WorldWideScience

Sample records for multi-product biosynthesis factory

  1. Multi-Product Microalgae Biorefineries

    NARCIS (Netherlands)

    Lam, 't G.P.; Vermuë, M.H.; Eppink, M.H.M.; Wijffels, R.H.; Berg, van den C.

    2018-01-01

    Although microalgae are a promising biobased feedstock, industrial scale production is still far off. To enhance the economic viability of large-scale microalgae processes, all biomass components need to be valorized, requiring a multi-product biorefinery. However, this concept is still too

  2. Colorful Microbial Cell Factories

    DEFF Research Database (Denmark)

    Petersen, Pia Damm

    Yeast cell factories are powerful tools used for the production of high-value natural compounds otherwise not easily available. Many bioactive and industrially important plant secondary metabolites can be produced in yeast by engineering their biosynthetic pathways into yeast cells, as these both...... anthocyanins. Yeast cell factories present a platform to circumvent the problem of low yields of interesting molecular structures in plant tissues, as hand-picking of desired enzyme activities allows for specific biosynthesis of the precise pigment of interest, as well as choosing more stable structures...... for heterologous biosynthesis is possible. In cell factories, great improvements in yields can be achieved through molecular engineering of flux from endogenous yeast precursors, e.g. by elimination of by-product formation, and by genetic optimization of pathway components, such as fine-tuning of expression levels...

  3. Particle factories

    International Nuclear Information System (INIS)

    Schindler, Rafe

    1989-01-01

    Physicists' attention is increasingly turning to the high luminosity frontier - providing enough collisions to amass sizable numbers of rare events - to complement the traditional quest for higher energies. This month we cover three areas where projects are now being considered: Phi-factory workshop, PSI Planning for B meson factory, Tau-charm factory

  4. Particle factories

    Energy Technology Data Exchange (ETDEWEB)

    Schindler, Rafe

    1989-07-15

    Physicists' attention is increasingly turning to the high luminosity frontier - providing enough collisions to amass sizable numbers of rare events - to complement the traditional quest for higher energies. This month we cover three areas where projects are now being considered: Phi-factory workshop, PSI Planning for B meson factory, Tau-charm factory.

  5. Kinetics of improved 1,4-alpha-D-glucan glucohydrolase biosynthesis from a newly isolated Aspergillus oryzae IIB-6 and parameter significance analysis by 2-factorial design.

    Science.gov (United States)

    Fatima, Bilqees; Ali, Sikander

    2012-01-01

    Sixteen different mould cultures viz. Aspergillus, Alternaria, Arthroderma, Trichoderma, Fusarium, Penicillium, Rhizopus and Chochliobolus were isolated from the soil samples of Qatar by serial dilution method. The preliminary screening of isolates was done by selecting initial colonies showing relatively bigger zones of starch hydrolysis on nutrient agar plates. The isolates were then subjected to secondary screening by submerged fermentation (SmF). The 1,4-α-D-glucan glucohydrolase (GGH) activity ranged from 1.906-12.675 U/ml/min. The product yield was analysed in dependence of mycelial morphology, biomass level and protein content. The isolate Aspergillus oryzae llB-6 which gave maximum enzyme production was incubated in M3 medium containing 20 g/l starch, 10 g/l lactose, 8.5 g/l yeast extract, 6 g/l corn steep liquor (CSL), 1.2 g/l MgSO4.7H2O, 1.3 g/l NH4Cl, 0.6 g/l CaCl2.2H2O, pH 5 at 30±2°C and 200 rpm. On the basis of kinetic variables, notably Qp (0.058±0.01(a) U/g/h), Yp/s (0.308±0.03(ab) U/g) and qp (0.210±0.032(abc) U/g fungal biomass/h), A. oryzae IIB-6 was found to be a hyper producer of GGH (LSD 0.0345) compared to A. kawachii IIB-2. A noticeable enhancement in enzyme activity of over 30% was observed (13.917±1.01 U/ml/min) when the process parameters viz. cultural conditions (pH 5, incubation period 72 h) and nutritional requirements (6 g/l CSL, 9.5 g/l yeast extract, 10 g/l starch, 20 g/l lactose) were further optimized using a 2-factorial Plackett-Burman design. The model terms were found to be highly significant (HS, p≤0.05), indicating the potential utility of the culture (dof~3).

