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Sample records for multiaxial stress system

  1. Stress factors for the deformation systems of zirconium under multiaxial stress

    International Nuclear Information System (INIS)

    Hobson, D.O.

    1976-01-01

    Calculation of the resolved shear stresses (rss) that act on various deformation systems in metals and, in particular, the determination of those systems subjected to the highest rss by a given set of multiaxial stresses is of importance in the study of texture development, yielding and plastic flow. This study examines the geometrical influences of any stress state on the deformation modes of zirconium. One slip mode and three twinning modes, comprising twenty-one deformation systems, are considered. Stress factors computed for these systems are shown on a coordinate system that allows specimen orientation, most highly stressed deformation system, and stress factor to be shown without ambiguity. The information in this report allows the determination of the rss that results from any multiaxial stress state; this information also allows the prediction of the deformation modes that might operate for any specimen orientation in that strss state

  2. Measurement of the forming limit stress curve using a multi-axial tube expansion test with a digital image correlation system

    Energy Technology Data Exchange (ETDEWEB)

    Hakoyama, Tomoyuki [Department of Mechanical Systems Engineering, Graduate school of Engineering, Tokyo University of Agriculture and Technology, 2-24-16, Nakacho, Koganei-shi, Tokyo, 184-8588 (Japan); Kuwabara, Toshihiko [Division of Advanced Mechanical Systems Engineering, Institute of Engineering, Tokyo University of Agriculture and Technology, 2-24-16, Nakacho, Koganei-shi, Tokyo, 184-8588 (Japan)

    2013-12-16

    A servo-controlled tension-internal pressure testing machine with an optical 3D deformation analysis system (ARAMIS) was used to measure the multi-axial plastic deformation behavior of a high-strength steel sheet for a range of strain from initial yield to fracture. The testing machine is capable of applying arbitrary principal stress or strain paths to a tubular specimen using an electrical, closed-loop servo-control system for axial force and internal pressure. Tubular specimens with an inner diameter of 44.6 mm were fabricated from a high-strength steel sheet with a tensile strength of 590 MPa and a thickness of 1.2 mm by roller bending and laser welding. Several linear and non-linear stress paths in the first quadrant of the stress space were applied to the tubular specimens in order to measure the forming limit curve (FLC) and forming limit stress curve (FLSC) of the as-received test material, in addition to the contours of plastic work and the directions of plastic strain rates. The contours of plastic work and the directions of plastic strain rates measured for the linear stress path experiments were compared with those calculated using selected yield functions in order to identify the most appropriate yield function for the test material. Moreover, a Marciniak-Kuczyński type (M-K) forming limit analysis was performed using the most appropriate yield function. The calculated and measured FLC and FLSC were compared in order to validate the M-K approach. The path-dependence of the FLC and FLSC was also investigated.

  3. Fracture criteria of reactor graphite under multiaxial stresses

    International Nuclear Information System (INIS)

    Sato, S.; Kawamata, K.; Kurumada, A.; Oku, T.

    1987-01-01

    New fracture criteria for graphite under multiaxial stresses are presented for designing core and support materials of a high temperature gas cooled reactor. Different kinds of fracture strength tests are carried out for a near isotropic graphite IG-11. Results show that, under the stress state in which tensile stresses are predominant, the maximum principal stress theory is seen as applicable for brittle fracture. Under the stress state in which compressive stresses are predominant there may be two fracture modes for brittle fracture, namely, slipping fracture and mode II fracture. For the former fracture mode the maximum shear stress criterion is suitable, but for the latter fracture mode a new mode II fracture criterion including a restraint effect for cracks is verified to be applicable. Also a statistical correction for brittle fracture criteria under multiaxial stresses is discussed. By considering the allowable stress values for safe design, the specified minimum ultimate strengths corresponding to a survival probability of 99% at the 95% confidence level are presented. (orig./HP)

  4. Material law for concrete under multiaxial stress

    International Nuclear Information System (INIS)

    Geistefeldt, H.

    1977-01-01

    In this paper a general triaxial set of finite strain-stress relations is derived, which can include a step-by-step way nearly all known factors and curves of material response. The finite constitutive equations representing the behaviour of concrete are related to the main strain-directions. The elastic part, the functions for uniaxial behaviour, those for biaxial response and finally the relation-parts, nonzero only in triaxial stress-state, can be reset separately by suitable functions which have been adjusted to the material response of actual concrete known from special tests. With a new and very short biaxial failure criterion for concrete, which has been stated and compared with test results, the analytic description of the biaxial behaviour of Kupfer's concrete is completed. With some additional assumptions the proposed failure criteria and the strain-stress equations for concrete are extended to the biaxial response of uncracked orthogonally reinforced concrete response. (Auth.)

  5. Material law for concrete under multiaxial stress

    International Nuclear Information System (INIS)

    Geistefeldt, H.

    1977-01-01

    In this paper a general triaxial set of finite strain-stress relations is derived, which can include in a step-by-step way nearly all known factors and curves of material response. The finite constitutive equations representing the behavior of concrete are related to the main strain-directions. The elastic part, the functions for uniaxial behavior, those for biaxial response and finally the relation-parts, nonzero only in triaxial stress-state, can be reset separately by suitable functions which have been adjusted to the material response of actual concrete known from special tests. In nonlinear incremental analysis a potential is usually assumed in incremental material behavior to keep incremental stiffness matrices symmetric. If the proposed generalized set of constitutive equations is restricted to special types of functions, the resulting tangent stiffness is symmetric. Special functions for the various parts are presented, the tangent stiffness of which can easily be derived explicitly by partial differentiation of the related strain-stress relations. Thus the application of the proposed constitutive equations in incremental nonlinear analysis is very effective. The free coefficients of one general set of equations are adjusted step by step to the results of Kupfer's biaxial tests under shorttime loading. With a new and very short bixial failure criterion for concrete, which has been stated and compared with test results, the analytic description of the biaxial behavior of Kupfer's concrete is completed. With some additional assumptions the proposed failure criteria and the strain-stress equations for concrete are extended to the biaxial response of uncracked othogonally reinforced concrete response

  6. Multiaxis, Lightweight, Computer-Controlled Exercise System

    Science.gov (United States)

    Haynes, Leonard; Bachrach, Benjamin; Harvey, William

    2006-01-01

    The multipurpose, multiaxial, isokinetic dynamometer (MMID) is a computer-controlled system of exercise machinery that can serve as a means for quantitatively assessing a subject s muscle coordination, range of motion, strength, and overall physical condition with respect to a wide variety of forces, motions, and exercise regimens. The MMID is easily reconfigurable and compactly stowable and, in comparison with prior computer-controlled exercise systems, it weighs less, costs less, and offers more capabilities. Whereas a typical prior isokinetic exercise machine is limited to operation in only one plane, the MMID can operate along any path. In addition, the MMID is not limited to the isokinetic (constant-speed) mode of operation. The MMID provides for control and/or measurement of position, force, and/or speed of exertion in as many as six degrees of freedom simultaneously; hence, it can accommodate more complex, more nearly natural combinations of motions and, in so doing, offers greater capabilities for physical conditioning and evaluation. The MMID (see figure) includes as many as eight active modules, each of which can be anchored to a floor, wall, ceiling, or other fixed object. A cable is payed out from a reel in each module to a bar or other suitable object that is gripped and manipulated by the subject. The reel is driven by a DC brushless motor or other suitable electric motor via a gear reduction unit. The motor can be made to function as either a driver or an electromagnetic brake, depending on the required nature of the interaction with the subject. The module includes a force and a displacement sensor for real-time monitoring of the tension in and displacement of the cable, respectively. In response to commands from a control computer, the motor can be operated to generate a required tension in the cable, to displace the cable a required distance, or to reel the cable in or out at a required speed. The computer can be programmed, either locally or via

  7. Multiaxial Stress-Strain Modeling and Effect of Additional Hardening due to Nonproportional Loading

    International Nuclear Information System (INIS)

    Rashed, G.; Ghajar, R.; Farrahi, G.

    2007-01-01

    Most engineering components are subjected to multiaxial rather than uniaxial cyclic loading, which causes multiaxial fatigue. The pre-requisite to predict the fatigue life of such components is to determine the multiaxial stress strain relationship. In this paper the multiaxial cyclic stress-strain model under proportional loading is derived using the modified power law stress-strain relationship. The equivalent strain amplitude consisted of the normal strain excursion and maximum shear strain amplitude is used in the proportional model to include the additional hardening effect due to nonproportional loading. Therefore a new multiaxial cyclic stress-strain relationship is devised for out of phase nonproportional loading. The model is applied to the nonproportional loading case and the results are compared with the other researchers' experimental data published in the literature, which are in a reasonable agreement with the experimental data. The relationship presented here is convenient for the engineering applications

  8. A review of creep analysis and design under multi-axial stress states

    International Nuclear Information System (INIS)

    Yao, H.-T.; Xuan Fuzhen; Wang Zhengdong; Tu Shantung

    2007-01-01

    The existence of multi-axial states of stress cannot be avoided in elevated temperature components. It is essential to understand the associated failure mechanisms and to predict the lifetime in practice. Although metal creep has been studied for about 100 years, many problems are still unsolved, in particular for those involving multi-axial stresses. In this work, a state-of-the-art review of creep analysis and engineering design is carried out, with particular emphasis on the effect of multi-axial stresses. The existing theories and creep design approaches are grouped into three categories, i.e., the classical plastic theory (CPT) based approach, the cavity growth mechanism (CGM) based approach and the continuum damage mechanics (CDM) based approach. Following above arrangements, the constitutive equations and design criteria are addressed. In the end, challenges on the precise description of the multi-axial creep behavior and then improving the strength criteria in engineering design are presented

  9. A study on multi-axial fatigue model based on structural stress

    International Nuclear Information System (INIS)

    Kim, Cheol; Kim, Jong Sung; Jin, Tae Eun; Dong, P.

    2004-01-01

    In nuclear components, cyclic loadings that cause complex states of stress are common. Through a reference review, four sources of the multi-axial fatigue data were collected from LBF, University of Illinois, EPRI, and TWI. All these tests were conducted using tube to flange specimens with a circumferential fillet welds. The loading conditions were mostly bending/ torsion combinations, except that TWI used tension/ torsion combinations. None of fatigue correlation parameters have been demonstrated to be satisfactory in correlating the multi-axial fatigue data outside of their own. In this paper, we proposed the characterizing multi-axial fatigue behavior in terms of the structural stress methods by using some of the well-known multi-axial fatigue data available in the references

  10. Constitutive relations describing creep deformation for multi-axial time-dependent stress states

    Science.gov (United States)

    McCartney, L. N.

    1981-02-01

    A THEORY of primary and secondary creep deformation in metals is presented, which is based upon the concept of tensor internal state variables and the principles of continuum mechanics and thermodynamics. The theory is able to account for both multi-axial and time-dependent stress and strain states. The wellknown concepts of elastic, anelastic and plastic strains follow naturally from the theory. Homogeneous stress states are considered in detail and a simplified theory is derived by linearizing with respect to the internal state variables. It is demonstrated that the model can be developed in such a way that multi-axial constant-stress creep data can be presented as a single relationship between an equivalent stress and an equivalent strain. It is shown how the theory may be used to describe the multi-axial deformation of metals which are subjected to constant stress states. The multi-axial strain response to a general cyclic stress state is calculated. For uni-axial stress states, square-wave loading and a thermal fatigue stress cycle are analysed.

  11. Multiaxial fatigue assessment of welded joints using the notch stress approach

    DEFF Research Database (Denmark)

    Pedersen, Mikkel Melters

    2016-01-01

    This paper presents an evaluation of the safety involved when performing fatigue assessment of multiaxially loaded welded joints. The notch stress approach according to the IIW is used together with 8 different multiaxial criteria, including equivalent stress-, interaction equation- and critical...... plane approaches. The investigation is carried out by testing the criteria on a large amount of fatigue test results collected from the literature (351 specimens total). Subsequently, the probability of achieving a non-conservative fatigue assessment is calculated in order to evaluate the different...

  12. Classification of Headache Disorders: Extending to a Multiaxial System.

    Science.gov (United States)

    Martin, Paul R

    2016-11-01

    This article argues for extending the International Classification of Headache Disorders to include information that goes beyond diagnosis. The obvious model is a multiaxial system as has been developed for other taxonomies. An axis for recording disability and impact on functioning, and an axis for recording the triggers of headache/migraine, are perhaps the strongest contenders for adding to the system, but there are other possibilities such as lifestyle factors relevant to headache. Extensions such as these would contribute to headache management, provide clear targets for change, and encourage adoption of a biopsychosocial perspective. © 2016 American Headache Society.

  13. Fast assessment of the critical principal stress direction for multiple separated multiaxial loadings

    Directory of Open Access Journals (Sweden)

    M. Cova

    2015-07-01

    Full Text Available The critical plane calculation for multiaxial damage assessment is often a demanding task, particularly for large FEM models of real components. Anyway, in actual engineering requests, sometime, it is possible to take advantage of the specific properties of the investigated case. This paper deals with the problem of a mechanical component loaded by multiple, but “time-separated”, multiaxial external loads. The specific material damage is dependent from the max principal stress variation with a significant mean stress sensitivity too. A specifically fitted procedure was developed for a fast computation, at each node of a large FEM model, of the direction undergoing the maximum fatigue damage; the procedure is defined according to an effective stress definition based on the max principal stress amplitude and mean value. The procedure is presented in a general form, applicable to the similar cases.

  14. The effect of multi-axiality on damage with alternating stress

    International Nuclear Information System (INIS)

    Hug, J.; Zenner, H.; Schram, A.

    1992-01-01

    The aim of this project is a better understanding of the development of damage with multi-axial alternating stress. Hollow samples of the materials X6 CrNiTi 18 0 and Ck 15 are submitted to equal phase, phase displaced and consecutively alternating normal and thrust stresses. The amplitude ratio τ/σ is 1/2. Apart from the service life, the cyclic alternating deformation behaviour and the initiation and prapagation of microcracks are examined. (orig./MM) [de

  15. Design of a multi-axis implantable MEMS sensor for intraosseous bone stress monitoring

    International Nuclear Information System (INIS)

    Alfaro, Fernando; Weiss, Lee; Campbell, Phil; Fedder, Gary K; Miller, Mark

    2009-01-01

    The capability to assess the biomechanical properties of living bone is important for basic research as well as the clinical management of skeletal trauma and disease. Even though radiodensitometric imaging is commonly used to infer bone quality, bone strength does not necessarily correlate well with these non-invasive measurements. This paper reports on the design, fabrication and initial testing of an implantable ultra-miniature multi-axis sensor for directly measuring bone stresses at a micro-scale. The device, which is fabricated with CMOS-MEMS processes, is intended to be permanently implanted within open fractures, or embedded in bone grafts, or placed on implants at the interfaces between bone and prosthetics. The stress sensor comprises an array of piezoresistive pixels to detect a stress tensor at the interfacial area between the MEMS chip and bone, with a resolution to 100 Pa, in 1 s averaging. The sensor system design and manufacture is also compatible with the integration of wireless RF telemetry, for power and data retrieval, all within a 3 mm × 3 mm × 0.3 mm footprint. The piezoresistive elements are integrated within a textured surface to enhance sensor integration with bone. Finite element analysis led to a sensor design for normal and shear stress detection. A wired sensor was fabricated in the Jazz 0.35 µm BiCMOS process and then embedded in mock bone material to characterize its response to tensile and bending loads up to 250 kPa

  16. Practical application of fracture mechanics with consideration of multiaxiality of stress state to degraded nuclear piping

    International Nuclear Information System (INIS)

    Kussmaul, K.; Blind, D.; Herter, K.H.; Eisele, U.; Schuler, X.

    1995-01-01

    Within the scope of a research project nuclear piping components (T-branches and elbows) with dimensions like the primary coolant lines of PWR plants were investigated. In addition to the experimental full scale tests, extensive numerical calculations by means of the finite element method (FEM) as well as fracture mechanics analyses were performed. The applicability of these methods was verified by comparison with the experimental results. The calculation of fracture mechanics parameters as well as the calculated component stress enabled a statement on crack initiation. The failure behavior could be evaluated by means of the multiaxiality of stress state in the ligament (gradient of the quotient of the multiaxiality of stress state q). With respect to practical application on other pressurized components it is shown how to use the procedure (e.g. in a LBB analysis). A quantitative assessment with regard to crack initiation is possible by comparison of the effective crack initiation value J ieff with the calculated component stress. If the multiaxiality of stress state and the q gradient in the ligament of the fracture ligament of the fracture mechanics specimen and the pressurized component to be evaluated is comparable a quantitative assessment is possible as for crack extension and maximum load. If there is no comparability of the gradients a qualitative assessment is possible for the failure behavior

  17. X-ray multiaxial stress analysis by means of polynomial approximation and an application to plane stress problem

    International Nuclear Information System (INIS)

    Yoshioka, Yasuo; Sasaki, Toshihiko; Kuramoto, Makoto.

    1984-01-01

    A new polynomial approximation method was proposed for the X-ray multiaxial stress analysis, in which the effect of stress gradient along the penetration depth of X-rays was taken into account. Three basic assumptions were made; (1) the stress gradient is linear in respect to the depth from the specimen surface, (2) the ponetration depth of X-rays is a function of Sin 2 phi and (3) the strain measured by X-rays corresponds to the weighted average strain on the intensity of the diffracted X-rays. Consequently, the stress state within the thin layer near the surface was expressed by making use of three surface stresses and six stress gradients in the present method. The average strains by X-rays were approximated by the third order polynomial equations of sin 2 phi using a least square method at several phi angles on the coordinate system of specimen. Since the coefficients of these polynomials include these nine stress components mentioned above, it is possible to solve them as simultaneous equations. The calculating process of this method is simpler than that of the integral method. An X-ray plane stress problem was analyzed as an application of the present method, and the residual stress distribution on a shot-peened steel plate was actually measured by use of Cr-Kα X-rays to verify the analysis. The result showed that the compressive residual stress near the surface determined by the present method was smaller than the weighted average stress by the Sin 2 phi method because of the steep stress gradient. The present method is useful to obtain a reasonable value of stress for such a specimen with steep stress gradients near the surface. (author)

  18. Cycle counting procedure for fatigue failure preditions for complicated multi-axial stress histories

    International Nuclear Information System (INIS)

    Jones, D.P.; Friedrich, C.M.; Hoppe, R.G.

    1977-12-01

    A procedure has been developed to determine the cumulative fatigue damage in structures experiencing complicated multi-axial stress histories. The procedure is a generalization of the rainflow method developed by Matsuishi and Endo for one-dimensional situations. It provides a consistent treatment of three-dimensional stress states that is especially suited to computer programming applications for the post-processing of finite element stress data. The procedure includes a unique method to account for the rotation of principal stresses with time during the stress history and for the cumulative fatigue damage resulting from partial stress reversals within a stress cycle. The general procedure and necessary equations for programming are presented. Comparisons are made with life predictions using Section III of the ASME Boiler and Pressure Vessel Code for two hypothetical multi-axial stress histories for which the principal stresses are rotating with time. These comparisons show that the cycle counting method provides a consistent unambiguous interpretation of the fatigue design procedure in the ASME Code for these cases. Finally, the fatigue life of a perforated plate, as analyzed by finite elements, is computed for the combination of several hypothetical stress histories. This example demonstrates the utility of the proposed method when used in conjunction with finite element programs

  19. Slow strain rate stress corrosion cracking under multiaxial deformation conditions: technique and application to admiralty brass

    International Nuclear Information System (INIS)

    Blanchard, W.K.; Heldt, L.A.; Koss, D.

    1984-01-01

    A set of straightforward experimental techniques are described for the examination of slow strain rate stress corrosion cracking (SCC) of sheet deforming under nearly all multiaxial deformation conditions which result in sheet thinning. Based on local fracture strain as a failure criterion, the results contrast stress corrosion susceptibility in uniaxial tension with those in both plane strain and balanced biaxial tension. These results indicate that the loss of ductility of the brass increases as the stress state changes from uniaxial toward balanced biaxial tension

  20. Multiaxial stress analysis taking account of the penetration depth of x-rays, (1)

    International Nuclear Information System (INIS)

    Sasaki, Toshihiko; Yoshioka, Yasuo; Kuramoto, Makoto.

    1983-01-01

    The new theory of X-ray multiaxial stress measurement is proposed. This method takes accounts of the influence concerning to the stress gradient and to the dependence of the penetration depth of X-rays upon the incidence angle. As a basic assumption, it's assumed that (1) stress gradient is linear in respect to the depth from the specimen surface, (2) the penetration depth of X-rays shows linear dependence upon sin 2 PSI, and (3) the lattice strain determined by X-rays corresponds to the weighted averaging strain on the intensity of the diffracted X-rays. Consequently, the stress state within the thin layer near to the surface is expressed by making use of three surface stresses and six stress gradients in this theory. It was proved that these nine stress elements were able to be solved through X-ray method by applying ''the integral method'' proposed by Lode and Peiter in 1976. The verification of the validity on this method was carried out through the numerical simulation and residual stress measurement of a ground S55C. As a result, it was found that this method could get a satisfactory accuracy. This method can estimate the multiaxial stress distribution within the surface layer nondestructively. (author)

  1. On the impact of multi-axial stress states on trailing edge bondlines in wind turbine rotor blades

    Science.gov (United States)

    Noever Castelos, Pablo; Balzani, Claudio

    2016-09-01

    For a reliable design of wind turbine systems all of their components have to be designed to withstand the loads appearing in the turbine's lifetime. When performed in an integral manner this is called systems engineering, and is exceptionally important for components that have an impact on the entire wind turbine system, such as the rotor blade. Bondlines are crucial subcomponents of rotor blades, but they are not much recognized in the wind energy research community. However, a bondline failure can lead to the loss of a rotor blade, and potentially of the entire turbine, and is extraordinarily relevant to be treated with strong emphasis when designing a wind turbine. Modern wind turbine rotor blades with lengths of 80 m and more offer a degree of flexibility that has never been seen in wind energy technology before. Large deflections result in high strains in the adhesive connections, especially at the trailing edge. The latest edition of the DNV GL guideline from end of 2015 demands a three-dimensional stress analysis of bondlines, whereas before an isolated shear stress proof was sufficient. In order to quantify the lack of safety from older certification guidelines this paper studies the influence of multi-axial stress states on the ultimate and fatigue load resistance of trailing edge adhesive bonds. For this purpose, detailed finite element simulations of the IWES IWT-7.5-164 reference wind turbine blades are performed. Different yield criteria are evaluated for the prediction of failure and lifetime. The results show that the multi-axial stress state is governed by span-wise normal stresses. Those are evidently not captured in isolated shear stress proofs, yielding non-conservative estimates of lifetime and ultimate load resistance. This finding highlights the importance to include a three-dimensional stress state in the failure analysis of adhesive bonds in modern wind turbine rotor blades, and the necessity to perform a three-dimensional characterization

  2. Natural fiber composite design and characterization for limit stress prediction in multiaxial stress state

    Directory of Open Access Journals (Sweden)

    Christopher C. Ihueze

    2015-07-01

    Full Text Available This paper focuses on the design of natural fiber composites and analysis of multiaxial stresses in relation to yield limit stresses of composites loaded off the fibers axis. ASTM D638-10 standard for tensile test was used to design and compose composites of plantain fiber reinforced polyester (PFRP. While the rule of mixtures was used in the evaluation of properties of composites in the fiber direction the evaluation of properties perpendicular or transverse to the fiber direction was done based on the value of the orthogonal stresses evaluated using ANSYS finite element software, the application of the Brintrup equation and Halpin–Tai equation. The yield strength for the plantain empty fruit bunch fiber reinforced polyester resin (PEFBFRP was estimated as 33.69 MPa while the yield strength of plantain pseudo stem fiber reinforced polyester resin (PPSFRP was estimated as 29.24 MPa. Above all, the PEFBFRP with average light absorbance peak of 45.47 was found to have better mechanical properties than the PPSFRP with average light absorbance peak of 45.77.

  3. Ability of multiaxial fatigue criteria accounting for stress gradient effect for surface defective material

    Directory of Open Access Journals (Sweden)

    Niamchaona Wichian

    2018-01-01

    Full Text Available New high strength steels are widely used nowadays in many industrial areas as in automotive industry. These steels are more resistant and provide higher fatigue limits than latter ones but they are also more sensible to small defects. Natural defects that outcome from metallurgy (as shrinkage, inclusion, void are not considered in this study. We focus on small manufacturing defects such as cutting edge defects generated by punching or other surface defects due to stamping. These defects are harmful on the material fatigue behaviour due to high stress concentration at defects root. They also generate stress gradient that is beneficial from the fatigue strength point of view. This study focusses on the stress gradient (it does not account for the size effect from cylindrical defect on specimen edge. Practically a normal stress gradient is added in multiaxial fatigue criteria formulation. Both critical plane approach and integral approach are involved in the present study. This gradient is calculated from stress states at defects root by using FEM. Criteria fatigue function at N cycles is used to assess the material fatigue strength. Obviously multiaxial fatigue criteria accounting for stress gradient give more precise fatigue functions than criteria that do not consider the gradient influence.

  4. Multiaxial Fatigue Properties of 2A12 Aluminum Alloy Under Different Stress Amplitude Ratio Loadings

    Directory of Open Access Journals (Sweden)

    CHEN Ya-jun

    2017-09-01

    Full Text Available The multiaxial fatigue behavior of 2A12 aluminum alloy was studied with SDN100/1000 electro-hydraulic servo tension-torsion fatigue tester under different stress amplitude ratios, the fracture morphology and the fatigue loading curve were observed to study the failure mechanism. The results show that, under the one stage loading condition, the fatigue life prolongs with the stress amplitude ratio increasing. Under pure torsion loading, smooth and even area exists in the fracture surface. As the stress amplitude ratio increases, the number of scratch reduces, the fatigue striation and some special morphology such as the fishbone pattern, scale pattern and honeycomb pattern can be observed; under cumulative paths of different stress amplitude ratios, the variation of multiaxial fatigue life changes with first stage loading cycles; under cumulative paths of high-low stress amplitude ratio, the cycle hardening occurs obviously in the axial direction for the first stage high stress amplitude ratio loading and 2A12 alloy shows training effect.

  5. ELESTRES: performance of nuclear fuel, circumferential ridging, and multiaxial elastic-plastic stresses in sheaths

    International Nuclear Information System (INIS)

    Tayal, M.

    1986-10-01

    The finite element code ELESTRES models the two-dimensional axisymmetric behaviour of a CANDU fuel element during normal operation. The main focus of the code is to estimate temperatures, fission gas release, and axial variations of deformation/stresses in the pellet and in the sheath. Thus the code is able to predict details like stresses/strains at circumferential ridges. This paper describes the current version of ELESTRES. The emphasis is on a recent addition: multiaxial stresses in the sheath near circumferential ridges. For accuracy in the critical region, a fine mesh is used near the ridge. To keep computing costs low, a coarse mesh is used near the midplane of the pellet. Predictions of ELESTRES show good agreement with abouth 80 measurements of fission-gas-release. In this paper, we also present ELESTRES predictions of hoop strains in sheaths, for two irradiations: element ABS and bundle GB. For both irradiations, predictions, compare favourably with measurements. An illustrative example shows that near circumferential ridges, bending contributes to multiaxial stresses in the sheath. This can have a significant effect on sheath integrity, such as during stress-corrosion-cracking due to power-increases, or during corrosion-assisted-fatigue due to power cycling

  6. Crack formation and crack propagation under multiaxial mechanical and thermal stresses. Proceedings

    International Nuclear Information System (INIS)

    1993-01-01

    The 25th meeting of the DV Fracture Group was held on 16/17 February 1993 at Karlsruhe Technical University. The main topic, ''Crack formation and crack propagation under multiaxial mechanical and thermal stresses'', was discussed by five invited papers (by K.J. Miller, D. Loehe, H.A. Richard, W. Brocks, A. Brueckner-Foit) and 23 short papers. The other 21 papers were devoted to various domains of fracture mechanics, with emphasis on elastoplastic fracture mechanics. (orig./MM) [de

  7. Current state of low-cycle fatigue research based on multiaxial stress intensity and its challenges. Part 1. Focusing on low-cycle fatigue strength evaluation method of elbow piping subjected to in-plane cyclic bending displacement load

    International Nuclear Information System (INIS)

    Urabe, Yoshio

    2017-01-01

    The R and D of fatigue strength at multiaxial stress intensity is recognized to become extremely important in the future in terms of the elaboration of low-cycle fatigue evaluation of various structures including piping systems and reflection on those standards. This paper focuses on the evaluation method developed by the author, namely cumulative damage rule in consideration of multiaxial stress intensity, and explains the concept and the results of verification and evaluation. It also discusses the engineering problems of the current low cycle fatigue assessment technology that were clarified in the process of developing low-cycle fatigue assessment method based on multiaxial stress intensity. The conservative lifespan and somewhat more conservative actual lifetime of elbow piping can be estimated by the conventional 'revised universal slope method' and 'advanced revised universal slope method.' However, these are empirical rules, and the theoretical basis is not clear. From 'cumulative damage rule in consideration of multiaxial stress intensity,' the author calculated furthermore 'low cycle fatigue evaluation formula based on cumulative damage rule in consideration of multi-axial stress intensity,' and examined it. As a result, an evaluation formula that can reasonably assume the equivalent thermoplastic strain range could be obtained at half of the repeat count as targeted. Furthermore, at the stage where future high precision FEM analysis can be used, direct low-cycle fatigue life curve can be established. (A.O.)

  8. The effect of hydrogen on the multiaxial stress-strain behavior of titanium tubing

    International Nuclear Information System (INIS)

    Lentz, C.W.; Hecker, S.S.; Koss, D.A.; Stout, M.G.

    1983-01-01

    The influence of internal hydrogen on the multiaxial stress-strain behavior of commercially pure titanium has been studied. Thin-walled specimens containing either 20 or 1070 ppm hydrogen were tested at constant stress ratios in combined tension and internal pressure. Hydrogen lowers the yield strength but has no significant effect on strain hardening behavior at strains epsilon greater than or equal to 0.02. Thus, hydrogen embrittlement under plain strain or equibiaxial loading is not a consequence of changes of flow behavior. The yielding behavior is described well by Hill's quadratic yield criterion. As measured mechanically and pole figure analysis, the plastic anisotropy changes with deformation in a manner which depends on stress state. A strain dependent, texture-induced strengthening effect in equibiaxial tension an enhanced strain hardening rate

  9. Damage evolution under cyclic multiaxial stress state: A comparative analysis between glass/epoxy laminates and tubes

    DEFF Research Database (Denmark)

    Quaresimin, M.; Carraro, P.A.; Mikkelsen, Lars Pilgaard

    2014-01-01

    In this work an experimental investigation on damage initiation and evolution in laminates under cyclic loading is presented. The stacking sequence [0/θ2/0/-θ2]s has been adopted in order to investigate the influence of the local multiaxial stress state in the off-axis plies and the possible effect...

  10. Assessment of Creep Deformation, Damage, and Rupture Life of 304HCu Austenitic Stainless Steel Under Multiaxial State of Stress

    Science.gov (United States)

    Sahoo, K. C.; Goyal, Sunil; Parameswaran, P.; Ravi, S.; Laha, K.

    2018-03-01

    The role of the multiaxial state of stress on creep deformation and rupture behavior of 304HCu austenitic stainless steel was assessed by performing creep rupture tests on both smooth and notched specimens of the steel. The multiaxial state of stress was introduced by incorporating circumferential U-notches of different root radii ranging from 0.25 to 5.00 mm on the smooth specimens of the steel. Creep tests were carried out at 973 K over the stress range of 140 to 220 MPa. In the presence of notch, the creep rupture strength of the steel was found to increase with the associated decrease in rupture ductility. Over the investigated stress range and notch sharpness, the strengthening was found to increase drastically with notch sharpness and tended toward saturation. The fractographic studies revealed the mixed mode of failure consisting of transgranular dimples and intergranular creep cavitation for shallow notches, whereas the failure was predominantly intergranular for relatively sharper notches. Detailed finite element analysis of stress distribution across the notch throat plane on creep exposure was carried out to assess the creep failure of the material in the presence of notch. The reduction in von-Mises stress across the notch throat plane, which was greater for sharper notches, increased the creep rupture strength of the material. The variation in fracture behavior of the material in the presence of notch was elucidated based on the von-Mises, maximum principal, and hydrostatic stresses. Electron backscatter diffraction analysis of creep strain distribution across the notch revealed localized creep straining at the notch root for sharper notches. A master curve for predicting creep rupture life under the multiaxial state of stress was generated considering the representative stress having contributions from both the von-Mises and principal stress components of the stress field in the notch throat plane. Rupture ductility was also predicted based on the

  11. The effect of multiaxial stress state on creep behavior and fracture mechanism of P92 steel

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Yuan; Xu, Hong, E-mail: xuhong@ncepu.edu.cn; Ni, Yongzhong; Lan, Xiang; Li, Hongyuan

    2015-06-11

    The creep experiments on plain and double U-typed notched specimens were conducted on P92 steel at 650 °C. The notch strengthening effect was found in the notched specimens. Fracture appearance observed by scanning electron microscopy revealed that dimpled fracture for relatively blunt notched specimen, and dimpled fracture doubled with intergranular brittle fracture for relatively sharp notched specimen, which meant that fracture mechanism of P92 steel altered due to the presence of the notch. Meanwhile, based on Norton–Bailey and Kachanov–Robotnov constitutive models, a modified model was proposed. Finite element simulations were carried out to investigate the effect of multiaxial stress state on the creep behavior, fracture mechanism and damage evolvement of P92 steel. The simulation results agreed well with the fracture behaviors observed experimentally.

  12. Fatigue Behavior under Multiaxial Stress States Including Notch Effects and Variable Amplitude Loading

    Science.gov (United States)

    Gates, Nicholas R.

    The central objective of the research performed in this study was to be able to better understand and predict fatigue crack initiation and growth from stress concentrations subjected to complex service loading histories. As such, major areas of focus were related to the understanding and modeling of material deformation behavior, fatigue damage quantification, notch effects, cycle counting, damage accumulation, and crack growth behavior under multiaxial nominal loading conditions. To support the analytical work, a wide variety of deformation and fatigue tests were also performed using tubular and plate specimens made from 2024-T3 aluminum alloy, with and without the inclusion of a circular through-thickness hole. However, the analysis procedures implemented were meant to be general in nature, and applicable to a wide variety of materials and component geometries. As a result, experimental data from literature were also used, when appropriate, to supplement the findings of various analyses. Popular approaches currently used for multiaxial fatigue life analysis are based on the idea of computing an equivalent stress/strain quantity through the extension of static yield criteria. This equivalent stress/strain is then considered to be equal, in terms of fatigue damage, to a uniaxial loading of the same magnitude. However, it has often been shown, and was shown again in this study, that although equivalent stress- and strain-based analysis approaches may work well in certain situations, they lack a general robustness and offer little room for improvement. More advanced analysis techniques, on the other hand, provide an opportunity to more accurately account for various aspects of the fatigue failure process under both constant and variable amplitude loading conditions. As a result, such techniques were of primary interest in the investigations performed. By implementing more advanced life prediction methodologies, both the overall accuracy and the correlation of fatigue

  13. Review of Response and Damage of Linear and Nonlinear Systems under Multiaxial Vibration

    Directory of Open Access Journals (Sweden)

    Ed Habtour

    2014-01-01

    Full Text Available A review of past and recent developments in multiaxial excitation of linear and nonlinear structures is presented. The objective is to review some of the basic approaches used in the analytical and experimental methods for kinematic and dynamic analysis of flexible mechanical systems, and to identify future directions in this research area. In addition, comparison between uniaxial and multiaxial excitations and their impact on a structure’s life-cycles is provided. The importance of understanding failure mechanisms in complex structures has led to the development of a vast range of theoretical, numerical, and experimental techniques to address complex dynamical effects. Therefore, it is imperative to identify the failure mechanisms of structures through experimental and virtual failure assessment based on correctly identified dynamic loads. For that reason, techniques for mapping the dynamic loads to fatigue were provided. Future research areas in structural dynamics due to multiaxial excitation are identified as (i effect of dynamic couplings, (ii modal interaction, (iii modal identification and experimental methods for flexible structures, and (iv computational models for large deformation in response to multiaxial excitation.

  14. Multiaxial stress analysis taking account of penetration depth of x-rays, 3

    International Nuclear Information System (INIS)

    Yoshioka, Yasuo; Sasaki, Toshihiko; Kuramoto, Makoto.

    1985-01-01

    In the past X-ray stress analysis in which the effect of stress gradients was taken into account within the penetration depth of X-rays, three assumptions have been made; 1) the stress gradient is linear in respect to the depth from the specimen surface, 2) the penetration depth of X-ray is a function of Sin 2 PSI and 3) the strain measured by X-rays corresponds to the weighted average strain on the intensity of the diffracted X-rays. A problem, however, still remains on the assumption of the X-ray penetration depth. We sometimes observed noticiable errors in the stage of the numerical simulation and these errors depend on the combination of stress components in a stress tensor. In the present paper, we proposed a new X-ray multiaxial stress analysis without using the assumption of the X-ray penetration depth. This analysis is also applicable to both the iso-inclination method ( OHM -goniometer) and the side inclination method (PSI-goniometer). The weighted average strain by X-rays, 1 >(phi), is expressed as a 4th degree function of cosPSI for iso-inclination method and 3rd degree for side inclination method. By rearranging this function as a sum of average strain, ( 1 >(0 0 )+ 1 >(90 0 )), and difference of average strain, ( 1 >(0 0 )- 1 >(90 0 )), we can solve the stress components with sufficient accuracy by a least squares method. The validity of this method was proved through numerical simulations and experiments. (author)

  15. The reliability of child psychiatric diagnosis. A comparison among Danish child psychiatrists of traditional diagnoses and a multiaxial diagnostic system

    DEFF Research Database (Denmark)

    Skovgaard, A M; Isager, T; Jørgensen, O S

    1988-01-01

    The study was conducted to compare an experimental multiaxial diagnostic system (MAS) with traditional multicategorical diagnoses in child psychiatric work. Sixteen written case histories were circulated to 21 child psychiatrists, who made diagnoses independently of one another, using two different...

  16. Tests on creep and influence of creep on strength of concrete under multiaxial stresses

    International Nuclear Information System (INIS)

    Lanig, N.; Stoeckl, S.; Kupfer, H.

    1988-12-01

    Long-time tests of three-axially loaded, sealed cylindrical specimens d = 15 cm, h = 40 cm, were carried out. The 20-cm-cube strength of the concrete was app. 45 N/mm 2 . The creep stresses were chosen in the following ranges: 0,3 ≤ σ c /β c ≤ 2,1; 0 ≤ σ r /σ l ≤ 1,0. The creep coefficients obtained were clearly depending on the multi-axial stress conditions. The creep coefficients for a t = 2 years loading were reaching app. 1 for σ l /β c = 0,3 and app. 3 for σ l /β c = 2,1, when the test evaluation was based on the initial deformations meausred after 1 minute. For σ l /β c = 2,1 the creep coefficients obtained were about 4 times as large, proceeding form calculated elastic deformations. Further evaluations concerned the Young's modulus E, Poisson's ratio μ, the bulk modulus K and the shear modulus G. The preceding permanent load leads to an increase in the Young's modulus of the concrete in longitudinal direction of the specimen up to about 4 times the value of not preloaded comparative specimens. (orig.) [de

  17. Micro-vision servo control of a multi-axis alignment system for optical fiber assembly

    International Nuclear Information System (INIS)

    Chen, Weihai; Yu, Fei; Qu, Jianliang; Chen, Wenjie; Zhang, Jianbin

    2017-01-01

    This paper describes a novel optical fiber assembly system featuring a multi-axis alignment function based on micro-vision feedback control. It consists of an active parallel alignment mechanism, a passive compensation mechanism, a micro-gripper and a micro-vision servo control system. The active parallel alignment part is a parallelogram-based design with remote-center-of-motion (RCM) function to achieve precise rotation without fatal lateral motion. The passive mechanism, with five degrees of freedom (5-DOF), is used to implement passive compensation for multi-axis errors. A specially designed 1-DOF micro-gripper mounted onto the active parallel alignment platform is adopted to grasp and rotate the optical fiber. A micro-vision system equipped with two charge-coupled device (CCD) cameras is introduced to observe the small field of view and obtain multi-axis errors for servo feedback control. The two CCD cameras are installed in an orthogonal arrangement—thus the errors can be easily measured via the captured images. Meanwhile, a series of tracking and measurement algorithms based on specific features of the target objects are developed. Details of the force and displacement sensor information acquisition in the assembly experiment are also provided. An experiment demonstrates the validity of the proposed visual algorithm by achieving the task of eliminating errors and inserting an optical fiber to the U-groove accurately. (paper)

  18. Creep properties of phosphorus alloyed oxygen free copper under multiaxial stress state

    International Nuclear Information System (INIS)

    Rui Wu; Sandstroem, Rolf; Seitisleam, Facredin

    2009-10-01

    Phosphorus alloyed oxygen free copper (Cu-OFP) canisters are planned to be used for spent nuclear fuel in Sweden. The copper canisters will be subjected to creep under multiaxial stress states in the repository. Creep tests have therefore been carried out at 75 deg C using double notch specimens with notch acuities of 0.5, 2, 5, and 18.8, respectively. The creep lifetime for notched specimens is considerably longer than that for the smooth one at a given net section stress, indicating that the investigated Cu-OFP is notch insensitive (notch strengthening). The notch strengthening factor in time is, for instance, greater than 70 at 180 MPa for the bluntest notch (notch acuity = 0.5). The creep lifetime is notch acuity dependent. The sharper the notch, the longer the creep lifetime is. The creep deformation is to a significant extent concentrated to the region around the notches. Different deformation on the two notches is observed. Both axial and radial strains on the failed notch are several times larger than those on the unbroken one. Linear relation between the axial and the radial strains on the notches is found. Transgranular failure is predominant, independent of stress, rupture time, and notch acuity. Adjacent to fracture, elongated grains along the stress direction, separate pores and cavities are often visible. On the unbroken notch, fewer separate cavities and cracks are only seen intergranularly for the sharper notches (notch acuity > 2). To interpret the tests for the notched creep specimens, finite element computations have been performed. A fundamental model for primary and secondary creep without fitting parameters has been used as constitutive equation. The FEM-modelling could represent the creep strain versus time curves for the notched specimens in a satisfactory way. In these curves the strain on loading is included. From the FEM-computations a stationary creep stress could be assessed, which is close to the reference stress. For a given

  19. Adding dimension to cellular mechanotransduction: Advances in biomedical engineering of multiaxial cell-stretch systems and their application to cardiovascular biomechanics and mechano-signaling.

    Science.gov (United States)

    Friedrich, O; Schneidereit, D; Nikolaev, Y A; Nikolova-Krstevski, V; Schürmann, S; Wirth-Hücking, A; Merten, A L; Fatkin, D; Martinac, B

    2017-11-01

    Hollow organs (e.g. heart) experience pressure-induced mechanical wall stress sensed by molecular mechano-biosensors, including mechanosensitive ion channels, to translate into intracellular signaling. For direct mechanistic studies, stretch devices to apply defined extensions to cells adhered to elastomeric membranes have stimulated mechanotransduction research. However, most engineered systems only exploit unilateral cellular stretch. In addition, it is often taken for granted that stretch applied by hardware translates 1:1 to the cell membrane. However, the latter crucially depends on the tightness of the cell-substrate junction by focal adhesion complexes and is often not calibrated for. In the heart, (increased) hemodynamic volume/pressure load is associated with (increased) multiaxial wall tension, stretching individual cardiomyocytes in multiple directions. To adequately study cellular models of chronic organ distension on a cellular level, biomedical engineering faces challenges to implement multiaxial cell stretch systems that allow observing cell reactions to stretch during live-cell imaging, and to calibrate for hardware-to-cell membrane stretch translation. Here, we review mechanotransduction, cell stretch technologies from uni-to multiaxial designs in cardio-vascular research, and the importance of the stretch substrate-cell membrane junction. We also present new results using our IsoStretcher to demonstrate mechanosensitivity of Piezo1 in HEK293 cells and stretch-induced Ca 2+ entry in 3D-hydrogel-embedded cardiomyocytes. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Role of multiaxial stress state in the hydrogen-assisted rolling-contact fatigue in bearings for wind turbines

    Directory of Open Access Journals (Sweden)

    J. Toribio

    2015-07-01

    Full Text Available Offshore wind turbines often involve important engineering challenges such as the improvement of hydrogen embrittlement resistance of the turbine bearings. These elements frequently suffer the so-called phenomenon of hydrogen-assisted rolling-contact fatigue (HA-RCF as a consequence of the synergic action of the surrounding harsh environment (the lubricant supplying hydrogen to the material and the cyclic multiaxial stress state caused by in-service mechanical loading. Thus the complex phenomenon could be classified as hydrogen-assisted rolling-contact multiaxial fatigue (HA-RC-MF. This paper analyses, from the mechanical and the chemical points of view, the so-called ball-on-rod test, widely used to evaluate the hydrogen embrittlement susceptibility of turbine bearings. Both the stress-strain states and the steady-state hydrogen concentration distribution are studied, so that a better elucidation can be obtained of the potential fracture places where the hydrogen could be more harmful and, consequently, where the turbine bearings could fail during their life in service.

  1. Accuracy Improvement of Multi-Axis Systems Based on Laser Correction of Volumetric Geometric Errors

    Science.gov (United States)

    Teleshevsky, V. I.; Sokolov, V. A.; Pimushkin, Ya I.

    2018-04-01

    The article describes a volumetric geometric errors correction method for CNC- controlled multi-axis systems (machine-tools, CMMs etc.). The Kalman’s concept of “Control and Observation” is used. A versatile multi-function laser interferometer is used as Observer in order to measure machine’s error functions. A systematic error map of machine’s workspace is produced based on error functions measurements. The error map results into error correction strategy. The article proposes a new method of error correction strategy forming. The method is based on error distribution within machine’s workspace and a CNC-program postprocessor. The postprocessor provides minimal error values within maximal workspace zone. The results are confirmed by error correction of precision CNC machine-tools.

  2. Multi-axial correction system in the treatment of radial club hand.

    Science.gov (United States)

    Bhat, Suneel B; Kamath, Atul F; Sehgal, Kriti; Horn, B David; Hosalkar, Harish S

    2009-12-01

    Radial club hand is a well-recognized congenital malformation characterized by hypoplasia of bone and soft tissue on the radial aspect of the forearm and hand. The modalities of treatment have traditionally varied from stretching casts with soft-tissue procedures to the use of multiple corrective osteotomies. These osteotomies can be stabilized by a variety of methods, including external fixators that allow the possibility of gradual distraction with neohistiogenesis. This current study outlines the usage of one such device (multi-axial correction system [MAC]) in the management of deformity associated with severe radial club hand. Three consecutive cases of unilateral or bilateral severe (Bayne type IV) congenital radial club hand were corrected using MAC fixation in the last 5 years. This is a retrospective review of all three cases. Data parameters included: patient demographics, presentation findings, degree of deformity, amount of correction/lengthening, length of procedure, length of treatment, and associated complications. The surgical technique is described in detail for the benefit of the readership. The three patients with severe congenital radial club hand had a total of four limb involvements that underwent correction using osteotomies and usage of the MAC device for external fixation. All three patients underwent successful correction of deformity with the restoration of alignment, lengthening of forearm for improvement of function, and stabilization of the wrist (mean duration, mean lengthening, mean time to consolidation). The MAC system was well tolerated in all patients and associated complications were limited. The MAC fixator seems to be a good alternative modality of stabilization and correction for severe congenital radial club hand deformities. Its usage is fairly simple and it provides the ease of application of a mono-lateral fixator with far superior three-dimensional control, like the circular external fixator. We recommend that

  3. Mathematical formulations of failure criteria for the case of multiaxial stress

    International Nuclear Information System (INIS)

    Peiter, A.

    1979-01-01

    Assured characteristic values of stress analyses cannot be simply applied to new kinds of stresses. In order to avoid excessive safety specifications and overdimensioning, a functional relationship between the various operational stresses has to be established. This will also facilitate an optimum materials evaluation. Shape and position of incipient cracks or crack propagations, appearance and surface of fractures as well as operating parameters serve as a basis for the hypotheses to be set up in order to give a phenomenological description of verified relations and of those assumed to be involved in a process. (orig.) [de

  4. Multiaxial creep-fatigue rules

    International Nuclear Information System (INIS)

    Spindler, M.W.; Hales, R.; Ainsworth, R.A.

    1997-01-01

    Within the UK, a comprehensive procedure, called R5, is used to assess the high temperature response of structures. One part of R5 deals with creep-fatigue initiation, and in this paper we describe developments in this part of R5 to cover multiaxial stress states. To assess creep-fatigue, damage is written as the linear sum of fatigue and creep components. Fatigue is assessed using Miner's law with the total endurance split into initiation and growth cycles. Initiation is assessed by entering the curve of initiation cycles vs strain range using a Tresca equivalent strain range. Growth is assessed by entering the curve of growth cycles vs strain range using a Rankine equivalent strain range. The number of allowable cycles is obtained by summing the initiation and growth cycles. In this way the problem of defining an equivalent strain range applicable over a range of endurance is avoided. Creep damage is calculated using ductility exhaustion methods. In this paper we address two aspects; first, the nature of stress relaxation and, hence, accumulated creep strain in multiaxial stress fields; secondly, the effect of multiaxial stress on creep ductility. The effect of multiaxial stress state on creep ductility has been examined using experimental data and mechanistic models. Good agreement is demonstrated between an empirical description of test data and a cavity growth model, provided a simple nucleation criterion is included. A simple scaling factor is applied to uniaxial creep ductility, defined as a function of stress state. The factor is independent of the cavity growth mechanisms and yields a value of equivalent strain which can be conveniently used in determining creep damage by ductility exhaustion. (author). 14 refs, 4 figs

  5. Random accumulated damage evaluation under multiaxial fatigue loading conditions

    Directory of Open Access Journals (Sweden)

    V. Anes

    2015-07-01

    Full Text Available Multiaxial fatigue is a very important physical phenomenon to take into account in several mechanical components; its study is of utmost importance to avoid unexpected failure of equipment, vehicles or structures. Among several fatigue characterization tools, a correct definition of a damage parameter and a load cycle counting method under multiaxial loading conditions show to be crucial to estimate multiaxial fatigue life. In this paper, the SSF equivalent stress and the virtual cycle counting method are presented and discussed, regarding their physical foundations and their capability to characterize multiaxial fatigue damage under complex loading blocks. Moreover, it is presented their applicability to evaluate random fatigue damage.

  6. Life estimation of low-cycle fatigue of pipe elbows. Proposed criteria of low-cycle fatigue life under the multi-axial stress field

    International Nuclear Information System (INIS)

    Ando, Kotoji; Takahashi, Koji; Matsuo, Kazuya; Urabe, Yoshio

    2013-01-01

    Pipe elbows were important parts frequently used in the pipelines of nuclear power, thermal power and chemical plants, and their integrity needed to be assured under seismic loads and thermal stresses considering local wall thinning or complex stress distribution due to special configuration different from straight pipe. This article investigated in details elastic-plastic stress-strain state of pipe elbow using finite element analysis and clarified there existed high bi-axial stress field at side inner surface of pipe elbow axial cracks initiated. Bi-axial stress factor was around 0.6 for sound elbow and up to 0.95 for local wall thinning at crown. Fracture strain of 1.15 was reduced to around 0.15 for bi-axial stress factor from 0.6 to 0.9. Normalized fatigue life for bi-axial stress field (0.6 - 0.8) was largely reduced to around 15, 19 and 10% of fatigue life of uni-axial state dependent on material strength level. Proposed revised universal slopes taking account of multi-axial stress factor could explain qualitatively effects of strain range, internal pressure and ratchet strain (pre-strain) on low-cycle fatigue life of pipe elbow. (T. Tanaka)

  7. Multiaxial low cycle fatigue life under non-proportional loading

    International Nuclear Information System (INIS)

    Itoh, Takamoto; Sakane, Masao; Ohsuga, Kazuki

    2013-01-01

    A simple and clear method of evaluating stress and strain ranges under non-proportional multiaxial loading where principal directions of stress and strain are changed during a cycle is needed for assessing multiaxial fatigue. This paper proposes a simple method of determining the principal stress and strain ranges and the severity of non-proportional loading with defining the rotation angles of the maximum principal stress and strain in a three dimensional stress and strain space. This study also discusses properties of multiaxial low cycle fatigue lives for various materials fatigued under non-proportional loadings and shows an applicability of a parameter proposed by author for multiaxial low cycle fatigue life evaluation

  8. A methodology to obtain strain indicators under deep drawing multiaxial stresses. Application to DC-05 electro galvanized steel (UNE in ISO 10130)

    International Nuclear Information System (INIS)

    Miguel, V.; Catalayud, A.; Ferrer, C.

    2007-01-01

    In this work a methodology to investigate deep drawing quality steel sheets deformation tendency under multiaxial deep drawing stresses has been proposed. the method consists in assaying a sheet in a wedge die in order to order to introduce a pure shear estate in the material 0 degree centigree, 45 degree centigree and 90 degree centigree rolling directions are selected in the assays, and transversal strain is the variable considered in them. a strain coefficient 0/% has been defined in order to evaluate thickness variations in the test. almost no changes in thickness have been registered and this indicates that strain carried out in the test is similar to that taking place in deep drawing. The stress necessary for practice a certain plastic deformation is obtained too and a potential function between them is formulated. Indicators presented in this work are compared to anisotropy and strength coefficients obtained in normalized tensile tests. these results allow us to justify the steel behaviour in the cup deep drawing processes related to ear forming. (Author) 11 refs

  9. Development of multi-axis laser micromachining system suitable for machining non-linear contoured surfaces

    OpenAIRE

    Kerimoğlu, Serhat

    2016-01-01

    Cataloged from PDF version of article. Thesis (M.S.): Bilkent University, Department of Mechanical Engineering, İhsan Doğramacı Bilkent University, 2016. Includes bibliographical references (leaves 82-84). In recent years, studies on manufacturing systems have proved the importance of cooperation of positioning systems with laser cutting technology. The performance of the manufacturing system can be improved by utilizing both laser and positioning systems together. In thi...

  10. Design and Implementation of an Embedded Digital Throwing System Based on MEMS Multiaxial Accelerometer

    Directory of Open Access Journals (Sweden)

    Zhen GAO

    2010-04-01

    Full Text Available This paper presents a novel embedded digital throwing system for synchronously sensing the throwing force of shot-put athletes in real time. The three axes integrated accelerometer, as a crucial device in the force sensing system, can acquire the kinetics data along three orthogonal directions with reasonably high accuracy. The digital shot with almost the same size and weight as the standard shot for open female has been designed, fabricated and implemented. The mechanical structure, signal processing system, and human-machine interface are illuminated in detail. In this manner, the force sensing system serves as a powerful tool for coaches and sports scientists to make scientific researches on professional throwing techniques. It also provides an intuitive and reliable guidance for the throwing athletes to improve their skills.

  11. Determination of the critical plane and durability estimation for a multiaxial cyclic loading

    Science.gov (United States)

    Burago, N. G.; Nikitin, A. D.; Nikitin, I. S.; Yakushev, V. L.

    2018-03-01

    An analytical procedure is proposed to determine the critical plane orientation according to the Findley criterion for the multiaxial cyclic loading. The cases of in-phase and anti-phase cyclic loading are considered. Calculations of the stress state are carried out for the system of the gas turbine engine compressor disk and blades for flight loading cycles. The formulas obtained are used for estimations of the fatigue durability of this essential element of structure.

  12. An EM System With Dramatic Multi-Axis Transmitter and Tensor Gradiometer Receiver

    Science.gov (United States)

    2011-06-01

    Thus, the main difference between the spatial behavior of target anomalies measured with a magnetometer and those we measured with an EM system is in...current efforts include the development of tensor magnetic gradiometers based on triaxial fluxgate technology by the USGS (Snyder & Bracken, Development...Superconducting gradiometer/ Magnetometer Arrays and a Novel Signal Processing Technique. IEEE Trans. on Magnetics, MAG-11(2), 701-707. EM Tensor Gradiometer

  13. An EM System with Dynamic Multi-Axis Transmitter and Tensor Gradiometer Receiver

    Science.gov (United States)

    2011-06-01

    main difference between the spatial behavior of target anomalies measured with a magnetometer and those we measured with an EM system is in the nature...environmental and UXO applications, current efforts include the development of tensor magnetic gradiometers based on triaxial fluxgate technology by the USGS...Superconducting gradiometer/ Magnetometer Arrays and a Novel Signal Processing Technique. IEEE Trans. on Magnetics, MAG-11(2), 701-707. EM Tensor

  14. Pose-varied multi-axis optical finishing systems theory and process validation

    CERN Document Server

    Cheng, Haobo

    2015-01-01

    This book focuses on advanced optical finishing techniques and design for high-performance manufacturing systems. It provides numerous detailed examples of how advanced automation techniques have been applied to optical fabrication processes. The simulations, removal rate and accurate experimental results offer useful resources for engineering practice. Researchers, engineers and graduate students working in optical engineering and precision manufacture engineering will benefit from this book.

  15. A multi-axis electrothermal micromirror for a miniaturized OCT system

    KAUST Repository

    Izhar, U.

    2011-06-01

    We report on the development of a low power thermally actuated bi-axis SOI micromirror that is capable of performing angular and vertical scans for optical coherence tomography (OCT) applications. The device consists of a mirror with an aluminum coating over a 3 μm thick single crystal silicon base, aluminum/polysilicon electrothermal actuators with embedded heaters and polysilicon flexural connectors. In scanning mode, this mirror can satisfy our target specification of 5° angle at the low power of 1.7 mW with a temperature increase of 16.5 °C ± 7 °C from ambient in the actuator. Furthermore, a maximum angle of 32° has been achieved at 12 mW. In piston mode, it can reach vertical displacements of up to 131 μm at 12 mW with the temperature increase of 16.5 °C ± 7 °C from ambient in the actuator. The scanning speed for the mirror has been measured and the time response of the mirror is found to be 100 ms. The curvature of the mirror is found to be 2.4 mm ± 0.26 mm with a roughness of 100 nm ± 20 nm. Due to low driving power and moderate temperatures developed during its operation, this device can potentially be integrated with broadband light source, photodetector and interferometery system, to form a fully integrated OCT system on GaAs substrate. © 2011 Elsevier B.V. All rights reserved.

  16. Material laws for room temperature and high temperature, automatic adaptation to experimental data sets and applications to components under multiaxial stress; Stoffgesetze fuer Raum- und Hochtemperatur, automatisierte Anpassung an experimentelle Datensaetze und Anwendungen auf mehrachsig belastete Komponenten

    Energy Technology Data Exchange (ETDEWEB)

    Mohrmann, R.

    1998-12-01

    Models of materials mechanics were applied and improved, and a universal method for adapting the model parameters was developed. Measurements of several steels were processed by this method. The efficiency of the models and method was established by a comparison with measurements of components under multiaxial stress and components with FEA predictions. [German] Im Rahmen dieser Arbeit wurden werkstoffmechanische Modelle angewendet und weiterentwickelt. Fuer diese Modelle wurde eine universelle Methode zur Anpassung der Modellparameter entwickelt. Es wurden Messergebnisse verschiedener Stahlwerkstoffe mit dieser Methode bearbeitet. Die Leistungsfaehigkeit der untersuchten Modelle bzw. der entwickelten Methode wurde durch den Vergleich von Messergebnissen mehrachsig belasteter Komponenten bzw. Bauteilen mit Finite-Element Vorhersagen nachgewiesen. (orig.)

  17. The effect of a multi-axis suspension on whole body vibration exposures and physical stress in the neck and low back in agricultural tractor applications.

    Science.gov (United States)

    Kim, Jeong Ho; Dennerlein, Jack T; Johnson, Peter W

    2018-04-01

    Whole body vibration (WBV) exposures are often predominant in the fore-aft (x) or lateral (y) axis among off-road agricultural vehicles. However, as the current industry standard seats are designed to reduce mainly vertical (z) axis WBV exposures, they may be less effective in reducing drivers' exposure to multi-axial WBV. Therefore, this laboratory-based study aimed to determine the differences between a single-axial (vertical) and multi-axial (vertical + lateral) suspension seat in reducing WBV exposures, head acceleration, self-reported discomfort, and muscle activity (electromyography) of the major muscle of the low back, neck and shoulders. The results showed that the multi-axial suspension seat had significantly lower WBV exposures compared to the single-axial suspension seats (p' suspension seat had lower head acceleration and muscle activity of the neck, shoulder, and low back compared to the single-axial suspension seat; some but not all of the differences were statistically significant. These results indicate that the multi-axial suspension seat may reduce the lateral WBV exposures and associated muscular loading in the neck and low back in agricultural vehicle operators. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Prediction of multiaxial fatigue life for notched specimens of titanium alloy TC4

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Z. R.; Li, Z. X. [Southeast University, Nanjing (China); Hu, X. T.; Song, Y. D. [Nanjing University, Nanjing (China)

    2016-05-15

    Both the proportional and nonproportional multiaxial fatigue tests were conducted on two kinds of notched specimens of titanium alloy TC4. The multiaxial fatigue critical area of notched specimen is considered as the location experiencing the maximum damage. It is unsatisfactory to predict the multiaxial fatigue life with the local stress and strain in the fatigue critical area. The critical distance concepts are employed in the multiaxial life prediction method for notched specimens. The proposed method was checked by the test data of TC4 notched specimens. The prediction results are almost within a factor of three scatter band of the test results.

  19. On the impact of multi-axial stress states on trailing edge bondlines in wind turbine rotor blades

    OpenAIRE

    Castelos, Pablo Noever; Balzani, Claudio

    2016-01-01

    For a reliable design of wind turbine systems all of their components have to be designed to withstand the loads appearing in the turbine's lifetime. When performed in an integral manner this is called systems engineering, and is exceptionally important for components that have an impact on the entire wind turbine system, such as the rotor blade. Bondlines are crucial subcomponents of rotor blades, but they are not much recognized in the wind energy research community. However, a bondline fai...

  20. Multiaxial fatigue of aluminium friction stir welded joints: preliminary results

    Directory of Open Access Journals (Sweden)

    D. G. Hattingh

    2015-07-01

    Full Text Available The aim of the present research is to check the accuracy of the Modified Wöhler Curve Method (MWCM in estimating the fatigue strength of friction stir (FS welded tubular joints of Al 6082-T6 subjected to in-phase and out-of-phase multiaxial fatigue loading. The welded samples being investigated were manufactured by equipping an MTS I-STIR process development system with a retracting tool that was specifically designed and optimised for this purpose. These specimens were tested under proportional and non-proportional tension and torsion, the effect of non-zero mean stresses being also investigated. The validation exercise carried out by using the generated experimental results allowed us to prove that the MWCM (applied in terms of nominal stresses is highly accurate in predicting the fatigue strength of the tested FS welded joints, its usage resulting in estimates falling with the uniaxial and torsional calibration scatter bands.

  1. Multi-axial response of idealized cermets

    International Nuclear Information System (INIS)

    Pickering, E.G.; Bele, E.; Deshpande, V.S.

    2016-01-01

    The yield response of two idealized cermets comprising mono and bi-disperse steel spheres in a Sn/Pb solder matrix has been investigated for a range of axisymmetric stress states. Proportional stress path experiments are reported, from which are extracted the initial yield surfaces and their evolution with increasing plastic strain. The initial yield strength is nearly independent of the hydrostatic pressure but the strain hardening rate increases with stress triaxiality up to a critical value. For higher triaxialities, the responses are independent of hydrostatic pressure. Multi-axial measurements along with X-ray tomography were used to demonstrate that the deformation of these idealized cermets occurs by two competing mechanisms: (i) a granular flow mechanism that operates at low levels of triaxiality, where volumetric dilation occurs under compressive stress states, and (ii) a plastically incompressible mechanism that operates at high stress triaxialities. A phenomenological viscoplastic constitutive model that incorporates both deformation mechanisms is presented. While such multi-axial measurements are difficult for commercial cermets with yield strengths on the order of a few GPa, the form of their constitutive relation is expected to be similar to that of the idealized cermets presented here.

  2. Creep-fatigue damage under multiaxial conditions

    International Nuclear Information System (INIS)

    Lobitz, D.W.; Nickell, R.E.

    1977-02-01

    ASME Code rules for design against creep-fatigue damage for Class 1 nuclear components operating at elevated temperatures are currently being studied by ASME working groups and task forces with a view toward major modification. In addition, the design rules being developed for Class 2 and Class 3 components would be affected by any major modifications of Class 1 Rules. The report represents an attempt to evaluate the differences between two competing procedures--linear damage summation and strainrange partitioning--for multiaxial stress conditions. A modified version of strainrange partitioning is also developed to alleviate some limitations on nonproportional loading

  3. Microstructural study of multiaxial low cycle fatigue

    Directory of Open Access Journals (Sweden)

    Masao Sakane

    2015-07-01

    Full Text Available This paper discusses the relationship between the stress response and the microstructure under tension-torsion multiaxial proportional and nonproportional loadings. Firstly, this paper discusses the material dependency of additional hardening of FCC materials in relation with the stacking fault energy of the materials. The FCC materials studied were Type 304 stainless steel, pure copper, pure nickel, pure aluminum and 6061 aluminum alloy. The material with lower stacking fault energy showed stronger additional hardening, which was discussed in relation with slip morphology and dislocation structures. This paper, next, discusses dislocation structures of Type 304 stainless steel under proportional and nonproportional loadings at high temperature. The relationship between the microstructure and the hardening behavior whether isotropic or anisotropic was discussed. The re-arrangeability of dislocation structure was discussed in loading mode change tests. Microstructures of the steel was discussed in more extensively programmed multiaxial low cycle fatigue tests at room temperature, where three microstructures, dislocation bundle, stacking fault and cells, which were discussed in relation with the stress response. Finally, temperature dependence of the microstructure was discussed under proportional and nonproportional loadings, by comparing the microstructures observed at room and high temperatures.

  4. Fatigue life assessment under multiaxial variable amplitude loading

    International Nuclear Information System (INIS)

    Morilhat, P.; Kenmeugne, B.; Vidal-Salle, E.; Robert, J.L.

    1996-06-01

    A variable amplitude multiaxial fatigue life prediction method is presented in this paper. It is based on a stress as input data are the stress tensor histories which may be calculated by FEM analysis or measured directly on the structure during the service loading. The different steps of he method are first presented then its experimental validation is realized for log and finite fatigue lives through biaxial variable amplitude loading tests using cruciform steel samples. (authors). 9 refs., 7 figs

  5. Microcrack propagation under multiaxial loading - experiment and simulation

    International Nuclear Information System (INIS)

    Poetter, K.; Suhartono, A.; Yousefi, F.; Zenner, H.; Duewel, V.; Schram, A.

    2000-01-01

    The accuracy of lifetime prediction for technical components subjected to cyclic loading is still not satisfying. One essential reason for the deviation between the results of the lifetime calculation and experimental results is that it is not yet possible to generate a model capable to describe the microstructural damage process which occurs in the tested material and to integrate this model in the calculation. All of the present research results recognize that the growth of microcracks is significantly influenced by the microstructure of the material. In order to take into account the influence of the microstructure on the damage process a simulation model is suggested in this paper which considers the local stress state in addition to the random nature of the material structure in the form of grain boundaries and slip systems. The results generated by means of the simulation model are compared and verified with those experiences obtained from multiaxial fatigue testing of the investigated aluminum material. For this purpose the surfaces of the tested specimens are carefully observed to discover and analyze microcracks which are classified according to their number, length, and orientation. Moreover the mechanisms of crack initiation and propagation are major points of interest for the comparison of theoretical and experimental results. The developed computer software is suitable to simulate the microcrack initiation, the propagation and coalescence of microcracks as well as the transition of stage I cracks to stage II cracks for uniaxial and multiaxial loading. Results obtained from the simulation model could be verified with the experiment. The future aim to be emphasized is the utilization of the parameter investigations carried out with the computer simulation model in order to improve the lifetime prediction. (orig.)

  6. Influence of multiaxial preloading on the strength of concrete

    International Nuclear Information System (INIS)

    Linse, D.

