WorldWideScience

Sample records for multichip module development

  1. Multichip module technology development

    International Nuclear Information System (INIS)

    Kapustinsky, J.S.; Boissevain, J.G.; Muck, R.C.; Smith, G.D.; Wong-Swanson, B.G.; Ziock, H.J.

    1997-01-01

    This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). A Multichip Module (MCM) was designed and submitted for fabrication to the Lockheed Martin foundry using a licensed process called High Density Interconnect (HDI). The HDI process uses thin film techniques to create circuit interconnect patterns on multiple layers of dielectric film which are deposited directly on top of unpackaged electronic die. This results in an optimally small package that approaches the area of the bare die themselves. This project tested the capability of the Lockheed Martin foundry to produce, in an HDI process, a complex mixed-mode (analog and digital) circuit on a single MCM substrate

  2. FERMI multi-chip module

    CERN Multimedia

    This FERMI multi-chip module contains five million transistors. 25 000 of these modules will handle the flood of information through parts of the ATLAS and CMS detectors at the LHC. To select interesting events for recording, crucial decisions are taken before the data leaves the detector. FERMI modules are being developed at CERN in partnership with European industry.

  3. Multichip module technology for automotive application

    Science.gov (United States)

    Johnson, R. Wayne; Evans, John L.; Bosley, Larry

    1995-01-01

    Advancements in multichip module technology are creating design freedoms previously unavailable to design engineers. These advancements are opening new markets for laminate based multichip module products. In particular, material improvements in laminate printed wiring boards are allowing multichip module technology to meet more stringent environmental conditions. In addition, improvements in encapsulants and adhesives are enhancing the capabilities of multichip module technology to meet harsh environment. Furthermore, improvements in manufacturing techniques are providing the reliability improvements necessary for use in high quality electronic systems. These advances are making multichip module technology viable for high volume, harsh environment applications like under-the-hood automotive electronics. This paper will provide a brief review of multichip module technology, a discussion of specific research activities with Chrysler for use of multichip modules in automotive engine controllers and finally a discussion of prototype multichip modules fabricated and tested.

  4. Design specifications for manufacturability of MCM-C multichip modules

    Energy Technology Data Exchange (ETDEWEB)

    Allen, C.; Blazek, R.; Desch, J.; Elarton, J.; Kautz, D.; Markley, D.; Morgenstern, H.; Stewart, R.; Warner, L.

    1995-06-01

    The scope of this document is to establish design guidelines for electronic circuitry packaged as multichip modules of the ceramic substrate variety, although many of these guidelines are applicable to other types of multichip modules. The guidelines begin with prerequisite information which must be developed between customer and designer of the multichip module. The core of the guidelines focuses on the many considerations that must be addressed during the multichip module design. The guidelines conclude with the resulting deliverables from the design which satisfy customer requirements and/or support the multichip module fabrication and testing processes. Considerable supporting information, checklists, and design constraints are captured in specific appendices and used as reference information in the main body text. Finally some real examples of multichip module design are presented.

  5. Effects of Auxiliary-Source Connection in Multichip Power Module

    DEFF Research Database (Denmark)

    Li, Helong; Munk-Nielsen, Stig; Wang, Xiongfei

    2017-01-01

    the power loop and the gate loop like how the Kelvin-source connection does, owing to their involvement in the loop of the power source current. Three effects of the auxiliary-source connections are then analyzed, which are 1) the common source stray inductance reduction, 2) the transient drain......Auxiliary-source bond wires and connections are widely used in power modules with paralleled MOSFETs or IGBTs. This paper investigates the operation mechanism of the auxiliary-source connections in multichip power modules. It reveals that the auxiliary-source connections cannot fully decouple......-source current imbalance mitigation, and 3) the influence on the steady-state current distribution. Lastly, simulations and experimental results validate the theoretical analysis....

  6. A 240-channel thick film multi-chip module for readout of silicon drift detectors

    International Nuclear Information System (INIS)

    Lynn, D.; Bellwied, R.; Beuttenmueller, R.; Caines, H.; Chen, W.; DiMassimo, D.; Dyke, H.; Elliott, D.; Grau, M.; Hoffmann, G.W.; Humanic, T.; Jensen, P.; Kleinfelder, S.A.; Kotov, I.; Kraner, H.W.; Kuczewski, P.; Leonhardt, B.; Li, Z.; Liaw, C.J.; LoCurto, G.; Middelkamp, P.; Minor, R.; Mazeh, N.; Nehmeh, S.; O'Conner, P.; Ott, G.; Pandey, S.U.; Pruneau, C.; Pinelli, D.; Radeka, V.; Rescia, S.; Rykov, V.; Schambach, J.; Sedlmeir, J.; Sheen, J.; Soja, B.; Stephani, D.; Sugarbaker, E.; Takahashi, J.; Wilson, K.

    2000-01-01

    We have developed a thick film multi-chip module for readout of silicon drift (or low capacitance ∼200 fF) detectors. Main elements of the module include a custom 16-channel NPN-BJT preamplifier-shaper (PASA) and a custom 16-channel CMOS Switched Capacitor Array (SCA). The primary design criteria of the module were the minimizations of the power (12 mW/channel), noise (ENC=490 e - rms), size (20.5 mmx63 mm), and radiation length (1.4%). We will discuss various aspects of the PASA design, with emphasis on the preamplifier feedback network. The SCA is a modification of an integrated circuit that has been previously described [1]; its design features specific to its application in the SVT (Silicon Vertex Tracker in the STAR experiment at RHIC) will be discussed. The 240-channel multi-chip module is a circuit with five metal layers fabricated in thick film technology on a beryllia substrate and contains 35 custom and commercial integrated circuits. It has been recently integrated with silicon drift detectors in both a prototype system assembly for the SVT and a silicon drift array for the E896 experiment at the Alternating Gradient Synchrotron at the Brookhaven National Laboratory. We will discuss features of the module's design and fabrication, report the test results, and emphasize its performance both on the bench and under experimental conditions

  7. A Novel DBC Layout for Current Imbalance Mitigation in SiC MOSFET Multichip Power Modules

    DEFF Research Database (Denmark)

    Li, Helong; Munk-Nielsen, Stig; Beczkowski, Szymon

    2016-01-01

    This letter proposes a novel direct bonded copper (DBC) layout for mitigating the current imbalance among the paralleled SiC MOSFET dies in multichip power modules. Compared to the traditional layout, the proposed DBC layout significantly reduces the circuit mismatch and current coupling effect...

  8. Protecting integrated circuits from excessive charge accumulation during plasma cleaning of multichip modules

    Science.gov (United States)

    Rodenbeck, Christopher T; Girardi, Michael

    2015-04-21

    Internal nodes of a constituent integrated circuit (IC) package of a multichip module (MCM) are protected from excessive charge during plasma cleaning of the MCM. The protected nodes are coupled to an internal common node of the IC package by respectively associated discharge paths. The common node is connected to a bond pad of the IC package. During MCM assembly, and before plasma cleaning, this bond pad receives a wire bond to a ground bond pad on the MCM substrate.

  9. Symmetric and Programmable Multi-Chip Module for Low-Power Prototyping System

    OpenAIRE

    Yen, Mao-Hsu; Chen, Sao-Jie; Lan, Sanko H.

    2001-01-01

    The advantages of a Multi-Chip Module (MCM) product are its low-power and small-size. But the design of an MCM system usually requires weeks of engineering effort, thus we need a generic MCM substrate with programmable interconnections to accelerate system prototyping. In this paper, we propose a Symmetric and Programmable MCM (SPMCM) substrate for this purpose. This SPMCM substrate consists of a symmetrical array of slots for bare-chip attachment and Field Programmable Interco...

  10. An introduction to NASA's advanced computing program: Integrated computing systems in advanced multichip modules

    Science.gov (United States)

    Fang, Wai-Chi; Alkalai, Leon

    1996-01-01

    Recent changes within NASA's space exploration program favor the design, implementation, and operation of low cost, lightweight, small and micro spacecraft with multiple launches per year. In order to meet the future needs of these missions with regard to the use of spacecraft microelectronics, NASA's advanced flight computing (AFC) program is currently considering industrial cooperation and advanced packaging architectures. In relation to this, the AFC program is reviewed, considering the design and implementation of NASA's AFC multichip module.

  11. A Novel DBC Layout for Current Imbalance Mitigation in SiC MOSFET Multichip Power Modules

    DEFF Research Database (Denmark)

    Li, Helong; Munk-Nielsen, Stig; Beczkowski, Szymon

    2016-01-01

    This paper proposes a novel Direct Bonded Copper (DBC) layout for mitigating the current imbalance among the paralleled SiC MOSFET dies in multichip power modules. Compared to the traditional layout, the proposed DBC layout significantly reduces the circuit mismatch and current coupling effect......, which consequently improves the current sharing among the paralleled SiC MOSFET dies in power module. Mathematic analysis and circuit model of the DBC layout are presented to elaborate on the superior features of the proposed DBC layout. Simulation and experimental results further verify the theoretical...

  12. Numerical thermal analysis and optimization of multi-chip LED module using response surface methodology and genetic algorithm

    NARCIS (Netherlands)

    Tang, Hong Yu; Ye, Huai Yu; Chen, Xian Ping; Qian, Cheng; Fan, Xue Jun; Zhang, G.Q.

    2017-01-01

    In this paper, the heat transfer performance of the multi-chip (MC) LED module is investigated numerically by using a general analytical solution. The configuration of the module is optimized with genetic algorithm (GA) combined with a response surface methodology. The space between chips, the

  13. Parallel Connection of Silicon Carbide MOSFETs for Multichip Power Modules

    DEFF Research Database (Denmark)

    Li, Helong

    challenges from the manufacture and application points of view. The less mature manufacture process limits the yield and the single die size of the SiC MOSFETs, which results a smaller current capability of a single SiC MOSFET die. Consequently, in high current application, the paralleled connections of Si...... connections for the paralleled dies are presented and the source of the transient current imbalance is concluded. To mitigate the transient current imbalance in the traditional DBC layout, a novel DBC layout with split output is proposed. First, the working mechanism of the split output topology is studied...... the current sharing performance among the paralleled SiC MOSFET dies in the power module. The proposed DBC layout is not only limited for SiC MOSFETs, but also for Si IGBTs and other voltage controlled devices. of the circuit mismatch on the paralleled connection of SiC MOSFETs. It reveals the circuit...

  14. Circuit mismatch and current coupling effect influence on paralleling SiC MOSFETs in multichip power modules

    DEFF Research Database (Denmark)

    Li, Helong; Beczkowski, Szymon; Munk-Nielsen, Stig

    2015-01-01

    This paper reveals that there are circuit mismatches and a current coupling effect in the direct bonded copper (DBC) layout of a silicon carbide (SiC) MOSFET multichip power module. According to the modelling and the mathematic analysis of the DBC layout, the mismatch of the common source stray i...

  15. Influence of Paralleling Dies and Paralleling Half-Bridges on Transient Current Distribution in Multichip Power Modules

    DEFF Research Database (Denmark)

    Li, Helong; Zhou, Wei; Wang, Xiongfei

    2018-01-01

    This paper addresses the transient current distribution in the multichip half-bridge power modules, where two types of paralleling connections with different current commutation mechanisms are considered: paralleling dies and paralleling half-bridges. It reveals that with paralleling dies, both t...

  16. Thermal fatigue life evaluation of SnAgCu solder joints in a multi-chip power module

    Science.gov (United States)

    Barbagallo, C.; Malgioglio, G. L.; Petrone, G.; Cammarata, G.

    2017-05-01

    For power devices, the reliability of thermal fatigue induced by thermal cycling has been prioritized as an important concern. The main target of this work is to apply a numerical procedure to assess the fatigue life for lead-free solder joints, that represent, in general, the weakest part of the electronic modules. Starting from a real multi-chip power module, FE-based models were built-up by considering different conditions in model implementation in order to simulate, from one hand, the worst working condition for the module and, from another one, the module standing into a climatic test room performing thermal cycles. Simulations were carried-out both in steady and transient conditions in order to estimate the module thermal maps, the stress-strain distributions, the effective plastic strain distributions and finally to assess the number of cycles to failure of the constitutive solder layers.

  17. Thermal fatigue life evaluation of SnAgCu solder joints in a multi-chip power module

    International Nuclear Information System (INIS)

    Barbagallo, C; Petrone, G; Cammarata, G; Malgioglio, G L

    2017-01-01

    For power devices, the reliability of thermal fatigue induced by thermal cycling has been prioritized as an important concern. The main target of this work is to apply a numerical procedure to assess the fatigue life for lead-free solder joints, that represent, in general, the weakest part of the electronic modules. Starting from a real multi-chip power module, FE-based models were built-up by considering different conditions in model implementation in order to simulate, from one hand, the worst working condition for the module and, from another one, the module standing into a climatic test room performing thermal cycles. Simulations were carried-out both in steady and transient conditions in order to estimate the module thermal maps, the stress-strain distributions, the effective plastic strain distributions and finally to assess the number of cycles to failure of the constitutive solder layers. (paper)

  18. Study on the Thermal Resistance of Multi-chip Module High Power LED Packaging Heat Dissipation System

    Directory of Open Access Journals (Sweden)

    Kailin Pan

    2014-10-01

    Full Text Available Thermal resistance is a key technical index which indicates the thermal management of multi-chip module high power LED (MCM-LED packaging heat dissipation system. In this paper, the prototype structure of MCM-LED packaging heat dissipation system is proposed to study the reliable thermal resistance calculation method. In order to analyze the total thermal resistance of the MCM-LED packaging heat dissipation system, three kinds of thermal resistance calculation method including theoretical calculation, experimental testing and finite element simulation are developed respectively. Firstly, based on the thermal resistance network model and the principle of steady state heat transfer, the theoretical value of total thermal resistance is 6.111 K/W through sum of the thermal resistance of every material layer in the major direction of heat flow. Secondly, the thermal resistance experiment is carried out by T3Ster to obtain the experimental result of total thermal resistance, and the value is 6.729 K/W. Thirdly, a three-dimensional finite element model of MCM-LED packaging heat dissipation system is established, and the junction temperature experiment is also performed to calculated the finite element simulated result of total thermal resistance, the value is 6.99 K/W. Finally, by comparing the error of all the three kinds of result, the error of total thermal resistance between the theoretical value and experimental result is 9.2 %, and the error of total thermal resistance between the experimental result and finite element simulation is only about -3.9 %, meanwhile, the main reason of each error is discussed respectively.

  19. A mixed signal multi-chip module with high speed serial output links for the ATLAS Level-1 trigger

    CERN Document Server

    Pfeiffer, U

    2000-01-01

    We have built and tested a mixed signal multi-chip module (MCM) to be used in the Level-1 Pre-Processor system for the Calorimeter Trigger of the ATLAS experiment at CERN. The MCM performs high speed digital signal processing on four analogue input signals. Results are transmitted serially at a serial data rate of 800 MBd. Nine chips of different technologies are mounted on a four layer Cu substrate. ADC converters and serialiser chips are the major consumers of electrical power on the MCM, which amounts to 9 W for all dies. Special cut-out areas are used to dissipate heat directly to the copper substrate. In this paper we report on design criteria, chosen MCM technology for substrate and die mounting, experiences with the MCM operation and measurement results. (4 refs).

  20. A wafer-level multi-chip module process with thick photosensitive benzocyclobutene as the dielectric for microwave application

    International Nuclear Information System (INIS)

    Tang, Jiajie; Sun, Xiaowei; Luo, Le

    2011-01-01

    A wafer-level microwave multi-chip module (MMCM) packaging process is presented. Thick photosensitive-benzocyclobutene (photo-BCB) polymer (about 25 µm/layer) is used as the dielectric for its simplified process and the capability of obtaining desirable electrical, chemical and mechanical properties at high frequencies. The MMCM packaging structure contains a monolithic microwave integrated circuit (MMIC) chip embedded in a lossy-silicon wafer, a microwave band-pass filter (BPF) and two layers of BCB/Au interconnection. Key processes of fabrication are described in detail. The non-uniformity of BCB film and the sidewall angle of the via-holes for inter-layer connection are tested. Via-chains prepared by metal/BCB multilayer structures are tested through the Kelvin test structure to investigate the resistances of inter-layer connection. The average value is measured to be 73.5 mΩ. The electrical characteristic of this structure is obtained by a microwave transmission performance test from 15 to 30 GHz. The measurement results show good consistency between the bare MMIC die and the packaged die in the test frequency band. The gain of the MMIC chip after packaging is better than 18 dB within the designed operating frequency range (from 23 to 25 GHz). When the packaged MMIC chip is connected to a BPF, the maximum gain is still measured to reach 11.95 dB at 23.8 GHz

  1. A wafer-level 3D packaging structure with Benzocyclobutene as a dielectric for multichip module fabrication

    International Nuclear Information System (INIS)

    Geng Fei; Ding Xiaoyun; Xu Gaowei; Luo Le

    2009-01-01

    A new wafer-level 3D packaging structure with Benzocyclobutene (BCB) as interlayer dielectrics (ILDs) for multichip module fabrication is proposed for application in the Ku-band wave. The packaging structure consists of two layers of BCB films and three layers of metallized films, in which the monolithic microwave IC (MMIC), thin film resistors, striplines and microstrip lines are integrated. Wet etched cavities fabricated on the silicon substrate are used for mounting active and passive components. BCB layers cover the components and serve as ILDs for interconnections. Gold bumps are used as electric interconnections between different layers, which eliminates the need to prepare vias by costly dry etching and deposition processes. In order to get high-quality BCB films for the subsequent chemical mechanical planarization (CMP) and multilayer metallization processes, the BCB curing profile is optimized and the roughness of the BCB film after the CMP process is kept lower than 10 nm. The thermal, mechanical and electrical properties of the packaging structure are investigated. The thermal resistance can be controlled below 2 0 C/W. The average shear strength of the gold bumps on the BCB surface is around 70 N/mm 2 . The performances of MMIC and interconnection structure at high frequencies are optimized and tested. The S-parameters curves of the packaged MMIC shift slightly showing perfect transmission character. The insertion loss change after the packaging process is less than 1 dB range at the operating frequency and the return loss is less than -8 dB from 10 to 15 GHz.

  2. Silicon-Carbide (SIC) Multichip Power Modules (MCPMS) For Power Building Block Applications, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovation Research Phase I project seeks to prove the feasibility of developing high power density modular power electronic building blocks...

  3. Tunneling Accelerometer Multichip Module

    Science.gov (United States)

    Boyadzhyan, V. V.; Choma, J., Jr.

    1998-01-01

    This paper summarizes and reports a radiation hardened Spacecraft Integrated Sensor/Circut Technology that has been delivered for flight applications to be flown on board STRV-2 (Space Technology Research Vehicle-2).

  4. System issues for multichip packaging

    Science.gov (United States)

    Sage, Maurice G.; Hartley, Neil

    1991-04-01

    It is now generally recognised that the performance of an electronic system is governed by the choice of packaging technology. Never before have the technical and financial implications of a packaging technology choice been more critical and never before has technology interdependence or industry globalisation made the choice more difficult. This paper is aimed at examining the choices available and the system issues resulting from the move from single chip to multichip packaging.

  5. An analog silicon retina with multichip configuration.

    Science.gov (United States)

    Kameda, Seiji; Yagi, Tetsuya

    2006-01-01

    The neuromorphic silicon retina is a novel analog very large scale integrated circuit that emulates the structure and the function of the retinal neuronal circuit. We fabricated a neuromorphic silicon retina, in which sample/hold circuits were embedded to generate fluctuation-suppressed outputs in the previous study [1]. The applications of this silicon retina, however, are limited because of a low spatial resolution and computational variability. In this paper, we have fabricated a multichip silicon retina in which the functional network circuits are divided into two chips: the photoreceptor network chip (P chip) and the horizontal cell network chip (H chip). The output images of the P chip are transferred to the H chip with analog voltages through the line-parallel transfer bus. The sample/hold circuits embedded in the P and H chips compensate for the pattern noise generated on the circuits, including the analog communication pathway. Using the multichip silicon retina together with an off-chip differential amplifier, spatial filtering of the image with an odd- and an even-symmetric orientation selective receptive fields was carried out in real time. The analog data transfer method in the present multichip silicon retina is useful to design analog neuromorphic multichip systems that mimic the hierarchical structure of neuronal networks in the visual system.

  6. Development of highly durable deep-ultraviolet AlGaN-based LED multichip array with hemispherical encapsulated structures using a selected resin through a detailed feasibility study

    Science.gov (United States)

    Nagai, Shoko; Yamada, Kiho; Hirano, Akira; Ippommatsu, Masamichi; Ito, Masahiro; Morishima, Naoki; Aosaki, Ko; Honda, Yoshio; Amano, Hiroshi; Akasaki, Isamu

    2016-08-01

    To replace mercury lamps with AlGaN-based deep-ultraviolet (DUV) LEDs, a simple and low-cost package with increased light extraction efficiency (LEE) is indispensable. Therefore, resin encapsulation is considered to be a key technology. However, the photochemical reactions induced by DUV light cause serious problems, and conventional resins cannot be used. In the former part of this study, a comparison of a silicone resin and fluorine polymers was carried out in terms of their suitability for encapsulation, and we concluded that only one of the fluorine polymers can be used for encapsulation. In the latter part, the endurance of encapsulation using the selected fluorine polymer was investigated, and we confirmed that the selected fluorine polymer can guarantee a lifetime of over 6,000 h at a wavelength of 265 nm. Furthermore, a 3 × 4 array module of encapsulated dies on a simple AlN submount was fabricated, demonstrating the possibility of W/cm2-class lighting.

  7. Studies on MCM-D pixel-detector-modules

    CERN Document Server

    Flick, T; Gerlach, P; Grah, C; Mättig, P; Rohe, T

    2003-01-01

    In the context of the development of the ATLAS-pixel-detector, a technology for building up the high density interconnects has been studied, the MCM-D (multichip module deposited) technology. Results of building up first assemblies have been reported. MCM-D technology allows to build up assemblies with uniformly segmented sensors. Especially the use of 'equal-sized(-bricked)' sensor geometry has been studied.

  8. Analog integrated circuit for micro-gyro interface realized by multi-chip service in Japan; Multi chip service ni yoru micro gyro interface shuseki kairo no sekkei to shisaku

    Energy Technology Data Exchange (ETDEWEB)

    Maenaka, K.; Fujita, T.; Okamoto, K.; Maeda, M. [Himeji Institute of Technology, Hyogo (Japan)

    1998-10-01

    This paper deals with an analog integrated circuit for micro-machined gyroscopes with capacitive output. The Integrated circuit was fabricated as a part of the first project from the `Micromachining Multi-Chip Service Cooperative Re-search Committee` organized by The Institute of Electrical Engineers Japan. This multi-chip service project offers a master slice chip with an equivalent of 9 blocks of operational amplifier circuits. Our integrated circuit includes a modulator, demodulator and synchronous rectifier for detecting small changes in the capacitance of a silicon gyroscope. In the paper, the experimental results of fabricated samples will be described. 13 refs., 15 figs.

  9. A multi-chip module for physics experiments

    CERN Document Server

    Benso, A; Giovannetti, S; Mariani, R; Motto, S; Prinetto, P

    1999-01-01

    MCMs are widely adopted as assembly solutions for multi-die based systems, where area, performance, and costs are critical constraints. This paper describes both the project strategies and production flow that are to be adopted to realize an MCM-D for data acquisition in high-energy physics experiments. The activity starts from the results of RD/16 CERN project, and is part of the LAP Esprit project. The paper details the most critical issues faced in the production phase, and analyzes how they influenced system partitioning and component design. Moreover, it presents the design-for-testability methodologies adopted at both chip and MCM levels to achieve low defect levels and high production yields, minimizing the overhead in terms of system performance and area occupation. This work should demonstrate the feasibility of the MCM technology in such high speed data processing systems, where both size and cost constraints are important. (10 refs).

  10. Materials Research for GHz Multi-Chip Modules

    Science.gov (United States)

    1993-09-30

    Publications: Laursen, K., Hertling, D., Berry, N., Bidstrup, S.A., Kohl, P., and Arroz , A., "Measurement of the Electrical Properties of Hligh Performance...Materials, Fall 1992. Herding, D.R., Laursen, K., Bidstrup, S.A., Kohl, P.A., Arroz , G.S.., "Measurement of the Electrical Properties of High

  11. Selective Attention in Multi-Chip Address-Event Systems

    Directory of Open Access Journals (Sweden)

    Giacomo Indiveri

    2009-06-01

    Full Text Available Selective attention is the strategy used by biological systems to cope with the inherent limits in their available computational resources, in order to efficiently process sensory information. The same strategy can be used in artificial systems that have to process vast amounts of sensory data with limited resources. In this paper we present a neuromorphic VLSI device, the “Selective Attention Chip” (SAC, which can be used to implement these models in multi-chip address-event systems. We also describe a real-time sensory-motor system, which integrates the SAC with a dynamic vision sensor and a robotic actuator. We present experimental results from each component in the system, and demonstrate how the complete system implements a real-time stimulus-driven selective attention model.

  12. Selective attention in multi-chip address-event systems.

    Science.gov (United States)

    Bartolozzi, Chiara; Indiveri, Giacomo

    2009-01-01

    Selective attention is the strategy used by biological systems to cope with the inherent limits in their available computational resources, in order to efficiently process sensory information. The same strategy can be used in artificial systems that have to process vast amounts of sensory data with limited resources. In this paper we present a neuromorphic VLSI device, the "Selective Attention Chip" (SAC), which can be used to implement these models in multi-chip address-event systems. We also describe a real-time sensory-motor system, which integrates the SAC with a dynamic vision sensor and a robotic actuator. We present experimental results from each component in the system, and demonstrate how the complete system implements a real-time stimulus-driven selective attention model.

  13. Development of GREET Catalyst Module

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhichao [Argonne National Lab. (ANL), Argonne, IL (United States); Benavides, Pahola T. [Argonne National Lab. (ANL), Argonne, IL (United States); Dunn, Jennifer B. [Argonne National Lab. (ANL), Argonne, IL (United States); Cronauer, Donald C. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-09-01

    In this report, we develop energy and material flows for the production of five different catalysts (tar reforming, alcohol synthesis, Zeolite Socony Mobil-5 [ZSM-5], Mo/Co/ γ-Al2O3, and Pt/ γ-Al2O3) and two chemicals (olivine, dimethyl ether of polyethylene glycol [DEPG]). These compounds and catalysts are now included in the Greenhouse Gases, Regulated Emissions and Energy Use in Transportation (GREET™) catalyst module.

  14. Development of GREET Catalyst Module

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhichao [Argonne National Lab. (ANL), Argonne, IL (United States). Energy Systems Division; Dunn, Jennifer B. [Argonne National Lab. (ANL), Argonne, IL (United States). Energy Systems Division; Cronauer, Donald C. [Argonne National Lab. (ANL), Argonne, IL (United States). Energy Systems Division

    2014-09-01

    Catalysts are critical inputs for many pathways that convert biomass into biofuels. Energy consumption and greenhouse gas (GHG) emissions during the production of catalysts and chemical inputs influence the life-cycle energy consumption, and GHG emissions of biofuels and need to be considered in biofuel life-cycle analysis (LCA). In this report, we develop energy and material flows for the production of three different catalysts (tar reforming, alcohol synthesis, Zeolite Socony Mobil-5 [ZSM-5]) and two chemicals (olivine, dimethyl ether of polyethylene glycol [DEPG]). These compounds and catalysts are now included in the Greenhouse Gases, Regulated Emissions and Energy Use in Transportation (GREET™) catalyst module. They were selected because they are consumed in existing U.S. Department of Energy (DOE) analyses of biofuel processes. For example, a thermochemical ethanol production pathway (indirect gasification and mixed alcohol synthesis) developed by the National Renewable Energy Laboratory (NREL) uses olivine, DEPG, and tar reforming and alcohol synthesis catalysts (Dutta et al., 2011). ZSM-5 can be used in biofuel production pathways such as catalytic upgrading of sugars into hydrocarbons (Biddy and Jones, 2013). Other uses for these compounds and catalysts are certainly possible. In this report, we document the data sources and methodology we used to develop material and energy flows for the catalysts and compounds in the GREET catalyst module. In Section 2 we focus on compounds used in the model Dutta et al. (2011) developed. In Section 3, we report material and energy flows associated with ZSM-5 production. Finally, in Section 4, we report results.

  15. Photovoltaic module energy rating methodology development

    Energy Technology Data Exchange (ETDEWEB)

    Kroposki, B.; Myers, D.; Emery, K.; Mrig, L. [National Renewable Energy Lab., Golden, CO (United States); Whitaker, C.; Newmiller, J. [Endecon Engineering, San Ramon, CA (United States)

    1996-05-01

    A consensus-based methodology to calculate the energy output of a PV module will be described in this paper. The methodology develops a simple measure of PV module performance that provides for a realistic estimate of how a module will perform in specific applications. The approach makes use of the weather data profiles that describe conditions throughout the United States and emphasizes performance differences between various module types. An industry-representative Technical Review Committee has been assembled to provide feedback and guidance on the strawman and final approach used in developing the methodology.

  16. Instructor's Guide for Human Development Student Modules.

    Science.gov (United States)

    South Carolina State Dept. of Education, Columbia. Office of Vocational Education.

    This instructor's guide is designed for use with an accompanying set of 61 student learning modules on human development. Included among the topics covered in the individual modules are the following: consumer and homemaking education (health and nutrition, personal appearance and grooming, puberty, menstruation, the human reproductive system,…

  17. Getting started with Magento module development

    CERN Document Server

    Ajzele, Branko

    2013-01-01

    This project-based tutorial gives you a strong foundation and guides you through practical, real-world examples.This book contains valuable insights for both newbies and already established Magento developers. This book is targeted at new and intermediate PHP developers starting afresh with Magento module development.

  18. Technology transfer of military space microprocessor developments

    Science.gov (United States)

    Gorden, C.; King, D.; Byington, L.; Lanza, D.

    1999-01-01

    Over the past 13 years the Air Force Research Laboratory (AFRL) has led the development of microprocessors and computers for USAF space and strategic missile applications. As a result of these Air Force development programs, advanced computer technology is available for use by civil and commercial space customers as well. The Generic VHSIC Spaceborne Computer (GVSC) program began in 1985 at AFRL to fulfill a deficiency in the availability of space-qualified data and control processors. GVSC developed a radiation hardened multi-chip version of the 16-bit, Mil-Std 1750A microprocessor. The follow-on to GVSC, the Advanced Spaceborne Computer Module (ASCM) program, was initiated by AFRL to establish two industrial sources for complete, radiation-hardened 16-bit and 32-bit computers and microelectronic components. Development of the Control Processor Module (CPM), the first of two ASCM contract phases, concluded in 1994 with the availability of two sources for space-qualified, 16-bit Mil-Std-1750A computers, cards, multi-chip modules, and integrated circuits. The second phase of the program, the Advanced Technology Insertion Module (ATIM), was completed in December 1997. ATIM developed two single board computers based on 32-bit reduced instruction set computer (RISC) processors. GVSC, CPM, and ATIM technologies are flying or baselined into the majority of today's DoD, NASA, and commercial satellite systems.

  19. Design and development of CAMAC test module

    International Nuclear Information System (INIS)

    Kulkarni, S.G.; Gore, J. A.; Gupta, A.K.; Saxena, A.

    2015-01-01

    Various Computer automated measurement and control (CAMAC) modules are used in control and monitoring of Pelletron Accelerator. 24 channels CAMAC Input Gate is used for getting the ON/OFF status of various devices in the Pelletron Accelerator. If a channel has 24 V then the status is 'ON' and if the channel receives 0 V then the status is 'OFF'. Hence we can get the status of 24 different channels though one CAMAC Input Gate module. The status is transported to the PC via CAMAC controller. The manual testing of CAMAC Input Gate involves connection of 24 V to each channel and checking the status of each channel with Graphical user interface (GUI) software. This process of checking input gate is automated by developing a CAMAC Test module which is connected to CAMAC Input Gate with a 50 pin ribbon cable. The Test module automatically generates 24 V /0 V on each channel to be tested depending on the software GUI buttons labeled as 'ON'/'OFF' in labview. The status of CAMAC Input Gate is displayed on GUI for all 24 channels. Hence the user can check the working of each channel on GUI written in labview. This automated process of checking the CAMAC Input Gate saves time to debug problems in module and identifying the bad channel which can be subsequently repaired. The CAMAC Test module uses Spartan 2 FPGA which is connected to 24 transistors which in turn operates 24 relays. 24 V supply is connected to the relay secondary contacts which open/close as per the transistor inputs. The 24 V contacts are connected to the module output connector which should be connected to CAMAC Input Gate which is to be tested. (author)

  20. The Advances, Challenges and Future Possibilities of Millimeter-Wave Chip-to-Chip Interconnections for Multi-Chip Systems

    Directory of Open Access Journals (Sweden)

    Amlan Ganguly

    2018-02-01

    Full Text Available With aggressive scaling of device geometries, density of manufacturing faults is expected to increase. Therefore, yield of complex Multi-Processor Systems-on-Chips (MP-SoCs will decrease due to higher probability of manufacturing defects especially, in dies with large area. Therefore, disintegration of large SoCs into smaller chips called chiplets will improve yield and cost of complex platform-based systems. This will also provide functional flexibility, modular scalability as well as the capability to integrate heterogeneous architectures and technologies in a single unit. However, with scaling of the number of chiplets in such a system, the shared resources in the system such as the interconnection fabric and memory modules will become performance bottlenecks. Additionally, the integration of heterogeneous chiplets operating at different frequencies and voltages can be challenging. State-of-the-art inter-chip communication requires power-hungry high-speed I/O circuits and data transfer over long wired traces on substrates. This increases energy consumption and latency while decreasing data bandwidth for chip-to-chip communication. In this paper, we explore the advances and the challenges of interconnecting a multi-chip system with millimeter-wave (mm-wave wireless interconnects from a variety of perspectives spanning multiple aspects of the wireless interconnection design. Our discussion on the recent advances include aspects such as interconnection topology, physical layer, Medium Access Control (MAC and routing protocols. We also present some potential paradigm-shifting applications as well as complementary technologies of wireless inter-chip communications.

  1. A multichip aVLSI system emulating orientation selectivity of primary visual cortical cells.

    Science.gov (United States)

    Shimonomura, Kazuhiro; Yagi, Tetsuya

    2005-07-01

    In this paper, we designed and fabricated a multichip neuromorphic analog very large scale integrated (aVLSI) system, which emulates the orientation selective response of the simple cell in the primary visual cortex. The system consists of a silicon retina and an orientation chip. An image, which is filtered by a concentric center-surround (CS) antagonistic receptive field of the silicon retina, is transferred to the orientation chip. The image transfer from the silicon retina to the orientation chip is carried out with analog signals. The orientation chip selectively aggregates multiple pixels of the silicon retina, mimicking the feedforward model proposed by Hubel and Wiesel. The chip provides the orientation-selective (OS) outputs which are tuned to 0 degrees, 60 degrees, and 120 degrees. The feed-forward aggregation reduces the fixed pattern noise that is due to the mismatch of the transistors in the orientation chip. The spatial properties of the orientation selective response were examined in terms of the adjustable parameters of the chip, i.e., the number of aggregated pixels and size of the receptive field of the silicon retina. The multichip aVLSI architecture used in the present study can be applied to implement higher order cells such as the complex cell of the primary visual cortex.

  2. Status of development of the HTR module

    International Nuclear Information System (INIS)

    Weisbrodt, I.A.

    1989-01-01

    Growing concern about the rising global temperature of the earth due to the ''Greenhouse Effect'' is increasingly focussing worldwide interest on passively safe reactors for heat and power production. In this context the development status of the HTR-Module designed by the Siemens-Group merits strong interest. The HTR-Module has a high degree of passive safety features. Even in case of hypothetical accidents the decay heat is dissipated from the primary system to the environment by passive measures alone i.e. by heat conduction, convection and radiation. The detailed engineering for the HTR-Module continues to progress. In addition to the engineering for the layout considerable progress has been made in the detailed engineering for specific components - e.g. pressure vessel, steam generator, hot gas duct, blower etc. - and specific systems - e.g. first core, helium purification system, reactor safety system, reactor control etc. The procedure for the conceptual licence has been continued. A large number of supplementary analyses and reports have been elaborated and submitted for this procedure. Many workshop meetings have been held with the nominated experts. The hypothetical accidents have been analysed and a special report on these accidents has been submitted. The safety analyses report has been revised, taking into account the results and achievements reached during the ongoing licensing procedure. Parallel to these engineering activities outstanding in R and D work for the HTR-Module, e.g. in the field of fuel elements etc. has been continued. The HTR-Module has found worldwide interest. Respective activities are going on in Bangladesh, PR China, USSR, Indonesia etc. Relevant application studies have been carried out and/or initiated. (author). 15 refs, 16 figs

  3. Pulse modulator developments in support of klystron testing at SLAC

    International Nuclear Information System (INIS)

    Koontz, R.F.; Cassel, R.; Lamare, J. de; Ficklin, D.; Gold, S.; Harris, K.

    1993-01-01

    Several families of high power klystrons in S- and X-Band are being developed in the Klystron Laboratory at SLAC. To support these developments, a number of new pulse modulators are being designed from scratch, or upgraded from existing laboratory test modulators. This paper outlines the modulator parameters available in the SLAC Klystron Laboratory, and discuss two new modulators that are under construction

  4. Development of coincidence processing module for PEM

    International Nuclear Information System (INIS)

    Feng Baotong; Shuai Lei; Li Ke

    2011-01-01

    For the breast cancer diagnosis and therapy, a prototype of positron emission mammography (PEM) was developed in Institute of High Energy Physics, Chinese Academy of Sciences. In this paper, the design of coincidence processing module (CPM) for this PEM was presented. Both the hardware architecture and the software logic were introduced. In this design, the CPM used the Rocket IO fast interface in FPGA and fiber technology to acquire the preprocessed data from the continuous sampling module (CSM) and then selected the valid event with the coincidence timing window method, which was performed in the FPGA on the daughter board. The CPM transmits the processed data to host computer via gigabit Ethernet. The whole system was controlled by CAN bus. The primary tests indicate that the performance of this design is good. (authors)

  5. Developing disaster management modules: a collaborative approach.

    Science.gov (United States)

    Douglas, Valerie

    Disasters, whether natural or human induced, can strike when least expected. The events of 9/11 in the US, the 7/7 bombings in the UK, and the anthrax incident in the US on 10th October 2001 indicate that there is a need to have a nursing workforce who is able to respond effectively to mass casualty events and incidents involving chemical, biological, radiological and nuclear substances. Multi-agency collaboration is one of the fundamental principles of disaster preparedness and response. It was therefore necessary to take a similar multi-agency collaborative approach to develop modules on the management of mass casualty events and incidents involving hazardous substances. The modules are offered to registered nurses and registered paramedics. They can be taken independently or as part of a BSc in nursing or health pathway, on a part-time basis. Since the commencement of the modules in September 2004, registered paramedics and registered nurses who work in a wide range of specialties have accessed them.

  6. Model Development of Degradation of PV Modules Backsheet with Locating Place of Module

    Energy Technology Data Exchange (ETDEWEB)

    Kempe, Michael D [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Wang, Yu [Case Western Reserve University; Fairbrother, Andrew [National Institute of Standards and Technology (NIST); Merzlic, Sebastien [Arkema; Julien, Scott [Northeastern University; Fridman, Lucas S. [Case Western Reserve University; Loyer, Camille [Arkema; Lefebvre, Amy L. [Arkema; O' Brien, Gregory [Arkema; Gu, Xiaohong [National Institute of Standards and Technology (NIST); Ji, Liang [Underwriters Laboratories; Boyce, Kenneth P. [Underwriters Laboratories; Wan, Kai-tak [Northeastern University; French, Roger H. [Case Western Reserve University; Bruckman, Laura S. [Case Western Reserve University

    2017-08-23

    Performance of a photovoltaic (PV) module is related to the micro-environment around the module. The position of photovoltaic modules in an array row have a large effect on the yellowing and gloss of PV module backsheet exposed in Dfa climatic zone (Gaithersburg, MD) with a polyethylene naphthalate (PEN) outer layer. Stress/Response models of yellowing and gloss-losing as function of location parameters of module, including the shed, row, measurement position in a same module and the distance of module location to the row center, are under development. The module installation height had the greatest influence on degradation of PEN PV backsheet in the Dfa climatic zone. The module backsheets at the end of an array have higher degradation rate (edge effect). The edge effect decreases with increasing of module installation heights.

  7. Broad Frequency LTCC Vertical Interconnect Transition for Multichip Modules and System on Package Applications

    Science.gov (United States)

    Decrossas, Emmanuel; Glover, Michael D.; Porter, Kaoru; Cannon, Tom; Mantooth, H. Alan; Hamilton, M. C.

    2013-01-01

    Various stripline structures and flip chip interconnect designs for high-speed digital communication systems implemented in low temperature co-fired ceramic (LTCC) substrates are studied in this paper. Specifically, two different transition designs from edge launch 2.4 millimeter connectors to stripline transmission lines embedded in LTCC are discussed. After characterizing the DuPont (sup trademark) 9K7 green tape, different designs are proposed to improve signal integrity for high-speed digital data. The full-wave simulations and experimental data validate the presented designs over a broad frequency band from Direct Current to 50 gigahertz and beyond.

  8. Cell module and fuel conditioner development

    Science.gov (United States)

    Hoover, D. Q., Jr.

    1980-01-01

    Components for the first 5 cell stack (no cooling plates) of the MK-2 design were fabricated. Preliminary specfications and designs for the components of a 23 cell MK-1 stack with four DIGAS cooling plates were developed. The MK-2 was selected as a bench mark design and a preliminary design of the facilities required for high rate manufacture of fuel cell modules was developed. Two stands for testing 5 cell stacks were built and design work for modifying existing stands and building new stands for 23 and 80 cell stacks was initiated. Design and procurement of components and materials for the catalyst test stand were completed and construction initiated. Work on the specifications of pipeline gas, tap water and recovered water and definition of equipment required for treatment was initiated. An innovative geometry for the reformer was conceived and modifications of the computer program to be used in its design were stated.

  9. Development of RFS. NUCIRC Interaction Module

    International Nuclear Information System (INIS)

    Choi, Geun Suk; Park, Joo Hwan

    2010-01-01

    For heavy water reactor core analysis and thermal hydraulic analysis, RFSP code and the NUCIRC code should be used consecutively. In this case the result of computation of one program is used for input data and information of the other program. For example, it is determining the channel flow distribution of 100% power from the NUCIRC code by using time-averaged bundle power distribution data of 100% power calculated from the RFSP code. However, a result of coming out of the RFSP code don't give converged input data about bundle power. Because of that, it calculates many times and it has to deliver with NUCIRC input. The troublesome process calculated by the PYTHON program. PYTHON is the script language. The connected python module of the RFSP code and NUCIRC code were developed in order to overcome this disadvantage. The Modeling is CANDU 6 reactor

  10. Dual Arm Work Module Development and Appplications

    Energy Technology Data Exchange (ETDEWEB)

    Noakes, M.W.

    1999-04-25

    The dual arm work module (DAWM) was developed at Oak Ridge National Laboratory (ORNL) by the Robotics Technology Development Program (RTDP) as a development test bed to study issues related to dual arm manipulation, including platform cotilguration, controls, automation, operations, and tooling. The original platform was based on two Schilling Titan II manipulators mounted to a 5-degree-of- freedom (DOF) base fabricated by RedZone Robotics, Inc. The 5-DOF articulation provided a center torso rotation, linear actuation to change the separation between the arms, and arm base rotation joints to provide "elbows up," elbows down," or "elbows out" orientation. A series of tests were conducted on operations, tooling, and task space scene analysis (TSSA)-driven robotics for overhead transporter- mounted and crane hook-deployed scenarios. A concept was developed for DAWM deployment from a large remote work vehicle, but the project was redirected to support dismantlement of the Chicago Pile #5 (CP-5) reactor at Argonne National Laboratory in fiscal year (FY) 1997. Support of CP-5 required a change in focus of the dual arm technology from that of a development test bed to a system focussed for a specific end user. ORNL teamed with the Idaho National Environmental ,Engineering Laboratory, Sandia National Laboratory, and the Savannah River Technology Center to deliver a crane-deployed derivative of the DAWM, designated the dual arm work platform (DAWP). RTDP staff supported DAWP at CP-5 for one FY; Argonne staff continued operation through to dismantlement of the reactor internals. Lessons learned from this interaction were extensive. Beginning in FY 1999, dual arm development activities are again being pursued in the context of those lessons learned. This paper describes the progression of philosophy of the DAWM from initial test bed to lessons learned through interaction at CP-5 and to the present investigation of telerobotic assist of teleoperation and TSSA- driven robotics.

  11. Development of an electro-optic super modulator

    International Nuclear Information System (INIS)

    Cusack, B; Shaddock, D.

    2002-01-01

    Full text: Optical phase modulators and amplitude modulators are commonplace in modern laser laboratories. In this talk, we present the development of a device that produces both amplitude modulation (AM) and phase modulation (PM), with a selectable phase relation between the two, on a single free-space Gaussian beam. We term this device a 'super modulator. The device is a version of the Mach-Zehnder modulator, where a beam is split, then separately phase modulated and recombined. Previous work has concentrated on one specific operating point, where the relative modulation phases and the interferometer phase are set to generate single sideband modulation, equivalent to an equal amount of AM and PM in quadrature. Here we are interested in the entire parameter space of amplitude modulation strength, phase modulation strength, and the phase relation between the two. The need for such a super modulator has arisen in the context of control systems for gravitational wave detection interferometers. Typical locking systems are based on the Pound-Drever-Hall method of locking which uses phase modulation. In principle, a super modulator could be used in a PDH configuration, when the locking point of the device will be tunable according to the quantity of AM injected (along with the obligatory PM) into the device

  12. Custom chipset and compact module design for a 75–110 GHz laboratory signal source

    International Nuclear Information System (INIS)

    Morgan, Matthew A; Boyd, Tod A; Castro, Jason J

    2016-01-01

    We report on the development and characterization of a compact, full-waveguide bandwidth (WR-10) signal source for general-purpose testing of mm-wave components. The monolithic microwave integrated circuit (MMIC) based multichip module is designed for compactness and ease-of-use, especially in size-constrained test sets such as a wafer probe station. It takes as input a cm-wave continuous-wave (CW) reference and provides a factor of three frequency multiplication as well as amplification, output power adjustment, and in situ output power monitoring. It utilizes a number of custom MMIC chips such as a Schottky-diode limiter and a broadband mm-wave detector, both designed explicitly for this module, as well as custom millimeter-wave multipliers and amplifiers reported in previous papers. (paper)

  13. Neuromorphic VLSI Models of Selective Attention: From Single Chip Vision Sensors to Multi-chip Systems.

    Science.gov (United States)

    Indiveri, Giacomo

    2008-09-03

    Biological organisms perform complex selective attention operations continuously and effortlessly. These operations allow them to quickly determine the motor actions to take in response to combinations of external stimuli and internal states, and to pay attention to subsets of sensory inputs suppressing non salient ones. Selective attention strategies are extremely effective in both natural and artificial systems which have to cope with large amounts of input data and have limited computational resources. One of the main computational primitives used to perform these selection operations is the Winner-Take-All (WTA) network. These types of networks are formed by arrays of coupled computational nodes that selectively amplify the strongest input signals, and suppress the weaker ones. Neuromorphic circuits are an optimal medium for constructing WTA networks and for implementing efficient hardware models of selective attention systems. In this paper we present an overview of selective attention systems based on neuromorphic WTA circuits ranging from single-chip vision sensors for selecting and tracking the position of salient features, to multi-chip systems implement saliency-map based models of selective attention.

  14. Neuromorphic VLSI Models of Selective Attention: From Single Chip Vision Sensors to Multi-chip Systems

    Directory of Open Access Journals (Sweden)

    Giacomo Indiveri

    2008-09-01

    Full Text Available Biological organisms perform complex selective attention operations continuously and effortlessly. These operations allow them to quickly determine the motor actions to take in response to combinations of external stimuli and internal states, and to pay attention to subsets of sensory inputs suppressing non salient ones. Selective attention strategies are extremely effective in both natural and artificial systems which have to cope with large amounts of input data and have limited computational resources. One of the main computational primitives used to perform these selection operations is the Winner-Take-All (WTA network. These types of networks are formed by arrays of coupled computational nodes that selectively amplify the strongest input signals, and suppress the weaker ones. Neuromorphic circuits are an optimal medium for constructing WTA networks and for implementing efficient hardware models of selective attention systems. In this paper we present an overview of selective attention systems based on neuromorphic WTA circuits ranging from single-chip vision sensors for selecting and tracking the position of salient features, to multi-chip systems implement saliency-map based models of selective attention.

  15. The MARX Modulator Development Program for the International Linear Collider

    International Nuclear Information System (INIS)

    Leyh, G.E.

    2006-01-01

    The International Linear Collider (ILC) Marx Modulator Development Program at SLAC is working towards developing a full-scale ILC Marx ''Reference Design'' modulator prototype, with the goal of significantly reducing the size and cost of the ILC modulator while improving overall modulator efficiency and availability. The ILC Reference Design prototype will provide a proof-of-concept model to industry in advance of Phase II SBIR funding, and also allow operation of the new 10MW L-Band Klystron prototypes immediately upon their arrival at SLAC

  16. Development of control system for the electron gun modulator

    International Nuclear Information System (INIS)

    Hasegawa, T.; Nagasawa, S.; Kobayashi, T.; Hanaki, H.

    2004-01-01

    We have been developing a compact and inexpensive electron gun modulator for the SPring-8 Linac. The modulator was redesigned and manufactured to achieve good maintainability and high controllability. A control system of the modulator and a high voltage station is composed mainly of PLCs as a controller and touch panels for human interface. This simplified construction will result in enhancement of its reliability. The rich graphical user interface on the touch panels greatly extends the function of the control system. (author)

  17. VLSI 'smart' I/O module development

    Science.gov (United States)

    Kirk, Dan

    The developmental history, design, and operation of the MIL-STD-1553A/B discrete and serial module (DSM) for the U.S. Navy AN/AYK-14(V) avionics computer are described and illustrated with diagrams. The ongoing preplanned product improvement for the AN/AYK-14(V) includes five dual-redundant MIL-STD-1553 channels based on DSMs. The DSM is a front-end processor for transferring data to and from a common memory, sharing memory with a host processor to provide improved 'smart' input/output performance. Each DSM comprises three hardware sections: three VLSI-6000 semicustomized CMOS arrays, memory units to support the arrays, and buffers and resynchronization circuits. The DSM hardware module design, VLSI-6000 design tools, controlware and test software, and checkout procedures (using a hardware simulator) are characterized in detail.

  18. Getting started with OpenCart module development

    CERN Document Server

    Nepali, Rupak

    2013-01-01

    Written as a step-by-step guide, Getting Started with OpenCart Module Development will teach you all you need to know about OpenCart, from custom extensions to module development.This book is for developers who want to develop OpenCart extensions and for those who want to learn more about the code workflow of OpenCart. Basic knowledge of OpenCart would be an added advantage.

  19. Development of 10kW SOFC module

    Energy Technology Data Exchange (ETDEWEB)

    Hisatome, N.; Nagata, K. [Mitsubishi Heavy Industries, Ltd., Nagasaki (Japan); Kakigami, S. [Electric Power Development Co., Inc., Tokyo (Japan)] [and others

    1996-12-31

    Mitsubishi Heavy industries, Ltd. (MHI) has been developing tubular type Solid Oxide Fuel Cells (SOFC) since 1984. A 1 kW module of SOFC has been continuously operated for 3,000 hours with 2 scheduled thermal cycles at Electric Power Development Co., Inc. (EPDC) Wakamatsu Power Station in 1993. We have obtained of 34% (HHV as H{sub 2}) module efficiency and deterioration rate of 2% Per 1,000 hours in this field test. As for next step, we have developed 10 kW module in 1995. The 10 kW module has been operated for 5,000 hours continuously. This module does not need heating support to maintain the operation temperature, and the module efficiency was 34% (HHV as H{sub 2}). On the other hand, we have started developing the technology of pressurized SOFC. In 1996, pressurized MW module has been tested at MHI Nagasaki Shipyard & Machinery, Works. We are now planning the development of pressurized 10 kW module.

  20. Development and deployment of innovative distance education modules

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, Wen-Hsing [Nuclear Science Centre, Texas A and M University, 1095 Nuclear Science RD, College Station, Texas 77843 (United States); Reece, W. Daniel [Nuclear Engineering Department, Texas A and M University, College Station, Texas 77843 (United States)

    2010-07-01

    The potential of distance education/learning to deliver knowledge to learners outside the classroom is increasing dramatically as the technologies evolve. Through the past seven years at Texas A and M University Nuclear Science Centre, media-rich distance learning modules of lectures has been developed using the cutting edge technology available. Accordingly, the framework of modularised distance education modules has been established as well. Each module, closed caption enabled, consists of short interactive videos with animations and quizzes embedded. Those individual videos can be regrouped to form a new module depending on the contents of the lecture. The framework of this system was explained and the procedures of creating those modules were detailed. Different deployment methodologies of those modules were also discussed. (authors)

  1. Development and deployment of innovative distance education modules

    International Nuclear Information System (INIS)

    Hsu, Wen-Hsing; Reece, W. Daniel

    2010-01-01

    The potential of distance education/learning to deliver knowledge to learners outside the classroom is increasing dramatically as the technologies evolve. Through the past seven years at Texas A and M University Nuclear Science Centre, media-rich distance learning modules of lectures has been developed using the cutting edge technology available. Accordingly, the framework of modularised distance education modules has been established as well. Each module, closed caption enabled, consists of short interactive videos with animations and quizzes embedded. Those individual videos can be regrouped to form a new module depending on the contents of the lecture. The framework of this system was explained and the procedures of creating those modules were detailed. Different deployment methodologies of those modules were also discussed. (authors)

  2. Developing the impact testing module with labVIEW

    International Nuclear Information System (INIS)

    Choi, Ki Soo; Jeon, Soo Hong; Jeong, Weui Bong

    2007-01-01

    Fast Fourier Transformation (FFT) is one of the most useful way to analyze response signal for the purpose of grasping the dynamic characteristics of system. Vibration test using impact hammer is typical and simple experimental method widely used for catching hold of dynamic peculiar characters and modal behaviors of system. In this thesis, impact testing module for NI-PXI equipment is developed. The analyzing and visualizing module are developed with labVIEW tool. A user can see quickly and easily modal shape of system after analyzing acquired data. This developed module will be expected to build up more convenient and serviceable measurement system

  3. Development of PSA module for computerized accident management support (CAMS)

    International Nuclear Information System (INIS)

    Iguchi, Yukihiro

    1996-10-01

    CAMS (Computerised Accident Management Support) is a system that will provide assistance in case of the accidents in a nuclear power plant. The PSA module was developed in order to give useful information in this situation applying the PSA method, which is a comprehensive source of safety knowledge. This module contains plant-specific PSA data, comprising event trees, failure probabilities etc. It has several event trees categorised according to the initiating events. Each event tree has an initiating event frequency and branching probabilities. The various support systems for branches are considered and their dependencies are calculated logically. This module can be activated by data from the state identification (SI) module of CAMS. If an initiating event occurs, the event tree is re-calculated and the PSA module shows which systems of the plant should be activated to bring the plant to a safe state. If the plant responds to the event in the normal way, the plant will be shut down and come to a safe state. However, if some functions do not work, the PSA module generates another path and gives information about the critical systems. If the state of the plant is changed, either by the operators or automatically by the control system, the PSA module follows the new path. Because the estimation of the core damage frequency should be very quick in the accident situation, a simplified model of the event tree and fault trees was adopted. It enabled the PSA module to calculates the CDF within 5 seconds on a standard type work station. The development of the module has been successful. However, further development of the functionality of the module is suggested like real connection to a plant and to the strategy generator module of CAMS, applications for operational support, low power operation optimisation, etc. (author)

  4. Development of training modules for magnetic particle inspection

    Science.gov (United States)

    Kosaka, Daigo; Eisenmann, David J.; Enyart, Darrel; Nakagawa, Norio; Lo, Chester; Orman, David

    2015-03-01

    Magnetic particle inspection (MPI) is a nondestructive evaluation technique used with ferromagnetic materials. Although the application of this method may appear straightforward, MPI combines the complicated nature of electromagnetics, metallurgical material effects, fluid-particle motion dynamics, and physiological human factors into a single inspection. To fully appreciate industry specifications such as ASTM E-1444, users should develop a basic understanding of the many factors that are involved in MPI. We have developed a series of MPI training modules that are aimed at addressing this requirement. The modules not only offer qualitative explanations, but also show quantitative explanations in terms of measurement and numerical simulation data in many instances. There are five modules in all. Module ♯1 shows characteristics of waveforms and magnetizing methods. This allows MPI practitioners to make optimum choice of waveform and magnetizing method. Module ♯2 explains how material properties relate to the magnetic characteristics. Module ♯3 shows the strength of the excitation field or the flux leakage from a crack and how it compares to the detectability of a crack by MPI. Module ♯4 shows how specimen status may influence defect detection. Module ♯5 shows the effects of particle properties on defect detection.

  5. Modulational instability development and current drive

    International Nuclear Information System (INIS)

    Popel, S.I.; Vladimirov, S.V.; Tsytovich, V.N.

    1992-01-01

    Recently many investigations on current driven by lower-hybrid (LH) waves in a plasma of toroidal nuclear fusion installations are carried out. Usually a theoretical approach taking into account quasilinear and binary collisions effects is used to describe current drive. However a problem of comparison of the results obtained with the aid of the above theoretical approach and experimental data takes place. Namely the experimentally observed currents driven by LH waves is two-three orders of magnitude larger than those calculated. The above discrepancy between theory and experiment is related with the existence of the so-called ''spectral gap'', that is the gap between the parallel phase velocities of LH waves ω/k || (where ω, k || are LH wave frequency and a component of wavenumber k parallel to the external magnetic field) which are necessary for effective Landau damping of LH waves (i.e. velocities as high as several electron thermal velocities) and the lowest parallel phase velocity in the injected LH wave spectrum. Experimentally observed current drive may be explained if one accounts for filling of the ''spectral gap'' by LH waves. Some nonlinear effects have been drawn in current drive description to explain the ''spectral gap'' filling by LH waves. However the LH wave modulational instability (MI) effect has not been considered yet in application to current drive description. The aim of this paper is to investigate this MI influence. We shall show that for sufficiently intensive pump level of LH wave the MI can lead to ''spectral gap'' filling. (author) 4 refs

  6. Inflatable Module Seal Interface Development and Testing

    Data.gov (United States)

    National Aeronautics and Space Administration — Develop a repeatable low permeable sealing interface evaluating O-ring, RTV bond and flowed RTV bond methods. Advanced Bladder materials (ArmorFlex, Nanoclay, etc)...

  7. Orion European Service Module (ESM) Development, Integration and Qualification Status

    Science.gov (United States)

    Berthe, Philippe; Over, Ann P.; Picardo, Michelle; Byers, Anthony W.

    2017-01-01

    ESA and the European Industry are supplying the European Service Module for Orion. An overview of the system and subsystem configuration of the Orion European Service Module (ESM) as designed and built for the EM-1 mission is provided as well as an outline of its development, assembly, integration and verification process performed by ESA and NASA in coordination with their respective Industrial prime contractors, Airbus Defence and Space and Lockheed Martin.

  8. Outsourcing R&D Modules of a New Developing Technology

    DEFF Research Database (Denmark)

    Pedersen, Jørgen Lindgaard; Perunovic, Zoran

    2004-01-01

    The paper explores some of the dimensions of the R&D processes: modularity, uncertainty and outsourcing. Ways to divide R&D effort into modules and to argue, either in direction of its modularity, or interdependency, are presented. Further on, uncertainties are segmented into the majors and minors......, and reasons to outsource R&D modules, in the light of these uncertainties, have been investigated. The R&D process has been observed from insulin technologies development over time....

  9. HELIAS module development for systems codes

    Energy Technology Data Exchange (ETDEWEB)

    Warmer, F., E-mail: Felix.Warmer@ipp.mpg.de; Beidler, C.D.; Dinklage, A.; Egorov, K.; Feng, Y.; Geiger, J.; Schauer, F.; Turkin, Y.; Wolf, R.; Xanthopoulos, P.

    2015-02-15

    In order to study and design next-step fusion devices such as DEMO, comprehensive systems codes are commonly employed. In this work HELIAS-specific models are proposed which are designed to be compatible with systems codes. The subsequently developed models include: a geometry model based on Fourier coefficients which can represent the complex 3-D plasma shape, a basic island divertor model which assumes diffusive cross-field transport and high radiation at the X-point, and a coil model which combines scaling aspects based on the HELIAS 5-B reactor design in combination with analytic inductance and field calculations. In addition, stellarator-specific plasma transport is discussed. A strategy is proposed which employs a predictive confinement time scaling derived from 1-D neoclassical and 3-D turbulence simulations. This paper reports on the progress of the development of the stellarator-specific models while an implementation and verification study within an existing systems code will be presented in a separate work. This approach is investigated to ultimately allow one to conduct stellarator system studies, develop design points of HELIAS burning plasma devices, and to facilitate a direct comparison between tokamak and stellarator DEMO and power plant designs.

  10. Classroom Modules for Nanotechnology Undergraduate Education: Development, Implementation and Evaluation

    Science.gov (United States)

    Shabani, R.; Massi, L.; Zhai, L.; Seal, S.; Cho, H. J.

    2011-01-01

    In order to address the challenges and restrictions given by a traditional classroom lecture environment, the top-down and bottom-up nanotechnology teaching modules were developed, implemented and evaluated. Then based on the hypothesis that instructors could further develop students' interest in this emerging area through the introduction of the…

  11. Development of Scientific Approach Based on Discovery Learning Module

    Science.gov (United States)

    Ellizar, E.; Hardeli, H.; Beltris, S.; Suharni, R.

    2018-04-01

    Scientific Approach is a learning process, designed to make the students actively construct their own knowledge through stages of scientific method. The scientific approach in learning process can be done by using learning modules. One of the learning model is discovery based learning. Discovery learning is a learning model for the valuable things in learning through various activities, such as observation, experience, and reasoning. In fact, the students’ activity to construct their own knowledge were not optimal. It’s because the available learning modules were not in line with the scientific approach. The purpose of this study was to develop a scientific approach discovery based learning module on Acid Based, also on electrolyte and non-electrolyte solution. The developing process of this chemistry modules use the Plomp Model with three main stages. The stages are preliminary research, prototyping stage, and the assessment stage. The subject of this research was the 10th and 11th Grade of Senior High School students (SMAN 2 Padang). Validation were tested by the experts of Chemistry lecturers and teachers. Practicality of these modules had been tested through questionnaire. The effectiveness had been tested through experimental procedure by comparing student achievement between experiment and control groups. Based on the findings, it can be concluded that the developed scientific approach discovery based learning module significantly improve the students’ learning in Acid-based and Electrolyte solution. The result of the data analysis indicated that the chemistry module was valid in content, construct, and presentation. Chemistry module also has a good practicality level and also accordance with the available time. This chemistry module was also effective, because it can help the students to understand the content of the learning material. That’s proved by the result of learning student. Based on the result can conclude that chemistry module based on

  12. Development of the integrated system reliability analysis code MODULE

    International Nuclear Information System (INIS)

    Han, S.H.; Yoo, K.J.; Kim, T.W.

    1987-01-01

    The major components in a system reliability analysis are the determination of cut sets, importance measure, and uncertainty analysis. Various computer codes have been used for these purposes. For example, SETS and FTAP are used to determine cut sets; Importance for importance calculations; and Sample, CONINT, and MOCUP for uncertainty analysis. There have been problems when the codes run each other and the input and output are not linked, which could result in errors when preparing input for each code. The code MODULE was developed to carry out the above calculations simultaneously without linking input and outputs to other codes. MODULE can also prepare input for SETS for the case of a large fault tree that cannot be handled by MODULE. The flow diagram of the MODULE code is shown. To verify the MODULE code, two examples are selected and the results and computation times are compared with those of SETS, FTAP, CONINT, and MOCUP on both Cyber 170-875 and IBM PC/AT. Two examples are fault trees of the auxiliary feedwater system (AFWS) of Korea Nuclear Units (KNU)-1 and -2, which have 54 gates and 115 events, 39 gates and 92 events, respectively. The MODULE code has the advantage that it can calculate the cut sets, importances, and uncertainties in a single run with little increase in computing time over other codes and that it can be used in personal computers

  13. Development of a Flipped Medical School Dermatology Module.

    Science.gov (United States)

    Fox, Joshua; Faber, David; Pikarsky, Solomon; Zhang, Chi; Riley, Richard; Mechaber, Alex; O'Connell, Mark; Kirsner, Robert S

    2017-05-01

    The flipped classroom module incorporates independent study in advance of in-class instructional sessions. It is unproven whether this methodology is effective within a medical school second-year organ system module. We report the development, implementation, and effectiveness of the flipped classroom methodology in a second-year medical student dermatology module at the University of Miami Leonard M. Miller School of Medicine. In a retrospective cohort analysis, we compared attitudinal survey data and mean scores for a 50-item multiple-choice final examination of the second-year medical students who participated in this 1-week flipped course with those of the previous year's traditional, lecture-based course. Each group comprised nearly 200 students. Students' age, sex, Medical College Admission Test scores, and undergraduate grade point averages were comparable between the flipped and traditional classroom students. The flipped module students' mean final examination score of 92.71% ± 5.03% was greater than that of the traditional module students' 90.92% ± 5.51% ( P flipped methodology to attending live lectures or watching previously recorded lectures. The flipped classroom can be an effective instructional methodology for a medical school second-year organ system module.

  14. Development of photovoltaic array and module safety requirements

    Science.gov (United States)

    1982-01-01

    Safety requirements for photovoltaic module and panel designs and configurations likely to be used in residential, intermediate, and large-scale applications were identified and developed. The National Electrical Code and Building Codes were reviewed with respect to present provisions which may be considered to affect the design of photovoltaic modules. Limited testing, primarily in the roof fire resistance field was conducted. Additional studies and further investigations led to the development of a proposed standard for safety for flat-plate photovoltaic modules and panels. Additional work covered the initial investigation of conceptual approaches and temporary deployment, for concept verification purposes, of a differential dc ground-fault detection circuit suitable as a part of a photovoltaic array safety system.

  15. Equipment development for automated assembly of solar modules

    Science.gov (United States)

    Hagerty, J. J.

    1982-01-01

    Prototype equipment was developed which allows for totally automated assembly in the three major areas of module manufacture: cell stringing, encapsulant layup and cure and edge sealing. The equipment is designed to be used in conjunction with a standard Unimate 2000B industrial robot although the design is adaptable to other transport systems.

  16. DEVELOPMENT OF VACUUM SUBLIMATION DRYERS USING THERMOELECTRIC MODULES

    Directory of Open Access Journals (Sweden)

    R. A. Barykin

    2014-01-01

    Full Text Available Summary. The main directions of use of freeze-dryed products and ingredients are revealed. The analysis of sales markets of freeze-dryed products is provided. It is shown that introduction of innovative production technologies will allow to develop dynamically not only to the large companies, but also small firms that will create prerequisites for growth of the Russian market of freeze-dryed products. Tendencies of development of the freeze-drying equipment are analysed. Relevance of development of energy saving freeze-dryers is proved The integrated approach to creation of competitive domestic technologies and the equipment for sublimation dehydration of thermolabile products consists in use of the effective combined remedies of a power supply, a process intensification, reduction of specific energy consumption and, as a result, decrease in product cost at achievement of high quality indicators. Advantages of thermoelectric modules as alternative direction to existing vapor-compression and absorbing refrigerating appliances are given. Researches of process of freeze-drying dehydration with use of thermoelectric modules are conducted. It is scientifically confirmed, that the thermoelectric module working at Peltier effect, promotes increase in refrigerating capacity due to use of the principle of the thermal pump. Options of use of thermoelectric modules in designs of dryers are offered. Optimum operating modes and number of modules in section are defined. Ways of increase of power efficiency of freeze-dryers with use of thermoelectric modules are specified. The received results will allow to make engineering calculations and design of progressive freeze-drying installations with various ways of a power supply.