  6. Internet Factories

    NARCIS (Netherlands)

    Strijkers, R.J.

    2014-01-01

    This thesis contributes a novel concept for introducing new network technologies in network infrastructures. The concept, called Internet factories, describes the methodical process to create and manage application-specific networks from application programs, referred to as Netapps. An Internet

  7. Internet factories

    NARCIS (Netherlands)

    Strijkers, R.J.

    2014-01-01

    This thesis contributes a novel concept for introducing new network technologies in network infrastructures. The concept, called Internet factories, describes the methodical process to create and manage application-specific networks from application programs, referred to as Netapps. An Internet

  8. Factory physics

    CERN Document Server

    Hopp, Wallace J.

    2011-01-01

    After a brief introductory chapter, "Factory Physics 3/e" is divided into three parts: I - The Lessons of History; II - Factory Physics; and III - Principles in Practice. The scientific approach to manufacturing and supply chain management, developed in Part II, is unique to this text. No other text or professional book provides a rigorous, principles-based foundation for manufacturing management. The Third Edition offers tighter connections between Lean Manufacturing, MRP/ERP, Six Sigma, Supply Chain Management, and Factory Physics. In addition to enhancing the historical overview of how these systems evolved, the authors show explicitly how users can achieve Lean Manufacturing objectives (faster response, less inventory) using the integration aspects of MRP/ERP/SCM systems along with the variance analysis methods of Six Sigma. Factory Physics provides the overarching framework that coordinates all of these initiatives into a single-focused strategy.

  9. Baby Factory

    African Journals Online (AJOL)

    Prof

    2018-01-24

    Jan 24, 2018 ... mass media have the power to easily propagate ideas on social change ... issue of 'baby factory' is becoming everyday news affecting the right of ... according to recent mass media reports, teenage girls and young women are.

  10. Neutrino Factory

    CERN Document Server

    Bogomilov, M; Tsenov, R; Dracos, M; Bonesini, M; Palladino, V; Tortora, L; Mori, Y; Planche, T; Lagrange, J  B; Kuno, Y; Benedetto, E; Efthymiopoulos, I; Garoby, R; Gilardoini, S; Martini, M; Wildner, E; Prior, G; Blondel, A; Karadzhow, Y; Ellis, M; Kyberd, P; Bayes, R; Laing, A; Soler, F  J  P; Alekou, A; Apollonio, M; Aslaninejad, M; Bontoiu, C; Jenner, L  J; Kurup, A; Long, K; Pasternak, J; Zarrebini, A; Poslimski, J; Blackmore, V; Cobb, J; Tunnell, C; Andreopoulos, C; Bennett, J  R  J; Brooks, S; Caretta, O; Davenne, T; Densham, C; Edgecock, T  R; Fitton, M; Kelliher, D; Loveridge, P; McFarland, A; Machida, S; Prior, C; Rees, G; Rogers, C; Rooney, M; Thomason, J; Wilcox, D; Booth, C; Skoro, G; Back, J  J; Harrison, P; Berg, J  S; Fernow, R; Gallardo, J  C; Gupta, R; Kirk, H; Simos, N; Stratakis, D; Souchlas, N; Witte, H; Bross, A; Geer, S; Johnstone, C; Mokhov, N; Neuffer, D; Popovic, M; Strait, J; Striganov, S; Morfín, J  G; Wands, R; Snopok, P; Bogacz, S  A; Morozov, V; Roblin, Y; Cline, D; Ding, X; Bromberg, C; Hart, T; Abrams, R  J; Ankenbrandt, C  M; Beard, K  B; Cummings, M  A  C; Flanagan, G; Johnson, R  P; Roberts, T  J; Yoshikawa, C  Y; Graves, V  B; McDonald, K  T; Coney, L; Hanson, G

    2014-01-01

    The properties of the neutrino provide a unique window on physics beyond that described by the standard model. The study of subleading effects in neutrino oscillations, and the race to discover CP-invariance violation in the lepton sector, has begun with the recent discovery that $\\theta_{13} > 0$. The measured value of $\\theta_{13}$ is large, emphasizing the need for a facility at which the systematic uncertainties can be reduced to the percent level. The neutrino factory, in which intense neutrino beams are produced from the decay of muons, has been shown to outperform all realistic alternatives and to be capable of making measurements of the requisite precision. Its unique discovery potential arises from the fact that only at the neutrino factory is it practical to produce high-energy electron (anti)neutrino beams of the required intensity. This paper presents the conceptual design of the neutrino factory accelerator facility developed by the European Commission Framework Programme 7 EURO$\