    1975-01-01

    In a preliminary study about the influence of the loading direction discs of 20/20/5 cm were loaded at different stress-rates in one direction, then unloaded and loaded up to failure again. Two series of each about 15 specimens were tested: the first series was reloaded in the same direction as it was loaded before. If the preloading was not greater than about 90% of the original short-term uniaxial strength βsub(p), one could achieve in the second loading a higher strength than the strength βsub(p). The second series was reloaded normal to the direction of preloading. By an other series of about 50 specimens the influence of triaxial preloading on the uniaxial strength of concrete was tested. Cubes of 10cm were loaded by brush bearing platens up to a stress which was maximally three times higher than the uniaxial short-term strength βsub(p), then unloaded and tested again under uniaxial compression. The achieved ultimate strength of the cubes at the second loading was obviously dependent upon the stress-state and the stress-rate of the preloading. Multiaxial preloading which is far below the ultimate multiaxial strength can considerably defect the remaining strength of concrete. The decrease in strength was defined by the reduction of the uniaxial strength. It can be assumed that the remaining multiaxial strength is reduced at least to the same rate. Further tests are planned

  7. Multiaxial elastoplastic cyclic loading of austenitic 316L steel

    Czech Academy of Sciences Publication Activity Database

    Mazánová, Veronika; Polák, Jaroslav; Škorík, Viktor; Kruml, Tomáš

    2017-01-01

    Roč. 11, č. 40 (2017), s. 162-169 ISSN 1971-8993 R&D Projects: GA ČR(CZ) GA13-23652S; GA MŠk LM2015069; GA MŠk(CZ) LQ1601; GA ČR GA15-08826S Institutional support: RVO:68081723 Keywords : 316L steel * Crack initiation * Cyclic stress-strain curve * Multiaxial cyclic loading Subject RIV: JL - Materials Fatigue, Friction Mechanics OBOR OECD: Audio engineering, reliability analysis

  8. Uniaxial and Multiaxial Creep Testing of Copper

    International Nuclear Information System (INIS)

    Auerkari, Pertti; Holmstroem, Stefan; Veivo, Juha; Salonen, Jorma; Nenonen, Pertti; Laukkanen, Anssi

    2003-12-01

    Multiaxial (compact tension, CT) creep testing has been performed for copper with 79 ppm phosphorus and 60 ppm oxygen. The test load levels were selected according to results from preceding uniaxial creep testing and FE analysis of the CT specimens. Interrupted testing was used for metallographic inspection of the specimens for creep damage. After 7,900 h and 10,300 h of testing at 150 deg C and 46 MPa (reference stress), inspected CT specimens showed cavity indications with a low maximum density ( 2 ) and a typical maximum dimension of less than about 1 μm near the notch tip. From previous experience on creep cavitation damage, the expected minimum life to crack initiation at the notch tip would be at least 40,000 hours, but could be considerably longer because the cavity indications are suspected to originate at least partly from precipitates in specimen preparation. The interrupted testing of CT specimens also showed a 'segregation zone' along some grain boundaries, mainly near the notch tip. This zone appears to contain more P and O than the surrounding matrix, but less than the narrow grain boundary films that are already present in the as-new material. The zone is readily etched and shows a relatively sharp edge towards the matrix without an obvious phase boundary. Using converted multiaxial (CT) testing results, the predicted isothermal uniaxial creep life at 150 deg C/46 MPa is about 1,900 years. The corresponding creep life directly predicted from uniaxial data is 3,100 years, when estimated from a parametric best fit expression according to PD6605. Although the two results are satisfactorily within a factor of two in time, the uncertainties in the extended extrapolations remain large. Further testing is recommended, with at least two creep enhancing factors present. Such testing could include notched creep testing at 120-180 deg C in a corrosive environment, and notched model vessel creep testing at elevated pressure. It is also recommended that longer

  9. Multi-Axis Independent Electromechanical Load Control for Docking System Actuation Development and Verification Using dSPACE

    Science.gov (United States)

    Oesch, Christopher; Dick, Brandon; Rupp, Timothy

    2015-01-01

    The development of highly complex and advanced actuation systems to meet customer demands has accelerated as the use of real-time testing technology expands into multiple markets at Moog. Systems developed for the autonomous docking of human rated spacecraft to the International Space Station (ISS), envelope multi-operational characteristics which place unique constraints on an actuation system. Real-time testing hardware has been used as a platform for incremental testing and development for the linear actuation system which controls initial capture and docking for vehicles visiting the ISS. This presentation will outline the role of dSPACE hardware as a platform for rapid control-algorithm prototyping as well as an Electromechanical Actuator (EMA) system dynamic loading simulator, both conducted at Moog to develop the safety critical Linear Actuator System (LAS) of the NASA Docking System (NDS).

  10. Evaluation and visualization of multiaxial fatigue behavior under random non-proportional loading condition

    Directory of Open Access Journals (Sweden)

    Takahiro Morishita

    2017-07-01

    Full Text Available In cyclic multiaxial stress/strain condition under nonproportional loading in which principal direction of stress/strain are changed in a cycle, it becomes difficult to analyze stress/strain ranges because of complexity of multiaxial stress/strain states depending on time in cycles. In order to evaluate stress/strain simply and suitably under non-proportional loading, Itoh and Sakane have proposed a method called as IS-method and a strain parameter for life evaluation under non-proportional loading NP. In the method, 6-components of stress/strain are converted to an equivalent stress/strain indicating the amplitude and the direction of principal stress/strain as a function of time as well as an intensity of loading nonproportionality fNP. Based on IS-method, the authors also have developed a tool which enables to analyze multiaxial stress/strain condition with the nonproportionality of loading history and evaluate failure life under nonproportional multiaxial loading. The tool indicates the analyzed results on monitor and users can understand visually not only variation of the stress/strain conditions but also non-proportionality during the cycle, which helps the design of material strength.

  11. Safety assessment of reactor components under complex multiaxial cyclic loading. Final report; Sicherheitsbewertung kerntechnischer Komponenten bei komplexer, mehrachsiger Schwingbeanspruchung. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Fesich, Thomas M.; Herter, Karl-Heinz; Schuler, Xaver

    2012-12-15

    Objective of the project was the experimental assurance of investigations on the theoretical basis of multiaxial fatigue loading. The review of the applicability of existing hypotheses, as well as the extension of the corresponding data base was carried out by experimental studies in fatigue tests under complex multiaxial loading for a ferritic and austenitic material. To investigate the influence of complex multiaxial stress conditions on the fatigue behavior, in this project notched cylindrical specimens were examined under alternating tensile/pressure loading and alternating torsional loading. Through the notch in the notched section inhomogeneous, multiaxial stress states are generated. By uniaxial alternating tests on unnotched specimens and a further series of tests on unnotched specimens under alternating torsional loading an evaluation of the impact and influence of the notch of stress on fatigue behavior was possible. A series of experiments with superimposition of alternating torsional and alternating tensile/pressure loading permits verification of the effect of phase-shifted stress and rotating principal coordinate system. All experiments were performed at room temperature. As part of the research project, the experimental results with the ferritic and austenitic materials were evaluated in terms of material behavior (hardening or softening) under cyclic loading. These were to uniaxial alternating tensile/pressure tests, alternating torsional tests (unnotched cylindrical specimens), alternating tensile/pressure tests on notched cylindrical specimens, alternating torsional tests on notched cylindrical specimens, alternating tensiontorsion tests with complex proportional stresses on unnotched cylindrical specimens (superimposition of normal and shear stress components), as well as alternating tension-torsion tests with complex non-proportional strain on unnotched cylindrical specimens (superimposition of normal and shear stress components with 90 phase

  12. A New Multiaxial High-Cycle Fatigue Criterion Based on the Critical Plane for Ductile and Brittle Materials

    Science.gov (United States)

    Wang, Cong; Shang, De-Guang; Wang, Xiao-Wei

    2015-02-01

    An improved high-cycle multiaxial fatigue criterion based on the critical plane was proposed in this paper. The critical plane was defined as the plane of maximum shear stress (MSS) in the proposed multiaxial fatigue criterion, which is different from the traditional critical plane based on the MSS amplitude. The proposed criterion was extended as a fatigue life prediction model that can be applicable for ductile and brittle materials. The fatigue life prediction model based on the proposed high-cycle multiaxial fatigue criterion was validated with experimental results obtained from the test of 7075-T651 aluminum alloy and some references.

  13. Stress Erythropoiesis Model Systems.

    Science.gov (United States)

    Bennett, Laura F; Liao, Chang; Paulson, Robert F

    2018-01-01

    Bone marrow steady-state erythropoiesis maintains erythroid homeostasis throughout life. This process constantly generates new erythrocytes to replace the senescent erythrocytes that are removed by macrophages in the spleen. In contrast, anemic or hypoxic stress induces a physiological response designed to increase oxygen delivery to the tissues. Stress erythropoiesis is a key component of this response. It is best understood in mice where it is extramedullary occurring in the adult spleen and liver and in the fetal liver during development. Stress erythropoiesis utilizes progenitor cells and signals that are distinct from bone marrow steady-state erythropoiesis. Because of that observation many genes may play a role in stress erythropoiesis despite having no effect on steady-state erythropoiesis. In this chapter, we will discuss in vivo and in vitro techniques to study stress erythropoiesis in mice and how the in vitro culture system can be extended to study human stress erythropoiesis.

  14. Crack mode and life of Ti-6Al-4V under multiaxial low cycle fatigue

    Directory of Open Access Journals (Sweden)

    Takamoto Itoh

    2015-10-01

    Full Text Available This paper studies multiaxial low cycle fatigue crack mode and failure life of Ti-6Al-4V. Stress controlled fatigue tests were carried out using a hollow cylinder specimen under multiaxial loadings of λ=0, 0.4, 0.5 and 1 of which stress ratio R=0 at room temperature. λ is a principal stress ratio and is defined as λ=II/I, where I and II are principal stresses of which absolute values take the largest and middle ones, respectively. Here, the test at λ=0 is a uniaxial loading test and that at λ=1 an equi-biaxial loading test. A testing machine employed is a newly developed multiaxial fatigue testing machine which can apply push-pull and reversed torsion loadings with inner pressure onto the hollow cylinder specimen. Based on the obtained results, this study discusses evaluation of the biaxial low cycle fatigue life and crack mode. Failure life is reduced with increasing λ induced by cyclic ratcheting. The crack mode is affected by the surface condition of cut-machining and the failure life depends on the crack mode in the multiaxial loading largely.

  15. Validation of a new multiaxial criteria for creep-fatigue damage evaluation

    International Nuclear Information System (INIS)

    Cabrillat, M.T.; Martin, P.

    1989-01-01

    For many years, design codes evaluated creep damage using the Von Mises criterion to take account of multiaxiality of stresses. However, recent studies have confirmed that the Von Mises criterion is overconservative for nonuniaxial stress state. Various criteria have been put forward to take account of the real stress state. This paper describes a criterion which was introduced in 1987 and the various studies which led to its adoption

  16. Creating a Multi-axis Machining Postprocessor

    Directory of Open Access Journals (Sweden)

    Petr Vavruška

    2012-01-01

    Full Text Available This paper focuses on the postprocessor creation process. When using standard commercially available postprocessors it is often very difficult to modify its internal source code, and it is a very complex process, in many cases even impossible, to implement the newly-developed functions. It is therefore very important to have a method for creating a postprocessor for any CAM system, which allows CL data (Cutter Location data to be generated to a separate text file. The goal of our work is to verify the proposed method for creating a postprocessor. Postprocessor functions for multi-axis machiningare dealt with in this work. A file with CL data must be translated by the postprocessor into an NC program that has been customized for a specific production machine and its control system. The postprocessor is therefore verified by applications for machining free-form surfaces of complex parts, and by executing the NC programs that are generated on real machine tools. This is also presented here.

  17. Damage development - effects of multiaxial loads on creep pore formation and fatigue damage in typical power plant steels. Final report

    International Nuclear Information System (INIS)

    Lenk, P.; Proft, D.; Kussmaul, A.; Fischer, R.

    2000-01-01

    The influence of multiaxial stress on creep pore formation in the steels 14MoV6-3 10CrMo9-10 and X10CrMoVNb9-1 was investigated on the basis of internal pressure experiments on smooth and notched hollow cylinders. In some cases, additional axial forces were applied in order to reproduce component-relevant multiaxial stresses. Local elongation during loading was investigated and analyzed using applied HT-DMS. When different strain levels had been reached, the samples were removed, analyzed, and characterized with regard to different damage parameters. It was found that no interdependence between the surface damage pattern and the deep damage pattern can be derived across the wall thickness if no information on the load state is available. Parallel to the experiments, inelastic FEA were carried out using the ABAQUS program system. The creep law of Graham and Walles was used for calculating flow and creep via a user-defined subroutine CREEP. The parameters of the creep law could be identified by adaptation to monoaxial creep tests [de

  18. Remaining life case history studies for high energy piping systems using equivalent stress

    International Nuclear Information System (INIS)

    Cohn, M.J.

    1987-01-01

    As the development of plant life extension for high energy piping systems is progressing, conventional piping system design methodologies are also being reevaluated. Traditional guidelines such as American National Standard Institute/American Society of Mechanical Engineers B31.1 (ANSI/ASME) were developed for plants having design lives in the 25- to 30-year regime based upon relatively short-term base metal creep data. These guidelines use a simplified approach for the piping analysis. Two types of stress criteria must be satisfied. The first type is longitudinal plus torsion stress checks for several types of loading conditions versus the material allowable stresses. The second type is an independent minimum wall thickness check which considers the hoop stress versus the material allowable stress. Seven case histories have been evaluated to estimate the minimum piping system creep life based on the current ANSI/ASME B31.1 finite element type of analysis, which is a traditional approach, versus a multiaxial stress state type of analysis. In nearly every case, the equivalent stress methodology predicted significantly higher stresses. Consequently, the equivalent stress methodology resulted in 11 to 96% lower time to rupture values as compared to the values predicted using ANSI/ASME B31.1 stresses

  19. Effects of multiaxial cyclic loading conditions on the evolution of porous defects

    Directory of Open Access Journals (Sweden)

    Mbiakop Armel

    2014-06-01

    Full Text Available Multiaxial loading conditions are one of the important parameters in estimating the lifetime of structure both in high and low cycle fatigue ([1 3]. In order to understand the coupling between the macroscopic multiaxial loading and the microscopic defects, we propose to investigate the evolution of an elasto-plastic porous material up to failure under low cycle fatigue conditions. The analysis is performed numerically, using finite elements, on a periodic 3D unit-cell under the assumption of finite strains and subjected to various stress triaxialities, translated as ratios between deviatoric, hydrostatic stress and Lode angles. The present discussion introduces several novel factors in the analysis: (i 3D geometry in cyclic loading (ii finite strains (iii free evolving void shape (iiii different hardening laws. That one of the important factors is the void shape and that its evolution during cyclic loading depends on its multiaxiality. Moreover, these factors will equally influence the apparent macroscopic hardening or softening of the material and the initiation of localized shear zones at the microscopic level. The Lode angle has a significant impact on the evolution of the aspect ratios and the ellipsoidicity of the pores, but has only a weak influence on the evolution of macroscopic variables such as the stress or the porosity. As a consequence, the results show that multiaxiality of the loading have an important on the evolution and growth of defects, pores in the present case problem, but are less important in the definition of the yield surface.

  20. Designing aluminium friction stir welded joints against multiaxial fatigue

    Directory of Open Access Journals (Sweden)

    L. Susmel

    2016-07-01

    Full Text Available The present paper investigates the accuracy of the Modified Wöhler Curve Method (MWCM in estimating multiaxial fatigue strength of aluminium friction stir (FS welded joints. Having developed a bespoke joining technology, circumferentially FS welded tubular specimens of Al 6082-T6 were tested under proportional and non-proportional tension and torsion, the effect of non-zero mean stresses being also investigated. The validation exercise carried out using the experimental results have demonstrated that the MWCM applied in terms of nominal stresses, notch stresses, and also the Point Method is accurate in predicting the fatigue lifetime of the tested FS welded joints, with its use resulting in life estimates that fall within the uniaxial and torsional calibration scatter bands.

  1. Multiaxial creep of tubes from Incoloy 800 H and Inconel 617 under static and cyclic loading conditions

    International Nuclear Information System (INIS)

    Penkalla, H.J.; Nickel, H.; Schubert, F.

    1989-01-01

    At temperatures above 800 0 C the material behaviour under mechanical load is determined by creep. The service of heat exchanging components leads to multiaxial loading conditions. For design and inelastic analysis of the component behaviour time dependent design values and suitable constitutive equations are necessary. The present report gives a survey of the approaches to describing creep under multiaxial loading. Norton's law and v. Mises' theory are applied. The load combinations of internal pressure, tensile and torsional stress are studied more closely, cyclic stress superposition in the tensile-pulsating range is discussed and cases of partial relaxation are examined. Experimental results are presented for the loading conditions discussed, and satisfactory agreement between theory and experiment has been found up to now for these results. Regarding lifetime determination under multiaxial creep load, a more precise analysis of creep damage is presented suggesting a suitable deviatoric stress for evaluation in the long-time range. (orig.)

  2. Multiaxial creep of fine grained 0.5Cr-0.5Mo-0.25V and coarse grained 1Cr-0.5Mo steels

    International Nuclear Information System (INIS)

    Browne, R.J.; Flewitt, P.E.J.; Lonsdale, D.

    1991-01-01

    To explore the multiaxial creep response of materials used for electrical power generating plant, two steels, a fine grained 0.5Cr-0.5Mo-0.25V steel in a normalised and tempered condition with high creep ductility and a coarse grained 1Cr-0.5Mo steel in a quenched and tempered condition with low uniaxial creep ductility, have been selected. A range of multiaxial stress testing techniques which span the stress states that would allow identification of any technique dependent variables has been used. The deformation and failure of the normalised and tempered 0.5Cr-0.5Mo-0.25V steel for a range of multiaxial test techniques and, therefore, stress states may be described by an equivalent stress criterion. The results from the multiaxial tests carried out on the fully bainitic 1Cr-0.5Mo steel show that the multiaxial stress rupture criterion (MSRC) varies with stress state; at high triaxiality (notch), it is controlled by the maximum principal stress, whereas at low triaxiality (shear) it is dependent on both maximum principal stress and equivalent stress. Furthermore, a simple description of stress state based on maximum principal and equivalent stress does not define this uniquely, since the MSRC derived from uniaxial and torsion testing does not describe the failure of notch, tube, or double shear tests. (author)

  3. Multiaxial fatigue criterion based on parameters from torsion and axial S-N curve

    Directory of Open Access Journals (Sweden)

    M. Margetin

    2016-07-01

    Full Text Available Multiaxial high cycle fatigue is a topic that concerns nearly all industrial domains. In recent years, a great deal of recommendations how to address problems with multiaxial fatigue life time estimation have been made and a huge progress in the field has been achieved. Until now, however, no universal criterion for multiaxial fatigue has been proposed. Addressing this situation, this paper offers a design of a new multiaxial criterion for high cycle fatigue. This criterion is based on critical plane search. Damage parameter consists of a combination of normal and shear stresses on a critical plane (which is a plane with maximal shear stress amplitude. Material parameters used in proposed criterion are obtained from torsion and axial S-N curves. Proposed criterion correctly calculates life time for boundary loading condition (pure torsion and pure axial loading. Application of proposed model is demonstrated on biaxial loading and the results are verified with testing program using specimens made from S355 steel. Fatigue material parameters for proposed criterion and multiple sets of data for different combination of axial and torsional loading have been obtained during the experiment.

  4. Multiaxial loading of large-diameter, thin-walled tube rock specimens

    International Nuclear Information System (INIS)

    Hecker, S.S.; Petrovic, J.J.

    1981-01-01

    A large-scale mechanical testing facility permits previously impossible thin-walled tube multiaxial loading experiments on rock materials. Constraints are removed regarding tube wall thickness in relation to rock microstructural features and tube diameter as well as test machine load capacity. Thin-walled tube studies clarify the influence of intermediate principal stress sigma 2 on rock fracture and help define a realistic rock fracture criterion for all multiaxial stressing situations. By comparing results of thin-walled and thick-walled tube fracture investigations, effects of stress gradients can be established. Finally, influence of stress path on rock fracture, an area largely ignored in current rock failure criteria, can be examined in detail using controlled loading changes as well as specimen prestrains

  5. Stress and disorders of the stress system.

    Science.gov (United States)

    Chrousos, George P

    2009-07-01

    All organisms must maintain a complex dynamic equilibrium, or homeostasis, which is constantly challenged by internal or external adverse forces termed stressors. Stress occurs when homeostasis is threatened or perceived to be so; homeostasis is re-established by various physiological and behavioral adaptive responses. Neuroendocrine hormones have major roles in the regulation of both basal homeostasis and responses to threats, and are involved in the pathogenesis of diseases characterized by dyshomeostasis or cacostasis. The stress response is mediated by the stress system, partly located in the central nervous system and partly in peripheral organs. The central, greatly interconnected effectors of this system include the hypothalamic hormones arginine vasopressin, corticotropin-releasing hormone and pro-opiomelanocortin-derived peptides, and the locus ceruleus and autonomic norepinephrine centers in the brainstem. Targets of these effectors include the executive and/or cognitive, reward and fear systems, the wake-sleep centers of the brain, the growth, reproductive and thyroid hormone axes, and the gastrointestinal, cardiorespiratory, metabolic, and immune systems. Optimal basal activity and responsiveness of the stress system is essential for a sense of well-being, successful performance of tasks, and appropriate social interactions. By contrast, excessive or inadequate basal activity and responsiveness of this system might impair development, growth and body composition, and lead to a host of behavioral and somatic pathological conditions.

  6. Comparison of two multiaxial fatigue models applied to dental implants

    Directory of Open Access Journals (Sweden)

    JM. Ayllon

    2015-07-01

    Full Text Available This paper presents two multiaxial fatigue life prediction models applied to a commercial dental implant. One model is called Variable Initiation Length Model and takes into account both the crack initiation and propagation phases. The second model combines the Theory of Critical Distance with a critical plane damage model to characterise the initiation and initial propagation of micro/meso cracks in the material. This paper discusses which material properties are necessary for the implementation of these models and how to obtain them in the laboratory from simple test specimens. It also describes the FE models developed for the stress/strain and stress intensity factor characterisation in the implant. The results of applying both life prediction models are compared with experimental results arising from the application of ISO-14801 standard to a commercial dental implant.

  7. Multiaxial fatigue strength of type 316 stainless steel under push–pull, reversed torsion, cyclic inner and outer pressure loading

    International Nuclear Information System (INIS)

    Morishita, Takahiro; Itoh, Takamoto; Bao, Zhenlong

    2016-01-01

    Multiaxial fatigue tests under non-proportional loading in which principal directions of stress and strain are changed in a cycle were carried out using a developed multiaxial fatigue testing machine which can load a push–pull and reversed torsion loading with cyclic inner and outer pressure. This paper presents the developed testing machine and experimental results under several multiaxial loading conditions including non-proportional loading. In strain control tests, the failure life is reduced in accordance with increasing inner pressure at each strain path. The failure life can be correlated by von Mises' equivalent stress amplitude relatively well independent of not only inner pressure but also loading path. In load control tests, the failure life is reduced largely by non-proportional loading but the influence of inner and outer pressure on the failure life is relative small.

  8. Multiaxial ratcheting behavior of zirconium alloy tubes under combined cyclic axial load and internal pressure

    Energy Technology Data Exchange (ETDEWEB)

    Chen, G.; Zhang, X. [School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 (China); Xu, D.K. [Environmental Corrosion Center, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Li, D.H. [Hunan Taohuajiang Nuclear Power Co., Ltd, Yiyang, 413000 (China); Chen, X. [School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 (China); Zhang, Z., E-mail: zhe.zhang@tju.edu.cn [School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 (China)

    2017-06-15

    In this study, a series of uniaxial and multiaxial ratcheting tests were conducted at room temperature on zirconium alloy tubes. The experimental results showed that for uniaxial symmetrical cyclic test, the axial ratcheting strain ɛ{sub x} did not accumulate obviously in initial stage, but gradually increased up to 1% with increasing stress amplitude σ{sub xa}. For multiaxial ratcheting tests, the zirconium alloy tube was highly sensitive to both the axial stress amplitude σ{sub xa} and the internal pressure p{sub i}. The hoop ratcheting strain ɛ{sub θ} increased continuously with the increase of axial stress amplitude, whereas the evolution of axial ratcheting strain ɛ{sub x} was related to the axial stress amplitude. The internal pressure restricted the ratcheting accumulation in the axial direction, but promoted the hoop ratcheting strain on the contrary. The prior loading history greatly restrained the ratcheting behavior of subsequent cycling with a small internal pressure. - Highlights: •Uniaxial and multiaxial ratcheting behavior of the zirconium alloy tubes are investigated at room temperature. •The ratcheting depends greatly on the stress amplitude or internal pressure. •The interaction between the axial and hoop ratcheting mechanisms is greatly dependent on the internal pressure level. •The ratcheting is influenced significantly by the loading history of internal pressure.

  9. Multiaxial ratcheting behavior of zirconium alloy tubes under combined cyclic axial load and internal pressure

    International Nuclear Information System (INIS)

    Chen, G.; Zhang, X.; Xu, D.K.; Li, D.H.; Chen, X.; Zhang, Z.

    2017-01-01

    In this study, a series of uniaxial and multiaxial ratcheting tests were conducted at room temperature on zirconium alloy tubes. The experimental results showed that for uniaxial symmetrical cyclic test, the axial ratcheting strain ɛ x did not accumulate obviously in initial stage, but gradually increased up to 1% with increasing stress amplitude σ xa . For multiaxial ratcheting tests, the zirconium alloy tube was highly sensitive to both the axial stress amplitude σ xa and the internal pressure p i . The hoop ratcheting strain ɛ θ increased continuously with the increase of axial stress amplitude, whereas the evolution of axial ratcheting strain ɛ x was related to the axial stress amplitude. The internal pressure restricted the ratcheting accumulation in the axial direction, but promoted the hoop ratcheting strain on the contrary. The prior loading history greatly restrained the ratcheting behavior of subsequent cycling with a small internal pressure. - Highlights: •Uniaxial and multiaxial ratcheting behavior of the zirconium alloy tubes are investigated at room temperature. •The ratcheting depends greatly on the stress amplitude or internal pressure. •The interaction between the axial and hoop ratcheting mechanisms is greatly dependent on the internal pressure level. •The ratcheting is influenced significantly by the loading history of internal pressure.

  10. First industrial strength multi-axial Robotic testing campaign for composite material characterization

    Science.gov (United States)

    John G. Michopoulos; John C. Hermanson; Athanasios Iliopoulos

    2012-01-01

    In this paper we are reporting on the first successful campaign of systematic, automated and massive multiaxial tests for composite material constitutive characterization. The 6 degrees of freedom system developed at the Naval Research Laboratory (NRL) called NRL66.3, was used for this task. This was the inaugural run that served as the validation of the...

  11. Phenomenological model for coupled multi-axial piezoelectricity

    Science.gov (United States)

    Wei, Yuchen; Pellegrino, Sergio

    2018-03-01

    A quantitative calibration of an existing phenomenological model for polycrystalline ferroelectric ceramics is presented. The model relies on remnant strain and polarization as independent variables. Innovative experimental and numerical model identification procedures are developed for the characterization of the coupled electro-mechanical, multi-axial nonlinear constitutive law. Experiments were conducted on thin PZT-5A4E plates subjected to cross-thickness electric field. Unimorph structures with different thickness ratios between PZT-5A4E plate and substrate were tested, to subject the piezo plates to coupled electro-mechanical fields. Material state histories in electric field-strain-polarization space and stress-strain-polarization space were recorded. An optimization procedure is employed for the determination of the model parameters, and the calibrated constitutive law predicts both the uncoupled and coupled experimental observations accurately.

  12. Evaluation of new multiaxial damage parameters on low carbon steel

    Directory of Open Access Journals (Sweden)

    A. S. Cruces

    2017-07-01

    Full Text Available Most mechanical components are subjected to the complex fatigue loading conditions, where both amplitude and direction of loading cycles change over the time. The estimation of damage caused by these complex loading scenarios are often done by simplified uniaxial fatigue theories, which ultimately leads to higher factor of safety during the final design considerations. Critical plane-based fatigue theories have been considered more accurate for computing the fatigue damage for multiaxial loading conditions in comparison to energy-based and equivalent stress-based theories. Two recently developed fatigue theories have been evaluated in this work for the available test data. Test data includes significant amount of biaxial load paths.

  13. Multiaxial Polarity Determines Individual Cellular and Nuclear Chirality.

    Science.gov (United States)

    Raymond, Michael J; Ray, Poulomi; Kaur, Gurleen; Fredericks, Michael; Singh, Ajay V; Wan, Leo Q

    2017-02-01

    Intrinsic cell chirality has been implicated in the left-right (LR) asymmetry of embryonic development. Impaired cell chirality could lead to severe birth defects in laterality. Previously, we detected cell chirality with an in vitro micropatterning system. Here, we demonstrate for the first time that chirality can be quantified as the coordination of multiaxial polarization of individual cells and nuclei. Using an object labeling, connected component based method, we characterized cell chirality based on cell and nuclear shape polarization and nuclear positioning of each cell in multicellular patterns of epithelial cells. We found that the cells adopted a LR bias the boundaries by positioning the sharp end towards the leading edge and leaving the nucleus at the rear. This behavior is consistent with the directional migration observed previously on the boundary of micropatterns. Although the nucleus is chirally aligned, it is not strongly biased towards or away from the boundary. As the result of the rear positioning of nuclei, the nuclear positioning has an opposite chirality to that of cell alignment. Overall, our results have revealed deep insights of chiral morphogenesis as the coordination of multiaxial polarization at the cellular and subcellular levels.

  14. Fatigue Behavior of 2A12 Aluminum Alloy Under Multiaxial Loading

    Directory of Open Access Journals (Sweden)

    CHEN Ya-jun

    2017-08-01

    Full Text Available The multiaxial fatigue behavior of 2A12 aluminum alloy was studied with SDN100/1000 electro-hydraulic servo tension-torsion fatigue tester under multiple variables, and the failure mechanism was investigated by scanning electron microscopy (SEM. The results show that under the loading condition of equivalent stress, the fatigue life decreases with the increase of phase angle. For the phase angle 0°, some special features can be observed in the crack initial zone, such as the tire pattern,fishbone pattern and stalactite pattern. There are secondary cracks and vague fatigue striations in the crack propagation zone; the multiaxial fatigue life decreases with the change of mean stress for tension or torsion. Some white flocculent oxides can be found in the crack initiation zone, and secondary crack as well as shear-type elongated dimples in the instantaneous fracture zone; facing different loading waveforms, the multiaxial life of sine wave is the longest, triangle wave in the second place, and the square wave is the shortest, under the loading condition of equivalent stress, square wave leads to the maximum structural energy dissipation. Under the low and high two step loading, 2A12 shows training effect.

  15. Experimental study on the Kaiser effect of AE under multiaxial loading in granite

    International Nuclear Information System (INIS)

    Watanabe, Hidehiko; Hiroi, Takehiro

    2012-01-01

    Knowledge of the in-situ stresses is essential for underground excavation design, particularly in evaluating stability of excavation. Acoustic Emission method, which utilizes the Kaiser effect, is one of the simple methods for measuring in-situ stresses. Experiments on the Kaiser effect has been carried out under uniaxial compression and triaxial compression (σ 1 > σ 2 = σ 3 ), but has not been carried out under the three different principal stresses (σ 1 > σ 2 > σ 3 ). In this study, we performed two experiments on the Kaiser effect under multiaxial loading, using a hollow cylindrical granite specimen. The rapidly increasing point of cumulative AE event count was determined as the peak point of AE event count rate increment (AERI). The main results are summarized as follows. (1) In the case of the cyclic incremental σ 1 loading under σ 2 ≠σ 3 , the large peak point of AERI appeared just before the pre-stress level. And as more stresses prior to just before the peak point were estimated, the estimated error showed a tendency to increase. (2) In the case of re-loading under the lower σ 2 and σ 3 more than pre-loading, the estimated stresses using the three peak points of AERI corresponded to the pre-differential stresses (σ 1 -σ 2 ), (σ 1 -σ 3 ) and pre-axial stress σ 1 . The magnitudes of the three principal stresses were estimated under multiaxial loading from the Kaiser effect, using only one specimen. (author)

  16. Spring back evaluation by bending under tension tests in conditions of multiaxial stresses corresponding to deep drawing processes. Application to AISI 304 DDQ stainless steel sheet; Evaluacion del springback mediante ensayos de doblado bajo tension en condiciones de multiaxialidad tipicas de los procesos de embuticion profunda. Aplicacion a chapa de acero inoxidable AISI 304 DDQ

    Energy Technology Data Exchange (ETDEWEB)

    Miguel, V.; Coello, J.; Martinez, A.; Calatayud, A.

    2013-09-01

    In this paper, a methodology has been developed for evaluating the spring back of AISI 304 DDQ stainless steel sheet based on a bending under tension test. The main difference of the methodology herein carried out is that tests are made under the multiaxial stresses state that take place in deep drawing processes. This affects to the level of stress value in the test and to the hardening state of the sheet. Springback evaluation has been done in two different areas. Bending area has been evaluated from elastic recovery ratio defined as the ratio between the bending radius after and before bending. Bending and unbending extreme has been studied from the measured curvature radius in this area and taking into account the geometric equivalence of the test with the drawing cups process. Results found allow to state that drawing ratio or deformation ratio have a negligible influence on the springback into the range of values experimented here. Bending radius has hardly influence as well while bending angle is the most significant variable. The results obtained are compared to those measured in deep-drawn cups, finding a great agreement. (Author)

  17. Metallographic examinations of Type 304 stainless steel (heat 9T2796) tested in high-temperature uniaxial and multiaxial experiments

    Energy Technology Data Exchange (ETDEWEB)

    Swindeman, R.W.; Houck, C.W.

    1984-03-01

    The results obtained from a number of metallographic examinations of Type 304 stainless steel specimens were compiled. Samples were obtained from uniaxial and multiaxial tests covering a very broad span of temperatures and times. Special emphasis was on the identification of failure modes, cracking patterns, grain distortion, and grain-boundary microstructures. Uniaxial specimens exhibited the following sequence of failure modes with increasing temperature and time: ductile plastic tearing, ductile plastic shear, wedge cracking, and microvoid cracking. Over most of the temperature range examined (482 to 871/sup 0/C), M/sub 23/C/sub 6/ precipitated on grain boundaries at long times. Sigma phase and possibly ferrite were often present in the stressed areas at temperatures as low as 482/sup 0/C (900/sup 0/F). These metallurgical features promoted a severe loss in creep ductility at long times and low temperatures. Most multiaxial tests were performed under conditions that promoted wedge cracking. Stress gradients also favored surface crack initiation rather than bulk damage. Testing times for multiaxial tests were less than 10,000 h; hence, there was insufficient time for the development of embrittling features such as microvoids, sigma, and ferrite. Long-time multiaxial tests to failure are recommended.

  18. Unit-Sphere Multiaxial Stochastic-Strength Model Applied to Anisotropic and Composite Materials

    Science.gov (United States)

    Nemeth, Noel, N.

    2013-01-01

    Models that predict the failure probability of brittle materials under multiaxial loading have been developed by authors such as Batdorf, Evans, and Matsuo. These "unit-sphere" models assume that the strength-controlling flaws are randomly oriented, noninteracting planar microcracks of specified geometry but of variable size. This methodology has been extended to predict the multiaxial strength response of transversely isotropic brittle materials, including polymer matrix composites (PMCs), by considering (1) flaw-orientation anisotropy, whereby a preexisting microcrack has a higher likelihood of being oriented in one direction over another direction, and (2) critical strength, or K (sub Ic) orientation anisotropy, whereby the level of critical strength or fracture toughness for mode I crack propagation, K (sub Ic), changes with regard to the orientation of the microstructure. In this report, results from finite element analysis of a fiber-reinforced-matrix unit cell were used with the unit-sphere model to predict the biaxial strength response of a unidirectional PMC previously reported from the World-Wide Failure Exercise. Results for nuclear-grade graphite materials under biaxial loading are also shown for comparison. This effort was successful in predicting the multiaxial strength response for the chosen problems. Findings regarding stress-state interactions and failure modes also are provided.

  19. Optimization of inverse model identification for multi-axial test rig control

    Directory of Open Access Journals (Sweden)

    Müller Tino

    2016-01-01

    Full Text Available Laboratory testing of multi-axial fatigue situations improves repeatability and allows a time condensing of tests which can be carried out until component failure, compared to field testing. To achieve realistic and convincing durability results, precise load data reconstruction is necessary. Cross-talk and a high number of degrees of freedom negatively affect the control accuracy. Therefore a multiple input/multiple output (MIMO model of the system, capturing all inherent cross-couplings is identified. In a first step the model order is estimated based on the physical fundamentals of a one channel hydraulic-servo system. Subsequently, the structure of the MIMO model is optimized using correlation of the outputs, to increase control stability and reduce complexity of the parameter optimization. The identification process is successfully applied to the iterative control of a multi-axial suspension rig. The results show accurate control, with increased stability compared to control without structure optimization.

  20. Dynamic Multiaxial Response of a Hot-Pressed Aluminum Nitride

    Science.gov (United States)

    2012-01-05

    Hutchinson, Adv. Appl . Mech. 29 (1992). [34] H. Ming-Yuan, J.W. Hutchinson, Int. J. Solids Struct. 25 (1989) 1053. [35] J. Salem , L. Ghosn, Int. J...Dynamic Multiaxial Response of a Hot- Pressed Aluminum Nitride by Guangli Hu, C. Q. Chen, K. T. Ramesh, and J. W. McCauley ARL-RP-0487...Laboratory Aberdeen Proving Ground, MD 21005-5066 ARL-RP-0487 June 2014 Dynamic Multiaxial Response of a Hot- Pressed Aluminum Nitride

  1. Dual Numbers Approach in Multiaxis Machines Error Modeling

    Directory of Open Access Journals (Sweden)

    Jaroslav Hrdina

    2014-01-01

    Full Text Available Multiaxis machines error modeling is set in the context of modern differential geometry and linear algebra. We apply special classes of matrices over dual numbers and propose a generalization of such concept by means of general Weil algebras. We show that the classification of the geometric errors follows directly from the algebraic properties of the matrices over dual numbers and thus the calculus over the dual numbers is the proper tool for the methodology of multiaxis machines error modeling.

  2. Multiaxial pedicle screw designs: static and dynamic mechanical testing.

    Science.gov (United States)

    Stanford, Ralph Edward; Loefler, Andreas Herman; Stanford, Philip Mark; Walsh, William R

    2004-02-15

    Randomized investigation of multiaxial pedicle screw mechanical properties. Measure static yield and ultimate strengths, yield stiffness, and fatigue resistance according to an established model. Compare these measured properties with expected loads in vivo. Multiaxial pedicle screws provide surgical versatility, but the complexity of their design may reduce their strength and fatigue resistance. There is no published data on the mechanical properties of such screws. Screws were assembled according to a vertebrectomy model for destructive mechanical testing. Groups of five assemblies were tested in static tension and compression and subject to three cyclical loads. Modes of failure, yield, and ultimate strength, yield stiffness, and cycles to failure were determined for six designs of screw. Static compression yield loads ranged from 217.1 to 388.0 N and yield stiffness from 23.7 to 38.0 N/mm. Cycles to failure ranged from 42 x 10(3) to 4,719 x 10(3) at 75% of static ultimate load. There were significant differences between designs in all modes of testing. Failure occurred at the multiaxial link in static and cyclical compression. Bending yield strengths just exceeded loads expected in vivo. Multiaxial designs had lower static bending yield strength than fixed screw designs. Five out of six multiaxial screw designs achieved one million cycles at 200 N in compression bending. "Ball-in-cup" multiaxial locking mechanisms were vulnerable to fatigue failure. Smooth surfaces and thicker material appeared to be protective against fatigue failure.

  3. A New Energy-Critical Plane Damage Parameter for Multiaxial Fatigue Life Prediction of Turbine Blades

    Directory of Open Access Journals (Sweden)

    Zheng-Yong Yu

    2017-05-01

    Full Text Available As one of fracture critical components of an aircraft engine, accurate life prediction of a turbine blade to disk attachment is significant for ensuring the engine structural integrity and reliability. Fatigue failure of a turbine blade is often caused under multiaxial cyclic loadings at high temperatures. In this paper, considering different failure types, a new energy-critical plane damage parameter is proposed for multiaxial fatigue life prediction, and no extra fitted material constants will be needed for practical applications. Moreover, three multiaxial models with maximum damage parameters on the critical plane are evaluated under tension-compression and tension-torsion loadings. Experimental data of GH4169 under proportional and non-proportional fatigue loadings and a case study of a turbine disk-blade contact system are introduced for model validation. Results show that model predictions by Wang-Brown (WB and Fatemi-Socie (FS models with maximum damage parameters are conservative and acceptable. For the turbine disk-blade contact system, both of the proposed damage parameters and Smith-Watson-Topper (SWT model show reasonably acceptable correlations with its field number of flight cycles. However, life estimations of the turbine blade reveal that the definition of the maximum damage parameter is not reasonable for the WB model but effective for both the FS and SWT models.

  4. Efficient lifetime estimation techniques for general multiaxial loading

    Science.gov (United States)

    Papuga, Jan; Halama, Radim; Fusek, Martin; Rojíček, Jaroslav; Fojtík, František; Horák, David; Pecha, Marek; Tomčala, Jiří; Čermák, Martin; Hapla, Václav; Sojka, Radim; Kružík, Jakub

    2017-07-01

    In this paper, we discuss and present our progress toward a project, which is focused on fatigue life prediction under multiaxial loading in the domain of low-cycle fatigue, i.e. cases, where the plasticity cannot be neglected. First, the elastic-plastic solution in the finite element analysis is enhanced and verified on own experiments. Second, the method by Jiang describing the instantaneous damage increase by analyses of load time by time, is in implementation phase. In addition, simplified routines for conversion of elastic stresses-strains to elastic-plastic ones as proposed by Firat and Ye et.al. are evaluated on the basis of data gathered from external sources. In order to produce high quality complex analyses, which could be feasible in an acceptable time, and allow the period for next analyses of results to be expanded; the core of PragTic fatigue solver used for all fatigue computations are being re-implemented to get the fully parallelized scalable solution.

  5. Preliminary study on flexible core design of super FBR with multi-axial fuel shuffling

    International Nuclear Information System (INIS)

    Sukarman; Yamaji, Akifumi; Someya, Takayuki; Noda, Shogo

    2017-01-01

    Preliminary study has been conducted on developing a new flexible core design concept for the Supercritical water-cooled Fast Breeder Reactor (Super FBR) with multi-axial fuel shuffling. The proposed new concept focuses on the characteristic large axial coolant density change in supercritical water cooled reactors (SCWRs) when the coolant inlet temperature is below the pseudocritical point and large coolant enthalpy rise is taken in the core for achieving high thermal efficiency. The aim of the concept is to attain both the high breeding performance and good thermal-hydraulic performance at the same time. That is, short Compound System Doubling Time (CSDT) for high breeding, large coolant enthalpy rise for high thermal efficiency, and large core power. The proposed core concept consists of horizontal layers of mixed oxide (MOX) fuels and depleted uranium (DU) blanket layers at different elevation levels. Furthermore, the upper core and the lower core are separated and independent fuel shuffling schemes in these two core regions are considered. The number of fuel batches and fuel shuffling scheme of the upper core were changed to investigate influence of multi-axial fuel shuffling on the core characteristics. The core characteristics are evaluated with-three-dimensional diffusion calculations, which are fully-coupled with thermal-hydraulics calculations based on single channel analysis model. The results indicate that the proposed multi-axial fuel shuffling scheme does have a large influence on CSDT. Further investigations are necessary to develop the core concept. (author)

  6. Multiaxial creep of tubes of Alloy 800 and Alloy 617 at high temperature

    International Nuclear Information System (INIS)

    Penkalla, H.J.; Schubert, F.; Nickel, H.

    1989-01-01

    The deformation behaviour under multiaxial loading at temperature higher than 800 deg. C is strongly controlled by creep. For dimensioning and inelastic analysis the use of v. Mises theory and Norton's creep law for stationary creep are demonstrated for different combination of internal pressure and axial or torsional stress or strains. The experimental results are in satisfactory agreement with the theoretical predicted deformation behaviour if values for the coefficient k and n in Norton's creep law are used, which are close to the real creep resistance in the component. (author). 11 refs, 12 figs, 2 tabs

  7. Fatigue of weld ends under combined in- and out-of-phase multiaxial loading

    Directory of Open Access Journals (Sweden)

    E. Shams

    2016-10-01

    Full Text Available Weld start and end points are fatigue failure sensitive locations. Their fatigue behaviour especially in thin sheet structures under multiaxial load conditions is not sufficiently explored so far. Therefore, a research project was initiated to increase the knowledge concerning this topic, which is of special interest in the automotive industry. In the present study, fatigue tests on welded joints were conducted. In the numerical part of the study, notch stresses were calculated with an idealised weld end model. A numerical method which combines the geometrical and statistical size effect to an integrated approach was used, in order to consider the size effects

  8. Anisotropy of domain switching in prepoled lead titanate zirconate ceramics under multiaxial electrical loading

    Science.gov (United States)

    Liu, Yuan-Ming; Li, Fa-Xin; Fang, Dai-Ning

    2007-01-01

    The authors report an observation of anisotropic domain switching process in prepoled lead titanate zirconate (PZT) ceramics under multiaxial electrical loading. Prepoled PZT blocks were obliquely cut to apply an electric field at discrete angles θ (0°-180°) to the initial poling direction. Both the coercive field and switchable polarization are found to decrease significantly when sinθ increases from zero to unity. The measured strain curves show that most domains that accomplished 180° domain switching actually experienced two successive 90° switching. The oriented domain texture after poling plus the induced nonuniform stress are used to explain the observed domain switching anisotropy.

  9. Multiaxial probabilistic elastic-plastic constitutive simulations of soils

    Science.gov (United States)

    Sadrinezhad, Arezoo

    Fokker-Planck-Kolmogorov (FPK) equation approach has recently been developed to simulate elastic-plastic constitutive behaviors of materials with uncertain material properties. The FPK equation approach transforms the stochastic constitutive rate equation, which is a stochastic, nonlinear, ordinary differential equation (ODE) in the stress-pseudo time space into a second-order accurate, deterministic, linear FPK partial differential equation (PDE) in the probability density of stress-pseudo time space. This approach does not suffer from the drawbacks of the traditional approaches such as the Monte Carlo approach and the perturbation approach for solving nonlinear ODEs with random coefficients. In this study, the existing one dimensional FPK framework for probabilistic constitutive modeling of soils is extended to multi--dimension. However, the multivariate FPK PDEs cannot be solved using the traditional mathematical techniques such as finite difference techniques due to their high computational cost. Therefore, computationally efficient algorithms based on the Fourier spectral approach are developed for solving a class of FPK PDEs that arises in probabilistic elasto-plasticity. This class includes linear FPK PDEs in (stress) space and (pseudo) time - having space-independent but time-dependent, and both space- and time-dependent coefficients - with impulse initial conditions and reflecting boundary conditions. The solution algorithms, rely on first mapping the stress space of the governing PDE between 0 and 2pi using the change of coordinates rule, followed by approximating the solution of the PDE in the 2pi-periodic domain by a finite Fourier series in the stress space and unknown time-dependent solution coefficients. Finally, the time-dependent solution coefficients are obtained from the initial condition. The accuracy and efficiency of the developed algorithms are tested. The developed algorithms are used to simulate uniaxial and multiaxial, monotonic and cyclic

  10. Demountable low stress high field toroidal field magnet system for tokamak fusion reactors

    International Nuclear Information System (INIS)

    Powell, J.; Hsieh, D.; Lehner, J.; Suenaga, M.

    1978-01-01

    A new type of superconducting magnet system for large fusion reactors is described. Instead of winding large planar or multi-axis coils, as has been proposed in previous fusion reactor designs, the superconducting coils are made by joining together several prefabricated conductor sections. The joints can be unmade and sections removed if they fail. Conductor sections can be made at a factory and shipped to the reactor site for assembly. The conductor stress level in the assembled coil can be kept small by external support of the coil at a number of points along its perimeter, so that the magnetic forces are transmitted to an external warm reinforcement structure. This warm reinforcement structure can also be the primary containment for the fusion reactor, constructed similar to a PCRV (Prestressed Concrete Reactor Vessel) used in fission reactors. Low thermal conductivity, high strength supports are used to transfer the magnetic forces to the external reinforcement through a hydraulic system. The hydraulic supports are movable and can be programmed to accommodate thermal contraction and to minimize stress in the superconducting coil. (author)

  11. Demountable low stress high field toroidal field magnet system for tokamak fusion reactors

    International Nuclear Information System (INIS)

    Powell, J.; Hsieh, D.; Lehner, J.; Suenaga, M.

    1977-01-01

    A new type of superconducting magnet system for large fusion reactors is described in this report. Instead of winding large planar or multi-axis coils, as has been proposed in previous fusion reactor designs, the superconducting coils are made by joining together several prefabricated conductor sections. The joints can be unmade and sections removed if they fail. Conductor sections can be made at a factory and shipped to the reactor site for assembly. The conductor stress level in the assembled coil can be kept small by external support of the coil at a number of points along its perimeter, so that the magnetic forces are transmitted to an external warm reinforcement structure. This warm reinforcement structure can also be the primary containment for the fusion reactor, constructed similar to a PCRV (Prestressed Concrete Reactor Vessel) used in fission reactors. Low thermal conductivity, high strength supports are used to transfer the magnetic forces to the external reinforcement through a hydraulic system. The hydraulic supports are movable and can be programmed to accommodate thermal contraction and to minimize stress in the superconducting coil

  12. A Critical Plane-energy Model for Multiaxial Fatigue Life Prediction of Homogeneous and Heterogeneous Materials

    Science.gov (United States)

    Wei, Haoyang

    A new critical plane-energy model is proposed in this thesis for multiaxial fatigue life prediction of homogeneous and heterogeneous materials. Brief review of existing methods, especially on the critical plane-based and energy-based methods, are given first. Special focus is on one critical plane approach which has been shown to work for both brittle and ductile metals. The key idea is to automatically change the critical plane orientation with respect to different materials and stress states. One potential drawback of the developed model is that it needs an empirical calibration parameter for non-proportional multiaxial loadings since only the strain terms are used and the out-of-phase hardening cannot be considered. The energy-based model using the critical plane concept is proposed with help of the Mroz-Garud hardening rule to explicitly include the effect of non-proportional hardening under fatigue cyclic loadings. Thus, the empirical calibration for non-proportional loading is not needed since the out-of-phase hardening is naturally included in the stress calculation. The model predictions are compared with experimental data from open literature and it is shown the proposed model can work for both proportional and non-proportional loadings without the empirical calibration. Next, the model is extended for the fatigue analysis of heterogeneous materials integrating with finite element method. Fatigue crack initiation of representative volume of heterogeneous materials is analyzed using the developed critical plane-energy model and special focus is on the microstructure effect on the multiaxial fatigue life predictions. Several conclusions and future work is drawn based on the proposed study.

  13. Characterization of a multi-axis ion chamber array.

    Science.gov (United States)

    Simon, Thomas A; Kozelka, Jakub; Simon, William E; Kahler, Darren; Li, Jonathan; Liu, Chihray

    2010-11-01

    The aim of this work was to characterize a multi-axis ion chamber array (IC PROFILER; Sun Nuclear Corporation, Melbourne, FL, USA) that has the potential to simplify the acquisition of LINAC beam data. The IC PROFILER (or panel) measurement response was characterized with respect to radiation beam properties, including dose, dose per pulse, pulse rate frequency (PRF), and energy. Panel properties were also studied, including detector-calibration stability, power-on time, backscatter dependence, and the panel's agreement with water tank measurements [profiles, fractional depth dose (FDD), and output factors]. The panel's relative deviation was typically within (+/-) 1% of an independent (or nominal) response for all properties that were tested. Notable results were (a) a detectable relative field shape change of approximately 1% with linear accelerator PRF changes; (b) a large range in backscatter thickness had a minimal effect on the measured dose distribution (typically less than 1%); (c) the error spread in profile comparison between the panel and scanning water tank (Blue Phantom, CC13; IBA Schwarzenbruck, DE) was approximately (+/-) 0.75%. The ability of the panel to accurately reproduce water tank profiles, FDDs, and output factors is an indication of its abilities as a dosimetry system. The benefits of using the panel versus a scanning water tank are less setup time and less error susceptibility. The same measurements (including device setup and breakdown) for both systems took 180 min with the water tank versus 30 min with the panel. The time-savings increase as the measurement load is increased.

  14. Fatigue Equivalent Stress State Approach Validation in Non-conservative Criteria: a Comparative Study

    Directory of Open Access Journals (Sweden)

    Kévin Martial Tsapi Tchoupou

    Full Text Available Abstract This paper is concerned with the fatigue prediction models for estimating the multiaxial fatigue limit. An equivalent loading approach with zero out-of-phase angles intended for fatigue limit evaluation under multiaxial loading is used. Based on experimental data found in literatures, the equivalent stress is validated in Crossland and Sines criteria and predictions compared to the predictions of existing multiaxial fatigue; results over 87 experimental items show that the equivalent stress approach is very efficient.

  15. Joined application of a multiaxial critical plane criterion and a strain energy density criterion in low-cycle fatigue

    Directory of Open Access Journals (Sweden)

    Andrea Carpinteri

    2017-07-01

    Full Text Available In the present paper, the multiaxial fatigue life assessment of notched structural components is performed by employing a strain-based multiaxial fatigue criterion. Such a criterion, depending on the critical plane concept, is extended by implementing the control volume concept reated to the Strain Energy Density (SED approach: a material point located at a certain distance from the notch tip is assumed to be the verification point where to perform the above assessment. Such a distance, measured along the notch bisector, is a function of both the biaxiality ratio (defined as the ratio between the applied shear stress amplitude and the normal stress amplitude and the control volume radii under Mode I and Mode III. Once the position of the verification point is determined, the fatigue lifetime is assessed through an equivalent strain amplitude, acting on the critical plane, together with a unique material reference curve (i.e. the Manson-Coffin curve. Some uniaxial and multiaxial fatigue data related to V-notched round bars made of titanium grade 5 alloy (Ti-6Al-4V are examined to validate the present criterion.

  16. Multiaxial creep-fatigue life analysis using strainrange partitioning

    International Nuclear Information System (INIS)

    Manson, S.S.; Halford, G.R.

    1976-01-01

    Strain-Range Partitioning is a recently developed method for treating creep-fatigue interaction at elevated temperature. Most of the work to date has been on uniaxially loaded specimens, whereas practical applications often involve load multiaxiality. This paper shows how the method can be extended to treat multiaxiality through a set of rules for combining the strain components in the three principal directions. Closed hysteresis loops, as well as plastic and creep strain ratcheting, are included. An application to hold-time tests in torsion is used to illustrate the approach

  17. Development of a method of lifetime assessment of power plant components under complex multi-axial vibration loads

    International Nuclear Information System (INIS)

    Fesich, Thomas M.

    2012-01-01

    In general, technical components are loaded and stressed by forces and moments both constant and variable over time. Multi-axial stress conditions can arise as a function of the load on, and/or the geometry of, a component. Assessing the impact on stability of multi-axial stress conditions is a problem for which no generally valid solution has as yet been found, especially when loads and stresses vary over time. This is also due to the fact that the development over time of stresses can give rise to very complex stress conditions. Assessing the lifetime of power plant components subjected to complex vibration loads and stresses often is not reliable if performed by means of conventional codes and approaches, or is associated with high degrees of conservatism. The MPA AIM-Life concept developed at the Stuttgart MPA/IMWF, which is an advanced and verified strength hypothesis based on energy considerations, allows such assessments to be made more reliably, numerically efficient, and avoiding excessive conservatism. (orig.)

  18. Stress Effects on Multiple Memory System Interactions

    Science.gov (United States)

    Ness, Deborah; Calabrese, Pasquale

    2016-01-01

    Extensive behavioural, pharmacological, and neurological research reports stress effects on mammalian memory processes. While stress effects on memory quantity have been known for decades, the influence of stress on multiple memory systems and their distinct contributions to the learning process have only recently been described. In this paper, after summarizing the fundamental biological aspects of stress/emotional arousal and recapitulating functionally and anatomically distinct memory systems, we review recent animal and human studies exploring the effects of stress on multiple memory systems. Apart from discussing the interaction between distinct memory systems in stressful situations, we will also outline the fundamental role of the amygdala in mediating such stress effects. Additionally, based on the methods applied in the herein discussed studies, we will discuss how memory translates into behaviour. PMID:27034845

  19. Stress Effects on Multiple Memory System Interactions

    Directory of Open Access Journals (Sweden)

    Deborah Ness

    2016-01-01

    Full Text Available Extensive behavioural, pharmacological, and neurological research reports stress effects on mammalian memory processes. While stress effects on memory quantity have been known for decades, the influence of stress on multiple memory systems and their distinct contributions to the learning process have only recently been described. In this paper, after summarizing the fundamental biological aspects of stress/emotional arousal and recapitulating functionally and anatomically distinct memory systems, we review recent animal and human studies exploring the effects of stress on multiple memory systems. Apart from discussing the interaction between distinct memory systems in stressful situations, we will also outline the fundamental role of the amygdala in mediating such stress effects. Additionally, based on the methods applied in the herein discussed studies, we will discuss how memory translates into behaviour.

  20. Stress Effects on Multiple Memory System Interactions.

    Science.gov (United States)

    Ness, Deborah; Calabrese, Pasquale

    2016-01-01

    Extensive behavioural, pharmacological, and neurological research reports stress effects on mammalian memory processes. While stress effects on memory quantity have been known for decades, the influence of stress on multiple memory systems and their distinct contributions to the learning process have only recently been described. In this paper, after summarizing the fundamental biological aspects of stress/emotional arousal and recapitulating functionally and anatomically distinct memory systems, we review recent animal and human studies exploring the effects of stress on multiple memory systems. Apart from discussing the interaction between distinct memory systems in stressful situations, we will also outline the fundamental role of the amygdala in mediating such stress effects. Additionally, based on the methods applied in the herein discussed studies, we will discuss how memory translates into behaviour.

  1. Supervising System Stress in Multiple Markets

    Directory of Open Access Journals (Sweden)

    Mikhail V. Oet

    2015-09-01

    Full Text Available This paper develops an extended financial stress measure that considers the supervisory objective of identifying risks to the stability of the financial system. The measure provides a continuous and bounded signal of financial stress using daily public market data. Broad coverage of material financial system markets over time is achieved by leveraging dynamic credit weights. We consider how this measure can be used to monitor, analyze, and alert financial system stress.

  2. Evaluation of electromagnetic shielding effectiveness of multi-axial ...

    Indian Academy of Sciences (India)

    2016-08-26

    Aug 26, 2016 ... ... Lecture Workshops · Refresher Courses · Symposia. Home; Journals; Bulletin of Materials Science; Volume 39; Issue 4. Evaluation of electromagnetic shielding effectiveness of multi-axial fabrics and their reinforced PES composites. RAMAZAN ERDEM. Volume 39 Issue 4 August 2016 pp 963-970 ...

  3. Evaluation of electromagnetic shielding effectiveness of multi-axial ...

    Indian Academy of Sciences (India)

    The usage of electrical and electronic equipments has been increasing in daily life, which has a potential hazardous impact on humans and other living organisms. In this paper, multi-axial fabrics containing steel yarns and carbon filaments, and their polyester (PES) resin-reinforced composites have been prepared for ...

  4. Concurrent Validity of the Millon Clinical Multiaxial Inventory Depression Scales.

    Science.gov (United States)

    Goldberg, Joel O.; And Others

    1987-01-01

    Compared two new measures of depression (Millon Multiaxial Inventory Dysthymia and Major Depression subscales) with two established instruments: Beck Depression Inventory, a self-report measure which emphasizes the cognitive-affective aspects of depression, and Hamilton Rating Scale for Depression, an interview measure that emphasizes somatic…

  5. Multi-axial mechanical stimulation of tissue engineered cartilage: Review

    Directory of Open Access Journals (Sweden)

    S D Waldman

    2007-04-01

    Full Text Available The development of tissue engineered cartilage is a promising new approach for the repair of damaged or diseased tissue. Since it has proven difficult to generate cartilaginous tissue with properties similar to that of native articular cartilage, several studies have used mechanical stimuli as a means to improve the quantity and quality of the developed tissue. In this study, we have investigated the effect of multi-axial loading applied during in vitro tissue formation to better reflect the physiological forces that chondrocytes are subjected to in vivo. Dynamic combined compression-shear stimulation (5% compression and 5% shear strain amplitudes increased both collagen and proteoglycan synthesis (76 ± 8% and 73 ± 5%, respectively over the static (unstimulated controls. When this multi-axial loading condition was applied to the chondrocyte cultures over a four week period, there were significant improvements in both extracellular matrix (ECM accumulation and the mechanical properties of the in vitro-formed tissue (3-fold increase in compressive modulus and 1.75-fold increase in shear modulus. Stimulated tissues were also significantly thinner than the static controls (19% reduction suggesting that there was a degree of ECM consolidation as a result of long-term multi-axial loading. This study demonstrated that stimulation by multi-axial forces can improve the quality of the in vitro-formed tissue, but additional studies are required to further optimize the conditions to favour improved biochemical and mechanical properties of the developed tissue.

  6. Stress Effects on Multiple Memory System Interactions

    OpenAIRE

    Ness, Deborah; Calabrese, Pasquale

    2016-01-01

    Extensive behavioural, pharmacological, and neurological research reports stress effects on mammalian memory processes. While stress effects on memory quantity have been known for decades, the influence of stress on multiple memory systems and their distinct contributions to the learning process have only recently been described. In this paper, after summarizing the fundamental biological aspects of stress/emotional arousal and recapitulating functionally and anatomically distinct memory syst...

  7. Assessment of an improved multiaxial strength theory based on creep-rupture data for Inconel 600

    International Nuclear Information System (INIS)

    Huddleston, R.L.

    1993-01-01

    A new multiaxial strength theory incorporating three independent stress parameters was developed and reported by the author in 1984. It was formally incorporated into ASME Code Case N47-29 in 1990. The new theory provided significantly more accurate stress-rupture life predictions than obtained using the classical theories of von Mises, Tresca, and Rankins (maximum principal stress), for Types 304 and 316 stainless steel tested at 593 and 600 degrees C respectively under different biaxial stress states. Additional results for Inconel 600 specimens tested at 816 degrees C under tension-tension and tension-compression stress states are presented in this paper and show a factor of approximately 2.4 reduction in the scatter of predicted versus observed lives as compared to the classical theories of von Mises and Tresca and a factor of about 5 as compared to the Rankins theory. A key feature of the theory, which incorporates the maximum deviatoric stress, the first invariant of the stress tensor, and the second invariant of the deviatoric stress tensor, is its ability to distinguish between life under tensile versus compressive stress states

  8. Reduced softening of EUROFER 97 under thermo-mechanical and multiaxial fatigue loading and its impact on the design rules

    International Nuclear Information System (INIS)

    Aktaa, J.; Weick, M.; Petersen, C.

    2007-01-01

    Full text of publication follows: Toward test blanket module (TBM) in ITER and DEMO fusion power plants design rules for components built from EUROFER 97 get more and more in the midpoint of interest. One of the specific characteristic of EUROFER 97 as a ferritic-martensitic steel is its cyclic softening yielding to lower stresses under strain controlled fatigue loading and thus longer lifetimes. However our thermo-mechanical and multiaxial fatigue tests showed lifetimes remarkably lower than those expected on the base of isothermal uniaxial fatigue tests. Reduced cyclic softening observed in these experiments is believed as one of the reasons of the shorter fatigue lifetimes. When applying the design rules, derived for EUROFER 97 on the base of isothermal uniaxial data considering the recommendations in the ASME and RCC-MR code, to our thermo-mechanical and multiaxial fatigue tests for verification strong loss in their conservatism has been found. The lifetimes observed in a part of the multiaxial experiments are even lower than the design lifetimes supposed to be sufficiently conservative. To overcome this problem new design rules are proposed among others on the base of damage and lifetime prediction model developed lately for EUROFER 97. In this paper the experimental findings as well as the new design approaches will be presented and discussed. (authors)

  9. Role of Inelastic Transverse Compressive Behavior and Multiaxial Loading on the Transverse Impact of Kevlar KM2 Single Fiber

    Directory of Open Access Journals (Sweden)

    Subramani Sockalingam

    2017-02-01

    Full Text Available High-velocity transverse impact of ballistic fabrics and yarns by projectiles subject individual fibers to multi-axial dynamic loading. Single-fiber transverse impact experiments with the current state-of-the-art experimental capabilities are challenging due to the associated micron length-scale. Kevlar® KM2 fibers exhibit a nonlinear inelastic behavior in transverse compression with an elastic limit less than 1.5% strain. The effect of this transverse behavior on a single KM2 fiber subjected to a cylindrical and a fragment-simulating projectile (FSP transverse impact is studied with a 3D finite element model. The inelastic behavior results in a significant reduction of fiber bounce velocity and projectile-fiber contact forces up to 38% compared to an elastic impact response. The multiaxial stress states during impact including transverse compression, axial tension, axial compression and interlaminar shear are presented at the location of failure. In addition, the models show a strain concentration over a small length in the fiber under the projectile-fiber contact. A failure criterion, based on maximum axial tensile strain accounting for the gage length, strain rate and multiaxial loading degradation effects are applied to predict the single-fiber breaking speed. Results are compared to the elastic response to assess the importance of inelastic material behavior on failure during a transverse impact.

  10. Stress, catecholaminergic system and cancer.

    Science.gov (United States)

    Krizanova, O; Babula, P; Pacak, K

    2016-07-01

    Stress as a modern civilization factor significantly affects our lives. While acute stress might have a positive effect on the organism, chronic stress is usually detrimental and might lead to serious health complications. It is known that stress induced by the physical environment (temperature-induced cold stress) can significantly impair the efficacy of cytotoxic chemotherapies and the anti-tumor immune response. On the other hand, epidemiological evidence has shown that patients taking drugs known as β-adrenergic antagonists ("β-blockers"), which are commonly prescribed to treat arrhythmia, hypertension, and anxiety, have significantly lower rates of several cancers. In this review, we summarize the current knowledge about catecholamines as important stress hormones in tumorigenesis and discuss the use of β-blockers as the potential therapeutic agents.

  11. Measurement of multiaxial ply strength by an off-axis flexure test

    Science.gov (United States)

    Crews, John H., Jr.; Naik, Rajiv A.

    1992-01-01

    An off-axis flexure (OAF) test was performed to measure ply strength under multiaxial stress states. This test involves unidirectional off-axis specimens loaded in bending, using an apparatus that allows these anisotropic specimens to twist as well as flex without the complications of a resisting torque. A 3D finite element stress analysis verified that simple beam theory could be used to compute the specimen bending stresses at failure. Unidirectional graphite/epoxy specimens with fiber angles ranging from 90 deg to 15 deg have combined normal and shear stresses on their failure planes that are typical of 45 deg plies in structural laminates. Tests for a range of stress states with AS4/3501-6 specimens showed that both normal and shear stresses on the failure plane influenced cracking resistance. This OAF test may prove to be useful for generating data needed to predict ply cracking in composite structures and may also provide an approach for studying fiber-matrix interface failures under stress states typical of structures.

  12. Fatigue damage assessment under multi-axial non-proportional cyclic loading

    International Nuclear Information System (INIS)

    Mohta, Keshav; Gupta, Suneel K.; Jadhav, P.A.; Bhasin, V.; Vijayan, P.K.

    2016-01-01

    Detailed fatigue analysis is carried out for class I Nuclear Power Plant (NPP) components to rule out the fatigue failure during their design lifetime. ASME Boiler and Pressure Vessel code Section III NB, has provided two schemes for fatigue assessment, one for fixed principal directions (proportional) loading and the other for varying principal directions (non-proportional) loading conditions. Recent literature on multi-axial fatigue tests has revealed lower fatigue lives under nonproportional loading conditions. In an attempt to understand the loading parameter lowering the fatigue life, a finite element based study has been carried out. Here, fatigue damage in a tube has been correlated with the applied axial to shear strain ratio and phase difference between them. The FE analysis has used Chaboche nonlinear kinematic hardening rule to model material's realistic cyclic plastic deformation behavior. The ASME alternating stress intensity (based on linear elastic FEA) and the plastic strain energy dissipation (based on elastic-plastic FEA) have been considered to assess the per cycle fatigue damage. The study has revealed that ASME criteria predicts lower alternating stress intensity (fatigue damage parameter S alt ) for some cases of non-proportional loading than that predicted for corresponding proportional loading case. However, the actual fatigue damage is higher in non-proportional loading than that in corresponding proportional loading case. Further the fatigue damage of an NPP component under realistic multi-axial cyclic loading conditions has been assessed using some popular critical plane based models vis-à-vis ASME Sec. III criteria. (author)

  13. Design and analysis of multiaxial creep tests

    International Nuclear Information System (INIS)

    Mallett, R.H.; Dhalla, A.K.; Yocolano, J.T.

    1974-01-01

    A procedure is described for presenting the complete data as obtained from tests of thin-walled tubular creep test specimens. Thereafter, a procedure for processing the data is presented. The processed data is based in part upon results of detailed inelastic finite element analyses performed to determine uniform and constant stress quantities and effective gage lengths. (U.S.)

  14. Oxidative Stress and Antioxidant System in Periodontitis

    Science.gov (United States)

    Wang, Yue; Andrukhov, Oleh; Rausch-Fan, Xiaohui

    2017-01-01

    Periodontitis is a common inflammatory disease, which is initiated by bacterial infection and subsequently progressed by aberrant host response. It can result in the destruction of teeth supporting tissues and have an influence on systemic health. When periodontitis occurs, reactive oxygen species, which are overproduced mostly by hyperactive neutrophils, could not be balanced by antioxidant defense system and cause tissues damage. This is characterized by increased metabolites of lipid peroxidation, DNA damage and protein damage. Local and systemic activities of antioxidants can also be influenced by periodontitis. Total antioxidant capacity, total oxidant status and oxidative stress index have been used to evaluate the oxidative stress associated with periodontitis. Studies have confirmed that inflammatory response in periodontitis is associated with an increased local and systemic oxidative stress and compromised antioxidant capacity. Our review focuses on increased oxidative stress in periodontal disease, specifically, on the relationship between the local and systemic biomarkers of oxidative stress and periodontitis and their association with the pathogenesis of periodontitis. Also, the relationship between periodontitis and systemic inflammation, and the effects of periodontal therapy on oxidative stress parameters will be discussed. PMID:29180965

  15. Microbial stress tolerance for biofuels. Systems biology

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Zonglin Lewis (ed.) [National Center for Agricultural Utilization Research, USDA-ARS, Peoria, IL (United States)

    2012-07-01

    The development of sustainable and renewable biofuels is attracting growing interest. It is vital to develop robust microbial strains for biocatalysts that are able to function under multiple stress conditions. This Microbiology Monograph provides an overview of methods for studying microbial stress tolerance for biofuels applications using a systems biology approach. Topics covered range from mechanisms to methodology for yeast and bacteria, including the genomics of yeast tolerance and detoxification; genetics and regulation of glycogen and trehalose metabolism; programmed cell death; high gravity fermentations; ethanol tolerance; improving biomass sugar utilization by engineered Saccharomyces; the genomics on tolerance of Zymomonas mobilis; microbial solvent tolerance; control of stress tolerance in bacterial host organisms; metabolomics for ethanologenic yeast; automated proteomics work cell systems for strain improvement; and unification of gene expression data for comparable analyses under stress conditions. (orig.)