  17. Development of bouncer-type pulse modulator for the ILC

    International Nuclear Information System (INIS)

    Akemoto, Mitsuo; Honma, Hiroyuki; Nakajima, Hiromitsu; Shidara, Tetsuo; Fukuda, Shigeki

    2009-01-01

    This paper describes a long-pulse 1.3 GHz klystron modulator that was recently developed for the Superconducting RF Test Facility (STF) at High Energy Accelerator Research Organization (KEK). The modulator has a direct-switched-type design with a 1:15 step-up transformer and a bouncer circuit to compensate the output phase droop within ±0.5%; it can drive a klystron up to 10 MW peak power, 1.5 ms rf pulse width, and 5 pps repetition rate. The main features of this modulator are four 50 kW switching power supplies in parallel to charge storage capacitors to 10 kV, self-healing-type storage capacitors to realize a compact capacitor bank, and a highly reliable IGBT switch which enables elimination of a crowbar circuit. Design considerations and its performance are presented. An IEGT (Injection Enhanced Gate Transistor) switch, composed of six series devices with a rating of 4.5 kV and 2100 A-DC, has been also developed and tested for R and D to realize a compact modulator. (author)

  18. Development of modulators against degenerative aging using radiation fusion technology

    Energy Technology Data Exchange (ETDEWEB)

    Jo, S. K.; Park, H. R.; Jang, B. S.; Roh, C. H.; Eom, H. S.; Choi, N. H.; Seol, M. A.; Kim, S. H.; Choi, H. M.; Park, M. K.; Shin, H. J.; Ryu, D. K.; Oh, W. J.; Kim, S. H; Yee, S. T.

    2012-04-15

    1. Objectives Establishment of modelling of degenerative aging using radiation technology Development of aging modulators using radiation degenerative aging model 2. Project results Establishment of the modeling of degenerative aging using radiation technology - The systematic study on the comparison of radiation-induced degeneration and natural aging process in animals and cells confirmed the biological similarity between these two degeneration models - The effective biomarkers were selected for the modelling of degenerative aging using radiation (10 biomarkers for immune/hematopoiesis, 1 for oxidative stress, 6 for molecular signaling, 3 for lipid metabolism) - The optimal irradiation condition was established for the modelling of degerative aging (total 5Gy with fractionation by over 10 times, lapse of over 4 months) - The molecular mechanisms of radiation-induced degeneration were studied including chronic inflammation (lung), inflammation-related lipid metabolism disturbance, mitochondria biogenesis and dynamics - The radiation degenerative model was evaluated with previously known natural substances (resveratrol, EGCG, etc) Development of aging modulators using radiation degenerative aging model - After the screening of about 800 natural herb extracts, 5 effective substances were selected for aging modulation. - 3 candidate compositions were selected from 20 compositions made from effective substances by in vitro evaluation (WAH2, WAH6, WAH7) - 1 composition (WAH6) was selected as the best aging modulator by in vivo evaluation in radiation-induced aging models and degenerative disease models. 3. Expected benefits and plan of application The modelling of degenerative aging using radiation can facilitate the aging research by providing the useful cell/animal models for aging research A large economic benefits are expected by the commercialization of developed aging modulators (over 10 billion KW in 2015.

  19. Developing a servicelearning module for oral health: A needs assessment

    Directory of Open Access Journals (Sweden)

    R Ebrahim

    2017-03-01

    Full Text Available Background. Service learning (SL as a pedagogy in higher education must be differentiated from other services with a primarily philanthropic intent. Dental therapy and oral hygiene students at Sefako Makgatho Health Sciences University, School of Oral Health Sciences, Pretoria, South Africa visit community sites during their 2nd year of study. However, the current curricula would need restructuring for alignment with the espoused pedagogy and standards of SL. Such an SL curriculum design would thus allow for the provision of meaningful services to communities as an integral component of these programmes.Objective. To explore (i perceptions of 2nd-year oral health students; and (ii opinions of academics with regard to the need for an SL module.Methods. Purposive sampling was used to conduct two focus group discussions with academics involved in curriculum development (n=11 and students who had previous exposure to communities (n=10. A survey containing open-ended questions was completed by 9 academics, who would implement the proposed SL module. Frequencies were calculated and data from the open questions were analysed for emergent themes.Results. Most academics (89%, n=8 indicated that working effectively with others as members of a team and developing cultural sensitivity were achievable from an SL module. Two themes emerged from the focus groups, i.e. (i enhanced teaching and learning – students could apply theoretical and clinical training in an authentic setting; and (ii standardisation of training – an SL module would ensure consistency when engaging with communities.Conclusion. The needs assessment was valuable to inform the development and implementation of the SL module.

  20. Development of modulators against degenerative aging using radiation fusion technology

    International Nuclear Information System (INIS)

    Jo, S. K.; Park, H. R.; Jang, B. S.; Roh, C. H.; Eom, H. S.; Choi, N. H.; Seol, M. A.; Kim, S. H.; Choi, H. M.; Park, M. K.; Shin, H. J.; Ryu, D. K.; Oh, W. J.; Kim, S. H; Yee, S. T.

    2012-04-01

    1. Objectives Establishment of modelling of degenerative aging using radiation technology Development of aging modulators using radiation degenerative aging model 2. Project results Establishment of the modeling of degenerative aging using radiation technology - The systematic study on the comparison of radiation-induced degeneration and natural aging process in animals and cells confirmed the biological similarity between these two degeneration models - The effective biomarkers were selected for the modelling of degenerative aging using radiation (10 biomarkers for immune/hematopoiesis, 1 for oxidative stress, 6 for molecular signaling, 3 for lipid metabolism) - The optimal irradiation condition was established for the modelling of degerative aging (total 5Gy with fractionation by over 10 times, lapse of over 4 months) - The molecular mechanisms of radiation-induced degeneration were studied including chronic inflammation (lung), inflammation-related lipid metabolism disturbance, mitochondria biogenesis and dynamics - The radiation degenerative model was evaluated with previously known natural substances (resveratrol, EGCG, etc) Development of aging modulators using radiation degenerative aging model - After the screening of about 800 natural herb extracts, 5 effective substances were selected for aging modulation. - 3 candidate compositions were selected from 20 compositions made from effective substances by in vitro evaluation (WAH2, WAH6, WAH7) - 1 composition (WAH6) was selected as the best aging modulator by in vivo evaluation in radiation-induced aging models and degenerative disease models. 3. Expected benefits and plan of application The modelling of degenerative aging using radiation can facilitate the aging research by providing the useful cell/animal models for aging research A large economic benefits are expected by the commercialization of developed aging modulators (over 10 billion KW in 2015

  1. Development of ultracapacitor modules for 42-V automotive electrical systems

    Science.gov (United States)

    Jung, Do Yang; Kim, Young Ho; Kim, Sun Wook; Lee, Suck-Hyun

    Two types of ultracapacitor modules have been developed for use as energy-storage devices for 42-V systems in automobiles. The modules show high performance and good reliability in terms of discharge and recharge capability, long-term endurance, and high energy and power. During a 42-V system simulation test of 6-kW power boosting/regenerative braking, the modules demonstrate very good performance. In high-power applications such as 42-V and hybrid vehicle systems, ultracapacitors have many merits compared with batteries, especially with respect to specific power at high rate, thermal stability, charge-discharge efficiency, and cycle-life. Ultracapacitors are also very safe, reliable and environmentally friendly. The cost of ultracapacitors is still high compared with batteries because of the low production scale, but is decreasing very rapidly. It is estimated that the cost of ultracapacitors will decrease to US$ 300 per 42-V module in the near future. Also, the maintenance cost of the ultracapacitor is nearly zero because of its high cycle-life. Therefore, the combined cost of the capacitor and maintenance will be lower than that of batteries in the near future. Overall, comparing performance, price and other parameters of ultracapacitors with batteries, ultracapacitors are the most likely candidate for energy-storage in 42-V systems.

  2. Developing Media Module Proposed to Editor in Editorial Division

    Science.gov (United States)

    Kristanto, A.; Mustaji; Mariono, A.; Sulistiowati; Nuryati, D. W.

    2018-01-01

    In this era of technology in Indonesia, various publishers introduce themselves and participate in advancing the quality of education through the publication of various books as the learning sources. One of the publishers is PT. JP Press. In compiling the learning sources, we found some problems that are left unresolved by the editor. The purpose of this research is to overcome the problems that exist in PT. JP Press by developing media module. This development research uses the ADDIE model. The types of data used in this study are qualitative and quantitative data obtained based on the results of structured interviews with material experts and media experts, as well as the editorial response questionnaire provided for individual try-out and small group try-out. Therefore, it can be concluded that the medium of elementary school supplementary module proposed to the editors of PT. JP Press is valuable to be used in the teaching and learning activities.

  3. Development of Nanosatellite Technology with APRS Module for Disaster Mitigation

    Science.gov (United States)

    Prahyang, S. Y.; Dhiya’Ulhaq, M. Z.; Golim, O. P.; Gunawan, R.; Suhandinata; Jahja, E.; Nelwan, E. R. G.; Ananta, C.; Chow, I. M.; Mali, N. D. F.

    2018-05-01

    Development of nanosatellite technology has enabled satellites to be developed with multiple capabilities for a specific mission in a short time with a low cost. Satellite communications are proved to be more effective in delivering information due to its large coverage area. Surya Satellite-1 will become the first Indonesian nanosatellite developed by undergraduate students. It is designed with low-cost commercial payloads, including an APRS module for communication and operated on VHF and UHF amateur radio frequencies. The mission of the satellites focused on disaster mitigation through APRS communication network with remote stations located on disaster-prone areas.

  4. Development of severe accident guidance module for the SATS simulator

    International Nuclear Information System (INIS)

    Kim, K.R.; Park, S.H.; Kim, D.H.; Song, Y.M.

    2004-01-01

    Recently KAERI has developed the severe accident management guidance to establish Korea standard severe accident management system. On the other hand the PC-based severe accident training simulator SATS has been developed, which uses MELCOR code as the simulation engine. SATS graphically displays and simulates the severe accidents with interactive user commands. The control capability of SATS could make severe accident training course more interesting and effective. In this paper we will describe the development and functions of the electrical hypertext guidance module HyperKAMG and the SATS-HyperKAMG linkage system for the severe accident management. (author)

  5. Development of the module inspection system for new standardized radiation monitoring modules

    International Nuclear Information System (INIS)

    Furukawa, Masami; Shimizu, Kazuaki; Hiruta, Toshihito; Mizugaki, Toshio; Ohi, Yoshihiro; Chida, Tooru.

    1994-10-01

    This report mentions about the module inspection system which does the maintenance check of the monitoring modules adapted the new monitoring standard, as well as the result of the verification of the modules. The module inspection system is the automatic measurement system with the computer. The system can perform the functional and the characteristic examination of the monitoring modules, the calibration with radiation source and inspection report. In the verification of the monitoring module, three major items were tested, the adaptability for the new monitoring standard, the module functions and each characteristics. All items met the new monitoring standard. (author)

  6. Development of DKB ETL module in case of data conversion

    Science.gov (United States)

    Kaida, A. Y.; Golosova, M. V.; Grigorieva, M. A.; Gubin, M. Y.

    2018-05-01

    Modern scientific experiments involve the producing of huge volumes of data that requires new approaches in data processing and storage. These data themselves, as well as their processing and storage, are accompanied by a valuable amount of additional information, called metadata, distributed over multiple informational systems and repositories, and having a complicated, heterogeneous structure. Gathering these metadata for experiments in the field of high energy nuclear physics (HENP) is a complex issue, requiring the quest for solutions outside the box. One of the tasks is to integrate metadata from different repositories into some kind of a central storage. During the integration process, metadata taken from original source repositories go through several processing steps: metadata aggregation, transformation according to the current data model and loading it to the general storage in a standardized form. The R&D project of ATLAS experiment on LHC, Data Knowledge Base, is aimed to provide fast and easy access to significant information about LHC experiments for the scientific community. The data integration subsystem, being developed for the DKB project, can be represented as a number of particular pipelines, arranging data flow from data sources to the main DKB storage. The data transformation process, represented by a single pipeline, can be considered as a number of successive data transformation steps, where each step is implemented as an individual program module. This article outlines the specifics of program modules, used in the dataflow, and describes one of the modules developed and integrated into the data integration subsystem of DKB.

  7. Development of a Precise Polarization Modulator for UV Spectropolarimetry

    Science.gov (United States)

    Ishikawa, S.; Shimizu, T.; Kano, R.; Bando, T.; Ishikawa, R.; Giono, G.; Tsuneta, S.; Nakayama, S.; Tajima, T.

    2015-10-01

    We developed a polarization modulation unit (PMU) to rotate a waveplate continuously in order to observe solar magnetic fields by spectropolarimetry. The non-uniformity of the PMU rotation may cause errors in the measurement of the degree of linear polarization (scale error) and its angle (crosstalk between Stokes-Q and -U), although it does not cause an artificial linear polarization signal (spurious polarization). We rotated a waveplate with the PMU to obtain a polarization modulation curve and estimated the scale error and crosstalk caused by the rotation non-uniformity. The estimated scale error and crosstalk were {PMU will be used as a waveplate motor for the Chromospheric Lyman-Alpha SpectroPolarimeter (CLASP) rocket experiment. We confirm that the PMU performs and functions sufficiently well for CLASP.

  8. Retinoic acid modulates chondrogenesis in the developing mouse cranial base.

    Science.gov (United States)

    Kwon, Hyuk-Jae; Shin, Jeong-Oh; Lee, Jong-Min; Cho, Kyoung-Won; Lee, Min-Jung; Cho, Sung-Won; Jung, Han-Sung

    2011-12-15

    The retinoic acid (RA) signaling pathway is known to play important roles during craniofacial development and skeletogenesis. However, the specific mechanism involving RA in cranial base development has not yet been clearly described. This study investigated how RA modulates endochondral bone development of the cranial base by monitoring the RA receptor RARγ, BMP4, and markers of proliferation, programmed cell death, chondrogenesis, and osteogenesis. We first examined the dynamic morphological and molecular changes in the sphenooccipital synchondrosis-forming region in the mouse embryo cranial bases at E12-E16. In vitro organ cultures employing beads soaked in RA and retinoid-signaling inhibitor citral were compared. In the RA study, the sphenooccipital synchondrosis showed reduced cartilage matrix and lower BMP4 expression while hypertrophic chondrocytes were replaced with proliferating chondrocytes. Retardation of chondrocyte hypertrophy was exhibited in citral-treated specimens, while BMP4 expression was slightly increased and programmed cell death was induced within the sphenooccipital synchondrosis. Our results demonstrate that RA modulates chondrocytes to proliferate, differentiate, or undergo programmed cell death during endochondral bone formation in the developing cranial base. Copyright © 2011 Wiley Periodicals, Inc., A Wiley Company.

  9. Photovoltaic module certification/laboratory accreditation criteria development

    Energy Technology Data Exchange (ETDEWEB)

    Osterwald, C.R. [National Renewable Energy Lab., Golden, CO (United States); Hammond, R.L.; Wood, B.D.; Backus, C.E.; Sears, R.L. [Arizona State Univ., Tempe, AZ (United States); Zerlaut, G.A. [SC-International Inc., Phoenix, AZ (United States); D`Aiello, R.V. [RD Associates, Tempe, AZ (United States)

    1995-04-01

    This document provides an overview of the structure and function of typical product certification/laboratory accreditation programs. The overview is followed by a model program which could serve as the basis for a photovoltaic (PV) module certification/laboratory accreditation program. The model covers quality assurance procedures for the testing laboratory and manufacturer, third-party certification and labeling, and testing requirements (performance and reliability). A 30-member Criteria Development Committee was established to guide, review, and reach a majority consensus regarding criteria for a PV certification/laboratory accreditation program. Committee members represented PV manufacturers, end users, standards and codes organizations, and testing laboratories.

  10. Intensity Modulated Radiation Therapy. Development of the technique

    International Nuclear Information System (INIS)

    Rafailovici, L.; Alva, R.; Chiozza, J.; Donato, H.; Falomo, S.; Cardiello, C.; Furia, O.; Martinez, A.; Filomia, M.L.; Sansogne, R.; Arbiser, S.; Dosoretz, B.

    2008-01-01

    Full text: Introduction: Intensity Modulated Radiation Therapy (IMRT) is a result of advances in computer sciences that allowed the development of new technology related to planning and radiation therapy. IMRT was developed to homogenize the dose in the target volumes and decrease the dose in the surrounding healthy tissue. Using a software with high calculation capacity a simultaneous irradiation with different doses in a given volume is achieved. IMRT is based on internal planning. Material and methods: 628 patients were treated with IMRT in prostate lesions, head and neck, breast, thorax, abdomen and brain since August 2008. The software for IMRT is the XIO CMS and the accelerator used is a Varian Clinac 6 / 100. IMRT requires a first simulation, where immobilization systems are selected (mats, thermoplastic masks, among others) and the demarcation of the target structures, healthy tissue and dose prescription by a tattoo. Images of CT / MRI are merged when necessary. Once the system made the treatment optimization, this one is regulated by modulators. These are produced by numerical control machines from digital files produced by software. In a second modulation the planned irradiation is checked and tattoo is carried out according with this. We have a strict process of quality assurance to assess the viability of the plan before its implementation. We use the Map Check it possible to compare the dose on the central axis and the distribution in the whole plane regarding to that generated by the planning system. From 03/2008 the virtual simulation process was implemented integrating the described stages. Results and Conclusions: IMRT is a complex technique. The meticulous planning, implementation of process and quality control allows the use of this technique in a reliable and secure way. With IMRT we achieved a high level of dose conformation, less irradiation of healthy tissue, lower rates of complications and the dose escalation for some tumors. (authors) [es

  11. Seed-vectored endophytic bacteria modulate development of rice seedlings.

    Science.gov (United States)

    Verma, S K; Kingsley, K; Irizarry, I; Bergen, M; Kharwar, R N; White, J F

    2017-06-01

    The aim of the present study was to evaluate the effects of the removal of indigenous bacteria from rice seeds on seedling growth and development. Here we report the presence of three indigenous endophytic bacteria in rice seeds that play important roles in modulating seedling development (shoot and root lengths, and formation of root hairs and secondary roots) and defence against pathogens. Seed-associated bacteria were removed using surface sterilization with NaOCl (bleach) followed by antibiotic treatment. When bacteria were absent, growth of seedlings in terms of root hair development and overall seedling size was less than that of seedlings that contained bacteria. Reactive oxygen staining of seedlings showed that endophytic bacteria became intracellular in root parenchyma cells and root hairs. Roots containing endophytic bacteria were seen to stain densely for reactive oxygen, while roots free of bacteria stained lightly for reactive oxygen. Bacteria were isolated and identified as Enterobacter asburiae (VWB1), Pantoea dispersa (VWB2) and Pseudomonas putida (VWB3) by 16S rDNA sequencing. Bacteria were found to produce indole acetic acid (auxins), inhibited the pathogen Fusarium oxysporum and solubilized phosphate. Reinoculation of bacteria onto seedlings derived from surface-disinfected rice and Bermuda grass seeds significantly restored seedling growth and development. Rice seeds harbour indigenous bacterial endophytes that greatly influence seedling growth and development, including root and shoot lengths, root hair formation and disease susceptibility of rice seedlings. This study shows that seeds of rice naturally harbour bacterial endophytes that play key roles in modulation of seedling development. © 2017 The Society for Applied Microbiology.

  12. Revised upper limb module for spinal muscular atrophy: Development of a new module.

    Science.gov (United States)

    Mazzone, Elena S; Mayhew, Anna; Montes, Jacqueline; Ramsey, Danielle; Fanelli, Lavinia; Young, Sally Dunaway; Salazar, Rachel; De Sanctis, Roberto; Pasternak, Amy; Glanzman, Allan; Coratti, Giorgia; Civitello, Matthew; Forcina, Nicola; Gee, Richard; Duong, Tina; Pane, Marika; Scoto, Mariacristina; Pera, Maria Carmela; Messina, Sonia; Tennekoon, Gihan; Day, John W; Darras, Basil T; De Vivo, Darryl C; Finkel, Richard; Muntoni, Francesco; Mercuri, Eugenio

    2017-06-01

    There is a growing need for a robust clinical measure to assess upper limb motor function in spinal muscular atrophy (SMA), as the available scales lack sensitivity at the extremes of the clinical spectrum. We report the development of the Revised Upper Limb Module (RULM), an assessment specifically designed for upper limb function in SMA patients. An international panel with specific neuromuscular expertise performed a thorough review of scales currently available to assess upper limb function in SMA. This review facilitated a revision of the existing upper limb function scales to make a more robust clinical scale. Multiple revisions of the scale included statistical analysis and captured clinically relevant changes to fulfill requirements by regulators and advocacy groups. The resulting RULM scale shows good reliability and validity, making it a suitable tool to assess upper extremity function in the SMA population for multi-center clinical research. Muscle Nerve 55: 869-874, 2017. © 2016 Wiley Periodicals, Inc.

  13. Packaging Aspects of Photodetector Modules for 100 Gbit/s Ethernet Applications

    DEFF Research Database (Denmark)

    Jiang, Chenhui; Mekonnen, G.G.; Krozer, Viktor

    2008-01-01

    Packaging is a major problem at millimetre-wave frequencies approaching 100 GHz. In this paper we present that insertion losses in a multi-chip module (MCM) can be less IL ...-backed coplanar waveguides (CBCPWs) with vias is accurately analyzed using 3D electromagnetic (EM) simulation over a wide frequency range. Patch antenna mode resonances are identified as a major origin of resonances in simulated and measured transmission characteristics of the CBCPW with vias. Based on EM...

  14. Development and Evaluation of an Undergraduate Science Communication Module

    Science.gov (United States)

    Yeoman, Kay H.; James, Helen A.; Bowater, Laura

    2011-01-01

    This paper describes the design and evaluation of an undergraduate final year science communication module for the Science Faculty at the University of East Anglia. The module focuses specifically on science communication and aims to bring an understanding of how science is disseminated to the public. Students on the module are made aware of the…

  15. Space station common module network topology and hardware development

    Science.gov (United States)

    Anderson, P.; Braunagel, L.; Chwirka, S.; Fishman, M.; Freeman, K.; Eason, D.; Landis, D.; Lech, L.; Martin, J.; Mccorkle, J.

    1990-01-01

    Conceptual space station common module power management and distribution (SSM/PMAD) network layouts and detailed network evaluations were developed. Individual pieces of hardware to be developed for the SSM/PMAD test bed were identified. A technology assessment was developed to identify pieces of equipment requiring development effort. Equipment lists were developed from the previously selected network schematics. Additionally, functional requirements for the network equipment as well as other requirements which affected the suitability of specific items for use on the Space Station Program were identified. Assembly requirements were derived based on the SSM/PMAD developed requirements and on the selected SSM/PMAD network concepts. Basic requirements and simplified design block diagrams are included. DC remote power controllers were successfully integrated into the DC Marshall Space Flight Center breadboard. Two DC remote power controller (RPC) boards experienced mechanical failure of UES 706 stud-mounted diodes during mechanical installation of the boards into the system. These broken diodes caused input to output shorting of the RPC's. The UES 706 diodes were replaced on these RPC's which eliminated the problem. The DC RPC's as existing in the present breadboard configuration do not provide ground fault protection because the RPC was designed to only switch the hot side current. If ground fault protection were to be implemented, it would be necessary to design the system so the RPC switched both the hot and the return sides of power.

  16. Recommendations for the development of e-modules for the continuing professional development of European dentists

    NARCIS (Netherlands)

    Kavadella, A.; Kossioni, A.E.; Tsiklakis, K.; Cowpe, J.; Bullock, A.; Barnes, E.; Bailey, S.; Thomas, H.; Thomas, R.; Karaharju-Suvanto, T.; Suomalainen, K.; Kersten, H.; Povel, E.; Giles, M.; Walmsley, D.; Soboleva, U.; Liepa, A.; Akota, I.

    2013-01-01

    Aims To provide evidence-based and peer-reviewed recommendations for the development of dental continuing professional development (CPD) learning e-modules. Methods The present recommendations are consensus recommendations of the DentCPD project team and were informed by a literature research,

  17. Recommendations for the development of e-modules for the continuing professional development of European dentists.

    Science.gov (United States)

    Kavadella, A; Kossioni, A E; Tsiklakis, K; Cowpe, J; Bullock, A; Barnes, E; Bailey, S; Thomas, H; Thomas, R; Karaharju-Suvanto, T; Suomalainen, K; Kersten, H; Povel, E; Giles, M; Walmsley, D; Soboleva, U; Liepa, A; Akota, I

    2013-05-01

    To provide evidence-based and peer-reviewed recommendations for the development of dental continuing professional development (CPD) learning e-modules. The present recommendations are consensus recommendations of the DentCPD project team and were informed by a literature research, consultations from e-learning and IT expert, discussions amongst the participants attending a special interest group during the 2012 ADEE meeting, and feedback from the evaluation procedures of the exemplar e-module (as described in a companion paper within this Supplement). The main focus of these recommendations is on the courses and modules organised and offered by dental schools. E-modules for dental CPD, as well as for other health professionals' continuing education, have been implemented and evaluated for a number of years. Research shows that the development of e-modules is a team process, undertaken by academics, subject experts, pedagogists, IT and web designers, learning technologists and librarians. The e-module must have clear learning objectives (outcomes), addressing the learners' individual needs, and must be visually attractive, relevant, interactive, promoting critical thinking and providing feedback. The text, graphics and animations must support the objectives and enable the learning process by creating an attractive, easy to navigate and interactive electronic environment. Technology is usually a concern for learners and tutors; therefore, it must be kept simple and interoperable within different systems and software. The pedagogical and technological proficiency of educators is of paramount importance, yet remains a challenge in many instances. The development of e-courses and modules for dental CPD is an endeavour undertaken by a group of professionals. It must be underpinned by sound pedagogical and e-learning principles and must incorporate elements for effective visual learning and visual design and a simple, consistent technology. © 2013 John Wiley & Sons A/S.

  18. Status Report on NEAMS System Analysis Module Development

    Energy Technology Data Exchange (ETDEWEB)

    Hu, R. [Argonne National Lab. (ANL), Argonne, IL (United States); Fanning, T. H. [Argonne National Lab. (ANL), Argonne, IL (United States); Sumner, T. [Argonne National Lab. (ANL), Argonne, IL (United States); Yu, Y. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-12-01

    Under the Reactor Product Line (RPL) of DOE-NE’s Nuclear Energy Advanced Modeling and Simulation (NEAMS) program, an advanced SFR System Analysis Module (SAM) is being developed at Argonne National Laboratory. The goal of the SAM development is to provide fast-running, improved-fidelity, whole-plant transient analyses capabilities. SAM utilizes an object-oriented application framework MOOSE), and its underlying meshing and finite-element library libMesh, as well as linear and non-linear solvers PETSc, to leverage modern advanced software environments and numerical methods. It also incorporates advances in physical and empirical models and seeks closure models based on information from high-fidelity simulations and experiments. This report provides an update on the SAM development, and summarizes the activities performed in FY15 and the first quarter of FY16. The tasks include: (1) implement the support of 2nd-order finite elements in SAM components for improved accuracy and computational efficiency; (2) improve the conjugate heat transfer modeling and develop pseudo 3-D full-core reactor heat transfer capabilities; (3) perform verification and validation tests as well as demonstration simulations; (4) develop the coupling requirements for SAS4A/SASSYS-1 and SAM integration.

  19. Design and development of high voltage MARX modulator technology for long pulse application

    International Nuclear Information System (INIS)

    Acharya, Mahesh; Shrivastava, Purushottam

    2013-01-01

    High power pulse modulators are used for powering the RF amplifier like klystrons. This paper describes the development of a 10 kV, 10 A, 1 ms Marx modulator for technology demonstration. The modulator is developed using four no. of main modules each of 2.5 kV. To reduce the over sizing factor of capacitors, the allowed drop of main Marx cell is 9%. A droop compensation circuit has been developed to reduce the output pulse voltage droop from 9% to within ±1%. Droop compensation consists of 10 numbers of corrector modules each of 200 V. A microcontroller based trigger circuit was used for simultaneous triggering of main modules and for staggered triggering of corrector modules. A 25 kV, 10 A, 1 ms Marx modulator is being developed. The advantages of this scheme are oil free design, low DC voltage, adjustable pulse width, adjustable rise time/fall time and modular design etc. (author)

  20. The development of form two mathematics i-Think module (Mi-T2)

    Science.gov (United States)

    Yao, Foo Jing; Abdullah, Mohd Faizal Nizam Lee; Tien, Lee Tien

    2017-05-01

    This study aims to develop a training module i-THINK Mathematics Form Two (Mi-T2) to increase the higher-order thinking skills of students. The Mi-T2 training module was built based on the Sidek Module Development Model (2001). Constructivist learning theory, cognitive learning theory, i-THINK map and higher order thinking skills were the building blocks of the module development. In this study, researcher determined the validity and reliability of Mi-T2 module. The design being used in this study was descriptive study. To determine the needs of Mi-T2 module, questionnaires and literature review were used to collect data. When the need of the module was determined, the module was built and a pilot study was conducted to test the reliability of the Mi-T2 module. The pilot study was conducted at a secondary school in North Kinta, Perak. A Form Two class was selected to be the sample study through clustered random sampling. The pilot study was conducted for two months and one topic had been studied. The Mi-T2 module was evaluated by five expert panels to determine the content validity of the module. The instruments being used in the study were questionnaires about the necessity of the Mi-T2 module for guidance, questionnaires about the validity of the module and questionnaires concerning the reliability of the module. Statistical analysis was conducted to determine the validity and reliability coefficients of the Mi-T2 module. The content validity of Mi-T2 module was determined by Cohen's Kappa's (1968) agreement coefficient and the reliability of Mi-T2 module was determined by Cronbach Alpha's value scale. The content validity of Mi-T2 module was 0.89 and the Cronbach Alpha's value of Mi-T2 module was 0.911.

  1. Photovoltaic module certification/laboratory accreditation criteria development: Implementation handbook

    Energy Technology Data Exchange (ETDEWEB)

    Osterwald, C.R. [National Renewable Energy Laboratory, Golden, CO (United States); Hammond, R.L.; Wood, B.D.; Backus, C.E.; Sears, R.L. [Arizona State Univ., Tempe, AZ (United States); Zerlaut, G.A. [SC-International, Inc., Tempe, AZ (United States); D`Aiello, R.V. [RD Associates, Tempe, AZ (United States)

    1996-08-01

    This document covers the second phase of a two-part program. Phase I provided an overview of the structure and function of typical product certification/laboratory accreditation programs. This report (Phase H) provides most of the draft documents that will be necessary for the implementation of a photovoltaic (PV) module certification/laboratory accreditation program. These include organizational documents such as articles of incorporation, bylaws, and rules of procedure, as well as marketing and educational program documents. In Phase I, a 30-member criteria development committee was established to guide, review and reach a majority consensus regarding criteria for a PV certification/laboratory accreditation program. Committee members represented PV manufacturers, end users, standards and codes organizations, and testing laboratories. A similar committee was established for Phase II; the criteria implementation committee consisted of 29 members. Twenty-one of the Phase I committee members also served on the Phase II committee, which helped to provide program continuity during Phase II.

  2. Module and electronics developments for the ATLAS ITK pixel system

    CERN Document Server

    Munoz Sanchez, Francisca Javiela; The ATLAS collaboration

    2017-01-01

    The ATLAS experiment is preparing for an extensive modification of its detectors in the course of the planned HL-LHC accelerator upgrade around 2025. The ATLAS upgrade includes the replacement of the entire tracking system by an all-silicon detector (Inner Tracker, ITk). The five innermost layers of ITk will be a pixel detector built of new sensor and readout electronics technologies to improve the tracking performance and cope with the severe HL-LHC environment in terms of occupancy and radiation. The total area of the new pixel system could measure up to 14 m2, depending on the final layout choice, which is expected to take place in 2017. In this paper an overview of the ongoing R\\&D activities on modules and electronics for the ATLAS ITk is given including the main developments and achievements in silicon planar and 3D sensor technologies, readout and power challenges.

  3. Welding techniques development of CLAM steel for Test Blanket Module

    Energy Technology Data Exchange (ETDEWEB)

    Li Chunjing [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui, 230031 (China); School of Nuclear Science and Technology, University of Science and Technology of China, Hefei, Anhui, 230027 (China)], E-mail: lcj@ipp.ac.cn; Huang Qunying; Wu Qingsheng; Liu Shaojun [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui, 230031 (China); School of Nuclear Science and Technology, University of Science and Technology of China, Hefei, Anhui, 230027 (China); Lei Yucheng [Jiangsu University, Zhenjiang, Jiangsu, 212013 (China); Muroga, Takeo; Nagasaka, Takuya [National Institute for Fusion Science, Toki, Jifu, 509-5292 (Japan); Zhang Jianxun [Xi' an Jiaotong University, Xi' an, Shanxi, 710049 (China); Li Jinglong [Northwestern Polytechnical University, Xi' an, Shanxi, 710072 (China)

    2009-06-15

    Fabrication techniques for Test Blanket Module (TBM) with CLAM are being under development. Effect of surface preparation on the HIP diffusion bonding joints was studied and good joints with Charpy impact absorbed energy close to that of base metal have been obtained. The mechanical properties test showed that effect of HIP process on the mechanical properties of base metal was little. Uniaxial diffusion bonding experiments were carried out to study the effect of temperature on microstructure and mechanical properties. And preliminary experiments on Electron Beam Welding (EBW), Tungsten Inert Gas (TIG) Welding and Laser Beam Welding (LBW) were performed to find proper welding techniques to assemble the TBM. In addition, the thermal processes assessed with a Gleeble thermal-mechanical machine were carried out as well to assist the fusion welding research.

  4. Selective androgen receptor modulators in preclinical and clinical development.

    Science.gov (United States)

    Narayanan, Ramesh; Mohler, Michael L; Bohl, Casey E; Miller, Duane D; Dalton, James T

    2008-01-01

    Androgen receptor (AR) plays a critical role in the function of several organs including primary and accessory sexual organs, skeletal muscle, and bone, making it a desirable therapeutic target. Selective androgen receptor modulators (SARMs) bind to the AR and demonstrate osteo- and myo-anabolic activity; however, unlike testosterone and other anabolic steroids, these nonsteroidal agents produce less of a growth effect on prostate and other secondary sexual organs. SARMs provide therapeutic opportunities in a variety of diseases, including muscle wasting associated with burns, cancer, or end-stage renal disease, osteoporosis, frailty, and hypogonadism. This review summarizes the current standing of research and development of SARMs, crystallography of AR with SARMs, plausible mechanisms for their action and the potential therapeutic indications for this emerging class of drugs.

  5. Development of a Unique Small Molecule Modulator of CXCR4

    Science.gov (United States)

    Yoon, Younghyoun; Lin, Songbai; Sasaki, Maiko; Klapproth, Jan-Michael A.; Yang, Hua; Grossniklaus, Hans E.; Xu, Jianguo; Rojas, Mauricio; Voll, Ronald J.; Goodman, Mark M.; Arrendale, Richard F.; Liu, Jin; Yun, C. Chris; Snyder, James P.; Liotta, Dennis C.; Shim, Hyunsuk

    2012-01-01

    Background Metastasis, the spread and growth of tumor cells to distant organ sites, represents the most devastating attribute and plays a major role in the morbidity and mortality of cancer. Inflammation is crucial for malignant tumor transformation and survival. Thus, blocking inflammation is expected to serve as an effective cancer treatment. Among anti-inflammation therapies, chemokine modulation is now beginning to emerge from the pipeline. CXC chemokine receptor-4 (CXCR4) and its ligand stromal cell-derived factor-1 (CXCL12) interaction and the resulting cell signaling cascade have emerged as highly relevant targets since they play pleiotropic roles in metastatic progression. The unique function of CXCR4 is to promote the homing of tumor cells to their microenvironment at the distant organ sites. Methodology/Principal Findings We describe the actions of N,N′-(1,4-phenylenebis(methylene))dipyrimidin-2-amine (designated MSX-122), a novel small molecule and partial CXCR4 antagonist with properties quite unlike that of any other reported CXCR4 antagonists, which was prepared in a single chemical step using a reductive amination reaction. Its specificity toward CXCR4 was tested in a binding affinity assay and a ligand competition assay using 18F-labeled MSX-122. The potency of the compound was determined in two functional assays, Matrigel invasion assay and cAMP modulation. The therapeutic potential of MSX-122 was evaluated in three different murine models for inflammation including an experimental colitis, carrageenan induced paw edema, and bleomycin induced lung fibrosis and three different animal models for metastasis including breast cancer micrometastasis in lung, head and neck cancer metastasis in lung, and uveal melanoma micrometastasis in liver in which CXCR4 was reported to play crucial roles. Conclusions/Significance We developed a novel small molecule, MSX-122, that is a partial CXCR4 antagonist without mobilizing stem cells, which can be safer for

  6. Development of a unique small molecule modulator of CXCR4.

    Directory of Open Access Journals (Sweden)

    Zhongxing Liang

    Full Text Available Metastasis, the spread and growth of tumor cells to distant organ sites, represents the most devastating attribute and plays a major role in the morbidity and mortality of cancer. Inflammation is crucial for malignant tumor transformation and survival. Thus, blocking inflammation is expected to serve as an effective cancer treatment. Among anti-inflammation therapies, chemokine modulation is now beginning to emerge from the pipeline. CXC chemokine receptor-4 (CXCR4 and its ligand stromal cell-derived factor-1 (CXCL12 interaction and the resulting cell signaling cascade have emerged as highly relevant targets since they play pleiotropic roles in metastatic progression. The unique function of CXCR4 is to promote the homing of tumor cells to their microenvironment at the distant organ sites.We describe the actions of N,N'-(1,4-phenylenebis(methylenedipyrimidin-2-amine (designated MSX-122, a novel small molecule and partial CXCR4 antagonist with properties quite unlike that of any other reported CXCR4 antagonists, which was prepared in a single chemical step using a reductive amination reaction. Its specificity toward CXCR4 was tested in a binding affinity assay and a ligand competition assay using (18F-labeled MSX-122. The potency of the compound was determined in two functional assays, Matrigel invasion assay and cAMP modulation. The therapeutic potential of MSX-122 was evaluated in three different murine models for inflammation including an experimental colitis, carrageenan induced paw edema, and bleomycin induced lung fibrosis and three different animal models for metastasis including breast cancer micrometastasis in lung, head and neck cancer metastasis in lung, and uveal melanoma micrometastasis in liver in which CXCR4 was reported to play crucial roles.We developed a novel small molecule, MSX-122, that is a partial CXCR4 antagonist without mobilizing stem cells, which can be safer for long-term blockade of metastasis than other reported CXCR4

  7. Development of Modulators Against Degenerative Aging Using Radiation Fusion Technology

    Energy Technology Data Exchange (ETDEWEB)

    Jo, Sung Kee; Jung, U.; Park, H. R.

    2010-04-15

    In this study, we selected final 20 biomarkers for the degenerative aging to develop radiation aging modeling, and validated a few of selected markers to utilize them in the screening of aging modulators. To select the biomarkers of the degenerative aging, 4 categories of aging-related markers (immune/hematopoiesis, oxidative damage, signaling molecule, lipid metabolism) were comparatively analyzed in irradiated and normally aged biosystems (cell lines or mice). In result, most of the biomarkers showed similar changes by irradiation and normal aging. Regarding the immune/hematopoiesis, the decline of immune cell functions (lymphocyte, NK cell) and Th1/Th2 imbalance, and decreased antigen-presenting of dendritic cells were observed and 10 biomarkers were selected in this category. mtDNA deletion was selected for the oxidative damage marker, 6 biomarkers including p21 and p-FOXO3a for signaling molecule biomarkers, and 3 biomarkers including the adipose tissue weight were selected for lipid metabolism. In addition, the various radiation application conditions by single/factionated irradiation and the periods after the irradiation were investigated for the optimal induction of changes of biomarker, which revealed that total 5Gy of 10 or more fractionated irradiations and 4 months or greather period were observed to be optimal. To found the basis for the screening of natural aging modulators, some selected aging biomarkers were validated by their inhibition by well-known natural agents (EGCG, HemoHIM, etc) in aged cell or mouse model. Additionally, by evaluating the reductive efficacy of 5 natural agents on the degeneration of skin and reproductive organs induced by radiation and chemicals (cyclophosphamide, etc), we established the base for the screening of degenerative diseases by various factors

  8. Development of Modulators Against Degenerative Aging Using Radiation Fusion Technology

    International Nuclear Information System (INIS)

    Jo, Sung Kee; Jung, U.; Park, H. R.

    2010-04-01

    In this study, we selected final 20 biomarkers for the degenerative aging to develop radiation aging modeling, and validated a few of selected markers to utilize them in the screening of aging modulators. To select the biomarkers of the degenerative aging, 4 categories of aging-related markers (immune/hematopoiesis, oxidative damage, signaling molecule, lipid metabolism) were comparatively analyzed in irradiated and normally aged biosystems (cell lines or mice). In result, most of the biomarkers showed similar changes by irradiation and normal aging. Regarding the immune/hematopoiesis, the decline of immune cell functions (lymphocyte, NK cell) and Th1/Th2 imbalance, and decreased antigen-presenting of dendritic cells were observed and 10 biomarkers were selected in this category. mtDNA deletion was selected for the oxidative damage marker, 6 biomarkers including p21 and p-FOXO3a for signaling molecule biomarkers, and 3 biomarkers including the adipose tissue weight were selected for lipid metabolism. In addition, the various radiation application conditions by single/factionated irradiation and the periods after the irradiation were investigated for the optimal induction of changes of biomarker, which revealed that total 5Gy of 10 or more fractionated irradiations and 4 months or greather period were observed to be optimal. To found the basis for the screening of natural aging modulators, some selected aging biomarkers were validated by their inhibition by well-known natural agents (EGCG, HemoHIM, etc) in aged cell or mouse model. Additionally, by evaluating the reductive efficacy of 5 natural agents on the degeneration of skin and reproductive organs induced by radiation and chemicals (cyclophosphamide, etc), we established the base for the screening of degenerative diseases by various factors

  9. Ultra-Wideband Optical Modulation Spectrometer (OMS) Development

    Science.gov (United States)

    Gardner, Jonathan (Technical Monitor); Tolls, Volker

    2004-01-01

    The optical modulation spectrometer (OMS) is a novel, highly efficient, low mass backend for heterodyne receiver systems. Current and future heterodyne receiver systems operating at frequencies up to a few THz require broadband spectrometer backends to achieve spectral resolutions of R approximately 10(exp 5) to 10(exp 6) to carry out many important astronomical investigations. Among these are observations of broad emission and absorption lines from extra-galactic objects at high redshifts, spectral line surveys, and observations of planetary atmospheres. Many of these lines are pressure or velocity broadened with either large half-widths or line wings extending over several GHz. Current backend systems can cover the needed bandwidth only by combining the output of several spectrometers, each with typically up to 1 GHz bandwidth, or by combining several frequency-shifted spectra taken with a single spectrometer. An ultra-wideband optical modulation spectrometer with 10 - 40 GHz bandwidth will enable broadband ob- servations without the limitations and disadvantages of hybrid spectrometers. Spectrometers like the OMS will be important for both ground-based observatories and future space missions like the Single Aperture Far-Infrared Telescope (SAFIR) which might carry IR/submm array heterodyne receiver systems requiring a spectrometer for each array pixel. Small size, low mass and small power consumption are extremely important for space missions. This report summarizes the specifications developed for the OMS and lists already identified commercial parts. The report starts with a review of the principle of operation, then describes the most important components and their specifications which were derived from theory, and finishes with a conclusion and outlook.

  10. Design and development of a work robot to place ATLAS SCT modules onto barrel cylinders

    International Nuclear Information System (INIS)

    Terada, S.; Kobayashi, H.; Sengoku, H.; Kato, Y.; Hara, K.; Honma, F.; Ikegami, Y.; Iwata, Y.; Kohriki, T.; Kondo, T.; Nakano, I.; Takashima, R.; Tanaka, R.; Ujiie, N.; Unno, Y.; Yasuda, S.

    2005-01-01

    More than 2000 silicon modules need to be placed and fastened on the ATLAS SCT barrel tracker. A semi-automatic pick-and-place work robot was designed and developed to cope with the module placement for the SCT barrel assembly. We found that this robot could place modules to a mechanical precision of better than 25 μm

  11. Development of a multi-purpose logic module with the FPGA

    International Nuclear Information System (INIS)

    Nanbu, K.; Ishikawa, T.; Shimizu, H.

    2008-01-01

    We have developed a multi-purpose logic module (MPLM) with an FPGA. The internal circuit of this module can be modified easily with the FPGA. This kind of module enables trigger pulse processing for nuclear science. As a first step, the MPLM is used as an event tag generator in experiments with the FOREST detector system. (author)

  12. Design and development of a work robot to place ATLAS SCT modules onto barrel cylinders

    CERN Document Server

    Terada, S; Honma, F; Ikegami, Y; Iwata, Y; Kato, Y; Kobayashi, H; Kohriki, T; Kondo, T; Nakano, I; Sengoku, H; Takashima, R; Tanaka, R; Ujiie, N; Unno, Y; Yasuda, S

    2005-01-01

    More than 2000 silicon modules need to be placed and fastened on the ATLAS SCT barrel tracker. A semi-automatic pick-and-place work robot was designed and developed to cope with the module placement for the SCT barrel assembly. We found that this robot could place modules to a mechanical precision of better than 25 mum.

  13. Development of High Performance Cooling Modules in Notebook PC's

    Science.gov (United States)

    Tanahashi, Kosei

    The CPU power consumption in Notebook PCs is increasing every year. Video chips and HDDs are also continually using larger power for higher performance. In addition, since miniaturization is desired, the mounting of components is becoming more and more dense. Accordingly, the cooling mechanisms are increasingly important. The cooling modules have to dissipate larger amounts of heat in the same environmental conditions. Therefore, high capacity cooling capabilities is needed, while low costs and high reliability must be retained. Available cooling methods include air or water cooling systems and the heat conduction method. The air cooling system is to transmit heat by a cooling fan often using a heat pipe. The water cooling one employs the water to carry heat to the back of the display, which offers a comparatively large cooling area. The heat conduction method is to transfer the heat by thermal conduction to the case. This article describes the development of new and comparatively efficient cooling devices offering low cost and high reliability for air cooling system. As one of the development techniques, the heat resistance and performance are measured for various parts and layouts. Each cooling system is evaluated in the same measurement environment. With regards to the fans, an optimal shape of the fan blades to maximize air flow is found by using CFD simulation, and prototypes were built and tested.

  14. Maternal modulation of paternal effects on offspring development.

    Science.gov (United States)

    Mashoodh, Rahia; Habrylo, Ireneusz B; Gudsnuk, Kathryn M; Pelle, Geralyn; Champagne, Frances A

    2018-03-14

    The paternal transmission of environmentally induced phenotypes across generations has been reported to occur following a number of qualitatively different exposures and appear to be driven, at least in part, by epigenetic factors that are inherited via the sperm. However, previous studies of paternal germline transmission have not addressed the role of mothers in the propagation of paternal effects to offspring. We hypothesized that paternal exposure to nutritional restriction would impact male mate quality and subsequent maternal reproductive investment with consequences for the transmission of paternal germline effects. In the current report, using embryo transfer in mice, we demonstrate that sperm factors in adult food restricted males can influence growth rate, hypothalamic gene expression and behaviour in female offspring. However, under natural mating conditions females mated with food restricted males show increased pre- and postnatal care, and phenotypic outcomes observed during embryo transfer conditions are absent or reversed. We demonstrate that these compensatory changes in maternal investment are associated with a reduced mate preference for food restricted males and elevated gene expression within the maternal hypothalamus. Therefore, paternal experience can influence offspring development via germline inheritance, but mothers can serve as a modulating factor in determining the impact of paternal influences on offspring development. © 2018 The Author(s).

  15. Automatically changing modules in modular ontology development and management

    CSIR Research Space (South Africa)

    Khan, Zubeida C

    2017-09-01

    Full Text Available Modularity has been proposed as a solution to deal with large ontologies. This requires, various module management tasks, such as swapping an outdated module for a new one or a computationally costly one for a leaner fragment. No mechanism exists...

  16. Development of thin-film Si HYBRID solar module

    Energy Technology Data Exchange (ETDEWEB)

    Nakajima, Akihiko; Gotoh, Masahiro; Sawada, Toru; Fukuda, Susumu; Yoshimi, Masashi; Yamamoto, Kenji; Nomura, Takuji [Kaneka Corporation, 2-1-1, Hieitsuji, Otsu, Shiga 520-0104 (Japan)

    2009-06-15

    The device current-voltage (I-V) characteristics of thin-film silicon stacked tandem solar modules (HYBRID modules), consisting of a hydrogenated amorphous silicon (a-Si:H) cell and a thin-film crystalline silicon solar cell ({mu}c-Si), have been investigated under various spectral irradiance distributions. The performance of the HYBRID module varied periodically in natural sunlight due to the current-limiting property of the HYBRID module and the environmental effects. The behavior based on the current-limiting property was demonstrated by the modelling of the I-V curves using the linear interpolation method for each component cell. The improvement of the performance for the HYBRID module in natural sunlight will also be discussed from the viewpoint of the device design of the component cells. (author)

  17. Development of performance analysis support modules in Younggwang NPP unit 3 and 4

    International Nuclear Information System (INIS)

    Heo, G. Y.; Lee, S. J.; Jang, S. H.; Choi, S. S.; Choi, Q. H.; Gee, M. H.; Heo, I.

    2003-01-01

    This paper covers the unmeasured parameter estimation module, the performance degradation estimation module, and the performance degradation diagnosis module that are the supporting modules of the thermal performance analysis program of Younggwang nuclear power plant unit 3 and 4, PERUPS (PERformance UPgrade System), which was developed by KHNP, KEPRI, Hoseo university, and ACT. The unmeasured parameter estimation module plays a role in the generation of estimated values for the parameters that are necessary but there are no sensors. The performance degradation estimation module shows the impact for electric gain and loss according to the parameters related to turbine cycle performance. The performance degradation diagnosis module provides the belief according degradation causes considering the measurement uncertainty, analysis uncertainty, and correlation among parameters. Reference data for the development of each module was prepared by a turbine cycle simulation tool, PEPSE. The unmeasured parameter estimation module and the performance degradation estimation module make the estimation correlations by the regression analysis using the reference data. In the performance degradation diagnosis module, Bayesian network is used for the modeling of uncertainty and knowledge-base. The validation of the developed modules was performed by the test data generated by PEPSE, and accomplished by the actual data again

  18. Design and development of neutral beam module components

    International Nuclear Information System (INIS)

    Holl, P.M.; Bulmer, R.H.; Dilgard, L.W.; Horvath, J.A.; Molvik, A.W.; Porter, G.D.; Shearer, J.W.; Slack, D.S.; Colonias, J.S.

    1979-01-01

    The Mirror Fusion Test Facility (MFTF) injection system consists of twenty 20 keV start-up, and twenty-four 80 keV sustaining neutral beam source modules. The neutral beam modules are mounted in four clusters equally spaced around the waist of the vacuum vessel which contains the superconducting magnets. A module is defined here as an assembly consisting of a beam source and the interfacing components between that beam source and the vacuum chamber. Six major interfacing components are the subject of this paper. They are the magnetic shield, the neutralizer duct, the isolation valve, mounting gimbals, aiming bellows and actuators

  19. DEVELOPMENT OF PRESSURIZED CIRCULATING FLUIDIZED BED PARTIAL GASIFICATION MODULE (PGM)

    Energy Technology Data Exchange (ETDEWEB)

    Archie Robertson

    2003-10-29

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building bock that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the July 1--September 30, 2003 time period.

  20. DEVELOPMENT OF PRESSURIZED CIRCULATING FLUIDIZED BED PARTIAL GASIFICATION MODULE (PGM)

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    2003-01-30

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building bock that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the October 1--December 31, 2002 time period.

  1. DEVELOPMENT OF PRESSURIZED CIRCULATING FLUIDIZED BED PARTIAL GASIFICATION MODULE (PGM)

    Energy Technology Data Exchange (ETDEWEB)

    Archie Robertson

    2003-07-23

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building bock that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the April 1--June 30, 2003 time period.

  2. Development of Pressurized Circulating Fluidized Bed Partial Gasification Module (PGM)

    Energy Technology Data Exchange (ETDEWEB)

    A. Robertson

    2003-12-31

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building bock that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the October 1 - December 31, 2003 time period.

  3. Development of a 64-channel 100 ps TDC module

    International Nuclear Information System (INIS)

    Liu Xiaohua; An Qi; Liu Shubin; Su Hong; Zhan Wenlong

    2009-01-01

    Multi-wire drift chamber at external target experiment in HIRFL-CSR measures drift time of charged particles to obtain the track information. A 64-channel TDC module hosting high density connectors and high performance TDC chips (HPTDC) are used to perform the time digitization. Data of the module is transferred to computer through PXI bus. The test results show that a 100 ps resolution has been achieved. (authors)

  4. Modulation of Rhamm (CD168) for selective adipose tissue development

    Science.gov (United States)

    Turley, Eva A; Bissell, Mina J

    2014-05-06

    Herein is described the methods and compositions for modulation of Rhamm, also known as CD 186, and its effects on wound repair, muscle differentiation, bone density and adipogeneisis through its ability to regulate mesenchymal stem cell differentiation. Compositions and methods are provided for blocking Rhamm function for selectively increasing subcutaneous, but not, visceral fat. Compositions and methods for modulating Rhamm in wound repair are also described.

  5. Developing Project Based Learning E-Module for the Course of Video Editing

    Directory of Open Access Journals (Sweden)

    Ketut Krisnayuni

    2017-04-01

    Full Text Available This study examined the development of an electronic module for the course of video editing and analyzed the students’ response of the e-module. A waterfall model was adopted in the development process of the e-module that consisted of five stages namely (1 analysis; (2 design; (3 implementation; (4 evaluation; and (5 maintenance. The subjects of this study were the students of class XI at SMK Negeri 1 Sukasada. Project Based Learning was used as the basis of the e-module development as the most relevant learning model to meet the students’needs and the schools’ situation. The data of the students’ response about the e-module were collected through a questionnaire. The students’ response was very positive indicated by the mean score of 94,37. It was concluded that the developed e-modul was categorized as very good.

  6. Development of Smartphone e-Modul by Problem Solving Method for Biot-Savart Theory

    Science.gov (United States)

    Prastyaningrum, Ihtiari; Handhika, Jeffry

    2017-11-01

    Biot-Savart law is an equation that describes the magnetic field created by a current-carrying wire and allows you to calculate its strength at various points. Biot-Savart law is too difficult to be understood, especially about the mathematics concept. Based on the situation, developed an interactive media that’s an Electronic Module. This module based on the problem-solving method and can be accessed by smartphone. This research by using a development method, where is, an electronic module is created by Adobe Flash software. By the development of this module is expected that can improve the ability of mathematics concept analytical.

  7. Effect of Career Education Module on Career Development of Community College Students

    Science.gov (United States)

    Talib, Jasmi A.; Salleh, Amla; Amat, Salleh; Ghavifekr, Simin; Ariff, Azlinda M.

    2015-01-01

    Using a pre-post and control group design, we examined the effect of a career education module on career development among a group of 122 community college students in Malaysia. The effect of gender and the interaction effect of gender and career education module on career development were also investigated. MANOVA analyses showed significant…

  8. Research and development of peripheral technology for photovoltaic power systems. Research and development of photovoltaic modules integrated with construction materials (detachable plane panel); Shuhen gijutsu no kenkyu kaihatsu. Kenzai ittaigata module no kenkyu kaihatsu (chakudatsushiki heiban panel)

    Energy Technology Data Exchange (ETDEWEB)

    Tatsuta, M [New Energy and Industrial Technology Development Organization, Tokyo (Japan)

    1994-12-01

    This paper reports the study results on R and D of photovoltaic modules integrated with construction materials in fiscal 1994. (1) On development of technology for module structures, specifications of the horizontal muntin system module were newly determined in addition to the improved muntin system module, and the prototype pseudo-module integrated with construction material was prepared. The comparison results of the basic performance of both system modules clarified superior waterproofing and module temperature uniformity of the horizontal muntin system. Based on this specifications, integration technology of modules with back metal plates was studied. Formation of the integrated module close to final specifications was ascertained to be possible by use of passivation equipment to irregular form. (2) On development of construction and installation methods of modules, improvement of the waterproofing and workability of both system modules was studied. (3) On the study on practical use of modules, their design and ventilation/cooling structure were studied. 38 figs., 13 tabs.

  9. New development of neutron spectral modulation data analysis

    International Nuclear Information System (INIS)

    Ito, Y.

    1988-01-01

    A study is made on procedures for obtaining desired scattering function information. The neutron spectral modulation technique incorporates both the low (including DC) and high frequency Fourier components in its incident spectrum. Lake's procedure increases the Fourier components of the doconvoluted scattering function by using the existing Fourier components as nucleus, thereby bridges the Fourier gap and extends the Fourier region. Since the Lake's procedure takes care of the missing Fourier components, a single measurement using an appropriate NSM modulation suffices to recover the S(W) line shape. Deep modulation depth is not essential to reproduce the scattering function. This should be contrasted to the previous NSM treatment as well as to the neutron spin echo method, both of which require the several repeat of measurements with the varying modulation frequency under the high degree of beam polarization condition. Although the computer simulation of the present paper does not include the statistical fluctuation encountered in the experimental data, these analyses show a great promise of the NSM method, which can now be used with much flexibility in the field of both cold and ultracold neutron scattering experiment. (N.K.)

  10. Development Strategies for Online Volunteer Training Modules: A Team Approach

    Science.gov (United States)

    Robideau, Kari; Vogel, Eric

    2014-01-01

    Volunteers are central to the delivery of 4-H programs, and providing quality, relevant training is key to volunteer success. Online, asynchronous modules are an enhancement to a training delivery menu for adult volunteers, providing consistent, accessible options traditionally delivered primarily face to face. This article describes how Minnesota…

  11. The Needs Analysis in Self-Concept Module Development

    Science.gov (United States)

    Yusop, Yusni Mohamad; Sumari, Melati; Mohamed, Fatanah; Said, Shahriza; Azeez, Mohd Ibrahim K.; Jamil, Mohd Ridhuan Mohd

    2015-01-01

    This research studies needs analyses conducted to examine the need for a self-concept module. Two types of analyses had been conducted; content analysis and experts' consensus. Content analysis was conducted to explore the issues of self-concept from the theory and literature perspective. Later, needs analysis had also been carried out to observe…

  12. Development of intergrated accident management assessment technology; development of interface modules of risk-monitoring system

    Energy Technology Data Exchange (ETDEWEB)

    Kang, S. K.; Park, S. K.; Seok, H.; Kim, D. K.; Han, J. K.; Park, B. R. [KOPEC, Taejeon (Korea)

    2002-03-01

    Based on the development of interface modules with FORTE.- DynaRM can quantify risk model very fast (Very frequent risk model quantification is needed for configuration risk management).- risk monitoring system technology transfer to foreign NPPs. Contribution to component failure and maintenance control automation with the development of Tagging control System. On-Line risk monitoring system development by joint team between Korea Atomic Energy Research Institute and KOPEC is a request by KEPCO. The softwares developed in this study is easily implemented at domestic NPPs without extra study or cost. Economic benefit and Software export to foreign NPPs are expected because of the development of technology related to risk monitoring system and its management. 6 refs., 3 figs., 1 tab. (Author)

  13. Identifying the 'right' supplier for module developments-a cross-industrial case analysis

    NARCIS (Netherlands)

    Eggers, Justus Erich; Hofman, Erwin; Schiele, Holger; Holschbach, Elmar

    2017-01-01

    Relational view argues that buying companies should integrate supplier resources in new product development (NPD) projects to realise competitive advantages. Due to decoupling of modules and the associated opportunity to allocate development activities to upstream suppliers, modular product

  14. DEVELOPMENT OF PRESSURIZED CIRCULATING FLUIDIZED BED PARTIAL GASIFICATION MODULE (PGM)

    International Nuclear Information System (INIS)

    Unknown

    2001-01-01

    Foster Wheeler Development Corporation is working under DOE contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% while producing near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The unique aspect of the process is that it utilizes a pressurized circulating fluidized bed partial gasifier and does not attempt to consume the coal in a single step. To convert all the coal to syngas in a single step requires extremely high temperatures ((approx)2500 to 2800F) that melt and vaporize the coal and essentially drive all coal ash contaminants into the syngas. Since these contaminants can be corrosive to power generating equipment, the syngas must be cooled to near room temperature to enable a series of chemical processes to clean the syngas. Foster Wheeler's process operates at much lower temperatures that control/minimize the release of contaminants; this eliminates/minimizes the need for the expensive, complicated syngas heat exchangers and chemical cleanup systems typical of high temperature gasification. By performing the gasification in a circulating bed, a significant amount of syngas can still be produced despite the reduced temperature and the circulating bed allows easy scale up to large size plants. Rather than air, it can also operate with oxygen to facilitate

  15. Development of 24GHz Rectenna for Receiving and Rectifying Modulated Waves

    International Nuclear Information System (INIS)

    Shinohara, Naoki; Hatano, Ken

    2014-01-01

    In this paper, we show experimental results of RF-DC conversion with modulated 24GHz waves. We have already developed class-F MMIC rectenna with resonators for higher harmonics at no modulated 24GHz microwave for RF energy transfer. Dimensions of the MMIC rectifying circuit is 1 mm × 3 mm on GaAs. Maximum RF-DC conversion efficiency is measured 47.9% for a 210 mW microwave input of 24 GHz with a 120 Ω load. The class-F rectenna is based on a single shunt full-wave rectifier. For future application of a simultaneous energy and information transfer system or an energy harvesting from broadcasting waves, input microwave will be modulated. In this paper, we show an experimental result of RF-DC conversion of the class-F rectenna with 24GHz waves modulated by 16QAM as 1st modulation and OFDM as 2nd modulation

  16. Development of 24GHz Rectenna for Receiving and Rectifying Modulated Waves

    Science.gov (United States)

    Shinohara, Naoki; Hatano, Ken

    2014-11-01

    In this paper, we show experimental results of RF-DC conversion with modulated 24GHz waves. We have already developed class-F MMIC rectenna with resonators for higher harmonics at no modulated 24GHz microwave for RF energy transfer. Dimensions of the MMIC rectifying circuit is 1 mm × 3 mm on GaAs. Maximum RF-DC conversion efficiency is measured 47.9% for a 210 mW microwave input of 24 GHz with a 120 Ω load. The class-F rectenna is based on a single shunt full-wave rectifier. For future application of a simultaneous energy and information transfer system or an energy harvesting from broadcasting waves, input microwave will be modulated. In this paper, we show an experimental result of RF-DC conversion of the class-F rectenna with 24GHz waves modulated by 16QAM as 1st modulation and OFDM as 2nd modulation.

  17. Development of conductor feedthrough module of LV electrical penetration assembly for research reactors

    International Nuclear Information System (INIS)

    Luo Zhiyuan; Wang Guangjin; Zhou Bin

    2007-01-01

    A LV electrical penetration assembly with perfusion sealing conductor feedthrough module was developed, which can be used for the connection of internal and external cables through the wall of the research reactor workshop. The LV electrical penetration assembly was combined with several independent modules. The maintenance and replacement of the assembly can be easily done in service. The sealing of conductor feedthrough module was achieved with the perfusion of self-extinguishing epoxy. The leakage between the conductor feedthrough module and the end plate module was blocked with rubber rings. The result of the leakage test and the electrical performance test for the samples of conductor feedthrough module satisfied the requirement of research reactor. The structure of the new electrical penetration assembly is simple and compact. It can be manufactured with mature technology and cost low price. The performance of the assembly is steady. It can be used widely in research reactors. (authors)

  18. Development of an Ethernet enabled microcontroller based module for Superconducting Cyclotron ECR beam line control

    International Nuclear Information System (INIS)

    Chatterjee, M.; Koley, D.; Nabhiraj, P.Y.

    2012-01-01

    An Ethernet enabled control and data acquisition module is developed for remote control and monitoring of the ECR beam line equipment of the Superconducting Cyclotron. The PIC microcontroller based module supports multiple general purpose analog and digital inputs and outputs for interfacing with various equipments and an embedded web server. The remote monitoring and control of the equipment are achieved through the web based user interface. The user authenticated access to control parameters and module configuration parameters ensures the operational safety of the equipment under control. This module is installed in Superconducting Cyclotron ECR beam line for the control and monitoring of vacuum pumping modules, comprising of pumps, gate valves and dual vacuum gauges. The installation of these modules results in a distributed control with localised field cabling and hence better fault diagnosis. (author)

  19. A Pc-interface module has been developed that provides an easy way to interface PC

    International Nuclear Information System (INIS)

    Rifai, Ahmad; Gunawan, Usep Setia

    2003-01-01

    A pc-interface module has been developed that provides an easy way to interface PC with I/O devices. This MSC51 micro controller based module accepts series of commands from a personal computer through a serial port. The commands are defined to easily control 24 I/O lines available on the module. These lines can be individually used as either input or output that make the module very verstile. A command is received by the module on ASCII string basis. Each character sent to the module will give an interrupt. The firmware's interrupt handler will store the character in a buffer until end of command character arrives. The firmware then parses and interpreters the command and responses accordingly

  20. Development of whole core thermal-hydraulic analysis program ACT. 3. Coupling core module with primary heat transport system module

    International Nuclear Information System (INIS)

    Ohtaka, Masahiko; Ohshima, Hiroyuki

    1998-10-01

    A whole core thermal-hydraulic analysis program ACT is being developed for the purpose of evaluating detailed in-core thermal hydraulic phenomena of fast reactors including inter-wrapper flow under various reactor operation conditions. In this work, the core module as a main part of the ACT developed last year, which simulates thermal-hydraulics in the subassemblies and the inter-subassembly gaps, was coupled with an one dimensional plant system thermal-hydraulic analysis code LEDHER to simulate transients in the primary heat transport system and to give appropriate boundary conditions to the core model. The effective algorithm to couple these two calculation modules was developed, which required minimum modification of them. In order to couple these two calculation modules on the computing system, parallel computing technique using PVM (Parallel Virtual Machine) programming environment was applied. The code system was applied to analyze an out-of-pile sodium experiment simulating core with 7 subassemblies under transient condition for code verification. It was confirmed that the analytical results show a similar tendency of experimental results. (author)

  1. Development Modules for Specification of Requirements for a System of Verification of Parallel Algorithms

    Directory of Open Access Journals (Sweden)

    Vasiliy Yu. Meltsov

    2012-05-01

    Full Text Available This paper presents the results of the development of one of the modules of the system verification of parallel algorithms that are used to verify the inference engine. This module is designed to build the specification requirements, the feasibility of which on the algorithm is necessary to prove (test.

  2. Development of Hybrid Courses Utilizing Modules as an Objective in ATE Projects

    Science.gov (United States)

    Payne, James E.; Murphy, Richard M.; Payne, Linda L.

