron beam lines. It is part of the fully automated robotics systems being developed at the Photon Factory, for the purposes of protein crystallization, monitoring crystal growth, harvesting and freezing crystals, mounting the crystals inside a hutch and for data collection. We have already installed the sample exchange robots based on the SSRL automated mounting system at our insertion device beam lines BL-5A and AR-NW12A at the Photon Factory. In order to reduce the time required for sample exchange further, a prototype of a double-tonged system was developed. As a result of preliminary experiments with double-tonged robots, the sample exchange time was successfully reduced from 70 seconds to 10 seconds with the exception of the time required for pre-cooling and warming up the tongs

  20. National Synchrotron Light Source users manual: Guide to the VUV and x-ray beam lines

    International Nuclear Information System (INIS)

    Gmuer, N.F.; White-DePace, S.M.

    1987-08-01

    The success of the National Synchrotron Light Source in the years to come will be based, in large part, on the size of the users community and the diversity of the scientific disciplines represented by these users. In order to promote this philosophy, this National Synchrotron Light Source (NSLS) Users Manual: Guide to the VUV and X-Ray Beam Lines, has been published. This manual serves a number of purposes. In an effort to attract new research, it will present to the scientific community-at-large the current and projected architecture and capabilities of the various VUV and x-ray beam lines and storage rings. We anticipate that this publication will be updated periodically in order to keep pace with the constant changes at the NSLS

  1. An after-market, five-port vertical beam line extension for the PETtrace

    DEFF Research Database (Denmark)

    Barnhart, T. E.; Engle, J. W.; Severin, Gregory

    2012-01-01

    Most commercial cyclotrons intended for medical isotope production provide a limited number of beam ports crowded into a minimal vault space. Taking advantage of our new lab construction, we planned and installed a beam-line on port ♯2 of our GEMS PETtrace to bring beam to an additional 5 target...... positions. These are oriented in the vertical plane, with the downward directed beam well suited for molten target substrates. © 2012 American Institute of Physics...

  2. An electrostatic beam line for accelerator mass spectroscopy of exotic particles

    International Nuclear Information System (INIS)

    Elmore, D.; Kubik, P.W.; Hemmick, T.; Teng, R.; Kagan, H.; Haas, P.; Boyd, R.N.; Turner, R.; Nitz, D.; Ciampa, D.; Olsen, S.L.; Gentile, T.; Haelen, T.

    1985-01-01

    An all-electrostatic charged particle spectrometer has been constructed to perform high sensitivity searches for exotic states of matter. This spectrometer consists of an electrosatic beam line capable of mass independent charged particle transport and selection together with time-of-flight, energy loss and total energy detectors. This system has been used in conjunction with the tandem electrostatic accelerator at the Nuclear Structure Research Laboratory of the University of Rochester to search for fractionally charged or anomalously heavy particles. (orig.)

  3. An after-market, five-port vertical beam line extension for the PETtrace

    Science.gov (United States)

    Barnhart, T. E.; Engle, J. W.; Severin, G. W.; Valdovinos, H. F.; Gagnon, K.; Nickles, R. J.

    2012-12-01

    Most commercial cyclotrons intended for medical isotope production provide a limited number of beam ports crowded into a minimal vault space. Taking advantage of our new lab construction, we planned and installed a beam-line on port ♯2 of our GEMS PETtrace to bring beam to an additional 5 target positions. These are oriented in the vertical plane, with the downward directed beam well suited for molten target substrates.

  4. An after-market, five-port vertical beam line extension for the PETtrace

    Energy Technology Data Exchange (ETDEWEB)

    Barnhart, T. E.; Engle, J. W.; Severin, G. W.; Valdovinos, H. F.; Gagnon, K.; Nickles, R. J. [Department of Medical Physics, University of Wisconsin, Madison, WI (United States); Los Alamos National Lab, Los Alamos, NM (United States); Hevesy Laboratory, Danish Technical University, Riso (Denmark); Department of Medical Physics, University of Wisconsin, Madison, WI (United States); Department of Radiology, University of Washington, Seattle, WA (United States); Department of Medical Physics, University of Wisconsin, Madison, WI (United States)

    2012-12-19

    Most commercial cyclotrons intended for medical isotope production provide a limited number of beam ports crowded into a minimal vault space. Taking advantage of our new lab construction, we planned and installed a beam-line on port Music-Sharp-Sign 2 of our GEMS PETtrace to bring beam to an additional 5 target positions. These are oriented in the vertical plane, with the downward directed beam well suited for molten target substrates.

  5. The development of an expert system to tune a beam line

    International Nuclear Information System (INIS)

    Schultz, D.E.; Brown, P.A.; British Columbia Univ., Vancouver, BC

    1989-01-01

    The experience of developing an Expert System to aid in the tuning of the Ion Source Injection beam line at TRIUMF is described. The challenging and complex task of introducing Expert System technology into an established accelerator operation is outlined. Success in this environment depends strongly on the choice of project, the choice of experts, the choice of tools, and the methods used to represent the expertise. All these choices are discussed

  6. Operational experience with synchrotron light interferometers for CEBAF experimental beam lines

    Energy Technology Data Exchange (ETDEWEB)

    Pavel Chevtsov

    2006-10-24

    Beam size and energy spread monitoring systems based on Synchrotron Light Interferometers (SLI) have been in operations at Jefferson Lab for several years. A non-invasive nature and a very high (a few mm) resolution of SLI make these instruments valuable beam diagnostic tools for the CEBAF accelerator. This presentation describes the evolution of the Synchrotron Light Interferometer at Jefferson Lab and highlights our extensive experience in the installation and operation of the SLI for CEBAF experimental beam lines.

  7. Optical design of beam lines at the KEK-PS new experimental hall

    International Nuclear Information System (INIS)

    Tanaka, K.H.; Ieiri, M.; Noumi, H.; Minakawa, M.; Yamanoi, Y.; Kato, Y.; Ishii, H.; Suzuki, Y.; Takasaki, M.

    1995-01-01

    A new counter experimental hall [K.H. Tanaka et al., IEEE Trans. Magn. 28 (1992) 697] was designed and constructed at the KEK 12-GeV Proton Synchrotron (KEK-PS). The extracted proton beam from the KEK-PS is introduced to the new hall through the newly-prepared primary beam line, EP1, and hits two production targets in cascade. The upstream target provides secondary particles to the low momentum (0.4-0.6 GeV/c) separated beam line, K5, and the downstream target is connected to the medium momentum (0.6-2.0 GeV/c) separated beam line, K6. Several new ideas were employed in the beam optical designs of EP1, K5 and K6 in order to increase the number and the purity of the short-lived secondary particles, such as kaons and pions, under the limited energy and intensity of the primary protons provided by the KEK-PS. These new ideas are described in this paper as well as the first commissioning results. (orig.)

  8. Beam line optics technologies series (7). Orthopedic treatment of sharp of light (reflecting mirror)

    International Nuclear Information System (INIS)

    Uruga, Tomoya; Nomura, Masaharu

    2006-01-01

    A reflecting mirror (mirror) is the most popular light device for orthopedic treatment of the shape of light. The paper explains the kinds of mirror for hard X-ray field and its applications in order to think the objects of mirror and how to adjust it when user experiment on the beam-line. The basic knowledge of reflection of X-ray, a use of mirror, the kinds of condenser mirror, the influence factors on the condenser size, arrangement of mirror in the hard X-ray beam-line, what kinds of mirror are necessary, evaluation of performance of mirror and adjustment, and troubles and measures are described. Layout in optics hutch at BL01B1 at SPring-8, refraction and total reflection of X-rays at surface, reflectivity of Rh and Pt with ideal surface as a function of photon energy, effects of surface roughness on reflectivity of Rh, calculated beam sizes for typical SPring-8 mirror as a function of magnification, schematic drawing of mirror, standard mirror system for vertical deflection in bending magnet beam-line, and observed and calculated reflectivity of Rh double mirror at BL01B1 at SPring-8 are illustrated. (S.Y)

  9. Multiple orbital angular momentum generated by dielectric hybrid phase element

    Science.gov (United States)

    Wang, Xuewen; Kuchmizhak, Aleksandr; Hu, Dejiao; Li, Xiangping

    2017-09-01

    Vortex beam carrying multiple orbital angular momentum provides a new degree of freedom to manipulate light leading to the various exciting applications as trapping, quantum optics, information multiplexing, etc. Helical wavefront can be generated either via the geometric or the dynamic phase arising from a space-variant birefringence (q-plate) or from phase accumulation through propagation (spiral-phase-plate), respectively. Using fast direct laser writing technique we fabricate and characterize novel hybrid q-plate generating vortex beam simultaneously carrying two different high-order topological charges, which arise from the spin-orbital conversion and the azimuthal height variation of the recorded structures. We approve the versatile concept to generate multiple-OAM vortex beams combining the spin-orbital interaction and the phase accumulation in a single micro-scale device, a hybrid dielectric phase plate.

  10. A high intensity beam line of γ-rays up to 22MeV energy based on Compton backscattering

    International Nuclear Information System (INIS)

    Guo, W.; Xu, W.; Chen, J.G.; Ma, Y.G.; Cai, X.Z.; Wang, H.W.; Xu, Y.; Wang, C.B.; Lu, G.C.; Tian, W.D.; Yuan, R.Y.; Xu, J.Q.; Wei, Z.Y.; Yan, Z.; Shen, W.Q.

    2007-01-01

    Shanghai Laser Electron Gamma Source, a high intensity beam line of γ-ray, has been proposed recently. The beam line is expected to generate γ-rays up to the maximum energy of 22MeV by Compton backscattering between a CO 2 laser and electrons in the 3.5 GeV storage ring of the Shanghai Synchrotron Radiation Facility. The flux of non-collimated γ-rays is estimated to be 10 9 -10 10 s -1 when a CO 2 laser of several hundred Watt power is employed. We will discuss physics issues in the design and optimization of the beam line

  11. Design of mirror and monochromator crystals for a high-resolution multiwavelength anomalous diffraction beam line on a bending magnet at the ESRF

    International Nuclear Information System (INIS)

    Roth, M.; Ferrer, J.; Simon, J.; Geissler, E.

    1992-01-01

    High intensity for diffraction experiments with high-energy resolution on an intense x-ray beam, like the bending magnet beam lines at the ESRF, requires a strict control of the curvature of the optical elements placed in the beam for geometrical focusing and for wavelength monochromatization. Unwanted curvatures can come from nonuniform and variable heating of the optical elements produced by the absorption of x rays. To design the CRG/D2AM beam line described in the accompanying paper, some new techniques were developed to control these effects based on geometrical, i.e., topological, considerations. (1) Cooling of the entrance mirror: longitudinal curvature can be strongly reduced by cooling the mirror from the sides (and not from the rear) and only near the reflecting surface (i.e., not over the whole lateral surface). The cooling can be achieved for instance with an isothermal liquid Ga eutectic bath. (2) Cooling of the first single-crystal Si monochromator: because of the size of the crystal, only cooling from the rear is conceivable in this case. It can be shown by calculation that the curvature due to the front-to-rear gradient can be exactly compensated by the thermal expansion of a metallic layer at the rear of the crystal, having a larger expansion coefficient than Si

  12. Coulomb field strength measurement by electro-optic spectral decoding system at the CALIFES beam line

    CERN Document Server

    Pan, R; Lefevre, T; Gillepsie, WA; CERN. Geneva. ATS Department

    2016-01-01

    Electro-optic (EO) techniques are increasingly used for longitudinal bunch profile measurements. A bunch profile monitor, based on electro-optic spectral decoding(EOSD), has been developed and demonstrated on the CALIFES beam line at CERN. The EO response is analysed using a frequency domain description, and two methods for extraction of absolute Coulomb field strengths from the electron bunch are demonstrated. Measurements at field strengths up to 1.3 MV/m agree with the expectation based on independent charge measurements.

  13. An EXAFS spectrometer on beam line 10B at the Photon Factory

    International Nuclear Information System (INIS)

    Oyanagi, Hiroyuki; Matsushita, Tadashi; Ito, Masahisa; Kuroda, Haruo.

    1984-03-01

    An EXAFS spectrometer installed on the beam line 10B at the Photon Factory is designed to cover the photon energy between 4 and 30 keV. Utilizing either a channel-cut or two flat silicon crystals as a monochromator, a beam intensity between 10 8 and 10 9 photons/sec is obtained at 9 keV with a resolution of 1 eV. The performance of the spectrometer, such as a signal-to-noise ratio or an energy resolution is demonstrated with examples of K edge absorption spectra of bromine, germanium, gallium arsenide, and zinc selenide. (author)

  14. 100 years of elementary particles [Beam Line, vol. 27, issue 1, Spring 1997

    Energy Technology Data Exchange (ETDEWEB)

    Pais, Abraham; Weinberg, Steven; Quigg, Chris; Riordan, Michael; Panofsky, Wolfgang K.H.; Trimble, Virginia

    1997-04-01

    This issue of Beam Line commemorates the 100th anniversary of the April 30, 1897 report of the discovery of the electron by J.J. Thomson and the ensuing discovery of other subatomic particles. In the first three articles, theorists Abraham Pais, Steven Weinberg, and Chris Quigg provide their perspectives on the discoveries of elementary particles as well as the implications and future directions resulting from these discoveries. In the following three articles, Michael Riordan, Wolfgang Panofsky, and Virginia Trimble apply our knowledge about elementary particles to high-energy research, electronics technology, and understanding the origin and evolution of our Universe.

  15. 100 years of elementary particles [Beam Line, vol. 27, number 1, Spring 1997

    International Nuclear Information System (INIS)

    Pais, Abraham; Weinberg, Steven; Quigg, Chris; Riordan, Michael; Panofsky, Wolfgang K.H.; Trimble, Virginia

    1997-01-01

    This issue of Beam Line commemorates the 100th anniversary of the April 30, 1897 report of the discovery of the electron by J.J. Thomson and the ensuing discovery of other subatomic particles. In the first three articles, theorists Abraham Pais, Steven Weinberg, and Chris Quigg provide their perspectives on the discoveries of elementary particles as well as the implications and future directions resulting from these discoveries. In the following three articles, Michael Riordan, Wolfgang Panofsky, and Virginia Trimble apply our knowledge about elementary particles to high-energy research, electronics technology, and understanding the origin and evolution of our Universe

  16. Defocusing beam line design for an irradiation facility at the TAEA SANAEM Proton Accelerator Facility

    CERN Document Server

    Gencer, A.; Efthymiopoulos, I.; Yiğitoğlu, M.

    2016-01-01

    Electronic components must be tested to ensure reliable performance in high radiation environments such as Hi-Limu LHC and space. We propose a defocusing beam line to perform proton irradiation tests in Turkey. The Turkish Atomic Energy Authority SANAEM Proton Accelerator Facility was inaugurated in May 2012 for radioisotope production. The facility has also an R&D room for research purposes. The accelerator produces protons with 30 MeV kinetic energy and the beam current is variable between View the MathML source10μA and View the MathML source1.2mA. The beam kinetic energy is suitable for irradiation tests, however the beam current is high and therefore the flux must be lowered. We plan to build a defocusing beam line (DBL) in order to enlarge the beam size, reduce the flux to match the required specifications for the irradiation tests. Current design includes the beam transport and the final focusing magnets to blow up the beam. Scattering foils and a collimator is placed for the reduction of the beam ...

  17. E-line: A new crystal collimator beam line for source size measurements at CHESS

    Energy Technology Data Exchange (ETDEWEB)

    White, Jeffrey A. [CHESS, Cornell High Energy Synchrotron Source, Cornell University, Ithaca, NY 14850-8001 (United States)], E-mail: jaw7@cornell.edu; Revesz, Peter; Finkelstein, Ken [CHESS, Cornell High Energy Synchrotron Source, Cornell University, Ithaca, NY 14850-8001 (United States)

    2007-11-11

    A new X-ray beam line has been constructed at cornell high energy synchrotron source (CHESS) to measure the vertical and horizontal source size of the positron particle beam. The cornell laboratory of elementary particle physics (LEPP) operates the storage ring (CESR) for X-ray generation for the CHESS user community by circulating electrons and their antimatter counterpart positrons in counter-rotating beams. As the laboratory reduces the emittances of particle beams to increase X-ray brilliance, there has been an increasing need for diagnostic tools to measure and monitor source size. A beam line front end that accesses the positron synchrotron light has been fitted with an experimental chamber and apparatus of compact design capable of horizontal and vertical source size measurement using the 'crystal collimator' technique, and an additional setup for vertical beam position monitoring using a luminescence-based X-ray video beam position monitoring system. The crystal collimators each consist of two Si(2 2 0) crystals in a dispersive (+,+) arrangement that diffract X-rays to a fluorescent material coated on a view port observed with a CCD camera. Measurements of the positron vertical beam size using the crystal collimation method at E-line are compared with measurements of visible synchrotron light at a remotely located dedicated port on the storage ring.

  18. E-line: A new crystal collimator beam line for source size measurements at CHESS

    International Nuclear Information System (INIS)

    White, Jeffrey A.; Revesz, Peter; Finkelstein, Ken

    2007-01-01

    A new X-ray beam line has been constructed at cornell high energy synchrotron source (CHESS) to measure the vertical and horizontal source size of the positron particle beam. The cornell laboratory of elementary particle physics (LEPP) operates the storage ring (CESR) for X-ray generation for the CHESS user community by circulating electrons and their antimatter counterpart positrons in counter-rotating beams. As the laboratory reduces the emittances of particle beams to increase X-ray brilliance, there has been an increasing need for diagnostic tools to measure and monitor source size. A beam line front end that accesses the positron synchrotron light has been fitted with an experimental chamber and apparatus of compact design capable of horizontal and vertical source size measurement using the 'crystal collimator' technique, and an additional setup for vertical beam position monitoring using a luminescence-based X-ray video beam position monitoring system. The crystal collimators each consist of two Si(2 2 0) crystals in a dispersive (+,+) arrangement that diffract X-rays to a fluorescent material coated on a view port observed with a CCD camera. Measurements of the positron vertical beam size using the crystal collimation method at E-line are compared with measurements of visible synchrotron light at a remotely located dedicated port on the storage ring

  19. Lessons from shielding retrofits at the LAMPF/LANSCE/PSR accelerator, beam lines and target facilities

    International Nuclear Information System (INIS)

    Macek, R.J.

    1994-01-01

    The experience in the past 7 years to improve the shielding and radiation control systems at the Los Alamos Meson Physics Facility (LAMPF) and the Manuel Lujan Jr. Neutron Scattering Center (LANSCE) provides important lessons for the design of radiation control systems at future, high beam power proton accelerator facilities. Major issues confronted and insight gained in developing shielding criteria and in the use of radiation interlocks are discussed. For accelerators and beam lines requiring hands-on-maintenance, our experience suggests that shielding criteria based on accident scenarios will be more demanding than criteria based on routinely encountered beam losses. Specification and analysis of the appropriate design basis accident become all important. Mitigation by active protection systems of the consequences of potential, but severe, prompt radiation accidents has been advocated as an alternate choice to shielding retrofits for risk management at both facilities. Acceptance of active protection systems has proven elusive primarily because of the difficulty in providing convincing proof that failure of active systems (to mitigate the accident) is incredible. Results from extensive shielding assessment studies are presented including data from experimental beam spill tests, comparisons with model estimates, and evidence bearing on the limitations of line-of-sight attenuation models in complex geometries. The scope and significant characteristics of major shielding retrofit projects at the LAMPF site are illustrated by the project to improve the shielding beneath a road over a multiuse, high-intensity beam line (Line D)

  20. A beam optics study of the biomedical beam line at a proton therapy facility

    International Nuclear Information System (INIS)

    Yun, Chong Cheoul; Kim, Jong-Won

    2007-01-01

    A biomedical beam line has been designed for the experimental area of a proton therapy facility to deliver mm to sub-mm size beams in the energy range of 20-50 MeV using the TRANSPORT/TURTLE beam optics codes and a newly-written program. The proton therapy facility is equipped with a 230 MeV fixed-energy cyclotron and an energy selection system based on a degrader and slits, so that beam currents available for therapy decrease at lower energies in the therapeutic beam energy range of 70-230 MeV. The new beam line system is composed of an energy-degrader, two slits, and three quadrupole magnets. The minimum beam sizes achievable at the focal point are estimated for the two energies of 50 and 20 MeV. The focused FWHM beam size is approximately 0.3 mm with an expected beam current of 20 pA when the beam energy is reduced to 50 MeV from 100 MeV, and roughly 0.8 mm with a current of 10 pA for a 20 MeV beam

  1. Heat flux estimation for neutral beam line components using inverse heat conduction procedures

    International Nuclear Information System (INIS)

    Bharathi, P.; Prahlad, V.; Quereshi, K.; Bansal, L.K.; Rambabu, S.; Sharma, S.K.; Parmar, S.; Patel, P.J.; Baruah, U.K.; Patel, Ravi

    2015-01-01

    In this work, we describe and compare the analytical IHCP methods such-as semi-infinite method, finite slab method and a numerical method called Stolz method for estimating the incident heat flux from the experimentally measured temperature data. In case of analytical methods, the finite time response of the sensor is needed to be accounted for an accurate power density estimations. The modified models corrected for the response time of the sensors are also discussed in this paper. Application of these methods using example temperature waveforms obtained on the SST1-NBI test stand is presented and discussed. For choosing the suitable method for the calorimetry on beam line components, the estimated results are also validated using the ANSYS analysis done on these beam Iine components. As a conclusion, the finite slab method corrected for the influence of the sensor response time found out to be the most suitable method for the inversion of temperature data in case of neutral beam line components

  2. The Challenge of Interfacing the Primary Beam Lines for the AWAKE Project at CERN

    CERN Document Server

    Bracco, C; Gschwendtner, E; Meddahi, M; Petrenko, A; Velotti, FM

    2014-01-01

    The Proton Driven Plasma Wakefield Acceleration Experiment (AWAKE) at CERN foresees the simultaneous operation of a proton, a laser and an electron beam. The first stage of the experiment will consist in proving the self-modulation, in the plasma, of a long proton bunch into micro-bunches. The success of this experiment requires an almost perfect concentricity of the proton and laser beam, over the full length of the plasma cell. The complexity of integrating the laser into the proton beam line and fulfilling the strict requirements in terms of pointing precision of the proton beam at the plasma cell are described. The second stage of the experiment foresees also the injection of electron bunches to probe the accelerating wakefields driven by the proton beam. Studies were performed to evaluate the possibility of injecting the electron beam parallel and with an offset to the beam axis. This option would imply that protons and electrons will have to share the last few meters of a common beam line. Issues and po...

  3. Design of active feedback controller used in the infrared beam line of SSRF

    International Nuclear Information System (INIS)

    Zhang Yongli; Tong Yajun; Zhang Zhaohong; Chen Min; Jiang Jianguo; Gong Peirong

    2014-01-01

    Background: The infrared beam line consists of many kinds of optical components that are susceptible to the external mechanical vibration, which will be further amplified by the long optical paths to seriously destroy the stability of infrared beam position. Purpose: The active feedback controller is used to stabilize the infrared beam position disturbed by the external environment. Methods: The design of the active feedback controller used in the infrared beam line of SSRF was proposed in this paper firstly, which included its background, light-path layout and operating process. Subsequently, the selections of the crucial components such as detector and actuator were discussed in details. Finally, the correction compensator design and its experimental test were also presented. The correction compensator design was realized by utilizing the frequency response method, and tested in time domain, frequency domain and mathematical model simulation of the controlled object. Results: The experimental tests included time domain step response signal of the controller, the time domain signal and its relevant magnitude spectrum in frequency domain due to the light source simulation vibration. Conclusion: The results show that the maximum effective operating band is 250 Hz and the maximum steady error is 5 μm. (authors)

  4. Defocusing beam line design for an irradiation facility at the TAEA SANAEM Proton Accelerator Facility

    Science.gov (United States)

    Gencer, A.; Demirköz, B.; Efthymiopoulos, I.; Yiğitoğlu, M.

    2016-07-01

    Electronic components must be tested to ensure reliable performance in high radiation environments such as Hi-Limu LHC and space. We propose a defocusing beam line to perform proton irradiation tests in Turkey. The Turkish Atomic Energy Authority SANAEM Proton Accelerator Facility was inaugurated in May 2012 for radioisotope production. The facility has also an R&D room for research purposes. The accelerator produces protons with 30 MeV kinetic energy and the beam current is variable between 10 μA and 1.2 mA. The beam kinetic energy is suitable for irradiation tests, however the beam current is high and therefore the flux must be lowered. We plan to build a defocusing beam line (DBL) in order to enlarge the beam size, reduce the flux to match the required specifications for the irradiation tests. Current design includes the beam transport and the final focusing magnets to blow up the beam. Scattering foils and a collimator is placed for the reduction of the beam flux. The DBL is designed to provide fluxes between 107 p /cm2 / s and 109 p /cm2 / s for performing irradiation tests in an area of 15.4 cm × 21.5 cm. The facility will be the first irradiation facility of its kind in Turkey.

  5. Design of the extraction arc for the 2nd beam line of the free-electron laser FLASH

    International Nuclear Information System (INIS)

    Scholz, Matthias

    2014-01-01

    In this thesis, I deal with the design of the extraction arc for the second beam line of FLASH, an FEL (Free-Electron Laser) user facility at DESY Hamburg. Both beam lines will use the same linear accelerator and their separation will take place behind the last accelerating module. I present the constraints for the extraction arc given by the beam line layout of the existing machine, by the building environment of the new beam line and in particular, by coherent synchrotron radiation (CSR). The impact from CSR is presented, and I show how to mitigate these effects and what that means for the beam line design. The optimization of the extraction arc was done applying the downhill simplex algorithm which is presented, first in its basic form to explain the operation principle and then in a more advanced version as used in the applied program. I introduce in this thesis the final layout of the extraction arc including the following matching section. This layout fulfills all given constraints and can provide the required electron beam quality for FEL operation. In order to prove this, I present start-to-end simulations for different bunch charges and for two different wavelengths.

  6. Development of a polarized neutron beam line at Algerian research reactors using McStas software

    Science.gov (United States)

    Makhloufi, M.; Salah, H.

    2017-02-01

    Unpolarized instrumentation has long been studied and designed using McStas simulation tool. But, only recently new models were developed for McStas to simulate polarized neutron scattering instruments. In the present contribution, we used McStas software to design a polarized neutron beam line, taking advantage of the available spectrometers reflectometer and diffractometer in Algeria. Both thermal and cold neutron was considered. The polarization was made by two types of supermirrors polarizers FeSi and CoCu provided by the HZB institute. For sake of performance and comparison, the polarizers were characterized and their characteristics reproduced. The simulated instruments are reported. Flipper and electromagnets for guide field are developed. Further developments including analyzers and upgrading of the existing spectrometers are underway.

  7. Operating experience with LAMPF main beam lines instrumentation and control system

    International Nuclear Information System (INIS)

    van Dyck, O.B.; Harvey, A.; Howard, H.H.; Roeder, D.L.

    1975-01-01

    Instrumentation and control (I and C) for the Los Alamos Clinton P. Anderson Meson Physics Facility (LAMPF) main beam line is based upon central computer control through remote stations which provide input and output to most devices. Operating experience shows that the ability of the computer to give high-quality graphical presentation of the measurements enhances operator performance and instrument usefulness. Experience also shows that operator efficiency degrades rapidly with increasing instrument response time, that is, with increasing delay between the time a control is changed and the result can be observed. For this reason, instrumentation upgrade includes speeding up data acquisition and display times to under 10 s. Similarly, television-viewed phosphors are being retained where possible since their instantaneous response is very useful. Other upgrading of the instrumentation system is planned to improve data accuracy, reliability, redundancy, and instrument radiation tolerance. Past experience is being applied in adding or relocating devices to simplify tuning procedures. (U.S.)

  8. High flux and high resolution VUV beam line for synchrotron radiation

    International Nuclear Information System (INIS)

    Wilcke, H.; Boehmer, W.; Schwentner, N.

    1982-04-01

    A beam line has been optimized for high flux and high resolution in the wavelength range from 30 nm to 300 nm. Sample chambers for luminescence spectroscopy on gaseous, liquid and solid samples and for photoelectron spectroscopy have been integrated. The synchrotron radiation from the storage ring DORIS (at DESY, Hamburg) emitted into 50 mrad in horizontal and into 2.2 mrad in vertical direction is focused by a cylindrical and a plane elliptical mirror into the entrance slit of a 2m normal incidence monochromator. The light flux from the exit slit is focused by a rotational elliptic mirror onto the sample yielding a size of the light spot of 4 x 0.15 mm 2 . The light flux at the sample reaches 7 x 10 12 photons nm -1 s -1 at 8 eV photon energy for a current of 100 mA in DORIS. A resolution of 0.007 nm has been obtained. (orig.)

  9. Proposal for characterization of muon spectrometers for neutrino beam lines with the Baby MIND

    CERN Document Server

    Noah, E

    2015-01-01

    Neutrino detectors based on state-of-the-art plastic scintillators read out with solid state photo-sensors, as well as new magnetization schemes, have been developed in the framework of AIDA. Meaningful size prototypes are under construction. In the framework of the CERN neutrino platform, we propose to test a Totally Active Scintillator Detector (TASD) and a prototype of a Magnetized Iron Neutrino Detector (MIND), called Baby MIND in the H8 beam line in 2016-2018. The design of the detectors and the purpose and plans for the beam tests are presented. An opportunity to use the Baby MIND detector in a real neutrino beam at JPARC for the measurement of the cross-section ratio between Water and scintillator (WAGASCI experiment) is described.

  10. Alignment of dipole magnet in micro-beam line of HIRFL

    International Nuclear Information System (INIS)

    Wang Shaoming; Chen Wenjun; Yang Shengli; Cai Guozhu; Guo Yizhen; Zhou Guangming; Man Kaidi; Song Mingtao

    2010-01-01

    Microbeam irradiation facility is an experiment platform, which can reduce the beam-spot on the irradiated sample to micrometer level, and can accurately locate and count the radioactive particles. It is a powerful research tool for the irradiation material science, irradiation biology, irradiation biomedicine and micro mechanical machining. The microbeam irradiation facility requires the precise work for installation and alignment. These conditions make magnet's change for directions and positions because the location space of dipole magnets in micro-beam line of HIRFL (Heavy Ion Research Facility in Lanzhou) is very small. It is a challenge for the installation and alignment work of magnets. It was solved by transforming coordinates of benchmarks of magnets, which controlled the error of magnet setup within error tolerance range. (authors)

  11. Time Resolved Spectrometry on the Test Beam Line at CTF3

    CERN Document Server

    Olvegård, M; Lefèvre, T; Döbert, S; Adli, E

    2009-01-01

    The CTF3 provides a high current (28 A) high frequency (12 GHz) electron beam, which is used to generate high power radiofrequency pulses at 12 GHz by decelerating the electrons in resonant structures. A Test Beam Line (TBL) is currently being built in order to prove the efficiency and the reliability of the RF power production with the lowest level of particle losses. As the beam propagates along the line, its energy spread grows up to 60%. For instrumentation, this unusual characteristic implies the development of new and innovative techniques. One of the most important tasks is to measure the beam energy spread with a fast time resolution. The detector must be able to detect the energy transient due to beam loading in the decelerating structures (nanosecond) but should also be capable to measure bunch-to-bunch fluctuations (12 GHz). This paper presents the design of the spectrometer line detectors.

  12. Muon Beam Studies in the H4 beam line and the Gamma Irradiation Facility (GIF++)

    CERN Document Server

    Margraf, Rachel; CERN. Geneva. ATS Department

    2018-01-01

    In this note, we present detailed simulation results for the trajectory of a muon beam, traversing beam zones PPE-134 and PPE-154, produced by a 150 GeV positive hadron beam incident on collimators 9 & 10 in the H4 beam line when these collimators are placed off-beam axis to stop all hadrons and electrons. Using G4Beamline, a GEANT-4 based Monte-Carlo program, the trajectory of the muon beam has been studied for several field strengths of the GOLIATH magnet, as well as for different polarities. The position of the beam at the Gamma Irradiation Facility (GIF++), located downstream the PPE-144 area, is also presented. In addition, two configurations of the two XTDV’s present in the line (XTDV.022.520 and XTDV.022.610) have been studied, with the purpose to simulate the pion contamination of the beam both in PPE134 and GIF++.

  13. Differential acceleration in the final beam lines of a Heavy Ion Fusion driver

    Energy Technology Data Exchange (ETDEWEB)

    Friedman, Alex, E-mail: af@llnl.gov [Lawrence Livermore National Laboratory, Livermore, CA 94550 (United States); The Virtual National Laboratory for Heavy Ion Fusion Science (United States)

    2014-01-01

    A long-standing challenge in the design of a Heavy Ion Fusion power plant is that the ion beams entering the target chamber, which number of order a hundred, all need to be routed from one or two multi-beam accelerators through a set of transport lines. The beams are divided into groups, each of which has a unique arrival time and may have a unique kinetic energy. It is also necessary to arrange for each beam to enter the target chamber from a prescribed location on the periphery of that chamber. Furthermore, it has generally been assumed that additional constraints must be obeyed: that the path lengths of the beams in a group must be equal, and that any delay of “main-pulse” beams relative to “foot-pulse” beams must be provided by the insertion of large delay-arcs in the main beam transport lines. Here we introduce the notion of applying “differential acceleration” to individual beams or sets of beams at strategic stages of the transport lines. That is, by accelerating some beams “sooner” and others “later,” it is possible to simplify the beam line configuration in a number of cases. For example, the time delay between the foot and main pulses can be generated without resorting to large arcs in the main-pulse beam lines. It is also possible to use differential acceleration to effect the simultaneous arrival on target of a set of beams (e.g., for the foot-pulse) without requiring that their path lengths be precisely equal. We illustrate the technique for two model configurations, one corresponding to a typical indirect-drive scenario requiring distinct foot and main energies, and the other to an ion-driven fast-ignition scenario wherein the foot and main beams share a common energy.

  14. Differential acceleration in the final beam lines of a Heavy Ion Fusion driver

    International Nuclear Information System (INIS)

    Friedman, Alex

    2014-01-01

    A long-standing challenge in the design of a Heavy Ion Fusion power plant is that the ion beams entering the target chamber, which number of order a hundred, all need to be routed from one or two multi-beam accelerators through a set of transport lines. The beams are divided into groups, each of which has a unique arrival time and may have a unique kinetic energy. It is also necessary to arrange for each beam to enter the target chamber from a prescribed location on the periphery of that chamber. Furthermore, it has generally been assumed that additional constraints must be obeyed: that the path lengths of the beams in a group must be equal, and that any delay of “main-pulse” beams relative to “foot-pulse” beams must be provided by the insertion of large delay-arcs in the main beam transport lines. Here we introduce the notion of applying “differential acceleration” to individual beams or sets of beams at strategic stages of the transport lines. That is, by accelerating some beams “sooner” and others “later,” it is possible to simplify the beam line configuration in a number of cases. For example, the time delay between the foot and main pulses can be generated without resorting to large arcs in the main-pulse beam lines. It is also possible to use differential acceleration to effect the simultaneous arrival on target of a set of beams (e.g., for the foot-pulse) without requiring that their path lengths be precisely equal. We illustrate the technique for two model configurations, one corresponding to a typical indirect-drive scenario requiring distinct foot and main energies, and the other to an ion-driven fast-ignition scenario wherein the foot and main beams share a common energy

  15. Multiobjective optimizations of a novel cryocooled dc gun based ultrafast electron diffraction beam line

    Directory of Open Access Journals (Sweden)

    Colwyn Gulliford

    2016-09-01

    Full Text Available We present the results of multiobjective genetic algorithm optimizations of a single-shot ultrafast electron diffraction beam line utilizing a 225 kV dc gun with a novel cryocooled photocathode system and buncher cavity. Optimizations of the transverse projected emittance as a function of bunch charge are presented and discussed in terms of the scaling laws derived in the charge saturation limit. Additionally, optimization of the transverse coherence length as a function of final rms bunch length at the sample location have been performed for three different sample radii: 50, 100, and 200  μm, for two final bunch charges: 10^{5} electrons (16 fC and 10^{6} electrons (160 fC. Example optimal solutions are analyzed, and the effects of disordered induced heating estimated. In particular, a relative coherence length of L_{c,x}/σ_{x}=0.27  nm/μm was obtained for a final bunch charge of 10^{5} electrons and final bunch length of σ_{t}≈100  fs. For a final charge of 10^{6} electrons the cryogun produces L_{c,x}/σ_{x}≈0.1  nm/μm for σ_{t}≈100–200  fs and σ_{x}≥50  μm. These results demonstrate the viability of using genetic algorithms in the design and operation of ultrafast electron diffraction beam lines.

  16. Superconducting magnet system for the J-PARC neutrino beam line. Development, construction and operation of superconducting magnets

    International Nuclear Information System (INIS)

    Sasaki, Ken-ichi; Nakamoto, Tatsushi; Ajima, Yasuo; Okamura, Takahiro; Ogitsu, Toru; Kimura, Nobuhiro; Terashima, Akio; Tomaru, Takayuki; Higashi, Norio

    2010-01-01

    Superconducting combined-function magnets have been utilized for the 50-GeV, 750-kW proton beam line in the J-PARC neutrino experiment. The magnets are designed to provide a dipole field of 2.6 T combined with a quadrupole field of 19 T/m in a coil aperture of 173.4 mm at a nominal current of 7,345 A. Following the success of a prototype R and D project, a superconducting magnet system for the J-PARC neutrino beam line has been constructed since 2005. Using a new conceptual beam line with the superconducting combined-function magnets has demonstrated successful beam transport to the target neutrino production. (author)

  17. The H line: a brand new beam line for fundamental physics at the J-PARC muon facility

    International Nuclear Information System (INIS)

    Kawamura, N; Shimomura, K; Miyake, Y; Toyoda, A; Saito, N; Mihara, S; Aoki, M

    2013-01-01

    The muon facility, J-PARC (Muon Science Establishment; MUSE), has been operated since first beam in 2008. Starting with a 200 kW proton beam, the beam intensity has reached 3×10 6 / muons/s, the most intense pulsed muon beam in the world. A 2 cm thick graphite target permits the extraction of four secondary muon beams. A brand new beam line, the H line, is planned to be constructed. The new beam line is designed to have a large acceptance, will provide the ability to tune the momentum, and use a kicker magnet and/or Wien filter. This beam line will provide an intense beam for experiments that require high statistics and must occupy the experimental areas for a relatively long period.

  18. Design and construction of UVSOR-BL4A2 beam line for nano-structure processing

    CERN Document Server

    Takezoe, N; Tanaka, T; Kurosawa, K; Nonogaki, Y; Noda, H; Mekaru, H; Urisu, T

    2001-01-01

    We have designed and constructed a new beam line BL4A2 at UVSOR mainly for nano-structure fabrication based on synchrotron radiation stimulated surface photochemical reactions. In order to obtain high-photon flux, we use white ray beam focused with only one mirror. The beam line is connected with ultra-high vacuum scanning tunneling microscope for in-situ atomic scale observations, low energy electron diffraction and Auger electron spectroscope for surface crystal structure characterization, and photo-stimulated surface reaction chamber. In order to monitor the optical properties with atomic scale, a near field optical microscope is planned to be installed.

  19. An extended range soft X-ray beam line for the 1 GeV storage ring Aladdin

    International Nuclear Information System (INIS)

    Hulbert, S.L.; Stott, J.P.; Brown, F.C.

    1983-01-01

    The design and implementation of a soft X-ray beam line on the new 1 GeV storage ring Aladdin in Stoughton, Wisconsin is discussed. The beam line consists of a long horizontally focussing collection mirror, an extended range (50-1500 eV) grasshopper monochromator, an ellipsoidal refocussing mirror, and a photoemission chamber. Also discussed are the factors considered in matching the monochromator to the storage ring, flux and performance expectations, and the results of a ray tracing analysis. (orig.)

  20. Design and construction of UVSOR-BL4A2 beam line for nano-structure processing

    International Nuclear Information System (INIS)

    Takezoe, N.; Yanagida, H.; Tanaka, T.; Kurosawa, K.; Nonogaki, Y.; Noda, H.; Mekaru, H.; Urisu, T.

    2001-01-01

    We have designed and constructed a new beam line BL4A2 at UVSOR mainly for nano-structure fabrication based on synchrotron radiation stimulated surface photochemical reactions. In order to obtain high-photon flux, we use white ray beam focused with only one mirror. The beam line is connected with ultra-high vacuum scanning tunneling microscope for in-situ atomic scale observations, low energy electron diffraction and Auger electron spectroscope for surface crystal structure characterization, and photo-stimulated surface reaction chamber. In order to monitor the optical properties with atomic scale, a near field optical microscope is planned to be installed

  1. Automatic treatment of multiple wound coils in 3D finite element problems including multiply connected regions

    Energy Technology Data Exchange (ETDEWEB)

    Leonard, P.J.; Lai, H.C.; Eastham, J.F.; Al-Akayshee, Q.H. [Univ. of Bath (United Kingdom)

    1996-05-01

    This paper describes an efficient scheme for incorporating multiple wire wound coils into 3D finite element models. The scheme is based on the magnetic scalar representation with an additional basis for each coil. There are no restrictions on the topology of coils with respect to ferromagnetic and conductor regions. Reduced scalar regions and cuts are automatically generated.

  2. Image quality improvement in megavoltage cone beam CT using an imaging beam line and a sintered pixelated array system

    International Nuclear Information System (INIS)

    Breitbach, Elizabeth K.; Maltz, Jonathan S.; Gangadharan, Bijumon; Bani-Hashemi, Ali; Anderson, Carryn M.; Bhatia, Sudershan K.; Stiles, Jared; Edwards, Drake S.; Flynn, Ryan T.

    2011-01-01

    Purpose: To quantify the improvement in megavoltage cone beam computed tomography (MVCBCT) image quality enabled by the combination of a 4.2 MV imaging beam line (IBL) with a carbon electron target and a detector system equipped with a novel sintered pixelated array (SPA) of translucent Gd 2 O 2 S ceramic scintillator. Clinical MVCBCT images are traditionally acquired with the same 6 MV treatment beam line (TBL) that is used for cancer treatment, a standard amorphous Si (a-Si) flat panel imager, and the Kodak Lanex Fast-B (LFB) scintillator. The IBL produces a greater fluence of keV-range photons than the TBL, to which the detector response is more optimal, and the SPA is a more efficient scintillator than the LFB. Methods: A prototype IBL + SPA system was installed on a Siemens Oncor linear accelerator equipped with the MVision TM image guided radiation therapy (IGRT) system. A SPA strip consisting of four neighboring tiles and measuring 40 cm by 10.96 cm in the crossplane and inplane directions, respectively, was installed in the flat panel imager. Head- and pelvis-sized phantom images were acquired at doses ranging from 3 to 60 cGy with three MVCBCT configurations: TBL + LFB, IBL + LFB, and IBL + SPA. Phantom image quality at each dose was quantified using the contrast-to-noise ratio (CNR) and modulation transfer function (MTF) metrics. Head and neck, thoracic, and pelvic (prostate) cancer patients were imaged with the three imaging system configurations at multiple doses ranging from 3 to 15 cGy. The systems were assessed qualitatively from the patient image data. Results: For head and neck and pelvis-sized phantom images, imaging doses of 3 cGy or greater, and relative electron densities of 1.09 and 1.48, the CNR average improvement factors for imaging system change of TBL + LFB to IBL + LFB, IBL + LFB to IBL + SPA, and TBL + LFB to IBL + SPA were 1.63 (p -8 ), 1.64 (p -13 ), 2.66 (p -9 ), respectively. For all imaging doses, soft tissue contrast was more

  3. Design of a synchrotron radiation detector for the test beam lines at the Superconducting Super Collider Laboratory

    International Nuclear Information System (INIS)

    Hutton, R.D.

    1994-01-01

    As part of the particle- and momentum-tagging instrumentation required for the test beam lines of the Superconducting Super Collider (SSC), the synchrotron radiation detector (SRD) was designed to provide electron tagging at momentum above 75 GeV. In a parallel effort to the three test beam lines at the SSC, schedule demands required testing and calibration operations to be initiated at Fermilab. Synchrotron radiation detectors also were to be installed in the NM and MW beam lines at Femilab before the test beam lines at the SSC would become operational. The SRD is the last instrument in a series of three used in the SSC test beam fines. It follows a 20-m drift section of beam tube downstream of the last silicon strip detector. A bending dipole just in of the last silicon strip detector produces the synchrotron radiation that is detected in a 50-mm-square cross section NaI crystal. A secondary scintillator made of Bicron BC-400 plastic is used to discriminate whether it is synchrotron radiation or a stray particle that causes the triggering of the NaI crystal's photo multiplier tube (PMT)

  4. Powerloads on the front end components and the duct of the heating and diagnostic neutral beam lines at ITER

    Energy Technology Data Exchange (ETDEWEB)

    Singh, M. J.; Boilson, D.; Hemsworth, R. S.; Geli, F.; Graceffa, J.; Urbani, M.; Schunke, B.; Chareyre, J. [ITER Organisation, 13607 St. Paul-Lez-Durance Cedex (France); Dlougach, E.; Krylov, A. [RRC Kurchatov institute, 1, Kurchatov Sq, Moscow, 123182 (Russian Federation)

    2015-04-08

    The heating and current drive beam lines (HNB) at ITER are expected to deliver ∼16.7 MW power per beam line for H beams at 870 keV and D beams at 1 MeV during the H-He and the DD/DT phases of ITER operation respectively. On the other hand the diagnostic neutral beam (DNB) line shall deliver ∼2 MW power for H beams at 100 keV during both the phases. The path lengths over which the beams from the HNB and DNB beam lines need to be transported are 25.6 m and 20.7 m respectively. The transport of the beams over these path lengths results in beam losses, mainly by the direct interception of the beam with the beam line components and reionisation. The lost power is deposited on the surfaces of the various components of the beam line. In order to ensure the survival of these components over the operational life time of ITER, it is important to determine to the best possible extent the operational power loads and power densities on the various surfaces which are impacted by the beam in one way or the other during its transport. The main factors contributing to these are the divergence of the beamlets and the halo fraction in the beam, the beam aiming, the horizontal and vertical misalignment of the beam, and the gas profile along the beam path, which determines the re-ionisation loss, and the re-ionisation cross sections. The estimations have been made using a combination of the modified version of the Monte Carlo Gas Flow code (MCGF) and the BTR code. The MCGF is used to determine the gas profile in the beam line and takes into account the active gas feed into the ion source and neutraliser, the HNB-DNB cross over, the gas entering the beamline from the ITER machine, the additional gas atoms generated in the beam line due to impacting ions and the pumping speed of the cryopumps. The BTR code has been used to obtain the power loads and the power densities on the various surfaces of the front end components and the duct modules for different scenarios of ITER

  5. Visual processing of multiple elements in the dyslexic brain: evidence for a superior parietal dysfunction

    Directory of Open Access Journals (Sweden)

    Muriel Anne Lobier

    2014-07-01

    Full Text Available The visual attention (VA span deficit hypothesis of developmental dyslexia posits that impaired multiple element processing can be responsible for poor reading outcomes. In VA span impaired dyslexic children, poor performance on letter report tasks is associated with reduced parietal activations for multiple letter processing. While this hints towards a non-specific, attention-based dysfunction, it is still unclear whether reduced parietal activity generalizes to other types of stimuli. Furthermore, putative links between reduced parietal activity and reduced ventral occipito-temporal (vOT in dyslexia have yet to be explored. Using fMRI, we measured brain activity in 12 VA span impaired dyslexic adults and 12 adult skilled readers while they carried out a categorization task on single or multiple alphanumeric or non-alphanumeric characters. While healthy readers activated parietal areas more strongly for multiple than single element processing (right-sided for alphanumeric and bilateral for non-alphanumeric, similar stronger multiple element right parietal activations were absent for dyslexic participants. Contrasts between skilled and dyslexic readers revealed significantly reduced right superior parietal lobule (SPL activity for dyslexic readers regardless of stimuli type. Using a priori anatomically defined ROI, we showed that neural activity was reduced for dyslexic participants in both SPL and vOT bilaterally. Finally, we used multiple regressions to test whether SPL activity could predict vOT activity in each group. In the left hemisphere, SPL activity modulated vOT activity for both normal and dyslexic readers. In contrast, in the right hemisphere, SPL activity modulated vOT activity only for dyslexic readers. These results bring critical support to the visual attention interpretation of the VA Span deficit. In addition, they offer a new insight on how deficits in automatic vOT based word recognition could arise in developmental dyslexia.