  16. Multiaxial creep behavior of 304 stainless steel

    International Nuclear Information System (INIS)

    Findley, W.N.; Mark, R.

    1975-07-01

    Tests in combined tension-torsion, pure tension and pure torsion, were conducted at elevated temperature (about 1100 0 F). Most of these tests were repeats of previous experiments where friction in the extensometer caused anomalous creep behavior. The existence of a creep surface at 12.5 ksi effective Mises stress was explored. Work on a compression creep apparatus continued. Creep and recovery data were fitted to the equation epsilon/sub ij/ = epsilon 0 /sub ij/ + e + /sub ij/t/sup n//sub ij/ by means of a least squares method. (5 tables, 10 fig) (auth)

  17. Probabilistic multi-scale models and measurements of self-heating under multiaxial high cycle fatigue

    International Nuclear Information System (INIS)

    Poncelet, M.; Hild, F.; Doudard, C.; Calloch, S.; Weber, B.

    2010-01-01

    Different approaches have been proposed to link high cycle fatigue properties to thermal measurements under cyclic loadings, usually referred to as 'self-heating tests'. This paper focuses on two models whose parameters are tuned by resorting to self-heating tests and then used to predict high cycle fatigue properties. The first model is based upon a yield surface approach to account for stress multi-axiality at a microscopic scale, whereas the second one relies on a probabilistic modelling of micro-plasticity at the scale of slip-planes. Both model identifications are cost effective, relying mainly on quickly obtained temperature data in self-heating tests. They both describe the influence of the stress heterogeneity, the volume effect and the hydrostatic stress on fatigue limits. The thermal effects and mean fatigue limit predictions are in good agreement with experimental results for in and out-of phase tension-torsion loadings. In the case of fatigue under non-proportional loading paths, the mean fatigue limit prediction error of the critical shear stress approach is three times less than with the yield surface approach. (authors)

  18. Probabilistic multi-scale models and measurements of self-heating under multiaxial high cycle fatigue

    Energy Technology Data Exchange (ETDEWEB)

    Poncelet, M.; Hild, F. [Univ Paris 11, PRES, Univ Paris 06, LMT Cachan, ENS Cachan, CNRS, F-94235 Cachan (France); Doudard, C.; Calloch, S. [Univ Brest, ENIB, ENSIETA, LBMS EA 4325, F-29806 Brest, (France); Weber, B. [ArcelorMittal Maizieres Res Voie Romaine, F-57283 Maizieres Les Metz (France)

    2010-07-01

    Different approaches have been proposed to link high cycle fatigue properties to thermal measurements under cyclic loadings, usually referred to as 'self-heating tests'. This paper focuses on two models whose parameters are tuned by resorting to self-heating tests and then used to predict high cycle fatigue properties. The first model is based upon a yield surface approach to account for stress multi-axiality at a microscopic scale, whereas the second one relies on a probabilistic modelling of micro-plasticity at the scale of slip-planes. Both model identifications are cost effective, relying mainly on quickly obtained temperature data in self-heating tests. They both describe the influence of the stress heterogeneity, the volume effect and the hydrostatic stress on fatigue limits. The thermal effects and mean fatigue limit predictions are in good agreement with experimental results for in and out-of phase tension-torsion loadings. In the case of fatigue under non-proportional loading paths, the mean fatigue limit prediction error of the critical shear stress approach is three times less than with the yield surface approach. (authors)

  19. Assessment of laserbeam-welded tubular overlap joints made of magnesium and aluminium under multiaxial loading; Bemessung laserstrahlgeschweisster Ueberlappverbindungen aus Magnesium und Aluminium unter mehrachsiger Beanspruchung

    Energy Technology Data Exchange (ETDEWEB)

    Exel, Nora; Wiebesiek, Jens; Sonsino, Cetin Morris [Fraunhofer-Institut fuer Betriebsfestigkeit und Systemzuverlaessigkeit (LBF), Darmstadt (Germany); Hanselka, Holger [Fraunhofer-Institut fuer Betriebsfestigkeit und Systemzuverlaessigkeit (LBF), Darmstadt (Germany); Technische Univ. Darmstadt (Germany). Fachgebiet ' ' Systemzuverlaessigkeit und Maschinenakustik' '

    2013-07-01

    The present paper compares the wrought light-metal alloys AlMg3.5Mn and MgAl3Zn1 based on the fatigue behaviour of laserbeam-welded overlapped tubular joints. The experiments were carried out under pure axial, pure torsional and combined proportional as well as nonproportional loading. The test results were assessed by applying the notch stress concept with a reference radius of r{sub ref} = 0,05 mm and compared with allowable stresses taken from a standard. Finally, two stress based multiaxial hypothesis are compared to each other based on the test results. (orig.)

  20. Stress, eating and the reward system.

    Science.gov (United States)

    Adam, Tanja C; Epel, Elissa S

    2007-07-24

    An increasing number of people report concerns about the amount of stress in their life. At the same time obesity is an escalating health problem worldwide. Evidence is accumulating rapidly that stress related chronic stimulation of the hypothalamic-pituitary-adrenal (HPA) axis and resulting excess glucocorticoid exposure may play a potential role in the development of visceral obesity. Since adequate regulation of energy and food intake under stress is important for survival, it is not surprising that the HPA axis is not only the 'conductor' of an appropriate stress response, but is also tightly intertwined with the endocrine regulation of appetite. Here we attempt to link animal and human literatures to tease apart how different types of psychological stress affect eating. We propose a theoretical model of Reward Based Stress Eating. This model emphasizes the role of cortisol and reward circuitry on motivating calorically dense food intake, and elucidating potential neuroendocrine mediators in the relationship between stress and eating. The addiction literature suggests that the brain reward circuitry may be a key player in stress-induced food intake. Stress as well as palatable food can stimulate endogenous opioid release. In turn, opioid release appears to be part of an organisms' powerful defense mechanism protecting from the detrimental effects of stress by decreasing activity of the HPA axis and thus attenuating the stress response. Repeated stimulation of the reward pathways through either stress induced HPA stimulation, intake of highly palatable food or both, may lead to neurobiological adaptations that promote the compulsive nature of overeating. Cortisol may influence the reward value of food via neuroendocrine/peptide mediators such as leptin, insulin and neuropeptide Y (NPY). Whereas glucocorticoids are antagonized by insulin and leptin acutely, under chronic stress, that finely balanced system is dysregulated, possibly contributing to increased food

  1. Oxidative stress and the ageing endocrine system.

    Science.gov (United States)

    Vitale, Giovanni; Salvioli, Stefano; Franceschi, Claudio

    2013-04-01

    Ageing is a process characterized by a progressive decline in cellular function, organismal fitness and increased risk of age-related diseases and death. Several hundred theories have attempted to explain this phenomenon. One of the most popular is the 'oxidative stress theory', originally termed the 'free radical theory'. The endocrine system seems to have a role in the modulation of oxidative stress; however, much less is known about the role that oxidative stress might have in the ageing of the endocrine system and the induction of age-related endocrine diseases. This Review outlines the interactions between hormones and oxidative metabolism and the potential effects of oxidative stress on ageing of endocrine organs. Many different mechanisms that link oxidative stress and ageing are discussed, all of which converge on the induction or regulation of inflammation. All these mechanisms, including cell senescence, mitochondrial dysfunction and microRNA dysregulation, as well as inflammation itself, could be targets of future studies aimed at clarifying the effects of oxidative stress on ageing of endocrine glands.

  2. A multi-axis MEMS sensor with integrated carbon nanotube-based piezoresistors for nanonewton level force metrology

    International Nuclear Information System (INIS)

    Cullinan, Michael A; Panas, Robert M; Culpepper, Martin L

    2012-01-01

    This paper presents the design and fabrication of a multi-axis microelectromechanical system (MEMS) force sensor with integrated carbon nanotube (CNT)-based piezoresistive sensors. Through the use of proper CNT selection and sensor fabrication techniques, the performance of the CNT-based MEMS force sensor was increased by approximately two orders of magnitude as compared to current CNT-based sensor systems. The range and resolution of the force sensor were determined as 84 μN and 5.6 nN, respectively. The accuracy of the force sensor was measured to be better than 1% over the device’s full range. (paper)

  3. Multi-Axis Heterodyne Interferometry (MAHI)

    Science.gov (United States)

    Thorpe, James

    . We propose to develop a laboratory prototype of a LISA-like interferometric metrology system capable of simultaneously making picometer-level position and nanoradian-level attitude measurements of a free-flying target. In the LISA application, this prototype would represent the short-arm interferometer, measuring the displacement and relative attitude between the gravitational test mass and the spacecraft. This measurement is used both to drive the drag-free attitude and control system as well as to extract the gravitational wave science signal. In addition to the LISA application, such a system would have broader applications in future geodesy and formation-flying missions. The prototype free-flying metrology system will consist of the following subcomponents: an optical bench providing stable pathlengths, an optical target mounted on a precision actuator, a low-noise quadrant photoreceiver for generating differential wavefront signals, and a phase measurement system to measure the individual heterodyne signals and convert them into quantities such as position and angle. In addition to the moving target, the optical bench will include a pair of fixed targets to be used as references. Comparing the two reference interferometers will provide an estimate of the noise performance of the measurement system, while comparing a reference interferometer with the free-flying target will allow us to demonstrate measurement over a large dynamic range. In addition to making performance measurements, we will use this prototype system to explore a number of system-level issues related to free-flying interferometry including initial acquisition, beam-walk effects, and jitter couplings.

  4. Coordinated control of multi-axis tasks

    International Nuclear Information System (INIS)

    Mc Kinnon, G.M.; King, M.L.; Runnings, D.W.

    1987-01-01

    The use of manipulators and the development of manipulator technology has steadily increased in recent years. Consequently, teleoperation of the remote operation of a machine or piece of equipment has also increased. Typically, teleoperation is employed in situations where the environment is dangerous or too remote for humans to work. In space exploration with the use of dextrous manipulators, teleoperation has become a critical component. This paper describes tests carried out to evaluate three man-machine interfaces with two dextrous manipulators. The three interfaces were a master/slave system with force reflection, a master slave system without force reflection, and two six degree of freedom handcontrollers. Results indicated that task accuracy was superior with the handcontrollers

  5. Multi-axial Creep and the LICON Methodology for Accelerated Creep Testing

    International Nuclear Information System (INIS)

    Bowyer, William H.

    2006-05-01

    The copper-Iron canister for disposal of nuclear waste in the Swedish Programme has a design life exceeding 100,000 years. Whilst the operating temperature (100 deg C max.) and operating stress (50 MPa max.) are modest, the very long design life does require that the likely creep performance of the canister should be investigated. Many studies have been carried out by SKB but these have all involved very short duration tests at relatively high stresses. The process of predicting canister creep life by extrapolation of data from such tests has been challenged for two main reasons. The first is that the deformation and failure mechanisms in the tests employed are different from the mechanism expected under service conditions and the second is that the extrapolation is extreme. It has been recognised that there is usually scope for some increase in test temperatures and stresses which will accelerate the development of creep damage without compromising the use of extrapolation for life prediction. Cane demonstrated that in steels designed for high temperature and pressure applications, conditions of multi-axial stressing could lead to increases or decreases in the rate of damage accumulation without changing the damage mechanism. This provided a third method for accelerating creep testing which has been implemented as the LICON method. This report aims to explain the background to the LICON method and its application to the case of the copper canister. It seems likely that the method could be used to improve our knowledge of the creep resistance of the copper canister. Multiplication factors that may be achieved by the technique could be increased by attention to specimen design but an extensive and targeted programme of data collection on creep of copper would still be needed to implement the method to best advantage

  6. Multi-axial Creep and the LICON Methodology for Accelerated Creep Testing

    Energy Technology Data Exchange (ETDEWEB)

    Bowyer, William H. [Meadow End Farm, Farnham (United Kingdom)

    2006-05-15

    The copper-Iron canister for disposal of nuclear waste in the Swedish Programme has a design life exceeding 100,000 years. Whilst the operating temperature (100 deg C max.) and operating stress (50 MPa max.) are modest, the very long design life does require that the likely creep performance of the canister should be investigated. Many studies have been carried out by SKB but these have all involved very short duration tests at relatively high stresses. The process of predicting canister creep life by extrapolation of data from such tests has been challenged for two main reasons. The first is that the deformation and failure mechanisms in the tests employed are different from the mechanism expected under service conditions and the second is that the extrapolation is extreme. It has been recognised that there is usually scope for some increase in test temperatures and stresses which will accelerate the development of creep damage without compromising the use of extrapolation for life prediction. Cane demonstrated that in steels designed for high temperature and pressure applications, conditions of multi-axial stressing could lead to increases or decreases in the rate of damage accumulation without changing the damage mechanism. This provided a third method for accelerating creep testing which has been implemented as the LICON method. This report aims to explain the background to the LICON method and its application to the case of the copper canister. It seems likely that the method could be used to improve our knowledge of the creep resistance of the copper canister. Multiplication factors that may be achieved by the technique could be increased by attention to specimen design but an extensive and targeted programme of data collection on creep of copper would still be needed to implement the method to best advantage.

  7. Multi-axial load application and DIC measurement of advanced composite beam deformation behavior

    Directory of Open Access Journals (Sweden)

    Berggreen C.

    2010-06-01

    Full Text Available For the validation of a new beam element formulation, a wide set of experimental data consisting of deformation patterns obtained for a number of specially designed composite beam elements, have been obtained. The composite materials applied in the beams consist of glass-fiber reinforced plastic with specially designed layup configurations promoting advanced coupling behavior. Furthermore, the beams are designed with different cross-section shapes. The data obtained from the experiments are also used in order to improve the general understanding related to practical implementation of mechanisms of elastic couplings due to anisotropic properties of composite materials. The knowledge gained from these experiments is therefore essential in order to facilitate an implementation of passive control in future large wind turbine blades. A test setup based on a four-column MTS servo-hydraulic testing machine with a maximum capacity of 100 kN was developed, see Figure 1. The setup allows installing and testing beams of different cross-sections applying load cases such as axial extension, shear force bending, pure bending in two principal directions as well as pure torsion, see Figure 2. In order to apply multi-axial loading, a load application system consisting of three hydraulic actuators were mounted in two planes using multi-axial servo-hydraulic control. The actuator setup consists of the main actuator on the servo-hydraulic test machine working in the vertical axis (depicted on Figure 1 placed at the testing machine crosshead and used for application of vertical forces to the specimens. Two extra actuators are placed in a horizontal plane on the T-slot table of the test machine in different positions in order to apply loading at the tip of the specimen in various configurations. In order to precisely characterize the global as well as surface deformations of the beam specimens tested, a combination of different measurement systems were used during

  8. Fatigue Assessment of Nickel-Titanium Peripheral Stents: Comparison of Multi-Axial Fatigue Models

    Science.gov (United States)

    Allegretti, Dario; Berti, Francesca; Migliavacca, Francesco; Pennati, Giancarlo; Petrini, Lorenza

    2018-02-01

    Peripheral Nickel-Titanium (NiTi) stents exploit super-elasticity to treat femoropopliteal artery atherosclerosis. The stent is subject to cyclic loads, which may lead to fatigue fracture and treatment failure. The complexity of the loading conditions and device geometry, coupled with the nonlinear material behavior, may induce multi-axial and non-proportional deformation. Finite element analysis can assess the fatigue risk, by comparing the device state of stress with the material fatigue limit. The most suitable fatigue model is not fully understood for NiTi devices, due to its complex thermo-mechanical behavior. This paper assesses the fatigue behavior of NiTi stents through computational models and experimental validation. Four different strain-based models are considered: the von Mises criterion and three critical plane models (Fatemi-Socie, Brown-Miller, and Smith-Watson-Topper models). Two stents, made of the same material with different cell geometries are manufactured, and their fatigue behavior is experimentally characterized. The comparison between experimental and numerical results highlights an overestimation of the failure risk by the von Mises criterion. On the contrary, the selected critical plane models, even if based on different damage mechanisms, give a better fatigue life estimation. Further investigations on crack propagation mechanisms of NiTi stents are required to properly select the most reliable fatigue model.

  9. Fatigue Assessment of Nickel-Titanium Peripheral Stents: Comparison of Multi-Axial Fatigue Models

    Science.gov (United States)

    Allegretti, Dario; Berti, Francesca; Migliavacca, Francesco; Pennati, Giancarlo; Petrini, Lorenza

    2018-03-01

    Peripheral Nickel-Titanium (NiTi) stents exploit super-elasticity to treat femoropopliteal artery atherosclerosis. The stent is subject to cyclic loads, which may lead to fatigue fracture and treatment failure. The complexity of the loading conditions and device geometry, coupled with the nonlinear material behavior, may induce multi-axial and non-proportional deformation. Finite element analysis can assess the fatigue risk, by comparing the device state of stress with the material fatigue limit. The most suitable fatigue model is not fully understood for NiTi devices, due to its complex thermo-mechanical behavior. This paper assesses the fatigue behavior of NiTi stents through computational models and experimental validation. Four different strain-based models are considered: the von Mises criterion and three critical plane models (Fatemi-Socie, Brown-Miller, and Smith-Watson-Topper models). Two stents, made of the same material with different cell geometries are manufactured, and their fatigue behavior is experimentally characterized. The comparison between experimental and numerical results highlights an overestimation of the failure risk by the von Mises criterion. On the contrary, the selected critical plane models, even if based on different damage mechanisms, give a better fatigue life estimation. Further investigations on crack propagation mechanisms of NiTi stents are required to properly select the most reliable fatigue model.

  10. Dynamics of thin-film piezoelectric microactuators with large vertical stroke subject to multi-axis coupling and fabrication asymmetries

    Science.gov (United States)

    Choi, Jongsoo; Wang, Thomas; Oldham, Kenn

    2018-01-01

    The high performance and small size of MEMS based scanners has allowed various optical imaging techniques to be realized in a small form factor. Many such devices are resonant scanners, and thus their linear and nonlinear dynamic behaviors have been studied in the past. Thin-film piezoelectric materials, in contrast, provide sufficient energy density to achieve both large static displacements and high-frequency resonance, but large deformation can in turn influence dynamic scanner behavior. This paper reports on the influence of very large stroke translation of a piezoelectric vertical actuator on its resonant behavior, which may not be otherwise explained fully by common causes of resonance shift such as beam stiffening or nonlinear forcing. To examine the change of structural compliance over the course of scanner motion, a model has been developed that includes internal forces from residual stress and the resultant additional multi-axis coupling among actuator leg structures. Like some preceding vertical scanning micro-actuators, the scanner of this work has four legs, with each leg featuring four serially connected thin-film PZT unimorphs that allow the scanner to generate larger than 400 µm of vertical displacement at 14 V DC. Using an excitation near one or more resonances, the input voltage can be lowered, and complementary multi-axis rotations can be also generated, but change of the resonant frequencies with scanner height needs to be understood to maximize scanner performance. The presented model well predicts the experimental observation of the decrease of the resonant frequencies of the scanner with the increase of a dc bias voltage. Also, the effects of the magnitude and uniformity of residual stress across the scanner structure on the natural frequencies have been studied.

  11. Glutamatergic system abnormalities in posttraumatic stress disorder.

    Science.gov (United States)

    Nishi, Daisuke; Hashimoto, Kenji; Noguchi, Hiroko; Hamazaki, Kei; Hamazaki, Tomohito; Matsuoka, Yutaka

    2015-12-01

    Accumulating evidence suggests involvement of the glutamatergic system in the biological mechanisms of posttraumatic stress disorder (PTSD), but few studies have demonstrated an association between glutamatergic system abnormalities and PTSD diagnosis or severity. We aimed to examine whether abnormalities in serum glutamate and in the glutamine/glutamate ratio were associated with PTSD diagnosis and severity in severely injured patients at risk for PTSD and major depressive disorder (MDD). This is a nested case-control study in TPOP (Tachikawa project for prevention of posttraumatic stress disorder with polyunsaturated fatty acid) trial. Diagnosis and severity of PTSD were assessed 3 months after the accidents using the Clinician-Administered PTSD Scale. The associations of glutamate levels and the glutamine/glutamate ratio with diagnosis and severity of PTSD and MDD were investigated by univariate and multiple linear regression analyses. Ninety-seven of 110 participants (88 %) completed assessments at 3 months. Serum glutamate levels were significantly higher for participants with full or partial PTSD than for participants without PTSD (p = 0.049) and for participants with MDD than for participants without MDD (p = 0.048). Multiple linear regression analyses showed serum glutamate levels were significantly positively associated with PTSD severity (p = 0.02) and MDD severity (p = 0.03). The glutamine/glutamate ratio was also significantly inversely associated with PTSD severity (p = 0.03), but not with MDD severity (p = 0.07). These findings suggest that the glutamatergic system may play a major role in the pathogenesis of PTSD and the need for new treatments targeting the glutamatergic system to be developed for PTSD.

  12. Motion sickness, stress and the endocannabinoid system.

    Directory of Open Access Journals (Sweden)

    Alexander Choukèr

    Full Text Available BACKGROUND: A substantial number of individuals are at risk for the development of motion sickness induced nausea and vomiting (N&V during road, air or sea travel. Motion sickness can be extremely stressful but the neurobiologic mechanisms leading to motion sickness are not clear. The endocannabinoid system (ECS represents an important neuromodulator of stress and N&V. Inhibitory effects of the ECS on N&V are mediated by endocannabinoid-receptor activation. METHODOLOGY/PRINCIPAL FINDINGS: We studied the activity of the ECS in human volunteers (n = 21 during parabolic flight maneuvers (PFs. During PFs, microgravity conditions (<10(-2 g are generated for approximately 22 s which results in a profound kinetic stimulus. Blood endocannabinoids (anandamide and 2-arachidonoylglycerol, 2-AG were measured from blood samples taken in-flight before start of the parabolic maneuvers, after 10, 20, and 30 parabolas, in-flight after termination of PFs and 24 h later. Volunteers who developed acute motion sickness (n = 7 showed significantly higher stress scores but lower endocannabinoid levels during PFs. After 20 parabolas, blood anandamide levels had dropped significantly in volunteers with motion sickness (from 0.39+/-0.40 to 0.22+/-0.25 ng/ml but increased in participants without the condition (from 0.43+/-0.23 to 0.60+/-0.38 ng/ml resulting in significantly higher anandamide levels in participants without motion sickness (p = 0.02. 2-AG levels in individuals with motion sickness were low and almost unchanged throughout the experiment but showed a robust increase in participants without motion sickness. Cannabinoid-receptor 1 (CB1 but not cannabinoid-receptor 2 (CB2 mRNA expression in leucocytes 4 h after the experiment was significantly lower in volunteers with motion sickness than in participants without N&V. CONCLUSIONS/SIGNIFICANCE: These findings demonstrate that stress and motion sickness in humans are associated with impaired endocannabinoid

  13. Coverage of multiaxial fatigue criteria in fatigue limit region

    Directory of Open Access Journals (Sweden)

    Papuga J.

    2007-11-01

    Full Text Available There is a power of methods aimed at calculation of equivalent fatigue limit for arbitrary multiaxial loading. Although there are so many ways of computation, their thorough mutual comparison in a larger scale is missing. The database project presented in this paper comprise of several databases crowned with the FatLim database, which comprise of a huge number of experimental results and of 18 computational method working in the category mentioned before. The great block of data was acquired using in-house fatigue software PragTic, which is offered as a freeware application. The FatLim database follows its philosophy of a simple and non-paid accessibility. Its query tool written in MySQL and PhP allows to users to evaluate a practical usability of tested methods on load cases, which the users define. All the issues covered within this paper are available on the website www.pragtic.com, structure of which is described here.

  14. PRIGo: a new multi-axis goniometer for macromolecular crystallography

    Energy Technology Data Exchange (ETDEWEB)

    Waltersperger, Sandro; Olieric, Vincent, E-mail: vincent.olieric@psi.ch; Pradervand, Claude [Paul Scherrer Institute, Villigen PSI (Switzerland); Glettig, Wayne [Centre Suisse d’Electronique et Microtechnique SA, Neuchâtel 2002 (Switzerland); Salathe, Marco; Fuchs, Martin R.; Curtin, Adrian; Wang, Xiaoqiang; Ebner, Simon; Panepucci, Ezequiel; Weinert, Tobias [Paul Scherrer Institute, Villigen PSI (Switzerland); Schulze-Briese, Clemens [Dectris Ltd, Baden 5400 (Switzerland); Wang, Meitian, E-mail: vincent.olieric@psi.ch [Paul Scherrer Institute, Villigen PSI (Switzerland)

    2015-05-09

    The design and performance of the new multi-axis goniometer PRIGo developed at the Swiss Light Source at Paul Scherrer Institute is described. The Parallel Robotics Inspired Goniometer (PRIGo) is a novel compact and high-precision goniometer providing an alternative to (mini-)kappa, traditional three-circle goniometers and Eulerian cradles used for sample reorientation in macromolecular crystallography. Based on a combination of serial and parallel kinematics, PRIGo emulates an arc. It is mounted on an air-bearing stage for rotation around ω and consists of four linear positioners working synchronously to achieve x, y, z translations and χ rotation (0–90°), followed by a ϕ stage (0–360°) for rotation around the sample holder axis. Owing to the use of piezo linear positioners and active correction, PRIGo features spheres of confusion of <1 µm, <7 µm and <10 µm for ω, χ and ϕ, respectively, and is therefore very well suited for micro-crystallography. PRIGo enables optimal strategies for both native and experimental phasing crystallographic data collection. Herein, PRIGo hardware and software, its calibration, as well as applications in macromolecular crystallography are described.

  15. Residual stresses in plastic random systems

    NARCIS (Netherlands)

    Alava, M.J.; Karttunen, M.E.J.; Niskanen, K.J.

    1995-01-01

    We show that yielding in elastic plastic materials creates residual stresses when local disorder is present. The intensity of these stresses grows with the external stress and degree of initial disorder. The one-dimensional model we employ also yields a discontinuous transition to perfect plasticity

  16. Studying prepulse inhibition in a stressed system

    NARCIS (Netherlands)

    Douma, T.N.

    2013-01-01

    Onset and course of psychotic disorders are thought to be influenced by stress, although there is no consistent evidence that experience of elevated levels of stress triggers disease onset in healthy individuals. In order to better understand the relation between stress and psychosis, these complex

  17. Design and implementation of a multiaxial loading capability during heating on an engineering neutron diffractometer

    International Nuclear Information System (INIS)

    Benafan, O.; Padula, S. A.; Skorpenske, H. D.; An, K.; Vaidyanathan, R.

    2014-01-01

    A gripping capability was designed, implemented, and tested for in situ neutron diffraction measurements during multiaxial loading and heating on the VULCAN engineering materials diffractometer at the spallation neutron source at Oak Ridge National Laboratory. The proposed capability allowed for the acquisition of neutron spectra during tension, compression, torsion, and/or complex loading paths at elevated temperatures. The design consisted of age-hardened, Inconel ® 718 grips with direct attachment to the existing MTS load frame having axial and torsional capacities of 100 kN and 400 N·m, respectively. Internal cooling passages were incorporated into the gripping system for fast cooling rates during high temperature experiments up to ∼1000 K. The specimen mounting couplers combined a threaded and hexed end-connection for ease of sample installation/removal without introducing any unwanted loads. Instrumentation of this capability is documented in this work along with various performance parameters. The gripping system was utilized to investigate deformation in NiTi shape memory alloys under various loading/control modes (e.g., isothermal, isobaric, and cyclic), and preliminary results are presented. The measurements facilitated the quantification of the texture, internal strain, and phase fraction evolution in NiTi shape memory alloys under various loading/control modes

  18. Design and implementation of a multiaxial loading capability during heating on an engineering neutron diffractometer

    Energy Technology Data Exchange (ETDEWEB)

    Benafan, O., E-mail: othmane.benafan@nasa.gov [NASA Glenn Research Center, Structures and Materials Division, Cleveland, Ohio 44135 (United States); Advanced Materials Processing and Analysis Center, Materials Science and Engineering Department, University of Central Florida, Orlando, Florida 32816 (United States); Padula, S. A. [NASA Glenn Research Center, Structures and Materials Division, Cleveland, Ohio 44135 (United States); Skorpenske, H. D.; An, K. [Spallation Neutron Source, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831 (United States); Vaidyanathan, R. [Advanced Materials Processing and Analysis Center, Materials Science and Engineering Department, University of Central Florida, Orlando, Florida 32816 (United States)

    2014-10-01

    A gripping capability was designed, implemented, and tested for in situ neutron diffraction measurements during multiaxial loading and heating on the VULCAN engineering materials diffractometer at the spallation neutron source at Oak Ridge National Laboratory. The proposed capability allowed for the acquisition of neutron spectra during tension, compression, torsion, and/or complex loading paths at elevated temperatures. The design consisted of age-hardened, Inconel{sup ®} 718 grips with direct attachment to the existing MTS load frame having axial and torsional capacities of 100 kN and 400 N·m, respectively. Internal cooling passages were incorporated into the gripping system for fast cooling rates during high temperature experiments up to ~1000 K. The specimen mounting couplers combined a threaded and hexed end-connection for ease of sample installation/removal without introducing any unwanted loads. Instrumentation of this capability is documented in this work along with various performance parameters. The gripping system was utilized to investigate deformation in NiTi shape memory alloys under various loading/control modes (e.g., isothermal, isobaric, and cyclic), and preliminary results are presented. The measurements facilitated the quantification of the texture, internal strain, and phase fraction evolution in NiTi shape memory alloys under various loading/control modes.

  19. Multi-Axis Force Sensor for Human-Robot Interaction Sensing in a Rehabilitation Robotic Device.

    Science.gov (United States)

    Grosu, Victor; Grosu, Svetlana; Vanderborght, Bram; Lefeber, Dirk; Rodriguez-Guerrero, Carlos

    2017-06-05

    Human-robot interaction sensing is a compulsory feature in modern robotic systems where direct contact or close collaboration is desired. Rehabilitation and assistive robotics are fields where interaction forces are required for both safety and increased control performance of the device with a more comfortable experience for the user. In order to provide an efficient interaction feedback between the user and rehabilitation device, high performance sensing units are demanded. This work introduces a novel design of a multi-axis force sensor dedicated for measuring pelvis interaction forces in a rehabilitation exoskeleton device. The sensor is conceived such that it has different sensitivity characteristics for the three axes of interest having also movable parts in order to allow free rotations and limit crosstalk errors. Integrated sensor electronics make it easy to acquire and process data for a real-time distributed system architecture. Two of the developed sensors are integrated and tested in a complex gait rehabilitation device for safe and compliant control.

  20. Developing Parametric Models for the Assembly of Machine Fixtures for Virtual Multiaxial CNC Machining Centers

    Science.gov (United States)

    Balaykin, A. V.; Bezsonov, K. A.; Nekhoroshev, M. V.; Shulepov, A. P.

    2018-01-01

    This paper dwells upon a variance parameterization method. Variance or dimensional parameterization is based on sketching, with various parametric links superimposed on the sketch objects and user-imposed constraints in the form of an equation system that determines the parametric dependencies. This method is fully integrated in a top-down design methodology to enable the creation of multi-variant and flexible fixture assembly models, as all the modeling operations are hierarchically linked in the built tree. In this research the authors consider a parameterization method of machine tooling used for manufacturing parts using multiaxial CNC machining centers in the real manufacturing process. The developed method allows to significantly reduce tooling design time when making changes of a part’s geometric parameters. The method can also reduce time for designing and engineering preproduction, in particular, for development of control programs for CNC equipment and control and measuring machines, automate the release of design and engineering documentation. Variance parameterization helps to optimize construction of parts as well as machine tooling using integrated CAE systems. In the framework of this study, the authors demonstrate a comprehensive approach to parametric modeling of machine tooling in the CAD package used in the real manufacturing process of aircraft engines.

  1. Spatial reliability analysis of a wind turbine blade cross section subjected to multi-axial extreme loading

    DEFF Research Database (Denmark)

    Dimitrov, Nikolay Krasimirov; Bitsche, Robert; Blasques, José Pedro Albergaria Amaral

    2017-01-01

    This paper presents a methodology for structural reliability analysis of wind turbine blades. The study introduces several novel elements by taking into account loading direction using a multiaxial probabilistic load model, considering random material strength, spatial correlation between material...... properties, progressive material failure, and system reliability effects. An example analysis of reliability against material failure is demonstrated for a blade cross section. Based on the study we discuss the implications of using a system reliability approach, the effect of spatial correlation length......, type of material degradation algorithm, and reliability methods on the system failure probability, as well as the main factors that have an influence on the reliability. (C) 2017 Elsevier Ltd. All rights reserved....

  2. ALLTEM Multi-Axis Electromagnetic Induction System Demonstration and Validation

    Science.gov (United States)

    2011-11-17

    8217/ SAM /’/ 0. 100 -~==;;;:~~~;~~~~~~i~~~~~~~§~~~~~~~~~~~~~ SPM /’/ O.OSO+ SPM 1) ~ 9PM /’/ ~ O.OOO -~ lOAM "’ "’ 0 > "’ "’ 0 > .O . OSO ...1) ~ 9PM /V ~ o.ooo -IP’ lOAM .o . oso -r-------------------------------------t,.~IO!P~M_l/V~]J .O. l00 -~---------------------------------------1

  3. Quality of Financial Policies and Financial System Stress

    OpenAIRE

    Udaibir S Das; Plamen Yossifov; Richard Podpiera; Dmitriy L Rozhkov

    2005-01-01

    In this paper, we develop multi-country indices of financial system stress and quality of financial policies and use them in regression analysis of the determinants of financial stress. We find that countries with higher quality of financial policies are better able to contain the effects of macroeconomic pressures on the overall level of stress in the financial system. They are also in a better position to ensure sustainable development of the financial system.

  4. Multiaxial fatigue criteria for AISI 304 and 2-1/4 Cr-1 Mo steel at 5380C with applications to strain-range partitioning and linear summation of creep and fatigue damage

    International Nuclear Information System (INIS)

    Blass, J.J.

    1982-01-01

    An improved multiaxial fatigue failure criterion was developed based on the results of combined axial-torsional strain cycling tests of AISI 304 and 2-1/4 Cr-1 Mo steel conducted at 538 0 C (1000 0 F). The formulation of this criterion involves the shear and normal components of inelastic strain range on the planes of maximum inelastic shear strain range. Optimum values of certain parameters contained in the formulation were obtained for each material by the method of least squares. The ability of this criterion to correlate the test results was compared with that of the usual (Mises) equivalent inelastic strain range criterion. An improved definition of equivalent inelastic strain range resulting from these considerations was used to generalize the theory of Strain Range Partitioning to multiaxial stress-strain conditions and was also applied to the linear summation of creep and fatigue damage

  5. Neurobiological Interactions Between Stress and the Endocannabinoid System.

    Science.gov (United States)

    Morena, Maria; Patel, Sachin; Bains, Jaideep S; Hill, Matthew N

    2016-01-01

    Stress affects a constellation of physiological systems in the body and evokes a rapid shift in many neurobehavioral processes. A growing body of work indicates that the endocannabinoid (eCB) system is an integral regulator of the stress response. In the current review, we discuss the evidence to date that demonstrates stress-induced regulation of eCB signaling and the consequential role changes in eCB signaling have with respect to many of the effects of stress. Across a wide array of stress paradigms, studies have generally shown that stress evokes bidirectional changes in the two eCB molecules, anandamide (AEA) and 2-arachidonoyl glycerol (2-AG), with stress exposure reducing AEA levels and increasing 2-AG levels. Additionally, in almost every brain region examined, exposure to chronic stress reliably causes a downregulation or loss of cannabinoid type 1 (CB1) receptors. With respect to the functional role of changes in eCB signaling during stress, studies have demonstrated that the decline in AEA appears to contribute to the manifestation of the stress response, including activation of the hypothalamic-pituitary-adrenal (HPA) axis and increases in anxiety behavior, while the increased 2-AG signaling contributes to termination and adaptation of the HPA axis, as well as potentially contributing to changes in pain perception, memory and synaptic plasticity. More so, translational studies have shown that eCB signaling in humans regulates many of the same domains and appears to be a critical component of stress regulation, and impairments in this system may be involved in the vulnerability to stress-related psychiatric conditions, such as depression and posttraumatic stress disorder. Collectively, these data create a compelling argument that eCB signaling is an important regulatory system in the brain that largely functions to buffer against many of the effects of stress and that dynamic changes in this system contribute to different aspects of the stress response.

  6. Evaluation of the Stress Resilience Training System

    Science.gov (United States)

    2014-10-30

    burnout were assessed before and after an eight week training period. Significant improvement in overall stress was observed; however, there were no...significantly based on location, role, and mission. Regardless of cause, the accumulation of stress over time can lead to burnout (Taris, LeBlanc, Schaufeli...such as hospital floor nurses (28%). 5.4 Post-Traumatic Stress The PTSD Checklist, military version (PCL-M) results indicated that 1 participant (4

  7. Multiaxial brittle failure of a 3D carbon-carbon composite

    International Nuclear Information System (INIS)

    Davy, Catherine

    2001-01-01

    Several industrial equipments, for example in aeronautics, civil or military nuclear applications, imply multi-axially loaded brittle materials for which reliable failure models are needed. In that context, our study focuses on a 3D carbon-carbon composite submitted in service to a triaxial strain state along its orthotropy axes. A failure criterion based on a bibliographical analysis is identified thanks to uniaxial tensile tests, and validated through an original multiaxial experiment. The scatter on its failure characteristics is also identified. (author) [fr

  8. Hot weather stresses system : more supply needed

    International Nuclear Information System (INIS)

    Anon

    2002-01-01

    Signs of stress in Ontario's electric system were revealed this summer, mainly as a result of the hot and humid weather experienced in the Toronto region in particular. A question was raised by the Executive Director of the Independent Power Producers' Society of Ontario (IPPSO) as to whether there are enough incentives for new supply or any unnecessary barriers, in light of the tight reserve margins and little new construction. No major failures or breakdowns were experienced, which proved to be a real test of the newly created market system. However, significant spikes in hourly prices and uplift charges were felt in July. At times, power had to be purchased from outside the province, and the prices paid for this power were much higher than the prices paid to in-province producers. There was proof that consumers were not adjusting their consumption in response to fluctuations in the prices, as had been expected by the system's designers. Pre-dispatch and real-time prices were disconnected, and large consumers did not benefit from reliable day-ahead price projections. Another major issue raised was that of finding new power supplies. The situation is not yet desperate as Ontario can trade electricity with other regions, but it is felt that the situation should be examined sooner rather than later. Import pricing is an issue that needs to be addressed now. The IPPSO is concerned that no new generating capacity plans are in the works at this time. The barriers to new investment in Ontario's generation must be identified, and a meeting between market participants and government should be scheduled for that purpose. A review of the presentation of price-related information is being conducted to allow consumers to adjust their consumption, cutting back when prices soar and saving money by the same token. It is felt that a more comfortable surplus of supply would either reduce or eliminate these problems. Some of the reasons believed to affect the level of investment in

  9. Hot weather stresses system : more supply needed

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2002-08-01

    Signs of stress in Ontario's electric system were revealed this summer, mainly as a result of the hot and humid weather experienced in the Toronto region in particular. A question was raised by the Executive Director of the Independent Power Producers' Society of Ontario (IPPSO) as to whether there are enough incentives for new supply or any unnecessary barriers, in light of the tight reserve margins and little new construction. No major failures or breakdowns were experienced, which proved to be a real test of the newly created market system. However, significant spikes in hourly prices and uplift charges were felt in July. At times, power had to be purchased from outside the province, and the prices paid for this power were much higher than the prices paid to in-province producers. There was proof that consumers were not adjusting their consumption in response to fluctuations in the prices, as had been expected by the system's designers. Pre-dispatch and real-time prices were disconnected, and large consumers did not benefit from reliable day-ahead price projections. Another major issue raised was that of finding new power supplies. The situation is not yet desperate as Ontario can trade electricity with other regions, but it is felt that the situation should be examined sooner rather than later. Import pricing is an issue that needs to be addressed now. The IPPSO is concerned that no new generating capacity plans are in the works at this time. The barriers to new investment in Ontario's generation must be identified, and a meeting between market participants and government should be scheduled for that purpose. A review of the presentation of price-related information is being conducted to allow consumers to adjust their consumption, cutting back when prices soar and saving money by the same token. It is felt that a more comfortable surplus of supply would either reduce or eliminate these problems. Some of the reasons believed to affect the

  10. Individualized Stress Detection System, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Given the extended duration of future missions and the isolated, extreme, and confined environments, there is the possibility that stress-related behavioral...

  11. Individualized Stress Detection System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Given the extended duration of future missions and the isolated, extreme and confined environments, there is the possibility that stress-related behavioral...

  12. Model-based framework for multi-axial real-time hybrid simulation testing

    Science.gov (United States)

    Fermandois, Gaston A.; Spencer, Billie F.

    2017-10-01

    Real-time hybrid simulation is an efficient and cost-effective dynamic testing technique for performance evaluation of structural systems subjected to earthquake loading with rate-dependent behavior. A loading assembly with multiple actuators is required to impose realistic boundary conditions on physical specimens. However, such a testing system is expected to exhibit significant dynamic coupling of the actuators and suffer from time lags that are associated with the dynamics of the servo-hydraulic system, as well as control-structure interaction (CSI). One approach to reducing experimental errors considers a multi-input, multi-output (MIMO) controller design, yielding accurate reference tracking and noise rejection. In this paper, a framework for multi-axial real-time hybrid simulation (maRTHS) testing is presented. The methodology employs a real-time feedback-feedforward controller for multiple actuators commanded in Cartesian coordinates. Kinematic transformations between actuator space and Cartesian space are derived for all six-degrees-offreedom of the moving platform. Then, a frequency domain identification technique is used to develop an accurate MIMO transfer function of the system. Further, a Cartesian-domain model-based feedforward-feedback controller is implemented for time lag compensation and to increase the robustness of the reference tracking for given model uncertainty. The framework is implemented using the 1/5th-scale Load and Boundary Condition Box (LBCB) located at the University of Illinois at Urbana- Champaign. To demonstrate the efficacy of the proposed methodology, a single-story frame subjected to earthquake loading is tested. One of the columns in the frame is represented physically in the laboratory as a cantilevered steel column. For realtime execution, the numerical substructure, kinematic transformations, and controllers are implemented on a digital signal processor. Results show excellent performance of the maRTHS framework when six

  13. Stress and multiple memory systems: from 'thinking' to 'doing'.

    Science.gov (United States)

    Schwabe, Lars; Wolf, Oliver T

    2013-02-01

    Although it has been known for decades that stress influences memory performance, it was only recently shown that stress may alter the contribution of multiple, anatomically and functionally distinct memory systems to behavior. Here, we review recent animal and human studies demonstrating that stress promotes a shift from flexible 'cognitive' to rather rigid 'habit' memory systems and discuss, based on recent neuroimaging data in humans, the underlying brain mechanisms. We argue that, despite being generally adaptive, this stress-induced shift towards 'habit' memory may, in vulnerable individuals, be a risk factor for psychopathology. Copyright © 2012 Elsevier Ltd. All rights reserved.

  14. Multiaxial fatigue of cast aluminium EN AC-42000 T6 (G-AlSi7Mg0.3 T6 for automotive safety components under constant and variable amplitude loading

    Directory of Open Access Journals (Sweden)

    C.M. Sonsino

    2016-07-01

    Full Text Available Regarding the fatigue behaviour of EN AC-42000 T6 (A 356 T6, which is the most frequently used cast aluminium alloy for automotive safety components, especially under non-proportional constant and variable normal and shear stress amplitudes with changing principal stress directions, a poor level of knowledge was available. The reported investigations show that, under non-proportional normal and shear stresses, fatigue life is increased in contrast to ductile steels where life is reduced due to changing principal stress directions. This behaviour caused by the low ductility of this alloy (e < 10% compared to quenched and tempered steels suggests the application of the Normal (Principal Stress Hypothesis (NSH. For all of the investigated stress states under multiaxial constant and variable (Gaussian spectrum amplitudes without and with mean stresses, the NSH was able to depict the life increase by the non-proportionality and delivered, for most cases, conservative but non-exaggerated results.

  15. Plant Core Environmental Stress Response Genes Are Systemically Coordinated during Abiotic Stresses

    Directory of Open Access Journals (Sweden)

    Kenneth W. Berendzen

    2013-04-01

    Full Text Available Studying plant stress responses is an important issue in a world threatened by global warming. Unfortunately, comparative analyses are hampered by varying experimental setups. In contrast, the AtGenExpress abiotic stress experiment displays intercomparability. Importantly, six of the nine stresses (wounding, genotoxic, oxidative, UV-B light, osmotic and salt can be examined for their capacity to generate systemic signals between the shoot and root, which might be essential to regain homeostasis in Arabidopsis thaliana. We classified the systemic responses into two groups: genes that are regulated in the non-treated tissue only are defined as type I responsive and, accordingly, genes that react in both tissues are termed type II responsive. Analysis of type I and II systemic responses suggest distinct functionalities, but also significant overlap between different stresses. Comparison with salicylic acid (SA and methyl-jasmonate (MeJA responsive genes implies that MeJA is involved in the systemic stress response. Certain genes are predominantly responding in only one of the categories, e.g., WRKY genes respond mainly non-systemically. Instead, genes of the plant core environmental stress response (PCESR, e.g., ZAT10, ZAT12, ERD9 or MES9, are part of different response types. Moreover, several PCESR genes switch between the categories in a stress-specific manner.

  16. Thermal isocreep curves obtained during multi-axial creep tests on recrystallized Zircaloy-4 and M5™ alloy

    International Nuclear Information System (INIS)

    Rautenberg, M.; Poquillon, D.; Pilvin, P.; Grosjean, C.; Cloué, J.M.; Feaugas, X.

    2014-01-01

    Zirconium alloys are widely used in the nuclear industry. Several components, such as cladding or guide tubes, undergo strong mechanical loading during and after their use inside the pressurized water reactors. The current requirements on higher fuel performances lead to the developing on new Zr based alloys exhibiting better mechanical properties. In this framework, creep behaviors of recrystallized Zircaloy-4 and M5™, have been investigated and then compared. In order to give a better understanding of the thermal creep anisotropy of Zr-based alloys, multi-axial creep tests have been carried out at 673 K. Using a specific device, creep conditions have been set using different values of β = σ zz /σ θθ , σ zz and σ θθ being respectively the axial and hoop creep stresses. Both axial and hoop strains are measured during each test which is carried out until stationary creep is stabilized. The steady-state strain rates are then used to build isocreep curves. Considering the isocreep curves, the M5™ alloy shows a largely improved creep resistance compared to the recrystallized Zircaloy-4, especially for tubes under high hoop loadings (0 < β < 1). The isocreep curves are then compared with simulations performed using two different mechanical models. Model 1 uses a von Mises yield criterion, the model 2 is based on a Hill yield criterion. For both models, a coefficient derived from Norton law is used to assess the stress dependence

  17. Stress-oriented driver assistance system for electric vehicles.

    Science.gov (United States)

    Athanasiou, Georgia; Tsotoulidis, Savvas; Mitronikas, Epaminondas; Lymberopoulos, Dimitrios

    2014-01-01

    Stress is physiological and physical reaction that appears in highly demanding situations and affects human's perception and reaction capability. Occurrence of stress events within highly dynamic road environment could lead to life-threatening situation. With the perspective of safety and comfort driving provision to anxious drivers, in this paper a stress-oriented Driver Assistance System (DAS) is proposed. The DAS deployed on Electric Vehicle. This novel DAS customizes driving command signal in respect to road context, when stress is detected. The effectiveness of this novel DAS is verified by simulation in MATLAB/SIMULINK environment.

  18. Restricted and disrupted sleep : Effects on autonomic function, neuroendocrine stress systems and stress responsivity

    NARCIS (Netherlands)

    Meerlo, Peter; Sgoifo, Andrea; Suchecki, Deborah

    2008-01-01

    Frequently disrupted and restricted sleep is a common problem for many people in our modern around-the-clock society. In this context, it is an important question how sleep loss affects the stress systems in our bodies since these systems enable us to deal with everyday challenges. Altered activity

  19. A multimodal stress monitoring system with canonical correlation analysis.

    Science.gov (United States)

    Unsoo Ha; Changhyeon Kim; Yongsu Lee; Hyunki Kim; Taehwan Roh; Hoi-Jun Yoo

    2015-08-01

    The multimodal stress monitoring headband is proposed for mobile stress management system. It is composed of headband and earplugs. Electroencephalography (EEG), hemoencephalography (HEG) and heart-rate variability (HRV) can be achieved simultaneously in the proposed system for user status estimation. With canonical correlation analysis (CCA) and temporal-kernel CCA (tkCCA) algorithm, those different signals can be combined for maximum correlation. Thanks to the proposed combination algorithm, the accuracy of the proposed system increased up to 19 percentage points than unimodal monitoring system in n-back task.

  20. Formation and Use of Stress Management Systems in Enterprises

    Directory of Open Access Journals (Sweden)

    Honchar Mykhailo F.

    2017-12-01

    Full Text Available In the article there developed a typology of factors of forming and using stress management systems in enterprises that implies their division into factors of direct and indirect impact. The first group includes the factor of the management system as a whole, competence of the staff, information support, goals and tasks of stress management, temporary orientation of systems of stress management and its object. In turn, the factors of indirect impact include the level and scale of the enterprise’s activities, stability of the functioning environment, organizational culture, psychological management features, organizational communications, stakeholder interests, social responsibility, and corporate image. Knowledge and understanding of such factors contributes to a more thorough diagnosis of processes within these systems, as well as selection of an adequate model of managerial behavior. In addition, the results provide an opportunity to optimize the parameters of stress management systems based on identification of the level of influence of each of these factors. It is concluded that most of the factors in forming and using stress management systems in enterprises are those that are purposefully exposed to influence on the part of the organization, for example, by making decisions, attracting additional resources, increasing the competence of the staff, reviewing the terms of contracts with partners, changing methods of performing work, etc. This is due to the fact that most of the factors considered are factors of the internal environment.

  1. Role of sulfiredoxin in systemic diseases influenced by oxidative stress

    Directory of Open Access Journals (Sweden)

    Asha Ramesh

    2014-01-01

    Full Text Available Sulfiredoxin is a recently discovered member of the oxidoreductases family which plays a crucial role in thiol homoeostasis when under oxidative stress. A myriad of systemic disorders have oxidative stress and reactive oxygen species as the key components in their etiopathogenesis. Recent studies have evaluated the role of this enzyme in oxidative stress mediated diseases such as atherosclerosis, chronic obstructive pulmonary disease and a wide array of carcinomas. Its action is responsible for the normal functioning of cells under oxidative stress and the promotion of cell survival in cancerous cells. This review will highlight the cumulative effects of sulfiredoxin in various systemic disorders with a strong emphasis on its target activity and the factors influencing its expression in such conditions.

  2. Stress Biomarkers in Vanaraja Chicken Maintained Under Various Rearing Systems

    Directory of Open Access Journals (Sweden)

    Pawan K. Verma

    2012-01-01

    Full Text Available Stress is of major concern for poultry industry because it exerts deleterious effects on different parameters like feed intake, feed conversion ratio, weight gain, etc. In present study various enzymatic viz. superoxide dismutase (SOD, catalase (CAT, glutathione peroxidase (GSH-Px and non-enzymatic components like reduced glutathione (GSH, hemoglobin and stress induced cellular damage i.e. lipid peroxidation was estimated to access the stress level in Vanaraja chickens reared under various rearing systems during summer. Significantly (p<0.05 increased activities of CAT and SOD was observed in deep litter system as compared to cage and semi-intensive rearing system. However, non-significant change in CAT and significantly increased activity of SOD was observed as the age progress. GSH-Px activity significantly lower (p<0.05 in the deep litter as compared to other systems, however, the activity increases significantly (p<0.05 at 8th wks as compared to 4th wks. GSH level was found maximum in cage system compared to deep litter and semi-intensive system. Non-significant changes were observed in hemoglobin concentration during study both between age groups as well as the age progresses. Observations of the study suggested that cage system is better than deep litter and semi-intensive system in handling the stress induced by different environmental factors.

  3. Stress Testing of Transactional Database Systems

    OpenAIRE

    Meira , Jorge Augusto; Cunha De Almeida , Eduardo; Sunyé , Gerson; Le Traon , Yves; Valduriez , Patrick

    2013-01-01

    International audience; Transactional database management systems (DBMS) have been successful at supporting traditional transaction processing workloads. However, web-based applications that tend to generate huge numbers of concurrent business operations are pushing DBMS performance over their limits, thus threatening overall system availability. Then, a crucial question is how to test DBMS performance under heavy workload conditions. Answering this question requires a testing methodology to ...

  4. Hybrid analysis of multiaxis electromagnetic data for discrimination of munitions and explosives of concern

    Science.gov (United States)

    Friedel, M. J.; Asch, T. H.; Oden, C.

    2012-08-01

    The remediation of land containing munitions and explosives of concern, otherwise known as unexploded ordnance, is an ongoing problem facing the U.S. Department of Defense and similar agencies worldwide that have used or are transferring training ranges or munitions disposal areas to civilian control. The expense associated with cleanup of land previously used for military training and war provides impetus for research towards enhanced discrimination of buried unexploded ordnance. Towards reducing that expense, a multiaxis electromagnetic induction data collection and software system, called ALLTEM, was designed and tested with support from the U.S. Department of Defense Environmental Security Technology Certification Program. ALLTEM is an on-time time-domain system that uses a continuous triangle-wave excitation to measure the target-step response rather than traditional impulse response. The system cycles through three orthogonal transmitting loops and records a total of 19 different transmitting and receiving loop combinations with a nominal spatial data sampling interval of 20 cm. Recorded data are pre-processed and then used in a hybrid discrimination scheme involving both data-driven and numerical classification techniques. The data-driven classification scheme is accomplished in three steps. First, field observations are used to train a type of unsupervised artificial neural network, a self-organizing map (SOM). Second, the SOM is used to simultaneously estimate target parameters (depth, azimuth, inclination, item type and weight) by iterative minimization of the topographic error vectors. Third, the target classification is accomplished by evaluating histograms of the estimated parameters. The numerical classification scheme is also accomplished in three steps. First, the Biot-Savart law is used to model the primary magnetic fields from the transmitter coils and the secondary magnetic fields generated by currents induced in the target materials in the

  5. Hybrid analysis of multiaxis electromagnetic data for discrimination of munitions and explosives of concern

    Science.gov (United States)

    Friedel, M.J.; Asch, T.H.; Oden, C.

    2012-01-01

    The remediation of land containing munitions and explosives of concern, otherwise known as unexploded ordnance, is an ongoing problem facing the U.S. Department of Defense and similar agencies worldwide that have used or are transferring training ranges or munitions disposal areas to civilian control. The expense associated with cleanup of land previously used for military training and war provides impetus for research towards enhanced discrimination of buried unexploded ordnance. Towards reducing that expense, a multiaxis electromagnetic induction data collection and software system, called ALLTEM, was designed and tested with support from the U.S. Department of Defense Environmental Security Technology Certification Program. ALLTEM is an on-time time-domain system that uses a continuous triangle-wave excitation to measure the target-step response rather than traditional impulse response. The system cycles through three orthogonal transmitting loops and records a total of 19 different transmitting and receiving loop combinations with a nominal spatial data sampling interval of 20 cm. Recorded data are pre-processed and then used in a hybrid discrimination scheme involving both data-driven and numerical classification techniques. The data-driven classification scheme is accomplished in three steps. First, field observations are used to train a type of unsupervised artificial neural network, a self-organizing map (SOM). Second, the SOM is used to simultaneously estimate target parameters (depth, azimuth, inclination, item type and weight) by iterative minimization of the topographic error vectors. Third, the target classification is accomplished by evaluating histograms of the estimated parameters. The numerical classification scheme is also accomplished in three steps. First, the Biot–Savart law is used to model the primary magnetic fields from the transmitter coils and the secondary magnetic fields generated by currents induced in the target materials in the

  6. Catecholaminergic systems in stress: structural and molecular genetic approaches.

    Science.gov (United States)

    Kvetnansky, Richard; Sabban, Esther L; Palkovits, Miklos

    2009-04-01

    Stressful stimuli evoke complex endocrine, autonomic, and behavioral responses that are extremely variable and specific depending on the type and nature of the stressors. We first provide a short overview of physiology, biochemistry, and molecular genetics of sympatho-adrenomedullary, sympatho-neural, and brain catecholaminergic systems. Important processes of catecholamine biosynthesis, storage, release, secretion, uptake, reuptake, degradation, and transporters in acutely or chronically stressed organisms are described. We emphasize the structural variability of catecholamine systems and the molecular genetics of enzymes involved in biosynthesis and degradation of catecholamines and transporters. Characterization of enzyme gene promoters, transcriptional and posttranscriptional mechanisms, transcription factors, gene expression and protein translation, as well as different phases of stress-activated transcription and quantitative determination of mRNA levels in stressed organisms are discussed. Data from catecholamine enzyme gene knockout mice are shown. Interaction of catecholaminergic systems with other neurotransmitter and hormonal systems are discussed. We describe the effects of homotypic and heterotypic stressors, adaptation and maladaptation of the organism, and the specificity of stressors (physical, emotional, metabolic, etc.) on activation of catecholaminergic systems at all levels from plasma catecholamines to gene expression of catecholamine enzymes. We also discuss cross-adaptation and the effect of novel heterotypic stressors on organisms adapted to long-term monotypic stressors. The extra-adrenal nonneuronal adrenergic system is described. Stress-related central neuronal regulatory circuits and central organization of responses to various stressors are presented with selected examples of regulatory molecular mechanisms. Data summarized here indicate that catecholaminergic systems are activated in different ways following exposure to distinct

  7. Biaxial nominal state of stress at the crack front

    International Nuclear Information System (INIS)

    Dietmann, H.; Kussmaul, K.

    1979-01-01

    In fracture toughness testing with CT-specimens there is an unaxial nominal stress state caused by the nominal stress psub(y) perpendicular to the crack surface. This paper investigates the question whether the fracture toughness, or generally speaking, the fracture load, is influenced by additional nominal stresses psub(x) and psub(z) in the crack surface, i.e. by a multiaxial stress state. (orig.)

  8. Phosphate-dependent root system architecture responses to salt stress

    KAUST Repository

    Kawa, Dorota; Julkowska, Magdalena; Montero Sommerfeld, Hector; Horst, Anneliek ter; Haring, Michel A; Testerink, Christa

    2016-01-01

    Nutrient availability and salinity of the soil affect growth and development of plant roots. Here, we describe how phosphate availability affects root system architecture (RSA) of Arabidopsis and how phosphate levels modulate responses of the root to salt stress. Phosphate (Pi) starvation reduced main root length and increased the number of lateral roots of Arabidopsis Col-0 seedlings. In combination with salt, low Pi dampened the inhibiting effect of mild salt stress (75mM) on all measured RSA components. At higher NaCl concentrations, the Pi deprivation response prevailed over the salt stress only for lateral root elongation. The Pi deprivation response of lateral roots appeared to be oppositely affected by abscisic acid (ABA) signaling compared to the salt stress response. Natural variation in the response to the combination treatment of salt and Pi starvation within 330 Arabidopsis accessions could be grouped into four response patterns. When exposed to double stress, in general lateral roots prioritized responses to salt, while the effect on main root traits was additive. Interestingly, these patterns were not identical for all accessions studied and multiple strategies to integrate the signals from Pi deprivation and salinity were identified. By Genome Wide Association Mapping (GWAS) 13 genomic loci were identified as putative factors integrating responses to salt stress and Pi starvation. From our experiments, we conclude that Pi starvation interferes with salt responses mainly at the level of lateral roots and that large natural variation exists in the available genetic repertoire of accessions to handle the combination of stresses.

  9. Phosphate-dependent root system architecture responses to salt stress

    KAUST Repository

    Kawa, Dorota

    2016-05-20

    Nutrient availability and salinity of the soil affect growth and development of plant roots. Here, we describe how phosphate availability affects root system architecture (RSA) of Arabidopsis and how phosphate levels modulate responses of the root to salt stress. Phosphate (Pi) starvation reduced main root length and increased the number of lateral roots of Arabidopsis Col-0 seedlings. In combination with salt, low Pi dampened the inhibiting effect of mild salt stress (75mM) on all measured RSA components. At higher NaCl concentrations, the Pi deprivation response prevailed over the salt stress only for lateral root elongation. The Pi deprivation response of lateral roots appeared to be oppositely affected by abscisic acid (ABA) signaling compared to the salt stress response. Natural variation in the response to the combination treatment of salt and Pi starvation within 330 Arabidopsis accessions could be grouped into four response patterns. When exposed to double stress, in general lateral roots prioritized responses to salt, while the effect on main root traits was additive. Interestingly, these patterns were not identical for all accessions studied and multiple strategies to integrate the signals from Pi deprivation and salinity were identified. By Genome Wide Association Mapping (GWAS) 13 genomic loci were identified as putative factors integrating responses to salt stress and Pi starvation. From our experiments, we conclude that Pi starvation interferes with salt responses mainly at the level of lateral roots and that large natural variation exists in the available genetic repertoire of accessions to handle the combination of stresses.

  10. Stressor sensor and stress management system

    NARCIS (Netherlands)

    2012-01-01

    A stressor detection system (100) comprises sensor means (101) arranged for being attached to a person for obtaining a time-varying signal representing a physical quantity relating to an environment of the person, and processing means (102) for deriving a stressor value from the obtained signal

  11. Stress

    Science.gov (United States)

    ... can be life-saving. But chronic stress can cause both physical and mental harm. There are at least three different types of stress: Routine stress related to the pressures of work, family, and other daily responsibilities Stress brought about ...

  12. STRESS AND DIFFERENTIAL ALTERATIONS IN IMMUNE-SYSTEM FUNCTIONS - CONCLUSIONS FROM SOCIAL STRESS STUDIES IN ANIMALS

    NARCIS (Netherlands)

    BOHUS, B; KOOLHAAS, JM; DERUITER, AJH; HEIJNEN, CJ

    1991-01-01

    Psychosocial factors are implicated in the development, in the course of, and in the recovery from disease. The immune system may be a mediator of the disease. Studies with animal models using social interactions in rodents suggest that short- and long-term social stress does not invariably suppress

  13. Systems responses to progressive water stress in durum wheat.

    Directory of Open Access Journals (Sweden)

    Dimah Z Habash

    Full Text Available Durum wheat is susceptible to terminal drought which can greatly decrease grain yield. Breeding to improve crop yield is hampered by inadequate knowledge of how the physiological and metabolic changes caused by drought are related to gene expression. To gain better insight into mechanisms defining resistance to water stress we studied the physiological and transcriptome responses of three durum breeding lines varying for yield stability under drought. Parents of a mapping population (Lahn x Cham1 and a recombinant inbred line (RIL2219 showed lowered flag leaf relative water content, water potential and photosynthesis when subjected to controlled water stress time transient experiments over a six-day period. RIL2219 lost less water and showed constitutively higher stomatal conductance, photosynthesis, transpiration, abscisic acid content and enhanced osmotic adjustment at equivalent leaf water compared to parents, thus defining a physiological strategy for high yield stability under water stress. Parallel analysis of the flag leaf transcriptome under stress uncovered global trends of early changes in regulatory pathways, reconfiguration of primary and secondary metabolism and lowered expression of transcripts in photosynthesis in all three lines. Differences in the number of genes, magnitude and profile of their expression response were also established amongst the lines with a high number belonging to regulatory pathways. In addition, we documented a large number of genes showing constitutive differences in leaf transcript expression between the genotypes at control non-stress conditions. Principal Coordinates Analysis uncovered a high level of structure in the transcriptome response to water stress in each wheat line suggesting genome-wide co-ordination of transcription. Utilising a systems-based approach of analysing the integrated wheat's response to water stress, in terms of biological robustness theory, the findings suggest that each durum

  14. A Hydraulic Stress Measurement System for Deep Borehole Investigations

    Science.gov (United States)

    Ask, Maria; Ask, Daniel; Cornet, Francois; Nilsson, Tommy

    2017-04-01

    Luleå University of Technology (LTU) is developing and building a wire-line system for hydraulic rock stress measurements, with funding from the Swedish Research Council and Luleå University of Technology. In this project, LTU is collaborating with University of Strasbourg and Geosigma AB. The stress state influences drilling and drillability, as well as rock mass stability and permeability. Therefore, knowledge about the state of in-situ stress (stress magnitudes, and orientations) and its spatial variation with depth is essential for many underground rock engineering projects, for example for underground storage of hazardous material (e.g. nuclear waste, carbon dioxide), deep geothermal exploration, and underground infrastructure (e.g. tunneling, hydropower dams). The system is designed to conduct hydraulic stress testing in slim boreholes. There are three types of test methods: (1) hydraulic fracturing, (2) sleeve fracturing and (3) hydraulic testing of pre-existing fractures. These are robust methods for determining in situ stresses from boreholes. Integration of the three methods allows determination of the three-dimensional stress tensor and its spatial variation with depth in a scientific unambiguously way. The stress system is composed of a downhole and a surface unit. The downhole unit consists of hydraulic fracturing equipment (straddle packers and downhole imaging tool) and their associated data acquisition systems. The testing system is state of the art in several aspects including: (1) Large depth range (3 km), (2) Ability to test three borehole dimensions (N=76 mm, H=96 mm, and P=122 mm), (3) Resistivity imager maps the orientation of tested fracture; (4) Highly stiff and resistive to corrosion downhole testing equipment; and (5) Very detailed control on the injection flow rate and cumulative volume is obtained by a hydraulic injection pump with variable piston rate, and a highly sensitive flow-meter. At EGU General Assembly 2017, we would like to

  15. Respiratory Effects and Systemic Stress Response Following ...

    Science.gov (United States)

    Previous studies have demonstrated that exposure to the pulmonary irritant ozone causes myriad systemic metabolic and pulmonary effects attributed to sympathetic and hypothalamus-pituitary-adrenal (HPA) axis activation, which are exacerbated in metabolically impaired models. We examined respiratory and systemic effects following exposure to a sensory irritant acrolein to elucidate the systemic and pulmonary consequences in healthy and diabetic rat models. Male Wistar and Goto Kakizaki (GK) rats, a nonobese type II diabetic Wistar-derived model, were exposed by inhalation to 0, 2, or 4 ppm acrolein, 4 h/d for 1 or 2 days. Exposure at 4 ppm significantly increased pulmonary and nasal inflammation in both strains with vascular protein leakage occurring only in the nose. Acrolein exposure (4 ppm) also caused metabolic impairment by inducing hyperglycemia and glucose intolerance (GK > Wistar). Serum total cholesterol (GKs only), low-density lipoprotein (LDL) cholesterol (both strains), and free fatty acids (GK > Wistar) levels increased; however, no acrolein-induced changes were noted in branched-chain amino acid or insulin levels. These responses corresponded with a significant increase in corticosterone and modest but insignificant increases in adrenaline in both strains, suggesting activation of the HPA axis. Collectively, these data demonstrate that acrolein exposure has a profound effect on nasal and pulmonary inflammation, as well as glucose and lipid metabolis

  16. Respiratory Effects and Systemic Stress Response Following ...

    Science.gov (United States)

    Previous studies have demonstrated that exposure to ozone, a pulmonary irritant, causes myriad systemic metabolic and pulmonary effects that are attributed to neuronal and hypothalamus-pituitary-adrenal (HPA) axis activation, which are exacerbated in metabolically-impaired models. In order to elucidate the systemic consequences and the contribution of the HPA axis in mediating metabolic and respiratory effects of acrolein, a sensory irritant, we examined pulmonary, nasal, and systemic effects in rats following exposure. Male, 10 week old Wistar and Goto Kakizaki (GK) rats, a non-obese type II diabetic Wistar-derived model, were exposed to 0, 2 or 4 ppm acrolein, 4h/day for 1 or 2 days. Acrolein exposure at 4 ppm significantly increased pulmonary and nasal damage in both strains as demonstrated by increased inspiratory and expiratory times indicating labored breathing, elevated biomarkers of injury, and neutrophilic inflammation. Overall, at both time points acrolein exposure caused noticeably more damage in the nasal passages as opposed to the lung with vascular protein leakage occurring only in the nose. Acrolein exposure (4 ppm) also led to metabolic impairment by inducing hyperglycemia and glucose intolerance (GK>Wistar) as indicated by glucose tolerance testing. In addition, serum total cholesterol (GKs only), LDL cholesterol (both strains), and free fatty acids (GK>Wistar) levels increased; however, no acrolein-induced changes were noted in branched-c

  17. Experimental investigation of system effects in stressed-skin elements

    DEFF Research Database (Denmark)

    Dela Stang, B.; Isaksson, T.; Hansson, M.

    What kind of behaviour can be expected from stressed-skin elements at failure? To answer this question was a primary objective of the experimental investigation presented in this report. Systems of 3 roof units, each made of 5 parallel beams, have been tested for load-carrying capacity and behavi......What kind of behaviour can be expected from stressed-skin elements at failure? To answer this question was a primary objective of the experimental investigation presented in this report. Systems of 3 roof units, each made of 5 parallel beams, have been tested for load-carrying capacity...