    2017-01-01

    Orangeburg-Calhoun Technical College (OCtech) has been awarded two National Science Foundation Advanced Technological Education (NSF-ATE) grants since 2011 that have the development of module-based hybrid courses in Engineering Technology and Mechatronics as objectives. In this article, the advantages and challenges associated with module-based…

  3. Broadening Student Perspectives on Marketing Research Ethics: Development and Applications of a Teaching Module

    Science.gov (United States)

    Handlin, Amy

    2012-01-01

    This paper describes an ethics module developed by the author to engage marketing research students during the fall semester, when they are bombarded by political polls. The module matches ethically questionable polling practices to similarly troubling practices in marketing research. The goals are to show that ethical principles are not topic- or…

  4. Recent developments in electroabsorption modulators at Acreo Swedish ICT

    Science.gov (United States)

    Wang, Qin; Zhang, Andy Z.; Almqvist, Susanne; Junique, Stephane; Noharet, Bertrand; Platt, Duncan; Salter, Michael; Andersson, Jan Y.

    2015-03-01

    Three types of electroabsorption modulators (EAMs) based on III-V semiconductor multiple quantum wells (MQW) are presented in this work. One is a novel monolithic integration traveling-wave EAM for an analog optical transmitter/transceiver to achieve integrated photonic mm-wave functions for broadband connectivity. Another one is composed of an integrated EAM 1D array in a photonic beam-former as a Ku-band phased array antenna for seamless aeronautical networking through integration of data links, radios, and antennas. The third one addresses the use of MQW EAMs in free space optical links through biological tissue for transcutaneous communication.

  5. Technology developments toward 30-year-life of photovoltaic modules

    Science.gov (United States)

    Ross, R. G., Jr.

    1984-01-01

    As part of the United States National Photovoltaics Program, the Jet Propulsion Laboratory's Flat-Plate Solar Array Project (FSA) has maintained a comprehensive reliability and engineering sciences activity addressed toward understanding the reliability attributes of terrestrial flat-plate photovoltaic arrays and to deriving analysis and design tools necessary to achieve module designs with a 30-year useful life. The considerable progress to date stemming from the ongoing reliability research is discussed, and the major areas requiring continued research are highlighted. The result is an overview of the total array reliability problem and of available means of achieving high reliability at minimum cost.

  6. Development and application of visual support module for remote operator in 3D virtual environment

    International Nuclear Information System (INIS)

    Choi, Kyung Hyun; Cho, Soo Jeong; Yang, Kyung Boo; Bae, Chang Hyun

    2006-02-01

    In this research, the 3D graphic environment was developed for remote operation, and included the visual support module. The real operation environment was built by employing a experiment robot, and also the identical virtual model was developed. The well-designed virtual models can be used to retrieve the necessary conditions for developing the devices and processes. The integration of 3D virtual models, the experimental operation environment, and the visual support module was used for evaluating the operation efficiency and accuracy by applying different methods such as only monitor image and with visual support module

  7. Development and application of visual support module for remote operator in 3D virtual environment

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Kyung Hyun; Cho, Soo Jeong; Yang, Kyung Boo [Cheju Nat. Univ., Jeju (Korea, Republic of); Bae, Chang Hyun [Pusan Nat. Univ., Busan (Korea, Republic of)

    2006-02-15

    In this research, the 3D graphic environment was developed for remote operation, and included the visual support module. The real operation environment was built by employing a experiment robot, and also the identical virtual model was developed. The well-designed virtual models can be used to retrieve the necessary conditions for developing the devices and processes. The integration of 3D virtual models, the experimental operation environment, and the visual support module was used for evaluating the operation efficiency and accuracy by applying different methods such as only monitor image and with visual support module.

  8. Pulse Power Modulator development for the CLIC Damping Ring Kickers

    CERN Document Server

    Holma, Janne

    2012-01-01

    The Compact Linear Collider (CLIC) study is exploring the scheme for an electron-positron collider with high luminosity (10-34 – 10-35 cm-2s-1) and a nominal centre-of-mass energy of 3 TeV: CLIC would complement LHC physics in the multi-TeV range. The CLIC design relies on Pre-Damping Rings (PDR) and Damping Rings (DR) to achieve the very low emittance, through synchrotron radiation, needed for the luminosity requirements of CLIC. To limit the beam emittance blow-up due to oscillations, the pulse power modulators for the DR kickers must provide extremely flat, high-voltage pulses: the 2 GHz specification called for a 160 ns duration flat-top of 12.5 kV, 250 A, with a combined ripple and droop of not more than ±0.02 %. In order to meet these demanding specifications, a combination of broadband impedance matching, optimized electrical circuit layout and advanced control techniques is required. A solid-state modulator, the inductive adder, is the most promising approach to meeting the demanding specifications...

  9. Perancangan SIMRS Terintegrasi Modul Human Resource Development Pada Rumah Sakit Pendidikan

    Directory of Open Access Journals (Sweden)

    A.A Primaningrat Gita Puspita

    2015-11-01

    Full Text Available Human resources at the hospital consists of many kind of disciplines and professions that can be divided into Medical and Non-Medical Personnel. Management Information System Human Resource Development Module needed to accelerate and facilitate the processing of employee data and helpful for management decision making. The module also needs to be integrated with the Payroll Module to facilitate the process of Payroll and remuneration in the hospital. Stage of the system design was conducted by TAS (Total Architecture Syntesis, they are the determination of initial scope, determination of needs, determination of business processes, system design, and evaluation. Human Resource Development Module contains the data collection process, transfer, performance assessment, absences, schedulin, hiring, and reporting. Payroll module contains Payroll and remuneration. This work described by Data Flow Diagrams, Database Structure, and User Interface Design. This design can be used as guidelines for programmers in the manufacture of Hospital Information System are integrated.

  10. Low cost solar array project production process and equipment task. A Module Experimental Process System Development Unit (MEPSDU)

    Science.gov (United States)

    1981-01-01

    Technical readiness for the production of photovoltaic modules using single crystal silicon dendritic web sheet material is demonstrated by: (1) selection, design and implementation of solar cell and photovoltaic module process sequence in a Module Experimental Process System Development Unit; (2) demonstration runs; (3) passing of acceptance and qualification tests; and (4) achievement of a cost effective module.

  11. Electroless Ni-B plating on SiO2 with 3-aminopropyl-triethoxysilane as a barrier layer against Cu diffusion for through-Si via interconnections in a 3-dimensional multi-chip package

    International Nuclear Information System (INIS)

    Ikeda, Akihiro; Sakamoto, Atsushi; Hattori, Reiji; Kuroki, Yukinori

    2009-01-01

    Electroless Ni-B was plated on SiO 2 as a barrier layer against Cu diffusion for through-Si via (TSV) interconnections in a 3-dimensional multi-chip package. The electroless Ni-B was deposited on the entire area of the SiO 2 side wall of a deep via with vapor phase pre-deposition of 3-aminopropyl-triethoxysilane on the SiO 2 . The carrier lifetimes in the Si substrates plated with Ni-B/Cu did not decrease with an increase in annealing temperature up to 400 deg. C . The absence of degradation of carrier lifetimes indicates that Cu atoms did not diffuse into the Si through the Ni-B. The advantages of electroless Ni-B (good conformal deposition and forming an effective diffusion barrier against Cu) make it useful as a barrier layer for TSV interconnections in a 3-dimensional multi-chip package

  12. Development of the pulse transformer for NLC klystron pulse modulator

    International Nuclear Information System (INIS)

    Akemoto, M.; Gold, S.; Koontz, R.; Krasnykh, A.

    1997-05-01

    We have studied a conventional pulse transformer for the NLC klystron pulse modulator. The transformer has been analyzed using a simplified lumped circuit model. It is found that a fast rise time requires low leakage inductance and low distributed capacitance and can be realized by reducing the number of secondary turns, but it produces larger pulse droop and core size. After making a tradeoff among these parameters carefully, a conventional pulse transformer with a rise time of 250ns and pulse droop of 3.6% has been designed and built. The transmission characteristics and pulse time-response were measured. The data were compared with the model. The agreement with the model was good when the measured values were used in the model simulation. The results of the high voltage tests are also presented

  13. DEVELOPMENT OF BUSINESS SKILLS MODULE FOR HUMAN CAPITAL MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Moré, Dailien

    2015-12-01

    Full Text Available Today firms advocate buy a business improvement depends on proper reach staff selection considering the level of commitment, work attitude, skills and competencies of each person in the performance of the functions of the various fees and jobs. This research proposes a module occupational competency (CL that would strengthen the Human Capital Management (GCH. The proposal may encourage national institutions and increase their productivity sustained employment success for the country. For the realization of the solution was carried out the study of business processes and methods of multicriterial decision-making. Following the completion of the design, the solution was implemented and the identified components were integrated, the results of the data obtained showed the feasibility of the contribution to the solution of the problem.

  14. Development of allosteric modulators of GPCRs for treatment of CNS disorders.

    Science.gov (United States)

    Nickols, Hilary Highfield; Conn, P Jeffrey

    2014-01-01

    The discovery of allosteric modulators of G protein-coupled receptors (GPCRs) provides a promising new strategy with potential for developing novel treatments for a variety of central nervous system (CNS) disorders. Traditional drug discovery efforts targeting GPCRs have focused on developing ligands for orthosteric sites which bind endogenous ligands. Allosteric modulators target a site separate from the orthosteric site to modulate receptor function. These allosteric agents can either potentiate (positive allosteric modulator, PAM) or inhibit (negative allosteric modulator, NAM) the receptor response and often provide much greater subtype selectivity than orthosteric ligands for the same receptors. Experimental evidence has revealed more nuanced pharmacological modes of action of allosteric modulators, with some PAMs showing allosteric agonism in combination with positive allosteric modulation in response to endogenous ligand (ago-potentiators) as well as "bitopic" ligands that interact with both the allosteric and orthosteric sites. Drugs targeting the allosteric site allow for increased drug selectivity and potentially decreased adverse side effects. Promising evidence has demonstrated potential utility of a number of allosteric modulators of GPCRs in multiple CNS disorders, including neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, as well as psychiatric or neurobehavioral diseases such as anxiety, schizophrenia, and addiction. © 2013.

  15. EPICS IOC module development and implementation for the ISTTOK machine subsystem operation and control

    Energy Technology Data Exchange (ETDEWEB)

    Carvalho, Paulo, E-mail: pricardofc@ipfn.ist.utl.pt [Associacao EURATOM/IST, Instituto de Plasmas e Fusao Nuclear-Laboratorio Associado, Instituto Superior Tecnico, P-1049-001 Lisboa (Portugal); Duarte, Andre; Pereira, Tiago; Carvalho, Bernardo; Sousa, Jorge; Fernandes, Horacio [Associacao EURATOM/IST, Instituto de Plasmas e Fusao Nuclear-Laboratorio Associado, Instituto Superior Tecnico, P-1049-001 Lisboa (Portugal); Correia, Carlos [Grupo de Electronica e Instrumentacao-Centro de Instrumentacao, Departamento de Fisica, Universidade de Coimbra, P-3004-516 Coimbra (Portugal); Goncalves, Bruno; Varandas, Carlos [Associacao EURATOM/IST, Instituto de Plasmas e Fusao Nuclear-Laboratorio Associado, Instituto Superior Tecnico, P-1049-001 Lisboa (Portugal)

    2011-10-15

    This paper presents a developed, tested and integrated EPICS IOC (I/O controller) module solution for the ISTTOK tokamak machine operation and control for the vacuum and gas injection systems. The work is organized in two software layers which communicate through a serial RS-232 communication protocol. The first software layer is an EPICS IOC module running as a computer server application capable of receiving requests from remote or local clients providing driver interface to the system by forwarding requested commands and receiving system and control operation status. The second software layer is the firmware running in Microchip dsPIC microcontroller modules which performs the interface from RS-232 optical fiber serial protocol to EPICS IOC module. The dsPIC module communicates to the ISTTOK tokamak sensors and actuators via RS-485 and is programmed with a new protocol developed for this purpose that allows EPICS IOC module command sending/receiving, machine operation control and monitoring and system status information. Communication between EPICS IOC module and clients is achieved via a TCP/IP and UDP protocol referred as Channel Access. In addition, the EPICS IOC module provides user client applications access allowing operators to perform remote or local monitoring, operation and control.

  16. Develop railway engineering modules in UTK civil engineering undergraduate and graduate courses.

    Science.gov (United States)

    2015-05-31

    The importance of railway transport has long been recognized. However, no railway : engineering courses have been provided in the UTK civil engineering curricula. The : objective of this education project is to develop some railway engineering module...

  17. Intrathymic immune modulation prevents acute rejection but not the development of graft arteriosclerosis (chronic rejection)

    NARCIS (Netherlands)

    Hillebrands, JL; Raue, HP; Klatter, FA; Hylkema, MN; Platteel, [No Value; Hardonk-Wubbena, A; Nieuwenhuis, P; Rozing, J

    2001-01-01

    Background. We showed previously that our intrathymic immune modulation protocol induces virtually permanent graft survival of simultaneously transplanted cardiac allografts in MHC-incompatible rat strain combinations. It is, however, unknown whether this procedure prevents the development of graft

  18. Development and validation status of the IFMIF High Flux Test Module

    International Nuclear Information System (INIS)

    Arbeiter, Frederik; Abou-Sena, Ali; Chen Yuming; Dolensky, Bernhard; Heupel, Tobias; Klein, Christine; Scheel, Nicola; Schlindwein, Georg

    2011-01-01

    The development of the IFMIF (International Fusion Material Irradiation Facility) High Flux Test Module in the EVEDA (Engineering Validation and Engineering Design Activities) phase up to 2013 includes conceptual design, engineering analyses, as well as design and engineering validation by building of prototypes and their testing. The High Flux Test Module is the device to facilitate the irradiation of SSTT samples of RAFM steels at temperatures 250-550 deg. C and up to an accumulated irradiation damage of 150 dpa. The requirements, the current design and the performance of the module are discussed, and the development process is outlined.

  19. Development and validation status of the IFMIF High Flux Test Module

    Energy Technology Data Exchange (ETDEWEB)

    Arbeiter, Frederik, E-mail: frederik.arbeiter@kit.edu [Karlsruhe Institute of Technology, Institute for Neutron Physics and Reactor Technology (KIT-INR), Karlsruhe (Germany); Abou-Sena, Ali; Chen Yuming; Dolensky, Bernhard; Heupel, Tobias; Klein, Christine; Scheel, Nicola; Schlindwein, Georg [Karlsruhe Institute of Technology, Institute for Neutron Physics and Reactor Technology (KIT-INR), Karlsruhe (Germany)

    2011-10-15

    The development of the IFMIF (International Fusion Material Irradiation Facility) High Flux Test Module in the EVEDA (Engineering Validation and Engineering Design Activities) phase up to 2013 includes conceptual design, engineering analyses, as well as design and engineering validation by building of prototypes and their testing. The High Flux Test Module is the device to facilitate the irradiation of SSTT samples of RAFM steels at temperatures 250-550 deg. C and up to an accumulated irradiation damage of 150 dpa. The requirements, the current design and the performance of the module are discussed, and the development process is outlined.

  20. Inspiring Climate Education Excellence(ICEE): Developing Elearning professional development modules - secondary science teachers

    Science.gov (United States)

    Kellagher, E.; Buhr, S. M.; Lynds, S. E.; McCaffrey, M. S.; Cires Education Outreach

    2011-12-01

    Inspiring Climate Education Excellence (ICEE) is a NASA-funded project to develop content knowledge and knowledge of effective teaching strategies in climate education among secondary science teachers. ICEE resources are aligned with the Essential Principles of Climate Science. Building upon a needs assessment and face to face workshop, ICEE resources include iTunesU videos, an ICEE 101 resource site with videos and peer-reviewed learning activities, and a moderated online forum. Self-directed modules and an online course are being developed around concepts and topics in which teachers express the most interest and need for instruction. ICEE resources include attention to effective teaching strategies, such as awareness of student misconceptions, strategies for forestalling controversy and advice from master teachers on implementation and curriculum development. The resources are being developed in partnership with GLOBE, and the National Science Digital Library (NSDL) and are informed by the work of the Climate Literacy and Energy Awareness Network (CLEAN) project. ICEE will help to meet the professional development needs of teachers, including those participating in the GLOBE Student Climate Research Campaign.

  1. Developing workshop module of realistic mathematics education: Follow-up workshop

    Science.gov (United States)

    Palupi, E. L. W.; Khabibah, S.

    2018-01-01

    Realistic Mathematics Education (RME) is a learning approach which fits the aim of the curriculum. The success of RME in teaching mathematics concepts, triggering students’ interest in mathematics and teaching high order thinking skills to the students will make teachers start to learn RME. Hence, RME workshop is often offered and done. This study applied development model proposed by Plomp. Based on the study by RME team, there are three kinds of RME workshop: start-up workshop, follow-up workshop, and quality boost. However, there is no standardized or validated module which is used in that workshops. This study aims to develop a module of RME follow-up workshop which is valid and can be used. Plopm’s developmental model includes materials analysis, design, realization, implementation, and evaluation. Based on the validation, the developed module is valid. While field test shows that the module can be used effectively.

  2. Module and electronics developments for the ATLAS ITK pixel system

    CERN Document Server

    Nellist, Clara; The ATLAS collaboration

    2016-01-01

    Summary ATLAS is preparing for an extensive modification of its detector in the course of the planned HL‐ LHC accelerator upgrade around 2025 which includes a replacement of the entire tracking system by an all‐silicon detector (Inner Tracker, ITk). A revised trigger and data taking system is foreseen with triggers expected at lowest level at an average rate of 1 MHz. The five innermost layers of ITk will comprise of a pixel detector built of new sensor and readout electronics technologies to improve the tracking performance and cope with the severe HL‐LHC environment in terms of occupancy and radiation. The total area of the new pixel system could measure up to 14 m2, depending on the final layout choice that is expected to take place in early 2017. A new on‐detector readout chip is designed in the context of the RD53 collaboration in 65 nm CMOS technology. This paper will present the on‐going R&D within the ATLAS ITK project towards the new pixel modules and the off‐detector electronics. Pla...

  3. Module and electronics developments for the ATLAS ITK pixel system

    CERN Document Server

    Munoz Sanchez, Francisca Javiela; The ATLAS collaboration

    2017-01-01

    ATLAS is preparing for an extensive modification of its detector in the course of the planned HL-LHC accelerator upgrade around 2025 which includes a replacement of the entire tracking system by an all-silicon detector (Inner Tracker, ITk). The five innermost layers of ITk will comprise of a pixel detector built of new sensor and readout electronics technologies to improve the tracking performance and cope with the severe HL-LHC environment in terms of occupancy and radiation. The total area of the new pixel system could measure up to 14 m2, depending on the final layout choice that is expected to take place in 2017. A new on-detector readout chip is designed in the context of the RD53 collaboration in 65 nm CMOS technology. This paper will present the on-going R&D within the ATLAS ITK project towards the new pixel modules and the off-detector electronics. Planar and 3D sensors are being re-designed with cell sizes of 50x50 or 25x100 μm2, compatible with the RD53 chip. A sensor thickness equal or less th...

  4. Developing ADUN e-Community Portal for Community in Malaysia: Announcement Module and Discussion Module

    OpenAIRE

    Nur Fatin Binti Eisa; Ahmad Suhaimi Baharudin; Kamal Karkonasasi

    2016-01-01

    Nowadays, there are many government agencies had already developed a portal sites for their citizens. This kind of portal is found to be particularly useful to those who faced certain problem regarding their dissatisfaction on the government's service. However, the main disadvantage of such portal is the lack of their public services to the citizens. Thus, ADUN e-community portal is designed to utilize information and help ADUN to manage the complaints created by the community. By using th...

  5. Development of a Burnup Module DECBURN Based on the Krylov Subspace Method

    Energy Technology Data Exchange (ETDEWEB)

    Cho, J. Y.; Kim, K. S.; Shim, H. J.; Song, J. S

    2008-05-15

    This report is to develop a burnup module DECBURN that is essential for the reactor analysis and the assembly homogenization codes to trace the fuel composition change during the core burnup. The developed burnup module solves the burnup equation by the matrix exponential method based on the Krylov Subspace method. The final solution of the matrix exponential is obtained by the matrix scaling and squaring method. To develop DECBURN module, this report includes the followings as: (1) Krylov Subspace Method for Burnup Equation, (2) Manufacturing of the DECBURN module, (3) Library Structure Setup and Library Manufacturing, (4) Examination of the DECBURN module, (5) Implementation to the DeCART code and Verification. DECBURN library includes the decay constants, one-group cross section and the fission yields. Examination of the DECBURN module is performed by manufacturing a driver program, and the results of the DECBURN module is compared with those of the ORIGEN program. Also, the implemented DECBURN module to the DeCART code is applied to the LWR depletion benchmark and a OPR-1000 pin cell problem, and the solutions are compared with the HELIOS code to verify the computational soundness and accuracy. In this process, the criticality calculation method and the predictor-corrector scheme are introduced to the DeCART code for a function of the homogenization code. The examination by a driver program shows that the DECBURN module produces exactly the same solution with the ORIGEN program. DeCART code that equips the DECBURN module produces a compatible solution to the other codes for the LWR depletion benchmark. Also the multiplication factors of the DeCART code for the OPR-1000 pin cell problem agree to the HELIOS code within 100 pcm over the whole burnup steps. The multiplication factors with the criticality calculation are also compatible with the HELIOS code. These results mean that the developed DECBURN module works soundly and produces an accurate solution

  6. Development of Active External Network Topology Module for Floodlight SDN Controller

    Directory of Open Access Journals (Sweden)

    A. A. Noskov

    2015-01-01

    Full Text Available Traditional network architecture is inflexible and complicated. This observation has led to a paradigm shift towards software-defined networking (SDN, where network management level is separated from data forwarding level. This change was made possible by control plane transfer from the switching equipment to software modules that run on a dedicated server, called the controller (or network operating system, or network applications, that work with this controller. Methods of representation, storage and communication interfaces with network topology elements are the most important aspects of network operating systems available to SDN user because performance of some key controller modules is heavily dependent on internal representation of the network topology. Notably, firewall and routing modules are examples of such modules. This article describes the methods used for presentation and storage of network topologies, as well as interface to the corresponding Floodlight modules. An alternative algorithm has been suggested and developed for message exchange conveying network topology alterations between the controller and network applications. Proposed algorithm makes implementation of module alerting based on subscription to the relevant events. API for interaction between controller and network applications has been developed. This algorithm and API formed the base for Topology Tracker module capable to inform network applications about the changes that had occurred in the network topology and also stores compact representation of the network to speed up the interaction process.

  7. Development of a Compact Wireless Laplacian Electrode Module for Electromyograms and Its Human Interface Applications

    Directory of Open Access Journals (Sweden)

    Akira Ichikawa

    2013-02-01

    Full Text Available In this study, we developed a compact wireless Laplacian electrode module for electromyograms (EMGs. One of the advantages of the Laplacian electrode configuration is that EMGs obtained with it are expected to be sensitive to the firing of the muscle directly beneath the measurement site. The performance of the developed electrode module was investigated in two human interface applications: character-input interface and detection of finger movement during finger Braille typing. In the former application, the electrode module was combined with an EMG-mouse click converter circuit. In the latter, four electrode modules were used for detection of finger movements during finger Braille typing. Investigation on the character-input interface indicated that characters could be input stably by contraction of (a the masseter, (b trapezius, (c anterior tibialis and (d flexor carpi ulnaris muscles. This wide applicability is desirable when the interface is applied to persons with physical disabilities because the disability differs one to another. The investigation also demonstrated that the electrode module can work properly without any skin preparation. Finger movement detection experiments showed that each finger movement was more clearly detectable when comparing to EMGs recorded with conventional electrodes, suggesting that the Laplacian electrode module is more suitable for detecting the timing of finger movement during typing. This could be because the Laplacian configuration enables us to record EMGs just beneath the electrode. These results demonstrate the advantages of the Laplacian electrode module.

  8. Pleiotropic Effects of Neurotransmission during Development: Modulators of Modularity

    Science.gov (United States)

    Thompson, Barbara L.; Stanwood, Gregg D.

    2009-01-01

    The formation and function of the mammalian cerebral cortex relies on the complex interplay of a variety of genetic and environmental factors through protracted periods of gestational and postnatal development. Biogenic amine systems are important neuromodulators, both in the adult nervous system, and during critical epochs of brain development.…

  9. Reviewing a Reading Program: Professional Development Module. Participant's Guide

    Science.gov (United States)

    Kosanovich, Marcia; Jordan, Georgia; Arndt, Elissa; Van Sciver, Mary; Wahl, Michelle; Rissman, Lila

    2008-01-01

    The Curriculum and Instructional Projects Team at the Florida Center for Reading Research (FCRR) developed "Guidelines for Reviewing a Reading Program" ("Guidelines") to assist reviewers in determining if a program is consistent with the scientific research on reading. Based on that work, the Center on Instruction Reading Strand developed this…

  10. Handling Uncertainties within R&D Modules of a developing Technology

    DEFF Research Database (Denmark)

    Pedersen, Jørgen Lindgaard; Perunovic, Zoran

    2004-01-01

    . Third, the modules that have had always been present in the insulin's R&D, enabled companies to develop mechanism for internal learning and are able to master that part of the process. Finally, in the R&D, outsourcing is related to the whole knowledge acquisition while it seems that minor uncertainties...... and an interview conducted have generated following. First, the further along the process train a module is, it accumulates uncertainties from previous modules. Second, with the growth of complexity, uncertainties grew as well, resulting in the necessity for companies to seek for knowledge on them externally...

  11. Development of a diagnostic system for Klystron modulators using a neural network

    International Nuclear Information System (INIS)

    Mutoh, M.; Oonuma, T.; Shibasaki, Y.; Abe, I.; Nakahara, K.

    1992-01-01

    The diagnostic system for klystron modulators using a neural network has been developed. Large changes in the voltage and current of the main circuit in a klystron modulator were observed just several ten milli-seconds before the modulator experienced trouble. These changes formed a peculiar pattern that depended on the parts with problems. Diagnosis was possible by means of pattern recognition. The recognition test of patterns using a neutral network has shown good results. This system, which is built in a linac control system, is presently being operated so as to collect new trouble patterns and to carry out tests for practical use. (author)

  12. Development and validation of I x V curve tracer for photovoltaic modules

    OpenAIRE

    MÃrcio Leal Macedo Luna

    2016-01-01

    The IxV curves tracers for PV modules are used as a method of diagnosis of problems such as shadowing, faulty connections and degradation conditions. There are several types and brands tracers commercially available, but their costs are quite high in the Brazilian market due to the need to import. This thesis describes the development and validation of a IxV curve tracer for PV modules based on the electronic load method using MOSFET as load to the module. By appropriate variation of the MOSF...

  13. Compact electro-thermal modeling of a SiC MOSFET power module under short-circuit conditions

    DEFF Research Database (Denmark)

    Ceccarelli, Lorenzo; Reigosa, Paula Diaz; Bahman, Amir Sajjad

    2017-01-01

    A novel physics-based, electro-thermal model which is capable of estimating accurately the short-circuit behavior and thermal instabilities of silicon carbide MOSFET multi-chip power modules is proposed in this paper. The model has been implemented in PSpice and describes the internal structure.......2 kV breakdown voltage and about 300 A rated current. The short-circuit behavior of the module is investigated experimentally through a non-destructive test setup and the model is validated. The estimation of overcurrent and temperature distribution among the chips can provide useful information...

  14. Evaluation of a Team Project Based Learning Module for Developing Employability Skills

    OpenAIRE

    Janice Whatley

    2012-01-01

    This paper presents a case study, in which a new module, aimed at enhancing students’ employ-ability skills, is evaluated. Employability skills for graduates from higher education are regarded as essential outcomes from their degree programmes, but it can be difficult to provide appropriate opportunities to develop these skills in the context of their studies. This paper describes a new module, called Live Projects, designed to provide project based learning on campus, but involv-ing local bu...

  15. Development of core thermal-hydraulics module for intelligent reactor design system (IRDS)

    International Nuclear Information System (INIS)

    Kugo, Teruhiko; Nakagawa, Masayuki; Fujii, Sadao.

    1994-08-01

    We have developed an innovative reactor core thermal-hydraulics module where a designer can easily and efficiently evaluate his design concept of a new type reactor in the thermal-hydraulics field. The main purpose of this module is to decide a feasible range of basic design parameters of a reactor core in a conceptual design stage of a new type reactor. The module is to be implemented in Intelligent Reactor Design System (IRDS). The module has the following characteristics; 1) to deal with several reactor types, 2) four thermal hydraulics and fuel behavior analysis codes are installed to treat different type of reactors and design detail, 3) to follow flexibly modification of a reactor concept, 4) to provide analysis results in an understandable way so that a designer can easily evaluate feasibility of his concept, and so on. The module runs on an engineering workstation (EWS) and has a user-friendly man-machine interface on a pre- and post-processing. And it is equipped with a function to search a feasible range called as Design Window, for two design parameters by artificial intelligence (AI) technique and knowledge engineering. In this report, structure, guidance for users of an usage of the module and instruction of input data for analysis modules are presented. (author)

  16. Recent developments in the economic modeling of photovoltaic module manufacturing

    Science.gov (United States)

    Chamberlain, R. G.

    1979-01-01

    Recent developments in the solar array manufacturing industry costing standards (SAMICS) are described. Consideration is given to the added capability to handle arbitrary operating schedules and the revised procedure for calculation of one-time costs. The results of an extensive validation study are summarized.

  17. The Tale of Two Virtual Teacher Professional Development Modules

    Science.gov (United States)

    Keown, Paul

    2009-01-01

    Virtual communities of practice (VCoP) have been advocated for some time as a promising means of taking professional development to teachers in widely distributed locations. However, geography, and indeed education literature as a whole, contains very few examples where this has been achieved. This paper reports on two VCoP professional…

  18. Reviewing a Reading Program: Professional Development Module. Facilitator's Guide

    Science.gov (United States)

    Kosanovich, Marcia; Jordan, Georgia; Arndt, Elissa; VanSciver, Mary; Wahl, Michelle; Rissman, Lila

    2008-01-01

    This "Facilitator's Guide" has been prepared for presenters of the Reviewing a Reading Program professional development training. It is one of three pieces comprising a suite of materials on reviewing reading programs: this "Guide", the "Reviewing a Reading Program Participant's Guide" and the "Reviewing a Reading Program" Professional Development…

  19. Developing SPPVM modules with visual basic | Ekpenyong | Global ...

    African Journals Online (AJOL)

    PVMs enable large computational problems to be solved more cost effectively by using aggregated power and memory of many computers. This paper develops a SPPVM (Single Processor Parallel Virtual Machine) with Visual Basic. It employs the VB Shell command to cause a single program or instruction to execute in ...

  20. Rac1 modulates cardiomyocyte adhesion during mouse embryonic development

    Energy Technology Data Exchange (ETDEWEB)

    Abu-Issa, Radwan, E-mail: rabuissa@umich.edu

    2015-01-24

    Highlights: • Conditional knockout of Rac1 using Nkx2.5 Cre line is lethal at E13.5. • The myocardium of the mutant is thin and disorganized. • The phenotype is not due to cardiomyocyte low proliferation or apoptosis. • The phenotype is due to specific defect in cardiomyocyte adhesion. - Abstract: Rac1, a member of the Rho subfamily of small GTPases, is involved in morphogenesis and differentiation of many cell types. Here we define a role of Rac1 in cardiac development by specifically deleting Rac1 in the pre-cardiac mesoderm using the Nkx2.5-Cre transgenic driver line. Rac1-conditional knockout embryos initiate heart development normally until embryonic day 11.5 (E11.5); their cardiac mesoderm is specified, and the heart tube is formed and looped. However, by E12.5-E13.5 the mutant hearts start failing and embryos develop edema and hemorrhage which is probably the cause for the lethality observed soon after. The hearts of Rac1-cKO embryos exhibit disorganized and thin myocardial walls and defects in outflow tract alignment. No significant differences of cardiomyocyte death or proliferation were found between developing control and mutant embryos. To uncover the role of Rac1 in the heart, E11.5 primary heart cells were cultured and analyzed in vitro. Rac1-deficient cardiomyocytes were less spread, round and loosely attached to the substrate and to each other implying that Rac1-mediated signaling is required for appropriate cell–cell and/or cellmatrix adhesion during cardiac development.

  1. Rac1 modulates cardiomyocyte adhesion during mouse embryonic development

    International Nuclear Information System (INIS)

    Abu-Issa, Radwan

    2015-01-01

    Highlights: • Conditional knockout of Rac1 using Nkx2.5 Cre line is lethal at E13.5. • The myocardium of the mutant is thin and disorganized. • The phenotype is not due to cardiomyocyte low proliferation or apoptosis. • The phenotype is due to specific defect in cardiomyocyte adhesion. - Abstract: Rac1, a member of the Rho subfamily of small GTPases, is involved in morphogenesis and differentiation of many cell types. Here we define a role of Rac1 in cardiac development by specifically deleting Rac1 in the pre-cardiac mesoderm using the Nkx2.5-Cre transgenic driver line. Rac1-conditional knockout embryos initiate heart development normally until embryonic day 11.5 (E11.5); their cardiac mesoderm is specified, and the heart tube is formed and looped. However, by E12.5-E13.5 the mutant hearts start failing and embryos develop edema and hemorrhage which is probably the cause for the lethality observed soon after. The hearts of Rac1-cKO embryos exhibit disorganized and thin myocardial walls and defects in outflow tract alignment. No significant differences of cardiomyocyte death or proliferation were found between developing control and mutant embryos. To uncover the role of Rac1 in the heart, E11.5 primary heart cells were cultured and analyzed in vitro. Rac1-deficient cardiomyocytes were less spread, round and loosely attached to the substrate and to each other implying that Rac1-mediated signaling is required for appropriate cell–cell and/or cellmatrix adhesion during cardiac development

  2. Development of multifunctional electronic modules for cryogenic applications

    Energy Technology Data Exchange (ETDEWEB)

    Gust, Norbert; Kade, Andreas; Klier, Juergen [Institut fuer Luft- und Kaeltetechnik (ILK) gemeinuetzige Gesellschaft mbH, Dresden (Germany)

    2017-07-01

    A new universal cryogenic measurement system has been developed which can measure resistance and voltages with high precision (< 0.025 %) and low noise (-88 dB) at low powers (< 1 nW) in a high electromagnetic interference environment. The system is effectively designed and equipped with noise and distortion suppressing electronics and algorithms. It can be extended with cryogenic multiplexers for up to 80 sensors, which can be directly mounted inside cryostats for reduced wiring. The size of the devices is relatively small (handheld), low power (< 2 W), can operate on battery and has easy access to calibration and sensor data. Sensor types are not limited and it can be used to measure, e.g., temperature, voltage, magnetic field, pressure and level simultaneously. Within this paper we present our developments and first measurement results. The key components which we describe in detail are cold multiplexers and smart measurement bridges for a wide field of applications.

  3. Development of miniature module for [11C] methionine synthesis

    International Nuclear Information System (INIS)

    Watanabe, Toshimitsu; Araya, Hiroshi; Ueno, Satoshi

    2006-01-01

    [ 18 F]FDG-PET has spread rapidly in the cancer diagnosis. On the other hand, [ 11 C]Methionine is paid attention as one of the PET drugs that may help cancer diagnosis by [ 18 F]FDG. Due to its short half-life, repeated preparations of [ 11 C] Methionine, two or three times a day, are generally required for the routine PET practice. Although the automatic synthesis devices for [ 11 C]Methionine were developed, it was difficult to supply [ 11 C]Methionine two times a day or more. We developed a methionine synthesis system that was able to supply [ 11 C]Methionine two times a day or more, and a new methionine synthesis unit. The new synthesis unit is able to synthesize [ 11 C]Methionine efficiently without HPLC preparation and evaporation in a short time. The new methionine synthesis unit and system are more useful for the routine synthesis of [ 11 C]Methionine. (author)

  4. Paraho oil shale module. Site development plan, Task 4

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-01

    A management plan and schedule which covers all requirements for gaining access to the site and for conducting a Paraho Process demonstration program have been prepared. The oil shale available should represent a regional resource of suitable size and quality for commercial development. Discussed in this report are: proof of ownership; requirements for rights-of-way for access to the site; local zoning restrictions; water rights; site availability verification; and other legal requirements. (DMC)

  5. Perceived live interaction modulates the developing social brain.

    Science.gov (United States)

    Rice, Katherine; Moraczewski, Dustin; Redcay, Elizabeth

    2016-09-01

    Although children's social development is embedded in social interaction, most developmental neuroscience studies have examined responses to non-interactive social stimuli (e.g. photographs of faces). The neural mechanisms of real-world social behavior are of special interest during middle childhood (roughly ages 7-13), a time of increased social complexity and competence coinciding with structural and functional social brain development. Evidence from adult neuroscience studies suggests that social interaction may alter neural processing, but no neuroimaging studies in children have directly examined the effects of live social-interactive context on social cognition. In the current study of middle childhood, we compare the processing of two types of speech: speech that children believed was presented over a real-time audio-feed by a social partner and speech that they believed was recorded. Although in reality all speech was prerecorded, perceived live speech resulted in significantly greater neural activation in regions associated with social cognitive processing. These findings underscore the importance of using ecologically-valid and interactive methods to understand the developing social brain. © The Author (2016). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  6. Development of AIJ Design Analysis and Modules System Version V

    International Nuclear Information System (INIS)

    Yamaguchi, Daisuke

    2017-01-01

    IHI Corp. continues to develop ADAMS system as a steel structure analysis program of nuclear power plant. This paper introduces its latest version, ADAMS-V, with a focus on the development concept, system configuration, and analysis functions. Without changing the reliability of NEWADAMS, which achieved satisfactory results as a structural analysis program for large structures and piping support structures, ADAMS-V abolished command line input and text manipulation on the workstation, enabled intuitive operation via GUI on multiple personal terminals, and switched the analysis input work to the input mainly based on screen display. In addition, it enabled complicated evaluation when multiple loads act on the structure, as well as the evaluation of design evaluation items such as (1) consideration of friction load, (2) local buckling evaluation, (3) architectural hardware evaluation, (4) rigidity evaluation, and (5) welded part evaluation. In addition, it has achieved more efficient work than in the past by forming the common database in collaboration with 3D-CAD shift ISAP and LUNA developed by IHI. (A.O.)

  7. Development and investigation of a CPV module with Cassegrain mirror optics

    Science.gov (United States)

    Dreger, Max; Wiesenfarth, Maike; Kisser, Arne; Schmid, Tobias; Bett, Andreas W.

    2014-09-01

    One approach to concentrate the sunlight in concentrating photovoltaic (CPV) modules is using Cassegrain mirror optics. The advantage is that a passively cooled solar cell can be mounted to a large heat spreader that does not shade the primary optics. In addition, the height of the module, hence weight, can be low. The design was selected on the basis of the results of a design study comparing different CPV module approaches presented in [1]. In this work, we present the development of a new prototype micro dish module. First results of the characterization are shown. Besides of the electrical performance, a machined optics and an injection molded was investigated regarding sensitivity to misalignment errors between the optical elements as well as measurement of the acceptance angle in- and outdoors. The machined optics was used as reference.

  8. A study on development of monitoring and assessment module for sites

    International Nuclear Information System (INIS)

    Park, Se Moon; Yoon, Bong Yo; Kim, Dae Jung; Park, Joo Wan; Kim, Chang Lak

    2006-01-01

    As the development of total management systems for sites along with site environmental information is becoming standard, the system known as the Site Information and Total Environmental database management System (SITES) has been developed over the last two years. The first result was a database management system for storing data obtained from facilities, and a site characterization in addition to an environmental assessment of a site. The SITES database is designed to be effective and practical for use with facility management and safety assessment in relation to Geographic Information Systems. SITES is a total management program, which includes its database, its data analysis system required for site characterization, a safety assessment modeling system and an environment monitoring system. I can contribute to the institutional management of the facility and to its safety reassessment. SITES is composed of two main modules: the SITES Database Module (SDM) and the Monitoring and Assessment (M and A) module. The M and A module is subdivided into two sub-modules: the Safety Assessment System (SAS) and the Site Environmental Monitoring System (SEMS). SAS controls the data (input and output) from the SITES DB for the site safety assessment, whereas SEMS controls the data obtained from the records of the measuring sensors and facilities. The on-line site and environmental monitoring data is managed in SEMS. The present paper introduces the procedure and function of the M and A modules

  9. RSK2 is a modulator of craniofacial development.

    Directory of Open Access Journals (Sweden)

    Virginie Laugel-Haushalter

    Full Text Available BACKGROUND: The RSK2 gene is responsible for Coffin-Lowry syndrome, an X-linked dominant genetic disorder causing mental retardation, skeletal growth delays, with craniofacial and digital abnormalities typically associated with this syndrome. Craniofacial and dental anomalies encountered in this rare disease have been poorly characterized. METHODOLOGY/PRINCIPAL FINDINGS: We examined, using X-Ray microtomographic analysis, the variable craniofacial dysmorphism and dental anomalies present in Rsk2 knockout mice, a model of Coffin-Lowry syndrome, as well as in triple Rsk1,2,3 knockout mutants. We report Rsk mutation produces surpernumerary teeth midline/mesial to the first molar. This highly penetrant phenotype recapitulates more ancestral tooth structures lost with evolution. Most likely this leads to a reduction of the maxillary diastema. Abnormalities of molar shape were generally restricted to the mesial part of both upper and lower first molars (M1. Expression analysis of the four Rsk genes (Rsk1, 2, 3 and 4 was performed at various stages of odontogenesis in wild-type (WT mice. Rsk2 is expressed in the mesenchymal, neural crest-derived compartment, correlating with proliferative areas of the developing teeth. This is consistent with RSK2 functioning in cell cycle control and growth regulation, functions potentially responsible for severe dental phenotypes. To uncover molecular pathways involved in the etiology of these defects, we performed a comparative transcriptomic (DNA microarray analysis of mandibular wild-type versus Rsk2-/Y molars. We further demonstrated a misregulation of several critical genes, using a Rsk2 shRNA knock-down strategy in molar tooth germs cultured in vitro. CONCLUSIONS: This study reveals RSK2 regulates craniofacial development including tooth development and patterning via novel transcriptional targets.

  10. ICRF array module development and optimization for high power density

    International Nuclear Information System (INIS)

    Ryan, P.M.; Swain, D.W.

    1997-02-01

    This report describes the analysis and optimization of the proposed International Thermonuclear Experimental Reactor (ITER) Antenna Array for the ion cyclotron range of frequencies (ICRF). The objectives of this effort were to: (1) minimize the applied radiofrequency rf voltages occurring in vacuum by proper layout and shape of components, limit the component's surface/volumes where the rf voltage is high; (2) study the effects of magnetic insulation, as applied to the current design; (3) provide electrical characteristics of the antenna for the development and analysis of tuning, arc detection/suppression, and systems for discriminating between arcs and edge-localized modes (ELMs); (4) maintain close interface with mechanical design

  11. Development of a Vehicle Awareness Module for Bicycles

    OpenAIRE

    Sequeira, Charlene

    2017-01-01

    Autonomous driving is one of the car industry’s major challenges. The next generation of cars will not be driven by humans, but by the cars themselves. With the increase in the number of self driving cars, the pedestrians and bikers need to be walk and bike carefully. Bikers need to be careful even now, when we have human driven cars. While driving, sometimes a bike can be in the blind spot of the car and hence go unnoticed. In this thesis, a small scale prototype was developed to help the bi...

  12. Radiation effect characterization and test methods of single-chip and multi-chip stacked 16Mbit DRAMs

    International Nuclear Information System (INIS)

    LaBel, K.A.; Gates, M.M.; Moran, A.K.; Kim, H.S.; Seidleck, C.M.; Marshall, P.; Kinnison, J.; Carkhuff, B.

    1996-01-01

    This paper presents radiation effects characterization performed by the NASA Goddard Space Flight Center (GSFC) on spaceflight candidate 16Mbit DRAMs. This includes heavy ion, proton, and Co60 irradiations on single-chip devices as well as proton irradiation of a stacked DRAM module. Lastly, a discussion of test methodology is undertaken

  13. DEVELOPMENT OF A LOW COST INFERENTIAL NATURAL GAS ENERGY FLOW RATE PROTOTYPE RETROFIT MODULE

    Energy Technology Data Exchange (ETDEWEB)

    E. Kelner; D. George; T. Morrow; T. Owen; M. Nored; R. Burkey; A. Minachi

    2005-05-01

    In 1998, Southwest Research Institute began a multi-year project to develop a working prototype instrument module for natural gas energy measurement. The module will be used to retrofit a natural gas custody transfer flow meter for energy measurement, at a cost an order of magnitude lower than a gas chromatograph. Development and evaluation of the prototype energy meter in 2002-2003 included: (1) refinement of the algorithm used to infer properties of the natural gas stream, such as heating value; (2) evaluation of potential sensing technologies for nitrogen content, improvements in carbon dioxide measurements, and improvements in ultrasonic measurement technology and signal processing for improved speed of sound measurements; (3) design, fabrication and testing of a new prototype energy meter module incorporating these algorithm and sensor refinements; and (4) laboratory and field performance tests of the original and modified energy meter modules. Field tests of the original energy meter module have provided results in close agreement with an onsite gas chromatograph. The original algorithm has also been tested at a field site as a stand-alone application using measurements from in situ instruments, and has demonstrated its usefulness as a diagnostic tool. The algorithm has been revised to use measurement technologies existing in the module to measure the gas stream at multiple states and infer nitrogen content. The instrumentation module has also been modified to incorporate recent improvements in CO{sub 2} and sound speed sensing technology. Laboratory testing of the upgraded module has identified additional testing needed to attain the target accuracy in sound speed measurements and heating value.

  14. Development of energy harvesting modules based on piezoceramics

    Energy Technology Data Exchange (ETDEWEB)

    Kulkarni, V.; Waechter, D.; Ben Mrad, R. [Toronto Univ., ON (Canada). Dept. of Mechanical and Industrial Engineering; El-Diraby, T. [Toronto Univ., ON (Canada). Dept. of Civil Engineering; Somayajula, N.; Nemana, S.; Prasad, E. [Sensor Technology Ltd., Collingwood, ON (Canada)

    2009-07-01

    Self-powered devices can overcome the current reliance and limitations of finite-supply batteries. They have potential in developing next-generation wireless electronics for a wide variety of applications such as health monitoring in civil infrastructure, micro-electro-mechanical system (MEMS) sensor arrays for automotive and aerospace applications, and sensor arrays for environmental control. These energy harvesting devices capture the ambient energy surrounding a system and convert it into usable electrical energy. A common method of power harvesting is to convert ambient mechanical vibrations into electricity through the use of piezoelectric materials such as piezoceramics (PZT). This paper highlighted some of the recent developments in piezoceramic energy harvesting along with proposed circuits that can improve the performance of energy harvesters. The successful storage and use of energy generated by various harvesting devices requires the use of specific circuitry to optimize the output from the devices. Energy harvesting circuitry was characterized in terms of energy storage; AC/DC converter; DC-DC step down converter; and non-linear voltage processing. The patent activity and applications on piezoceramic energy harvesting was also summarized. It was concluded that despite significant research, piezoceramic energy harvesting remains an emerging technology that requires considerable advancement before it can be commercially viable. The power generated by current piezoelectric harvesters is too low for many applications. Alternative piezoceramic materials and their characteristics must be investigated. 31 refs., 1 tab., 4 figs.

  15. Developing Reading Comprehension Modules to Facilitate Reading Comprehension among Malaysian Secondary School ESL Students

    Science.gov (United States)

    Javed, Muhammad; Eng, Lin Siew; Mohamed, Abdul Rashid

    2015-01-01

    The study aims to develop a set of 6 Reading Comprehension Modules (RCMs) for Malaysian ESL teachers to facilitate different reading abilities of ESL students effectively. Different skill categories were selected for developing the RCMs. This article describes how and why diverse texts of varying length were adopted and adapted from various…

  16. Accounting Training Module Development to Boost Agriculture Financial Literacy on Palm Farmers

    Science.gov (United States)

    Hasibuan, Henny Triyana; Murwani, Danardana; Widjaja, Sri Umi Mientarti; Witjaksono, Mit

    2017-01-01

    This research aims to develop agriculture accounting training module in order to increase palm oil farmer financial literacy, in this case farmers in Donomulyo, Malang Regency, Indonesia. The method utilized in model development is Design Based Research using the following progression: problem identification, explanation of goals, design and…

  17. Advancing clinical development pathways for new CFTR modulators in cystic fibrosis.

    Science.gov (United States)

    Mayer-Hamblett, Nicole; Boyle, Michael; VanDevanter, Donald

    2016-05-01

    Cystic fibrosis (CF) is a life-shortening genetic disease affecting approximately 70,000 individuals worldwide. Until recently, drug development efforts have emphasised therapies treating downstream signs and symptoms resulting from the underlying CF biological defect: reduced function of the CF transmembrane conductance regulator (CFTR) protein. The current CF drug development landscape has expanded to include therapies that enhance CFTR function by either restoring wild-type CFTR protein expression or increasing (modulating) the function of mutant CFTR proteins in cells. To date, two systemic small-molecule CFTR modulators have been evaluated in pivotal clinical trials in individuals with CF and specific mutant CFTR genotypes that have led to regulatory review and/or approval. Advances in the discovery of CFTR modulators as a promising new class of therapies have been impressive, yet work remains to develop highly effective, disease-modifying modulators for individuals of all CF genotypes. The objectives of this review are to outline the challenges and opportunities in drug development created by systemic genotype-specific CFTR modulators, highlight the advantages of sweat chloride as an established biomarker of CFTR activity to streamline early-phase development and summarise options for later phase clinical trial designs that respond to the adoption of approved genotype-specific modulators into standard of care. An optimal development framework will be needed to move the most promising therapies efficiently through the drug development pipeline and ultimately deliver efficacious and safe therapies to all individuals with CF. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  18. Cost effective second generation AC-modules: Development and testing aspects

    International Nuclear Information System (INIS)

    Islam, Saiful; Woyte, Achim; Belmans, Ronnie; Heskes, Peter; Rooij, P.M.; Hogedoorn, Ron

    2006-01-01

    In the framework of the European research project PV2GO, a new AC-module inverter was developed, taking into account all relevant aspects from a European market's point of view (standards, market, application, and research and development goals). The project goal was to achieve the overall system costs of 3 Euro per Wp for a modular plug-and-play photovoltaic system. For the photovoltaic-module, a standard 130-Wp Eurosolare module was chosen. The research and development (R and D) goal was to develop an advanced DC-control system consisting of a state-of-the-art programmable digital device and an Application Specific Integrated Circuit (ASIC) for the AC-control of the inverter. According to the topology concept, thermal and magnetic designs were optimized with regard to production technology and packaging for large-scale production. The new AC-modules were tested in a number of field-test sites in various parts of Europe and their reliability was assessed through Highly Accelerated Stress Tests. Efficiency and power quality have been tested in the laboratory. Further in the PV2GO project an optimization study of the manufacturing process of the new generation of AC-modules for high volume output was done. Another task was the pre-certification procedure to assure compliance with the European guidelines and standards

  19. Development of RF non-IQ sampling module for Helium RFQ LLRF system

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Hae-Seong; Ahn, Tae-Sung; Kim, Seong-Gu; Kwon, Hyeok-Jung; Kim, Han-Sung; Song, Young-Gi; Seol, Kyung-Tae; Cho, Yong-Sub [KOMAC, Gyeongju (Korea, Republic of)

    2015-05-15

    KOMAC (Korea Multi-purpose Accelerator Complex) has a plan to develop the helium irradiation system. This system includes the Ion source, LEBT, RFQ, MEBT systems to transport helium particles to the target. Especially, the RFQ (Radio Frequency Quadrupole) system should receive the 200MHz RF within 1% amplitude error stability. For supplying stable 200MHz RF to the RFQ, the low-level radio frequency (LLRF) should be controlled by control system. The helium RFQ LLRF control system adopted non- IQ sampling method to sample the analog input RF. Sampled input data will be calculated to get the I, Q values. These I, Q values will be used to monitor the amplitude and phase of the RF signal. In this paper, non-IQ sampling logic and amplitude and phase calculating logic of the FPGA will be introduced. Using Xilinx ISE design suite which is tool for developing the FPGA logic module, non-IQ sampling module and amplitude and phase computing module developed. In the future, PI gain module and frequency error computing module will be developed.

  20. Development of second generation peptides modulating cellular adiponectin receptor responses

    Directory of Open Access Journals (Sweden)

    Laszlo eOtvos

    2014-10-01

    Full Text Available The adipose tissue participates in the regulation of energy homeostasis as an important endocrine organ that secretes a number of biologically active adipokines, including adiponectin. Recently we developed and characterized a first-in-class peptide-based adiponectin receptor agonist by using in vitro and in vivo models of glioblastoma and breast cancer (BC. In the current study, we further explored the effects of peptide ADP355 in additional cellular models and found that ADP355 inhibited chronic myeloid leukemia (CML cell proliferation and renal myofibroblast differentiation with mid-nanomolar IC50 values. According to molecular modeling calculations, ADP355 was remarkably flexible in the global minimum with a turn present in the middle of the peptide. Considering these structural features of ADP355 and the fact that adiponectin normally circulates as multimeric complexes, we developed and tested the activity of a linear branched dimer (ADP399. The dimer exhibited approximately 20-fold improved cellular activity inhibiting K562 CML and MCF-7 cell growth with high pM - low nM relative IC50 values. Biodistribution studies suggested superior tissue dissemination of both peptides after subcutaneous administration relative to intraperitoneal inoculation. After screening of a 397-member adiponectin active site library, a novel octapeptide (ADP400 was designed that counteracted 10-1000 nM ADP355- and ADP399-mediated effects on CML and BC cell growth at nanomolar concentrations. ADP400 induced mitogenic effects in MCF-7 BC cells perhaps due to antagonizing endogenous adiponectin actions or acting as an inverse agonist. While the linear dimer agonist ADP399 meets pharmacological criteria of a contemporary peptide drug lead, the peptide showing antagonist activity (ADP400 at similar concentrations will be an important target validation tool to study adiponectin functions.

  1. Development of second generation peptides modulating cellular adiponectin receptor responses

    Science.gov (United States)

    Otvos, Laszlo; Knappe, Daniel; Hoffmann, Ralf; Kovalszky, Ilona; Olah, Julia; Hewitson, Tim; Stawikowska, Roma; Stawikowski, Maciej; Cudic, Predrag; Lin, Feng; Wade, John; Surmacz, Eva; Lovas, Sandor

    2014-10-01

    The adipose tissue participates in the regulation of energy homeostasis as an important endocrine organ that secretes a number of biologically active adipokines, including adiponectin. Recently we developed and characterized a first-in-class peptide-based adiponectin receptor agonist by using in vitro and in vivo models of glioblastoma and breast cancer (BC). In the current study, we further explored the effects of peptide ADP355 in additional cellular models and found that ADP355 inhibited chronic myeloid leukemia (CML) cell proliferation and renal myofibroblast differentiation with mid-nanomolar IC50 values. According to molecular modeling calculations, ADP355 was remarkably flexible in the global minimum with a turn present in the middle of the peptide. Considering these structural features of ADP355 and the fact that adiponectin normally circulates as multimeric complexes, we developed and tested the activity of a linear branched dimer (ADP399). The dimer exhibited approximately 20-fold improved cellular activity inhibiting K562 CML and MCF-7 cell growth with high pM - low nM relative IC50 values. Biodistribution studies suggested superior tissue dissemination of both peptides after subcutaneous administration relative to intraperitoneal inoculation. After screening of a 397-member adiponectin active site library, a novel octapeptide (ADP400) was designed that counteracted 10-1000 nM ADP355- and ADP399-mediated effects on CML and BC cell growth at nanomolar concentrations. ADP400 induced mitogenic effects in MCF-7 BC cells perhaps due to antagonizing endogenous adiponectin actions or acting as an inverse agonist. While the linear dimer agonist ADP399 meets pharmacological criteria of a contemporary peptide drug lead, the peptide showing antagonist activity (ADP400) at similar concentrations will be an important target validation tool to study adiponectin functions.

  2. Light and gravity signals synergize in modulating plant development

    Science.gov (United States)

    Vandenbrink, Joshua P.; Kiss, John Z.; Herranz, Raul; Medina, F. Javier

    2014-01-01

    Tropisms are growth-mediated plant movements that help plants to respond to changes in environmental stimuli. The availability of water and light, as well as the presence of a constant gravity vector, are all environmental stimuli that plants sense and respond to via directed growth movements (tropisms). The plant response to gravity (gravitropism) and the response to unidirectional light (phototropism) have long been shown to be interconnected growth phenomena. Here, we discuss the similarities in these two processes, as well as the known molecular mechanisms behind the tropistic responses. We also highlight research done in a microgravity environment in order to decouple two tropisms through experiments carried out in the absence of a significant unilateral gravity vector. In addition, alteration of gravity, especially the microgravity environment, and light irradiation produce important effects on meristematic cells, the undifferentiated, highly proliferating, totipotent cells which sustain plant development. Microgravity produces the disruption of meristematic competence, i.e., the decoupling of cell proliferation and cell growth, affecting the regulation of the cell cycle and ribosome biogenesis. Light irradiation, especially red light, mediated by phytochromes, has an activating effect on these processes. Phytohormones, particularly auxin, also are key mediators in these alterations. Upcoming experiments on the International Space Station will clarify some of the mechanisms and molecular players of the plant responses to these environmental signals involved in tropisms and the cell cycle. PMID:25389428

  3. Module and Electronics Developments for the ATLAS ITK Pixel System

    CERN Document Server

    Rummler, Andr{e}; The ATLAS collaboration

    2016-01-01

    The entire tracking system of the ATLAS experiment will be replaced during the LHC Phase II shutdown around 2025 by an all-silicon detector (Inner Tracker, ITk). The pixel detector will be composed by the five innermost layers, instrumented with new sensor and readout electronics technologies to improve the tracking performance and cope with the severe HL-LHC environment in terms of occupancy and radiation. The total area of the new pixel system could measure up to 14 m^2, depending on the final layout choice that is expected to take place in early 2017. Different designs of planar, 3D, CMOS sensors are being investigated to identify the optimal technology for the different pixel layers. In parallel sensor-chip interconnection options are evaluated in collaboration with industrial partners to identify reliable technologies when employing 100-150 μm thin chips. While the new read-out chip is being developed by the RD53 Collaboration, the pixel off detector read-out electronics will be implemented in the frame...

  4. Module and Electronics Developments for the ATLAS ITK Pixel System

    CERN Document Server

    Nellist, Clara; The ATLAS collaboration

    2016-01-01

    ATLAS is preparing for an extensive modification of its detector in the course of the planned HL-LHC accelerator upgrade around 2025 which includes a replacement of the entire tracking system by an all-silicon detector (Inner Tracker, ITk). The five innermost layers of ITk will comprise of a pixel detector built of new sensor and readout electronics technologies to improve the tracking performance and cope with the severe HL-LHC environment in terms of occupancy and radiation. The total area of the new pixel system could measure up to 14 m$^{2}$, depending on the final layout choice that is expected to take place in early 2017. An intense R\\&D activity is taking place in the field of planar, 3D, CMOS sensors to identify the optimal technology for the different pixel layers. In parallel various sensor-chip interconnection options are explored to identify reliable technologies when employing 100-150~$\\mu$m thin chips. While the new read-out chip is being developed by the RD53 Collaboration, the pixel off de...

  5. Development of Green Box sensor module technologies for rail applications

    Energy Technology Data Exchange (ETDEWEB)

    Rey, D.; Breeding, R. [Sandia National Labs., Albuquerque, NM (United States); Hogan, J.; Mitchell, J. [Sandia National Labs., Livermore, CA (United States); McKeen, R.G. [New Mexico Engineering Research Inst., Albuquerque, NM (United States); Brogan, J. [New Mexico Univ., Albuquerque, NM (United States)

    1996-04-01

    Results of a joint Sandia National Laboratories, University of New Mexico, and New Mexico Engineering Research Institute project to investigate an architecture implementing real-time monitoring and tracking technologies in the railroad industry is presented. The work, supported by the New Mexico State Transportation Authority, examines a family of smart sensor products that can be tailored to the specific needs of the user. The concept uses a strap-on sensor package, designed as a value-added component, integrated into existing industry systems and standards. Advances in sensor microelectronics and digital signal processing permit us to produce a class of smart sensors that interpret raw data and transmit inferred information. As applied to freight trains, the sensors` primary purpose is to minimize operating costs by decreasing losses due to theft, and by reducing the number, severity, and consequence of hazardous materials incidents. The system would be capable of numerous activities including: monitoring cargo integrity, controlling system braking and vehicle acceleration, recognizing component failure conditions, and logging sensor data. A cost-benefit analysis examines the loss of revenue resulting from theft, hazardous materials incidents, and accidents. Customer survey data are combined with the cost benefit analysis and used to guide the product requirements definition for a series of specific applications. A common electrical architecture is developed to support the product line and permit rapid product realization. Results of a concept validation, which used commercial hardware and was conducted on a revenue-generating train, are also reported.

  6. Light and gravity signals synergize in modulating plant development

    Directory of Open Access Journals (Sweden)

    Joshua P. Vandenbrink

    2014-10-01

    Full Text Available Tropisms are growth-mediated plant movements that help plants to respond to changes in environmental stimuli. The availability of water and light, as well as the presence of a constant gravity vector, are all environmental stimuli that plants sense and respond to via directed growth movements (tropisms. The plant response to gravity (gravitropism and the response to unidirectional light (phototropism have long been shown to be interconnected growth phenomena. Here, we discuss the similarities in these two processes, as well as the known molecular mechanisms behind the tropistic responses. We also highlight experiments done in a microgravity environment in order to decouple two tropisms through experiments carried out in the absence of a significant unilateral gravity vector. In addition, alteration of gravity, especially the microgravity environment, and light irradiation produce important effects on meristematic cells, the undifferentiated, highly proliferating, totipotent cells which sustain plant development. Microgravity produces the disruption of meristematic competence, i.e. the decoupling of cell proliferation and cell growth, affecting the regulation of cell cycle and ribosome biogenesis. Light irradiation, especially red light, mediated by phytochromes, has an activating effect on these processes. Phytohormones, particularly auxin, are key mediators in these alterations. Upcoming experiments on the International Space Station will clarify some of the unknown mechanisms and molecular players of the plant responses to these environmental signals involved in tropisms and the cell cycle.

  7. Design and development of line type modulators for high impedance electron gun

    Energy Technology Data Exchange (ETDEWEB)

    Dixit, Kavita P.; Tillu, Abhijit; Chavan, Ramchandra; Yadav, Vivek; Sarukte, Hemant, E-mail: kavidi@barc.gov.in [Accelerator and Pulse Power Division, Bhabha Atomic Research Centre, Mumbai (India)

    2014-07-01

    Conventional line type modulators are routinely used for powering pulsed power microwave devices such as magnetrons and klystrons used for radar, medical and scientific applications. The load impedance (operating point) is fairly well defined in these cases, and makes the design of the discharging circuit of the modulator straight forward. This paper describes the Line type modulators that have been developed and being routinely used for powering the Triode Electron Gun of industrial electron linacs. The beam parameters of such guns are user defined and the pulse current varies from few mA to 800mA (typ). The beam energies requirement varies from 40 keV to 80 keV. Hence the impedance offered by the electron gun to the power source (modulator) is not well defined. The load capacitance which is inclusive of the various stray capacitances along with the intrinsic gun capacitance is ∼ 200-400 pF. This capacitance, which depends on the configuration, shunts the load and makes the effective load highly capacitive with the resistive part varying over a wide range. The paper describes the design and development of conventional line type modulators for powering Electron gun load of the type described above. (author)

  8. "Scaffolding" of Action Learning within a Part-Time Management Development Module

    Science.gov (United States)

    Joesbury, Mark

    2015-01-01

    This Account of Practice describes the introduction and development of action learning within a level 5 module of "Communications at Work" delivered as part of a Business & Technology Education Council (BTEC) Professional Certificate in Management (CMS) between 2005/2006 and 2009/2010. This will commence with a personal narrative and…

  9. Development and Implementation of High School Chemistry Modules Using Touch-Screen Technologies

    Science.gov (United States)

    Lewis, Maurica S.; Zhao, Jinhui; Montclare, Jin Kim

    2012-01-01

    Technology was employed to motivate and captivate students while enriching their in-class education. An outreach program is described that involved college mentors introducing touch-screen technology into a high school chemistry classroom. Three modules were developed, with two of them specifically tailored to encourage comprehension of molecular…

  10. Development of a Web-Based 3D Module for Enhanced Neuroanatomy Education.

    Science.gov (United States)

    Allen, Lauren K; Ren, He Zhen; Eagleson, Roy; de Ribaupierre, Sandrine

    2016-01-01

    Neuroanatomy is a challenging subject, with novice medical students often experiencing difficulty grasping the intricate 3D spatial relationships. Most of the anatomical teaching in undergraduate medicine utilizes conventional 2D resources. E-learning technologies facilitate the development of learner-centered educational tools that can be tailored to meet each student's educational needs, and may foster improved learning in neuroanatomy, however this has yet to be examined fully in the literature. An interactive 3D e-learning module was developed to complement gross anatomy laboratory instruction. Incorporating such 3D modules may provide additional support for students in areas of anatomy that are spatially challenging, such as neuroanatomy. Specific anatomical structures and their relative spatial positions to other structures can be clearly defined in the 3D virtual environment from viewpoints that may not readily be available using cadaveric or 2D image modalities. Providing an interactive user interface for the 3D module in which the student controls many factors may enable the student to develop an improved understanding of the spatial relationships. This work outlines the process for the development of a 3D interactive module of the cerebral structures included in the anatomy curriculum for undergraduate medical students in their second year of study.

  11. Development and pilot testing of full-scale membrane distillation modules for deployment of waste heat

    NARCIS (Netherlands)

    Jansen, A.E.; Assink, J.W.; Hanemaaijer, J.H.; Medevoort, J. van; Sonsbeek, E. van

    2013-01-01

    Membrane distillation is an attractive technology for extracting fresh water from seawater. Newly developed modules have been used in pilot tests and bench scale tests to demonstrate the potential of producing excellent product water quality in a single step, little need for water pretreatment and a

  12. Developing an Implementation Plan. The Administration of Career Education: Module 8.

    Science.gov (United States)

    Drier, Harry N., Jr., Ed.; Martinez, Nancy S., Ed.

    The module is one of a series of eight developed to provide inservice education training for administrators of career education programs. An examination of basic scientific planning approaches and procedures is presented to provide the administrator with a basic tool to implement career education. Various scientific management techniques and their…

  13. Developing the fun and educative module in plant morphology and anatomy learning for tenth graders

    Directory of Open Access Journals (Sweden)

    Alfi Suciyati

    2018-03-01

    Full Text Available This research aims to examine the eligibility of and responses from expert media, expert material, practitioners and students’ on the ‘Fun and Educative’ biology module. The module was developed in a fun and educative way presenting various educative games. The research development model is using ADDIE model that consists of five phases: Analysis, Design, Development, Implementation, and Evaluation. The data collection technique employed examination of learning media experts, material experts, practitioners (biology teachers, and students. The data of research was analyzed in descriptive-qualitative and descriptive-qualitative ways. The results of evaluation on the module’s eligibility convey that the learning media expert gave 87.69% with the category of ‘highly eligible’, the material expert gave 86.00% with the category of ‘highly eligible', and the practitioners gave 83.68% with the category of ‘eligible'. The students' responses to questionnaires given related to the developed module gave 90.00% with the category of ‘highly interesting'. Based on the results of examination by the media expert, material expert, practitioners, and students, conclude that the module has fulfilled the criteria of good and eligible learning material and can be used for studying biology.