  11. Phi factories

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    Plans for 'phi factories' gathered momentum with a recent workshop at UCLA. These machines, high luminosity electron-positron colliders working near the phi resonance at 1020 MeV, have been proposed at Laboratories in Europe, the US, Japan and the USSR

  12. Smart Factory

    DEFF Research Database (Denmark)

    Bilberg, Arne; Radziwon, Agnieszka; Grube Hansen, David

    2017-01-01

    their innovation and competitive advantage by focusing at their competences, strengths and opportunities. The project suggests innovative solutions and business models through collaboration and use of new technologies. In the Smart Factory, SMEs should be able to collaborate on new products, markets and production......, and to target their challenges and ensure sustainable growth and business in these enterprises. Therefore the focus of the Smart Factory project was to support the growth and sustainable development of the small and medium sized manufacturing industry in Denmark. The project focused on SMEs and how to improve......A large part of Danish Industry is based on Small and Medium Sized Enterprises (SMEs), which account for –99% of the companies in Denmark and about two third of the job positions (source: statistikbanken.dk) . That is why, it is so important also to focus research and development at SMEs...

  13. Neutrino factories

    International Nuclear Information System (INIS)

    Dydak, F.

    2002-01-01

    The discovery of neutrino oscillations marks a major milestone in the history of neutrino physics, and opens a window to what lies beyond the Standard Model. Many current and forthcoming experiments will answer open questions; however, a major step forward, up to and possibly including CP violation in the neutrino mixing matrix, will be offered by the neutrino beams from a neutrino factory. The neutrino factory is a new concept for producing neutrino beams of unprecedented quality in terms of intensity, flavour composition, and precision of the beam parameters. These beams enable the exploration of otherwise inaccessible domains in neutrino oscillation physics by exploiting baselines of planetary dimensions. Suitable detectors pose formidable challenges but seem within reach with only moderate extrapolations from existing technologies. Although the main physics attraction of the neutrino factory is in the area of neutrino oscillations, an interesting spectrum of further opportunities ranging from high-precision, high-rate neutrino scattering to physics with high-intensity stopped muons comes with it

  14. Meson factories

    International Nuclear Information System (INIS)

    Dicello, J.F.; Zaider, M.; Bradbury, J.N.

    1979-01-01

    Technological improvements in accelerator design in the 1960's resulted in the capability to develop medium-energy proton accelerators with beam intensities of almost 1 mA. These beams are able to produce fluxes of secondary particles, including pions, muons, neutrinos, and neutrons, which are as much as 10,000 times as intense as those previously available. Those machines built for optimum meson production are commonly called meson factories. The characteristics of these facilities are reviewed, and the present programs in applied research, and some potential areas of future work are discussed

  15. Kaon factories

    International Nuclear Information System (INIS)

    Craddock, M.K.

    1983-03-01

    Kaon factories would provide beams 100-1000 times more intense than those available from present accelerators in the 10-30 GeV range. More intense or cleaner secondary beams of kaons, antiprotons and neutrinos would be of particular interest for high precision experiments and studies of rare processes in both particle and nuclear physics, e.g. symmetry violations in K-decay, neutrino scattering, meson and baryon spectroscopy, hypernuclei, exotic atoms, K + studies of nuclear density and resonance propagation in nuclei. The various accelerators proposed include both fast-cycling synchrotrons providing 100 μA proton beams at 15 to 32 GeV and superconducting isochronous ring cyclotrons giving 100-400 μA at up to 15 GeV. This paper describes these designs and the various technical problems associated with them

  16. KAON factories

    International Nuclear Information System (INIS)

    Craddock, M.K.