  18. Coulomb Stress Accumulation along the San Andreas Fault System

    Science.gov (United States)

    Smith, Bridget; Sandwell, David

    2003-01-01

    Stress accumulation rates along the primary segments of the San Andreas Fault system are computed using a three-dimensional (3-D) elastic half-space model with realistic fault geometry. The model is developed in the Fourier domain by solving for the response of an elastic half-space due to a point vector body force and analytically integrating the force from a locking depth to infinite depth. This approach is then applied to the San Andreas Fault system using published slip rates along 18 major fault strands of the fault zone. GPS-derived horizontal velocity measurements spanning the entire 1700 x 200 km region are then used to solve for apparent locking depth along each primary fault segment. This simple model fits remarkably well (2.43 mm/yr RMS misfit), although some discrepancies occur in the Eastern California Shear Zone. The model also predicts vertical uplift and subsidence rates that are in agreement with independent geologic and geodetic estimates. In addition, shear and normal stresses along the major fault strands are used to compute Coulomb stress accumulation rate. As a result, we find earthquake recurrence intervals along the San Andreas Fault system to be inversely proportional to Coulomb stress accumulation rate, in agreement with typical coseismic stress drops of 1 - 10 MPa. This 3-D deformation model can ultimately be extended to include both time-dependent forcing and viscoelastic response.

  19. Memory under stress: from single systems to network changes.

    Science.gov (United States)

    Schwabe, Lars

    2017-02-01

    Stressful events have profound effects on learning and memory. These effects are mainly mediated by catecholamines and glucocorticoid hormones released from the adrenals during stressful encounters. It has been known for long that both catecholamines and glucocorticoids influence the functioning of the hippocampus, a critical hub for episodic memory. However, areas implicated in other forms of memory, such as the insula or the dorsal striatum, can be affected by stress as well. Beyond changes in single memory systems, acute stress triggers the reconfiguration of large scale neural networks which sets the stage for a shift from thoughtful, 'cognitive' control of learning and memory toward more reflexive, 'habitual' processes. Stress-related alterations in amygdala connectivity with the hippocampus, dorsal striatum, and prefrontal cortex seem to play a key role in this shift. The bias toward systems proficient in threat processing and the implementation of well-established routines may facilitate coping with an acute stressor. Overreliance on these reflexive systems or the inability to shift flexibly between them, however, may represent a risk factor for psychopathology in the long-run. © 2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  20. Experimental stress analysis for determination of residual stresses and integrity monitoring of components and systems

    International Nuclear Information System (INIS)

    1993-01-01

    For an analysis of the safety-related significance of residual stresses, mechanical, magnetic as well as ultrasonic and diffraction methods can be applied as testing methods. The results of an interlaboratory test concerning the experimental determination of residual stresses in a railway track are included. Further, questions are analyzed concerning the in-service inspections of components and systems with regard to their operational safety and life. Measurement methods are explained by examples from power plant engineering, nuclear power plant engineering, construction and traffic engineering as well as aeronautics. (DG) [de

  1. Friction and bending forces evaluation of AISI 304 DDQ steel sheet forming by bending tests under deep-drawing multiaxial stresses; Evaluacion de la fuerza de doblado y de friccion en el conformado de chapa de acero inoxidable AISI 304 DDQ mediante ensayos de doblado en condiciones multiaxiales de embuticion

    Energy Technology Data Exchange (ETDEWEB)

    Coello, J.; Miguel, V.; Ferrer, C.; Calatayud, A.; Martinez, A.

    2012-11-01

    Die radius is a critical area from the viewpoint of friction in forming processes. Moreover the sheet, that has been previously deformed in flange area, suffers bending and unbending stresses. Then, die-sheet contact in die radius must be especially considered in order to guarantee the suitable lubrication conditions. In the present work, a test method is carried out for evaluating an AISI 304 DDQ steel under similar conditions to those existing in the die radius area and that, usually, are not really reproduced in traditional bending under tensions tests. Deformation under pure shear condition, the bending and the radius angle have been established as variables of the tests. Results allow to obtain the apparent pressure sheet-bending tool, that increases with bending angle and decreases with tool radius. This last variable is the most significant while the bending angle has lesser influence. Although experimental results present some concordances with values obtained by analytical methods, some corrections must be considered in them in order to improve the theoretical values. (Author) 18 refs.

  2. The Stress Management in the Enterprise Management System

    Directory of Open Access Journals (Sweden)

    Kuzmin Oleh Ye.

    2017-05-01

    Full Text Available The article systematizes the classification of the type of management by a number of attributes: horizon of ambition, priority style of interaction between management and managed systems, level of centralization, orientation, consideration of environmental impact, contents, type of activity, and response to deviation. Within terms of the attribute of response to deviations, place of the stress management is allocated near to the harmonic and the risk management. It has been substantiated that the stress management is the enterprise management system aimed at overcoming unwanted deviations that are significant, extreme, and have a significant negative impact on the operation of enterprise. In the structure of the stress management, the following integral components have been allocated and characterized: crisis, adaptive, reactive, fears, and anticipative.

  3. Impact of emerging clean vehicle system on water stress

    International Nuclear Information System (INIS)

    Cai, Hua; Hu, Xiaojun; Xu, Ming

    2013-01-01

    Graphical abstract: Display Omitted - Highlights: • Clean vehicles may increase US water consumption up to 2810 billion gallons/year. • Large-scale clean vehicle adoption could lead to severe regional water stress. • Fuel choice for clean vehicle is crucial in minimizing regional water stress. • Regional optimization illustrated the importance of regional consideration. - Abstract: While clean vehicles (i.e., vehicles powered by alternative fuels other than fossil fuels) offer great potential to reduce greenhouse gas emissions from gasoline-based vehicles, the associated impact on water resources has not yet been fully assessed. This research provides a systematic evaluation of the impact of a fully implemented clean vehicle system on national and state-level water demand and water stress. On the national level, based on existing policies, transitioning the current gasoline-based transportation into one with clean vehicles will increase national annual water consumption by 1950–2810 billion gallons of water, depending on the market penetration of electric vehicles. On the state level, variances of water efficiency in producing different fuels are significant. The fuel choice for clean vehicle development is especially crucial for minimizing water stress increase in states with already high water stress, high travel demands, and significant variations in water efficiency in producing different alternative fuels. Current development of clean vehicle infrastructure, however, has not reflected these state-level variations. This study takes an optimization approach to further evaluate impacts on state-level water stress from a fully implemented clean vehicle system and identified potential roles (fuel producer or consumer) states may play in real world clean vehicle development scenario. With an objective of minimizing overall water stress impact, our optimization model aims to provide an analytical framework to better assess impacts on state-level water

  4. Studies on Stress-Strain Relationships of Polymeric Materials Used in Space Applications

    Science.gov (United States)

    Jana, Sadhan C.; Freed, Alan

    2002-01-01

    A two-year research plan was undertaken in association with Polymers Branch, NASA Glenn Research Center, to carry out experimental and modeling work relating stress and strain behavior of polymeric materials, especially elastomers and vulcanized rubber. An experimental system based on MTS (Mechanical Testing and Simulation) A/T-4 test facility environment has been developed for a broader range of polymeric materials in addition to a design of laser compatible temperature control chamber for online measurements of various strains. Necessary material processing has been accomplished including rubber compounding and thermoplastic elastomer processing via injection molding. A broad suite of testing methodologies has been identified to reveal the complex non-linear mechanical behaviors of rubbery materials when subjected to complex modes of deformation. This suite of tests required the conceptualization, design and development of new specimen geometries, test fixtures, and test systems including development of a new laser based technique to measure large multi-axial deformations. Test data has been generated for some of these new fixtures and has revealed some complex coupling effects generated during multi-axial deformations. In addition, fundamental research has been conducted concerning the foundation principles of rubber thermodynamics and resulting theories of rubber elasticity. Studies have been completed on morphological properties of several thermoplastic elastomers. Finally, a series of steps have been identified to further advance the goals of NASA's ongoing effort.

  5. Dysregulated physiological stress systems and accelerated cellular aging

    NARCIS (Netherlands)

    Révész, D.; Verhoeven, J.; Milaneschi, Y.; de Geus, E.J.C.; Wolkowitz, O.M.; Penninx, B.W.J.H.

    2014-01-01

    Exposure to chronic stressors is associated with accelerated biological aging as indicated by reduced leukocyte telomere length (LTL). This impact could be because of chronic overactivation of the body's physiological stress systems. This study examined the associations between LTL and the immune

  6. Stress analysis program system for nuclear vessel: STANSAS

    International Nuclear Information System (INIS)

    Okamoto, Asao; Michikami, Shinsuke

    1979-01-01

    IHI has developed a computer system of stress analysis and evaluation for nuclear vessels: STANSAS (STress ANalysis System for Axi-symmetric Structure). The system consists of more than twenty independent programs divided into the following six parts. 1. Programs for opening design by code rule. 2. Calculation model generating programs. 3. Load defining programs. 4. Structural analysis programs. 5. Load data/calculation results plotting programs. 6. Stress evaluation programs. Each program is connected with its pre- or post-processor through three data-bases which enable automatic data transfer. The user can make his choice of structural analysis programs in accordance with the problem to be solved. The interface to STANSAS can be easily installed in generalized structural analysis programs such as NASTRAN and MARC. For almost all tables and figures in the stress report, STANSAS has the function to print or plot out. The complicated procedures of ''Design by Analysis'' for pressure vessels have been well standardized by STANSAS. The system will give a high degree of efficiency and confidence to the design work. (author)

  7. The stress systems in depression: a postmortem study

    Directory of Open Access Journals (Sweden)

    Ai-Min Bao

    2014-12-01

    Full Text Available After trauma, depressive disorders are among the most frequent emerging diagnoses. However, although the symptoms of depression are well characterized, the molecular mechanisms underlying this disorder are largely unknown. Factors involved in the heterogeneous pathogenesis of depression include polymorphisms in stress-related genes, gender, age, developmental history, and environmental (traumatic stressors such as epigenetic factors. These factors may make different parts of the stress-related brain systems more vulnerable to different stressful or traumatic life events or psychological stresses, causing alterations in a network of neurotransmitters and neuromodulators including amines, amino acids, nitric oxide (NO, and neuropeptides, and finally make individuals at risk for depression. The hypothalamo–pituitary–adrenal (HPA axis has a prominent position in this network. With the postmortem brain material obtained from the Netherlands Brain Bank, we have carried on a series of studies with the aim to elucidate the specific changes in these systems in relation to special subtypes of depression. Our final destination is to set up tailor-made treatment for depressive patients on the basis of his/her developmental history, genetic and epigenetic background, and the vulnerability in particular neurobiological systems. This presentation is a review of our findings of changes in systems of sex steroids, receptors in the hypothalamic paraventricular nucleus, corticotrophin-releasing hormone, orexin, γ-aminobutyric acid, and NO in the etiology of depression, in relation to HPA activity, sex differences, and suicide.

  8. Thermal stress analysis of the fuel storage facility

    International Nuclear Information System (INIS)

    Chen, W.W.

    1991-12-01

    This paper presents the results of a nonlinear finite-element analysis to determine the structural integrity of the walls of the nuclear fuel storage room in the Radio Isotope Power System Facility of the Fuels and Materials Examination Facility (FMEF) Project. The analysis was performed to assess the effects of thermal loading on the walls that would result from a loss-of-cooling accident. The results obtained from using the same three-dimensional finite-element model with different types of elements, the eight-node brick element and the nonlinear concrete element, and the calculated results using the analytical solutions, are compared. The concrete responses in terms of octahedral normal and shearing stresses are described. The crack and crush states of the concrete were determined on the basis of multiaxial failure criteria

  9. Theory Of Dewetting In A Filled Elastomer Under Stress

    Science.gov (United States)

    Peng, Steven T. J.

    1993-01-01

    Report presents theoretical study of dewetting between elastomeric binder and filler particles of highly filled elastomer under multiaxial tension and resulting dilatation of elastomer. Study directed toward understanding and predicting nonlinear stress-vs.-strain behavior of filled elastomeric rocket propellant, also applicable to rubber in highly loaded tire or in damping pad.

  10. The role of oxidative stress in nervous system aging.

    Science.gov (United States)

    Sims-Robinson, Catrina; Hur, Junguk; Hayes, John M; Dauch, Jacqueline R; Keller, Peter J; Brooks, Susan V; Feldman, Eva L

    2013-01-01

    While oxidative stress is implicated in aging, the impact of oxidative stress on aging in the peripheral nervous system is not well understood. To determine a potential mechanism for age-related deficits in the peripheral nervous system, we examined both functional and morphological changes and utilized microarray technology to compare normal aging in wild-type mice to effects in copper/zinc superoxide dismutase-deficient (Sod1(-/-)) mice, a mouse model of increased oxidative stress. Sod1(-/-) mice exhibit a peripheral neuropathy phenotype with normal sensory nerve function and deficits in motor nerve function. Our data indicate that a decrease in the synthesis of cholesterol, which is vital to myelin formation, correlates with the structural deficits in axons, myelin, and the cell body of motor neurons in the Sod1(+/+) mice at 30 months and the Sod1(-/-) mice at 20 months compared with mice at 2 months. Collectively, we have demonstrated that the functional and morphological changes within the peripheral nervous system in our model of increased oxidative stress are manifested earlier and resemble the deficits observed during normal aging.

  11. The Role of Oxidative Stress in Nervous System Aging

    Science.gov (United States)

    Sims-Robinson, Catrina; Hur, Junguk; Hayes, John M.; Dauch, Jacqueline R.; Keller, Peter J.; Brooks, Susan V.; Feldman, Eva L.

    2013-01-01

    While oxidative stress is implicated in aging, the impact of oxidative stress on aging in the peripheral nervous system is not well understood. To determine a potential mechanism for age-related deficits in the peripheral nervous system, we examined both functional and morphological changes and utilized microarray technology to compare normal aging in wild-type mice to effects in copper/zinc superoxide dismutase-deficient (Sod1−/−) mice, a mouse model of increased oxidative stress. Sod1−/− mice exhibit a peripheral neuropathy phenotype with normal sensory nerve function and deficits in motor nerve function. Our data indicate that a decrease in the synthesis of cholesterol, which is vital to myelin formation, correlates with the structural deficits in axons, myelin, and the cell body of motor neurons in the Sod1+/+ mice at 30 months and the Sod1−/− mice at 20 months compared with mice at 2 months. Collectively, we have demonstrated that the functional and morphological changes within the peripheral nervous system in our model of increased oxidative stress are manifested earlier and resemble the deficits observed during normal aging. PMID:23844146

  12. The role of oxidative stress in nervous system aging.

    Directory of Open Access Journals (Sweden)

    Catrina Sims-Robinson

    Full Text Available While oxidative stress is implicated in aging, the impact of oxidative stress on aging in the peripheral nervous system is not well understood. To determine a potential mechanism for age-related deficits in the peripheral nervous system, we examined both functional and morphological changes and utilized microarray technology to compare normal aging in wild-type mice to effects in copper/zinc superoxide dismutase-deficient (Sod1(-/- mice, a mouse model of increased oxidative stress. Sod1(-/- mice exhibit a peripheral neuropathy phenotype with normal sensory nerve function and deficits in motor nerve function. Our data indicate that a decrease in the synthesis of cholesterol, which is vital to myelin formation, correlates with the structural deficits in axons, myelin, and the cell body of motor neurons in the Sod1(+/+ mice at 30 months and the Sod1(-/- mice at 20 months compared with mice at 2 months. Collectively, we have demonstrated that the functional and morphological changes within the peripheral nervous system in our model of increased oxidative stress are manifested earlier and resemble the deficits observed during normal aging.

  13. Volumetric error modeling, identification and compensation based on screw theory for a large multi-axis propeller-measuring machine

    Science.gov (United States)

    Zhong, Xuemin; Liu, Hongqi; Mao, Xinyong; Li, Bin; He, Songping; Peng, Fangyu

    2018-05-01

    Large multi-axis propeller-measuring machines have two types of geometric error, position-independent geometric errors (PIGEs) and position-dependent geometric errors (PDGEs), which both have significant effects on the volumetric error of the measuring tool relative to the worktable. This paper focuses on modeling, identifying and compensating for the volumetric error of the measuring machine. A volumetric error model in the base coordinate system is established based on screw theory considering all the geometric errors. In order to fully identify all the geometric error parameters, a new method for systematic measurement and identification is proposed. All the PIGEs of adjacent axes and the six PDGEs of the linear axes are identified with a laser tracker using the proposed model. Finally, a volumetric error compensation strategy is presented and an inverse kinematic solution for compensation is proposed. The final measuring and compensation experiments have further verified the efficiency and effectiveness of the measuring and identification method, indicating that the method can be used in volumetric error compensation for large machine tools.

  14. Calcium efflux systems in stress signalling and adaptation in plants

    Directory of Open Access Journals (Sweden)

    Jayakumar eBose

    2011-12-01

    Full Text Available Transient cytosolic calcium ([Ca2+]cyt elevation is an ubiquitous denominator of the signalling network when plants are exposed to literally every known abiotic and biotic stress. These stress-induced [Ca2+]cyt elevations vary in magnitude, frequency and shape, depending on the severity of the stress as well the type of stress experienced. This creates a unique stress-specific calcium signature that is then decoded by signal transduction networks. While most published papers have been focused predominantly on the role of Ca2+ influx mechanisms in shaping [Ca2+]cyt signatures, restoration of the basal [Ca2+]cyt levels is impossible without both cytosolic Ca2+ buffering and efficient Ca2+ efflux mechanisms removing excess Ca2+ from cytosol, to reload Ca2+ stores and to terminate Ca2+ signalling. This is the topic of the current review. The molecular identity of two major types of Ca2+ efflux systems, Ca2+-ATPase pumps and Ca2+/H+ exchangers, is described, and their regulatory modes are analysed in detail. The spatial and temporal organisation of calcium signalling networks is described, and the importance of existence of intracellular calcium microdomains is discussed. Experimental evidence for the role of Ca2+ efflux systems in plant responses to a range of abiotic and biotic factors is summarised. Contribution of Ca2+-ATPase pumps and Ca2+/H+ exchangers in shaping [Ca2+]cyt signatures is then modelled by using a four-component model (plasma- and endo- membrane-based Ca2+-permeable channels and efflux systems taking into account the cytosolic Ca2+ buffering. It is concluded that physiologically relevant variations in the activity of Ca2+-ATPase pumps and Ca2+/H+ exchangers are sufficient to fully describe all the reported experimental evidence and determine the shape of [Ca2+]cyt signatures in response to environmental stimuli, emphasising the crucial role these active efflux systems play in plant adaptive responses to environment.

  15. Cyclic response and early damage evolution in multiaxial cyclic loading of 316L austenitic steel

    Czech Academy of Sciences Publication Activity Database

    Mazánová, Veronika; Škorík, Viktor; Kruml, Tomáš; Polák, Jaroslav

    2017-01-01

    Roč. 100, JUL (2017), s. 466-476 ISSN 0142-1123 R&D Projects: GA MŠk LM2015069; GA MŠk(CZ) LQ1601; GA ČR(CZ) GA13-23652S; GA ČR GA15-08826S Institutional support: RVO:68081723 Keywords : 316L steel * Crack initiation * Cyclic plasticity * Damage mechanism * Multiaxial straining Subject RIV: JL - Materials Fatigue, Friction Mechanics OBOR OECD: Audio engineering, reliability analysis Impact factor: 2.899, year: 2016

  16. A method for calculation of finite fatigue life under multiaxial loading in high-cycle domain

    Directory of Open Access Journals (Sweden)

    M. Malnati

    2014-04-01

    Full Text Available A method for fatigue life assessment in high-cycle domain under multiaxial loading is presented in this paper. This approach allows fatigue assessment under any kind of load history, without limitations. The methodology lies on the construction - at a macroscopic level - of an “indicator” in the form of a set of cycles, representing plasticity that can arise at mesoscopic level throughout fatigue process. During the advancement of the loading history new cycles are created and a continuous evaluation of the damage is made.

  17. Experimental creep behaviour determination of cladding tube materials under multi-axial loadings

    International Nuclear Information System (INIS)

    Grosjean, Catherine; Poquillon, Dominique; Salabura, Jean-Claude; Cloue, Jean-Marc

    2009-01-01

    Cladding tubes are structural parts of nuclear plants, submitted to complex thermomechanical loadings. Thus, it is necessary to know and predict their behaviour to preserve their integrity and to enhance their lifetime. Therefore, a new experimental device has been developed to control the load path under multi-axial load conditions. The apparatus is designed to determine the thermomechanical behaviour of zirconium alloys used for cladding tubes. First results are presented. Creep tests with different biaxial loadings were performed. Results are analysed in terms of thermal expansion and of creep strain. The anisotropy of the material is revealed and iso-creep strain curves are given.

  18. Chlorine stress mediates microbial surface attachment in drinking water systems.

    Science.gov (United States)

    Liu, Li; Le, Yang; Jin, Juliang; Zhou, Yuliang; Chen, Guowei

    2015-03-01

    Microbial attachment to drinking water pipe surfaces facilitates pathogen survival and deteriorates disinfection performance, directly threatening the safety of drinking water. Notwithstanding that the formation of biofilm has been studied for decades, the underlying mechanisms for the origins of microbial surface attachment in biofilm development in drinking water pipelines remain largely elusive. We combined experimental and mathematical methods to investigate the role of environmental stress-mediated cell motility on microbial surface attachment in chlorination-stressed drinking water distribution systems. Results show that at low levels of disinfectant (0.0-1.0 mg/L), the presence of chlorine promotes initiation of microbial surface attachment, while higher amounts of disinfectant (>1.0 mg/L) inhibit microbial attachment. The proposed mathematical model further demonstrates that chlorination stress (0.0-5.0 mg/L)-mediated microbial cell motility regulates the frequency of cell-wall collision and thereby controls initial microbial surface attachment. The results reveal that transport processes and decay patterns of chlorine in drinking water pipelines regulate microbial cell motility and, thus, control initial surface cell attachment. It provides a mechanistic understanding of microbial attachment shaped by environmental disinfection stress and leads to new insights into microbial safety protocols in water distribution systems.

  19. Microstructural and mechanical properties of AA1100 aluminum processed by multi-axial incremental forging and shearing

    Energy Technology Data Exchange (ETDEWEB)

    Montazeri-Pour, M. [School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, P.O. Box 11155-4563, Tehran (Iran, Islamic Republic of); Advanced Metalforming and Thermomechanical Processing Laboratory, School of Metallurgy and Materials Engineering, University of Tehran, Tehran (Iran, Islamic Republic of); Parsa, M.H., E-mail: mhparsa@ut.ac.ir [School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, P.O. Box 11155-4563, Tehran (Iran, Islamic Republic of); Center of Excellence for High Performance Materials, School of Metallurgy and Materials Engineering, University of Tehran, Tehran (Iran, Islamic Republic of); Advanced Metalforming and Thermomechanical Processing Laboratory, School of Metallurgy and Materials Engineering, University of Tehran, Tehran (Iran, Islamic Republic of); Jafarian, H.R. [School of Metallurgy and Materials Engineering, Iran University of Science and Technology (IUST), Narmak, Tehran (Iran, Islamic Republic of); Taieban, S. [School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, P.O. Box 11155-4563, Tehran (Iran, Islamic Republic of)

    2015-07-15

    Multi-axial incremental forging and shearing (MAIFS), as a new severe plastic deformation technique, was successfully applied up to eight passes on the workpieces of commercially pure Al (AA1100). The microstructure evolutions and mechanisms of the grain refinement in the billets deformed through various passes of process were studied using the electron backscatter diffraction (EBSD) analysis. Microhardness measurements and tensile tests were carried out to evaluate the mechanical properties and deformation behavior of the material after successive passes of the MAIFS process. Measured microhardness evolution indicated that while the distribution of hardness was non-uniform after odd-numbered passes up to four passes, but thereafter outstanding deformation homogeneity was achieved when the consecutive MAIFS passes were applied. Tensile tests indicated that yield stress and ultimate tensile strength increased rapidly during the primary pass of process but thereafter there was only a minor increase up to four passes. After that, a little drop could be observed in strength and then it reached to a saturated magnitude. Measured microhardness distribution values exhibited the same trend, viz. it increased through successive passes to a limiting value beyond which it showed a minor decline by disappearance of points having maximum hardness. Some coarsening was taken place and the dislocation walls between the boundaries were reduced significantly in going from four to six passes. It was suggested that the absorption of the dislocations into grain boundaries as an effective recovery process under large deformations and short-range migration of grain boundaries might be significant mechanisms responsible for the softening observed after four passes of process.

  20. Microstructural and mechanical properties of AA1100 aluminum processed by multi-axial incremental forging and shearing

    International Nuclear Information System (INIS)

    Montazeri-Pour, M.; Parsa, M.H.; Jafarian, H.R.; Taieban, S.

    2015-01-01

    Multi-axial incremental forging and shearing (MAIFS), as a new severe plastic deformation technique, was successfully applied up to eight passes on the workpieces of commercially pure Al (AA1100). The microstructure evolutions and mechanisms of the grain refinement in the billets deformed through various passes of process were studied using the electron backscatter diffraction (EBSD) analysis. Microhardness measurements and tensile tests were carried out to evaluate the mechanical properties and deformation behavior of the material after successive passes of the MAIFS process. Measured microhardness evolution indicated that while the distribution of hardness was non-uniform after odd-numbered passes up to four passes, but thereafter outstanding deformation homogeneity was achieved when the consecutive MAIFS passes were applied. Tensile tests indicated that yield stress and ultimate tensile strength increased rapidly during the primary pass of process but thereafter there was only a minor increase up to four passes. After that, a little drop could be observed in strength and then it reached to a saturated magnitude. Measured microhardness distribution values exhibited the same trend, viz. it increased through successive passes to a limiting value beyond which it showed a minor decline by disappearance of points having maximum hardness. Some coarsening was taken place and the dislocation walls between the boundaries were reduced significantly in going from four to six passes. It was suggested that the absorption of the dislocations into grain boundaries as an effective recovery process under large deformations and short-range migration of grain boundaries might be significant mechanisms responsible for the softening observed after four passes of process

  1. Fault tolerance improvement for queuing systems under stress load

    International Nuclear Information System (INIS)

    Nikonov, Eh.G.; Florko, A.B.

    2009-01-01

    Various kinds of queuing information systems (exchange auctions systems, web servers, SCADA) are faced to unpredictable situations during operation, when information flow that requires being analyzed and processed rises extremely. Such stress load situations often require human (dispatcher's or administrator's) intervention that is the reason why the time of the first denial of service is extremely important. Common queuing systems architecture is described. Existing approaches to computing resource management are considered. A new late-first-denial-of-service resource management approach is proposed

  2. Estimation of stress distribution in ferromagnetic tensile specimens using low cost eddy current stress measurement system and BP neural network.

    Directory of Open Access Journals (Sweden)

    Jianwei Li

    Full Text Available Estimation of the stress distribution in ferromagnetic components is very important for evaluating the working status of mechanical equipment and implementing preventive maintenance. Eddy current testing technology is a promising method in this field because of its advantages of safety, no need of coupling agent, etc. In order to reduce the cost of eddy current stress measurement system, and obtain the stress distribution in ferromagnetic materials without scanning, a low cost eddy current stress measurement system based on Archimedes spiral planar coil was established, and a method based on BP neural network to obtain the stress distribution using the stress of several discrete test points was proposed. To verify the performance of the developed test system and the validity of the proposed method, experiment was implemented using structural steel (Q235 specimens. Standard curves of sensors at each test point were achieved, the calibrated data were used to establish the BP neural network model for approximating the stress variation on the specimen surface, and the stress distribution curve of the specimen was obtained by interpolating with the established model. The results show that there is a good linear relationship between the change of signal modulus and the stress in most elastic range of the specimen, and the established system can detect the change in stress with a theoretical average sensitivity of -0.4228 mV/MPa. The obtained stress distribution curve is well consonant with the theoretical analysis result. At last, possible causes and improving methods of problems appeared in the results were discussed. This research has important significance for reducing the cost of eddy current stress measurement system, and advancing the engineering application of eddy current stress testing.

  3. Estimation of stress distribution in ferromagnetic tensile specimens using low cost eddy current stress measurement system and BP neural network.

    Science.gov (United States)

    Li, Jianwei; Zhang, Weimin; Zeng, Weiqin; Chen, Guolong; Qiu, Zhongchao; Cao, Xinyuan; Gao, Xuanyi

    2017-01-01

    Estimation of the stress distribution in ferromagnetic components is very important for evaluating the working status of mechanical equipment and implementing preventive maintenance. Eddy current testing technology is a promising method in this field because of its advantages of safety, no need of coupling agent, etc. In order to reduce the cost of eddy current stress measurement system, and obtain the stress distribution in ferromagnetic materials without scanning, a low cost eddy current stress measurement system based on Archimedes spiral planar coil was established, and a method based on BP neural network to obtain the stress distribution using the stress of several discrete test points was proposed. To verify the performance of the developed test system and the validity of the proposed method, experiment was implemented using structural steel (Q235) specimens. Standard curves of sensors at each test point were achieved, the calibrated data were used to establish the BP neural network model for approximating the stress variation on the specimen surface, and the stress distribution curve of the specimen was obtained by interpolating with the established model. The results show that there is a good linear relationship between the change of signal modulus and the stress in most elastic range of the specimen, and the established system can detect the change in stress with a theoretical average sensitivity of -0.4228 mV/MPa. The obtained stress distribution curve is well consonant with the theoretical analysis result. At last, possible causes and improving methods of problems appeared in the results were discussed. This research has important significance for reducing the cost of eddy current stress measurement system, and advancing the engineering application of eddy current stress testing.

  4. Competition between microstructure and defect in multiaxial high cycle fatigue

    Directory of Open Access Journals (Sweden)

    F. Morel

    2015-07-01

    Full Text Available This study aims at providing a better understanding of the effects of both microstructure and defect on the high cycle fatigue behavior of metallic alloys using finite element simulations of polycrystalline aggregates. It is well known that the microstructure strongly affects the average fatigue strength and when the cyclic stress level is close to the fatigue limit, it is often seen as the main source of the huge scatter generally observed in this fatigue regime. The presence of geometrical defects in a material can also strongly alter the fatigue behavior. Nonetheless, when the defect size is small enough, i.e. under a critical value, the fatigue strength is no more affected by the defect. The so-called Kitagawa effect can be interpreted as a competition between the crack initiation mechanisms governed either by the microstructure or by the defect. Surprisingly, only few studies have been done to date to explain the Kitagawa effect from the point of view of this competition, even though this effect has been extensively investigated in the literature. The primary focus of this paper is hence on the use of both FE simulations and explicit descriptions of the microstructure to get insight into how the competition between defect and microstructure operates in HCF. In order to account for the variability of the microstructure in the predictions of the macroscopic fatigue limits, several configurations of crystalline orientations, crystal aggregates and defects are studied. The results of each individual FE simulation are used to assess the response at the macroscopic scale thanks to a probabilistic fatigue criterion proposed by the authors in previous works. The ability of this criterion to predict the influence of defects on the average and the scatter of macroscopic fatigue limits is evaluated. In this paper, particular emphasis is also placed on the effect of different loading modes (pure tension, pure torsion and combined tension and torsion on

  5. Evaluation of stress corrosion crack growth in BWR piping systems

    International Nuclear Information System (INIS)

    Kassir, M.; Sharma, S.; Reich, M.; Chang, M.T.

    1985-05-01

    This report presents the results of a study conducted to evaluate the effects of stress intensity factor and environment on the growth behavior of intergranular stress corrosion cracks in type 304 stainless steel piping systems. Most of the detected cracks are known to be circumferential in shape, and initially started at the inside surface in the heat affected zone near girth welds. These cracks grow both radially in-depth and circumferentially in length and, in extreme cases, may cause leakage in the installation. The propagation of the crack is essentially due to the influence of the following simultaneous factors: (1) the action of applied and residual stress; (2) sensitization of the base metal in the heat affected zone adjacent to girth weld; and (3) the continuous exposure of the material to an aggressive environment of high temperature water containing dissolved oxygen and some levels of impurities. Each of these factors and their effects on the piping systems is discussed in detail in the report. The report also evaluates the time required for hypothetical cracks in BWR pipes to propagate to their critical size. The pertinent times are computed and displayed graphically. Finally, parametric study is performed in order to assess the relative influence and sensitivity of the various input parameters (residual stress, crack growth law, diameter of pipe, initial size of defect, etc.) which have bearing on the growth behavior of the intergranular stress corrosion cracks in type 304 stainless steel. Cracks in large-diameter as well as in small-diameter pipes are considered and analyzed. 27 refs., 25 figs., 10 tabs

  6. Heat stress monitoring system. Innovative technology summary report

    International Nuclear Information System (INIS)

    1998-11-01

    The US Department of Energy's (DOE) nuclear facility decontamination and decommissioning (D and D) program involves the need to decontaminate and decommission buildings expeditiously and cost-effectively. Simultaneously, the health and safety of personnel involved in the D and D activities is of primary concern. Often, D and D workers must perform duties in inclement weather, and because they also frequently work in contaminated areas, they must wear personal protective clothing and/or respirators. Monitoring the health status of workers under these conditions is an important component of ensuring their safety. The MiniMitter VitalSense Telemetry System's heat stress monitoring system (HSMS) is designed to monitor the vital signs of individual workers as they perform work in conditions that might be conducive to heat exhaustion or heat stress. The HSMS provides real-time data on the physiological condition of workers which can be monitored to prevent heat stress or other adverse health situations. This system is particularly useful when workers are wearing personal protective clothing or respirators that make visual observation of their condition more difficult. The MiniMitter VitalSense Telemetry System can monitor up to four channels (e.g., heart rate, body activity, ear canal, and skin temperature) and ten workers from a single supervisory station. The monitors are interfaced with a portable computer that updates and records information on individual workers. This innovative technology, even though it costs more, is an attractive alternative to the traditional (baseline) technology, which measures environmental statistics and predicts the average worker's reaction to those environmental conditions without taking the physical condition of the individual worker into consideration. Although use of the improved technology might be justified purely on the basis of improved safety, it has the potential to pay for itself by reducing worker time lost caused by heat

  7. Thermoelastic stress analysis system developed for industrial applications

    DEFF Research Database (Denmark)

    Haldorsen, Lars Magne

    The thesis is divided into three parts. The first part describes an extensive evaluation of the existing thermoelastic theory. The second part describes the development and results af a reliable numerical simulation code of the thermoelastic effect and the associated heat transfer effects. Finall......, theories, methods and additional equipment are developed in order to adopt a commercial IR-imaging system to preform Termoelastic Stress Analysis (TSA)....

  8. Energetical and multiscale approaches for the definition of an equivalent stress for magneto-elastic couplings

    International Nuclear Information System (INIS)

    Hubert, Olivier; Daniel, Laurent

    2011-01-01

    A main limitation of most models describing the effect of stress on the magnetic behavior is that they are restricted to uniaxial - tensile or compressive - stress. Nevertheless, stress is multiaxial in most of industrial applications. An idea to overcome the strong limitation of models is to define a fictive uniaxial stress, the equivalent stress, that would change the magnetic behavior in a similar manner than a multiaxial stress. A first definition of equivalent stress, called the deviatoric equivalent stress, is proposed. It is based on an equivalence in magneto-elastic energy. This formulation is first derived for isotropic materials under specific assumptions. An extension to orthotropic media under disoriented magneto-mechanical loading is made. A new equivalent stress expression, called generalized equivalent stress, is then proposed. It is based on an equivalence in magnetization. Inverse identification of equivalent stress is made possible thanks to a strong simplification of the description of the material seen as an assembly of elementary magnetic domains. It is shown that this second proposal is a generalization of the deviatoric expression. Equivalent stress proposals are compared to former proposals and validated using experimental results carried out on an iron-cobalt sheet submitted to biaxial mechanical loading. These results are compared to the predictions obtained thanks to the equivalent stress formulations. The generalized equivalent stress is shown to be a tool able to foresee the magnetic behavior of a large panel of materials submitted to multiaxial stress. - Research highlights: → Classical magneto-elastic models restricted to uniaxial stress. → Stress demonstrated multiaxial in most of industrial applications. → Proposals of deviatoric and generalized equivalent stresses - multidomain modeling. → Experimental validation using iron-cobalt sheet submitted to biaxial loading. → Generalization of former proposals and modeling of

  9. Time-dependent deformation of concrete under multiaxial stress conditions. Final report

    International Nuclear Information System (INIS)

    McDonald, J.E.

    1975-10-01

    An investigation was made on the time-dependent deformation behavior of concrete in the presence of temperature, moisture, and loading conditions similar to those encountered in a prestressed concrete reactor vessel (PCRV). This investigation encompassed one concrete strength (6000 psi at 28 days), three aggregate types (chert, limestone, and graywacke), one cement (Type II), two types of specimens (as-cast and air-dried), two levels of temperature during test (73 and 150 0 F), and four types of loading (uniaxial, hydrostatic, biaxial, and triaxial). This effort was intended primarily as a data report; the experimental procedures and results are presented in detail. A comprehensive evaluation of the effects of various parameters and their interactions on the behavior of concrete is not included. However, a number of general comparisons were made concerning the effect of the various test conditions on concrete behavior. Based on this limited evaluation of the data, general conclusions and recommendations for additional work were formulated

  10. Creep behavior of concrete under multiaxial stress at elevated temperature, 1

    International Nuclear Information System (INIS)

    Ohgishi, Sakichi; Kishitani, Koichi; Oshima, Hisaji; Kosaka, Yoshio; Shiire, Toyokazu.

    1977-01-01

    The field of application of concrete structures is extended to that of low and high temperature and dynamic loading. The creep of concrete has been studied under one, two or three axis compression below 80 deg. C, and this is owing to the design standards for PCPVs in Europe and America adopting the design temperature below 80 deg. C. However, the design temperature for PCPVs is expected to rise, and the high temperature, three axis creep of concrete must be studied to examine the physical property and thermodynamics in wide range of temperature, such as free energy gradient, the behavior of adsorbed water molecules, and activating energy, which control the creep. In this study, various problematical points in the development of a testing apparatus which can make three axis compression creep test from 300 to 500 deg. C were pointed out, and the measures to solve them were investigated. The creep testing apparatus was actually manufactured for trial, and the performance was tested. The design conditions for the testing apparatus, the problems in the manufacture, the selection of materials, and the results of trial are described. As for the pressurizing media, oil is used up to 180 deg. C, mercury up to 300 deg. C, and molten anatomical alloy in nitrogen atmosphere up to 500 deg. C. Buried Ailtech gauges can be used for the strain measurement up to 320 deg. C. The leakpreventing method for various penetrations was developed successfully. (Kako, I.)

  11. Telemetry System Utilization for Stress Monitoring of Pilots During Training

    Directory of Open Access Journals (Sweden)

    Luboš Socha

    2016-10-01

    Full Text Available Air transport development brings an increased focus on the safety of piloting. The safety conditions can be assessed by mental workload. Psychic discomfort or excessive stress on pilots can negatively influence the course of flights. Therefore it appears convenient to monitor such parameters, which represent the mental wellbeing, or discomfort of a pilot. Since physiological measurements can provide a good information about mental workload or stress, this work primarily focuses on the observation of the change in heart rate, as it is an indicator of stress during the training of pilots, using the designed modular telemetry system. Another aim of this study is to evaluate the influence of a change in the avionic data visualization. This can have an unfavorable effect on the piloting of an airplane. This work, based on the evaluation of heart rate shows, that the switch from analog visualization to glass cockpit creates increased levels of stress in pilots, which was proved for all examined subjects except one. Significant level of correlation in the heart beat rate change in subjects in the course of training was also discovered.

  12. Slicing algorithms for multi-axis 3-D metal printing of overhangs

    International Nuclear Information System (INIS)

    Lee, Kyu Bok; Jee, Hae Seong

    2015-01-01

    A group of 3D metal printing or Additive metal manufacturing (AMM) processes, officially categorized as 'directed energy deposition (DED)' according to American Society for Testing and Materials (ASTM) classification, has enabled the building of full dense metallic tools and parts using metal powders precisely delivered and controlled with no powder bed. Mold making and metalworking are being taken in an entirely new direction. The overhang/undercut problem in DED processes, as much as other Additive manufacturing (AM) processes, has long remained unsolved, and the ones equipped with more than 3-axis tool mechanism turn out to be capable of depositing overhang/undercut features onto the part to be made. Multi-axis machines introduced for resolving the problem, however, require advanced preprocess software support for the process management that controls multi-axis tool paths. This study proposes slicing algorithms, sophisticatedly designed for the control of the tool paths on a 5-axis base table, to build overhang/undercut features. A methodical approach, using an auto-partitioning algorithm for generating three-dimensional layer (3DL) information, is proposed in this study, and various overhang features, as case studies, have been investigated and implemented by using the proposed method.

  13. Slicing algorithms for multi-axis 3-D metal printing of overhangs

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyu Bok; Jee, Hae Seong [Hongik University, Seoul (Korea, Republic of)

    2015-11-15

    A group of 3D metal printing or Additive metal manufacturing (AMM) processes, officially categorized as 'directed energy deposition (DED)' according to American Society for Testing and Materials (ASTM) classification, has enabled the building of full dense metallic tools and parts using metal powders precisely delivered and controlled with no powder bed. Mold making and metalworking are being taken in an entirely new direction. The overhang/undercut problem in DED processes, as much as other Additive manufacturing (AM) processes, has long remained unsolved, and the ones equipped with more than 3-axis tool mechanism turn out to be capable of depositing overhang/undercut features onto the part to be made. Multi-axis machines introduced for resolving the problem, however, require advanced preprocess software support for the process management that controls multi-axis tool paths. This study proposes slicing algorithms, sophisticatedly designed for the control of the tool paths on a 5-axis base table, to build overhang/undercut features. A methodical approach, using an auto-partitioning algorithm for generating three-dimensional layer (3DL) information, is proposed in this study, and various overhang features, as case studies, have been investigated and implemented by using the proposed method.

  14. Structural and stress analysis of nuclear piping systems

    International Nuclear Information System (INIS)

    Hata, Hiromichi

    1982-01-01

    The design of the strength of piping system is important in plant design, and its outline on the example of PWRs is reported. The standards and guides concerning the design of the strength of piping system are shown. The design condition for the strength of piping system is determined by considering the requirements in the normal operation of plants and for the safety design of plants, and the loads in normal operation, testing, credible accident and natural environment are explained. The methods of analysis for piping system are related to the transient phenomena of fluid, piping structure and local heat conduction, and linear static analysis, linear time response analysis, nonlinear time response analysis, thermal stress analysis and fluid transient phenomenon analysis are carried out. In the aseismatic design of piping system, it is desirable to avoid the vibration together with a building supporting it, and as a rule, to make it into rigid structure. The piping system is classified into high temperature and low temperature pipings. The formulas for calculating stress and the allowable condition, the points to which attention must be paid in the design of piping strength and the matters to be investigated hereafter are described. (Kako, I.)

  15. System for stress corrosion conditions tests on PWR reactors

    International Nuclear Information System (INIS)

    Castro, Andre Cesar de Jesus

    2007-01-01

    The study of environmentally assisted cracking (EAC) involves the consideration and evaluation of the inherent compatibility between a material and the environment under conditions of either applied or residual stress. EAC is a critical problem because equipment, components and structure are subject to the influence of mechanical stress, water environment of different composition, temperature and different material history. Testing for resistance to EAC is one of the most effective ways to determine the interrelationships among this variables on the process of EAC. Up to now, several experimental techniques have been developed worldwide, which address different aspects of environmental caused damage. Constant loading of CT specimens test is a typical example of test, which is used for the estimation of parameters of stress corrosion cracking. To assess the initiation stages and kinetics of crack growth, the testing facility should allow active loading of specimens in the environment that is close to the actual operation conditions of assessed component. This paper presents a testing facility for stress corrosion cracking to be installed at CDTN, which was designed and developed at CDTN. The facility is used to carry out constant load tests under simulated PWR environment, where temperature, water pressure and chemistry are controlled, which are considered the most important factors in SCC. Also, the equipment operational conditions, its applications, and restrictions are presented. The system was developed to operate at temperature until 380 degree C and pressure until 180 bar. It consists in a autoclave stuck at a mechanical system, responsible of producing load , a water treatment station, and a data acquisition system. This testing facility allows the evaluation of cracking progress, especially at PWR reactor. (author) operational conditions. (author)

  16. A prognostic scoring system for arm exercise stress testing.

    Science.gov (United States)

    Xie, Yan; Xian, Hong; Chandiramani, Pooja; Bainter, Emily; Wan, Leping; Martin, Wade H

    2016-01-01

    Arm exercise stress testing may be an equivalent or better predictor of mortality outcome than pharmacological stress imaging for the ≥50% for patients unable to perform leg exercise. Thus, our objective was to develop an arm exercise ECG stress test scoring system, analogous to the Duke Treadmill Score, for predicting outcome in these individuals. In this retrospective observational cohort study, arm exercise ECG stress tests were performed in 443 consecutive veterans aged 64.1 (11.1) years. (mean (SD)) between 1997 and 2002. From multivariate Cox models, arm exercise scores were developed for prediction of 5-year and 12-year all-cause and cardiovascular mortality and 5-year cardiovascular mortality or myocardial infarction (MI). Arm exercise capacity in resting metabolic equivalents (METs), 1 min heart rate recovery (HRR) and ST segment depression ≥1 mm were the stress test variables independently associated with all-cause and cardiovascular mortality by step-wise Cox analysis (all pstatistic of 0.81 before and 0.88 after adjustment for significant demographic and clinical covariates. Arm exercise scores for the other outcome end points yielded C-statistic values of 0.77-0.79 before and 0.82-0.86 after adjustment for significant covariates versus 0.64-0.72 for best fit pharmacological myocardial perfusion imaging models in a cohort of 1730 veterans who were evaluated over the same time period. Arm exercise scores, analogous to the Duke Treadmill Score, have good power for prediction of mortality or MI in patients who cannot perform leg exercise.

  17. Computation of thermodynamic equilibrium in systems under stress

    Science.gov (United States)

    Vrijmoed, Johannes C.; Podladchikov, Yuri Y.

    2016-04-01

    Metamorphic reactions may be partly controlled by the local stress distribution as suggested by observations of phase assemblages around garnet inclusions related to an amphibolite shear zone in granulite of the Bergen Arcs in Norway. A particular example presented in fig. 14 of Mukai et al. [1] is discussed here. A garnet crystal embedded in a plagioclase matrix is replaced on the left side by a high pressure intergrowth of kyanite and quartz and on the right side by chlorite-amphibole. This texture apparently represents disequilibrium. In this case, the minerals adapt to the low pressure ambient conditions only where fluids were present. Alternatively, here we compute that this particular low pressure and high pressure assemblage around a stressed rigid inclusion such as garnet can coexist in equilibrium. To do the computations we developed the Thermolab software package. The core of the software package consists of Matlab functions that generate Gibbs energy of minerals and melts from the Holland and Powell database [2] and aqueous species from the SUPCRT92 database [3]. Most up to date solid solutions are included in a general formulation. The user provides a Matlab script to do the desired calculations using the core functions. Gibbs energy of all minerals, solutions and species are benchmarked versus THERMOCALC, PerpleX [4] and SUPCRT92 and are reproduced within round off computer error. Multi-component phase diagrams have been calculated using Gibbs minimization to benchmark with THERMOCALC and Perple_X. The Matlab script to compute equilibrium in a stressed system needs only two modifications of the standard phase diagram script. Firstly, Gibbs energy of phases considered in the calculation is generated for multiple values of thermodynamic pressure. Secondly, for the Gibbs minimization the proportion of the system at each particular thermodynamic pressure needs to be constrained. The user decides which part of the stress tensor is input as thermodynamic

  18. Neighborhood Stress and Autonomic Nervous System Activity during Sleep.

    Science.gov (United States)

    Mellman, Thomas Alan; Bell, Kimberly Ann; Abu-Bader, Soleman Hassan; Kobayashi, Ihori

    2018-04-04

    Stressful neighborhood environments are known to adversely impact health and contribute to health disparities but underlying mechanisms are not well understood. Healthy sleep can provide a respite from sustained sympathetic nervous system (SNS) activity. Our objective was to evaluate relationships between neighborhood stress and nocturnal and daytime SNS and parasympathetic nervous system (PNS) activity. Eighty five urban-residing African Americans (56.5% female; mean age of 23.0) participated. Evaluation included surveys of neighborhood stress and sleep-related vigilance; and continuous ECG and actigraphic recording in participants' homes from which heart rate variability (HRV) analysis for low frequency/high frequency (LF/HF) ratio and normalized high frequency (nHF), as indicators of SNS and PNS activity, respectively, and total sleep time (TST), and wake after sleep onset were derived. All significant relationships with HRV measures were from the sleep period. Neighborhood disorder correlated negatively with nHF (r = -.24, p = .035). There were also significant correlations of HRV indices with sleep duration and sleep fears. Among females, LF/HF correlated with exposure to violence, r = .39, p = .008 and nHF with census tract rates for violent crime (r = -.35, p = .035). In a stepwise regression, TST accounted for the variance contributed by violent crime to nHF in the female participants. Further investigation of relationships between neighborhood environments and SNS/PNS balance during sleep and their consequences, and strategies for mitigating such effects would have implications for health disparities.

  19. Stress

    Science.gov (United States)

    ... taking care of an aging parent. With mental stress, the body pumps out hormones to no avail. Neither fighting ... with type 1 diabetes. This difference makes sense. Stress blocks the body from releasing insulin in people with type 2 ...

  20. Dysregulated physiological stress systems and accelerated cellular aging.

    Science.gov (United States)

    Révész, Dóra; Verhoeven, Josine E; Milaneschi, Yuri; de Geus, Eco J C N; Wolkowitz, Owen M; Penninx, Brenda W J H

    2014-06-01

    Exposure to chronic stressors is associated with accelerated biological aging as indicated by reduced leukocyte telomere length (LTL). This impact could be because of chronic overactivation of the body's physiological stress systems. This study examined the associations between LTL and the immune system, hypothalamic-pituitary-adrenal axis and autonomic nervous system. LTL was assessed in 2936 adults from the Netherlands Study of Depression and Anxiety. Inflammation markers (interleukin-6, c-reactive protein, tumor necrosis factor-alpha), hypothalamic-pituitary-adrenal-axis indicators (salivary cortisol awakening curve [area under the curve indicators, with respect to the ground and increase], evening levels, 0.5 mg dexamethasone cortisol suppression ratio), and autonomic nervous system measures (heart rate, respiratory sinus arrhythmia, pre-ejection period) were determined. Linear regression analyses were performed and adjusted for sociodemographic, lifestyle and clinical factors. Shorter LTL was significantly associated with higher c-reactive protein, interleukin-6, area under the curve with respect to increase, and heart rate. A cumulative index score was calculated based on the number of highest tertiles of these 4 stress markers. LTL demonstrated a significant gradient within subjects ranging from having zero (5528 base pairs) to having 4 elevated stress markers (5371 base pairs, p for trend = 0.002), corresponding to a difference of 10 years of accelerated biological aging. Contrary to the expectations, shorter LTL was also associated with longer pre-ejection period, indicating lower sympathetic tone. This large-scale study showed that inflammation, high awakening cortisol response, and increased heart rate are associated with shorter LTL, especially when they are dysregulated cumulatively. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. Responses to reductive stress in the cardiovascular system.

    Science.gov (United States)

    Handy, Diane E; Loscalzo, Joseph

    2017-08-01

    There is a growing appreciation that reductive stress represents a disturbance in the redox state that is harmful to biological systems. On a cellular level, the presence of increased reducing equivalents and the lack of beneficial fluxes of reactive oxygen species can prevent growth factor-mediated signaling, promote mitochondrial dysfunction, increase apoptosis, and decrease cell survival. In this review, we highlight the importance of redox balance in maintaining cardiovascular homeostasis and consider the tenuous balance between oxidative and reductive stress. We explain the role of reductive stress in models of protein aggregation-induced cardiomyopathies, such as those caused by mutations in αB-crystallin. In addition, we discuss the role of NADPH oxidases in models of heart failure and ischemia-reperfusion to illustrate how oxidants may mediate the adaptive responses to injury. NADPH oxidase 4, a hydrogen peroxide generator, also has a major role in promoting vascular homeostasis through its regulation of vascular tone, angiogenic responses, and effects on atherogenesis. In contrast, the lack of antioxidant enzymes that reduce hydrogen peroxide, such as glutathione peroxidase 1, promotes vascular remodeling and is deleterious to endothelial function. Thus, we consider the role of oxidants as necessary signals to promote adaptive responses, such as the activation of Nrf2 and eNOS, and the stabilization of Hif1. In addition, we discuss the adaptive metabolic reprogramming in hypoxia that lead to a reductive state, and the subsequent cellular redistribution of reducing equivalents from NADH to other metabolites. Finally, we discuss the paradoxical ability of excess reducing equivalents to stimulate oxidative stress and promote injury. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Stress analysis of CVD diamond window for ECH system

    International Nuclear Information System (INIS)

    Takahashi, Koji

    2001-03-01

    The stress analysis of a chemical vapor deposition (CVD) diamond window for Electron Cyclotron Heating and Current Drive (ECH/ECCD) system of fusion reactors is described. It was found that the real size diamond window (φ aper =70mm, t=2.25mm) withstood 14.5 atm. (1.45 MPa). The calculation results of the diamond window by ABAQUS code agree well with the results of the pressure test. The design parameters of the torus diamond window for a vacuum and a safety barrier were also obtained. (author)

  3. New design deforming controlling system of the active stressed lap

    Science.gov (United States)

    Ying, Li; Wang, Daxing

    2008-07-01

    A 450mm diameter active stressed lap has been developed in NIAOT by 2003. We design a new lap in 2007. This paper puts on emphases on introducing the new deforming control system of the lap. Aiming at the control characteristic of the lap, a new kind of digital deforming controller is designed. The controller consists of 3 parts: computer signal disposing, motor driving and force sensor signal disposing. Intelligent numeral PID method is applied in the controller instead of traditional PID. In the end, the result of new deformation are given.

  4. Failure analysis of radioisotopic heat source capsules tested under multi-axial conditions

    International Nuclear Information System (INIS)

    Zielinski, R.E.; Stacy, E.; Burgan, C.E.

    In order to qualify small radioisotopic heat sources for a 25-yr design life, multi-axial mechanical tests were performed on the structural components of the heat source. The results of these tests indicated that failure predominantly occurred in the middle of the weld ramp-down zone. Examination of the failure zone by standard metallographic techniques failed to indicate the true cause of failure. A modified technique utilizing chemical etching, scanning electron microscopy, and energy dispersive x-ray analysis was employed and dramatically indicated the true cause of failure, impurity concentration in the ramp-down zone. As a result of the initial investigation, weld parameters for the heat sources were altered. Example welds made with a pulse arc technique did not have this impurity buildup in the ramp-down zone

  5. Multiaxial mechanical response and constitutive modeling of esophageal tissues: Impact on esophageal tissue engineering.

    Science.gov (United States)

    Sommer, Gerhard; Schriefl, Andreas; Zeindlinger, Georg; Katzensteiner, Andreas; Ainödhofer, Herwig; Saxena, Amulya; Holzapfel, Gerhard A

    2013-12-01

    Congenital defects of the esophagus are relatively frequent, with 1 out of 2500 babies suffering from such a defect. A new method of treatment by implanting tissue engineered esophagi into newborns is currently being developed and tested using ovine esophagi. For the reconstruction of the biological function of native tissues with engineered esophagi, their cellular structure as well as their mechanical properties must be considered. Since very limited mechanical and structural data for the esophagus are available, the aim of this study was to investigate the multiaxial mechanical behavior of the ovine esophagus and the underlying microstructure. Therefore, uniaxial tensile, biaxial tensile and extension-inflation tests on esophagi were performed. The underlying microstructure was examined in stained histological sections through standard optical microscopy techniques. Moreover, the uniaxial ultimate tensile strength and residual deformations of the tissue were determined. Both the mucosa-submucosa and the muscle layers showed nonlinear and anisotropic mechanical behavior during uniaxial, biaxial and inflation testing. Cyclical inflation of the intact esophageal tube caused marked softening of the passive esophagi in the circumferential direction. The rupture strength of the mucosa-submucosa layer was much higher than that of the muscle layer. Overall, the ovine esophagus showed a heterogeneous and anisotropic behavior with different mechanical properties for the individual layers. The intact and layer-specific multiaxial properties were characterized using a well-known three-dimensional microstructurally based strain-energy function. This novel and complete set of data serves the basis for a better understanding of tissue remodeling in diseased esophagi and can be used to perform computer simulations of surgical interventions or medical-device applications. Copyright © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  6. Effect of fibre arrangement on the multiaxial fatigue of fibrous composites: a micromechanical computational model

    Directory of Open Access Journals (Sweden)

    Roberto Brighenti

    2015-10-01

    Full Text Available Structural components made of fibre-reinforced materials are frequently used in engineering applications. Fibre-reinforced composites are multiphase materials, and complex mechanical phenomena take place at limit conditions but also during normal service situations, especially under fatigue loading, causing a progressive deterioration and damage. Under repeated loading, the degradation mainly occurs in the matrix material and at the fibre-matrix interface, and such a degradation has to be quantified for design structural assessment purposes. To this end, damage mechanics and fracture mechanics theories can be suitably applied to examine such a problem. Damage concepts can be applied to the matrix mechanical characteristics and, by adopting a 3-D mixed mode fracture description of the fibre-matrix detachment, fatigue fracture mechanics concepts can be used to determine the progressive fibre debonding responsible for the loss of load bearing capacity of the reinforcing phase. In the present paper, a micromechanical model is used to evaluate the unixial or multiaxial fatigue behaviour of structures with equi-oriented or randomly distributed fibres. The spatial fibre arrangement is taken into account through a statistical description of their orientation angles for which a Gaussian-like distribution is assumed, whereas the mechanical effect of the fibres on the composite is accounted for by a homogenization approach aimed at obtaining the macroscopic elastic constants of the material. The composite material behaves as an isotropic one for randomly distributed fibres, while it is transversally isotropic for unidirectional fibres. The fibre arrangement in the structural component influences the fatigue life with respect to the biaxiality ratio for multiaxial constant amplitude fatigue loading. One representative parametric example is discussed.

  7. Application du concept de maillon faible à un critère d'endurance multiaxial

    Science.gov (United States)

    Flacelière, L.; Morel, F.; Palin-Luc, T.

    2002-12-01

    En fatigue à grand nombre de cycle, il est aujourd'hui admis que la distribution des contraintes, ainsi que la taille des composants, sont responsables de variations de la limite de fatigue. Sous chargement uniaxial ou multiaxial, on peut montrer qu'une approche statistique dite du maillon le plus faible, combiné à un critère multiaxial d'endurance basé sur une analyse micro plastique, permet de prédire la limite de fatigue de plusieurs matériaux métalliques. Quatre types de chargement sont analysés (traction-compression, torsion, flexion rotative et flexion plane), puis comparées aux résultats expérimentaux, pour une fonte et deux aciers haute résistance. L'approche statistique proposée permet d'intégrer un certain nombre d'aspects: la dispersion des données pour tous types de chargement, l'effet de gradient et l'influence de la présence de défauts matériaux. Enfin, ce modèle rend également compte de la diminution de la limite de fatigue avec l'augmentation du volume contraint. Les prédictions des probabilités de rupture sont raisonnables bien que seules des limites de fatigue relatives à des probabilités de rupture de 50% soient utilisées pour l'identification des paramètres du modèle.

  8. Dysfunctional Neurotransmitter Systems in Fibromyalgia, Their Role in Central Stress Circuitry and Pharmacological Actions on These Systems

    Directory of Open Access Journals (Sweden)

    Susanne Becker

    2012-01-01

    Full Text Available Fibromyalgia is considered a stress-related disorder, and hypo- as well as hyperactive stress systems (sympathetic nervous system and hypothalamic-pituitary-adrenal axis have been found. Some observations raise doubts on the view that alterations in these stress systems are solely responsible for fibromyalgia symptoms. Cumulative evidence points at dysfunctional transmitter systems that may underlie the major symptoms of the condition. In addition, all transmitter systems found to be altered in fibromyalgia influence the body's stress systems. Since both transmitter and stress systems change during chronic stress, it is conceivable that both systems change in parallel, interact, and contribute to the phenotype of fibromyalgia. As we outline in this paper, subgroups of patients might exhibit varying degrees and types of transmitter dysfunction, explaining differences in symptomatoloy and contributing to the heterogeneity of fibromyalgia. The finding that not all fibromyalgia patients respond to the same medications, targeting dysfunctional transmitter systems, further supports this hypothesis.

  9. Understanding Water-Stress Responses in Soybean Using Hydroponics System-A Systems Biology Perspective.

    Science.gov (United States)

    Tripathi, Prateek; Rabara, Roel C; Shulaev, Vladimir; Shen, Qingxi J; Rushton, Paul J

    2015-01-01

    The deleterious changes in environmental conditions such as water stress bring physiological and biochemical changes in plants, which results in crop loss. Thus, combating water stress is important for crop improvement to manage the needs of growing population. Utilization of hydroponics system in growing plants is questionable to some researchers, as it does not represent an actual field condition. However, trying to address a complex problem like water stress we have to utilize a simpler growing condition like the hydroponics system wherein every input given to the plants can be controlled. With the advent of high-throughput technologies, it is still challenging to address all levels of the genetic machinery whether a gene, protein, metabolite, and promoter. Thus, using a system of reduced complexity like hydroponics can certainly direct us toward the right candidates, if not completely help us to resolve the issue.

  10. Study of failure criterion applicable to elastic-plastic finite element analyses of wall-thinned pipes subjected to multi-axial loading. Case for groove type flaw under combined internal pressure and bending loading

    International Nuclear Information System (INIS)

    Mori, Kosuke; Meshii, Toshiyuki

    2015-01-01

    In this paper, a failure criterion applicable to large-strain finite element analysis (FEA) results was studied to predict the limit bending load M_c of the groove shaped wall-thinned pipes, under combined internal pressure and bending load, that experienced cracking. In our previous studies, Meshii and Ito (2012) considered cracking of pipes with groove shaped flaw (small axial length δ_z in Fig. 1) was due to the plastic instability at the wall-thinned section and proposed the Domain Collapse Criterion (DCC). The DCC could predict M_c of cracking for small δ_z by comparing the von Mises stress σ_M_i_s_e_s with the true tensile strength σ_B. Because the discrepancy in prediction of the M_c in the case of cracking was within 15%, it was considered that the predictability was could be improved further. Thus, in this work, attempt was made to improve the accuracy of M_c prediction with a perspective that multi-axial stress state might affect this plastic instability at the wall-thinned section. As a result of examination of the various failure criteria based on multi-axial stress, it was confirmed that the limit bending load of the groove flawed pipe that experienced cracking in experiment (Hereafter, it was expressed 'flawed pipe that experienced cracking') could be predicted within 5% accuracy by applying Hill's plastic instability onset criterion (Hill, 1952) to the outer surface of the crack penetration section. The accuracy of the predicted limit bending load was improved from DCC's within 15% to within 5%. (author)

  11. Mechanical impedance of the sitting human body in single-axis compared to multi-axis whole-body vibration exposure.

    Science.gov (United States)

    Holmlund, P; Lundström, R

    2001-01-01

    The study was aimed to investigate the mechanical impedance of the sitting human body and to compare data obtained in laboratory single-axis investigations with multi-axis data from in vehicle measurements. The experiments were performed in a laboratory for single-axis measurements. The multi-axis exposure was generated with an eight-seat minibus where the rear seats had been replaced with a rigid one. The subjects in the multi-axis experiment all participated in the single-axis experiments. There are quite a few investigations in the literature describing the human response to single-axis exposure. The response from the human body can be expected to be affected by multi-axis input in a different way than from a single-axis exposure. The present knowledge of the effect of multiple axis exposure is very limited. The measurements were performed using a specially designed force and accelerometer plate. This plate was placed between the subject and the hard seat. Outcome shows a clear difference between mechanical impedance for multi-axis exposure compared to single-axis. This is especially clear in the x-direction where the difference is very large. The conclusion is that it seems unlikely that single-axis mechanical impedance data can be directly transferred to a multi-axis environment. This is due to the force cross-talk between different directions.

  12. Reconstructing a Network of Stress-Response Regulators via Dynamic System Modeling of Gene Regulation

    Directory of Open Access Journals (Sweden)

    Wei-Sheng Wu

    2008-01-01

    Full Text Available Unicellular organisms such as yeasts have evolved mechanisms to respond to environmental stresses by rapidly reorganizing the gene expression program. Although many stress-response genes in yeast have been discovered by DNA microarrays, the stress-response transcription factors (TFs that regulate these stress-response genes remain to be investigated. In this study, we use a dynamic system model of gene regulation to describe the mechanism of how TFs may control a gene’s expression. Then, based on the dynamic system model, we develop the Stress Regulator Identification Algorithm (SRIA to identify stress-response TFs for six kinds of stresses. We identified some general stress-response TFs that respond to various stresses and some specific stress-response TFs that respond to one specifi c stress. The biological significance of our findings is validated by the literature. We found that a small number of TFs is probably suffi cient to control a wide variety of expression patterns in yeast under different stresses. Two implications can be inferred from this observation. First, the response mechanisms to different stresses may have a bow-tie structure. Second, there may be regulatory cross-talks among different stress responses. In conclusion, this study proposes a network of stress-response regulators and the details of their actions.

  13. Chronic stress impacts the cardiovascular system: animal models and clinical outcomes.

    Science.gov (United States)

    Golbidi, Saeid; Frisbee, Jefferson C; Laher, Ismail

    2015-06-15

    Psychological stresses are associated with cardiovascular diseases to the extent that cardiovascular diseases are among the most important group of psychosomatic diseases. The longstanding association between stress and cardiovascular disease exists despite a large ambiguity about the underlying mechanisms. An array of possibilities have been proposed including overactivity of the autonomic nervous system and humoral changes, which then converge on endothelial dysfunction that initiates unwanted cardiovascular consequences. We review some of the features of the two most important stress-activated systems, i.e., the humoral and nervous systems, and focus on alterations in endothelial function that could ensue as a result of these changes. Cardiac and hematologic consequences of stress are also addressed briefly. It is likely that activation of the inflammatory cascade in association with oxidative imbalance represents key pathophysiological components of stress-induced cardiovascular changes. We also review some of the commonly used animal models of stress and discuss the cardiovascular outcomes reported in these models of stress. The unique ability of animals for adaptation under stressful conditions lessens the extrapolation of laboratory findings to conditions of human stress. An animal model of unpredictable chronic stress, which applies various stress modules in a random fashion, might be a useful solution to this predicament. The use of stress markers as indicators of stress intensity is also discussed in various models of animal stress and in clinical studies. Copyright © 2015 the American Physiological Society.

  14. Stress generation and hierarchical fracturing in reactive systems

    Science.gov (United States)

    Jamtveit, B.; Iyer, K.; Royne, A.; Malthe-Sorenssen, A.; Mathiesen, J.; Feder, J.

    2007-12-01

    Hierarchical fracture patterns are the result of a slowly driven fracturing process that successively divides the rocks into smaller domains. In quasi-2D systems, such fracture patterns are characterized by four sided domains, and T-junctions where new fractures stop at right angles to pre-existing fractures. We describe fracturing of mm to dm thick enstatite layers in a dunite matrix from the Leka ophiolite complex in Norway. The fracturing process is driven by expansion of the dunite matrix during serpentinization. The cumulative distributions of fracture lengths show a scaling behavior that lies between a log - normal and power law (fractal) distribution. This is consistent with a simple fragmentation model in which domains are divided according to a 'top hat' distribution of new fracture positions within unfractured domains. Reaction-assisted hierarchical fracturing is also likely to be responsible for other (3-D) structures commonly observed in serpentinized ultramafic rocks, including the mesh-textures observed in individual olivine grains, and the high abundance of rectangular domains at a wide range of scales. Spectacular examples of 3-D hierarchical fracture patterns also form during the weathering of basaltic intrusions (dolerites). Incipient chemical weathering of dolerites in the Karoo Basin in South Africa occurs around water- filled fractures, originally produced by thermal contraction or by externally imposed stresses. This chemical weathering causes local expansion of the rock matrix and generates elastic stresses. On a mm to cm scale, these stresses lead to mechanical layer-by-layer spalling, producing the characteristic spheroidal weathering patterns. However, our field observations and computer simulations demonstrate that in confined environments, the spalling process alone is unable to relieve the elastic stresses. In such cases, chemical weathering drives a much larger scale hierarchical fracturing process in which fresh dolerite undergoes a

  15. The stress response system of proteins: Implications for bioreactor scaleup

    Science.gov (United States)

    Goochee, Charles F.

    1988-01-01

    Animal cells face a variety of environmental stresses in large scale bioreactors, including periodic variations in shear stress and dissolved oxygen concentration. Diagnostic techniques were developed for identifying the particular sources of environmental stresses for animal cells in a given bioreactor configuration. The mechanisms by which cells cope with such stresses was examined. The individual concentrations and synthesis rates of hundreds of intracellular proteins are affected by the extracellular environment (medium composition, dissolved oxygen concentration, ph, and level of surface shear stress). Techniques are currently being developed for quantifying the synthesis rates and concentrations of the intracellular proteins which are most sensitive to environmental stress. Previous research has demonstrated that a particular set of stress response proteins are synthesized by mammalian cells in response to temperature fluctuations, dissolved oxygen deprivation, and glucose deprivation. Recently, it was demonstrated that exposure of human kidney cells to high shear stress results in expression of a completely distinct set of intracellular proteins.