  14. Documentation of the Oil and Gas Supply Module (OGSM). Appendix, Model developers report

    International Nuclear Information System (INIS)

    1995-01-01

    The Office of Integrated Analysis and Forecasting (OIAF) is required to provide complete model documentation to meet the EIA Model Acceptance Standards. The Documentation for the Oil and Gas Supply Module (OGSM) provides a complete description of the OGSM methodology, structure, and relation to other modules in the National Energy Modeling System (NEMS). This Model Developers Report (MDR) serves as an appendix to the methodology documentation. This report provides an overview of the model and an assessment of the sensitivity of OGSM results to changes in input data or parameters

  15. Development of a novel fast frequency modulation scheme for the JET multi-channel reflectometer

    International Nuclear Information System (INIS)

    Deliyanakis, N.

    1999-10-01

    A novel frequency modulation scheme has been developed for the multi-channel reflectometer used to measure density profiles and density fluctuations on the JET tokamak. This reflectometer normally uses slow frequency sweeping, combined with fixed-frequency operation, to measure the group delay, as well as plasma fluctuations, at 10 different microwave frequencies. The novel scheme uses continuous frequency modulation on a time-scale much faster than that of plasma fluctuations, the main aim being to make the group delay measurement more robust against plasma fluctuations. This paper discusses the theoretical background of the scheme, gives a detailed description of the system, and presents results from plasma measurements. (author)

  16. ATLAS pixel IBL modules construction experience and developments for future upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Gaudiello, A.

    2015-10-01

    The first upgrade of the ATLAS Pixel Detector is the Insertable B-Layer (IBL), installed in May 2014 in the core of ATLAS. Two different silicon sensor technologies, planar n-in-n and 3D, are used. Sensors are connected with the new generation 130 nm IBM CMOS FE-I4 read-out chip via solder bump-bonds. Production quality control tests were set up to verify and rate the performance of the modules before integration into staves. An overview of module design and construction, the quality control results and production yield will be discussed, as well as future developments foreseen for future detector upgrades.

  17. Student-Centered Modules to Support Active Learning in Hydrology: Development Experiences and Users' Perspectives

    Science.gov (United States)

    Tarboton, D. G.; Habib, E. H.; Deshotel, M.; Merck, M. F.; Lall, U.; Farnham, D. J.

    2016-12-01

    Traditional approaches to undergraduate hydrology and water resource education are textbook based, adopt unit processes and rely on idealized examples of specific applications, rather than examining the contextual relations in the processes and the dynamics connecting climate and ecosystems. The overarching goal of this project is to address the needed paradigm shift in undergraduate education of engineering hydrology and water resources education to reflect parallel advances in hydrologic research and technology, mainly in the areas of new observational settings, data and modeling resources and web-based technologies. This study presents efforts to develop a set of learning modules that are case-based, data and simulation driven and delivered via a web user interface. The modules are based on real-world case studies from three regional hydrologic settings: Coastal Louisiana, Utah Rocky Mountains and Florida Everglades. These three systems provide unique learning opportunities on topics such as: regional-scale budget analysis, hydrologic effects of human and natural changes, flashflood protection, climate-hydrology teleconnections and water resource management scenarios. The technical design and contents of the modules aim to support students' ability for transforming their learning outcomes and skills to hydrologic systems other than those used by the specific activity. To promote active learning, the modules take students through a set of highly engaging learning activities that are based on analysis of hydrologic data and model simulations. The modules include user support in the form of feedback and self-assessment mechanisms that are integrated within the online modules. Module effectiveness is assessed through an improvement-focused evaluation model using a mixed-method research approach guiding collection and analysis of evaluation data. Both qualitative and quantitative data are collected through student learning data, product analysis, and staff interviews

  18. Assessing upper limb function in nonambulant SMA patients: development of a new module.

    Science.gov (United States)

    Mazzone, Elena; Bianco, Flaviana; Martinelli, Diego; Glanzman, Allan M; Messina, Sonia; De Sanctis, Roberto; Main, Marion; Eagle, Michelle; Florence, Julaine; Krosschell, Kristin; Vasco, Gessica; Pelliccioni, Marco; Lombardo, Marilena; Pane, Marika; Finkel, Richard; Muntoni, Francesco; Bertini, Enrico; Mercuri, Eugenio

    2011-06-01

    We report the development of a module specifically designed for assessing upper limb function in nonambulant SMA patients, including young children and those with severe contractures. The application of the module to a preschool cohort of 40 children (age 30-48 months) showed that all the items could be completed by 30 months. The module was also used in 45 nonambulant SMA patients (age 30 months to 27 years). Their scores were more variable than in the preschool cohort, ranging from 0 to 18. The magnitude of scores was not related to age (r=-0.19). The upper limb scores had a good correlation with the Hammersmith Functional Motor Scale, r=0.75, but the upper limb function did not always strictly follow the overall gross motor function. These findings suggest that even some of the very weak nonambulant children possess upper limb skills that can be measured. Copyright © 2011 Elsevier B.V. All rights reserved.

  19. Development of a NIM module for time-to-digital conversion

    International Nuclear Information System (INIS)

    Lin Yanchang; Wang Xiaobin; Chen Shaomin; Gao Yuanning; Jiang Chunhua; Qian Wenbin

    2008-01-01

    A developed single slot wide NIM module for time-to-digital conversion (TDC) is presented in this paper. This TDC module consists of a CPLD based double edge trigger counter with logic function circuit, a high speed comparator based NIM-to-TTL logic level converter, a processor ARM based data access and communication control unit, and voltage regulators for power supply. There are two input groups available, separately for accepting start and stop signal between two input ports or just from the same input port in sequence. With a 50 MHz reference clock, the available input ranges from 0 to 81.91 μs, and the resolution can reach 10 ns level. This module was tested in a muon lifetime measurement experiment, showing good linearity, simple configuration, low power consumption, good reliability, low cost, and easy upgrade as well. (authors)

  20. Development and implementation of quality control strategies for CMS silicon strip tracker modules

    CERN Document Server

    Dirkes, Guido

    The LHC will explore physics at the energy frontier and will address many open questions in particle physics, like the search for the Higgs boson or Supersymmetry. For both high resolution track and vertex reconstruction is vital. The CMS silicon tracker consists of 15232 detector modules. Production and assembly of these will span two and a half years period, during which the quality control chain has to ensure functionality and reliability of the modules produced. The CMS group in Karlsruhe will produce and qualify 1600 modules. Therefore automatic test systems are developed and test strategies are worked out. Already during the RnD phase, first prototype tests were performed and some weak points of the design were uncovered. Two test stations are built. One focuses on a fast functionality test, including an active thermal cycle. The other focuses on debugging and repair requirements, including additional test options with lasers, radioactive sources, probes and infrared LEDs. For quality control measuremen...

  1. Development of high-resolution detector module with depth of interaction identification for positron emission tomography

    International Nuclear Information System (INIS)

    Niknejad, Tahereh; Pizzichemi, Marco; Stringhini, Gianluca; Auffray, Etiennette; Bugalho, Ricardo; Da Silva, Jose Carlos; Di Francesco, Agostino; Ferramacho, Luis; Lecoq, Paul; Leong, Carlos; Paganoni, Marco; Rolo, Manuel; Silva, Rui; Silveira, Miguel; Tavernier, Stefaan; Varela, Joao; Zorraquino, Carlos

    2017-01-01

    We have developed a Time-of-flight high resolution and commercially viable detector module for the application in small PET scanners. A new approach to depth of interaction (DOI) encoding with low complexity for a pixelated crystal array using a single side readout and 4-to-1 coupling between scintillators and photodetectors was investigated. In this method the DOI information is estimated using the light sharing technique. The detector module is a 1.53×1.53×15 mm"3 matrix of 8×8 LYSO scintillator with lateral surfaces optically depolished separated by reflective foils. The crystal array is optically coupled to 4×4 silicon photomultipliers (SiPM) array and readout by a high performance front-end ASIC with TDC capability (50 ps time binning). The results show an excellent crystal identification for all the scintillators in the matrix, a timing resolution of 530 ps, an average DOI resolution of 5.17 mm FWHM and an average energy resolution of 18.29% FWHM. - Highlights: • A new method for DOI encoding for PET detectors based on light sharing is proposed. • A prototype module with LYSO scintillator matrix coupled to SiPMs array is produced. • The module has one side readout and 4-to-1 coupling between scintillators and SiPMs. • A compact TOF front-end ASIC is used. • Excellent performances are shown by the prototype module.

  2. Development of high-resolution detector module with depth of interaction identification for positron emission tomography

    Energy Technology Data Exchange (ETDEWEB)

    Niknejad, Tahereh, E-mail: tniknejad@lip.pt [Laboratory of Instrumentation and Experimental Particles Physics, Lisbon (Portugal); Pizzichemi, Marco [University of Milano-Bicocca (Italy); Stringhini, Gianluca [University of Milano-Bicocca (Italy); CERN, Geneve (Switzerland); Auffray, Etiennette [CERN, Geneve (Switzerland); Bugalho, Ricardo; Da Silva, Jose Carlos; Di Francesco, Agostino [Laboratory of Instrumentation and Experimental Particles Physics, Lisbon (Portugal); Ferramacho, Luis [PETsys Electronics, Oeiras (Portugal); Lecoq, Paul [CERN, Geneve (Switzerland); Leong, Carlos [PETsys Electronics, Oeiras (Portugal); Paganoni, Marco [University of Milano-Bicocca (Italy); Rolo, Manuel [Laboratory of Instrumentation and Experimental Particles Physics, Lisbon (Portugal); INFN, Turin (Italy); Silva, Rui [Laboratory of Instrumentation and Experimental Particles Physics, Lisbon (Portugal); Silveira, Miguel [PETsys Electronics, Oeiras (Portugal); Tavernier, Stefaan [PETsys Electronics, Oeiras (Portugal); Vrije Universiteit Brussel (Belgium); Varela, Joao [Laboratory of Instrumentation and Experimental Particles Physics, Lisbon (Portugal); CERN, Geneve (Switzerland); Zorraquino, Carlos [Biomedical Image Technologies Lab, Universidad Politécnica de Madrid (Spain); CIBER-BBN, Universidad Politécnica de Madrid (Spain)

    2017-02-11

    We have developed a Time-of-flight high resolution and commercially viable detector module for the application in small PET scanners. A new approach to depth of interaction (DOI) encoding with low complexity for a pixelated crystal array using a single side readout and 4-to-1 coupling between scintillators and photodetectors was investigated. In this method the DOI information is estimated using the light sharing technique. The detector module is a 1.53×1.53×15 mm{sup 3} matrix of 8×8 LYSO scintillator with lateral surfaces optically depolished separated by reflective foils. The crystal array is optically coupled to 4×4 silicon photomultipliers (SiPM) array and readout by a high performance front-end ASIC with TDC capability (50 ps time binning). The results show an excellent crystal identification for all the scintillators in the matrix, a timing resolution of 530 ps, an average DOI resolution of 5.17 mm FWHM and an average energy resolution of 18.29% FWHM. - Highlights: • A new method for DOI encoding for PET detectors based on light sharing is proposed. • A prototype module with LYSO scintillator matrix coupled to SiPMs array is produced. • The module has one side readout and 4-to-1 coupling between scintillators and SiPMs. • A compact TOF front-end ASIC is used. • Excellent performances are shown by the prototype module.

  3. Development of an e-Learning Research Module Using Multimedia Instruction Approach.

    Science.gov (United States)

    Kowitlawakul, Yanika; Chan, Moon Fai; Tan, Sharon Swee Lin; Soong, Alan Swee Kit; Chan, Sally Wai Chi

    2017-03-01

    Students nowadays feel more comfortable with new technologies, which increase their motivation and, as a result, improve their academic performance. In the last two decades, the use of information communication technology has been increasing in many disciplines in higher education. Online learning or e-learning has been used and integrated into the curriculum around the world. A team of nursing faculty and educational technology specialists have developed an e-learning research module and integrate it into the nursing curriculum. The aim was to assist master of nursing and postgraduate nursing students in developing their research knowledge before and throughout their enrollment in the research course. This e-learning module includes interactive multimedia such as audiovisual presentation, graphical theme, animation, case-based learning, and pretest and posttest for each topic area. The module focuses on three main topic areas: (1) basic research principles (for review), (2) quantitative method, and (3) qualitative method. The e-learning module is an innovative use of the information and communication technology to enhance student engagement and learning outcomes in a local context. This article discusses the development journey, piloting process, including the variety of evaluation perspectives, and the ways in which the results influenced the e-learning resource before its wider distribution.

  4. Development and implementation of quality control strategies for CMS silicon strip tracker modules

    International Nuclear Information System (INIS)

    Dirkes, G.

    2003-01-01

    The CMS group in Karlsruhe is involved in the construction of the silicon trackers end-caps and will produce and qualify the 1 600 modules of ring 5. Therefore automatic test systems for module qualification are developed and test strategies are worked out. For the electrical tests a complete readout system is developed, based on readout modules available within the collaboration and extended by home build modules. These are based on a modular approach with less complex functional units attached to a motherboard and includes key functionalities like clock and trigger generation and their distribution, high and low voltage supply and test signal generation usable with lasers or infrared LEDs. The motherboard is connected to a standard PC, hosting a fast ADC, interface cards to the motherboard and the front-end electronics. Already during the R and D phase of this readout system, first prototype tests were performed and some weak points of the design were uncovered, resulting in changes of the electronics design of the front end hybrids. Two test stations are built. The first one focuses on a fast functionality test, which includes an active thermal cycle with readout at -10 C performed for each individual module. The other test station focuses on debugging and repair requirements. It disposes of sufficient space for a flexible use of the system, including the possibility of additional test options with lasers, radioactive sources, probes and LEDs. For quality control measurements at module level it turned out, that LEDs are of good use: Besides external signal generation by running them in a pulsed way, they can be used for constant illumination of sensors, inducing an artificial leakage current. This led to the discovery of gain losses of complete readout chips induced by shorted AC coupling capacitances of several readout channels, which are called pinholes. Therefore pinholes must be unbonded from the front end preamplifier, which requires faultless

  5. Development and Impact Evaluation of an E-Learning Radiation Oncology Module

    Energy Technology Data Exchange (ETDEWEB)

    Alfieri, Joanne, E-mail: Joanne.alfieri@mail.mcgill.ca [Department of Radiation Oncology, McGill University Health Centre, Montreal, QC (Canada); Portelance, Lorraine; Souhami, Luis [Department of Radiation Oncology, McGill University Health Centre, Montreal, QC (Canada); Steinert, Yvonne; McLeod, Peter [Centre for Medical Education, McGill University, Montreal, QC (Canada); Gallant, Fleure [Department of Radiation Oncology, McGill University Health Centre, Montreal, QC (Canada); Artho, Giovanni [Department of Radiology, McGill University Health Centre, Montreal, QC (Canada)

    2012-03-01

    Purpose: Radiation oncologists are faced with the challenge of irradiating tumors to a curative dose while limiting toxicity to healthy surrounding tissues. This can be achieved only with superior knowledge of radiologic anatomy and treatment planning. Educational resources designed to meet these specific needs are lacking. A web-based interactive module designed to improve residents' knowledge and application of key anatomy concepts pertinent to radiotherapy treatment planning was developed, and its effectiveness was assessed. Methods and Materials: The module, based on gynecologic malignancies, was developed in collaboration with a multidisciplinary team of subject matter experts. Subsequently, a multi-centre randomized controlled study was conducted to test the module's effectiveness. Thirty-six radiation oncology residents participated in the study; 1920 were granted access to the module (intervention group), and 17 in the control group relied on traditional methods to acquire their knowledge. Pretests and posttests were administered to all participants. Statistical analysis was carried out using paired t test, analysis of variance, and post hoc tests. Results: The randomized control study revealed that the intervention group's pretest and posttest mean scores were 35% and 52%, respectively, and those of the control group were 37% and 42%, respectively. The mean improvement in test scores was 17% (p < 0.05) for the intervention group and 5% (p = not significant) for the control group. Retrospective pretest and posttest surveys showed a statistically significant change on all measured module objectives. Conclusions: The use of an interactive e-learning teaching module for radiation oncology is an effective method to improve the radiologic anatomy knowledge and treatment planning skills of radiation oncology residents.

  6. Development and Impact Evaluation of an E-Learning Radiation Oncology Module

    International Nuclear Information System (INIS)

    Alfieri, Joanne; Portelance, Lorraine; Souhami, Luis; Steinert, Yvonne; McLeod, Peter; Gallant, Fleure; Artho, Giovanni

    2012-01-01

    Purpose: Radiation oncologists are faced with the challenge of irradiating tumors to a curative dose while limiting toxicity to healthy surrounding tissues. This can be achieved only with superior knowledge of radiologic anatomy and treatment planning. Educational resources designed to meet these specific needs are lacking. A web-based interactive module designed to improve residents' knowledge and application of key anatomy concepts pertinent to radiotherapy treatment planning was developed, and its effectiveness was assessed. Methods and Materials: The module, based on gynecologic malignancies, was developed in collaboration with a multidisciplinary team of subject matter experts. Subsequently, a multi-centre randomized controlled study was conducted to test the module's effectiveness. Thirty-six radiation oncology residents participated in the study; 1920 were granted access to the module (intervention group), and 17 in the control group relied on traditional methods to acquire their knowledge. Pretests and posttests were administered to all participants. Statistical analysis was carried out using paired t test, analysis of variance, and post hoc tests. Results: The randomized control study revealed that the intervention group's pretest and posttest mean scores were 35% and 52%, respectively, and those of the control group were 37% and 42%, respectively. The mean improvement in test scores was 17% (p < 0.05) for the intervention group and 5% (p = not significant) for the control group. Retrospective pretest and posttest surveys showed a statistically significant change on all measured module objectives. Conclusions: The use of an interactive e-learning teaching module for radiation oncology is an effective method to improve the radiologic anatomy knowledge and treatment planning skills of radiation oncology residents.

  7. Children's Food and Drink Purchasing Behaviour "Beyond the School Gate": The Development of a Survey Module.

    Science.gov (United States)

    Wills, Wendy J; Macdiarmid, Jennie I; Masson, Lindsey F; Bromley, Catherine; Craig, Leone; McNeill, Geraldine

    2013-01-01

    Many children eat a diet which supplies a higher than recommended amount of nonmilk extrinsic sugars and saturated fatty acids. The school setting is often targeted for nutrition intervention as many children consume food at school. In Scotland, attempts have been made to improve the nutritional content of food in schools and attention has now turned to food and drink available "beyond the school gate." This paper describes the development of a module on food and drink purchasing behaviour. The Food Purchasing Module was designed to collect data, for the first time, from a representative sample of children aged 8-16 years about food and drinks purchased on the way to/from school, during break time/free periods, and at lunchtime, from outlets around schools. Cognitive testing of the module highlighted that younger children find self-completion questionnaires problematic. Older children have fewer problems with self-completion questionnaires but many do not follow question routing, which has implications for the delivery of future surveys. Development of this survey module adds much needed evidence about effectively involving children in surveys. Further research exploring food and drinks purchased beyond the school gate is needed to continue to improve the nutritional quality of children's diets.

  8. Designing electronic module based on learning content development system in fostering students’ multi representation skills

    Science.gov (United States)

    Resita, I.; Ertikanto, C.

    2018-05-01

    This study aims to develop electronic module design based on Learning Content Development System (LCDS) to foster students’ multi representation skills in physics subject material. This study uses research and development method to the product design. This study involves 90 students and 6 physics teachers who were randomly chosen from 3 different Senior High Schools in Lampung Province. The data were collected by using questionnaires and analyzed by using quantitative descriptive method. Based on the data, 95% of the students only use one form of representation in solving physics problems. Representation which is tend to be used by students is symbolic representation. Students are considered to understand the concept of physics if they are able to change from one form to the other forms of representation. Product design of LCDS-based electronic module presents text, image, symbolic, video, and animation representation.

  9. Development of Modal Aerosol Module in CAM5 for Biogeochemical Cycles

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xiaohong [Univ. of Wyoming, Laramie, WY (United States)

    2017-11-18

    This project aims at developing new capabilities for the Modal Aerosol Module in the DOE’s E3SM model with the applications to the global biogeochemical cycle. The impacts of the new developments on model simulations of clouds and climate will be examined. There are thee objectives for this project study: Implementing primary marine organic aerosols into the modal aerosol module (MAM) and investigate effects of primary marine organic aerosols on climate in E3SM; Implementing dust speciation in MAM and investigate the effect of dust species on mixed-phase clouds through indirect effects in E3SM; Writing papers documenting the new MAM developments (e.g., MAM4 documentation paper, marine organic aerosol paper, dust speciation); These objectives will be accomplished in collaborations with Drs. Phil Rasch, Steve Ghan, and Susannah Burrows at Pacific Northwest National Laboratory.

  10. Developing a service-learning module for oral health: A needs assessment

    Directory of Open Access Journals (Sweden)

    R Ebrahim

    2017-03-01

    Full Text Available Background. Service learning (SL as a pedagogy in higher education must be differentiated from other services with a primarily philanthropic intent. Dental therapy and oral hygiene students at Sefako Makgatho Health Sciences University, School of Oral Health Sciences, Pretoria, South Africa visit community sites during their 2nd year of study. However, the current curricula would need restructuring for alignment with the espoused pedagogy and standards of SL. Such an SL curriculum design would thus allow for the provision of meaningful services to communities as an integral component of these programmes. Objective. To explore (i perceptions of 2nd-year oral health students; and (ii opinions of academics with regard to the need for an SL module. Methods. Purposive sampling was used to conduct two focus group discussions with academics involved in curriculum development (n=11 and students who had previous exposure to communities (n=10. A survey containing open-ended questions was completed by 9 academics, who would implement the proposed SL module. Frequencies were calculated and data from the open questions were analysed for emergent themes. Results. Most academics (89%, n=8 indicated that working effectively with others as members of a team and developing cultural sensitivity were achievable from an SL module. Two themes emerged from the focus groups, i.e. (i enhanced teaching and learning – students could apply theoretical and clinical training in an authentic setting; and (ii standardisation of training – an SL module would ensure consistency when engaging with communities. Conclusion. The needs assessment was valuable to inform the development and implementation of the SL module.

  11. Analysis of Design of Mixed-Signal Electronic Packaging

    National Research Council Canada - National Science Library

    Pileggi, Lawrence

    1999-01-01

    The objective of this project is to develop innovative algorithms and prototype tools that will help facilitate the design of mixed signal multi-chip modules and packaging in a manner that is similar...

  12. Research and development of system to utilize photovoltaic energy. Survey on the specific purpose modules; Taiyoko hatsuden riyo system no kenkyu kaihatsu. Taiyoto module ni kansuru chosa kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    Tatsuta, M [New Energy and Industrial Technology Development Organization, Tokyo (Japan)

    1994-12-01

    This paper reports the survey results on the specific purpose modules for photovoltaic power generation in fiscal 1994. (1) On the feasibility survey on new application fields, it was clarified that photovoltaic power generation is applicable to extensive areas such as farmland, road, railway and public facility as latent demand sites. (2) On the optimum modules for various specific purposes, the structure, production method, cost estimation and issues of various modules were studied for desert, wasteland, coast, ocean, river, embankment, railway, road, mobile facility and arcade. (3) On the survey on new materials and material development, various conventional materials and materials promising for required performance were surveyed for every application. (4) On the survey on technology trends, the survey members participated in the first international photovoltaic energy conversion conference and the photovoltaic power generation workshop, while the members held the 1st-5th specific purpose module subcommittees. 1 tab.

  13. The Role of Research in Online Curriculum Development: The Case of "EarthLabs" Climate Change and Earth System Modules

    Science.gov (United States)

    McNeal, Karen S.; Libarkin, Julie C.; Ledley, Tamara Shapiro; Bardar, Erin; Haddad, Nick; Elins, Kathy; Dutta, Saranee

    2014-01-01

    This study reports on an effort to illustrate the coupling of educational research with ongoing curriculum development to promote effective and evidence-based online learning. The research findings have been used to inform the "EarthLabs" curriculum development team as they revise existing modules and create new modules, in order to…

  14. Using scale and feather traits for module construction provides a functional approach to chicken epidermal development.

    Science.gov (United States)

    Bao, Weier; Greenwold, Matthew J; Sawyer, Roger H

    2017-11-01

    Gene co-expression network analysis has been a research method widely used in systematically exploring gene function and interaction. Using the Weighted Gene Co-expression Network Analysis (WGCNA) approach to construct a gene co-expression network using data from a customized 44K microarray transcriptome of chicken epidermal embryogenesis, we have identified two distinct modules that are highly correlated with scale or feather development traits. Signaling pathways related to feather development were enriched in the traditional KEGG pathway analysis and functional terms relating specifically to embryonic epidermal development were also enriched in the Gene Ontology analysis. Significant enrichment annotations were discovered from customized enrichment tools such as Modular Single-Set Enrichment Test (MSET) and Medical Subject Headings (MeSH). Hub genes in both trait-correlated modules showed strong specific functional enrichment toward epidermal development. Also, regulatory elements, such as transcription factors and miRNAs, were targeted in the significant enrichment result. This work highlights the advantage of this methodology for functional prediction of genes not previously associated with scale- and feather trait-related modules.

  15. The development of a valid discovery-based learning module to improve students' mathematical connection

    Science.gov (United States)

    Kuneni, Erna; Mardiyana, Pramudya, Ikrar

    2017-08-01

    Geometry is the most important branch in mathematics. The purpose of teaching this material is to develop students' level of thinking for a better understanding. Otherwise, geometry in particular, has contributed students' failure in mathematics examinations. This problem occurs due to special feature in geometry which has complexity of correlation among its concept. This relates to mathematical connection. It is still difficult for students to improve this ability. This is because teachers' lack in facilitating students towards it. Eventhough, facilitating students can be in the form of teaching material. A learning module can be a solution because it consists of series activities that should be taken by students to achieve a certain goal. A series activities in this case is adopted by the phases of discovery-based learning model. Through this module, students are facilitated to discover concept by deep instruction and guidance. It can build the mathematical habits of mind and also strengthen the mathematical connection. Method used in this research was ten stages of research and development proposed by Bord and Gall. The research purpose is to create a valid learning module to improve students' mathematical connection in teaching quadrilateral. The retrieved valid module based on media expert judgment is 2,43 for eligibility chart aspect, 2,60 for eligibility presentation aspect, and 3,00 for eligibility contents aspect. Then the retrieved valid module based on material expert judgment is 3,10 for eligibility content aspect, 2,87 for eligibility presentation aspect, and 2,80 for eligibility language and legibility aspect.

  16. Development and preliminary verification of 2-D transport module of radiation shielding code ARES

    International Nuclear Information System (INIS)

    Zhang Penghe; Chen Yixue; Zhang Bin; Zang Qiyong; Yuan Longjun; Chen Mengteng

    2013-01-01

    The 2-D transport module of radiation shielding code ARES is two-dimensional neutron and radiation shielding code. The theory model was based on the first-order steady state neutron transport equation, adopting the discrete ordinates method to disperse direction variables. Then a set of differential equations can be obtained and solved with the source iteration method. The 2-D transport module of ARES was capable of calculating k eff and fixed source problem with isotropic or anisotropic scattering in x-y geometry. The theoretical model was briefly introduced and series of benchmark problems were verified in this paper. Compared with the results given by the benchmark, the maximum relative deviation of k eff is 0.09% and the average relative deviation of flux density is about 0.60% in the BWR cells benchmark problem. As for the fixed source problem with isotropic and anisotropic scattering, the results of the 2-D transport module of ARES conform with DORT very well. These numerical results of benchmark problems preliminarily demonstrate that the development process of the 2-D transport module of ARES is right and it is able to provide high precision result. (authors)

  17. Test module development to detect the flase call probe pins on microeprocessor test equipment

    Science.gov (United States)

    Tang, L. W.; Ong, N. R.; Mohamad, I. S. B.; Alcain, J. B.; Retnasamy, V.

    2017-09-01

    Probe pins are useful for electrical testing of microelectronic components, printed circuit board assembly (PCBA), microprocessors and other electronic devices due to it provides the conductivity test based on specific device circuit design. During the repeatable test runs, the load of test modules, contact failures and the current conductivity induces layer wear off all the tip of probe pins contact. Contamination will be build-up on probe pins and increased contact resistivity which results of cost loss and time loss for rectifying programs, rectifying testers and exchanging new probe pins. In this study, a resistivity approach will be developed to provide "Testing of Test Probes". The test module based on "Four-wire Ohm measurement" method with two alternative ways of applying power supply, that are 9V from a single power supply and 5V from Arduino UNO power supply were demonstrated to measure the small resistance value of microprocessor probe pin. A microcontroller with VEE Pro software was used to record the measurement data. The accuracy of both test modules were calibrated under different temperature conditions and result shows that 9V from a single power supply test module has higher measurement accuracy.

  18. Development of Hydrogen Separation Module with Structured Catalyst for Use in Membrane Reformer

    International Nuclear Information System (INIS)

    Isamu Yasuda; Tatsuya Tsuneki; Yoshinori Shirasaki; Toru Shimamori; Hidekazu Shigaki; Hiroyuki Tanaka

    2006-01-01

    A new type of hydrogen separation module for use in a membrane reformer was proposed and developed. The new module, what we call MOC (Membrane On Catalyst), was designed to have a membrane of palladium-based alloy prepared on the surface of the tubular structured catalyst that has catalytic activity for steam reforming reaction, thermal expansion matching with the membrane material, proper porosity, mechanical strength and thermal conductivity. The best composition of the structured catalyst was identified in the composites of metallic Ni and YSZ (Yttria-Stabilized Zirconia). A hydrogen separation module was manufactured by electroless plating of Pd with thickness of 7 to 15 microns on the surface of porous sintered tube of Ni-YSZ with an approximate size of 9 mm in diameter and 100 mm in length. The hydrogen permeability measurements have shown hydrogen flux of 25 to 35 cc/min at 550 to 600 C, which is higher than the permeability of the conventional modules using rolled Pd film. (authors)

  19. Evaluation of a personal and professional development module in an undergraduate medical curriculum in India

    Directory of Open Access Journals (Sweden)

    Ramnarayan Komattil

    2016-03-01

    Full Text Available The study aimed at evaluating the personal and professional development (PPD module in the undergraduate medical curriculum in Melaka Manipal Medical College, India. PPD hours were incorporated in the curriculum. A team of faculty members and a faculty coordinator identified relevant topics and students were introduced to topics such as medical humanities, leadership skills, communication skills, ethics, professional behavior, and patient narratives. The module was evaluated using a prevalidated course feedback questionnaire which was administered to three consecutive batches of students from March 2011 to March 2013. To analyze faculty perspectives, one to one in-depth interviews and focus group discussions were conducted by the coordinators with faculty members who conducted the PPD classes. Analysis of the course feedback form revealed that majority (80% of students agreed that the module was well prepared and was "highly relevant" to the profession. Faculty found the topics new and interdisciplinary and there was a sense of sharing responsibility and workload by the faculty. PPD modules are necessary components of the curriculum and help to mould students while they are still acquiescent as they assume their roles as doctors of the future.

  20. Development of 700 pps high-duty-cycle line-type pulse modulator

    Energy Technology Data Exchange (ETDEWEB)

    Baba, H.; Satoh, K.; Miura, A. [NIHON KOSHUHA Co., LTD., Yokohama, Kanagawa (Japan)] [and others

    1997-04-01

    The high-duty-cycle line-type pulse modulator has been developed to drive the 5.5 MW S-band klystron at the 700 pps maximum repetition-rate and the 14 {mu}sec flat-top pulse-width. To keep an enough recovery time to the thyratron-tube, the command charging scheme was adopted. To do this, a charging SCR-bank has been developed, which is capable of handling the peak charging current of 50 A. The system achieved the world wide highest average output-power of 205 kW. Two modulators have been installed in a new high-duty-cycle electron linear accelerator, which has been started its business operation in March 1996 as an electron-beam-sterilization facility. (J.P.N)

  1. Development of Ultrasonic Modulation Probe for Fluorescence Tomography Based on Acousto-Optic Effect

    Directory of Open Access Journals (Sweden)

    Trinh Quang Duc

    2011-01-01

    Full Text Available We have developed an ultrasonic probe for fluorescence modulation to image fluorescence within biological tissues. The probe consists of a focused ultrasonic transducer mounted on actuators for mechanical fan scanning, which can be used in contact with the measuring object aiming for clinical application. The mechanical fan scanning employed in the probe has a beneficial feature of portability. As a result, fluorescent beads, which were localized with the diameter of 2 mm at 20 mm depth in a pork meat tissue, were detected with resolution of 3 mm. The system performance denotes the feasibility of development towards the final goal of ultrasonic fluorescence modulation tomography for clinical applications.

  2. A Development of the Calibration Tool Applied on Analog I/O Modules for Safety-related Controller

    International Nuclear Information System (INIS)

    Kim, Jong-Kyun; Yun, Dong-Hwa; Lee, Myeong-Kyun; Yoo, Kwan-Woo

    2016-01-01

    The purpose of this paper is to develop the calibration tool for analog input/output(I/O) modules. Those modules are components in POSAFE-Q which is a programmable logic controller(PLC) that has been developed for the evaluation of safety-related. In this paper, performance improvement of analog I/O modules is presented by developing and applying the calibration tool for each channel in analog I/O modules. With this tool, the input signal to an analog input module and the output signal from an analog output module are able to be satisfied with a reference value of sensor type and an accuracy of all modules. With RS-232 communication, the manual calibration tool is developed for analog I/O modules of an existing and up-to-date version in POSAFE-Q PLC. As a result of applying this tool, the converted value is performant for a type of input sensor and an accuracy of analog I/O modules

  3. Module-based Simulation System for efficient development of nuclear simulation programs

    International Nuclear Information System (INIS)

    Yoshikawa, Hidekazu; Wakabayashi, Jiro

    1990-01-01

    Module-based Simulation System (MSS) has been developed to realize a new software environment enabling versatile dynamic simulation of a complex nuclear power plant system flexibly. Described in the paper are (i) fundamental methods utilized in MMS and its software systemization, (ii) development of human interface system to help users in generating integrated simulation programs automatically, and (iii) development of an intelligent user support system for helping users in the two phases of automatical semantic diagnosis and consultation to automatic input data setup for the MSS-generated programs. (author)

  4. Development of the severe accident management guidance module for the SATS training simulator

    International Nuclear Information System (INIS)

    Kim, K. R.; Park, S. H.; Kim, D. H.

    2004-01-01

    Recently KAERI has developed severe accident management guidance to establish Korea standard severe accident management system. On the other hand PC-based severe accident training simulator SATS has been developed, which uses MELCOR computing code as the simulation engine. SATS graphically displays and simulates the severe accident progression with interactive user inputs. The control capability of SATS makes a severe accident training course more interesting and effective. In this paper the development and functions of HyperKAMG module are explained. Furthermore easiness and effectiveness of the HyperKAMG-SATS system in severe accident management are described

  5. Development of module-based simulation system for nuclear power plant

    International Nuclear Information System (INIS)

    Yoshikawa, H.

    1990-01-01

    Module-based Simulation System (MSS) has been developed to realize a new software environment enabling versatile dynamic simulation of a complex nuclear power plant system flexibly. Described in the paper are (i) fundamental methods utilized in MMS and its software systemization, (ii) development of human interface system to help users in generating integrated simulation programs automatically, and (iii) development of an intelligent user support system for helping users in the two phases of automatical semantic diagnosis and consultation to automatic input data setup for the MSS-generated programs

  6. DEVELOPMENT OF PROGRAM MODULE FOR CALCULATING SPEED OF TITANIC PLASMA SEDIMENTATION IN ENVIRONMENT OF TECHNOLOGICAL GAS

    Directory of Open Access Journals (Sweden)

    S. A. Ivaschenko

    2006-01-01

    Full Text Available The program module has been developed on the basis of package of applied MATLAB programs which allows to calculate speed of coating sedimentation over the section of plasma stream taking into account magnetic field influence of a stabilizing coil, and also to correct the obtained value of sedimentation speed depending on the value of negative accelerating potential, arch current, technological gas pressure. The program resolves visualization of calculation results.

  7. Development of assay platforms for in vitro screening of Treg modulating potential of pharmacological compounds

    DEFF Research Database (Denmark)

    Pedersen, Anders Elm; Holmstrøm, Kim; Jørgensen, Flemming

    2015-01-01

    that investigates Treg modulation by current drugs. For such research as well as for novel cell based therapies based on Treg infusions, rapid in vitro assays as well as functional assays based on inhibitory capacity of Tregs are required. Here, we report on such assays using highly pure fluorescence-activated cell...... and TNF-α. In conclusion, these assays have the potential for use in pharmacological screening and discovery in relation to drug development in immunology....

  8. Development of a multifunction module for the neutron electric dipole moment experiment at PSI

    Energy Technology Data Exchange (ETDEWEB)

    Bourrion, O., E-mail: olivier.bourrion@lpsc.in2p3.fr [Laboratoire de Physique Subatomique et de Cosmologie, Université Joseph Fourier Grenoble 1, CNRS/IN2P3, Institut Polytechnique de Grenoble, 53, Rue des Martyrs, Grenoble (France); Pignol, G. [Laboratoire de Physique Subatomique et de Cosmologie, Université Joseph Fourier Grenoble 1, CNRS/IN2P3, Institut Polytechnique de Grenoble, 53, Rue des Martyrs, Grenoble (France); Rebreyend, D. [Laboratoire de Physique Subatomique et de Cosmologie, Université Joseph Fourier Grenoble 1, CNRS/IN2P3, Institut Polytechnique de Grenoble, 53, Rue des Martyrs, Grenoble (France); Paul Scherrer Institut (PSI), CH-5232 Villigen PSI (Switzerland); Vescovi, C. [Laboratoire de Physique Subatomique et de Cosmologie, Université Joseph Fourier Grenoble 1, CNRS/IN2P3, Institut Polytechnique de Grenoble, 53, Rue des Martyrs, Grenoble (France)

    2013-02-11

    Experiments aiming at measuring the neutron electric dipole moment (nEDM) are at the forefront of precision measurements and demand instrumentation of increasing sensitivity and reliability. In this paper, we report on the development of a dedicated acquisition and control electronics board for the nEDM experiment at the Paul Scherrer Institute (PSI) in Switzerland. This multifunction module is based on a FPGA (Field Programmable Gate Array) which allows an optimal combination of versatility and evolution capacities.

  9. Development of Web-Based Common Cause Failure (CCF) Database Module for Nuclear Power Plants

    International Nuclear Information System (INIS)

    Lee, Hyun-Gyo; Hwang, Seok-Won; Shin, Tae-young

    2015-01-01

    Probabilistic safety assessment (PSA) has been used to identify risk vulnerabilities and derive the safety improvement measures from construction to operation stages of nuclear power plants. In addition, risk insights from PSA can be applied to improve the designs and operation requirements of plants. However, reliability analysis methods for quantitative PSA evaluation have essentially inherent uncertainties, and it may create a distorted risk profiles because of the differences among the PSA models, plant designs, and operation status. Therefore, it is important to ensure the quality of the PSA model so that analysts identify design vulnerabilities and utilize risk information. Especially, the common cause failure (CCF) has been pointed out as one of major issues to be able to cause the uncertainty related to the PSA analysis methods and data because CCF has a large influence on the PSA results. Organization for economic cooperation and development /nuclear energy agent (OECD/NEA) has implemented an international common cause failure data exchange (ICDE) project for the CCF quality assurance through the development of the detailed analysis methodologies and data sharing. However, Korea Hydro and Nuclear Power company (KHNP) does not have the basis for the data gathering and analysis for CCF analyses. In case of methodology, the Alpha Factor parameter estimation, which can analyze uncertainties and estimate an interface factor (Impact Vector) with an ease, is ready to be applied rather than the Multi Greek Letter (MGL) method. This article summarizes the development of the plant-specific CCF database (DB) module considering the raw data collection and the analysis procedure based on the CCF parameter calculation method of ICDE. Although the portion affected by CCF in the PSA model is quite a large, the development efforts of the tools to collect and analyze data were insufficient. Currently, KHNP intends to improve PSA quality and ensure CCF data reliability by

  10. Development of Web-Based Common Cause Failure (CCF) Database Module for Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyun-Gyo; Hwang, Seok-Won; Shin, Tae-young [Korea Hydro and Nuclear Power Co. Ltd., Daejeon (Korea, Republic of)

    2015-05-15

    Probabilistic safety assessment (PSA) has been used to identify risk vulnerabilities and derive the safety improvement measures from construction to operation stages of nuclear power plants. In addition, risk insights from PSA can be applied to improve the designs and operation requirements of plants. However, reliability analysis methods for quantitative PSA evaluation have essentially inherent uncertainties, and it may create a distorted risk profiles because of the differences among the PSA models, plant designs, and operation status. Therefore, it is important to ensure the quality of the PSA model so that analysts identify design vulnerabilities and utilize risk information. Especially, the common cause failure (CCF) has been pointed out as one of major issues to be able to cause the uncertainty related to the PSA analysis methods and data because CCF has a large influence on the PSA results. Organization for economic cooperation and development /nuclear energy agent (OECD/NEA) has implemented an international common cause failure data exchange (ICDE) project for the CCF quality assurance through the development of the detailed analysis methodologies and data sharing. However, Korea Hydro and Nuclear Power company (KHNP) does not have the basis for the data gathering and analysis for CCF analyses. In case of methodology, the Alpha Factor parameter estimation, which can analyze uncertainties and estimate an interface factor (Impact Vector) with an ease, is ready to be applied rather than the Multi Greek Letter (MGL) method. This article summarizes the development of the plant-specific CCF database (DB) module considering the raw data collection and the analysis procedure based on the CCF parameter calculation method of ICDE. Although the portion affected by CCF in the PSA model is quite a large, the development efforts of the tools to collect and analyze data were insufficient. Currently, KHNP intends to improve PSA quality and ensure CCF data reliability by

  11. Model developer`s appendix to the model documentation report: NEMS macroeconomic activity module

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-07-15

    The NEMS Macroeconomic Activity Module (MAM) tested here was used to generate the Annual Energy Outlook 1994 (AEO94). MAM is a response surface model, not a structural model, composed of three submodules: the National Submodule, the Interindustry Submodule, and the Regional Submodule. Contents of this report are as follows: properties of the mathematical solution; NEMS MAM empirical basis; and scenario analysis. Scenario analysis covers: expectations for scenario analysis; historical world oil price scenario; AEO94 high world oil price scenario; AEO94 low world oil price scenario; and immediate increase world oil price scenario.

  12. Report on achievements in fiscal 1998. Development of technologies to put photovoltaic power generation systems into practical use - Development of solar beam power generation and utilization systems and ancillary technologies (Research and development of building material integrated solar cell modules - modules with new multi-layer structure); 1998 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu seika hokokusho. Taiyoko hatsuden riyo system shuhen gijutsu no kenkyu kaihatsu (shinkenzai ittaigata taiyo denchi module no kenkyu kaihatsu (shinfukuso kozo module))

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    Development is being made on a panel type module that can be used together with an air bubble concrete board (ALC board), and is provided with design characteristics. The development work includes trial fabrication and evaluation of a module with new multi-layer structure, and development of a technology to unitize cells and submodules, and a systematizing method. In the trial fabrication and evaluation, flame retardant and uninflammable modules using fluororesin, and modules with as large area as 4 m{sup 2} were fabricated on a trial basis, in addition to the modules with the basic structure. These modules were given evaluations on such wall material properties as wind pressure resistance, heat and cracking resistance, and fire resistance. In a deformation resistance test considering the integrated use with the ALC board, the developed modules showed a good result. In developing the cells with design characteristics, discussions were given on the inter-cell wiring methods. Development was made on a method to establish a unit structure based on the design and size of a building. In developing the systematization method, the trial fabrication method was applied to a module with lamination structure, a module integrated with the ALC board, and a large-area hollow module to have fabricated the top-light spandrels. (NEDO)

  13. The State of the Art Report on the Development and Manufacturing Technology of Test Blanket Module

    International Nuclear Information System (INIS)

    Lee, J. S.; Jeong, Y. H.; Park, S. Y.; Lee, M. H.; Choi, B. K.; Baek, J. H.; Park, J. Y.; Kim, J. H.; Kim, H. G.; Kim, K. H.

    2006-07-01

    The main objective of the present R and D on breeder blanket is the development of test blanket modules (TBMs) to be installed and tested in International Thermonuclear Experimental Reactor (ITER). In the program of the blanket development, a blanket module test in the ITER is scheduled from the beginning of the ITER operation, and the performance test of TBM in ITER is the most important milestone for the development of the DEMO blanket. The fabrication of TBMs has been required to test the basic performance of the DEMO blanket, i.e., tritium production/recovery, high-grade heat generation and radiation shielding. Therefore, the integration of the TBM systems into ITER has been investigated with the aim to check the safety, reliability and compatibility under nuclear fusion state. For this reason, in the Test Blanket Working Group (TBWG) as an activity of the International Energy Association (IEA), a variety of ITER TBMs have been proposed and investigated by each party: helium-cooled ceramic (WSG-1), helium-cooled LiPb (WSG-2), water-cooled ceramic (WSG-3), self-cooled lithium (WSG-4) and self-cooled molten salt (WSG-5) blanket systems. Because we are still deficient in investigation of TBM development, the need of development became pressing. In this report, for the development of TBM sub-module and mock-up, it is necessary to analyze and examine the state of the art on the development of manufacturing technology of TBM in other countries. And we will be applied as basic data to establish a manufacturing technology

  14. Development of a 3 tesla - 10 Hz pulsed magnet-modulator system

    International Nuclear Information System (INIS)

    Krausse, G.J.; Butterfield, K.B.

    1984-01-01

    In order to support the experimental work done at the Los Alamos Meson Physics Facility new instrumentation and data collection systems of advanced design are developed on a regular basis. Within the instrumentation system for an experiment at LAMPF, The Photo-Excitation of the H - Ion Resonances, there exists a need for a pulsed air-core electromagnet and modulator system. The magnet must be capable of producing a field strength of 0 to 3T in a volume of 3.5 cm 3 . In addition it must be radiation resistant, have a uniform field, operate in a high vacuum with little or no outgassing, and the physical layout of the magnet must provide minimal azimuthal obstruction to both the ion and laser beams. The modulator must be capable of producing up to a 15KA pulse with duration of two μs at a maximum repetition rate of 10 Hz. Modulator layout must be extremely reliable so that data collection time is not lost during the experiment. This paper describes in detail the development of the system

  15. Towards developing high-fidelity simulated learning environment training modules in audiology.

    Science.gov (United States)

    Dzulkarnain, A A; Rahmat, S; Mohd Puzi, N A F; Badzis, M

    2017-02-01

    This discussion paper reviews and synthesises the literature on simulated learning environment (SLE) from allied health sciences, medical and nursing in general and audiology specifically. The focus of the paper is on discussing the use of high-fidelity (HF) SLE and describing the challenges for developing a HF SLE for clinical audiology training. Through the review of the literature, this paper discusses seven questions, (i) What is SLE? (ii) What are the types of SLEs? (iii) How is SLE classified? (iv) What is HF SLE? (v) What types of SLEs are available in audiology and their level of fidelity? (vi) What are the components needed for developing HF SLE? (vii) What are the possible types of HF SLEs that are suitable for audiology training? Publications were identified by structured searches from three major databases PubMed, Web of Knowledge and PsychInfo and from the reference lists of relevant articles. The authors discussed and mapped the levels of fidelity of SLE audiology training modules from the literature and the learning domains involved in the clinical audiology courses. The discussion paper has highlighted that most of the existing SLE audiology training modules consist of either low- or medium-fidelity types of simulators. Those components needed to achieve a HF SLE for audiology training are also highlighted. Overall, this review recommends that the combined approach of different levels and types of SLE could be used to obtain a HF SLE training module in audiology training.

  16. Development of a lower extremity wearable exoskeleton with double compact elastic module: preliminary experiments

    Directory of Open Access Journals (Sweden)

    Y. Long

    2017-08-01

    Full Text Available In this paper, a double compact elastic module is designed and implemented in the lower extremity exoskeleton. The double compact elastic module is composed of two parts, i.e., physical human robot interaction (pHRI measurement and the elastic actuation system (EAS, which are called proximal elastic module (PEM and distal elastic module (DEM respectively. The PEM is used as the pHRI information collection device while the DEM is used as the compliance device. A novel compact parallelogram-like structure based torsional spring is designed and developed. An iterative finite element analysis (FEA based optimization process was conducted to find the optimal parameters in the search space. In the PEM, the designed torsional spring has an outer circle with a diameter of 60 mm and an inner hole with a diameter of 12 mm, while in the DEM, the torsional spring has the outer circle with a diameter of 80 mm and the inner circle with a diameter of 16 mm. The torsional spring in the PEM has a thickness of 5 mm and a weight of 60 g, while that in the DEM has a thickness of 10 mm and a weight of 80 g. The double compact elastic module prototype is embedded in the mechanical joint directly. Calibration experiments were conducted on those two elastic modules to obtain the linear torque versus angle characteristic. The calibration experimental results show that this torsional spring in the PEM has a stiffness of 60.2 Nm rad−1, which is capable of withstanding a maximum torque of 4 Nm, while that in the DEM has a stiffness of 80.2 Nm rad−1, which is capable of withstanding a maximum torque of 30 Nm. The experimental results and the simulation data show that the maximum resultant errors are 6 % for the PEM and 4 % for the DEM respectively. In this paper, an assumed regression algorithm is used to learn the human motion intent (HMI based on the pHRI collection. The HMI is defined as the angular position of the human limb joint. A

  17. Application of high power modulated intense relativistic electron beams for development of Wake Field Accelerator

    International Nuclear Information System (INIS)

    Friedman, M.

    1989-01-01

    This final Progress Report addresses DOE-sponsored research on the development of future high-gradient particle accelerators. The experimental and the theoretical research, which lasted three years, investigated the Two Beam Accelerator (TBA). This high-voltage-gradient accelerator was powered by a modulated intense relativistic electron beam (MIREB) of power >10 10 watts. This research was conceived after a series of successful experiments performed at NRL generating and using MIREBs. This work showed that an RF structure could be built which was directly powered by a modulated intense relativistic electron beam. This structure was then used to accelerate a second electron beam. At the end of the three year project the proof-of-principle accelerator demonstrated the generation of a high current beam of electrons with energy >60 MeV. Scaling laws needed to design practical devices for future applications were also derived

  18. Development of active edge pixel sensors and four-side buttable modules using vertical integration technologies

    CERN Document Server

    INSPIRE-00219560; Moser, H.-G.; Nisius, R.; Richter, R.H.; Terzo, S.; Weigell, P.

    2014-01-01

    We present an R&D activity focused on the development of novel modules for the upgrade of the ATLAS pixel system at the High Luminosity LHC (HL-LHC). The modules consist of n-in-p pixel sensors, 100 or 200 $\\mu$m thick, produced at VTT (Finland) with an active edge technology, which considerably reduces the dead area at the periphery of the device. The sensors are interconnected with solder bump-bonding to the ATLAS FE-I3 and FE-I4 read-out chips, and characterized with radioactive sources and beam tests at the CERN-SPS and DESY. The results of these measurements will be discussed for devices before and after irradiation up to a fluence of $5\\times 10^{15}$ \

  19. Development of prototype luminosity detector modules for future experiments on linear colliders

    CERN Document Server

    AUTHOR|(CDS)2081248; Idzik, Marek

    The main objective of this dissertation is to develop and validate the prototype module of the LumiCal luminosity detector. The dissertation presents the works executed from the first detector concept, through all subsequent R&D stages, ending with the test beam results obtained using the complete detector module. Firstly, the linear electron positron colliders and planned experiments are introduced, together with their role in our understanding of the basis of matter and sensing for the New Physics. The signal extraction from radiation sensors and further signal processing techniques are discussed in chapter 2. Besides the commonly accepted techniques of amplitude and time measurements, a novel readout implementation, utilizing digital signal processing and deconvolution principle, is proposed, and its properties are analyzed in details. The architecture, design, and measurements of the LumiCal readout chain components are presented in chapter 3. A dedicated test setups prepared for their parameterizatio...

  20. Progress on the WOM (Wavelength-shifting optical module) development for IceCube

    Energy Technology Data Exchange (ETDEWEB)

    Hebecker, Dustin [DESY Zeuthen (Germany)

    2015-07-01

    For ongoing studies for the extension of the IceCube neutrino observatory to low energies (PINGU) and high energies the noise rate of the optical modules should be decreased and the effective area increased in order to improve energy resolution and overall sensitivity. The WOM (Wavelength-shifting optical module) targets this points by expanding the capture area while decreasing the size of the PMT and thus decreasing the noise rate. Photons are first captured in an organic wavelength-shifting material (WLS) that is coated on light guiding material to guide the light to two smaller PMTs. This allows to achieve a very large collection area and reduces the noise to the order of 10 Hz in comparison to 600-800 Hz (IceCube DOM). The progress on the necessary WLS paint development and substrate selection will be presented. Also a brief status / outlook on the prototype assembly will be given.

  1. Development of a remotely maintainable radio-frequency module for the Compact Ignition Tokamak

    International Nuclear Information System (INIS)

    Snider, J.D.

    1988-01-01

    The Compact Ignition Tokamak (CIT) will require reliable remote handling (RH) systems to overcome failures in diagnostic and operational equipment. Oak Ridge National laboratory (ORNL) is responsible for the ex-vessel remote maintenance systems for the CIT. Part of this effort is performing remote maintenance demonstrations on replicas of various CIT equipment. To ensure successful RH, the machine must be designed with proven remote maintenance features. In the demonstrations, critical remote maintenance features are tested before actual CIT equipment designs are finalized. Designs and procedures required to remotely remove and install a radio-frequency (rf) module from a modplane port on the tokamak were recently demonstrated at ORNL. This testing identified both successful design features for remote maintenance of the rf module and areas that require further development. 1 ref., 11 figs

  2. THE DEVELOPMENT OF SCIENCE LEARNING MODULE FOR CHILDRENT WITH HEARING IMPAIRMENT

    Directory of Open Access Journals (Sweden)

    Ahmad Marzuqi

    2017-02-01

    Full Text Available There are the absence of teaching materials in accordance with the characteristics and conditions of a hearing impairment children in terms of learning, especially science subjects. The characteristics of hearing impairment children is poor in their vocabularies, so that, the teaching materials emphasizing the visual aspect is necessary. This study used a Research and Development (R & D adapted by the Sugiyono model in order to produce teaching materials in the form of pictorial modules and to test their effectiveness. The result of the research showed that it was a very valid criteria with a score of 97% of the materials experts, 85% of media experts, and 93% of skilled practitioners. The score of the effectiveness of the modules was 75% with the effective criteria.

  3. Space station common module power system network topology and hardware development

    Science.gov (United States)

    Landis, D. M.

    1985-01-01

    Candidate power system newtork topologies for the space station common module are defined and developed and the necessary hardware for test and evaluation is provided. Martin Marietta's approach to performing the proposed program is presented. Performance of the tasks described will assure systematic development and evaluation of program results, and will provide the necessary management tools, visibility, and control techniques for performance assessment. The plan is submitted in accordance with the data requirements given and includes a comprehensive task logic flow diagram, time phased manpower requirements, a program milestone schedule, and detailed descriptions of each program task.

  4. Design development of the Apollo command and service module thrust vector attitude control systems

    Science.gov (United States)

    Peters, W. H.

    1978-01-01

    Development of the Apollo thrust vector control digital autopilot (TVC DAP) was summarized. This is the control system that provided pitch and yaw attitude control during velocity change maneuvers using the main rocket engine on the Apollo service module. A list of ten primary functional requirements for this control system are presented, each being subordinate to a more general requirement appearing earlier on the list. Development process functions were then identified and the essential information flow paths were explored. This provided some visibility into the particular NASA/contractor interface, as well as relationships between the many individual activities.

  5. A Module Experimental Process System Development Unit (MEPSDU). [flat plate solar arrays

    Science.gov (United States)

    1981-01-01

    The development of a cost effective process sequence that has the potential for the production of flat plate photovoltaic modules which meet the price goal in 1986 of 70 cents or less per Watt peak is described. The major accomplishments include (1) an improved AR coating technique; (2) the use of sand blast back clean-up to reduce clean up costs and to allow much of the Al paste to serve as a back conductor; and (3) the development of wave soldering for use with solar cells. Cells were processed to evaluate different process steps, a cell and minimodule test plan was prepared and data were collected for preliminary Samics cost analysis.

  6. Development of Power Supply Management Module for Radio Signal Repeaters of Automatic Metering Reading System in Variable Solar Density Conditions

    Science.gov (United States)

    Kondratjevs, K.; Zabasta, A.; Selmanovs-Pless, V.

    2016-02-01

    In recent years, there has been significant research focus that revolves around harvesting and minimising energy consumption by wireless sensor network nodes. When a sensor node is depleted of energy, it becomes unresponsive and disconnected from the network that can significantly influence the performance of the whole network. The purpose of the present research is to create a power supply management module in order to provide stable operating voltage for autonomous operations of radio signal repeaters, sensors or gateways of WSN. The developed management module is composed of a solar panel, lithium battery and power supply management module. The novelty of the research is the management module, which ensures stable and uninterrupted operations of electronic equipment in various power supply modes in different situations, simultaneously ensuring energy protection and sustainability of the module components. The management module is able to provide power supply of 5 V for electronics scheme independently, without power interruption switching between power sources and power flows in different directions.

  7. Teaching Concepts to Young Children Through Cultural Cooking Experiences. Bilingual/Bicultural Child Development Associate Pilot Project: Module XIV.

    Science.gov (United States)

    Smith, Teresa R.

    This Child Development Associate (CDA) module, the fourteenth in a series of 16, suggests ways concepts can be taught by involving preschool children in carefully planned classroom cooking activities. Designed for bilingual/bicultural preschool teacher trainees, the module provides tips on food preparation as a learning experience. Required…

  8. The Iterative Development and Use of an Online Problem-Based Learning Module for Preservice and Inservice Teachers

    Science.gov (United States)

    Rillero, Peter; Camposeco, Laurie

    2018-01-01

    Teachers' problem-based learning knowledge, abilities, and attitudes are important factors in successful K--12 PBL implementations. This article describes the development and use of a free, online module entitled "Design a Problem-Based Learning Experience." The module production, aligned with theories of andragogy, was a partnership…

  9. Development of CAD-Based Geometry Processing Module for a Monte Carlo Particle Transport Analysis Code

    International Nuclear Information System (INIS)

    Choi, Sung Hoon; Kwark, Min Su; Shim, Hyung Jin

    2012-01-01

    As The Monte Carlo (MC) particle transport analysis for a complex system such as research reactor, accelerator, and fusion facility may require accurate modeling of the complicated geometry. Its manual modeling by using the text interface of a MC code to define the geometrical objects is tedious, lengthy and error-prone. This problem can be overcome by taking advantage of modeling capability of the computer aided design (CAD) system. There have been two kinds of approaches to develop MC code systems utilizing the CAD data: the external format conversion and the CAD kernel imbedded MC simulation. The first approach includes several interfacing programs such as McCAD, MCAM, GEOMIT etc. which were developed to automatically convert the CAD data into the MCNP geometry input data. This approach makes the most of the existing MC codes without any modifications, but implies latent data inconsistency due to the difference of the geometry modeling system. In the second approach, a MC code utilizes the CAD data for the direct particle tracking or the conversion to an internal data structure of the constructive solid geometry (CSG) and/or boundary representation (B-rep) modeling with help of a CAD kernel. MCNP-BRL and OiNC have demonstrated their capabilities of the CAD-based MC simulations. Recently we have developed a CAD-based geometry processing module for the MC particle simulation by using the OpenCASCADE (OCC) library. In the developed module, CAD data can be used for the particle tracking through primitive CAD surfaces (hereafter the CAD-based tracking) or the internal conversion to the CSG data structure. In this paper, the performances of the text-based model, the CAD-based tracking, and the internal CSG conversion are compared by using an in-house MC code, McSIM, equipped with the developed CAD-based geometry processing module

  10. Switching current imbalance mitigation in power modules with parallel connected SiC MOSFETs

    DEFF Research Database (Denmark)

    Beczkowski, Szymon; Jørgensen, Asger Bjørn; Li, Helong

    2017-01-01

    Multichip power modules use parallel connected chips to achieve high current rating. Due to a finite flexibility in a DBC layout, some electrical asymmetries will occur in the module. Parallel connected transistors will exhibit uneven static and dynamic current sharing due to these asymmetries....... Especially important are the couplings between gate and power loops of individual transistors. Fast changing source currents cause gate voltage imbalances yielding uneven switching currents. Equalizing gate voltages seen by paralleled transistors, done by adjusting source bond wires, is proposed...... in this paper. Analysis is performed on an industry standard DBC layout using numerically extracted module parasitics. The method of tuning individual source inductances shows clear improvement in dynamic current balancing and prevents excessive current overshoot during transistors turn-on....

  11. PSpice Modeling Platform for SiC Power MOSFET Modules with Extensive Experimental Validation

    DEFF Research Database (Denmark)

    Ceccarelli, Lorenzo; Iannuzzo, Francesco; Nawaz, Muhammad

    2016-01-01

    to simulate the performance of high current rating (above 100 A), multi-chip SiC MOSFET modules both for static and switching behavior. Therefore, the simulation results have been validated experimentally in a wide range of operating conditions, including high temperatures, gate resistance and stray elements....... The whole process has been repeated for three different modules with voltage rating of 1.2 kV and 1.7 kV, manufactured by three different companies. Lastly, a parallel connection of two modules of the same type has been performed in order to observe the unbalancing and mismatches experimentally......The aim of this work is to present a PSpice implementation for a well-established and compact physics-based SiC MOSFET model, including a fast, experimental-based parameter extraction procedure in a MATLAB GUI environment. The model, originally meant for single-die devices, has been used...

  12. Plant Growth Research for Food Production: Development and Testing of Expandable Tuber Growth Module

    Science.gov (United States)

    Cordova, Brennan A.

    2017-01-01

    Controlled and reliable growth of a variety of vegetable crops is an important capability for manned deep space exploration systems for providing nutritional supplementation and psychological benefits to crew members. Because current systems have been limited to leafy vegetables that require minimal root space, a major goal for these systems is to increase their ability to grow new types of crops, including tuber plants and root vegetables that require a large root space. An expandable root zone module and housing was developed to integrate this capability into the Veggie growth system. The expandable module uses a waterproof, gas-permeable bag with a structure that allows for root space to increase vertically throughout the growth cycle to accommodate for expanding tuber growth, while minimizing the required media mass. Daikon radishes were chosen as an ideal tuber crop for their subterraneous tuber size and rapid growth cycle, and investigations were done to study expanding superabsorbent hydrogels as a potential growth media. These studies showed improved water retention, but restricted oxygen availability to roots with pure gel media. It was determined that these hydrogels could be integrated in lower proportions into standard soil to achieve media expansion and water retention desired. Using the constructed module prototype and ideal gel and soil media mixture, Daikon radishes were grown in the system to test the capability and success of the system through a full growth cycle.

  13. Development of a new lower hybrid antenna module using a poloidal power divider

    International Nuclear Information System (INIS)

    Maebara, Sunao; Seki, Masami; Suganuma, Kazuaki

    1996-07-01

    The antenna using poloidal power divider is an effective method for simplification of Lower Hybrid Current Drive (LHCD) antenna system. This method should allow to reduce the power density in the antenna while maintaining a good flexibility of N parallel spectrum of waves. For this purpose, three types of poloidal power divider which split the power in three, and the 3 x 6 multi-junction module were developed. r.f. properties and outgassing of these components were evaluated using the CEA Cadarache RF Test Facility. A good power dividing ratio of 33 ± 4% was obtained for each of these poloidal dividers, and the reflection coefficient was lower value than 1.5%. For the 3 x 6 multi-junction, reflection coefficient was less than 1.3% and r.f. losses lower than 1.0% were measured. On the other hand, it was found in the scattering matrix analysis that reflection coefficient at plasma has to be less than a few % in order to operate these components under available conditions. In combination with two poloidal power dividers connected to the 3 x 6 multi-junction module, quasi stationary operation for r.f. injection time of 1000 sec at 300 kW was demonstrated under water cooling. In this case, it was found that the outgassing rate is in the lower range of 10 -7 Pam 3 s -1 m -2 within the maximum module temperature of ∼100degC. This report describes the experimental and analytical results of a new lower hybrid (LH) antenna module using the poloidal power divider. (author)

  14. Pulse position modulation for compact all-fiber vehicle laser rangefinder development

    Science.gov (United States)

    Mao, Xuesong; Cheng, Yongzhi; Xiong, Ying; Inoue, Daisuke; Kagami, Manabu

    2017-10-01

    We propose a method for developing small all-fiber vehicle laser rangefinders that is based on pulse position modulation (PPM) and data integration and present a theoretical study on its performance. Compared with spatial coupling, which is employed by most of the current commercial vehicle laser rangefinders, fiber coupling has the advantage that it can guide laser echoes into the interior of a car, so the electronic components following the photodiode can operate in a moderate-temperature environment. However, optical fibers have numerical apertures (NAs), which means that a laser beam from a receiving lens cannot be coupled into an optical fiber if its incident angle exceeds the critical value. Therefore, the effective size of the receiving lens is typically small since it is limited by its focal length and the NA of the fiber, causing the power of the laser echoes gathered by the receiving lens to be insufficient for performing target identification. Instead of increasing the peak transmitting laser power unrestrictedly, PPM and data integration effectively compensate for the low signal-to-noise ratio that results from the effective receiving lens size reduction. We validated the proposed method by conducting numerical simulations and performance analysis. Finally, we compared the proposed method with pseudorandom noise (PN) code modulation and found that, although the two methods perform equally well in single-target measurement scenarios, PPM is more effective than PN code modulation for multitarget measurement. In addition, PPM enables the transmission of laser beams with higher peak powers and requires less computation than PN code modulation does.

  15. Development of a compact 25-channel preamplifier module for Si-pad detectors of the BARC-CPDA

    International Nuclear Information System (INIS)

    Inkar, A.; John, Bency; Vind, R.P.; Kinage, L.; Jangale, R.V.; Biswas, D.C.; Nayak, B.K.

    2011-01-01

    The BARC Charged Particle Detector Array modules use indigenously developed Si pad detectors as their first element. Total number of charge sensitive pre-amplifiers required for the Si-pad detectors is 250. One of the main ideas here is a layout of five pre-amplifiers connected with one Si-pad detector (called a bank of preamplifiers). In the present work, a 25-channel pre-amplifier module that can cater to 5 independent Si-pad detectors, or a five-bank module, has been developed. This module uses pre-amp hybrid chips A1422H from CAEN S.p.A. and is housed in a double width NIM standard box. The module has been tested for performance using proton and ''7Li beams from FOTIA facility, Trombay

  16. TXESS Revolution: Utilizing TERC's EarthLabs Cryosphere Module to Support Professional Development of Texas Teachers

    Science.gov (United States)

    Odell, M.; Ellins, K. K.; Polito, E. J.; Castillo Comer, C. A.; Stocks, E.; Manganella, K.; Ledley, T. S.