  6. Development of a polarized neutron beam line at Algerian research reactors using McStas software

    Energy Technology Data Exchange (ETDEWEB)

    Makhloufi, M., E-mail: makhloufi_8m@yahoo.fr [Centre de Recherche Nucléaire de Birine (Algeria); Salah, H. [Centre de Recherche Nucléaire d' Alger (Algeria)

    2017-02-01

    Unpolarized instrumentation has long been studied and designed using McStas simulation tool. But, only recently new models were developed for McStas to simulate polarized neutron scattering instruments. In the present contribution, we used McStas software to design a polarized neutron beam line, taking advantage of the available spectrometers reflectometer and diffractometer in Algeria. Both thermal and cold neutron was considered. The polarization was made by two types of supermirrors polarizers FeSi and CoCu provided by the HZB institute. For sake of performance and comparison, the polarizers were characterized and their characteristics reproduced. The simulated instruments are reported. Flipper and electromagnets for guide field are developed. Further developments including analyzers and upgrading of the existing spectrometers are underway. - Highlights: • Permit to evaluate the feasibility of a polarized neutron scattering instrument prior to its implementation. • Help to understand the origin of instrumental imperfections and offer an optimized set up configuration. • Provide the possibility to use the FeSi and CoCu supermirrors, designed to polarize spin up cold neutron, to polarize thermal neutron.

  7. Design of x-ray diagnostic beam line for a synchrotron radiation source and measurement results

    Energy Technology Data Exchange (ETDEWEB)

    Garg, Akash Deep, E-mail: akash-deep@rrcat.gov.in; Karnewar, A.K.; Ojha, A.; Shrivastava, B.B.; Holikatti, A.C.; Puntambekar, T.A.; Navathe, C.P.

    2014-08-01

    Indus-2 is a 2.5 GeV synchrotron radiation source (SRS) operational at the Raja Ramanna Centre for Advanced Technology (RRCAT) in India. We have designed, developed and commissioned x-ray diagnostic beam line (X-DBL) at the Indus-2. It is based on pinhole array imaging (8–18 keV). We have derived new equations for online measurements of source position and emission angle with pinhole array optics. Measured values are compared with the measurements at an independent x-ray beam position monitor (staggered pair blade monitor) installed in the X-DBL. The measured values are close to the theoretical expected values within ±12 µm (or ±1.5 μrad) for sufficiently wide range of the beam movements. So, beside the beam size and the beam emittance, online information for the vertical position and angle is also used in the orbit steering. In this paper, the various design considerations of the X-DBL and online measurement results are presented.

  8. Computer system for the beam line data processing at JT-60 prototype neutral beam injector

    International Nuclear Information System (INIS)

    Horiike, Hiroshi; Kawai, Mikito; Ohara, Yoshihiro

    1987-08-01

    The present report describes the hard and soft wares of the data acquisition computer system for the prototype neutral injector unit for JT-60. In order to operate the unit, more than hundreds of signals of the beam line components have to be measured. These are mainly differential thermometers for the coolant waters and thermocouples for the beam dump components but not include those for the cryo system. Since the unit operates in a series of pulses, the measurement should be conducted very quickly in order to ensure the simultaneity of large number of the measured data. The present system actualize fast data acquisition using a small computer of 128 kB and measuring instruments connected through the bus. The system is connected to the JAERI computer center since the data capacity is fairly large to completely process them by the small computer. Therefore the measured data can be transferred to the computer center to calculate there, and the results can be received. After the system was completed the computer quickly print out the power flow data, which needed much work to calculate with hands. This system was very useful. It enhanced the experiments at the unit and reduced the labor. It enables us to early demonstrate the rated operation of the unit and to accurately estimate such operation data of the JT-60 NBI as the injection power. (author)

  9. Discrimination of Charged Particles in a Neutral Beam Line by Using a Solid Scintillation Detector

    Energy Technology Data Exchange (ETDEWEB)

    Woo, Jong-Kwan; Ko, Jewou; Liu, Dong [Jeju National University, Jeju (Korea, Republic of)

    2017-01-15

    In the past several decades, many studies have been conducted to search for non-baryonic dark matter, such as weakly interactive massive particles (WIMPs). In the search for WIMPs, charged particles incident on the detector are background particles because WIMPs are neutral. Charged particles originate from various sources, such as cosmic rays and laboratory materials surrounding the main detector. Therefore, a veto that discriminates charged particles can improve the particle detection efficiency of the entire experiment for detecting WIMPs. Here, we investigate in the thickness range of 1 mm to 5 mm, the optimal thickness of a polystyrene scintillator as a charged particle veto detector. We found that 3-mm-thick polystyrene provides the best performance to veto charged particles and the charged-particle background in the search for the WIMP signal. Furthermore, we fabricated 3-mm-thick and 5-mm-thick polystyrene charged particle veto detectors that will be used in an underground laboratory in the search for WIMP dark matter. After exposing those detectors are the actual beam line, we compared the rate of charged particles measured using those detectors and the rate simulated through a Monte Carlo simulation.

  10. Superconducting coil manufacturing method for low current dc beam line magnets

    International Nuclear Information System (INIS)

    Satti, J.A.

    1977-01-01

    A method of manufacturing superconducting multipole coils for 40 to 50 kG dc beam line magnets with low current is described. Small coils were built and tested successfully to short sample characteristics. The coils did not train after the first cooldown. The coils are porous and well cooled to cope with mechanical instability and energy deposited in the coil from the beam particles. The coils are wound with insulated strand cable. The cable is shaped rectangularly for winding simplicity and good tolerances. After the coil is wound, the insulated strands are electrically connected in series. This reduces the operating current and, most important, improves the coil quench propagation due to heat conduction of one strand adjacent to the other. A well distributed quench allows the magnet energy to distribute more uniformly to the copper in the superconductor wire, giving self-protected coils. A one-meter long, 43 kG, 6-inch bore tube superconducting dipole is now being fabricated. The porous coil design and coil winding methods are discussed

  11. Mechanical design and development of analyzing magnet for the RIB charge breeder beam line

    International Nuclear Information System (INIS)

    Bhattacharyya, Pranab; Ghosh, Sundeep; Bhattacharya, Mahuwa; Gupta, Anjan Dutta; Pal, Gautam; Naik, Vaishali

    2015-01-01

    An iron dominated analyzing magnet of uniform peak field 0.6 T has been developed for Radioactive Ion Beam (RIB) charge breeder beam line at VECC, Kolkata. It has two room temperature coils made of copper having channels for passage of cooling water. The other important parts of the magnet includes two yokes, two poles, vacuum chamber, view port, iron plates and the support structures. The most important properties of magnets designed and fabricated for this application is the need for high field quality. The magnet assembly has got overall dimensions of 1.1 metres x 0.91 metres x 0.63 metres and the required field uniformity is 6 x 10 -4 over pole width of ± 2.5 cm. The most critical parameter that has to be maintained to achieve the desired magnetic field is the pole gap of 80 ± 0.25 rom.This paper describes in detail about the mechanical design, coil cooling analysis, development and assembly of this magnet. (author)

  12. submitter Parametric study of transport beam lines for electron beams accelerated by laser-plasma interaction

    CERN Document Server

    Scisciò, M; Migliorati, M; Mostacci, A; Palumbo, L; Papaphilippou, Y; Antici, P

    2016-01-01

    In the last decade, laser-plasma acceleration of high-energy electrons has attracted strong attention in different fields. Electrons with maximum energies in the GeV range can be laser-accelerated within a few cm using multi-hundreds terawatt (TW) lasers, yielding to very high beam currents at the source (electron bunches with up to tens-hundreds of pC in a few fs). While initially the challenge was to increase the maximum achievable electron energy, today strong effort is put in the control and usability of these laser-generated beams that still lack of some features in order to be used for applications where currently conventional, radio-frequency (RF) based, electron beam lines represent the most common and efficient solution. Several improvements have been suggested for this purpose, some of them acting directly on the plasma source, some using beam shaping tools located downstream. Concerning the latter, several studies have suggested the use of conventional accelerator magnetic devices (such as quadrupo...

  13. Development of a polarized neutron beam line at Algerian research reactors using McStas software

    International Nuclear Information System (INIS)

    Makhloufi, M.; Salah, H.

    2017-01-01

    Unpolarized instrumentation has long been studied and designed using McStas simulation tool. But, only recently new models were developed for McStas to simulate polarized neutron scattering instruments. In the present contribution, we used McStas software to design a polarized neutron beam line, taking advantage of the available spectrometers reflectometer and diffractometer in Algeria. Both thermal and cold neutron was considered. The polarization was made by two types of supermirrors polarizers FeSi and CoCu provided by the HZB institute. For sake of performance and comparison, the polarizers were characterized and their characteristics reproduced. The simulated instruments are reported. Flipper and electromagnets for guide field are developed. Further developments including analyzers and upgrading of the existing spectrometers are underway. - Highlights: • Permit to evaluate the feasibility of a polarized neutron scattering instrument prior to its implementation. • Help to understand the origin of instrumental imperfections and offer an optimized set up configuration. • Provide the possibility to use the FeSi and CoCu supermirrors, designed to polarize spin up cold neutron, to polarize thermal neutron.

  14. Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold

    Science.gov (United States)

    Li, Yizhou; De Luca, Roberto; Cazzamalli, Samuele; Pretto, Francesca; Bajic, Davor; Scheuermann, Jörg; Neri, Dario

    2018-03-01

    In nature, specific antibodies can be generated as a result of an adaptive selection and expansion of lymphocytes with suitable protein binding properties. We attempted to mimic antibody-antigen recognition by displaying multiple chemical diversity elements on a defined macrocyclic scaffold. Encoding of the displayed combinations was achieved using distinctive DNA tags, resulting in a library size of 35,393,112. Specific binders could be isolated against a variety of proteins, including carbonic anhydrase IX, horseradish peroxidase, tankyrase 1, human serum albumin, alpha-1 acid glycoprotein, calmodulin, prostate-specific antigen and tumour necrosis factor. Similar to antibodies, the encoded display of multiple chemical elements on a constant scaffold enabled practical applications, such as fluorescence microscopy procedures or the selective in vivo delivery of payloads to tumours. Furthermore, the versatile structure of the scaffold facilitated the generation of protein-specific chemical probes, as illustrated by photo-crosslinking.

  15. High-radiance LDP source for mask inspection and beam line applications (Conference Presentation)

    Science.gov (United States)

    Teramoto, Yusuke; Santos, Bárbara; Mertens, Guido; Kops, Ralf; Kops, Margarete; von Wezyk, Alexander; Bergmann, Klaus; Yabuta, Hironobu; Nagano, Akihisa; Ashizawa, Noritaka; Taniguchi, Yuta; Yamatani, Daiki; Shirai, Takahiro; Kasama, Kunihiko

    2017-04-01

    High-throughput actinic mask inspection tools are needed as EUVL begins to enter into volume production phase. One of the key technologies to realize such inspection tools is a high-radiance EUV source of which radiance is supposed to be as high as 100 W/mm2/sr. Ushio is developing laser-assisted discharge-produced plasma (LDP) sources. Ushio's LDP source is able to provide sufficient radiance as well as cleanliness, stability and reliability. Radiance behind the debris mitigation system was confirmed to be 120 W/mm2/sr at 9 kHz and peak radiance at the plasma was increased to over 200 W/mm2/sr in the recent development which supports high-throughput, high-precision mask inspection in the current and future technology nodes. One of the unique features of Ushio's LDP source is cleanliness. Cleanliness evaluation using both grazing-incidence Ru mirrors and normal-incidence Mo/Si mirrors showed no considerable damage to the mirrors other than smooth sputtering of the surface at the pace of a few nm per Gpulse. In order to prove the system reliability, several long-term tests were performed. Data recorded during the tests was analyzed to assess two-dimensional radiance stability. In addition, several operating parameters were monitored to figure out which contributes to the radiance stability. The latest model that features a large opening angle was recently developed so that the tool can utilize a large number of debris-free photons behind the debris shield. The model was designed both for beam line application and high-throughput mask inspection application. At the time of publication, the first product is supposed to be in use at the customer site.

  16. Multiobjective optimization design of an rf gun based electron diffraction beam line

    Directory of Open Access Journals (Sweden)

    Colwyn Gulliford

    2017-03-01

    Full Text Available Multiobjective genetic algorithm optimizations of a single-shot ultrafast electron diffraction beam line comprised of a 100  MV/m 1.6-cell normal conducting rf (NCRF gun, as well as a nine-cell 2π/3 bunching cavity placed between two solenoids, have been performed. These include optimization of the normalized transverse emittance as a function of bunch charge, as well as optimization of the transverse coherence length as a function of the rms bunch length of the beam at the sample location for a fixed charge of 10^{6} electrons. Analysis of the resulting solutions is discussed in terms of the relevant scaling laws, and a detailed description of one of the resulting solutions from the coherence length optimizations is given. For a charge of 10^{6} electrons and final beam sizes of σ_{x}≥25  μm and σ_{t}≈5  fs, we found a relative coherence length of L_{c,x}/σ_{x}≈0.07 using direct optimization of the coherence length. Additionally, based on optimizations of the emittance as a function of final bunch length, we estimate the relative coherence length for bunch lengths of 30 and 100 fs to be roughly 0.1 and 0.2  nm/μm, respectively. Finally, using the scaling of the optimal emittance with bunch charge, for a charge of 10^{5} electrons, we estimate relative coherence lengths of 0.3, 0.5, and 0.92  nm/μm for final bunch lengths of 5, 30 and 100 fs, respectively.

  17. HiCoDG: A Hierarchical Data-Gathering Scheme Using Cooperative Multiple Mobile Elements

    Science.gov (United States)

    Van Le, Duc; Oh, Hoon; Yoon, Seokhoon

    2014-01-01

    In this paper, we study mobile element (ME)-based data-gathering schemes in wireless sensor networks. Due to the physical speed limits of mobile elements, the existing data-gathering schemes that use mobile elements can suffer from high data-gathering latency. In order to address this problem, this paper proposes a new hierarchical and cooperative data-gathering (HiCoDG) scheme that enables multiple mobile elements to cooperate with each other to collect and relay data. In HiCoDG, two types of mobile elements are used: the mobile collector (MC) and the mobile relay (MR). MCs collect data from sensors and forward them to the MR, which will deliver them to the sink. In this work, we also formulated an integer linear programming (ILP) optimization problem to find the optimal trajectories for MCs and the MR, such that the traveling distance of MEs is minimized. Two variants of HiCoDG, intermediate station (IS)-based and cooperative movement scheduling (CMS)-based, are proposed to facilitate cooperative data forwarding from MCs to the MR. An analytical model for estimating the average data-gathering latency in HiCoDG was also designed. Simulations were performed to compare the performance of the IS and CMS variants, as well as a multiple traveling salesman problem (mTSP)-based approach. The simulation results show that HiCoDG outperforms mTSP in terms of latency. The results also show that CMS can achieve the lowest latency with low energy consumption. PMID:25526356

  18. HiCoDG: a hierarchical data-gathering scheme using cooperative multiple mobile elements.

    Science.gov (United States)

    Van Le, Duc; Oh, Hoon; Yoon, Seokhoon

    2014-12-17

    In this paper, we study mobile element (ME)-based data-gathering schemes in wireless sensor networks. Due to the physical speed limits of mobile elements, the existing data-gathering schemes that use mobile elements can suffer from high data-gathering latency. In order to address this problem, this paper proposes a new hierarchical and cooperative data-gathering (HiCoDG) scheme that enables multiple mobile elements to cooperate with each other to collect and relay data. In HiCoDG, two types of mobile elements are used: the mobile collector (MC) and the mobile relay (MR). MCs collect data from sensors and forward them to the MR, which will deliver them to the sink. In this work, we also formulated an integer linear programming (ILP) optimization problem to find the optimal trajectories for MCs and the MR, such that the traveling distance of MEs is minimized. Two variants of HiCoDG, intermediate station (IS)-based and cooperative movement scheduling (CMS)-based, are proposed to facilitate cooperative data forwarding from MCs to the MR. An analytical model for estimating the average data-gathering latency in HiCoDG was also designed. Simulations were performed to compare the performance of the IS and CMS variants, as well as a multiple traveling salesman problem (mTSP)-based approach. The simulation results show that HiCoDG outperforms mTSP in terms of latency. The results also show that CMS can achieve the lowest latency with low energy consumption.

  19. HiCoDG: A Hierarchical Data-Gathering Scheme Using Cooperative Multiple Mobile Elements

    Directory of Open Access Journals (Sweden)

    Duc Van Le

    2014-12-01

    Full Text Available In this paper, we study mobile element (ME-based data-gathering schemes in wireless sensor networks. Due to the physical speed limits of mobile elements, the existing data-gathering schemes that usemobile elements can suffer from high data-gathering latency. In order to address this problem, this paper proposes a new hierarchical and cooperative data-gathering (HiCoDG scheme that enables multiple mobile elements to cooperate with each other to collect and relay data. In HiCoDG, two types of mobile elements are used: the mobile collector (MC and the mobile relay (MR. MCs collect data from sensors and forward them to the MR, which will deliver them to the sink. In this work, we also formulated an integer linear programming (ILP optimization problem to find the optimal trajectories for MCs and the MR, such that the traveling distance of MEs is minimized. Two variants of HiCoDG, intermediate station (IS-based and cooperative movement scheduling (CMS-based, are proposed to facilitate cooperative data forwarding from MCs to theMR. An analytical model for estimating the average data-gathering latency in HiCoDG was also designed. Simulations were performed to compare the performance of the IS and CMS variants, as well as a multiple traveling salesman problem (mTSP-based approach. The simulation results show that HiCoDG outperformsmTSP in terms of latency. The results also show that CMS can achieve the lowest latency with low energy consumption.

  20. Commissioning of a compact laser-based proton beam line for high intensity bunches around 10 MeV

    Directory of Open Access Journals (Sweden)

    S. Busold

    2014-03-01

    Full Text Available We report on the first results of experiments with a new laser-based proton beam line at the GSI accelerator facility in Darmstadt. It delivers high current bunches at proton energies around 9.6 MeV, containing more than 10^{9} particles in less than 10 ns and with tunable energy spread down to 2.7% (ΔE/E_{0} at FWHM. A target normal sheath acceleration stage serves as a proton source and a pulsed solenoid provides for beam collimation and energy selection. Finally a synchronous radio frequency (rf field is applied via a rf cavity for energy compression at a synchronous phase of -90  deg. The proton bunch is characterized at the end of the very compact beam line, only 3 m behind the laser matter interaction point, which defines the particle source.

  1. Commissioning of a compact laser-based proton beam line for high intensity bunches around 10Â MeV

    Science.gov (United States)

    Busold, S.; Schumacher, D.; Deppert, O.; Brabetz, C.; Kroll, F.; Blažević, A.; Bagnoud, V.; Roth, M.

    2014-03-01

    We report on the first results of experiments with a new laser-based proton beam line at the GSI accelerator facility in Darmstadt. It delivers high current bunches at proton energies around 9.6 MeV, containing more than 109 particles in less than 10 ns and with tunable energy spread down to 2.7% (ΔE/E0 at FWHM). A target normal sheath acceleration stage serves as a proton source and a pulsed solenoid provides for beam collimation and energy selection. Finally a synchronous radio frequency (rf) field is applied via a rf cavity for energy compression at a synchronous phase of -90 deg. The proton bunch is characterized at the end of the very compact beam line, only 3 m behind the laser matter interaction point, which defines the particle source.

  2. Experimental verification of the CLIC Decelerator with the test Beam Line in the CLIC test facility 3

    CERN Document Server

    Lillestøl, R L; Olvegård, M; Rabiller, A N; Sterbini, G; Adli, E

    2012-01-01

    The Test Beam Line in the CLIC Test Facility 3 is the first prototype of the CLIC drive beam decelerator. The main purpose of the experiment is to demonstrate efficient 12 GHz rf power production and stable transport of an electron drive beam during deceleration. The Test Beam Line consists of a FODO structure with high precision BPMs and quadrupoles mounted on mechanical movers for precisebeam alignment. Nine out of the planned 16 Power Extraction and Transfer Structures have currently been installed and commissioned. We correlate rf power production measurements with the drive beam deceleration measurements, and compare the two measurements to the theoretical predictions. We also discuss the impact of the drive beam bunch length and bunch combination on the measurements.

  3. Design and performance of an in situ high vacuum STM in beam line at 15 UD pelletron accelerator

    International Nuclear Information System (INIS)

    Singh, J.P.; Tripathi, A.; Ahuja, R.; Dutt, R.N.; Kanjilal, D.; Mehta, G.K.; Raychoudhuri, A.K.

    2000-01-01

    The design, installation and performance of an in situ high vacuum STM in the materials science beam line of 15 UD tandem Pelletron accelerator, NSC are reported. The scanning tunneling microscope (STM) has imaged highly oriented pyrolytic graphite (HOPG) surfaces with atomic resolution. Local current-voltage spectroscopy has also been performed on p-type Si (111) samples. A band gap of 1.09 ± 0.1 eV was calculated. (author)

  4. Present Status And First Results of the Final Focus Beam Line at the KEK Accelerator Test Facility

    International Nuclear Information System (INIS)

    2010-01-01

    ATF2 is a final-focus test beam line which aims to focus the low emittance beam from the ATF damping ring to a vertical size of about 37 nm and to demonstrate nanometer level beam stability. Several advanced beam diagnostics and feedback tools are used. In December 2008, construction and installation were completed and beam commissioning started, supported by an international team of Asian, European, and U.S. scientists. The present status and first results are described.

  5. Present status and first results of the final focus beam line at the KEK Accelerator Test Facility

    CERN Document Server

    Bambade, P; Amann, J; Angal-Kalinin, D; Apsimon, R; Araki, S; Aryshev, A; Bai, S; Bellomo, P; Bett, D; Blair, G; Bolzon, B; Boogert, S; Boorman, G; Burrows, P N; Christian, G; Coe, P; Constance, B; Delahaye, J P; Deacon, L; Elsen, E; Faus-Golfe, A; Fukuda, M; Gao, J; Geffroy, N; Gianfelice-Wendt, E; Guler, H; Hayano, H; Heo, A Y; Honda, Y; Huang, J Y; Hwang, W H; Iwashita, Y; Jeremie, A; Jones, J; Kamiya, Y; Karataev, P; Kim, E S; Kim, H S; Kim, S H; Komamiya, S; Kubo, K; Kume, T; Kuroda, S; Lam, B; Lyapin, A; Masuzawa, M; McCormick, D; Molloy, S; Naito, T; Nakamura, T; Nelson, J; Okamoto, D; Okugi, T; Oroku, M; Park, Y J; Parker, B; Paterson, E; Perry, C; Pivi, M; Raubenheimer, T; Renier, Y; Resta-Lopez, J; Rimbault, C; Ross, M; Sanuki, T; Scarfe, A; Schulte, D; Seryi, A; Spencer, C; Suehara, T; Sugahara, R; Swinson, C; Takahashi, T; Tauchi, T; Terunuma, N; Tomas, R; Urakawa, J; Urner, D; Verderi, M; Wang, M H; Warden, M; Wendt, M; White, G; Wittmer, W; Wolski, A; Woodley, M; Yamaguchi, Y; Yamanaka, T; Yan, Y; Yoda, H; Yokoya, K; Zhou, F; Zimmermann, F; 10.1103/PhysRevSTAB.13.042801

    2010-01-01

    ATF2 is a final-focus test beam line which aims to focus the low emittance beam from the ATF damping ring to a vertical size of about 37 nm and to demonstrate nanometer level beam stability. Several advanced beam diagnostics and feedback tools are used. In December 2008, construction and installation were completed and beam commissioning started, supported by an international team of Asian, European, and U.S. scientists. The present status and first results are described.

  6. Absolute x-ray dosimetry on a synchrotron medical beam line with a graphite calorimeter.

    Science.gov (United States)

    Harty, P D; Lye, J E; Ramanathan, G; Butler, D J; Hall, C J; Stevenson, A W; Johnston, P N

    2014-05-01

    The absolute dose rate of the Imaging and Medical Beamline (IMBL) on the Australian Synchrotron was measured with a graphite calorimeter. The calorimetry results were compared to measurements from the existing free-air chamber, to provide a robust determination of the absolute dose in the synchrotron beam and provide confidence in the first implementation of a graphite calorimeter on a synchrotron medical beam line. The graphite calorimeter has a core which rises in temperature when irradiated by the beam. A collimated x-ray beam from the synchrotron with well-defined edges was used to partially irradiate the core. Two filtration sets were used, one corresponding to an average beam energy of about 80 keV, with dose rate about 50 Gy/s, and the second filtration set corresponding to average beam energy of 90 keV, with dose rate about 20 Gy/s. The temperature rise from this beam was measured by a calibrated thermistor embedded in the core which was then converted to absorbed dose to graphite by multiplying the rise in temperature by the specific heat capacity for graphite and the ratio of cross-sectional areas of the core and beam. Conversion of the measured absorbed dose to graphite to absorbed dose to water was achieved using Monte Carlo calculations with the EGSnrc code. The air kerma measurements from the free-air chamber were converted to absorbed dose to water using the AAPM TG-61 protocol. Absolute measurements of the IMBL dose rate were made using the graphite calorimeter and compared to measurements with the free-air chamber. The measurements were at three different depths in graphite and two different filtrations. The calorimetry measurements at depths in graphite show agreement within 1% with free-air chamber measurements, when converted to absorbed dose to water. The calorimetry at the surface and free-air chamber results show agreement of order 3% when converted to absorbed dose to water. The combined standard uncertainty is 3.9%. The good agreement of

  7. X-ray diffraction using synchrotron radiation on the G.I.L.D.A. beam line at the E.S.R.F

    Energy Technology Data Exchange (ETDEWEB)

    Balerna, A [INFN, Laboratori Nazionali di Frascati, Rome (Italy); Meneghini, C [INFN, Laboratori Nazionali di Frascati, Rome (Italy); [INFM, Genoa (Italy); Bordoni, S [Rome Univ. ` Tor Vergata` (Italy). Dip. di Fisica; Mobilio, S [Rome Univ. III (Italy). Dip. di Fisica ` E. Amaldi`

    1996-09-01

    The aim of this lecture is to make a short introduction on Synchrotron radiation, its history and main properties. The main components of a synchrotron radiation beam line will be described. The Italian beam line, General purpose Italian beam line Line for Diffraction and Absorption (G.I.L.D.A.) at the European Synchrotron Radiation Facility (E.S.R.F.) in Grenoble will be used as an example. The G.I.L.D.A. diffractometer will be described in detail reporting also some experimental results.

  8. High resolution beam line of the U400M cyclotron and RIB accumulation and cooling in the K4 storage ring

    International Nuclear Information System (INIS)

    Rodin, A.M.; Sidorchuk, S.I.; Stepantsov, S.V.

    1996-01-01

    The high resolution beam line ACCULINNA put into operation on a primary beam line of the JINR U400M cyclotron is discussed in the framework of the TREBLE project. The capability of the beam line for producing radioactive ion beams is demonstrated by means of nuclear fragmentation of the primary 14 N beam, with the energy of 51 MeV · A, on the 170 mg/cm 2 carbon target. Characteristics of the obtained 6 He, 8 He and 8 B radioactive beams are presented. A scheme of accumulation and cooling on the orbit of the storage ring K4 is proposed for a low intensity radioactive beam obtained from this beam line. 8 refs., 6 figs., 1 tab

  9. Quantification of chemical elements in blood of patients affected by multiple sclerosis.

    Science.gov (United States)

    Forte, Giovanni; Visconti, Andrea; Santucci, Simone; Ghazaryan, Anna; Figà-Talamanca, Lorenzo; Cannoni, Stefania; Bocca, Beatrice; Pino, Anna; Violante, Nicola; Alimonti, Alessandro; Salvetti, Marco; Ristori, Giovanni

    2005-01-01

    Although some studies suggested a link between exposure to trace elements and development of multiple sclerosis (MS), clear information on their role in the aetiology of MS is still lacking. In this study the concentrations of Al, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn, Mo, Ni, Pb, Sb, Si, Sn, Sr, Tl, V, W, Zn and Zr were determined in the blood of 60 patients with MS and 60 controls. Quantifications were performed by inductively coupled plasma (ICP) atomic emission spectrometry and sector field ICP mass spectrometry. When the two groups were compared, an increased level of Co, Cu and Ni and a decrement of Be, Fe, Hg, Mg, Mo, Pb and Zn in blood of patients were observed. In addition, the discriminant analysis pointed out that Cu, Be, Hg, Co and Mo were able to discriminate between MS patients and controls (92.5% of cases correctly classified).

  10. Study on validation method for femur finite element model under multiple loading conditions

    Science.gov (United States)

    Guan, Fengjiao; Zhang, Guanjun; Liu, Jie; Wang, Shujing; Luo, Xu

    2018-03-01

    Acquisition of accurate and reliable constitutive parameters related to bio-tissue materials was beneficial to improve biological fidelity of a Finite Element (FE) model and predict impact damages more effectively. In this paper, a femur FE model was established under multiple loading conditions with diverse impact positions. Then, based on sequential response surface method and genetic algorithms, the material parameters identification was transformed to a multi-response optimization problem. Finally, the simulation results successfully coincided with force-displacement curves obtained by numerous experiments. Thus, computational accuracy and efficiency of the entire inverse calculation process were enhanced. This method was able to effectively reduce the computation time in the inverse process of material parameters. Meanwhile, the material parameters obtained by the proposed method achieved higher accuracy.

  11. Three-dimensional multiple reciprocity boundary element method for one-group neutron diffusion eigenvalue computations

    International Nuclear Information System (INIS)

    Itagaki, Masafumi; Sahashi, Naoki.

    1996-01-01

    The multiple reciprocity method (MRM) in conjunction with the boundary element method has been employed to solve one-group eigenvalue problems described by the three-dimensional (3-D) neutron diffusion equation. The domain integral related to the fission source is transformed into a series of boundary-only integrals, with the aid of the higher order fundamental solutions based on the spherical and the modified spherical Bessel functions. Since each degree of the higher order fundamental solutions in the 3-D cases has a singularity of order (1/r), the above series of boundary integrals requires additional terms which do not appear in the 2-D MRM formulation. The critical eigenvalue itself can be also described using only boundary integrals. Test calculations show that Wielandt's spectral shift technique guarantees rapid and stable convergence of 3-D MRM computations. (author)

  12. Present status and first results of the final focus beam line at the KEK Accelerator Test Facility

    Directory of Open Access Journals (Sweden)

    2010-04-01

    Full Text Available ATF2 is a final-focus test beam line which aims to focus the low emittance beam from the ATF damping ring to a vertical size of about 37 nm and to demonstrate nanometer level beam stability. Several advanced beam diagnostics and feedback tools are used. In December 2008, construction and installation were completed and beam commissioning started, supported by an international team of Asian, European, and U.S. scientists. The present status and first results are described.

  13. Multiple nano elements of SCC--transition from phenomenology to predictive mechanistics

    International Nuclear Information System (INIS)

    Staehle, R.W.

    2009-01-01

    Full text of publication follows: Predicting the occurrence and rate of stress corrosion cracking in materials of construction is one of the most critical pathways for assuring the reliability of light water nuclear reactor plants. It is the general intention of operators of nuclear plants that they continue performing satisfactorily for times of 60 to 80 years at least. Such times are beyond existing experience, and there are no bases for choosing credible predictions. Present bases for predicting SCC rely on anecdotal experience for predicting what materials sustain SCC in specified environments and on phenomenological correlations using such parameters as K (stress intensity), 1/T (temperature), E(corr) (corrosion potential), pH, [x] a (concentration), other established quantities, and statistical correlations. While these phenomenological correlations have served the industry well in the past, they have also allowed grievous mistakes. Further, such correlations are flawed in their fundamental credibility. Predicting SCC in aqueous solutions means to predict its dependence upon the seven primary variables: potential, pH, species, alloy composition, alloy structure, stress and temperature. A serious prediction of SCC upon these seven primary variables can only be achieved by moving to fundamental nano elements. Unfortunately, useful predictability from the nano approach cannot be achieved quickly or easily; thus, it will continue to be necessary to rely on existing phenomenology. However, as the nano approach evolves, it can contribute increasingly to the quantitative capacity of the phenomenological approach. The nano approach will require quite different talents and thinking than are now applied to the prediction of SCC; while some of the boundary conditions of phenomenology must continue to be applied, elements of the nano approach will include accounting for at least, typically, the following multiple elements as they apply at the sites of initiation and at

  14. Element-specific spectral imaging of multiple contrast agents: a phantom study

    Science.gov (United States)

    Panta, R. K.; Bell, S. T.; Healy, J. L.; Aamir, R.; Bateman, C. J.; Moghiseh, M.; Butler, A. P. H.; Anderson, N. G.

    2018-02-01

    This work demonstrates the feasibility of simultaneous discrimination of multiple contrast agents based on their element-specific and energy-dependent X-ray attenuation properties using a pre-clinical photon-counting spectral CT. We used a photon-counting based pre-clinical spectral CT scanner with four energy thresholds to measure the X-ray attenuation properties of various concentrations of iodine (9, 18 and 36 mg/ml), gadolinium (2, 4 and 8 mg/ml) and gold (2, 4 and 8 mg/ml) based contrast agents, calcium chloride (140 and 280 mg/ml) and water. We evaluated the spectral imaging performances of different energy threshold schemes between 25 to 82 keV at 118 kVp, based on K-factor and signal-to-noise ratio and ranked them. K-factor was defined as the X-ray attenuation in the K-edge containing energy range divided by the X-ray attenuation in the preceding energy range, expressed as a percentage. We evaluated the effectiveness of the optimised energy selection to discriminate all three contrast agents in a phantom of 33 mm diameter. A photon-counting spectral CT using four energy thresholds of 27, 33, 49 and 81 keV at 118 kVp simultaneously discriminated three contrast agents based on iodine, gadolinium and gold at various concentrations using their K-edge and energy-dependent X-ray attenuation features in a single scan. A ranking method to evaluate spectral imaging performance enabled energy thresholds to be optimised to discriminate iodine, gadolinium and gold contrast agents in a single spectral CT scan. Simultaneous discrimination of multiple contrast agents in a single scan is likely to open up new possibilities of improving the accuracy of disease diagnosis by simultaneously imaging multiple bio-markers each labelled with a nano-contrast agent.

  15. Overview of the Conceptual Design of the Future VENUS Neutron Imaging Beam Line at the Spallation Neutron Source

    Science.gov (United States)

    Bilheux, Hassina; Herwig, Ken; Keener, Scott; Davis, Larry

    VENUS (Versatile Neutron Imaging Beam line at the Spallation Neutron Source) will be a world-class neutron-imaging instrument that will uniquely utilize the Spallation Neutron Source (SNS) time-of-flight (TOF) capabilities to measure and characterize objects across several length scales (mm to μm). When completed, VENUS will provide academia, industry and government laboratories with the opportunity to advance scientific research in areas such as energy, materials, additive manufacturing, geosciences, transportation, engineering, plant physiology, biology, etc. It is anticipated that a good portion of the VENUS user community will have a strong engineering/industrial research focus. Installed at Beam line 10 (BL10), VENUS will be a 25-m neutron imaging facility with the capability to fully illuminate (i.e., umbra illumination) a 20 cm x 20 cm detector area. The design allows for a 28 cm x 28 cm field of view when using the penumbra to 80% of the full illumination flux. A sample position at 20 m will be implemented for magnification measurements. The optical components are comprised of a series of selected apertures, T0 and bandwidth choppers, beam scrapers, a fast shutter to limit sample activation, and flight tubes filled with Helium. Techniques such as energy selective, Bragg edge and epithermal imaging will be available at VENUS.

  16. On the distribution of trace element concentrations in multiple bone elements in 10 Danish medieval and post-medieval individuals.

    Science.gov (United States)

    Lund Rasmussen, Kaare; Skytte, Lilian; D'imporzano, Paolo; Orla Thomsen, Per; Søvsø, Morten; Lier Boldsen, Jesper

    2017-01-01

    The differences in trace element concentrations among 19 different bone elements procured from 10 archaeologically derived human skeletons have been investigated. The 10 individuals are dated archaeologically and some by radiocarbon dating to the medieval and post-medieval period, an interval from ca. AD 1150 to ca. AD 1810. This study is relevant for two reasons. First, most archaeometric studies analyze only one bone sample from each individual; so to what degree are the bones in the human body equal in trace element chemistry? Second, differences in turnover time of the bone elements makes the cortical tissues record the trace element concentrations in equilibrium with the blood stream over a longer time earlier in life than the trabecular. Therefore, any differences in trace element concentrations between the bone elements can yield what can be termed a chemical life history of the individual, revealing changes in diet, provenance, or medication throughout life. Thorough decontamination and strict exclusion of non-viable data has secured a dataset of high quality. The measurements were carried out using Inductively Coupled Plasma Mass Spectrometry (for Fe, Mn, Al, Ca, Mg, Na, Ba, Sr, Zn, Pb and As) and Cold Vapor Atomic Absorption Spectroscopy (for Hg) on ca. 20 mg samples. Twelve major and trace elements have been measured on 19 bone elements from 10 different individuals interred at five cemeteries widely distributed in medieval and renaissance Denmark. The ranges of the concentrations of elements were: Na (2240-5660 µg g -1 ), Mg (440-2490 µg g -1 ), Al (9-2030 µg g -1 ), Ca (22-36 wt. %), Mn (5-11450 µg g -1 ), Fe (32-41850 µg g -1 ), Zn (69-2610 µg g -1 ), As (0.4-120 µg g -1 ), Sr (101-815 µg g -1 ), Ba (8-880 µg g -1 ), Hg (7-78730 ng g -1 ), and Pb (0.8-426 µg g -1 ). It is found that excess As is mainly of diagenetic origin. The results support that Ba and Sr concentrations are effective provenance or dietary indicators. Migrating

  17. Multi-Target Angle Tracking Algorithm for Bistatic Multiple-Input Multiple-Output (MIMO Radar Based on the Elements of the Covariance Matrix

    Directory of Open Access Journals (Sweden)

    Zhengyan Zhang

    2018-03-01

    Full Text Available In this paper, we consider the problem of tracking the direction of arrivals (DOA and the direction of departure (DOD of multiple targets for bistatic multiple-input multiple-output (MIMO radar. A high-precision tracking algorithm for target angle is proposed. First, the linear relationship between the covariance matrix difference and the angle difference of the adjacent moment was obtained through three approximate relations. Then, the proposed algorithm obtained the relationship between the elements in the covariance matrix difference. On this basis, the performance of the algorithm was improved by averaging the covariance matrix element. Finally, the least square method was used to estimate the DOD and DOA. The algorithm realized the automatic correlation of the angle and provided better performance when compared with the adaptive asymmetric joint diagonalization (AAJD algorithm. The simulation results demonstrated the effectiveness of the proposed algorithm. The algorithm provides the technical support for the practical application of MIMO radar.

  18. Multi-Target Angle Tracking Algorithm for Bistatic Multiple-Input Multiple-Output (MIMO) Radar Based on the Elements of the Covariance Matrix.

    Science.gov (United States)

    Zhang, Zhengyan; Zhang, Jianyun; Zhou, Qingsong; Li, Xiaobo

    2018-03-07

    In this paper, we consider the problem of tracking the direction of arrivals (DOA) and the direction of departure (DOD) of multiple targets for bistatic multiple-input multiple-output (MIMO) radar. A high-precision tracking algorithm for target angle is proposed. First, the linear relationship between the covariance matrix difference and the angle difference of the adjacent moment was obtained through three approximate relations. Then, the proposed algorithm obtained the relationship between the elements in the covariance matrix difference. On this basis, the performance of the algorithm was improved by averaging the covariance matrix element. Finally, the least square method was used to estimate the DOD and DOA. The algorithm realized the automatic correlation of the angle and provided better performance when compared with the adaptive asymmetric joint diagonalization (AAJD) algorithm. The simulation results demonstrated the effectiveness of the proposed algorithm. The algorithm provides the technical support for the practical application of MIMO radar.

  19. Detailed assessment of gene activation levels by multiple hypoxia-responsive elements under various hypoxic conditions.

    Science.gov (United States)

    Takeuchi, Yasuto; Inubushi, Masayuki; Jin, Yong-Nan; Murai, Chika; Tsuji, Atsushi B; Hata, Hironobu; Kitagawa, Yoshimasa; Saga, Tsuneo

    2014-12-01

    HIF-1/HRE pathway is a promising target for the imaging and the treatment of intractable malignancy (HIF-1; hypoxia-inducible factor 1, HRE; hypoxia-responsive element). The purposes of our study are: (1) to assess the gene activation levels resulting from various numbers of HREs under various hypoxic conditions, (2) to evaluate the bidirectional activity of multiple HREs, and (3) to confirm whether multiple HREs can induce gene expression in vivo. Human colon carcinoma HCT116 cells were transiently transfected by the constructs containing a firefly luciferase reporter gene and various numbers (2, 4, 6, 8, 10, and 12) of HREs (nHRE+, nHRE-). The relative luciferase activities were measured under various durations of hypoxia (6, 12, 18, and 24 h), O2 concentrations (1, 2, 4, 8, and 16 %), and various concentrations of deferoxamine mesylate (20, 40, 80, 160, and 320 µg/mL growth medium). The bidirectional gene activation levels by HREs were examined in the constructs (dual-luc-nHREs) containing firefly and Renilla luciferase reporter genes at each side of nHREs. Finally, to test whether the construct containing 12HRE and the NIS reporter gene (12HRE-NIS) can induce gene expression in vivo, SPECT imaging was performed in a mouse xenograft model. (1) gene activation levels by HREs tended to increase with increasing HRE copy number, but a saturation effect was observed in constructs with more than 6 or 8 copies of an HRE, (2) gene activation levels by HREs increased remarkably during 6-12 h of hypoxia, but not beyond 12 h, (3) gene activation levels by HREs decreased with increasing O2 concentrations, but could be detected even under mild hypoxia at 16 % O2, (4) the bidirectionally proportional activity of the HRE was confirmed regardless of the hypoxic severity, and (5) NIS expression driven by 12 tandem copies of an HRE in response to hypoxia could be visualized on in vivo SPECT imaging. The results of this study will help in the understanding and assessment of

  20. Development of a New RF Finger concept for vacuum beam line interconnections

    CERN Document Server

    Garion, C; Rambeau, H

    2012-01-01

    RF contact fingers are primarily used as a transition element to absorb the thermal expansion of vacuum chambers during bake-out and also to compensate for mechanical tolerances. They have to carry the beam image current to avoid the generation of Higher Order Modes and to reduce beam impedances. They are usually made out of copper beryllium thin sheets and are therefore very fragile and critical components. In this paper, a robust design based on a deformable finger concept is proposed. It allows the compensation of large longitudinal movements and also defaults such as transverse offset, twist or bending. The concept of this new RF fingers is first explained, then the design of the component is presented. The mechanical study based on a highly non-linear Finite Element model is shown as well as preliminary tests, including fatigue assessment, carried out on prototypes.

  1. An automatic beam steering system for the NSLS X-17T beam line using closed orbit feedback

    International Nuclear Information System (INIS)

    Nawrocky, R.J.; Ma, Li; Rarback, H.M.; Singh, O.V.; Yu, L.H.

    1987-01-01

    Initial observations of motion of the undulator radiation in the NSLS X-17T beam line clearly indicated that the beam had to be stabilized in both directions to be usable for the planned soft x-ray imaging experiments. The low frequency spectra of beam motion contained peaks in the range from dc to 60 Hz and at higher frequencies. A beam steering system employing closed orbit feedback has been designed and installed to stabilize the beam in both planes. In each plane of motion, beam position is measured with a beam position detector and a correction signal is fed back to a local four magnet orbit bump to dynamically control the angle of the radiation at the source. This paper describes the design and performance of the beam steering system

  2. Simulations of the BNL/SLAC/UCLA 1.6 cell emittance compensated photocathode RF gun low energy beam line

    International Nuclear Information System (INIS)

    Palmer, D.T.; Miller, R.H.; Winick, H.

    1995-01-01

    A dedicated low energy (2 to 10 MeV) experimental beam line is now under construction at Brookhaven National Laboratories Accelerator Test Facility (BNL/ATF) for photocathode RF gun testing and photoemission experiments. The design of the experimental line, using the 1.6 cell photocathode RF gun developed by the BNL/SLAC/UCLA RF gun collaboration is presented. Detailed beam dynamics simulations were performed for the 1.6 cell RF gun injector using a solenoidal emittance compensation technique. An experimental program for testing the 1.6 cell RF gun is presented. This program includes beam loading caused by dark current, higher order mode field measurements, integrated and slice emittance measurements using a pepper-pot and RF kicker cavity

  3. Design and Construction of a Beam Position Monitor Prototype for the Test Beam Line of the CTF3

    CERN Document Server

    Garcia Garrigos, Juan Jose

    2008-01-01

    A prototype of Beam Position Monitor (BPM) for the Test Beam Line (TBL) of the 3rd CLIC Test Facility (CTF3) at CERN has been designed and constructed at IFIC in collaboration with the CERN CTF3 team. The design is a scaled version of the BPMs of the CTF3 linac. The design goals are a resolution of 5 μm, an overall precision of 50 μm, in a circular vacuum chamber of 24 mm, in a frequency bandwidth between 10 kHz and 100MHz.The BPMis an inductive type BPM. Beam positions are derived from the image current created by a high frequency electron bunch beam into four electrodes surrounding the vacuum chamber. In this work we describe the mechanical design and construction, the description of the associated electronics together with the first calibration measurements performed in a wire test bench at CERN.

  4. A directly cooled grating substrate for ALS [Advanced Light Source] undulator beam lines

    International Nuclear Information System (INIS)

    DiGennaro, R.; Swain, T.