  16. Thermal fatigue appears to be more damaging than uniaxial isothermal fatigue for the austentic stainless steels, and application of multiaxial fatigue criteria

    International Nuclear Information System (INIS)

    Fissolo, Antoine; Gourdin, Cedric; Vincent, Ludovic

    2009-01-01

    For nuclear reactor components, uniaxial isothermal fatigue curves are used to estimate the crack initiation under thermal fatigue. However, such approach would be not sufficient in some cases where cracking was observed. To investigate differences between uniaxial and thermal fatigue damage, tests have been carried out at CEA using the thermal fatigue devices SPLASH and FAT3D: a bi-dimensional (2-D) loading status is obtained in SPLASH, whereas a tri-dimensional (3-D) loading status is obtained in FAT3D. All the analysed tests clearly show that crack initiation in thermal fatigue is faster than in uniaxial isothermal fatigue conditions: for identical levels of strain, the number of cycles required to achieve crack initiation is significantly lower. The enhanced damaging effect probably results from a pure mechanical origin: a nearly perfect biaxial state corresponds to an increased hydrostatic stress. Consequently, multiaxial fatigue criteria must be applied. The Zamrik's strain criterion and the energy criterion proposed by Ecole Polytechnique provide the best estimations. In that framework, the proposed new method coupling both RCC-MR strain estimations and Zamrik's criterion appears to be more promising for the designer. (orig.)

  17. Thermal fatigue appears to be more damaging than uniaxial isothermal fatigue for the austentic stainless steels, and application of multiaxial fatigue criteria

    Energy Technology Data Exchange (ETDEWEB)

    Fissolo, Antoine; Gourdin, Cedric [DM2S/SEMT/LISN, Gif sur Yvette (France); Vincent, Ludovic [DMN/SRMA/LCD, Gif sur Yvette (France)

    2009-07-01

    For nuclear reactor components, uniaxial isothermal fatigue curves are used to estimate the crack initiation under thermal fatigue. However, such approach would be not sufficient in some cases where cracking was observed. To investigate differences between uniaxial and thermal fatigue damage, tests have been carried out at CEA using the thermal fatigue devices SPLASH and FAT3D: a bi-dimensional (2-D) loading status is obtained in SPLASH, whereas a tri-dimensional (3-D) loading status is obtained in FAT3D. All the analysed tests clearly show that crack initiation in thermal fatigue is faster than in uniaxial isothermal fatigue conditions: for identical levels of strain, the number of cycles required to achieve crack initiation is significantly lower. The enhanced damaging effect probably results from a pure mechanical origin: a nearly perfect biaxial state corresponds to an increased hydrostatic stress. Consequently, multiaxial fatigue criteria must be applied. The Zamrik's strain criterion and the energy criterion proposed by Ecole Polytechnique provide the best estimations. In that framework, the proposed new method coupling both RCC-MR strain estimations and Zamrik's criterion appears to be more promising for the designer. (orig.)

  18. Stress

    DEFF Research Database (Denmark)

    Keller, Hanne Dauer

    2015-01-01

    Kapitlet handler om stress som følelse, og det trækker primært på de få kvalitative undersøgelser, der er lavet af stressforløb.......Kapitlet handler om stress som følelse, og det trækker primært på de få kvalitative undersøgelser, der er lavet af stressforløb....

  19. Stress !!!

    OpenAIRE

    Fledderus, M.

    2012-01-01

    Twee op de vijf UT-studenten hebben last van ernstige studiestress, zo erg zelfs dat het ze in hun privéleven belemmert. Die cijfers komen overeen met het landelijk beeld van stress onder studenten. Samen met 14 andere universiteits- en hogeschoolbladen enquêteerde UT Nieuws bijna 5500 studenten. Opvallend is dat mannelijke studenten uit Twente zich veel minder druk lijken te maken over hun studie. Onder vrouwen ligt de stress juist erg hoog ten opzichte van het landelijk gemiddelde.

  20. Tank waste remediation system heat stress control program report, 1995

    International Nuclear Information System (INIS)

    Carls, D.R.

    1995-01-01

    Protecting employees from heat stress within tank farms during the summer months is challenging. Work constraints typically experienced in tank farms complicate the measures taken to protect employees from heat stress. TWRS-Industrial Hygiene (IH) has endeavored to control heat stress injuries by anticipating, recognizing, evaluating and controlling the factors which lead or contribute to heat stress in Tank Farms. The TWRS Heat Stress Control Program covers such areas as: employee and PIC training, communication of daily heat stress alerts to tank farm personnel, setting work/rest regimens, and the use of engineering and personal protective controls when applicable. The program has increased worker awareness of heat stress and prevention, established provisions for worker rest periods, increased drinking water availability to help ensure worker hydration, and allowed for the increased use of other protective controls to combat heat stress. The TWRS Heat Stress Control Program is the cornerstone for controlling heat stress among tank farm employees. The program has made great strides since it's inception during the summer of 1994. Some improvements can still be made to enhance the program for the summer of 1996, such as: (1) procurement and use of personal heat stress monitoring equipment to ensure appropriate application of administrative controls, (2) decrease the need for use of containment tents and anti-contamination clothing, and (3) providing a wider variety of engineering and personal protective controls for heat stress prevention

  1. Facile Fabrication of Electrically Conductive Low-Density Polyethylene/Carbon Fiber Tubes for Novel Smart Materials via Multiaxial Orientation.

    Science.gov (United States)

    Li, Yijun; Nie, Min; Wang, Qi

    2018-01-10

    Electromechanical sensors are indispensable components in functional devices and robotics application. However, the fabrication of the sensors still maintains a challenging issue that high percolation threshold and easy failure of conductive network are derived from uniaxial orientation of conductive fillers in practical melt processing. Herein, we reported a facile fabrication method to prepare a multiaxial low-density polyethylene (LDPE)/carbon fibers (CFs) tube with bidirectional controllable electrical conductivity and sensitive strain-responsive performance via rotation extrusion technology. The multidimensional helical flow is confirmed in the reverse rotation extrusion, and the CFs readily respond to the flow field leading to a multiaxial orientation in the LDPE matrix. In contrast to uniaxial LDPE/CF composites, which perform a "head to head" conjunction, multiaxial-orientated CF networks exhibit a unique multilayer structure in which the CFs with distinct orientation direction intersect in the interface, endowing the LDPE/CF composites with a low percolation threshold (15 wt %) to those of the uniaxial ones (∼35 wt %). The angles between two axes play a vital role in determining the density of the conductive networks in the interface, which is predominant in tuning the bending-responsive behaviors with a gauge factor range from 12.5 to 56.3 and the corresponding linear respond region from ∼15 to ∼1%. Such a superior performance of conductive LDPE/CF tube confirms that the design of multiaxial orientation paves a novel way to facile fabrication of advanced cost-effective CF-based smart materials, shedding light on promising applications such as smart materials and intelligent engineering monitoring.

  2. Surrogate fuel assembly multi-axis shaker tests to simulate normal conditions of rail and truck transport

    Energy Technology Data Exchange (ETDEWEB)

    McConnell, Paul E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Koenig, Greg John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Uncapher, William Leonard [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Grey, Carissa [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Engelhardt, Charles [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Saltzstein, Sylvia J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sorenson, Ken B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-05-01

    This report describes the third set of tests (the “DCLa shaker tests”) of an instrumented surrogate PWR fuel assembly. The purpose of this set of tests was to measure strains and accelerations on Zircaloy-4 fuel rods when the PWR assembly was subjected to rail and truck loadings simulating normal conditions of transport when affixed to a multi-axis shaker. This is the first set of tests of the assembly simulating rail normal conditions of transport.

  3. Surrogate fuel assembly multi-axis shaker tests to simulate normal conditions of rail and truck transport

    Energy Technology Data Exchange (ETDEWEB)

    McConnell, Paul E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Koenig, Greg John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Uncapher, William Leonard [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Grey, Carissa [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Engelhardt, Charles [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Saltzstein, Sylvia J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sorenson, Ken B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-05-12

    This report describes the third set of tests (the “DCLa shaker tests”) of an instrumented surrogate PWR fuel assembly. The purpose of this set of tests was to measure strains and accelerations on Zircaloy-4 fuel rods when the PWR assembly was subjected to rail and truck loadings simulating normal conditions of transport when affixed to a multi-axis shaker. This is the first set of tests of the assembly simulating rail normal conditions of transport.

  4. On computing stress in polymer systems involving multi-body potentials from molecular dynamics simulation

    Science.gov (United States)

    Fu, Yao; Song, Jeong-Hoon

    2014-08-01

    Hardy stress definition has been restricted to pair potentials and embedded-atom method potentials due to the basic assumptions in the derivation of a symmetric microscopic stress tensor. Force decomposition required in the Hardy stress expression becomes obscure for multi-body potentials. In this work, we demonstrate the invariance of the Hardy stress expression for a polymer system modeled with multi-body interatomic potentials including up to four atoms interaction, by applying central force decomposition of the atomic force. The balance of momentum has been demonstrated to be valid theoretically and tested under various numerical simulation conditions. The validity of momentum conservation justifies the extension of Hardy stress expression to multi-body potential systems. Computed Hardy stress has been observed to converge to the virial stress of the system with increasing spatial averaging volume. This work provides a feasible and reliable linkage between the atomistic and continuum scales for multi-body potential systems.

  5. Fatigue life determination by damage measuring in SAE 8620 specimens steel subjected to multiaxial experiments in neutral and corrosive environment

    International Nuclear Information System (INIS)

    Silva, Luiz L. da; Filho, Nelson do N.A.; Gomes, Paulo de T.V.; Rabello, Emerson G.; Mansur, Tanius R.

    2013-01-01

    Fatigue is the fail phenomenon of a material subjected to cyclic loads. This phenomenon affects any component under loads (forces, temperatures, etc.) that changes in time. When there is a combined load, originating multiaxial fatigue, which is the most of the real loads, worst is the situation. Before the component fail, the fatigue phenomenon produces damages to its material and this is a cumulative process that could not be reduced. In the continuum mechanic context, material damage is defined as a parameter that reduces the component resistance and this could cause its fail. The process of damage measuring by changes in electrical resistance is used in this work, and from experimental results of SAE 8620 steel specimens subjected to multiaxial fatigue in corrosive and neutral environment, the remaining specimen time life could be determined. Each specimen has its initial electrical resistance measured and after a certain number of fatigue cycles stopping points, its electrical resistance was measured again. In order to study multiaxial fatigue in specimens, a machine that induces simultaneously bending and torsional loads in the specimen was developed. Air at the temperature range of 18 deg C and 20 deg C was considered neutral environment. The corrosive environment was a NaCl solution with a concentration of 3,5% in weigh. The experimental results showed that the measuring fatigue damage using the changes in electrical resistance is efficient and that is possible to estimate the effect of a corrosive environment in the fatigue damage. (author)

  6. Acute stress-induced cortisol elevations mediate reward system activity during subconscious processing of sexual stimuli

    NARCIS (Netherlands)

    Oei, N.Y.L.; Both, S.; van Heemst, D.; van der Grond, J.

    2014-01-01

    Stress is thought to alter motivational processes by increasing dopamine (DA) secretion in the brain's "reward system", and its key region, the nucleus accumbens (NAcc). However, stress studies using functional magnetic resonance imaging (fMRI), mainly found evidence for stress-induced decreases in

  7. Thermo-mechanical fatigue behaviour of the near-{gamma}-titanium aluminide alloy TNB-V5 under uniaxial and multiaxial loading

    Energy Technology Data Exchange (ETDEWEB)

    Brookes, Stephen Peter

    2009-12-19

    With increasing environmental awareness and the general need to economise on the use of fossil fuels, there is growing pressure for industry to produce lighter, more efficient, gas turbine engines. One such material that will help to achieve these improvements is the intermetallic gamma titanium aluminide ({gamma}-TiAl) alloy. At only half the density of current nickel-based superalloys its weight saving capability is highly desirable, however, its mechanical properties have not yet been fully explored especially, when it is to be considered for structural components in aeronautical gas turbine engines. Critical components in these engines typically experience large variations in temperatures and multiaxial states of stress under non-isothermal conditions. These stress states are known as tri-axial thermo-mechanical fatigue (TMF). The work presented here investigates the effects these multi-axial stresses, have on a {gamma}-TiAl, (Ti-45Al-5Nb-0.2B-0.2C) alloy under TMF conditions. The uniaxial, torsional and axialtorsional TMF behaviour of this {gamma}-TiAl alloy have been examined at 400 - 800 C with strain amplitudes ranging from 0.15% to 0.7%. The tests were conducted at both thermomechanical in-phase (IP) and out-of-phase (OP). Selected tests additionally contained a 180 seconds hold period. Fatigue lifetimes are strongly influenced by the strain amplitude, a small increase in amplitude reduces the lifetime considerably. The uniaxial IP tests showed significantly longer fatigue lifetimes than of all the tests performed. Torsional loading although have shorter fatigue lifetimes than the uniaxial IP loading they have longer fatigue lifetimes than the uniaxial OP loading. The non-proportional axial-torsional 90 degree OP test is most damaging which resulted in a shorter lifetime than the uniaxial OP test with the same Mises equivalent mechanical strain amplitude. A hold period at maximum temperatures reduced the lifetime for all tests regardless of the temperature

  8. Oxidative stress and fatigue in systemic lupus erythematosus.

    Science.gov (United States)

    Segal, B M; Thomas, W; Zhu, X; Diebes, A; McElvain, G; Baechler, E; Gross, M

    2012-08-01

    The objective of this study is to investigate the relationship of oxidative stress to fatigue in systemic lupus erythematosus (SLE). Patients with a confirmed diagnosis of SLE by ACR criteria and healthy controls completed validated questionnaires to assess depression and fatigue. Fatigue was measured with the Fatigue Severity Scale (FSS) and the Profile of Fatigue (Prof-F). Visual analogue scales (VAS) were also used to assess fatigue and pain. Depression was measured with the Center for Epidemiologic Studies Depression Scale (CES-D). Plasma F(2)-isoprostane was measured with gas chromatography/mass spectroscopy to assess oxidative stress. Evaluation included medical record review, physical exam and calculation of body mass index (BMI), disease activity (SLEDAI) and damage (SLICC) in the SLE patients. Seventy-one SLE patients with low disease activity (mean SLEDAI = 1.62 standard error (SE) 0.37, range 0-8) were compared to 51 controls. Fatigue-limiting physical activity (defined as FSS ≥ 4) was present in 56% of patients and 12% of controls. F(2)-isoprostane was higher in SLE patients with fatigue compared to not-fatigued SLE subjects (p = .0076) who were otherwise similar in ethnicity, disease activity and cardiovascular risk factors. Plasma F(2)-isoprostane was strongly correlated with FSS and Profile of Somatic Fatigue (Prof-S) (p fatigue (p = .005), CES-D (p = .008) and with BMI (p = .0001.) In a multivariate model, F(2)-isoprostane was a significant predictor of FSS after adjustment for age, BMI, pain and depression (p = .0002). Fatigue in SLE patients with low disease activity is associated with increased F(2)-isoprostane. F2-isoprostane could provide a useful biomarker to explore mitochondrial function and the regulation of oxidative pathways in patients with SLE in whom fatigue is a debilitating symptom.

  9. Knowledge-based Adaptive Tracking Control of Electro-hydraulic Actuator Systems

    DEFF Research Database (Denmark)

    Hansen, Poul Erik

    1997-01-01

    The paper deal with intelligent motion control and electro-hydraulic actuator systems for multiaxis machynes and robots.The research results are from the IMCIA research Programme supported by the Danish Technical Research Council, STVF.......The paper deal with intelligent motion control and electro-hydraulic actuator systems for multiaxis machynes and robots.The research results are from the IMCIA research Programme supported by the Danish Technical Research Council, STVF....

  10. From scientific instrument to industrial machine : Coping with architectural stress in embedded systems

    NARCIS (Netherlands)

    Doornbos, R.; Loo, S. van

    2012-01-01

    Architectural stress is the inability of a system design to respond to new market demands. It is an important yet often concealed issue in high tech systems. In From scientific instrument to industrial machine, we look at the phenomenon of architectural stress in embedded systems in the context of a

  11. Influence of chemical peeling on the skin stress response system.

    Science.gov (United States)

    Kimura, Ayako; Kanazawa, Nobuo; Li, Hong-Jin; Yonei, Nozomi; Yamamoto, Yuki; Furukawa, Fukumi

    2012-07-01

    Skin stress response system (SSRS) involves corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC)-derived peptides, such as adrenocorticotropic hormone (ACTH), a-melanocyte-stimulating hormone (MSH) and b-endorphin that are locally generated in response to locally provided stressors or proinflammatory cytokines. This system would restrict tissue damage and restore local homoeostasis. Trichloroacetic acid (TCA) is one of the most widely used peeling agents and applied for cosmetic treatment of photodamaged skin. However, the biological mechanism responsible for TCA peeling has yet to be fully determined. While our investigation focused on the inflammation and wound healing pathways, in the recent study, we have examined involvement of the SSRS as the third pathway. Mostly depending on our findings that TCA peeling activates the SSRS by inducing the POMC expression of keratinocytes in the CRH-independent manner, together with the results reported by other researchers, we can say that the biological effect of POMC seems to be responsible for the TCA-induced epidermal SSRS activation. © 2012 John Wiley & Sons A/S.

  12. Increased multiaxial lumbar motion responses during multiple-impulse mechanical force manually assisted spinal manipulation

    Directory of Open Access Journals (Sweden)

    Gunzburg Robert

    2006-04-01

    Full Text Available Abstract Background Spinal manipulation has been found to create demonstrable segmental and intersegmental spinal motions thought to be biomechanically related to its mechanisms. In the case of impulsive-type instrument device comparisons, significant differences in the force-time characteristics and concomitant motion responses of spinal manipulative instruments have been reported, but studies investigating the response to multiple thrusts (multiple impulse trains have not been conducted. The purpose of this study was to determine multi-axial segmental and intersegmental motion responses of ovine lumbar vertebrae to single impulse and multiple impulse spinal manipulative thrusts (SMTs. Methods Fifteen adolescent Merino sheep were examined. Tri-axial accelerometers were attached to intraosseous pins rigidly fixed to the L1 and L2 lumbar spinous processes under fluoroscopic guidance while the animals were anesthetized. A hand-held electromechanical chiropractic adjusting instrument (Impulse was used to apply single and repeated force impulses (13 total over a 2.5 second time interval at three different force settings (low, medium, and high along the posteroanterior axis of the T12 spinous process. Axial (AX, posteroanterior (PA, and medial-lateral (ML acceleration responses in adjacent segments (L1, L2 were recorded at a rate of 5000 samples per second. Peak-peak segmental accelerations (L1, L2 and intersegmental acceleration transfer (L1–L2 for each axis and each force setting were computed from the acceleration-time recordings. The initial acceleration response for a single thrust and the maximum acceleration response observed during the 12 multiple impulse trains were compared using a paired observations t-test (POTT, alpha = .05. Results Segmental and intersegmental acceleration responses mirrored the peak force magnitude produced by the Impulse Adjusting Instrument. Accelerations were greatest for AX and PA measurement axes. Compared to

  13. Predator-scent stress, ethanol consumption and the opioid system in an animal model of PTSD.

    Science.gov (United States)

    Manjoch, Hadar; Vainer, Ella; Matar, Michael; Ifergane, Gal; Zohar, Joseph; Kaplan, Zeev; Cohen, Hagit

    2016-06-01

    Emerging literature points to stress exposure as a potential contributor to the development of alcohol abuse, but animal models have yielded inconsistent results. Converging experimental data indicate that the endogenous opioid system modulates alcohol consumption and stress regulation. The aim of the present study is to examine the interplay between stress exposure, behavioral stress responses, ethanol (EtOH) consumption and the endogenous opioid system in an animal model of posttraumatic stress disorder. Rats were exposed to stress and then tested in a two-bottle free choice (TBC) assay or in a conditioned place preference paradigm. In some experiments, the endogenous opioid system was pharmacologically manipulated prior to stress exposure. The behavioral outcomes of stress exposure were assessed in an elevated plus-maze, with the acoustic startle response, and by monitoring the freezing response to trauma reminder. Immunoreactivity of phosphorylated opioid receptors in hippocampal subregions was also measured. Stress significantly increased the consumption of EtOH in the TBC assay. The severity of the behavioral response to stress was associated with EtOH consumption, cue-triggered freezing response to a trauma reminder, and endogenous levels of phosphorylated opioid receptors in the hippocampus. Pharmacologically manipulating the endogenous opioid system prior to stress exposure attenuated trauma cue-triggered freezing responses and blocked predator scent stress-induced potentiation of EtOH consumption. These data demonstrate a stress-induced potentiation of EtOH self-administration and reveal a clear association between individual patterns of the behavioral response to stress and alcohol preference, while indicating a role for the endogenous opioid system in the neurobiological response to stress. Copyright © 2016. Published by Elsevier B.V.

  14. Systems Biology Approach to Understanding Post-traumatic Stress Disorder

    Science.gov (United States)

    2015-01-14

    Post - traumatic stress disorder ( PTSD ) is a psychological disorder a???ecting individuals that have experienced life-changing... post - traumatic stress disorder 5a. CONTRACT NUMBER W911NF-10-2-0111 & USAMRMC 09284002 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...challenges As stated in the Introduction, post - traumatic stress disorder is the only psychological disorder for which the onset of the

  15. Stress !!!

    NARCIS (Netherlands)

    Fledderus, M.

    2012-01-01

    Twee op de vijf UT-studenten hebben last van ernstige studiestress, zo erg zelfs dat het ze in hun privéleven belemmert. Die cijfers komen overeen met het landelijk beeld van stress onder studenten. Samen met 14 andere universiteits- en hogeschoolbladen enquêteerde UT Nieuws bijna 5500 studenten.

  16. Multi-modal sensor system for plant water stress assessment

    Science.gov (United States)

    Plant stress critically affects plant growth and causes significant loss of productivity and quality. When the plant is under water stress, it impedes photosynthesis and transpiration, resulting in changes in leaf color and temperature. Leaf discoloration in photosynthesis can be assessed by measu...

  17. Stress analysis of piping systems and piping supports. Documentation

    International Nuclear Information System (INIS)

    Rusitschka, Erwin

    1999-01-01

    The presentation is focused on the Computer Aided Tools and Methods used by Siemens/KWU in the engineering activities for Nuclear Power Plant Design and Service. In the multi-disciplinary environment, KWU has developed specific tools to support As-Built Documentation as well as Service Activities. A special application based on Close Range Photogrammetry (PHOCAS) has been developed to support revamp planning even in a high level radiation environment. It comprises three completely inter-compatible expansion modules - Photo Catalog, Photo Database and 3D-Model - to generate objects which offer progressively more utilization and analysis options. To support the outage planning of NPP/CAD-based tools have been developed. The presentation gives also an overview of the broad range of skills and references in: Plant Layout and Design using 3D-CAD-Tools; evaluation of Earthquake Safety (Seismic Screening); Revamps in Existing Plants; Inter-disciplinary coordination of project engineering and execution fields; Consulting and Assistance; Conceptual Studies; Stress Analysis of Piping Systems and Piping Supports; Documentation; Training and Supports in CAD-Design, etc. All activities are performed to the greatest extent possible using proven data-processing tools. (author)

  18. An investigation of deformed microstructure and mechanical properties of Zircaloy-4 processed through multiaxial forging

    Energy Technology Data Exchange (ETDEWEB)

    Fuloria, Devasri; Nageswararao, P. [Department of Metallurgical and Materials Engineering & Centre of Nanotechnology, IIT Roorkee, Roorkee 247667 (India); Jayaganthan, R., E-mail: rjayafmt@iitr.ernet.in [Department of Metallurgical and Materials Engineering & Centre of Nanotechnology, IIT Roorkee, Roorkee 247667 (India); Department of Engineering Design, Indian Institute of Technology Madras, Chennai 600036 (India); Jha, S. [Nuclear Fuel Complex Limited, Hyderabad 501301 (India); Srivastava, D. [Materials Science Division, Bhabha Atomic Research Centre, Mumbai 40085 (India)

    2016-04-15

    In the present work, the mechanical behavior of Zircaloy-4 subjected to various deformation strains by multiaxial forging (MAF) at cryogenic temperature (CT) was investigated. The alloy was strained up to different number of cycles, viz., 6 cycles, 9 cycles, and 12 cycles at cumulative strains of 2.96, 4.44, and 5.91, respectively. The mechanical properties of the alloy were investigated by performing the universal tensile test and the Vickers hardness test. Both the test showed improvement in the ultimate tensile strength and hardness value by 51% and 26%, respectively, at the highest cumulative strain of 5.91. The electron backscattered diffraction (EBSD) measurement and transmission electron microscopy (TEM) were used for analyzing the deformed microstructure. The microstructures of the alloy underwent deformation at various cumulative strains/cycles showed grain refinement with the evolution of shear and twin bands that were highest for the alloy deformed at the highest number of cycles. The effective grain refinement was due to twins formation and their intersection, which led to the improvement in mechanical properties of the MAFed alloy, as observed in the present work. - Highlights: • Zircaloy-4 was subjected to MAF at cryogenic temperature. • Microstructural evolution was studied through EBSD and TEM. • Deformed microstructure was marked with various types of twinning and shear banding. • Twins formations are responsible for effective grain refinement and enhanced mechanical properties.

  19. Small-scale multi-axial hybrid simulation of a shear-critical reinforced concrete frame

    Science.gov (United States)

    Sadeghian, Vahid; Kwon, Oh-Sung; Vecchio, Frank

    2017-10-01

    This study presents a numerical multi-scale simulation framework which is extended to accommodate hybrid simulation (numerical-experimental integration). The framework is enhanced with a standardized data exchange format and connected to a generalized controller interface program which facilitates communication with various types of laboratory equipment and testing configurations. A small-scale experimental program was conducted using a six degree-of-freedom hydraulic testing equipment to verify the proposed framework and provide additional data for small-scale testing of shearcritical reinforced concrete structures. The specimens were tested in a multi-axial hybrid simulation manner under a reversed cyclic loading condition simulating earthquake forces. The physical models were 1/3.23-scale representations of a beam and two columns. A mixed-type modelling technique was employed to analyze the remainder of the structures. The hybrid simulation results were compared against those obtained from a large-scale test and finite element analyses. The study found that if precautions are taken in preparing model materials and if the shear-related mechanisms are accurately considered in the numerical model, small-scale hybrid simulations can adequately simulate the behaviour of shear-critical structures. Although the findings of the study are promising, to draw general conclusions additional test data are required.

  20. Development of a Very High Cycle Fatigue (VHCF multiaxial testing device

    Directory of Open Access Journals (Sweden)

    M. Vieira

    2016-07-01

    Full Text Available The very high cycle region of the S-N fatigue curve has been the subject of intensive research on the last years, with special focus on axial, bending, torsional and fretting fatigue tests. Very high cycle fatigue can be achieved using ultrasonic exciters which allow for frequency testing of up to 30 kHz. Still, the multiaxial fatigue analysis is not yet developed for this type of fatigue analyses, mainly due to conceptual limitations of these testing devices. In this paper, a device designed to produce biaxial fatigue testing using a single piezoelectric axial exciter is presented, as well as the preliminary testing of this device. The device is comprised of a horn and a specimen, which are both attached to the piezoelectric exciter. The steps taken towards the final geometry of the device are presented. Preliminary experimental testing of the developed device is made using thermographic imaging, strain measurements and vibration speeds and indicates good behaviour of the tested specimen.

  1. Identification of Time-Varying Pilot Control Behavior in Multi-Axis Control Tasks

    Science.gov (United States)

    Zaal, Peter M. T.; Sweet, Barbara T.

    2012-01-01

    Recent developments in fly-by-wire control architectures for rotorcraft have introduced new interest in the identification of time-varying pilot control behavior in multi-axis control tasks. In this paper a maximum likelihood estimation method is used to estimate the parameters of a pilot model with time-dependent sigmoid functions to characterize time-varying human control behavior. An experiment was performed by 9 general aviation pilots who had to perform a simultaneous roll and pitch control task with time-varying aircraft dynamics. In 8 different conditions, the axis containing the time-varying dynamics and the growth factor of the dynamics were varied, allowing for an analysis of the performance of the estimation method when estimating time-dependent parameter functions. In addition, a detailed analysis of pilots adaptation to the time-varying aircraft dynamics in both the roll and pitch axes could be performed. Pilot control behavior in both axes was significantly affected by the time-varying aircraft dynamics in roll and pitch, and by the growth factor. The main effect was found in the axis that contained the time-varying dynamics. However, pilot control behavior also changed over time in the axis not containing the time-varying aircraft dynamics. This indicates that some cross coupling exists in the perception and control processes between the roll and pitch axes.

  2. Multi-axial strain transfer from laminated CFRP composites to embedded Bragg sensor: I. Parametric study

    International Nuclear Information System (INIS)

    Luyckx, G; Voet, E; De Waele, W; Degrieck, J

    2010-01-01

    Embedded optical fibre sensors are considered in numerous applications for structural health monitoring purposes. However, since the optical fibre and the host material in which it is embedded, will have different material properties, strain in both materials will not be equal when load is applied. Therefore, the multi-axial strain transfer from the host material to the embedded sensor (optical fibre) has to be considered in detail. In the first part of this paper the strain transfer will be determined using finite element modelling of a circular isotropic glass fibre embedded first in an isotropic host and second in an anisotropic composite material. The strain transfer or relation depends on the mechanical properties of the host material and the sensor (Young's modulus and Poisson's ratio), on the lay-up of the composite material (uni-directional lay-up/cross-ply lay-up) and the position of the sensor in a certain layer. In the second part of the paper the developed strain transfer model will be evaluated for one specific lay-up and sensor type

  3. Stress Management

    Science.gov (United States)

    Healthy Lifestyle Stress management By Mayo Clinic Staff Stress basics Stress is a normal psychological and physical reaction to the demands of life. ... some people's alarm systems rarely shut off. Stress management gives you a range of tools to reset ...

  4. Biofeedback systems for stress reduction: Towards a Bright Future for a Revitalized Field

    NARCIS (Netherlands)

    van den Broek, Egon; Westerink, Joyce H.D.M.; Conchon, E.; Correia, C.; Fred, A.; Gamboa, H.

    2012-01-01

    Stress has recently been baptized as the black death of the 21st century, which illustrates its threat to current health standards. This article proposes biofeedback systems as a means to reduce stress. A concise state-ofthe-art introduction on biofeedback systems is given. The field of mental

  5. Biofeedback systems for stress reduction : Towards a bright future for a revitalized field

    NARCIS (Netherlands)

    Broek, E.L. van den; Westerink, J.H.D.M.

    2012-01-01

    Stress has recently been baptized as the black death of the 21st century, which illustrates its threat to current health standards. This article proposes biofeedback systems as a means to reduce stress. A concise state-of-the-art introduction on biofeedback systems is given. The field of mental

  6. Test plan for in situ stress measurement system development

    International Nuclear Information System (INIS)

    Kim, K.

    1981-09-01

    The tests are to be performed to provide information regarding the state of stress of the basalt rock beneath the Hanford Site. This test series is designed to obtain information necessary to determine if hydrofracturing stress measurement is feasible in a fractured basalt medium. During the course of these field tests, it will be attempted to adapt the conventional hydrofracturing test method and analysis techniques to the basalt medium. If the test is shown to be feasible, more holes will be identified for testing. A comprehensive in situ stress determination program will be initiated. 2 figs

  7. The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress.

    Science.gov (United States)

    Corcoran, Louise; Roche, Michelle; Finn, David P

    2015-01-01

    Stress has a complex, bidirectional modulatory influence on pain. Stress may either reduce (stress-induced analgesia) or exacerbate (stress-induced hyperalgesia) pain depending on the nature, duration, and intensity of the stressor. The endogenous cannabinoid (endocannabinoid) system is present throughout the neuroanatomical pathways that mediate and modulate responses to painful stimuli. The specific role of the endocannabinoid system in the brain in pain and the modulation of pain by stress is reviewed herein. We first provide a brief overview of the endocannabinoid system, followed by a review of the evidence that the brain's endocannabinoid system modulates pain. We provide a comprehensive evaluation of the role of the endocannabinoid system supraspinally, and particularly in the rostral ventromedial medulla, periaqueductal gray, amygdala, and prefrontal cortex, in pain, stress-induced analgesia, and stress-induced hyperalgesia. Increased understanding of endocannabinoid-mediated regulation of pain and its modulation by stress will inform the development of novel therapeutic approaches for pain and its comorbidity with stress-related disorders. © 2015 Elsevier Inc. All rights reserved.

  8. User's Guide: Arch Dam Stress Analysis System (ADSAS)

    National Research Council Canada - National Science Library

    1997-01-01

    .... ADSAS assumes linear elastic behavior for the entire dam, i.e. the dam is assumed to support the computed tensile stresses within the concrete mass and across the monolith joints without cracking or opening the joints...

  9. Acoustic Emission Based Surveillance System for Prediction of Stress Fractures

    Science.gov (United States)

    2007-09-01

    aging are susceptible to such fractures in contexts of osteoporosis, diabetes, cerebral palsy, fibrous dysplasia and osteogenesis imperfecta . This...disease, or, healthy people who have excessive exercise regimes (soldiers and athletes) experience these fractures [2]. Stress fractures interrupt

  10. Systemic oxidative stress markers in animal model for depression

    DEFF Research Database (Denmark)

    Bouzinova, Elena; Kravtsova, Violetta; Aalkjær, Christian

    Involvement of oxidative stress (OxS) in development of major depressive disorder has recently become evident, though mechanisms behind this remain elusive. We analyzed therefore OxS pathways in rat Chronic Mild Stress (CMS) model of depression. Rats are exposed to chronic unpredictable mild...... mg/kg/day). Saline injections were done to control the vehicle effect. Escitalopram treated rats were sub-divided into 2 groups: responders and non-responders, according to their hedonic state and compared to non-stressed rats, treated with either saline or Escitalopram. Measurement of total...... glutathione and malondialdehyde (MDA) in lungs, heart, skeletal muscles, liver, saphenous, mesenteric, and tail arteries were used as estimates for OxS. In heart, glutathione was increased in CMS rats in comparison with non-stressed vehicle group. Accordingly, an estimate for free radical activity, MDA...

  11. Microstructure, Slip Systems and Yield Stress Anisotropy in Plastic Deformation

    DEFF Research Database (Denmark)

    Winther, Grethe; You, Ze Sheng; Lu, Lei

    The highly anisotropic microstructures in nanotwinned copper produced by electrodeposition provide an excellent opportunity to evaluate models for microstructurally induced mechanical anisotropy. A crystal plasticity model originally developed for the integration of deformation induced dislocatio...... boundaries with texture is applied to account for the effects of texture as well as twin and grain boundaries, providing good qualitative agreement with experimental yield stress and yield stress anisotropy data....

  12. Local stress calculation in simulations of multicomponent systems

    International Nuclear Information System (INIS)

    Branicio, Paulo S.; Srolovitz, David J.

    2009-01-01

    The virial and Hardy methods provide accurate local stresses for single component materials such as monatomic metals. In contrast to the elemental material case, both methods provide poor estimates of the local stress for multicomponent materials. Using binary materials such as CaO, SiC and AlN and homogeneous strain, we demonstrate that there are several sources for the slow convergence of the virial and Hardy local stresses to the bulk values. Different approaches such as enforced stoichiometry, atomic localization functions and the atomic voronoi volume are used to improve the convergence and increase the spatial resolution of the local stress. The virial method with enforced stoichiometry and atomic voronoi volumes is the most accurate, giving exact stress values by the first atomic shell. In the general case, not assuming stoichiometry, the virial method with localization functions converge to 93% of the bulk value by the third atomic shell. This work may be particularly useful for the real-time description of stresses in simulations of shock waves and deformation dynamics.

  13. Stress.

    Science.gov (United States)

    Chambers, David W

    2008-01-01

    We all experience stress as a regular, and sometimes damaging and sometimes useful, part of our daily lives. In our normal ups and downs, we have our share of exhaustion, despondency, and outrage--matched with their corresponding positive moods. But burnout and workaholism are different. They are chronic, dysfunctional, self-reinforcing, life-shortening habits. Dentists, nurses, teachers, ministers, social workers, and entertainers are especially susceptible to burnout; not because they are hard-working professionals (they tend to be), but because they are caring perfectionists who share control for the success of what they do with others and perform under the scrutiny of their colleagues (they tend to). Workaholics are also trapped in self-sealing cycles, but the elements are ever-receding visions of control and using constant activity as a barrier against facing reality. This essay explores the symptoms, mechanisms, causes, and successful coping strategies for burnout and workaholism. It also takes a look at the general stress response on the physiological level and at some of the damage American society inflicts on itself.

  14. The stress analysis evaluation and pipe support layout for pressurizer discharge system

    International Nuclear Information System (INIS)

    Mao Qing; Wang Wei; Zhang Yixiong

    2000-01-01

    The author presents the stress analysis and evaluation of pipe layout and support adjustment process for Qinshan phase II pressurizer discharge system. Using PDL-SYSPIPE INTERFACE software, the characteristic parameters of the system are gained from 3-D CAD engineering design software PDL and outputted as the input date file format of special pipe stress analysis program SYSPIPE. Based on that, SYSPIPE program fast stress analysis function is applied in adjusting pipe layout , support layout and support types. According to RCC-M standard, the pipe stress analysis and evaluation under deadweight, internal pressure, thermal expansion, seismic, pipe rupture and discharge loads are fulfilled

  15. Thermal stress analysis of gravity support system for ITER based on ANSYS

    International Nuclear Information System (INIS)

    Liang Shangming; Yan Xijiang; Huang Yufeng; Wang Xianzhou; Hou Binglin; Li Pengyuan; Jian Guangde; Liu Dequan; Zhou Caipin

    2009-01-01

    A method for building the finite element model of the gravity support system for International Thermonuclear Experimental Reactor (ITER) was proposed according to the characteristics of the gravity support system with the cyclic symmetry. A mesh dividing method, which has high precision and an acceptable calculating scale, was used, and a three dimensional finite element model for the toroidal 20 degree sector of the gravity support system was built by using ANSYS. Meantime, the steady-state thermal analysis and thermal-structural coupling analysis of the gravity support system were performed. The thermal stress distributions and the maximal thermal stress values of all parts of the gravity support system were obtained, and the stress intensity of parts of the gravity support system was analyzed. The results of thermal stress analysis lay the solid foundation for design and improvement for gravity supports system for ITER. (authors)

  16. The antioxidative system of Norway spruce: Effects of different stress factors. Das antioxidative System der Fichte: Einfluss von verschiedenen Stressfaktoren

    Energy Technology Data Exchange (ETDEWEB)

    Schittenhelm, J. (Freiburg Univ., Inst. fuer Biologie 2, Abt. Botanik (Germany)); Westphal, S. (Freiburg Univ., Inst. fuer Biologie 2, Abt. Botanik (Germany)); Toder, S. (Freiburg Univ., Inst. fuer Biologie 2, Abt. Botanik (Germany)); Wagner, E. (Freiburg Univ., Inst. fuer Biologie 2, Abt. Botanik (Germany))

    1993-08-01

    The effects of different stress factors on the antioxidative system of 6-year-old Norway spruces of the same clone were examined. Flooding and permanent darkness had only minor effects. On the other hand drought, chilling, intense light, and very high ozone concentrations showed strong but distinct consequences. This indicates that the damages by these stress factors are due to different toxic oxygen species, and that the stress factors could produce synergistic damages under natural field conditions. (orig.)

  17. Conceptualizing the dynamics of workplace stress: a systems-based study of nursing aides

    OpenAIRE

    Jetha, Arif; Kernan, Laura; Kurowski, Alicia

    2017-01-01

    Background Workplace stress is a complex phenomenon that may often be dynamic and?evolving over time. Traditional linear modeling does not allow representation of recursive feedback loops among the implicated factors. The objective of this study was to develop a multidimensional system dynamics model (SDM) of workplace stress among nursing aides and conduct simulations to illustrate how changes in psychosocial perceptions and workplace factors might influence workplace stress over time. Metho...

  18. Prolongevity medicine: Antagonic-Stress drug in distress, geriatrics, and related diseases. II. Clinical review--2003.

    Science.gov (United States)

    Riga, S; Riga, D; Schneider, F

    2004-06-01

    Distress and senescence, their reciprocal aggravating-quickening connections, and their related pathologies have a large worldwide impact on healthcare systems in this new millennium. For this reason, Antagonic-Stress (AS)--an advanced integrative therapy, with specific synergistic composition, and patented internationally--represents a significant strategy in health, aging, and longevity. Clinical research with AS proves the drug's efficacy in the management of distress (neurotic, stress-related, and affective disorders; behavioral syndromes associated with physiological disturbances and physical factors; mental and behavioral disorders due to psychoactive substance uses) and psychogeriatrics [organic, including symptomatic, mental disorders (OMD)]. Specific multiaxial psychopathological instruments and psychometric tests in multiple assessments used for gerontopsychiatry demonstrated strong improvements after AS administration in early-moderate stages of Alzheimer or vascular dementia, as well as in other OMD. In addition, comparative clinical studies evinced the superiority of AS (synergistic multitherapy) versus monotherapy [meclofenoxate (MF), piracetam (PA), pyritinol (PT), and nicergoline (NE), respectively]. These comparative clinical trials agreed closely with comparative preclinical research and confirmed AS synergistic homeostatic, adaptogenic, antioxidative, cerebrovascular, neurometabolic, and nootropic actions. Also, the AS protective actions against oxidative stress recommend this orthomolecular therapy in stress, aging, and free radical pathology.

  19. Computational Psychometrics for Modeling System Dynamics during Stressful Disasters

    Directory of Open Access Journals (Sweden)

    Pietro Cipresso

    2017-08-01

    Full Text Available Disasters can be very stressful events. However, computational models of stress require data that might be very difficult to collect during disasters. Moreover, personal experiences are not repeatable, so it is not possible to collect bottom-up information when building a coherent model. To overcome these problems, we propose the use of computational models and virtual reality integration to recreate disaster situations, while examining possible dynamics in order to understand human behavior and relative consequences. By providing realistic parameters associated with disaster situations, computational scientists can work more closely with emergency responders to improve the quality of interventions in the future.

  20. Defining and evaluating heat stress thresholds in different dairy cow production systems

    OpenAIRE

    Brügemann, Kerstin; Gernand, Erhard; König von Borstel, Uta; König, Sven

    2012-01-01

    The aim of this study was to assess the impact of heat stress in dairy cows on test-day records for production traits and somatic cell score (SCS) in the state of Lower Saxony, Germany. Three different production systems were defined: A production system characterized by intensive crop production (=indoor housing), a pasture based production system, and a maritime region. Heat stress was assessed by two temperature-humidity indices (THI) modelled as random regression coefficients in an analys...

  1. Early life stress sensitizes the renal and systemic sympathetic system in rats.

    Science.gov (United States)

    Loria, Analia S; Brands, Michael W; Pollock, David M; Pollock, Jennifer S

    2013-08-01

    We hypothesized that maternal separation (MS), an early life stress model, induces a sensitization of the sympathetic system. To test this hypothesis, we evaluated the renal and systemic sympathetic system in 12- to 14-wk-old male control or MS rats with the following parameters: 1) effect of renal denervation on conscious renal filtration capacity, 2) norepinephrine (NE) content in key organs involved in blood pressure control, and 3) acute systemic pressor responses to adrenergic stimulation or ganglion blockade. MS was performed by separating pups from their mothers for 3 h/day from day 2 to 14; controls were nonhandled littermates. Glomerular filtration rate (GFR) was examined in renal denervated (DnX; within 2 wk) or sham rats using I¹²⁵-iothalamate plasma clearance. MS-DnX rats showed significantly increased GFR compared with MS-SHAM rats (3.8 ± 0.4 vs. 2.4 ± 0.2 ml/min, respectively, P renal nerves regulate GFR in MS rats. NE content was significantly increased in organ tissues from MS rats (P renal and systemic sympathetic system. Conscious MS rats displayed a significantly greater increase in mean arterial pressure (MAP) in response to NE (2 μg/kg ip) and a greater reduction in MAP in response to mecamylamine (2 mg/kg ip, P renal and systemic sympathetic system ultimately impairing blood pressure regulation.

  2. Stress in film/substrate system due to diffusion and thermal misfit effects

    International Nuclear Information System (INIS)

    Shao Shanshan; Xuan Fuzhen; Wang Zhengdong; Tu Shantung

    2009-01-01

    The stress in film/substrate systems has been analysed taking into consideration the coupling effects of diffusion and thermal misfit within the framework of Fick's second law. The solution of diffusion-induced stress in a film/substrate system involving the thermal misfit stress feedback is developed. The effects of modulus ratios, diffusivity ratios, thickness ratios of the substrate and the film and the partial molar volume of the diffusing component on the stress distribution in the film/substrate system are then discussed with the help of the finite difference method. Results indicate that the stresses in the film/substrate system vary with diffusion time. Diffusion enhances the magnitudes of film stress when the thermal misfit stress is compressive in the film. Furthermore, the absolute values of stress in the film increase with the increasing modulus ratios of the substrate and film, while they reduce with the increasing partial molar volume of the diffusing component and the diffusivity ratio of the substrate and the film.

  3. Job-Stress and Burnout of the Venezuelan Teachers: Related to Educational Systems Change (Educacion Basica).

    Science.gov (United States)

    Kim, Young Mi; And Others

    Beginning with a review of the increasing literature concerning job-related teacher stress, this study examines the particular stress and burnout experiences of school teachers in Venezuela since the incorporation by law in 1980 of "Educacion Basica" (basic education) as a new level of the school system (grades 1-9). To compare teachers…

  4. Biological stress systems, adverse life events and the onset of chronic multisite musculoskeletal pain : a six-year cohort study

    NARCIS (Netherlands)

    Generaal, E.; Vogelzangs, N.; Macfarlane, G.J.; Geenen, R.; de Geus, E.; Smit, J.H.; Penninx, B.W.; Dekker, J.

    2015-01-01

    Background Dysregulated biological stress systems and adverse life events, both independently and in interaction, have been hypothesized to initiate chronic pain. Objectives We examine whether (i) function of biological stress systems, (ii) adverse life events, and (iii) their combination predict

  5. Global Stress Classification System for Materials Used in Solar Energy Applications

    Science.gov (United States)

    Slamova, Karolina; Schill, Christian; Herrmann, Jan; Datta, Pawan; Chih Wang, Chien

    2016-08-01

    Depending on the geographical location, the individual or combined impact of environmental stress factors and corresponding performance losses for solar applications varies significantly. Therefore, as a strategy to reduce investment risks and operating and maintenance costs, it is necessary to adapt the materials and components of solar energy systems specifically to regional environmental conditions. The project «GloBe Solar» supports this strategy by focusing on the development of a global stress classification system for materials in solar energy applications. The aim of this classification system is to assist in the identification of the individual stress conditions for every location on the earth's surface. The stress classification system could serve as a decision support tool for the industry (manufacturers, investors, lenders and project developers) and help to improve knowledge and services that can provide higher confidence to solar power systems.

  6. Computational stress and damage modelling for rolling contact fatigue

    DEFF Research Database (Denmark)

    Cerullo, Michele

    Rolling contact fatigue in radial roller bearings is studied by means of a 2D plane strain nite element program. The Dang Van multiaxial fatigue criterion is firstly used, in a macroscopic study modeling the bearing raceway, to investigate the region where fatigue cracks are more likely to nucleate...... and of compressive residual stresses are also analyzed. The stress history of a material point at the depth where the maximum Dang Van damage factor is reached is then recorded and used in a subsequent micro-mechanical analysis. The stress history is applied as periodic boundary conditions in a representative volume...

  7. Higher efficiency by direct driven spindles with sensorless controlled engine speed in multi-axial machine tools for the timber industry; Verbesserte Energieeffizienz durch direktangetriebene winkelgeberlose drehzahlgeregelte Spindeln bei Mehrachsbohrkoepfen fuer die holzverarbeitende Industrie

    Energy Technology Data Exchange (ETDEWEB)

    Teisch, Arthur; Obernolte, Urs; Borcherding, Holger [Hochschule Ostwestfalen Lippe, Lemgo (Germany)

    2009-07-01

    The multi-axial machine tools work mainly with spindles, who are powered by a central motor with a gearbox. These drives have a relative little power efficiency. Due to the progress of the magnetic material it was possible to change the central motor with gear box by small direct driven spindles. Cause of the very high efficiency of the permanentmagnet synchronous machine (PMSM), it is the best option for the new application. With the option of the sensorless control of the rotor speed the costs for an encoder are saved too. With the good efficiency of the PMSM the overall degree of efficiency could be raised by about 70%. Because of the reduced investment, service and energy costs the new systems are more economical to operate. (orig.)

  8. Effect of honey on the reproductive system of male rat offspring exposed to prenatal restraint stress.

    Science.gov (United States)

    Haron, M N; Mohamed, M

    2016-06-01

    Exposure to prenatal stress is associated with impaired reproductive function in male rat offspring. Honey is traditionally used by the Malays for enhancement of fertility. The aim of this study was to determine the effect of honey on reproductive system of male rat offspring exposed to prenatal restraint stress. Dams were divided into four groups (n = 10/group): control, honey, stress and honey + stress groups. Dams from honey and honey + stress groups received oral honey (1.2 g kg(-1) body weight) daily from day 1 of pregnancy, meanwhile dams from stress and honey + stress groups were subjected to restraint stress (three times per day) from day 11 of pregnancy until delivery. At 10 weeks old, each male rat offspring was mated with a regular oestrus cycle female. Male sexual behaviour and reproductive performance were evaluated. Then, male rats were euthanised for assessment on reproductive parameters. Honey supplementation during prenatal restraint stress significantly increased testis and epididymis weights as well as improved the percentages of abnormal spermatozoa and sperm motility in male rat offspring. In conclusion, this study might suggest that supplementation of honey during pregnancy seems to reduce the adverse effects of restraint stress on reproductive organs weight and sperm parameters in male rat offspring. © 2015 Blackwell Verlag GmbH.

  9. A study on the stress history condensation method for a fatigue monitoring system

    International Nuclear Information System (INIS)

    Ko, Hanok; Jhung, Myungjo; Lee, Kihyoung

    2014-01-01

    Fatigue damage is the one of important aging mechanisms. Time-varying thermal, pressure and mechanical loads produce perturbations of stress cycles primarily at the surface of a component. Stress cycles of sufficient magnitude cause fatigue damage, which can ultimately lead to cracking of the component. According to NUREG-1801, fatigue monitoring systems identify acceptable aging management programs, including programs for fatigue and cyclic operation. In a monitoring system, the rainflow counting method is mainly used as the stress cycle counting method. Before determining the stress cycles using rainflow counting method, stress extremum (or peak/valley) must be identified. Because real stress history contains large numbers of very small cycles, which may be a result of digitization noise, these cycles will slow down the analysis and distort the scaling of graphical displays. As a result, it is found that stress cycles smaller than a threshold value are discarded by using the proposed method. In this paper, an engineering methodology which extracts extremum from the real-time transient data, so-called SEE, has been developed. The proposed method is very simple and so fast because it only uses the difference between the input value and local peak/valley. The stress cycles counted by two methods are compared with those counted by only rainflow counting method and it is found that stress cycles smaller than a threshold value were eliminated

  10. Restraint stress enhances arterial thrombosis in vivo--role of the sympathetic nervous system.

    Science.gov (United States)

    Stämpfli, Simon F; Camici, Giovanni G; Keller, Stephan; Rozenberg, Izabela; Arras, Margarete; Schuler, Beat; Gassmann, Max; Garcia, Irene; Lüscher, Thomas F; Tanner, Felix C

    2014-01-01

    Stress is known to correlate with the incidence of acute myocardial infarction. However, the molecular mechanisms underlying this correlation are not known. This study was designed to assess the effect of experimental stress on arterial thrombus formation, the key event in acute myocardial infarction. Mice exposed to 20 h of restraint stress displayed an increased arterial prothrombotic potential as assessed by photochemical injury-induced time to thrombotic occlusion. This increase was prevented by chemical sympathectomy performed through 6-hydroxydopamine (6-OHDA). Blood-born tissue factor (TF) activity was enhanced by stress and this increase could be prevented by 6-OHDA treatment. Vessel wall TF, platelet count, platelet aggregation, coagulation times (PT, aPTT), fibrinolytic system (t-PA and PAI-1) and tail bleeding time remained unaltered. Telemetric analysis revealed only minor hemodynamic changes throughout the stress protocol. Plasma catecholamines remained unaffected after restraint stress. Tumor necrosis factor alpha (TNF-α) plasma levels were unchanged and inhibition of TNF-α had no effect on stress-enhanced thrombosis. These results indicate that restraint stress enhances arterial thrombosis via the sympathetic nervous system. Blood-borne TF contributes, at least in part, to the observed effect whereas vessel wall TF, platelets, circulating coagulation factors, fibrinolysis and inflammation do not appear to play a role. These findings shed new light on the understanding of stress-induced cardiovascular events.

  11. IEA-R1 renewed primary coolant piping system stress analysis

    International Nuclear Information System (INIS)

    Fainer, Gerson; Faloppa, Altair A.; Oliveira, Carlos A. de; Mattar Neto, Miguel

    2015-01-01

    A partial replacement of the IEA-R1 piping system was conducted in 2014. The aim of this work is to perform the stress analysis of the renewed primary piping system of the IEA-R1, taking into account the as built conditions and the pipe modifications. The nuclear research reactor IEA-R1 is a pool type reactor designed by Babcox-Willcox, which is operated by IPEN since 1957. The primary coolant system is responsible for removing the residual heat of the Reactor core. As a part of the life management, a regular inspection detected some degradation in the primary piping system. In consequence, part of the piping system was replaced. The partial renewing of the primary piping system did not imply in major piping layout modifications. However, the stress condition of the piping systems had to be reanalyzed. The structural stress analysis of the primary piping systems is now presented and the final results are discussed. (author)

  12. Coordinated Actions of Glyoxalase and Antioxidant Defense Systems in Conferring Abiotic Stress Tolerance in Plants

    Directory of Open Access Journals (Sweden)

    Mirza Hasanuzzaman

    2017-01-01

    Full Text Available Being sessile organisms, plants are frequently exposed to various environmental stresses that cause several physiological disorders and even death. Oxidative stress is one of the common consequences of abiotic stress in plants, which is caused by excess generation of reactive oxygen species (ROS. Sometimes ROS production exceeds the capacity of antioxidant defense systems, which leads to oxidative stress. In line with ROS, plants also produce a high amount of methylglyoxal (MG, which is an α-oxoaldehyde compound, highly reactive, cytotoxic, and produced via different enzymatic and non-enzymatic reactions. This MG can impair cells or cell components and can even destroy DNA or cause mutation. Under stress conditions, MG concentration in plants can be increased 2- to 6-fold compared with normal conditions depending on the plant species. However, plants have a system developed to detoxify this MG consisting of two major enzymes: glyoxalase I (Gly I and glyoxalase II (Gly II, and hence known as the glyoxalase system. Recently, a novel glyoxalase enzyme, named glyoxalase III (Gly III, has been detected in plants, providing a shorter pathway for MG detoxification, which is also a signpost in the research of abiotic stress tolerance. Glutathione (GSH acts as a co-factor for this system. Therefore, this system not only detoxifies MG but also plays a role in maintaining GSH homeostasis and subsequent ROS detoxification. Upregulation of both Gly I and Gly II as well as their overexpression in plant species showed enhanced tolerance to various abiotic stresses including salinity, drought, metal toxicity, and extreme temperature. In the past few decades, a considerable amount of reports have indicated that both antioxidant defense and glyoxalase systems have strong interactions in conferring abiotic stress tolerance in plants through the detoxification of ROS and MG. In this review, we will focus on the mechanisms of these interactions and the coordinated

  13. Coordinated Actions of Glyoxalase and Antioxidant Defense Systems in Conferring Abiotic Stress Tolerance in Plants

    Science.gov (United States)

    Hasanuzzaman, Mirza; Nahar, Kamrun; Hossain, Md. Shahadat; Mahmud, Jubayer Al; Rahman, Anisur; Inafuku, Masashi; Oku, Hirosuke; Fujita, Masayuki

    2017-01-01

    Being sessile organisms, plants are frequently exposed to various environmental stresses that cause several physiological disorders and even death. Oxidative stress is one of the common consequences of abiotic stress in plants, which is caused by excess generation of reactive oxygen species (ROS). Sometimes ROS production exceeds the capacity of antioxidant defense systems, which leads to oxidative stress. In line with ROS, plants also produce a high amount of methylglyoxal (MG), which is an α-oxoaldehyde compound, highly reactive, cytotoxic, and produced via different enzymatic and non-enzymatic reactions. This MG can impair cells or cell components and can even destroy DNA or cause mutation. Under stress conditions, MG concentration in plants can be increased 2- to 6-fold compared with normal conditions depending on the plant species. However, plants have a system developed to detoxify this MG consisting of two major enzymes: glyoxalase I (Gly I) and glyoxalase II (Gly II), and hence known as the glyoxalase system. Recently, a novel glyoxalase enzyme, named glyoxalase III (Gly III), has been detected in plants, providing a shorter pathway for MG detoxification, which is also a signpost in the research of abiotic stress tolerance. Glutathione (GSH) acts as a co-factor for this system. Therefore, this system not only detoxifies MG but also plays a role in maintaining GSH homeostasis and subsequent ROS detoxification. Upregulation of both Gly I and Gly II as well as their overexpression in plant species showed enhanced tolerance to various abiotic stresses including salinity, drought, metal toxicity, and extreme temperature. In the past few decades, a considerable amount of reports have indicated that both antioxidant defense and glyoxalase systems have strong interactions in conferring abiotic stress tolerance in plants through the detoxification of ROS and MG. In this review, we will focus on the mechanisms of these interactions and the coordinated action of

  14. Dynamical System Analysis of Reynolds Stress Closure Equations

    Science.gov (United States)

    Girimaji, Sharath S.

    1997-01-01

    In this paper, we establish the causality between the model coefficients in the standard pressure-strain correlation model and the predicted equilibrium states for homogeneous turbulence. We accomplish this by performing a comprehensive fixed point analysis of the modeled Reynolds stress and dissipation rate equations. The results from this analysis will be very useful for developing improved pressure-strain correlation models to yield observed equilibrium behavior.

  15. Mineralocorticoid receptor blockade prevents stress-induced modulation of multiple memory systems in the human brain.

    Science.gov (United States)

    Schwabe, Lars; Tegenthoff, Martin; Höffken, Oliver; Wolf, Oliver T

    2013-12-01

    Accumulating evidence suggests that stress may orchestrate the engagement of multiple memory systems in the brain. In particular, stress is thought to favor dorsal striatum-dependent procedural over hippocampus-dependent declarative memory. However, the neuroendocrine mechanisms underlying these modulatory effects of stress remain elusive, especially in humans. Here, we targeted the role of the mineralocorticoid receptor (MR) in the stress-induced modulation of dorsal striatal and hippocampal memory systems in the human brain using a combination of event-related functional magnetic resonance imaging and pharmacologic blockade of the MR. Eighty healthy participants received the MR antagonist spironolactone (300 mg) or a placebo and underwent a stressor or control manipulation before they performed, in the scanner, a classification task that can be supported by the hippocampus and the dorsal striatum. Stress after placebo did not affect learning performance but reduced explicit task knowledge and led to a relative increase in the use of more procedural learning strategies. At the neural level, stress promoted striatum-based learning at the expense of hippocampus-based learning. Functional connectivity analyses showed that this shift was associated with altered coupling of the amygdala with the hippocampus and dorsal striatum. Mineralocorticoid receptor blockade before stress prevented the stress-induced shift toward dorsal striatal procedural learning, same as the stress-induced alterations of amygdala connectivity with hippocampus and dorsal striatum, but resulted in significantly impaired performance. Our findings indicate that the stress-induced shift from hippocampal to dorsal striatal memory systems is mediated by the amygdala, required to preserve performance after stress, and dependent on the MR. © 2013 Society of Biological Psychiatry.

  16. Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress.

    Science.gov (United States)

    Hodes, Georgia E; Pfau, Madeline L; Leboeuf, Marylene; Golden, Sam A; Christoffel, Daniel J; Bregman, Dana; Rebusi, Nicole; Heshmati, Mitra; Aleyasin, Hossein; Warren, Brandon L; Lebonté, Benoit; Horn, Sarah; Lapidus, Kyle A; Stelzhammer, Viktoria; Wong, Erik H F; Bahn, Sabine; Krishnan, Vaishnav; Bolaños-Guzman, Carlos A; Murrough, James W; Merad, Miriam; Russo, Scott J

    2014-11-11

    Depression and anxiety disorders are associated with increased release of peripheral cytokines; however, their functional relevance remains unknown. Using a social stress model in mice, we find preexisting individual differences in the sensitivity of the peripheral immune system that predict and promote vulnerability to social stress. Cytokine profiles were obtained 20 min after the first social stress exposure. Of the cytokines regulated by stress, IL-6 was most highly up-regulated only in mice that ultimately developed a susceptible behavioral phenotype following a subsequent chronic stress, and levels remained elevated for at least 1 mo. We confirmed a similar elevation of serum IL-6 in two separate cohorts of patients with treatment-resistant major depressive disorder. Before any physical contact in mice, we observed individual differences in IL-6 levels from ex vivo stimulated leukocytes that predict susceptibility versus resilience to a subsequent stressor. To shift the sensitivity of the peripheral immune system to a pro- or antidepressant state, bone marrow (BM) chimeras were generated by transplanting hematopoietic progenitor cells from stress-susceptible mice releasing high IL-6 or from IL-6 knockout (IL-6(-/-)) mice. Stress-susceptible BM chimeras exhibited increased social avoidance behavior after exposure to either subthreshold repeated social defeat stress (RSDS) or a purely emotional stressor termed witness defeat. IL-6(-/-) BM chimeric and IL-6(-/-) mice, as well as those treated with a systemic IL-6 monoclonal antibody, were resilient to social stress. These data establish that preexisting differences in stress-responsive IL-6 release from BM-derived leukocytes functionally contribute to social stress-induced behavioral abnormalities.

  17. Multiaxial fatigue criterion for 2-1/4 Cr-1 Mo steel for use in high-temperature structural design

    International Nuclear Information System (INIS)

    Blass, J.J.

    1990-01-01

    An improved multiaxial fatigue failure criterion is described that is based on a definition of equivalent inelastic strain range incorporating the shear and normal components of inelastic strain range on the planes of maximum inelastic shear strain range. Optimum values of certain parameters contained in the formulation were obtained by the method of least squares from the results of combined axial-torsional strain cycling test of 2--1/4 Cr-1 Mo steel conducted at 538 degrees C (1000 degrees F). The ability of this criterion to correlate the test results was compared with that of the Mises equivalent inelastic strain range criterion and was found to be superior. A procedure is described for calculating the required shear and normal components of strain range under general multiaxial strain cycling conditions. An improved definition of equivalent total strain range based on these considerations is directly applicable to the method of estimating fatigue damage in ASME Code Case N-47. 17 refs., 5 figs., 1 tab

  18. Multiaxial mechanical properties and constitutive modeling of human adipose tissue: a basis for preoperative simulations in plastic and reconstructive surgery.

    Science.gov (United States)

    Sommer, Gerhard; Eder, Maximilian; Kovacs, Laszlo; Pathak, Heramb; Bonitz, Lars; Mueller, Christoph; Regitnig, Peter; Holzapfel, Gerhard A

    2013-11-01

    A preoperative simulation of soft tissue deformations during plastic and reconstructive surgery is desirable to support the surgeon's planning and to improve surgical outcomes. The current development of constitutive adipose tissue models, for the implementation in multilayer computational frameworks for the simulation of human soft tissue deformations, has proved difficult because knowledge of the required mechanical parameters of fat tissue is limited. Therefore, for the first time, human abdominal adipose tissues were mechanically investigated by biaxial tensile and triaxial shear tests. The results of this study suggest that human abdominal adipose tissues under quasi-static and dynamic multiaxial loadings can be characterized as a nonlinear, anisotropic and viscoelastic soft biological material. The nonlinear and anisotropic features are consequences of the material's collagenous microstructure. The aligned collagenous septa observed in histological investigations causes the anisotropy of the tissue. A hyperelastic model used in this study was appropriate to represent the quasi-static multiaxial mechanical behavior of fat tissue. The constitutive parameters are intended to serve as a basis for soft tissue simulations using the finite element method, which is an apparent method for obtaining promising results in the field of plastic and reconstructive surgery. Copyright © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  19. A generic validation methodology and its application to a set of multi-axial creep damage constitutive equations

    International Nuclear Information System (INIS)

    Xu Qiang

    2005-01-01

    A generic validation methodology for a set of multi-axial creep damage constitutive equations is proposed and its use is illustrated with 0.5Cr0.5Mo0.25V ferritic steel which is featured as brittle or intergranular rupture. The objective of this research is to develop a methodology to guide systematically assess the quality of a set of multi-axial creep damage constitutive equations in order to ensure its general applicability. This work adopted a total quality assurance approach and expanded as a Four Stages procedure (Theories and Fundamentals, Parameter Identification, Proportional Load, and Non-proportional load). Its use is illustrated with 0.5Cr0.5Mo0.25V ferritic steel and this material is chosen due to its industry importance, the popular use of KRH type of constitutive equations, and the available qualitative experimental data including damage distribution from notched bar test. The validation exercise clearly revealed the deficiencies existed in the KRH formulation (in terms of mathematics and physics of damage mechanics) and its incapability to predict creep deformation accurately. Consequently, its use should be warned, which is particularly important due to its wide use as indicated in literature. This work contributes to understand the rational for formulation and the quality assurance of a set of constitutive equations in creep damage mechanics as well as in general damage mechanics. (authors)

  20. Regulation of hippocampal neurogenesis by systemic factors including stress, glucocorticoids, sleep, and inflammation

    NARCIS (Netherlands)

    Lucassen, P.J.; Oomen, C.; van Dam, A.-M.; Czéh, B.; Gage, F.H.; Kempermann, G.; Song, H.

    2008-01-01

    This review summarizes and discusses the regulation of adult neurogenesis and hippocampal cellular plasticity by systemic factors. We focus on the role of stress, glucocorticoids, and related factors such as sleep deprivation and inflammation.

  1. Automated Slicing for a Multi-Axis Metal Deposition System (Preprint)

    Science.gov (United States)

    2006-09-01

    experimented with different materials like H13 tool steel to build the part. Following the same slicing and scanning toolpath result, there is a geometric...and analysis tool -centroidal axis. Similar to medial axis, it contains geometry and topological information but is significantly computationally...geometry reasoning and analysis tool -centroidal axis. Similar to medial axis, it contains geometry and topological information but is significantly

  2. Drug-induced and genetic alterations in stress-responsive systems: Implications for specific addictive diseases.

    Science.gov (United States)

    Zhou, Yan; Proudnikov, Dmitri; Yuferov, Vadim; Kreek, Mary Jeanne

    2010-02-16

    From the earliest work in our laboratory, we hypothesized, and with studies conducted in both clinical research and animal models, we have shown that drugs of abuse, administered or self-administered, on a chronic basis, profoundly alter stress-responsive systems. Alterations of expression of specific genes involved in stress responsivity, with increases or decreases in mRNA levels, receptor, and neuropeptide levels, and resultant changes in hormone levels, have been documented to occur after chronic intermittent exposure to heroin, morphine, other opiates, cocaine, other stimulants, and alcohol in animal models and in human molecular genetics. The best studied of the stress-responsive systems in humans and mammalian species in general is undoubtedly the HPA axis. In addition, there are stress-responsive systems in other parts in the brain itself, and some of these include components of the HPA axis, such as CRF and CRF receptors, along with POMC gene and gene products. Several other stress-responsive systems are known to influence the HPA axis, such as the vasopressin-vasopressin receptor system. Orexin-hypocretin, acting at its receptors, may effect changes which suggest that it should be properly categorized as a stress-responsive system. However, less is known about the interactions and connectivity of some of these different neuropeptide and receptor systems, and in particular, about the possible connectivity of fast-acting (e.g., glutamate and GABA) and slow-acting (including dopamine, serotonin, and norepinephrine) neurotransmitters with each of these stress-responsive components and the resultant impact, especially in the setting of chronic exposure to drugs of abuse. Several of these stress-responsive systems and components, primarily based on our laboratory-based and human molecular genetics research of addictive diseases, will be briefly discussed in this review. Copyright 2009 Elsevier B.V. All rights reserved.

  3. Acute stress-induced cortisol elevations mediate reward system activity during subconscious processing of sexual stimuli.