    2010-12-01

    TERC’s EarthLabs project provides rigorous and engaging Earth and environmental science labs. Four existing modules illustrate sequences for learning science concepts through data analysis activities and hands-on experiments. A fifth module, developed with NSF, comprises a series of linked inquiry based activities focused on the cryosphere to help students understand concepts around change over time on multiple and embedded time scales. Teachers recruited from the NSF-OEDG-sponsored Texas Earth and Space Science (TXESS) Revolution teacher professional development program conducted a pedagogical review of the Cryosphere EarthLabs module and provided feedback on how well the materials matched high school needs in Texas and were aligned with state and national standards. Five TXESS Revolution teachers field tested the materials in their classrooms and then trained other TXESS Revolution teachers on their implementation during spring and summer 2010. Here we report on the results of PD delivery during the summer 2010 TXESS Revolution summer institute as determined by (1) a set of evaluation instruments that included a pre-post concept map activity to assess changes in workshop teachers’ understanding of the concepts presented, a pre-post test content knowledge test, and a pre-post survey of teachers’ comfort in teaching the Texas Earth and Space Science standards addressed by the module; (2) teacher reflections; and (3) focus group responses. The findings reveal that the teachers liked the module activities and felt they could use them to teach Environmental and Earth Science. They appreciated that the sequence of activities contributed to a deeper understanding and observed that the variety of methods used to present the information accommodates different learning styles. Information about the cryosphere was new to all the teachers. The content knowledge tests reveal that although teachers made appreciable gains, their understanding of cryosphere, how it changes

  17. Development and Assessment of Modules to Integrate Quantitative Skills in Introductory Biology Courses.

    Science.gov (United States)

    Hoffman, Kathleen; Leupen, Sarah; Dowell, Kathy; Kephart, Kerrie; Leips, Jeff

    2016-01-01

    Redesigning undergraduate biology courses to integrate quantitative reasoning and skill development is critical to prepare students for careers in modern medicine and scientific research. In this paper, we report on the development, implementation, and assessment of stand-alone modules that integrate quantitative reasoning into introductory biology courses. Modules are designed to improve skills in quantitative numeracy, interpreting data sets using visual tools, and making inferences about biological phenomena using mathematical/statistical models. We also examine demographic/background data that predict student improvement in these skills through exposure to these modules. We carried out pre/postassessment tests across four semesters and used student interviews in one semester to examine how students at different levels approached quantitative problems. We found that students improved in all skills in most semesters, although there was variation in the degree of improvement among skills from semester to semester. One demographic variable, transfer status, stood out as a major predictor of the degree to which students improved (transfer students achieved much lower gains every semester, despite the fact that pretest scores in each focus area were similar between transfer and nontransfer students). We propose that increased exposure to quantitative skill development in biology courses is effective at building competency in quantitative reasoning. © 2016 K. Hoffman, S. Leupen, et al. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  18. Development of the PedsQL™ Epilepsy Module: Focus group and cognitive interviews.

    Science.gov (United States)

    Follansbee-Junger, Katherine W; Mann, Krista A; Guilfoyle, Shanna M; Morita, Diego A; Varni, James W; Modi, Avani C

    2016-09-01

    Youth with epilepsy have impaired health-related quality of life (HRQOL). Existing epilepsy-specific HRQOL measures are limited by not having parallel self- and parent-proxy versions, having a restricted age range, not being inclusive of children with developmental disabilities, or being too lengthy for use in a clinical setting. Generic HRQOL measures do not adequately capture the idiosyncrasies of epilepsy. The purpose of the present study was to develop items and content validity for the PedsQL™ Epilepsy Module. An iterative qualitative process of conducting focus group interviews with families of children with epilepsy, obtaining expert input, and conducting cognitive interviews and debriefing was utilized to develop empirically derived content for the instrument. Eleven health providers with expertise in pediatric epilepsy from across the country provided feedback on the conceptual model and content, including epileptologists, nurse practitioners, social workers, and psychologists. Ten pediatric patients (age 4-16years) with a diagnosis of epilepsy and 11 parents participated in focus groups. Thirteen pediatric patients (age 5-17years) and 17 parents participated in cognitive interviews. Focus groups, expert input, and cognitive debriefing resulted in 6 final domains including restrictions, seizure management, cognitive/executive functioning, social, sleep/fatigue, and mood/behavior. Patient self-report versions ranged from 30 to 33 items and parent proxy-report versions ranged from 26 to 33 items, with the toddler and young child versions having fewer items. Standardized qualitative methodology was employed to develop the items and content for the novel PedsQL™ Epilepsy Module. The PedsQL™ Epilepsy Module has the potential to enhance clinical decision-making in pediatric epilepsy by capturing and monitoring important patient-identified contributors to HRQOL. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Development of Femtosecond Stimulated Raman Spectroscopy: Stimulated Raman Gain via Elimination of Cross Phase Modulation

    International Nuclear Information System (INIS)

    Jin, Seung Min; Lee, Young Jong; Yu, Jong Wan; Kim, Seong Keun

    2004-01-01

    We have developed a new femtosecond probe technique by using stimulated Raman spectroscopy. The cross phase modulation in femtosecond time scale associated with off-resonant interaction was shown to be eliminated by integrating the transient gain/loss signal over the time delay between the Raman pump pulse and the continuum pulse. The stimulated Raman gain of neat cyclohexane was obtained to demonstrate the feasibility of the technique. Spectral and temporal widths of stimulated Raman spectra were controlled by using a narrow band pass filter. Femtosecond stimulated Raman spectroscopy was proposed as a highly useful probe in time-resolved vibrational spectroscopy

  20. Unilateral deafness in children affects development of multi-modal modulation and default mode networks

    Directory of Open Access Journals (Sweden)

    Vincent eSchmithorst

    2014-03-01

    Full Text Available Monaural auditory input due to congenital or acquired unilateral hearing loss (UHL may have neurobiological effects on the developing brain. Using fMRI, we investigated the effect of UHL on the development of functional brain networks used for cross-modal processing. Children ages 7-12 with moderate or greater unilateral hearing loss of sensorineural origin (UHL-SN; N = 21 and normal-hearing controls (N = 23 performed an fMRI-compatible adaptation of the Token Test involving listening to a sentence such as touched the small green circle and the large blue square and simultaneously viewing an arrow touching colored shapes on a video. Children with right or severe-to-profound UHL-SN displayed smaller activation in a region encompassing the right inferior temporal, middle temporal, and middle occipital gyrus (BA 19/37/39, evidencing differences due to monaural hearing in cross-modal modulation of the visual processing pathway. Children with UHL-SN displayed increased activation in the left posterior superior temporal gyrus, likely the result either of more effortful low-level processing of auditory stimuli or differences in cross-modal modulation of the auditory processing pathway. Additionally, children with UHL-SN displayed reduced deactivation of anterior and posterior regions of the default mode network. Results suggest that monaural hearing affects the development of brain networks related to cross-modal sensory processing and the regulation of the default network during processing of spoken language.

  1. Development of a wireless nonlinear wave modulation spectroscopy (NWMS) sensor node for fatigue crack detection

    Science.gov (United States)

    Liu, Peipei; Yang, Suyoung; Lim, Hyung Jin; Park, Hyung Chul; Ko, In Chang; Sohn, Hoon

    2014-03-01

    Fatigue crack is one of the main culprits for the failure of metallic structures. Recently, it has been shown that nonlinear wave modulation spectroscopy (NWMS) is effective in detecting nonlinear mechanisms produced by fatigue crack. In this study, an active wireless sensor node for fatigue crack detection is developed based on NWMS. Using PZT transducers attached to a target structure, ultrasonic waves at two distinctive frequencies are generated, and their modulation due to fatigue crack formation is detected using another PZT transducer. Furthermore, a reference-free NWMS algorithm is developed so that fatigue crack can be detected without relying on history data of the structure with minimal parameter adjustment by the end users. The algorithm is embedded into FPGA, and the diagnosis is transmitted to a base station using a commercial wireless communication system. The whole design of the sensor node is fulfilled in a low power working strategy. Finally, an experimental verification has been performed using aluminum plate specimens to show the feasibility of the developed active wireless NWMS sensor node.

  2. Development of Automated Production Line Processes for Solar Brightfield Modules: Annual Technical Progress Report, 1 January 2003 -- 30 June 2004

    Energy Technology Data Exchange (ETDEWEB)

    Nowlan, M. J.; Murach, J. M.; Sutherland, S. F.; Miller, D. C.; Moore, S. B.; Hogan, S. J.

    2005-06-01

    This report describes how Spire Corporation is addressing the PV Manufacturing R&D project goals of improving photovoltaic (PV) manufacturing processes and products while reducing costs and providing a technology foundation that supports significant manufacturing scale-up. To accomplish this, we are focusing our efforts on the design of a large-area utility-scale module and the development of the necessary manufacturing techniques and equipment to manufacture such a module in a high-volume production environment. A three-phase program is under way for developing and demonstrating new automated systems for fabricating very large PV modules ideal for use in multi-megawatt grid-connected applications. We designed a large-area 800 W module and we are developing associated module production equipment that will minimize the total installed system cost for utility-scale PV arrays. Unique features of the module design include a cantilevered glass superstrate to reduce the glass thickness a nd internally laminated bypass diodes that simplify internal busing and junction-box designs. Other program activities include the development of automation for solar cell string inspections, string busing, materials lay-up, and lamination; enhancements to the lamination process; and performance testing of large-area modules.

  3. NASA/First Materials Science Research Rack (MSRR-1) Module Inserts Development for the International Space Station

    Science.gov (United States)

    Crouch, Myscha; Carswell, Bill; Farmer, Jeff; Rose, Fred; Tidwell, Paul

    1999-01-01

    The Material Science Research Rack 1 (MSRR-1) of the Material Science Research Facility (MSRF) contains an Experiment Module (EM) being developed collaboratively by NASA and the European Space Agency (ESA). This NASA/ESA EM will accommodate several different removable and replaceable Module Inserts (MIs) which are installed on orbit. Two of the NASA MIs being developed for specific material science investigations are described herein.

  4. Development of an empirical dynamic model for a Nexa PEM fuel cell power module

    Energy Technology Data Exchange (ETDEWEB)

    Soltani, Mehdi; Mohammad Taghi Bathaee, S. [Power Systems Laboratory, Department of Electrical Engineering, K.N. Toosi University of Technology, 16317-14191 Tehran (Iran)

    2010-12-15

    The goal of this study is to develop a fuel cell model which is capable of characterizing fuel cell steady-state performance as well as dynamic behavior. In this paper a new dynamic model of a 1.2 kW Polymer Electrolyte Membrane Fuel Cell (PEMFC) is developed and validated through a series of experiments. The experimental results have been obtained from a Nexa trademark PEM fuel cell power module under different load conditions. Based on this model, a simulator software package has been developed using the MATLAB {sup registered} and Simulink {sup registered} software and simulation results have been carried out. The proposed model exhibits good agreement with experiment results in steady-state and dynamic performance. (author)

  5. Development and Application of High-Content Biological Screening for Modulators of NET Production

    Directory of Open Access Journals (Sweden)

    Ilaria J. Chicca

    2018-03-01

    Full Text Available Neutrophil extracellular traps (NETs are DNA-based antimicrobial web-like structures whose release is predominantly mediated by reactive oxygen species (ROS; their purpose is to combat infections. However, unbalanced NET production and clearance is involved in tissue injury, circulation of auto-antibodies and development of several chronic diseases. Currently, there is lack of agreement regarding the high-throughput methods available for NET investigation. This study, therefore, aimed to develop and optimize a high-content analysis (HCA approach, which can be applied for the assay of NET production and for the screening of compounds involved in the modulation of NET release. A suitable paraformaldehyde fixation protocol was established to enable HCA of neutrophils and NETs. Bespoke and in-built bioinformatics algorithms were validated by comparison with standard low-throughput approaches for application in HCA of NETs. Subsequently, the optimized protocol was applied to high-content screening (HCS of a pharmaceutically derived compound library to identify modulators of NETosis. Of 56 compounds assessed, 8 were identified from HCS for further characterization of their effects on NET formation as being either inducers, inhibitors or biphasic modulators. The effects of these compounds on naïve neutrophils were evaluated by using specific assays for the induction of ROS and NET production, while their modulatory activity was validated in phorbol 12-myristate 13-acetate-stimulated neutrophils. Results indicated the involvement of glutathione reductase, Src family kinases, molecular-target-of-Rapamycin, and mitogen-activated-protein-kinase pathways in NET release. The compounds and pathways identified may provide targets for novel therapeutic approaches for treating NET-associated pathologies.

  6. Developing and investigating a pure Monte-Carlo module for transient neutron transport analysis

    International Nuclear Information System (INIS)

    Mylonakis, Antonios G.; Varvayanni, M.; Grigoriadis, D.G.E.; Catsaros, N.

    2017-01-01

    Highlights: • Development and investigation of a Monte-Carlo module for transient neutronic analysis. • A transient module developed on the open-source Monte-Carlo static code OpenMC. • Treatment of delayed neutrons is inserted. • Simulation of precursors’ decay process is performed. • Transient analysis of simplified test-cases. - Abstract: In the field of computational reactor physics, Monte-Carlo methodology is extensively used in the analysis of static problems while the transient behavior of the reactor core is mostly analyzed using deterministic algorithms. However, deterministic algorithms make use of various approximations mainly in the geometric and energetic domain that may induce inaccuracy. Therefore, Monte-Carlo methodology which generally does not require significant approximations seems to be an attractive candidate tool for the analysis of transient phenomena. One of the most important constraints towards this direction is the significant computational cost; however since nowadays the available computational resources are continuously increasing, the potential use of the Monte-Carlo methodology in the field of reactor core transient analysis seems feasible. So far, very few attempts to employ Monte-Carlo methodology to transient analysis have been reported. Even more, most of those few attempts make use of several approximations, showing the existence of an “open” research field of great interest. It is obvious that comparing to static Monte-Carlo, a straight-forward physical treatment of a transient problem requires the temporal evolution of the simulated neutrons; but this is not adequate. In order to be able to properly analyze transient reactor core phenomena, the proper simulation of delayed neutrons together with other essential extensions and modifications is necessary. This work is actually the first step towards the development of a tool that could serve as a platform for research and development on this interesting but also

  7. The development and preliminary testing of a multimedia patient–provider survivorship communication module for breast cancer survivors

    Science.gov (United States)

    Wen, Kuang-Yi; Miller, Suzanne M.; Stanton, Annette L.; Fleisher, Linda; Morra, Marion E.; Jorge, Alexandra; Diefenbach, Michael A.; Ropka, Mary E.; Marcus, Alfred C.

    2012-01-01

    Objective This paper describes the development of a theory-guided and evidence-based multimedia training module to facilitate breast cancer survivors’ preparedness for effective communication with their health care providers after active treatment. Methods The iterative developmental process used included: (1) theory and evidence-based content development and vetting; (2) user testing; (3) usability testing; and (4) participant module utilization. Results Formative evaluation of the training module prototype occurred through user testing (n = 12), resulting in modification of the content and layout. Usability testing (n = 10) was employed to improve module functionality. Preliminary web usage data (n = 256, mean age = 53, 94.5% White, 75% college graduate and above) showed that 59% of the participants accessed the communication module, for an average of 7 min per login. Conclusion The iterative developmental process was informative in enhancing the relevance of the communication module. Preliminary web usage results demonstrate the potential feasibility of such a program. Practice implications Our study demonstrates survivors’ openness to the use of a web-based communication skills training module and outlines a systematic iterative user and interface program development and testing process, which can serve as a prototype for others considering such an approach. PMID:22770812

  8. The development and preliminary testing of a multimedia patient-provider survivorship communication module for breast cancer survivors.

    Science.gov (United States)

    Wen, Kuang-Yi; Miller, Suzanne M; Stanton, Annette L; Fleisher, Linda; Morra, Marion E; Jorge, Alexandra; Diefenbach, Michael A; Ropka, Mary E; Marcus, Alfred C

    2012-08-01

    This paper describes the development of a theory-guided and evidence-based multimedia training module to facilitate breast cancer survivors' preparedness for effective communication with their health care providers after active treatment. The iterative developmental process used included: (1) theory and evidence-based content development and vetting; (2) user testing; (3) usability testing; and (4) participant module utilization. Formative evaluation of the training module prototype occurred through user testing (n = 12), resulting in modification of the content and layout. Usability testing (n = 10) was employed to improve module functionality. Preliminary web usage data (n = 256, mean age = 53, 94.5% White, 75% college graduate and above) showed that 59% of the participants accessed the communication module, for an average of 7 min per login. The iterative developmental process was informative in enhancing the relevance of the communication module. Preliminary web usage results demonstrate the potential feasibility of such a program. Our study demonstrates survivors' openness to the use of a web-based communication skills training module and outlines a systematic iterative user and interface program development and testing process, which can serve as a prototype for others considering such an approach. Copyright © 2012. Published by Elsevier Ireland Ltd.

  9. Development of contextual teaching and learning based science module for junior high school for increasing creativity of students

    Science.gov (United States)

    Kurniasari, H.; Sukarmin; Sarwanto

    2018-03-01

    The purpose of this research are to analyze the the properness of contextual teaching and learning (CTL)-based science module for Junior High School for increasing students’ creativity and using CTL-based science module to increase students’ learning creativity. Development of CTL-based science module for Junior High School is Research and Development (R&D) using 4D Model consist of 4 steps: define, design, develop, and disseminate. Module is validated by 3 expert validators (Material, media, and language experts), 2 reviewer and 1 peer reviewer. . Based on the results of data analysis, it can be concluded that: the results of the validation, the average score of CTL-based science module is 88.28%, the value exceeded the value of the cut off score of 87.5%, so the media declared eligible for the study. Research shows that the gain creativity class that uses CTL-based science module has a gain of 0.72. Based on the results of the study showed that CTL-based science module effectively promotes creativity of students

  10. Development of a PET detector module incorporating a silicon photodiode array

    International Nuclear Information System (INIS)

    Rosenfeld, A.B.; Takacs, G.J.; Lerch, M.L.F.; Simmonds, P.E.

    2000-01-01

    Full text: We are developing a new Positron Emission Tomography (PET) detection sub-module with depth of interaction capability. The new sub-module is simple and robust to minimise module assembly complications and is completely independent of photomultiplier tubes. The new sub-module has also been designed to maximise its flexibility for easy sub-module coupling so as to form a complete, customised, detection module to be used in PET scanners dedicated to human brain and breast, and small animal studies. Blue enhanced, silicon 8x8 detector arrays are used to read out the scintillation crystals, and form the basis of the new module. The new detectors were designed by the Centre for Medical Radiation Physics (CMRP) at the University of Wollongong in collaboration with the High Energy Physics Department, University of Melbourne and produced by SPO D etector , Ukraine. Complementing the work on the silicon photodetectors, we have also carried out simulations of the propagation of the scintillation light in the crystals, and the effect of crystal dimensions and surface treatment on the distribution of light detected by the photodiode array. The distribution of light over the photodiodes has then been used to test various algorithms for calculating the point of interaction of the gamma ray in the crystal. Simulations of the light propagation show that for a crystal of dimensions 25mm x 25mm x 3mm, it is possible to determine the point of interaction in 2 dimensions with an average accuracy of just over 0.5mm. The resulting photon distribution detected by the array. The surface treatment, while having a large effect on the light output, does not have a great effect on the accuracy. If these dimensions change to 25mm x 25mm x 6mm then the surface conditions have a greater effect on the accuracy. It is possible however, with careful surface treatment, to achieve an accuracy of around 0.6mm, only marginally worse than the case for the 3mm thick crystal. Gamma ray

  11. Development of volume rendering module for real-time visualization system

    International Nuclear Information System (INIS)

    Otani, Takayuki; Muramatsu, Kazuhiro

    2000-03-01

    Volume rendering is a method to visualize the distribution of physical quantities in the three dimensional space from any viewpoint by tracing the ray direction on the ordinary two dimensional monitoring display. It enables to provide the interior information as well as the surfacial one by producing the translucent images. Therefore, it is regarded as a very useful means as well as an important one in the analysis of the computational results of the scientific calculations, although it has, unfortunately, disadvantage to need a large amount of computing time. This report describes algorithm and its performance of the volume rendering soft-ware which was developed as an important functional module in the real-time visualization system PATRAS. This module can directly visualize the computed results on BFC grid. Moreover, it has already realized the speed-up in some parts of the software by the use of a newly developed heuristic technique. This report includes the investigation on the speed-up of the software by parallel processing. (author)

  12. Development of Calculation Module for Intake Retention Functions based on Occupational Intakes of Radionuclides

    Energy Technology Data Exchange (ETDEWEB)

    Noh, Siwan; Kwon, Tae-Eun; Lee, Jai-Ki [Hanyang Univ., Seoul (Korea, Republic of); Lee, Jong-Il; Kim, Jang-Lyul [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    In internal dosimetry, intake retention and excretion functions are essential to estimate intake activity using bioassay sample such as whole body counter, lung counter, and urine sample. Even though ICRP (International Commission on Radiological Protection)provides the functions in some ICRP publications, it is needed to calculate the functions because the functions from the publications are provided for very limited time. Thus, some computer program are generally used to calculate intake retention and excretion functions and estimate intake activity. OIR (Occupational Intakes of Radionuclides) will be published soon by ICRP, which totally replaces existing internal dosimetry models and relevant data including intake retention and excretion functions. Thus, the calculation tool for the functions is needed based on OIR. In this study, we developed calculation module for intake retention and excretion functions based on OIR using C++ programming language with Intel Math Kernel Library. In this study, we developed the intake retention and excretion function calculation module based on OIR using C++ programing language.

  13. Development of Calculation Module for Intake Retention Functions based on Occupational Intakes of Radionuclides

    International Nuclear Information System (INIS)

    Noh, Siwan; Kwon, Tae-Eun; Lee, Jai-Ki; Lee, Jong-Il; Kim, Jang-Lyul

    2014-01-01

    In internal dosimetry, intake retention and excretion functions are essential to estimate intake activity using bioassay sample such as whole body counter, lung counter, and urine sample. Even though ICRP (International Commission on Radiological Protection)provides the functions in some ICRP publications, it is needed to calculate the functions because the functions from the publications are provided for very limited time. Thus, some computer program are generally used to calculate intake retention and excretion functions and estimate intake activity. OIR (Occupational Intakes of Radionuclides) will be published soon by ICRP, which totally replaces existing internal dosimetry models and relevant data including intake retention and excretion functions. Thus, the calculation tool for the functions is needed based on OIR. In this study, we developed calculation module for intake retention and excretion functions based on OIR using C++ programming language with Intel Math Kernel Library. In this study, we developed the intake retention and excretion function calculation module based on OIR using C++ programing language

  14. Development of intelligent interface for simulation execution by module-based simulation system

    International Nuclear Information System (INIS)

    Yoshikawa, Hidekazu; Mizutani, Naoki; Shimoda, Hiroshi; Wakabayashi, Jiro

    1988-01-01

    An intelligent user support for the two phases of simulation execution was newly developed for Module-based Simulation System (MSS). The MSS has been in development as a flexible simulation environment to improve software productivity in complex, large-scale dynamic simulation of nuclear power plant. The AI programing by Smalltalk-80 was applied to materialize the two user-interface programs for (i) semantic diagnosis of the simulation program generated automatically by MSS, and (ii) consultation system by which user can set up consistent numerical input data files necessary for executing a MSS-generated program. Frame theory was utilized in those interface programs to represent the four knowledge bases, which are (i) usage information on module library in MSS and MSS-generated program, and (ii) expertise knowledge on nuclear power plant analysis such as material properties and reactor system configuration. Capabilities of those interface programs were confirmed by some example practice on LMFBR reactor dynamic calculation, and it was demonstrated that the knowledge-based systemization was effective to improve software work environment. (author)

  15. Integrated management data system for radioactive waste repositories (SGI3R) - development of the inventory module

    International Nuclear Information System (INIS)

    Silva, Fabio; Tello, Cledola Cassia O. de

    2011-01-01

    In Brazil, CNEN is responsible for the intermediate and final storage of radioactive waste generated in the country. The CDTN/CNEN coordinates the RBMN Project for the implementation of the National Repository for disposal radioactive waste of low- and intermediate-level. The results of this Project should be presented so that all data being easily retrievable and useful for all institutions involved, including the regulators. To achieve this goal it was developed at the Waste Management Department - SEGRE/CDTN - a management database system, called 'Integrated Management System for the Management of Repository for Radioactive Waste' (SGI3R). The System consists of relational tables, forms and reports, preserving all available information, avoiding duplication of efforts, additional costs, and it will additionally give support to improve the management of RBMN Project. This paper presents a summary of this development with emphasis on the INVENTORY Module. The data from the inventory of disused sealed sources, which are stored in CDTN, were used to test the functionality of this module and of the SGI3R. These sources were categorized according to guidelines of the IAEA, and it was also presented how they should be safely managed over time. (author)

  16. Development and evaluation of learning module on clinical decision-making in Prosthodontics.

    Science.gov (United States)

    Deshpande, Saee; Lambade, Dipti; Chahande, Jayashree

    2015-01-01

    Best practice strategies for helping students learn the reasoning skills of problem solving and critical thinking (CT) remain a source of conjecture, particularly with regard to CT. The dental education literature is fundamentally devoid of research on the cognitive components of clinical decision-making. This study was aimed to develop and evaluate the impact of blended learning module on clinical decision-making skills of dental graduates for planning prosthodontics rehabilitation. An interactive teaching module consisting of didactic lectures on clinical decision-making and a computer-assisted case-based treatment planning software was developed Its impact on cognitive knowledge gain in clinical decision-making was evaluated using an assessment involving problem-based multiple choice questions and paper-based case scenarios. Mean test scores were: Pretest (17 ± 1), posttest 1 (21 ± 2) and posttest 2 (43 ± 3). Comparison of mean scores was done with one-way ANOVA test. There was overall significant difference in between mean scores at all the three points (P posttest 1 > pretest. Blended teaching methods employing didactic lectures on the clinical decision-making as well as computer assisted case-based learning can be used to improve quality of clinical decision-making in prosthodontic rehabilitation for dental graduates.

  17. Lipid environment modulates the development of acute tolerance to ethanol in Caenorhabditis elegans.

    Directory of Open Access Journals (Sweden)

    Jill C Bettinger

    Full Text Available The development of tolerance to a drug at the level of the neuron reflects a homeostatic mechanism by which neurons respond to perturbations of their function by external stimuli. Acute functional tolerance (AFT to ethanol is a fast compensatory response that develops within a single drug session and normalizes neuronal function despite the continued presence of the drug. We performed a genetic screen to identify genes required for the development of acute functional tolerance to ethanol in the nematode C. elegans. We identified mutations affecting multiple genes in a genetic pathway known to regulate levels of triacylglycerols (TAGs via the lipase LIPS-7, indicating that there is an important role for TAGs in the development of tolerance. Genetic manipulation of lips-7 expression, up or down, produced opposing effects on ethanol sensitivity and on the rate of development of AFT. Further, decreasing cholesterol levels through environmental manipulation mirrored the effects of decreased TAG levels. Finally, we found that genetic alterations in the levels of the TAG lipase LIPS-7 can modify the phenotype of gain-of-function mutations in the ethanol-inducible ion channel SLO-1, the voltage- and calcium-sensitive BK channel. This study demonstrates that the lipid milieu modulates neuronal responses to ethanol that include initial sensitivity and the development of acute tolerance. These results lend new insight into studies of alcohol dependence, and suggest a model in which TAG levels are important for the development of AFT through alterations of the action of ethanol on membrane proteins.

  18. Current Status on the Korean Test Blanket Module Development for testing in the ITER

    International Nuclear Information System (INIS)

    Lee, Dong Won; Kim, Suk Kwon; Bae, Young Dug; Yoon, Jae Sung; Jung, Ki Sok

    2010-01-01

    Korea has proposed and designed a Helium Cooled Molten Lithium (HCML) Test Blanket Module (TBM) to be tested in the International Thermonuclear Experimental Reactor (ITER). Ferrite Martensitic (FM) steel is used as the structural material and helium (He) is used as a coolant to cool the first wall (FW) and breeding zone. Liquid lithium (Li) is circulated for a tritium breeding, not for a cooling purpose. Main purpose for developing the TBM is to develop the design technology for DEMO and fusion reactor and it should be proved through the experiment in the ITER with TBM. Therefore, we have developed the design scheme and related codes including the safety analysis for obtain the license to be tested in the ITER. In order to develop and install at the ITER, several technologies were developed in parallel; fabrication, breeder, He cooling, tritium extraction and so on. Figure 1 shows the overall TBM development scheme. In Korea, official strategy for developing the TBM is to participate to other parties' concept such as US and EU ones, in which PbLi (lead lithium eutectic), He, and FM steel were used for liquid breeder, coolant, and structural material, respectively

  19. The AP2/ERF Transcription Factor DRNL Modulates Gynoecium Development and Affects Its Response to Cytokinin

    Directory of Open Access Journals (Sweden)

    Yolanda Durán-Medina

    2017-10-01

    Full Text Available The gynoecium is the female reproductive system in flowering plants. It is a complex structure formed by different tissues, some that are essential for reproduction and others that facilitate the fertilization process and nurture and protect the developing seeds. The coordinated development of these different tissues during the formation of the gynoecium is important for reproductive success. Both hormones and genetic regulators guide the development of the different tissues. Auxin and cytokinin in particular have been found to play important roles in this process. On the other hand, the AP2/ERF2 transcription factor BOL/DRNL/ESR2/SOB is expressed at very early stages of aerial organ formation and has been proposed to be a marker for organ founder cells. In this work, we found that this gene is also expressed at later stages during gynoecium development, particularly at the lateral regions (the region related to the valves of the ovary. The loss of DRNL function affects gynoecium development. Some of the mutant phenotypes present similarities to those observed in plants treated with exogenous cytokinins, and AHP6 has been previously proposed to be a target of DRNL. Therefore, we explored the response of drnl-2 developing gynoecia to cytokinins, and found that the loss of DRNL function affects the response of the gynoecium to exogenously applied cytokinins in a developmental-stage-dependent manner. In summary, this gene participates during gynoecium development, possibly through the dynamic modulation of cytokinin homeostasis and response.

  20. Specification and development of the sharing memory data management module for a nuclear processes simulator

    International Nuclear Information System (INIS)

    Telesforo R, D.

    2003-01-01

    Actually it is developed in the Engineering Faculty of UNAM a simulator of nuclear processes with research and teaching purposes. It consists of diverse modules, included the one that is described in the present work that is the shared memory module. It uses the IPC mechanisms of the UNIX System V operative system, and it was codified with C language. To model the diverse components of the simulator the RELAP code is used. The function of the module is to generate locations of shared memory for to deposit in these the necessary variables for the interaction among the diverse ones processes of the simulator. In its it will be able read and to write the information that generate the running of the simulation program, besides being able to interact with the internal variables of the code in execution time. The graphic unfolding (mimic, pictorials, tendency graphics, virtual instrumentation, etc.) they also obtain information of the shared memory. In turn, actions of the user in interactive unfolding, they modify the segments of shared memory, and the information is sent to the RELAP code to modify the simulation course. The program has two beginning modes: automatic and manual. In automatic mode taking an enter file of RELAP (indta) and it joins in shared memory, the control variables that in this appear. In manual mode the user joins, he reads and he writes the wanted control variables, whenever they exist in the enter file (indta). This is a dynamic mode of interacting with the simulator in a direct way and of even altering the values as when its don't exist in the board elements associated to the variables. (Author)

  1. Development of Reduced Activation Ferritic-Martensitic Steels and fabrication technologies for Indian test blanket module

    Energy Technology Data Exchange (ETDEWEB)

    Raj, Baldev [Indira Gandhi Centre for Atomic Research, Kalpakkam 603 102 (India); Jayakumar, T., E-mail: tjk@igcar.gov.in [Indira Gandhi Centre for Atomic Research, Kalpakkam 603 102 (India)

    2011-10-01

    For the development of Reduced Activation Ferritic-Martensitic Steel (RAFMS), for the Indian Test Blanket Module for ITER, a 3-phase programme has been adopted. The first phase consists of melting and detailed characterization of a laboratory scale heat conforming to Eurofer 97 composition, to demonstrate the capability of the Indian industry for producing fusion grade steel. In the second phase which is currently in progress, the chemical composition will be optimized with respect to tungsten and tantalum for better combination of mechanical properties. Characterization of the optimized commercial scale India-specific RAFM steel will be carried out in the third phase. The first phase of the programme has been successfully completed and the tensile, impact and creep properties are comparable with Eurofer 97. Laser and electron beam welding parameters have been optimized and welding consumables were developed for Narrow Gap - Gas Tungsten Arc welding and for laser-hybrid welding.

  2. Development of welding technologies for the manufacturing of European Tritium Breeder blanket modules

    Energy Technology Data Exchange (ETDEWEB)

    Poitevin, Y., E-mail: yves.poitevin@f4e.europa.eu [Fusion for Energy (F4E), Barcelona (Spain); Aubert, Ph. [CEA Saclay, DEN/DM2S and DEN/DMN, F-91191 Gif-sur-Yvette (France); Diegele, E. [Fusion for Energy (F4E), Barcelona (Spain); Dinechin, G. de [CEA Saclay, DEN/DM2S and DEN/DMN, F-91191 Gif-sur-Yvette (France); Rey, J. [Institut fuer Neutronenphysik und Reaktortechnik, FZK, Karlsruhe (Germany); Rieth, M. [Institut fuer Materialforschung I, FZK, Karlsruhe (Germany); Rigal, E. [CEA Grenoble, DRT/DTH, F-38000 Grenoble (France); Weth, A. von der [Institut fuer Neutronenphysik und Reaktortechnik, FZK, Karlsruhe (Germany); Boutard, J.-L. [European Fusion Development Agreement (EFDA), Garching (Germany); Tavassoli, F. [CEA Saclay, DEN/DM2S and DEN/DMN, F-91191 Gif-sur-Yvette (France)

    2011-10-01

    Europe has developed two reference Tritium Breeder Blankets concepts for a DEMO fusion reactor: the Helium-Cooled Lithium-Lead and the Helium-Cooled Pebble-Bed. Both are using the reduced-activation ferritic-martensitic EUROFER-97 steel as structural material and will be tested in ITER under the form of test blanket modules. The fabrication of their EUROFER structures requires developing welding processes like laser, TIG, EB and diffusion welding often beyond the state-of-the-art. The status of European achievements in this area is reviewed, illustrating the variety of processes and key issues behind retained options, in particular with respect to metallurgical aspects and mechanical properties. Fabrication of mock-ups is highlighted and their characterization and performances with respect to design requirements are reviewed.

  3. Experience on the FMS Communication module Development for an Application to Safety- Critical Communication Network

    Energy Technology Data Exchange (ETDEWEB)

    Son, Kwang Seop; Lee, Jang Soo; Kim, Jung Heon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2009-05-15

    The field bus has been developed for a network system which supports the real-time communication of various controls and automation equipment. It is known for Profibus in the field of a production automation environment. The Profibus standard uses open communication based on the ISO/OSI model. The Probibus standard uses layer 1, layer 2, layer 7. Layer 7 of Probibus FMS(Fieldbus Message Specification) provides a information and the user of a station. The high-level communication of the safety-grade PLC (POSAFE-Q) developed through the KNICS(Korea Nuclear I and C System) project is the FMS This paper describes the design, the configuration, and the test method of the FMS communication module.

  4. Experience on the FMS Communication module Development for an Application to Safety- Critical Communication Network

    International Nuclear Information System (INIS)

    Son, Kwang Seop; Lee, Jang Soo; Kim, Jung Heon

    2009-01-01

    The field bus has been developed for a network system which supports the real-time communication of various controls and automation equipment. It is known for Profibus in the field of a production automation environment. The Profibus standard uses open communication based on the ISO/OSI model. The Probibus standard uses layer 1, layer 2, layer 7. Layer 7 of Probibus FMS(Fieldbus Message Specification) provides a information and the user of a station. The high-level communication of the safety-grade PLC (POSAFE-Q) developed through the KNICS(Korea Nuclear I and C System) project is the FMS This paper describes the design, the configuration, and the test method of the FMS communication module

  5. Development of a new lower hybrid antenna module using a poloidal power divider

    International Nuclear Information System (INIS)

    Maebara, S.; Imai, T.; Seki, M.; Suganuma, K.; Goniche, M.; Bibet, Ph.; Berio, S.; Brossaud, J.; Rey, G.; Tonon, G.

    1997-03-01

    A realistic antenna module using a poloidal divider for lower hybrid current drive (LHCD) experiment, is modelled and fabricated. In this antenna module test II, three types of poloidal dividers, which split the power in 3, are tested. (author)

  6. ANTICIPATORY GUIDANCE MODULE CHANGES THE AUTHORITARITATIVE PARENTING OF PARENTS IN STIMULATING CHILDREN DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    M. Hasinuddin

    2017-04-01

    Full Text Available Introduction: Anticipatory guidance is a method used by nurses to help parents provide the development of behavior change towards a better understanding of their children. The purpose of this study was to analyze the provision modul of anticipatory guidance to parents and their effects on patterns of authoritarian parenting in stimulating development in kindergarten Dharmawanita Bangkalan Regency. Method: The design in this study was experimental pre post test with control group. The population was the parents of students in Dharmawanita Bangkalan kindergarten in 2010. Respondents were 15 people in the treatment group and 15 people in control group who meet the inclusion criteria. Data collected by using a questionnaire. Data then analyzed using Wilcoxon and Mann Whitney test. Result: The result showed that the differences in upbringing the parents before and after the anticipatory guidance given p value of 0.001, whereas in the control group there was no difference with a p value of 0.083. To find out the difference of counselling terms between treatment and control groups were performed by mann whitney test with p-value (0,004 < α (0.05. Discussion: Based on these results we can conclude that modul of anticipatory guidance has an impact on the upbringing of parents in stimulating growth in children in kindergarten Dharmawanita Bangkalan. Research on the effect of anticipatory guidance by the nurse to child development is necessary as a follow up of this research by considering the factors that in fl uence the development of the child itself.

  7. Development of user interface to support automatic program generation of nuclear power plant analysis by module-based simulation system

    International Nuclear Information System (INIS)

    Yoshikawa, Hidekazu; Mizutani, Naoki; Nakaya, Ken-ichiro; Wakabayashi, Jiro

    1988-01-01

    Module-based Simulation System (MSS) has been developed to realize a new software work environment enabling versatile dynamic simulation of a complex nuclear power system flexibly. The MSS makes full use of modern software technology to replace a large fraction of human software works in complex, large-scale program development by computer automation. Fundamental methods utilized in MSS and developmental study on human interface system SESS-1 to help users in generating integrated simulation programs automatically are summarized as follows: (1) To enhance usability and 'communality' of program resources, the basic mathematical models of common usage in nuclear power plant analysis are programed as 'modules' and stored in a module library. The information on usage of individual modules are stored in module database with easy registration, update and retrieval by the interactive management system. (2) Target simulation programs and the input/output files are automatically generated with simple block-wise languages by a precompiler system for module integration purpose. (3) Working time for program development and analysis in an example study of an LMFBR plant thermal-hydraulic transient analysis was demonstrated to be remarkably shortened, with the introduction of an interface system SESS-1 developed as an automatic program generation environment. (author)

  8. Development of an advanced static feed water electrolysis module. [for spacecraft

    Science.gov (United States)

    Schubert, F. H.; Wynveen, R. A.; Jensen, F. C.; Quattrone, P. D.

    1975-01-01

    A Static Feed Water Electrolysis Module (SFWEM) was developed to produce 0.92 kg/day (2.0 lb/day) of oxygen (O2). Specific objectives of the program's scope were to (1) eliminate the need for feed water cavity degassing, (2) eliminate the need for subsystem condenser/separators, (3) increase current density capability while decreasing electrolysis cell power (i.e., cell voltage) requirements, and (4) eliminate subsystem rotating parts and incorporate control and monitor instrumentation. A six-cell, one-man capacity module having an active area of 0.00929 sq m (0.10 sq ft) per cell was designed, fabricated, assembled, and subjected to 111 days (2664 hr) of parametric and endurance testing. The SFWEM was successfully operated over a current density range of 0 to 1076 mA/sq cm (0 to 1000 ASF), pressures of ambient to 2067 kN/sq m (300 psia), and temperatures of ambient to 366 K (200 F). During a 94-day endurance test, the SFWEM successfully demonstrated operation without the need for feed water compartment degassing.

  9. Development and utilization of liquid quartz light modulating film. Ekisho choko film no kaihatsu to riyo

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, M. (Ajinomoto Co. Inc., Tokyo (Japan))

    1992-03-01

    This paper introduces the polymer dispersed liquid crystal (PDLC) ACT'' sheet, a liquid quartz light modulating film, developed by the Ajinomoto Company in Japan. A mixture of liquid crystal and polymer precursor is sandwiched between polyethylene terephthalate films imparted with transparency conductor made of indium tin oxide (ITO), which is then polymerized by heating or irradiating ultraviolet rays to obtain a PDLC. The film has a thickness as thin as about 0.3 mm, and good processibility. The sheet uses light modulating elements functioning on scatter and permeation of light. Clarification was made on the voltage dependence of cloudiness, total light permeability, straight and parallel light permeability, the response, and the operating voltage. The system consumes small amount of power with a threshold value of about 35V, and is suitable to operate large areas when working on the utility power supply. An incident light having a high diffusion capability when the electric field is turned off exhibits a high clouding function. The system gives an excellent feel of colorlessness and transparency when the electric field is turned on. The performances in heat insulation, infrared reflection capability and noise resistance are expected to be compounded for a functional versatility. 4 refs., 6 figs., 2 tabs.

  10. Toward the development of a low-cost laser Doppler module for ophthalmic microscopes

    Science.gov (United States)

    Cattini, Stefano; Rovati, Luigi

    2012-03-01

    A laser Doppler module easily integrated into a commercial ophthalmic microscope is proposed. Such setup adds flow measurement capability to standard visual inspection of the fundus. The proposed instrument may provide important clinical information such as the detection of vessel occlusion provided by surgical treatments (i.e. photocoagulation). The measuring system is based on a self-mixing laser diode Doppler flowmeter (SM-DF). Reduced costs, easy implementation and small size represent the main features of SM-DF. Moreover, this technique offers the advantage to have the excitation and measurement beams spatially overlapped, thus both overcoming the alignment difficulty of traditional laser Doppler flowmeter and, well fitting with to limited optical aperture of the pupil. Thanks to an on-board DSP-microcontroller, the optoelectronic module directly estimates the blood flow; USB connection and an ad-hoc developed user-friendly software interface allow displaying the result on a personal computer. Preliminary test demonstrates the applicability of the proposed measuring system.

  11. Development of an Air-Source Heat Pump Integrated with a Water Heating / Dehumidification Module

    Energy Technology Data Exchange (ETDEWEB)

    Rice, C Keith [ORNL; Uselton, Robert B. [Lennox Industries, Inc; Shen, Bo [ORNL; Baxter, Van D [ORNL; Shrestha, Som S [ORNL

    2014-01-01

    A residential-sized dual air-source integrated heat pump (AS-IHP) concept is under development in partnership between ORNL and a manufacturer. The concept design consists of a two-stage air-source heat pump (ASHP) coupled on the air distribution side with a separate novel water heating/dehumidification (WH/DH) module. The motivation for this unusual equipment combination is the forecast trend for home sensible loads to be reduced more than latent loads. Integration of water heating with a space dehumidification cycle addresses humidity control while performing double-duty. This approach can be applied to retrofit/upgrade applications as well as new construction. A WH/DH module capable of ~1.47 L/h water removal and ~2 kW water heating capacity was assembled by the manufacturer. A heat pump system model was used to guide the controls design; lab testing was conducted and used to calibrate the models. Performance maps were generated and used in a TRNSYS sub-hourly simulation to predict annual performance in a well-insulated house. Annual HVAC/WH energy savings of ~35% are predicted in cold and hot-humid U.S. climates compared to a minimum efficiency baseline.

  12. Development of an MR-compatible DOI-PET detector module

    Energy Technology Data Exchange (ETDEWEB)

    Wei, Qingyang [Department of Electrical Engineering, Tsinghua University, Beijing (China); Key Laboratory of Particle and Radiation Imaging, Ministry of Education (Tsinghua University), Beijing (China); Wang, Shi; Xu, Tianpeng; Gao, Yunpeng; Liu, Yaqiang; Ma, Tianyu [Department of Engineering Physics, Tsinghua University, Beijing (China); Key Laboratory of Particle and Radiation Imaging, Ministry of Education (Tsinghua University), Beijing (China)

    2015-05-18

    Silicon Photomultiplier (SiPM) is a promising sensor for MR-compatible PET systems. In this paper, we developed a compact 2-layer DOI-PET detector. The top layer is a 15×15 LYSO array, and the crystal size is 2x2x7mm{sup 3}. The bottom layer is a 16×16 array with the same size crystals. There is half-crystal offset between two layers in both transverse directions. The detector is coupled to an 8×8 SiPM array (MicroFB-30035-SMT, Sensl). Sixty-four channels of SiPMs are read out by an ASIC chip with in-chip multiplexing resistor networks in the form of two position and one energy analog signals, and are then converted to wave-form digital signals with 80 MHz 12-bit ADC chips. The energy is calculated by averaging the 3 points around the peak of the pulse. Flood images with two 22Na point sources irradiated on the top and at the bottom of the detector module were acquired. The results show that the detector module achieves good crystal identification capability in both layers with an average energy resolution of 17.1% at 511 keV.

  13. Development of active edge pixel sensors and four-side buttable modules using vertical integration technologies

    Energy Technology Data Exchange (ETDEWEB)

    Macchiolo, A., E-mail: Anna.Macchiolo@mpp.mpg.de [Max-Planck-Institut for Physics, Föhringer Ring 6, D-80805 Munich (Germany); Andricek, L. [Semiconductor Laboratory of the Max-Planck-Society, Otto Hahn Ring 6, D-81739 Munich (Germany); Moser, H.-G.; Nisius, R. [Max-Planck-Institut for Physics, Föhringer Ring 6, D-80805 Munich (Germany); Richter, R.H. [Semiconductor Laboratory of the Max-Planck-Society, Otto Hahn Ring 6, D-81739 Munich (Germany); Terzo, S.; Weigell, P. [Max-Planck-Institut for Physics, Föhringer Ring 6, D-80805 Munich (Germany)

    2014-11-21

    We present an R and D activity focused on the development of novel modules for the upgrade of the ATLAS pixel system at the High Luminosity LHC (HL-LHC). The modules consist of n-in-p pixel sensors, 100 or 200 μm thick, produced at VTT (Finland) with an active edge technology, which considerably reduces the dead area at the periphery of the device. The sensors are interconnected with solder bump-bonding to the ATLAS FE-I3 and FE-I4 read-out chips, and characterised with radioactive sources and beam tests at the CERN-SPS and DESY. The results of these measurements will be discussed for devices before and after irradiation up to a fluence of 5×10{sub 15}n{sub eq}/cm{sup 2}. We will also report on the R and D activity to obtain Inter Chip Vias (ICVs) on the ATLAS read-out chip in collaboration with the Fraunhofer Institute EMFT. This step is meant to prove the feasibility of the signal transport to the newly created readout pads on the backside of the chips allowing for four side buttable devices without the presently used cantilever for wire bonding. The read-out chips with ICVs will be interconnected to thin pixel sensors, 75 μm and 150 μm thick, with the Solid Liquid Interdiffusion (SLID) technology, which is an alternative to the standard solder bump-bonding.

  14. Development of an MR-compatible DOI-PET detector module

    International Nuclear Information System (INIS)

    Wei, Qingyang; Wang, Shi; Xu, Tianpeng; Gao, Yunpeng; Liu, Yaqiang; Ma, Tianyu

    2015-01-01

    Silicon Photomultiplier (SiPM) is a promising sensor for MR-compatible PET systems. In this paper, we developed a compact 2-layer DOI-PET detector. The top layer is a 15×15 LYSO array, and the crystal size is 2x2x7mm 3 . The bottom layer is a 16×16 array with the same size crystals. There is half-crystal offset between two layers in both transverse directions. The detector is coupled to an 8×8 SiPM array (MicroFB-30035-SMT, Sensl). Sixty-four channels of SiPMs are read out by an ASIC chip with in-chip multiplexing resistor networks in the form of two position and one energy analog signals, and are then converted to wave-form digital signals with 80 MHz 12-bit ADC chips. The energy is calculated by averaging the 3 points around the peak of the pulse. Flood images with two 22Na point sources irradiated on the top and at the bottom of the detector module were acquired. The results show that the detector module achieves good crystal identification capability in both layers with an average energy resolution of 17.1% at 511 keV.

  15. Development of a Smart Mobile Data Module for Fetal Monitoring in E-Healthcare.

    Science.gov (United States)

    Houzé de l'Aulnoit, Agathe; Boudet, Samuel; Génin, Michaël; Gautier, Pierre-François; Schiro, Jessica; Houzé de l'Aulnoit, Denis; Beuscart, Régis

    2018-03-23

    The fetal heart rate (FHR) is a marker of fetal well-being in utero (when monitoring maternal and/or fetal pathologies) and during labor. Here, we developed a smart mobile data module for the remote acquisition and transmission (via a Wi-Fi or 4G connection) of FHR recordings, together with a web-based viewer for displaying the FHR datasets on a computer, smartphone or tablet. In order to define the features required by users, we modelled the fetal monitoring procedure (in home and hospital settings) via semi-structured interviews with midwives and obstetricians. Using this information, we developed a mobile data transfer module based on a Raspberry Pi. When connected to a standalone fetal monitor, the module acquires the FHR signal and sends it (via a Wi-Fi or a 3G/4G mobile internet connection) to a secure server within our hospital information system. The archived, digitized signal data are linked to the patient's electronic medical records. An HTML5/JavaScript web viewer converts the digitized FHR data into easily readable and interpretable graphs for viewing on a computer (running Windows, Linux or MacOS) or a mobile device (running Android, iOS or Windows Phone OS). The data can be viewed in real time or offline. The application includes tools required for correct interpretation of the data (signal loss calculation, scale adjustment, and precise measurements of the signal's characteristics). We performed a proof-of-concept case study of the transmission, reception and visualization of FHR data for a pregnant woman at 30 weeks of amenorrhea. She was hospitalized in the pregnancy assessment unit and FHR data were acquired three times a day with a Philips Avalon® FM30 fetal monitor. The prototype (Raspberry Pi) was connected to the fetal monitor's RS232 port. The emission and reception of prerecorded signals were tested and the web server correctly received the signals, and the FHR recording was visualized in real time on a computer, a tablet and smartphones

  16. Development of Lower Plenum Molten Pool Module of Severe Accident Analysis Code in Korea

    International Nuclear Information System (INIS)

    Son, Donggun; Kim, Dong-Ha; Park, Rae-Jun; Bae, Jun-Ho; Shim, Suk-Ku; Marigomen, Ralph

    2014-01-01

    To simulate a severe accident progression of nuclear power plant and forecast reactor pressure vessel failure, we develop computational software called COMPASS (COre Meltdown Progression Accident Simulation Software) for whole physical phenomena inside the reactor pressure vessel from a core heat-up to a vessel failure. As a part of COMPASS project, in the first phase of COMPASS development (2011 - 2014), we focused on the molten pool behavior in the lower plenum, heat-up and ablation of reactor vessel wall. Input from the core module of COMPASS is relocated melt composition and mass in time. Molten pool behavior is described based on the lumped parameter model. Heat transfers in between oxidic, metallic molten pools, overlying water, steam and debris bed are considered in the present study. The models and correlations used in this study are appropriately selected by the physical conditions of severe accident progression. Interaction between molten pools and reactor vessel wall is also simulated based on the lumped parameter model. Heat transfers between oxidic pool, thin crust of oxidic pool and reactor vessel wall are considered and we solve simple energy balance equations for the crust thickness of oxidic pool and reactor vessel wall. As a result, we simulate a benchmark calculation for APR1400 nuclear power plant, with assumption of relocated mass from the core is constant in time such that 0.2ton/sec. We discuss about the molten pool behavior and wall ablation, to validate our models and correlations used in the COMPASS. Stand-alone SIMPLE program is developed as the lower plenum molten pool module for the COMPASS in-vessel severe accident analysis code. SIMPLE program formulates the mass and energy balance for water, steam, particulate debris bed, molten corium pools and oxidic crust from the first principle and uses models and correlations as the constitutive relations for the governing equations. Limited steam table and the material properties are provided

  17. The research and development of module 3D designing system for nuclear power project based on the PDMS

    International Nuclear Information System (INIS)

    Lu Qinwu; Li Yi; Wu Xiangyong

    2012-01-01

    In order to meet the demand of implementing Modularization design in CPR1000 nuclear power projects, this study aims to develop, relying on CPR1000 nuclear power project, the self-reliant module 3D design system based on the PDMS. so as to offer a convenient and effective module 3D design tool for the designers. Satisfactory results have been achieved through the test and application of two design projects. The research and application have entered the domestic advanced level. (authors)

  18. CAPACITY BUILDING FOR CLIMATE CHANGE ADAPTATION: MODULES FOR AGRICULTURAL EXTENSION CURRICULUM DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    B.O. Ogunbameru

    2013-02-01

    Full Text Available Basically, climate change refers to any change in climate overtime, generally caused by natural variability and/or human activities. It has great devastating impact, particularly on agriculture and by extrapolation on farmers and the national economy. The frontline agricultural extension workers are expected to be among the principal stakeholders to teach farmers how to cope with climate change. Consequently, there is a need to develop appropriate teaching package for the training of the frontline agricultural extension workers, based on the myriad of adaptation strategies and practices available in the literature. This paper synthesizes the rationale for capacity building in climate change and the adaptation or coping strategies. The modules (train-the-trainer for teaching agricultural extension workers and farmers are documented in the paper.

  19. The Belle II DEPFET pixel vertex detector. Development of a full-scale module prototype

    International Nuclear Information System (INIS)

    Lemarenko, Mikhail

    2013-11-01

    The Belle II experiment, which will start after 2015 at the SuperKEKB accelerator in Japan, will focus on the precision measurement of the CP-violation mechanism and on the search for physics beyond the Standard Model. A new detection system with an excellent spatial resolution and capable of coping with considerably increased background is required. To address this challenge, a pixel detector based on DEPFET technology has been proposed. A new all silicon integrated circuit, called Data Handling Processor (DHP), is implemented in 65 nm CMOS technology. It is designed to steer the detector and preprocess the generated data. The scope of this thesis covers DHP tests and optimization as well the development of its test environment, which is the first Full-Scale Module Prototype of the DEPFET Pixel Vertex detector.

  20. Short communication: Tryptic β-casein hydrolysate modulates enteric nervous system development in primary culture.

    Science.gov (United States)

    Cossais, F; Clawin-Rädecker, I; Lorenzen, P C; Klempt, M

    2017-05-01

    The intestinal tract of the newborn is particularly sensitive to gastrointestinal disorders, such as infantile diarrhea or necrotizing colitis. Perinatal development of the gut also encompasses the maturation of the enteric nervous system (ENS), a main regulator of intestinal motility and barrier functions. It was recently shown that ENS maturation can be enhanced by nutritional factors to improve intestinal maturation. Bioactivity of milk proteins is often latent, requiring the release of bioactive peptides from inactive native proteins. Several casein-derived hydrolysates presenting immunomodulatory properties have been described recently. Furthermore, accumulating data indicate that milk-derived hydrolysate can enhance gut maturation and enrichment of milk formula with such hydrolysates has recently been proposed. However, the capability of milk-derived bioactive hydrolysate to target ENS maturation has not been analyzed so far. We, therefore, investigated the potential of a recently described tryptic β-casein hydrolysate to modulate ENS growth parameters in an in vitro model of rat primary culture of ENS. Rat primary cultures of ENS were incubated with a bioactive tryptic β-casein hydrolysate and compared with untreated controls or to cultures treated with native β-casein or a Prolyve β-casein hydrolysate (Lyven, Colombelles, France). Differentiation of enteric neurons and enteric glial cells, and establishment of enteric neural network were analyzed using immunohistochemistry and quantitative PCR. Effect of tryptic β-casein hydrolysate on bone morphogenetic proteins (BMP)/Smad pathway, an essential regulator of ENS development, was further assessed using quantitative PCR and immunochemistry. Tryptic β-casein hydrolysate stimulated neurite outgrowth and simultaneously modulated the formation of enteric ganglia-like structures, whereas native β-casein or Prolyve β-casein hydrolysate did not. Additionally, treatment with tryptic bioactive

  1. Development of active learning modules in pharmacology for small group teaching.

    Science.gov (United States)

    Tripathi, Raakhi K; Sarkate, Pankaj V; Jalgaonkar, Sharmila V; Rege, Nirmala N

    2015-01-01

    Current teaching in pharmacology in undergraduate medical curriculum in India is primarily drug centered and stresses imparting factual knowledge rather than on pharmacotherapeutic skills. These skills would be better developed through active learning by the students. Hence modules that will encourage active learning were developed and compared with traditional methods within the Seth GS Medical College, Mumbai. After Institutional Review Board approval, 90 second year undergraduate medical students who consented were randomized into six sub-groups, each with 15 students. Pre-test was administered. The three sub-groups were taught a topic using active learning modules (active learning groups), which included problems on case scenarios, critical appraisal of prescriptions and drug identification. The remaining three sub-groups were taught the same topic in a conventional tutorial mode (tutorial learning groups). There was crossover for the second topic. Performance was assessed using post-test. Questionnaires with Likert-scaled items were used to assess feedback on teaching technique, student interaction and group dynamics. The active and tutorial learning groups differed significantly in their post-test scores (11.3 ± 1.9 and 15.9 ± 2.7, respectively, P active learning session as interactive (vs. 37/90 students in tutorial group) and enhanced their understanding vs. 56/90 in tutorial group), aroused intellectual curiosity (47/90 students of active learning group vs. 30/90 in tutorial group) and provoked self-learning (41/90 active learning group vs. 14/90 in tutorial group). Sixty-four students in the active learning group felt that questioning each other helped in understanding the topic, which was the experience of 25/90 students in tutorial group. Nevertheless, students (55/90) preferred tutorial mode of learning to help them score better in their examinations. In this study, students preferred an active learning environment, though to pass examinations, they

  2. Modulation of ovarian steroidogenesis by adiponectin during delayed embryonic development of Cynopterus sphinx.

    Science.gov (United States)

    Anuradha; Krishna, Amitabh

    2014-09-01

    The aim of present study was to evaluate role of adiponectin in ovarian steroidogenesis during delayed embryonic development of Cynopterus sphinx. This study showed significantly low circulating adiponectin level and a decline in expression of adiponectin receptor 1 (AdipoR1) in the ovary during the period of delayed embryonic development as compared with the normal development. The adiponectin treatment in vivo during the period of delayed development caused significantly increased in circulating progesterone and estradiol levels together with increased expression of AdipoR1 in the ovary. The in vitro study confirmed the stimulatory effect of adiponectin on progesterone synthesis. Both in vivo and in vitro studies showed that the effects of adiponectin on ovarian steroidogenesis were mediated through increased expression of luteinizing hormone-receptor, steroidogenic acute regulatory protein and 3β-hydroxyl steroid dehydrogenase enzyme. The adiponectin treatment may also promote progesterone synthesis by modulating ovarian angiogenesis, cell survival and rate of apoptosis. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Development of a user interface style guide for the reactor protection system cabinet operator module

    International Nuclear Information System (INIS)

    Lee, Hyun-Chul; Lee, Dong-Young; Lee, Jung-Woon

    2004-01-01

    The reactor protection system (RPS) plays the roles of generating the reactor trip signal and the engineered safety features (ESF) actuation signal when the monitored plant processes reach the predefined limits. A Korean project group is developing a new digitalized RPS and the Cabinet Operator Module (COM) of the RPS is used for the RPS integrity testing and monitoring by an equipment operator. A flat panel display (FPD) with a touch screen capability is provided as a main user interface for the RPS operation. To support the RPS COM user interface design, actually the FPD screen design, we developed a user interface style guide because the system designer could not properly deal with the many general human factors design guidelines. To develop the user interface style guide, various design guideline gatherings, a walk-though with a video recorder, guideline selection with respect to user interface design elements, determination of the properties of the design elements, discussion with system designers, and a conversion of the properties into the screen design were carried out. This paper describes the process details and the findings in the course of the style guide development. (Author)

  4. Development and experimental study of oil-free capacitor module for plasma focus device

    Science.gov (United States)

    Sharma, Ravindra Kumar; Sharma, Archana

    2017-03-01

    This development is concerned with the compact capacitor module for a plasma focus device. Oil-free, non-standard geometry capacitors are designed and developed for high current delivery in sub-microseconds time. Metalized dielectric film based pulse capacitor becomes progressively less viable at currents above 10 kA. It is due to reliability and energy scaling difficulties, based on effects such as vaporization, high resistivity, and end connection. Bipolar electrolytic capacitors are also not preferred due to their limited life and comparatively low peak current delivery. Bi-axially oriented polypropylene (BOPP) film with extended aluminum foil is a combination to deliver moderately high power. But, electrically weak points, relative permittivity, and the edge gap margins have made its adoption difficult. A concept has been developed in lab for implementing the above combination in a less complex and costly manner. This paper concerns the development and testing process techniques for quite different hollow cylindrical, oil-free capacitors (4 μ F , 10 kV, 20 nH). Shot life of 1000 has been experimentally performed on the test bed at its rated energy density level. The technological methods and engineering techniques are now available and utilized for manufacturing and testing of BOPP film based oil-free capacitors.

  5. Development of a Study Module on and Pedagogical Approaches to Industrial Environmental Engineering and Sustainability in Mozambique

    Science.gov (United States)

    Husgafvel, Roope; Martikka, Mikko; Egas, Andrade; Ribiero, Natasha; Dahl, Olli

    2017-01-01

    Addressing the sustainability challenges in the forest sector in Mozambique requires capacity building for higher education and training of new skilled expert and future decision-makers. Our approach was to develop a study module on and pedagogical approaches to industrial environmental engineering and sustainability. The idea was to develop a…

  6. The stage of soil development modulates rhizosphere effect along a High Arctic desert chronosequence.

    Science.gov (United States)

    Mapelli, Francesca; Marasco, Ramona; Fusi, Marco; Scaglia, Barbara; Tsiamis, George; Rolli, Eleonora; Fodelianakis, Stilianos; Bourtzis, Kostas; Ventura, Stefano; Tambone, Fulvia; Adani, Fabrizio; Borin, Sara; Daffonchio, Daniele

    2018-05-01

    In mature soils, plant species and soil type determine the selection of root microbiota. Which of these two factors drives rhizosphere selection in barren substrates of developing desert soils has, however, not yet been established. Chronosequences of glacier forelands provide ideal natural environments to identify primary rhizosphere selection factors along the changing edaphic conditions of a developing soil. Here, we analyze changes in bacterial diversity in bulk soils and rhizospheres of a pioneer plant across a High Arctic glacier chronosequence. We show that the developmental stage of soil strongly modulates rhizosphere community assembly, even though plant-induced selection buffers the effect of changing edaphic factors. Bulk and rhizosphere soils host distinct bacterial communities that differentially vary along the chronosequence. Cation exchange capacity, exchangeable potassium, and metabolite concentration in the soil account for the rhizosphere bacterial diversity. Although the soil fraction (bulk soil and rhizosphere) explains up to 17.2% of the variation in bacterial microbiota, the soil developmental stage explains up to 47.7% of this variation. In addition, the operational taxonomic unit (OTU) co-occurrence network of the rhizosphere, whose complexity increases along the chronosequence, is loosely structured in barren compared with mature soils, corroborating our hypothesis that soil development tunes the rhizosphere effect.

  7. The stage of soil development modulates rhizosphere effect along a High Arctic desert chronosequence

    KAUST Repository

    Mapelli, Francesca

    2018-01-09

    In mature soils, plant species and soil type determine the selection of root microbiota. Which of these two factors drives rhizosphere selection in barren substrates of developing desert soils has, however, not yet been established. Chronosequences of glacier forelands provide ideal natural environments to identify primary rhizosphere selection factors along the changing edaphic conditions of a developing soil. Here, we analyze changes in bacterial diversity in bulk soils and rhizospheres of a pioneer plant across a High Arctic glacier chronosequence. We show that the developmental stage of soil strongly modulates rhizosphere community assembly, even though plant-induced selection buffers the effect of changing edaphic factors. Bulk and rhizosphere soils host distinct bacterial communities that differentially vary along the chronosequence. Cation exchange capacity, exchangeable potassium, and metabolite concentration in the soil account for the rhizosphere bacterial diversity. Although the soil fraction (bulk soil and rhizosphere) explains up to 17.2% of the variation in bacterial microbiota, the soil developmental stage explains up to 47.7% of this variation. In addition, the operational taxonomic unit (OTU) co-occurrence network of the rhizosphere, whose complexity increases along the chronosequence, is loosely structured in barren compared with mature soils, corroborating our hypothesis that soil development tunes the rhizosphere effect.

  8. Development of a wearable system module for monitoring physical and mental workload.

    Science.gov (United States)

    Kim, Sinbae; Nakamura, Hiromi; Yoshida, Toshihiko; Kishimoto, Masamichi; Imai, Yohsuke; Matsuki, Noriaki; Ishikawa, Takuji; Yamaguchi, Takami

    2008-11-01

    The population of most developed countries is rapidly aging, which has created a growing demand for home care. A key issue in medicine is supporting the increasing number of elderly patients, both physically and mentally. In this study, we developed a wearable computer that contained modules for measuring electrocardiograms (ECGs) and femoral artery pulse waves using an accelerometer. This system has several benefits: (a) it can provide a database server in each patient's home; (b) its high extendibility and flexibility facilitate adaptation to a patient's needs; and (c) it allows patients to keep their own data, thus protecting the privacy of personal information. To clarify the capabilities and reliability of the system, we applied it to 8 healthy young volunteers during states of physical and mental work. This system successfully detected clear ECGs and femoral artery pulse waves to calculate important bioinformation, including heart rate, pulse wave velocity, and the power spectral density of spontaneous beat-to-beat oscillations in the R-R interval. In this study, we proposed the way to provide an assessment of the physical and mental condition of the subject using analysis of the bio-information with respect to the physical and mental workloads. The present study provides useful knowledge for the development of a wearable computer designed to monitor the physical and mental conditions of older persons and patients.

  9. The stage of soil development modulates rhizosphere effect along a High Arctic desert chronosequence

    KAUST Repository

    Mapelli, Francesca; Marasco, Ramona; Fusi, Marco; Scaglia, Barbara; Tsiamis, George; Rolli, Eleonora; Fodelianakis, Stylianos; Bourtzis, Kostas; Ventura, Stefano; Tambone, Fulvia; Adani, Fabrizio; Borin, Sara; Daffonchio, Daniele

    2018-01-01

    In mature soils, plant species and soil type determine the selection of root microbiota. Which of these two factors drives rhizosphere selection in barren substrates of developing desert soils has, however, not yet been established. Chronosequences of glacier forelands provide ideal natural environments to identify primary rhizosphere selection factors along the changing edaphic conditions of a developing soil. Here, we analyze changes in bacterial diversity in bulk soils and rhizospheres of a pioneer plant across a High Arctic glacier chronosequence. We show that the developmental stage of soil strongly modulates rhizosphere community assembly, even though plant-induced selection buffers the effect of changing edaphic factors. Bulk and rhizosphere soils host distinct bacterial communities that differentially vary along the chronosequence. Cation exchange capacity, exchangeable potassium, and metabolite concentration in the soil account for the rhizosphere bacterial diversity. Although the soil fraction (bulk soil and rhizosphere) explains up to 17.2% of the variation in bacterial microbiota, the soil developmental stage explains up to 47.7% of this variation. In addition, the operational taxonomic unit (OTU) co-occurrence network of the rhizosphere, whose complexity increases along the chronosequence, is loosely structured in barren compared with mature soils, corroborating our hypothesis that soil development tunes the rhizosphere effect.

  10. Development of high sensitivity transimpedance amplifier module for self powered neutron detectors

    International Nuclear Information System (INIS)

    Khan, T.K.; Tamboli, P.K.; Antony, J.; Balasubramanian, R.; Agilandaeswari, K.; Pramanik, M.