    1989-08-01

    Design analyses using finite element methods are presented for thermal distortion of water-cooled diffraction grating substrates for a potential application at the LBL Advanced Light Source, demonstrating that refinements in cooling channel configuration and heat flux distribution can significantly reduce optical surface distortion with high heat loads. Using an existing grating substrate design, sensitivity of tangential slope errors due to thermal distortion is evaluated for a variety of thermal boundary conditions, including coolant flow rate and heat transfer film coefficients, surface illumination area and heat distribution profile, and location of the convection cooling surfaces adjacent to the heated region. 1 ref., 5 figs., 2 tabs

  5. Status of the SPES-charge breeder (SPES-CB) and its beam line at INFN-LNL

    International Nuclear Information System (INIS)

    Galatá, Àlessio; Comunian, M.; Bellan, L.; Maggiore, M.; Patti, G.; Roncolato, C.; Bisoffi, G.; Russo, A.D.; Calabretta, L.; Angot, J.; Lamy, T.

    2016-01-01

    The Selective Production of Exotic Species (SPES) facility is under construction at INFN-LNL: aim of this project is the production, ionization and post-acceleration of radioactive ions to perform forefront research in nuclear physics. Radioactive species will be produced by fissions induced by a proton beam impinging on an UC_x target: the proton beam will be delivered by a room temperature cyclotron (built by the Best Company) with a maximum energy of 40 MeV and 0.25 mA of maximum current. The radioactive species produced in the Target-Ion-Source system, extracted as a 1+ beam, cooled in a RFQ-cooler and purified from the isobars contaminants through a High Resolution Mass Spectrometer (HRMS). In order to allow post acceleration with the superconducting linac ALPI at INFN-LNL (up to 10 MeV/A for A/q = 7), an ECR-based charge breeding technique (ECR-CB) was chosen: in particular the SPES-CB was developed by the LPSC Grenoble on the basis of the Phoenix booster. The SPES-CB will be equipped with a complete test bench, totally integrated with the SPES beam line: in particular, in order to avoid beam contaminations induced by the impurities present inside the SPES-CB, and to have high transmission for a beam of very low intensity, special attention was paid not only to the transport efficiency but also to the resolution of the spectrometer downstream the charge breeder, with the design of a Medium Resolution Mass Spectrometer (MRMS). In the following paper the technical aspects connected with SPES-CB, its beam line and the transport of highly charged radioactive ions will be described.

  6. High intensity proton beam transportation through fringe field of 70 MeV compact cyclotron to beam line targets

    Science.gov (United States)

    Zhang, Xu; Li, Ming; Wei, Sumin; Xing, Jiansheng; Hu, Yueming; Johnson, Richard R.; Piazza, Leandro; Ryjkov, Vladimir

    2016-06-01

    From the stripping points, the high intensity proton beam of a compact cyclotron travels through the fringe field area of the machine to the combination magnet. Starting from there the beams with various energy is transferred to the switching magnet for distribution to the beam line targets. In the design of the extraction and transport system for the compact proton cyclotron facilities, such as the 70 MeV in France and the 100 MeV in China, the space charge effect as the beam crosses the fringe field has not been previously considered; neither has the impact on transverse beam envelope coupled from the longitudinal direction. Those have been concerned much more with the higher beam-power because of the beam loss problem. In this paper, based on the mapping data of 70 MeV cyclotron including the fringe field by BEST Cyclotron Inc (BEST) and combination magnet field by China Institute of Atomic Energy (CIAE), the beam extraction and transport are investigated for the 70 MeV cyclotron used on the SPES project at Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro (INFN-LNL). The study includes the space charge effect and longitudinal and transverse coupling mentioned above, as well as the matching of beam optics using the beam line for medical isotope production as an example. In addition, the designs of the ±45° switching magnets and the 60° bending magnet for the extracted beam with the energy from 35 MeV to 70 MeV have been made. Parts of the construction and field measurements of those magnets have been done as well. The current result shows that, the design considers the complexity of the compact cyclotron extraction area and fits the requirements of the extraction and transport for high intensity proton beam, especially at mA intensity levels.

  7. Status of the SPES-charge breeder (SPES-CB) and its beam line at INFN-LNL

    Energy Technology Data Exchange (ETDEWEB)

    Galatá, Àlessio; Comunian, M. [INFN-Laboratori Nazionali di Legnaro, Viale dell’Universitá 2, 35020 Legnaro, Padova (Italy); Bellan, L. [INFN-Laboratori Nazionali di Legnaro, Viale dell’Universitá 2, 35020 Legnaro, Padova (Italy); Dipartimento di Fisica e Astronomia, Universitá degli Studi di Padova e Sezione INFN, Padova (Padova) (Italy); Maggiore, M.; Patti, G.; Roncolato, C.; Bisoffi, G. [INFN-Laboratori Nazionali di Legnaro, Viale dell’Universitá 2, 35020 Legnaro, Padova (Italy); Russo, A.D.; Calabretta, L. [INFN-Laboratori Nazionali del Sud, via S. Sofia 62, 95123 Catania (Italy); Angot, J.; Lamy, T. [LPSC – Université Grenoble Alpes – CNRS/IN2P3, 53 rue des Martyrs, 38026 Grenoble Cedex (France)

    2016-06-01

    The Selective Production of Exotic Species (SPES) facility is under construction at INFN-LNL: aim of this project is the production, ionization and post-acceleration of radioactive ions to perform forefront research in nuclear physics. Radioactive species will be produced by fissions induced by a proton beam impinging on an UC{sub x} target: the proton beam will be delivered by a room temperature cyclotron (built by the Best Company) with a maximum energy of 40 MeV and 0.25 mA of maximum current. The radioactive species produced in the Target-Ion-Source system, extracted as a 1+ beam, cooled in a RFQ-cooler and purified from the isobars contaminants through a High Resolution Mass Spectrometer (HRMS). In order to allow post acceleration with the superconducting linac ALPI at INFN-LNL (up to 10 MeV/A for A/q = 7), an ECR-based charge breeding technique (ECR-CB) was chosen: in particular the SPES-CB was developed by the LPSC Grenoble on the basis of the Phoenix booster. The SPES-CB will be equipped with a complete test bench, totally integrated with the SPES beam line: in particular, in order to avoid beam contaminations induced by the impurities present inside the SPES-CB, and to have high transmission for a beam of very low intensity, special attention was paid not only to the transport efficiency but also to the resolution of the spectrometer downstream the charge breeder, with the design of a Medium Resolution Mass Spectrometer (MRMS). In the following paper the technical aspects connected with SPES-CB, its beam line and the transport of highly charged radioactive ions will be described.

  8. High intensity proton beam transportation through fringe field of 70 MeV compact cyclotron to beam line targets

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xu, E-mail: emmazhang103@gmail.com [China Institute of Atomic Energy (China); Li, Ming; Wei, Sumin; Xing, Jiansheng; Hu, Yueming [China Institute of Atomic Energy (China); Johnson, Richard R.; Piazza, Leandro; Ryjkov, Vladimir [BEST Cyclotron Inc (Canada)

    2016-06-01

    From the stripping points, the high intensity proton beam of a compact cyclotron travels through the fringe field area of the machine to the combination magnet. Starting from there the beams with various energy is transferred to the switching magnet for distribution to the beam line targets. In the design of the extraction and transport system for the compact proton cyclotron facilities, such as the 70 MeV in France and the 100 MeV in China, the space charge effect as the beam crosses the fringe field has not been previously considered; neither has the impact on transverse beam envelope coupled from the longitudinal direction. Those have been concerned much more with the higher beam-power because of the beam loss problem. In this paper, based on the mapping data of 70 MeV cyclotron including the fringe field by BEST Cyclotron Inc (BEST) and combination magnet field by China Institute of Atomic Energy (CIAE), the beam extraction and transport are investigated for the 70 MeV cyclotron used on the SPES project at Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro (INFN–LNL). The study includes the space charge effect and longitudinal and transverse coupling mentioned above, as well as the matching of beam optics using the beam line for medical isotope production as an example. In addition, the designs of the ±45° switching magnets and the 60° bending magnet for the extracted beam with the energy from 35 MeV to 70 MeV have been made. Parts of the construction and field measurements of those magnets have been done as well. The current result shows that, the design considers the complexity of the compact cyclotron extraction area and fits the requirements of the extraction and transport for high intensity proton beam, especially at mA intensity levels.

  9. A numerical comparison between the multiple-scales and finite-element solution for sound propagation in lined flow ducts

    NARCIS (Netherlands)

    Rienstra, S.W.; Eversman, W.

    2001-01-01

    An explicit, analytical, multiple-scales solution for modal sound transmission through slowly varying ducts with mean flow and acoustic lining is tested against a numerical finite-element solution solving the same potential flow equations. The test geometry taken is representative of a high-bypass

  10. A high-energy double-crystal fixed exit monochromator for the X17 superconducting wiggler beam line at the NSLS

    International Nuclear Information System (INIS)

    Garrett, R.F.; Dilmanian, F.A.; Oversluizen, T.; Lenhard, A.; Berman, L.E.; Chapman, L.D.; Stoeber, W.

    1992-01-01

    A high-energy double-crystal x-ray monochromator has been constructed for use on the X-17 beam line at the National Synchrotron Light Source (NSLS). Its design is based on the ''boomerang'' right angle linkage, and features a fixed exit beam, a cooled first crystal, and an energy range of 8--92 keV. The entire mechanism is UHV compatible. The design is described and performance details, obtained in testing at the X17 beam line, are presented

  11. The transmission theory of electrostatic analyzer in six dimensional phase space and the concept design of a supersensitive mass spectrometer beam line for HI-13 tandem accelerator

    International Nuclear Information System (INIS)

    Guan Xialing; Cao Qingxi; Zhang Jie; Ye Jingping

    1986-01-01

    It follows from the motion equations of charged particle in curvilinear coordinates system that the transfer matrix of electrostatic analyzer was derived in six dimensional phase space. In accordance with these matrixes, the concept design of the supersensitive mass spectrometer beam line for HI-13 tandem accelerator was calculated

  12. Experimental Observations of In-Situ Secondary Electron Yield Reduction in the PEP-II Particle Accelerator Beam Line

    International Nuclear Information System (INIS)

    Pivi, Mauro

    2010-01-01

    Beam instability caused by the electron cloud has been observed in positron and proton storage rings and it is expected to be a limiting factor in the performance of the positron Damping Ring (DR) of future Linear Colliders (LC) such as ILC and CLIC. To test a series of promising possible electron cloud mitigation techniques as surface coatings and grooves, in the Positron Low Energy Ring (LER) of the PEP-II accelerator, we have installed several test vacuum chambers including (i) a special chamber to monitor the variation of the secondary electron yield of technical surface materials and coatings under the effect of ion, electron and photon conditioning in situ in the beam line; (ii) chambers with grooves in a straight magnetic-free section; and (iii) coated chambers in a dedicated newly installed 4-magnet chicane to study mitigations in a magnetic field region. In this paper, we describe the ongoing R and D effort to mitigate the electron cloud effect for the LC damping ring, focusing on the first experimental area and on results of the reduction of the secondary electron yield due to in situ conditioning.

  13. Secondary Electron Yield Measurements and Groove Chambers Tests in the PEP-II Beam Line Straights Sections

    International Nuclear Information System (INIS)

    Pivi, M

    2008-01-01

    Beam instability caused by the electron cloud has been observed in positron and proton storage rings and it is expected to be a limiting factor in the performance of the positron Damping Ring (DR) of future Linear Colliders such as ILC and CLIC [1, 2]. In the Positron Low Energy Ring (LER) of the PEP-II accelerator, we have installed vacuum chambers with rectangular grooves in a straight magnetic-free section to test this promising possible electron cloud mitigation technique. We have also installed a special chamber to monitor the secondary electron yield of TiN and TiZrV (NEG) coating, Copper, Stainless Steel and Aluminum under the effect of electron and photon conditioning in situ in the beam line. In this paper, we describe the ongoing R and D effort to mitigate the electron cloud effect for the ILC damping ring, the latest results on in situ secondary electron yield conditioning and recent update on the groove tests in PEP-II

  14. Design of UHV chamber assembly and mirror mounts for high resolution VUV beam line at INDUS-1

    International Nuclear Information System (INIS)

    Saksena, G.D.; Sinha, A.K.; Bhattacharya, S.S.

    1993-01-01

    The reflecting optical system is designed for the high resolution VUV spectroscopy facility to be installed at INDUS-1. The fore-optics system consists of three cylindrical mirrors (M1, M2 and M3) to accept a 60 mrad (horizontal) x 6 mrad (vertical) diverging synchrotron beam from the storage ring in order to focus the image on the entrance slit of the vacuum spectrometer located at 13 m from the source point. In this paper we present some important details regarding mechanical design of the high resolution beam line consisting of mirror mounts, UHV chambers, associated mechanisms and beam pipes. The mirrors are mounted in an adjustable three point kinematic holder. In addition, these mounts are provided with a multi-plane alignment provision. Mirror mounts are placed inside VHV chambers which are provided with three translational and two rotational movements to facilitate initial as well as final on-line fine-tuned alignments. Beam pipes are connected to the VHV chambers through flanged bellows. Chambers, associated mechanisms, beam pipes with its non-rigid support and related pumping stations are positioned in the support structure rigidly. (author). 2 figs

  15. The MICE Muon Beam on ISIS and the beam-line instrumentation of the Muon Ionization Cooling Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Bogomilov, M. [University of Sofia (Bulgaria); et al.

    2012-05-01

    The international Muon Ionization Cooling Experiment (MICE), which is under construction at the Rutherford Appleton Laboratory (RAL), will demonstrate the principle of ionization cooling as a technique for the reduction of the phase-space volume occupied by a muon beam. Ionization cooling channels are required for the Neutrino Factory and the Muon Collider. MICE will evaluate in detail the performance of a single lattice cell of the Feasibility Study 2 cooling channel. The MICE Muon Beam has been constructed at the ISIS synchrotron at RAL, and in MICE Step I, it has been characterized using the MICE beam-instrumentation system. In this paper, the MICE Muon Beam and beam-line instrumentation are described. The muon rate is presented as a function of the beam loss generated by the MICE target dipping into the ISIS proton beam. For a 1 V signal from the ISIS beam-loss monitors downstream of our target we obtain a 30 KHz instantaneous muon rate, with a neglible pion contamination in the beam.

  16. Comparison of oxidation resistance of copper treated by beam-line ion implantation and plasma immersion ion implantation

    International Nuclear Information System (INIS)

    An Quanzhang; Li Liuhe; Hu Tao; Xin Yunchang; Fu, Ricky K.Y.; Kwok, D.T.K.; Cai Xun; Chu, Paul K.

    2009-01-01

    Copper which has many favorable properties such as low cost, high thermal and electrical conductivity, as well as easy fabrication and joining is one of the main materials in lead frames, interconnects, and foils in flexible circuits. Furthermore, copper is one of the best antibacterial materials. However, unlike aluminum oxide or chromium oxide, the surface copper oxide layer does not render sufficient protection against oxidation. In this work, in order to improve the surface oxidation resistance of Cu, Al and N were introduced into copper by plasma immersion ion implantation (PIII) and beam-line ion implantation (BII). The implantation fluences of Al and N were 2 x 10 17 ions cm -2 and 5 x 10 16 ions cm -2 , respectively. The implanted and untreated copper samples were oxidized in air at 260 deg. C for 1 h. The X-ray diffraction (XRD), scanning electron microscopy (SEM), as well as X-ray photoelectron spectroscopy (XPS) results indicate that both implantation methods can enhance the oxidation resistance of copper but to different extent. PIII is superior to BII in enhancing the oxidation resistance of copper. The effects and possible mechanisms are discussed.

  17. Design study of the ESS-Bilbao 50 MeV proton beam line for radiobiological studies

    Energy Technology Data Exchange (ETDEWEB)

    Huerta-Parajon, M., E-mail: mhuerta@essbilbao.org; Martinez-Ballarin, R., E-mail: rmartinez@essbilbao.org; Abad, E., E-mail: eabad@essbilbao.org

    2015-02-01

    The ESS-Bilbao proton accelerator facility has been designed fulfilling the European Spallation Source (ESS) specifications to serve as the Spanish contribution to the ESS construction. Furthermore, several applications of the ESS-Bilbao proton beam are being considered in order to contribute to the knowledge in the field of radiobiology, materials and aerospace components. Understanding of the interaction of radiation with biological systems is of vital importance as it affects important applications such as cancer treatment with ion beam therapy among others. ESS-Bilbao plans to house a facility exclusively dedicated to radiobiological experiments with protons up to 50 MeV. Beam line design, optimisation and initial calculations of flux densities and absorbed doses were undertaken using the Monte Carlo simulation package FLUKA. A proton beam with a flux density of about 10{sup 6} protons/cm{sup 2} s reaches the water sample with a flat lateral distribution of the dose. The absorbed dose at the pristine Bragg peak calculated with FLUKA is 2.4 ± 0.1 Gy in 1 min of irradiation time. This value agrees with the clinically meaningful dose rates, i.e. around 2 Gy/min, used in hadrontherapy. Optimisation and validation studies in the ESS-Bilbao line for radiobiological experiments are detailed in this article.

  18. Project for a beam line consecrated to soft condensed matter, common heterogeneous materials and non-crystalline materials on soleil

    International Nuclear Information System (INIS)

    Ne, F.; Zemb, T.

    1998-01-01

    This project is a part of the 'SOLEIL' synchrotron project. The camera proposed is optimized for small angle x-ray scattering in the domain of soft condensed matter, common heterogeneous materials such as wood, cements, glass, and more generally non-crystalline materials. The beam line is designed to allow a quick succession of different users without time consuming adjustments. Therefore, optical settings are minimized, taking into account the pluri-disciplinary nature of the analysis possibilities. To this end, the technical requirements are as follows. First and essentially, the wave-length has to be fixed and set around 12 keV. Focusing mirrors, optics to sample and sample to detector distances, and the size of the detector allow for a wide range of wave vector to be used. Rejection rate will be lower, and angular dynamical range will be larger than any of the current synchrotron lines. We want this line to be, and to stay, complementary to more specific systems, such as reflectivity experiments or grazing angle scattering experiments. However, we are thinking of an adaptation to ultra small angle scattering mode, based on the Bonse and Hart camera. Such equipment, actually a kind of 'Instamatic' of the reciprocal space, will fulfill to the need of chemical engineers, biophysicists or material scientists interested in hard as well as soft condensed matter. It will allow a large amount of experiments per time unit. (author)

  19. Guidelines for remote handling maintenance of ITER neutral beam line components: Proposal of an alternate supporting system

    International Nuclear Information System (INIS)

    Cordier, J.J.; Bayetti, P.; Hemsworth, R.; David, O.; Friconneau, J.P.

    2007-01-01

    Remote handling (R/H) maintenance of ITER components is one of the main challenges of the ITER project. This type of maintenance shall be operational for the assembly and nuclear phase of exploitation of ITER. It must be considered at a very early stage since it significantly impacts on the components design, interfaces management, assembly, maintenance and integration aspects. A large part of the R/H equipment will be procured by the EU Participating Team, including the whole Neutral Beam R/H Equipment. The Neutral Beam Heating and Current Drive system (NB and CD) design is being revisited by the ITER project. A vertical maintenance scheme is presently considered which may significantly impact on the reference design and associated components and lead to a new design of the NB and CD vacuum tank. In addition, NB line components remote handling solutions are being studied. The neutral beam test facility ITER to be built in Europe in the near future is also based on the vertical NB maintenance scheme of beam line components. New design guidelines compliant for both the ITER NB and CD system and the NB test facility proposed by the CEA association are described in the paper

  20. Tertiary particle production and target optimization of the H2 beam line in the SPS North Area

    CERN Document Server

    AUTHOR|(CDS)2079540; Tellander, Felix; CERN. Geneva. ATS Department

    2016-01-01

    In this note, the tertiary particle yield from secondary targets of different materials placed at the ‘filter’ position of the H2 beam line of SPS North Area are presented. The production is studied for secondary beams of different momenta in the range of 50-250 GeV/c. More specifically, we studied six different targets: two copper cylinders with a radius of 40 mm and lengths of 100 and 300 mm, one solid tungsten cylinder with a radius of 40 mm and a length of 150 mm and three polyethylene cylinders with radius of 40 mm and lengths of 550, 700 and 1000 mm. Eight different momenta of the secondary beam (50, 60, 70, 100, 120, 150, 200 and 250 GeV/c) as well as two different physics lists (QGSP_BIC and FTFP_BERT) have been extensively studied. The purpose of this study is (a) to optimize (using the appropriate filter target) the particle production from the secondary targets as demanded by the experiments (b) investigate the proton production (with respect to the pion production) in the produced tertiary bea...

  1. Laser Plasma Instability (LPI) Driven Light Scattering Measurements with 44 beam-lines of Nike KrF Laser^*

    Science.gov (United States)

    Oh, J.; Weaver, J. L.; Kehne, D. M.; Phillips, L. S.; Obenschain, S. P.; Serlin, V.; McLean, E. A.; Lehmberg, R. H.; Manka, C. K.

    2009-11-01

    With short wavelength (248 nm), large bandwidth (˜1 THz), and ISI beam smoothing, Nike KrF laser provides unique opportunities of LPI research for direct-drive inertial confinement fusion. Previous experiments at intensities (10^15˜10^16 W/cm^2) exceeded two-plasmon decay (TPD) instability threshold using 12 beam-lines of Nike laser.^a,b For further experiments to study LPI excitation in bigger plasma volumes, 44 Nike main beams have been used to produce plasmas with total laser energies up to 1 kJ of ˜350 psec FWHM pulses. This talk will present results of the recent LPI experiment focusing on light emission data in spectral ranges relevant to the Raman (SRS) and TPD instabilities. The primary diagnostics were time-resolved spectrometers with an absolute-intensity-calibrated photodiode array in (0.4˜0.8)φ0 and a streak camera near 0.5φ0. Blackbody temperature and expansion speed measurements of the plasmas were also made. The experiment was conducted at laser intensities of (1˜4)x10^15 W/cm^2 on solid planar CH targets. ^a J. L. Weaver, et al, NO4.14, APS DPP (2008) ^b J. Oh, et al, NO4.15, APS DPP (2008) * Work supported by DoE/NNSA and performed at Naval Research Laboratory.

  2. The MICE Muon Beam on ISIS and the beam-line instrumentation of the Muon Ionization Cooling Experiment

    CERN Document Server

    Bogomilov, M.; Kolev, D.; Russinov, I.; Tsenov, R.; Vankova-Kirilova, G.; Wang, L.; Xu, F.Y.; Zheng, S.X.; Bertoni, R.; Bonesini, M.; Ferri, F.; Lucchini, G.; Mazza, R.; Paleari, F.; Strati, F.; Palladino, V.; Cecchet, G.; de Bari, A.; Capponi, M.; Cirillo, A.; Iaciofano, A.; Manfredini, A.; Parisi, M.; Orestano, D.; Pastore, F.; Tonazzo, A.; Tortora, L.; Mori, Y.; Kuno, Y.; Sakamoto, H.; Sato, A.; Yano, T.; Yoshida, M.; Ishimoto, S.; Suzuki, S.; Yoshimura, K.; Filthaut, F.; Garoby, R.; Gilardoni, S.; Gruber, P.; Hanke, K.; Haseroth, H.; Janot, P.; Lombardi, A.; Ramberger, S.; Vretenar, M.; Bene, P.; Blondel, A.; Cadoux, F.; Graulich, J.S.; Grichine, V.; Gschwendtner, E.; Masciocchi, F.; Sandstrom, R.; Verguilov, V.; Wisting, H.; Petitjean, C.; Seviour, R.; Alexander, J.; Charnley, G.; Collomb, N.; Griffiths, S.; Martlew, B.; Moss, A.; Mullacrane, I.; Oates, A.; Owens, P.; White, C.; York, S.; Adams, D.; Apsimon, R.; Barclay, P.; Baynham, D.E.; Bradshaw, T.W.; Courthold, M.; Drumm, P.; Edgecock, R.; Hayler, T.; Hills, M.; Ivaniouchenkov, Y.; Jones, A.; Lintern, A.; MacWaters, C.; Nelson, C.; Nichols, A.; Preece, R.; Ricciardi, S.; Rochford, J.H.; Rogers, C.; Spensley, W.; Tarrant, J.; Tilley, K.; Watson, S.; Wilson, A.; Forrest, D.; Soler, F.J.P.; Walaron, K.; Cooke, P.; Gamet, R.; Alekou, A.; Apollonio, M.; Barber, G.; Clark, D.; Clark, I.; Dobbs, A.; Dornan, P.; Fish, A.; Hare, R.; Greenwood, S.; Jamdagni, A.; Kasey, V.; Khaleeq, M.; Leaver, J.; Long, K.; McKigney, E.; Matsushita, T.; Pasternak, J.; Sashalmi, T.; Savidge, T.; Takahashi, M.; Blackmore, V.; Carlisle, T.; Cobb, J.H.; Lau, W.; Rayner, M.; Tunnell, C.D.; Witte, H.; Yang, S.; Booth, C.N.; Hodgson, P.; Howlett, L.; Nicholson, R.; Overton, E.; Robinson, M.; Smith, P.; Adey, D.; Back, J.; Boyd, S.; Harrison, P.; Ellis, M.; Kyberd, P.; Littlefield, M.; Nebrensky, J.J.; Bross, A.D.; Geer, S.; Neuffer, D.; Moretti, A.; Popovic, M.; Cummings, M.A.C.; Roberts, T.J.; DeMello, A.; Green, M.A.; Li, D.; Virostek, S.; Zisman, M.S.; Freemire, B.; Hanlet, P.; Huang, D.; Kafka, G.; Kaplan, D.M.; Snopok, P.; Torun, Y.; Blot, S.; Kim, Y.K.; Bravar, U.; Onel, Y.; Cline, D.; Fukui, Y.; Lee, K.; Yang, X.; Rimmer, R.A.; Cremaldi, L.M.; Gregoire, G.; Hart, T.L.; Sanders, D.A.; Summers, D.J.; Coney, L.; Fletcher, R.; Hanson, G.G.; Heidt, C.; Gallardo, J.; Kahn, S.; Kirk, H.; Palmer, R.B.

    2012-01-01

    The international Muon Ionization Cooling Experiment (MICE), which is under construction at the Rutherford Appleton Laboratory (RAL), will demonstrate the principle of ionization cooling as a technique for the reduction of the phase-space volume occupied by a muon beam. Ionization cooling channels are required for the Neutrino Factory and the Muon Collider. MICE will evaluate in detail the performance of a single lattice cell of the Feasibility Study 2 cooling channel. The MICE Muon Beam has been constructed at the ISIS synchrotron at RAL, and in MICE Step I, it has been characterized using the MICE beam-instrumentation system. In this paper, the MICE Muon Beam and beam-line instrumentation are described. The muon rate is presented as a function of the beam loss generated by the MICE target dipping into the ISIS proton beam. For a 1 V signal from the ISIS beam-loss monitors downstream of our target we obtain a 30 KHz muon rate, with a neglible pion contamination in the beam.

  3. Finite element simulations of interactions between multiple hydraulic fractures in a poroelastic rock

    DEFF Research Database (Denmark)

    Salimzadeh, Saeed; Usui, Tomoya; Paluszny, Adriana

    2017-01-01

    A fully coupled three-dimensional finite-element model for hydraulic fractures in permeable rocks is presented, and used to investigate the ranges of applicability of the classical analytical solutions that are known to be valid in limiting cases. This model simultaneously accounts for fluid flow...

  4. Accuracy of finite-element models for the stress analysis of multiple-holed moderator blocks

    International Nuclear Information System (INIS)

    Smith, P.D.; Sullivan, R.M.; Lewis, A.C.; Yu, H.J.

    1981-01-01

    Two steps have been taken to quantify and improve the accuracy in the analysis. First, the limitations of various approximation techniques have been studied with the aid of smaller benchmark problems containing fewer holes. Second, a new family of computer programs has been developed for handling such large problems. This paper describes the accuracy studies and the benchmark problems. A review is given of some proposed modeling techniques including local mesh refinement, homogenization, a special-purpose finite element, and substructuring. Some limitations of these approaches are discussed. The new finite element programs and the features that contribute to their efficiency are discussed. These include a standard architecture for out-of-core data processing and an equation solver that operates on a peripheral array processor. The central conclusions of the paper are: (1) modeling approximation methods such as local mesh refinement and homogenization tend to be unreliable, and they should be justified by a fine mesh benchmark analysis; and (2) finite element codes are now available that can achieve accurate solutions at a reasonable cost, and there is no longer a need to employ modeling approximations in the two-dimensional analysis of HTGR fuel elements. 10 figures

  5. Trace element analysis of environmental samples by multiple prompt gamma-ray analysis method

    International Nuclear Information System (INIS)

    Oshima, Masumi; Matsuo, Motoyuki; Shozugawa, Katsumi

    2011-01-01

    The multiple γ-ray detection method has been proved to be a high-resolution and high-sensitivity method in application to nuclide quantification. The neutron prompt γ-ray analysis method is successfully extended by combining it with the γ-ray detection method, which is called Multiple prompt γ-ray analysis, MPGA. In this review we show the principle of this method and its characteristics. Several examples of its application to environmental samples, especially river sediments in the urban area and sea sediment samples are also described. (author)

  6. On the multiplicative order of elements in Wiedemann's towers of finite fields

    Directory of Open Access Journals (Sweden)

    R. Popovych

    2016-01-01

    Full Text Available We consider recursive binary finite field extensions $E_{i+1} =E_{i} (x_{i+1} $, $i\\ge -1$, defined by D. Wiedemann. The main object of the paper is to give some proper divisors of the Fermat numbers $N_{i} $ that are not equal to the multiplicative order $O(x_{i} $.

  7. Beam Line Design and Beam Physics Study of Energy Recovery Linac Free Electron Laser at Peking University

    International Nuclear Information System (INIS)

    Wang, Guimei

    2011-01-01

    Energy recovering linac (ERL) offers an attractive alternative for generating intense beams of charged particles by approaching the operational efficiency of a storage ring while maintaining the superior beam quality typical of a linear accelerator. In ERLs, the decelerated beam cancels the beam loading effects of the accelerated beam with high repetition rate. Therefore, ERLs can, in principle, accelerate very high average currents with only modest amounts of RF power. So the efficiency of RF power to beam is much higher. Furthermore, the energy of beam to dump is lower, so it will reduce dump radiation. With the successful experiments in large maximum-to-injection energy ratio up to 51:1 and high power FEL up to 14kW, the use of ERL, especially combining with superconducting RF technology, provides a potentially powerful new paradigm for generation of the charged particle beams used in MW FEL, synchrotron radiation sources, high-energy electron cooling devices and so on. The 3+1/2 DC-SC photo injector and two 9cell TESLA superconducting cavity for IR SASE FEL in PKU provides a good platform to achieve high average FEL with Energy Recovery. The work of this thesis is on Beam line design and Beam dynamics study of Energy Recovery Linac Free Electron Laser for Peking University. It is the upgrade of PKU facility, which is under construction. With ERL, this facility can work in CW mode, so it can operate high average beam current without RF power constraint in main linac and generate high average FEL power. Moreover, it provides a test facility to study the key technology in ERL. System parameters are optimized for PKU ERL-FEL. The oscillation FEL output power is studied with different bunch charge, transverse emittance, bunch length and energy spread. The theory of optimal RF power and Q ext with ERL and without ERL is analyzed and applied to PKU injector and linac including microphonic effect. pace charge effect in the injector and merger is studied for beam energy

  8. Beam Line Design and Beam Physics Study of Energy Recovery Linac Free Electron Laser at Peking University

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Guimei [Peking Univ., Beijing (China)

    2011-12-31

    Energy recovering linac (ERL) offers an attractive alternative for generating intense beams of charged particles by approaching the operational efficiency of a storage ring while maintaining the superior beam quality typical of a linear accelerator. In ERLs, the decelerated beam cancels the beam loading effects of the accelerated beam with high repetition rate. Therefore, ERLs can, in principle, accelerate very high average currents with only modest amounts of RF power. So the efficiency of RF power to beam is much higher. Furthermore, the energy of beam to dump is lower, so it will reduce dump radiation. With the successful experiments in large maximum-to-injection energy ratio up to 51:1 and high power FEL up to 14kW, the use of ERL, especially combining with superconducting RF technology, provides a potentially powerful new paradigm for generation of the charged particle beams used in MW FEL, synchrotron radiation sources, high-energy electron cooling devices and so on. The 3+1/2 DC-SC photo injector and two 9cell TESLA superconducting cavity for IR SASE FEL in PKU provides a good platform to achieve high average FEL with Energy Recovery. The work of this thesis is on Beam line design and Beam dynamics study of Energy Recovery Linac Free Electron Laser for Peking University. It is the upgrade of PKU facility, which is under construction. With ERL, this facility can work in CW mode, so it can operate high average beam current without RF power constraint in main linac and generate high average FEL power. Moreover, it provides a test facility to study the key technology in ERL. System parameters are optimized for PKU ERL-FEL. The oscillation FEL output power is studied with different bunch charge, transverse emittance, bunch length and energy spread. The theory of optimal RF power and Q{sub ext} with ERL and without ERL is analyzed and applied to PKU injector and linac including microphonic effect. pace charge effect in the injector and merger is studied for beam

  9. Role of NAA in characterizations of sampling behaviors of multiple elements in CRMs

    International Nuclear Information System (INIS)

    Tian Weizhi; Ni Bangfa; Wang Pingsheng; Nie Huiling

    1997-01-01

    Taking the advantage of high precision and accuracy of neutron activation analysis (NAA), sampling constants have been determined for multielements in several international and Chinese reference materials. The suggested technique may be used for finding elements in existing CRMs qualified for quality control (QC) of small size samples (several mg or less), and characterizing sampling behaviors of multielements in new CRMs specifically made for QC of microanalysis

  10. Role of NAA in determination and characterisation of sampling behaviours of multiple elements in CRMs

    International Nuclear Information System (INIS)

    Tian Weizhi; Ni Bangfa; Wang Pingsheng; Nie Huiling

    2002-01-01

    Taking the advantage of high precision and accuracy of neutron activation analysis (NAA), sampling constants have been determined for multielements in several international and Chinese reference materials. The suggested technique may be used for finding elements in existing CRMs qualified for quality control (QC) of small size samples (several mg or less), and characterizing sampling behaviors of multielements in new CRMs specifically made for QC of microanalysis. (author)

  11. The protist Trichomonas vaginalis harbors multiple lineages of transcriptionally active Mutator-like elements

    Directory of Open Access Journals (Sweden)

    Pereira Gonçalo AG

    2009-07-01

    Full Text Available Abstract Background For three decades the Mutator system was thought to be exclusive of plants, until the first homolog representatives were characterized in fungi and in early-diverging amoebas earlier in this decade. Results Here, we describe and characterize four families of Mutator-like elements in a new eukaryotic group, the Parabasalids. These Trichomonas vaginalis Mutator- like elements, or TvMULEs, are active in T. vaginalis and patchily distributed among 12 trichomonad species and isolates. Despite their relatively distinctive amino acid composition, the inclusion of the repeats TvMULE1, TvMULE2, TvMULE3 and TvMULE4 into the Mutator superfamily is justified by sequence, structural and phylogenetic analyses. In addition, we identified three new TvMULE-related sequences in the genome sequence of Candida albicans. While TvMULE1 is a member of the MuDR clade, predominantly from plants, the other three TvMULEs, together with the C. albicans elements, represent a new and quite distinct Mutator lineage, which we named TvCaMULEs. The finding of TvMULE1 sequence inserted into other putative repeat suggests the occurrence a novel TE family not yet described. Conclusion These findings expand the taxonomic distribution and the range of functional motif of MULEs among eukaryotes. The characterization of the dynamics of TvMULEs and other transposons in this organism is of particular interest because it is atypical for an asexual species to have such an extreme level of TE activity; this genetic landscape makes an interesting case study for causes and consequences of such activity. Finally, the extreme repetitiveness of the T. vaginalis genome and the remarkable degree of sequence identity within its repeat families highlights this species as an ideal system to characterize new transposable elements.

  12. Determine Multiple Elements Simultaneously in the Sera of Umbilical Cord Blood Samples-a Very Simple Method.

    Science.gov (United States)

    Liang, Chunmei; Li, Zhijuan; Xia, Xun; Wang, Qunan; Tao, Ruiwen; Tao, Yiran; Xiang, Haiyun; Tong, Shilu; Tao, Fangbiao

    2017-05-01

    Analyzing the concentrations of heavy metals in the sera of umbilical cord blood samples can provide useful information about prenatal exposure to environmental agents. An analytical method based on ICP-MS to simultaneously determine multiple elements in umbilical cord blood samples was developed for assessing the in utero exposure to metallic and metalloid elements. The method only required as little as 100 μL of serum diluted 1:25 for direct analysis. Matrix-matched protocol was used to eliminate mass matrix interference and kinetic energy discrimination mode was used to eliminate the polyatomic ion interference. The assay was completed on average within 4 min with the detection limits ranging from 0.0002 to 44.4 μg/L for all the targeted elements. The detection rates for most of elements were 100 % other than cadmium (Cd), lead (Pb), and mercury (Hg). The testing results of the certified reference materials were ideal. The method is simple and sensitive, so it is suitable for the monitoring of large quantities of samples.

  13. Three-dimensional finite elements for the analysis of soil contamination using a multiple-porosity approach

    Science.gov (United States)

    El-Zein, Abbas; Carter, John P.; Airey, David W.

    2006-06-01

    A three-dimensional finite-element model of contaminant migration in fissured clays or contaminated sand which includes multiple sources of non-equilibrium processes is proposed. The conceptual framework can accommodate a regular network of fissures in 1D, 2D or 3D and immobile solutions in the macro-pores of aggregated topsoils, as well as non-equilibrium sorption. A Galerkin weighted-residual statement for the three-dimensional form of the equations in the Laplace domain is formulated. Equations are discretized using linear and quadratic prism elements. The system of algebraic equations is solved in the Laplace domain and solution is inverted to the time domain numerically. The model is validated and its scope is illustrated through the analysis of three problems: a waste repository deeply buried in fissured clay, a storage tank leaking into sand and a sanitary landfill leaching into fissured clay over a sand aquifer.

  14. Research and development activity for the construction of beam lines in spring-8 (a new 8GeV SR ring)

    International Nuclear Information System (INIS)

    Watanabe, Tsutomu; Ohno, Hideo; Iwasaki, Hitoshi; Sasaki, Teikichi

    1990-01-01

    A research and development activity for a new large-scale synchrotron radiation facility started in Japan in 1987. The Institute of Physical and Chemical Research (RIKEN) and Japan Atomic Energy Research Institute (JAERI) have been participating this project. In particular, a joint team for this SR project was formed in 1988 to perform efficient research and development activities in cooperation. The new facility is scheduled to be in normal operation in 1998. The maximum energy of the electron or positron beams in the storage ring (SPring-8) is planned to be 8 GeV. The present report particularly describes the beam line front-end, research and development of optical components, beam lines for radioactive materials, insertion devices, activities of the atomic physics group, double focusing monochromator for macromolecular crystallography, preceding studies on magnetic and Compton scattering, EXAFS and XANES studies of biopolymers, studies on surface properties, and applications. (N.K.)

  15. [Simultaneous determination of multiple elements in airborne particulate samples by X-ray fluorescence spectrometry].

    Science.gov (United States)

    Takada, T; Hitosugi, M; Kadowaki, T; Kudo, M

    1983-07-01

    An energy dispersive X-ray fluorescence spectrometer (EDX) has been applied to determine multielements in the workplace air. The standards for X-ray fluorescence analysis were prepared by the chelate precipitation method on polyvinyl chloride (PVC) membrane filter. And, the specimens were prepared to deposit various metal compounds of different chemical forms by the suspension method on PVC membrane filter, and they were determined with EDX and atomic absorption spectrometer (AAS). The results obtained were as follows. Though there is a difference by each element, an amount less than 3 microgram/cm2 per unit area makes it possible to undergo multielement analysis, that is, is has no influence on fine particle effect (particle size; under 5 microns). Then, effects of the X-ray intensity by different chemical forms are negligible. At the presence the neighboring element and other elements this technique showed greater precision by carrying out on corrective treatment, etc. The coefficient of variation of this technique was in the range of 2.5-6.5% at DDTC-Cu of 0.5-5.0 micrograms/cm2, with the limit of detection for As : 0.002 microgram/cm2, Zn : 0.003 microgram/cm2, Pb : 0.003 microgram/cm2, Cu : 0.004 microgram/cm2, Ni : 0.003 microgram/cm2, Fe : 0.005 microgram/cm2, Mn : 0.008 microgram/cm2, Cr : 0.013 microgram/cm2, respectively. Aerosols collected at the workplace were analyzed with EDX and AAS, and the obtained results showed good agreement with such regression line as y = 1.04 chi + 0.04, the coefficient of correlation being r = 0.995. From these results, this technique was found to be a very excellent method for monitoring of multielements in the workplace air.

  16. Investigations of multiple backscattering and albedos of 1.12 MeV gamma photons in elements and alloys

    International Nuclear Information System (INIS)

    Sabharwal, Arvind D.; Singh, Bhajan; Sandhu, B.S.

    2009-01-01

    The energy and intensity distributions of multiple backscattering of 1.12 MeV gamma photons emerging from targets of elements and alloys are observed as a function of thickness and atomic number (Z) of the target. The numbers of these multiply backscattered events show an increase with increase in target thickness, and then saturate for a particular thickness of the target called saturation thickness (depth). The saturation thickness decreases with increasing atomic number and varies as e -Z . The multiple backscattering, an interfering background noise in Compton profile, has been successfully used to assign the 'effective atomic number' to alloys. Monte Carlo calculations also support the present experimental results. The number, energy and dose albedos are also found to be saturating for the same thickness where the numbers of multiply backscattered events saturate.

  17. Experimental investigations of multiple scattering of 662 keV gamma photons in elements and binary alloys

    International Nuclear Information System (INIS)

    Singh, Gurvinderjit; Singh, Manpreet; Sandhu, B.S.; Singh, Bhajan

    2008-01-01

    The energy, intensity and angular distributions of multiple scattering of 662 keV gamma photons, emerging from targets of pure elements and binary alloys, are observed as a function of target thickness in reflection and transmission geometries. The observed spectra recorded by a properly shielded NaI (Tl) scintillation detector, in addition to singly scattered events, consist of photons scattered more than once for thick targets. To extract the contribution of multiply scattered photons from the measured spectra, a singly scattered distribution is reconstructed analytically. We observe that the numbers of multiply scattered events increase with increase in target thickness, and saturate for a particular thickness called saturation thickness. The saturation thickness decreases with increasing atomic number. The multiple scattering, an interfering background noise in Compton profiles and Compton cross-section measurements, has been successfully used as a new technique to assign the 'effective atomic number' to binary alloys. Monte Carlo calculations support the present experimental results

  18. Matrix-type multiple reciprocity boundary element method for solving three-dimensional two-group neutron diffusion equations

    International Nuclear Information System (INIS)

    Itagaki, Masafumi; Sahashi, Naoki.

    1997-01-01

    The multiple reciprocity boundary element method has been applied to three-dimensional two-group neutron diffusion problems. A matrix-type boundary integral equation has been derived to solve the first and the second group neutron diffusion equations simultaneously. The matrix-type fundamental solutions used here satisfy the equation which has a point source term and is adjoint to the neutron diffusion equations. A multiple reciprocity method has been employed to transform the matrix-type domain integral related to the fission source into an equivalent boundary one. The higher order fundamental solutions required for this formulation are composed of a series of two types of analytic functions. The eigenvalue itself is also calculated using only boundary integrals. Three-dimensional test calculations indicate that the present method provides stable and accurate solutions for criticality problems. (author)

  19. The Two-Beam-Line Ion Implanter and Review of its Application to Creation of Complex Layers by the IBAD Method

    International Nuclear Information System (INIS)

    Rajchel, B.; Drwiega, M.; Lipinska, E.; Hajduk, R.

    1998-12-01

    The present status of the two-beam-line ion implanter its basic specifications after the upgrading and the possibilities of its application to ion engineering methods is presented. The examples of created layers (DLC, TiN x , SiC x ) and research methods applied to find out the features of the ion beam assisted deposited coatings are presented in order to prove the suitability of the device to scientific studies

  20. Analytical and experimental investigation on a multiple-mass-element pendulum impact damper for vibration mitigation

    Science.gov (United States)

    Egger, Philipp; Caracoglia, Luca

    2015-09-01

    Impact dampers are often used in the field of civil, mechanical and aerospace engineering for reducing structural vibrations. The behavior of this type of passive control device has been investigated for several decades. In this research a distributed-mass impact damper, similar to the "chain damper" used in wind engineering, has been examined and applied to the vibration reduction on a slender line-like structural element (stay-cable). This study is motivated by a practical problem and describes the derivation of a reduced-order model for explaining the behavior, observed during a field experiment on a prototype system. In its simplest form, the dynamics of the apparatus is modeled as a "resilient damper", composed of mass-spring-dashpot secondary elements, attached to the primary structure. Various sources of excitation are analyzed: free vibration, external harmonic force and random excitation. The proposed model is general and potentially applicable to the analysis of several structural systems. The study also shows that the model can adequately describe and explain the experimentally observed behavior.

  1. Piezoelectric materials selection for sensor applications using finite element and multiple attribute decision-making approaches

    Directory of Open Access Journals (Sweden)

    Anuruddh Kumar

    2015-03-01

    Full Text Available This paper examines the selection and performance evaluation of a variety of piezoelectric materials for cantilever-based sensor applications. The finite element analysis method is implemented to evaluate the relative importance of materials properties such as Young's Modulus (E, piezoelectric stress constants (e31, dielectric constant (ε and Poisson's ratio (υ for cantilever-based sensor applications. An analytic hierarchy process (AHP is used to assign weights to the properties that are studied for the sensor structure under study. A technique for order preference by similarity to ideal solution (TOPSIS is used to rank the performance of the piezoelectric materials in the context of sensor voltage outputs. The ranking achieved by the TOPSIS analysis is in good agreement with the results obtained from finite element method simulation. The numerical simulations show that K0.5Na0.5NbO3–LiSbO3 (KNN–LS materials family is important for sensor application. Young's modulus (E is most influencing material's property followed by piezoelectric constant (e31, dielectric constant (ε and Poisson's ratio (υ for cantilever-based piezoelectric sensor applications.

  2. Detecting the limits of regulatory element conservation anddivergence estimation using pairwise and multiple alignments

    Energy Technology Data Exchange (ETDEWEB)

    Pollard, Daniel A.; Moses, Alan M.; Iyer, Venky N.; Eisen,Michael B.