    Science.gov (United States)

    Oei, Nicole Y L; Both, Stephanie; van Heemst, Diana; van der Grond, Jeroen

    2014-01-01

    Stress is thought to alter motivational processes by increasing dopamine (DA) secretion in the brain's "reward system", and its key region, the nucleus accumbens (NAcc). However, stress studies using functional magnetic resonance imaging (fMRI), mainly found evidence for stress-induced decreases in NAcc responsiveness toward reward cues. Results from both animal and human PET studies indicate that the stress hormone cortisol may be crucial in the interaction between stress and dopaminergic actions. In the present study we therefore investigated whether cortisol mediated the effect of stress on DA-related responses to -subliminal-presentation of reward cues using the Trier Social Stress Test (TSST), which is known to reliably enhance cortisol levels. Young healthy males (n = 37) were randomly assigned to the TSST or control condition. After stress induction, brain activation was assessed using fMRI during a backward-masking paradigm in which potentially rewarding (sexual), emotionally negative and neutral stimuli were presented subliminally, masked by pictures of inanimate objects. A region of interest analysis showed that stress decreased activation in the NAcc in response to masked sexual cues (voxel-corrected, pcortisol levels were related to stronger NAcc activation, showing that cortisol acted as a suppressor variable in the negative relation between stress and NAcc activation. The present findings indicate that cortisol is crucially involved in the relation between stress and the responsiveness of the reward system. Although generally stress decreases activation in the NAcc in response to rewarding stimuli, high stress-induced cortisol levels suppress this relation, and are associated with stronger NAcc activation. Individuals with a high cortisol response to stress might on one hand be protected against reductions in reward sensitivity, which has been linked to anhedonia and depression, but they may ultimately be more vulnerable to increased reward

  4. Multi-Axis Prosthetic Knee Resembles Alpine Skiing Movements of an Intact Leg

    Directory of Open Access Journals (Sweden)

    Ivan Demšar, Jože Duhovnik, Blaž Lešnik, Matej Supej

    2015-12-01

    Full Text Available The purpose of the study was to analyse the flexion angles of the ski boot, ankle and knee joints of an above-knee prosthesis and to compare them with an intact leg and a control group of skiers. One subject with an above-knee amputation of the right leg and eight healthy subjects simulated the movement of a skiing turn by performing two-leg squats in laboratory conditions. By adding additional loads in proportion to body weight (BW; +1/3 BW, +2/3 BW, +3/3 BW, various skiing regimes were simulated. Change of Flexion Angle (CoFA and Range of Motion (RoM in the ski boot, ankle and knee joints were calculated and compared. An average RoM in the skiing boot on the side of prosthesis (4.4 ± 1.1° was significantly lower compared to an intact leg (5.9 ± 1.8° and the control group (6.5 ± 2.3°. In the ankle joint, the average RoM was determined to be 13.2±2.9° in the prosthesis, 12.7 ± 2.8° in an intact leg and 14.8±3.6 in the control group. However, the RoM of the knee joint in the prosthesis (42.2 ± 4.2° was significantly larger than that of the intact leg (34.7 ± 4.4°. The average RoM of the knee joint in the control group was 47.8 ± 5.4°. The influences of additional loads on the kinematics of the lower extremities were different on the side of the prosthesis and on the intact leg. In contrast, additional loads did not produce any significant differences in the control group. Although different CoFAs in the ski boot, ankle and knee joints were used, an above-knee prosthesis with a built-in multi-axis prosthetic knee enables comparable leg kinematics in simulated alpine skiing.

  5. Stress and the engagement of multiple memory systems: integration of animal and human studies.

    Science.gov (United States)

    Schwabe, Lars

    2013-11-01

    Learning and memory can be controlled by distinct memory systems. How these systems are coordinated to optimize learning and behavior has long been unclear. Accumulating evidence indicates that stress may modulate the engagement of multiple memory systems. In particular, rodent and human studies demonstrate that stress facilitates dorsal striatum-dependent "habit" memory, at the expense of hippocampus-dependent "cognitive" memory. Based on these data, a model is proposed which states that the impact of stress on the relative use of multiple memory systems is due to (i) differential effects of hormones and neurotransmitters that are released during stressful events on hippocampal and dorsal striatal memory systems, thus changing the relative strength of and the interactions between these systems, and (ii) a modulatory influence of the amygdala which biases learning toward dorsal striatum-based memory after stress. This shift to habit memory after stress can be adaptive with respect to current performance but might contribute to psychopathology in vulnerable individuals. Copyright © 2013 Wiley Periodicals, Inc.

  6. Statistical Analysis of Stress Signals from Bridge Monitoring by FBG System

    Directory of Open Access Journals (Sweden)

    Xiao-Wei Ye

    2018-02-01

    Full Text Available In this paper, a fiber Bragg grating (FBG-based stress monitoring system instrumented on an orthotropic steel deck arch bridge is demonstrated. The FBG sensors are installed at two types of critical fatigue-prone welded joints to measure the strain and temperature signals. A total of 64 FBG sensors are deployed around the rib-to-deck and rib-to-diagram areas at the mid-span and quarter-span of the investigated orthotropic steel bridge. The local stress behaviors caused by the highway loading and temperature effect during the construction and operation periods are presented with the aid of a wavelet multi-resolution analysis approach. In addition, the multi-modal characteristic of the rainflow counted stress spectrum is modeled by the method of finite mixture distribution together with a genetic algorithm (GA-based parameter estimation approach. The optimal probability distribution of the stress spectrum is determined by use of Bayesian information criterion (BIC. Furthermore, the hot spot stress of the welded joint is calculated by an extrapolation method recommended in the specification of International Institute of Welding (IIW. The stochastic characteristic of stress concentration factor (SCF of the concerned welded joint is addressed. The proposed FBG-based stress monitoring system and probabilistic stress evaluation methods can provide an effective tool for structural monitoring and condition assessment of orthotropic steel bridges.

  7. Effects of emotional and perceptual-motor stress on a voice recognition system's accuracy: An applied investigation

    Science.gov (United States)

    Poock, G. K.; Martin, B. J.

    1984-02-01

    This was an applied investigation examining the ability of a speech recognition system to recognize speakers' inputs when the speakers were under different stress levels. Subjects were asked to speak to a voice recognition system under three conditions: (1) normal office environment, (2) emotional stress, and (3) perceptual-motor stress. Results indicate a definite relationship between voice recognition system performance and the type of low stress reference patterns used to achieve recognition.

  8. Oxidative Stress and Immune System in Vitiligo and Thyroid Diseases

    Science.gov (United States)

    Colucci, Roberta; Dragoni, Federica

    2015-01-01

    Vitiligo is an acquired dermatological disease frequently associated with autoimmune thyroid disorders. Several theories have been proposed so far to unravel the complex vitiligo pathogenesis. Currently, the autocytotoxic and the autoimmune theories are the most accredited hypothesis, since they are sustained by several important clinical and experimental evidences. A growing body of evidences shows that autoimmunity and oxidative stress strictly interact to finally determine melanocyte loss. In this scenario, associated thyroid autoimmunity might play an active and important role in triggering and maintaining the depigmentation process of vitiligo. PMID:25838868

  9. Neuroscience of opiates for addiction medicine: From stress-responsive systems to behavior.

    Science.gov (United States)

    Zhou, Yan; Leri, Francesco

    2016-01-01

    Opiate addiction, similarly to addiction to other psychoactive drugs, is chronic relapsing brain disease caused by drug-induced short-term and long-term neuroadaptations at the molecular, cellular, and behavioral levels. Preclinical research in laboratory animals has found important interactions between opiate exposure and stress-responsive systems. In this review, we will discuss the dysregulation of several stress-responsive systems in opiate addiction: vasopressin and its receptor system, endogenous opioid systems (including proopiomelanocortin/mu opioid receptor and dynorphin/kappa opioid receptor), orexin and its receptor system, and the hypothalamic-pituitary-adrenal axis. A more complete understanding of how opiates alter these stress systems, through further laboratory-based studies, is required to identify novel and effective pharmacological targets for the long-term treatment of heroin addiction. © 2016 Elsevier B.V. All rights reserved.

  10. Pipe stress analysis on HCCR-TBS ancillary systems in conceptual design

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Mu-Young, E-mail: myahn74@nfri.re.kr [National Fusion Research Institute, Daejeon (Korea, Republic of); Cho, Seungyon [National Fusion Research Institute, Daejeon (Korea, Republic of); Lee, Eo Hwak [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Park, Yi-Hyun; Lee, Youngmin [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2016-11-01

    Highlights: • Pipe stress is performed on Korean HCCR-TBS for the load combinations including seismic events. • The resultant stress meets the requirement of the design code & standard except one position where modification is needed. • The results gives useful information for the design evolution in the next desgin phase. - Abstract: Korean Helium Cooled Ceramic Reflector (HCCR) Test Blanket System (TBS) will be tested in ITER to demonstrate feasibility of the breeding blanket concept. The HCCR-TBS comprises Test Blanket Module (TBM) with associated shield, and ancillary systems located in various positions of ITER building. Currently, conceptual design for the HCCR-TBS is in progress. This paper presents pipe stress analysis results for the HCCR-TBS ancillary systems. The pipe stress analysis was performed in accordance with ASME B31.3 for major pipes of the Helium Cooling System (HCS) and the Coolant Purification System (CPS), which are operated in high pressure and temperature. The pipe stress for various load cases and load combinations were calculated. Operational pressure and temperature during plasma operation are applied as pressure load and thermal load, respectively. In addition seismic events were combined to investigate the code compliance for sustained load case and occasional load case. It was confirmed that the resultant stress meets the requirements of ASME B31.3 except one position in which it needs modification. These results give useful information for the next design phase, for example, nozzle loads for the component selection, the support design parameters, etc.

  11. Pipe stress analysis on HCCR-TBS ancillary systems in conceptual design

    International Nuclear Information System (INIS)

    Ahn, Mu-Young; Cho, Seungyon; Lee, Eo Hwak; Park, Yi-Hyun; Lee, Youngmin

    2016-01-01

    Highlights: • Pipe stress is performed on Korean HCCR-TBS for the load combinations including seismic events. • The resultant stress meets the requirement of the design code & standard except one position where modification is needed. • The results gives useful information for the design evolution in the next desgin phase. - Abstract: Korean Helium Cooled Ceramic Reflector (HCCR) Test Blanket System (TBS) will be tested in ITER to demonstrate feasibility of the breeding blanket concept. The HCCR-TBS comprises Test Blanket Module (TBM) with associated shield, and ancillary systems located in various positions of ITER building. Currently, conceptual design for the HCCR-TBS is in progress. This paper presents pipe stress analysis results for the HCCR-TBS ancillary systems. The pipe stress analysis was performed in accordance with ASME B31.3 for major pipes of the Helium Cooling System (HCS) and the Coolant Purification System (CPS), which are operated in high pressure and temperature. The pipe stress for various load cases and load combinations were calculated. Operational pressure and temperature during plasma operation are applied as pressure load and thermal load, respectively. In addition seismic events were combined to investigate the code compliance for sustained load case and occasional load case. It was confirmed that the resultant stress meets the requirements of ASME B31.3 except one position in which it needs modification. These results give useful information for the next design phase, for example, nozzle loads for the component selection, the support design parameters, etc.

  12. A Presence-Based Context-Aware Chronic Stress Recognition System

    Directory of Open Access Journals (Sweden)

    Andrej Kos

    2012-11-01

    Full Text Available Stressors encountered in daily life may play an important role in personal well-being. Chronic stress can have a serious long-term impact on our physical as well as our psychological health, due to ongoing increased levels of the chemicals released in the ‘fight or flight’ response. The currently available stress assessment methods are usually not suitable for daily chronic stress measurement. The paper presents a context-aware chronic stress recognition system that addresses this problem. The proposed system obtains contextual data from various mobile sensors and other external sources in order to calculate the impact of ongoing stress. By identifying and visualizing ongoing stress situations of an individual user, he/she is able to modify his/her behavior in order to successfully avoid them. Clinical evaluation of the proposed methodology has been made in parallel by using electrodermal activity sensor. To the best of our knowledge, the system presented herein is the first one that enables recognition of chronic stress situations on the basis of user context.

  13. Improvement of emotional healthcare system with stress detection from ECG signal.

    Science.gov (United States)

    Tivatansakul, S; Ohkura, M

    2015-01-01

    Our emotional healthcare system is designed to cope with users' negative emotions in daily life. To make the system more intelligent, we integrated emotion recognition by facial expression to provide appropriate services based on user's current emotional state. Our emotion recognition by facial expression has confusion issue to recognize some positive, neutral and negative emotions that make the emotional healthcare system provide a relaxation service even though users don't have negative emotions. Therefore, to increase the effectiveness of the system to provide the relaxation service, we integrate stress detection from ECG signal. The stress detection might be able to address the confusion issue of emotion recognition by facial expression to provide the service. Indeed, our results show that integration of stress detection increases the effectiveness and efficiency of the emotional healthcare system to provide services.

  14. A multimodal image sensor system for identifying water stress in grapevines

    Science.gov (United States)

    Zhao, Yong; Zhang, Qin; Li, Minzan; Shao, Yongni; Zhou, Jianfeng; Sun, Hong

    2012-11-01

    Water stress is one of the most common limitations of fruit growth. Water is the most limiting resource for crop growth. In grapevines, as well as in other fruit crops, fruit quality benefits from a certain level of water deficit which facilitates to balance vegetative and reproductive growth and the flow of carbohydrates to reproductive structures. A multi-modal sensor system was designed to measure the reflectance signature of grape plant surfaces and identify different water stress levels in this paper. The multi-modal sensor system was equipped with one 3CCD camera (three channels in R, G, and IR). The multi-modal sensor can capture and analyze grape canopy from its reflectance features, and identify the different water stress levels. This research aims at solving the aforementioned problems. The core technology of this multi-modal sensor system could further be used as a decision support system that combines multi-modal sensory data to improve plant stress detection and identify the causes of stress. The images were taken by multi-modal sensor which could output images in spectral bands of near-infrared, green and red channel. Based on the analysis of the acquired images, color features based on color space and reflectance features based on image process method were calculated. The results showed that these parameters had the potential as water stress indicators. More experiments and analysis are needed to validate the conclusion.

  15. An automated x-ray stress measurement system using a microcomputer

    International Nuclear Information System (INIS)

    Kurita, Masanori; Miyagawa, Matsuo; Sato, Fumiyoshi; Sugiharai, Shigeru; Ishii, Masami; Sumiyoshi, Michio.

    1985-01-01

    An automated system for a rapid and precise X-ray stress measurement using a microcomputer has been developed. A block diagram of the system and a flowchart for the stress measurement method are shown. Of the various methods, the one most suitable for the material to be measured can be programmed in this system. The residual stress in a hardened steel having a broad diffraction profile (half-width of 7.2 deg ) could be measured in six minutes with a small standard deviation of 13 MPa by the Gaussian curve method using the sin 2 ψ method. Both the oscillation and the fixed ψ methods, using the Gaussian curve method, allow the X-ray stress measurement of coarse-grained steels; the sin 2 ψ diagram obtained by these methods had a good linearity. The residual stress measurement of an annealed chromium powder gave almost zero stress values, -3.2 to 2.9 MPa depending on the method used, showing a high accuracy of the system. (author)

  16. Positive and problematic support, stress and quality of life in patients with systemic lupus erythematosus.

    Science.gov (United States)

    Mazzoni, Davide; Cicognani, Elvira

    2016-09-01

    Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Previous studies showed that perceived social support has an important role in enhancing patient's quality of life (QOL). However, the precise mechanisms through which social support exerts such an effect are not completely understood. The aim of this paper is to test two alternative models explaining the relationship between social support (positive and problematic) and two dimensions of QOL: Health-Related (HR-QOL) and Non-Health-Related (NHR-QOL). Model A (mediation) hypothesized that positive support would reduce stress while problematic support would increase stress), and that this in turn would reduce QOL. Model B (moderation) hypothesized that the effect of support on QOL would be moderated by the experience of stress in that more stressed individuals would show stronger effects. Three hundred and forty-four Italian patients with SLE completed an online questionnaire. Stress partially mediated the relationship between support and QOL dimensions (either HR-QOL and NHR-QOL) thus supporting Model B. As hypothesized, positive support reduced stress, while problematic support increased stress. These findings help to explain the complex relationship between social support, stress and QOL in patients with SLE.

  17. Activity of the Hypothalamic-Pituitary-Adrenal System in Prenatally Stressed Male Rats on the Experimental Model of Post-Traumatic Stress Disorder.

    Science.gov (United States)

    Pivina, S G; Rakitskaya, V V; Akulova, V K; Ordyan, N E

    2016-03-01

    Using the experimental model of post-traumatic stress disorder (stress-restress paradigm), we studied the dynamics of activity of the hypothalamic-pituitary-adrenal system (HPAS) in adult male rats, whose mothers were daily subjected to restraint stress on days 15-19 of pregnancy. Prenatally stressed males that were subjected to combined stress and subsequent restress exhibited not only increased sensitivity of HPAS to negative feedback signals (manifested under restress conditions), but also enhanced stress system reactivity. These changes persisted to the 30th day after restress. Under basal conditions, the number of cells in the hypothalamic paraventricular nucleus of these animals expressing corticotropin-releasing hormone and vasopressin was shown to decrease progressively on days 1-30. By contrast, combined stress and restress in control animals were followed by an increase in the count of CRH-immunopositive cells in the magnocellular and parvocellular parts of the paraventricular nucleus and number of vasopressin-immunopositive cells in the magnocellular part of the nucleus (to the 10th day after restress). Our results indicate a peculiar level of functional activity of HPAS in prenatally stressed males in the stress-restress paradigm: decreased activity under basal conditions and enhanced reactivity during stress.

  18. Automatic stress-relieving music recommendation system based on photoplethysmography-derived heart rate variability analysis.

    Science.gov (United States)

    Shin, Il-Hyung; Cha, Jaepyeong; Cheon, Gyeong Woo; Lee, Choonghee; Lee, Seung Yup; Yoon, Hyung-Jin; Kim, Hee Chan

    2014-01-01

    This paper presents an automatic stress-relieving music recommendation system (ASMRS) for individual music listeners. The ASMRS uses a portable, wireless photoplethysmography module with a finger-type sensor, and a program that translates heartbeat signals from the sensor to the stress index. The sympathovagal balance index (SVI) was calculated from heart rate variability to assess the user's stress levels while listening to music. Twenty-two healthy volunteers participated in the experiment. The results have shown that the participants' SVI values are highly correlated with their prespecified music preferences. The sensitivity and specificity of the favorable music classification also improved as the number of music repetitions increased to 20 times. Based on the SVI values, the system automatically recommends favorable music lists to relieve stress for individuals.

  19. Phloem small RNAs, nutrient stress responses, and systemic mobility

    Directory of Open Access Journals (Sweden)

    Kehr Julia

    2010-04-01

    Full Text Available Abstract Background Nutrient availabilities and needs have to be tightly coordinated between organs to ensure a balance between uptake and consumption for metabolism, growth, and defense reactions. Since plants often have to grow in environments with sub-optimal nutrient availability, a fine tuning is vital. To achieve this, information has to flow cell-to-cell and over long-distance via xylem and phloem. Recently, specific miRNAs emerged as a new type of regulating molecules during stress and nutrient deficiency responses, and miR399 was suggested to be a phloem-mobile long-distance signal involved in the phosphate starvation response. Results We used miRNA microarrays containing all known plant miRNAs and a set of unknown small (s RNAs earlier cloned from Brassica phloem sap 1, to comprehensively analyze the phloem response to nutrient deficiency by removing sulfate, copper or iron, respectively, from the growth medium. We show that phloem sap contains a specific set of sRNAs that is distinct from leaves and roots, and that the phloem also responds specifically to stress. Upon S and Cu deficiencies phloem sap reacts with an increase of the same miRNAs that were earlier characterized in other tissues, while no clear positive response to -Fe was observed. However, -Fe led to a reduction of Cu- and P-responsive miRNAs. We further demonstrate that under nutrient starvation miR399 and miR395 can be translocated through graft unions from wild type scions to rootstocks of the miRNA processing hen1-1 mutant. In contrast, miR171 was not transported. Translocation of miR395 led to a down-regulation of one of its targets in rootstocks, suggesting that this transport is of functional relevance, and that miR395, in addition to the well characterized miR399, could potentially act as a long-distance information transmitter. Conclusions Phloem sap contains a specific set of sRNAs, of which some specifically accumulate in response to nutrient deprivation. From

  20. Computer-aided stress analysis system for nuclear plant primary components

    International Nuclear Information System (INIS)

    Murai, Tsutomu; Tokumaru, Yoshio; Yamazaki, Junko.

    1980-06-01

    Generally it needs a vast quantity of calculation to make the stress analysis reports of nuclear plant primary components. In Japan, especially, stress analysis reports are under obligation to make for each plant. In Mitsubishi Heavy Industries, Ltd., We have been making great efforts to rationalize the process of analysis for about these ten years. As the result of rationalization up to now, a computer-aided stress analysis system using graphic display, graphic tablet, data file, etc. was accomplished and it needs us only the least hand work. In addition we developed a fracture safety analysis system. And we are going to develop the input generator system for 3-dimensional FEM analysis by graphics terminals in the near future. We expect that when the above-mentioned input generator system is accomplished, it will be possible for us to solve instantly any case of problem. (author)

  1. Balneotherapy, Immune System, and Stress Response: A Hormetic Strategy?

    Directory of Open Access Journals (Sweden)

    Isabel Gálvez

    2018-06-01

    Full Text Available Balneotherapy is a clinically effective complementary approach in the treatment of low-grade inflammation- and stress-related pathologies. The biological mechanisms by which immersion in mineral-medicinal water and the application of mud alleviate symptoms of several pathologies are still not completely understood, but it is known that neuroendocrine and immunological responses—including both humoral and cell-mediated immunity—to balneotherapy are involved in these mechanisms of effectiveness; leading to anti-inflammatory, analgesic, antioxidant, chondroprotective, and anabolic effects together with neuroendocrine-immune regulation in different conditions. Hormesis can play a critical role in all these biological effects and mechanisms of effectiveness. The hormetic effects of balneotherapy can be related to non-specific factors such as heat—which induces the heat shock response, and therefore the synthesis and release of heat shock proteins—and also to specific biochemical components such as hydrogen sulfide (H2S in sulfurous water and radon in radioactive water. Results from several investigations suggest that the beneficial effects of balneotherapy and hydrotherapy are consistent with the concept of hormesis, and thus support a role for hormesis in hydrothermal treatments.

  2. HammerCloud: A Stress Testing System for Distributed Analysis

    International Nuclear Information System (INIS)

    Ster, Daniel C van der; García, Mario Úbeda; Paladin, Massimo; Elmsheuser, Johannes

    2011-01-01

    Distributed analysis of LHC data is an I/O-intensive activity which places large demands on the internal network, storage, and local disks at remote computing facilities. Commissioning and maintaining a site to provide an efficient distributed analysis service is therefore a challenge which can be aided by tools to help evaluate a variety of infrastructure designs and configurations. HammerCloud is one such tool; it is a stress testing service which is used by central operations teams, regional coordinators, and local site admins to (a) submit arbitrary number of analysis jobs to a number of sites, (b) maintain at a steady-state a predefined number of jobs running at the sites under test, (c) produce web-based reports summarizing the efficiency and performance of the sites under test, and (d) present a web-interface for historical test results to both evaluate progress and compare sites. HammerCloud was built around the distributed analysis framework Ganga, exploiting its API for grid job management. HammerCloud has been employed by the ATLAS experiment for continuous testing of many sites worldwide, and also during large scale computing challenges such as STEP'09 and UAT'09, where the scale of the tests exceeded 10,000 concurrently running and 1,000,000 total jobs over multi-day periods. In addition, HammerCloud is being adopted by the CMS experiment; the plugin structure of HammerCloud allows the execution of CMS jobs using their official tool (CRAB).

  3. HammerCloud: A Stress Testing System for Distributed Analysis

    CERN Document Server

    van der Ster, Daniel C; Ubeda Garcia, Mario; Paladin, Massimo

    2011-01-01

    Distributed analysis of LHC data is an I/O-intensive activity which places large demands on the internal network, storage, and local disks at remote computing facilities. Commissioning and maintaining a site to provide an efficient distributed analysis service is therefore a challenge which can be aided by tools to help evaluate a variety of infrastructure designs and configurations. HammerCloud (HC) is one such tool; it is a stress testing service which is used by central operations teams, regional coordinators, and local site admins to (a) submit arbitrary number of analysis jobs to a number of sites, (b) maintain at a steady-state a predefined number of jobs running at the sites under test, (c) produce web-based reports summarizing the efficiency and performance of the sites under test, and (d) present a web-interface for historical test results to both evaluate progress and compare sites. HC was built around the distributed analysis framework Ganga, exploiting its API for grid job management. HC has been ...

  4. The protective role of exercise on stress system dysregulation and comorbidities.

    Science.gov (United States)

    Tsatsoulis, Agathocles; Fountoulakis, Stelios

    2006-11-01

    The human body, when under threat, elicits a set of neuroendocrine responses, including an increased secretion of glucocorticoids (GCs) and catecholamines from the adrenal gland and the activation of the sympathetic nervous system. These hormonal secretions allow a "fight or flight" response by mobilizing endogenous substrate and inducing a state of insulin resistance in the liver and skeletal muscles. Although the stress response was essential in ancient times to survive physical aggression, this threat has disappeared in our industrialized societies. However, in today's environment, the same stress responses can be elicited by emotional stimuli or professional and social stress. Such psychological stress may be protracted and unrelated to an increased metabolic demand. Thus, the energy mobilized is not used but is stored in visceral fat depots by the combined action of hypercortisolism and hyperinsulinemia. In addition, chronic activation of the stress system causes suppression of the gonadal, growth hormone (GH), and thyroid axes. These metabolic disturbances, in concert, lead to the clinical expression of a number of comorbidities including central obesity, hypertension, dyslipidemia, and endothelial dysfunction, all components of the metabolic syndrome and cardiometabolic risk factors. Moreover, chronic stress has deleterious effects on the brain and, in particular, affects hippocampal structure and function leading to cognitive and mood disturbances. Importantly, this stress-induced clinical phenotype is likely to be exaggerated in the presence of physical inactivity, resulting in a "stress-induced/exercise deficient" phenotype. Assuming that the stress response is a neuroendocrine mechanism that occurs in anticipation of physical action, then physical activity should be the natural means to prevent the consequences of stress. Indeed, accumulating evidence documents the beneficial effects of regular exercise in preventing or ameliorating the metabolic and

  5. Multi-Axis Prosthetic Knee Resembles Alpine Skiing Movements of an Intact Leg

    Science.gov (United States)

    Demšar, Ivan; Duhovnik, Jože; Lešnik, Blaž; Supej, Matej

    2015-01-01

    The purpose of the study was to analyse the flexion angles of the ski boot, ankle and knee joints of an above-knee prosthesis and to compare them with an intact leg and a control group of skiers. One subject with an above-knee amputation of the right leg and eight healthy subjects simulated the movement of a skiing turn by performing two-leg squats in laboratory conditions. By adding additional loads in proportion to body weight (BW; +1/3 BW, +2/3 BW, +3/3 BW), various skiing regimes were simulated. Change of Flexion Angle (CoFA) and Range of Motion (RoM) in the ski boot, ankle and knee joints were calculated and compared. An average RoM in the skiing boot on the side of prosthesis (4.4 ± 1.1°) was significantly lower compared to an intact leg (5.9 ± 1.8°) and the control group (6.5 ± 2.3°). In the ankle joint, the average RoM was determined to be 13.2±2.9° in the prosthesis, 12.7 ± 2.8° in an intact leg and 14.8±3.6 in the control group. However, the RoM of the knee joint in the prosthesis (42.2 ± 4.2°) was significantly larger than that of the intact leg (34.7 ± 4.4°). The average RoM of the knee joint in the control group was 47.8 ± 5.4°. The influences of additional loads on the kinematics of the lower extremities were different on the side of the prosthesis and on the intact leg. In contrast, additional loads did not produce any significant differences in the control group. Although different CoFAs in the ski boot, ankle and knee joints were used, an above-knee prosthesis with a built-in multi-axis prosthetic knee enables comparable leg kinematics in simulated alpine skiing. Key points The RoM in the ski boot on the side of the prosthetic leg was smaller than the RoM of the intact leg and the control group of healthy subjects. The RoM in the ankle joint of prosthetic leg was comparable to that of the intact leg and the control group of healthy subjects. The RoM in the prosthetic knee joint was greater than the RoM in the knee joint of the

  6. Multiple Two-Component Systems of Streptococcus mutans Regulate Agmatine Deiminase Gene Expression and Stress Tolerance▿

    OpenAIRE

    Liu, Yaling; Burne, Robert A.

    2009-01-01

    Induction of the agmatine deiminase system (AgDS) of Streptococcus mutans requires agmatine and is optimal at low pH. We show here that the VicRK, ComDE, and CiaRH two-component systems influence AgDS gene expression in response to acidic and thermal stresses.

  7. Issues in the assessment of personality disorder and substance abuse using the Millon Clinical Multiaxial Inventory (MCMI-II).

    Science.gov (United States)

    Flynn, P M; McCann, J T; Fairbank, J A

    1995-05-01

    Substance abuse treatment clients often present other severe mental health problems that affect treatment outcomes. Hence, screening and assessment for psychological distress and personality disorder are an important part of effective treatment, discharge, and aftercare planning. The Millon Clinical Multiaxial Inventory-II (MCMI-II) frequently is used for this purpose. In this paper, several issues of concern to MCMI-II users are addressed. These include the extent to which MCMI-II scales correspond to DSM-III-R disorders; overdiagnosis of disorders using the MCMI-II; accuracy of MCMI-II diagnostic cut-off scores; and the clinical utility of MCMI-II diagnostic algorithms. Approaches to addressing these issues are offered.

  8. Prediction of pilot opinion ratings using an optimal pilot model. [of aircraft handling qualities in multiaxis tasks

    Science.gov (United States)

    Hess, R. A.

    1977-01-01

    A brief review of some of the more pertinent applications of analytical pilot models to the prediction of aircraft handling qualities is undertaken. The relative ease with which multiloop piloting tasks can be modeled via the optimal control formulation makes the use of optimal pilot models particularly attractive for handling qualities research. To this end, a rating hypothesis is introduced which relates the numerical pilot opinion rating assigned to a particular vehicle and task to the numerical value of the index of performance resulting from an optimal pilot modeling procedure as applied to that vehicle and task. This hypothesis is tested using data from piloted simulations and is shown to be reasonable. An example concerning a helicopter landing approach is introduced to outline the predictive capability of the rating hypothesis in multiaxis piloting tasks.

  9. Reliability analysis and optimisation of subsea compression system facing operational covariate stresses

    International Nuclear Information System (INIS)

    Okaro, Ikenna Anthony; Tao, Longbin

    2016-01-01

    This paper proposes an enhanced Weibull-Corrosion Covariate model for reliability assessment of a system facing operational stresses. The newly developed model is applied to a Subsea Gas Compression System planned for offshore West Africa to predict its reliability index. System technical failure was modelled by developing a Weibull failure model incorporating a physically tested corrosion profile as stress in order to quantify the survival rate of the system under additional operational covariates including marine pH, temperature and pressure. Using Reliability Block Diagrams and enhanced Fusell-Vesely formulations, the whole system was systematically decomposed to sub-systems to analyse the criticality of each component and optimise them. Human reliability was addressed using an enhanced barrier weighting method. A rapid degradation curve is obtained on a subsea system relative to the base case subjected to a time-dependent corrosion stress factor. It reveals that subsea system components failed faster than their Mean time to failure specifications from Offshore Reliability Database as a result of cumulative marine stresses exertion. The case study demonstrated that the reliability of a subsea system can be systematically optimised by modelling the system under higher technical and organisational stresses, prioritising the critical sub-systems and making befitting provisions for redundancy and tolerances. - Highlights: • Novel Weibull Corrosion-Covariate model for reliability analysis of subsea assets. • Predict the accelerated degradation profile of a subsea gas compression. • An enhanced optimisation method based on Fusell-Vesely decomposition process. • New optimisation approach for smoothening of over- and under-designed components. • Demonstrated a significant improvement in producing more realistic failure rate.

  10. A systems approach identifies networks and genes linking sleep and stress: implications for neuropsychiatric disorders.

    Science.gov (United States)

    Jiang, Peng; Scarpa, Joseph R; Fitzpatrick, Karrie; Losic, Bojan; Gao, Vance D; Hao, Ke; Summa, Keith C; Yang, He S; Zhang, Bin; Allada, Ravi; Vitaterna, Martha H; Turek, Fred W; Kasarskis, Andrew

    2015-05-05

    Sleep dysfunction and stress susceptibility are comorbid complex traits that often precede and predispose patients to a variety of neuropsychiatric diseases. Here, we demonstrate multilevel organizations of genetic landscape, candidate genes, and molecular networks associated with 328 stress and sleep traits in a chronically stressed population of 338 (C57BL/6J × A/J) F2 mice. We constructed striatal gene co-expression networks, revealing functionally and cell-type-specific gene co-regulations important for stress and sleep. Using a composite ranking system, we identified network modules most relevant for 15 independent phenotypic categories, highlighting a mitochondria/synaptic module that links sleep and stress. The key network regulators of this module are overrepresented with genes implicated in neuropsychiatric diseases. Our work suggests that the interplay among sleep, stress, and neuropathology emerges from genetic influences on gene expression and their collective organization through complex molecular networks, providing a framework for interrogating the mechanisms underlying sleep, stress susceptibility, and related neuropsychiatric disorders. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  11. A novel two-component system involved in secretion stress response in Streptomyces lividans.

    Directory of Open Access Journals (Sweden)

    Sonia Gullón

    Full Text Available BACKGROUND: Misfolded proteins accumulating outside the bacterial cytoplasmic membrane can interfere with the secretory machinery, hence the existence of quality factors to eliminate these misfolded proteins is of capital importance in bacteria that are efficient producers of secretory proteins. These bacteria normally use a specific two-component system to respond to the stress produced by the accumulation of the misfolded proteins, by activating the expression of HtrA-like proteases to specifically eliminate the incorrectly folded proteins. METHODOLOGY/PRINCIPAL FINDINGS: Overproduction of alpha-amylase in S. lividans causing secretion stress permitted the identification of a two-component system (SCO4156-SCO4155 that regulates three HtrA-like proteases which appear to be involved in secretion stress response. Mutants in each of the genes forming part of the two-genes operon that encodes the sensor and regulator protein components accumulated misfolded proteins outside the cell, strongly suggesting the involvement of this two-component system in the S. lividans secretion stress response. CONCLUSIONS/SIGNIFICANCE: To our knowledge this is the first time that a specific secretion stress response two-component system is found to control the expression of three HtrA-like protease genes in S. lividans, a bacterium that has been repeatedly used as a host for the synthesis of homologous and heterologous secretory proteins of industrial application.

  12. Understanding Water-Stress Responses in Soybean Using Hydroponics System—A Systems Biology Perspective

    Science.gov (United States)

    Tripathi, Prateek; Rabara, Roel C.; Shulaev, Vladimir; Shen, Qingxi J.; Rushton, Paul J.

    2015-01-01

    The deleterious changes in environmental conditions such as water stress bring physiological and biochemical changes in plants, which results in crop loss. Thus, combating water stress is important for crop improvement to manage the needs of growing population. Utilization of hydroponics system in growing plants is questionable to some researchers, as it does not represent an actual field condition. However, trying to address a complex problem like water stress we have to utilize a simpler growing condition like the hydroponics system wherein every input given to the plants can be controlled. With the advent of high-throughput technologies, it is still challenging to address all levels of the genetic machinery whether a gene, protein, metabolite, and promoter. Thus, using a system of reduced complexity like hydroponics can certainly direct us toward the right candidates, if not completely help us to resolve the issue. PMID:26734044

  13. Stress-associated synchronization and desynchronization in geologic and biologic systems

    Science.gov (United States)

    Kluchevsky, A. V.; Kluchevskaya, A. A.

    2010-12-01

    Variations in the annual numbers of representative earthquakes in three areas and six districts of the Baikal rift zone in 1964-2002 were subjected to correlation analysis. Episodes of significant correlations of shock flow rates were found against the background of chaotic seismic activity. They followed the rearrangements (catastrophes) of stresses in the lithosphere, which are also stressing factors for the whole rift geodynamic system. The episode of the late 1970s-early 1980s was particularly long and showed the maximum correlation. Therefore, it can be considered the principal event in seismic process synchronization in the Baikal Rift Zone. The same approach to data analysis revealed similar synchronization and desynchronization phenomena in the behavior of Baikalian turbellaria when they deviated from homeostasis as a result of illumination, which is a stress for this biologic system. Possible reasons for the behavior of biologic and geodynamic systems are discussed in terms of the synergetic concept of phenomena in living and nonliving nature.

  14. Development of fiber-delivered laser peening system to prevent stress corrosion cracking of reactor components

    International Nuclear Information System (INIS)

    Sano, Y.; Kimura, M.; Yoda, M.; Mukai, N.; Sato, K.; Uehara, T.; Ito, T.; Shimamura, M.; Sudo, A.; Suezono, N.

    2001-01-01

    The authors have developed a system to deliver water-penetrable intense laser pulses of frequency-doubled Nd:YAG laser through optical fiber. The system is capable of improving a residual stress on water immersed metal material remotely, which is effective to prevent the initiation of stress corrosion cracking (SCC) of reactor components. Experimental results showed that a compressive residual stress with enough amplitude and depth was built in the surface layer of type 304 stainless steel (SUS304) by irradiating laser pulses through optical fiber with diameter of 1 mm. A prototype peening head with miniaturized dimensions of 88 mm x 46 mm x 25 mm was assembled to con-firm the accessibility to the heat affected zone (HAZ) along weld lines of a reactor core shroud. The accessibility was significantly improved owing to the flexible optical fiber and the miniaturized peening head. The fiber delivered system opens up the possibility of new applications of laser peening. (author)

  15. Operational Modal Analysis based Stress Estimation in Friction Systems

    DEFF Research Database (Denmark)

    Tarpø, Marius; Friis, Tobias; Nabuco, Bruna

    this assumption. In this paper, the precision of estimating the strain response of a nonlinear system is investigated using the operational response of numerical simulations. Local nonlinearities are introduced by adding friction to the test specimen and this paper finds that this approach of strain estimation...

  16. Piping systems, containment pre-stressing and steel ventilation chimney

    International Nuclear Information System (INIS)

    Stuessi, U.

    1996-01-01

    Units 5 and 6 of NPP Kozloduy have been designed initially for seismic levels which are considered too low today. In the frame of an IAEA Coordinated Research Programme, a Swiss team has been commissioned by Natsionalna Elektricheska Kompania, Sofia, to analyse the relevant piping system, the containment prestressing and the steel ventilation chimney and to recommend upgrade measures for adequate seismic capacity where applicable. Seismic input had been specified by and agreed upon earlier by IAEA experts. The necessary investigations have been performed in 1995 and discussed with internationally recognized experts. The main results may be summarized as follows: Upgrades are necessary at different piping sy ports (additional snubbers or viscous dampers). These fixes can be done easily at low cost. The containment prestressing tendons are adequately designed for the specified load combinations. However, unfavourable construction features endanger the reliability. It is therefore strongly recommended to replace the tendons stepwise and to upgrade the existing monitoring system. Finally, the steel ventilation chimney may not withstand a seismic event, however the containment and diesel generator building will not be destroyed at possible impact by the chimney. On the other hand the roof of the main building has to be reinforced partially. It is recommended to continue the project for 1996 and 1997 to implement the upgrade measures mentioned above, to analyse the remaining piping systems and to consolidate all results obtained by different research groups of the IAEA programme with respect to piping systems including components and tanks

  17. Induced Systemic Tolerance to Multiple Stresses Including Biotic and Abiotic Factors by Rhizobacteria

    Directory of Open Access Journals (Sweden)

    Sung-Je Yoo

    2017-06-01

    Full Text Available Recently, global warming and drastic climate change are the greatest threat to the world. The climate change can affect plant productivity by reducing plant adaptation to diverse environments including frequent high temperature; worsen drought condition and increased pathogen transmission and infection. Plants have to survive in this condition with a variety of biotic (pathogen/pest attack and abiotic stress (salt, high/low temperature, drought. Plants can interact with beneficial microbes including plant growth-promoting rhizobacteria, which help plant mitigate biotic and abiotic stress. This overview presents that rhizobacteria plays an important role in induced systemic resistance (ISR to biotic stress or induced systemic tolerance (IST to abiotic stress condition; bacterial determinants related to ISR and/or IST. In addition, we describe effects of rhizobacteria on defense/tolerance related signal pathway in plants. We also review recent information including plant resistance or tolerance against multiple stresses (bioticabiotic. We desire that this review contribute to expand understanding and knowledge on the microbial application in a constantly varying agroecosystem, and suggest beneficial microbes as one of alternative environment-friendly application to alleviate multiple stresses.

  18. Matrix metalloproteinase 9 polymorphisms and systemic lupus erythematosus: correlation with systemic inflammatory markers and oxidative stress.

    Science.gov (United States)

    Bahrehmand, F; Vaisi-Raygani, A; Kiani, A; Rahimi, Z; Tavilani, H; Ardalan, M; Vaisi-Raygani, H; Shakiba, E; Pourmotabbed, T

    2015-05-01

    Systemic lupus erythematosus (SLE) is an autoimmune disease that involves multiple organs and is characterized by persistent systemic inflammation. Among the effects of inflammatory mediators, the induction of matrix metalloproteinases-2 and -9 (MMP-2 and MMP-9) and oxidative stress has been demonstrated to be important in the development of SLE. In this study, the possible association between MMP-9 and MMP-2 functional promoter polymorphism, stress, and inflammatory markers with development of severe cardiovascular disease (CVD), high blood pressure (HBP), and lupus nephropathy (LN) in SLE patients was investigated. The present case-control study consisted of 109 SLE patients with and without CVD, HBP and LN and 101 gender- and age-matched unrelated healthy controls from a population in western Iran. MMP-2 -G1575A and MMP-9 -C1562T polymorphisms were detected by PCR-RFLP, serum MMP-2 and MMP-9, neopterin, malondialdehyde (MDA) and lipid levels were determined by ELISA, HPLC and enzyme assay, respectively. We found that MMP-9 -C1562 T and MMP-2 -G1575A alleles act synergistically to increase the risk of SLE by 2.98 times (p = 0.015). Findings of this study also demonstrated that there is a significant increase in the serum levels of MMP-2, neopterin and MDA and a significant decrease in serum level of MMP-9 in the presence of MMP-9-C1562 T and MMP-2 -G1575A alleles in SLE patients compared to controls. Further, SLE patients with MMP-9 (C/T + T/T) genotype had significantly higher serum concentrations of MMP-2, neopterin, MDA and LDL-C, but lower serum MMP-9 and HDL-C levels than corresponding members of the control group. MMP-9 (C/T + T/T) genotype increased risk of hypertension in SLE patients 2.71-fold. This study for the first time not only suggests that MMP-9 -C1562 T and MMP-2 -G1575A alleles synergistically increase the risk of SLE but also high serum levels of MDA, neopterin, and circulatory levels of MMP-2 and lower MMP-9 in SLE patients. This

  19. Numerical measures of the degree of non-proportionality of multiaxial fatigue loadings

    Directory of Open Access Journals (Sweden)

    A. Bolchoun

    2015-07-01

    Full Text Available The influence of the non-proportional loadings on the fatigue life depends on the material ductility. Ductile materials react with a shortening of lifetime compared to proportional loading conditions. For a semiductile material there is almost no difference between proportional and non-proportional loadings with respect to the fatigue life. Brittle materials show an increase of the lifetime under non-proportional loadings. If fatigue life assessment is performed using stress-based hypotheses, it is a rather difficult task to take into account material ductility correctly, especially the fatigue life reduction as displayed by ductile materials. Most stress-based hypotheses will compute a longer fatigue life under non-proportional loading conditions. There are also hypotheses, which already include quantitative evaluation of the non-proportionality (e.g. EESH, SSCH and MWCM. Anyway in order to improve assessment for ductile materials, some sort of numerical measure for the degree of non-proportionality of the fatigue loading is required. A number of measures of this kind (or non-proportionality factors were proposed in the literature and are discussed here: - the factor used in EESH is a quotient of stress amplitudes integrals, - the factor according to Gaier, which works with a discrete stress tensor values in a scaled stress space, - the factor according to Kanazawa, which makes use of plane-based stress values, - the factor used in MWCM, which exploits stress values in the plane with the highest shear stress amplitude, a new non-proportionality factor, which is based on the correlation between individual stress tensor components, is proposed. General requirements imposed on the non-proportionality factors are discussed and each of the factors is evaluated with respect to these requirements. Also application with the stress-based hypotheses is discussed and illustrated using the experimental data for aluminum and magnesium welded joints under

  20. 4D stress evolution models of the San Andreas Fault System: Investigating time- and depth-dependent stress thresholds over multiple earthquake cycles

    Science.gov (United States)

    Burkhard, L. M.; Smith-Konter, B. R.

    2017-12-01

    4D simulations of stress evolution provide a rare insight into earthquake cycle crustal stress variations at seismogenic depths where earthquake ruptures nucleate. Paleoseismic estimates of earthquake offset and chronology, spanning multiple earthquakes cycles, are available for many well-studied segments of the San Andreas Fault System (SAFS). Here we construct new 4D earthquake cycle time-series simulations to further study the temporally and spatially varying stress threshold conditions of the SAFS throughout the paleoseismic record. Interseismic strain accumulation, co-seismic stress drop, and postseismic viscoelastic relaxation processes are evaluated as a function of variable slip and locking depths along 42 major fault segments. Paleoseismic earthquake rupture histories provide a slip chronology dating back over 1000 years. Using GAGE Facility GPS and new Sentinel-1A InSAR data, we tune model locking depths and slip rates to compute the 4D stress accumulation within the seismogenic crust. Revised estimates of stress accumulation rate are most significant along the Imperial (2.8 MPa/100yr) and Coachella (1.2 MPa/100yr) faults, with a maximum change in stress rate along some segments of 11-17% in comparison with our previous estimates. Revised estimates of earthquake cycle stress accumulation are most significant along the Imperial (2.25 MPa), Coachella (2.9 MPa), and Carrizo (3.2 MPa) segments, with a 15-29% decrease in stress due to locking depth and slip rate updates, and also postseismic relaxation from the El Mayor-Cucapah earthquake. Because stress drops of major strike-slip earthquakes rarely exceed 10 MPa, these models may provide a lower bound on estimates of stress evolution throughout the historical era, and perhaps an upper bound on the expected recurrence interval of a particular fault segment. Furthermore, time-series stress models reveal temporally varying stress concentrations at 5-10 km depths, due to the interaction of neighboring fault

  1. Role of Cortistatin in the Stressed Immune System.

    Science.gov (United States)

    Delgado, Mario; Gonzalez-Rey, Elena

    2017-01-01

    The immune system is faced with the daunting job of defending the organism against invading pathogens, while at the same time preserving the body integrity and maintaining tolerance to its own tissues. Loss of self-tolerance compromises immune homeostasis and leads to the onset of autoimmune disorders. The identification of endogenous factors that control immune tolerance and inflammation is a key goal for immunologists. Evidences from the last decade indicate that the neuropeptide cortistatin is one of the endogenous factors. Cortistatin is produced by immune cells and through its binding to various receptors, it exerts potent anti-inflammatory actions and participates in the maintenance of immune tolerance at multiple levels, especially in immunological disorders. Cortistatin emerges as a key element in the bidirectional communication between the neuroendocrine and immune systems aimed at regulating body homeostasis. © 2017 S. Karger AG, Basel.

  2. Tactical decision making under stress (TADMUS) decision support system

    OpenAIRE

    Morrison, Jeffrey G.; Kelly, Richard T.; Moore, Ronald A.; Hutchins, Susan G.

    1996-01-01

    A prototype decision support system (DSS) was developed to enhance Navy tactical decision making based on naturalistic decision processes. Displays were developed to support critical decision making tasks through recognition-primed and explanation-based reasoning processes and cognitive analysis of the decision making problems faced by Navy tactical officers in a shipboard Combat Information Center. Baseline testing in high intensity, peace keeping, littoral scenarios indicated...

  3. Stress and Welfare of African Catfish (Clarias gariepinus Burchell, 1822) in a Coupled Aquaponic System

    OpenAIRE

    Björn Baßmann; Matthias Brenner; Harry W. Palm

    2017-01-01

    African catfish (Clarias gariepinus) were investigated for physiological stress parameters to assess the influence of different cultivation techniques on fish welfare. The fish were reared in two conceptually identical recirculating aquaculture systems (RAS) constructed in a greenhouse. One system was combined with a floating raft hydroponic unit to culture cucumbers (Cucumis sativus) only using the process water. The second system remained without the plant cultivation unit and functioned as...

  4. Shearographic System for Dynamic Analysis of Materials under Heat Stress

    Directory of Open Access Journals (Sweden)

    Nelson A. Correa-Rojas

    2013-11-01

    Full Text Available Shearography is a tool for monitoring and inspecting of structural flaws and imperfections in different types of industrial, automotive and aeronautics applications. It is based on digital correlation of two speckle patterns in two states of interest: with and without load. The technique has the special quality of being very robust against environmental disturbances. We present a shearographic system to analyze the dynamic behavior of the strain that suffers a material in response to changes in temperature throughout the thermal load process.

  5. Sex differences in the locus coeruleus-norepinephrine system and its regulation by stress.

    Science.gov (United States)

    Bangasser, Debra A; Wiersielis, Kimberly R; Khantsis, Sabina

    2016-06-15

    Women are more likely than men to suffer from post-traumatic stress disorder (PTSD) and major depression. In addition to their sex bias, these disorders share stress as an etiological factor and hyperarousal as a symptom. Thus, sex differences in brain arousal systems and their regulation by stress could help explain increased vulnerability to these disorders in women. Here we review preclinical studies that have identified sex differences in the locus coeruleus (LC)-norepinephrine (NE) arousal system. First, we detail how structural sex differences in the LC can bias females towards increased arousal in response to emotional events. Second, we highlight studies demonstrating that estrogen can increase NE in LC target regions by enhancing the capacity for NE synthesis, while reducing NE degradation, potentially increasing arousal in females. Third, we review data revealing how sex differences in the stress receptor, corticotropin releasing factor 1 (CRF1), can increase LC neuronal sensitivity to CRF in females compared to males. This effect could translate into hyperarousal in women under conditions of CRF hypersecretion that occur in PTSD and depression. The implications of these sex differences for the treatment of stress-related psychiatric disorders are discussed. Moreover, the value of using information regarding biological sex differences to aid in the development of novel pharmacotherapies to better treat men and women with PTSD and depression is also highlighted. This article is part of a Special Issue entitled SI: Noradrenergic System. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Review of family relational stress and pediatric asthma: the value of biopsychosocial systemic models.

    Science.gov (United States)

    Wood, Beatrice L; Miller, Bruce D; Lehman, Heather K

    2015-06-01

    Asthma is the most common chronic disease in children. Despite dramatic advances in pharmacological treatments, asthma remains a leading public health problem, especially in socially disadvantaged minority populations. Some experts believe that this health gap is due to the failure to address the impact of stress on the disease. Asthma is a complex disease that is influenced by multilevel factors, but the nature of these factors and their interrelations are not well understood. This paper aims to integrate social, psychological, and biological literatures on relations between family/parental stress and pediatric asthma, and to illustrate the utility of multilevel systemic models for guiding treatment and stimulating future research. We used electronic database searches and conducted an integrated analysis of selected epidemiological, longitudinal, and empirical studies. Evidence is substantial for the effects of family/parental stress on asthma mediated by both disease management and psychobiological stress pathways. However, integrative models containing specific pathways are scarce. We present two multilevel models, with supporting data, as potential prototypes for other such models. We conclude that these multilevel systems models may be of substantial heuristic value in organizing investigations of, and clinical approaches to, the complex social-biological aspects of family stress in pediatric asthma. However, additional systemic models are needed, and the models presented herein could serve as prototypes for model development. © 2015 Family Process Institute.

  7. Rapid stress system drives chemical transfer of fear from sender to receiver.

    Directory of Open Access Journals (Sweden)

    Jasper H B de Groot

    Full Text Available Humans can register another person's fear not only with their eyes and ears, but also with their nose. Previous research has demonstrated that exposure to body odors from fearful individuals elicited implicit fear in others. The odor of fearful individuals appears to have a distinctive signature that can be produced relatively rapidly, driven by a physiological mechanism that has remained unexplored in earlier research. The apocrine sweat glands in the armpit that are responsible for chemosignal production contain receptors for adrenalin. We therefore expected that the release of adrenalin through activation of the rapid stress response system (i.e., the sympathetic-adrenal medullary system is what drives the release of fear sweat, as opposed to activation of the slower stress response system (i.e., hypothalamus-pituitary-adrenal axis. To test this assumption, sweat was sampled while eight participants prepared for a speech. Participants had higher heart rates and produced more armpit sweat in the fast stress condition, compared to baseline and the slow stress condition. Importantly, exposure to sweat from participants in the fast stress condition induced in receivers (N = 31 a simulacrum of the state of the sender, evidenced by the emergence of a fearful facial expression (facial electromyography and vigilant behavior (i.e., faster classification of emotional facial expressions.

  8. Stress analysis in a pedicle screw fixation system with flexible rods in the lumbar spine.

    Science.gov (United States)

    Kim, Kyungsoo; Park, Won Man; Kim, Yoon Hyuk; Lee, SuKyoung

    2010-01-01

    Breakage of screws has been one of the most common complications in spinal fixation systems. However, no studies have examined the breakage risk of pedicle screw fixation systems that use flexible rods, even though flexible rods are currently being used for dynamic stabilization. In this study, the risk of breakage of screws for the rods with various flexibilities in pedicle screw fixation systems is investigated by calculating the von Mises stress as a breakage risk factor using finite element analysis. Three-dimensional finite element models of the lumbar spine with posterior one-level spinal fixations at L4-L5 using four types of rod (a straight rod, a 4 mm spring rod, a 3 mm spring rod, and a 2 mm spring rod) were developed. The von Mises stresses in both the pedicle screws and the rods were analysed under flexion, extension, lateral bending, and torsion moments of 10 Nm with a follower load of 400 N. The maximum von Mises stress, which was concentrated on the neck region of the pedicle screw, decreased as the flexibility of the rod increased. However, the ratio of the maximum stress in the rod to the yield stress increased substantially when a highly flexible rod was used. Thus, the level of rod flexibility should be considered carefully when using flexible rods for dynamic stabilization because the intersegmental motion facilitated by the flexible rod results in rod breakage.

  9. Aggression, Social Stress, and the Immune System in Humans and Animal Models

    Directory of Open Access Journals (Sweden)

    Aki Takahashi

    2018-03-01

    Full Text Available Social stress can lead to the development of psychological problems ranging from exaggerated anxiety and depression to antisocial and violence-related behaviors. Increasing evidence suggests that the immune system is involved in responses to social stress in adulthood. For example, human studies show that individuals with high aggression traits display heightened inflammatory cytokine levels and dysregulated immune responses such as slower wound healing. Similar findings have been observed in patients with depression, and comorbidity of depression and aggression was correlated with stronger immune dysregulation. Therefore, dysregulation of the immune system may be one of the mediators of social stress that produces aggression and/or depression. Similar to humans, aggressive animals also show increased levels of several proinflammatory cytokines, however, unlike humans these animals are more protected from infectious organisms and have faster wound healing than animals with low aggression. On the other hand, subordinate animals that receive repeated social defeat stress have been shown to develop escalated and dysregulated immune responses such as glucocorticoid insensitivity in monocytes. In this review we synthesize the current evidence in humans, non-human primates, and rodents to show a role for the immune system in responses to social stress leading to psychiatric problems such as aggression or depression. We argue that while depression and aggression represent two fundamentally different behavioral and physiological responses to social stress, it is possible that some overlapped, as well as distinct, pattern of immune signaling may underlie both of them. We also argue the necessity of studying animal models of maladaptive aggression induced by social stress (i.e., social isolation for understanding neuro-immune mechanism of aggression, which may be relevant to human aggression.

  10. Aggression, Social Stress, and the Immune System in Humans and Animal Models.

    Science.gov (United States)

    Takahashi, Aki; Flanigan, Meghan E; McEwen, Bruce S; Russo, Scott J

    2018-01-01

    Social stress can lead to the development of psychological problems ranging from exaggerated anxiety and depression to antisocial and violence-related behaviors. Increasing evidence suggests that the immune system is involved in responses to social stress in adulthood. For example, human studies show that individuals with high aggression traits display heightened inflammatory cytokine levels and dysregulated immune responses such as slower wound healing. Similar findings have been observed in patients with depression, and comorbidity of depression and aggression was correlated with stronger immune dysregulation. Therefore, dysregulation of the immune system may be one of the mediators of social stress that produces aggression and/or depression. Similar to humans, aggressive animals also show increased levels of several proinflammatory cytokines, however, unlike humans these animals are more protected from infectious organisms and have faster wound healing than animals with low aggression. On the other hand, subordinate animals that receive repeated social defeat stress have been shown to develop escalated and dysregulated immune responses such as glucocorticoid insensitivity in monocytes. In this review we synthesize the current evidence in humans, non-human primates, and rodents to show a role for the immune system in responses to social stress leading to psychiatric problems such as aggression or depression. We argue that while depression and aggression represent two fundamentally different behavioral and physiological responses to social stress, it is possible that some overlapped, as well as distinct, pattern of immune signaling may underlie both of them. We also argue the necessity of studying animal models of maladaptive aggression induced by social stress (i.e., social isolation) for understanding neuro-immune mechanism of aggression, which may be relevant to human aggression.

  11. Statins and oxidative stress in the cardiovascular system.

    Science.gov (United States)

    Margaritis, Marios; Sanna, Fabio; Antoniades, Charalambos

    2017-09-26

    Statins are widely established as an important class of medications for primary and secondary prevention of cardiovascular disease. In addition to their lipid-lowering effects, mounting evidence suggests that statins exhibit non-lipid-lowering mediated effects in the cardiovascular system. These so called "pleiotropic" effects are partly due to antioxidant properties of statins. These are mediated by inhibition of the mevalonate pathway, which interferes with small GTP-ase protein prenylation. This, in turn, leads to anti-oxidant effects of statins via a plethora of mechanisms. Statins prevent the activation of the pro-oxidant enzyme NADPH-oxidase by interfering with Rac1 activation and translocation to the membrane, as well as reducing expression of crucial subunits of NADPH-oxidase. Statins also enhance the expression, enzymatic activity and coupling of endothelial nitric oxide synthase (eNOS), through mevalonate-dependent effects. The net result is a restoration of the redox balance in the cardiovascular system, with subsequent anti-atherosclerotic and cardioprotective effects. While the evidence from basic science studies and animal models is strong, more clinical trials are required to establish the relevance of these pleiotropic effects to human cardiovascular disease and potentially lead to expanded indications for statin treatment or alternative therapeutic strategies. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  12. Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: Relevance for sex differences in stress-related disorders.

    Science.gov (United States)

    Shepard, Ryan; Page, Chloe E; Coutellier, Laurence

    2016-09-22

    Stress-induced modifications of the prefrontal cortex (PFC) are believed to contribute to the onset of mood disorders, such as depression and anxiety, which are more prevalent in women. In depression, the PFC is hypoactive; however the origin of this hypoactivity remains unclear. Possibly, stress could impact the prefrontal GABAergic inhibitory system that, as a result, impairs the functioning of downstream limbic structures controlling emotions. Preclinical evidence indicates that the female PFC is more sensitive to the effects of stress. These findings suggest that exposure to stress could lead to sex-specific alterations in prefrontal GABAergic signaling, which contribute to sex-specific abnormal functioning of limbic regions. These limbic changes could promote the onset of depressive and anxiety behaviors in a sex-specific manner, providing a possible mechanism mediating sex differences in the clinical presentation of stress-related mood disorders. We addressed this hypothesis using a mouse model of stress-induced depressive-like behaviors: the unpredictable chronic mild stress (UCMS) paradigm. We observed changes in prefrontal GABAergic signaling after exposure to UCMS most predominantly in females. Increased parvalbumin (PV) expression and decreased prefrontal neuronal activity were correlated in females with severe emotionality deficit following UCMS, and with altered activity of the amygdala. In males, small changes in emotionality following UCMS were associated with minor changes in prefrontal PV expression, and with hypoactivity of the nucleus accumbens. Our data suggest that prefrontal hypoactivity observed in stress-related mood disorders could result from stress-induced increases in PV expression, particularly in females. This increased vulnerability of the female prefrontal PV system to stress could underlie sex differences in the prevalence and symptomatology of stress-related mood disorders. Copyright © 2016 IBRO. Published by Elsevier Ltd. All

  13. From scientific instrument to industrial machine coping with architectural stress in embedded systems

    CERN Document Server

    Doornbos, Richard

    2012-01-01

    Architectural stress is the inability of a system design to respond to new market demands. It is an important yet often concealed issue in high tech systems. In From scientific instrument to industrial machine, we look at the phenomenon of architectural stress in embedded systems in the context of a transmission electron microscope system built by FEI Company. Traditionally, transmission electron microscopes are manually operated scientific instruments, but they also have enormous potential for use in industrial applications. However, this new market has quite different characteristics. There are strong demands for cost-effective analysis, accurate and precise measurements, and ease-of-use. These demands can be translated into new system qualities, e.g. reliability, predictability and high throughput, as well as new functions, e.g. automation of electron microscopic analyses, automated focusing and positioning functions. From scientific instrument to industrial machine takes a pragmatic approach to the proble...

  14. Predictive maintenance policy for a gradually deteriorating system subject to stress

    Energy Technology Data Exchange (ETDEWEB)

    Deloux, E. [IRCCyN/Ecole des Mines de Nantes, Nantes (France); Castanier, B. [IRCCyN/Ecole des Mines de Nantes, Nantes (France)], E-mail: bruno.castanier@emn.fr; Berenguer, C. [Universite de Technologie de Troyes/CNRS, Troyes (France)

    2009-02-15

    This paper deals with a predictive maintenance policy for a continuously deteriorating system subject to stress. We consider a system with two failure mechanisms which are, respectively, due to an excessive deterioration level and a shock. To optimize the maintenance policy of the system, an approach combining statistical process control (SPC) and condition-based maintenance (CBM) is proposed. CBM policy is used to inspect and replace the system according to the observed deterioration level. SPC is used to monitor the stress covariate. In order to assess the performance of the proposed maintenance policy and to minimize the long-run expected maintenance cost per unit of time, a mathematical model for the maintained system cost is derived. Analysis based on numerical results are conducted to highlight the properties of the proposed maintenance policy in respect to the different maintenance parameters.

  15. Predictive maintenance policy for a gradually deteriorating system subject to stress

    International Nuclear Information System (INIS)

    Deloux, E.; Castanier, B.; Berenguer, C.

    2009-01-01

    This paper deals with a predictive maintenance policy for a continuously deteriorating system subject to stress. We consider a system with two failure mechanisms which are, respectively, due to an excessive deterioration level and a shock. To optimize the maintenance policy of the system, an approach combining statistical process control (SPC) and condition-based maintenance (CBM) is proposed. CBM policy is used to inspect and replace the system according to the observed deterioration level. SPC is used to monitor the stress covariate. In order to assess the performance of the proposed maintenance policy and to minimize the long-run expected maintenance cost per unit of time, a mathematical model for the maintained system cost is derived. Analysis based on numerical results are conducted to highlight the properties of the proposed maintenance policy in respect to the different maintenance parameters

  16. Renal Oxidative Stress Induced by Long-Term Hyperuricemia Alters Mitochondrial Function and Maintains Systemic Hypertension

    Directory of Open Access Journals (Sweden)

    Magdalena Cristóbal-García

    2015-01-01

    Full Text Available We addressed if oxidative stress in the renal cortex plays a role in the induction of hypertension and mitochondrial alterations in hyperuricemia. A second objective was to evaluate whether the long-term treatment with the antioxidant Tempol prevents renal oxidative stress, mitochondrial alterations, and systemic hypertension in this model. Long-term (11-12 weeks and short-term (3 weeks effects of oxonic acid induced hyperuricemia were studied in rats (OA, 750 mg/kg BW, OA+Allopurinol (AP, 150 mg/L drinking water, OA+Tempol (T, 15 mg/kg BW, or vehicle. Systolic blood pressure, renal blood flow, and vascular resistance were measured. Tubular damage (urine N-acetyl-β-D-glucosaminidase and oxidative stress markers (lipid and protein oxidation along with ATP levels were determined in kidney tissue. Oxygen consumption, aconitase activity, and uric acid were evaluated in isolated mitochondria from renal cortex. Short-term hyperuricemia resulted in hypertension without demonstrable renal oxidative stress or mitochondrial dysfunction. Long-term hyperuricemia induced hypertension, renal vasoconstriction, tubular damage, renal cortex oxidative stress, and mitochondrial dysfunction and decreased ATP levels. Treatments with Tempol and allopurinol prevented these alterations. Renal oxidative stress induced by hyperuricemia promoted mitochondrial functional disturbances and decreased ATP content, which represent an additional pathogenic mechanism induced by chronic hyperuricemia. Hyperuricemia-related hypertension occurs before these changes are evident.

  17. Brassinosteroids Denigrate the Seasonal Stress through Antioxidant Defense System in Seedlings of Brassica juncea L.

    Directory of Open Access Journals (Sweden)

    Sandeep Kumar

    2014-05-01

    Full Text Available The present work has been undertaken to study the effect of exogenously application of 24-epiBL and 28-homoBL on soluble protein, proline contents and antioxidant defense system of Brassica juncea L. RLM 619 under the influence of seasonal stress. It was observed that 24-epiBL and 28-homoBL treatment enhance the soluble protein, dry weight and shoot length of B. juncea seedlings under seasonal stress. If seeds treated with the different concentrations (10-6, 10-8 and 10-10 M of 24-epiBL and 28-homoBL revealed batter growth, protein and proline contents as compare to untreated seedlings. Similarly the activities of antioxidant enzymes SOD, CAT, APOX, DHAR, PPO and Auxinases were enhanced by the application of different concentration of both brassinosteroids, whereas MDA content was decrease with both brassinosteroids treatments. Then we have concluded that both brassinolides have the seasonal stress ameliorative properties in B. juncea seedlings grown under the influence of seasonal stress. This study culminates to the role of brassinolides as an anti-stress property for protection of plant from various types of stresses.

  18. The psychometric properties of the Perceived Stress Scale-10 among patients with systemic lupus erythematosus.

    Science.gov (United States)

    Mills, S D; Azizoddin, D; Racaza, G Z; Wallace, D J; Weisman, M H; Nicassio, P M

    2017-10-01

    Objective Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease characterized by periods of remission and recurrent flares, which have been associated with stress. Despite the significance of stress in this disease, the Perceived Stress Scale-10 has yet to be psychometrically evaluated in patients with SLE. Methods Exploratory factor analysis was used to examine the structural validity of the Perceived Stress Scale-10 among patients with SLE ( N = 138) receiving medical care at Cedars Sinai Medical Center. Cronbach's coefficient alpha was used to examine internal consistency reliability, and Pearson product-moment correlations were used to examine convergent validity with measures of anxiety, depression, helplessness, and disease activity. Results Exploratory factor analysis provided support for a two-factor structure (comparative fit index = .95; standardized root mean residual = .04; root mean square error of approximation = .08). Internal consistency reliability was good for both factors (α = .84 and .86). Convergent validity was evidenced via significant correlations with measures of anxiety, depression, and helplessness. There were no significant correlations with the measure of disease activity. Conclusion The Perceived Stress Scale-10 can be used to examine perceived stress among patients with SLE.

  19. Heat stress mortality and desired adaptation responses of healthcare system in Poland

    Science.gov (United States)

    Błażejczyk, Anna; Błażejczyk, Krzysztof; Baranowski, Jarosław; Kuchcik, Magdalena

    2018-03-01

    Heat stress is one of the environmental factors influencing the health of individuals and the wider population. There is a large body of research to document significant increases in mortality and morbidity during heat waves all over the world. This paper presents key results of research dealing with heat-related mortality (HRM) in various cities in Poland which cover about 25% of the country's population. Daily mortality and weather data reports for the years 1991-2000 were used. The intensity of heat stress was assessed by the universal thermal climate index (UTCI). The research considers also the projections of future bioclimate to the end of twenty-first century. Brain storming discussions were applied to find necessary adaptation strategies of healthcare system (HCS) in Poland, to minimise negative effects of heat stress. In general, in days with strong and very strong heat stress, ones must expect increase in mortality (in relation to no thermal stress days) of 12 and 47%, respectively. Because of projected rise in global temperature and heat stress frequency, we must expect significant increase in HRM to the end of twenty-first century of even 165% in comparison to present days. The results of research show necessity of urgent implementation of adaptation strategies to heat in HCS.

  20. Oxidative Stress in Oral Diseases: Understanding Its Relation with Other Systemic Diseases

    Directory of Open Access Journals (Sweden)

    Jaya Kumar

    2017-09-01

    Full Text Available Oxidative stress occurs in diabetes, various cancers, liver diseases, stroke, rheumatoid arthritis, chronic inflammation, and other degenerative diseases related to the nervous system. The free radicals have deleterious effect on various organs of the body. This is due to lipid peroxidation and irreversible protein modification that leads to cellular apoptosis or programmed cell death. During recent years, there is a rise in the oral diseases related to oxidative stress. Oxidative stress in oral disease is related to other systemic diseases in the body such as periodontitis, cardiovascular, pancreatic, gastric, and liver diseases. In the present review, we discuss the various pathways that mediate oxidative cellular damage. Numerous pathways mediate oxidative cellular damage and these include caspase pathway, PERK/NRF2 pathway, NADPH oxidase 4 pathways and JNK/mitogen-activated protein (MAP kinase pathway. We also discuss the role of inflammatory markers, lipid peroxidation, and role of oxygen species linked to oxidative stress. Knowledge of different pathways, role of inflammatory markers, and importance of low-density lipoprotein, fibrinogen, creatinine, nitric oxide, nitrates, and highly sensitive C-reactive proteins may be helpful in understanding the pathogenesis and plan better treatment for oral diseases which involve oxidative stress.