    2010-01-01

    This paper describes design and development of a Transimpedance Amplifier for amplification of very low current from in core Self Powered Neutron Detectors (SPND). Measurement of neutron flux is very important for operation, control and protection of Nuclear Power Plant (NPP). SPND is used to measure Reactor incore flux/power. Based on sensitivity of emitter material used in SPND, pitch length and neutron flux (power level); the current output from SPND varies from few pA to few μA. The described amplifier is suitable to use for this current range. The amplifier provides a very high gain using a resistive T network feedback topology. The amplifier is designed in two stages using ultra low bias current FET OPAMPs. Design of Transimpedance amplifier is carefully done to include ultra low input bias current, low offset voltage and noise. The amplifier has in built test facility for calibration and on line test facility for measurement of insulation resistance (IR). The amplifier module has on board isolated DC-DC converter circuit complying MIL/STD/461C/D which generate isolated +/-15V and +12V supply to provide parameter to parameter ground isolation and independence among each module/signal.The output from the amplifier is 0V to 6V for 0 to 150%FP. The design is simulated in computer and amplifier used at TAPS-3 was modified as per new design and has been tested at TAPS-3 site. The amplifier performed satisfactorily. The results showed that the IR measurement technique adopted in the design can tolerate lower IR of SPND in existing design. (author)

  11. Developing, Implementing, and Evaluating the Educational Module Students Active Learning via Internet Observations (SALIO) in Undergraduate Nursing Education.

    Science.gov (United States)

    Salzmann-Erikson, Martin; Bjuhr, Marie; Mårtensson, Gunilla

    2017-04-01

    This study aimed not only to describe the development and implementation of the module but also to evaluate the nursing students' perceptions. A cross-sectional design including 101 students who were asked to participate and answer a survey. We describe the development of the pedagogic module Students Active Learning via Internet Observations based on situated learning. The findings show that learning about service users' own lived experiences via web-based platforms was instructive according to the students: 81% agreed to a high or very high degree. Another important finding was that 96% of students responded that the module had clinical relevance for nursing work. We argue that learning that engages students with data that are contextually and culturally situated is important for developing competence in caregiving. © 2015 Wiley Periodicals, Inc.

  12. How musical training affects cognitive development: rhythm, reward and other modulating variables.

    Science.gov (United States)

    Miendlarzewska, Ewa A; Trost, Wiebke J

    2013-01-01

    Musical training has recently gained additional interest in education as increasing neuroscientific research demonstrates its positive effects on brain development. Neuroimaging revealed plastic changes in the brains of adult musicians but it is still unclear to what extent they are the product of intensive music training rather than of other factors, such as preexisting biological markers of musicality. In this review, we synthesize a large body of studies demonstrating that benefits of musical training extend beyond the skills it directly aims to train and last well into adulthood. For example, children who undergo musical training have better verbal memory, second language pronunciation accuracy, reading ability and executive functions. Learning to play an instrument as a child may even predict academic performance and IQ in young adulthood. The degree of observed structural and functional adaptation in the brain correlates with intensity and duration of practice. Importantly, the effects on cognitive development depend on the timing of musical initiation due to sensitive periods during development, as well as on several other modulating variables. Notably, we point to motivation, reward and social context of musical education, which are important yet neglected factors affecting the long-term benefits of musical training. Further, we introduce the notion of rhythmic entrainment and suggest that it may represent a mechanism supporting learning and development of executive functions. It also hones temporal processing and orienting of attention in time that may underlie enhancements observed in reading and verbal memory. We conclude that musical training uniquely engenders near and far transfer effects, preparing a foundation for a range of skills, and thus fostering cognitive development.

  13. How musical training affects cognitive development: rhythm, reward and other modulating variables.

    Directory of Open Access Journals (Sweden)

    Ewa Aurelia Miendlarzewska

    2014-01-01

    Full Text Available Musical training has recently gained additional interest in education as increasing neuroscientific research demonstrates its positive effects on brain development. Neuroimaging revealed plastic changes in the brains of adult musicians but it is still unclear to what extent they are the product of intensive music training rather than of other factors, such as preexisting biological markers of musicality. In this review, we synthesize a large body of studies demonstrating that benefits of musical training extend beyond the skills it directly aims to train and last well into adulthood. For example, children who undergo musical training have better verbal memory, second language pronunciation accuracy, reading ability and executive functions. Learning to play an instrument as a child may even predict academic performance and IQ in young adulthood. The degree of observed structural and functional adaptation in the brain correlates with intensity and duration of practice. Importantly, the effects on cognitive development depend on the timing of musical initiation due to sensitive periods during development, as well as on several other modulating variables. Notably, we point to motivation, reward and social context of musical education, which are important yet neglected factors affecting the long-term benefits of musical training. Further, we introduce the notion of rhythmic entrainment and suggest that it may represent a mechanism supporting learning and development of executive functions. It also hones temporal processing and orienting of attention in time that may underlie enhancements observed in reading and verbal memory. We conclude that musical training uniquely engenders near and far transfer effects, preparing a foundation for a range of skills, and thus fostering cognitive development.

  14. Development of Power Supply Management Module for Radio Signal Repeaters of Automatic Metering Reading System in Variable Solar Density Conditions

    Directory of Open Access Journals (Sweden)

    Kondratjevs K.

    2016-02-01

    Full Text Available In recent years, there has been significant research focus that revolves around harvesting and minimising energy consumption by wireless sensor network nodes. When a sensor node is depleted of energy, it becomes unresponsive and disconnected from the network that can significantly influence the performance of the whole network. The purpose of the present research is to create a power supply management module in order to provide stable operating voltage for autonomous operations of radio signal repeaters, sensors or gateways of WSN. The developed management module is composed of a solar panel, lithium battery and power supply management module. The novelty of the research is the management module, which ensures stable and uninterrupted operations of electronic equipment in various power supply modes in different situations, simultaneously ensuring energy protection and sustainability of the module components. The management module is able to provide power supply of 5 V for electronics scheme independently, without power interruption switching between power sources and power flows in different directions.

  15. Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes.

    Science.gov (United States)

    Roques, Magali; Wall, Richard J; Douglass, Alexander P; Ramaprasad, Abhinay; Ferguson, David J P; Kaindama, Mbinda L; Brusini, Lorenzo; Joshi, Nimitray; Rchiad, Zineb; Brady, Declan; Guttery, David S; Wheatley, Sally P; Yamano, Hiroyuki; Holder, Anthony A; Pain, Arnab; Wickstead, Bill; Tewari, Rita

    2015-11-01

    Cell-cycle progression and cell division in eukaryotes are governed in part by the cyclin family and their regulation of cyclin-dependent kinases (CDKs). Cyclins are very well characterised in model systems such as yeast and human cells, but surprisingly little is known about their number and role in Plasmodium, the unicellular protozoan parasite that causes malaria. Malaria parasite cell division and proliferation differs from that of many eukaryotes. During its life cycle it undergoes two types of mitosis: endomitosis in asexual stages and an extremely rapid mitotic process during male gametogenesis. Both schizogony (producing merozoites) in host liver and red blood cells, and sporogony (producing sporozoites) in the mosquito vector, are endomitotic with repeated nuclear replication, without chromosome condensation, before cell division. The role of specific cyclins during Plasmodium cell proliferation was unknown. We show here that the Plasmodium genome contains only three cyclin genes, representing an unusual repertoire of cyclin classes. Expression and reverse genetic analyses of the single Plant (P)-type cyclin, CYC3, in the rodent malaria parasite, Plasmodium berghei, revealed a cytoplasmic and nuclear location of the GFP-tagged protein throughout the lifecycle. Deletion of cyc3 resulted in defects in size, number and growth of oocysts, with abnormalities in budding and sporozoite formation. Furthermore, global transcript analysis of the cyc3-deleted and wild type parasites at gametocyte and ookinete stages identified differentially expressed genes required for signalling, invasion and oocyst development. Collectively these data suggest that cyc3 modulates oocyst endomitotic development in Plasmodium berghei.

  16. Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes

    KAUST Repository

    Roques, Magali; Wall, Richard J.; Douglass, Alexander P.; Ramaprasad, Abhinay; Ferguson, David J. P.; Kaindama, Mbinda L.; Brusini, Lorenzo; Joshi, Nimitray; Rchiad, ‍ Zineb; Brady, Declan; Guttery, David S.; Wheatley, Sally P.; Yamano, Hiroyuki; Holder, Anthony A.; Pain, Arnab; Wickstead, Bill; Tewari, Rita

    2015-01-01

    Cell-cycle progression and cell division in eukaryotes are governed in part by the cyclin family and their regulation of cyclin-dependent kinases (CDKs). Cyclins are very well characterised in model systems such as yeast and human cells, but surprisingly little is known about their number and role in Plasmodium, the unicellular protozoan parasite that causes malaria. Malaria parasite cell division and proliferation differs from that of many eukaryotes. During its life cycle it undergoes two types of mitosis: endomitosis in asexual stages and an extremely rapid mitotic process during male gametogenesis. Both schizogony (producing merozoites) in host liver and red blood cells, and sporogony (producing sporozoites) in the mosquito vector, are endomitotic with repeated nuclear replication, without chromosome condensation, before cell division. The role of specific cyclins during Plasmodium cell proliferation was unknown. We show here that the Plasmodium genome contains only three cyclin genes, representing an unusual repertoire of cyclin classes. Expression and reverse genetic analyses of the single Plant (P)-type cyclin, CYC3, in the rodent malaria parasite, Plasmodium berghei, revealed a cytoplasmic and nuclear location of the GFP-tagged protein throughout the lifecycle. Deletion of cyc3 resulted in defects in size, number and growth of oocysts, with abnormalities in budding and sporozoite formation. Furthermore, global transcript analysis of the cyc3-deleted and wild type parasites at gametocyte and ookinete stages identified differentially expressed genes required for signalling, invasion and oocyst development. Collectively these data suggest that cyc3 modulates oocyst endomitotic development in Plasmodium berghei.

  17. Gαq Regulates the Development of Rheumatoid Arthritis by Modulating Th1 Differentiation.

    Science.gov (United States)

    Wang, Dashan; Liu, Yuan; Li, Yan; He, Yan; Zhang, Jiyun; Shi, Guixiu

    2017-01-01

    The G α q-containing G protein, an important member of G q/11 class, is ubiquitously expressed in mammalian cells. G α q has been found to play an important role in immune regulation and development of autoimmune disease such as rheumatoid arthritis (RA). However, how G α q participates in the pathogenesis of RA is still not fully understood. In the present study, we aimed to find out whether G α q controls RA via regulation of Th1 differentiation. We observed that the expression of G α q was negatively correlated with the expression of signature Th1 cytokine (IFN- γ ) in RA patients, which suggests a negative role of G α q in differentiation of Th1 cells. By using G α q knockout ( Gnaq-/- ) mice, we demonstrated that loss of G α q led to enhanced Th1 cell differentiation. G α q negative regulated the differentiation of Th1 cell by modulating the expression of T-bet and the activity of STAT4. Furthermore, we detected the increased ratio of Th1 cells in Gnaq-/- bone marrow (BM) chimeras spontaneously developing inflammatory arthritis. In conclusion, results presented in the study demonstrate that loss of G α q promotes the differentiation of Th1 cells and contributes to the pathogenesis of RA.

  18. Social provocation modulates decision making and feedback processing: Examining the trajectory of development in adolescent participants

    Directory of Open Access Journals (Sweden)

    Hannah L. Pincham

    2015-10-01

    Full Text Available Increasingly, research is turning to the ways in which social context impacts decision making and feedback processing in adolescents. The current study recorded electroencephalography to examine the trajectory of development across adolescence, with a focus on how social context impacts cognition and behaviour. To that end, younger (10–12 years and older (14–16 years adolescents played a modified Taylor Aggression Paradigm against two virtual opponents: a low-provoker and a high-provoker. During the task's decision phase (where participants select punishment for their opponent, we examined two event-related potentials: the N2 and the late positive potential (LPP. During the outcome phase (where participants experience win or loss feedback, we measured the feedback related negativity (FRN. Although N2 amplitudes did not vary with provocation, LPP amplitudes were enhanced under high provocation for the younger group, suggesting that emotional reactivity during the decision phase was heightened for early adolescents. During the outcome phase, the FRN was reduced following win outcomes under high provocation for both groups, suggesting that a highly provocative social opponent may influence the reward response. Collectively, the data argue that social context is an important factor modulating neural responses in adolescent behavioural and brain development.

  19. Tidal modulated flow and sediment flux through Wax Lake Delta distributary channels: Implications for delta development

    Directory of Open Access Journals (Sweden)

    K. Hanegan

    2015-03-01

    Full Text Available In this study, a Delft3D model of the Wax Lake Delta was developed to simulate flow and sediment flux through delta distributary channels. The model was calibrated for tidal constituents as well as velocity and sediment concentration across channel transects. The calibrated model was then used to simulate full spring–neap tidal cycles under constant low flow upstream boundary conditions, with grain size variation in suspended load represented using two sediment fractions. Flow and sediment flux results through distributary channel cross-sections were examined for spatial and temporal variability with the goal of characterizing the role of tides in sediment reworking and delta development. The Wax Lake Delta has prograded through channel extension, river mouth bar deposition, and channel bifurcation. Here we show that tidal modulation of currents influences suspended sand transport, and spatial acceleration through distributary channels at low tides is sufficient to suspend sand in distal reaches during lower flows. The basinward-increasing transport capacity in distributary channels indicates that erosive channel extension could be an important process, even during non-flood events.

  20. Prenatal and adolescent exposure to tobacco smoke modulates the development of white matter microstructure.

    Science.gov (United States)

    Jacobsen, Leslie K; Picciotto, Marina R; Heath, Christopher J; Frost, Stephen J; Tsou, Kristen A; Dwan, Rita A; Jackowski, Marcel P; Constable, Robert T; Mencl, W Einar

    2007-12-05

    Prenatal exposure to maternal smoking has been linked to cognitive and auditory processing deficits in offspring. Preclinical studies have demonstrated that exposure to nicotine disrupts neurodevelopment during gestation and adolescence, possibly by disrupting the trophic effects of acetylcholine. Given recent clinical and preclinical work suggesting that neurocircuits that support auditory processing may be particularly vulnerable to developmental disruption by nicotine, we examined white matter microstructure in 67 adolescent smokers and nonsmokers with and without prenatal exposure to maternal smoking. The groups did not differ in age, educational attainment, IQ, years of parent education, or symptoms of inattention. Diffusion tensor anisotropy and anatomical magnetic resonance images were acquired, and auditory attention was assessed, in all subjects. Both prenatal exposure and adolescent exposure to tobacco smoke was associated with increased fractional anisotropy (FA) in anterior cortical white matter. Adolescent smoking was also associated with increased FA of regions of the internal capsule that contain auditory thalamocortical and corticofugal fibers. FA of the posterior limb of the left internal capsule was positively correlated with reaction time during performance of an auditory attention task in smokers but not in nonsmokers. Development of anterior cortical and internal capsule fibers may be particularly vulnerable to disruption in cholinergic signaling induced by nicotine in tobacco smoke. Nicotine-induced disruption of the development of auditory corticofugal fibers may interfere with the ability of these fibers to modulate ascending auditory signals, leading to greater noise and reduced efficiency of neurocircuitry that supports auditory processing.

  1. Development and validation of a BEAMnrc component module for a miniature multileaf collimator

    Science.gov (United States)

    Doerner, E.; Hartmann, G. H.

    2012-05-01

    A new component module (CM) named mini multileaf collimator (mMLC) was developed for the Monte Carlo code BEAMnrc. It models the geometry of the add-on miniature multileaf collimator ModuLeaf (MRC Systems GmbH, Heidelberg, Germany, now part of Siemens, Erlangen, Germany). The new CM is partly based on the existing CM called DYNVMLC. The development was performed using a modified EGSnrc platform which enables us to work in the Microsoft Visual Studio environment. In order to validate the new CM, the PRIMUS linac with 6 MV x-rays (Siemens OCS, Concord, CA, USA) equipped with the ModuLeaf mMLC was modelled. Validation was performed by two methods: (a) a ray-tracing method to check the correct geometry of the multileaf collimator (MLC) and (b) a comparison of calculated and measured results of the following dosimetrical parameters: output factors, dose profiles, field edge position penumbra, MLC interleaf leakage and transmission values. Excellent agreement was found for all parameters. It was, in particular, found that the relationship between leaf position and field edge depending on the shape of the leaf ends can be investigated with a higher accuracy by this new CM than by measurements demonstrating the usefulness of the new CM.

  2. Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes

    KAUST Repository

    Roques, Magali

    2015-11-13

    Cell-cycle progression and cell division in eukaryotes are governed in part by the cyclin family and their regulation of cyclin-dependent kinases (CDKs). Cyclins are very well characterised in model systems such as yeast and human cells, but surprisingly little is known about their number and role in Plasmodium, the unicellular protozoan parasite that causes malaria. Malaria parasite cell division and proliferation differs from that of many eukaryotes. During its life cycle it undergoes two types of mitosis: endomitosis in asexual stages and an extremely rapid mitotic process during male gametogenesis. Both schizogony (producing merozoites) in host liver and red blood cells, and sporogony (producing sporozoites) in the mosquito vector, are endomitotic with repeated nuclear replication, without chromosome condensation, before cell division. The role of specific cyclins during Plasmodium cell proliferation was unknown. We show here that the Plasmodium genome contains only three cyclin genes, representing an unusual repertoire of cyclin classes. Expression and reverse genetic analyses of the single Plant (P)-type cyclin, CYC3, in the rodent malaria parasite, Plasmodium berghei, revealed a cytoplasmic and nuclear location of the GFP-tagged protein throughout the lifecycle. Deletion of cyc3 resulted in defects in size, number and growth of oocysts, with abnormalities in budding and sporozoite formation. Furthermore, global transcript analysis of the cyc3-deleted and wild type parasites at gametocyte and ookinete stages identified differentially expressed genes required for signalling, invasion and oocyst development. Collectively these data suggest that cyc3 modulates oocyst endomitotic development in Plasmodium berghei.

  3. Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development.

    Science.gov (United States)

    Tomàs, Josep; Garcia, Neus; Lanuza, Maria A; Santafé, Manel M; Tomàs, Marta; Nadal, Laura; Hurtado, Erica; Simó, Anna; Cilleros, Víctor

    2017-01-01

    During the histogenesis of the nervous system a lush production of neurons, which establish an excessive number of synapses, is followed by a drop in both neurons and synaptic contacts as maturation proceeds. Hebbian competition between axons with different activities leads to the loss of roughly half of the neurons initially produced so connectivity is refined and specificity gained. The skeletal muscle fibers in the newborn neuromuscular junction (NMJ) are polyinnervated but by the end of the competition, 2 weeks later, the NMJ are innervated by only one axon. This peripheral synapse has long been used as a convenient model for synapse development. In the last few years, we have studied transmitter release and the local involvement of the presynaptic muscarinic acetylcholine autoreceptors (mAChR), adenosine autoreceptors (AR) and trophic factor receptors (TFR, for neurotrophins and trophic cytokines) during the development of NMJ and in the adult. This review article brings together previously published data and proposes a molecular background for developmental axonal competition and loss. At the end of the first week postnatal, these receptors modulate transmitter release in the various nerve terminals on polyinnervated NMJ and contribute to axonal competition and synapse elimination.

  4. Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development

    Directory of Open Access Journals (Sweden)

    Josep Tomàs

    2017-05-01

    Full Text Available During the histogenesis of the nervous system a lush production of neurons, which establish an excessive number of synapses, is followed by a drop in both neurons and synaptic contacts as maturation proceeds. Hebbian competition between axons with different activities leads to the loss of roughly half of the neurons initially produced so connectivity is refined and specificity gained. The skeletal muscle fibers in the newborn neuromuscular junction (NMJ are polyinnervated but by the end of the competition, 2 weeks later, the NMJ are innervated by only one axon. This peripheral synapse has long been used as a convenient model for synapse development. In the last few years, we have studied transmitter release and the local involvement of the presynaptic muscarinic acetylcholine autoreceptors (mAChR, adenosine autoreceptors (AR and trophic factor receptors (TFR, for neurotrophins and trophic cytokines during the development of NMJ and in the adult. This review article brings together previously published data and proposes a molecular background for developmental axonal competition and loss. At the end of the first week postnatal, these receptors modulate transmitter release in the various nerve terminals on polyinnervated NMJ and contribute to axonal competition and synapse elimination.

  5. Development and validation of the fast doppler broadening module coupled within RMC code

    International Nuclear Information System (INIS)

    Yu Jiankai; Liang Jin'gang; Yu Ganglin; Wang Kan

    2015-01-01

    It is one of the efficient approach to reduce the memory consumption in Monte Carlo based reactor physical simulations by using the On-the-fly Doppler broadening for temperature dependent nuclear cross sections. RXSP is a nuclear cross sections processing code being developed by REAL team in Department of Engineering Physics in Tsinghua University, which has an excellent performance in Doppler broadening the temperature dependent continuous energy neutron cross sections. To meet the dual requirements of both accuracy and efficiency during the Monte Carlo simulations with many materials and many temperatures in it, this work enables the capability of on-the-fly pre-Doppler broadening cross sections during the neutron transport by coupling the Fast Doppler Broaden module in RXSP code embedded in the RMC code also being developed by REAL team in Tsinghua University. Additionally, the original OpenMP-based parallelism has been successfully converted into the MPI-based framework, being fully compatible with neutron transport in RMC code, which has achieved a vast parallel efficiency improvement. This work also provides a flexible approach to solve Monte Carlo based full core depletion calculation with many temperatures feedback in many isotopes. (author)

  6. Development and validation of a BEAMnrc component module for a miniature multileaf collimator

    International Nuclear Information System (INIS)

    Doerner, E; Hartmann, G H

    2012-01-01

    A new component module (CM) named mini multileaf collimator (mMLC) was developed for the Monte Carlo code BEAMnrc. It models the geometry of the add-on miniature multileaf collimator ModuLeaf (MRC Systems GmbH, Heidelberg, Germany, now part of Siemens, Erlangen, Germany). The new CM is partly based on the existing CM called DYNVMLC. The development was performed using a modified EGSnrc platform which enables us to work in the Microsoft Visual Studio environment. In order to validate the new CM, the PRIMUS linac with 6 MV x-rays (Siemens OCS, Concord, CA, USA) equipped with the ModuLeaf mMLC was modelled. Validation was performed by two methods: (a) a ray-tracing method to check the correct geometry of the multileaf collimator (MLC) and (b) a comparison of calculated and measured results of the following dosimetrical parameters: output factors, dose profiles, field edge position penumbra, MLC interleaf leakage and transmission values. Excellent agreement was found for all parameters. It was, in particular, found that the relationship between leaf position and field edge depending on the shape of the leaf ends can be investigated with a higher accuracy by this new CM than by measurements demonstrating the usefulness of the new CM. (paper)

  7. Dental diagnostic clinical instrument ('Canary') development using photothermal radiometry and modulated luminescence

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, R J; Sivagurunathan, K; Garcia, J; Matvienko, A; Mandelis, A [Center for Advanced Diffusion Wave Technologies (CADIFT), Department of Mechanical and Industrial Engineering, University of Toronto, 5 King' s College Road, Toronto, Ontario, M5S 3G8 (Canada); Abrams, S, E-mail: mandelis@mie.utoronto.c [Quantum Dental Technologies, 748 Briar Hill Avenue, Toronto, Ontario, M6B 1L3 (Canada)

    2010-03-01

    Since 1999, our group at the CADIFT, University of Toronto, has developed the application of Frequency Domain Photothermal Radiometry (PTR) and Luminescence (LUM) to dental caries detection. Various cases including artificial caries detection have been studied and some of the inherent advantages of the adaptation of this technique to dental diagnostics in conjunction with modulated luminescence as a dual-probe technique have been reported. Based on these studies, a portable, compact diagnostic instrument for dental clinic use has been designed, assembled and tested. A semiconductor laser, optical fibers, a thermoelectric cooled mid-IR detector, and a USB connected data acquisition card were used. Software lock-in amplifier techniques were developed to compute amplitude and phase of PTR and LUM signals. In order to achieve fast measurement and acceptable signal-to-noise ratio (SNR) for clinical application, swept sine waveforms were used. As a result sampling and stabilization time for each measurement point was reduced to a few seconds. A sophisticated software interface was designed to simultaneously record intra-oral camera images with PTR and LUM responses. Preliminary results using this instrument during clinical trials in a dental clinic showed this instrument could detect early caries both from PTR and LUM signals.

  8. Dental diagnostic clinical instrument (Canary) development using photothermal radiometry and modulated luminescence

    International Nuclear Information System (INIS)

    Jeon, R J; Sivagurunathan, K; Garcia, J; Matvienko, A; Mandelis, A; Abrams, S

    2010-01-01

    Since 1999, our group at the CADIFT, University of Toronto, has developed the application of Frequency Domain Photothermal Radiometry (PTR) and Luminescence (LUM) to dental caries detection. Various cases including artificial caries detection have been studied and some of the inherent advantages of the adaptation of this technique to dental diagnostics in conjunction with modulated luminescence as a dual-probe technique have been reported. Based on these studies, a portable, compact diagnostic instrument for dental clinic use has been designed, assembled and tested. A semiconductor laser, optical fibers, a thermoelectric cooled mid-IR detector, and a USB connected data acquisition card were used. Software lock-in amplifier techniques were developed to compute amplitude and phase of PTR and LUM signals. In order to achieve fast measurement and acceptable signal-to-noise ratio (SNR) for clinical application, swept sine waveforms were used. As a result sampling and stabilization time for each measurement point was reduced to a few seconds. A sophisticated software interface was designed to simultaneously record intra-oral camera images with PTR and LUM responses. Preliminary results using this instrument during clinical trials in a dental clinic showed this instrument could detect early caries both from PTR and LUM signals.

  9. Development of Prototype Outcomes-Based Training Modules for Aesthetic Dentistry

    Science.gov (United States)

    Andres, Maricar Joy T.; Borabo, Milagros L.

    2015-01-01

    The objective of the study is to know the essential components of Aesthetic Dentistry that will be a basis for prototype Outcomes-based training modules. Using a 5-point Likert scale, the researcher-made questionnaire assessed the different elements of Aesthetic Dentistry which are needed in the designing of the training module, the manner of…

  10. Development of mechanical analysis module for simulation of SFR fuel rod behavior using finite element method

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Andong; Jeong, Hyedong; Suh, Namduk [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of); Kim, Hyochan; Yang, Yongsik [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    if the characteristics of 'analytical model' are simple and fast running time, there are some limitations which can disturb the detailed modeling of nature. For instance, contact force between cracked slug and cladding shows much larger than non-cracked one due to the high stress concentration at crack tip. The analytical model cannot simulate the cracked slug model. To resolve the limitations, the finite element method (FEM) has been introduced to simulate the mechanical behavior of fuel rod. The ALFUS code adopts FEM modeling to solve mechanical behavior of fuel rod. In this work, 2D FEM model, so called 'NUFORM2D', has been developed to simulate mechanical behavior of fuel and cladding in SFR. The model will be integrated into audit code system. To evaluate the developed model, a code-to-code benchmark was performed using the commercial FE package (ANSYS). The project for the new fuel performance code development has been launched to evaluate the integrity and safety of SFR fuel in regulation aspects. Based on survey of the previous SFR fuel code system, the mechanical analysis module of the previous code should be improved to resolve limitations. This work develops the advanced mechanical analysis model of SFR fuel rod using finite element method, which is well matured in the mechanical field. The module has been implemented by FORTRAN77 to be called by main program.

  11. Development of mechanical analysis module for simulation of SFR fuel rod behavior using finite element method

    International Nuclear Information System (INIS)

    Shin, Andong; Jeong, Hyedong; Suh, Namduk; Kim, Hyochan; Yang, Yongsik

    2014-01-01

    if the characteristics of 'analytical model' are simple and fast running time, there are some limitations which can disturb the detailed modeling of nature. For instance, contact force between cracked slug and cladding shows much larger than non-cracked one due to the high stress concentration at crack tip. The analytical model cannot simulate the cracked slug model. To resolve the limitations, the finite element method (FEM) has been introduced to simulate the mechanical behavior of fuel rod. The ALFUS code adopts FEM modeling to solve mechanical behavior of fuel rod. In this work, 2D FEM model, so called 'NUFORM2D', has been developed to simulate mechanical behavior of fuel and cladding in SFR. The model will be integrated into audit code system. To evaluate the developed model, a code-to-code benchmark was performed using the commercial FE package (ANSYS). The project for the new fuel performance code development has been launched to evaluate the integrity and safety of SFR fuel in regulation aspects. Based on survey of the previous SFR fuel code system, the mechanical analysis module of the previous code should be improved to resolve limitations. This work develops the advanced mechanical analysis model of SFR fuel rod using finite element method, which is well matured in the mechanical field. The module has been implemented by FORTRAN77 to be called by main program

  12. Development of high-efficiency solar cells and modules. Optimised production processes and more durable modules can reduce the costs for producing solar power by a third; Hocheffiziente Solarzellen und Module entwickeln. Optimierte Fertigungsablaeufe und langlebigere Module koennen die Erzeugung von Solarstrom um ein Drittel billiger machen

    Energy Technology Data Exchange (ETDEWEB)

    Hirn, Gerhard

    2013-09-01

    Research institutes, photovoltaic producers, system manufacturers and solar industry suppliers are working together to produce more powerful and durable modules in a more efficient manner. In the SONNE project, companies and researchers are optimising the output and production of modules made of crystalline silicon cells, whereby they are covering the entire production chain and are making the new developments ready for production in a short time. With their developments they want to reduce the costs of solar power by a third.

  13. Development of a CMOS time memory cell VLSI and CAMAC module with 0.5 ns resolution

    International Nuclear Information System (INIS)

    Arai, Y.; Ikeno, M.; Matsumura, T.

    1992-01-01

    A CMOS time-to-digital converter chip, the Time Memory Cell (TMC), for high-rate wire chamber application has been developed. The chip has a timing resolution of 0.52 ns, dissipates only 7 mW/channel, and contains 4 channels in a chip. Each channel has 1024 memory locations which act as a buffer 1μs deep. The chip was fabricated in a 0.8 μm CMOS process and is 5.0 mm by 5.6 mm. Using the TMC chip, a CAMAC module with 32 input channels was developed. This module is designed to operate in both 'Common Start' and 'Common Stop' modes. The circuit of the module and test results are described in this paper

  14. Engineering study, development and prototype fabrication of the supporting system for the CLIC Two-Beam Module

    CERN Document Server

    AUTHOR|(CDS)2068725; Karyotakis, Yannis; Dahoo, Pierre Richard; Alexopoulos, Theo; MEIS, Costantin; De Conto, Jean Marie; Jeremie, Andrea; Puzot, Patrique

    CERN, the European Organization for Nuclear Research, is based on the international collaboration in the field of high-energy particle physics research. The experiments carried out in its facilities are achieved through the existing particle accelerators. In addition, advanced accelerator research and development is one of the goals of CERN. For this reason, CLIC (the Compact LInear Collider) a new electron-positron linear accelerator is being studied at CERN. CLIC is built by the assembly of the Two-Beam Modules and takes advantage of an innovative acceleration principle, the Two-Beam acceleration. Each Module contains several technical systems that contribute to its successful operation. This thesis presents the development of the prototype supporting system for the CLIC Two-Beam Module. At first, the physics requirements are translated into technical specifications and the fundamental parts of the supporting system are defined. The CLIC operational conditions are identified and the corresponding boundaries...

  15. Principles of Practical Training Organization in a Networking (Development of the Module "Psychological Prevention of Behavioral Disorders and Abnormalities in Development" as Example

    Directory of Open Access Journals (Sweden)

    Bogdanovich N. V.

    2016-01-01

    Full Text Available The article presents principles of inserting study subjects and practices in educational modules running with network organizations (internship sites. We proposed a methodological basis of the modular organization of educational process in the framework of the master's program, combied the activity, competence and psychotechnical approaches. Networking of leading chair and specially selected organizations providing the base for practical training solves the problem of organizing activity-related content of educational module. We discussed the main options for networking with the databases of practice and offered methodological principles of designing the educational practice-oriented module, wherein the main principle is the reflexive and activity character of networking. We proposed activity-based content of educational module "Psychological prevention of behavioral disorders and abnormalities in development", based on the substantial psychological definition of psychoprophylaxis as a directions of professional activity of the psychologist.

  16. Development of Instructional Materials for Electrochemical Module Class XII Science High School Students with Guided Inquiry Learning Approach

    Directory of Open Access Journals (Sweden)

    Lilik Fatmawati

    2014-06-01

    Full Text Available Pengembangan Bahan Ajar Modul Elektrokimia untuk Siswa SMA Kelas XII IPA dengan Pendekatan Pembelajaran Inkuiri Terbimbing Abstract: The aim of this study was to determine the feasibility and effectiveness of the electrochemical module for high school students of class XII results of development. Electrochemical module of the development consists of two learning activities, ie to the material Volta cells and electrolysis cells for the material. Results of the assessment by two chemistry lecturer, State University of Malang and two chemistry teachers XII as an expert content / learning material for eligibility contents was 92.9%, for eligibility and completeness of presentation is 91.1%, and for the eligibility of language is 92.3% , which is classified as very feasible criteria. Overall the average value was 92.1 feasibility. Effectiveness module is indicated by the results of the development of perception and student learning outcomes. Students' perceptions obtained from student assessment results to module development. In the limited field trials obtained average value is 81.8 for all aspects of the maximum value of 100. Obtaining the average value of student learning outcomes for the cognitive aspect is 83.3, for the affective aspect is 82.3, and for the psychomotor aspect is 83.8 out of 100. The maximum value of the overall results of the study showed that the electrochemical module for high school students Class XII Science development results are very decent and very effectively used in the learning process. Key Words: guided inquiry, electrochemical module, model 4-D Abstrak: Tujuan penelitian ini adalah mengetahui kelayakan, dan keefektifan modul elektrokimia untuk siswa SMA kelas XII hasil pengembangan. Modul Elektrokimia hasil pengembangan terdiri dari dua kegiatan belajar, yaitu untuk materi sel Volta dan untuk materi sel elektrolisis. Hasil penilaian oleh dua dosen kimia Universitas Negeri Malang dan dua guru kimia kelas XII sebagai

  17. Development of a 33 kV, 20 A long pulse converter modulator for high average power klystron

    Energy Technology Data Exchange (ETDEWEB)

    Reghu, T.; Mandloi, V.; Shrivastava, Purushottam [Pulsed High Power Microwave Section, Raja Ramanna Centre for Advanced Technology, Indore 452013, M.P. (India)

    2014-05-15

    Research, design, and development of high average power, long pulse modulators for the proposed Indian Spallation Neutron Source are underway at Raja Ramanna Centre for Advanced Technology. With this objective, a prototype of long pulse modulator capable of delivering 33 kV, 20 A at 5 Hz repetition rate has been designed and developed. Three Insulated Gate Bipolar Transistors (IGBT) based switching modules driving high frequency, high voltage transformers have been used to generate high voltage output. The IGBT based switching modules are shifted in phase by 120° with respect to each other. The switching frequency is 25 kHz. Pulses of 1.6 ms pulse width, 80 μs rise time, and 70 μs fall time have been achieved at the modulator output. A droop of ±0.6% is achieved using a simple segmented digital droop correction technique. The total fault energy transferred to the load during fault has been measured by conducting wire burn tests and is found to be within 3.5 J.

  18. Development of a 33 kV, 20 A long pulse converter modulator for high average power klystron

    International Nuclear Information System (INIS)

    Reghu, T.; Mandloi, V.; Shrivastava, Purushottam

    2014-01-01

    Research, design, and development of high average power, long pulse modulators for the proposed Indian Spallation Neutron Source are underway at Raja Ramanna Centre for Advanced Technology. With this objective, a prototype of long pulse modulator capable of delivering 33 kV, 20 A at 5 Hz repetition rate has been designed and developed. Three Insulated Gate Bipolar Transistors (IGBT) based switching modules driving high frequency, high voltage transformers have been used to generate high voltage output. The IGBT based switching modules are shifted in phase by 120° with respect to each other. The switching frequency is 25 kHz. Pulses of 1.6 ms pulse width, 80 μs rise time, and 70 μs fall time have been achieved at the modulator output. A droop of ±0.6% is achieved using a simple segmented digital droop correction technique. The total fault energy transferred to the load during fault has been measured by conducting wire burn tests and is found to be within 3.5 J

  19. Development of a 33 kV, 20 A long pulse converter modulator for high average power klystron

    Science.gov (United States)

    Reghu, T.; Mandloi, V.; Shrivastava, Purushottam

    2014-05-01

    Research, design, and development of high average power, long pulse modulators for the proposed Indian Spallation Neutron Source are underway at Raja Ramanna Centre for Advanced Technology. With this objective, a prototype of long pulse modulator capable of delivering 33 kV, 20 A at 5 Hz repetition rate has been designed and developed. Three Insulated Gate Bipolar Transistors (IGBT) based switching modules driving high frequency, high voltage transformers have been used to generate high voltage output. The IGBT based switching modules are shifted in phase by 120° with respect to each other. The switching frequency is 25 kHz. Pulses of 1.6 ms pulse width, 80 μs rise time, and 70 μs fall time have been achieved at the modulator output. A droop of ±0.6% is achieved using a simple segmented digital droop correction technique. The total fault energy transferred to the load during fault has been measured by conducting wire burn tests and is found to be within 3.5 J.

  20. Modulation of GABAergic Transmission in Development and Neurodevelopmental Disorders: Investigating Physiology and Pathology to Gain Therapeutic Perspectives

    Directory of Open Access Journals (Sweden)

    Gabriele eDeidda

    2014-05-01

    Full Text Available During mammalian ontogenesis, the neurotransmitter GABA is a fundamental regulator of neuronal networks. In neuronal development, GABAergic signaling regulates neural proliferation, migration, differentiation, and neuronal-network wiring. In the adult, GABA orchestrates the activity of different neuronal cell-types largely interconnected, by powerfully modulating synaptic activity. GABA exerts these functions by binding to chloride-permeable ionotropic GABAA receptors and metabotropic GABAB receptors. According to its functional importance during development, GABA is implicated in a number of neurodevelopmental disorders such as autism, Fragile X, Rett syndrome, Down syndrome, schizophrenia, Tourette's syndrome and neurofibromatosis.The strength and polarity of GABAergic transmission is continuously modulated during physiological, but also pathological conditions. For GABAergic transmission through GABAA receptors, strength regulation is achieved by different mechanisms such as modulation of GABAA receptors themselves, variation of intracellular chloride concentration, and alteration in GABA metabolism. In the never-ending effort to find possible treatments for GABA-related neurological diseases, of great importance would be modulating GABAergic transmission in a safe and possibly physiological way, without the dangers of either silencing network activity or causing epileptic seizures. In this review, we will discuss the different ways to modulate GABAergic transmission normally at work both during physiological and pathological conditions. Our aim is to highlight new research perspectives for therapeutic treatments that reinstate natural and physiological brain functions in neuro-pathological conditions.

  1. Dioxin modulates expression of receptor for activated C kinase (RACK-1) in developing neurons

    Energy Technology Data Exchange (ETDEWEB)

    Yang, J.H.; Kim, S.Y.; Lee, H.G.; Kim, M.Y.; Lee, J.H.; Chae, W.G. [Catholic Univ. of Daegu, Dept. of Pharmacology/Toxicology, Daegu (Korea)

    2004-09-15

    TCDD is sensitive to the central nerve system of the developing brain. The TCDD-induced neurodevelopmental deficits include the cognitive disability and motor dysfunction. While TCDD may lead to neurodevelopmental and neurobehavioral deficit, it is not known which molecular substances are intracellular targets for TCDD. Since TCDD accumulates in brain and the brain contains the Ah receptor, it is possible that TCDD may act at the target site such as cerebellum, which is responsible for cognitive abilities and motor function. A recent in vitro studies using cerebellar granule cells demonstrated a translocation of PKC-{alpha} and {epsilon} following the TCDD or PCB exposure. One of the most pivotal second messenger molecules involved in neuronal function and development is protein kinase C (PKC). PKC signaling pathways have been implicated as an important factor in learning and memory processes. PKC signaling events are optimized by the adaptor proteins, which organize PKCs near their selective substrates and away from others. RACK-1(receptor for activated C-kinase) is one of adaptor proteins that anchor the activated PKC at the site of translocation 6. RACKs bind PKC only in the presence of PKC activators. RACKs are 30- and 36-kDa proteins located in cytoskeletal compartment and play a key role in PKC activation and in membrane amchoring. Since different PKC isoforms translocate to distinct subcellular sites on activation, it is suggested that isoform-specific RACK may be present. Activation of certain PKC isoforms (PKC-a and {beta}II) is preferentially associated with RACK-1. While TCDD modulates PKC signaling pathway, role of RACK-1 on TCDD-mediated signaling pathway is not known. To identify the intracellular target for TCDD and understand a mechanism of signaling pathway in the developing brain, the present study attempted to analyze effects of RACK-1 in the cerebellar granule cells following TCDD exposure.

  2. Dynamic simulator for nuclear power plants (DSNP): development, verification, and expansion of modules

    International Nuclear Information System (INIS)

    Larson, H.A.; Dean, E.M.; Koenig, J.F.; Gale, J.G.; Lehto, W.K.

    1984-01-01

    The DSNP Simulation Language facilitates whole reactor plant simulation and design. Verification includes DSNP dynamic modeling of Experimental Breeder Reactor No. 2 (EBR-II) plant experiments as well as comparisons with verified simulation programs. Great flexibility is allowed in expanding the DSNP language and accommodate other computer languages. The component modules of DSNP, contained in libraries, are continually updated with new, improved, and verified modules. The modules are used to simulate the dynamic response of LMFBR reactor systems to upset and transient conditions, with special emphasis on investigations of inherent shutdown mechanisms

  3. Development of the VESUVIUS module. Molten jet breakup modeling and model verification

    Energy Technology Data Exchange (ETDEWEB)

    Vierow, K. [Nuclear Power Engineering Corp., Tokyo (Japan); Nagano, Katsuhiro; Araki, Kazuhiro

    1998-01-01

    With the in-vessel vapor explosion issue ({alpha}-mode failure) now considered to pose an acceptably small risk to the safety of a light water reactor, ex-vessel vapor explosions are being given considerable attention. Attempts are being made to analytically model breakup of continuous-phase jets, however uncertainty exists regarding the basic phenomena. In addition, the conditions upon reactor vessel failure, which determine the starting point of the ex-vessel vapor explosion process, are difficult to quantify. Herein, molten jet ejection from the reactor pressure vessel is characterized. Next, the expected mode of jet breakup is determined and the current state of analytical modeling is reviewed. A jet breakup model for ex-vessel scenarios, with the primary breakup mechanism being the Kelvin-Helmholtz instability, is described. The model has been incorporated into the VESUVIUS module and comparisons of VESUVIUS calculations against FARO L-06 experimental data show differences, particularly in the pressure curve and amount of jet breakup. The need for additional development to resolve these differences is discussed. (author)

  4. Development of a quality control system in intensity modulated radiotherapy (IMRT)

    International Nuclear Information System (INIS)

    Souza, Roberto Salomon de; Braz, Delson

    2013-01-01

    The more complex the technique of radiotherapy is, the more refined the quality control must be. The technique of Intensity Modulated Radiotherapy (IMRT) is one of the technological innovations that gained space in the whole worlds in the last decade whose parameters of quality control are not fully established yet. The present work developed a phantom for quality control in IMRT to be implemented in the routine of the Radiotherapy Quality Control Program (PQRT) of the Brazilian National Cancer Institute (INCa). The device consists of a block formed by several polystyrene slice with TDLs and radiochromic film inserted. It should be sent (or taken) to the Program participating institutions to be irradiated under certain conditions and then be returned to the PQRT., where the discrepancy degree between the planned treatment and those effectively delivered will be evaluated. The system was validated through the test cases and the pilot program preformed in nine radiotherapy centers that perform IMRT in the southeast region of Brazil. (author)

  5. Modeling the Exo-Brake and the Development of Strategies for De-Orbit Drag Modulation

    Science.gov (United States)

    Murbach, M. S.; Papadopoulos, P.; Glass, C.; Dwyer-Cianciolo, A.; Powell, R. W.; Dutta, S.; Guarneros-Luna, A.; Tanner, F. A.; Dono, A.

    2016-01-01

    The Exo-Brake is a simple, non-propulsive means of de-orbiting small payloads from orbital platforms such as the International Space Station (ISS). Two de-orbiting experiments with fixed surface area Exo-Brakes have been successfully conducted in the last two years on the TechEdSat-3 and -4 nano-satellite missions. The development of the free molecular flow aerodynamic data-base is presented in terms of angle of attack, projected front surface area variation, and altitude. Altitudes are considered ranging from the 400km ISS jettison altitude to 90km. Trajectory tools are then used to predict de-orbit/entry corridors with the inclusion of the key atmospheric and geomagnetic uncertainties. Control system strategies are discussed which will be applied to the next two planned TechEdSat-5 and -6 nano-satellite missions - thus increasing the targeting accuracy at the Von Karman altitude through the proposed drag modulation technique.

  6. Development of CXCR4 modulators by virtual HTS of a novel amide-sulfamide compound library.

    Science.gov (United States)

    Bai, Renren; Shi, Qi; Liang, Zhongxing; Yoon, Younghyoun; Han, Yiran; Feng, Amber; Liu, Shuangping; Oum, Yoonhyeun; Yun, C Chris; Shim, Hyunsuk

    2017-01-27

    CXCR4 plays a crucial role in recruitment of inflammatory cells to inflammation sites at the beginning of the disease process. Modulating CXCR4 functions presents a new avenue for anti-inflammatory strategies. However, using CXCR4 antagonists for a long term usage presents potential serious side effect due to their stem cell mobilizing property. We have been developing partial CXCR4 antagonists without such property. A new computer-aided drug design program, the FRESH workflow, was used for anti-CXCR4 lead compound discovery and optimization, which coupled both compound library building and CXCR4 docking screens in one campaign. Based on the designed parent framework, 30 prioritized amide-sulfamide structures were obtained after systemic filtering and docking screening. Twelve compounds were prepared from the top-30 list. Most synthesized compounds exhibited good to excellent binding affinity to CXCR4. Compounds Ig and Im demonstrated notable in vivo suppressive activity against xylene-induced mouse ear inflammation (with 56% and 54% inhibition). Western blot analyses revealed that Ig significantly blocked CXCR4/CXCL12-mediated phosphorylation of Akt. Moreover, Ig attenuated the amount of TNF-α secreted by pathogenic E. coli-infected macrophages. More importantly, Ig had no observable cytotoxicity. Our results demonstrated that FRESH virtual high throughput screening program of targeted chemical class could successfully find potent lead compounds, and the amide-sulfamide pharmacophore was a novel and effective framework blocking CXCR4 function. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  7. Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development.

    Science.gov (United States)

    Knopp, Matthias Manne; Löbmann, Korbinian; Elder, David P; Rades, Thomas; Holm, René

    2016-05-25

    Differential scanning calorimetry (DSC) is frequently the thermal analysis technique of choice within preformulation and formulation sciences because of its ability to provide detailed information about both the physical and energetic properties of a substance and/or formulation. However, conventional DSC has shortcomings with respect to weak transitions and overlapping events, which could be solved by the use of the more sophisticated modulated DSC (mDSC). mDSC has multiple potential applications within the pharmaceutical field and the present review provides an up-to-date overview of these applications. It is aimed to serve as a broad introduction to newcomers, and also as a valuable reference for those already practising in the field. Complex mDSC was introduced more than two decades ago and has been an important tool for the quantification of amorphous materials and development of freeze-dried formulations. However, as discussed in the present review, a number of other potential applications could also be relevant for the pharmaceutical scientist. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. DEVELOPMENT OF PRESSURIZED CIRCULATIONG FLUIDIZED BED PARTIAL GASIFICATION MODULE(PGM)

    Energy Technology Data Exchange (ETDEWEB)

    Archie Robertson

    2003-04-17

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building block that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the January 1--March 31, 2003 time period.

  9. Prenatal exposure to residential air pollution and infant mental development: modulation by antioxidants and detoxification factors.

    Science.gov (United States)

    Guxens, Mònica; Aguilera, Inmaculada; Ballester, Ferran; Estarlich, Marisa; Fernández-Somoano, Ana; Lertxundi, Aitana; Lertxundi, Nerea; Mendez, Michelle A; Tardón, Adonina; Vrijheid, Martine; Sunyer, Jordi

    2012-01-01

    Air pollution effects on children's neurodevelopment have recently been suggested to occur most likely through the oxidative stress pathway. We aimed to assess whether prenatal exposure to residential air pollution is associated with impaired infant mental development, and whether antioxidant/detoxification factors modulate this association. In the Spanish INfancia y Medio Ambiente (INMA; Environment and Childhood) Project, 2,644 pregnant women were recruited during their first trimester. Nitrogen dioxide (NO2) and benzene were measured with passive samplers covering the study areas. Land use regression models were developed for each pollutant to predict average outdoor air pollution levels for the entire pregnancy at each residential address. Maternal diet was obtained at first trimester through a validated food frequency questionnaire. Around 14 months, infant mental development was assessed using Bayley Scales of Infant Development. Among the 1,889 children included in the analysis, mean exposure during pregnancy was 29.0 μg/m3 for NO2 and 1.5 μg/m3 for benzene. Exposure to NO2 and benzene showed an inverse association with mental development, although not statistically significant, after adjusting for potential confounders [β (95% confidence interval) = -0.95 (-3.90, 1.89) and -1.57 (-3.69, 0.56), respectively, for a doubling of each compound]. Stronger inverse associations were estimated for both pollutants among infants whose mothers reported low intakes of fruits/vegetables during pregnancy [-4.13 (-7.06, -1.21) and -4.37 (-6.89, -1.86) for NO2 and benzene, respectively], with little evidence of associations in the high-intake group (interaction p-values of 0.073 and 0.047). Inverse associations were also stronger in non-breast-fed infants and infants with low maternal vitamin D, but effect estimates and interactions were not significant. Our findings suggest that prenatal exposure to residential air pollutants may adversely affect infant mental

  10. Development of Health Education Learning Module in Bac.TSE-LDPE Programme in TTI: Needs Analysis Study

    Science.gov (United States)

    Ujang, Alijah; Alias, Norlidah; Siraj, Saedah

    2015-01-01

    This study is to explore the need to develop learning modules of health education for trainee teachers in the Bachelor Of Teaching (Hons)(Special Education-Learning Disabilities For Primary Education) Programme (Bac.TSE-LDPE) in the Teacher Training Institute (TTI). The questionnaire uses the Likert scale with the close ended questions analysed by…

  11. Integrating Anatomy Training into Radiation Oncology Residency: Considerations for Developing a Multidisciplinary, Interactive Learning Module for Adult Learners

    Science.gov (United States)

    Labranche, Leah; Johnson, Marjorie; Palma, David; D'Souza, Leah; Jaswal, Jasbir

    2015-01-01

    Radiation oncologists require an in-depth understanding of anatomical relationships for modern clinical practice, although most do not receive formal anatomy training during residency. To fulfill the need for instruction in relevant anatomy, a series of four multidisciplinary, interactive learning modules were developed for a cohort of radiation…

  12. SU-F-T-184: 3D Range-Modulator for Scanned Particle Therapy: Development, Monte Carlo Simulations and Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Simeonov, Y; Penchev, P; Ringbaek, T Printz [University of Applied Sciences, Institute of Medical Physics and Radiation Protection, Giessen (Germany); Brons, S [Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg (Germany); Weber, U [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany); Zink, K [University of Applied Sciences, Institute of Medical Physics and Radiation Protection, Giessen (Germany); University Hospital Giessen-Marburg, Marburg (Germany)

    2016-06-15

    Purpose: Active raster scanning in particle therapy results in highly conformal dose distributions. Treatment time, however, is relatively high due to the large number of different iso-energy layers used. By using only one energy and the so called 3D range-modulator irradiation times of a few seconds only can be achieved, thus making delivery of homogeneous dose to moving targets (e.g. lung cancer) more reliable. Methods: A 3D range-modulator consisting of many pins with base area of 2.25 mm2 and different lengths was developed and manufactured with rapid prototyping technique. The form of the 3D range-modulator was optimised for a spherical target volume with 5 cm diameter placed at 25 cm in a water phantom. Monte Carlo simulations using the FLUKA package were carried out to evaluate the modulating effect of the 3D range-modulator and simulate the resulting dose distribution. The fine and complicated contour form of the 3D range-modulator was taken into account by a specially programmed user routine. Additionally FLUKA was extended with the capability of intensity modulated scanning. To verify the simulation results dose measurements were carried out at the Heidelberg Ion Therapy Center (HIT) with a 400.41 MeV 12C beam. Results: The high resolution measurements show that the 3D range-modulator is capable of producing homogeneous 3D conformal dose distributions, simultaneously reducing significantly irradiation time. Measured dose is in very good agreement with the previously conducted FLUKA simulations, where slight differences were traced back to minor manufacturing deviations from the perfect optimised form. Conclusion: Combined with the advantages of very short treatment time the 3D range-modulator could be an alternative to treat small to medium sized tumours (e.g. lung metastasis) with the same conformity as full raster-scanning treatment. Further simulations and measurements of more complex cases will be conducted to investigate the full potential of the 3D

  13. Development of efficient air-cooling strategies for lithium-ion battery module based on empirical heat source model

    International Nuclear Information System (INIS)

    Wang, Tao; Tseng, K.J.; Zhao, Jiyun

    2015-01-01

    Thermal modeling is the key issue in thermal management of lithium-ion battery system, and cooling strategies need to be carefully investigated to guarantee the temperature of batteries in operation within a narrow optimal range as well as provide cost effective and energy saving solutions for cooling system. This article reviews and summarizes the past cooling methods especially forced air cooling and introduces an empirical heat source model which can be widely applied in the battery module/pack thermal modeling. In the development of empirical heat source model, three-dimensional computational fluid dynamics (CFD) method is employed, and thermal insulation experiments are conducted to provide the key parameters. A transient thermal model of 5 × 5 battery module with forced air cooling is then developed based on the empirical heat source model. Thermal behaviors of battery module under different air cooling conditions, discharge rates and ambient temperatures are characterized and summarized. Varies cooling strategies are simulated and compared in order to obtain an optimal cooling method. Besides, the battery fault conditions are predicted from transient simulation scenarios. The temperature distributions and variations during discharge process are quantitatively described, and it is found that the upper limit of ambient temperature for forced air cooling is 35 °C, and when ambient temperature is lower than 20 °C, forced air-cooling is not necessary. - Highlights: • An empirical heat source model is developed for battery thermal modeling. • Different air-cooling strategies on module thermal characteristics are investigated. • Impact of different discharge rates on module thermal responses are investigated. • Impact of ambient temperatures on module thermal behaviors are investigated. • Locations of maximum temperatures under different operation conditions are studied.

  14. Development and Applicability Demonstration of a Remote Inspection Module for Inspection of Reactor Internals in an SFR

    International Nuclear Information System (INIS)

    Kim, Hoewoong; Joo, Youngsang; Park, Changgyu; Kim, Jongbum; Bae, Jinho

    2014-01-01

    Since liquid sodium is optically opaque, the ultrasonic inspection technique has been mainly employed for inspection of reactor internals in a Sodium-cooled Fast Reactor (SFR). Until now, two types of ultrasonic sensors have been mainly developed; immersion and waveguide sensors. An immersion sensor can provide a high-resolution image, but it may have problems in terms of reliability and life time because the sensor is exposed to high temperature during inspection. On the other hand, a waveguide sensor can maintain its performance during long-term inspection in high temperature because it installs an ultrasonic transducer in a cold region even though such a high-frequency ultrasonic wave cannot be used owing to the long propagation distance [4-6]. In this work, a remote inspection module employing four 10 m long waveguide sensors was newly developed and several performance tests were carried out in water to demonstrate the applicability of the developed remote inspection module to inspection of reactor internals in an SFR. In this work, a remote inspection module for inspection of reactor internals in an SFR was newly developed. The developed remote inspection module employs four 10 m long waveguide sensors for multiple inspection applications: a horizontal beam waveguide sensor for ranging inspection, two vertical beam waveguide sensors for viewing inspection and a 45 .deg. angle beam waveguide sensor for identification inspection. Several performance tests such as ranging, viewing and identification inspections were carried out for simulated nuclear fuel assembly specimens in water, and the applicability of the developed remote inspection module to inspection of reactor internals in an SFR was demonstrated

  15. Development and Applicability Demonstration of a Remote Inspection Module for Inspection of Reactor Internals in an SFR

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hoewoong; Joo, Youngsang; Park, Changgyu; Kim, Jongbum [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Bae, Jinho [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    Since liquid sodium is optically opaque, the ultrasonic inspection technique has been mainly employed for inspection of reactor internals in a Sodium-cooled Fast Reactor (SFR). Until now, two types of ultrasonic sensors have been mainly developed; immersion and waveguide sensors. An immersion sensor can provide a high-resolution image, but it may have problems in terms of reliability and life time because the sensor is exposed to high temperature during inspection. On the other hand, a waveguide sensor can maintain its performance during long-term inspection in high temperature because it installs an ultrasonic transducer in a cold region even though such a high-frequency ultrasonic wave cannot be used owing to the long propagation distance [4-6]. In this work, a remote inspection module employing four 10 m long waveguide sensors was newly developed and several performance tests were carried out in water to demonstrate the applicability of the developed remote inspection module to inspection of reactor internals in an SFR. In this work, a remote inspection module for inspection of reactor internals in an SFR was newly developed. The developed remote inspection module employs four 10 m long waveguide sensors for multiple inspection applications: a horizontal beam waveguide sensor for ranging inspection, two vertical beam waveguide sensors for viewing inspection and a 45 .deg. angle beam waveguide sensor for identification inspection. Several performance tests such as ranging, viewing and identification inspections were carried out for simulated nuclear fuel assembly specimens in water, and the applicability of the developed remote inspection module to inspection of reactor internals in an SFR was demonstrated.

  16. Development and Psychometric Properties of the Dialysis Module of the WHOQOL-BREF Taiwan Version

    Directory of Open Access Journals (Sweden)

    Shu-Chang Yang

    2006-01-01

    Conclusion: Besides broader coverage than the core WHOQOL-BREF(TW, the dialysis module of the WHOQOL-BREF(TW is a valid, reliable and sensitive QOL instrument for the assessment of HD patients in Taiwan.

  17. Development and testing of shingle-type solar cell modules. Quarterly report No. 2

    Energy Technology Data Exchange (ETDEWEB)

    Shepard, N.F.

    1978-01-05

    The details of a shingle module design which produces in excess of 97 watts/m/sup 2/ of module area at 1 kW/m/sup 2/ insolation and at 60/sup 0/C are reported. This selected design employs a tempered glass coverplate to provide the primary solar cell structural support. The use of the B.F. Goodrich FLEXSEAL roofing system as the outer skin of the shingle substrate provides a high confidence of achieving the 15 year service life goal. The fabrication and testing of a preproduction module of this design has demonstrated that this selected approach will meet the environmental testing requirements imposed by the contract. Attempts to fabricate a preproduction module of an alternative design, which embeds the solar cell assembly within a methyl methacrylate casting, proved unsuccessful.

  18. Gas-grain simulation experiment module conceptual design and gas-grain simulation facility breadboard development

    Science.gov (United States)

    Zamel, James M.; Petach, Michael; Gat, Nahum; Kropp, Jack; Luong, Christina; Wolff, Michael

    1993-12-01

    This report delineates the Option portion of the Phase A Gas-Grain Simulation Facility study. The conceptual design of a Gas-Grain Simulation Experiment Module (GGSEM) for Space Shuttle Middeck is discussed. In addition, a laboratory breadboard was developed during this study to develop a key function for the GGSEM and the GGSF, specifically, a solid particle cloud generating device. The breadboard design and test results are discussed and recommendations for further studies are included. The GGSEM is intended to fly on board a low earth orbit (LEO), manned platform. It will be used to perform a subset of the experiments planned for the GGSF for Space Station Freedom, as it can partially accommodate a number of the science experiments. The outcome of the experiments performed will provide an increased understanding of the operational requirements for the GGSF. The GGSEM will also act as a platform to accomplish technology development and proof-of-principle experiments for GGSF hardware, and to verify concepts and designs of hardware for GGSF. The GGSEM will allow assembled subsystems to be tested to verify facility level operation. The technology development that can be accommodated by the GGSEM includes: GGSF sample generation techniques, GGSF on-line diagnostics techniques, sample collection techniques, performance of various types of sensors for environmental monitoring, and some off-line diagnostics. Advantages and disadvantages of several LEO platforms available for GGSEM applications are identified and discussed. Several of the anticipated GGSF experiments require the de-agglomeration and dispensing of dry solid particles into an experiment chamber. During the GGSF Phase A study, various techniques and devices available for the solid particle aerosol generator were reviewed. As a result of this review, solid particle de-agglomeration and dispensing were identified as key undeveloped technologies in the GGSF design. A laboratory breadboard version of a solid

  19. Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes

    Science.gov (United States)

    Ferguson, David J. P.; Kaindama, Mbinda L.; Brusini, Lorenzo; Joshi, Nimitray; Rchiad, Zineb; Brady, Declan; Guttery, David S.; Wheatley, Sally P.; Yamano, Hiroyuki; Holder, Anthony A.; Pain, Arnab; Wickstead, Bill; Tewari, Rita

    2015-01-01

    Cell-cycle progression and cell division in eukaryotes are governed in part by the cyclin family and their regulation of cyclin-dependent kinases (CDKs). Cyclins are very well characterised in model systems such as yeast and human cells, but surprisingly little is known about their number and role in Plasmodium, the unicellular protozoan parasite that causes malaria. Malaria parasite cell division and proliferation differs from that of many eukaryotes. During its life cycle it undergoes two types of mitosis: endomitosis in asexual stages and an extremely rapid mitotic process during male gametogenesis. Both schizogony (producing merozoites) in host liver and red blood cells, and sporogony (producing sporozoites) in the mosquito vector, are endomitotic with repeated nuclear replication, without chromosome condensation, before cell division. The role of specific cyclins during Plasmodium cell proliferation was unknown. We show here that the Plasmodium genome contains only three cyclin genes, representing an unusual repertoire of cyclin classes. Expression and reverse genetic analyses of the single Plant (P)-type cyclin, CYC3, in the rodent malaria parasite, Plasmodium berghei, revealed a cytoplasmic and nuclear location of the GFP-tagged protein throughout the lifecycle. Deletion of cyc3 resulted in defects in size, number and growth of oocysts, with abnormalities in budding and sporozoite formation. Furthermore, global transcript analysis of the cyc3-deleted and wild type parasites at gametocyte and ookinete stages identified differentially expressed genes required for signalling, invasion and oocyst development. Collectively these data suggest that cyc3 modulates oocyst endomitotic development in Plasmodium berghei. PMID:26565797

  20. Development of additional module to neutron-physic and thermal-hydraulic computer codes for coolant acoustical characteristics calculation

    Energy Technology Data Exchange (ETDEWEB)

    Proskuryakov, K.N.; Bogomazov, D.N.; Poliakov, N. [Moscow Power Engineering Institute (Technical University), Moscow (Russian Federation)

    2007-07-01

    The new special module to neutron-physic and thermal-hydraulic computer codes for coolant acoustical characteristics calculation is worked out. The Russian computer code Rainbow has been selected for joint use with a developed module. This code system provides the possibility of EFOCP (Eigen Frequencies of Oscillations of the Coolant Pressure) calculations in any coolant acoustical elements of primary circuits of NPP. EFOCP values have been calculated for transient and for stationary operating. The calculated results for nominal operating were compared with results of measured EFOCP. For example, this comparison was provided for the system: 'pressurizer + surge line' of a WWER-1000 reactor. The calculated result 0.58 Hz practically coincides with the result of measurement (0.6 Hz). The EFOCP variations in transients are also shown. The presented results are intended to be useful for NPP vibration-acoustical certification. There are no serious difficulties for using this module with other computer codes.

  1. Development of additional module to neutron-physic and thermal-hydraulic computer codes for coolant acoustical characteristics calculation

    International Nuclear Information System (INIS)

    Proskuryakov, K.N.; Bogomazov, D.N.; Poliakov, N.

    2007-01-01

    The new special module to neutron-physic and thermal-hydraulic computer codes for coolant acoustical characteristics calculation is worked out. The Russian computer code Rainbow has been selected for joint use with a developed module. This code system provides the possibility of EFOCP (Eigen Frequencies of Oscillations of the Coolant Pressure) calculations in any coolant acoustical elements of primary circuits of NPP. EFOCP values have been calculated for transient and for stationary operating. The calculated results for nominal operating were compared with results of measured EFOCP. For example, this comparison was provided for the system: 'pressurizer + surge line' of a WWER-1000 reactor. The calculated result 0.58 Hz practically coincides with the result of measurement (0.6 Hz). The EFOCP variations in transients are also shown. The presented results are intended to be useful for NPP vibration-acoustical certification. There are no serious difficulties for using this module with other computer codes

  2. Development of a multi-channel front-end electronics module based on ASIC for silicon strip array detectors

    International Nuclear Information System (INIS)

    Zhao Xingwen; Yan Duo; Su Hong; Qian Yi; Kong Jie; Zhang Xueheng; Li Zhankui; Li Haixia

    2014-01-01

    The silicon strip array detector is one of external target facility subsystems in the Cooling Storage Ring on the Heavy Ion Research Facility at Lanzhou (HIRFL-CSR). Using the ASICs, the front-end electronics module has been developed for the silicon strip array detectors and can implement measurement of energy of 96 channels. The performance of the front-end electronics module has been tested. The energy linearity of the front-end electronics module is better than 0.3% for the dynamic range of 0.1∼0.7 V. The energy resolution is better than 0.45%. The maximum channel crosstalk is better than 10%. The channel consistency is better than 1.3%. After continuously working for 24 h at room temperature, the maximum drift of the zero-peak is 1.48 mV. (authors)

  3. Development of an x-ray klystron modulator with a pulse-forming line and magnetic switch

    International Nuclear Information System (INIS)

    Akemoto, M.; Takeda, S.

    1992-01-01

    A new type of klystron modulator has been developed for the Japan Linear Collider. It consists of a pulse-forming line (PFL), a pulse transformer and a magnetic switch. In order to realize a compact modulator, a triplate strip transmission line using deionized water as a dielectric was adapted. An Fe amorphous core was used for the magnetic switch and the pulse transformer to reduce the size and cost. A preliminary test has shown that an output pulse with a peak voltage of 550 kV, a pulse length (flat-top) of 440 ns and a rise time of 165 ns can be generated for a dummy load with an impedance of 412Ω. It was also experimentally confirmed that the power efficiency of the modulator is approximately 83%. (Author) 7 figs., 3 tabs., 2 refs

  4. Responding empathically to patients: Development, implementation, and evaluation of a communication skills training module for oncology nurses.

    Science.gov (United States)

    Pehrson, Cassandra; Banerjee, Smita C; Manna, Ruth; Shen, Megan Johnson; Hammonds, Stacey; Coyle, Nessa; Krueger, Carol A; Maloney, Erin; Zaider, Talia; Bylund, Carma L

    2016-04-01

    The purpose of this paper is to report on the development, implementation, and evaluation of a Communication Skills Training (CST) module for inpatient oncology nurses on how to respond empathically to patients. 248 nurses from a USA cancer center participated in a CST module on responding empathically to patients. Nurses completed pre- and post-training Standardized Patient Assessments (SPAs), a survey on their confidence in and intent to utilize skills taught, and a six-month post-training survey of self-reported use of skills. Results indicate that nurses were satisfied with the module, reporting that agreement or strong agreement to 5 out of 6 items assessing satisfaction 96.7%-98.0% of the time. Nurses' self-efficacy in responding empathically significantly increased pre- to post-training. Additionally, nurses showed empathy skill improvement in the post-SPAs. Finally, 88.2% of nurses reported feeling confident in using the skills they learned post-training and reported an increase of 42-63% in the use of specific empathic skills. A CST module for nurses in responding empathically to patients showed feasibility, acceptability, and improvement in self-efficacy as well as skill uptake. This CST module provides an easily targeted intervention for improving nurse-patient communication and patient-centered care. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  5. Method for Backplane Data Communication with the VME Rear Transition Modules Developed for the ATLAS FTK Project

    CERN Document Server

    Bogdan, M; The ATLAS collaboration; Piendibene, M; Shochet, M; Tompkins, L

    2013-01-01

    This paper presents a method to achieve backplane data transfer capabilities to and from a VME Rear Transition Module (RTM), while being in full compliance with the VME64/VIPA Specification. The VMEbus is specified for data transfers only with boards plugged on the front side of the subrack. The RTMs receive power from the crate, but are not part of the actual data transfer bus. They do not plug into the J1 connector, and have no access to backplane interface logic. In this implementation, the RTM uses the feed-through pins located in the J2 connector to communicate with the corresponding front module. The front module's internal data, address, and control buses are extended to the rear. This allows the front module's interface block to control data transfers for logic devices on both sides of the same slot. All usual VME protocols to logic devices on the RTM become possible without any software adaptation. This method was implemented on several prototype modules developed for the ATLAS FTK Project. The full ...