    2006-08-14

    Background: Molecular evolutionary studies of noncodingsequences rely on multiple alignments. Yet how multiple alignmentaccuracy varies across sequence types, tree topologies, divergences andtools, and further how this variation impacts specific inferences,remains unclear. Results: Here we develop a molecular evolutionsimulation platform, CisEvolver, with models of background noncoding andtranscription factor binding site evolution, and use simulated alignmentsto systematically examine multiple alignment accuracy and its impact ontwo key molecular evolutionary inferences: transcription factor bindingsite conservation and divergence estimation. We find that the accuracy ofmultiple alignments is determined almost exclusively by the pairwisedivergence distance of the two most diverged species and that additionalspecies have a negligible influence on alignment accuracy. Conservedtranscription factor binding sites align better than surroundingnoncoding DNA yet are often found to be misaligned at relatively shortdivergence distances, such that studies of binding site gain and losscould easily be confounded by alignment error. Divergence estimates frommultiple alignments tend to be overestimated at short divergencedistances but reach a tool specific divergence at which they cease toincrease, leading to underestimation at long divergences. Our moststriking finding was that overall alignment accuracy, binding sitealignment accuracy and divergence estimation accuracy vary greatly acrossbranches in a tree and are most accurate for terminal branches connectingsister taxa and least accurate for internal branches connectingsub-alignments. Conclusions: Our results suggest that variation inalignment accuracy can lead to errors in molecular evolutionaryinferences that could be construed as biological variation. Thesefindings have implications for which species to choose for analyses, whatkind of errors would be expected for a given set of species and howmultiple alignment tools and

  3. Phylogenetic consistencies among chondrichthyan and teleost fishes in their bioaccumulation of multiple trace elements from seawater

    Energy Technology Data Exchange (ETDEWEB)

    Jeffree, Ross A., E-mail: R.Jeffree@iaea.org [IAEA Marine Environment Laboratories, 4, Quai Antoine 1er, MC 98000 (Monaco); Oberhansli, Francois; Teyssie, Jean-Louis [IAEA Marine Environment Laboratories, 4, Quai Antoine 1er, MC 98000 (Monaco)

    2010-07-15

    Multi-tracer experiments determined the accumulation from seawater of selected radioactive trace elements (Mn-54, Co-60, Zn-65, Cs-134, Am-241, Cd-109, Ag-110m, Se-75 and Cr-51) by three teleost and three chondrichthyan fish species to test the hypothesis that these phylogenetic groups have different bioaccumulation characteristics, based on previously established contrasts between the carcharhiniform chondrichthyan Scyliorhinus canicula (dogfish) and the pleuronectiform teleost Psetta maxima (turbot). Discriminant function analysis on whole body: water concentration factors (CFs) separated dogfish and turbot in two independent experiments. Classification functions grouped the perciform teleosts, seabream (Sparus aurata) and seabass (Dicentrarchus labrax), with turbot and grouped the chondrichthyans, undulate ray (Raja undulata; Rajiformes) and spotted torpedo (Torpedo marmorata; Torpediniformes), with dogfish, thus supporting our hypothesis. Hierarchical classificatory, multi-dimensional scaling and similarity analyses based on the CFs for the nine radiotracers, also separated all three teleosts (that aggregated lower in the hierarchy) from the three chondrichthyan species. The three chondrichthyans were also more diverse amongst themselves compared to the three teleosts. Particular trace elements that were more important in separating teleosts and chondrichthyans were Cs-134 that was elevated in teleosts and Zn-65 that was elevated in chondrichthyans, these differences being due to their differential rates of uptake rather than loss. Chondrichthyans were also higher in Cr-51, Co-60, Ag-110m and Am-241, whereas teleosts were higher only in Mn-54. These contrasts in bioaccumulation patterns between teleosts and chondrichthyans are interpreted in the context of both proximate causes of underlying differences in physiology and anatomy, as well as the ultimate cause of their evolutionary divergence over more than 500 million years before present (MyBP). Our results

  4. Phylogenetic consistencies among chondrichthyan and teleost fishes in their bioaccumulation of multiple trace elements from seawater

    International Nuclear Information System (INIS)

    Jeffree, Ross A.; Oberhansli, Francois; Teyssie, Jean-Louis

    2010-01-01

    Multi-tracer experiments determined the accumulation from seawater of selected radioactive trace elements (Mn-54, Co-60, Zn-65, Cs-134, Am-241, Cd-109, Ag-110m, Se-75 and Cr-51) by three teleost and three chondrichthyan fish species to test the hypothesis that these phylogenetic groups have different bioaccumulation characteristics, based on previously established contrasts between the carcharhiniform chondrichthyan Scyliorhinus canicula (dogfish) and the pleuronectiform teleost Psetta maxima (turbot). Discriminant function analysis on whole body: water concentration factors (CFs) separated dogfish and turbot in two independent experiments. Classification functions grouped the perciform teleosts, seabream (Sparus aurata) and seabass (Dicentrarchus labrax), with turbot and grouped the chondrichthyans, undulate ray (Raja undulata; Rajiformes) and spotted torpedo (Torpedo marmorata; Torpediniformes), with dogfish, thus supporting our hypothesis. Hierarchical classificatory, multi-dimensional scaling and similarity analyses based on the CFs for the nine radiotracers, also separated all three teleosts (that aggregated lower in the hierarchy) from the three chondrichthyan species. The three chondrichthyans were also more diverse amongst themselves compared to the three teleosts. Particular trace elements that were more important in separating teleosts and chondrichthyans were Cs-134 that was elevated in teleosts and Zn-65 that was elevated in chondrichthyans, these differences being due to their differential rates of uptake rather than loss. Chondrichthyans were also higher in Cr-51, Co-60, Ag-110m and Am-241, whereas teleosts were higher only in Mn-54. These contrasts in bioaccumulation patterns between teleosts and chondrichthyans are interpreted in the context of both proximate causes of underlying differences in physiology and anatomy, as well as the ultimate cause of their evolutionary divergence over more than 500 million years before present (MyBP). Our results

  5. TURTLE with MAD input (Trace Unlimited Rays Through Lumped Elements) -- A computer program for simulating charged particle beam transport systems and DECAY TURTLE including decay calculations

    Energy Technology Data Exchange (ETDEWEB)

    Carey, D.C.

    1999-12-09

    TURTLE is a computer program useful for determining many characteristics of a particle beam once an initial design has been achieved, Charged particle beams are usually designed by adjusting various beam line parameters to obtain desired values of certain elements of a transfer or beam matrix. Such beam line parameters may describe certain magnetic fields and their gradients, lengths and shapes of magnets, spacings between magnetic elements, or the initial beam accepted into the system. For such purposes one typically employs a matrix multiplication and fitting program such as TRANSPORT. TURTLE is designed to be used after TRANSPORT. For convenience of the user, the input formats of the two programs have been made compatible. The use of TURTLE should be restricted to beams with small phase space. The lumped element approximation, described below, precludes the inclusion of the effect of conventional local geometric aberrations (due to large phase space) or fourth and higher order. A reading of the discussion below will indicate clearly the exact uses and limitations of the approach taken in TURTLE.

  6. TURTLE with MAD input (Trace Unlimited Rays Through Lumped Elements) -- A computer program for simulating charged particle beam transport systems and DECAY TURTLE including decay calculations

    International Nuclear Information System (INIS)

    Carey, D.C.

    1999-01-01

    TURTLE is a computer program useful for determining many characteristics of a particle beam once an initial design has been achieved, Charged particle beams are usually designed by adjusting various beam line parameters to obtain desired values of certain elements of a transfer or beam matrix. Such beam line parameters may describe certain magnetic fields and their gradients, lengths and shapes of magnets, spacings between magnetic elements, or the initial beam accepted into the system. For such purposes one typically employs a matrix multiplication and fitting program such as TRANSPORT. TURTLE is designed to be used after TRANSPORT. For convenience of the user, the input formats of the two programs have been made compatible. The use of TURTLE should be restricted to beams with small phase space. The lumped element approximation, described below, precludes the inclusion of the effect of conventional local geometric aberrations (due to large phase space) or fourth and higher order. A reading of the discussion below will indicate clearly the exact uses and limitations of the approach taken in TURTLE

  7. Sensitive targeted multiple protein quantification based on elemental detection of Quantum Dots

    Energy Technology Data Exchange (ETDEWEB)

    Montoro Bustos, Antonio R.; Garcia-Cortes, Marta [Department of Physical and Analytical Chemistry, University of Oviedo, Julián Clavería 8, Oviedo 33006 (Spain); González-Iglesias, Hector [Fundación de Investigación Oftalmológica, Instituto Oftalmológico Fernandez-Vega, Avenida Doctores Fernández-Vega, 34, Oviedo 33012 (Spain); Ruiz Encinar, Jorge, E-mail: ruizjorge@uniovi.es [Department of Physical and Analytical Chemistry, University of Oviedo, Julián Clavería 8, Oviedo 33006 (Spain); Costa-Fernández, José M. [Department of Physical and Analytical Chemistry, University of Oviedo, Julián Clavería 8, Oviedo 33006 (Spain); Coca-Prados, Miguel [Fundación de Investigación Oftalmológica, Instituto Oftalmológico Fernandez-Vega, Avenida Doctores Fernández-Vega, 34, Oviedo 33012 (Spain); Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06510 (United States); Sanz-Medel, Alfredo, E-mail: asm@uniovi.es [Department of Physical and Analytical Chemistry, University of Oviedo, Julián Clavería 8, Oviedo 33006 (Spain)

    2015-06-16

    Highlights: • Novel generic platform for multiparametric quantification of proteins. • QDs labeling and ICP-MS detection allow significant analytical signal amplification. • ICP-MS mass balances information provided an internal validation of the immunoassay. • Multiparametric determination of 5 proteins in human serum samples. • ICP-MS reduced matrix effects as compared to other conventional detection techniques. - Abstract: A generic strategy based on the use of CdSe/ZnS Quantum Dots (QDs) as elemental labels for protein quantification, using immunoassays with elemental mass spectrometry (ICP-MS), detection is presented. In this strategy, streptavidin modified QDs (QDs-SA) are bioconjugated to a biotinylated secondary antibody (b-Ab{sub 2}). After a multi-technique characterization of the synthesized generic platform (QDs-SA-b-Ab{sub 2}) it was applied to the sequential quantification of five proteins (transferrin, complement C3, apolipoprotein A1, transthyretin and apolipoprotein A4) at different concentration levels in human serum samples. It is shown how this generic strategy does only require the appropriate unlabeled primary antibody for each protein to be detected. Therefore, it introduces a way out to the need for the cumbersome and specific bioconjugation of the QDs to the corresponding specific recognition antibody for every target analyte (protein). Results obtained were validated with those obtained using UV–vis spectrophotometry and commercial ELISA Kits. As expected, ICP-MS offered one order of magnitude lower DL (0.23 fmol absolute for transferrin) than the classical spectrophotometric detection (3.2 fmol absolute). ICP-MS precision and detection limits, however turned out to be compromised by procedural blanks. The full analytical performance of the ICP-MS-based immunoassay proposed was assessed for detection of transferrin (Tf), present at the low ng mL{sup −1} range in a complex “model” synthetic matrix, where the total protein

  8. Optical frequency-domain reflectometry using multiple wavelength-swept elements of a DFB laser array

    Science.gov (United States)

    DiLazaro, Tom; Nehmetallah, Georges

    2017-02-01

    Coherent optical frequency-domain reflectometry (C-OFDR) is a distance measurement technique with significant sensitivity and detector bandwidth advantages over normal time-of-flight methods. Although several swept-wavelength laser sources exist, many exhibit short coherence lengths, or require precision mechanical tuning components. Semiconductor distributed feedback lasers (DFBs) are advantageous as a mid-to-long range OFDR source because they exhibit a narrow linewidth and can be rapidly tuned simply via injection current. However, the sweep range of an individual DFB is thermally limited. Here, we present a novel high-resolution OFDR system that uses a compact, monolithic 12-element DFB array to create a continuous, gap-free sweep over a wide wavelength range. Wavelength registration is provided by the incorporation of a HCN gas cell and reference interferometer. The wavelength-swept spectra of the 12 DFBs are combined in post-processing to achieve a continuous total wavelength sweep of more than 40 nm (5.4 THz) in the telecommunications C-Band range.

  9. Acceptance of spent nuclear fuel in multiple element sealed canisters by the Federal Waste Management System

    International Nuclear Information System (INIS)

    1990-03-01

    This report is one of a series of eight prepared by E.R. Johnson Associates, Inc. (JAI) under ORNL's contract with DOE's OCRWM Systems Integration Program and in support of the Annual Capacity Report (ACR) Issue Resolution Process. The report topics relate specifically to the list of high priority technical waste acceptance issues developed jointly by DOE and a utility-working group. JAI performed various analyses and studies on each topic to serve as starting points for further discussion and analysis leading eventually to finalizing the process by which DOE will accept spent fuel and waste into its waste management system. The eight reports are concerned with the conditions under which spent fuel and high level waste will be accepted in the following categories: (1) failed fuel; (2) consolidated fuel and associated structural parts; (3) non-fuel-assembly hardware; (4) fuel in metal storage casks; (5) fuel in multi-element sealed canisters; (6) inspection and testing requirements for wastes; (7) canister criteria; (8) spent fuel selection for delivery; and (9) defense and commercial high-level waste packages. 14 refs., 27 figs

  10. Expression of the central growth regulator BIG BROTHER is regulated by multiple cis-elements

    Directory of Open Access Journals (Sweden)

    Breuninger Holger

    2012-03-01

    Full Text Available Abstract Background Much of the organismal variation we observe in nature is due to differences in organ size. The observation that even closely related species can show large, stably inherited differences in organ size indicates a strong genetic component to the control of organ size. Despite recent progress in identifying factors controlling organ growth in plants, our overall understanding of this process remains limited, partly because the individual factors have not yet been connected into larger regulatory pathways or networks. To begin addressing this aim, we have studied the upstream regulation of expression of BIG BROTHER (BB, a central growth-control gene in Arabidopsis thaliana that prevents overgrowth of organs. Final organ size and BB expression levels are tightly correlated, implying the need for precise control of its expression. BB expression mirrors proliferative activity, yet the gene functions to limit proliferation, suggesting that it acts in an incoherent feedforward loop downstream of growth activators to prevent over-proliferation. Results To investigate the upstream regulation of BB we combined a promoter deletion analysis with a phylogenetic footprinting approach. We were able to narrow down important, highly conserved, cis-regulatory elements within the BB promoter. Promoter sequences of other Brassicaceae species were able to partially complement the A. thaliana bb-1 mutant, suggesting that at least within the Brassicaceae family the regulatory pathways are conserved. Conclusions This work underlines the complexity involved in precise quantitative control of gene expression and lays the foundation for identifying important upstream regulators that determine BB expression levels and thus final organ size.

  11. Contributions of vitamin D response elements and HLA promoters to multiple sclerosis risk.

    Science.gov (United States)

    Nolan, David; Castley, Alison; Tschochner, Monika; James, Ian; Qiu, Wei; Sayer, David; Christiansen, Frank T; Witt, Campbell; Mastaglia, Frank; Carroll, William; Kermode, Allan

    2012-08-07

    The identification of a vitamin D-responsive (VDRE) motif within the HLA-DRB1*15:01 promoter region provides an attractive explanation for the combined effects of HLA-DR inheritance and vitamin D exposure on multiple sclerosis (MS) risk. We therefore sought to incorporate HLA-DRB1 promoter variation, including the VDRE motif, in an assessment of HLA-DRB1-associated MS risk. We utilized 32 homozygous HLA cell lines (covering 17 DRB1 alleles) and 53 heterozygote MS samples (20 DRB1 alleles) for HLA-DRB1 promoter sequencing. The influence of HLA-DRB1 variation on MS risk was then assessed among 466 MS cases and 498 controls. The majority of HLA*DRB1 alleles (including HLA-DRB1*15:01) express the functional VDRE motif, apart from HLA-DRB1*04, *07, and *09 alleles that comprise the HLA-DR53 serologic group. Allele-specific variation within functional X-box and Y-box motifs was also associated with serologically defined HLA-DR haplotypes. Incorporating these results in an analysis of MS risk, we identified a strong protective effect of HLA-DRB1*04, *07, and *09 (DR53) alleles (p = 10(-12)) and elevated risk associated with DRB1*15 and *16 (DR51) and *08 (DR8) alleles (p < 10(-18)). HLA-DRB1 groups corresponding to serologic HLA-DR profiles as well as promoter polymorphism haplotypes effectively stratified MS risk over an 11-fold range, suggesting functional relationships between risk-modifying HLA-DRB1 alleles. An independent contribution of VDRE motif variation to increase MS risk was not discernible, although vitamin D-dependent regulation of HLA-DR expression may still play an important role given that HLA-DRB1*04/*07/*09 (DR53) alleles that express the "nonresponsive" VDRE motif were associated with significantly reduced risk of MS.

  12. The LHC SSS cold mass inside the cryostat. The complexity of the bus-bars for the power supply of the magnets and cryogenic links can be seen. The two apertures in the centre will house the beam lines

    CERN Document Server

    2003-01-01

    The LHC SSS cold mass inside the cryostat. The complexity of the bus-bars for the power supply of the magnets and cryogenic links can be seen. The two apertures in the centre will house the beam lines

  13. A geometric buckling expression for regular polygons: II. Analyses based on the multiple reciprocity boundary element method

    International Nuclear Information System (INIS)

    Itagaki, Masafumi; Miyoshi, Yoshinori; Hirose, Hideyuki

    1993-01-01

    A procedure is presented for the determination of geometric buckling for regular polygons. A new computation technique, the multiple reciprocity boundary element method (MRBEM), has been applied to solve the one-group neutron diffusion equation. The main difficulty in applying the ordinary boundary element method (BEM) to neutron diffusion problems has been the need to compute a domain integral, resulting from the fission source. The MRBEM has been developed for transforming this type of domain integral into an equivalent boundary integral. The basic idea of the MRBEM is to apply repeatedly the reciprocity theorem (Green's second formula) using a sequence of higher order fundamental solutions. The MRBEM requires discretization of the boundary only rather than of the domain. This advantage is useful for extensive survey analyses of buckling for complex geometries. The results of survey analyses have indicated that the general form of geometric buckling is B g 2 = (a n /R c ) 2 , where R c represents the radius of the circumscribed circle of the regular polygon under consideration. The geometric constant A n depends on the type of regular polygon and takes the value of π for a square and 2.405 for a circle, an extreme case that has an infinite number of sides. Values of a n for a triangle, pentagon, hexagon, and octagon have been calculated as 4.190, 2.281, 2.675, and 2.547, respectively

  14. Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci.

    Science.gov (United States)

    Canver, Matthew C; Lessard, Samuel; Pinello, Luca; Wu, Yuxuan; Ilboudo, Yann; Stern, Emily N; Needleman, Austen J; Galactéros, Frédéric; Brugnara, Carlo; Kutlar, Abdullah; McKenzie, Colin; Reid, Marvin; Chen, Diane D; Das, Partha Pratim; A Cole, Mitchel; Zeng, Jing; Kurita, Ryo; Nakamura, Yukio; Yuan, Guo-Cheng; Lettre, Guillaume; Bauer, Daniel E; Orkin, Stuart H

    2017-04-01

    Cas9-mediated, high-throughput, saturating in situ mutagenesis permits fine-mapping of function across genomic segments. Disease- and trait-associated variants identified in genome-wide association studies largely cluster at regulatory loci. Here we demonstrate the use of multiple designer nucleases and variant-aware library design to interrogate trait-associated regulatory DNA at high resolution. We developed a computational tool for the creation of saturating-mutagenesis libraries with single or multiple nucleases with incorporation of variants. We applied this methodology to the HBS1L-MYB intergenic region, which is associated with red-blood-cell traits, including fetal hemoglobin levels. This approach identified putative regulatory elements that control MYB expression. Analysis of genomic copy number highlighted potential false-positive regions, thus emphasizing the importance of off-target analysis in the design of saturating-mutagenesis experiments. Together, these data establish a widely applicable high-throughput and high-resolution methodology to identify minimal functional sequences within large disease- and trait-associated regions.

  15. Multiple cis-regulatory elements are involved in the complex regulation of the sieve element-specific MtSEO-F1 promoter from Medicago truncatula.

    Science.gov (United States)

    Bucsenez, M; Rüping, B; Behrens, S; Twyman, R M; Noll, G A; Prüfer, D

    2012-09-01

    The sieve element occlusion (SEO) gene family includes several members that are expressed specifically in immature sieve elements (SEs) in the developing phloem of dicotyledonous plants. To determine how this restricted expression profile is achieved, we analysed the SE-specific Medicago truncatula SEO-F1 promoter (PMtSEO-F1) by constructing deletion, substitution and hybrid constructs and testing them in transgenic tobacco plants using green fluorescent protein as a reporter. This revealed four promoter regions, each containing cis-regulatory elements that activate transcription in SEs. One of these segments also contained sufficient information to suppress PMtSEO-F1 transcription in the phloem companion cells (CCs). Subsequent in silico analysis revealed several candidate cis-regulatory elements that PMtSEO-F1 shares with other SEO promoters. These putative sieve element boxes (PSE boxes) are promising candidates for cis-regulatory elements controlling the SE-specific expression of PMtSEO-F1. © 2012 German Botanical Society and The Royal Botanical Society of the Netherlands.

  16. TU-H-BRA-07: Design, Construction, and Installation of An Experimental Beam Line for the Development of MRI-Linac Compatible Electron Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Whelan, B; Keall, P [University of Sydney, Sydney (Australia); Holloway, L [Liverpool Hospital and Ingham Institute, Liverpool, NSW (United Kingdom); Gierman, S; Schmerge, J; Tantawi, S; Tremaine, A; Trautwein, A; Scott, B [Stanford Linear Accelerator Facility, Palo Alto, CA (United States); Fahrig, R [Siemens Healthcare GmbH, Forchheim (Germany)

    2016-06-15

    Purpose: MRI guided radiation therapy (MRIgRT) is a rapidly growing field; however, Linac operation in MRI fringe fields represents an ongoing challenge. We have previously shown in-silico that Linacs could be redesigned to function in the in-line orientation with no magnetic shielding by adopting an RF-gun configuration. Other authors have also published insilico studies of Linac operation in magnetic fields; however to date no experimental validation data is published. This work details the design, construction, and installation of an experimental beam line to validate our in-silico results. Methods: An RF-gun comprising 1.5 accelerating cells and capable of generating electron energies up to 3.2MeV is used. The experimental apparatus was designed to monitor both beam current (toroid current monitor), spot size (two phosphor screens with viewports), and generate peak magnetic fields of at least 1000G (three variable current electromagnetic coils). Thermal FEM simulations were developed to ensure coil temperature remained within 100degC. Other design considerations included beam disposal, vacuum maintenance, radiation shielding, earthquake safety, and machine protection interlocks. Results: The beam line has been designed, built, and installed in a radiation shielded bunker. Water cooling, power supplies, thermo-couples, cameras, and radiation shielding have been successfully connected and tested. Interlock testing, vacuum processing, and RF processing have been successfully completed. The first beam on is expected within weeks. The coil heating simulations show that with care, peak fields of up to 1200G (320G at cathode) can be produced using 40A current, which is well within the fields expected for MRI-Linac systems. The maximum coil temperature at this current was 84degC after 6 minutes. Conclusion: An experimental beam line has been constructed and installed at SLAC in order to experimentally characterise RF gun performance in in-line magnetic fields, validate

  17. TU-H-BRA-07: Design, Construction, and Installation of An Experimental Beam Line for the Development of MRI-Linac Compatible Electron Accelerator

    International Nuclear Information System (INIS)

    Whelan, B; Keall, P; Holloway, L; Gierman, S; Schmerge, J; Tantawi, S; Tremaine, A; Trautwein, A; Scott, B; Fahrig, R

    2016-01-01

    Purpose: MRI guided radiation therapy (MRIgRT) is a rapidly growing field; however, Linac operation in MRI fringe fields represents an ongoing challenge. We have previously shown in-silico that Linacs could be redesigned to function in the in-line orientation with no magnetic shielding by adopting an RF-gun configuration. Other authors have also published insilico studies of Linac operation in magnetic fields; however to date no experimental validation data is published. This work details the design, construction, and installation of an experimental beam line to validate our in-silico results. Methods: An RF-gun comprising 1.5 accelerating cells and capable of generating electron energies up to 3.2MeV is used. The experimental apparatus was designed to monitor both beam current (toroid current monitor), spot size (two phosphor screens with viewports), and generate peak magnetic fields of at least 1000G (three variable current electromagnetic coils). Thermal FEM simulations were developed to ensure coil temperature remained within 100degC. Other design considerations included beam disposal, vacuum maintenance, radiation shielding, earthquake safety, and machine protection interlocks. Results: The beam line has been designed, built, and installed in a radiation shielded bunker. Water cooling, power supplies, thermo-couples, cameras, and radiation shielding have been successfully connected and tested. Interlock testing, vacuum processing, and RF processing have been successfully completed. The first beam on is expected within weeks. The coil heating simulations show that with care, peak fields of up to 1200G (320G at cathode) can be produced using 40A current, which is well within the fields expected for MRI-Linac systems. The maximum coil temperature at this current was 84degC after 6 minutes. Conclusion: An experimental beam line has been constructed and installed at SLAC in order to experimentally characterise RF gun performance in in-line magnetic fields, validate

  18. Non-LTR R2 element evolutionary patterns: phylogenetic incongruences, rapid radiation and the maintenance of multiple lineages.

    Directory of Open Access Journals (Sweden)

    Andrea Luchetti

    Full Text Available Retrotransposons of the R2 superclade specifically insert within the 28S ribosomal gene. They have been isolated from a variety of metazoan genomes and were found vertically inherited even if their phylogeny does not always agree with that of the host species. This was explained with the diversification/extinction of paralogous lineages, being proved the absence of horizontal transfer. We here analyze the widest available collection of R2 sequences, either newly isolated from recently sequenced genomes or drawn from public databases, in a phylogenetic framework. Results are congruent with previous analyses, but new important issues emerge. First, the N-terminal end of the R2-B clade protein, so far unknown, presents a new zinc fingers configuration. Second, the phylogenetic pattern is consistent with an ancient, rapid radiation of R2 lineages: being the estimated time of R2 origin (850-600 Million years ago placed just before the metazoan Cambrian explosion, the wide element diversity and the incongruence with the host phylogeny could be attributable to the sudden expansion of available niches represented by host's 28S ribosomal genes. Finally, we detect instances of coexisting multiple R2 lineages showing a non-random phylogenetic pattern, strongly similar to that of the "library" model known for tandem repeats: a collection of R2s were present in the ancestral genome and then differentially activated/repressed in the derived species. Models for activation/repression as well as mechanisms for sequence maintenance are also discussed within this framework.

  19. Double Emittance Exchanger as a Bunch Compressor for the MaRIE XFEL electron beam line at 1GeV

    Energy Technology Data Exchange (ETDEWEB)

    Malyzhenkov, Alexander [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Northern Illinois Univ., DeKalb, IL (United States); Yampolsky, Nikolai [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Carlsten, Bruce Eric [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-09-22

    We demonstrate an alternative realization of a bunch compressor (specifically the second bunch compressor for the MaRIE XFEL beamline, 1GeV electron energy) using a double emittance exchanger (EEX) and a telescope in the transverse phase space.We compare our results with a traditional bunch compressor realized via chicane, taking into account the nonlinear dynamics, Coherent Synchrotron Radiation (CSR) and Space Charge (SC) effects. In particular, we use the Elegant code for tracking particles through the beam line and analyze the eigen-emittances evolution to separate the influence of the CSR/SC effects from the nonlinear dynamics effects. We optimize the scheme parameters to reach a desirable compression factor and minimize the emittance growth. We observe dominant CSR-effects in our scheme resulting in critical emittance growth and introduce alternative version of an emittance exchanger with a reduced number of bending magnets to minimize the impact of CSR effects.

  20. Operation of beam line facilities for real-time x-ray studies at Sector 7 of the advanced photon source. Final Report

    International Nuclear Information System (INIS)

    Clarke, Roy

    2003-01-01

    This Final Report documents the research accomplishments achieved in the first phase of operations of a new Advanced Photon Source beam line (7-ID MHATT-CAT) dedicated to real-time x-ray studies. The period covered by this report covers the establishment of a world-class facility for time-dependent x-ray studies of materials. During this period many new and innovative research programs were initiated at Sector 7 with support of this grant, most notably using a combination of ultrafast lasers and pulsed synchrotron radiation. This work initiated a new frontier of materials research: namely, the study of the dynamics of materials under extreme conditions of high intensity impulsive laser irradiation

  1. Evaluation of the Shielding Performance for the Hot-cell built in 100-MeV Isotope Beam-line of KOMAC

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jeong Min; Park, Sung Kyun; Min, Yi Sub; Cho, Yong Sub [KAERI, Daejeon (Korea, Republic of)

    2016-05-15

    This study describes the structure of the hot-cell constructed in KOMAC for radioisotope production and evaluates the shielding performance for the hot-cell via the radiation shielding ability test. Korea multi-purpose accelerator complex (KOMAC) is currently operating 20-MeV and 100-MeV beam-line one by on. Additional 100-MeV beam-line and target room (TR101) are planned for the purpose of the radioisotope production in this year. The initial goal of the radioisotope production is to produce the radioactive isotopes, Sr-82 or Cu-67, used widely for the diagnosis and treatment of the cancer. In order to produce these radioisotopes mentioned, the proton beam with the energy between 70-MeV and 100- MeV at a beam current of 300 μA is irradiated into a solid target made of ZnO or RbCl. After the irradiation of the proton beam during approximately 100 hours, the radioisotope Sr-82 with the radioactivity amount of about 3.8 Ci or the Cu-67 with the amount of about 2.7 Ci will be produced. Radioisotopes produced though this process should be conveyed from the TR101 target room to the PR101 processing room and then in order to be delivered into the place for the next process step, a hot-cell is necessary. Result of the shielding performance evaluation of the hot-cell for producing radioisotopes shows the necessity of the shield reinforcement using lead material at side of the lead glass window.

  2. Contributions to multiple element speciation in vegetable plants: Studies on the type of bonding of numerous elements, particularly zinc and cadmium

    International Nuclear Information System (INIS)

    Guenther, K.

    1997-03-01

    In the first part of the study, the total contents and the solubility characteristics of Zn, Cd, Fe, Mn, Cu, Ca, Sr, K and Rb in 26 different vegetable plants, the majority of them commercially available, are reported, obtained by post-decomposition analyses. The data are given for avocados, bananas, cauliflower, chicory, Chinese cabbage, dill, ice lettuce (two specimens), endive, field salad, cucumbers, kohlrabi, lettuce, chard beet, carrots, peppers, leek, radish, red cabbage, loose leaved lettuce, celery (two specimens), spinach, topinambur, white cabbage, and parsley. Cell decomposition was done by treatment of the plant material with an electric dispersing apparatus (Ultra-Turrax) in buffer solution (liquid shearing). The homogenates were separated into supernatants (cytosoles)and pellets by means of centrifugation. Cell decomposition of the plants by crushing with quartz sand after lyophilization (solid shearing) required much more technical effort and for some elements created problems with the blind values. At least 50% on the average of the elements Zn, Cd, Rb, and K could be transferred to the solutions by the dispersing treatment with Ultra-Turrax. In many cases, the cytosole-borne detectable contents of these 5 elements were above 70%. The solubility of Zn and Cd was more strongly dependent on the plant species than that of Cu, Rb, and K. All five elements thus can be analysed by conventional methods for further enhanced speciation. Mn, Ca, and especially Fe and Sr for the most part were found to be bonded to solid cell constituents. However, the solubility characteristics of Ca and Mn and Sr in particular was very homogeneous. In some plants, the contents of Mn and Sr in the cytosoles was approx. 90%, so that comprehensive speciation of these elements is possible. (orig./AJ) [de

  3. Overcoming Matrix Effects in a Complex Sample: Analysis of Multiple Elements in Multivitamins by Atomic Absorption Spectroscopy

    Science.gov (United States)

    Arnold, Randy J.; Arndt, Brett; Blaser, Emilia; Blosser, Chris; Caulton, Dana; Chung, Won Sog; Fiorenza, Garrett; Heath, Wyatt; Jacobs, Alex; Kahng, Eunice; Koh, Eun; Le, Thao; Mandla, Kyle; McCory, Chelsey; Newman, Laura; Pithadia, Amit; Reckelhoff, Anna; Rheinhardt, Joseph; Skljarevski, Sonja; Stuart, Jordyn; Taylor, Cassie; Thomas, Scott; Tse, Kyle; Wall, Rachel; Warkentien, Chad

    2011-01-01

    A multivitamin tablet and liquid are analyzed for the elements calcium, magnesium, iron, zinc, copper, and manganese using atomic absorption spectrometry. Linear calibration and standard addition are used for all elements except calcium, allowing for an estimate of the matrix effects encountered for this complex sample. Sample preparation using…

  4. Study of the CNGS beam and identification of muons in the Opera experiment. Optimization of the beam line from SPL-Frejus project; Etude du faisceau CNGS et identification des muons dans l'experience OPERA. Optimisation de la ligne de faisceau du projet SPL-Frejus

    Energy Technology Data Exchange (ETDEWEB)

    Cazes, A

    2004-12-15

    Neutrino oscillations are the subject of most of the experiments looking at this particle. This mechanism uses the fact that neutrinos have mass to allow the transformation from one flavour to another one. The OPERA experiment will start to take data in spring 2006. Its goal is to proof this mechanism with no ambiguity using the appearance of tau neutrinos in the CNGS beam, which is made of muon neutrinos. This thesis presents a description of neutrino beams in general, and more precisely of the CNGS beam, which is sent from CERN to Gran Sasso in Italy. The neutrino flux are recalculated, and simulations have been performed in order to study miss positioning of the beam line elements. The OPERA detector is made of bricks containing a pile of lead plates and photographic emulsion films, of two trackers and two spectrometers. The high position resolution of the emulsions (< 1 {mu}m ), allows to identify the {tau} created by the tau neutrino charged current interactions. The brick localisation is made using a scintillator array. The pattern recognition in these scintillators as well as in the spectrometers is one of the part of this thesis. Furthermore, a muon identification algorithm has been set up. It allows to reject by a factor 20 the charm background. Future of neutrino oscillation physics is the building of more and more intense neutrino beams, in order to measure the last unknown parameters ({theta}{sub 13} and {delta}{sub CP}). The project of neutrino beam from CERN to the Fr us tunnel is fully revisited in the last part of this thesis. An optimisation of all the beam line element is proposed, and allows to reach a sensitivity to {theta}{sub 13} around one degree. (author)

  5. Overview of multi-element monolithic germanium detectors for XAFS experiments at diamond light source

    International Nuclear Information System (INIS)

    Chatterji, S.; Dennis, G. J.; Dent, A.; Diaz-Moreno, S.; Cibin, G.; Tartoni, N.; Helsby, W. I.

    2016-01-01

    An overview of multi-element monolithic germanium detectors being used at the X-ray absorption spectroscopy (XAS) beam lines at Diamond Light Source (DLS) is being reported. The hardware details and a summary of the performance of these detectors have also been provided. Recent updates about various ongoing projects being worked on to improve the performance of these detectors are summarized.

  6. Overview of multi-element monolithic germanium detectors for XAFS experiments at diamond light source

    Energy Technology Data Exchange (ETDEWEB)

    Chatterji, S.; Dennis, G. J.; Dent, A.; Diaz-Moreno, S.; Cibin, G.; Tartoni, N. [Diamond Light Source Ltd, Oxfordshire (United Kingdom); Helsby, W. I. [STFC Daresbury Laboratory, Warrington (United Kingdom)

    2016-07-27

    An overview of multi-element monolithic germanium detectors being used at the X-ray absorption spectroscopy (XAS) beam lines at Diamond Light Source (DLS) is being reported. The hardware details and a summary of the performance of these detectors have also been provided. Recent updates about various ongoing projects being worked on to improve the performance of these detectors are summarized.

  7. POTENTIALLY TOXIC ELEMENT CYCLES AND CHARACTERIZATION OF MULTIPLE SOURCES IN THE IRRIGATION DITCHES FROM THE RAVENNA COASTAL PLAIN THROUGH TRACE ELEMENTS AND ISOTOPE GEOCHEMISTRY

    Directory of Open Access Journals (Sweden)

    Livia Vittori Antisari

    2010-04-01

    Full Text Available While monitoring the physico-chemical characteristics, trace elements and O-H-Sr-B isotopic data were obtained in superficial waters from a number of irrigations canals and ditches in the Ravenna coastal plain, in order to highlight the cycling of potentially toxic elements and the different sources of the solutes. Surveys were conducted during March and July 2008, and considered as representative of the waters in winter and summer, respectively. In summer, the water mass balance in the network is mostly controlled by the ingression of freshwaters from the Canale Emiliano Romagnolo (CER. The O-H isotopic data indicated that, in winter, waters are primarily recharged from Apennine catchments and undergo evaporation to different extents.The boron isotopic signature indicates the important role played by the marine component. A major seawater contribution was evidenced in canals close to the coastline; however, the process controlling the origin of dissolved boron is not solely related to direct mixing with sea water but comprises an additional source probably related to water-soil exchanges and boron of marine origin leaching, owing to the prolonged exposure of alluvial sediments to sea water. An additional boron contribution from the agricultural practice was is also evidenced. Calculation based on the conservative behaviour of chloride ions indicated that in canals and ditches not directly connected with the sea up to the 80% of the Sr budget did not originate from seawater, indicating a source from Al-silicate minerals and supporting the hypothesis of significant soil-water interactions and chemical exchanges.The positive correlation between pH and dissolved oxygen in winter waters is likely to reflect CO2 consumption during algal photosynthesis, favouring the in-situ generation of colloidal particles due to the oxidative precipitation of ferric iron oxy-hydroxides and probably small carbonate particles able to adsorb trace metals on their

  8. Development of an x-ray beam line at the NSLS for studies in materials science using x-ray absorption spectroscopy

    International Nuclear Information System (INIS)

    Sayers, D.E.

    1989-01-01

    At the time of the submission of the original proposal more than 7 years ago, the X-11 PRT had set as a goal to develop one of the leading and most comprehensive x-ray absorption beam lines in the world. By any measure we have been successful. As is well documented in previous annual progress report and in the NSLS annual reports, our PRT has been extremely productive in a wide range of topics in materials science, solid state physics, chemistry and biology. Well over 100 papers have been published acknowledging the support of this contract and this continues at a rate of about 30 papers per year and about 20 invited presentations per year. Significant in this report are major studies in high T c compounds, advances in interface studies, new results in premelting phenomena, several pioneering studies in application of XAS to electrochemistry and significant progress in our understanding of the structure of amorphous chalcogenide systems and their photostructural changes

  9. Final Technical Report on STTR Project DE-FG02-06ER86281 Particle Tracking in Matter-Dominated Beam Lines (G4beamline)

    Energy Technology Data Exchange (ETDEWEB)

    Muons, Inc.

    2011-05-19

    This project has been for software development of the G4beamline [1] program, which is a particle-tracking simulation program based on the Geant4 toolkit [2], optimized for beam lines. This program can perform more realistic simulations than most alternatives, while being significantly easier to use by physicists. This project has fostered the general acceptance of G4beamline within the muon community, and has assisted in expanding its role outside that community. During this project, the G4beamline user community has grown from about a half-dozen users to more than 200 users around the world. This project also validated our business decision to keep G4beamline an open-source program, judging that an STTR project would provide more development resources than would marketing and selling the program. G4beamline is freely available to the physics community, and has been well validated against experiments and other codes within its domain. Muons, Inc. continues to support and develop the program, and a major part of the company's continued success and growth is directly related to our expertise in applying this program to interesting applications.

  10. The mitochondrial genomes of sponges provide evidence for multiple invasions by Repetitive Hairpin-forming Elements (RHE

    Directory of Open Access Journals (Sweden)

    Lavrov Dennis V

    2009-12-01

    Full Text Available Abstract Background The mitochondrial (mt genomes of sponges possess a variety of features, which appear to be intermediate between those of Eumetazoa and non-metazoan opisthokonts. Among these features is the presence of long intergenic regions, which are common in other eukaryotes, but generally absent in Eumetazoa. Here we analyse poriferan mitochondrial intergenic regions, paying particular attention to repetitive sequences within them. In this context we introduce the mitochondrial genome of Ircinia strobilina (Lamarck, 1816; Demospongiae: Dictyoceratida and compare it with mtDNA of other sponges. Results Mt genomes of dictyoceratid sponges are identical in gene order and content but display major differences in size and organization of intergenic regions. An even higher degree of diversity in the structure of intergenic regions was found among different orders of demosponges. One interesting observation made from such comparisons was of what appears to be recurrent invasions of sponge mitochondrial genomes by repetitive hairpin-forming elements, which cause large genome size differences even among closely related taxa. These repetitive hairpin-forming elements are structurally and compositionally divergent and display a scattered distribution throughout various groups of demosponges. Conclusion Large intergenic regions of poriferan mt genomes are targets for insertions of repetitive hairpin- forming elements, similar to the ones found in non-metazoan opisthokonts. Such elements were likely present in some lineages early in animal mitochondrial genome evolution but were subsequently lost during the reduction of intergenic regions, which occurred in the Eumetazoa lineage after the split of Porifera. Porifera acquired their elements in several independent events. Patterns of their intra-genomic dispersal can be seen in the mt genome of Vaceletia sp.

  11. Matrix elements of the electric multiple transition and relativistic correction operators in the case of complex configurations

    International Nuclear Information System (INIS)

    Kanyauskas, Yu.M.; Rudzikas, Z.B.

    1976-01-01

    Operators and their submatrix elements are studied in the framework of the electric multipole transitions of complex atoms with account of relativistic corrections of the order of the square of the fine structure constant. The analysis is performed by means of irreducible tensor operators and genealogical coefficients. It has been assumed that angular momenta of individual shells are coupled with each other according to ls, lk, jk and jj coupling. Formulas are given for the operator which causes the relativistic corrections for the single-electron multipole transition and for its submatrix element in the case of configurations with two unfilled shells. A possibility is discussed of using the formulas suggested for calculation. As follows from analysis, the relativistic correction operators even with the pure ls coupling allow intercombination transitions with ΔS equals +-1. The expressions obtained may turn out to be useful for performing calculations in the case of the intermediate type of coupling

  12. Beam line to S155

    CERN Multimedia

    1977-01-01

    The experiment S155 was designed by the Orsay (CSNM-CNRS) Collaboration to observe the properties of exotic light nuclei. It was installed in the PS neutrino tunnel. The photo shows a mass spectrometer (in the background) on line with the PS proton beam which arrives (bottom, right) from the fast extraction FE74. Roger Fergeau stands on the left. The alkaline isotopes produced in the carbon-uranium target heated at 2000°C were swiftly extracted, mass separated, and brought to a detector behind the shielding. Sodium 34 (11 protons and 23 neutrons) was observed and its half-life of only 5 ms was measured. The excited levels 2+ of Magnesium 30 and Magnesium 32 (Sodium descendants) were localised, and the magic number 20 was found to vanish. Thus, the discovery made earlier for Sodium 30 and Sodium 32, with the same apparatus, was confirmed. (See also photo 7706511.)

  13. Straight scaling FFAG beam line

    International Nuclear Information System (INIS)

    Lagrange, J.-B.; Planche, T.; Yamakawa, E.; Uesugi, T.; Ishi, Y.; Kuriyama, Y.; Qin, B.; Okabe, K.; Mori, Y.

    2012-01-01

    Fixed field alternating gradient (FFAG) accelerators are recently subject to a strong revival. They are usually designed in a circular shape; however, it would be an asset to guide particles with no overall bend in this type of accelerator. An analytical development of a straight FFAG cell which keeps zero-chromaticity is presented here. A magnetic field law is thus obtained, called “straight scaling law”, and an experiment has been conducted to confirm this zero-chromatic law. A straight scaling FFAG prototype has been designed and manufactured, and horizontal phase advances of two different energies are measured. Results are analyzed to clarify the straight scaling law.

  14. A beam line to inspire

    CERN Multimedia

    2014-01-01

    Just as the sunshine seems to have arrived back at CERN, in other respects summer is coming to a close as we say our farewells to this year’s crop of summer students. This injection of young people – always a welcome feature in July and August at CERN – dates back to the early 1960s, when the Summer Student programme began under one of my predecessors Vicky Weisskopf.   The idea was to awaken the interest of undergraduates in CERN's activities by offering them the chance of hands-on experience during their long summer vacation. Around the same time, the CERN School of Physics began. Aimed at young postgraduates, it led to the current European School of High-Energy Physics and related schools in Latin America and the Asia-Pacific region. Over the years, it was joined by CERN schools on accelerator subjects and computing, which have expanded CERN’s training mandate. These days, our efforts begin with young people before they go to university &...

  15. Straight scaling FFAG beam line

    Science.gov (United States)

    Lagrange, J.-B.; Planche, T.; Yamakawa, E.; Uesugi, T.; Ishi, Y.; Kuriyama, Y.; Qin, B.; Okabe, K.; Mori, Y.

    2012-11-01

    Fixed field alternating gradient (FFAG) accelerators are recently subject to a strong revival. They are usually designed in a circular shape; however, it would be an asset to guide particles with no overall bend in this type of accelerator. An analytical development of a straight FFAG cell which keeps zero-chromaticity is presented here. A magnetic field law is thus obtained, called "straight scaling law", and an experiment has been conducted to confirm this zero-chromatic law. A straight scaling FFAG prototype has been designed and manufactured, and horizontal phase advances of two different energies are measured. Results are analyzed to clarify the straight scaling law.

  16. Resveratrol stimulates c-Fos gene transcription via activation of ERK1/2 involving multiple genetic elements.

    Science.gov (United States)

    Thiel, Gerald; Rössler, Oliver G

    2018-06-05

    The polyphenol resveratrol is found in many plant and fruits and is a constituent of our diet. Resveratrol has been proposed to have chemopreventive and anti-inflammatory activities. On the cellular level, resveratrol activates stimulus-regulated transcription factors. To identify resveratrol-responsive elements within a natural gene promoter, the molecular pathway leading to c-Fos gene expression by resveratrol was dissected. The c-Fos gene encodes a basic region leucine zipper transcription factor and is a prototype of an immediate-early gene that is regulated by a wide range of signaling molecules. We analyzed chromatin-integrated c-Fos promoter-luciferase reporter genes where transcription factor binding sites were destroyed by point mutations or deletion mutagenesis. The results show that mutation of the binding sites for serum response factor (SRF), activator protein-1 (AP-1) and cAMP response element binding protein (CREB) significantly reduced reporter gene transcription following stimulation of the cells with resveratrol. Inactivation of the binding sites for signal transducer and activator of transcription (STAT) or ternary complex factors did not influence resveratrol-regulated c-Fos promoter activity. Thus, the c-Fos promoter contains three resveratrol-responsive elements, the cAMP response element (CRE), and the binding sites for SRF and AP-1. Moreover, we show that the transcriptional activation potential of the c-Fos protein is increased in resveratrol-stimulated cells, indicating that the biological activity of c-Fos is elevated by resveratrol stimulation. Pharmacological and genetic experiments revealed that the protein kinase ERK1/2 is the signal transducer that connects resveratrol treatment with the c-Fos gene. Copyright © 2018 Elsevier B.V. All rights reserved.