  1. Development of total systems of piping stress analysis and evaluation: ISAPPS

    International Nuclear Information System (INIS)

    Oki, Teizaburo; Koyanagi, Ryoichi; Fukuda, Masanao

    1978-01-01

    IHI has developed the systems of piping stress analysis and evaluation: ISAPPS (IHI Stress Analysis Program for Piping Systems), which are further described in this paper. In addition, the results of structural analysis and heat transfer analysis were confirmed. An example of stress evaluation in accordance with the modified ASME Code Sec. III is shown. ISAPPS consists of the following seven parts, and is designed for easy adoption of other programs by making modifications. 1. Piping design oriented language programs 2. Structural analysis programs 3. Isometric plotting programs 4. Multi-file dumping program 5. Load combination program 6. Heat transfer program 7. Stress evaluation programs As one of the examples of structural analysis programs, IHI make use of the modified SAP IV developed by the University of California. Evaluations of stresses are performed in accordance with: 1. ASME Boiler and Pressure Vessel Code, Sec. III Class 1, 2 and 3 2. ANSI Code, B31.1 and B31.3 3. MITI (Ministry of International Trade and Industry ) Code ISAPPS is very useful for design of nuclear and chemical pipings and so on. (author)

  2. Perceptions of stress, burnout, and support systems in pediatric bone marrow transplantation nursing.

    Science.gov (United States)

    Gallagher, Regan; Gormley, Denise K

    2009-12-01

    Bone marrow transplantation (BMT) is used to treat various conditions, ranging from immune disorders to many types of cancer. The critical complexity of patients and the environment in which BMT nurses work can lead to stress, burnout, and, ultimately, poor retention. This study aimed to investigate nurses' perceptions of work-related stress and burnout as well as current support systems for nurses. The study included 30 BMT staff nurses from a large pediatric medical center in the midwestern United States. Critical illness or acuity of patients was reported as the most stressful factor; long work hours was the least stressful factor. Most nurses perceived moderate to high levels of emotional exhaustion, and 33% reported moderate levels of depersonalization. Fifty percent perceived high levels of personal accomplishment, despite the critical illness or acuity of their patients, demanding patient families, rotating shifts, short staffing, and caring for dying patients. Most nurses felt that support systems were in place and that staff was accessible, but most respondents were undecided about the helpfulness of the support systems. Results suggest that support systems may significantly affect work satisfaction and feelings of accomplishment for BMT nurses.

  3. Stress in adolescents with a chronically ill parent: inspiration from Rolland's Family Systems-Illness model

    NARCIS (Netherlands)

    Sieh, D.S.; Dikkers, A.L.C.; Visser-Meily, J.M.A.; Meijer, A.M.

    2012-01-01

    This article was inspired by Rolland’s Family Systems-Illness (FSI) model, aiming to predict adolescent stress as a function of parental illness type. Ninety-nine parents with a chronic medical condition, 82 partners, and 158 adolescent children (51 % girls; mean age = 15.1 years) participated in

  4. Application of 2-dimensional coordinate system conversion in stress measurements with neutron diffraction

    International Nuclear Information System (INIS)

    Wang, D.-Q.; Hubbard, C.R.; Spooner, S.

    2000-01-01

    This paper will present a method and program to precisely calculate the coordinates in a positioner coordinate system from given sample position coordinates with a minimum number of neutron surface scans for three possible circumstances in stress and texture measurement using neutron diffraction

  5. Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems.

    Science.gov (United States)

    Yeung, Ellen W; Craggs, Jason G; Gizer, Ian R

    2017-11-01

    Alcohol use disorder (AUD) is highly comorbid with chronic pain (CP). Evidence has suggested that neuroadaptive processes characterized by reward deficit and stress surfeit are involved in the development of AUD and pain chronification. Neurological data suggest that shared genetic architecture associated with the reward and stress systems may contribute to the comorbidity of AUD and CP. This monograph first delineates the prevailing theories of the development of AUD and pain chronification focusing on the reward and stress systems. It then provides a brief summary of relevant neurological findings followed by an evaluation of evidence documented by molecular genetic studies. Candidate gene association studies have provided some initial support for the genetic overlap between AUD and CP; however, these results must be interpreted with caution until studies with sufficient statistical power are conducted and replications obtained. Genomewide association studies have suggested a number of genes (e.g., TBX19, HTR7, and ADRA1A) that are either directly or indirectly related to the reward and stress systems in the AUD and CP literature. Evidence reviewed in this monograph suggests that shared genetic liability underlying the comorbidity between AUD and CP, if present, is likely to be complex. As the advancement in molecular genetic methods continues, future studies may show broader central nervous system involvement in AUD-CP comorbidity. Copyright © 2017 by the Research Society on Alcoholism.

  6. The stress system in depression and neurodegeneration: Focus on the human hypothalamus

    NARCIS (Netherlands)

    Bao, A.-M.; Meynen, G.; Swaab, D.F.

    2008-01-01

    The stress response is mediated by the hypothalamo-pituitary-adrenal (HPA) system. Activity of the corticotropin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) forms the basis of the activity of the HPA-axis. The CRH neurons induce adrenocorticotropin (ACTH)

  7. Understanding alfalfa root systems and their rold in abiotic stress tolerance

    Science.gov (United States)

    The root system architecture (RSA) impacts the capacity of the plant for efficient water and nutrient uptake. Root phenes have been associated with productivity under stress conditions and persistence of perennial species. The objectives of this study were to identify root traits that increase produ...

  8. [Effect of External Irradiation and Immobilization Stress on the Reproductive System of Male Rats].

    Science.gov (United States)

    Vereschako, G G; Tshueshova, N V; Gorokh, G A; Kozlov, I G; Naumov, A D

    2016-01-01

    We studied the state of the reproductive system of male rats after irradiation at a dose of 2.0 Gy, immobilization stress (6 hours/day for 7 days) and their combined effects. On the 30th day after the combined treatment (37 days after irradiation) a decrease in the testicular weight by almost 50% compared with the control and lesions connected with the process of spermatogenesis are observed. In the remote period--on the 60th day (67th after irradiation) the effect of irradiation and irradiation in combination with immobilization stress leads to a sharp drop in the number of epididymal sperm (up to 18% of the control), and a reduction of their viability. The reaction ofthe reproductive system to the immobilization stress is expressed in a certain increase in the mass of the testes and epididymis, moderate imbalances in the composition of spermatogenic cells in the testis tissue, and in the long term--in the increased number of epididymal sperm and the decrease in their viability. Changes of testosterone in the blood serum, especially significant for the combined effect, reflect impairments of the regulation of the reproductive system of males under these conditions. With regard to individual indicators of the reproductive system of male rats in some cases, the- combined effects of radiation and stress had a synergistic, or, on the contrary, antagonistic character.

  9. Enhancing resilience of farmer seed system to climate-induced stresses

    NARCIS (Netherlands)

    Kansiime, Monica K.; Mastenbroek, Astrid

    2016-01-01

    Given the challenges facing African agriculture resulting from climate-induced stresses, building resilience is a priority. Seed systems are important for enhancing such resilience as seed security has direct links to food security, and resilient livelihoods in general. Using data from a case

  10. IMMORTALIZED MICROGLIAL CELLS AS A MODEL SYSTEM FOR OXIDATIVE STRESS: PESTICIDE-INDUCED GENOMIC GHANGES.

    Science.gov (United States)

    In risk assessment there is a need to accelerate toxicological evaluation of vast numbers of chemicals. New programs focus on identifying common modes of action and on model systems for rapid screening. In this study we address both these issues. Oxidative stress is a good can...

  11. Dicarbonyl stress and glyoxalase enzyme system regulation in human skeletal muscle.

    Science.gov (United States)

    Mey, Jacob T; Blackburn, Brian K; Miranda, Edwin R; Chaves, Alec B; Briller, Joan; Bonini, Marcelo G; Haus, Jacob M

    2018-02-01

    Skeletal muscle insulin resistance is a hallmark of Type 2 diabetes (T2DM) and may be exacerbated by protein modifications by methylglyoxal (MG), known as dicarbonyl stress. The glyoxalase enzyme system composed of glyoxalase 1/2 (GLO1/GLO2) is the natural defense against dicarbonyl stress, yet its protein expression, activity, and regulation remain largely unexplored in skeletal muscle. Therefore, this study investigated dicarbonyl stress and the glyoxalase enzyme system in the skeletal muscle of subjects with T2DM (age: 56 ± 5 yr.; BMI: 32 ± 2 kg/m 2 ) compared with lean healthy control subjects (LHC; age: 27 ± 1 yr.; BMI: 22 ± 1 kg/m 2 ). Skeletal muscle biopsies obtained from the vastus lateralis at basal and insulin-stimulated states of the hyperinsulinemic (40 mU·m -2 ·min -1 )-euglycemic (5 mM) clamp were analyzed for proteins related to dicarbonyl stress and glyoxalase biology. At baseline, T2DM had increased carbonyl stress and lower GLO1 protein expression (-78.8%), which inversely correlated with BMI, percent body fat, and HOMA-IR, while positively correlating with clamp-derived glucose disposal rates. T2DM also had lower NRF2 protein expression (-31.6%), which is a positive regulator of GLO1, while Keap1 protein expression, a negative regulator of GLO1, was elevated (207%). Additionally, insulin stimulation during the clamp had a differential effect on NRF2, Keap1, and MG-modified protein expression. These data suggest that dicarbonyl stress and the glyoxalase enzyme system are dysregulated in T2DM skeletal muscle and may underlie skeletal muscle insulin resistance. Whether these phenotypic differences contribute to the development of T2DM warrants further investigation.

  12. Effects of psychosocial stress on the goal-directed and habit memory systems during learning and later execution.

    Science.gov (United States)

    Fournier, Marion; d'Arripe-Longueville, Fabienne; Radel, Rémi

    2017-03-01

    Instrumental learning occurs through both goal-directed and habit memory systems, which are supported by anatomically distinct brain systems. Interestingly, stress may promote habits at the expense of goal-directed performance, since stress before training in an instrumental task was found to cause individuals to carry on with the learned association in spite of a devalued outcome. These findings nevertheless left pending questions, and it has been difficult to determine which system is primarily affected by stress (an improved habit system, an impaired goal-directed system, or both) and at what point the stress acts (at the moment of learning by making more resistant habits, or after devaluation by making individuals less sensitive to change in the outcome value). The present study (N=72 participants, 63 males and 9 females) aimed to answer these questions with (i) an instrumental task that dissociates the two memory systems and (ii) three conditions of psychosocial stress exposure (Trier Social Stress Test): stress induced before learning, before devaluation, and not induced for the control group. The study confirms that exposure to psychosocial stress leads to habitual performance. Moreover, it provides new insight into this effect by locating its origin as an impairment in the capacity of the goal-directed system rather than a reinforcement in habit learning. These results are discussed in light of recent neurobiological models of stress and memory. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Mission Profile Translation to Capacitor Stresses in Grid-Connected Photovoltaic Systems

    DEFF Research Database (Denmark)

    Yang, Yongheng; Ma, Ke; Wang, Huai

    2014-01-01

    DC capacitors are widely adopted in grid-connected PhotoVoltaic(PV) systems for power stabilization and control decoupling. They have become one of the critical components in grid-connected PV inverters in terms of cost, reliability and volume. The electrical and thermal stresses of the DC...... stresses of the DC capacitors under both normal and abnormal grid conditions. As a consequence, this investigation provides new insights into the sizing and reliability prediction of those capacitors with respect to priorart studies. Two study cases on a single-stage PV inverter and a two-stage PV inverter...

  14. Stress Corrosion Evaluation of Various Metallic Materials for the International Space Station Water Recycling System

    Science.gov (United States)

    Torres, P. D.

    2015-01-01

    A stress corrosion evaluation was performed on Inconel 625, Hastelloy C276, titanium commercially pure (TiCP), Ti-6Al-4V, Ti-6Al-4V extra low interstitial, and Cronidur 30 steel as a consequence of a change in formulation of the pretreatment for processing the urine in the International Space Station Environmental Control and Life Support System Urine Processing Assembly from a sulfuric acid-based to a phosphoric acid-based solution. The first five listed were found resistant to stress corrosion in the pretreatment and brine. However, some of the Cronidur 30 specimens experienced reduction in load-carrying ability.

  15. Combined action of radiation and immobilization stress on reproductive system male rats station

    International Nuclear Information System (INIS)

    Vereshchako, G.G.; Chueshova, N.V.; Gorokh, G.A.; Naumov, A.D.

    2015-01-01

    It was studied the effect of irradiation (0.5 Gy), immobilization stress (3 hours/day for 7 days), and their combined effect on the reproductive system of male rats. The action of these factors, individually or together caused a significant imbalance quantitative composition of the spermatogenic cells in the testis tissue, marked decrease the viability of epididymal spermatozoa, and increased DNA fragmentation in them, which may result in reduced fertility of animals. Under these influences reproductive disorders save for a long time. In some cases, the effects of the combined action of irradiation and immobilization stress is significantly higher than the isolated action of each of them. (authors)

  16. Redox and Ionic Homeostasis Regulations against Oxidative, Salinity and Drought Stress in Wheat (A Systems Biology Approach

    Directory of Open Access Journals (Sweden)

    Zahid Hussain Shah

    2017-10-01

    Full Text Available Systems biology and omics has provided a comprehensive understanding about the dynamics of the genome, metabolome, transcriptome, and proteome under stress. In wheat, abiotic stresses trigger specific networks of pathways involved in redox and ionic homeostasis as well as osmotic balance. These networks are considerably more complicated than those in model plants, and therefore, counter models are proposed by unifying the approaches of omics and stress systems biology. Furthermore, crosstalk among these pathways is monitored by the regulation and streaming of transcripts and genes. In this review, we discuss systems biology and omics as a promising tool to study responses to oxidative, salinity, and drought stress in wheat.

  17. The Autonomous Stress Indicator for Remotely Monitoring Power System State and Watching for Potential Instability

    Directory of Open Access Journals (Sweden)

    Geza Joos

    2009-02-01

    Full Text Available The proposed Autonomous Stress Indicator (ASI is a device that monitors the contents of the protection relays on a suspect weak power system bus and generates a performance level related to the degree of system performance degradation or instability. This gives the system operators some time (minutes to take corrective action. In a given operating area there would not likely be a need for an ASI on every bus. Note that the ASI does not trip any breakers; it is an INFORMATION ONLY device. An important feature is that the system operator can subsequently interrogate the ASI to determine the factor(s that led to the performance level that has been initially annunciated, thereby leading to a course of action. This paper traces the development of the ASI which is an ongoing project. The ASI could be also described as a stress-alert device whose function is to alert the System Operator of a stressful condition at its location. The characteristics (or essential qualities of this device are autonomy, selectivity, accuracy and intelligence. These will fulfill the requirements of the recommendation of the Canada –US Task Force in the August 2003 system collapse. Preliminary tests on the IEEE 39-bus model indicate that the concept has merit and development work is in progress. While the ASI can be applied to all power system operating conditions, its principal application is to the degraded state of the system where the System Operator must act to restore the system to the secure state before it migrates to a stage of collapse. The work of ASI actually begins with the Areas of Vulnerability and ends with the Predictive Module as described in detail in this paper. An application example of a degraded system using the IEEE 39-bus system is included.

  18. Strength of SiCf-SiCm composite tube under uniaxial and multiaxial loading

    Science.gov (United States)

    Shapovalov, Kirill; Jacobsen, George M.; Alva, Luis; Truesdale, Nathaniel; Deck, Christian P.; Huang, Xinyu

    2018-03-01

    The authors report mechanical strength of nuclear grade silicon carbide fiber reinforced silicon carbide matrix composite (SiCf-SiCm) tubing under several different stress states. The composite tubing was fabricated via a Chemical Vapor Infiltration (CVI) process, and is being evaluated for accident tolerant nuclear fuel cladding. Several experimental techniques were applied including uniaxial tension, elastomer insert burst test, open and closed end hydraulic bladder burst test, and torsion test. These tests provided critical stress and strain values at proportional limit and at ultimate failure points. Full field strain measurements using digital image correlation (DIC) were obtained in order to acquire quantitative information on localized deformation during application of stress. Based on the test results, a failure map was constructed for the SiCf-SiCm composites.

  19. Modelling and analysis of the stress distribution in a multi-thin film system Pt/USG/Si

    Science.gov (United States)

    Yao, W. Z.; Roqueta, F.; Craveur, J. C.; Belhenini, S.; Gardes, P.; Tougui, A.

    2018-04-01

    Residual stress analysis is commonly achieved through curvature measurement with the help of Stoney’s formula. However, this conventional approach is inadequate for multi-layer thin film systems, which are widely used in today’s microelectronics. Also, for the thin film case, the residual stress is composed of thermal stress and intrinsic stress. Measuring the wafer curvature at room temperature provides a value for the average stresses in the layer, the two components cannot be distinguished by the existing methodologies of curvature measurement. To alleviate these problems, a modified curvature method combining finite element (FE) modelling is proposed to study the stress distribution in a Pt/USG/Si structure. A 2D FE model is firstly built in order to calculate the thermal stress in the multilayer structure, the obtained thermal stresses in respective films are verified by an analytical model. Then, we calculate the warpage of the multilayer structure by considering the intrinsic stress in the respective films. The residual stresses in the films are determined by minimizing the difference between the simulated warpage and that of experimental measurement. The proposed approach can be used to calculate not only the average residual stress but also thermal and intrinsic stress components in the USG and Platinum films. The obtained residual and intrinsic stresses from a numerical model are compared with the values of other studies. There is no limitation for the application of our methodologies regarding the number of the layers in the stack.

  20. Chronic Stress and Limbic-Hypothalamopituitary-Adrenal Axis (LHPA Response in Female Reproductive system

    Directory of Open Access Journals (Sweden)

    Farideh Zafari Zangeneh

    2009-12-01

    Full Text Available The hypothalamo-pituitary-adrenocortical (HPA axis is a critical adaptive system that maximizes survival potential in the face of physical or psychological challenge. The principal end products of the HPA axis, glucocorticoid hormones, act on multiple organ systems, including the brain, to maintain homeostatic balance. The brain is a target of stress, and the hippocampus is the first brain region, besides the hypothalamus, to be recognized as a target of glucocorticoids. These anatomical areas in brain are limbic system, and in particular the hippocampus, medial prefrontal cortex (mPFC and amigdal that have multiple control points in regulation of the hypothalamic–pituitary–adrenal (HPA axis. The studies show the prefrontal cortex (PFC plays an important role in the regulation of stress-induced hypothalamic–pituitary–adrenal (HPA activity and regulation of gonadal function in men and women is under the control of the HPA. This regulation is complex and sex steroids are important regulators of GnRH and gonadotropin release through classic feedback mechanisms in the hypothalamus and pituitary gland. Chronic stress can have a deleterious effect on the reproductive axis that, for females, is manifested in reduced pulsatile gonadotropin secretion and increased incidence of ovulatory abnormalities and infertility. The limbic–hypothalamic–pituitary–adrenal (LHPA axis suggests a functional role for gonadal steroids in the regulation of a female’s response to stress.

  1. Osteoarchaeological Studies of Human Systemic Stress of Early Urbanization in Late Shang at Anyang, China

    Science.gov (United States)

    Zhang, Hua; Merrett, Deborah C.; Jing, Zhichun; Tang, Jigen; He, Yuling; Yue, Hongbin; Yue, Zhanwei; Yang, Dongya Y.

    2016-01-01

    Through the analysis of human skeletal remains and mortuary practice in Yinxu, this study investigates the impact of early urbanization on the commoners during the Late Shang dynasty (ca. 1250–1046 B.C.). A total of 347 individuals examined in this study represent non-elites who were recovered from two different burial contexts (formally buried in lineage cemeteries and randomly scattered in refuse pits). Frequencies of enamel hypoplasia (childhood stress), cribra orbitalia (childhood stress and frailty) and osteoperiostitis (adult stress) were examined to assess systemic stress exposure. Our results reveal that there was no significant difference in the frequency of enamel hypoplasia between two burial groups and between sexes, suggesting these urban commoners experienced similar stresses during childhood, but significantly elevated levels of cribra orbitalia and osteoperiostitis were observed in the refuse pit female cohort. Theoretically, urbanization would have resulted in increased population density in the urban centre, declining sanitary conditions, and increased risk of resource shortage. Biologically, children would be more vulnerable to such physiological disturbance; as a result, high percentages of enamel hypoplasia (80.9% overall) and cribra orbitalia (30.3% overall) are observed in Yin commoners. Adults continued to suffer from stress, resulting in high frequencies of osteoperiostitis (40.0% total adults); in particular, in the refuse pit females who may also reflect a compound impact of gender inequality. Our data show that the non-elite urban population in the capital city of Late Shang Dynasty had experienced extensive stress exposure due to early urbanization with further social stratification only worsening the situation, and eventually contributing to collapse of the Shang Dynasty. PMID:27050400

  2. Thermal stress comparison in modular power converter topologies for smart transformers in the electrical distribution system

    DEFF Research Database (Denmark)

    Andresen, Markus; Ma, Ke; Liserre, Marco

    2015-01-01

    A Smart Transformer (ST) can cover an important managing role in the future electrical distribution grid. For the moment, the reliability and cost are not competitive with traditional transformers and create a barrier for its application. This work conduct detail designs and analysis...... for a promising modular ST solution, which is composed of Modular Multi-level converter, Quad Active Bridge DC-DC converters, and two-level voltage source converters. The focus is put on the loading conditions and thermal stress of power semiconductor devices in order to discover critical parts of the whole...... system when performing various mission profiles in the realistic distribution grid. It is concluded that the thermal stress for all stages is low during normal operation and especially the isolation stage is stressed least....

  3. Immune System Dysregulation, Viral Reactivation and Stress During Short-Duration Space Flight

    Science.gov (United States)

    Crucian, Brian; Mehta, Satish; Stowe, Raymond; Uchakin, Peter; Quiriarte, Heather; Pierson, Duane; Sams, Clarence

    2010-01-01

    This slide presentation reviews a study that was conducted to ascertain if the immune system dysregulation, viral reactivation and stress from short duration space flight were a result of the stress of landing and readjustment to gravity. The objectives of the study were to replace several recent immune studies with one comprehensive study that will include in-flight sampling; address lack of in-flight data: (i.e., determine the in-flight status of immunity, physiological stress, viral immunity/reactivation); determine the clinical risk related to immune dysregulation for exploration class spaceflight; and determine the appropriate monitoring strategy for spaceflight-associated immune dysfunction, that could be used for the evaluation of countermeasures.

  4. New evidence on the state of stress of the san andreas fault system.

    Science.gov (United States)

    Zoback, M D; Zoback, M L; Mount, V S; Suppe, J; Eaton, J P; Healy, J H; Oppenheimer, D; Reasenberg, P; Jones, L; Raleigh, C B; Wong, I G; Scotti, O; Wentworth, C

    1987-11-20

    Contemporary in situ tectonic stress indicators along the San Andreas fault system in central California show northeast-directed horizontal compression that is nearly perpendicular to the strike of the fault. Such compression explains recent uplift of the Coast Ranges and the numerous active reverse faults and folds that trend nearly parallel to the San Andreas and that are otherwise unexplainable in terms of strike-slip deformation. Fault-normal crustal compression in central California is proposed to result from the extremely low shear strength of the San Andreas and the slightly convergent relative motion between the Pacific and North American plates. Preliminary in situ stress data from the Cajon Pass scientific drill hole (located 3.6 kilometers northeast of the San Andreas in southern California near San Bernardino, California) are also consistent with a weak fault, as they show no right-lateral shear stress at approximately 2-kilometer depth on planes parallel to the San Andreas fault.

  5. Interaction of basal forebrain cholinergic neurons with the glucocorticoid system in stress regulation and cognitive impairment

    Directory of Open Access Journals (Sweden)

    Saswati ePaul

    2015-04-01

    Full Text Available A substantial number of studies on basal forebrain cholinergic neurons (BFCN have provided compelling evidence for their role in the etiology of stress, cognitive aging, Alzheimer’s disease (AD, and other neurodegenerative diseases. BFCN project to a broad range of cortical sites and limbic structures, including the hippocampus, and are involved in stress and cognition. In particular, the hippocampus, the primary target tissue of the glucocorticoid stress hormones, is associated with cognitive function in tandem with hypothalamic-pituitary-adrenal (HPA axis modulation. The present review summarizes glucocorticoid and HPA axis research to date in an effort to establish the manner in which stress affects the release of acetylcholine, glucocorticoids, and their receptor in the context of cognitive processes. We attempt to provide the molecular interactive link between the glucocorticoids and cholinergic system that contributes to BFCN degeneration in stress-induced acceleration of cognitive decline in aging and AD. We also discuss the importance of animal models in facilitating such studies for pharmacological use, which could help decipher disease states and propose leads for pharmacological intervention.

  6. The beginnings of crop phosphoproteomics: exploring early warning systems of stress.

    Directory of Open Access Journals (Sweden)

    Christof eRampitsch

    2012-07-01

    Full Text Available This review examines why a knowledge of plant protein phosphorylation events is important in devising strategies to protect crops from both biotic and abiotic stresses, and why proteomics should be included when studying stress pathways. Most of the achievements in elucidating phospho-signalling pathways in biotic and abiotic stress are reported from model systems: while these are discussed, this review attempts mainly to focus on work done with crops, with examples of achievements reported from rice, maize, wheat, grape, Brassica, tomato and soy bean after cold acclimation, hormonal and oxidative H2O2 treatment, salt stress, mechanical wounding or pathogen challenge. The challenges that remain to transfer this information into a format that can be used to protect crops against biotic and abiotic stresses are enormous. The tremendous increase in the speed and ease of DNA sequencing is poised to reveal the whole genomes of many crop species in the near future, which will facilitate phosphoproteomics and phosphogenomics research.

  7. An education management information system with simultaneous monitoring of stress stimulators for students Mental Health management.

    Science.gov (United States)

    Manimaran, S; Jayakumar, S; Lakshmi, K Bhagya

    2016-11-14

    Education Management Information System (EMIS) is a widely acceptable and developing technology within the Information Technology field. The advancement in technology in this century is being collaborated with scientific invention or explorer and information strengthening or development. This paper presents the results and experiences gained from applying students oriented EMIS for monitoring and managing mental health. The Mental Health of students depends on the acquiring adequate knowledge on basic concepts within a time period or academic schedule. It's obviously significance to evaluate and appraise the stress stimulators as a challenge or threat. The theoretical framework for the study was designed for analyzing the stress stimulators, academic performance and EMIS accessibility. The sample examined in this study was stratified random sample from 75 students specifically all engineering college in Dindigul District of Tamilnadu. The primary factor is the academic stress stimulators that form one module of EMIS for each of the key variable such as curriculum & instruction related stressors, placement related, teamwork related and assessment related. The Mental Health related stress stimulators namely curriculum & syllabus, placement related, assessment related and team work related have a significant influence on academic performance by students in various institution. The important factor leading to the EMIS application in monitoring stress stimulators is curriculum & syllabus related and assessment related.

  8. Cultivation of shear stress sensitive microorganisms in disposable bag reactor systems.

    Science.gov (United States)

    Jonczyk, Patrick; Takenberg, Meike; Hartwig, Steffen; Beutel, Sascha; Berger, Ralf G; Scheper, Thomas

    2013-09-20

    Technical scale (≥5l) cultivations of shear stress sensitive microorganisms are often difficult to perform, as common bioreactors are usually designed to maximize the oxygen input into the culture medium. This is achieved by mechanical stirrers, causing high shear stress. Examples for shear stress sensitive microorganisms, for which no specific cultivation systems exist, are many anaerobic bacteria and fungi, such as basidiomycetes. In this work a disposable bag bioreactor developed for cultivation of mammalian cells was investigated to evaluate its potential to cultivate shear stress sensitive anaerobic Eubacterium ramulus and shear stress sensitive basidiomycetes Flammulina velutipes and Pleurotus sapidus. All cultivations were compared with conventional stainless steel stirred tank reactors (STR) cultivations. Good growth of all investigated microorganisms cultivated in the bag reactor was found. E. ramulus showed growth rates of μ=0.56 h⁻¹ (bag) and μ=0.53 h⁻¹ (STR). Differences concerning morphology, enzymatic activities and growth in fungal cultivations were observed. In the bag reactor growth in form of small, independent pellets was observed while STR cultivations showed intense aggregation. F. velutipes reached higher biomass concentrations (21.2 g l⁻¹ DCW vs. 16.8 g l⁻¹ DCW) and up to 2-fold higher peptidolytic activities in comparison to cell cultivation in stirred tank reactors. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. Hydrodynamic Study of a Hollow Fiber Membrane System Using Experimental and Numerical Derived Surface Shear Stresses

    DEFF Research Database (Denmark)

    Ratkovich, Nicolas Rios; Hunze, M.; Nopens, I.

    2012-01-01

    .39 – 0.69 Pa) were in good agreement, with an error less that 15 %. Based on comparison of the cumulative frequency distribution of shear stresses from experiments and simulation: (i) moderate shear stresses (i.e. 50th percentile) were found to be accurately predicted (model: 0.24 – 0.45 Pa; experimental......Computational Fluids Dynamics (CFD) models can be used to gain insight into the shear stresses induced by air sparging on submerged hollow fiber Membrane BioReactor (MBR) systems. It was found that the average range of shear stresses obtained by the CFD model (0.30 – 0.60 Pa) and experimentally (0......: 0.25 – 0.49 Pa) with an error of less than 5 %; (ii) high shear stresses (i.e. 90th percentile) predictions were much less accurate (model: 0.60 – 1.23 Pa; experimental: 1.04 – 1.90 Pa) with an error up to 38 %. This was attributed to the fact that the CFD model only considers the two-phase flow (50...

  10. Roots Withstanding their Environment: Exploiting Root System Architecture Responses to Abiotic Stress to Improve Crop Tolerance

    Science.gov (United States)

    Koevoets, Iko T.; Venema, Jan Henk; Elzenga, J. Theo. M.; Testerink, Christa

    2016-01-01

    To face future challenges in crop production dictated by global climate changes, breeders and plant researchers collaborate to develop productive crops that are able to withstand a wide range of biotic and abiotic stresses. However, crop selection is often focused on shoot performance alone, as observation of root properties is more complex and asks for artificial and extensive phenotyping platforms. In addition, most root research focuses on development, while a direct link to the functionality of plasticity in root development for tolerance is often lacking. In this paper we review the currently known root system architecture (RSA) responses in Arabidopsis and a number of crop species to a range of abiotic stresses, including nutrient limitation, drought, salinity, flooding, and extreme temperatures. For each of these stresses, the key molecular and cellular mechanisms underlying the RSA response are highlighted. To explore the relevance for crop selection, we especially review and discuss studies linking root architectural responses to stress tolerance. This will provide a first step toward understanding the relevance of adaptive root development for a plant’s response to its environment. We suggest that functional evidence on the role of root plasticity will support breeders in their efforts to include root properties in their current selection pipeline for abiotic stress tolerance, aimed to improve the robustness of crops. PMID:27630659

  11. Manganese scavenging and oxidative stress response mediated by type VI secretion system in Burkholderia thailandensis.

    Science.gov (United States)

    Si, Meiru; Zhao, Chao; Burkinshaw, Brianne; Zhang, Bing; Wei, Dawei; Wang, Yao; Dong, Tao G; Shen, Xihui

    2017-03-14

    Type VI secretion system (T6SS) is a versatile protein export machinery widely distributed in Gram-negative bacteria. Known to translocate protein substrates to eukaryotic and prokaryotic target cells to cause cellular damage, the T6SS has been primarily recognized as a contact-dependent bacterial weapon for microbe-host and microbial interspecies competition. Here we report contact-independent functions of the T6SS for metal acquisition, bacteria competition, and resistance to oxidative stress. We demonstrate that the T6SS-4 in Burkholderia thailandensis is critical for survival under oxidative stress and is regulated by OxyR, a conserved oxidative stress regulator. The T6SS-4 is important for intracellular accumulation of manganese (Mn 2+ ) under oxidative stress. Next, we identified a T6SS-4-dependent Mn 2+ -binding effector TseM, and its interacting partner MnoT, a Mn 2+ -specific TonB-dependent outer membrane transporter. Similar to the T6SS-4 genes, expression of mnoT is regulated by OxyR and is induced under oxidative stress and low Mn 2+ conditions. Both TseM and MnoT are required for efficient uptake of Mn 2+ across the outer membrane under Mn 2+ -limited and -oxidative stress conditions. The TseM-MnoT-mediated active Mn 2+ transport system is also involved in contact-independent bacteria-bacteria competition and bacterial virulence. This finding provides a perspective for understanding the mechanisms of metal ion uptake and the roles of T6SS in bacteria-bacteria competition.

  12. Stress on Cold Mass Due to the Supporting System of the CMS Coil in the Vacuum Tank

    CERN Document Server

    Farinon, S

    2000-01-01

    This report contains a verification analysis of the stress on cold mass coming from the supporting system of the CMS coil in the vacuum tank. The need to carry out this analysis is related to the high mechanical requirements for $9 Al-alloy mandrels (218 MPa yield at cryogenic temperature), demanding accurate analysis of the impact of supporting system on cylinder stress.

  13. Constitutive Relations of Randomly Oriented Steel Fiber Reinforced Concrete under Multiaxial Compressive Loadings,

    Science.gov (United States)

    1981-12-01

    xe yz Tzy + ay* Tzx Txz + Oz y 1; ryxIL 335 Pa = atmospheric pressure (positive) in the same (5.46) units as the stresses (Compression Positiv e...straight * "Fibercon" fibers. Quantitative values of the strengths with percentage improvements over the same plain concrete mix properties are given

  14. A multi-axis confocal rheoscope for studying shear flow of structured fluids

    KAUST Repository

    Lin, Neil Y. C.; McCoy, Jonathan H.; Cheng, Xiang; Leahy, Brian; Israelachvili, Jacob N.; Cohen, Itai

    2014-01-01

    of confinement effects. By using our shear cell in conjunction with a biaxial force measurement device and a high-speed confocal microscope, we are able to measure the real-time biaxial stress while simultaneously imaging the material three-dimensional structure

  15. Changes in Galanin Systems in a Rat Model of Post-Traumatic Stress Disorder (PTSD).

    Science.gov (United States)

    Barnabas, Karen; Zhang, Lin; Wang, Huiying; Kirouac, Gilbert; Vrontakis, Maria

    2016-01-01

    Post-traumatic stress disorder (PTSD) is a chronic syndrome triggered by exposure to trauma and a failure to recover from a normal negative emotional reaction to traumatic stress. The neurobiology of PTSD and the participation of neuropeptides in the neural systems and circuits that control fear and anxiety are not fully understood. The long-term dysregulation of neuropeptide systems contributes to the development of anxiety disorders, including PTSD. The neuropeptide galanin (Gal) and its receptors participate in anxiety-like and depression-related behaviors via the modulation of neuroendocrine and monoaminergic systems. The objective of this research was to investigate how Gal expression changes in the brain of rats 2 weeks after exposure to footshock. Rats exposed to footshocks were subdivided into high responders (HR; immobility>60%) and low responders (LR; immobilityPTSD development.

  16. Buddhism-as-a-meaning-system for coping with late-life stress: a conceptual framework.

    Science.gov (United States)

    Xu, Jianbin

    2018-01-01

    Religion is increasingly conceptualized as a meaning system for adjustment and coping. Most of the conceptualizations are grounded in the Judeo-Christian tradition. They may thus not be applicable to Buddhism, which provides a distinct tenor of meaning for coping. This article seeks to construct a conceptual framework of Buddhism-as-a-meaning-system for coping with late-life stress. Literature review and conceptualization were employed. Under this framework, Buddhism functions as a meaning system involving existential meaning, cognitive meaning, and behavioral meaning. There is reason to believe that this framework promises to offer a holistic conceptual map of Buddhist coping in late life. Thus, it could serve as a guide for further empirical and theoretical exploration in the uncharted terrains of Buddhist coping in old age. In addition, gerontological practitioners could use this framework as a frame of reference when working with elderly Buddhist clients who are in stressful circumstances.

  17. Importance of silvopastoral systems on caloric stress reduction in tropical livestock productions

    Directory of Open Access Journals (Sweden)

    Alexander Navas Panadero

    2010-06-01

    Full Text Available Livestock systems in Colombia have been developed taking concepts and technologies from the green revolution, where gramineous monocrop is privileged over arboreal cover in grazing lands. This model has not taken into account the climatic conditions of the different tropical ecosystems, in which variables as temperature, relative humidity and evaporation can limit the animal´s productive and reproductive efficiency, besides being a risk factor for illness occurrence in the herd. Bos Taurus and Bos Indicus breeds show termoneutral ranges where its genetic potential can be express. However, out of this comfort area animals can enter in caloric stress which in consequence reduces its performance and sometimes can end up causing death. Silvopastoral systems comprise several functions; it contributes to lessen caloric stress since temperature under the tree canopy can reach between 2 and 9°C lower in comparison to open pastures. Differences in temperature reduction have been found among silvopastoral systems and species, being the tree group arrangements and the species with high density canopy, those with superior effect. Interactions among components should be analyzed in order to design systems that incorporate enough arboreal cover to achieve caloric stress reductions, but without affecting forage production in pastures. Silvopastoral systems contribute to improve animal welfare.

  18. IEA-R1 primary and secondary coolant piping systems coupled stress analysis

    International Nuclear Information System (INIS)

    Fainer, Gerson; Faloppa, Altair A.; Oliveira, Carlos A.; Mattar Neto, Miguel

    2013-01-01

    The aim of this work is to perform the stress analysis of a coupled primary and secondary piping system of the IEA-R1 based on tridimensional model, taking into account the as built conditions. The nuclear research reactor IEA-R1 is a pool type reactor projected by Babcox-Willcox, which is operated by IPEN since 1957. The operation to 5 MW power limit was only possible after the conduction of life management and modernization programs in the last two decades. In these programs the components of the coolant systems, which are responsible for the water circulation into the reactor core to remove the heat generated inside it, were almost totally refurbished. The changes in the primary and secondary systems, mainly the replacement of pump and heat-exchanger, implied in piping layout modifications, and, therefore, the stress condition of the piping systems had to be reanalyzed. In this paper the structural stress assessment of the coupled primary and secondary piping systems is presented and the final results are discussed. (author)

  19. Investigation of effective factors of transient thermal stress of the MONJU-System components

    Energy Technology Data Exchange (ETDEWEB)

    Inoue, Masaaki; Hirayama, Hiroshi; Kimura, Kimitaka; Jinbo, M. [Toshiba Corp., Kawasaki, Kanagawa (Japan)

    1999-03-01

    Transient thermal stress of each system Component in the fast breeder reactor is an uncertain factor on it's structural design. The temperature distribution in a system component changes over a wide range in time and in space. An unified evaluation technique of thermal, hydraulic, and structural analysis, in which includes thermal striping, temperature stratification, transient thermal stress and the integrity of the system components, is required for the optimum design of tho fast reactor plant. Thermal boundary conditions should be set up by both the transient thermal stress analysis and the structural integrity evaluation of each system component. The reasonable thermal boundary conditions for the design of the MONJU and a demonstration fast reactor, are investigated. The temperature distribution analysis models and the thermal boundary conditions on the Y-piece structural parts of each system component, such as reactor vessel, intermediate heat exchanger, primary main circulation pump, steam generator, superheater and upper structure of reactor core, are illustrated in the report. (M. Suetake)

  20. Neuromuscular Stress.

    Science.gov (United States)

    White, Timothy P.; Kern, Marialice

    1994-01-01

    Discusses exercise-induced stress that results from motor unit recruitment, the impact of recruitment on selected systemic support systems, and some of the environmental overlays that affect the degree of physiological stress. Adaptations to sustained changes in physical activity and muscle and myotendinous injury induced by stress are examined.…

  1. Stress and Systemic Inflammation: Yin-Yang Dynamics in Health and Diseases.

    Science.gov (United States)

    Yan, Qing

    2018-01-01

    Studies in psychoneuroimmunology (PNI) would provide better insights into the "whole mind-body system." Systems biology models of the complex adaptive systems (CASs), such as a conceptual framework of "Yin-Yang dynamics," may be helpful for identifying systems-based biomarkers and targets for more effective prevention and treatment. The disturbances in the Yin-Yang dynamical balance may result in stress, inflammation, and various disorders including insomnia, Alzheimer's disease, obesity, diabetes, cardiovascular diseases, skin disorders, and cancer. At the molecular and cellular levels, the imbalances in the cytokine pathways, mitochondria networks, redox systems, and various signaling pathways may contribute to systemic inflammation. In the nervous system, Yin and Yang may represent the dynamical associations between the progressive and regressive processes in aging and neurodegenerative diseases. In response to the damages to the heart, the Yin-Yang dynamical balance between proinflammatory and anti-inflammatory cytokine networks is crucial. The studies of cancer have revealed the importance of the Yin-Yang dynamics in the tumoricidal and tumorigenic activities of the immune system. Stress-induced neuroimmune imbalances are also essential in chronic skin disorders including atopic dermatitis and psoriasis. With the integrative framework, the restoration of the Yin-Yang dynamics can become the objective of dynamical systems medicine.

  2. Residual stress measurements by means of neutron diffraction

    International Nuclear Information System (INIS)

    Pintschovius, L.; Jung, V.; Macherauch, E.; Voehringer, O.

    1983-01-01

    A new method for the analysis of multiaxial residual stress states is presented, which is based on high resolution neutron diffraction. It is analogous to X-ray stress analysis, but the use of neutrons instead of X-rays allows the analysis of the stress distributions also in the interior of technical components in a non-destructive way. To prove the feasibility of the method, investigations of the loading stress distributions of an aluminium bar subjected to purely elastic bending were performed. Limiting factors due to the volume of the internal probe region and the sample thickness are discussed. Complete neutron residual stress analyses were carried out for a plastically deformed bending bar and a transformation-free water-quenched steel cylinder. The results are in fairly good agreement with theoretical expectations and with X-ray control measurements at the surface of the objects. (Auth.)

  3. A Hydraulic Stress Measurement System for Investigations at Depth in Slim Boreholes

    Science.gov (United States)

    Ask, M. V. S.; Ask, D.; Cornet, F. H.; Nilsson, T.; Talib, M.; Sundberg, J.

    2017-12-01

    Knowledge of the state of stress is essential to most underground work in rock mechanics as it provides means to analyze the mechanical behavior of a rock mass, serve as boundary condition in rock engineering problems, and help understand rock mass stability and groundwater flow. Luleå University of Technology (LTU) has developed and built a wire-line system for hydraulic rock stress measurements in slim boreholes together with the University of Strasbourg and Geosigma AB. The system consists of a downhole- and a surface unit. The downhole unit consists of hydraulic fracturing equipment (straddle packers and downhole imaging tool) and their associated data acquisition systems. The surface unit comprises of a 40-foot container permanently mounted on a trailer, which is equipped with a tripod, wire-line winches, water hydraulics, and a generator. The surface unit serves as a climate-independent on-site operations center, as well as a self-supporting transport vessel for the entire system. Three hydraulic stress testing methods can be applied: hydraulic fracturing, sleeve fracturing and hydraulic testing of pre-existing fractures. The three-dimensional stress tensor and its variation with depth within a continuous rock mass can be determined in a scientific unambiguously way by integrating results from the three test methods. The testing system is state of the art in several aspects including: (1) Large depth range (3 km), (2) Ability to test three borehole dimensions, (3) Resistivity imager maps the orientation of tested fracture (which is highlighted); (4) Highly stiff and resistive to corrosion downhole testing equipment; and (5) Very detailed control on the injection flow rate and cumulative volume is obtained by a hydraulic injection pump with variable piston rate, and a highly sensitive flow-meter. These aspects highly reduce measurement-related uncertainties of stress determination. Commissioning testing and initial field tests are scheduled to occur in a 1200

  4. The evaluation of stress and piping support loads on RSG-GAS secondary cooling system

    International Nuclear Information System (INIS)

    Pustandyo, W.; Sitandung, Y. B.; Sujalmo, S.

    1998-01-01

    The evaluation of stress and piping support loads was evaluated on piping segment of secondary cooling water piping. In this paper, the analysis methods are presented with the use of computer code PS + CAEPIPE Version 3. 4. 05. W. From the selected pipe segment, the data of pipe characteristic, material properties, operation and design condition, equipment and support were used as inputs. The result of analysis show that stress and support loads if using location, kind and number of support equal with the system that have been installed for sustain load 3638 psi (node 160), thermal 13517 psi (node 90) and combination of sustain and thermal (node 90) 16747 psi. Meanwhile,if the optimization support, stress and support load for sustain load are respectively 4238 psi (node 10), thermal 13517 psi (node 90) and combination of sustain + thermal (node 90) 17350 psi. The limit values of permitted support based on Code PS+CAEPIPE of sustain load are 15000 psi, thermal 22500 psi and combination of sustain + thermal 37500 psi. The conclusion of evaluation result, that stress support load of pipe secondary cooling system are sufficiently low and using support show excessive and not economic

  5. Cortisol and melatonin in the cutaneous stress response system of fish.

    Science.gov (United States)

    Kulczykowska, Ewa; Kalamarz-Kubiak, Hanna; Gozdowska, Magdalena; Sokołowska, Ewa

    2018-04-01

    The stress hormone cortisol, together with antioxidants, melatonin (Mel) and its biologically active metabolites, 5-methoxykynuramines, including AFMK, set up a local stress response system in mammalian skin. Our in vitro study of the European flounder (Platichthys flesus) was designed to examine whether Mel and AFMK would respond to cortisol while a glucocorticoid is added to the incubation medium. The concentrations of cortisol in the incubation medium mimic plasma cortisol levels seen in fish exposed to different types of stresses such as handling, confinement, high density, food-deprivation or air-exposure. We measured Mel and AFMK in skin explants and culture media using high-performance liquid chromatography (HPLC) with fluorescence detection. We also analysed melanosome response (dispersion/aggregation) in the explants subjected to the different treatments. Cortisol stimulated the release of Mel and AFMK from skin explants in a dose-dependent manner. Melanosome dispersion and a darkening of the skin explants were observed after incubation with cortisol. This study is the first to demonstrate the interrelationship between cortisol and Mel/AFMK in fish skin. Our data strongly suggest that the cutaneous stress response system (CSRS) is present in fish. The question remains whether Mel, AFMK or cortisol are synthetized locally in fish skin and/or transported by the bloodstream. The presence of the CSRS should be taken into account during elaboration of new indicators of fish welfare both in aquaculture and in the wild. Copyright © 2018 Elsevier Inc. All rights reserved.

  6. Effects of stress on gastrointestinal function: interactions of neural and endocrine systems in mediating stress-induced intestinal dysfunction in rats

    International Nuclear Information System (INIS)

    Williams, C.L.

    1987-01-01

    The etiology of stress-induced intestinal dysfunction is completely unresolved, and the lack of an appropriate animal model has hindered studies of causality. We compared a number of stressors and their resultant effects on intestinal transit, a measure of the propulsive motor activity of the gut, in the rat. We found that the response of the intestine to stress, and the neural systems activated by stress, were dependent on the type and duration of stress, as well as the animal strain, and gender. We developed a model, acute wrapping restraint stress, to fully characterize the effects of stress on intestinal transit. Wrap restraint stress is a nonulcerogenic model in which rats are subjected to acute restraint by wrapping them in a harness of paper tape to restrict, but not prevent movement of the upper body and forelimbs. Transit was evaluated by the geometric center method, in which a radiomarker ( 51 Cr) is instilled directly into the proximal duodenum and proximal colon via a surgically placed intestinal cannula, in fasted, adult female Sprague Dawley rats

  7. Construction of an integrated gene regulatory network link to stress-related immune system in cattle.

    Science.gov (United States)

    Behdani, Elham; Bakhtiarizadeh, Mohammad Reza

    2017-10-01

    The immune system is an important biological system that is negatively impacted by stress. This study constructed an integrated regulatory network to enhance our understanding of the regulatory gene network used in the stress-related immune system. Module inference was used to construct modules of co-expressed genes with bovine leukocyte RNA-Seq data. Transcription factors (TFs) were then assigned to these modules using Lemon-Tree algorithms. In addition, the TFs assigned to each module were confirmed using the promoter analysis and protein-protein interactions data. Therefore, our integrated method identified three TFs which include one TF that is previously known to be involved in immune response (MYBL2) and two TFs (E2F8 and FOXS1) that had not been recognized previously and were identified for the first time in this study as novel regulatory candidates in immune response. This study provides valuable insights on the regulatory programs of genes involved in the stress-related immune system.

  8. Multiaxial Cycle Deformation and Low-Cycle Fatigue Behavior of Mild Carbon Steel and Related Welded-Metal Specimen

    Directory of Open Access Journals (Sweden)

    Weilian Qu

    2017-01-01

    Full Text Available The low-cycle fatigue experiments of mild carbon Q235B steel and its related welded-metal specimens are performed under uniaxial, in-phase, and 90° out-of-phase loading conditions. Significant additional cyclic hardening for 90° out-of-phase loading conditions is observed for both base metal and its related weldment. Besides, welding process produces extra additional hardening under the same loading conditions compared with the base metal. Multiaxial low-cycle fatigue strength under 90° out-of-phase loading conditions is significantly reduced for both base-metal and welded-metal specimens. The weldment has lower fatigue life than the base metal under the given loading conditions, and the fatigue life reduction of weldment increases with the increasing strain amplitude. The KBM, FS, and MKBM critical plane parameters are evaluated for the fatigue data obtained. The FS and MKBM parameters are found to show better correlation with fatigue lives for both base-metal and welded-metal specimens.

  9. Inertia coupling analysis of a self-decoupled wheel force transducer under multi-axis acceleration fields.

    Directory of Open Access Journals (Sweden)

    Lihang Feng

    Full Text Available Wheel force transducer (WFT, which measures the three-axis forces and three-axis torques applied to the wheel, is an important instrument in the vehicle testing field and has been extremely promoted by researchers with great interests. The transducer, however, is typically mounted on the wheel of a moving vehicle, especially on a high speed car, when abruptly accelerating or braking, the mass/inertia of the transducer/wheel itself will have an extra effect on the sensor response so that the inertia/mass loads will also be detected and coupled into the signal outputs. The effect which is considered to be inertia coupling problem will decrease the sensor accuracy. In this paper, the inertia coupling of a universal WFT under multi-axis accelerations is investigated. According to the self-decoupling approach of the WFT, inertia load distribution is solved based on the principle of equivalent mass and rotary inertia, thus then inertia impact can be identified with the theoretical derivation. The verification is achieved by FEM simulation and experimental tests. Results show that strains in simulation agree well with the theoretical derivation. The relationship between the applied acceleration and inertia load for both wheel force and moment is the approximate linear, respectively. All the relative errors are less than 5% which are within acceptable and the inertia loads have the maximum impact on the signal output about 1.5% in the measurement range.

  10. Inertia coupling analysis of a self-decoupled wheel force transducer under multi-axis acceleration fields.

    Science.gov (United States)

    Feng, Lihang; Lin, Guoyu; Zhang, Weigong; Dai, Dong

    2015-01-01

    Wheel force transducer (WFT), which measures the three-axis forces and three-axis torques applied to the wheel, is an important instrument in the vehicle testing field and has been extremely promoted by researchers with great interests. The transducer, however, is typically mounted on the wheel of a moving vehicle, especially on a high speed car, when abruptly accelerating or braking, the mass/inertia of the transducer/wheel itself will have an extra effect on the sensor response so that the inertia/mass loads will also be detected and coupled into the signal outputs. The effect which is considered to be inertia coupling problem will decrease the sensor accuracy. In this paper, the inertia coupling of a universal WFT under multi-axis accelerations is investigated. According to the self-decoupling approach of the WFT, inertia load distribution is solved based on the principle of equivalent mass and rotary inertia, thus then inertia impact can be identified with the theoretical derivation. The verification is achieved by FEM simulation and experimental tests. Results show that strains in simulation agree well with the theoretical derivation. The relationship between the applied acceleration and inertia load for both wheel force and moment is the approximate linear, respectively. All the relative errors are less than 5% which are within acceptable and the inertia loads have the maximum impact on the signal output about 1.5% in the measurement range.

  11. Evaluation and summary of a study of the long-term multiaxial creep behavior of concrete

    International Nuclear Information System (INIS)

    Kennedy, T.W.

    1975-12-01

    The creep behavior of concrete subjected to triaxial compressive stresses and elevated temperature was evaluated. Strains were measured in cylindrical specimens subjected to 58 test conditions: 0--3600 psi compressions; curing times of 90, 183, and 365 days; two curing histories (air-dried and as-cast); and two temperatures (75 and 150 0 F). The 90-day-cwed specimens were loaded for 12 months, followed by 5-month recovery. The other specimens were uniaxially stressed to 600 or 2400 psi for 5.25 or 4.75 years at 75 0 F, followed by 77-day recovery. Strain measurements were made during the curing, loaded, and unloaded-recovery periods. This report describes the experiment setup and summarizes the results and recommendations

  12. Systemic inflammatory changes and increased oxidative stress in rural Indian women cooking with biomass fuels

    International Nuclear Information System (INIS)

    Dutta, Anindita; Ray, Manas Ranjan; Banerjee, Anirban

    2012-01-01

    The study was undertaken to investigate whether regular cooking with biomass aggravates systemic inflammation and oxidative stress that might result in increase in the risk of developing cardiovascular disease (CVD) in rural Indian women compared to cooking with a cleaner fuel like liquefied petroleum gas (LPG). A total of 635 women (median age 36 years) who cooked with biomass and 452 age-matched control women who cooked with LPG were enrolled. Serum interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-8 (IL-8) were measured by ELISA. Generation of reactive oxygen species (ROS) by leukocytes was measured by flow cytometry, and erythrocytic superoxide dismutase (SOD) was measured by spectrophotometry. Hypertension was diagnosed following the Seventh Report of the Joint Committee. Tachycardia was determined as pulse rate > 100 beats per minute. Particulate matter of diameter less than 10 and 2.5 μm (PM 10 and PM 2.5 , respectively) in cooking areas was measured using real-time aerosol monitor. Compared with control, biomass users had more particulate pollution in indoor air, their serum contained significantly elevated levels of IL-6, IL-8, TNF-α and CRP, and ROS generation was increased by 37% while SOD was depleted by 41.5%, greater prevalence of hypertension and tachycardia compared to their LPG-using neighbors. PM 10 and PM 2.5 levels were positively associated with markers of inflammation, oxidative stress and hypertension. Inflammatory markers correlated with raised blood pressure. Cooking with biomass exacerbates systemic inflammation, oxidative stress, hypertension and tachycardia in poor women cooking with biomass fuel and hence, predisposes them to increased risk of CVD development compared to the controls. Systemic inflammation and oxidative stress may be the mechanistic factors involved in the development of CVD. -- Highlights: ► Effect of chronic biomass smoke exposure on cardiovascular health was

  13. Finnish physicians' stress related to information systems keeps increasing: a longitudinal three-wave survey study.

    Science.gov (United States)

    Heponiemi, Tarja; Hyppönen, Hannele; Vehko, Tuulikki; Kujala, Sari; Aalto, Anna-Mari; Vänskä, Jukka; Elovainio, Marko

    2017-10-17

    Poorly functioning, time-consuming, and inadequate information systems are among the most important work-related psychosocial factors causing stress in physicians. The present study examined the trend in the perceived stress that was related to information systems (SRIS) among Finnish physicians during a nine-year follow-up. In addition, we examined the associations of gender, age, employment sector, specialization status, leadership position, on-call burden, and time pressure with SRIS change and levels. A longitudinal design with three survey data collection waves (2006, 2010 and 2015) based on a random sample of Finnish physicians in 2006 was used. The study sample included 1095 physicians (62.3% women, mean age 54.4 years) who provided data on SRIS in every wave. GLM repeated measures analyses were used to examine the associations between independent variables and the SRIS trend during the years 2006, 2010, and 2015. SRIS increased during the study period. The estimated marginal mean of SRIS in 2006 was 2.80 (95% CI = 2.68-2.92) and the mean increase was 0.46 (95% CI = 0.30-0.61) points from 2006 to 2010 and 0.25 (95% CI = 0.11-0.39) points from 2010 to 2015. Moreover, our results show that the increase was most pronounced in primary care, whereas in hospitals SRIS did not increase between 2010 and 2015. SRIS increased more among those in a leadership position. On-call duties and high time-pressures were associated with higher SRIS levels during all waves. Changing, difficult, and poorly functioning information systems (IS) are a prominent source of stress among Finnish physicians and this perceived stress continues to increase. Organizations should implement arrangements to ease stress stemming from IS especially for those with a high workload and on-call or leadership duties. To decrease IS-related stress, it would be important to study in more detail the main IS factors that contribute to SRIS. Earlier studies indicate that the usability and stability

  14. Systemic inflammatory changes and increased oxidative stress in rural Indian women cooking with biomass fuels

    Energy Technology Data Exchange (ETDEWEB)

    Dutta, Anindita, E-mail: anidu14@gmail.com [College of Environmental Sciences and Engineering, Peking University, Beijing (China); Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata-700 026 (India); Ray, Manas Ranjan; Banerjee, Anirban [Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata-700 026 (India)

    2012-06-15

    The study was undertaken to investigate whether regular cooking with biomass aggravates systemic inflammation and oxidative stress that might result in increase in the risk of developing cardiovascular disease (CVD) in rural Indian women compared to cooking with a cleaner fuel like liquefied petroleum gas (LPG). A total of 635 women (median age 36 years) who cooked with biomass and 452 age-matched control women who cooked with LPG were enrolled. Serum interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-8 (IL-8) were measured by ELISA. Generation of reactive oxygen species (ROS) by leukocytes was measured by flow cytometry, and erythrocytic superoxide dismutase (SOD) was measured by spectrophotometry. Hypertension was diagnosed following the Seventh Report of the Joint Committee. Tachycardia was determined as pulse rate > 100 beats per minute. Particulate matter of diameter less than 10 and 2.5 μm (PM{sub 10} and PM{sub 2.5}, respectively) in cooking areas was measured using real-time aerosol monitor. Compared with control, biomass users had more particulate pollution in indoor air, their serum contained significantly elevated levels of IL-6, IL-8, TNF-α and CRP, and ROS generation was increased by 37% while SOD was depleted by 41.5%, greater prevalence of hypertension and tachycardia compared to their LPG-using neighbors. PM{sub 10} and PM{sub 2.5} levels were positively associated with markers of inflammation, oxidative stress and hypertension. Inflammatory markers correlated with raised blood pressure. Cooking with biomass exacerbates systemic inflammation, oxidative stress, hypertension and tachycardia in poor women cooking with biomass fuel and hence, predisposes them to increased risk of CVD development compared to the controls. Systemic inflammation and oxidative stress may be the mechanistic factors involved in the development of CVD. -- Highlights: ► Effect of chronic biomass smoke exposure on

  15. Response of antioxidant system to drought stress and re-watering in Alfalfa during branching

    Science.gov (United States)

    Tina, R. R.; Shan, X. R.; Wang, Y.; Guo, S. Y.; Mao, B.; Wang, W.; Wu, H. Y.; Zhao, T. H.

    2017-11-01

    This paper aimed to reveal the response mechanism of active oxygen metabolism and antioxidant enzyme activities in Alfalfa under drought stress and re-watering, and the pot experiment was used, to explore the changes of H2O2, O2·-, electrolyte leakage conductivity and MDA, SOD, POD, CAT activity in Golden Empress (tolerant cultivar) and Sanditi (non-tolerant cultivar) under drought stress and re-watering during branching stage. Three water gradients were set up: CK (Maximum field capacity of 75%±5%), T1 (Maximum field capacity of 45%±5%), T2 (Maximum field capacity of 35%±5%) to compare, and the drought rehydration was also studied. Results: the results indicated that H2O2 content, O2·-production rate, relative conductivity and MDA content were higher than the control, and the increase extent of Golden Empress was higher than the Sanditi under drought stress and after re-watering the recovery capability of Golden Empress was also higher than the Sanditi. After 7 days of re-watering, all indexes were restored to the control level, indicating that the re-watering have compensation effect after drought. After drought stress, to weaken the damage of active oxygen Golden Empress was mainly by increasing the activity of POD and SOD, but Sanditi was mainly through the POD and CAT activity increased to effectively remove ROS. Under drought stress, active oxygen in leaves of Alfalfa increased, and thus the membrane system was damaged which lead to the increase of MDA content and relative electric conductivity. Plants play a defensive role by increasing the activity of antioxidant enzymes and scavenging reactive oxygen species. After re-watering, the stress effect was reduced, and the physiological indexes of plants were restored to the control level. In general, tolerant cultivar has stronger antioxidant properties under drought and re-watering.

  16. Stresses and residual stresses optical measurements systems evaluation; Avaliacao de sistemas opticos de medicao de tensoes e tensoes residuais em dutos

    Energy Technology Data Exchange (ETDEWEB)

    Peixoto Filho, Flavio Tito; Goncalves Junior, Armando Albertazzi [Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC (Brazil). Lab. de Metrologia e Automatizacao (LABMETRO)

    2004-07-01

    There is always a constant concern about the pipelines' integrity. An important control parameter is the level of total mechanical stresses acting over the pipeline. However, the loading and residual stresses acting on a pipeline are not measured in the field as much as necessary. Technical difficulties and the high cost of the nowadays techniques and the hostile measurement conditions are the main reason for that. An alternative method has been developed at the Universidade Federal de Santa Catarina (UFSC) since 1992. A new optical measurement device is used to measure strains, mechanical stresses and residual stresses acting over the structure. A metrological and functional evaluation of this system is the main focus of this paper. (author)

  17. Physiological antioxidant system and oxidative stress in stomach cancer patients with normal renal and hepatic function

    Directory of Open Access Journals (Sweden)

    E Prabhakar Reddy

    2010-04-01

    Full Text Available Role of free radicals has been proposed in the pathogenesis of many diseases. Gastric cancer is a common disease worldwide, and leading cause of cancer death in India. Severe oxidative stress produces reactive oxygen species (ROS and induces uncontrolled lipid peroxidation. Albumin, uric acid (UA and Bilirubin are important physiological antioxidants. We aimed to evaluate and assess the role of oxidative stress (OS and physiological antioxidant system in stomach cancer patients. Lipid peroxidation measured as plasma Thio Barbituric Acid Reactive substances (TBARS, was found to be elevated significantly (p=0.001 in stomach cancer compared to controls along with a decrease in plasma physiological antioxidant system. The documented results were due to increased lipid peroxidation and involvement of physiological antioxidants in scavenging free radicals but not because of impaired hepatic and renal functions.

  18. Stress Corrosion Evaluation of Nitinol 60 for the International Space Station Water Recycling System

    Science.gov (United States)

    Torres, P. D.

    2016-01-01

    A stress corrosion cracking (SCC) evaluation of Nitinol 60 was performed because this alloy is considered a candidate bearing material for the Environmental Control and Life Support System (ECLSS), specifically in the Urine Processing Assembly of the International Space Station. An SCC evaluation that preceded this one during the 2013-2014 timeframe included various alloys: Inconel 625, Hastelloy C-276, titanium (Ti) commercially pure (CP), Ti 6Al-4V, extra-low interstitial (ELI) Ti 6Al-4V, and Cronidur 30. In that evaluation, most specimens were exposed for a year. The results of that evaluation were published in NASA/TM-2015-218206, entitled "Stress Corrosion Evaluation of Various Metallic Materials for the International Space Station Water Recycling System,"1 available at the NASA Scientific and Technical Information program web page: http://www.sti.nasa.gov. Nitinol 60 was added to the test program in 2014.

  19. How sulphate-reducing microorganisms cope with stress: Lessons from systems biology

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, J.; He, Q.; Hemme, C.L.; Mukhopadhyay, A.; Hillesland, K.; Zhou, A.; He, Z.; Nostrand, J.D. Van; Hazen, T.C.; Stahl, D.A.; Wall, J.D.; Arkin, A.P.

    2011-04-01

    Sulphate-reducing microorganisms (SRMs) are a phylogenetically diverse group of anaerobes encompassing distinct physiologies with a broad ecological distribution. As SRMs have important roles in the biogeochemical cycling of carbon, nitrogen, sulphur and various metals, an understanding of how these organisms respond to environmental stresses is of fundamental and practical importance. In this Review, we highlight recent applications of systems biology tools in studying the stress responses of SRMs, particularly Desulfovibrio spp., at the cell, population, community and ecosystem levels. The syntrophic lifestyle of SRMs is also discussed, with a focus on system-level analyses of adaptive mechanisms. Such information is important for understanding the microbiology of the global sulphur cycle and for developing biotechnological applications of SRMs for environmental remediation, energy production, biocorrosion control, wastewater treatment and mineral recovery.

  20. The Impact of Performance Appraisal, Reward System, Job Stress, and Work Life Conflict to Employee Performance

    OpenAIRE

    Rumambie, Yuliana Fransisca

    2014-01-01

    Employee Performance is an important part in a company or organization. It plays a very important role in an organization because performance of the company or organization largely depends on the performance of its employee. Recently, organizations realize that there are several factors that can affect employee performance. Several factors that can considered as the major determinants of employee performance, such as Performance Appraisal, Reward System, Job Stress, and Work life conflict. Th...

  1. Anharmonic vibrational properties in periodic systems: energy, electron-phonon coupling, and stress

    OpenAIRE

    Monserrat, Bartomeu; Drummond, N. D.; Needs, R. J.

    2013-01-01

    A unified approach is used to study vibrational properties of periodic systems with first-principles methods and including anharmonic effects. Our approach provides a theoretical basis for the determination of phonon-dependent quantities at finite temperatures. The low-energy portion of the Born-Oppenheimer energy surface is mapped and used to calculate the total vibrational energy including anharmonic effects, electron-phonon coupling, and the vibrational contribution to the stress tensor. W...

  2. The effect of performance-based pay systems on job satisfaction and stress

    OpenAIRE

    Hornbach, Jessica Janina

    2013-01-01

    Previous investigations regarding the health- and wellbeing-related outcomes of performance-based pay systems have been scarce and ambiguous so far. Considering the huge economic and organizational impact of stress-related health problems, it is important to further investigate this relation, including the impact of different variables that can help to explain the variation in the relationship between performance-based pay and job strain. The main purpose of this study is to challenge the res...

  3. Motion and Stress Analysis of Cam System for Marine Diesel Engine 93 KW

    Directory of Open Access Journals (Sweden)

    Christian Dhani Setiawan

    2017-01-01

    Full Text Available The developments of maritime sector in Indonesia shows increasing demand for ships. Especially ships with size of 30 GT has problem with low availability of the ship engine, which most of the ships still use non marine diesel engine as its main propulsion. The problem gives interest to make a step to improve by design marine diesel engine using reverse engineering method. Cam system of marine diesel engine design was needed to be calculate to select the material and the motion. The design of cam system needs study about the stress analysis in cam system to make sure the distribution of force and moment. The result of stress analysis was used to select material of components in cam system. The motion analysis result was used to be input data of stress analysis. The condition to obtain the stress of components was on maximum condition, its contain pressure, torque, rotation, and force. All component that calculated are camshaft, lifter (flat-tappet, push rod, rocker arm, spring, and valve. Each component was given two different materials and material selection was based on safety factor of each component. Material for camshaft and lifter were malleable cast iron, for push rod and rocker arm were mild steel, for spring was ASTM A231, for intake valve was steel JIS SUH3, and for exhaust valve was steel JIS SUH35. The result of motion analysis were angular velocity of camshaft with value was 2400 deg/sec, friction force between camshaft and lifter with maximum value was 125.393 N, and contact force between camshaft and lifter with maximum value was 845.307 N, and linear velocity of intake valve with maximum value was 696.573 mm/s, and linear velocity of exhaust valve was 463.734 mm/s.

  4. Stress and addiction: contribution of the corticotropin releasing factor (CRF system in neuroplasticity

    Directory of Open Access Journals (Sweden)

    Carolina L Haass-Koffler

    2012-09-01

    Full Text Available Corticotropin releasing factor (CRF has been shown to induce various behavioral changes related to adaptation to stress. Dysregulation of the CRF system at any point can lead to a variety of psychiatric disorders, including substance use disorders (SUDs. CRF has been associated with stress-induced drug reinforcement. Extensive literature has identified CRF to play an important role in the molecular mechanisms that lead to an increase in susceptibility that precipitates relapse to SUDs. The CRF system has a heterogeneous role in SUDs. It enhances the acute effects of drugs of abuse and is also responsible for the potentiation of drug-induced neuroplasticity evoked during the withdrawal period. We present in this review the brain regions and circuitries where CRF is expressed and may participate in stress-induced drug abuse. Finally, we attempt to evaluate the role of modulating the CRF system as a possible therapeutic strategy for treating the dysregulation of emotional behaviors that result from the acute positive reinforcement of substances of abuse as well as the negative reinforcement produced by withdrawal.

  5. Role of the Orexin/Hypocretin System in Stress-Related Psychiatric Disorders.

    Science.gov (United States)

    James, Morgan H; Campbell, Erin J; Dayas, Christopher V

    2017-01-01

    Orexins (hypocretins) are critically involved in coordinating appropriate physiological and behavioral responses to aversive and threatening stimuli. Acute stressors engage orexin neurons via direct projections from stress-sensitive brain regions. Orexin neurons, in turn, facilitate adaptive behavior via reciprocal connections as well as via direct projections to the hypophysiotropic neurons that coordinate the hypothalamic-pituitary-adrenal (HPA) axis response to stress. Consequently, hyperactivity of the orexin system is associated with increased motivated arousal and anxiety, and is emerging as a key feature of panic disorder. Accordingly, there has been significant interest in the therapeutic potential of pharmacological agents that antagonize orexin signaling at their receptors for the treatment of anxiety disorders. In contrast, disorders characterized by inappropriately low levels of motivated arousal, such as depression, generally appear to be associated with hypoactivity of the orexin system. This includes narcolepsy with cataplexy, a disorder characterized by the progressive loss of orexin neurons and increased rates of moderate/severe depression symptomology. Here, we provide a comprehensive overview of both clinical and preclinical evidence highlighting the role of orexin signaling in stress reactivity, as well as how perturbations to this system can result in dysregulated behavioral phenotypes.