  6. Fiscal 1999 research and development of technologies for practical application of photovoltaic power generation systems. Research and development of photovoltaic power utilizing system and peripheral technologies (Research and development of novel type solar cell module integratable with building materials - Highly durable roof module); 1999 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu seika hokokusho. Taiyoko hatsuden riyo system shuhen gijutsu no kenkyu kaihatsu (shinkenzai ittaigata taiyo denchi module no kenkyu kaihatsu - kotaikyusei yane module)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    A thin-film solar array, a large roof panel, and an interconnecting power conditioner are integrated into one and single structural member for the development of a residential photovoltaic power system in which a unit AC (alternating current) output is collected from each panel. In fiscal 1999, in the study of highly durable materials for solar cell modules and of their structure, a thin film compound solar cell module was enlarged to 82cm times 71cm, evaluated for performance, and installed on the third test house. In the study of collecting AC power from the solar cell module, a compact power conditioner for a roof panel which had been in test operation on the roof of the laboratory since 1998 was checked for practical performance, improved, and evaluated for system generation efficiency. In the study of a highly durable roof module structure, problems pertaining to heat radiation from the rear side steel sheet, the burning of the junction box, etc., were solved, and the module passed a verification test under the Building Standard Law. In the validation of the roof module for which power generation performance and meteorological conditions had already been continuously measured for 19 months, it was found that the roof module suffered no troubles such as water leak or deformation. (NEDO)

  7. Monte Carlo treatment planning with modulated electron radiotherapy: framework development and application

    Science.gov (United States)

    Alexander, Andrew William

    Within the field of medical physics, Monte Carlo radiation transport simulations are considered to be the most accurate method for the determination of dose distributions in patients. The McGill Monte Carlo treatment planning system (MMCTP), provides a flexible software environment to integrate Monte Carlo simulations with current and new treatment modalities. A developing treatment modality called energy and intensity modulated electron radiotherapy (MERT) is a promising modality, which has the fundamental capabilities to enhance the dosimetry of superficial targets. An objective of this work is to advance the research and development of MERT with the end goal of clinical use. To this end, we present the MMCTP system with an integrated toolkit for MERT planning and delivery of MERT fields. Delivery is achieved using an automated "few leaf electron collimator" (FLEC) and a controller. Aside from the MERT planning toolkit, the MMCTP system required numerous add-ons to perform the complex task of large-scale autonomous Monte Carlo simulations. The first was a DICOM import filter, followed by the implementation of DOSXYZnrc as a dose calculation engine and by logic methods for submitting and updating the status of Monte Carlo simulations. Within this work we validated the MMCTP system with a head and neck Monte Carlo recalculation study performed by a medical dosimetrist. The impact of MMCTP lies in the fact that it allows for systematic and platform independent large-scale Monte Carlo dose calculations for different treatment sites and treatment modalities. In addition to the MERT planning tools, various optimization algorithms were created external to MMCTP. The algorithms produced MERT treatment plans based on dose volume constraints that employ Monte Carlo pre-generated patient-specific kernels. The Monte Carlo kernels are generated from patient-specific Monte Carlo dose distributions within MMCTP. The structure of the MERT planning toolkit software and

  8. The Development Of Learning Sets And Research Methodology Module Using Problem Based Learning For Accounting Education Students

    OpenAIRE

    Thomas, Partono; Nurkhin, Ahmad

    2016-01-01

    Improving the learning process is very important for every lecturer by implement innovative learning methods or media. The purpose of this study is to develop a research methodology learning instruction and module based of problem based learning for accounting education students. This research applied research and development design in the research methodology course in Economics Education (Accounting) Department, Faculty Of Economics, Semarang State University. Data analysis was used to test...

  9. Progress on the Fabrication Methods Development for the Korean Test Blanket Module First Wall in the ITER

    International Nuclear Information System (INIS)

    Lee, Dong Won; Kim, Suk Kwon; Bae, Young Dug; Yoon, Jae Sung; Cho, Seung Yon

    2010-01-01

    A Korean helium cooled molten lithium (HCML) test blanket module (TBM) has been designed to be tested in the International Thermonuclear Experimental Reactor (ITER) TBM and related fabrication methods have been developed especially for the purpose of joining. Since the first wall (FW) of the HCML TBM is composed of a beryllium (Be) as an armor material and a FMS as a structural one, joining with Be to FMS and FMS to FMS should be developed in order to fabricate it

  10. Module Integrated GaN Power Stage for High Switching Frequency Operation

    DEFF Research Database (Denmark)

    Nour, Yasser; Knott, Arnold

    2017-01-01

    is integrated on a high glass transition temperature 0.4 mmthick FR4 substrate configured as a 70 pin ball grid arraypackage. The power stage is tested up to switching frequency of12 MHz. The power stage achieved 88.5 % peak efficiency whenconfigured as a soft switching buck converter operating at 7MHz......An increased attention has been detected todevelop smaller and lighter high voltage power converters in therange of 50 V to 400 V domains. The applications for theseconverters are mainly focused for Power over Ethernet (PoE),LED lighting and ac adapters. Design for high power density isone...... of the targets for next generation power converters. Thispaper presents an 80 V input capable multi-chip moduleintegration of enhancement mode gallium nitride (GaN) fieldeffect transistors (FETs) based power stage. The module design ispresented and validated through experimental results. The powerstage...

  11. Dynamical patterning modules: physico-genetic determinants of morphological development and evolution

    International Nuclear Information System (INIS)

    Newman, Stuart A; Bhat, Ramray

    2008-01-01

    The shapes and forms of multicellular organisms arise by the generation of new cell states and types and changes in the numbers and rearrangements of the various kinds of cells. While morphogenesis and pattern formation in all animal species are widely recognized to be mediated by the gene products of an evolutionarily conserved 'developmental-genetic toolkit', the link between these molecular players and the physics underlying these processes has been generally ignored. This paper introduces the concept of 'dynamical patterning modules' (DPMs), units consisting of one or more products of the 'toolkit' genes that mobilize physical processes characteristic of chemically and mechanically excitable meso- to macroscopic systems such as cell aggregates: cohesion, viscoelasticity, diffusion, spatiotemporal heterogeneity based on lateral inhibition and multistable and oscillatory dynamics. We suggest that ancient toolkit gene products, most predating the emergence of multicellularity, assumed novel morphogenetic functions due to change in the scale and context inherent to multicellularity. We show that DPMs, acting individually and in concert with each other, constitute a 'pattern language' capable of generating all metazoan body plans and organ forms. The physical dimension of developmental causation implies that multicellular forms during the explosive radiation of animal body plans in the middle Cambrian, approximately 530 million years ago, could have explored an extensive morphospace without concomitant genotypic change or selection for adaptation. The morphologically plastic body plans and organ forms generated by DPMs, and their ontogenetic trajectories, would subsequently have been stabilized and consolidated by natural selection and genetic drift. This perspective also solves the apparent 'molecular homology-analogy paradox', whereby widely divergent modern animal types utilize the same molecular toolkit during development by proposing, in contrast to the Neo

  12. Development of a Respiratory Inductive Plethysmography Module Supporting Multiple Sensors for Wearable Systems

    Directory of Open Access Journals (Sweden)

    Zhengbo Zhang

    2012-09-01

    Full Text Available In this paper, we present an RIP module with the features of supporting multiple inductive sensors, no variable frequency LC oscillator, low power consumption, and automatic gain adjustment for each channel. Based on the method of inductance measurement without using a variable frequency LC oscillator, we further integrate pulse amplitude modulation and time division multiplexing scheme into a module to support multiple RIP sensors. All inductive sensors are excited by a high-frequency electric current periodically and momentarily, and the inductance of each sensor is measured during the time when the electric current is fed to it. To improve the amplitude response of the RIP sensors, we optimize the sensing unit with a matching capacitor parallel with each RIP sensor forming a frequency selection filter. Performance tests on the linearity of the output with cross-sectional area and the accuracy of respiratory volume estimation demonstrate good linearity and accurate lung volume estimation. Power consumption of this new RIP module with two sensors is very low. The performance of respiration measurement during movement is also evaluated. This RIP module is especially desirable for wearable systems with multiple RIP sensors for long-term respiration monitoring.

  13. Integration of the ATHENA mirror modules: development of indirect and x-ray direct AIT methods

    Science.gov (United States)

    Vernani, Dervis; Blum, Steffen; Seure, Thibault; Bavdaz, Marcos; Wille, Eric; Schaeffer, Uwe; Lièvre, Nicolas; Nazeeruddin, Adeeb; Barrière, Nicolas M.; Collon, Maximilien J.; Cibik, Levent; Krumrey, Michael; Müller, Peter; Burwitz, Vadim

    2017-08-01

    Within the ATHENA optics technology plan, activities are on-going for demonstrating the feasibility of the mirror module Assembly Integration and Testing (AIT). Each mirror module has to be accurately attached to the mirror structure by means of three isostatic mounts ensuring minimal distortion under environmental loads. This work reports on the status of one of the two parallel activities initiated by ESA to address this demanding task. In this study awarded to the industrial consortium, the integration relies on opto-mechanical metrology and direct X-ray alignment. For the first or "indirect" method the X-ray alignment results are accurately referenced, by means of a laser tracking system, to optical fiducial targets mounted on the mirror modules and finally linked to the mirror structure coordinate system. With the second or "direct" method the alignment is monitored in the X-ray domain, providing figures of merit directly comparable to the final performance. The integration being designed and here presented, foresees combining the indirect method to the X-ray direct method. The characterization of the single mirror modules is planned at PTB's X-ray Parallel Beam Facility (XPBF 2.0) at BESSY II, and the integration and testing campaign at Panter. It is foreseen to integrate and test a demonstrator with two real mirror modules manufactured by cosine.

  14. Development of the MCM-D technique for pixel detector modules

    International Nuclear Information System (INIS)

    Grah, C.

    2005-03-01

    This thesis treats a copper--polymer based thin film technology, the MCM-D technique and its application when building hybrid pixel detector modules. The ATLAS experiment at the LHC will be equipped with a pixel detector system. The basic mechanical units of the pixel detector are multi chip modules. The main components of these modules are: 16 electronic chips, a controller chip and a large sensor tile, featuring more than 46000 sensor cells. MCM-D is a superior technique to build the necessary signal bus system and the power distribution system directly on the active sensor tile. In collaboration with the Fraunhofer Institute for Reliability and Microintegration, IZM, the thin film process is reviewed and enhanced. The multi layer system was designed and optimized for the interconnection system as well as for the 46000 pixel contacts. Laboratory measurements on prototypes prove that complex routing schemes for geometrically optimized single chips are suitable and have negligible influence on the front--end chips performance. A full scale MCM-D module has been built and it is shown that the technology is suitable to build pixel detector modules. Further tests include the investigation of the impact of hadronic irradiation on the thin film layers. Single chip assemblies have been operated in a test beam environment and the feasibility of the optimization of the sensors could be shown. A review on the potential as well as the perspective for the MCM-D technique in future experiments is given

  15. Development of 8 MW Power Supply Based on Pulse Step Modulation Technique for Auxiliary Heating System on HL-2A

    International Nuclear Information System (INIS)

    Xu Weidong; Xuan Weimin; Yao Lieying; Wang Yingqiao

    2012-01-01

    The high voltage power supply (HVPS) based on pulse step modulation (PSM) has already been developed for the auxiliary heating system on HL-2A. This power supply consists of many switch power supplies, and its output voltage can be obtained by modulating their delay time and pulse widths. The PSM topology and control principle are presented in this paper. The simple algorithms for the control system are explained clearly. The switch power supply (SPS) module has been built and the test results show it can meet the requirements of the auxiliary heating system. Now, 112 SPS modules and the whole system have already been developed. Its maximum output is about 72 kV/93 A. The protection time is less than 5 μs. The different outputs of this power supply are used for the electron cyclotron resonant heating (ECRH) system with different duty ratios. The experimental results of the entire system are presented. The results indicate that the whole system can meet the requirements of the auxiliary heating system on HL-2A.

  16. Children's Food and Drink Purchasing Behaviour “Beyond the School Gate”: The Development of a Survey Module

    Science.gov (United States)

    Wills, Wendy J.; Macdiarmid, Jennie I.; Masson, Lindsey F.; McNeill, Geraldine

    2013-01-01

    Many children eat a diet which supplies a higher than recommended amount of nonmilk extrinsic sugars and saturated fatty acids. The school setting is often targeted for nutrition intervention as many children consume food at school. In Scotland, attempts have been made to improve the nutritional content of food in schools and attention has now turned to food and drink available “beyond the school gate.” This paper describes the development of a module on food and drink purchasing behaviour. The Food Purchasing Module was designed to collect data, for the first time, from a representative sample of children aged 8–16 years about food and drinks purchased on the way to/from school, during break time/free periods, and at lunchtime, from outlets around schools. Cognitive testing of the module highlighted that younger children find self-completion questionnaires problematic. Older children have fewer problems with self-completion questionnaires but many do not follow question routing, which has implications for the delivery of future surveys. Development of this survey module adds much needed evidence about effectively involving children in surveys. Further research exploring food and drinks purchased beyond the school gate is needed to continue to improve the nutritional quality of children's diets. PMID:24959546

  17. Design and development of FPGA based TCP/IP module for real time computers in nuclear power plants

    International Nuclear Information System (INIS)

    Balasri, G. Janani; Santhana Raj, A.; Gour, Aditya; Murali, N.; Manikandan, J.

    2013-01-01

    An VME (Virtual Module Europa) bus based Real Time Computer's (RTC's) are being developed for Prototype Fast Breeder Reactor (PFBR) which is in an advanced stage of construction at Kalpakkam, where the RTC's have to communicate to the central process computer on the data collected from the field instrument and receive data from the central process computer. A Distributed Digital Control System (DDSC) architecture has been designed for this communication which is based on Transfer Communication Protocol/Internet Protocol (TCP/IP) over Ethernet. Currently the RTC's uses 'Wiznet Module', a bought out chip which implements the TCP/IP stack in hardware. This project concentrates on the design and development of Field Programmable Gate Array (FPGA) based TCP/IP module that runs on Microblaze, a 32-bit softcore processor, to take care of the communication as that of Wiznet module. Advantage of switching over to FPGA based system are its reconfigurability, desired number of sockets, and the design is stable even if the FPGA's get obsolete. (author)

  18. Design and development of CAMAC 12 bit ADC/DAC dual purpose module

    International Nuclear Information System (INIS)

    Kulkarni, S.G.; Gore, J.A.; Ramlal, V.; Matkar, U.V.; Lokare, R.N.; Yadav, M.L.; Ekambaram, M.; Gupta, A.K.; Datar, V.M.

    2013-01-01

    A dual function CAMAC module is designed for Pelletron Accelerator which can function as 12 bit 8 channels DAC or 12 bit 16 channels ADC. Spartan 2 series of FPGA is used for implementing the CAMAC interface logic as well as logic for ADC/DAC interface. The PCB has both the ADC and DAC mounted but the module can have only one function selected due to wiring constraint. Two different VHDL programs (one for the ADC and other for the DAC) reside on the EEPROM permitting selection of any one as per the functionality required. The module is working as a 12 bit DAC at BARC-TIFR Pelletron Linac Facility, successfully. (author)

  19. Design and Development of Multi-Transceiver Lorafi Board consisting LoRa and ESP8266-Wifi Communication Module

    Science.gov (United States)

    Azmi, Noraini; Sudin, Sukhairi; Munirah Kamarudin, Latifah; Zakaria, Ammar; Visvanathan, Retnam; Chew Cheik, Goh; Mamduh Syed Zakaria, Syed Muhammad; Abdullah Alfarhan, Khudhur; Badlishah Ahmad, R.

    2018-03-01

    The advancement of Micro-Electro-Mechanical-Systems (MEMS), microcontroller technologies and the idea of Internet of Things (IoT) motivates the development of wireless modules (e.g. WiFi, Bluetooth, Zigbee, and LoRa) that are small and affordable. This paper aims to provide detailed information on the development of the LoRaFi board. The LoRaFi 1.0 is a multi-protocol communication board developed by Centre of Excellence for Advanced Sensor Technology (CEASTech). The board was developed for but not limited to monitor the indoor air quality. The board comprises two different wireless communication modules namely, Long-range technology (LoRa) and WiFi (using ESP8266). The board can be configured to communicate either using LoRa or WiFi or both. The board has been tested and the wireless communication operates successfully. Apart from LoRa, WiFi enables data to be forwarded to the cloud/server where the data can be stored for further data analysis. This helps provide users with real-time information on their smartphones or other applications. In the future, researchers will conduct tests to investigate the communication link quality. Newer version with reduced board size and additional wireless communication module will be developed in the future as to increase board flexibility and widen the range of applications that can use the board.

  20. Development of GPCR modulation of GABAergic transmission in chicken nucleus laminaris neurons.

    Directory of Open Access Journals (Sweden)

    Zheng-Quan Tang

    Full Text Available Neurons in the nucleus laminaris (NL of birds act as coincidence detectors and encode interaural time difference to localize the sound source in the azimuth plane. GABAergic transmission in a number of CNS nuclei including the NL is subject to a dual modulation by presynaptic GABA(B receptors (GABA(BRs and metabotropic glutamate receptors (mGluRs. Here, using in vitro whole-cell patch clamp recordings from acute brain slices of the chick, we characterized the following important but unknown properties pertaining to such a dual modulation: (1 emergence of functional GABA synapses in NL neurons; (2 the temporal onset of neuromodulation mediated by GABA(BRs and mGluRs; and (3 the physiological conditions under which GABA(BRs and mGluRs are activated by endogenous transmitters. We found that (1 GABA(AR-mediated synaptic responses were observed in about half of the neurons at embryonic day 11 (E11; (2 GABA(BR-mediated modulation of the GABAergic transmission was detectable at E11, whereas the modulation by mGluRs did not emerge until E15; and (3 endogenous activity of GABA(BRs was induced by both low- (5 or 10 Hz and high-frequency (200 Hz stimulation of the GABAergic pathway, whereas endogenous activity of mGluRs was induced by high- (200 Hz but not low-frequency (5 or 10 Hz stimulation of the glutamatergic pathway. Furthermore, the endogenous activity of mGluRs was mediated by group II but not group III members. Therefore, autoreceptor-mediated modulation of GABAergic transmission emerges at the same time when the GABA synapses become functional. Heteroreceptor-mediated modulation appears at a later time and is receptor type dependent in vitro.

  1. Development of teaching modules for geology and engineering coursework using terrestrial LiDAR scanning systems

    Science.gov (United States)

    Yarbrough, L. D.; Katzenstein, K.

    2012-12-01

    of designed engineering solutions. These course learning modules were developed for traditional geological engineering courses delivered on campus, for more intensive field work courses and online-based asynchronous course delivery.

  2. Development of horn antenna mixer array with internal local oscillator module for microwave imaging diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Kuwahara, D., E-mail: dkuwahar@cc.tuat.ac.jp [Department of Mechanical Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588 (Japan); Ito, N. [Department of Intelligent System Engineering, Ube National College of Technology, Ube, Yamaguchi 755-8555 (Japan); Nagayama, Y. [Department of Helical Plasma Research, National Institute for Fusion Science, Toki, Gifu 509-5292 (Japan); Yoshinaga, T. [Department of Applied Physics, National Defense Academy, Yokosuka, Kanagawa 239-0811 (Japan); Yamaguchi, S. [Department of Pure and Applied Physics, Kansai University, Suita, Osaka 564-8680 (Japan); Yoshikawa, M.; Kohagura, J. [Graduate School of Pure and Applied Science, University of Tsukuba, Tsukuba, Ibaraki 305-8577 (Japan); Sugito, S. [Equipment Development Center, Institute for Molecular Science, Okazaki, Aichi 444-8585 (Japan); Kogi, Y. [Department of Information Electronics, Fukuoka Institute of Technology, Fukuoka, Fukuoka 811-0295 (Japan); Mase, A. [Art, Science and Technology Center for Cooperative Research, Kyusyu University, Kasuga, Fukuoka 816-8580 (Japan)

    2014-11-15

    A new antenna array is proposed in order to improve the sensitivity and complexity of microwave imaging diagnostics systems such as a microwave imaging reflectometry, a microwave imaging interferometer, and an electron cyclotron emission imaging. The antenna array consists of five elements: a horn antenna, a waveguide-to-microstrip line transition, a mixer, a local oscillation (LO) module, and an intermediate frequency amplifier. By using an LO module, the LO optics can be removed, and the supplied LO power to each element can be equalized. We report details of the antenna array and characteristics of a prototype antenna array.

  3. Development and Calibration of the ART-XC Mirror Modules for the Spectrum Rontgen Gamma Mission

    Science.gov (United States)

    Ramsey, B.; Gubarev, M.; Elsner, R.; Kolodziejczak, J.; Odell, S.; Swartz, D.; Pavlinsky, M.; Tkachenko, A.; Lapshov, I.

    2013-01-01

    The Spectrum-Röntgen-Gamma (SRG) mission is a Russian-lead X-ray astrophysical observatory that carries two co-aligned X-ray telescope systems. The primary instrument is the German-led extended ROentgen Survey with an Imaging Telescope Array (eROSITA), a 7-module X-ray telescope system that covers the energy range from 0.2-12 keV. The complementary instrument is the Astronomical Roentgen Telescope -- X-ray Concentrator (ART-XC or ART), a 7-module Xray telescope system that provides higher energy coverage, up to 30 keV.

  4. Fast Convolution Module (Fast Convolution Module)

    National Research Council Canada - National Science Library

    Bierens, L

    1997-01-01

    This report describes the design and realisation of a real-time range azimuth compression module, the so-called 'Fast Convolution Module', based on the fast convolution algorithm developed at TNO-FEL...

  5. Price development of photovoltaic modules, inverters, and systems in the Netherlands in 2012

    NARCIS (Netherlands)

    Van Sark, Wilfried G J H M; Muizebelt, Peter; Cace, Jadranka; de Vries, Arthur; de Rijk, Peer

    2014-01-01

    Since 2010 the Dutch photovoltaic (PV) market has been growing fast, with around doubling of installed capacity in 2011 and 2012. Four quarterly inventories have been made in 2012 for modules, inverters, and systems that are presently available for purchase in the Netherlands. We have found that the

  6. Price Development of Photovoltaic Modules, Inverters and Systems in the Netherlands

    NARCIS (Netherlands)

    Sark, W.G.J.H.M. van; Muizebelt, P.; Cace, J.; Vries, A. de; Rijk, P. de

    2014-01-01

    Since 2010 the Dutch photovoltaic (PV) market has been growing fast, with around doubling of installed capacity in 2011 and 2012. Four quarterly inventories have been made in 2012 for modules, inverters, and systems that are presently available for purchase in the Netherlands. We have found that

  7. Aquatic Nutrient Simulation Modules (NSMs) Developed for Hydrologic and Hydraulic Models

    Science.gov (United States)

    2016-02-01

    deter- mined by a linear equilibrium partitioning isotherm. In the sediment bed, if the optional sediment diagenesis module is included (see Chapter... opal , sediment and seawater in the central equatorial Pacific. Geochimica et Cosmochimica 37:2257–2282. Jobson, H. E. 1977. Bed conduction

  8. Scheduling language and algorithm development study. Volume 2: Use of the basic language and module library

    Science.gov (United States)

    Chamberlain, R. A.; Cornick, D. E.; Flater, J. F.; Odoherty, R. J.; Peterson, F. M.; Ramsey, H. R.; Willoughby, J. K.

    1974-01-01

    The capabilities of the specified scheduling language and the program module library are outlined. The summary is written with the potential user in mind and, therefore, provides maximum insight on how the capabilities will be helpful in writing scheduling programs. Simple examples and illustrations are provided to assist the potential user in applying the capabilities of his problem.

  9. Toward Eco Product Development with Qualitative and CAE Design Process - Case Study of Flame Guiding Module

    Science.gov (United States)

    Chen, W. L.; Chao, F. L.

    2018-04-01

    Sustainable products become increasingly important for company in addressing eco-performance to satisfy global environmental regulations. Case study of flame guiding module reviewed design process and concerns related to the torch design. For enhancing flame height, the torch was embedded with an airflow guidance structure. The design process and design methodologies were investigated as an eco-design case study. Combine qualitative and CAE simulation were proposed to fulfil its main and auxiliary functions including reduction of impact during use. The design guidelines help prevent mistake arrangements, CAE helps understand combustion phenomenon. The flow field simulation enables fine tune of geometric design. Functional test and measurement are carried out to confirm the product features. On Eco-performance, we choose 5 items for evaluation the status of previous and redesign module, namely function need, low impact material, few manufacturing steps, low energy consumption, and safety. The radar diagram indicates that eco-performance of redesign module is better. Life cycle assessment calculated the carbon footprint of the manufacturing and processing stage with Eco-it. By using recycled steel in the flame module, it reduces raw material stage carbon footprint significantly.

  10. Development of Chemistry Triangle Oriented Module on Topic of Reaction Rate for Senior High School Level Grade XI Chemistry Learning.

    Science.gov (United States)

    Sari, D. R.; Hardeli; Bayharti

    2018-04-01

    This study aims to produce chemistry triangle oriented module on topic of reaction rate, and to reveal the validity and practicality level of the generated module. The type of research used is EducationalDesign Research (EDR) with development model is Plompmodel. This model consists of three phases, which are preliminary research, prototyping phase, and assessment phase. The instrument used in this research is questionnaire validity and practicality. The data of the research were analyzed by using Kappa Cohen formula. The chemistry triangle oriented module validation sheet was given to 5 validators consisting of 3 chemistry lecturers and 2 high school chemistry teachers, while the practicality sheet was given to 2 chemistry teachers, 6 students of SMAN 10 Padang grade XII MIA 5 on the small groupevaluation and 25 students of SMAN 10 Padang grade XII MIA 6 on the field test. Based on the questionnaire validity analysis, the validity level of the module is very high with the value of kappa moment 0.87. The level of practicality based on teacher questionnaire response is very high category with a kappa moment value 0.96. Based on the questionnaire of student responses on small group evaluation, the level of practicality is very high category with a kappa moment 0.81, and the practicality is very high category with kappa moment value 0.83 based on questionnaire of student response on field test.

  11. Development of filter module for passive filtration and accident gas release confinement system for NPP

    International Nuclear Information System (INIS)

    Yelizarov, P.G.; Efanov, A.D.; Martynov, P.N.; Masalov, D.P.; Osipov, V.P.; Yagodkin, I.V.

    2005-01-01

    Full text of publication follows: One of the urgent problems of the safe NPP operation is air cleaning from radioactive aerosols and volatile iodine compounds under the accident operation conditions of NPP. A principally new passive accident gas release confinement system is used as the basis of the designs of new generation reactor power blocks under the-beyond-design-basis accident conditions with total loss of current. The basic structural component of the passive filtration system (PFS) is the filter-sorber being heated up to 300 deg. C. The filter-sorber represents a design consisting of 150 connected in parallel two-step filtering modules. The first step is intended to clean air from radioactive aerosols, the second one - to clean air from radioactive iodine and its volatile compounds. The filter-sorber is located in the upper point of the exterior protection shell. Due to natural convection, it provides confinement of r/a impurities and controlled steam-gas release from the inter-shell space into atmosphere. The basic specific design feature is the two-section design of the PFS filter module consisting of a coarse-cleaning section and a fine-cleaning section. A combination of layer-by-layer put filtering materials on the basis of glass fiber and metal fiber. The pilot PFS filter module specimen tests run in conditions modeling accident situation indicated that at a filtration rate of 0,3 cm/s the aerodynamic resistance of the module does not exceed 12 Pa, the filtration effectiveness equals 99,99 % in terms of aerosol, no less than 99,9% in terms of radioactive 131 I and no less than 99,0% in terms of organic compounds of iodine (CH 3 131 I); the dust capacity amounts to a value above 50 g/m 2 . The obtained results of tests comply with the design requirements imposed on the PFS filter-sorber module. (authors)

  12. Development of two U.H.F. band resonators for application to CO2 laser electro-optical modulation

    International Nuclear Information System (INIS)

    Egan, M.G.; Blanc, P.; Sexton, M.C.

    1980-01-01

    The purpose of this report is to describe the design and testing of two U.H.F. band resonators destined for use in the linear electro-optical modulator of the CO 2 Laser Rapid Interferometer diagnostic at present under development for the WEGA Tokamak. The resonators take the form of a re-entrant coaxial line cavity and an interdigital line filter, both of which possess the regions of high electric field necessary to activate the linear electro-optical effect

  13. Process development for automated solar cell and module production. Task 4. Automated array assembly. Quarterly report No. 1

    Energy Technology Data Exchange (ETDEWEB)

    Hagerty, J. J.

    1980-10-15

    Work has been divided into five phases. The first phase is to modify existing hardware and controlling computer software to: (1) improve cell-to-cell placement accuracy, (2) improve the solder joint while reducing the amount of solder and flux smear on the cell's surface, and (3) reduce the system cycle time to 10 seconds. The second phase involves expanding the existing system's capabilities to be able to reject broken cells and make post-solder electrical tests. Phase 3 involves developing new hardware to allow for the automated encapsulation of solar modules. This involves three discrete pieces of hardware: (1) a vacuum platen end effector for the robot which allows it to pick up the 1' x 4' array of 35 inter-connected cells. With this, it can also pick up the cover glass and completed module, (2) a lamination preparation station which cuts the various encapsulation components from roll storage and positions them for encapsulation, and (3) an automated encapsulation chamber which interfaces with the above two and applies the heat and vacuum to cure the encapsulants. Phase 4 involves the final assembly of the encapsulated array into a framed, edge-sealed module completed for installation. For this we are using MBA's Glass Reinforced Concrete (GRC) in panels such as those developed by MBA for JPL under contract No. 955281. The GRC panel plays the multiple role of edge frame, substrate and mounting structure. An automated method of applying the edge seal will also be developed. The final phase (5) is the fabrication of six 1' x 4' electrically active solar modules using the above developed equipment. Progress is reported. (WHK)

  14. Modeling Tolerance Development for the Effect on Heart Rate of the Selective S1P1 Receptor Modulator Ponesimod.

    Science.gov (United States)

    Lott, Dominik; Lehr, Thorsten; Dingemanse, Jasper; Krause, Andreas

    2017-09-15

    Ponesimod is a selective sphingosine-1-phosphate-1 (S1P 1 ) receptor modulator currently under investigation for the treatment of multiple sclerosis. S1P receptor modulators reduce heart rate following treatment initiation. This effect disappears with repeated dosing, enabling development of innovative uptitration regimens to optimize patient safety. There are currently no published pharmacokinetic/pharmacodynamic models describing the heart rate reduction of S1P receptor modulators in humans. The model developed here provides quantification of this effect for ponesimod. A direct-effect I max model with estimated maximum reduction of 45%, tolerance development, and circadian variation best described this effect. The pooled data from nine clinical studies enabled characterization of interindividual variability. The model was used to simulate different treatment regimens to compare the effect of high initial doses vs. gradual uptitration with respect to the occurrence of bradycardia. The results indicate a better safety profile when using gradual uptitration. The model allows studying dosing regimens not clinically tested in silico. © 2017 American Society for Clinical Pharmacology and Therapeutics.

  15. Fiscal 1999 research and development of technologies for practical application of photovoltaic power generation systems. Research and development of photovoltaic power utilizing system and peripheral technologies (Research and development of novel type solar cell module integratable with building materials - Novel multilayer structure module); 1999 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu seika hokokusho. Taiyoko hatsuden riyo system shuhen gijutsu no kenkyu kaihatsu (shinkenzai ittaigata taiyo denchi module no kenkyu kaihatsu - shinfukuso kozo module)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    The project aims to develop solar cell modules of a novel multilayer structure, based on the resin filling structure, hollow structure, and the laminate structure, and integratable with building materials. In fiscal 1999, for the development of cells and submodule structures, cells and submodules were fabricated which were usable with various specimens. In the case of design oriented cells, electrode structures and linkage methods were improved for the enhancement of power generation performance, and a hollow structure and a laminate structure were fabricated. As for the 4m{sup 2}-large module (laminate structure), a specimen with dummy cells arranged along its periphery was fabricated. For cost reduction, a study was made about a module (laminate structure) integrated with an ALC (autoclaved lightweight concrete) board, and the kind of surface glass, cell arrangement, and back sheet types and their respective designs were evaluated. It was then concluded that the module was fit for practical application. The module was then checked for wind endurance in a wind endurance test, for electric characteristics, and for flame inhibition capability in a fire prevention/resistance test. (NEDO)

  16. Requirements for a Dynamic Solvent Extraction Module to Support Development of Advanced Technologies for the Recycle of Used Nuclear Fuel

    International Nuclear Information System (INIS)

    Law, Jack; Rutledge, Veronica; Pereira, Candido; Copple, Jackie; Frey, Kurt; Krebs, John; Maggos, Laura; Nichols, Kevin; Wardle, Kent; Sadasivan, Pratap; DeAlmieda, Valmor; Depaoli, David

    2011-01-01

    The Department of Energy's Nuclear Energy Advanced Modeling and Simulation (NEAMS) Program has been established to create and deploy next generation, verified and validated nuclear energy modeling and simulation capabilities for the design, implementation, and operation of future nuclear energy systems to improve the U.S. energy security. As part of the NEAMS program, Integrated Performance and Safety Codes (IPSC's) are being produced to significantly advance the status of modeling and simulation of energy systems beyond what is currently available to the extent that the new codes be readily functional in the short term and extensible in the longer term. The four IPSC areas include Safeguards and Separations, Reactors, Fuels, and Waste Forms. As part of the Safeguards and Separations (SafeSeps) IPSC effort, interoperable process models are being developed that enable dynamic simulation of an advanced separations plant. A SafeSepss IPSC 'toolkit' is in development to enable the integration of separation process modules and safeguards tools into the design process by providing an environment to compose, verify and validate a simulation application to be used for analysis of various plant configurations and operating conditions. The modules of this toolkit will be implemented on a modern, expandable architecture with the flexibility to explore and evaluate a wide range of process options while preserving their stand-alone usability. Modules implemented at the plant-level will initially incorporate relatively simple representations for each process through a reduced modeling approach. Final versions will incorporate the capability to bridge to subscale models to provide required fidelity in chemical and physical processes. A dynamic solvent extraction model and its module implementation are needed to support the development of this integrated plant model. As a stand-alone application, it will also support solvent development of extraction flowsheets and integrated

  17. Requirements for a Dynamic Solvent Extraction Module to Support Development of Advanced Technologies for the Recycle of Used Nuclear Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Jack Law; Veronica Rutledge; Candido Pereira; Jackie Copple; Kurt Frey; John Krebs; Laura Maggos; Kevin Nichols; Kent Wardle; Pratap Sadasivan; Valmor DeAlmieda; David Depaoli

    2011-06-01

    The Department of Energy's Nuclear Energy Advanced Modeling and Simulation (NEAMS) Program has been established to create and deploy next generation, verified and validated nuclear energy modeling and simulation capabilities for the design, implementation, and operation of future nuclear energy systems to improve the U.S. energy security. As part of the NEAMS program, Integrated Performance and Safety Codes (IPSC's) are being produced to significantly advance the status of modeling and simulation of energy systems beyond what is currently available to the extent that the new codes be readily functional in the short term and extensible in the longer term. The four IPSC areas include Safeguards and Separations, Reactors, Fuels, and Waste Forms. As part of the Safeguards and Separations (SafeSeps) IPSC effort, interoperable process models are being developed that enable dynamic simulation of an advanced separations plant. A SafeSepss IPSC 'toolkit' is in development to enable the integration of separation process modules and safeguards tools into the design process by providing an environment to compose, verify and validate a simulation application to be used for analysis of various plant configurations and operating conditions. The modules of this toolkit will be implemented on a modern, expandable architecture with the flexibility to explore and evaluate a wide range of process options while preserving their stand-alone usability. Modules implemented at the plant-level will initially incorporate relatively simple representations for each process through a reduced modeling approach. Final versions will incorporate the capability to bridge to subscale models to provide required fidelity in chemical and physical processes. A dynamic solvent extraction model and its module implementation are needed to support the development of this integrated plant model. As a stand-alone application, it will also support solvent development of extraction flowsheets

  18. Conditioned pain modulation: a predictor for development and treatment of neuropathic pain.

    Science.gov (United States)

    Granovsky, Yelena

    2013-09-01

    Psychophysical evaluation of endogenous pain inhibition via conditioned pain modulation (CPM) represents a new generation of laboratory tests for pain assessment. In this review we discuss recent findings on CPM in neuropathic pain and refer to psychophysical, neurophysiological, and methodological aspects of its clinical implications. Typically, chronic neuropathic pain patients express less efficient CPM, to the extent that incidence of acquiring neuropathic pain (e.g. post-surgery) and its intensity can be predicted by a pre-surgery CPM assessment. Moreover, pre-treatment CPM evaluation may assist in the correct choice of serotonin-noradrenalin reuptake inhibitor analgesic agents for individual patients. Evaluation of pain modulation capabilities can serve as a step forward in individualizing pain medicine.

  19. Development Module (Lab Report) As a Media of Learning in Vocational Education Viewed by Gender

    Science.gov (United States)

    Muslim, Supari; Suprianto, Bambang; Putra Gitama, Nahindi

    2018-04-01

    Module as a media of learning and training, which especially the students studying in institutions offering education at undergraduate and associate levels can employ as a PLC (Programmable Logic Controller) controlled simulator of the logic gate, timer and counter. During industrial manufacturing processes, has been actualized through this work, for the purpose of training qualified technical personnel needed by companies, who are specialized in control and electro mechanics. It was found that, students are very happy learning to use the module so with very significant contributes to a large extent to the training process in favor of faculty members, who are to train personnel for the sector, and in favor of students, who should be able to acquire proper education. Working on the training tool allows students to acquire knowledge and practical skills and then make use of those skills for troubleshooting and control of machinery.

  20. Development of a head and neck companion module for the quality of life-radiation therapy instrument (QOL-RTI)

    International Nuclear Information System (INIS)

    Trotti, Andy; Johnson, Darlene J.; Gwede, Clement; Casey, Linda; Sauder, Bonnie; Cantor, Alan; Pearlman, James

    1998-01-01

    Purpose/Objective: A review of available head and neck quality of life (QOL) instruments reveals them to inadequately address important radiation related side effects, or to be too cumbersome for routine use. The purpose of this study was to develop a head and neck disease specific module as a companion to the previously developed quality of life - radiation therapy instrument (QOL-RTI). The goal was to create a more complete, yet concise, head and neck site-specific module geared toward patients receiving radiation therapy for head and neck cancer. Methods and Materials: This exploratory study included 34 consecutive patients undergoing definitive radiotherapy over a 6-7 week course (60-79.8 Gy). We developed and administered a 14-item questionnaire to all eligible patients treated with radiotherapy for head and neck cancer who were not already registered in another research study assessing quality of life (e.g., RTOG). During the treatment period, the QOL-RTI general tool and the head and neck (H and N) module were administered as follows: at baseline, at week four (for test-retest), and at the end of the treatment period. For validation purposes the QOL-RTI/H and N was compared to the functional assessment cancer tool head and neck (FACT-H and N) questionnaire. The FACT-H and N was administered one time at week 4, on the same day as the QOL-RTI/H and N. This report includes the treatment phase of the study (during the course of radiation). Results: Mean age was 62 years (range 40-75). Internal consistency of the module was satisfactory (Chronbach's α = 0.85). Test-retest yielded a correlation coefficient of 0.90 (p < 0.001). Concurrent validity, established by comparing the module to the FACT/H and N , yielded a correlation coefficient of 0.85. Significant changes in quality of life scores during a course of radiation was noted for both general quality of life tool and the site specific module. For the head and neck module, the difference in the mean baseline

  1. Cannabinoids as modulators of cancer cell viability, neuronal differentiation, and embryonal development

    OpenAIRE

    Gustafsson, Sofia

    2012-01-01

    Cannabinoids (CBs) are compounds that activate the CB1 and CB2 receptors. CB receptors mediate many different physiological functions, and cannabinoids have been reported to decrease tumor cell viability, proliferation, migration, as well as to modulate metastasis. In this thesis, the effects of cannabinoids on human colorectal carcinoma Caco-2 cells (Paper I) and mouse P19 embryonal carcinoma (EC) cells (Paper III) were studied.  In both cell lines, the compounds examined produced a concentr...

  2. Development of the MCM-D technique for pixel detector modules

    CERN Document Server

    Grah, Christian

    2005-01-01

    This thesis treats a copper--polymer based thin film technology, the MCM-D technique and its application when building hybrid pixel detector modules. The ATLAS experiment at the LHC will be equipped with a pixel detector system. The basic mechanical units of the pixel detector are multi chip modules. The main components of these modules are: 16 electronic chips, a controller chip and a large sensor tile, featuring more than 46000 sensor cells. MCM-D is a superior technique to build the necessary signal bus system and the power distribution system directly on the active sensor tile. In collaboration with the Fraunhofer Institute for Reliability and Microintegration, IZM, the thin film process is reviewed and enhanced. The multi layer system was designed and optimized for the interconnection system as well as for the 46000 pixel contacts. Laboratory measurements on prototypes prove that complex routing schemes for geometrically optimized single chips are suitable and have negligible influence on the front--end ...

  3. Analyzing Thermal Module Developments and Trends in High-Power LED

    Directory of Open Access Journals (Sweden)

    Jung-Chang Wang

    2014-01-01

    Full Text Available The solid-state light emitting diode (SSLED has been verified as consumer-electronic products and attracts attention to indoor and outdoor lighting lamp, which has a great benefit in saving energy and environmental protection. However, LED junction temperature will influence the luminous efficiency, spectral color, life cycle, and stability. This study utilizes thermal performance experiments with the illumination-analysis method and window program (vapour chamber thermal module, VCTM V1.0 to investigate and analyze the high-power LED (Hi-LED lighting thermal module, in order to achieve the best solution of the fin parameters under the natural convection. The computing core of the VCTM program employs the theoretical thermal resistance analytical approach with iterative convergence stated in this study to obtain a numerical solution. Results showed that the best geometry of thermal module is 4.4 mm fin thickness, 9.4 mm fin pitch, and 37 mm fin height with the LED junction temperature of 58.8°C. And the experimental thermal resistances are in good agreement with the theoretical thermal resistances; calculating error between measured data and simulation results is no more than ±7%. Thus, the Hi-LED illumination lamp has high life cycle and reliability.

  4. Modules and Front-End Electronics Developments for the ATLAS ITk Strips Upgrade

    CERN Document Server

    Garcia-Argos, Carlos; The ATLAS collaboration

    2017-01-01

    The ATLAS experiment is currently preparing for an upgrade of the tracking system in the course of the High Luminosity LHC, scheduled for 2024. The existing Inner Detector will be replaced by an all-silicon Inner Tracker (ITk) with a pixel detector surrounded by a strip detector. The ITk strip detector consists of a four layer barrel and a forward region composed of six discs on each side of the barrel. The basic unit of the detector is the silicon-strip module, consisting of a sensor and one or more hybrid circuits that hold the read-out electronics. The geometries of the barrel and end-cap modules take into account the regions that they have to cover. In the central region, the detectors are rectangular with straight strips, whereas on the forward region the modules require wedge shaped sensors with varying strip length and pitch. The current prototyping phase has resulted in the ITk Strip Detector Technical Design Report (TDR), which kicks-off the pre-production readiness phase at the involved institutes. ...

  5. Modules and Front-End Electronics Developments for the ATLAS ITk Strips Upgrade

    CERN Document Server

    Garcia-Argos, Carlos; The ATLAS collaboration

    2017-01-01

    The ATLAS experiment is currently preparing for an upgrade of the tracking system in the course of the High Luminosity LHC, scheduled for 2024. The existing Inner Detector will be replaced by an all-silicon Inner Tracker (ITk) with a pixel detector surrounded by a strip detector. The ITk strip detector consists of a four layer barrel and a forward region composed of six discs on each side of the barrel. The basic unit of the detector is the silicon-strip module, consisting of a sensor and one or more hybrid circuits that hold the read-out electronics. The geometries of the barrel and end-cap modules take into account the regions that they have to cover. In the central region, the detectors are rectangular with straight strips, whereas in the forward region the modules require wedge shaped sensors with varying strip length and pitch. The current prototyping phase has resulted in the ITk Strip Detector Technical Design Report (TDR), which kicks-off the pre-production readiness phase at the involved institutes. ...

  6. Modulators of inhibitor of growth (ING) family expression in development and disease.

    Science.gov (United States)

    Maher, Stacey K; Helbing, Caren C

    2009-05-01

    The inhibitor of growth (ING) gene family proteins regulate many critical cellular processes such as cell proliferation and growth, apoptosis, DNA repair, senescence, angiogenesis, and drug resistance. Their transcripts and proteins are differentially expressed in health and disease and there is evidence for developmental regulation. The vast majority of studies have characterized ING levels in the context of cancer. However, relatively little attention has been paid to the expression of ING family members in other contexts. This review summarizes the findings from human and animal model systems that provide insight into the factors influencing the expression of these important proteins. We examine the influence of cell cycle and aging as well as genotoxic stress on ING expression levels and evaluate several emerging areas of inquiry demonstrating that ING gene activity may be modulated by factors such as the p53 tumor suppressor, DNA methylation, and ING proteins themselves with external factors such as hormones, reactive oxygen species, TGFbeta signalling, and other proteins of pathological significance also influencing ING levels. We then briefly discuss the influence of post-translational modification and changes in subcellular localization as it pertains to modulation of ING expression. Understanding how ING expression is modulated represents a vital aspect of effective drug targeting strategies.

  7. Development and evaluation of a time-dependent radiographic technology by using a muon read out module

    Science.gov (United States)

    Kusagaya, T.; Uchida, T.; Tanaka, H. K. M.; Tanaka, M.

    2012-04-01

    We will present a real-time monitoring system for cosmic-ray muon radiography as an application of a readout module developed by T. Uchida et al [1,2]. The readout module was developed originally for probing the internal structure of volcanoes in 2008 [3]. Its features are small in size, low power consumption, and the capability to access remotely via Ethernet. The current statistics data of cosmic-ray muons can be read from a PC placed far from the module at anytime. By using this feature, we constructed a real-time monitoring system. As a test experiment, we observed fluid movement in a cylinder with a diameter of 112 meters water equivalent. In this work, we succeeded to resolve the fluid movement in the cylinder. We varied the fluid level inside the cylinder and measured the muon intensity. We found that the muon intensity correlates inversely with the fluid level: the muon intensity increases for the lower fluid level and decreases for the higher fluid level. Although the time resolution of muon radiography was sufficient to resolve changes in the fluid level, an adequate time window has to be chosen for different operating conditions. We anticipate that this system will be applicable to exploring high-speed phenomena in a gigantic object.

  8. Structural modulation of brain development by oxygen: evidence on adolescents migrating from high altitude to sea level environment.

    Science.gov (United States)

    Zhang, Jiaxing; Zhang, Haiyan; Chen, Ji; Fan, Ming; Gong, Qiyong

    2013-01-01

    The present study aimed to investigate structural modulation of brain by high level of oxygen during its peak period of development. Voxel-based morphometry analysis of gray matter (GM) and white matter (WM) volumes and Tract-Based Spatial Statistics analysis of WM fractional anisotropy (FA) and mean diffusion (MD) based on MRI images were carried out on 21 Tibetan adolencents (15-18 years), who were born and raised in Qinghai-Tibetan Plateau (2900-4700 m) and have lived at sea level (SL) in the last 4 years. The control group consisted of matched Tibetan adolescents born and raised at high altitude all the time. SL immigrants had increased GM volume in the left insula, left inferior parietal gyrus, and right superior parietal gyrus and decreased GM in the left precentral cortex and multiple sites in cerebellar cortex (left lobule 8, bilateral lobule 6 and crus 1/2). Decreased WM volume was found in the right superior frontal gyrus in SL immigrants. SL immigrants had higher FA and lower MD at multiple sites of WM tracts. Moreover, we detected changes in ventilation and circulation. GM volume in cerebellum lobule 8 positively correlated with diastolic pressure, while GM volume in insula positively correlated vital capacity and hypoxic ventilatory response. Our finding indicate that the structural modulations of GM by high level of oxygen during its peak period of development are related to respiratory and circulatory regulations, while the modulation in WM mainly exhibits an enhancement in myelin maturation.

  9. Development of Nanofiller-Modulated Polymeric Oxygen Enrichment Membranes for Reduction of Nitrogen Oxides in Coal Combustion

    Energy Technology Data Exchange (ETDEWEB)

    Jianzhong Lou; Shamsuddin Ilias

    2010-12-31

    North Carolina A&T State University in Greensboro, North Carolina, has undertaken this project to develop the knowledge and the material to improve the oxygen-enrichment polymer membrane, in order to provide high-grade oxygen-enriched streams for coal combustion and gasification applications. Both experimental and theoretical approaches were used in this project. The membranes evaluated thus far include single-walled carbon nano-tube, nano-fumed silica polydimethylsiloxane (PDMS), and zeolite-modulated polyimide membranes. To document the nanofiller-modulated polymer, molecular dynamics simulations have been conducted to calculate the theoretical oxygen molecular diffusion coefficient and nitrogen molecular coefficient inside single-walled carbon nano-tube PDMS membranes, in order to predict the effect of the nano-tubes on the gas-separation permeability. The team has performed permeation and diffusion experiments using polymers with nano-silica particles, nano-tubes, and zeolites as fillers; studied the influence of nano-fillers on the self diffusion, free volume, glass transition, oxygen diffusion and solubility, and perm-selectivity of oxygen in polymer membranes; developed molecular models of single-walled carbon nano-tube and nano-fumed silica PDMS membranes, and zeolites-modulated polyimide membranes. This project partially supported three graduate students (two finished degrees and one transferred to other institution). This project has resulted in two journal publications and additional publications will be prepared in the near future.

  10. TeSeR – Technology for Self-Removal – First results of an H2020 Project to develop a Post-Mission-Disposal Module

    DEFF Research Database (Denmark)

    Voigt, p.; Vogt, C.; Schubert, R.

    2017-01-01

    The goal of TeSeR (Technology for Self-Removal) is to take the first step towards the development of a scalable, flexible, cost-efficient, but highly reliable Post-Mission-Disposal (PMD) module. This module is to be attached to the spacecraft (S/C) on ground and it shall ensure the PMD of the S/C...

  11. Development of New Low-Cost, High-Performance, PV Module Encapsulant/Packaging Materials: Final Technical Progress Report, 22 October 2002 - 15 November 2007

    Energy Technology Data Exchange (ETDEWEB)

    Tucker, R.

    2008-04-01

    Report on objectives to work with U.S.-based PV module manufacturers (c-Si, a-Si, CIS, other thin films) to develop/qualify new low-cost, high-performance PV module encapsulant/packaging materials, and processes using the packaging materials.

  12. Development of Automated Production Line Processes for Solar Brightfield Modules: Final Annual Technical Progress Report, 1 July 2004 -- 15 October 2005

    Energy Technology Data Exchange (ETDEWEB)

    Nowlan, M. J.; Murach, J. M.; Sutherland, S. F.; Miller, D. C.; Moore S. B.; Hogan, S. J.

    2006-08-01

    Spire Corporation is addressing the Photovoltaic Manufacturing R&D project goals of improving photovoltaic (PV) manufacturing processes and products while reducing costs and providing a technology foundation that supports significant manufacturing scale-up. To accomplish this, we are focusing our efforts on the design of a large-area utility-scale module and the development of the necessary manufacturing techniques and equipment to manufacture such a module in a high-volume production environment. A three-phase program is under way for developing and demonstrating new automated systems for fabricating very large PV modules ideal for use in multi-megawatt grid-connected applications. We designed a large-area (1.57 m x 3.68 m) 800-W module, and we are developing associated module production equipment that will minimize the total installed system cost for utility-scale PV arrays. Activities in Phase 2 focused on the development of automation for module materials lay-up, cell string busing, and module lamination; enhancements to the cell stringing and lamination processes; and performance testing of large-area modules.

  13. Development and pilot testing of an online module for ethics education based on the Nigerian National Code for Health Research Ethics.

    Science.gov (United States)

    Ogunrin, Olubunmi A; Ogundiran, Temidayo O; Adebamowo, Clement

    2013-01-02

    The formulation and implementation of national ethical regulations to protect research participants is fundamental to ethical conduct of research. Ethics education and capacity are inadequate in developing African countries. This study was designed to develop a module for online training in research ethics based on the Nigerian National Code of Health Research Ethics and assess its ease of use and reliability among biomedical researchers in Nigeria. This was a three-phased evaluation study. Phase one involved development of an online training module based on the Nigerian Code of Health Research Ethics (NCHRE) and uploading it to the Collaborative Institutional Training Initiative (CITI) website while the second phase entailed the evaluation of the module for comprehensibility, readability and ease of use by 45 Nigerian biomedical researchers. The third phase involved modification and re-evaluation of the module by 30 Nigerian biomedical researchers and determination of test-retest reliability of the module using Cronbach's alpha. The online module was easily accessible and comprehensible to 95% of study participants. There were significant differences in the pretest and posttest scores of study participants during the evaluation of the online module (p = 0.001) with correlation coefficients of 0.9 and 0.8 for the pretest and posttest scores respectively. The module also demonstrated excellent test-retest reliability and internal consistency as shown by Cronbach's alpha coefficients of 0.92 and 0.84 for the pretest and posttest respectively. The module based on the Nigerian Code was developed, tested and made available online as a valuable tool for training in cultural and societal relevant ethical principles to orient national and international biomedical researchers working in Nigeria. It would complement other general research ethics and Good Clinical Practice modules. Participants suggested that awareness of the online module should be increased through seminars

  14. Development and qualification of functional materials for the EU Test Blanket Modules: Strategy and R and D activities

    Energy Technology Data Exchange (ETDEWEB)

    Zmitko, M., E-mail: milan.zmitko@f4e.europa.eu [Fusion for Energy (F4E), 08019 Barcelona (Spain); Poitevin, Y. [Fusion for Energy (F4E), 08019 Barcelona (Spain); Boccaccini, L., E-mail: lorenzo.boccaccini@inr.fzk.de [Institut Fuer Neutronenphysik und Reaktortechnik, FZK, D-76021 Karlsruhe (Germany); Salavy, J.-F., E-mail: jfsalavy@cea.fr [CEA/Saclay, DEN/DM2S, F-91191 Gif-sur-Yvette (France); Knitter, R., E-mail: regina.knitter@imf.fzk.de [Institut Fuer Materialforschung III, FZK, D-76021 Karlsruhe (Germany); Moeslang, A., E-mail: anton.moeslang@imf.fzk.de [Institut Fuer Materialforschung I, FZK, D-76021 Karlsruhe (Germany); Magielsen, A.J., E-mail: magielsen@nrg.eu [NRG Petten, 1755 ZG Petten (Netherlands); Hegeman, J.B.J. [NRG Petten, 1755 ZG Petten (Netherlands); Laesser, R. [Fusion for Energy (F4E), 08019 Barcelona (Spain)

    2011-10-01

    Europe has developed two reference tritium breeder blankets concepts for a DEMO fusion reactor: the Helium-Cooled Lithium-Lead and the Helium-Cooled Pebble-Bed. Both will be tested in ITER under the form of Test Blanket Modules (TBMs). The paper reviews the current status of development and qualification of the EU TBMs functional materials; i.e. ceramic solid breeder materials, beryllium/beryllides multiplier materials and Lithium-Lead liquid metal breeder material Pb-15.7Li. For each functional material the main functional/performance requirements with key qualification issues, current status of the R and D activities and the EU development strategy are presented. In the development strategy major steps considered are listed pointing out importance of the 'Development/qualification/procurement plan', currently under elaboration, for definition of a roadmap of further activities aiming at delivery of qualified functional materials to be used in the European TBMs in ITER.

  15. Development of a new compound method to extract the five parameters of PV modules

    International Nuclear Information System (INIS)

    Bai, Jianbo; Liu, Sheng; Hao, Yuzhe; Zhang, Zhen; Jiang, Meng; Zhang, Yu

    2014-01-01

    Highlights: • A compound method to extract the five parameters of the five-parameter PV model. • A piecewise curve-fitting method to obtain the differential values at the short and open circuit points. • Simulated and experimental I–V and P–V curves at any operating conditions have excellent agreement. • Prediction of generation output for a PV power station has high accuracy. - Abstract: The five-parameter photovoltaic (PV) mathematical model has been considered a reliable and accurate method for simulating the performance of PV modules. This paper puts forth a new compound method to extract the five parameters of the model with the basic manufacture template data. As the two differential values at the short and open circuit points of the I–V curve at standard testing conditions (STC) are fundamental data to obtain the five parameters and not normally available from the template data, we use a piecewise I–V curve-fitting method combined with the four-parameter PV model to calculate them with which an explicit extraction method is then presented to extract the five parameters at STC conditions by using five individual algebraic equations. Furthermore, the five parameters are revised according to certain operating conditions. In order to evaluate the effectiveness of the proposed method, the simulated I–V characteristic curves for three types of PV modules over a range of operating conditions are compared with the measured data. The experimental results demonstrate that the method has high accuracy. This method is also used to predict the generation power of an actual PV power station; the simulation results show good agreement with the field data. This proposed method is easy to carry out and especially useful for simulating the actual performances of PV modules or arrays at various operating conditions and predicting the output power of real PV power stations

  16. Development of Instrumentation for Spin-Echo Induced Spatial Beam Modulations

    DEFF Research Database (Denmark)

    Sales, Morten

    Spin-Echo Modulated Small Angle Neutron Scattering in Time-of-Flight mode (ToF SEMSANS) is an emerging technique extending the measurable phase space covered by neutron scattering. Using inclined magnetic field surfaces, (very) small angle scattering from a sample can be mapped into the spin...... orientation of the neutron as it has been shown in Spin-Echo Small Angle Neutron Scattering (SESANS). Taking this technique further we have shown that it is possible to perform quantitative Dark-Field Imaging, where the small angle scattering signal of individual areas in a neutron image can be obtained...

  17. Development of high data readout rate pixel module and detector hybridization at Fermilab

    International Nuclear Information System (INIS)

    Zimmermann, Sergio

    2001-01-01

    This paper describes the baseline design and a variation of the pixel module to handle the data rate required for the BTeV experiment at Fermilab. The present prototype has shown good electrical performance characteristics. Indium bump bonding is proven to be capable of successful fabrication at 50 micron pitch on real detectors. For solder bumps at 50 micron pitch, much better results have been obtained with the fluxless PADS processed detectors. The results are adequate for our needs and our tests have validated it as a viable technology

  18. Controlled ecological life support systems: Development of a plant growth module

    Science.gov (United States)

    Averner, Mel M.; Macelroy, Robert D.; Smernoff, David T.

    1987-01-01

    An effort was made to begin defining the scientific and technical requirements for the design and construction of a ground-based plant growth facility. In particular, science design criteria for the Plant Growth Module (PGM) of the Controlled Ecological Life Support System (CELSS) were determined in the following areas: (1) irradiation parameters and associated equipment affecting plant growth; (2) air flow; (3) planting, culture, and harvest techniques; (4) carbon dioxide; (5) temperature and relative humidity; (6) oxygen; (7) construction materials and access; (8) volatile compounds; (9) bacteria, sterilization, and filtration; (10) nutrient application systems; (11) nutrient monitoring; and (12) nutrient pH and conductivity.

  19. Design and development of a data acquisition system for photovoltaic modules characterization

    Energy Technology Data Exchange (ETDEWEB)

    Belmili, Hocine [Unite de Developpement des Equipements Solaires (UDES), Route Nationale No11, Bou-Isamil BP 365, Tipaza 42415, Algerie; Ait Cheikh, Salah Med; Haddadi, Mourad; Larbes, Cherif [Ecole Nationale Polytechnique, Laboratoire de Dispositifs de Communication et de Conversion Photovoltaique (LDCCP), 10 Avenue Hassen Badi, El Harrach 16200 Alger (Algeria)

    2010-07-15

    Testing photovoltaic generators performance is complicated. This is due to the influence of a variety of interactive parameters related to the environment such as solar irradiation and temperature in addition to solar cell material (mono-crystalline, poly-crystalline, amorphous and thin films). This paper presents a computer-based instrumentation system for the characterization of the photovoltaic (PV) conversion. It based on a design of a data acquisition system (DAQS) allowing the acquisition and the drawing of the characterization measure of PV modules in real meteorological test conditions. (author)

  20. Development of sine/cosine coil based on cross-section modulation

    International Nuclear Information System (INIS)

    Harada, Takahiro; Kondoh, Junji; Tsuji-Iio, Shunji; Shimada, Ryuichi

    1996-01-01

    New type sine and cosine coils whose areas of cross sections vary as sine and cosine are proposed. The measurements of current position by the new coils showed their availability. Traditional sine or cosine coil is wound with a pitch which varies as sine or cosine. However these coils have a problem of manufacturing, i.e. it is not easy to wind wire exactly with a pitch of sine or cosine. This new modulation, i.e. varying cross section, provides handy and accurate measurements of the current position. (author)

  1. An online module series to prepare pharmacists to facilitate student engagement in patient-centered care delivery: development and evaluation

    Directory of Open Access Journals (Sweden)

    Kassam R

    2012-06-01

    Full Text Available Rosemin Kassam,1 Mona Kwong,1 John B Collins21Faculty of Pharmaceutical Sciences, 2Department of Educational Studies, University of British Columbia, Vancouver, CanadaIntroduction: Accreditation bodies across North America have adopted revised standards that place increased emphasis on experiential education and preceptors to promote and demonstrate patient-centered, pharmaceutical care practices to students. Since such practices are still evolving, challenges exist in recruiting skilled preceptors who are prepared to provide such opportunities. An online educational module series titled "A Guide to Pharmaceutical Care" (The Guide was developed and evaluated to facilitate this transition. The objectives of this paper are: (1 to describe the development of the modules; and (2 to present the evaluation results from its pilot testing.Methods: The Guide was developed as an online, self-directed training program. It begins by providing an overview of patient care (PC philosophy and practice, and then discusses the tools that facilitate PC. It also provides a range of tips to support students as they provide PC during their experiential learning. Pharmacists participating in the pilot study were recruited using purposive and snowball sampling techniques. A pre–post quantitative survey with additional open-ended questions was used to evaluate the modules.Results: The modules incorporated a variety of teaching strategies: self-reflection exercises, quizzes to review important concepts, quick tips, flash cards, and video clips to illustrate more in-depth learning. Thirty-two pharmacists completed the pre–post assessment and reported significant increases in their confidence because of this training. The most influenced outcome was "Application of techniques to facilitate learning opportunities that enable pharmacy students to practice pharmaceutical care competencies." They also indicated that the training clarified necessary changes in their

  2. Development Of Electronic Digestive System Module For Effective Teaching And Learning

    Directory of Open Access Journals (Sweden)

    Liman Aminu Doko

    2017-07-01

    Full Text Available The digestive system hence digestion of food is usually one of the topics taught at the secondary and tertiary levels of education. Often this topic is taught using teaching aid in the form of diagrams or charts drawn on plane papers. The inanimate nature of these teaching aid employed makes learning less interesting and comprehension difficult. This paper presents the design and construction of a semi animated digestive module with remote control that visualizes the movement and process of food digestion in the body. Basically the system consists of carved wooden digestive organs with light emitting diodes LEDs carefully fixed on the path of digestion. A remote control is also built to aid remote access to the module. These LEDs start to blink indicating swallowing from the mouth down to the anus illustrating the process of digestion which also involves the production of enzymes. A comparison of with the improved teaching aid will make conventional types showed that it aroused student interest during teaching and learning process. It also reduced too much abstract explanation. Thus making teaching more efficient.

  3. Development of a hemispherical rotational modulation collimator system for imaging spatial distribution of radiation sources

    Science.gov (United States)

    Na, M.; Lee, S.; Kim, G.; Kim, H. S.; Rho, J.; Ok, J. G.

    2017-12-01

    Detecting and mapping the spatial distribution of radioactive materials is of great importance for environmental and security issues. We design and present a novel hemispherical rotational modulation collimator (H-RMC) system which can visualize the location of the radiation source by collecting signals from incident rays that go through collimator masks. The H-RMC system comprises a servo motor-controlled rotating module and a hollow heavy-metallic hemisphere with slits/slats equally spaced with the same angle subtended from the main axis. In addition, we also designed an auxiliary instrument to test the imaging performance of the H-RMC system, comprising a high-precision x- and y-axis staging station on which one can mount radiation sources of various shapes. We fabricated the H-RMC system which can be operated in a fully-automated fashion through the computer-based controller, and verify the accuracy and reproducibility of the system by measuring the rotational and linear positions with respect to the programmed values. Our H-RMC system may provide a pivotal tool for spatial radiation imaging with high reliability and accuracy.

  4. Student's Need Analysis for the Development of Chemistry Modules Based Guided Inquiry to Improve Science Process Skill

    Directory of Open Access Journals (Sweden)

    Jane Arantika

    2018-04-01

    Full Text Available Science process skills (SPS are an important aspect of learning science. SPS help students to develop creativity in learning. Process skills such as observing, formulating questions, interpreting, experimenting, hypothesizing, applying concepts, and communicating. This study aims to analyze the need for development resources needs of science filled with science process skills. Requirement analysis of the development of teaching materials with the skill of the process of science needs to be done because the textbook is the reference a teacher in the class. The subjects matter of chemistry the study was three senior high schools in Sambas, West Borneo. Needs analysis conducted using a qualitative approach, in terms of needs in classroom learning and content of process skills on teaching materials. Data were collected by interviews and questionnaires were analyzed descriptively. The results showed that as many as 27 percents of students perceive the book used in learning has not yet trained the science process skills. As many as 73 percents of students perceive that they need instructional materials in the form of inquiry-based chemistry modules to improve science process skills. Modules are developed based guided inquiry for having guided inquiry learning stages that can practice students' science process skills.

  5. Report on achievements in fiscal 1998. Development of technologies to put photovoltaic power generation systems into practical use - Development of solar beam power generation and utilization systems and ancillary technologies (Research and development of building material integrated solar cell modules - high-durability roof modules); 1998 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu seika hokokusho. Taiyoko hatsuden riyo system shuhen gijutsu no kenkyu kaihatsu (shinkenzai ittaigata taiyo denchi module no kenkyu kaihatsu (kotaikyusei yane module))

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    With the target set on a system with a roof array efficiency of 8.5%, and a system cost of 170 yen/W, development is being made on a large roof panel and its construction technology, which is capable of AC output by integrating into a large roof panel the compound thin film solar cells having glass/CdS/CdTe/rear air chamber/rear metal, and the inverter. In the cell constituting materials and the structure design, sealants were evaluated, the painting process was developed, and two kinds of structures were prepared. The frameless type has a lamination structure, and a prototype module of 886 times 664 mm was fabricated, and the frame type has a double sealing structure, and a prototype module 600 times 900 mm was fabricated. Prototype modules that can be fixed on a rail type fixing stand were fabricated and constructed, having demonstrated sufficient workability. In addition, a prototype small inverter with system coordination protection was operated actually, and the initial stage malfunctions were corrected. Two demonstration buildings were built, and the whole process was performed from assembly and transportation of the modules and to the installation thereof at the construction site. (NEDO)

  6. Children's Food and Drink Purchasing Behaviour “Beyond the School Gate”: The Development of a Survey Module

    OpenAIRE

    Wills, Wendy J.; Macdiarmid, Jennie I.; Masson, Lindsey F.; Bromley, Catherine; Craig, Leone; McNeill, Geraldine

    2013-01-01

    Many children eat a diet which supplies a higher than recommended amount of nonmilk extrinsic sugars and saturated fatty acids. The school setting is often targeted for nutrition intervention as many children consume food at school. In Scotland, attempts have been made to improve the nutritional content of food in schools and attention has now turned to food and drink available “beyond the school gate.” This paper describes the development of a module on food and drink purchasing behaviour. T...