  17. 3D Space Shift from CityGML LoD3-Based Multiple Building Elements to a 3D Volumetric Object

    Directory of Open Access Journals (Sweden)

    Shen Ying

    2017-01-01

    Full Text Available In contrast with photorealistic visualizations, urban landscape applications, and building information system (BIM, 3D volumetric presentations highlight specific calculations and applications of 3D building elements for 3D city planning and 3D cadastres. Knowing the precise volumetric quantities and the 3D boundary locations of 3D building spaces is a vital index which must remain constant during data processing because the values are related to space occupation, tenure, taxes, and valuation. To meet these requirements, this paper presents a five-step algorithm for performing a 3D building space shift. This algorithm is used to convert multiple building elements into a single 3D volumetric building object while maintaining the precise volume of the 3D space and without changing the 3D locations or displacing the building boundaries. As examples, this study used input data and building elements based on City Geography Markup Language (CityGML LoD3 models. This paper presents a method for 3D urban space and 3D property management with the goal of constructing a 3D volumetric object for an integral building using CityGML objects, by fusing the geometries of various building elements. The resulting objects possess true 3D geometry that can be represented by solid geometry and saved to a CityGML file for effective use in 3D urban planning and 3D cadastres.

  18. Optimized computational method for determining the beta dose distribution using a multiple-element thermoluminescent dosimeter system

    International Nuclear Information System (INIS)

    Shen, L.; Levine, S.H.; Catchen, G.L.

    1987-01-01

    This paper describes an optimization method for determining the beta dose distribution in tissue, and it describes the associated testing and verification. The method uses electron transport theory and optimization techniques to analyze the responses of a three-element thermoluminescent dosimeter (TLD) system. Specifically, the method determines the effective beta energy distribution incident on the dosimeter system, and thus the system performs as a beta spectrometer. Electron transport theory provides the mathematical model for performing the optimization calculation. In this calculation, parameters are determined that produce calculated doses for each of the chip/absorber components in the three-element TLD system. The resulting optimized parameters describe an effective incident beta distribution. This method can be used to determine the beta dose specifically at 7 mg X cm-2 or at any depth of interest. The doses at 7 mg X cm-2 in tissue determined by this method are compared to those experimentally determined using an extrapolation chamber. For a great variety of pure beta sources having different incident beta energy distributions, good agreement is found. The results are also compared to those produced by a commonly used empirical algorithm. Although the optimization method produces somewhat better results, the advantage of the optimization method is that its performance is not sensitive to the specific method of calibration

  19. Multiple enrichment of the Carpathian-Pannonian mantle: Pb-Sr-Nd isotope and trace element constraints

    Science.gov (United States)

    Rosenbaum, Jeffrey M.; Wilson, Marjorie; Downes, Hilary

    1997-07-01

    Pb isotope compositions of acid-leached clinopyroxene and amphibole mineral separates from spinel peridotite mantle xenoliths entrained in Tertiary-Quaternary alkali basalts from the Carpathian-Pannonian Region of eastern Europe provide important constraints on the processes of metasomatic enrichment of the mantle lithosphere in an extensional tectonic setting associated with recent subduction. Principal component analysis of Pb-Sr-Nd isotope and rare earth element compositions of the pyroxenes is used to identify the geochemical characteristics of the original lithospheric mantle protolith and a spectrum of infiltrating metasomatic agents including subduction-related aqueous fluids and silicate melts derived from a subduction-modified mantle wedge which contains a St. Helena-type (HIMU) plume component. The mantle protolith is highly depleted relative to mid-ocean ridge basalt-source mantle with Pb-Nd-Sr isotope compositions consistent with an ancient depletion event. Silicate melt infiltration into the protolith accounts for the primary variance in the Pb-Sr-Nd isotope compositions of the xenoliths and has locally generated metasomatic amphibole. Infiltration of aqueous fluids has introduced radiogenic Pb and Sr without significantly perturbing the rare earth element signature of the protolith. The Pb isotope compositions of the fluid-modified xenoliths suggest that they reacted with aqueous fluids released from a subduction zone which had equilibrated with sediment derived from an ancient basement terrain. We propose a model for mantle lithosphere evolution consistent with available textural and geochemical data for the xenolith population. The Pb-Sr-Nd isotope compositions of both alkaline mafic magmas and rare, subduction-related, calc-alkaline basaltic andesites from the region provide important constraints for the nature of the asthenospheric mantle wedge and confirm the presence of a HIMU plume component. These silicate melts contribute to the metasomatism

  20. New Insights into Trace Element Partitioning in Amphibole from Multiple Regression Analysis, with Application to the Magma Plumbing System of Mt. Lamington (Papua New Guinea)

    Science.gov (United States)

    Zhang, J.; Humphreys, M.; Cooper, G.; Davidson, J.; Macpherson, C.

    2015-12-01

    We present a new multiple regression (MR) analysis of published amphibole-melt trace element partitioning data, with the aim of retrieving robust relationships between amphibole crystal-chemical compositions and trace element partition coefficients (D). We examined experimental data for calcic amphiboles of kaersutite, pargasite, tschermakite (Tsch), magnesiohornblende (MgHbl) and magnesiohastingsite (MgHst) compositions crystallized from basanitic-rhyolitic melts (n = 150). The MR analysis demonstrates the varying significance of amphibole major element components assigned to different crystallographic sites (T, M1-3, M4, A) as independent variables in controlling D, and it allows us to retrieve statistically significant relationships for REE, Y, Rb, Sr, Pb, Ti, Zr, Nb (n > 25, R2 > 0.6, p-value Ridolfi & Renzulli 2012) with lower Rb and Sr and higher Pb, relative to a hot, andesitic-dacitic melt (950-1,000±50 ºC; 60-70±5 wt % SiO2) where MgHst are crystallized. REE and Nb contents are similar in both types of melts despite higher REE and Nb in MgHbl-Tsch. Therefore, the REE compositional disparity between MgHst and MgHbl-Tsch is driven by the difference in the DREE, rather than the melt REE concentrations.

  1. Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3.

    Science.gov (United States)

    Potvin, Eric; Beuret, Laurent; Cadrin-Girard, Jean-François; Carter, Marcelle; Roy, Sophie; Tremblay, Michel; Charron, Jean

    2010-11-01

    The precise expression of the N-myc proto-oncogene is essential for normal mammalian development, whereas altered N-myc gene regulation is known to be a determinant factor in tumor formation. Using transgenic mouse embryos, we show that N-myc sequences from kb -8.7 to kb +7.2 are sufficient to reproduce the N-myc embryonic expression profile in developing branchial arches and limb buds. These sequences encompass several regulatory elements dispersed throughout the N-myc locus, including an upstream limb bud enhancer, a downstream somite enhancer, a branchial arch enhancer in the second intron, and a negative regulatory element in the first intron. N-myc expression in the limb buds is under the dominant control of the limb bud enhancer. The expression in the branchial arches necessitates the interplay of three regulatory domains. The branchial arch enhancer cooperates with the somite enhancer region to prevent an inhibitory activity contained in the first intron. The characterization of the branchial arch enhancer has revealed a specific role of the transcription factor GATA3 in the regulation of N-myc expression. Together, these data demonstrate that correct N-myc developmental expression is achieved via cooperation of multiple positive and negative regulatory elements.

  2. Exchange pattern of gaseous elemental mercury in landfill: mercury deposition under vegetation coverage and interactive effects of multiple meteorological conditions.

    Science.gov (United States)

    Tao, Zhengkai; Liu, Yang; Zhou, Meng; Chai, Xiaoli

    2017-12-01

    Landfill is known as a potential source of atmospheric Hg and an important component of the local or regional atmospheric Hg budget. This study investigated the gaseous elemental Hg surface-air fluxes under differing conditions at a typical municipal solid waste landfill site, highlighting the interactive effects of plant coverage and meteorological conditions. The results indicated that Hg fluxes exhibited a feature represented by diel variation. In particular, Hg deposition was observed under a condition of Kochia sieversiana coverage, whereas emission that occurred after K. sieversiana was removed. Hg emission was the dominant mode under conditions of Setaria viridis coverage and its removal; however, the average Hg emission flux with the S. viridis coverage was nearly four times lower than after its removal. These findings verified that the plant coverage should be a key factor influencing the Hg emission from landfills. In addition, Hg fluxes were correlated positively with solar radiation and air/soil temperature and correlated inversely with relative humidity under all conditions, except K. sieversiana coverage. This suggested that the interactive effects of meteorological conditions and plant coverage played a jointly significant role in the Hg emission from landfills. It was established that K. sieversiana can inhibit Hg emission efficiently, and therefore, it could potentially be suitable for use as a plant-based method to control Hg pollution from landfills.

  3. Towards the prediction of multiple necking during dynamic extension of round bar: linear stability approach versus finite element calculations

    International Nuclear Information System (INIS)

    Maï, S El; Petit, J; Mercier, S; Molinari, A

    2014-01-01

    The fragmentation of structures subject to dynamic conditions is a matter of interest for civil industries as well as for Defence institutions. Dynamic expansions of structures, such as cylinders or rings, have been performed to obtain crucial information on fragment distributions. Many authors have proposed to capture by FEA the experimental distribution of fragment size by introducing in the FE model a perturbation. Stability and bifurcation analyses have also been proposed to describe the evolution of the perturbation growth rate. In the proposed contribution, the multiple necking of a round bar in dynamic tensile loading is analysed by the FE method. A perturbation on the initial flow stress is introduced in the numerical model to trigger instabilities. The onset time and the dominant mode of necking have been characterized precisely and showed power law evolutions, with the loading velocities and moderately with the amplitudes and the cell sizes of the perturbations. In the second part of the paper, the development of linear stability analysis and the use of salient criteria in terms of the growth rate of perturbations enabled comparisons with the numerical results. A good correlation in terms of onset time of instabilities and of number of necks is shown.

  4. Status of beam line detectors for the BigRIPS fragment separator at RIKEN RI Beam Factory. Issues on high rates and resolution

    International Nuclear Information System (INIS)

    Sato, Yuki; Fukuda, Naoki; Takeda, Hiroyuki

    2015-01-01

    A multiple sampling ionization chamber (MUSIC) and parallel-plate avalanche counters (PPACs) were installed within the superconducting in-flight separator, named BigRIPS, at the RIKEN Nishina Center for particle identification of RI beams. The MUSIC detector showed negligible charge collection inefficiency from recombination of electrons and ions, up to a 99-kcps incidence rate for high-energy heavy ions. For the PPAC detectors, the electrical discharge durability for incident heavy ions was improved by changing the electrode material. Finally, we designed a single crystal diamond detector, which is under development for TOF measurements of high-energy heavy ions, that has a very fast response time (pulse width <1 ns). (author)

  5. Status of Beam Line Detectors for the BigRIPS Fragment Separator at RIKEN RI Beam Factory: Issues on High Rates and Resolution

    Science.gov (United States)

    Sato, Yuki; Fukuda, Naoki; Takeda, Hiroyuki; Kameda, Daisuke; Suzuki, Hiroshi; Shimizu, Yohei; Ahn, DeukSoon; Murai, Daichi; Inabe, Naohito; Shimaoka, Takehiro; Tsubota, Masakatsu; Kaneko, Junichi H.; Chayahara, Akiyoshi; Umezawa, Hitoshi; Shikata, Shinichi; Kumagai, Hidekazu; Murakami, Hiroyuki; Sato, Hiromi; Yoshida, Koichi; Kubo, Toshiyuki

    A multiple sampling ionization chamber (MUSIC) and parallel-plate avalanche counters (PPACs) were installed within the superconducting in-flight separator, named BigRIPS, at the RIKEN Nishina Center for particle identification of RI beams. The MUSIC detector showed negligible charge collection inefficiency from recombination of electrons and ions, up to a 99-kcps incidence rate for high-energy heavy ions. For the PPAC detectors, the electrical discharge durability for incident heavy ions was improved by changing the electrode material. Finally, we designed a single crystal diamond detector, which is under development for TOF measurements of high-energy heavy ions, that has a very fast response time (pulse width <1 ns).

  6. Basic Finite Element Method

    International Nuclear Information System (INIS)

    Lee, Byeong Hae

    1992-02-01

    This book gives descriptions of basic finite element method, which includes basic finite element method and data, black box, writing of data, definition of VECTOR, definition of matrix, matrix and multiplication of matrix, addition of matrix, and unit matrix, conception of hardness matrix like spring power and displacement, governed equation of an elastic body, finite element method, Fortran method and programming such as composition of computer, order of programming and data card and Fortran card, finite element program and application of nonelastic problem.

  7. CERN News: Slow ejection efficiency at the PS; Vacuum tests on the ISR; Fire in the neutrino beam-line; Prototype r.f . cavity for the Booster; Crane-bridge in ISR experimental hall; Modifications to the r.f . system at the PS

    CERN Multimedia

    1969-01-01

    CERN News: Slow ejection efficiency at the PS; Vacuum tests on the ISR; Fire in the neutrino beam-line; Prototype r.f . cavity for the Booster; Crane-bridge in ISR experimental hall; Modifications to the r.f . system at the PS

  8. Multiple uses and regulation: elements for the sustain of the water resource systems; Usos multiplos e regulacao: elementos para a sustentabilidade dos sistemas de recursos hidricos

    Energy Technology Data Exchange (ETDEWEB)

    Salles, Lauriberto S. [Secretaria de Estado de Meio Ambiente, Sao Paulo, SP (Brazil). Dept. de Uso do Solo Metropolitano; Bermann, Celio [Sao Paulo Univ., SP (Brazil). Programa Interunidades de Pos-Graduacao em Energia

    1998-12-31

    National and State water resource management plans demand new patterns of relationships between water users and the society. Regarding water resources sustainability, this work appraises some aspects of the water Committee Basins policies related to multiple water uses, within the frame of the regulatory agencies proposed. (author) 4 refs.

  9. Lentiviral vectors containing mouse Csf1r control elements direct macrophage-restricted expression in multiple species of birds and mammals

    Directory of Open Access Journals (Sweden)

    Clare Pridans

    2014-01-01

    Full Text Available The development of macrophages requires signaling through the lineage-restricted receptor Csf1r. Macrophage-restricted expression of transgenic reporters based upon Csf1r requires the highly conserved Fms-intronic regulatory element (FIRE. We have created a lentiviral construct containing mouse FIRE and promoter. The lentivirus is capable of directing macrophage-restricted reporter gene expression in mouse, rat, human, pig, cow, sheep, and even chicken. Rat bone marrow cells transduced with the lentivirus were capable of differentiating into macrophages expressing the reporter gene in vitro. Macrophage-restricted expression may be desirable for immunization or immune response modulation, and for gene therapy for lysosomal storage diseases and some immunodeficiencies. The small size of the Csf1r transcription control elements will allow the insertion of large “cargo” for applications in gene therapy and vaccine delivery.

  10. Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccine.

    Science.gov (United States)

    Chuan, Yap P; Rivera-Hernandez, Tania; Wibowo, Nani; Connors, Natalie K; Wu, Yang; Hughes, Fiona K; Lua, Linda H L; Middelberg, Anton P J

    2013-09-01

    Modularization of a peptide antigen for presentation on a microbially synthesized murine polyomavirus (MuPyV) virus-like particle (VLP) offers a new alternative for rapid and low-cost vaccine delivery at a global scale. In this approach, heterologous modules containing peptide antigenic elements are fused to and displayed on the VLP carrier, allowing enhancement of peptide immunogenicity via ordered and densely repeated presentation of the modules. This study addresses two key engineering questions pertaining to this platform, exploring the effects of (i) pre-existing carrier-specific immunity on modular VLP vaccine effectiveness and (ii) increase in the antigenic element number per VLP on peptide-specific immune response. These effects were studied in a mouse model and with modular MuPyV VLPs presenting a group A streptococcus (GAS) peptide antigen, J8i. The data presented here demonstrate that immunization with a modular VLP could induce high levels of J8i-specific antibodies despite a strong pre-existing anti-carrier immune response. Doubling of the J8i antigenic element number per VLP did not enhance J8i immunogenicity at a constant peptide dose. However, the strategy, when used in conjunction with increased VLP dose, could effectively increase the peptide dose up to 10-fold, leading to a significantly higher J8i-specific antibody titer. This study further supports feasibility of the MuPyV modular VLP vaccine platform by showing that, in the absence of adjuvant, modularized GAS antigenic peptide at a dose as low as 150 ng was sufficient to raise a high level of peptide-specific IgGs indicative of bactericidal activity. Copyright © 2013 Wiley Periodicals, Inc.

  11. An electromagnetically focused electron beam line source

    International Nuclear Information System (INIS)

    Iqbal, Munawar; Masood, Khalid; Rafiq, Mohammad; Chaudhary, Maqbool A.; Aleem, Fazal-e-

    2003-01-01

    A directly heated thermionic electron beam source was constructed. A tungsten wire of length 140 mm with diameter 0.9 mm was used as a cathode. An emission current of 5000 mA was achieved at an input heating power of 600 W. Cathode to anode distance of 6 mm with acceleration voltage of 10 kV was used. A uniform external magnetic field of 50 G was employed to obtain a well-focused electron beam at a deflection of 180 deg., with cathode to work site distance of 130 mm. Dimensions of the beam (1.25x120 mm) recorded at the work site were found to be in good agreement with the designed length of cathode. The deformation of the cathode was overcome by introducing a spring action mechanism, which gives uniform emission current density throughout the emission surface. We have achieved the saturation limit of the designed source resulting in smooth and swift operation of the gun for many hours (10-15 h continuously). The design of gun is so simple that it can accommodate longer cathodes for obtaining higher emission values. This gun has made it possible to coat large substrate surfaces at much faster evaporation rate at lower cost. It can also be useful in large-scale vacuum metallurgy plants for melting, welding and heat treatment

  12. Degradation of YRA1 Pre-mRNA in the cytoplasm requires translational repression, multiple modular intronic elements, Edc3p, and Mex67p.

    Directory of Open Access Journals (Sweden)

    Shuyun Dong

    2010-04-01

    Full Text Available Intron-containing pre-mRNAs are normally retained and processed in the nucleus but are sometimes exported to the cytoplasm and degraded by the nonsense-mediated mRNA decay (NMD pathway as a consequence of their inclusion of intronic in-frame termination codons. When shunted to the cytoplasm by autoregulated nuclear export, the intron-containing yeast YRA1 pre-mRNA evades NMD and is targeted by a cytoplasmic decay pathway mediated by the decapping activator Edc3p. Here, we have elucidated this transcript-specific decay mechanism, showing that Edc3p-mediated YRA1 pre-mRNA degradation occurs independently of translation and is controlled through five structurally distinct but functionally interdependent modular elements in the YRA1 intron. Two of these elements target the pre-mRNA as an Edc3p substrate and the other three mediate transcript-specific translational repression. Translational repression of YRA1 pre-mRNA also requires the heterodimeric Mex67p/Mtr2p general mRNA export receptor, but not Edc3p, and serves to enhance Edc3p substrate specificity by inhibiting the susceptibility of this pre-mRNA to NMD. Collectively, our data indicate that YRA1 pre-mRNA degradation is a highly regulated process that proceeds through translational repression, substrate recognition by Edc3p, recruitment of the Dcp1p/Dcp2p decapping enzyme, and activation of decapping.

  13. Standard elements; Elements standards

    Energy Technology Data Exchange (ETDEWEB)

    Blanc, B [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    Following his own experience the author recalls the various advantages, especially in the laboratory, of having pre-fabricated vacuum-line components at his disposal. (author) [French] A la suite de sa propre experience, l'auteur veut rappeler les divers avantages que presente, tout particulierement en laboratoire, le fait d'avoir a sa disposition des elements pre-fabriques de canalisations a vide. (auteur)

  14. Multiple element isotope probes, NanoSIMS, and the functional genomics of microbial carbon cycling in soils in response to chronic climatic change

    Energy Technology Data Exchange (ETDEWEB)

    Hungate, Bruce; Pett-Ridge, Jennifer; Blazewicz, Steven; Blazewicz, Steven; Schwartz, Egbert; Dijkstra, Paul

    2018-03-24

    In this project, we developed an innovative and ground-breaking technique, quantitative stable isotope probing, a technique that uses density separation of nucleic acids as a quantitative measurement technique. This work is substantial because it advances SIP beyond the qualitative technique that has dominate the field for years. The first methods paper was published in Applied and Environmental Microbiology (Hungate et al. 2015), and this paper describes the mathematical model underlying the quantitative interpretation. A second methods paper (Schwartz et al. 2015) provides a conceptual overview of the method and its application to research problems. A third methods paper was just published (Koch et al. 2018), in which we develop the quantitative model combining sequencing and isotope data to estimate actual rates of microbial growth and death in natural populations. This work has met much enthusiasm in scientific presentations around the world. It has met with equally enthusiastic resistance in the peer-review process, though our record of publication to date argues that people are accepting the merits of the approach. The skepticism and resistance are also potentially signs that this technique is pushing the field forward, albeit with some of the discomfort that accompanies extrapolation. Part of this is a cultural element in the field – the field of microbiology is not accustomed to the assumptions of ecosystem science. Research conducted in this project has pushed the philosophical perspective that major advances can occur when we advocate a sound merger between the traditions of strong inference in microbiology with those of grounded scaling in ecosystem science.

  15. Application of synchrotron radiation to x-ray fluorescence analysis of trace elements

    International Nuclear Information System (INIS)

    Gordon, B.M.; Jones, K.W.; Hanson, A.L.

    1986-08-01

    The development of synchrotron radiation x-ray sources has provided the means to greatly extend the capabilities of x-ray fluorescence analysis for determinations of trace element concentrations. A brief description of synchrotron radiation properties provides a background for a discussion of the improved detection limits compared to existing x-ray fluorescence techniques. Calculated detection limits for x-ray microprobes with micrometer spatial resolutions are described and compared with experimental results beginning to appear from a number of laboratories. The current activities and future plans for a dedicated x-ray microprobe beam line at the National Synchrotron Light Source (NSLS) of Brookhaven National Laboratory are presented

  16. Galvanic element. Galvanisches Element

    Energy Technology Data Exchange (ETDEWEB)

    Sprengel, D.; Haelbig, H.

    1980-01-03

    The invention concerns a gas-tight sealed accumulator with positive and negative electrode plates and an auxillary electrode electroconductively bound to the latter for suppressing oxygen pressure. The auxillary electrode is an intermediate film electrode. The film catalysing oxygen reduction is hydrophilic in character and the other film is hydrophobic. A double coated foil has proved to be advantageous, the hydrophilic film being formed from polymer-bound activated carbon and the hydrophrobic film from porous polytetrafluoroethylene. A metallic network of silver or nickel is rolled into the outer side of the activated carbon film. This auxillary electrode can be used to advantage in all galvanic elements. Even primary cells fall within the scope of application for auxillary electrodes because many of these contain a highly oxidized electrodic material which tends to give off oxygen.

  17. Quantification of elemental area densities in multiple metal layers (Au/Ni/Cu) on a Cr-coated quartz glass substrate for certification of NMIJ CRM 5208-a.

    Science.gov (United States)

    Ariga, Tomoko; Zhu, Yanbei; Ito, Mika; Takatsuka, Toshiko; Terauchi, Shinya; Kurokawa, Akira; Inagaki, Kazumi

    2018-04-01

    Area densities of Au/Ni/Cu layers on a Cr-coated quartz substrate were characterized to certify a multiple-metal-layer certified reference material (NMIJ CRM5208-a) that is intended for use in the analysis of the layer area density and the thickness by an X-ray fluorescence spectrometer. The area densities of Au/Ni/Cu layers were calculated from layer mass amounts and area. The layer mass amounts were determined by using wet chemical analyses, namely inductively coupled plasma mass spectrometry (ICP-MS), isotope-dilution (ID-) ICP-MS, and inductively coupled plasma optical emission spectrometry (ICP-OES) after dissolving the layers with diluted mixture of HCl and HNO 3 (1:1, v/v). Analytical results of the layer mass amounts obtained by the methods agreed well with each another within their uncertainty ranges. The area of the layer was determined by using a high-resolution optical scanner calibrated by Japan Calibration Service System (JCSS) standard scales. The property values of area density were 1.84 ± 0.05 μg/mm 2 for Au, 8.69 ± 0.17 μg/mm 2 for Ni, and 8.80 ± 0.14 μg/mm 2 for Cu (mean ± expanded uncertainty, coverage factor k = 2). In order to assess the reliability of these values, the density of each metal layer calculated from the property values of the area density and layer thickness measured by using a scanning electron microscope were compared with available literature values and good agreement between the observed values and values obtained in previous studies.

  18. Molecular characterization of a rice mutator-phenotype derived from an incompatible cross-pollination reveals transgenerational mobilization of multiple transposable elements and extensive epigenetic instability

    Directory of Open Access Journals (Sweden)

    Xu Chunming

    2009-05-01

    Full Text Available Abstract Background Inter-specific hybridization occurs frequently in plants, which may induce genetic and epigenetic instabilities in the resultant hybrids, allopolyploids and introgressants. It remains unclear however whether pollination by alien pollens of an incompatible species may impose a "biological stress" even in the absence of genome-merger or genetic introgression, whereby genetic and/or epigenetic instability of the maternal recipient genome might be provoked. Results We report here the identification of a rice mutator-phenotype from a set of rice plants derived from a crossing experiment involving two remote and apparently incompatible species, Oryza sativa L. and Oenothera biennis L. The mutator-phenotype (named Tong211-LP showed distinct alteration in several traits, with the most striking being substantially enlarged panicles. Expectably, gel-blotting by total genomic DNA of the pollen-donor showed no evidence for introgression. Characterization of Tong211-LP (S0 and its selfed progenies (S1 ruled out contamination (via seed or pollen or polyploidy as a cause for its dramatic phenotypic changes, but revealed transgenerational mobilization of several previously characterized transposable elements (TEs, including a MITE (mPing, and three LTR retrotransposons (Osr7, Osr23 and Tos17. AFLP and MSAP fingerprinting revealed extensive, transgenerational alterations in cytosine methylation and to a less extent also genetic variation in Tong211-LP and its immediate progenies. mPing mobility was found to correlate with cytosine methylation alteration detected by MSAP but not with genetic variation detected by AFLP. Assay by q-RT-PCR of the steady-state transcript abundance of a set of genes encoding for the various putative DNA methyltransferases, 5-methylcytosine DNA glycosylases, and small interference RNA (siRNA pathway-related proteins showed that, relative to the rice parental line, heritable perturbation in expression of 12 out of

  19. Multiple cis-acting elements involved in up-regulation of a cytochrome P450 gene conferring resistance to deltamethrin in smal brown planthopper, Laodelphax striatellus (Fallén).

    Science.gov (United States)

    Pu, Jian; Sun, Haina; Wang, Jinda; Wu, Min; Wang, Kangxu; Denholm, Ian; Han, Zhaojun

    2016-11-01

    As well as arising from single point mutations in binding sites or detoxifying enzymes, it is likely that insecticide resistance mechanisms are frequently controlled by multiple genetic factors, resulting in resistance being inherited as a quantitative trait. However, empirical evidence for this is still rare. Here we analyse the causes of up-regulation of CYP6FU1, a monoxygenase implicated in resistance to deltamethrin in the rice pest Laodelphax striatellus. The 5'-flanking region of this gene was cloned and sequenced from individuals of a susceptible and a resistant strain. A luminescent reporter assay was used to evaluate different 5'-flanking regions and their fragments for promoter activity. Mutations enhancing promoter activity in various fragments were characterized, singly and in combination, by site mutation recovery. Nucleotide diversity in flanking sequences was greatly reduced in deltamethrin-resistant insects compared to susceptible ones. Phylogenetic sequence analysis found that CYP6FU1 had five different types of 5'-flanking region. All five types were present in a susceptible strain but only a single type showing the highest promoter activity was present in a resistant strain. Four cis-acting elements were identified whose influence on up-regulation was much more pronounced in combination than when present singly. Of these, two were new transcription factor (TF) binding sites produced by mutations, another one was also a new TF binding site alternated from an existing one, and the fourth was a unique transcription start site. These results demonstrate that multiple cis-acting elements are involved in up-regulating CYP6FU1 to generate a resistance phenotype. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Efeito do tipo de elemento de rosca na degradação de polipropileno durante múltiplas extrusões Effect of screw element on the polypropylene degradation during multiple extrusions

    Directory of Open Access Journals (Sweden)

    Ana Clélia Babetto

    2000-06-01

    Full Text Available A configuração da rosca de uma extrusora de dupla rosca modular pode ser projetada com vários tipos de elementos de condução e mistura, produzindo diferentes níveis de degradação no polímero fundido. Neste trabalho determinou-se o nível de degradação do polipropileno durante múltiplas extrusões em várias configurações de rosca, através de cromatografia por exclusão de tamanho e espectroscopia de infravermelho. Houve decréscimo do peso molecular e estreitamento da sua distribuição em função do número de extrusões e do aumento da agressividade da rosca, assim como, aumento da concentração de carbonilas e insaturações na cadeia polimérica. O elemento de mistura EM90 causou o maior nível de degradação e a adição de elementos de condução esquerdos ECE reduziram o nível de degradação.The screw configuration of a double screw extruder can be designed to contain kneading and conveying elements inducing different levels of degradation in the polymer melt. In this work the level of degradation in polypropylene have been measured after multiple extrusions for various screw configurations using Size Exclusion Chromatography and Infra-Red Spectroscopy. The average molecular weight and the polydispersity are reduced and the carbonyl and unsaturation indices increase as the number of extrusions and the agressiveness of the screw increase. The kneading element with 90 degrees caused the greater level of degradation and the addition of left hand elements have reduced the level of degradation.

  1. Nuclear fuel element

    International Nuclear Information System (INIS)

    Grossman, L.N.; Levin, H.A.

    1975-01-01

    A nuclear fuel element has disposed therein an alloy having the essential components of nickel, titanium and zirconium, and the alloy reacts with water, water vapor and reactive gases at reactor ambient temperatures. The alloy is disposed in the plenum of the fuel element in the form of particles in a hollow gas permeable container having a multiplicity of openings of size smallr than the size of the particles. The container is preferably held in the spring in the plenum of the fuel element. (E.C.B.)

  2. Element Distribution and Multiplicity of Heavy Fragments

    CERN Multimedia

    2002-01-01

    This experiment will measure the energy and angular distribution of heavy fragments produced in the reactions of |1|2C on several targets between |2|7Al and |2|3|8U at 86~MeV/u. The systematic investigation of a highly excited interaction region (fireball) by means of a clean N and Z identification of heavy tar fragments, may result in a better understanding of temperature concept and of the degree of equilibration of the local interaction region with respect to the total system. For this investigation a large-area position sensitive ionization chamber of 50~msr solid angle in conjunction with a time-of-flight telescope consisting of parallel-plate detectors will be used. \\\\ \\\\ In order to get information on the transverse momentum transfer and the inelasticity of the collision, the energy of the PROJECTILE-FRAGMENTS will be measured at forward angles with a plastic scintillator hodoscope. In addition to this inclusive measurement correlations between heavy fragments will be investigated by means of three pos...

  3. Cyclotrons with fast variable and/or multiple energy extraction

    Directory of Open Access Journals (Sweden)

    C. Baumgarten

    2013-10-01

    Full Text Available We discuss the possibility in principle of stripping extraction in combination with reverse bends in isochronous separate-sector cyclotrons (and/or fixed field alternating gradient accelerators. If one uses reverse bends between the sectors (instead of or in combination with drifts and places stripper foils at the sector exit edges, the stripped beam has a reduced bending radius and it should be able to leave the cyclotron within the range of the valley—even if the beam is stripped at less than full energy. We are especially interested in stripping of H_{2}^{+}, as it doubles the charge to mass ratio of the ions. However the method could be applied to other ions or ionized molecules as well. For the production of proton beams by stripping extraction of an H_{2}^{+} beam, we discuss possible designs for three types of machines: First, a low-energy cyclotron for the simultaneous production of several beams at multiple energies—for instance 15, 30, and 70 MeV—thus allowing beam delivery on several isotope production targets. In this case it can be an advantage to have a strong energy dependence of the direction of the extracted beam. Second, we consider a fast variable-energy proton machine for cancer therapy that should allow extraction (of the complete beam at all energies in the range of about 70 MeV to about 250 MeV into the same beam line. Third, we consider a high-intensity high-energy machine, where the main design goals are extraction with low losses, low activation of components, and high reliability. Especially if such a machine is considered for an accelerator driven system (ADS, this extraction mechanism has advantages: Beam trips by the failure of electrostatic elements could be avoided and the turn separation would be less critical, which allows operation at lower main cavity voltages. This would in turn reduce the number of rf trips. The price that has to be paid for these advantages is an increase in size and/or field

  4. Observation of Multiple Volume Reflection of Ultrarelativistic Protons by a Sequence of Several Bent Silicon Crystals

    CERN Document Server

    Scandale, Walter; Baricordi, S; Dalpiaz, P; Fiorini, M; Guidi, V; Mazzolari, A; Della Mea, G; Milan, R; Ambrosi, G; Zuccon, P; Bertucci, B; Bürger, W; Duranti, M; Cavoto, G; Santacesaria, R; Valente, P; Luci, C; Iacoangeli, F; Vallazza, E; Afonin, A G; Chesnokov, Yu A; Kotov, V I; Maisheev, V A; Yazynin, I A; Kovalenko, A D; Taratin, A M; Denisov, A S; Gavrikov, Y A; Ivanov, Yu M; Lapina, L P; Malyarenko, L G; Skorogobogatov, V V; Suvorov, V M; Vavilov, S A; Bolognini, D; Hasan, S; Mozzanica, A; Prest, M

    2009-01-01

    The interactions of 400 GeV protons with different sequences of bent silicon crystals have been investigated at the H8 beam line of the CERN Super Proton Synchrotron. The multiple volume reflection of the proton beam has been studied in detail on a five-crystal reflector measuring an angular beam deflection =52.96±0.14 µrad. The efficiency was found larger than 80% for an angular acceptance at the reflector entrance of 70 µrad, with a maximal efficiency value of =0.90±0.01±0.03.

  5. Transplutonium elements

    Energy Technology Data Exchange (ETDEWEB)

    Sivaramakrishnan, C. K.; Jadhav, A. V.; Reghuraman, K.; Mathew, K. A.; Nair, P. S.; Ramaniah, M. V.

    1973-07-01

    Research progress is reported on studies of the transplutonium elements including recovery and purification of americium, preparation of /sup 238/Pu, extraction studies using diethylhexyl phosphate. (DHM)

  6. Contributions to multiple element speciation in vegetable plants: Studies on the type of bonding of numerous elements, particularly zinc and cadmium; Beitraege zur Multielement-Speziation in pflanzlichen Lebensmitteln: Studien zur Bindungsform zahlreicher Elemente unter besonderer Beruecksichtigung von Zink und Cadmium

    Energy Technology Data Exchange (ETDEWEB)

    Guenther, K.

    1997-03-01

    In the first part of the study, the total contents and the solubility characteristics of Zn, Cd, Fe, Mn, Cu, Ca, Sr, K and Rb in 26 different vegetable plants, the majority of them commercially available, are reported, obtained by post-decomposition analyses. The data are given for avocados, bananas, cauliflower, chicory, Chinese cabbage, dill, ice lettuce (two specimens), endive, field salad, cucumbers, kohlrabi, lettuce, chard beet, carrots, peppers, leek, radish, red cabbage, loose leaved lettuce, celery (two specimens), spinach, topinambur, white cabbage, and parsley. Cell decomposition was done by treatment of the plant material with an electric dispersing apparatus (Ultra-Turrax) in buffer solution (liquid shearing). The homogenates were separated into supernatants (cytosoles)and pellets by means of centrifugation. Cell decomposition of the plants by crushing with quartz sand after lyophilization (solid shearing) required much more technical effort and for some elements created problems with the blind values. At least 50% on the average of the elements Zn, Cd, Rb, and K could be transferred to the solutions by the dispersing treatment with Ultra-Turrax. In many cases, the cytosole-borne detectable contents of these 5 elements were above 70%. The solubility of Zn and Cd was more strongly dependent on the plant species than that of Cu, Rb, and K. All five elements thus can be analysed by conventional methods for further enhanced speciation. Mn, Ca, and especially Fe and Sr for the most part were found to be bonded to solid cell constituents. However, the solubility characteristics of Ca and Mn and Sr in particular was very homogeneous. In some plants, the contents of Mn and Sr in the cytosoles was approx. 90%, so that comprehensive speciation of these elements is possible. (orig./AJ) [Deutsch] Im ersten Teil dieser Studie wurden die Gesamtgehalte und das Loeslichkeitsverhalten von Zn, Cd, Fe, Mn, Cu, Ca, Sr, K und Rb in 26 verschiedenen - ueberwiegend

  7. Toxic Elements

    DEFF Research Database (Denmark)

    Hajeb, Parvaneh; Shakibazadeh, Shahram; Sloth, Jens Jørgen

    2016-01-01

    Food is considered the main source of toxic element (arsenic, cadmium, lead, and mercury) exposure to humans, and they can cause major public health effects. In this chapter, we discuss the most important sources for toxic element in food and the foodstuffs which are significant contributors to h...

  8. Spatial distribution of elements in the spheroids by prostate tumor cells using synchrotron radiation x-ray fluorescence

    Energy Technology Data Exchange (ETDEWEB)

    Leitao, Roberta G.; Santos, Carlos Antonio N.; Junior, Antonio Palumbo; Souza, Pedro A. V. R.; Canellas, Catarine G. L.; Anjos, Marcelino J.; Nasciutti, Luiz E.; Lopes, Ricardo T. [Laboratorio de Instrumentacao Nuclear, PEN/COPPE, Universidade Federal do Rio de Janeiro, Ilha do Fundao, 21941-972, Rio de Janeiro, RJ (Brazil); Laboratorio de Biotecnologia - Bioengenharia - DIPRO, Instituto Nacional de Metrologia, Normalizacao e Qualidade Industrial, Xerem. 25250-020, Duque de Caxias, RJ (Brazil); Laboratorio de Interacoes Celulares, ICB-CCS, Universidade Federal do Rio de Janeiro, Ilha do Fundao, 21941- 590, Rio de Janeiro, RJ (Brazil); Laboratorio de Instrumentacao Nuclear, PEN/COPPE, Universidade Federal do Rio de Janeiro, Ilha do Fundao, 21941-972, Rio de Janeiro, RJ (Brazil); Laboratorio de Interacoes Celulares, ICB-CCS, Universidade Federal do Rio de Janeiro, Ilha do Fundao, 21941- 590, Rio de Janeiro, RJ (Brazil); Laboratorio de Instrumentacao Nuclear, PEN/COPPE, Universidade Federal do Rio de Janeiro, Ilha do Fundao, 21941-972, Rio de Janeiro, RJ (Brazil)

    2012-05-17

    The formation of three-dimensional cell microspheres such as spheroids has attracted attention as a useful culture technique. In this study, we investigated the trace elemental distribution (mapping) in spheroids derived from tissue prostate cancer (PCa). The measurements were performed in standard geometry of 45 deg. incidence, exciting with a white beam and using an optical capillary with 20 {mu}m diameter collimation in the XRF beam line at the Synchrotron Light National Laboratory (Campinas, Brazil). The results showed that most elements analyzed presented non-uniform distribution. P, S and Cl showed similar elemental distribution in all the samples analyzed. K, Ca, Fe, and Cu showed different elemental distribution for the spheroids analyzed. Zinc presented more intense distributions in the spheroid central region for all spheroids analyzed.

  9. Spatial distribution of elements in the spheroids by prostate tumor cells using synchrotron radiation X-ray fluorescence

    International Nuclear Information System (INIS)

    Leitao, Roberta G.; Canellas, Catarine G.L.; Anjos, Marcelino J.; Lopes, Ricardo T.; Santos, Carlos Antonio N.; Palumbo Junior, Antonio; Souza, Pedro A.V.R.; Nasciutti, Luiz E.

    2011-01-01

    The formation of three-dimensional cell microspheres such as spheroids has attracted attention as a useful culture technique. In this study, we investigated the trace elemental distribution (mapping) in spheroids derived from tissue prostate cancer (PCa). The measurements were performed in standard geometry of 45 deg incidence, exciting with a white beam and using an optical capillary with 20 μm diameter collimation in the XRF beam line at the Synchrotron Light National Laboratory (Campinas, Brazil). The results showed that most elements analyzed presented non-uniform distribution. P, S and Cl showed similar elemental distribution in all the samples analyzed. K, Ca, Fe, and Cu showed different elemental distribution for the spheroids analyzed. Zinc presented more intense distributions in the spheroid central region for all spheroids analyzed. (author)

  10. Spatial distribution of elements in the spheroids by prostate tumor cells using synchrotron radiation x-ray fluorescence

    International Nuclear Information System (INIS)

    Leitao, Roberta G.; Santos, Carlos Antonio N.; Junior, Antonio Palumbo; Souza, Pedro A. V. R.; Canellas, Catarine G. L.; Anjos, Marcelino J.; Nasciutti, Luiz E.; Lopes, Ricardo T.

    2012-01-01

    The formation of three-dimensional cell microspheres such as spheroids has attracted attention as a useful culture technique. In this study, we investigated the trace elemental distribution (mapping) in spheroids derived from tissue prostate cancer (PCa). The measurements were performed in standard geometry of 45 deg. incidence, exciting with a white beam and using an optical capillary with 20 μm diameter collimation in the XRF beam line at the Synchrotron Light National Laboratory (Campinas, Brazil). The results showed that most elements analyzed presented non-uniform distribution. P, S and Cl showed similar elemental distribution in all the samples analyzed. K, Ca, Fe, and Cu showed different elemental distribution for the spheroids analyzed. Zinc presented more intense distributions in the spheroid central region for all spheroids analyzed.

  11. Spatial distribution of elements in the spheroids by prostate tumor cells using synchrotron radiation X-ray fluorescence

    Energy Technology Data Exchange (ETDEWEB)

    Leitao, Roberta G.; Canellas, Catarine G.L.; Anjos, Marcelino J.; Lopes, Ricardo T. [Universidade Federal do Rio de Janeiro (PEN/COPPE/UFRJ), RJ (Brazil). Coordenacao dos Programas de Pos-Graduacao de Engenharia. Programa de Energia Nuclear; Santos, Carlos Antonio N. [Instituto Nacional de Metrologia, Normalizacao e Qualidade Industrial (INMETRO), Duque de Caxias, RJ (Brazil). Lab. de Biotecnologia - Bioengenharia; Palumbo Junior, Antonio; Souza, Pedro A.V.R.; Nasciutti, Luiz E., E-mail: nasciutt@ufrj.b [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Lab. de Interacoes Celulares

    2011-07-01

    The formation of three-dimensional cell microspheres such as spheroids has attracted attention as a useful culture technique. In this study, we investigated the trace elemental distribution (mapping) in spheroids derived from tissue prostate cancer (PCa). The measurements were performed in standard geometry of 45 deg incidence, exciting with a white beam and using an optical capillary with 20 {mu}m diameter collimation in the XRF beam line at the Synchrotron Light National Laboratory (Campinas, Brazil). The results showed that most elements analyzed presented non-uniform distribution. P, S and Cl showed similar elemental distribution in all the samples analyzed. K, Ca, Fe, and Cu showed different elemental distribution for the spheroids analyzed. Zinc presented more intense distributions in the spheroid central region for all spheroids analyzed. (author)

  12. Elements of linear space

    CERN Document Server

    Amir-Moez, A R; Sneddon, I N

    1962-01-01

    Elements of Linear Space is a detailed treatment of the elements of linear spaces, including real spaces with no more than three dimensions and complex n-dimensional spaces. The geometry of conic sections and quadric surfaces is considered, along with algebraic structures, especially vector spaces and transformations. Problems drawn from various branches of geometry are given.Comprised of 12 chapters, this volume begins with an introduction to real Euclidean space, followed by a discussion on linear transformations and matrices. The addition and multiplication of transformations and matrices a

  13. Fuel element

    International Nuclear Information System (INIS)

    Armijo, J.S.

    1976-01-01

    A fuel element for nuclear reactors is proposed which has a higher corrosion resisting quality in reactor operations. The zirconium alloy coating around the fuel element (uranium or plutonium compound) has on its inside a protection layer of metal which is metallurgically bound to the substance of the coating. As materials are namned: Alluminium, copper, niobium, stainless steel, and iron. This protective metallic layer has another inner layer, also metallurgically bound to its surface, which consists usually of a zirconium alloy. (UWI) [de

  14. Spread of ISCR1 Elements Containing blaDHA-1 and Multiple Antimicrobial Resistance Genes Leading to Increase of Flomoxef Resistance in Extended-Spectrum-β-Lactamase-Producing Klebsiella pneumoniae▿

    Science.gov (United States)

    Lee, Chen-Hsiang; Liu, Jien-Wei; Li, Chia-Chin; Chien, Chun-Chih; Tang, Ya-Fen; Su, Lin-Hui

    2011-01-01

    Increasing resistance to quinolones, aminoglycosides, and/or cephamycins in extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae exacerbates the already limited antibiotic treatment options for infections due to these microbes. In this study, the presence of resistance determinants for these antimicrobial agents was examined by PCR among ESBL-producing Klebsiella pneumoniae (ESBL-KP) isolates that caused bacteremia. Pulsed-field gel electrophoresis was used to differentiate the clonal relationship among the isolates studied. Transferability and the location of the resistance genes were analyzed by conjugation experiments, followed by DNA-DNA hybridization. Among the 94 ESBL-KP isolates studied, 20 isolates of flomoxef-resistant ESBL-KP were identified. They all carried a DHA-1 gene and were genetically diverse. CTX-M genes were found in 18 of the isolates. Among these DHA-1/CTX-M-producing K. pneumoniae isolates, ISCR1 was detected in 13 (72%) isolates, qnr genes (1 qnrA and 17 qnrB genes) were detected in 18 (100%), aac(6′)-Ib-cr was detected in 11 (61%), and 16S rRNA methylase (all armA genes) was detected in 14 (78%). Four transconjugants were available for further analysis, and qnrB4, aac(6′)-Ib-cr, armA, and blaDHA-1 were all identified on these self-transferable blaCTX-M-carrying plasmids. The genetic environments of ISCR1 associated with armA, blaDHA-1, and qnrB4 genes in the four transconjugants were identical. Replicon-type analysis revealed a FIIA plasmid among the four self-transferable plasmids, although the other three were nontypeable. The cotransfer of multiple resistance genes with the ISCR1 element-carrying plasmids has a clinical impact and warrants close monitoring and further study. PMID:21746945

  15. Spread of ISCR1 elements containing blaDHA-₁ and multiple antimicrobial resistance genes leading to increase of flomoxef resistance in extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae.