  6. [Characteristics of the sympathoadrenal system response to psychoemotional stress under hypoxic conditions in aged people with physiological and accelerated aging of the respiratory system].

    Science.gov (United States)

    Asanov, E O; Os'mak, Ie D; Kuz'mins'ka, L A

    2013-01-01

    The peculiarities of the response of the sympathoadrenal system to psychoemotional and hypoxic stress in healthy young people and in aged people with physiological and accelerated aging of respiratory system were studied. It was shown that in aging a more pronounced response of the sympathoadrenal system to psychoemotional stress. At the same time, elderly people with different types of aging of the respiratory system did not demonstrate a difference in the response of the sympathoadrenal system to psychoemotional stress. Unlike in young people, in aged people, combination of psychoemotional and hypoxic stresses resulted in further activation of the sympathoadrenal system. The reaction of the sympathoadrenal system was more expressed in elderly people with accelerated ageing of the respiratory system.

  7. Conceptualizing the dynamics of workplace stress: a systems-based study of nursing aides.

    Science.gov (United States)

    Jetha, Arif; Kernan, Laura; Kurowski, Alicia

    2017-01-05

    Workplace stress is a complex phenomenon that may often be dynamic and evolving over time. Traditional linear modeling does not allow representation of recursive feedback loops among the implicated factors. The objective of this study was to develop a multidimensional system dynamics model (SDM) of workplace stress among nursing aides and conduct simulations to illustrate how changes in psychosocial perceptions and workplace factors might influence workplace stress over time. Eight key informants with prior experience in a large study of US nursing home workers participated in model building. Participants brainstormed the range of components related to workplace stress. Components were grouped together based on common themes and translated into feedback loops. The SDM was parameterized through key informant insight on the shape and magnitude of the relationship between model components. Model construction was also supported utilizing survey data collected as part of the larger study. All data was entered into the software program, Vensim. Simulations were conducted to examine how adaptations to model components would influence workplace stress. The SDM included perceptions of organizational conditions (e.g., job demands and job control), workplace social support (i.e., managerial and coworker social support), workplace safety, and demands outside of work (i.e. work-family conflict). Each component was part of a reinforcing feedback loop. Simulations exhibited that scenarios with increasing job control and decreasing job demands led to a decline in workplace stress. Within the context of the system, the effects of workplace social support, workplace safety, and work-family conflict were relatively minor. SDM methodology offers a unique perspective for researchers and practitioners to view workplace stress as a dynamic process. The portrayal of multiple recursive feedback loops can guide the development of policies and programs within complex organizational contexts

  8. Apelin-APJ system is responsible for stress-induced increase in atrial natriuretic peptide expression in rat heart.

    Science.gov (United States)

    Izgut-Uysal, Vecihe Nimet; Acar, Nuray; Birsen, Ilknur; Ozcan, Filiz; Ozbey, Ozlem; Soylu, Hakan; Avci, Sema; Tepekoy, Filiz; Akkoyunlu, Gokhan; Yucel, Gultekin; Ustunel, Ismail

    2018-04-01

    The cardiovascular system is a primary target of stress and stress is the most important etiologic factor in cardiovascular diseases. Stressors increase expressions of atrial natriuretic peptide (ANP) and apelin in cardiac tissue. The aim of the present study was to investigate whether stress-induced apelin has an effect on the expression of ANP in the right atrium of rat heart. The rats were divided into the control, stress and F13A+stress groups. In the stress and F13A+stress groups, the rats were subjected to water immersion and restraint stress (WIRS) for 6h. In the F13A+stress group, apelin receptor antagonist F13A, was injected intravenously immediately before application of WIRS. The plasma samples were obtained for the measurement of corticosterone and atrial natriuretic peptide. The atrial samples were used for immunohistochemistry and western blot analysis. F13A administration prevented the rise of plasma corticosterone and ANP levels induced by WIRS. While WIRS application increased the expressions of apelin, HIF-1α and ANP in atrial tissue, while F13A prevented the stress-induced increase in the expression of HIF-1α and ANP. Stress-induced apelin induces ANP expression in atrial tissue and may play a role in cardiovascular homeostasis by increasing ANP expression under WIRS conditions. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in an Animal Model of Gulf War Illness

    Science.gov (United States)

    Shetty, Geetha A.; Hattiangady, Bharathi; Upadhya, Dinesh; Bates, Adrian; Attaluri, Sahithi; Shuai, Bing; Kodali, Maheedhar; Shetty, Ashok K.

    2017-01-01

    Memory and mood dysfunction are the key symptoms of Gulf war illness (GWI), a lingering multi-symptom ailment afflicting >200,000 veterans who served in the Persian Gulf War-1. Research probing the source of the disease has demonstrated that concomitant exposures to anti-nerve gas agent pyridostigmine bromide (PB), pesticides, and war-related stress are among the chief causes of GWI. Indeed, exposures to GWI-related chemicals (GWIR-Cs) and mild stress in animal models cause memory and mood impairments alongside reduced neurogenesis and chronic low-level inflammation in the hippocampus. In the current study, we examined whether exposure to GWIR-Cs and stress causes chronic changes in the expression of genes related to increased oxidative stress, mitochondrial dysfunction, and inflammation in the hippocampus. We also investigated whether GWI is linked with chronically increased activation of Nrf2 (a master regulator of antioxidant response) in the hippocampus, and inflammation and enhanced oxidative stress at the systemic level. Adult male rats were exposed daily to low-doses of PB and pesticides (DEET and permethrin), in combination with 5 min of restraint stress for 4 weeks. Analysis of the hippocampus performed 6 months after the exposure revealed increased expression of many genes related to oxidative stress response and/or antioxidant activity (Hmox1, Sepp1, and Srxn1), reactive oxygen species metabolism (Fmo2, Sod2, and Ucp2) and oxygen transport (Ift172 and Slc38a1). Furthermore, multiple genes relevant to mitochondrial respiration (Atp6a1, Cox6a1, Cox7a2L, Ndufs7, Ndufv1, Lhpp, Slc25a10, and Ucp1) and neuroinflammation (Nfkb1, Bcl6, Csf2, IL6, Mapk1, Mapk3, Ngf, N-pac, and Prkaca) were up-regulated, alongside 73–88% reduction in the expression of anti-inflammatory genes IL4 and IL10, and nuclear translocation and increased expression of Nrf2 protein. These hippocampal changes were associated with elevated levels of pro-inflammatory cytokines and chemokines

  10. Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in an Animal Model of Gulf War Illness.

    Science.gov (United States)

    Shetty, Geetha A; Hattiangady, Bharathi; Upadhya, Dinesh; Bates, Adrian; Attaluri, Sahithi; Shuai, Bing; Kodali, Maheedhar; Shetty, Ashok K

    2017-01-01

    Memory and mood dysfunction are the key symptoms of Gulf war illness (GWI), a lingering multi-symptom ailment afflicting >200,000 veterans who served in the Persian Gulf War-1. Research probing the source of the disease has demonstrated that concomitant exposures to anti-nerve gas agent pyridostigmine bromide (PB), pesticides, and war-related stress are among the chief causes of GWI. Indeed, exposures to GWI-related chemicals (GWIR-Cs) and mild stress in animal models cause memory and mood impairments alongside reduced neurogenesis and chronic low-level inflammation in the hippocampus. In the current study, we examined whether exposure to GWIR-Cs and stress causes chronic changes in the expression of genes related to increased oxidative stress, mitochondrial dysfunction, and inflammation in the hippocampus. We also investigated whether GWI is linked with chronically increased activation of Nrf2 (a master regulator of antioxidant response) in the hippocampus, and inflammation and enhanced oxidative stress at the systemic level. Adult male rats were exposed daily to low-doses of PB and pesticides (DEET and permethrin), in combination with 5 min of restraint stress for 4 weeks. Analysis of the hippocampus performed 6 months after the exposure revealed increased expression of many genes related to oxidative stress response and/or antioxidant activity ( Hmox1, Sepp1 , and Srxn1 ), reactive oxygen species metabolism ( Fmo2, Sod2 , and Ucp2 ) and oxygen transport ( Ift172 and Slc38a1 ). Furthermore, multiple genes relevant to mitochondrial respiration ( Atp6a1, Cox6a1, Cox7a2L, Ndufs7, Ndufv1, Lhpp, Slc25a10 , and Ucp1 ) and neuroinflammation ( Nfkb1, Bcl6, Csf2, IL6, Mapk1, Mapk3, Ngf, N-pac , and Prkaca ) were up-regulated, alongside 73-88% reduction in the expression of anti-inflammatory genes IL4 and IL10 , and nuclear translocation and increased expression of Nrf2 protein. These hippocampal changes were associated with elevated levels of pro-inflammatory cytokines

  11. Stress and Welfare of African Catfish (Clarias gariepinus Burchell, 1822 in a Coupled Aquaponic System

    Directory of Open Access Journals (Sweden)

    Björn Baßmann

    2017-07-01

    Full Text Available African catfish (Clarias gariepinus were investigated for physiological stress parameters to assess the influence of different cultivation techniques on fish welfare. The fish were reared in two conceptually identical recirculating aquaculture systems (RAS constructed in a greenhouse. One system was combined with a floating raft hydroponic unit to culture cucumbers (Cucumis sativus only using the process water. The second system remained without the plant cultivation unit and functioned as the control. Water quality was monitored regularly by measuring dissolved nutrients and physical water parameters. During 87 days, a total of 71 fish from each system (n = 142 were studied, with a final sampling of all fish (n = 107 at the end of the experiment. Blood from the caudal vein was analyzed for the stress hormone cortisol and the glucose concentration. In addition, fish were investigated for external injuries on their skin, fins and barbels. The results demonstrate that the system design had no influence on fish mortalities and growth rates. Furthermore, cortisol and blood glucose levels did not differ significantly between the two systems. However, the number of external injuries was significantly lower in the aquaponics, providing evidence that co-cultivation of fish and plants might offer benefits to the welfare of the fish.

  12. PSA-2, Stress Analysis, Thermal Expansion and Loads in Multi Anchor Piping System

    Energy Technology Data Exchange (ETDEWEB)

    Nickols, A N [Codes Coordinator, Atomics International, P. O. Box 309, Canoga Park, California 91304 (United States)

    1975-03-01

    1 - Description of problem or function: PSA2 computes the reactions and stresses caused by thermal expansion and loads in a multi-anchor piping system which may contain loops and may be partially restrained at any point in any direction. 2 - Method of solution: The linear equations for the statically indeterminate pipe system are set up by a generalization of Brock's matrix method. By a systematic use of linear transforms, the matrix of the system of linear equations can be obtained by incidence algebra in the form of a symmetric banded matrix. 2 - Restrictions on the complexity of the problem - Maximum of: 36 sections. 3 - Unusual features of the program - PSA2 takes into account: (a) elasticity of the attachment of the pipe to the foundation, (b) restraints on pipe displacements by anchors and intermediate partial constraints of linear type, (c) given constant forces and moments acting upon the pipe system, (d) thermal expansion, (e) any geometrical structure of the pipe system, (f) several cases of stressing per pipe system, and (g) both metric and English units.

  13. The oxidative stress-inducible cystine/glutamate antiporter, system x (c) (-) : cystine supplier and beyond.

    Science.gov (United States)

    Conrad, Marcus; Sato, Hideyo

    2012-01-01

    The oxidative stress-inducible cystine/glutamate exchange system, system x (c) (-) , transports one molecule of cystine, the oxidized form of cysteine, into cells and thereby releases one molecule of glutamate into the extracellular space. It consists of two protein components, the 4F2 heavy chain, necessary for membrane location of the heterodimer, and the xCT protein, responsible for transport activity. Previously, system x (c) (-) has been regarded to be a mere supplier of cysteine to cells for the synthesis of proteins and the antioxidant glutathione (GSH). In that sense, oxygen, electrophilic agents, and bacterial lipopolysaccharide trigger xCT expression to accommodate with increased oxidative stress by stimulating GSH biosynthesis. However, emerging evidence established that system x (c) (-) may act on its own as a GSH-independent redox system by sustaining a redox cycle over the plasma membrane. Hallmarks of this cycle are cystine uptake, intracellular reduction to cysteine and secretion of the surplus of cysteine into the extracellular space. Consequently, increased levels of extracellular cysteine provide a reducing microenvironment required for proper cell signaling and communication, e.g. as already shown for the mechanism of T cell activation. By contrast, the enhanced release of glutamate in exchange with cystine may trigger neurodegeneration due to glutamate-induced cytotoxic processes. This review aims to provide a comprehensive picture from the early days of system x (c) (-) research up to now.

  14. Reconstructive surgery for male stress urinary incontinence: Experiences using the ATOMS system at a single center

    Directory of Open Access Journals (Sweden)

    Krause, Jens

    2014-12-01

    Full Text Available Objective: To propose possible success-driven solutions for problem and complication rates encountered with the ATOMS sling system, based on first-hand experience; and to provide possible actual alternative scenarios for the treatment of male . Patients and methods: During the defined period (between 4/2010 and 04/2014, 36 patients received ATOMS system implants at our clinic. We collected pre- and post-operative evaluation data using the International Consultation on Incontinence Questionnaire Short Form (ICIQ SF. As an expansion of the questionnaire, we added questions about post-operative perineal pain, the general satisfaction with the results of the intervention and willingness to recommend the operation to a best friend. Results: Our data shows a relatively high explantation rate, but a surprisingly high patient satisfaction rate. Explantation was required mainly due to late onset infections or other symptomatic factors. Compared to other studies early onset infections were rare. Conclusion: A non-invasive, uncomplicated adjustable system to alleviate male stress urinary incontinence remains a challenge. Although there are various systems available for the treatment of male stress urinary incontinence, it seems that despite the advantages of the ATOMS system, an artificial sphincter system may pose more advantages based on our experience, understanding and knowledge of its well-documented long-term solutions and problems.

  15. PSA-2, Stress Analysis, Thermal Expansion and Loads in Multi Anchor Piping System

    International Nuclear Information System (INIS)

    Nickols, A.N.

    1975-01-01

    1 - Description of problem or function: PSA2 computes the reactions and stresses caused by thermal expansion and loads in a multi-anchor piping system which may contain loops and may be partially restrained at any point in any direction. 2 - Method of solution: The linear equations for the statically indeterminate pipe system are set up by a generalization of Brock's matrix method. By a systematic use of linear transforms, the matrix of the system of linear equations can be obtained by incidence algebra in the form of a symmetric banded matrix. 2 - Restrictions on the complexity of the problem - Maximum of: 36 sections. 3 - Unusual features of the program - PSA2 takes into account: (a) elasticity of the attachment of the pipe to the foundation, (b) restraints on pipe displacements by anchors and intermediate partial constraints of linear type, (c) given constant forces and moments acting upon the pipe system, (d) thermal expansion, (e) any geometrical structure of the pipe system, (f) several cases of stressing per pipe system, and (g) both metric and English units

  16. Event-related stresses in energy systems and their effects on energy security

    International Nuclear Information System (INIS)

    Hughes, Larry; Ranjan, Ashish

    2013-01-01

    Energy systems change over time as events, such as grid failures, new energy sources, and extreme weather conditions, occur, often affecting the system's energy security. Understanding events, their causes, and how they are handled, can help a jurisdiction and its energy stakeholders develop better, evidence-based energy policy. This paper employs a definition of stress in combination with systems analysis to specify methods for explaining the states through which an energy process, chain, or system passes in response to an event and how this response results in energy security improving, deteriorating, or being maintained. The definition uses three dimensions-availability, affordability, and acceptability-derived from the International Energy Agency's definition of energy security to show when and how a system's energy security will change. Examples are used to illustrate the application of the methods. - Highlights: • A generic set of methods and a common terminology to formalize the ongoing energy security discourse is proposed. • The methods define, measure and explain how energy security can change when events cause stresses in an energy system. • Events are classified in terms of three dimensions derived from the IEA's definition of energy security. • The application of the method is illustrated with detailed examples

  17. Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Wenqing; Zhang, Baoxin; Duan, Dongzhu [State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000 (China); Wu, Jincai [College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000 (China); Fang, Jianguo, E-mail: fangjg@lzu.edu.cn [State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000 (China); College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000 (China)

    2012-08-01

    The thioredoxin system, composed of thioredoxin reductase (TrxR), thioredoxin (Trx), and NADPH, is ubiquitous in all cells and involved in many redox-dependent signaling pathways. Curcumin, a naturally occurring pigment that gives a specific yellow color in curry food, is consumed in normal diet up to 100 mg per day. This molecule has also been used in traditional medicine for the treatment of a variety of diseases. Curcumin has numerous biological functions, and many of these functions are related to induction of oxidative stress. However, how curcumin elicits oxidative stress in cells is unclear. Our previous work has demonstrated the way by which curcumin interacts with recombinant TrxR1 and alters the antioxidant enzyme into a reactive oxygen species (ROS) generator in vitro. Herein we reported that curcumin can target the cytosolic/nuclear thioredoxin system to eventually elevate oxidative stress in HeLa cells. Curcumin-modified TrxR1 dose-dependently and quantitatively transfers electrons from NADPH to oxygen with the production of ROS. Also, curcumin can drastically down-regulate Trx1 protein level as well as its enzyme activity in HeLa cells, which in turn remarkably decreases intracellular free thiols, shifting the intracellular redox balance to a more oxidative state, and subsequently induces DNA oxidative damage. Furthermore, curcumin-pretreated HeLa cells are more sensitive to oxidative stress. Knockdown of TrxR1 sensitizes HeLa cells to curcumin cytotoxicity, highlighting the physiological significance of targeting TrxR1 by curcumin. Taken together, our data disclose a previously unrecognized prooxidant mechanism of curcumin in cells, and provide a deep insight in understanding how curcumin works in vivo. -- Highlights: ► Curcumin induces oxidative stress by targeting the thioredoxin system. ► Curcumin-modified TrxR quantitatively oxidizes NADPH to generate ROS. ► Knockdown of TrxR1 augments curcumin's cytotoxicity in HeLa cells.

  18. Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells

    International Nuclear Information System (INIS)

    Cai, Wenqing; Zhang, Baoxin; Duan, Dongzhu; Wu, Jincai; Fang, Jianguo

    2012-01-01

    The thioredoxin system, composed of thioredoxin reductase (TrxR), thioredoxin (Trx), and NADPH, is ubiquitous in all cells and involved in many redox-dependent signaling pathways. Curcumin, a naturally occurring pigment that gives a specific yellow color in curry food, is consumed in normal diet up to 100 mg per day. This molecule has also been used in traditional medicine for the treatment of a variety of diseases. Curcumin has numerous biological functions, and many of these functions are related to induction of oxidative stress. However, how curcumin elicits oxidative stress in cells is unclear. Our previous work has demonstrated the way by which curcumin interacts with recombinant TrxR1 and alters the antioxidant enzyme into a reactive oxygen species (ROS) generator in vitro. Herein we reported that curcumin can target the cytosolic/nuclear thioredoxin system to eventually elevate oxidative stress in HeLa cells. Curcumin-modified TrxR1 dose-dependently and quantitatively transfers electrons from NADPH to oxygen with the production of ROS. Also, curcumin can drastically down-regulate Trx1 protein level as well as its enzyme activity in HeLa cells, which in turn remarkably decreases intracellular free thiols, shifting the intracellular redox balance to a more oxidative state, and subsequently induces DNA oxidative damage. Furthermore, curcumin-pretreated HeLa cells are more sensitive to oxidative stress. Knockdown of TrxR1 sensitizes HeLa cells to curcumin cytotoxicity, highlighting the physiological significance of targeting TrxR1 by curcumin. Taken together, our data disclose a previously unrecognized prooxidant mechanism of curcumin in cells, and provide a deep insight in understanding how curcumin works in vivo. -- Highlights: ► Curcumin induces oxidative stress by targeting the thioredoxin system. ► Curcumin-modified TrxR quantitatively oxidizes NADPH to generate ROS. ► Knockdown of TrxR1 augments curcumin's cytotoxicity in HeLa cells. ► Curcumin

  19. Local and systemic oxidative stress and glucocorticoid receptor levels in chronic obstructive pulmonary disease patients

    Science.gov (United States)

    Zeng, Mian; Li, Yue; Jiang, Yujie; Lu, Guifang; Huang, Xiaomei; Guan, Kaipan

    2013-01-01

    BACKGROUND: Previous studies have indicated that oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). OBJECTIVES: To study local and systemic oxidative stress status in COPD patients, and to clarify the relationship between local and systemic oxidative stress. METHODS: Lipid peroxide malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD) and GSH peroxidase (GSH-PX) levels in induced sputum and plasma, as well as glucocorticoid receptor (GR) levels in peripheral blood leukocytes were examined in 43 acute exacerbation of COPD patients (group A), 35 patients with stable COPD (group B) and 28 healthy controls (14 smokers [group C]; 14 nonsmokers [group D]). RESULTS: MDA levels in induced sputum and plasma decreased progressively in groups A to D, with significant differences between any two groups (P<0.001). GSH, SOD and GSH-PX levels in both induced sputum and plasma increased progressively in groups A to D, with significant differences between any two groups (P<0.001). GR levels in peripheral blood leukocytes decreased progressively in groups D to A (all comparisons P<0.001). Pearson analysis revealed strong correlations between MDA, GSH, SOD and GSH-PX levels in plasma and induced sputum. The activity of SOD in plasma and sputum were both positively correlated with GR levels (partial correlation coefficients 0.522 and 0.574, respectively [P<0.001]). CONCLUSIONS: Oxidative stress levels were elevated in COPD patients. There was a correlation between local and systemic oxidative status in COPD, and between decreased SOD activity and decreased GR levels in COPD patients. PMID:23457673

  20. Multi-axis force sensing using a resonant composite piezoelectric plate: model and experiments

    Science.gov (United States)

    Castaño-Cano, Davinson; Grossard, Mathieu; Hubert, Arnaud

    2015-05-01

    Wrist force/torque sensors used in robotic applications increase the performances and flexibility of the automated tasks. They also offer new possibilities in the manufacturing process, where physical contact between the work-piece and environment is required. The wide spreading of these sensors is for now restricted by their features. As an alternative to the existing strain-gauges force sensors, this paper presents a resonant composite structure, which is sensitive to multiple components of force that are considered via the pre-stress effect. Structurally bonded piezoelectric patches are used to bring the structure to its resonance, which is shifted according to applied forces. The relationship between force and frequency shift is modelled considering the multi-physics of this smart structure. This model is built using Hamilton's principle and takes into account pre-stress phenomena. A finite element model (FEM) based on Mindlin theory for plates, has been derived from the analytical model. The FEM model is implemented in MATLAB and compared with commercial FE software. Finally, an experimental prototype validates the model, and shows that it is possible to measure multiple force-components with one single sensing element such as a plate.

  1. Multi-axis force sensing using a resonant composite piezoelectric plate: model and experiments

    International Nuclear Information System (INIS)

    Castaño-Cano, Davinson; Grossard, Mathieu; Hubert, Arnaud

    2015-01-01

    Wrist force/torque sensors used in robotic applications increase the performances and flexibility of the automated tasks. They also offer new possibilities in the manufacturing process, where physical contact between the work-piece and environment is required. The wide spreading of these sensors is for now restricted by their features. As an alternative to the existing strain-gauges force sensors, this paper presents a resonant composite structure, which is sensitive to multiple components of force that are considered via the pre-stress effect. Structurally bonded piezoelectric patches are used to bring the structure to its resonance, which is shifted according to applied forces. The relationship between force and frequency shift is modelled considering the multi-physics of this smart structure. This model is built using Hamilton's principle and takes into account pre-stress phenomena. A finite element model (FEM) based on Mindlin theory for plates, has been derived from the analytical model. The FEM model is implemented in MATLAB and compared with commercial FE software. Finally, an experimental prototype validates the model, and shows that it is possible to measure multiple force-components with one single sensing element such as a plate. (paper)

  2. Finite element simulation of stress evolution in thermal barrier coating systems

    Energy Technology Data Exchange (ETDEWEB)

    Bednarz, P.

    2007-07-01

    Gas turbine materials exposed to extreme high temperature require protective coatings. To design reliable components, a better understanding of the coating failure mechanisms is required. Damage in Thermal Barrier Coating Systems (TBCs) is related to oxidation of the Bond Coat, sintering of the ceramic, thermal mismatch of the material constituents, complex shape of the BC/TGO/TBC interface, redistribution of stresses via creep and plastic deformation and crack resistance. In this work, experimental data of thermo-mechanical properties of CMSX-4, MCrAlY (Bond Coat) and APS-TBC (partially stabilized zirconia), were implemented into an FE-model in order to simulate the stress development at the metal/ceramic interface. The FE model reproduced the specimen geometry used in corresponding experiments. It comprises a periodic unit cell representing a slice of the cylindrical specimen, whereas the periodic length of the unit cell equals an idealized wavelength of the rough metal/ceramic interface. Experimental loading conditions in form of thermal cycling with a dwelltime at high temperature and consideration of continuous oxidation were simulated. By a stepwise consideration of various material properties and processes, a reference model was achieved which most realistically simulated the materials behavior. The influences of systematic parameter variations on the stress development and critical sites with respect to possible crack paths were shown. Additionally, crack initiation and propagation at the peak of asperity at BC/TGO interface was calculated. It can be concluded that a realistic modeling of stress development in TBCs requires at least reliable data of i) BC and TGO plasticity, ii) BC and TBC creep, iii) continuous oxidation including in particular lateral oxidation, and iv) critical energy release rate for interfaces (BC/TGO, TGO/TBC) and for each layer. The main results from the performed parametric studies of material property variations suggest that

  3. Why social attachment and oxytocin protect against addiction and stress: Insights from the dynamics between ventral and dorsal corticostriatal systems.

    NARCIS (Netherlands)

    Tops, M.; Koole, S.L.; IJzerman, H.; Buisman-Pijlman, F.T.

    2014-01-01

    The present article advances a neurobiological model of the reciprocal associations between social attachment and drug abuse, and social attachment and chronic stress, as overlapping systems are involved in stress coping and social attachment. In terms of coping, responding to a novel stressor or

  4. Why social attachment and oxytocin protect against addiction and stress : Insights from the dynamics between ventral and dorsal corticostriatal systems

    NARCIS (Netherlands)

    Tops, M.; Koole, S.L.; Ijzerman, H.; Buisman-Pijlman, F.T.A.

    2014-01-01

    The present article advances a neurobiological model of the reciprocal associations between social attachment and drug abuse, and social attachment and chronic stress, as overlapping systems are involved in stress coping and social attachment. In terms of coping, responding to a novel stressor or

  5. Stress and Female Reproductive System: Disruption of Corticotropin-Releasing Hormone/Opiate Balance by Sympathetic Nerve Traffic

    Directory of Open Access Journals (Sweden)

    Farideh Zafari Zangeneh

    2009-09-01

    Full Text Available Nowadays stress is an integral part of everyday living and the physiological and behavioral consequences of exposure to stressful situations have been extensively studied for decades. The stress response is a necessary mechanism but disrupts homeostatic process and it is sub served by a complex system located in both the central nervous system (CNS and the periphery. Stressor-induced activation of the hypothalamus–pituitary–adrenal (HPA axis and the sympathetic nervous system (SNS results in a series of neural and endocrine adaptations known as the "stress response" or "stress cascade." The stress cascade is responsible for allowing the body to make the necessary physiological and metabolic changes required to cope with the demands of a homeostatic challenge. Normal activation of the HPA axis is essential for reproduction, growth, metabolic homeostasis, and responses to stress and they are critical for adapting to changes in the external environment. The regulation of gonadal function in men and women is under the control of the HPA. This regulation is complex and sex steroids are important regulators of GnRH and gonadotropin release through classical feedback mechanisms in the hypothalamus and the pituitary. The present overview focuses on the neuroendocrine infrastructure of the adaptive response to stress and its effects on the female reproductive system

  6. Use of Saliva for Assessment of Stress and Its Effect on the Immune System Prior to Gross Anatomy Practical Examinations

    Science.gov (United States)

    Lester, S. Reid; Brown, Jason R.; Aycock, Jeffrey E.; Grubbs, S. Lee; Johnson, Roger B.

    2010-01-01

    The objective of this study was to determine the longitudinal effects of a series of stressful gross anatomy tests on the immune system. Thirty-six freshman occupational therapy students completed a written stress evaluation survey, and saliva samples were obtained at baseline and prior to each of three timed-practical gross anatomy tests.…

  7. Elevated Psychosocial Stress at Work in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis.

    Science.gov (United States)

    Richter, Jutta G; Muth, Thomas; Li, Jian; Brinks, Ralph; Chehab, Gamal; Koch, Tobias; Siegrist, Johannes; Angerer, Peter; Huscher, Dörte; Schneider, Matthias

    2018-02-01

    Psychosocial stress at work not only affects the healthy working population, but also workers with chronic diseases. We aimed to investigate the psychosocial work stress levels in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). A cross-sectional study applied the Effort-Reward Imbalance (ERI) questionnaire - an internationally established instrument that measures work stress - to patients with SLE and RA who were capable of work and to a group of controls without these diseases. Participants were recruited through rheumatologists in private practices, hospitals, and from self-help groups by personal communication, paper-based flyers, and online advertisements. Because very few studies tested the ERI's applicability in patient groups, with a lack of evidence in patients with inflammatory rheumatic diseases, internal consistency and construct validity of the ERI measure were evaluated. Data came from 270 patients with RA and 247 with SLE, and 178 controls. Patients showed elevated psychosocial stress at work compared to controls. Across the total sample and all groups, satisfactory internal consistencies of the scales effort, reward, and overcommitment were obtained (Cronbach's alpha coefficients > 0.70), and confirmatory factor analysis replicated the theoretical structure of the ERI model (goodness-of-fit index > 0.80). We found elevated psychosocial stress at work in patients with SLE and RA compared to controls by applying the ERI model. Despite some heterogeneity in the sample, we achieved satisfactory psychometric properties of the ERI questionnaire. Our results suggest that the ERI questionnaire is a psychometrically useful tool to be implemented in epidemiological studies of employed patients with SLE and RA.

  8. Impact of water-deficit stress on tritrophic interactions in a wheat-aphid-parasitoid system.

    Directory of Open Access Journals (Sweden)

    Syed Suhail Ahmed

    Full Text Available Increasing temperature and CO2 concentrations can alter tritrophic interactions in ecosystems, but the impact of increasingly severe drought on such interactions is not well understood. We examined the response of a wheat-aphid-parasitoid system to variation in water-deficit stress levels. Our results showed that arid area clones of the aphid, Sitobion avenae (Fabricius, tended to have longer developmental times compared to semiarid and moist area clones, and the development of S. avenae clones tended to be slower with increasing levels of water-deficit. Body sizes of S. avenae clones from all areas decreased with increasing water-deficit levels, indicating their declining adaptation potential under drought. Compared to arid area clones, moist area clones of S. avenae had a higher frequency of backing under severe water stress only, but a higher frequency of kicking under well-watered conditions only, suggesting a water-deficit level dependent pattern of resistance against the parasitoid, Aphidius gifuensis (Ashmead. The number of S. avenae individuals attacked by the parasitoid in 10 min showed a tendency to decrease with increasing water-deficit levels. Clones of S. avenae tended to have lower parasitism rates under treatments with higher water-deficit levels. The development of the parasitoid tended to be slower under higher levels of water-deficit stress. Thus, the bottom-up effects of water-deficit stressed plants were negative on S. avenae. However, the top-down effects via parasitoids were compromised by water-deficit, which could favor the growth of aphid populations. Overall, the first trophic level under water-deficit stress was shown to have an indirect and negative impact on the third trophic level parasitoid, suggesting that parasitoids could be increasingly vulnerable in future warming scenarios.

  9. Regulation of the corticosteroid signalling system in rainbow trout HPI axis during confinement stress.

    Science.gov (United States)

    Kiilerich, Pia; Servili, Arianna; Péron, Sandrine; Valotaire, Claudiane; Goardon, Lionel; Leguen, Isabelle; Prunet, Patrick

    2018-03-01

    This study aims to shed light on corticosteroid regulation of stress in teleost fish with focus on the corticosteroid signalling system. The role of the mineralocorticoid-like hormone 11-deoxycorticosterone (DOC) in fish is still enigmatic, as is the function of the mineralocorticoid receptor, MR. Low plasma DOC levels and ubiquitous tissue distribution of MR question the physiological relevance of the mineralocorticoid-axis. Furthermore, the particular purpose of each of the three corticosteroid receptors in fish, the glucocorticoid receptors, GR1 and GR2, and the MR, is still largely unknown. Therefore we investigate the regulation of cortisol and DOC in plasma and mRNA levels of MR, GR1 and GR2 in the HPI-axis tissues (hypothalamus, pituitary and interrenal gland) during a detailed confinement stress time-course. Here we show a sustained up-regulation of plasma DOC levels during a confinement stress time-course. However, the low DOC levels compared to cortisol measured in the plasma do not favour an activity of DOC through MR receptors. Furthermore, we show differential contribution of the CRs in regulation and control of HPI axis activity following confinement stress. Judged by the variation of mRNA levels negative feedback regulation of cortisol release occurs on the level of the pituitary via MR and on the level of the interrenal gland via GR2. Finally, asa significant effect of confinement stress on CR expressions was observed in the pituitary gland, we completed this experiment by demonstrating that corticosteroid receptors (GR1, GR2 and MR) are co-expressed in the ACTH cells located in the adenohypophysis. Overall, these data suggest the involvement of these receptors in the regulation of the HPI axis activity by cortisol. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Perceived stress and reported cognitive symptoms among Georgia patients with systemic lupus erythematosus.

    Science.gov (United States)

    Plantinga, L; Lim, S S; Bowling, C B; Drenkard, C

    2017-09-01

    Objective To examine associations of perceived stress with cognitive symptoms among adults with systemic lupus erythematosus (SLE). Methods Among 777 adult (≥18 years) SLE patients, the association of Perceived Stress Scale (PSS) scores with two self-reported cognitive symptoms was examined: forgetfulness (severe/moderate vs. mild/none; from the Systemic Lupus Activity Questionnaire) and difficulty concentrating (all/most vs. some/little/none of the time; from the Lupus Impact Tracker). The study used multivariable logistic regression to estimate the odds ratios (ORs) per minimal important difference (MID = 0.5*SD) of PSS score and cognitive symptoms. Results Forgetfulness and difficulty concentrating were reported by 41.7% and 29.5%, respectively. Women and those with less education and high disease activity had higher PSS scores and were more likely to report cognitive symptoms than their counterparts. With adjustment for age, race, sex, education, and disease activity, each MID increase in PSS score was associated with higher prevalence of forgetfulness (OR = 1.43, 95% CI 1.29-1.47) and difficulty concentrating (OR = 2.19, 95% CI 1.90-2.52). No substantial differences in this association by age, race, sex, or disease activity were noted. Conclusions SLE patients, particularly those with high disease activity, report a high burden of cognitive symptoms, for which stress may be a modifiable risk factor.

  11. Retinol, β-carotene and oxidative stress in systemic inflammatory response syndrome

    Directory of Open Access Journals (Sweden)

    Carla Nogueira

    2015-04-01

    Full Text Available Objective: patients suffering systemic inflammatory response syndrome (SIRS constitute a group susceptible to elevated levels of oxidative stress. This study’s aim is to evaluate the state of oxidative stress and levels of serum retinol and β-carotene in these patients. Methods: forty-six patients were divided into 2 groups: those those without diet (G1; n=18 and those with enteral nutritional support (G2; n=28. Serum levels of retinol and total carotenoids were measured. C-reactive protein (CRP levels and Apache scores were also calculated. Oxidative stress was estimated by measuring thiobarbituric acid reactive substance (TBARS levels. Results: the patients’ median age was 66.9 (SD=19.3 years. Lower concentrations of retinol and carotenoids were found in 68.6 and 66.7% of G1, respectively. In G2, despite average vitamin A levels being 8078 + 4035, retinol and β-carotene were considered insufficient (31.2 and 33.4%, respectively. No difference was noted between the 2 groups, according to the variables studied, with the exception being PCR and β-carotene (p=0.002; p=0.01. Conclusion: the data presented in this study supports the need to establish/revise clinical practices in treating SIRS patients, in light of this micronutrient’s role in the immune system and antioxidant defense without it interfering with its toxicity.

  12. Fetal alcohol programming of hypothalamic proopiomelanocortin system by epigenetic mechanisms and later life vulnerability to stress.

    Science.gov (United States)

    Bekdash, Rola; Zhang, Changqing; Sarkar, Dipak

    2014-09-01

    Hypothalamic proopiomelanocortin (POMC) neurons, one of the major regulators of the hypothalamic-pituitary-adrenal (HPA) axis, immune functions, and energy homeostasis, are vulnerable to the adverse effects of fetal alcohol exposure (FAE). These effects are manifested in POMC neurons by a decrease in Pomc gene expression, a decrement in the levels of its derived peptide β-endorphin and a dysregulation of the stress response in the adult offspring. The HPA axis is a major neuroendocrine system with pivotal physiological functions and mode of regulation. This system has been shown to be perturbed by prenatal alcohol exposure. It has been demonstrated that the perturbation of the HPA axis by FAE is long-lasting and is linked to molecular, neurophysiological, and behavioral changes in exposed individuals. Recently, we showed that the dysregulation of the POMC system function by FAE is induced by epigenetic mechanisms such as hypermethylation of Pomc gene promoter and an alteration in histone marks in POMC neurons. This developmental programming of the POMC system by FAE altered the transcriptome in POMC neurons and induced a hyperresponse to stress in adulthood. These long-lasting epigenetic changes influenced subsequent generations via the male germline. We also demonstrated that the epigenetic programming of the POMC system by FAE was reversed in adulthood with the application of the inhibitors of DNA methylation or histone modifications. Thus, prenatal environmental influences, such as alcohol exposure, could epigenetically modulate POMC neuronal circuits and function to shape adult behavioral patterns. Identifying specific epigenetic factors in hypothalamic POMC neurons that are modulated by fetal alcohol and target Pomc gene could be potentially useful for the development of new therapeutic approaches to treat stress-related diseases in patients with fetal alcohol spectrum disorders. Copyright © 2014 by the Research Society on Alcoholism.

  13. Stressing fish in Recirculating Aquaculture Systems (RAS): Does stress induced in one group of fish affect the feeding motivation of other fish sharing the same RAS?

    NARCIS (Netherlands)

    Martins, C.I.; Eding, E.H.; Verreth, J.A.J.

    2011-01-01

    As a consequence of water re-use and high stocking densities, Recirculating Aquaculture Systems (RAS) may lead to an accumulation of substances released by the fish into the water, e.g. cortisol and alarm pheromones. This study investigated the effect of stressing fish on the feeding motivation of

  14. Targeting the oxidative stress response system of fungi with safe, redox-potent chemosensitizing agents

    Directory of Open Access Journals (Sweden)

    Jong H. eKim

    2012-03-01

    Full Text Available The cellular antioxidation system is a target in the antifungal action of amphotericin B (AMB and itraconazole (ITZ, in filamentous fungi. The sakAΔ mutant of Aspergillus fumigatus, a mitogen-activated protein kinase (MAPK gene deletion mutant in the antioxidation system, was found to be more sensitive to AMB or ITZ than other A. fumigatus strains, a wild type and a mpkCΔ mutant (MAPK gene deletion mutant in polyalcohol sugar utilization system. The sakAΔ mutant showed no growth at 0.5 μg mL-1 of ITZ or reduced growth at 1.0 to 2.0 μg mL-1 of AMB, while the other strains exhibited robust growth. Complete fungal kill (≥ 99.9% by ITZ or AMB was achieved by much lower dosages for the sakAΔ mutant than for the other strains. SakA and MpkC appear to have overlapping roles in marshalling the oxidative stress response under treatment by an organic peroxide, tert-butyl hydroperoxide (t-BuOOH, or hydrogen peroxide (H2O2. The SakA signalling pathway was found to be responsible for fungal tolerance to AMB or ITZ toxicity. It appears msnA, an Aspergillus ortholog to Saccharomyces cerevisiae MSN2 (encoding a stress-responsive C2H2-type zinc-finger regulator and sakA and/or mpkC (upstream MAPKs are in the same stress response network under t-BuOOH-, H2O2- or AMB-triggered toxicity. Of note is that ITZ-sensitive yeast pathogens (Candida krusei and Cryptococcus neoformans were also sensitive to t-BuOOH, showing a connection between ITZ toxicity and oxidative stress response. This was shown by enhanced antifungal activity of AMB or ITZ when co-applied with redox-potent natural compounds, 2,3-dihydroxybenzaldehyde, thymol or salicylaldehyde, as chemosensitizing agents. Hence, redox compounds, which target the antioxidation system in fungi, possess a potent chemosensitizing capacity to enhance efficacy of conventional drugs inducing oxidative stress. Such chemosensitization can reduce costs and alleviate negative side effects associated with current

  15. How arbuscular mycorrhizal fungi influence the defense system of sunflower during different abiotic stresses.

    Science.gov (United States)

    Mayer, Zoltán; Duc, Nguyen Hong; Sasvári, Zita; Posta, Katalin

    2017-12-01

    The association between terrestrial plants and arbuscular mycorrhizal (AM) fungi is one of the most common and widespread mutualistic plant-fungi interaction. AM fungi are of beneficial effects on the water and nutrient uptake of plants and increase plant defense mechanisms to alleviate different stresses. The aim of this study was to determine the level of polyphenol oxidase (PPO), guaiacol peroxidase (POX) and glutathione S-transferase (GST) enzyme activities and to track the expression of glutathione S-transferase (GST) gene in plant-arbuscular mycorrhizal system under temperature- and mechanical stress conditions. Our results suggest that induced tolerance of mycorrhizal sunflower to high temperature may be attributed to the induction of GST, POX and PPO enzyme activities as well as to the elevated expression of GST. However, the degree of tolerance of the plant is significantly influenced by the age which is probably justified by the energy considerations.

  16. Long-Term Effects of Neonatal Pain and Stress on Reactivity of the Nociceptive System.

    Science.gov (United States)

    Butkevich, I P; Mikhailenko, V A

    2016-10-01

    The influence of inflammatory pain and/or weaning stress at different terms of neonatal development on functional activity of the nociceptive system during adulthood was studied in rats. Repeated stress in 1-2-day-old rat pups (a premature baby model) enhanced pain sensitivity to peripheral inflammation in both males and females. Repeated inflammatory pain experienced by male pups aged 1-2 or 7-8 days (models of preterm and full-term baby), even in presence of mother, enhanced pain behavior under conditions of repeated inflammatory pain in adulthood. Pain sensitivity in adult animals before (hot plate test) and after formation of the inflammatory focus (formalin test) depended on the age when the animals were subjected to the injury, type of exposure, and on animal sex. The priority data obtained by us will help to understand the mechanisms of long-term effects of early injuries and are important for pediatricians and neonatologists.

  17. Effects of the antipsychotic paliperidone on stress-induced changes in the endocannabinoid system in rat prefrontal cortex.

    Science.gov (United States)

    MacDowell, Karina S; Sayd, Aline; García-Bueno, Borja; Caso, Javier R; Madrigal, José L M; Leza, Juan Carlos

    2017-09-01

    Objectives There is a need to explore novel mechanisms of action of existing/new antipsychotics. One potential candidate is the endocannabinoid system (ECS). The present study tried to elucidate the effects of the antipsychotic paliperidone on stress-induced ECS alterations. Methods Wister rats were submitted to acute/chronic restraint stress. Paliperidone (1 mg/kg) was given prior each stress session. Cannabinoid receptors and endocannabinoids (eCBs) synthesis and degradation enzymes were measured in prefrontal cortex (PFC) samples by RT-PCR and Western Blot. Results In the PFC of rats exposed to acute stress, paliperidone increased CB1 receptor (CB1R) expression. Furthermore, paliperidone increased the expression of the eCB synthesis enzymes N-acylphosphatidylethanolamine- hydrolysing phospholipase D and DAGLα, and blocked the stress-induced increased expression of the degrading enzyme fatty acid amide hydrolase. In chronic conditions, paliperidone prevented the chronic stress-induced down-regulation of CB1R, normalised DAGLα expression and reverted stress-induced down-regulation of the 2-AG degrading enzyme monoacylglycerol lipase. ECS was analysed also in periphery. Acute stress decreased DAGLα expression, an effect prevented by paliperidone. Contrarily, chronic stress increased DAGLα and this effect was potentiated by paliperidone. Conclusions The results obtained described a preventive effect of paliperidone on stress-induced alterations in ECS. Considering the diverse alterations on ECS described in psychotic disease, targeting ECS emerges as a new therapeutic possibility.

  18. A multi-axis confocal rheoscope for studying shear flow of structured fluids

    KAUST Repository

    Lin, Neil Y. C.

    2014-03-01

    We present a new design for a confocal rheoscope that enables uniform uniaxial or biaxial shear. The design consists of two precisely positioned parallel plates with a gap that can be adjusted down to 2 ±0.1 μm, allowing for the exploration of confinement effects. By using our shear cell in conjunction with a biaxial force measurement device and a high-speed confocal microscope, we are able to measure the real-time biaxial stress while simultaneously imaging the material three-dimensional structure. We illustrate the importance of the instrument capabilities by discussing the applications of this instrument in current and future research topics in colloidal suspensions. © 2014 AIP Publishing LLC.

  19. Anti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats.

    Science.gov (United States)

    Park, Hyun-Jung; Shim, Hyun Soo; Lee, Sunyoung; Hahm, Dae Hyun; Lee, Hyejung; Oh, Chang Taek; Han, Hae Jung; Ji, Hyi Jeong; Shim, Insop

    2018-05-08

    Human placenta hydrolysate (hPH) has been utilized to improve menopausal, fatigue, liver function. Its high concentration of bioactive substances is known to produce including antioxidant, anti-inflammatory and anti-nociceptive activities. However, its mechanisms of stress-induced depression remain unknown. The present study examined the effect of hPH on stress-induced depressive behaviors and biochemical parameters in rats. hPH (0.02 ml, 0.2 ml or 1 ml/rat) was injected intravenously 30 min before the daily stress session in male Sprague-Dawley rats exposed to repeated immobilization stress (4 h/day for 7 days). The depressive-like behaviors of all groups were measured by elevated plus maze (EPM) and forced swimming test (FST). After the behavior tests, brain samples of all groups were collected for the analysis of glutathione peroxidase (GPx) and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) staining. Treatment with hPH produced a significant decrease of immobility time in the FST compared to the controls. Additionally, hPH treatment elicited a slightly decreasing trend in anxiety behavior on the EPM. Furthermore, hPH increased the level of GPx protein in the hippocampus, and decreased the expression of NADPH-d in the paraventricular nucleus (PVN). This study demonstrated that hPH has anti-stress effects via the regulation of nitric oxide (NO) synthase and antioxidant activity in the brain. These results suggest that hPH may be useful in the treatment of stress-related diseases such as chronic fatigue syndrome.

  20. Stress-strain state analysis and optimization of rod system under periodic pulse load

    Directory of Open Access Journals (Sweden)

    Grebenyuk Grigory

    2018-01-01

    Full Text Available The paper considers the problem of analysis and optimization of rod systems subjected to combined static and periodic pulse load. As a result of the study the analysis method was developed based on traditional approach to solving homogeneous matrix equations of state and a special algorithm for developing a particular solution. The influence of pulse parameters variations on stress-strain state of a rod system was analyzed. Algorithms for rod systems optimization were developed basing on strength recalculation and statement and solution of optimization problem as a problem of nonlinear mathematical programming. Recommendations are developed for efficient organization of process for optimization of rod systems under static and periodic pulse load.

  1. An automated data management/analysis system for space shuttle orbiter tiles. [stress analysis

    Science.gov (United States)

    Giles, G. L.; Ballas, M.

    1982-01-01

    An engineering data management system was combined with a nonlinear stress analysis program to provide a capability for analyzing a large number of tiles on the space shuttle orbiter. Tile geometry data and all data necessary of define the tile loads environment accessed automatically as needed for the analysis of a particular tile or a set of tiles. User documentation provided includes: (1) description of computer programs and data files contained in the system; (2) definitions of all engineering data stored in the data base; (3) characteristics of the tile anaytical model; (4) instructions for preparation of user input; and (5) a sample problem to illustrate use of the system. Description of data, computer programs, and analytical models of the tile are sufficiently detailed to guide extension of the system to include additional zones of tiles and/or additional types of analyses

  2. Development of a global Agricultural Stress Index System (ASIS) based on remote sensing data

    Science.gov (United States)

    Van Hoolst, R.

    2016-12-01

    According to the 2012 IPCC SREX report, extreme drought events are projected to become more frequent and intense in several regions of the world. Wide and timely monitoring systems are required to mitigate the impact of agricultural drought. Therefore, FAO's Global Information and Early Warning System (GIEWS) and the Climate, Energy and Tenure Division (NRC) have established the `Agricultural Stress Index System' (ASIS). The ASIS is a remote sensing application that provides early warnings of agricultural drought at a global scale. The ASIS has first been designed and described by Rojas et al. (2011). This study focused on the African continent and was based on the back processing of low resolution data of the NOAA-satellites. In the current setup, developed by VITO (Flemish Institute for Technological Research), the system operates in Near Real Time using data from the METOP-AVHRR sensor. The Agricultural Stress Index (ASI) is the percentage of agricultural area affected by drought in the course of the growing season within a given administrative unit. The start and end of the growing season are derived per pixel from the long term NDVI average of SPOT-VEGETATION. The Global Administrative Unit Layer (GAUL) defines the administrative boundaries at level 0, 1 and 2. A global cropland and grassland map eliminates non-agricultural areas. Temperature and NDVI anomalies are used as drought indicators and calculated at a per pixel base. The ASIS aggregates this information and produces every dekad global maps to highlight hotspots of drought stress. New developments are ongoing to strengthen the ASIS to produce country specific outputs, improve existing drought indicators and estimate production deficits using a probabilistic approach.

  3. Airborne multi-axis DOAS measurements of tropospheric SO2 plumes in the Po-valley, Italy

    Directory of Open Access Journals (Sweden)

    P. Wang

    2006-01-01

    Full Text Available During the second FORMAT (FORMaldehyde as A Tracer of oxidation in the troposphere campaign in 2003 the airborne multi-axis DOAS instrument (AMAXDOAS performed scattered-light spectroscopic measurements of SO2 over the city of Mantova and the power plant Porto Tolle, both situated in the Po-valley, Northern Italy. The SO2 vertical columns and emission flux were derived from two days of measurements, 26 and 27 September 2003. The SO2 emission flux from the power plant Porto Tolle was calculated to 1.93×1025 molec s-1 on 26 September and in good agreement with official emission data, which quote 2.25×1025 molec s-1. On 27 September the measured flux was much lower (3.77×1024 molec s-1 if ECMWF wind data are used, but of comparable magnitude (2.4×1025 molec s-1 if the aircraft on-board wind measurements are utilised. Official emission data was 2.07×1025 molec s-1 indicating only a small change from the previous day. Over the city of Mantova, the observed SO2 vertical columns were 1.1×1016 molec cm-2 and 1.9×1016 molec cm-2 on 26 and 27 September, respectively. This is in good agreement with ground-based measurements of 5.9 ppbv and 10.0 ppbv which correspond to 1.2×1016 molec cm-2 and 2.2×1016 molec cm-2 if a well mixed boundary layer of 500m altitude is assumed.

  4. Piping Stress analysis for primary system of nuclear power plant AP-600

    International Nuclear Information System (INIS)

    Tjahjono, Hendro; Arhatari, B.D.; W, Pustandyo; Sitandung, J.B; Sudarmaji, Djoko

    1999-01-01

    Piping stress analysis for AP-600 primary system has been done using software CAEPIPE and PS-CAEPIPE. The loading applied to the system are static and seismic category I and II piping in reactor building have been analysed, those are PXS-900, CVS-110, PCS-030, CAS-700 and CCS-050. These system contain pipes with the normal diameter of 1 , 2 , 4 a nd 8 . The design pressures are in the range of 150oF to 300oF. The acceleration taken as input in PS-CAEPIPE is based on seismic response spectra of floor the piping is located. In CAEPIPE, the acceleration taken from the peak of response spectra multiplied by 1.7 all of the acceleration in this case are no more than 0.36g. The result shows that after locating some supports, all system are acceptable without snubbers. The maximum stress are 11210 psi for deadweight load and 35593 psi for total load (the allowable values are 15000 psi and 45000 psi). The maximum displacement are 0.123 in for deadweight load, 1.474 in for hot load seismic load (the allowable values are 0.125 in for deadweight and 2.5 in for total load). The difference results of the both software is mainly in seismic calculation where mare parameters can be evaluated by PS-CAEPIPE including to evaluate valves acceleration in seismic condition

  5. Monitoring microstructural evolution of alloy 617 with non-linear acoustics for remaining useful life prediction; multiaxial creep-fatigue and creep-ratcheting

    Energy Technology Data Exchange (ETDEWEB)

    Lissenden, Cliff [Pennsylvania State Univ., State College, PA (United States); Hassan, Tasnin [North Carolina State Univ., Raleigh, NC (United States); Rangari, Vijaya [Tuskegee Univ., Tuskegee, AL (United States)

    2014-10-30

    The research built upon a prior investigation to develop a unified constitutive model for design-­by-­analysis of the intermediate heat exchanger (IHX) for a very high temperature reactor (VHTR) design of next generation nuclear plants (NGNPs). Model development requires a set of failure data from complex mechanical experiments to characterize the material behavior. Therefore uniaxial and multiaxial creep-­fatigue and creep-­ratcheting tests were conducted on the nickel-­base Alloy 617 at 850 and 950°C. The time dependence of material behavior, and the interaction of time dependent behavior (e.g., creep) with ratcheting, which is an increase in the cyclic mean strain under load-­controlled cycling, are major concerns for NGNP design. This research project aimed at characterizing the microstructure evolution mechanisms activated in Alloy 617 by mechanical loading and dwell times at elevated temperature. The acoustic harmonic generation method was researched for microstructural characterization. It is a nonlinear acoustics method with excellent potential for nondestructive evaluation, and even online continuous monitoring once high temperature sensors become available. It is unique because it has the ability to quantitatively characterize microstructural features well before macroscale defects (e.g., cracks) form. The nonlinear acoustics beta parameter was shown to correlate with microstructural evolution using a systematic approach to handle the complexity of multiaxial creep-­fatigue and creep-­ratcheting deformation. Mechanical testing was conducted to provide a full spectrum of data for: thermal aging, tensile creep, uniaxial fatigue, uniaxial creep-­fatigue, uniaxial creep-ratcheting, multiaxial creep-fatigue, and multiaxial creep-­ratcheting. Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), and Optical Microscopy were conducted to correlate the beta parameter with individual microstructure mechanisms. We researched

  6. Multi-axial model of anisotropic damage: numerical management of failure and application to the ruin of reinforced concrete structures under impact

    International Nuclear Information System (INIS)

    Leroux, A.

    2012-01-01

    The objective of this research thesis is to develop the most precise possible numeric modelling of reinforced concrete behaviour with application to the design of structures of protection of nuclear plants against violent dynamic loadings (explosions, impacts). After a discussion of existing models, of their benefits and weaknesses, a multi-axial model of anisotropic damage is proposed and implemented with the finite element method. A new procedure of failure management is also proposed which allows the induced anisotropic damage to be taken into account. Impact tests on concrete beams and concrete cubes with longitudinal steel have been performed in order to validate the model [fr

  7. Monitoring microstructural evolution of alloy 617 with non-linear acoustics for remaining useful life prediction; multiaxial creep-fatigue and creep-ratcheting

    International Nuclear Information System (INIS)

    Lissenden, Cliff; Hassan, Tasnin; Rangari, Vijaya

    2014-01-01

    The research built upon a prior investigation to develop a unified constitutive model for design-@by-@analysis of the intermediate heat exchanger (IHX) for a very high temperature reactor (VHTR) design of next generation nuclear plants (NGNPs). Model development requires a set of failure data from complex mechanical experiments to characterize the material behavior. Therefore uniaxial and multiaxial creep-@fatigue and creep-@ratcheting tests were conducted on the nickel base Alloy 617 at 850 and 950°C. The time dependence of material behavior, and the interaction of time dependent behavior (e.g., creep) with ratcheting, which is an increase in the cyclic mean strain under load-@controlled cycling, are major concerns for NGNP design. This research project aimed at characterizing the microstructure evolution mechanisms activated in Alloy 617 by mechanical loading and dwell times at elevated temperature. The acoustic harmonic generation method was researched for microstructural characterization. It is a nonlinear acoustics method with excellent potential for nondestructive evaluation, and even online continuous monitoring once high temperature sensors become available. It is unique because it has the ability to quantitatively characterize microstructural features well before macroscale defects (e.g., cracks) form. The nonlinear acoustics beta parameter was shown to correlate with microstructural evolution using a systematic approach to handle the complexity of multiaxial creep-@fatigue and creep-@ratcheting deformation. Mechanical testing was conducted to provide a full spectrum of data for: thermal aging, tensile creep, uniaxial fatigue, uniaxial creep-@fatigue, uniaxial creep-ratcheting, multiaxial creep-fatigue, and multiaxial creep-@ratcheting. Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), and Optical Microscopy were conducted to correlate the beta parameter with individual microstructure mechanisms. We researched application of the

  8. Finite element analysis of stress concentration in three popular brands of fiber posts systems used for maxillary central incisor teeth.

    Science.gov (United States)

    Aggarwal, Shalini; Garg, Vaibhav

    2011-07-01

    To study the stress concentrations in endodontically treated maxillary central incisor teeth restored with 3 different fiber post systems subjected to various oblique occlusal loads. FEM analysis was used to analyze stress concentrations generated in maxillary anterior teeth. Computer aided designing was used to create a 2-D model of an upper central incisor. Post systems analyzed were the DT Light Post (RDT, Bisco), Luscent Anchor (Dentatus) & RelyX (3M-ESPE). The entire design assembly was subjected to analysis by ANSYS for oblique loading forces of 25N, 80N & 125 N RESULTS: The resultant data showed that the RelyX generated the least amount of stress concentration. Minimal stress buildups contribute to the longevity of the restorations. Thus RelyX by virtue of judicious stress distribution is the better option for restoration of grossly decayed teeth.

  9. A direct solution procedure for calculating time-varying stresses in structural systems by the principles of variational calculus

    International Nuclear Information System (INIS)

    Stefanou, G.D.

    1975-01-01

    The calculation of time-dependent stresses in structural systems operating at elevated temperatures with temperature gradients is discussed. The proposed method described in this report is of a direct formulation technique and

  10. Surgical treatment of female stress urinary incontinence with the Gynecare TVT Secur™ System – preliminary report

    Directory of Open Access Journals (Sweden)

    Włodzimierz Baranowski

    2010-02-01

    Full Text Available Introduction: Sling procedures were first introduced over 100 years ago in the treatment of stress urinaryincontinence. Since then they have evolved to become less invasive and safer. The sling procedure using theGynecare TVT Secur™ system is a new therapeutic option for women with stress urinary incontinence.Objectives: To evaluate the efficacy and safety of Gynecare TVT Secur™ in the surgical treatment of stressurinary incontinence in women. Material and methods: The study comprised consecutive female patients admitted to the Department ofGynaecology and Gynaecological Oncology of the Military Institute of Health Services in Warsaw, Poland, whohad been qualified for surgical treatment of stress urinary incontinence on the basis of physical signs and symptomsand the findings of a urodynamic study. The procedure was performed using the Gynecare TVT Secur™system with tapes introduced in an H- or U-shape mode. Results: Between October 2006 and September 2009, 77 sling procedures using the Gynecare TVT Secur™system were performed in women with stress urinary incontinence. Their mean age was 55.1 (30-76 years, meanBMI 28.5 (20.2-43.8 kg/m2. Sixty-nine implants were positioned in H-shape mode, 8 in U-shape mode. Fortyninewomen (63.6% were menopausal, 14 (18.2% previously had three or more natural deliveries, 13 (16.8%had a history of gynaecological surgeries. Thirty-one procedures were performed under general anaesthesia and46 under local anaesthesia. The mean duration of the surgery was 9 (4-42 minutes. It was possible to dischargefifty-seven (74% women on the day of the surgery. Urine retention was observed only in 1 (1.7% woman. Noother complications were recorded. Conclusions: The surgical treatment of urinary incontinence with sling procedures using the Gynecare TVTSecur™ system shows good immediate efficacy and safety. Considering this as well as the short duration ofthe procedure and its good tolerability under local anaesthesia, use

  11. Historical volcanism and the state of stress in the East African Rift System

    Directory of Open Access Journals (Sweden)

    Geoffrey Wadge

    2016-09-01

    Full Text Available Crustal extension at the East African Rift System (EARS should, as a tectonic ideal, involve a stress field in which the direction of minimum horizontal stress is perpendicular to the rift. A volcano in such a setting should produce dykes and fissures parallel to the rift. How closely do the volcanoes of the EARS follow this? We answer this question by studying the 21 volcanoes that have erupted historically (since about 1800 and find that 7 match the (approximate geometrical ideal. At the other 14 volcanoes the orientation of the eruptive fissures/dykes and/or the axes of the host rift segments are oblique to the ideal values. To explain the eruptions at these volcanoes we invoke local (non-plate tectonic variations of the stress field caused by: crustal heterogeneities and anisotropies (dominated by NW structures in the Protoerozoic basement, transfer zone tectonics at the ends of offset rift segments, gravitational loading by the volcanic edifice (typically those with 1-2 km relief and magmatic pressure in central reservoirs. We find that the more oblique volcanoes tend to have large edifices, large eruptive volumes and evolved and mixed magmas capable of explosive behaviour. Nine of the volcanoes have calderas of varying ellipticity, 6 of which are large, reservoir-collapse types mainly elongated across rift (e.g. Kone and 3 are smaller, elongated parallel to the rift and contain active lava lakes (e.g. Erta Ale, suggesting different mechanisms of formation and stress fields. Nyamuragira is the only EARS volcano with enough sufficiently well-documented eruptions to infer its long-term dynamic behaviour. Eruptions within 7 km of the volcano are of relatively short duration (<100 days, but eruptions with more distal fissures tend to have greater obliquity and longer durations, indicating a changing stress field away from the volcano. There were major changes in long-term magma extrusion rates in 1977 (and perhaps in 2002 due to major along

  12. Force and Stress along Simulated Dissociation Pathways of Cucurbituril-Guest Systems.

    Science.gov (United States)

    Velez-Vega, Camilo; Gilson, Michael K

    2012-03-13

    The field of host-guest chemistry provides computationally tractable yet informative model systems for biomolecular recognition. We applied molecular dynamics simulations to study the forces and mechanical stresses associated with forced dissociation of aqueous cucurbituril-guest complexes with high binding affinities. First, the unbinding transitions were modeled with constant velocity pulling (steered dynamics) and a soft spring constant, to model atomic force microscopy (AFM) experiments. The computed length-force profiles yield rupture forces in good agreement with available measurements. We also used steered dynamics with high spring constants to generate paths characterized by a tight control over the specified pulling distance; these paths were then equilibrated via umbrella sampling simulations and used to compute time-averaged mechanical stresses along the dissociation pathways. The stress calculations proved to be informative regarding the key interactions determining the length-force profiles and rupture forces. In particular, the unbinding transition of one complex is found to be a stepwise process, which is initially dominated by electrostatic interactions between the guest's ammoniums and the host's carbonyl groups, and subsequently limited by the extraction of the guest's bulky bicyclooctane moiety; the latter step requires some bond stretching at the cucurbituril's extraction portal. Conversely, the dissociation of a second complex with a more slender guest is mainly driven by successive electrostatic interactions between the different guest's ammoniums and the host's carbonyl groups. The calculations also provide information on the origins of thermodynamic irreversibilities in these forced dissociation processes.

  13. Thermal stress analysis of space shuttle orbiter wing skin panel and thermal protection system

    Science.gov (United States)

    Ko, William L.; Jenkins, Jerald M.

    1987-01-01

    Preflight thermal stress analysis of the space shuttle orbiter wing skin panel and the thermal protection system (TPS) was performed. The heated skin panel analyzed was rectangular in shape and contained a small square cool region at its center. The wing skin immediately outside the cool region was found to be close to the state of elastic instability in the chordwise direction based on the conservative temperature distribution. The wing skin was found to be quite stable in the spanwise direction. The potential wing skin thermal instability was not severe enough to tear apart the strain isolation pad (SIP) layer. Also, the preflight thermal stress analysis was performed on the TPS tile under the most severe temperature gradient during the simulated reentry heating. The tensile thermal stress induced in the TPS tile was found to be much lower than the tensile strength of the TPS material. The thermal bending of the TPS tile was not severe enough to cause tearing of the SIP layer.

  14. Circuitry linking the global Csr and σE-dependent cell envelope stress response systems.

    Science.gov (United States)

    Yakhnin, Helen; Aichele, Robert; Ades, Sarah E; Romeo, Tony; Babitzke, Paul

    2017-09-18

    CsrA of Escherichia coli is an RNA-binding protein that globally regulates a wide variety of cellular processes and behaviors including carbon metabolism, motility, biofilm formation, and the stringent response. CsrB and CsrC are sRNAs that sequester CsrA, thereby preventing CsrA-mRNA interaction. RpoE (σ E ) is the extracytoplasmic stress response sigma factor of E. coli Previous RNA-seq studies identified rpoE mRNA as a CsrA target. Here we explored the regulation of rpoE by CsrA and found that CsrA represses rpoE translation. Gel mobility shift, footprint and toeprint studies identified three CsrA binding sites in the rpoE leader transcript, one of which overlaps the rpoE Shine-Dalgarno (SD) sequence, while another overlaps the rpoE translation initiation codon. Coupled in vitro transcription-translation experiments showed that CsrA represses rpoE translation by binding to these sites. We further demonstrate that σ E indirectly activates transcription of csrB and csrC , leading to increased sequestration of CsrA such that repression of rpoE by CsrA is reduced. We propose that the Csr system fine-tunes the σ E -dependent cell envelope stress response. We also identified a 51 amino acid coding sequence whose stop codon overlaps the rpoE start codon, and demonstrate that rpoE is translationally coupled with this upstream open reading frame (ORF51). Loss of coupling reduces rpoE translation by more than 50%. Identification of a translationally coupled ORF upstream of rpoE suggests that this previously unannotated protein may participate in the cell envelope stress response. In keeping with existing nomenclature, we name ORF51 as rseD , resulting in an operon arrangement of rseD-rpoE-rseA-rseB-rseC IMPORTANCE CsrA posttranscriptionally represses genes required for bacterial stress responses, including the stringent response, catabolite repression, and the RpoS (σ S )-mediated general stress response. We show that CsrA represses translation of rpoE , encoding the

  15. The impact of stress systems and lifestyle on dyslipidemia and obesity in anxiety and depression.

    Science.gov (United States)

    van Reedt Dortland, Arianne K B; Vreeburg, Sophie A; Giltay, Erik J; Licht, Carmilla M M; Vogelzangs, Nicole; van Veen, Tineke; de Geus, Eco J C; Penninx, Brenda W J H; Zitman, Frans G

    2013-02-01

    Dyslipidemia and obesity have been observed in persons with severe anxiety or depression, and in tricyclic antidepressant (TCA) users. This likely contributes to the higher risk of cardiovascular disease (CVD) in anxiety and depressive disorders. We aimed to elucidate whether biological stress systems or lifestyle factors underlie these associations. If so, they may be useful targets for CVD prevention and intervention. Within 2850 Netherlands Study of Depression and Anxiety (NESDA) participants, we evaluated the explaining impact of biological stress systems (i.e., the hypothalamic-pituitary-adrenal [HPA] axis, autonomic nervous system [ANS] and inflammation) and lifestyle factors (i.e., tobacco and alcohol use, and physical activity) on adverse associations of anxiety and depression severity and TCA use with high and low-density lipoprotein cholesterol, triglycerides, body mass index and waist circumference. Through linear regression analyses, percentual change (%Δ) in β was determined and considered significant when %Δ>10. The inflammatory marker C-reactive protein had the most consistent impact (explaining 14-53% of the associations of anxiety and depression severity and TCA use with lipid and obesity levels), followed by tobacco use (explaining 34-43% of the associations with lipids). The ANS mediated all associations with TCA use (explaining 32-61%). The HPA axis measures did not explain any of the associations. Increased dyslipidemia and (abdominal) obesity risk in patients with more severe anxiety disorders and depression may be partly explained by chronic low-grade inflammation and smoking. TCAs may increase metabolic risk through enhanced sympathetic and decreased parasympathetic ANS activity. That the HPA axis had no impact in our sample may reflect the possibility that the HPA axis only plays a role in acute stress situations rather than under basal conditions. Copyright © 2012 Elsevier Ltd. All rights reserved.

  16. Role of the autonomic nervous system and baroreflex in stress-evoked cardiovascular responses in rats.

    Science.gov (United States)

    Dos Reis, Daniel Gustavo; Fortaleza, Eduardo Albino Trindade; Tavares, Rodrigo Fiacadori; Corrêa, Fernando Morgan Aguiar

    2014-07-01

    Restraint stress (RS) is an experimental model to study stress-related cardiovascular responses, characterized by sustained pressor and tachycardiac responses. We used pharmacologic and surgical procedures to investigate the role played by sympathetic nervous system (SNS) and parasympathetic nervous system (PSNS) in the mediation of stress-evoked cardiovascular responses. Ganglionic blockade with pentolinium significantly reduced RS-evoked pressor and tachycardiac responses. Intravenous treatment with homatropine methyl bromide did not affect the pressor response but increased tachycardia. Pretreatment with prazosin reduced the pres