  7. Analysis of Factors Influencing the Development of Xerostomia during Intensity-Modulated Radiotherapy

    Science.gov (United States)

    Randall, Ken; Stevens, Jason; Yepes, Juan Fernando; Randall, Marcus E.; Kudrimoti, Mahesh; Feddock, Jonathan; Xi, Jing; Kryscio, Richard J.; Miller, Craig S.

    2013-01-01

    OBJECTIVES Factors influencing xerostomia during intensity-modulated radiation therapy (IMRT) were assessed. METHODS A 6-week study of 32 head and neck cancer (HNC) patients was performed. Subjects completed the Xerostomia Inventory (XI) and provided stimulated saliva (SS) at baseline, week two and at end of IMRT. Influence of SS flow rate (SSFR), calcium and mucin 5b (MUC5b) concentrations and radiation dose on xerostomia was determined. RESULTS HNC subjects experienced mean SSFR decline of 36% by visit two (N=27; p=0.012) and 57% by visit three (N=20; p=0.0004), Concentrations of calcium and MUC5b increased, but not significantly during IMRT (p>0.05). Xerostomia correlated most with decreasing salivary flow rate as determined by Spearman correlations (pxerostomia. PMID:23523462

  8. Development of measurement device for evaluation of solar cell module output. 2; Taiyo denchi module shutsuryoku hyokayo sokuteiki no kaihatsu. 2

    Energy Technology Data Exchange (ETDEWEB)

    Minoda, M.; Itsumi, J. [Kumamoto Institute of Technology, Kumamoto (Japan)

    1996-10-27

    Enhancement in design efficiency may be attained as well as utilization in maintenance if on-the-spot data is made available, for the purpose of flexibly dealing with changes in design or matching with a house structure, in calculating the power generation output of a solar cell (PV) module. Under the circumstances, a small-sized compound measuring device was produced as a prototype which, using an I-V curve tracer, measured output and condition of a roof at the time of installation, compared with the optimum operation and predicted the power generation. The device was structured with the main body consisting of a computing part, measurement controller and power supply and with various sensor modules. The electron load control method was employed in order to measure I-V characteristics of the PV module, since it was desirable to use a variable load and to cover the range from the release voltage of a solar cell to the short-circuit state through the maximum output point. The reference module method was used for the system evaluation. The device was presumably applicable to a PV system design by incorporating a sensor module for measuring design environment data, which was essential at the time of a system design, in addition to those for measuring output. 9 refs., 4 figs., 3 tabs.

  9. Development of Web GIS-Based VFSMOD System with Three Modules for Effective Vegetative Filter Strip Design

    Directory of Open Access Journals (Sweden)

    Dong Soo Kong

    2013-08-01

    Full Text Available In recent years, Non-Point Source Pollution has been rising as a significant environmental issue. The sediment-laden water problem is causing serious impacts on river ecosystems not only in South Korea but also in most countries. The vegetative filter strip (VFS has been thought to be one of the most effective methods to reduce the transport of sediment to down-gradient area. However, the effective width of the VFS first needs to be determined before VFS installation in the field. To provide an easy-to-use interface with a scientific VFS modeling engine, the Web GIS-based VFSMOD system was developed in this study. The Web GIS-based VFSMOD uses the UH and VFSM executable programs from the VFSMOD-w model as core engines to simulate rainfall-runoff and sediment trapping. To provide soil information for a point of interest, the Google Map interface to the MapServer soil database system was developed using the Google Map API, Javascript, Perl/CGI, and Oracle DB programming. Three modules of the Web GIS-based VFSMOD system were developed for various VFS designs under single storm, multiple storm, and long-term period scenarios. These modules in the Web GIS-based VFSMOD system were applied to the study watershed in South Korea and these were proven as efficient tools for the VFS design for various purposes.

  10. Design and development of cell queuing, processing, and scheduling modules for the iPOINT input-buffered ATM testbed

    Science.gov (United States)

    Duan, Haoran

    1997-12-01

    heuristic strategy that leads to 'socially optimal' solutions, yielding a maximum number of contention-free cells being scheduled. A novel mixed digital-analog circuit has been designed to implement the MUCS core functionality. The MUCS circuit maps the cell scheduling computation to the capacitor charging and discharging procedures that are conducted fully in parallel. The design has a uniform circuit structure, low interconnect counts, and low chip I/O counts. Using 2 μm CMOS technology, the design operates on a 100 MHz clock and finds a near-optimal solution within a linear processing time. The circuit has been verified at the transistor level by HSPICE simulation. During this research, a five-port IQ-based optoelectronic iPOINT ATM switch has been developed and demonstrated. It has been fully functional with an aggregate throughput of 800 Mb/s. The second-generation IQ-based switch is currently under development. Equipped with iiQueue modules and MUCS module, the new switch system will deliver a multi-gigabit aggregate throughput, eliminate HOL blocking, provide per-VC QoS, and achieve near-100% link bandwidth utilization. Complete documentation of input modules and trunk module for the existing testbed, and complete documentation of 3DQ, iiQueue, and MUCS for the second-generation testbed are given in this dissertation.

  11. A Learning Module for BA Students to Develop ICT Skills for their Learning Activities | Un module de formation visant le développement des compétences TICE chez les étudiants en baccalauréat

    Directory of Open Access Journals (Sweden)

    Hervé Platteaux

    2015-11-01

    Full Text Available This case illustrates the process of developing a learning module to support BA students in their use of ICT (Information and Communication Technology tools in their learning. At the university where this case occurred, the skill level of ICT use among students in a learning context was very heterogeneous. The E-learning Competency Centre, or ECC, which was in charge of techno-pedagogical development at the institution, created a hybrid learning module that offered students learning materials and activities with both face-to-face workshops and online tutorials for autonomous learning. The students were able to choose subjects they wanted to learn "à la carte" by taking tutorials on their own and/or by participating in face-to-face workshops. The module described in this case is currently under construction. The design phase of this project is the focus of this case study.

  12. Shield fabrication development of ITER primary wall modules by powder HIP. ITER task T216-Subtask 3E1

    International Nuclear Information System (INIS)

    Lind, A.

    1997-12-01

    A research and development program for the blanket shield in the International Thermonuclear Experimental Reactor (ITER) has been implemented to provide input for the design and manufacture of full scale production components. It comprises fabrication and testing of mock-ups and prototype modules. The design, materials, manufacture, examination, testing and inspection of the mock-ups representing future full scale production modules. This work applies to the development of a shield block fabrication method by Hot Isostatic Pressing (HIP) starting from a gas atomised powder and pre-fabricated cooling tube galleries. The size of the block is 1250 x 650 x 250 mm and the weight is about 1400 kg. Examination and testing of the block was performed to determine properties, achieved fabrication tolerances, and quality of bonding. It is concluded that the today's powder HIP route gives a 316 LN IG material with mechanical properties which fulfills the ITER material specification requirements and a fully dense block which is easy to examine with ultrasonic methods. The joints between tubes and matrix are excellent. In order to achieve and maintain accuracy in positioning of the tubes during fabrication improvements of the standard fabrication route have been identified, such as the positioning of tubes during welding, the powder particle distribution and the powder filling procedure. Modification of the actual HIP cycle may also be required

  13. Shield fabrication development of ITER primary wall modules by powder HIP. ITER task T216-Subtask 3E1

    Energy Technology Data Exchange (ETDEWEB)

    Lind, A

    1997-12-01

    A research and development program for the blanket shield in the International Thermonuclear Experimental Reactor (ITER) has been implemented to provide input for the design and manufacture of full scale production components. It comprises fabrication and testing of mock-ups and prototype modules. The design, materials, manufacture, examination, testing and inspection of the mock-ups representing future full scale production modules. This work applies to the development of a shield block fabrication method by Hot Isostatic Pressing (HIP) starting from a gas atomised powder and pre-fabricated cooling tube galleries. The size of the block is 1250 x 650 x 250 mm and the weight is about 1400 kg. Examination and testing of the block was performed to determine properties, achieved fabrication tolerances, and quality of bonding. It is concluded that the today`s powder HIP route gives a 316 LN IG material with mechanical properties which fulfills the ITER material specification requirements and a fully dense block which is easy to examine with ultrasonic methods. The joints between tubes and matrix are excellent. In order to achieve and maintain accuracy in positioning of the tubes during fabrication improvements of the standard fabrication route have been identified, such as the positioning of tubes during welding, the powder particle distribution and the powder filling procedure. Modification of the actual HIP cycle may also be required

  14. Ultra-Wideband Optical Modulation Spectrometer (OMS) Development: Study of the Optical Setup of a Wide-Band Optical Modulation Spectrometer

    Science.gov (United States)

    Tolls, Volker; Stringfellow, Guy (Technical Monitor)

    2001-01-01

    The purpose of this study is to advance the design of the optical setup for a wide-band Optical Modulation Spectrometer (OMS) for use with astronomical heterodyne receiver systems. This report describes the progress of this investigation achieved from March until December 2001.

  15. Development of an SH Wave Magnetostrictive Transducer Module for Guided Wave Testing of Plate Structures

    International Nuclear Information System (INIS)

    Cho, Seung Hyun; Park, Jae Ha; Kwon Hyu Sang; Ahn, Bong Young; Lee, Seung Seok

    2009-01-01

    Recently much attention has been paid to a guided wave due to its effective applicability to long range and fast inspection of structures. In guided wave based NDE, the appropriate selection of wave modes is one of important factors since the test performance is highly dependent on which mode of guided waves is employed. As far as plate-like structures are concerned, so far, SH guided wave has not been frequently applied compared to Lamb waves, which is mostly caused by the lack of proper and convenient transducers to generate and measure the SH waves. In this investigation, a new small-sized SH guided wave transducer based on magnetostriction is proposed. The present transducer was designed to be modular and be used with shear couplant to avoid the inconvenience of the existing magnetostrictive patch transducers, which comprises the ferromagnetic patch tightly bonded to a structure. The wave transduction mechanism and the detailed configuration of the present transducer are presented. Experimental verification is also conducted on test specimens and the results confirm the good performance of the present transducer module

  16. Development of an SH Wave Magnetostrictive Transducer Module for Guided Wave Testing of Plate Structures

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Seung Hyun; Park, Jae Ha; Kwon Hyu Sang; Ahn, Bong Young; Lee, Seung Seok [Korea Research Institute of Standards and Science, Daejeon (Korea, Republic of)

    2009-04-15

    Recently much attention has been paid to a guided wave due to its effective applicability to long range and fast inspection of structures. In guided wave based NDE, the appropriate selection of wave modes is one of important factors since the test performance is highly dependent on which mode of guided waves is employed. As far as plate-like structures are concerned, so far, SH guided wave has not been frequently applied compared to Lamb waves, which is mostly caused by the lack of proper and convenient transducers to generate and measure the SH waves. In this investigation, a new small-sized SH guided wave transducer based on magnetostriction is proposed. The present transducer was designed to be modular and be used with shear couplant to avoid the inconvenience of the existing magnetostrictive patch transducers, which comprises the ferromagnetic patch tightly bonded to a structure. The wave transduction mechanism and the detailed configuration of the present transducer are presented. Experimental verification is also conducted on test specimens and the results confirm the good performance of the present transducer module

  17. The P2X7 ATP receptor modulates renal cyst development in vitro

    International Nuclear Information System (INIS)

    Hillman, Kate A.; Woolf, Adrian S.; Johnson, Tanya M.; Wade, Angela; Unwin, Robert J.; Winyard, Paul J.D.

    2004-01-01

    P2X 7 , a piercing receptor, is expressed in renal collecting ducts as they undergo fulminant cysto genesis in the cpk/cpk mouse model of autosomal recessive polycystic kidney disease (ARPKD). Dissociated cpk/cpk kidneys generate cysts from cell aggregates within 24 h of suspension culture and we demonstrate that BzATP, a P2X 7 agonist, reduces cystogenesis. This effect is P2X 7 -specific, because: (i) equimolar concentrations of other purinergic agonists, ATP and UTP, had lesser effects and (ii) the P2X 7 inhibitor, oxidized ATP, abrogated the BzATP-mediated reduction in cystogenesis. BzATP did not significantly affect total cell number, proliferation, LDH release or caspase 3 activity, and zVAD-fmk, a caspase blocker, failed to modulate BzATP effects. In addition, this P2X 7 agonist did not significantly alter cyst size, probably excluding altered vectorial transport. In vivo, ATP was detected in cyst fluid from cpk/cpk kidneys; moreover, P2X 7 protein was also upregulated in human fetal ARPKD epithelia versus normal fetal collecting ducts. Thus, ATP may inhibit pathological renal cyst growth through P2X 7 signaling

  18. Development of n-in-p pixel modules for the ATLAS Upgrade at HL-LHC

    CERN Document Server

    Macchiolo, Anna; Savic, Natascha; Terzo, Stefano

    2016-09-21

    Thin planar pixel modules are promising candidates to instrument the inner layers of the new ATLAS pixel detector for HL-LHC, thanks to the reduced contribution to the material budget and their high charge collection efficiency after irradiation. 100-200 $\\mu$m thick sensors, interconnected to FE-I4 read-out chips, have been characterized with radioactive sources and beam tests at the CERN-SPS and DESY. The results of these measurements are reported for devices before and after irradiation up to a fluence of $14\\times10^{15}$ n$_{eq}$/cm$^2$. The charge collection and tracking efficiency of the different sensor thicknesses are compared. The outlook for future planar pixel sensor production is discussed, with a focus on sensor design with the pixel pitches (50x50 and 25x100 $\\mu$m$^2$) foreseen for the RD53 Collaboration read-out chip in 65 nm CMOS technology. An optimization of the biasing structures in the pixel cells is required to avoid the hit efficiency loss presently observed in the punch-through region...

  19. Neonatal exposure to daidzein, genistein, or the combination modulates bone development in female CD-1 mice.

    Science.gov (United States)

    Kaludjerovic, Jovana; Ward, Wendy E

    2009-03-01

    Neonatal exposure to genistein (GEN), an isoflavone abundant in soy, favorably modulates bone mineral density (BMD) and bone strength in mice at adulthood. The study objective was to determine whether early exposure to a combination of the soy isoflavones daidzein (DAI) and GEN that naturally exists in soy protein-based infant formula results in greater benefits to bone at adulthood than either treatment alone. Male and female CD-1 mice (n = 8-16 pups per group per gender) were randomized to subcutaneous injections of DAI (2 mg x kg body weight(-1) x d(-1)), GEN (5 mg x kg body weight(-1) x d(-1)), DAI+GEN (7 mg x kg body weight(-1) x d(-1)), diethylstilbesterol (DES; positive control) (2 mg x kg body weight(-1) x d(-1)), or control (CON) from postnatal d 1-5 and were studied to 4 mo of age. BMD, biomechanical bone strength, and bone microarchitecture were assessed at the femur and lumbar vertebrae (LV). Females treated with DAI, GEN, DAI+GEN, or DES had greater (P GEN resulted in greater (P GEN had a positive effect on the skeleton of female mice at adulthood, but, compared with individual treatments, DAI+GEN did not have a greater benefit to bone in females or males.

  20. Lithium blocks ethanol-induced modulation of protein kinases in the developing brain

    International Nuclear Information System (INIS)

    Chakraborty, Goutam; Saito, Mitsuo; Mao, Rui-Fen; Wang, Ray; Vadasz, Csaba; Saito, Mariko

    2008-01-01

    Lithium has been shown to be neuroprotective against various insults including ethanol exposure. We previously reported that ethanol-induced apoptotic neurodegeneration in the postnatal day 7 (P7) mice is associated with decreases in phosphorylation levels of Akt, glycogen synthase kinase-3β (GSK-3β), and AMP-activated protein kinase (AMPK), and alteration in lipid profiles in the brain. Here, P7 mice were injected with ethanol and lithium, and the effects of lithium on ethanol-induced alterations in phosphorylation levels of protein kinases and lipid profiles in the brain were examined. Immunoblot and immunohistochemical analyses showed that lithium significantly blocked ethanol-induced caspase-3 activation and reduction in phosphorylation levels of Akt, GSK-3β, and AMPK. Further, lithium inhibited accumulation of cholesterol ester (ChE) and N-acylphosphatidylethanolamine (NAPE) triggered by ethanol in the brain. These results suggest that Akt, GSK-3β, and AMPK are involved in ethanol-induced neurodegeneration and the neuroprotective effects of lithium by modulating both apoptotic and survival pathways

  1. Efficacy of bioactive compounds from extra virgin olive oil to modulate atherosclerosis development.

    Science.gov (United States)

    Lou-Bonafonte, José M; Arnal, Carmen; Navarro, María A; Osada, Jesús

    2012-07-01

    As olive oil is the main source of calories in the Mediterranean diet, a great deal of research has been devoted to characterizing its role in atherosclerosis. Virgin olive oil is an oily matrix that contains hydrocarbons, mainly squalene; triterpenes such as uvaol, erythrodiol, oleanolic, and maslinic acid; phytosterols; and a wide range of phenolic compounds comprising simple phenols, flavonoids, secoiridoids, and lignans. In this review, we analyze the studies dealing with atherosclerosis and olive oil in several species. A protective role of virgin olive oil against atherosclerosis has been shown in ApoE-deficient mice and hamsters. In the former animal, sex, dose, and dietary cholesterol are modulators of the outcome. Contradictory findings have been reported for rabbits, a circumstance that could be due to the profusion of experimental designs, differing in terms of doses and animal strains, as well as sources of olive oils. This role has yet to be fully validated in humans. Minor components of olive oil have been shown to be involved in atherosclerosis protection. Nevertheless, evidence of the potential of isolated compounds or the right combination of them to achieve the antiatherosclerotic effect of virgin olive oil is inconclusive and will undoubtedly require further experimental support. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Development of PSpice modeling platform for 10 kV/100 A SiC MOSFET power module

    DEFF Research Database (Denmark)

    Martins, Joäo Pedro Rodrigues; Nawaz, Muhammad; Ilves, Kalle

    2017-01-01

    was implemented based on the already established McNutt Hefner model originally developed for discrete single-die based SiC-MOSFETs. The proposed model has been verified both with static and dynamic experimental data and at different temperatures. Moreover, the energy loss assessment has been performed...... for a variety of operating parameters (e.g., stray inductance, gate resistance), different load current and supply voltages. The model was also verified with parallel connection of several power modules in order to predict the current unbalance as a result of various parasitic elements in the test circuit....... The developed model has been further extended to study the electro-thermal behaviour under short circuit with accurate predictability, and validated with the experimental data. Finally, the operational robustness of the model was judged by simulating an arbitrary Buck, and Boost converter where the converter...

  3. Modulating the profit motive to meet needs of the less-developed world.

    Science.gov (United States)

    Schieppati, A; Remuzzi, G; Garattini, S

    2001-11-10

    The success, despite the problems, of academic/industrial collaborations over the past decade owes much to the profit motive. However, market-driven research and development has little to offer patients in the less-developed world. Some flexibility has already been demonstrated on drugs for orphan (rare or under-researched) diseases. Many diseases in less-developed countries are not rare. Academic researchers should be encouraging the establishment of funding for basic and clinical research that is directed at patients' needs in the less-developed world and that is independent of a commercial ethos.

  4. Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase

    Directory of Open Access Journals (Sweden)

    Stefanou Nikolaos

    2010-08-01

    Full Text Available Abstract Background Numerous epidemiological studies have documented that obesity is associated with hepatocellular carcinoma (HCC. The aim of this study was to investigate the biological actions regulated by leptin, the obesity biomarker molecule, and its receptors in HCC and the correlation between leptin and human telomerase reverse transcriptase (hTERT, a known mediator of cellular immortalization. Methods We investigated the relationship between leptin, leptin receptors and hTERT mRNA expression in HCC and healthy liver tissue samples. In HepG2 cells, chromatin immunoprecipitation assay was used to study signal transducer and activator of transcription-3 (STAT3 and myc/mad/max transcription factors downstream of leptin which could be responsible for hTERT regulation. Flow cytometry was used for evaluation of cell cycle modifications and MMP1, 9 and 13 expression after treatment of HepG2 cells with leptin. Blocking of leptin's expression was achieved using siRNA against leptin and transfection with liposomes. Results We showed, for the first time, that leptin's expression is highly correlated with hTERT expression levels in HCC liver tissues. We also demonstrated in HepG2 cells that leptin-induced up-regulation of hTERT and TA was mediated through binding of STAT3 and Myc/Max/Mad network proteins on hTERT promoter. We also found that leptin could affect hepatocellular carcinoma progression and invasion through its interaction with cytokines and matrix mettaloproteinases (MMPs in the tumorigenic microenvironment. Furthermore, we showed that histone modification contributes to leptin's gene regulation in HCC. Conclusions We propose that leptin is a key regulator of the malignant properties of hepatocellular carcinoma cells through modulation of hTERT, a critical player of oncogenesis.

  5. Development of n-in-p pixel modules for the ATLAS upgrade at HL-LHC

    Science.gov (United States)

    Macchiolo, A.; Nisius, R.; Savic, N.; Terzo, S.

    2016-09-01

    Thin planar pixel modules are promising candidates to instrument the inner layers of the new ATLAS pixel detector for HL-LHC, thanks to the reduced contribution to the material budget and their high charge collection efficiency after irradiation. 100-200 μm thick sensors, interconnected to FE-I4 read-out chips, have been characterized with radioactive sources and beam tests at the CERN-SPS and DESY. The results of these measurements are reported for devices before and after irradiation up to a fluence of 14 ×1015 neq /cm2 . The charge collection and tracking efficiency of the different sensor thicknesses are compared. The outlook for future planar pixel sensor production is discussed, with a focus on sensor design with the pixel pitches (50×50 and 25×100 μm2) foreseen for the RD53 Collaboration read-out chip in 65 nm CMOS technology. An optimization of the biasing structures in the pixel cells is required to avoid the hit efficiency loss presently observed in the punch-through region after irradiation. For this purpose the performance of different layouts have been compared in FE-I4 compatible sensors at various fluence levels by using beam test data. Highly segmented sensors will represent a challenge for the tracking in the forward region of the pixel system at HL-LHC. In order to reproduce the performance of 50×50 μm2 pixels at high pseudo-rapidity values, FE-I4 compatible planar pixel sensors have been studied before and after irradiation in beam tests at high incidence angle (80°) with respect to the short pixel direction. Results on cluster shapes, charge collection and hit efficiency will be shown.

  6. ESD practice through global approach -7-year practices of developing science lessen modules and fostering integrated decision making ability-

    Science.gov (United States)

    Kajiyama, Kosei

    2016-04-01

    Hiroshima University High School (HUHS) has devised and carried out overseas exchange programs on ESD issues for 7 years. These programs have been carried out as a part of a government-aided project called SSH (Super Science High School) *1. To start with, we had cooperative study program with a school in Germany in 2009, and next year with a school in Korea, and then gradually have expanded the cooperative schools. Since 2013, we have worked with schools in four countries; Korea, Thailand, Czech and Germany. Science lesson modules here refers to an assembly of a set of lessons, newly developed and improved for the project. These modules characteristically require the students to make decisions by themselves on given problems. In the course of the decision making, students learn what kind of data or facts should be presented as evidence and how they can make their decisions known to others. Among several modules we have designed, the one introduced here deals with the use of solar energy, which we carried out with a school in Korea in 2014-2015. It also includes lessons of the fuel cells using energy from hydrogen gas generated by solar cells. It aims to develop global human resources through carefully planned activities. First, the students of both schools make mixed groups and conduct experiments in physics, chemistry or biology on a given problem related to solar energy. Then they discuss in groups using data obtained from the experiments and through the Internet as evidence. After the thorough discussion, each group gives a presentation on their decision. The analysis of the presentations and the questionnaire to the students revealed the following points: 1) Students have come to have multidimensional perspectives on the utilization of solar energy. 2) Students have come to combine the results of different experiments when making decisions. 3) Students have developed flexible attitudes toward other cultures. 4) Students have developed communication skills in

  7. Design and Development of a Geography Module for First-year Primary Student Teachers

    NARCIS (Netherlands)

    Blankman, M.; van der Schee, J.; Boogaard, M.; Volman, M.

    2016-01-01

    This paper describes the result of a design study in which a geography course was developed and tested aiming to develop the Pedagogical Content Knowledge (PCK) of first-year primary student teachers. This resulted in a course called ‘Consciously Teaching Geography’ with characteristics as (1)

  8. Design and Development of a Geography Module for First-Year Primary Student Teachers

    Science.gov (United States)

    Blankman, Marian; van der Schee, Joop; Boogaard, Marianne; Volman, Monique

    2016-01-01

    This paper describes the result of a design study in which a geography course was developed and tested aiming to develop the Pedagogical Content Knowledge (PCK) of first-year primary student teachers. This resulted in a course called "Consciously Teaching Geography" with characteristics as (1) starting from students' preconceptions and…

  9. Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma.

    Directory of Open Access Journals (Sweden)

    Rebecca King

    2018-01-01

    Full Text Available Central corneal thickness (CCT is one of the most heritable ocular traits and it is also a phenotypic risk factor for primary open angle glaucoma (POAG. The present study uses the BXD Recombinant Inbred (RI strains to identify novel quantitative trait loci (QTLs modulating CCT in the mouse with the potential of identifying a molecular link between CCT and risk of developing POAG. The BXD RI strain set was used to define mammalian genomic loci modulating CCT, with a total of 818 corneas measured from 61 BXD RI strains (between 60-100 days of age. The mice were anesthetized and the eyes were positioned in front of the lens of the Phoenix Micron IV Image-Guided OCT system or the Bioptigen OCT system. CCT data for each strain was averaged and used to QTLs modulating this phenotype using the bioinformatics tools on GeneNetwork (www.genenetwork.org. The candidate genes and genomic loci identified in the mouse were then directly compared with the summary data from a human POAG genome wide association study (NEIGHBORHOOD to determine if any genomic elements modulating mouse CCT are also risk factors for POAG.This analysis revealed one significant QTL on Chr 13 and a suggestive QTL on Chr 7. The significant locus on Chr 13 (13 to 19 Mb was examined further to define candidate genes modulating this eye phenotype. For the Chr 13 QTL in the mouse, only one gene in the region (Pou6f2 contained nonsynonymous SNPs. Of these five nonsynonymous SNPs in Pou6f2, two resulted in changes in the amino acid proline which could result in altered secondary structure affecting protein function. The 7 Mb region under the mouse Chr 13 peak distributes over 2 chromosomes in the human: Chr 1 and Chr 7. These genomic loci were examined in the NEIGHBORHOOD database to determine if they are potential risk factors for human glaucoma identified using meta-data from human GWAS. The top 50 hits all resided within one gene (POU6F2, with the highest significance level of p = 10-6 for

  10. Design development and manufacturing sequence of the European water-cooled Pb-17Li test blanket module

    Energy Technology Data Exchange (ETDEWEB)

    Futterer, M.A.; Bielak, B.; Deffain, J.P.; Giancarli, L.; Li Puma, A.; Salavy, J.F.; Szczepanski, J. [CEA Saclay, Gif-sur-Yvette (France). FDRN/DMT/SERMA; Dellis, C. [CEA Grenoble, DTA-CEREM/SGM, Grenoble (France); Nardi, C. [ENEA Frascati, ERG-FUS-TECN-MEC, Frascati (Italy); Schleisiek, K. [Forschungszentrum Karlsruhe GmbH Technik und Umwelt (Germany). Inst. fuer Reaktorsicherheit

    1998-09-01

    In 1996, the European Community started the development of a water-cooled Pb17Li blanket test module for ITER. First tests are currently scheduled to start with the beginning of the basic performance phase prior to D-T operation. The test module is designed to be a representative for a DEMO breeding blanket and relies on the liquid alloy Pb-17Li as both tritium breeder and neutron multiplier material, and water at PWR pressure and temperature as coolant. The structural material is martensitic steel. The straight, box-like structure of this blanket confines a pool of liquid Pb-17Li which is slowly circulated for ex-situ tritium extraction and lithium adjustment. The box and the Pb-17Li pool are separately cooled, the former with toroido-radial tubes, the latter with a bundle of double-walled U-tubes, equally made of martensitic steel and equipped with a permeation barrier. This paper presents the latest design and three manufacturing schemes with different degrees of technology. Advanced techniques such as solid or powder HIP are proposed to provide design flexibility. With a 3D neutronics analysis, the power and tritium generation were determined. (orig.) 11 refs.

  11. An integrated framework to address climate change (ESCAPE) and further developments of the global and regional climate modules (MAGICC)

    International Nuclear Information System (INIS)

    Hulme, M.; Raper, S.C.B.

    1995-01-01

    ESCAPE (the Evaluation of Strategies to address Climate change by Adapting to and Preventing Emissions) is an integrated climate change assessment model constructed between 1990 and 1992 for DG XI of the Commission of the European Community by a consortium of research institutes headed by the Climatic Research Unit (CRU). It has been designed to enable the user to generate future scenarios of greenhouse gas emissions (through an energy-economic model), examine their impact on global climate and sea level (through two independent global climate models), and illustrate some of the consequences of this global climate change at a regional scale for the European Community (through a regional climate scenario generator and impact models). We provide a very brief overview of the ESCAPE model which, although innovative, suffers from a number of major limitations. Subsequent work in the CRU has concentrated on improvements to the global climate module and work has also commenced on an improved regional climate scenario generating module. These improvements will lead to a new integrated climate change assessment model, MAGICC (Model for the Assessment of Greenhouse gas Induced Climate Change) which can easily be incorporated into new larger integrated frameworks developed by other institutes. (Author)

  12. Development of versatile non-homologous end joining-based knock-in module for genome editing.

    Science.gov (United States)

    Sawatsubashi, Shun; Joko, Yudai; Fukumoto, Seiji; Matsumoto, Toshio; Sugano, Shigeo S

    2018-01-12

    CRISPR/Cas9-based genome editing has dramatically accelerated genome engineering. An important aspect of genome engineering is efficient knock-in technology. For improved knock-in efficiency, the non-homologous end joining (NHEJ) repair pathway has been used over the homology-dependent repair pathway, but there remains a need to reduce the complexity of the preparation of donor vectors. We developed the versatile NHEJ-based knock-in module for genome editing (VIKING). Using the consensus sequence of the time-honored pUC vector to cut donor vectors, any vector with a pUC backbone could be used as the donor vector without customization. Conditions required to minimize random integration rates of the donor vector were also investigated. We attempted to isolate null lines of the VDR gene in human HaCaT keratinocytes using knock-in/knock-out with a selection marker cassette, and found 75% of clones isolated were successfully knocked-in. Although HaCaT cells have hypotetraploid genome composition, the results suggest multiple clones have VDR null phenotypes. VIKING modules enabled highly efficient knock-in of any vectors harboring pUC vectors. Users now can insert various existing vectors into an arbitrary locus in the genome. VIKING will contribute to low-cost genome engineering.

  13. Development of a high-resolution detection module for the INSERT SPECT/MRI system

    Energy Technology Data Exchange (ETDEWEB)

    Busca, Paolo; Fiorini, Carlo; Butt, Arslan D; Occhipinti, Michele; Quaglia, Riccardo; Trigilio, Paolo [Politecnico di Milano, Dipartimento di Elettronica, Informazione e Bioingegneria, Via Golgi 40, 20133 Milano (Italy); Istituto Nazionale di Fisica Nucleare, Sezione di Milano, Via Celoria 16, 20133 Milano (Italy); Nemeth, Gabor; Major, Peter; Bukki, Tamas; Nagy, Kalman [Mediso Medical Imaging Systems, Alsotorokvesz 14, H-1022 Budapest (Hungary); Piemonte, Claudio; Ferri, Alessandro; Gola, Alberto [Fondazione Bruno Kessler (FBK), Via Sommarive, 18, 38123 Trento (Italy); Rieger, Jan [MRI.TOOLS GmbH, Robert-Roessle-Str. 10, 13125 Berlin (Germany); Niendorf, Thoralf [MRI.TOOLS GmbH, Robert-Roessle-Str. 10, 13125 Berlin (Germany); Berlin Ultrahigh Field Facility (B.UniversityF.F.), Max-Delbrueck-Center for Molecular Medicine, Berlin (Germany)

    2014-07-29

    A new multi-modality imaging tool is under development in the framework of the INSERT (Integrated SPECT/MRI for Enhanced Stratification in Radio-chemo Therapy) project, supported by the European Community. The final goal is to develop a custom SPECT apparatus that can be used as an insert for commercially available MRI systems. INSERT is expected to offer more effective and earlier diagnosis with potentially better outcome in survival for the treatment of brain tumors, primarily glioma. Two SPECT prototypes are being developed, one dedicated to preclinical imaging (7 and 9.4 T), the second one dedicated to clinical imaging (3 T).

  14. Development of a high-resolution detection module for the INSERT SPECT/MRI system

    International Nuclear Information System (INIS)

    Busca, Paolo; Fiorini, Carlo; Butt, Arslan D; Occhipinti, Michele; Quaglia, Riccardo; Trigilio, Paolo; Nemeth, Gabor; Major, Peter; Bukki, Tamas; Nagy, Kalman; Piemonte, Claudio; Ferri, Alessandro; Gola, Alberto; Rieger, Jan; Niendorf, Thoralf

    2014-01-01

    A new multi-modality imaging tool is under development in the framework of the INSERT (Integrated SPECT/MRI for Enhanced Stratification in Radio-chemo Therapy) project, supported by the European Community. The final goal is to develop a custom SPECT apparatus that can be used as an insert for commercially available MRI systems. INSERT is expected to offer more effective and earlier diagnosis with potentially better outcome in survival for the treatment of brain tumors, primarily glioma. Two SPECT prototypes are being developed, one dedicated to preclinical imaging (7 and 9.4 T), the second one dedicated to clinical imaging (3 T).

  15. Mentale Inzetbaarheid van Teams: Ontwikkeling van een Moden van Teamfunctioneren als Module voor SCOPE (Mental Readiness of Teams - Development of a Team Model as Module for SCOPE)

    Science.gov (United States)

    2007-04-01

    inzetbaarheid van teams: ontwikkeling van een model van teamfunctioneren als module voor SCOPE Datumn april 2007 Auteur (s) R. de B~ruin C’. Vervvijs A.J...Datum april 2007 Programmaleider Projectleider Auteur (s) dr. W.A. Lotens, TNO Defensie en A.]. van Vijet, TNO Defensie en R. de Bruin Veiligheid...Deelnemers verwachten wel, in lijn met de theorie , dat een lage cohesie samenhangt met een lage effectiviteit. Een hoge cohesie, daarentegen, zou

  16. Acetylcholine Modulates the Hormones of the Growth Hormone/Insulinlike Growth Factor-1 Axis During Development in Mice.

    Science.gov (United States)

    Lecomte, Marie-José; Bertolus, Chloé; Ramanantsoa, Nélina; Saurini, Françoise; Callebert, Jacques; Sénamaud-Beaufort, Catherine; Ringot, Maud; Bourgeois, Thomas; Matrot, Boris; Collet, Corinne; Nardelli, Jeannette; Mallet, Jacques; Vodjdani, Guilan; Gallego, Jorge; Launay, Jean-Marie; Berrard, Sylvie

    2018-04-01

    Pituitary growth hormone (GH) and insulinlike growth factor (IGF)-1 are anabolic hormones whose physiological roles are particularly important during development. The activity of the GH/IGF-1 axis is controlled by complex neuroendocrine systems including two hypothalamic neuropeptides, GH-releasing hormone (GHRH) and somatostatin (SRIF), and a gastrointestinal hormone, ghrelin. The neurotransmitter acetylcholine (ACh) is involved in tuning GH secretion, and its GH-stimulatory action has mainly been shown in adults but is not clearly documented during development. ACh, together with these hormones and their receptors, is expressed before birth, and somatotroph cells are already responsive to GHRH, SRIF, and ghrelin. We thus hypothesized that ACh could contribute to the modulation of the main components of the somatotropic axis during development. In this study, we generated a choline acetyltransferase knockout mouse line and showed that heterozygous mice display a transient deficit in ACh from embryonic day 18.5 to postnatal day 10, and they recover normal ACh levels from the second postnatal week. This developmental ACh deficiency had no major impact on weight gain and cardiorespiratory status of newborn mice. Using this mouse model, we found that endogenous ACh levels determined the concentrations of circulating GH and IGF-1 at embryonic and postnatal stages. In particular, serum GH level was correlated with brain ACh content. ACh also modulated the levels of GHRH and SRIF in the hypothalamus and ghrelin in the stomach, and it affected the levels of these hormones in the circulation. This study identifies ACh as a potential regulator of the somatotropic axis during the developmental period.

  17. 78 FR 14103 - Request for Information (RFI) Regarding the Planned Biotechnology Development Module (BDM) as...

    Science.gov (United States)

    2013-03-04

    ... the treatment of animals and act primarily through the direct stimulation, supplementation... timely development of countermeasures in the event of an outbreak. NBAF meets that need and will serve as...

  18. Development of paper-based wireless communication modules for point-of-care diagnostic applications

    CSIR Research Space (South Africa)

    Smith, Suzanne

    2016-09-01

    Full Text Available . Printing of radio frequency identification antennas and electronic circuitry for sensing on paper are presented, with read out of the results using a radio frequency identification reader illustrated, demonstrating the feasibility of developing integrated...

  19. A cooperative inquiry into action learning and praxis development in a community nursing module.

    Science.gov (United States)

    Jenkins, Emrys R; Mabbett, Gaynor M; Surridge, Andrea G; Warring, Joanna; Gwynn, Elizabeth D

    2009-09-01

    As nurse lecturers we investigated practice development and action learning approaches aimed at enabling postregistration bachelor's- and master's-level nursing students (Community Health Studies, Nursing in the Home) to advance practice in the context of policy and professional developments. A patchwork text was used to assess summatively what students achieved (practice change/development) and how this was informed critically, via an extended epistemology. First-person inquiry supplemented by cooperative inquiry postcourse completion (including reflective discussions with 16 students and 16 practice mentors) were used to assist coresearcher constructions of meaning. A relational, tripartite approach to learning and assessment (students', teachers', and practice mentors' collective contributions) depends on continuing reflective attention. Action learning enhances interrelation of experience with dialectic thinking. The patchwork text functions to promote creative writing, evaluative thinking, and praxis development. Role modeling by all, being genuine and not just "talking" genuine, is challenging yet crucial if people are to function as mutual resources for learning.

  20. Fiscal 1998 New Sunshine Program achievement report. Development for practical application of photovoltaic system - Development of thin-film solar cell manufacturing technology (Development of low-cost/large-area module manufacturing technology - Development of novel amorphous solar cell module manufacturing technology); 1998 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu seika hokokusho. Usumaku taiyo denchi no seizo gijutsu kaihatsu / tei cost daimenseki module seizo gijutsu kaihatsu (shingata amorphous taiyo denchi module no seizo gijutsu kaihatsu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    The project intends to improve on large-area amorphous silicon solar cell performance and to develop high-throughput manufacturing technologies for a reduction in the cost of modules. A film substrate type amorphous solar cell structure of the serial connection type named SCAF (series-connection through apertures formed on film) is contrived. Under this method, film formation using a stepping roll system newly developed for glass substrates may be applied, and the number of manhours required is allowed to be less than under conventional serial connection forming processes. The new technique is characterized in that serial connections are established via through-holes provided in plastic substrates. Making use of the technology, progress is attained in the development of high-throughput process technology for film substrate type amorphous solar cells and of efficiency enhancement technology. In fiscal 1997, an electron beam unit for plasma generation aiming at the elucidation of reaction processes in plasma was introduced, and technologies based on the equilibrium discharge technique were developed enabling high-speed a-Si film formation without degradation in film quality. The effect of trace boron addition to the tandem cell bottom I layer was investigated, and a stabilization rate of 8.05% was achieved using a 40cm times 80cm large SCAF cell. In fiscal 1998, endeavors were exerted for similar developments. (NEDO)

  1. The development of intensity modulated radiotherapy (IMRT) for prostate cancer at Austin and Repatriation Medical Centre (ARMC)

    International Nuclear Information System (INIS)

    Joon, D.L.; Mantle, C.; Viotto, A.; Rolfo, A.; Rykers, K.; Fernando, W.; Grace, M.; Liu, G.; Quong, G.; Feigen, M.; Wada, M.; Joon, M.L.; Fogarty, G.; Chao, M.W.; Khoo, V.

    2003-01-01

    To describe the protocol development of the IMRT program for prostate cancer at the ARMC. A series of protocols were defined and developed to facilitate the delivery of intensity modulated radiotherapy for prostate cancer. These included the following: 1. Physical Simulation including bowel and bladder preparation and immobilization 2. Image Acquisition including CT and MRI simulation scans with image co-registration 3. Contouring Definitions including target and organ at risk volumes as well as IMRT optimization and evaluation volumes 4. Radiotherapy Planning including constraint definition, inverse planning and CMS Focus specific parameters 5. DICOM RT interface including data transfer between CMS Focus and the Elekta Linac Desktop record and verify system 6. Verification including action limits and pre-treatment online EPID verification 7. Radiotherapy Delivery being that of step and shoot 8. Quality Assurance including physics testing and documentation The protocol development and testing has lead to the precise clinical delivery of IMRT for prostate cancer at ARMC that exceeds most of the parameters that were previously measured with our conventional and 3D conformal radiotherapy. Further development is now underway to allow it to be implemented as the routine treatment of prostate cancer at ARMC. The clinical implementation of IMRT for prostate cancer involves a collaborative team approach including radiation oncologists, radiation therapists, and radiation physics. This is necessary to develop the appropriate protocols and quality assurance for precision radiotherapy that is required for IMRT

  2. Current status of technology development for fabrication of Indian Test Blanket Module (TBM) of ITER

    Energy Technology Data Exchange (ETDEWEB)

    Jayakumar, T., E-mail: tjk@igcar.gov.in [Metallurgy and Materials Group, Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam 603102 (India); Rajendra Kumar, E. [TBM Division, Institute for Plasma Research (IPR), Bhat, Gandhinagar 382428 (India)

    2014-10-15

    Highlights: • Status of technology developments for Indian TBM to be installed in ITER is presented. • Procedure development for EB, laser and laser-hybrid welding of RAFM steel presented. • Filler wires for RAFM steel for TIG, NG-TIG and laser-hybrid welding have been developed. • Feasibility of production of channel plate by HIP technology has been demonstrated. - Abstract: Ever since India decided to install its Lead-Lithium Ceramic Breeder (LLCB) TBM in ITER, various technologies for fabrication of Indian TBM are being pursued by IPR and IGCAR, in collaboration with various research laboratories in India. Welding consumables for joining India specific RAFM steels (IN-RAFMS), procedures for hot isostatic pressing, electron beam welding, laser and laser-hybrid welding have been developed. Considering the complex nature and limited access available for inspection, innovative inspection procedures that involved use of phased array ultrasonic and C-scan imaging are also being pursued. This paper presents the current status of these developments and provides a roadmap for the future activities planned in realizing Indian TBM for testing in ITER.

  3. Development of Ethnoscience Approach in The Module Theme Substance Additives to Improve the Cognitive Learning Outcome and Student’s entrepreneurship

    Science.gov (United States)

    Sudarmin; Febu, R.; Nuswowati, M.; Sumarni, W.

    2017-04-01

    Ethnoscience approach is an interesting research today. The purpose of this research is to develop approaches ethnoscience and modules ethnoscience theme additives based ethnoscience; as well as assess the feasibility and effectiveness of module theme additives based ethnoscience to improve learning outcomes and the entrepreneurial character of students. This type of research is the Research and Development (R & D). In this research consist of four stages, namely define, design, development and implementation. The subjects of this study were students of the School of MTs Maarif NU Brebes. Data were analyzed by descriptive qualitative and quantitative. The results showed that ethnoscience approach and the module theme substance additives used declared worthy of National Education Standards Agency (BNSP) with an average percentage of validation on the feasibility aspect of the content, language feasibility, and feasibility of presenting respectively for 94.3%, 86 % and 92% and a very decent entry criteria. The effect of the application modules substance additive based ethnoscience can improve on the cognitive learning classical amounted to 90.63%, and increased learning outcomes category was based on the scores of N-gain. Influence ethnoscience approach application and module theme substances additives based ethnoscience able to improve the entrepreneurial character of students. Based on the results of this study concluded that the ethnoscience approach and module theme substance additives based ethnoscience effective to improve learning outcomes and students’ entrepreneurship.

  4. Rapid-X - An FPGA Development Toolset Using a Custom Simulink Library for MTCA.4 Modules

    Science.gov (United States)

    Prędki, Paweł; Heuer, Michael; Butkowski, Łukasz; Przygoda, Konrad; Schlarb, Holger; Napieralski, Andrzej

    2015-06-01

    The recent introduction of advanced hardware architectures such as the Micro Telecommunications Computing Architecture (MTCA) caused a change in the approach to implementation of control schemes in many fields. The development has been moving away from traditional programming languages ( C/C++), to hardware description languages (VHDL, Verilog), which are used in FPGA development. With MATLAB/Simulink it is possible to describe complex systems with block diagrams and simulate their behavior. Those diagrams are then used by the HDL experts to implement exactly the required functionality in hardware. Both the porting of existing applications and adaptation of new ones require a lot of development time from them. To solve this, Xilinx System Generator, a toolbox for MATLAB/Simulink, allows rapid prototyping of those block diagrams using hardware modelling. It is still up to the firmware developer to merge this structure with the hardware-dependent HDL project. This prevents the application engineer from quickly verifying the proposed schemes in real hardware. The framework described in this article overcomes these challenges, offering a hardware-independent library of components that can be used in Simulink/System Generator models. The components are subsequently translated into VHDL entities and integrated with a pre-prepared VHDL project template. Furthermore, the entire implementation process is run in the background, giving the user an almost one-click path from control scheme modelling and simulation to bit-file generation. This approach allows the application engineers to quickly develop new schemes and test them in real hardware environment. The applications may range from simple data logging or signal generation ones to very advanced controllers. Taking advantage of the Simulink simulation capabilities and user-friendly hardware implementation routines, the framework significantly decreases the development time of FPGA-based applications.

  5. Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos

    DEFF Research Database (Denmark)

    Dunworth, William P; Cardona-Costa, Jose; Bozkulak, Esra Cagavi

    2014-01-01

    : Our aim was to delineate the role of bone morphogenetic protein (BMP) 2 signaling in lymphatic development. METHODS AND RESULTS: BMP2 signaling negatively regulates the formation of LECs. Developing LECs lack any detectable BMP signaling activity in both zebrafish and mouse embryos, and excess BMP2...... signaling in zebrafish embryos and mouse embryonic stem cell-derived embryoid bodies substantially decrease the emergence of LECs. Mechanistically, BMP2 signaling induces expression of miR-31 and miR-181a in a SMAD-dependent mechanism, which in turn results in attenuated expression of prospero homeobox...

  6. Development and pilot testing of an online module for ethics education based on the Nigerian National Code for Health Research Ethics

    Science.gov (United States)

    2013-01-01

    Background The formulation and implementation of national ethical regulations to protect research participants is fundamental to ethical conduct of research. Ethics education and capacity are inadequate in developing African countries. This study was designed to develop a module for online training in research ethics based on the Nigerian National Code of Health Research Ethics and assess its ease of use and reliability among biomedical researchers in Nigeria. Methodology This was a three-phased evaluation study. Phase one involved development of an online training module based on the Nigerian Code of Health Research Ethics (NCHRE) and uploading it to the Collaborative Institutional Training Initiative (CITI) website while the second phase entailed the evaluation of the module for comprehensibility, readability and ease of use by 45 Nigerian biomedical researchers. The third phase involved modification and re-evaluation of the module by 30 Nigerian biomedical researchers and determination of test-retest reliability of the module using Cronbach’s alpha. Results The online module was easily accessible and comprehensible to 95% of study participants. There were significant differences in the pretest and posttest scores of study participants during the evaluation of the online module (p = 0.001) with correlation coefficients of 0.9 and 0.8 for the pretest and posttest scores respectively. The module also demonstrated excellent test-retest reliability and internal consistency as shown by Cronbach’s alpha coefficients of 0.92 and 0.84 for the pretest and posttest respectively. Conclusion The module based on the Nigerian Code was developed, tested and made available online as a valuable tool for training in cultural and societal relevant ethical principles to orient national and international biomedical researchers working in Nigeria. It would complement other general research ethics and Good Clinical Practice modules. Participants suggested that awareness of the

  7. Development and pilot testing of an online module for ethics education based on the Nigerian National Code for Health Research Ethics

    Directory of Open Access Journals (Sweden)

    Ogunrin Olubunmi A

    2013-01-01

    Full Text Available Abstract Background The formulation and implementation of national ethical regulations to protect research participants is fundamental to ethical conduct of research. Ethics education and capacity are inadequate in developing African countries. This study was designed to develop a module for online training in research ethics based on the Nigerian National Code of Health Research Ethics and assess its ease of use and reliability among biomedical researchers in Nigeria. Methodology This was a three-phased evaluation study. Phase one involved development of an online training module based on the Nigerian Code of Health Research Ethics (NCHRE and uploading it to the Collaborative Institutional Training Initiative (CITI website while the second phase entailed the evaluation of the module for comprehensibility, readability and ease of use by 45 Nigerian biomedical researchers. The third phase involved modification and re-evaluation of the module by 30 Nigerian biomedical researchers and determination of test-retest reliability of the module using Cronbach’s alpha. Results The online module was easily accessible and comprehensible to 95% of study participants. There were significant differences in the pretest and posttest scores of study participants during the evaluation of the online module (p = 0.001 with correlation coefficients of 0.9 and 0.8 for the pretest and posttest scores respectively. The module also demonstrated excellent test-retest reliability and internal consistency as shown by Cronbach’s alpha coefficients of 0.92 and 0.84 for the pretest and posttest respectively. Conclusion The module based on the Nigerian Code was developed, tested and made available online as a valuable tool for training in cultural and societal relevant ethical principles to orient national and international biomedical researchers working in Nigeria. It would complement other general research ethics and Good Clinical Practice modules. Participants

  8. Gibberellin modulates anther development in rice via the transcriptional regulation of GAMYB.

    Science.gov (United States)

    Aya, Koichiro; Ueguchi-Tanaka, Miyako; Kondo, Maki; Hamada, Kazuki; Yano, Kentaro; Nishimura, Mikio; Matsuoka, Makoto

    2009-05-01

    Gibberellins (GAs) play important roles in regulating reproductive development, especially anther development. Our previous studies revealed that the MYB transcriptional factor GAMYB, an important component of GA signaling in cereal aleurone cells, is also important for anther development. Here, we examined the physiological functions of GA during anther development through phenotypic analyses of rice (Oryza sativa) GA-deficient, GA-insensitive, and gamyb mutants. The mutants exhibited common defects in programmed cell death (PCD) of tapetal cells and formation of exine and Ubisch bodies. Microarray analysis using anther RNAs of these mutants revealed that rice GAMYB is involved in almost all instances of GA-regulated gene expression in anthers. Among the GA-regulated genes, we focused on two lipid metabolic genes, a cytochrome P450 hydroxylase CYP703A3 and beta-ketoacyl reductase, both of which might be involved in providing a substrate for exine and Ubisch body. GAMYB specifically interacted with GAMYB binding motifs in the promoter regions in vitro, and mutation of these motifs in promoter-beta-glucuronidase (GUS) transformants caused reduced GUS expression in anthers. Furthermore, a knockout mutant for CYP703A3 showed gamyb-like defects in exine and Ubisch body formation. Together, these results suggest that GA regulates exine formation and the PCD of tapetal cells and that direct activation of CYP703A3 by GAMYB is key to exine formation.

  9. Toward Development of a Fibromyalgia Responder Index and Disease Activity Score: OMERACT Module Update

    DEFF Research Database (Denmark)

    Mease, Philip J; Clauw, Daniel J; Christensen, Robin

    2011-01-01

    spondylitis represents heuristic models for our work, but FM is challenging in that there is no clear algorithm of treatment that defines disease activity based on treatment decisions, nor are there objective markers that define thresholds of severity or response to treatment. The process of developing...

  10. Consecutive Course Modules Developed with Simple Materials to Facilitate the Learning of Basic Concepts in Astronomy

    Science.gov (United States)

    Okulu, Hasan Zuhtu; Oguz-Unver, Ayse

    2015-01-01

    From the perspective of teaching, the huge natural laboratory that astronomy provides constitutes the most prominent connection between astronomy and other branches of science. The purpose of this research was to provide educators with activities of observation using simple materials that were developed to facilitate the teaching of basic concepts…

  11. A Knowledge Organization System for the Development of an ISO 19152:2012 LADM Valuation Module

    NARCIS (Netherlands)

    Çağdaş, Volkan; Kara, A.; Işıkdağ, Ümit; van Oosterom, P.J.M.; Lemmen, Christiaan; Stubkjær, Erik; Halme, Pekka

    2017-01-01

    The challenge to develop interactive information services for new domains is supported by Knowledge Organization Systems and Services (KOS), which model the underlying semantic structure of a domain through classification systems, thesauri, gazetteers, or ontologies. The ISO 19152:2012 Land

  12. Modulation of Attentional Blink with Emotional Faces in Typical Development and in Autism Spectrum Disorders

    Science.gov (United States)

    Yerys, Benjamin E.; Ruiz, Ericka; Strang, John; Sokoloff, Jennifer; Kenworthy, Lauren; Vaidya, Chandan J.

    2013-01-01

    Background: The attentional blink (AB) phenomenon was used to assess the effect of emotional information on early visual attention in typically developing (TD) children and children with autism spectrum disorders (ASD). The AB effect is the momentary perceptual unawareness that follows target identification in a rapid serial visual processing…

  13. MT1-MMP-mediated basement membrane remodeling modulates renal development

    International Nuclear Information System (INIS)

    Riggins, Karen S.; Mernaugh, Glenda; Su, Yan; Quaranta, Vito; Koshikawa, Naohiko; Seiki, Motoharu; Pozzi, Ambra; Zent, Roy

    2010-01-01

    Extracellular matrix (ECM) remodeling regulates multiple cellular functions required for normal development and tissue repair. Matrix metalloproteinases (MMPs) are key mediators of this process and membrane targeted MMPs (MT-MMPs) in particular have been shown to be important in normal development of specific organs. In this study we investigated the role of MT1-MMP in kidney development. We demonstrate that loss of MT1-MMP leads to a renal phenotype characterized by a moderate decrease in ureteric bud branching morphogenesis and a severe proliferation defect. The kidneys of MT1-MMP-null mice have increased deposition of collagen IV, laminins, perlecan, and nidogen and the phenotype is independent of the MT-1MMP target, MMP-2. Utilizing in vitro systems we demonstrated that MTI-MMP proteolytic activity is required for renal tubule cells to proliferate in three dimensional matrices and to migrate on collagen IV and laminins. Together these data suggest an important role for MT1-MMP in kidney development, which is mediated by its ability to regulate cell proliferation and migration by proteolytically cleaving kidney basement membrane components.

  14. The European ITER test blanket modules: Progress in development of fabrication technologies towards standardization

    Energy Technology Data Exchange (ETDEWEB)

    Zmitko, Milan, E-mail: milan.zmitko@f4e.europa.eu [Fusion for Energy (F4E), Josep Pla 2, Barcelona (Spain); Thomas, Noël [ATMOSTAT, F-94815 Villejuif (France); LiPuma, Antonella; Forest, Laurent [CEA-Saclay, DEN, DM2S, SEMT, F-91191 Gif-sur-Yvette (France); Cogneau, Laurence [CEA-DRT, 38000 Grenoble (France); Rey, Jörg; Neuberger, Heiko [Karlsruhe Institute of Technology (KIT), Postfach 3640, Karlsruhe (Germany); Poitevin, Yves [Fusion for Energy (F4E), Josep Pla 2, Barcelona (Spain)

    2016-11-01

    Highlights: • Significant progress on the development of welding procedures for European TBM achieved. • Fabrication processes feasibility based on diffusion and fusion welding demonstrated. • An optimized welding scenario/sequence for TBM box assembly identified. • Future qualification of pF/WPS proposed through realization of a number of QMUs. - Abstract: The paper reviews progress achieved in development of fabrication technologies and procedures applied for manufacturing of the TBM sub-components, like, HCLL and HCPB cooling plates, HCLL/HCPB stiffening plates, and HCLL/HCPB first wall and side caps. The used technologies are based on fusion and diffusion welding techniques taking into account specificities of the EUROFER97 steel. Development of a standardized procedure complying with professional codes and standards (RCC-MRx), a preliminary fabrication/welding procedure specification (pF/WPS), is described based on fabrication and non-destructive and destructive characterization of feasibility mock-ups (FMU) aimed at assessing the suitability of a fabrication process for fulfilling the design and fabrication specifications. The main FMUs characterization results are reported (e.g. pressure resistance and helium leak tightness tests, mechanical properties and microstructure at the weld joints, geometrical characteristics of the sub-components and internal cooling channels) and the key pF/WPS steps and parameters are outlined. Also, fabrication procedures for the TBM box assembly are presently under development for the establishment of an optimized assembly sequence/scenario and development of standardized welding procedure specifications. In conclusions, further steps towards the pF/WPS qualification are briefly discussed.

  15. The European ITER Test Blanket Modules: Current status of fabrication technologies development and a way forward

    Energy Technology Data Exchange (ETDEWEB)

    Zmitko, Milan, E-mail: milan.zmitko@f4e.europa.eu [Fusion for Energy (F4E), Josep Pla 2, Barcelona (Spain); Galabert, Jose [Fusion for Energy (F4E), Josep Pla 2, Barcelona (Spain); Thomas, Noël [ATMOSTAT, F-94815 Villejuif (France); Forest, Laurent [CEA-Saclay, DEN, DM2S, SEMT, F-91191 Gif-sur-Yvette (France); Bucci, Philippe; Cogneau, Laurence [CEA-DRT, 38000 Grenoble (France); Rey, Jörg; Neuberger, Heiko [Karlsruhe Institute of Technology (KIT), Postfach 3640, Karlsruhe (Germany); Poitevin, Yves [Fusion for Energy (F4E), Josep Pla 2, Barcelona (Spain)

    2015-10-15

    Highlights: • Significant progress on development of welding procedures for European TBM achieved. • Fabrication processes feasibility based on diffusion and fusion welding demonstrated. • TBM box assembly welding scenarios investigated and welding scenarios identified. • Future qualification of pF/WPS proposed through realization of a number of QMUs. - Abstract: The paper reviews fabrication technologies and procedures applied for manufacturing of the TBM sub-components, like, HCLL and HCPB cooling plates, HCLL/HCPB stiffening plates, and HCLL/HCPB first wall and side caps. The used technologies are based on fusion and diffusion welding techniques taking into account specificities of the EUROFER-97 steel. Development of a standardized procedure complying with professional codes and standards (RCC-MRx), a preliminary fabrication/welding procedure specification (pF/WPS), is described as well as a fabrication and characterization of feasibility mock-ups (FMU) aimed at assessing the suitability of a fabrication process for fulfilling the design and fabrication specifications. Also, fabrication procedures for the TBM box assembly are presently under development through collaboration between European Fusion Laboratories and Industry for the establishment of an optimized assembly sequence/scenario and development of standardized welding procedure specifications. Selection of optimized assembly scenario takes into accounts not only the design requirements and fabrication possibilities/constraints but also maximum accessibility to the welds for sound non-destructive examination in compliance with welds classification. A future approach towards qualification of the developed fabrication technologies and procedures, through a number of medium to full-size qualification mock-ups according to European standards, is outlined before construction of the first TBMs.

  16. Host modulation by a parasite: how Leishmania infantum modifies the intestinal environment of Lutzomyia longipalpis to favor its development.

    Directory of Open Access Journals (Sweden)

    Vania Cristina Santos

    Full Text Available Some reports have described the interference of Leishmania on sand flies physiology, and such behavior most likely evolved to favor the development and transmission of the parasite. Most of these studies showed that Leishmania could modulate the level of proteases in the midgut after an infective blood meal, and decreased proteolytic activity is indeed beneficial for the development of promastigotes in the gut of sand flies. In the present study, we performed a detailed investigation of the intestinal pH in Lutzomyia longipalpis females naturally infected with Leishmania infantum and investigated the production of trypsin by these insects using different approaches. Our results allowed us to propose a mechanism by which these parasites interfere with the physiology of L. longipalpis to decrease the production of proteolytic enzymes. According to our hypothesis L. infantum promastigotes indirectly interfere with the production of trypsin by modulating the mechanism that controls the intestinal pH via the action of a yet non-identified substance released by promastigote forms inside the midgut. This substance is not an acid, whose action would be restrict on to release H+ to the medium, but is a substance that is able to interfere with midgut physiology through a mechanism involving pH control. According to our hypothesis, as the pH decreases, the proteolytic enzymes efficiency is also reduced, leading to a decline in the supply of amino acids to the enterocytes: this decline reduces the stimulus for protease production because it is regulated by the supply of amino acids, thus leading to a delay in digestion.

  17. Fiscal 1998 New Sunshine Program achievement report. Development for practical application of photovoltaic system - Development of thin-film solar cell manufacturing technology (Development of low-cost large-area module manufacturing technology - Development of next-generation thin-film solar cell manufacturing technology - Development of thin-film polycrystalline solar cell module manufacturing technology); 1998 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu seika hokokusho. Usumaku taiyo denchi no seizo gijutsu kaihatsu / tei cost daimenseki module seizo gijutsu kaihatsu / jisedai usumaku taiyo denchi no seizo gijutsu kaihatsu (usumaku takessho taiyo denchi module no seizo gijutsu kaihatsu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    The aim is to realize the practical application of the above-named solar module expected to exhibit higher efficiency and reliability and achieve cost reduction through consumption of less materials. In fiscal 1998, 1) technologies were developed to reduce substrate warpage during recrystallization for the higher-throughput fabrication of high-quality thin films and 2) technologies were also developed for the realization of higher-throughput fabrication of thin films and for efficiency improvement for thin-film modules. Under item 1), experiments were conducted by simulation for reducing warpage to occur in thin-film polycrystalline Si substrates during fabrication by melting and recrystallization. Under item 2), for the development of thin-film cell high-throughput technologies, studies were started on a more practical hydrogen plasma process to challenge the conventional process of crystal defect inactivation by hydrogen ion injection with which achievement of high throughputs is difficult. For the development of technologies for the enhancement of thin-film module efficiency, efforts were exerted to realize a 10cm times 10cm square shape for the enhancement of efficiency in the process of filling modules with cells. These efforts achieved a great step toward future practical application. (NEDO)

  18. The European DISABKIDS project: development of seven condition-specific modules to measure health related quality of life in children and adolescents

    Directory of Open Access Journals (Sweden)

    Bullinger Monika

    2005-11-01

    Full Text Available Abstract Background The European DISABKIDS project aims to enhance the Health Related Quality of Life (HRQoL of children and adolescents with chronic medical conditions and their families. We describe the development of the seven cross-nationally tested condition-specific modules of the European DISABKIDS HRQoL instrument in a population of children and adolescents. The condition-specific modules are intended for use in conjunction with the DISABKIDS chronic generic module. Methods Focus groups were used to construct the pilot version of the DISABKIDS condition-specific HRQoL modules for asthma, juvenile idiopathic arthritis, atopic dermatitis, cerebral palsy, cystic fibrosis, diabetes and epilepsy. Analyses were conducted on pilot test data in order to construct field test versions of the modules. A series of factor analyses were run, first, to determine potential structures for each condition-specific module, and, secondly, to select a reduced number of items from the pilot test to be included in the field test. Post-field test analyses were conducted to retest the domain structure for the final DISABKIDS condition-specific modules. Results The DISABKIDS condition-specific modules were tested in a pilot study of 360 respondents, and subsequently in a field test of 1152 respondents in 7 European countries. The final condition-specific modules consist of an 'Impact' domain and an additional domain (e.g. worry, stigma, treatment with between 10 to 12 items in total. The Cronbach's alpha of the final domains was found to vary from 0.71 to 0.90. Conclusion The condition-specific modules of the DISABKIDS instrument were developed through a step-by-step process including cognitive interview, clinical expertise, factor analysis, correlations and internal consistency. A cross-national pilot and field test were necessary to collect these data. In general, the internal consistency of the domains was satisfactory to high. In future, the DISABKIDS

  19. Development of e-module combining science process skills and dynamics motion material to increasing critical thinking skills and improve student learning motivation senior high school

    Directory of Open Access Journals (Sweden)

    Fengky Adie Perdana

    2017-02-01

    Full Text Available Learning media is one of the most components in the teaching and learning process. This research was conducted to design and develop the electronic modules combining science process skills and dynamics motion content for increasing critical thinking skills and improve student learning motivation for senior high school. The Methods used in this research is Research and Development (R&D. Model research and development using a research 4D Thiagarajan model. Physics module was developed using science process skills approach: observing, formulating the problem, formulating a hypothesis, identify variables, conduct experiments, analyse the data, summarise and communicate. The results showed that: 1 the electronics module has been developed by integrating the science process skills for enhancing critical thinking skills and student motivation. 2 Electronic Module Physics-based science process skills meet the criteria very well, judging from the results of validation content, validation media, validation of peer education and practitioners, with an average value of 3.80 is greater than the minimum eligibility 3.78. 3 effectiveness the modules of science process skills got N-gain value obtained from a large trial in grade samples of 0.67 and 0.59 in the control group were categorised as moderate. 4 Implementation of electronic modules Physics-based science process skills is considered an effective to enhance the students' motivation. Statistical analysis showed a significance value of 0.027 is lower than the significance level α = 0.05, this means that there are significant differences between learning motivation grade sample and the control class. As a result of analysis data obtained from the research, it was seen that the students' motivation that uses Physics module based science process skills better than conventional learning.

  20. Helicobacter bilis Infection Alters Mucosal Bacteria and Modulates Colitis Development in Defined Microbiota Mice.

    Science.gov (United States)

    Atherly, Todd; Mosher, Curtis; Wang, Chong; Hostetter, Jesse; Proctor, Alexandra; Brand, Meghan W; Phillips, Gregory J; Wannemuehler, Michael; Jergens, Albert E

    2016-11-01

    Helicobacter bilis infection of C3H/HeN mice harboring the altered Schaedler flora (ASF) triggers progressive immune responsiveness and the development of colitis. We sought to investigate temporal alterations in community structure of a defined (ASF-colonized) microbiota in normal and inflamed murine intestines and to correlate microbiota changes to histopathologic lesions. The colonic mucosal microbiota of healthy mice and ASF mice colonized with H. bilis for 3, 6, or 12 weeks were investigated by fluorescence in situ hybridization targeting the 16S ribosomal RNA genes of total bacteria, group-specific organisms, and individual ASF bacterial species. Microbial profiling of ASF and H. bilis abundance was performed on cecal contents. Helicobacter bilis-colonized mice developed colitis associated with temporal changes in composition and spatial distribution of the mucosal microbiota. The number of total bacteria, ASF519, and helicobacter-positive bacteria were increased (P attachment, or by invasion, and this interaction is differentially expressed over time.