    Science.gov (United States)

    Lee, Chen-Hsiang; Liu, Jien-Wei; Li, Chia-Chin; Chien, Chun-Chih; Tang, Ya-Fen; Su, Lin-Hui

    2011-09-01

    Increasing resistance to quinolones, aminoglycosides, and/or cephamycins in extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae exacerbates the already limited antibiotic treatment options for infections due to these microbes. In this study, the presence of resistance determinants for these antimicrobial agents was examined by PCR among ESBL-producing Klebsiella pneumoniae (ESBL-KP) isolates that caused bacteremia. Pulsed-field gel electrophoresis was used to differentiate the clonal relationship among the isolates studied. Transferability and the location of the resistance genes were analyzed by conjugation experiments, followed by DNA-DNA hybridization. Among the 94 ESBL-KP isolates studied, 20 isolates of flomoxef-resistant ESBL-KP were identified. They all carried a DHA-1 gene and were genetically diverse. CTX-M genes were found in 18 of the isolates. Among these DHA-1/CTX-M-producing K. pneumoniae isolates, ISCR1 was detected in 13 (72%) isolates, qnr genes (1 qnrA and 17 qnrB genes) were detected in 18 (100%), aac(6')-Ib-cr was detected in 11 (61%), and 16S rRNA methylase (all armA genes) was detected in 14 (78%). Four transconjugants were available for further analysis, and qnrB4, aac(6')-Ib-cr, armA, and bla(DHA-1) were all identified on these self-transferable bla(CTX-M)-carrying plasmids. The genetic environments of ISCR1 associated with armA, bla(DHA-1), and qnrB4 genes in the four transconjugants were identical. Replicon-type analysis revealed a FIIA plasmid among the four self-transferable plasmids, although the other three were nontypeable. The cotransfer of multiple resistance genes with the ISCR1 element-carrying plasmids has a clinical impact and warrants close monitoring and further study.

  16. Two dimension position sensitive multi-plate PPAC

    International Nuclear Information System (INIS)

    Mao Ruishi; Guo Zhongyan; Xiao Guoqing; Zhan Wenlong; Xu Hushan; Hu Zhengguo; Wang Meng; Sun Zhiyu; Chen Zhiqiang; Chen Lixin; Li Chen; Bai Jie; Zhang Jinxia; Li Cunfan

    2003-01-01

    A two-dimensional positional sensitive multi-plate PPAC with resistance chain readout has been developed for Radioactive Ion Beam Line in Lanzhou (RIBLL). The PPAC has an active area of 100 mm x 100 mm. It consists of an anode plane, a x wire plane, a y wire plane and two cathode planes. The gaps between anode and wire planes are 3 mm. And the gaps between cathodes and wire planes also are 3 mm. When filled with iso-butane at a pressure of 6.5 mb, the 0.58 mm (FWHM) position resolution and >99.2% detection efficiencies and <±50 μm linearity of the PPAC was estimated for 3 components α source

  17. Nuclear fuel element

    International Nuclear Information System (INIS)

    Penrose, R.T.; Thompson, J.R.

    1976-01-01

    A method of protecting the cladding of a nuclear fuel element from internal attack and a nuclear fuel element for use in the core of a nuclear reactor are disclosed. The nuclear fuel element has disposed therein an additive of a barium-containing material and the barium-containing material collects reactive gases through chemical reaction or adsorption at temperatures ranging from room temperature up to fuel element plenum temperatures. The additive is located in the plenum of the fuel element and preferably in the form of particles in a hollow container having a multiplicity of gas permeable openings in one portion of the container with the openings being of a size smaller than the size of the particles. The openings permit gases and liquids entering the plenum to contact the particles. The additive is comprised of elemental barium or a barium alloy containing one or more metals in addition to barium such as aluminum, zirconium, nickel, titanium and combinations thereof. 6 claims, 3 drawing figures

  18. Transplutonium elements - a literature survey

    International Nuclear Information System (INIS)

    Sivaramakrishnan, C.K.; Jadhav, A.V.

    1974-01-01

    The report surveys reported work on the discovery of transplutonium elements and their production through various methods like bombardment of heavy elements with charged ions, successive neutron captures on heavy elements in reactors and multiple neutron captures by heavy elements during nuclear explosions. Estimated yields of transplutonium elements in special targets irradiated in reactors, and also as byproducts from spent power reactor fuels are quoted. Various chemical procedures adopted for recovery of these elements from irradiated target and also from power reactor fuel reprocessing streams are described. A brief survey of shielded facilities available at various centres for transplutonium programmes is also included. Major uses of some of these heavy elements are described. (author)

  19. PELTIER ELEMENTS

    CERN Document Server

    Tani, Laurits

    2015-01-01

    To control Peltier elements, temperature controller was used. I used TEC-1091 that was manufactured my Meerstetter Engineering. To gain control with the temperature controller, software had to be intalled on a controlling PC. There were different modes to control the Peltier: Tempererature controller to control temperature, Static current/voltage to control voltage and current and LIVE ON/OFF to auto-tune the controller respectively to the system. Also, since near the collision pipe there is much radiation, radiation-proof Peltier elements have to be used. To gain the best results, I had to find the most efficient Peltier elements and try to get their cold side to -40 degrees Celsius.

  20. Fuel element

    International Nuclear Information System (INIS)

    Kennedy, S.T.

    1982-01-01

    A nuclear reactor fuel element wherein a stack of nuclear fuel is prevented from displacement within its sheath by a retainer comprising a tube member which is radially expanded into frictional contact with the sheath by means of a captive ball within a tapered bore. (author)

  1. Transactinide elements

    International Nuclear Information System (INIS)

    Hemingway, J.D.

    1975-01-01

    The review is covered in sections, entitled: predicted nuclear properties - including closed shells, decay characteristics; predicted chemical properties - including electronic structure and calculated properties, X-radiation, extrapolated chemical properties, separation chemistry; methods of synthesis; the natural occurrence of superheavy elements. (U.K.)

  2. Multiple Perspectives / Multiple Readings

    Directory of Open Access Journals (Sweden)

    Simon Biggs

    2005-01-01

    Full Text Available People experience things from their own physical point of view. What they see is usually a function of where they are and what physical attitude they adopt relative to the subject. With augmented vision (periscopes, mirrors, remote cameras, etc we are able to see things from places where we are not present. With time-shifting technologies, such as the video recorder, we can also see things from the past; a time and a place we may never have visited.In recent artistic work I have been exploring the implications of digital technology, interactivity and internet connectivity that allow people to not so much space/time-shift their visual experience of things but rather see what happens when everybody is simultaneously able to see what everybody else can see. This is extrapolated through the remote networking of sites that are actual installation spaces; where the physical movements of viewers in the space generate multiple perspectives, linked to other similar sites at remote locations or to other viewers entering the shared data-space through a web based version of the work.This text explores the processes involved in such a practice and reflects on related questions regarding the non-singularity of being and the sense of self as linked to time and place.

  3. New elements

    International Nuclear Information System (INIS)

    Flerov, G.

    1976-01-01

    The history is briefly described of the investigation of superheavy elements at the Joint Institute for Nuclear Research at Dubna. The significance of the investigation is assessed from the point of view of the nuclear structure study and major problems encountered in experimental efforts are indicated. Current experimental methods aiming at the discovery or the production of superheavy nuclei with Z approximately 114 are listed. (I.W.)

  4. Radiographic element

    International Nuclear Information System (INIS)

    Abbott, T.I.; Jones, C.G.

    1984-01-01

    Radiographic elements are disclosed comprised of first and second silver halide emulsion layers separated by an interposed support capable of transmitting radiation to which the second image portion is responsive. At least the first imaging portion contains a silver halide emulsion in which thin tubular silver halide grains of intermediate aspect ratios (from 5:1 to 8:1) are present. Spectral sensitizing dye is adsorbed to the surface of the tubular grains. Increased photographic speeds can be realized at comparable levels of crossover. (author)

  5. Superheavy elements

    CERN Document Server

    Hofmann, S

    1999-01-01

    The outstanding aim of experimental investigations of heavy nuclei is the exploration of spherical 'SuperHeavy Elements' (SHEs). On the basis of the nuclear shell model, the next double magic shell-closure beyond sup 2 sup 0 sup 8 Pb is predicted at proton numbers between Z=114 and 126 and at neutron number N=184. All experimental efforts aiming at identifying SHEs (Z>=114) were negative so far. A highly sensitive search experiment was performed in November-December 1995 at SHIP. The isotope sup 2 sup 9 sup 0 116 produced by 'radiative capture' was searched for in the course of a 33 days irradiation of a sup 2 sup 0 sup 8 Pb target with sup 8 sup 2 Se projectiles, however, only cross-section limits were measured. Positive results were obtained in experiments searching for elements from 110 to 112 using cold fusion and the 1n evaporation channel. The produced isotopes were unambiguously identified by means of alpha-alpha correlations. Not fission, but alpha emission is the dominant decay mode. The measurement ...

  6. Multiple sclerosis

    Science.gov (United States)

    ... indwelling catheter Osteoporosis or thinning of the bones Pressure sores Side effects of medicines used to treat the ... Daily bowel care program Multiple sclerosis - discharge Preventing pressure ulcers Swallowing problems Images Multiple sclerosis MRI of the ...

  7. Nuclear fuel element

    International Nuclear Information System (INIS)

    1974-01-01

    A nuclear fuel element for use in the core of a nuclear reactor is disclosed. A heat conducting fission product retaining metal liner of a refractory metal is incorporated in the fuel element between the cladding and the nuclear fuel to inhibit mechanical interaction between the nuclear fuel and the cladding, to isolate fission products and nuclear fuel impurities from contacting the cladding, and to improve the axial thermal peaking gradient along the length of the fuel rod. The metal liner can be in the form of a tube or hollow cylindrical column, a foil of single or multiple layers in the shape of a hollow cylindrical column, or a coating on the internal surface of the cladding. Preferred refractory metal materials are molybdenum, tungsten, rhenium, niobium and alloys of the foregoing metals

  8. Nuclear fuel element

    International Nuclear Information System (INIS)

    Thompson, J.R.; Rowland, T.C.

    1976-01-01

    A nuclear fuel element for use in the core of a nuclear reactor is disclosed. A heat conducting, fission product retaining metal liner of a refractory metal is incorporated in the fuel element between the cladding and the nuclear fuel to inhibit mechanical interaction between the nuclear fuel and the cladding, to isolate fission products and nuclear fuel impurities from contacting the cladding and to improve the axial thermal peaking gradient along the length of the fuel rod. The metal liner can be in the form of a tube or hollow cylindrical column, a foil of single or multiple layers in the shape of a hollow cylindrical column, or a coating on the internal surface of the cladding. Preferred refractory metal materials are molybdenum, tungsten, rhenium, niobium and alloys of the foregoing metals

  9. Elemental mapping by synchrotron radiation X-Ray microfluorescence in cellular spheroid of prostate tumor cells

    Energy Technology Data Exchange (ETDEWEB)

    Leitao, R.G.; Anjos, M.J.; Lopes, R.T., E-mail: roberta@lin.ufrj.br [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Lab. de Instrumentacao Nuclear; Santos, C.A.N. [Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO), Duque de Caxias, RJ (Brazil). Lab. de Biotecnologia; Palumbo Junior, A.; Souza, P.A.V.R.; Nasciutti, L.E. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Instituto de Ciencias Biomedicas; Pereira, G.R. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Lab. de Ensaios Nao Destrutivos, Corrosao e Soldagem

    2013-08-15

    Prostate cancer is the sixth most common type of cancer and the third most common in males in Western industrialized countries. Cellular spheroid serves as excellent physiologic tumor models as they mimic avascular tumors and micrometastases. Trace elements play a significant role in biological processes. They are capable of affecting human health by competing with essential elements for available binding sites and by the activation or inhibition of reactions between metabolic enzymes. It is well known that zinc levels in the peripheral zone of dorsal and lateral lobes of the prostate are almost 10 times higher than in other soft tissues. Prostate tumor cells were isolated of the prostate tissue samples that were collected from patients submitted to surgery. The measurements were performed in XRF beam line at the Synchrotron Light National Laboratory (LNLS) in Campinas, Brazil. The results showed that all elements were heterogeneously distributed in different areas of the spheroids analyzed. P, S and Cl showed similar elemental distribution in all the samples analyzed while K, Ca, Fe, and Cu showed different elemental distribution. In all spheroids analyzed, Zn presented more intense distributions in the central region of the spheroid. The relationship between the function of Zn in the secretory epithelial cells and the carcinogenic process suggests that more studies on elemental mapping in spheroids are necessary. (author)

  10. Elemental mapping by synchrotron radiation X-Ray microfluorescence in cellular spheroid of prostate tumor cells

    International Nuclear Information System (INIS)

    Leitao, R.G.; Anjos, M.J.; Lopes, R.T.; Santos, C.A.N.; Palumbo Junior, A.; Souza, P.A.V.R.; Nasciutti, L.E.; Pereira, G.R.

    2013-01-01

    Prostate cancer is the sixth most common type of cancer and the third most common in males in Western industrialized countries. Cellular spheroid serves as excellent physiologic tumor models as they mimic avascular tumors and micrometastases. Trace elements play a significant role in biological processes. They are capable of affecting human health by competing with essential elements for available binding sites and by the activation or inhibition of reactions between metabolic enzymes. It is well known that zinc levels in the peripheral zone of dorsal and lateral lobes of the prostate are almost 10 times higher than in other soft tissues. Prostate tumor cells were isolated of the prostate tissue samples that were collected from patients submitted to surgery. The measurements were performed in XRF beam line at the Synchrotron Light National Laboratory (LNLS) in Campinas, Brazil. The results showed that all elements were heterogeneously distributed in different areas of the spheroids analyzed. P, S and Cl showed similar elemental distribution in all the samples analyzed while K, Ca, Fe, and Cu showed different elemental distribution. In all spheroids analyzed, Zn presented more intense distributions in the central region of the spheroid. The relationship between the function of Zn in the secretory epithelial cells and the carcinogenic process suggests that more studies on elemental mapping in spheroids are necessary. (author)

  11. Design and finite element simulation of vacuum systems for insertion devices in Indus-2 storage ring

    International Nuclear Information System (INIS)

    Yadav, D.P.; Bais, Vijay; Sridhar, R.; Dhimole, Vivek K.; Nitesh, Suthar; Rawal, B.R.; Chogaonkar, Swati

    2015-01-01

    Indus-2 is a 2.5 GeV, 300 mA, Synchrotron Radiation Source (SRS) located at Raja Ramanna Centre for Advanced Technology, Indore. As part of insertion device (ID) development programme two new devices namely, APPLE-2 (Advanced Planar Polarized Light Emitter) type Undulator (also known as U-3 Undulator) and 5 Tesla superconducting wavelength shifter (SWLS) are being developed. APPLE-2 will generate variably polarized synchrotron radiation (SR) required for carrying out magnetic circular dichroism (MCD) and magnetic linear dichroism (MLD) experiments and SWLS will generate synchrotron radiation (SR) with critical photon energy of about 20.8 keV for Energy Dispersive XRD beam line. This paper describes design details and finite element analysis results of various simulations carried out for the vacuum systems of these IDs

  12. Fuel element

    International Nuclear Information System (INIS)

    Hirose, Yasuo.

    1982-01-01

    Purpose: To increase the plenum space in a fuel element used for a liquid metal cooled reactor. Constitution: A fuel pellet is secured at one end with an end plug and at the other with a coil spring in a tubular container. A mechanism for fixing the coil spring composed of a tubular unit is mounted by friction with the inner surface of the tubular container. Accordingly, the recoiling force of the coil spring can be retained by fixing mechanism with a small volume, and since a large amount of plenum space can be obtained, the internal pressure rise in the cladding tube can be suppressed even if large quantities of fission products are discharged. (Kamimura, M.)

  13. Multiple Coulomb scattering of high-energy heavy charged particle beams used in biology and medicine

    International Nuclear Information System (INIS)

    Wong, M.; Schimmerling, W.; Ludewigt, B.; Phillips, M.; Curtis, S.; Tobias, C.A.

    1987-01-01

    The authors measured lateral displacement and angular distributions of high-energy heavy charged particles emerging from a target at the Lawrence Berkeley Laboratory BEVALAC with beams used in radiobiology experiments. Multiple Coulomb scattering occurring in the target material generally spreads the beam laterally and increases its divergence. The apparatus consists of four sets of position-sensitive semiconductor detectors located along the beam line. Each providing two position signals and one energy signal. The difference between the two position signals is used to determine the particle position in one dimension. The two position signals are constrained to add up to the energy deposition signal in order to reject multiple-particle traversals. The vector directions for the incident and emerging particles are reconstructed in three dimensions from their measured coordinated positions. Lateral and angular distributions are reported for beams of high-energy neon, iron and uranium ions incident on targets of aluminum, cooper, lead and water

  14. MULTIPLE OBJECTS

    Directory of Open Access Journals (Sweden)

    A. A. Bosov

    2015-04-01

    Full Text Available Purpose. The development of complicated techniques of production and management processes, information systems, computer science, applied objects of systems theory and others requires improvement of mathematical methods, new approaches for researches of application systems. And the variety and diversity of subject systems makes necessary the development of a model that generalizes the classical sets and their development – sets of sets. Multiple objects unlike sets are constructed by multiple structures and represented by the structure and content. The aim of the work is the analysis of multiple structures, generating multiple objects, the further development of operations on these objects in application systems. Methodology. To achieve the objectives of the researches, the structure of multiple objects represents as constructive trio, consisting of media, signatures and axiomatic. Multiple object is determined by the structure and content, as well as represented by hybrid superposition, composed of sets, multi-sets, ordered sets (lists and heterogeneous sets (sequences, corteges. Findings. In this paper we study the properties and characteristics of the components of hybrid multiple objects of complex systems, proposed assessments of their complexity, shown the rules of internal and external operations on objects of implementation. We introduce the relation of arbitrary order over multiple objects, we define the description of functions and display on objects of multiple structures. Originality.In this paper we consider the development of multiple structures, generating multiple objects.Practical value. The transition from the abstract to the subject of multiple structures requires the transformation of the system and multiple objects. Transformation involves three successive stages: specification (binding to the domain, interpretation (multiple sites and particularization (goals. The proposed describe systems approach based on hybrid sets

  15. Magnetic elements in otoliths of lagena and their function

    International Nuclear Information System (INIS)

    Harada, Yasuo

    2002-01-01

    The mystery of pigeons' homing abilities has been the subject of much interest, and it is widely believed that information from the earth's magnetic field may be involved. However, no specific magnetic sensory organ has yet been identified. The recent finding of magnetic materials in the lagenal otolith of fishes and birds raises the possibility that these structures might be key elements in the elusive magnetic sensor system. For the elemental analysis inside materials, x-ray fluorescence method (Synchrotron radiation) is one of the most powerful techniques. BL4A beam line of Photo factory of KEK at Tsukuba was used for analysis of the otolith. Comparing the compositions of the three different kinds of otolith among several species of sea fishes and birds, we found that the saccular and utricular otolith rarely contain detectable levels of Fe (iron), but that Fe is present in significant quantities in the lagenal otolith of the birds. The lagenal otolith is tiny crystal that contains magnetic elements and is sensitively displaced by imposed magnetic fields, providing the animal with geomagnetic sensory input, from which the brain would infer navigational information. Behavioral experiments of the homing abilities of the pigeons involving sectioning the lagenal nerves and the magnetic interfere to their lagena were done using 30 controlled birds and 21 treated birds from the same loft of the racing pigeons. The result of homing test of the control and treated pigeons clearly indicates the magnetic influence and lagenal function to pigeon's navigation ability, and the treated pigeons were either lost or significantly delayed, while the controls returned within 30 minutes after the release. Thus the birds' lagena is unique organ, and it may be concluded that the lagena is a key element to magnetic sensory system for birds. (author)

  16. Multiple sclerosis

    International Nuclear Information System (INIS)

    Grunwald, I.Q.; Kuehn, A.L.; Backens, M.; Papanagiotou, P.; Shariat, K.; Kostopoulos, P.

    2008-01-01

    Multiple sclerosis is the most common chronic inflammatory disease of myelin with interspersed lesions in the white matter of the central nervous system. Magnetic resonance imaging (MRI) plays a key role in the diagnosis and monitoring of white matter diseases. This article focuses on key findings in multiple sclerosis as detected by MRI. (orig.) [de

  17. Project for a beam line consecrated to soft condensed matter, common heterogeneous materials and non-crystalline materials on soleil; Proposition pour une ligne dediee a la matiere molle, aux materiaux de grande diffusion et aux materiaux non-cristallises sur soleil

    Energy Technology Data Exchange (ETDEWEB)

    Ne, F.; Zemb, T. [CEA Saclay, 91 - Gif-sur-Yvette (France). Dept. de Recherche sur l`Etat Condense, les Atomes et les Molecules; Diat, O. [ESRF, 38 - Grenoble (France)

    1998-12-31

    This project is a part of the `SOLEIL` synchrotron project. The camera proposed is optimized for small angle x-ray scattering in the domain of soft condensed matter, common heterogeneous materials such as wood, cements, glass, and more generally non-crystalline materials. The beam line is designed to allow a quick succession of different users without time consuming adjustments. Therefore, optical settings are minimized, taking into account the pluri-disciplinary nature of the analysis possibilities. To this end, the technical requirements are as follows. First and essentially, the wave-length has to be fixed and set around 12 keV. Focusing mirrors, optics to sample and sample to detector distances, and the size of the detector allow for a wide range of wave vector to be used. Rejection rate will be lower, and angular dynamical range will be larger than any of the current synchrotron lines. We want this line to be, and to stay, complementary to more specific systems, such as reflectivity experiments or grazing angle scattering experiments. However, we are thinking of an adaptation to ultra small angle scattering mode, based on the Bonse and Hart camera. Such equipment, actually a kind of `Instamatic` of the reciprocal space, will fulfill to the need of chemical engineers, biophysicists or material scientists interested in hard as well as soft condensed matter. It will allow a large amount of experiments per time unit. (author)

  18. Multiple homicides.

    Science.gov (United States)

    Copeland, A R

    1989-09-01

    A study of multiple homicides or multiple deaths involving a solitary incident of violence by another individual was performed on the case files of the Office of the Medical Examiner of Metropolitan Dade County in Miami, Florida, during 1983-1987. A total of 107 multiple homicides were studied: 88 double, 17 triple, one quadruple, and one quintuple. The 236 victims were analyzed regarding age, race, sex, cause of death, toxicologic data, perpetrator, locale of the incident, and reason for the incident. This article compares this type of slaying with other types of homicide including those perpetrated by serial killers. Suggestions for future research in this field are offered.

  19. Multiple Sclerosis

    Science.gov (United States)

    Multiple sclerosis (MS) is a nervous system disease that affects your brain and spinal cord. It damages the myelin sheath, the material that surrounds and protects your nerve cells. This damage slows down ...

  20. Multiple myeloma.

    LENUS (Irish Health Repository)

    Collins, Conor D

    2012-02-01

    Advances in the imaging and treatment of multiple myeloma have occurred over the past decade. This article summarises the current status and highlights how an understanding of both is necessary for optimum management.

  1. Multiple mononeuropathy

    Science.gov (United States)

    ... with multiple mononeuropathy are prone to new nerve injuries at pressure points such as the knees and elbows. They should avoid putting pressure on these areas, for example, by not leaning on the elbows, crossing the knees, ...

  2. Synchrotron Radiation Beam Line of Piezoelectric Monochromator Control

    International Nuclear Information System (INIS)

    Ye Shengan; LIU Ping; Zheng Lifang

    2009-01-01

    It describes a Piezo Amplifier and Servo-controller module applied in the LN2-cooled Monochromator control system. The application of RS232 communication based on EPICS software environment and its software are implemented. (authors)

  3. Doppler-shifted neutral beam line shape and beam transmission

    International Nuclear Information System (INIS)

    Kamperschroer, J.H.; Grisham, L.R.; Kokatnur, N.; Lagin, L.J.; Newman, R.A.; O'Connor, T.E.; Stevenson, T.N.; von Halle, A.

    1994-04-01

    Analysis of Doppler-shifted Balmer-α line emission from the TFTR neutral beam injection systems has revealed that the line shape is well approximated by the sum of two Gaussians, or, alternatively, by a Lorentzian. For the sum of two Gaussians, the broad portion of the distribution contains 40% of the beam power and has a divergence five times that of the narrow part. Assuming a narrow 1/e- divergence of 1.3 degrees (based on fits to the beam shape on the calorimeter), the broad part has a divergence of 6.9 degrees. The entire line shape is also well approximated by a Lorentzian with a half-maximum divergence of 0.9 degrees. Up to now, fusion neutral beam modelers have assumed a single Gaussian velocity distribution, at the extraction plane, in each direction perpendicular to beam propagation. This predicts a beam transmission efficiency from the ion source to the calorimeter of 97%. Waterflow calorimetry data, however, yield a transmission efficiency of ∼75%, a value in rough agreement with predictions of the Gaussian or Lorentzian models presented here. The broad wing of the two Gaussian distribution also accurately predicts the loss in the neutralizer. An average angle of incidence for beam loss at the exit of the neutralizer is 2.2 degrees, rather than the 4.95 degrees subtended by the center of the ion source. This average angle of incidence, which is used in computing power densities on collimators, is shown to be a function of beam divergence

  4. Engineering Design of Electrostatic Quadrupole for ISOL Beam Lines

    International Nuclear Information System (INIS)

    Kim, H. S.; Kwon, H. J.; Cho, Y. S.

    2014-01-01

    In the ISOL system, the RI beam should be transported from the target ion source to post accelerator through various analyzing and charge-breeding systems such as PS (pre-seperator), HRMS (High Resolution Mass Seperator), RF cooler and A/q separator. A reference particle for the beam dynamics calculation is 132 Sn 1+ . After charge breeder system, the charge state is boosted from +1 to +19 with ECR charge breeder and to +33 with EBIS charge breeder. Because the beam energy is as low as 50 keV, the electrostatic optics was adopted rather than the magnetic optics. The electrostatic quadrupole triplets were used for the beam focusing and the electrostatic bender is used for 90-degree bending. In this paper, the design procedure and engineering design of the electrostatic quadrupole are presented

  5. SUNY beam line X3, National Synchrotron Light Source

    International Nuclear Information System (INIS)

    1991-01-01

    This report discusses: beamline change and upgrades at NSLS; crystallography; surface structure; small angle scattering; EXAFS, glazing angle and fluorescence studies; and high temperature superconductors. (LSP)

  6. The Brookhaven ATF low-emittance beam line

    International Nuclear Information System (INIS)

    Wang, X.J.; Kirk, H.G.

    1991-01-01

    One component of the experimental program at the Brookhaven Accelerator Test Facility (ATF) consists of a class of experiments which will study the acceleration of electrons through micron-size structures which are exposed in coincidence to a 100 GW CO 2 laser beam. These experiments require the development and control of an electron beam with geometric emittances on the order of 10 -10 m-rad and intensities on the order of 10 6 electrons. In this paper, the authors describe the strategies for producing such beams and the effects of higher-order aberrations. Particle tracking results are presented for the final-focus system

  7. SUNY beam line X3, National Synchrotron Light Source

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    This report discusses: beamline change and upgrades at NSLS; crystallography; surface structure; small angle scattering; EXAFS, glazing angle and fluorescence studies; and high temperature superconductors. (LSP).

  8. The Brookhaven ATF low-emittance beam line

    International Nuclear Information System (INIS)

    Wang, X.J.

    1991-01-01

    One component of the experimental program at the Brookhaven Accelerator Test Facility (ATF) consists of a class of experiments which will study the acceleration of electrons through micron-size structures which are exposed in coincidence to a 100 GW CO 2 laser beam. These experiments require the development and control of an electron beam with geometric emittances on the order of 10 -10 m-rad and intensities on the order of 10 6 electrons. In this paper, we describe the strategies for producing such beams and the effects of high-order aberrations. Particle tracking results are presented for the final-focus system. 9 refs., 6 figs., 2 tabs

  9. Beam Line and Associated Work: Operational Phase 1985-1987

    Science.gov (United States)

    1988-08-26

    ENEA FEL experiment. F. Cicci, E. Fiorentino. A. Ranieri, E. Sabie. Centro Ricerche Energia Frascati (Italy?. ....................... 169 582.25...C) knife-edge pinhole bracket (cf. Fig. 14); (D) beam stop; (E) calorimeter with an attached Si solar cell detector; (F) paddle with tilted platforms...used for T real-time signal pickup behind the slit was a standard Si solar cell, epoxied to the calorimeter case (detail . in Fig. 5). The experimental

  10. Optimum steering of photon beam lines in SPEAR

    International Nuclear Information System (INIS)

    Corbett, W.J.; Fong, B.; Lee, M.; Ziemann, V.

    1993-04-01

    A common operational requirement for many synchrotron light sources is to maintain steered photon beamlines with minimum corrector strength values. To solve this problem for SPEAR, we employed the Singular Value Decomposition (SVD) matrix-inversion technique to minimize corrector strengths while constraining the photon beamlines to remain on target. The result was a reduction in corrector strengths, yielding increased overhead for the photon-beam position feedback systems

  11. Interleaving of beam lines inside the PS tunnel

    CERN Multimedia

    1983-01-01

    View against the direction of the proton beams. The PS ring (section 26) is on the left. The injection tunnel for LEAR leaving from here has increased the trafic in this already busy area where the two Linacs and the transfer tunnel leading to the SPS, ISR and AA join the PS ring (cf. photo 7802260, 7802261, Annual Report 1981, p. 89, fig. 12).

  12. Muon energy estimate through multiple scattering with the MACRO detector

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosio, M.; Antolini, R.; Auriemma, G.; Bakari, D.; Baldini, A.; Barbarino, G.C.; Barish, B.C.; Battistoni, G.; Becherini, Y.; Bellotti, R.; Bemporad, C.; Bernardini, P.; Bilokon, H.; Bloise, C.; Bower, C.; Brigida, M.; Bussino, S.; Cafagna, F.; Calicchio, M.; Campana, D.; Candela, A.; Carboni, M.; Caruso, R.; Cassese, F.; Cecchini, S.; Cei, F.; Chiarella, V.; Choudhary, B.C.; Coutu, S.; Cozzi, M.; De Cataldo, G.; De Deo, M.; Dekhissi, H.; De Marzo, C.; De Mitri, I.; Derkaoui, J.; De Vincenzi, M.; Di Credico, A.; Dincecco, M.; Erriquez, O.; Favuzzi, C.; Forti, C.; Fusco, P.; Giacomelli, G.; Giannini, G.; Giglietto, N.; Giorgini, M.; Grassi, M.; Gray, L.; Grillo, A.; Guarino, F.; Gustavino, C.; Habig, A.; Hanson, K.; Heinz, R.; Iarocci, E.; Katsavounidis, E.; Katsavounidis, I.; Kearns, E.; Kim, H.; Kyriazopoulou, S.; Lamanna, E.; Lane, C.; Levin, D.S.; Lindozzi, M.; Lipari, P.; Longley, N.P.; Longo, M.J.; Loparco, F.; Maaroufi, F.; Mancarella, G.; Mandrioli, G.; Margiotta, A.; Marini, A.; Martello, D.; Marzari-Chiesa, A.; Mazziotta, M.N.; Michael, D.G.; Monacelli, P.; Montaruli, T.; Monteno, M.; Mufson, S.; Musser, J.; Nicolo, D.; Nolty, R.; Orth, C.; Osteria, G.; Palamara, O.; Patera, V.; Patrizii, L.; Pazzi, R.; Peck, C.W.; Perrone, L.; Petrera, S.; Pistilli, P.; Popa, V.; Raino, A.; Reynoldson, J.; Ronga, F.; Rrhioua, A.; Satriano, C.; Scapparone, E. E-mail: eugenio.scapparone@bo.infn.it; Scholberg, K.; Sciubba, A.; Serra, P.; Sioli, M. E-mail: maximiliano.sioli@bo.infn.it; Sirri, G.; Sitta, M.; Spinelli, P.; Spinetti, M.; Spurio, M.; Steinberg, R.; Stone, J.L.; Sulak, L.R.; Surdo, A.; Tarle, G.; Tatananni, E.; Togo, V.; Vakili, M.; Walter, C.W.; Webb, R

    2002-10-21

    Muon energy measurement represents an important issue for any experiment addressing neutrino-induced up-going muon studies. Since the neutrino oscillation probability depends on the neutrino energy, a measurement of the muon energy adds an important piece of information concerning the neutrino system. We show in this paper how the MACRO limited streamer tube system can be operated in drift mode by using the TDCs included in the QTPs, an electronics designed for magnetic monopole search. An improvement of the space resolution is obtained, through an analysis of the multiple scattering of muon tracks as they pass through our detector. This information can be used further to obtain an estimate of the energy of muons crossing the detector. Here we present the results of two dedicated tests, performed at CERN PS-T9 and SPS-X7 beam lines, to provide a full check of the electronics and to exploit the feasibility of such a multiple scattering analysis. We show that by using a neural network approach, we are able to reconstruct the muon energy for E{sub {mu}}<40 GeV. The test beam data provide an absolute energy calibration, which allows us to apply this method to MACRO data.

  13. Muon energy estimate through multiple scattering with the MACRO detector

    CERN Document Server

    Ambrosio, M; Auriemma, G; Bakari, D; Baldini, A; Barbarino, G C; Barish, B C; Battistoni, G; Becherini, Y; Bellotti, R; Bemporad, C; Bernardini, P; Bilokon, H; Bloise, C; Bower, C; Brigida, M; Bussino, S; Cafagna, F; Calicchio, M; Campana, D; Candela, A; Carboni, M; Caruso, R; Cassese, F; Cecchini, S; Cei, F; Chiarella, V; Choudhary, B C; Coutu, S; Cozzi, M; De Cataldo, G; De Deo, M; Dekhissi, H; De Marzo, C; De Mitri, I; Derkaoui, J; De Vincenzi, M; Di Credico, A; Dincecco, M; Erriquez, O; Favuzzi, C; Forti, C; Fusco, P; Giacomelli, G; Giannini, G; Giglietto, N; Giorgini, M; Grassi, M; Gray, L; Grillo, A; Guarino, F; Gustavino, C; Habig, A; Hanson, K; Heinz, R; Iarocci, E; Katsavounidis, E; Katsavounidis, I; Kearns, E; Kim, H; Kyriazopoulou, S; Lamanna, E; Lane, C; Levin, D S; Lindozzi, M; Lipari, P; Longley, N P; Longo, M J; Loparco, F; Maaroufi, F; Mancarella, G; Mandrioli, G; Margiotta, A; Marini, A; Martello, D; Marzari-Chiesa, A; Mazziotta, M N; Michael, D G; Monacelli, P; Montaruli, T; Monteno, M; Mufson, S; Musser, J; Nicolò, D; Nolty, R; Orth, C; Osteria, G; Palamara, O; Patera, V; Patrizii, L; Pazzi, R; Peck, C W; Perrone, L; Petrera, S; Pistilli, P; Popa, V; Rainó, A; Reynoldson, J; Ronga, F; Rrhioua, A; Satriano, C; Scapparone, E; Scholberg, K; Sciubba, A; Serra, P; Sioli, M; Sirri, G; Sitta, M; Spinelli, P; Spinetti, M; Spurio, M; Steinberg, R; Stone, J L; Sulak, L R; Surdo, A; Tarle, G; Tatananni, E; Togo, V; Vakili, M; Walter, C W; Webb, R

    2002-01-01

    Muon energy measurement represents an important issue for any experiment addressing neutrino-induced up-going muon studies. Since the neutrino oscillation probability depends on the neutrino energy, a measurement of the muon energy adds an important piece of information concerning the neutrino system. We show in this paper how the MACRO limited streamer tube system can be operated in drift mode by using the TDCs included in the QTPs, an electronics designed for magnetic monopole search. An improvement of the space resolution is obtained, through an analysis of the multiple scattering of muon tracks as they pass through our detector. This information can be used further to obtain an estimate of the energy of muons crossing the detector. Here we present the results of two dedicated tests, performed at CERN PS-T9 and SPS-X7 beam lines, to provide a full check of the electronics and to exploit the feasibility of such a multiple scattering analysis. We show that by using a neural network approach, we are able to r...

  14. [Multiple meningiomas].

    Science.gov (United States)

    Terrier, L-M; François, P

    2016-06-01

    Multiple meningiomas (MMs) or meningiomatosis are defined by the presence of at least 2 lesions that appear simultaneously or not, at different intracranial locations, without the association of neurofibromatosis. They present 1-9 % of meningiomas with a female predominance. The occurrence of multiple meningiomas is not clear. There are 2 main hypotheses for their development, one that supports the independent evolution of these tumors and the other, completely opposite, that suggests the propagation of tumor cells of a unique clone transformation, through cerebrospinal fluid. NF2 gene mutation is an important intrinsic risk factor in the etiology of multiple meningiomas and some exogenous risk factors have been suspected but only ionizing radiation exposure has been proven. These tumors can grow anywhere in the skull but they are more frequently observed in supratentorial locations. Their histologic types are similar to unique meningiomas of psammomatous, fibroblastic, meningothelial or transitional type and in most cases are benign tumors. The prognosis of these tumors is eventually good and does not differ from the unique tumors except for the cases of radiation-induced multiple meningiomas, in the context of NF2 or when diagnosed in children where the outcome is less favorable. Each meningioma lesion should be dealt with individually and their multiple character should not justify their resection at all costs. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  15. Few atom chemistry of the trans actinide element rutherfordium (Rf)

    International Nuclear Information System (INIS)

    Nagame, Y.

    2002-01-01

    Studies of chemical properties of the trans actinide elements - starting with element 104 (Rf) - offer the unique opportunity to obtain information about trends in the Periodic Table at the limits of nuclear stability and to assess the magnitude of the influence of relativistic effects on chemical properties. To explore experimentally the influence of relativistic effects of electron shell structure, we study the chemical properties of the trans actinide elements. So far, we have developed some experimental apparatuses for the study of chemical properties of the trans actinide elements: a beam-line safety system for the usage of the gas-jet coupled radioactive 248 Cm target chamber for the production of trans actinides, a rotating wheel catcher apparatus for the measurement of α particles and spontaneous fission decay of trans actinides and an automated rapid chemical separation apparatus based on high performance liquid chromatography. The trans actinide nuclide, the element 104, 261 Rf (t 1/2 = 78 s) has been successfully produced via the reactions of 248 Cm( 18 O,5n) at the JAERI (Japan Atomic Energy Research Institute) tandem accelerator. The evaluated production cross section was about 10 nb, indicating that the production rate was approximately 2 atoms per min. Because of the short half-life and the low production rate of Rf, each atom produced decays before a new atom is synthesized. It means that any chemistry to be performed must be done on an 'atom-at-a-time' basis. Therefore rapid, very efficient and selective chemical procedures are indispensable to isolate the desired trans actinide 261 Rf. To perform fast and repetitive ion-exchange separation of Rf, we have developed the apparatus AIDA (Automated Ion exchange separation system coupled with the Detection apparatus for Alpha spectroscopy). Recently, ion-exchange behavior of Rf in acidic solutions has been studied with AIDA, and the results indicate that anion-exchange behavior of Rf is quite similar

  16. K-shell x-ray production cross sections of selected elements Al to Ni for 4. 0 to 38. 0 MeV /sup 10/B ions. [Cross sections, 4. 0 to 38 MeV, binding energy, electron capture decay, PWBA, energy shifts, multiple ionization

    Energy Technology Data Exchange (ETDEWEB)

    Monigold, G.; McDaniel, F.D.; Duggan, J.L.; Mehta, R.; Rice, R.; Miller, P.D.

    1976-01-01

    K-Shell x-ray production cross sections for the target elements Sc, Ti, V, Mn, Fe, Co, and Ni were measured for incident /sup 10/B ions over the energy range 4.0 to 38.0 MeV. The cross section data were compared to the theoretical predictions of the binary encounter approximation (BEA); the plane wave born approximation (PWBA); and the PWBA modified to include corrections for increased binding energy (B), Coulomb deflection of the incident ion (C), orbital perturbation due to polarization (P), and relativistic effects (R). In addition, fluorescence yield variations (W/sub K/) and contributions to the cross sections from electron capture (EC) were included. It was found that the predictions of the fully modified PWBA with contributions from electron capture and fluorescence yield variations included provided the best fit to the experimental data over the entire energy range for each target element. The K..beta../K..cap alpha.. x-ray intensity ratios were compared to theoretical values that assume single hole ionization, and the x-ray energy shifts presented as a function of the energy of the incident ion. These two measurements provided confirmation of the occurrence of multiple ionization for /sup 10/B bombardment of target elements in the range 21 less than or equal to Z/sub 2/ less than or equal to 28.

  17. Multiple sclerosis

    DEFF Research Database (Denmark)

    Stenager, Egon; Stenager, E N; Knudsen, Lone

    1994-01-01

    In a cross-sectional study of 117 randomly selected patients (52 men, 65 women) with definite multiple sclerosis, it was found that 76 percent were married or cohabitant, 8 percent divorced. Social contacts remained unchanged for 70 percent, but outgoing social contacts were reduced for 45 percent......, need for structural changes in home and need for pension became greater with increasing physical handicap. No significant differences between gender were found. It is concluded that patients and relatives are under increased social strain, when multiple sclerosis progresses to a moderate handicap...

  18. Multiple myeloma

    International Nuclear Information System (INIS)

    Sohn, Jeong Ick; Ha, Choon Ho; Choi, Karp Shik

    1994-01-01

    Multiple myeloma is a malignant plasma cell tumor that is thought to originate proliferation of a single clone of abnormal plasma cell resulting production of a whole monoclonal paraprotein. The authors experienced a case of multiple myeloma with severe mandibular osteolytic lesions in 46-year-old female. As a result of careful analysis of clinical, radiological, histopathological features, and laboratory findings, we diagnosed it as multiple myeloma, and the following results were obtained. 1. Main clinical symptoms were intermittent dull pain on the mandibular body area, abnormal sensation of lip and pain due to the fracture on the right clavicle. 2. Laboratory findings revealed M-spike, reversed serum albumin-globulin ratio, markedly elevated ESR and hypercalcemia. 3. Radiographically, multiple osteolytic punched-out radiolucencies were evident on the skull, zygoma, jaw bones, ribs, clavicle and upper extremities. Enlarged liver and increased uptakes on the lesional sites in RN scan were also observed. 4. Histopathologically, markedly hypercellular marrow with sheets of plasmoblasts and megakaryocytes were also observed.

  19. Multiple sclerosis

    DEFF Research Database (Denmark)

    Stenager, E; Jensen, K

    1988-01-01

    Forty-two (12%) of a total of 366 patients with multiple sclerosis (MS) had psychiatric admissions. Of these, 34 (81%) had their first psychiatric admission in conjunction with or after the onset of MS. Classification by psychiatric diagnosis showed that there was a significant positive correlation...

  20. Multiple sclerosis

    DEFF Research Database (Denmark)

    Stenager, E; Knudsen, L; Jensen, K

    1991-01-01

    In a cross-sectional investigation of 116 patients with multiple sclerosis, the social and sparetime activities of the patient were assessed by both patient and his/her family. The assessments were correlated to physical disability which showed that particularly those who were moderately disabled...

  1. Multiple sclerosis

    DEFF Research Database (Denmark)

    Stenager, E; Jensen, K

    1990-01-01

    An investigation on the correlation between ability to read TV subtitles and the duration of visual evoked potential (VEP) latency in 14 patients with definite multiple sclerosis (MS), indicated that VEP latency in patients unable to read the TV subtitles was significantly delayed in comparison...

  2. Multiple sclerosis

    DEFF Research Database (Denmark)

    Stenager, E; Knudsen, L; Jensen, K

    1994-01-01

    In a cross-sectional study of 94 patients (42 males, 52 females) with definite multiple sclerosis (MS) in the age range 25-55 years, the correlation of neuropsychological tests with the ability to read TV-subtitles and with the use of sedatives is examined. A logistic regression analysis reveals...

  3. Multiple Sclerosis.

    Science.gov (United States)

    Plummer, Nancy; Michael, Nancy, Ed.

    This module on multiple sclerosis is intended for use in inservice or continuing education programs for persons who administer medications in long-term care facilities. Instructor information, including teaching suggestions, and a listing of recommended audiovisual materials and their sources appear first. The module goal and objectives are then…

  4. Parenting Multiples

    Science.gov (United States)

    ... when your babies do. Though it can be hard to let go of the thousand other things you need to do, remember that your well-being is key to your ability to take care of your babies. What Problems Can Happen? It may be hard to tell multiple babies apart when they first ...

  5. Treatment of Cognitive Impairment in Multiple Sclerosis

    OpenAIRE

    Pierson, Susan H.; Griffith, Nathan

    2006-01-01

    Cognitive impairment in multiple sclerosis is an increasingly recognized entity. This article reviews the cognitive impairment of multiple sclerosis, its prevalence, its relationship to different types of multiple sclerosis, and its contribution to long-term functional prognosis. The discussion also focuses on the key elements of cognitive dysfunction in multiple sclerosis which distinguish it from other forms of cognitive impairment. Therapeutic interventions potentially effective for the co...

  6. System and method for image registration of multiple video streams

    Science.gov (United States)

    Dillavou, Marcus W.; Shum, Phillip Corey; Guthrie, Baron L.; Shenai, Mahesh B.; Deaton, Drew Steven; May, Matthew Benton

    2018-02-06

    Provided herein are methods and systems for image registration from multiple sources. A method for image registration includes rendering a common field of interest that reflects a presence of a plurality of elements, wherein at least one of the elements is a remote element located remotely from another of the elements and updating the common field of interest such that the presence of the at least one of the elements is registered relative to another of the elements.

  7. Synthesis and properties of neutron deficient isotopes of elements around Z=100

    International Nuclear Information System (INIS)

    Antalic, S.

    2005-01-01

    In the presented Thesis work the results of spectroscopic studies of 246 Md, 247 Md, 254 Lr and 255 Lr decay chains are given. These isotopes were produced using heavy ion induced fusion reactions of 40 Ar + 209 Bi and 48 Ca + 209 Bi as a part of the long term project aimed to study spectroscopy properties of superheavy elements. The experiments were performed at velocity filter SHIP, placed at the central beam line of the UNILAC accelerator at GSI Darmstadt in Germany. The work also gives a basic overview of research in the region of superheavy elements, description of the used experimental setup and shows the usual analysis methods used in spectroscopic studies in the region of elements around Z ∼ 100. The results were obtained using α, α - γ spectroscopy methods and recoil - α, α - α correlations search. Although these isotopes have been known for a longer time, no detailed spectroscopy investigation were performed so far and only rough information was known. Beside the improved precision of known data, this work gives a new information about the decay properties of these isotopes. This give us the possibility to build a decay schemes for mentioned decay chains. (author)

  8. Multiple photon resonances

    International Nuclear Information System (INIS)

    Elliott, C.J.; Feldman, B.J.

    1979-02-01

    A detailed theoretical analysis is presented of the interaction of intense near-resonant monochromatic radiation with an N-level anharmonic oscillator. In particular, the phenomenon of multiple photon resonance, the process by which an N-level system resonantly absorbs two or more photons simultaneously, is investigated. Starting from the Schroedinger equation, diagrammatic techniques are developed that allow the resonant process to be analyzed quantitatively, in analogy with well-known two-level coherent phenomena. In addition, multiple photon Stark shifts of the resonances, shifts absent in two-level theory, are obtained from the diagrams. Insights into the nature of multiple photon resonances are gained by comparing the quantum mechanical system with classical coupled pendulums whose equations of motion possess identical eigenvalues and eigenvectors. In certain limiting cases, including that of the resonantly excited N-level harmonic oscillator and that of the equally spaced N-level system with equal matrix elements, analytic results are derived. The influence of population relaxation and phase-disrupting collisions on the multiple photon process are also analyzed, the latter by extension of the diagrammatic technique to the density matrix equations of motion. 11 figures

  9. Multiple sclerosis

    International Nuclear Information System (INIS)

    Sadashima, Hiromichi; Kusaka, Hirofumi; Imai, Terukuni; Takahashi, Ryosuke; Matsumoto, Sadayuki; Yamamoto, Toru; Yamasaki, Masahiro; Maya, Kiyomi

    1986-01-01

    Eleven patients with a definite diagnosis of multiple sclerosis were examined in terms of correlations between the clinical features and the results of cranial computed tomography (CT), and magnetic resonance imaging (MRI). Results: In 5 of the 11 patients, both CT and MRI demonstrated lesions consistent with a finding of multiple sclerosis. In 3 patients, only MRI demonstrated lesions. In the remaining 3 patients, neither CT nor MRI revealed any lesion in the brain. All 5 patients who showed abnormal findings on both CT and MRI had clinical signs either of cerebral or brainstem - cerebellar lesions. On the other hand, two of the 3 patients with normal CT and MRI findings had optic-nerve and spinal-cord signs. Therefore, our results suggested relatively good correlations between the clinical features, CT, and MRI. MRI revealed cerebral lesions in two of the four patients with clinical signs of only optic-nerve and spinal-cord lesions. MRI demonstrated sclerotic lesions in 3 of the 6 patients whose plaques were not detected by CT. In conclusion, MRI proved to be more helpful in the demonstration of lesions attributable to chronic multiple sclerosis. (author)

  10. Discrete Element Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Morris, J; Johnson, S

    2007-12-03

    The Distinct Element Method (also frequently referred to as the Discrete Element Method) (DEM) is a Lagrangian numerical technique where the computational domain consists of discrete solid elements which interact via compliant contacts. This can be contrasted with Finite Element Methods where the computational domain is assumed to represent a continuum (although many modern implementations of the FEM can accommodate some Distinct Element capabilities). Often the terms Discrete Element Method and Distinct Element Method are used interchangeably in the literature, although Cundall and Hart (1992) suggested that Discrete Element Methods should be a more inclusive term covering Distinct Element Methods, Displacement Discontinuity Analysis and Modal Methods. In this work, DEM specifically refers to the Distinct Element Method, where the discrete elements interact via compliant contacts, in contrast with Displacement Discontinuity Analysis where the contacts are rigid and all compliance is taken up by the adjacent intact material.

  11. Chemistry of the elements

    International Nuclear Information System (INIS)

    Greenwood, N.N.; Earnshaw, A.

    1984-01-01

    This textbook presents an account of the chemistry of the elements for both undergraduate and postgraduate students. It covers not only the 'inorganic' chemistry of the elements, but also analytical, theoretical, industrial, organometallic;, bio-inorganic and other areas of chemistry which apply. The following elements of special nuclear interest are included: Rb, Cs, Fr, Sr, Ba, Ra, Po, At, Rn, Sc, Y, Zr, Hf, V, Nb, Ta, Mo, Tc, Ru, the Lanthanide Elements, the Actinide Elements. (U.K.)

  12. Multiple inflation

    International Nuclear Information System (INIS)

    Murphy, P.J.

    1987-01-01

    The Theory of Inflation, namely, that at some point the entropy content of the universe was greatly increased, has much promise. It may solve the puzzles of homogeneity and the creation of structure. However, no particle physics model has yet been found that can successfully drive inflation. The difficulty in satisfying the constraint that the isotropy of the microwave background places on the effective potential of prospective models is immense. In this work we have codified the requirements of such models in a most general form. We have carefully calculated the amounts of inflation the various problems of the Standard Model need for their solution. We have derived a completely model independent upper bond on the inflationary Hubble parameter. We have developed a general notation with which to probe the possibilities of Multiple Inflation. We have shown that only in very unlikely circumstances will any evidence of an earlier inflation, survive the de Sitter period of its successor. In particular, it is demonstrated that it is most unlikely that two bouts of inflation will yield high amplitudes of density perturbations on small scales and low amplitudes on large. We conclude that, while multiple inflation will be of great theoretical interest, it is unlikely to have any observational impact

  13. Elemental concentration analysis in the brain of young and old Wistar rats by total reflection X-ray fluorescence spectrometry

    International Nuclear Information System (INIS)

    Serpa, Renata F.B.; Jesus, Edgar F.O. de; Lopes, Ricardo T.; Anjos, Marcelino J. dos; Carmo, Maria G.T. do; Rocha, Monica S.; Moreira, Silvana; Martinez, Ana M.B.

    2007-01-01

    It is well known that aging is associated with neurobehavioral deficits. The aging process of human brain is characterized by progressive neuronal loss. Furthermore, certain brain areas are more vulnerable to neuronal degeneration than others, reflecting an altered resistance to stress of the tissue itself and/or the lack of adequate immunological defense mechanisms in these regions. About the elemental levels in the brain, it is known that the excess ou deficiency of some elements are toxic for human healthy, being also related to several neurodegenerative diseases. In this way, the main goal of this work was to determine the elemental concentration in the hippocampus of young and old male (n = 10) and female (n = 10) Wistar rats by total reflection X-ray fluorescence spectrometry with synchrotron radiation (SR-TXRF). These measurements were carried out at XRF beam line at Light Synchrotron Brazilian Laboratory, Campinas, Brazil. About the results, we could observe that Al, Fe, Cu, Zn and Br levels were higher in the hippocampus of the old female rats than the young ones. On the other hand, only Cu levels were higher in the hippocampus of the old male rats than the young ones. Therefore, the aging of the hippocampus of the female rats can be characterized by an accumulate for Al, Fe, Cu, Zn and Br. The excess in these elements levels are also associated with several neurodegenerative disorders, such as Alzheimer' disease, Parkinson's disease and Huntington's disease. (author)

  14. Trace elements status of pulmonary tuberculosis patients compared with healthy voluntaries

    International Nuclear Information System (INIS)

    Moraes, Milena L. de; Ramalho, Daniela M.P.; Delogo, Karina N.; Miranda, Pryscila F.C.; Mesquita, Eliene D.D.; Kritski, Afranio L.; Oliveira, Martha M.; Canellas, Catarine G.L.; Lopes, Ricardo T.; Anjos, Marcelino J.

    2011-01-01

    Trace elements have important contribution to immune function. The objective of this study was to compare the Iron, Copper and Zinc levels of patients with active Pulmonary Tuberculosis (TB) and healthy subjects using X-ray Total Reflection Fluorescence Spectrometry. The study group was formed by men with active TB hospitalized on the Ary Parreiras State Institute of diseases of the chest and on the Santa Maria State Hospital, Rio de Janeiro, Brazil. The control group was formed by healthy men of Military Academy Fire Dom Pedro II, Rio de Janeiro, Brazil. The measurements of trace elements were performed at XRF beam line at Brazilian Synchrotron Light, Campinas, Sao Paulo. The results show that serum iron concentration was higher in control group than in study group. Besides that, serum copper concentration was higher in control group than in study group. According to the literature higher levels of copper are observed in infectious diseases like tuberculosis. In the case of the serum zinc concentration no statistical difference was observed between the two groups studied. (author)

  15. Cognitive impairment related changes in the elemental concentration in the brain of old rat

    Energy Technology Data Exchange (ETDEWEB)

    Serpa, R.F.B. [Federal University of Rio de Janeiro/COPPE, Nuclear Instrumentation Laboratory, P.O. Box: 68509, Zip Code: 21941-972, Rio de Janeiro (Brazil)]. E-mail: renata@lin.ufrj.br; Jesus, E.F.O. de [University of Rio de Janeiro State, Physics Institute, RJ (Brazil); Anjos, M.J. [Federal University of Rio de Janeiro/COPPE, Nuclear Instrumentation Laboratory, P.O. Box: 68509, Zip Code: 21941-972, Rio de Janeiro (Brazil); University of Rio de Janeiro State, Physics Institute, RJ (Brazil); Lopes, R.T. [Federal University of Rio de Janeiro/COPPE, Nuclear Instrumentation Laboratory, P.O. Box: 68509, Zip Code: 21941-972, Rio de Janeiro (Brazil); Carmo, M.G.T. do [Federal University of Rio de Janeiro, Nutrition Institute, RJ (Brazil); Rocha, M.S. [Federal University of Rio de Janeiro, Department of Basics and Clinic Pharmacy, RJ (Brazil); Rodrigues, L.C. [Federal University of Rio de Janeiro, Department of Basics and Clinic Pharmacy, RJ (Brazil); Moreira, S. [University of Campinas State, Civil Engineering Department, SP (Brazil); Martinez, A.M.B. [Federal University of Rio de Janeiro, Department of Histology and Embryology, RJ (Brazil)

    2006-11-15

    In order to evaluate the elemental concentration as a function of learning and memory deficiency, six different structures of the brain were analyzed by total reflection X-ray fluorescence spectrometry with synchrotron radiation (SR-TXRF). To evaluate the cognitive processes, the animals were tested in an adaptation of the Morris water maze. After the test, the animals were divided into two groups: cognitively healthy (control group) and cognitively impaired. The measurements were carried out at XRF beam line at Light Synchrotron Brazilian laboratory, Campinas, Brazil. The following elements were identified: Al, P, S, Cl, K, Ca, Ti, Cr, Fe, Cu, Zn, Br and Rb. K concentration was higher in all regions of the brain studied for control group than the cognitively impaired group. Moreover, the control group presented higher levels for P and Fe in the entorhinal cortex, in the temporal cortex (only P), in the hypothalamus and in the thalamus, than the cognitively impaired group. Br concentration in the animals which presented cognitive impairment was three times larger in the hypothalamus and thalamus, twice larger in temporal cortex and higher in visual cortex than the cognitively healthy group. Cu was more remarkable in the hippocampus and hypothalamus from the animals with cognitive impairment than the control group. We observed that the cognitively impaired group presented highest concentrations of Br and Cu in certain areas than the control group, on the other hand, this group presented highest levels of K for all brain areas studied.

  16. Cognitive impairment related changes in the elemental concentration in the brain of old rat

    International Nuclear Information System (INIS)

    Serpa, R.F.B.; Jesus, E.F.O. de; Anjos, M.J.; Lopes, R.T.; Carmo, M.G.T. do; Rocha, M.S.; Rodrigues, L.C.; Moreira, S.; Martinez, A.M.B.

    2006-01-01

    In order to evaluate the elemental concentration as a function of learning and memory deficiency, six different structures of the brain were analyzed by total reflection X-ray fluorescence spectrometry with synchrotron radiation (SR-TXRF). To evaluate the cognitive processes, the animals were tested in an adaptation of the Morris water maze. After the test, the animals were divided into two groups: cognitively healthy (control group) and cognitively impaired. The measurements were carried out at XRF beam line at Light Synchrotron Brazilian laboratory, Campinas, Brazil. The following elements were identified: Al, P, S, Cl, K, Ca, Ti, Cr, Fe, Cu, Zn, Br and Rb. K concentration was higher in all regions of the brain studied for control group than the cognitively impaired group. Moreover, the control group presented higher levels for P and Fe in the entorhinal cortex, in the temporal cortex (only P), in the hypothalamus and in the thalamus, than the cognitively impaired group. Br concentration in the animals which presented cognitive impairment was three times larger in the hypothalamus and thalamus, twice larger in temporal cortex and higher in visual cortex than the cognitively healthy group. Cu was more remarkable in the hippocampus and hypothalamus from the animals with cognitive impairment than the control group. We observed that the cognitively impaired group presented highest concentrations of Br and Cu in certain areas than the control group, on the other hand, this group presented highest levels of K for all brain areas studied

  17. Trace elements status of pulmonary tuberculosis patients compared with healthy voluntaries

    Energy Technology Data Exchange (ETDEWEB)

    Moraes, Milena L. de; Ramalho, Daniela M.P.; Delogo, Karina N.; Miranda, Pryscila F.C.; Mesquita, Eliene D.D.; Kritski, Afranio L.; Oliveira, Martha M. [Centro de Pesquisa em Tuberculose, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, RJ (Brazil); Canellas, Catarine G.L.; Lopes, Ricardo T., E-mail: ricardo@lin.ufrj.br [Laboratorio de Instrumentacao Nuclear, Programa de Engenharia Nuclear/COPPE UFRJ, RJ (Brazil); Anjos, Marcelino J., E-mail: marcelin@uerj.br [Departamento de Fisica Aplicada e Termodinamica - Instituto de Fisica Armando Dias Tavares. Universidade do Estado do Rio de Janeiro, RJ (Brazil)

    2011-07-01

    Trace elements have important contribution to immune function. The objective of this study was to compare the Iron, Copper and Zinc levels of patients with active Pulmonary Tuberculosis (TB) and healthy subjects using X-ray Total Reflection Fluorescence Spectrometry. The study group was formed by men with active TB hospitalized on the Ary Parreiras State Institute of diseases of the chest and on the Santa Maria State Hospital, Rio de Janeiro, Brazil. The control group was formed by healthy men of Military Academy Fire Dom Pedro II, Rio de Janeiro, Brazil. The measurements of trace elements were performed at XRF beam line at Brazilian Synchrotron Light, Campinas, Sao Paulo. The results show that serum iron concentration was higher in control group than in study group. Besides that, serum copper concentration was higher in control group than in study group. According to the literature higher levels of copper are observed in infectious diseases like tuberculosis. In the case of the serum zinc concentration no statistical difference was observed between the two groups studied. (author)

  18. Treatment of Cognitive Impairment in Multiple Sclerosis

    Science.gov (United States)

    Pierson, Susan H.; Griffith, Nathan

    2006-01-01

    Cognitive impairment in multiple sclerosis is an increasingly recognized entity. This article reviews the cognitive impairment of multiple sclerosis, its prevalence, its relationship to different types of multiple sclerosis, and its contribution to long-term functional prognosis. The discussion also focuses on the key elements of cognitive dysfunction in multiple sclerosis which distinguish it from other forms of cognitive impairment. Therapeutic interventions potentially effective for the cognitive impairment of multiple sclerosis are reviewed including the effects of disease modifying therapies and the use of physical and cognitive interventions. PMID:16720960

  19. Data Element Registry Services

    Data.gov (United States)

    U.S. Environmental Protection Agency — Data Element Registry Services (DERS) is a resource for information about value lists (aka code sets / pick lists), data dictionaries, data elements, and EPA data...

  20. A Code Division Technique for Multiple Element Synthetic Aperture Transmission

    DEFF Research Database (Denmark)

    Gran, Fredrik; Jensen, Jørgen Arendt; Jakobsson, Andreas

    2004-01-01

    a method in which all transmitting centers can be excited at the same time and separated at the receiver. Hereby the benefits from traditional STA can be utilized and a high fframe rate can be maintained and the images are not influenced by motion artifacts. The different centers are excited using mutually...

  1. Radiolabelled cellular blood elements

    International Nuclear Information System (INIS)

    Sinzinger, H.

    1990-01-01

    This book reports on radiolabelled cellular blood elements, covering new advances made during the past several years, in particular the use of Tc-99 as a tracer for blood elements. Coverage extends to several radiolabelled monoclonal antibodies that are specific for blood components and may label blood elements in vivo

  2. Concentration of stable elements in food products

    International Nuclear Information System (INIS)

    Montford, M.A.; Shank, K.E.; Hendricks, C.; Oakes, T.W.

    1980-01-01

    Food samples were taken from commercial markets and analyzed for stable element content. The concentrations of most stable elements (Ag, Al, As, Au, Ba, Br, Ca, Ce, Cl, Co, Cr, Cs, Cu, Fe, Hf, I, K, La, Mg, Mn, Mo, Na, Rb, Sb, Sc, Se, Sr, Ta, Th, Ti, V, Zn, Zr) were determined using multiple-element neutron activation analysis, while the concentrations of other elements (Cd, Hg, Ni, Pb) were determined using atomic absorption. The relevance of the concentrations found are noted in relation to other literature values. An earlier study was extended to include the determination of the concentration of stable elements in home-grown products in the vicinity of the Oak Ridge National Laboratory. Comparisons between the commercial and local food-stuff values are discussed

  3. Rare (Earth Elements [score

    Directory of Open Access Journals (Sweden)

    Camilo Méndez

    2014-12-01

    Full Text Available Rare (Earth Elements is a cycle of works for solo piano. The cycle was inspired by James Dillon’s Book of Elements (Vol. I-V. The complete cycle will consist of 14 pieces; one for each selected rare (earth element. The chosen elements are Neodymium, Erbium, Tellurium, Hafnium, Tantalum, Technetium, Indium, Dysprosium, Lanthanium, Cerium, Europium, Terbium, Yttrium and Darmstadtium. These elements were selected due to their special atomic properties that in many cases make them extremely valuable for the development of new technologies, and also because of their scarcity. To date, only 4 works have been completed Yttrium, Technetium, Indium and Tellurium.

  4. Generalized finite elements

    International Nuclear Information System (INIS)

    Wachspress, E.

    2009-01-01

    Triangles and rectangles are the ubiquitous elements in finite element studies. Only these elements admit polynomial basis functions. Rational functions provide a basis for elements having any number of straight and curved sides. Numerical complexities initially associated with rational bases precluded extensive use. Recent analysis has reduced these difficulties and programs have been written to illustrate effectiveness. Although incorporation in major finite element software requires considerable effort, there are advantages in some applications which warrant implementation. An outline of the basic theory and of recent innovations is presented here. (authors)

  5. Elements beyond uranium

    International Nuclear Information System (INIS)

    Seaborg, G.T.; Loveland, W.D.

    1990-01-01

    This book is the 12th volume in a series on transuranium elements. Varied techniques for production of these elements, the methods used in the identification, and the exquisitely refined microchemical techniques required to deal wth samples sometimes involving only a few atoms are described in detail. The chapter on synthesis of the new elements is liberally laced with reminiscences of the proud progenitors as well as the criteria for the discovery of a new chemical element. The authors lament that the superheavy elements (elements in the region of atomic number 114) still elude detection even though their creation should be possible, and some, at least, should survive long enough to be detected. One chapter in the book is devoted to practical applictions of uranium, and the transuranic elements

  6. Limitless Analytic Elements

    Science.gov (United States)

    Strack, O. D. L.

    2018-02-01

    We present equations for new limitless analytic line elements. These elements possess a virtually unlimited number of degrees of freedom. We apply these new limitless analytic elements to head-specified boundaries and to problems with inhomogeneities in hydraulic conductivity. Applications of these new analytic elements to practical problems involving head-specified boundaries require the solution of a very large number of equations. To make the new elements useful in practice, an efficient iterative scheme is required. We present an improved version of the scheme presented by Bandilla et al. (2007), based on the application of Cauchy integrals. The limitless analytic elements are useful when modeling strings of elements, rivers for example, where local conditions are difficult to model, e.g., when a well is close to a river. The solution of such problems is facilitated by increasing the order of the elements to obtain a good solution. This makes it unnecessary to resort to dividing the element in question into many smaller elements to obtain a satisfactory solution.

  7. The solar element

    DEFF Research Database (Denmark)

    Kragh, Helge

    2009-01-01

    of the nineteenth century. In the modest form of a yellow spectral line known as D3, 'helium' was sometimes supposed to exist in the Sun's atmosphere, an idea which is traditionally ascribed to J. Norman Lockyer. Did Lockyer discover helium as a solar element? How was the suggestion received by chemists, physicists...... and astronomers in the period until the spring of 1895, when William Ramsay serendipitously found the gas in uranium minerals? The hypothetical element helium was fairly well known, yet Ramsay's discovery owed little or nothing to Lockyer's solar element. Indeed, for a brief while it was thought that the two...... elements might be different. The complex story of how helium became established as both a solar and terrestrial element involves precise observations as well as airy speculations. It is a story that is unique among the discovery histories of the chemical elements....

  8. The synthetic elements

    Energy Technology Data Exchange (ETDEWEB)

    Hoffman, D.C.

    1990-05-01

    Prior to 1940, the heaviest element known was uranium, discovered in 1789. Since that time the elements 93 through 109 have been synthesized and identified and the elements 43, 61, 85, and 87 which were missing form the periodic tables of the 1930's have been discovered. The techniques and problems involved in these discoveries and the placement of the transuranium elements in the periodic table will be discussed. The production and positive identification of elements heavier than Md (Z=101), which have very short half-lives and can only be produced an atom-at-a-time, are very difficult and there have been controversies concerning their discovery. Some of the new methods which have been developed and used in these studies will be described. The prospects for production of still heavier elements will be considered.

  9. The synthetic elements

    International Nuclear Information System (INIS)

    Hoffman, D.C.

    1990-05-01

    Prior to 1940, the heaviest element known was uranium, discovered in 1789. Since that time the elements 93 through 109 have been synthesized and identified and the elements 43, 61, 85, and 87 which were missing form the periodic tables of the 1930's have been discovered. The techniques and problems involved in these discoveries and the placement of the transuranium elements in the periodic table will be discussed. The production and positive identification of elements heavier than Md (Z=101), which have very short half-lives and can only be produced an atom-at-a-time, are very difficult and there have been controversies concerning their discovery. Some of the new methods which have been developed and used in these studies will be described. The prospects for production of still heavier elements will be considered

  10. Fuel element loading system

    International Nuclear Information System (INIS)

    Arya, S.P; s.

    1978-01-01

    A nuclear fuel element loading system is described which conveys a plurality of fuel rods to longitudinal passages in fuel elements. Conveyor means successively position the fuel rods above the longitudinal passages in axial alignment therewith and adapter means guide the fuel rods from the conveyor means into the longitudinal passages. The fuel elements are vibrated to cause the fuel rods to fall into the longitudinal passages through the adapter means

  11. Elements in biological AMS

    International Nuclear Information System (INIS)

    Vogel, J.S.; McAninch, J.; Freeman, S.

    1996-08-01

    AMS (Accelerator Mass Spectrometry) provides high detection sensitivity for isotopes whose half-lives are between 10 years and 100 million years. 14 C is the most developed of such isotopes and is used in tracing natural and anthropogenic organic compounds in the Earth's biosphere. Thirty-three elements in the main periodic table and 17 lanthanides or actinides have long lived isotopes, providing potential tracers for research in elemental biochemistry. Overlap of biologically interesting heavy elements and possible AMS tracers is discussed

  12. Analogs for transuranic elements

    International Nuclear Information System (INIS)

    Weimer, W.C.; Laul, J.C.; Kutt, J.C.

    1981-01-01

    A combined theoretical and experimental approach is being used to estimate the long-term environmental and biogeochemical behaviors of selected transuranic elements. The objective of this research is to estimate the effect that long-term (hundreds of years) environmental weathering has on the behavior of the transuranic elements americium and curium. This is achieved by investigating the actual behavior of naturally occurring rare earth elements, especially neodymium, that serve as transuranic analogs. Determination of the analog element behavior provides data that can be used to estimate the ultimate availability to man of transuranic materials released into the environment

  13. Chemistry of superheavy elements

    International Nuclear Information System (INIS)

    Schaedel, M.

    2012-01-01

    The chemistry of superheavy elements - or transactinides from their position in the Periodic Table - is summarized. After giving an overview over historical developments, nuclear aspects about synthesis of neutron-rich isotopes of these elements, produced in hot-fusion reactions, and their nuclear decay properties are briefly mentioned. Specific requirements to cope with the one-atom-at-a-time situation in automated chemical separations and recent developments in aqueous-phase and gas-phase chemistry are presented. Exciting, current developments, first applications, and future prospects of chemical separations behind physical recoil separators ('pre-separator') are discussed in detail. The status of our current knowledge about the chemistry of rutherfordium (Rf, element 104), dubnium (Db, element 105), seaborgium (Sg, element 106), bohrium (Bh, element 107), hassium (Hs, element 108), copernicium (Cn, element 112), and element 114 is discussed from an experimental point of view. Recent results are emphasized and compared with empirical extrapolations and with fully-relativistic theoretical calculations, especially also under the aspect of the architecture of the Periodic Table. (orig.)

  14. Seagrass leaf element content

    NARCIS (Netherlands)

    Vonk, J.A.; Smulders, Fee O.H.; Christianen, Marjolijn J.A.; Govers, Laura L.

    2017-01-01

    Knowledge on the role of seagrass leaf elements and in particular micronutrients and their ranges is limited. We present a global database, consisting of 1126 unique leaf values for ten elements, obtained from literature and unpublished data, spanning 25 different seagrass species from 28 countries.

  15. Berkeley new element program

    International Nuclear Information System (INIS)

    Ghiorso, A.

    1975-09-01

    The work done with element 106 is reviewed, and a new experiment which bears on the properties of the isotope of mass 260 with atomic number 104 is discussed. It is noted that in the case of element 106 a link is demonstrated to the granddaughter as well as the daughter

  16. Elemental Food for Thought

    Science.gov (United States)

    Cady, Susan

    2005-01-01

    One of the first tasks students learn in chemistry is to pronounce and spell the names of elements and learn their corresponding chemical symbols. Repetitive oral recitation is commonly used to learn this information, but games and puzzles can make this task creative, variable, and fun. Elemental Food for Thought is a puzzlelike activity that…

  17. Nuclear fuel element

    International Nuclear Information System (INIS)

    Mogard, J.H.

    1977-01-01

    A nuclear fuel element is disclosed for use in power producing nuclear reactors, comprising a plurality of axially aligned ceramic cylindrical fuel bodies of the sintered type, and a cladding tube of metal or metal alloys, wherein said cladding tube on its cylindrical inner surface is provided with a plurality of slightly protruding spacing elements distributed over said inner surface

  18. Proceedings of transuranium elements

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    The identification of the first synthetic elements was established by chemical evidence. Conclusive proof of the synthesis of the first artificial element, technetium, was published in 1937 by Perrier and Segre. An essential aspect of their achievement was the prediction of the chemical properties of element 43, which had been missing from the periodic table and which was expected to have properties similar to those of manganese and rhenium. The discovery of other artificial elements, astatine and francium, was facilitated in 1939-1940 by the prediction of their chemical properties. A little more than 50 years ago, in the spring of 1940, Edwin McMillan and Philip Abelson synthesized element 93, neptunium, and confirmed its uniqueness by chemical means. On August 30, 1940, Glenn Seaborg, Arthur Wahl, and the late Joseph Kennedy began their neutron irradiations of uranium nitrate hexahydrate. A few months later they synthesized element 94, later named plutonium, by observing the alpha particles emitted from uranium oxide targets that had been bombarded with deuterons. Shortly thereafter they proved that is was the second transuranium element by establishing its unique oxidation-reduction behavior. The symposium honored the scientists and engineers whose vision and dedication led to the discovery of the transuranium elements and to the understanding of the influence of 5f electrons on their electronic structure and bonding. This volume represents a record of papers presented at the symposium

  19. Scintillating anticoincidence detection elements design and tests with muons and protons

    International Nuclear Information System (INIS)

    Gilliot, M.; Chabaud, J.; Baronick, J.P.; Colonges, S.; Laurent, P.

    2010-01-01

    Design, construction and tests of anticoincidence detection elements are presented. Initially planned to be used as active shielding parts of the anticoincidence detector of the Simbol-X mission, they are aimed to detect cosmic protons and provide veto signal against charged-particle background induced on imaging detectors. The sample is made of a scintillator plate into which grooves are machined and waveshifting fibers glued. The fibers are connected to multianode photomultiplier (PM) tubes. The tubes characteristics have been evaluated for this application. The device has been tested with atmospheric muons that deposit similar energy to that of cosmic protons thanks to a specially designed muon telescope also described in this paper. Tests have also been performed with protons of a tandem accelerator beam line. The response is on average above 10 photoelectrons, which is not complicated to detect, which allows very good detection efficiency as well as very good ability to reject noise. In addition many evolution and performance improvements appear possible.

  20. Scintillating anticoincidence detection elements design and tests with muons and protons

    Science.gov (United States)

    Gilliot, M.; Chabaud, J.; Baronick, J. P.; Colonges, S.; Laurent, P.

    2010-09-01

    Design, construction and tests of anticoincidence detection elements are presented. Initially planned to be used as active shielding parts of the anticoincidence detector of the Simbol-X mission, they are aimed to detect cosmic protons and provide veto signal against charged-particle background induced on imaging detectors. The sample is made of a scintillator plate into which grooves are machined and waveshifting fibers glued. The fibers are connected to multianode photomultiplier (PM) tubes. The tubes characteristics have been evaluated for this application. The device has been tested with atmospheric muons that deposit similar energy to that of cosmic protons thanks to a specially designed muon telescope also described in this paper. Tests have also been performed with protons of a tandem accelerator beam line. The response is on average above 10 photoelectrons, which is not complicated to detect, which allows very good detection efficiency as well as very good ability to reject noise. In addition many evolution and performance improvements appear possible.

  1. Scintillating anticoincidence detection elements design and tests with muons and protons

    Energy Technology Data Exchange (ETDEWEB)

    Gilliot, M., E-mail: mickael.gilliot@univ-reims.f [Laboratoire APC, AstroParticules and Cosmologie, Batiment Condorcet, 10 rue Alice Domont et Leonie Duquet, 75205 Paris Cedex 13 (France); Chabaud, J.; Baronick, J.P.; Colonges, S. [Laboratoire APC, AstroParticules and Cosmologie, Batiment Condorcet, 10 rue Alice Domont et Leonie Duquet, 75205 Paris Cedex 13 (France); Laurent, P. [Laboratoire APC, AstroParticules and Cosmologie, Batiment Condorcet, 10 rue Alice Domont et Leonie Duquet, 75205 Paris Cedex 13 (France); CEA/DSM/Irfu/SAp, CEA/Saclay, 91191 Gif-Sur-Yvette Cedex (France)

    2010-09-21

    Design, construction and tests of anticoincidence detection elements are presented. Initially planned to be used as active shielding parts of the anticoincidence detector of the Simbol-X mission, they are aimed to detect cosmic protons and provide veto signal against charged-particle background induced on imaging detectors. The sample is made of a scintillator plate into which grooves are machined and waveshifting fibers glued. The fibers are connected to multianode photomultiplier (PM) tubes. The tubes characteristics have been evaluated for this application. The device has been tested with atmospheric muons that deposit similar energy to that of cosmic protons thanks to a specially designed muon telescope also described in this paper. Tests have also been performed with protons of a tandem accelerator beam line. The response is on average above 10 photoelectrons, which is not complicated to detect, which allows very good detection efficiency as well as very good ability to reject noise. In addition many evolution and performance improvements appear possible.

  2. Multiple Input - Multiple Output (MIMO) SAR

    Data.gov (United States)

    National Aeronautics and Space Administration — This effort will research and implement advanced Multiple-Input Multiple-Output (MIMO) Synthetic Aperture Radar (SAR) techniques which have the potential to improve...

  3. Ten key elements for implementing interprofessional learning in ...

    African Journals Online (AJOL)

    This paper discusses 10 key elements for the design and implementation of interprofessional education (IPE) in a skills centre. The elements are based on published literature as well as on the experience of an IPE initiative, simulating the management of a multiple-traumatised patient in the acute and rehabilitation phases, ...

  4. Discovery of element 112

    Energy Technology Data Exchange (ETDEWEB)

    Hofmann, S. [GSI, Darmstadt (Germany)

    1996-12-31

    The new elements 110, 111, and 112 were synthesized and unambiguously identified in experiments at SHIP. Due to strong shell effects the dominant decay mode is not fission, but emission of alpha particles. Theoretical investigations predict that maximum shell effects should exist in nuclei near proton number 114 and neutron number 184. Measurements give hope that isotopes of element 114 close to the island of spherical Superheavy Elements could be produced by fusion reactions using {sup 118}Pb as target. systematic studies of the reaction cross-sections indicate that transfer of nucleons is the important process to initiate the fusion.

  5. Elemental diffusion in stars

    International Nuclear Information System (INIS)

    Michaud, Georges; Montmerle, Thierry

    1977-01-01

    This paper is dealing with the origin of the elements in the universe. The scheme of nucleosynthesis is kept to explain the stellar generation of helium, carbon, etc... from the initial hydrogen; but a nonlinear theory is then elaborated to account for the anomalous abundances which were observed. The chemical elements would diffuse throughout the outer layers of a star under the action of the opposite forces of gravitation and radiation. This theory, with completing the nucleosynthesis, would contribute to give a consistent scheme of the elemental origin and abundances [fr

  6. Bridge element deterioration rates.

    Science.gov (United States)

    2008-10-01

    This report describes the development of bridge element deterioration rates using the NYSDOT : bridge inspection database using Markov chains and Weibull-based approaches. It is observed : that Weibull-based approach is more reliable for developing b...

  7. 2. Transuranic elements

    International Nuclear Information System (INIS)

    Anon.

    1975-01-01

    Methods of sample collection, sample storage, sample procedures and radioanalytical procedures for transuranic elements in marine environment are reviewed and recommended. Alpha spectrometry and scintillation techniques are used for measurement of isotopic content. Separation processes for samples are described

  8. Heavy element research

    International Nuclear Information System (INIS)

    Anon.

    1976-01-01

    Heavy element research activities in metallurgy and ceramics during 1976 at Lawrence Berkeley Laboratory are reviewed. Topics include: microstructure, properties and alloy design; ceramic alloy program; high resolution and high voltage electron microscopy; and powder metallurgy

  9. Nuclear reactor fuel elements

    International Nuclear Information System (INIS)

    Hindle, E.D.

    1981-01-01

    An array of rods comprising zirconium alloy sheathed nuclear fuel pellets assembled to form a fuel element for a pressurised water reactor is claimed. The helium gas pressure within each rod differs substantially from that of its closest neighbours

  10. Nuclear reactor fuel elements

    International Nuclear Information System (INIS)

    Hindle, E.D.

    1984-01-01

    The fuel elements for a pressurised water reactor comprise arrays of rods of zirconium alloy sheathed nuclear fuel pellets. The helium gas pressure within each rod differs substantially from that of its closest neighbours

  11. Transposable elements in cancer.

    Science.gov (United States)

    Burns, Kathleen H

    2017-07-01

    Transposable elements give rise to interspersed repeats, sequences that comprise most of our genomes. These mobile DNAs have been historically underappreciated - both because they have been presumed to be unimportant, and because their high copy number and variability pose unique technical challenges. Neither impediment now seems steadfast. Interest in the human mobilome has never been greater, and methods enabling its study are maturing at a fast pace. This Review describes the activity of transposable elements in human cancers, particularly long interspersed element-1 (LINE-1). LINE-1 sequences are self-propagating, protein-coding retrotransposons, and their activity results in somatically acquired insertions in cancer genomes. Altered expression of transposable elements and animation of genomic LINE-1 sequences appear to be hallmarks of cancer, and can be responsible for driving mutations in tumorigenesis.

  12. Divergent picornavirus IRES elements

    DEFF Research Database (Denmark)

    Belsham, Graham

    2009-01-01

    Internal ribosome entry site (IRES) elements were first identified about 20 years ago within the 5' untranslated region of picornavirus RNAs. They direct a cap-independent mechanism of translation initiation on the viral RNA. Within the picornavirus family it is now known that there are four...... classes of IRES element which vary in size (450-270nt), they also have different, complex, secondary structures and distinct requirements for cellular proteins to allow them to function. This review describes the features of each class of picornavirus IRES element but focuses on the characteristics...... of the most recently described group, initially identified within the porcine teschovirus-1 RNA, which has strong similarities to the IRES elements from within the genomes of hepatitis C virus and the pestiviruses which are members of the flavivirus family. The selection of the initiation codon...

  13. Novel porcine repetitive elements

    Directory of Open Access Journals (Sweden)

    Nonneman Dan J

    2006-12-01

    Full Text Available Abstract Background Repetitive elements comprise ~45% of mammalian genomes and are increasingly known to impact genomic function by contributing to the genomic architecture, by direct regulation of gene expression and by affecting genomic size, diversity and evolution. The ubiquity and increasingly understood importance of repetitive elements contribute to the need to identify and annotate them. We set out to identify previously uncharacterized repetitive DNA in the porcine genome. Once found, we characterized the prevalence of these repeats in other mammals. Results We discovered 27 repetitive elements in 220 BACs covering 1% of the porcine genome (Comparative Vertebrate Sequencing Initiative; CVSI. These repeats varied in length from 55 to 1059 nucleotides. To estimate copy numbers, we went to an independent source of data, the BAC-end sequences (Wellcome Trust Sanger Institute, covering approximately 15% of the porcine genome. Copy numbers in BAC-ends were less than one hundred for 6 repeat elements, between 100 and 1000 for 16 and between 1,000 and 10,000 for 5. Several of the repeat elements were found in the bovine genome and we have identified two with orthologous sites, indicating that these elements were present in their common ancestor. None of the repeat elements were found in primate, rodent or dog genomes. We were unable to identify any of the replication machinery common to active transposable elements in these newly identified repeats. Conclusion The presence of both orthologous and non-orthologous sites indicates that some sites existed prior to speciation and some were generated later. The identification of low to moderate copy number repetitive DNA that is specific to artiodactyls will be critical in the assembly of livestock genomes and studies of comparative genomics.

  14. Fuel element store

    International Nuclear Information System (INIS)

    Wieser, R.

    1987-01-01

    The spherical fuel elements are stored dry in cans. The cans themselves are stacked in parallel storage shafts, which are combined into a rectangular storage space. The storage space is made earthquake-proof by surrounding it with concrete. It consists of a ceiling assembled from several steel parts, which is connected to the floor by support elements. A cooling air ventilation station supplies the individual storage shaft and therefore the cans with cooling air via incoming and outgoing pipes. (DG) [de

  15. Intrusion detection system elements

    International Nuclear Information System (INIS)

    Eaton, M.J.; Mangan, D.L.

    1980-09-01

    This report highlights elements required for an intrusion detection system and discusses problems which can be encountered in attempting to make the elements effective. Topics discussed include: sensors, both for exterior detection and interior detection; alarm assessment systems, with the discussion focused on video assessment; and alarm reporting systems, including alarm communication systems and dislay/console considerations. Guidance on careful planning and design of a new or to-be-improved system is presented

  16. Structural elements design manual

    CERN Document Server

    Draycott, Trevor

    2012-01-01

    Gives clear explanations of the logical design sequence for structural elements. The Structural Engineer says: `The book explains, in simple terms, and with many examples, Code of Practice methods for sizing structural sections in timber, concrete,masonry and steel. It is the combination into one book of section sizing methods in each of these materials that makes this text so useful....Students will find this an essential support text to the Codes of Practice in their study of element sizing'.

  17. Atoms, molecules & elements

    CERN Document Server

    Graybill, George

    2007-01-01

    Young scientists will be thrilled to explore the invisible world of atoms, molecules and elements. Our resource provides ready-to-use information and activities for remedial students using simplified language and vocabulary. Students will label each part of the atom, learn what compounds are, and explore the patterns in the periodic table of elements to find calcium (Ca), chlorine (Cl), and helium (He) through hands-on activities.

  18. On-stream chemical element monitor

    International Nuclear Information System (INIS)

    Averitt, O.R.; Dorsch, R.R.

    1979-01-01

    An apparatus and method for on-stream chemical element monitoring are described wherein a multiplicity of sample streams are flowed continuously through individual analytical cells and fluorescence analyses are performed on the sample streams in sequence, together with a method of controlling the time duration of each analysis as a function of the concomitant radiation exposure of a preselected perforate reference material interposed in the sample-radiation source path

  19. Peridynamic Multiscale Finite Element Methods

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Timothy [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bond, Stephen D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Littlewood, David John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Moore, Stan Gerald [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-12-01

    The problem of computing quantum-accurate design-scale solutions to mechanics problems is rich with applications and serves as the background to modern multiscale science research. The prob- lem can be broken into component problems comprised of communicating across adjacent scales, which when strung together create a pipeline for information to travel from quantum scales to design scales. Traditionally, this involves connections between a) quantum electronic structure calculations and molecular dynamics and between b) molecular dynamics and local partial differ- ential equation models at the design scale. The second step, b), is particularly challenging since the appropriate scales of molecular dynamic and local partial differential equation models do not overlap. The peridynamic model for continuum mechanics provides an advantage in this endeavor, as the basic equations of peridynamics are valid at a wide range of scales limiting from the classical partial differential equation models valid at the design scale to the scale of molecular dynamics. In this work we focus on the development of multiscale finite element methods for the peridynamic model, in an effort to create a mathematically consistent channel for microscale information to travel from the upper limits of the molecular dynamics scale to the design scale. In particular, we first develop a Nonlocal Multiscale Finite Element Method which solves the peridynamic model at multiple scales to include microscale information at the coarse-scale. We then consider a method that solves a fine-scale peridynamic model to build element-support basis functions for a coarse- scale local partial differential equation model, called the Mixed Locality Multiscale Finite Element Method. Given decades of research and development into finite element codes for the local partial differential equation models of continuum mechanics there is a strong desire to couple local and nonlocal models to leverage the speed and state of the

  20. Fuel element transport container

    International Nuclear Information System (INIS)

    Benna, P.; Neuenfeldt, W.

    1979-01-01

    The reprocessing system includes a large number of waterfilled ponds next to each other for the intermediate storage of fuel elements from LWR's. The fuel element transport device is allocated to a middle pond. The individual ponds are separated from each other by walls, and are only accessible from the middle pond via narrow passages. The transport device includes a telescopic running rail for a trolley with a grab device for the fuel element. The running rail is supported in turn by a second trolley, which can be moved by wheels on rails. Part of the drive of the first trolley is arranged on the second one. Using this transport device, adjacent ponds can be served through the passage openings. (DG) [de

  1. Nuclear fuel element

    International Nuclear Information System (INIS)

    Hirayama, Satoshi; Kawada, Toshiyuki; Matsuzaki, Masayoshi.

    1980-01-01

    Purpose: To provide a fuel element for reducing the mechanical interactions between a fuel-cladding tube and the fuel element and for alleviating the limits of the operating conditions of a reactor. Constitution: A fuel element having mainly uranium dioxide consists of a cylindrical outer pellet and cylindrical inner pellet inserted into the outer pellet. The outer pellet contains two or more additives selected from aluminium oxide, beryllium oxide, magnesium oxide, silicon oxide, sodium oxide, phosphorus oxide, calcium oxide and iron oxide, and the inner pellet contains nuclear fuel substance solely or one additive selected from calcium oxide, silicon oxide, aluminium oxide, magnesium oxide, zirconium oxide and iron oxide. The outer pellet of the fuel thus constituted is reduced in mechanical strength and also in the mechanical interactions with the cladding tube, and the plastic fluidity of the entire pellet is prevented by the inner pellet increased in the mechanical strength. (Kamimura, M.)

  2. Creativity Management Key Elements

    Directory of Open Access Journals (Sweden)

    Rosa María Fuchs Ángeles

    2015-09-01

    Full Text Available Organizations are constantly looking towards innovation. In order to reach it they must foment creativity. This paper analyzes a series of elements considered in the organizational creativity management and proposes a model with the indispensable factors that organizations should consider to reach it. These elements are: culture and organizational environment, strategy, structure, communication, relation with customers, human resources (recruiting, training, job design, compensation, promotion, and performance evaluation, long term orientation and the organizational life cycle. Having the analysis of those elements as a basis, the indispensable pillars on management creativity are identified. The proposed model is based on 5 pillars: the alignment between strategic, culture and organizational structure, called by the authors 'Holy Trinity'; intern publicity; customer’s voice; recognition and a look towards future. Finally, the case of an innovative Peruvian enterprise is presented from the model’s perspective and the study conclusions.

  3. Fuel Element Technical Manual

    Energy Technology Data Exchange (ETDEWEB)

    Burley, H.H. [ed.

    1956-08-01

    It is the purpose of the Fuel Element Technical Manual to Provide a single document describing the fabrication processes used in the manufacture of the fuel element as well as the technical bases for these processes. The manual will be instrumental in the indoctrination of personnel new to the field and will provide a single data reference for all personnel involved in the design or manufacture of the fuel element. The material contained in this manual was assembled by members of the Engineering Department and the Manufacturing Department at the Hanford Atomic Products Operation between the dates October, 1955 and June, 1956. Arrangement of the manual. The manual is divided into six parts: Part I--introduction; Part II--technical bases; Part III--process; Part IV--plant and equipment; Part V--process control and improvement; and VI--safety.

  4. Plasmacytoma Infiltrating Leiomyoma in Multiple Myeloma

    Science.gov (United States)

    2018-01-19

    REPORT TYPE 3. DATES COVERED (From - To) 01/19/2018 Poster 01/19/2018-01/21/2018 4. TITLE AND SUBTITLE Sa. CONTRACT NUMBER Plasmacytoma...Infiltrating Leiomyoma in Multiple Myeloma Sb. GRANT NUMBER Sc. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Sd. PROJECT NUMBER Capt Eden, Rina Se. TASK NUMBER Sf

  5. Fast Output-sensitive Matrix Multiplication

    DEFF Research Database (Denmark)

    Jacob, Riko; Stöckel, Morten

    2015-01-01

    We consider the problem of multiplying two $U \\times U$ matrices $A$ and $C$ of elements from a field $\\F$. We present a new randomized algorithm that can use the known fast square matrix multiplication algorithms to perform fewer arithmetic operations than the current state of the art for output...

  6. Neutron activation analysis of trace elements in Japanese hormesis cosmetics

    International Nuclear Information System (INIS)

    Furuta, E.; Nakahara, H.; Hatsukawa, Y.; Matsue, H.; Sakane, H.

    2008-01-01

    In Japan, cosmetics claiming hormesis effect are available through Internet. Although these cosmetics show the contents, they never mention the minor elements and radioactive sources. The existence of radioisotopes, however, was observed by measurements of the gamma-rays with a HPGe detector. In this study, in order to clarify the contents of trace elements, the hormesis cosmetics including radioactive sources were analyzed using INAA, PGAA and NAA with multiple gamma-ray detection (NAAMG). Nineteen elements were analyzed quantitatively in hormesis cosmetics by INAA, PGAA and NAAMG and 16 elements were detected qualitatively by SEM-EPMA. (author)

  7. Elements of social security

    DEFF Research Database (Denmark)

    Hansen, Hans

    Elements of Social Security is a comparative study of important elements of the social security systems in Denmark (DK), Sweden (S), Finland (FIN), Austria (A), Germany (D), the Netherlands (NL), Great Britain (GB) and Canada (CAN). It should be emphasized that Germany is the former West Germany...... (Alte Länder). This is the 9th and last edition of the publication,covering income levels and rules for social security and personal taxation for 1999. Basis for the projections to 1999 income levels is the 1998 data (in some cases 1999 data)for OECD's Taxing Wages as reported by national experts....

  8. Bibliography on transuranium elements

    International Nuclear Information System (INIS)

    Sood, D.D.

    1991-01-01

    A selective bibliography of prominent publications on transuranium elements is compiled. Heading papers, symposia proceedings and the textbooks are included in the bibliography. The bibliography is arranged under the headings: (1)Books, Symposia Proceedings, Reviews etc., (2)Discovery, (3)Weighable Isolation, (4)Metal Preparation, (5)Nuclear Properties, (6)Plutonium as Reactor Fuel, (7)Fuel Reprocessing, (8)Solid State Chemistry, Thermochemistry and Spectroscopy, (9)Radiation Safety, (10)Applications, and (11)Some Typical Indian Papers. Total number of references cited are 298. The bibliography, though selective, will serve as a starting point for comprehensive literature search on transuranium elements. (author)

  9. Finite elements and approximation

    CERN Document Server

    Zienkiewicz, O C

    2006-01-01

    A powerful tool for the approximate solution of differential equations, the finite element is extensively used in industry and research. This book offers students of engineering and physics a comprehensive view of the principles involved, with numerous illustrative examples and exercises.Starting with continuum boundary value problems and the need for numerical discretization, the text examines finite difference methods, weighted residual methods in the context of continuous trial functions, and piecewise defined trial functions and the finite element method. Additional topics include higher o

  10. Elements of Social Security

    DEFF Research Database (Denmark)

    Hansen, Hans

    Elements of Social Security contains an overview of important benefit schemes in Denmark, Sweden, Finland, Austria, Germany, the Netherlands, Great Britain and Canada. The schemes are categorized according to common sets of criteria and compared. Stylized cases illustrate the impact on disposable...

  11. Elements of Social Security

    DEFF Research Database (Denmark)

    Hansen, Hans

    Elements of Social Security contains an overview of important benefit schemes in Denmark, Sweden, Finland, Germany, the Netherlands, Great Britain and Canada. The schemes are categorized according to common sets of criteria and compared. Stylized cases illustrate the impact on disposable income...

  12. Elements of Social Security

    DEFF Research Database (Denmark)

    Hansen, Hans

    Elements of Social Security contains an overview of important benefit schemes in Denmark, Sweden, Finland, Germany, Great Britain, the Netherlands and Canada. The schemes are categorized according to common sets of criteria and compared. Stylized cases illustrate the impact on disposable income...

  13. Water, the intangible element

    NARCIS (Netherlands)

    Schotting, R.J.

    2009-01-01

    Water is the key to life. No living creature can survive without water. Too much water or polluted water are serious threats to mankind. Managing this intangible element is complex, not only in wet deltaic regions but also in the (semi-)arid regions of the world. Combined efforts of the

  14. Movies and Literary Elements.

    Science.gov (United States)

    Keller, Rodney D.

    1987-01-01

    Recommends using movie clips to stimulate students' interest in reading a novel as well as to teach elements of fiction such as plot, character, setting, symbol, irony, and theme. Describes each clip and provides study questions. Includes a listing of movies made from books. (NH)

  15. Elements of Architecture

    DEFF Research Database (Denmark)

    Elements of Architecture explores new ways of engaging architecture in archaeology. It conceives of architecture both as the physical evidence of past societies and as existing beyond the physical environment, considering how people in the past have not just dwelled in buildings but have existed...

  16. Inside finite elements

    CERN Document Server

    Weiser, Martin

    2016-01-01

    All relevant implementation aspects of finite element methods are discussed in this book. The focus is on algorithms and data structures as well as on their concrete implementation. Theory is covered as far as it gives insight into the construction of algorithms. Throughout the exercises a complete FE-solver for scalar 2D problems will be implemented in Matlab/Octave.

  17. Plants' essential chemical elements

    Science.gov (United States)

    Kevin T. Smith

    2007-01-01

    Every garden center and hardware store sells fertilizer guaranteed to "feed" plants. In a strict sense, we can't feed plants. Food contains an energy source. Green plants capture solar energy and make their own food through photosynthesis! Photosynthesis and other metabolic processes require chemical elements in appropriate doses for plants to survive...

  18. Elements of relativity theory

    International Nuclear Information System (INIS)

    Lawden, D.F.

    1985-01-01

    The book on elements of relativity theory is intended for final year school students or as an early university course in mathematical physics. Special principle of relativity, lorentz transformation, velocity transformations, relativistic mechanics, and general theory of relativity, are all discussed. (U.K.)

  19. Photovoltaic radiation detector element

    International Nuclear Information System (INIS)

    Agouridis, D.C.

    1980-01-01

    A radiation detector element is formed of a body of semiconductor material, a coating on the body which forms a photovoltaic junction therewith, and a current collector consisting of narrow metallic strips, the aforesaid coating having an opening therein in the edge of which closely approaches but is spaced from the current collector strips

  20. Determination of the metal distribution in tooth fillings in real teeth based on element sensitive X-ray tomography

    International Nuclear Information System (INIS)

    Masschaele, B.; Mondelaers, W.; Cauwels, P.; Jolie, J.; Baechler, S.; Materna, T.

    2000-01-01

    Since a couple of centuries people are using metal tooth-fillings in order to protect their teeth. In the beginning of the 19th century the amalgam or silver fillings were introduced for to first time. Nowadays, dentists mostly use amalgam. These fillings are a mixture of silver, tin and mercury. The mercury which is abundant, about 50%, is dangerous for any living organism. Mercury has a particular affinity for the brain tissue but is also accumulated in the liver, kidneys, lungs, gastrointestinal track and jawbone. Mercury Basely crosses the placenta and is gathered in the heart, pituitary gland and liver of the fetus. It is been proven that the mercury vaporises and enter enters the body via the lungs. Since a couple of years we apply the element sensitive X-ray tomography technique on heavy elements like uranium or lead. By scanning teeth using photons having two different energies, one just below and one just above the K-edge of the element under investigation, the tomography becomes element sensitive. The experiment has been done at the ESRF, beam line ID15A, with a very intense tunable monochromatic high energy X-ray beam. We made tomographies of different teeth with 20 μm image resolution. The slices were 20 μm apart. The results after reconstruction are three dimensional mercury maps which can tell us something about the possibility of mercury diffusion into the roots of the tooth. From there the mercury could enter the blood stream and end up in the organs. (author)

  1. Incorporation of Trace Elements in Ancient and Modern Human Bone: An X-Ray Absorption Spectroscopy Study

    Science.gov (United States)

    Pingitore, N. E.; Cruz-Jimenez, G.; Price, T. D.

    2001-12-01

    X-ray absorption spectroscopy (XAS) affords the opportunity to probe the atomic environment of trace elements in human bone. We are using XAS to investigate the mode(s) of incorporation of Sr, Zn, Pb, and Ba in both modern and ancient (and thus possibly altered) human and animal bone. Because burial and diagenesis may add trace elements to bone, we performed XAS analysis on samples of pristine contemporary and ancient, buried human and animal bone. We assume that deposition of these elements during burial occurs by processes distinct from those in vivo, and this will be reflected in their atomic environments. Archaeologists measure strontium in human and animal bone as a guide to diet. Carnivores show lower Sr/Ca ratios than their herbivore prey due to discrimination against Sr relative to Ca up the food chain. In an initial sample suite no difference was observed between modern and buried bone. Analysis of additional buried samples, using a more sensitive detector, revealed significant differences in the distance to the second and third neighbors of the Sr in some of the buried samples. Distances to the first neighbor, oxygen, were similar in all samples. Zinc is also used in paleo-diet studies. Initial x-ray absorption spectroscopy of a limited suite of bones did not reveal any differences between modern and buried samples. This may reflect the limited number of samples examined or the low levels of Zn in typical aqueous solutions in soils. Signals from barium and lead were too low to record useful XAS spectra. Additional samples will be studied for Zn, Ba, and Pb. We conducted our XAS experiments on beam lines 4-1 and 4-3 at the Stanford Synchrotron Radiation Laboratory. Data were collected in the fluorescence mode, using a Lytle detector and appropriate filter, and a solid state, 13-element Ge-detector.

  2. Multiple-Ring Digital Communication Network

    Science.gov (United States)

    Kirkham, Harold

    1992-01-01

    Optical-fiber digital communication network to support data-acquisition and control functions of electric-power-distribution networks. Optical-fiber links of communication network follow power-distribution routes. Since fiber crosses open power switches, communication network includes multiple interconnected loops with occasional spurs. At each intersection node is needed. Nodes of communication network include power-distribution substations and power-controlling units. In addition to serving data acquisition and control functions, each node acts as repeater, passing on messages to next node(s). Multiple-ring communication network operates on new AbNET protocol and features fiber-optic communication.

  3. Repetitive Elements in Mycoplasma hyopneumoniae Transcriptional Regulation.

    Directory of Open Access Journals (Sweden)

    Amanda Malvessi Cattani

    Full Text Available Transcriptional regulation, a multiple-step process, is still poorly understood in the important pig pathogen Mycoplasma hyopneumoniae. Basic motifs like promoters and terminators have already been described, but no other cis-regulatory elements have been found. DNA repeat sequences have been shown to be an interesting potential source of cis-regulatory elements. In this work, a genome-wide search for tandem and palindromic repetitive elements was performed in the intergenic regions of all coding sequences from M. hyopneumoniae strain 7448. Computational analysis demonstrated the presence of 144 tandem repeats and 1,171 palindromic elements. The DNA repeat sequences were distributed within the 5' upstream regions of 86% of transcriptional units of M. hyopneumoniae strain 7448. Comparative analysis between distinct repetitive sequences found in related mycoplasma genomes demonstrated different percentages of conservation among pathogenic and nonpathogenic strains. qPCR assays revealed differential expression among genes showing variable numbers of repetitive elements. In addition, repeats found in 206 genes already described to be differentially regulated under different culture conditions of M. hyopneumoniae strain 232 showed almost 80% conservation in relation to M. hyopneumoniae strain 7448 repeats. Altogether, these findings suggest a potential regulatory role of tandem and palindromic DNA repeats in the M. hyopneumoniae transcriptional profile.

  4. Repetitive Elements in Mycoplasma hyopneumoniae Transcriptional Regulation.

    Science.gov (United States)

    Cattani, Amanda Malvessi; Siqueira, Franciele Maboni; Guedes, Rafael Lucas Muniz; Schrank, Irene Silveira

    2016-01-01

    Transcriptional regulation, a multiple-step process, is still poorly understood in the important pig pathogen Mycoplasma hyopneumoniae. Basic motifs like promoters and terminators have already been described, but no other cis-regulatory elements have been found. DNA repeat sequences have been shown to be an interesting potential source of cis-regulatory elements. In this work, a genome-wide search for tandem and palindromic repetitive elements was performed in the intergenic regions of all coding sequences from M. hyopneumoniae strain 7448. Computational analysis demonstrated the presence of 144 tandem repeats and 1,171 palindromic elements. The DNA repeat sequences were distributed within the 5' upstream regions of 86% of transcriptional units of M. hyopneumoniae strain 7448. Comparative analysis between distinct repetitive sequences found in related mycoplasma genomes demonstrated different percentages of conservation among pathogenic and nonpathogenic strains. qPCR assays revealed differential expression among genes showing variable numbers of repetitive elements. In addition, repeats found in 206 genes already described to be differentially regulated under different culture conditions of M. hyopneumoniae strain 232 showed almost 80% conservation in relation to M. hyopneumoniae strain 7448 repeats. Altogether, these findings suggest a potential regulatory role of tandem and palindromic DNA repeats in the M. hyopneumoniae transcriptional profile.

  5. Writing analytic element programs in Python.

    Science.gov (United States)

    Bakker, Mark; Kelson, Victor A

    2009-01-01

    The analytic element method is a mesh-free approach for modeling ground water flow at both the local and the regional scale. With the advent of the Python object-oriented programming language, it has become relatively easy to write analytic element programs. In this article, an introduction is given of the basic principles of the analytic element method and of the Python programming language. A simple, yet flexible, object-oriented design is presented for analytic element codes using multiple inheritance. New types of analytic elements may be added without the need for any changes in the existing part of the code. The presented code may be used to model flow to wells (with either a specified discharge or drawdown) and streams (with a specified head). The code may be extended by any hydrogeologist with a healthy appetite for writing computer code to solve more complicated ground water flow problems. Copyright © 2009 The Author(s). Journal Compilation © 2009 National Ground Water Association.

  6. Element-topology-independent preconditioners for parallel finite element computations

    Science.gov (United States)

    Park, K. C.; Alexander, Scott

    1992-01-01

    A family of preconditioners for the solution of finite element equations are presented, which are element-topology independent and thus can be applicable to element order-free parallel computations. A key feature of the present preconditioners is the repeated use of element connectivity matrices and their left and right inverses. The properties and performance of the present preconditioners are demonstrated via beam and two-dimensional finite element matrices for implicit time integration computations.

  7. Measurement of Hadron Multiplicities in Deep Inelastic Muon-Nucleon Scattering

    CERN Document Server

    du Fresne von Hohenesche, Nicolas

    2016-06-02

    In deep-inelastic muon-nucleon scattering, a single quark can be ejected out of the nucleon by the absorption of a high-energy photon. Such a free isolated quark has never been observed in nature. In quantum chromodynamics (QCD), coloured objects, such as a single quark, create additional quark anti-quark pairs out of the colour field and the final state comprises a jet of hadrons. The hadronisation process can be described by fragmentation functions D_q^h, the probability that a quark with the flavour q turns into a hadron of the type h. Similar to the parton distribution function, the fragmentation functions are fundamental, universal and process-independent quantities. The fragmentation functions are measured with the COM- PASS spectrometer in muon-nucleon scattering. The observables are the hadron multiplicities M_h. The COMPASS experiment consists of a two-stage magnetic spectrometer located at the M2 beam line of the Super Proton Synchrotron at CERN and uses a polarised muon beam on a nuclear fixed targ...

  8. Four-terminal circuit element with photonic core

    Science.gov (United States)

    Sampayan, Stephen

    2017-08-29

    A four-terminal circuit element is described that includes a photonic core inside of the circuit element that uses a wide bandgap semiconductor material that exhibits photoconductivity and allows current flow through the material in response to the light that is incident on the wide bandgap material. The four-terminal circuit element can be configured based on various hardware structures using a single piece or multiple pieces or layers of a wide bandgap semiconductor material to achieve various designed electrical properties such as high switching voltages by using the photoconductive feature beyond the breakdown voltages of semiconductor devices or circuits operated based on electrical bias or control designs. The photonic core aspect of the four-terminal circuit element provides unique features that enable versatile circuit applications to either replace the semiconductor transistor-based circuit elements or semiconductor diode-based circuit elements.

  9. An efficient finite element solution for gear dynamics

    International Nuclear Information System (INIS)

    Cooley, C G; Parker, R G; Vijayakar, S M

    2010-01-01

    A finite element formulation for the dynamic response of gear pairs is proposed. Following an established approach in lumped parameter gear dynamic models, the static solution is used as the excitation in a frequency domain solution of the finite element vibration model. The nonlinear finite element/contact mechanics formulation provides accurate calculation of the static solution and average mesh stiffness that are used in the dynamic simulation. The frequency domain finite element calculation of dynamic response compares well with numerically integrated (time domain) finite element dynamic results and previously published experimental results. Simulation time with the proposed formulation is two orders of magnitude lower than numerically integrated dynamic results. This formulation admits system level dynamic gearbox response, which may include multiple gear meshes, flexible shafts, rolling element bearings, housing structures, and other deformable components.

  10. Archaeal extrachromosomal genetic elements

    DEFF Research Database (Denmark)

    Wang, Haina; Peng, Nan; Shah, Shiraz Ali

    2015-01-01

    SUMMARY: Research on archaeal extrachromosomal genetic elements (ECEs) has progressed rapidly in the past decade. To date, over 60 archaeal viruses and 60 plasmids have been isolated. These archaeal viruses exhibit an exceptional diversity in morphology, with a wide array of shapes, such as spind......SUMMARY: Research on archaeal extrachromosomal genetic elements (ECEs) has progressed rapidly in the past decade. To date, over 60 archaeal viruses and 60 plasmids have been isolated. These archaeal viruses exhibit an exceptional diversity in morphology, with a wide array of shapes...... on archaeal ECEs has just started to unravel the molecular biology of these genetic entities and their interactions with archaeal hosts, it is expected to accelerate in the next decade....

  11. Nuclear fuel element

    Energy Technology Data Exchange (ETDEWEB)

    Armijo, J S; Coffing, L F

    1979-04-05

    The fuel element with circular cross-section for BWR and PWR consists of a core surrounded by a compound jacket container where there is a gap between the core and jacket during operation in the reactor. The core consists of U, Pu, Th compounds and mixtures of these. The compound jacket consists of zircaloy 2 or 4. In order to for example prevent the corrosion of the compound jacket, its inner surface has a metal barrier with smaller neutron absorbers than the jacket material in the form of a zirconium sponge. The zirconium of this metal barrier has impurities of various elements in the order of magnitude of 1000 to 5000 ppm. The oxygen content is in the range of 200 to 1200 ppm and the thickness of the metal barrier is 1-30% of the thickness of the jacket.

  12. Nuclear reactor fuel element

    International Nuclear Information System (INIS)

    D'Eye, R.W.M.; Shennan, J.V.; Ford, L.H.

    1977-01-01

    Fuel element with particles from ceramic fissionable material (e.g. uranium carbide), each one being coated with pyrolitically deposited carbon and all of them being connected at their points of contact by means of an individual crossbar. The crossbar consists of silicon carbide produced by reaction of silicon metal powder with the carbon under the influence of heat. Previously the silicon metal powder together with the particles was kneaded in a solvent and a binder (e.g. epoxy resin in methyl ethyl ketone plus setting agent) to from a pulp. The reaction temperature lies at 1750 0 C. The reaction itself may take place in a nitrogen atmosphere. There will be produced a fuel element with a high overall thermal conductivity. (DG) [de

  13. Elements of quantum optics

    CERN Document Server

    Meystre, Pierre

    2007-01-01

    Elements of Quantum Optics gives a self-contained and broad coverage of the basic elements necessary to understand and carry out research in laser physics and quantum optics, including a review of basic quantum mechanics and pedagogical introductions to system-reservoir interactions and to second quantization. The text reveals the close connection between many seemingly unrelated topics, such as probe absorption, four-wave mixing, optical instabilities, resonance fluorescence and squeezing. It also comprises discussions of cavity quantum electrodynamics and atom optics. The 4th edition includes a new chapter on quantum entanglement and quantum information, as well as added discussions of the quantum beam splitter, electromagnetically induced transparency, slow light, and the input-output formalism needed to understand many problems in quantum optics. It also provides an expanded treatment of the minimum-coupling Hamiltonian and a simple derivation of the Gross-Pitaevskii equation, an important gateway to rese...

  14. Periodic table of elements

    International Nuclear Information System (INIS)

    Fluck, E.; Heumann, K.G.

    1985-01-01

    Following a recommendation by the International Union for Pure and Applied Chemistry (IUPAC), the groups of the periodic table shall be numbered from 1 to 18, instead of I to VIII as before. The recommendations has been approved of by the Committee on Nomenclature of the American Chemical Society. The new system abandons the distinction between main groups (a) and auxiliary groups (b), which in the past frequently has been the reason for misunderstandings between European and American chemists, due to different handling. The publishing house VCH Verlagsgesellschaft recently produced a new periodic table that shows the old and the new numbering system together at a glance, so that chemists will have time to get familiar with the new system. In addition the new periodic table represents an extensive data compilation arranged by elements. The front page lists the chemical properties of elements, the back page their physical properties. (orig./EF) [de

  15. Nuclear fuel elements

    International Nuclear Information System (INIS)

    Kawada, Toshiyuki; Hirayama, Satoshi; Yoneya, Katsutoshi.

    1980-01-01

    Purpose: To enable load-depending operation as well as moderation for the restriction of operation conditions in the present nuclear reactors, by specifying the essential ingredients and the total weight of the additives to UO 2 fuel substances. Constitution: Two or more additives selected from Al 2 O 3 , B 2 O, CaO, MgO, SiO 2 , Na 2 O and P 2 O 5 are added by the total weight of 2 - 5% to fuel substances consisting of UO 2 or a mixture of UO 2 and PuO 2 . When the mixture is sintered, the strength of the fuel elements is decreased and the fuel-cladding interactions due to the difference in the heat expansion coefficients between the ceramic fuel elements and the metal claddings are decreased to a substantially harmless degree. (Horiuchi, T.)

  16. Nuclear fuel elements

    International Nuclear Information System (INIS)

    Nakai, Keiichi

    1983-01-01

    Purpose: To decrease the tensile stresses resulted in a fuel can as well as prevent decladding of fuel pellets into the bore holes by decreasing the inner pressure within the nuclear fuel element. Constitution: A fuel can is filled with hollow fuel pellets, inserted with a spring for retaining the hollow fuel pellets with an appropriate force and, thereafter, closely sealed at the both ends with end plugs. A cylindrical body is disposed into the bore holes of the hollow fuel pellets. Since initial sealing gases and/or gaseous nuclear fission products can thus be excluded from the bore holes where the temperature is at the highest level, the inner pressure of the nuclear fuel element can be reduced to decrease the tensile strength resulted to the fuel can. Furthermore, decladding of fuel pellets into the bore holes can be prevented. (Moriyama, K.)

  17. Generalized internal multiple imaging

    KAUST Repository

    Zuberi, Mohammad Akbar Hosain

    2014-12-04

    Various examples are provided for generalized internal multiple imaging (GIMI). In one example, among others, a method includes generating a higher order internal multiple image using a background Green\\'s function and rendering the higher order internal multiple image for presentation. In another example, a system includes a computing device and a generalized internal multiple imaging (GIMI) application executable in the computing device. The GIMI application includes logic that generates a higher order internal multiple image using a background Green\\'s function and logic that renders the higher order internal multiple image for display on a display device. In another example, a non-transitory computer readable medium has a program executable by processing circuitry that generates a higher order internal multiple image using a background Green\\'s function and renders the higher order internal multiple image for display on a display device.

  18. MultipleColposcopyJCO

    Science.gov (United States)

    Performing multiple biopsies during a procedure known as colposcopy—visual inspection of the cervix—is more effective than performing only a single biopsy of the worst-appearing area for detecting cervical cancer precursors. This multiple biopsy approach

  19. Salmonella Infections - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Salmonella Infections URL of this page: https://medlineplus.gov/ ... V W XYZ List of All Topics All Salmonella Infections - Multiple Languages To use the sharing features ...

  20. Health Literacy - Multiple Languages

    Science.gov (United States)

    ... Here: Home → Multiple Languages → All Health Topics → Health Literacy URL of this page: https://medlineplus.gov/languages/ ... W XYZ List of All Topics All Health Literacy - Multiple Languages To use the sharing features on ...

  1. Cosmetic Dentistry - Multiple Languages

    Science.gov (United States)

    ... Here: Home → Multiple Languages → All Health Topics → Cosmetic Dentistry URL of this page: https://medlineplus.gov/languages/ ... W XYZ List of All Topics All Cosmetic Dentistry - Multiple Languages To use the sharing features on ...

  2. Atrial Fibrillation - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Atrial Fibrillation URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Atrial Fibrillation - Multiple Languages To use the sharing features on ...

  3. Zika Virus - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Zika Virus URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Zika Virus - Multiple Languages To use the sharing features on ...

  4. Elder Abuse - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Elder Abuse URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Elder Abuse - Multiple Languages To use the sharing features on ...

  5. Herbal Medicine - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Herbal Medicine URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Herbal Medicine - Multiple Languages To use the sharing features on ...

  6. Generalized internal multiple imaging

    KAUST Repository

    Zuberi, Mohammad Akbar Hosain; Alkhalifah, Tariq

    2014-01-01

    Various examples are provided for generalized internal multiple imaging (GIMI). In one example, among others, a method includes generating a higher order internal multiple image using a background Green's function and rendering the higher order internal multiple image for presentation. In another example, a system includes a computing device and a generalized internal multiple imaging (GIMI) application executable in the computing device. The GIMI application includes logic that generates a higher order internal multiple image using a background Green's function and logic that renders the higher order internal multiple image for display on a display device. In another example, a non-transitory computer readable medium has a program executable by processing circuitry that generates a higher order internal multiple image using a background Green's function and renders the higher order internal multiple image for display on a display device.

  7. Domestic Violence - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Domestic Violence URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Domestic Violence - Multiple Languages To use the sharing features on ...

  8. Multiple Primary Tumors

    African Journals Online (AJOL)

    2017-12-05

    Dec 5, 2017 ... Multiple primary tumors occur in clinical practice causing diagnostic dilemma. It is not very .... was estrogen receptor negative, progesterone receptor negative, and ... cervical, ovarian, and urinary bladder cancers. Multiple.

  9. Diabetic Foot - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Diabetic Foot URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Diabetic Foot - Multiple Languages To use the sharing features on ...

  10. Child Abuse - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Child Abuse URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Child Abuse - Multiple Languages To use the sharing features on ...

  11. Fatigue and Multiple Sclerosis

    Science.gov (United States)

    ... to navigation Skip to content Menu Navigation National Multiple Sclerosis Society Sign In In Your Area Donate Donate ... of MS What Causes MS? Who Gets MS? Multiple Sclerosis FAQs Types of MS Related Conditions Symptoms & Diagnosis ...

  12. Rotavirus Infections - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Rotavirus Infections URL of this page: https://medlineplus.gov/ ... V W XYZ List of All Topics All Rotavirus Infections - Multiple Languages To use the sharing features ...

  13. Nuclear fuel elements

    International Nuclear Information System (INIS)

    Ainsworth, K.F.

    1979-01-01

    A nuclear fuel element is described having a cluster of nuclear fuel pins supported in parallel, spaced apart relationship by transverse cellular braces within coaxial, inner and outer sleeves, the inner sleeve being in at least two separate axial lengths, each of the transverse braces having a peripheral portion which is clamped peripherally between the ends of the axial lengths of the inner sleeve. (author)

  14. Sensor for ionizable elements

    International Nuclear Information System (INIS)

    Berkey, E.; Reed, W.A. III; Hickam, W.M.

    1977-01-01

    Sensor to detect thermally ionizable elements or molucules in air, water vapour or oxygen or to be used as alkali leak detector in vacuum systems, e.g. in the pipe system of a liquid-metal cooled FBR. The sensor consists of an filament made of thorium-containing iridium as cathode with a temperature upto 1000 0 C and an anode sheet of molybdenum, nickel or stainless steal. (ORU) [de

  15. Nuclear reactor fuel elements

    International Nuclear Information System (INIS)

    Butterfield, C.E.; Waite, E.

    1982-01-01

    A nuclear reactor fuel element comprising a column of vibration compacted fuel which is retained in consolidated condition by a thimble shaped plug. The plug is wedged into gripping engagement with the wall of the sheath by a wedge. The wedge material has a lower coefficient of expansion than the sheath material so that at reactor operating temperature the retainer can relax sufficient to accommodate thermal expansion of the column of fuel. (author)

  16. OXIDATION OF TRANSURANIC ELEMENTS

    Science.gov (United States)

    Moore, R.L.

    1959-02-17

    A method is reported for oxidizing neptunium or plutonium in the presence of cerous values without also oxidizing the cerous values. The method consists in treating an aqueous 1N nitric acid solution, containing such cerous values together with the trivalent transuranic elements, with a quantity of hydrogen peroxide stoichiometrically sufficient to oxidize the transuranic values to the hexavalent state, and digesting the solution at room temperature.

  17. Transportation of radioactive elements

    International Nuclear Information System (INIS)

    Thubert, Francis; Rentien, Guy; Jacquet, Michel

    1981-01-01

    The production and marketing of artificial radioactive elements engaged in by the 'Office des Rayonnements Ionisants' requires the use of specially designed packagings and assorted means of transport. The authors begin by describing the different kinds of products involved and the forms of packagings needed, and go on to discuss the various means of transport used, underlining the fact that, in terms of number and gravity, the incidents that have occurred to date have indeed been few and far between [fr

  18. Vented nuclear fuel element

    International Nuclear Information System (INIS)

    Oguma, M.; Hirose, Y.

    1976-01-01

    A description is given of a vented nuclear fuel element having a plenum for accumulation of fission product gases and plug means for delaying the release of the fission product gases from the plenum, the plug means comprising a first porous body wettable with a liquid metal and a second porous body non-wettable with the liquid metal, the first porous body being impregnated with the liquid metal and in contact with the liquid metal

  19. Helium the disappearing element

    CERN Document Server

    Sears, Wheeler M

    2015-01-01

    The subject of the book is helium, the element, and its use in myriad applications including MRI machines, particle accelerators, space telescopes, and of course balloons and blimps. It was at the birth of our Universe, or the Big Bang, where the majority of cosmic helium was created; and stellar helium production continues. Although helium is the second most abundant element in the Universe, it is actually quite rare here on Earth and only exists because of radioactive elements deep within the Earth. This book includes a detailed history of the discovery of helium, of the commercial industry built around it, how the helium we actually encounter is produced within the Earth, and the state of the helium industry today. The gas that most people associate with birthday party balloons is running out. “Who cares?” you might ask. Well, without helium, MRI machines could not function, rockets could not go into space, particle accelerators such as those used by CERN could not operate, fiber optic cables would not...

  20. Elements of quantum information

    International Nuclear Information System (INIS)

    Schleich, W.P.

    2007-01-01

    Elements of Quantum Information introduces the reader to the fascinating field of quantum information processing, which lives on the interface between computer science, physics, mathematics, and engineering. This interdisciplinary branch of science thrives on the use of quantum mechanics as a resource for high potential modern applications. With its wide coverage of experiments, applications, and specialized topics - all written by renowned experts - Elements of Quantum Information provides and indispensable, up-to-date account of the state of the art of this rapidly advancing field and takes the reader straight up to the frontiers of current research. The articles have first appeared as a special issue of the journal 'Fortschritte der Physik / Progress of Physics'. Since then, they have been carefully updated. The book will be an inspiring source of information and insight for anyone researching and specializing in experiments and theory of quantum information. Topics addressed in Elements of Quantum Information include - Cavity Quantum Electrodynamics - Segmented Paul Traps - Cold Atoms and Bose-Einstein Condensates in Microtraps, Optical Lattices, and on Atom Chips - Rydberg Gases - Factorization of Numbers with Physical Systems - Entanglement of Continuous Variables - NMR and Solid State Quantum Computation - Quantum Algorithms and Quantum Machines - Complexity Theory - Quantum Crytography. (orig.)

  1. Using Finite Element Method

    Directory of Open Access Journals (Sweden)

    M.H.R. Ghoreishy

    2008-02-01

    Full Text Available This research work is devoted to the footprint analysis of a steel-belted radial tyre (185/65R14 under vertical static load using finite element method. Two models have been developed in which in the first model the tread patterns were replaced by simple ribs while the second model was consisted of details of the tread blocks. Linear elastic and hyper elastic (Arruda-Boyce material models were selected to describe the mechanical behavior of the reinforcing and rubbery parts, respectively. The above two finite element models of the tyre were analyzed under inflation pressure and vertical static loads. The second model (with detailed tread patterns was analyzed with and without friction effect between tread and contact surfaces. In every stage of the analysis, the results were compared with the experimental data to confirm the accuracy and applicability of the model. Results showed that neglecting the tread pattern design not only reduces the computational cost and effort but also the differences between computed deformations do not show significant changes. However, more complicated variables such as shape and area of the footprint zone and contact pressure are affected considerably by the finite element model selected for the tread blocks. In addition, inclusion of friction even in static state changes these variables significantly.

  2. Study of Superheavy Elements

    International Nuclear Information System (INIS)

    Hofmann, Sigurd

    2007-01-01

    The nuclear shell model predicts that the next doubly magic shell-closure beyond 208 Pb is at a proton number Z = 114, 120, or 126 and at a neutron number N = 172 or 184. The outstanding aim of experimental investigations is the exploration of this region of spherical 'SuperHeavy Elements' (SHEs). Experimental methods are described, which allowed for the identification of elements produced on a cross-section level of about 1 pb. The decay data reveal that for the heaviest elements, the dominant decay mode is alpha emission, not fission. Decay properties as well as reaction cross-sections are compared with results of theoretical investigations. Finally, plans are presented for the further development of the experimental set-up and the application of new techniques, as for instance the precise mass measurement of the produced nuclei using ion traps. At increased sensitivity, the detailed exploration of the region of spherical SHEs will start, after first steps on the island were made in recent years. (Author)

  3. Probabilistic finite elements

    Science.gov (United States)

    Belytschko, Ted; Wing, Kam Liu

    1987-01-01

    In the Probabilistic Finite Element Method (PFEM), finite element methods have been efficiently combined with second-order perturbation techniques to provide an effective method for informing the designer of the range of response which is likely in a given problem. The designer must provide as input the statistical character of the input variables, such as yield strength, load magnitude, and Young's modulus, by specifying their mean values and their variances. The output then consists of the mean response and the variance in the response. Thus the designer is given a much broader picture of the predicted performance than with simply a single response curve. These methods are applicable to a wide class of problems, provided that the scale of randomness is not too large and the probabilistic density functions possess decaying tails. By incorporating the computational techniques we have developed in the past 3 years for efficiency, the probabilistic finite element methods are capable of handling large systems with many sources of uncertainties. Sample results for an elastic-plastic ten-bar structure and an elastic-plastic plane continuum with a circular hole subject to cyclic loadings with the yield stress on the random field are given.

  4. New functionalities in abundant element oxides: ubiquitous element strategy

    International Nuclear Information System (INIS)

    Hosono, Hideo; Hayashi, Katsuro; Kamiya, Toshio; Atou, Toshiyuki; Susaki, Tomofumi

    2011-01-01

    While most ceramics are composed of ubiquitous elements (the ten most abundant elements within the Earth's crust), many advanced materials are based on rare elements. A 'rare-element crisis' is approaching owing to the imbalance between the limited supply of rare elements and the increasing demand. Therefore, we propose a 'ubiquitous element strategy' for materials research, which aims to apply abundant elements in a variety of innovative applications. Creation of innovative oxide materials and devices based on conventional ceramics is one specific challenge. This review describes the concept of ubiquitous element strategy and gives some highlights of our recent research on the synthesis of electronic, thermionic and structural materials using ubiquitous elements. (topical review)

  5. Confocal (micro)-XRF for 3D analysis of elements distribution in hot environmental particles

    International Nuclear Information System (INIS)

    Bielewski, M.; Eriksson, M.; Himbert, J.; Simon, R.; Betti, M.; Hamilton, T.F.

    2007-01-01

    Studies on the fate and transport of radioactive contaminates in the environment are often constrained by a lack of knowledge on the elemental distribution and general behavior of particulate bound radionuclides contained in hot particles. A number of hot particles were previously isolated from soil samples collected at former U.S. nuclear test sites in the Marshall Islands and characterized using non-destructive techniques [1]. The present investigation at HASYLAB is a part of larger research program at ITU regarding the characterization of environmental radioactive particles different locations and source-terms. Radioactive particles in the environment are formed under a number of different release scenarios and, as such, their physicochemical properties may provide a basis for identifying source-term specific contamination regimes. Consequently, studies on hot particles are not only important in terms of studying the elemental composition and geochemical behavior of hot particles but may also lead to advances in assessing the long-term impacts of radioactive contamination on the environment. Six particles isolated from soil samples collected at the Marshall Islands were studied. The element distribution in the particles was determined by confocal (micro)-XRF analysis using the ANKA FLUO beam line. The CRL (compound refractive lens) was used to focus the exciting beam and the polycapillary half lens to collimate the detector. The dimensions of confocal spot were measured by 'knife edge scanning' method with thin gold structure placed at Si wafer. The values of 3.1 x 1.4 x 18.4 (micro)m were achieved if defined as FWHMs of measured L?intensity profiles and when the19.1 keV exciting radiation was used. The collected XRF spectra were analyzed offline with AXIL [2] software to obtain net intensities of element characteristic lines.Further data processing and reconstruction of element distribution was done with the software 'R' [3] dedicated for statistical

  6. Neutron Multiplicity Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Frame, Katherine Chiyoko [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-06-28

    Neutron multiplicity measurements are widely used for nondestructive assay (NDA) of special nuclear material (SNM). When combined with isotopic composition information, neutron multiplicity analysis can be used to estimate the spontaneous fission rate and leakage multiplication of SNM. When combined with isotopic information, the total mass of fissile material can also be determined. This presentation provides an overview of this technique.

  7. Use of a synchrotron radiation x-ray microprobe for elemental analysis at the National Synchrotron Light Source

    International Nuclear Information System (INIS)

    Gordon, B.M.

    1980-01-01

    The National Synchrotron Light Source (NSLS) is a facility consisting of a 700 MeV and a 2.5 GeV electron storage ring and dedicated to providing synchrotron radiation in the energy range from the vacuum ultraviolet to high energy x rays. Some of the properties of synchrotron radiation that contribute to its usefulness for x-ray fluorescence are: a continuous, tunable energy spectrum, strong collimation in the horizontal plane, high polarization in the storage ring plane, and relatively low energy deposition. The highest priority is for the development of an x-ray microprobe beam line capable of trace analysis in the parts per million range with spatial resolution as low as one micrometer. An eventual capability for bulk sample analysis is also planned with sensitivities in the more favorable cases beings low as 50 parts per billion in dry biological tissue. The microprobe technique has application to a variety of fields including the geological, medical, materials and environmental sciences. Examples of investigations include multielemental trace analysis across grain boundaries for the study of diffusion and cooling processes in geological and materials sciences samples; in leukocytes and other types of individual cells for studying the relationship between trace element concentrations and disease or nutrition; and in individual particles in air pollution samples

  8. The transuranium elements: From neptunium and plutonium to element 112

    International Nuclear Information System (INIS)

    Hoffman, D.C.

    1996-01-01

    Beginning in the 1930's, both chemists and physicists became interested in synthesizing new artificial elements. The first transuranium element, Np, was synthesized in 1940. Over the past six decades, 20 transuranium elements have been produced. A review of the synthesis is given. The procedure of naming the heavy elements is also discussed. It appears feasible to produce elements 113 and 114. With the Berkeley Gas-filled Separator, it should be possible to reach the superheavy elements in the region of the spherical Z=114 shell, but with fewer neutrons than the N=184 spherical shell. 57 refs, 6 figs

  9. Gas sensor with multiple internal reference electrodes and sensing electrodes

    DEFF Research Database (Denmark)

    2016-01-01

    The invention relates to a potentiometric gas sensor, or potentiometric gas detection element, with multiple internal reference electrodes and multiple sensing electrodes for determining the concentrations of gas components in a gaseous mixture. The sensor for gas detection comprises: a solid...

  10. Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes

    DEFF Research Database (Denmark)

    Siepel, Adam; Bejerano, Gill; Pedersen, Jakob Skou

    2005-01-01

    We have conducted a comprehensive search for conserved elements in vertebrate genomes, using genome-wide multiple alignments of five vertebrate species (human, mouse, rat, chicken, and Fugu rubripes). Parallel searches have been performed with multiple alignments of four insect species (three...... species of Drosophila and Anopheles gambiae), two species of Caenorhabditis, and seven species of Saccharomyces. Conserved elements were identified with a computer program called phastCons, which is based on a two-state phylogenetic hidden Markov model (phylo-HMM). PhastCons works by fitting a phylo......-HMM to the data by maximum likelihood, subject to constraints designed to calibrate the model across species groups, and then predicting conserved elements based on this model. The predicted elements cover roughly 3%-8% of the human genome (depending on the details of the calibration procedure) and substantially...

  11. Division algebras with integral elements

    International Nuclear Information System (INIS)

    Koca, M.; Ozdes, N.

    1988-06-01

    Pairing two elements of a given division algebra furnished with a multiplication rule leads to an algebra of higher dimension restricted by 8. This fact is used to obtain the roots of SO(4) and SP(2) from the roots ±1 of SU(2) and the weights ±1/2 of its spinor representation. The root lattice of SO(8) described by 24 integral quaternions are obtained by pairing two sets of roots of SP(2). The root system of F 4 is constructed in terms of 24 integral and 24 ''half-integral'' quaternions. The root lattice of E 8 expressed as 240 integral octonions are obtained by pairing two sets of roots of F 4 . 24 integral quaternions of SO(8) forming a discrete subgroup of SU(2) is shown to be the automorphism group of the root lattices of SO(8), F 4 and E 8 . The roots of maximal subgroups SO(16), E 7 XSU(2), E 6 XSU(3), SU(9) and SU(5)XSU(5) of E 8 are identified with a simple method. Subsets of the discrete subgroup of SU(2) leaving maximal subgroups of E 8 are obtained. Constructions of E 8 root lattice with integral octonions in 7 distinct ways are made. Magic square of integral lattices of Goddard, Nahm, Olive, Ruegg and Schwimmer are derived. Possible physical applications are suggested. (author). 16 refs, 6 figs, 5 tabs

  12. Track reconstruction for the Mu3e experiment based on a novel Multiple Scattering fit

    Directory of Open Access Journals (Sweden)

    Kozlinskiy Alexandr

    2017-01-01

    Full Text Available The Mu3e experiment is designed to search for the lepton flavor violating decay μ+ → e+e+e−. The aim of the experiment is to reach a branching ratio sensitivity of 10−16. In a first phase the experiment will be performed at an existing beam line at the Paul-Scherrer Institute (Switzerland providing 108 muons per second, which will allow to reach a sensitivity of 2 · 10−15. The muons with a momentum of about 28 MeV/c are stopped and decay at rest on a target. The decay products (positrons and electrons with energies below 53MeV are measured by a tracking detector consisting of two double layers of 50 μm thin silicon pixel sensors. The high granularity of the pixel detector with a pixel size of 80 μm × 80 μm allows for a precise track reconstruction in the high multiplicity environment of the Mu3e experiment, reaching 100 tracks per reconstruction frame of 50 ns in the final phase of the experiment. To deal with such high rates and combinatorics, the Mu3e track reconstruction uses a novel fit algorithm that in the simplest case takes into account only the multiple scattering, which allows for a fast online tracking on a GPU based filter farm. An implementation of the 3-dimensional multiple scattering fit based on hit triplets is described. The extension of the fit that takes into account energy losses and pixel size is used for offline track reconstruction. The algorithm and performance of the offline track reconstruction based on a full Geant4 simulation of the Mu3e detector are presented.

  13. Neutron multiplication measurement instrument

    International Nuclear Information System (INIS)

    Nixon, K.V.; Dowdy, E.J.; France, S.W.; Millegan, D.R.; Robba, A.A.

    1983-01-01

    The Advanced Nuclear Technology Group of the Los Alamos National Laboratory is now using intelligent data-acquisition and analysis instrumentation for determining the multiplication of nuclear material. Earlier instrumentation, such as the large NIM-crate systems, depended on house power and required additional computation to determine multiplication or to estimate error. The portable, battery-powered multiplication measurement unit, with advanced computational power, acquires data, calculates multiplication, and completes error analysis automatically. Thus, the multiplication is determined easily and an available error estimate enables the user to judge the significance of results

  14. Elements of social action

    Directory of Open Access Journals (Sweden)

    Marjanović Miloš

    2011-01-01

    Full Text Available Because of the significant analytical advantages, the author prefers social action as initial sociological concept in the relation to social phenomenon. Its basic elements are: actors, subjects and tools, needs and interests, values and norms, positions and roles. Actors set in motion and unify the rest of elements, guide to the magic triangle of sociology (movement, change, order, reaffirm actor paradigm to systemic paradigm. Subjects and tools materialize an action and its overestimate results in technological determinism or (by means of property as institutional appropriation of nature in the (unclassed historical type of society. Needs and interests are the basis of person's motivation and starting point for depth analysis of sociability. The expansion of legitimate interests circle develops techniques of normative regulation. Values and norms guide to institutional-organizational, positions to vertical and roles to horizontal structure. Values give the meaning to the action as well as to human existence, they are orientations of motivate system of personality but also basic aspect of society. As abstractions, values are latent background of norms and they tell to us what to do, and norms how to do something. Norms are specified instructions for suitable behavior Without normative order, not to be possible the satisfying of needs and the conciliation of interests. Riches, power and prestige are components of social position, and legal status is the determination of rights and obligations of the position. Roles are normative expectation of behavior. Toward kinds of sanctions roles are classified. Roles but also other elements of social action are starting point for sociological analysis of legal norms and institutes. On the other side, the observation of legal component of social actions enriches, strengths and precises sociological analysis of them.

  15. Analytical elements of mechanics

    CERN Document Server

    Kane, Thomas R

    2013-01-01

    Analytical Elements of Mechanics, Volume 1, is the first of two volumes intended for use in courses in classical mechanics. The books aim to provide students and teachers with a text consistent in content and format with the author's ideas regarding the subject matter and teaching of mechanics, and to disseminate these ideas. The book opens with a detailed exposition of vector algebra, and no prior knowledge of this subject is required. This is followed by a chapter on the topic of mass centers, which is presented as a logical extension of concepts introduced in connection with centroids. A

  16. Improved nuclear fuel element

    International Nuclear Information System (INIS)

    Klepfer, H.H.

    1974-01-01

    A nuclear fuel element is described which comprises: 1) an elongated clad container, 2) a layer of high lubricity material being disposed in and adjacent to the clad container, 3) a low neutron capture cross section metal liner being disposed in the clad container and adjacent to the layer, 4) a central core of a body of nuclear fuel material disposed in and partially filling the container and forming an internal cavity in the container, 5) an enclosure integrally secured and sealed at each end of the container, and a nuclear fuel material retaining means positioned in the cavity. (author)

  17. Elements of real analysis

    CERN Document Server

    Sprecher, David A

    2010-01-01

    This classic text in introductory analysis delineates and explores the intermediate steps between the basics of calculus and the ultimate stage of mathematics: abstraction and generalization.Since many abstractions and generalizations originate with the real line, the author has made it the unifying theme of the text, constructing the real number system from the point of view of a Cauchy sequence (a step which Dr. Sprecher feels is essential to learn what the real number system is).The material covered in Elements of Real Analysis should be accessible to those who have completed a course in

  18. Nuclear reactor fuel elements

    International Nuclear Information System (INIS)

    Hindle, E. D.

    1984-01-01

    An array of rods is assembled to form a fuel element for a pressurized water reactor, the rods comprising zirconium alloy sheathed nuclear fuel pellets and containing helium. The helium gas pressure is selected for each rod so that it differs substantially from the helium gas pressure in its closest neighbors. In a preferred arrangement the rods are arranged in a square lattice and the helium gas pressure alternates between a relatively high value and a relatively low value so that each rod has as its closest neighbors up to four rods containing helium gas at the other pressure value

  19. Nuclear reactor fuel elements

    Energy Technology Data Exchange (ETDEWEB)

    Hindle, E. D.

    1984-10-16

    An array of rods is assembled to form a fuel element for a pressurized water reactor, the rods comprising zirconium alloy sheathed nuclear fuel pellets and containing helium. The helium gas pressure is selected for each rod so that it differs substantially from the helium gas pressure in its closest neighbors. In a preferred arrangement the rods are arranged in a square lattice and the helium gas pressure alternates between a relatively high value and a relatively low value so that each rod has as its closest neighbors up to four rods containing helium gas at the other pressure value.

  20. Osteoporosis and trace elements

    DEFF Research Database (Denmark)

    Aaseth, J.; Boivin, G.; Andersen, Ole

    2012-01-01

    More than 200 million people are affected by osteoporosis worldwide, as estimated by 2 million annual hip fractures and other debilitating bone fractures (vertebrae compression and Colles' fractures). Osteoporosis is a multi-factorial disease with potential contributions from genetic, endocrine...... in new bone and results in a net gain in bone mass, but may be associated with a tissue of poor quality. Aluminum induces impairment of bone formation. Gallium and cadmium suppresses bone turnover. However, exact involvements of the trace elements in osteoporosis have not yet been fully clarified...