    1989-09-01

    Proposals for high intensity proton synchrotrons (typically providing 100 μA (6 x 10 14 p/s)) at 30 GeV have been made in Canada, Europe, Japan, the USA and the USSR. These beams would be roughly 100 times more intense than those available now and would yield equivalent increases in the fluxes of secondary particles (kaons, pions, muons, antiprotons, hyperons and neutrinos) - or cleaner beams for a smaller increase in flux. The ability to investigate rare processes on the precision frontier opens new avenues to fundamental questions in both particle and nuclear physics, complementary to traditional approaches via the energy frontier. The demand for higher currents has led to novel features in many of the accelerator designs: asymmetric magnet cycles, avoidance of transition crossing, separate collector and stretcher rings, three-dimensional beam painting at injection, bucket-to-bucket beam transfer, perpendicular biassing of microwave ferrite in the rf tuners, the use of Siberian Snakes to preserve polarization, and the addition of a pre-septum to make slow extraction >99.8% efficient. Other characteristic features include rapid cycling rates, booster stages, H - injection, low impedance enclosures, powerful feedback systems for control of beam instabilities and beam loading, and local collimation systems for handling beam loss. This paper reviews the general features of kaon factory accelerator design and the status of the various proposals

  17. Solution Method of Multi-Product Two-Stage Logistics Problem with Constraints of Delivery Course

    Science.gov (United States)

    Ataka, Shinichiro; Gen, Mitsuo

    The logistics network design is one of the important phase of Supply Chain Management (SCM) and it is the problem that should be optimized for long-term promotion of efficiency of the whole supply chain. Usually a plant produces different type of products. Even if it is a factory of the same company, delivery is different by a kind of a produced product. The restrictions which this model has are deeply concerned with TP in the real world. In this paper, we consider the logistics network design problems with multi-products and constraints for delivery course. To solve the problem, we used a hybrid priority-based Genetic Algorithm (h-priGA), and we tried the comparison experiment with priority-based Genetic Algorithm (priGA)and h-priGA, we show it about the effectiveness of h-priGA.

  18. Fractional factorial plans

    CERN Document Server

    Dey, Aloke

    2009-01-01

    A one-stop reference to fractional factorials and related orthogonal arrays.Presenting one of the most dynamic areas of statistical research, this book offers a systematic, rigorous, and up-to-date treatment of fractional factorial designs and related combinatorial mathematics. Leading statisticians Aloke Dey and Rahul Mukerjee consolidate vast amounts of material from the professional literature--expertly weaving fractional replication, orthogonal arrays, and optimality aspects. They develop the basic theory of fractional factorials using the calculus of factorial arrangements, thereby providing a unified approach to the study of fractional factorial plans. An indispensable guide for statisticians in research and industry as well as for graduate students, Fractional Factorial Plans features: * Construction procedures of symmetric and asymmetric orthogonal arrays. * Many up-to-date research results on nonexistence. * A chapter on optimal fractional factorials not based on orthogonal arrays. * Trend-free plans...

  19. The expanding universe of alkaloid biosynthesis.

    Science.gov (United States)

    De Luca, V; Laflamme, P

    2001-06-01

    Characterization of many of the major gene families responsible for the generation of central intermediates and for their decoration, together with the development of large genomics and proteomics databases, has revolutionized our capability to identify exotic and interesting natural-product pathways. Over the next few years, these tools will facilitate dramatic advances in our knowledge of the biosynthesis of alkaloids, which will far surpass that which we have learned in the past 50 years. These tools will also be exploited for the rapid characterization of regulatory genes, which control the development of specialized cell factories for alkaloid biosynthesis.

  20. Multi-Product Microalgae Biorefineries: From Concept Towards Reality.

    Science.gov (United States)

    't Lam, G P; Vermuë, M H; Eppink, M H M; Wijffels, R H; van den Berg, C

    2018-02-01

    Although microalgae are a promising biobased feedstock, industrial scale production is still far off. To enhance the economic viability of large-scale microalgae processes, all biomass components need to be valorized, requiring a multi-product biorefinery. However, this concept is still too expensive. Typically, downstream processing of industrial biotechnological bulk products accounts for 20-40% of the total production costs, while for a microalgae multi-product biorefinery the costs are substantially higher (50-60%). These costs are high due to the lack of appropriate and mild technologies to access the different product fractions such as proteins, carbohydrates, and lipids. To reduce the costs, simplified processes need to be developed for the main unit operations including harvesting, cell disruption, extraction, and possibly fractionation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Cell Factory Engineering

    DEFF Research Database (Denmark)

    Davy, Anne Mathilde; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam

    2017-01-01

    focused on individual strategies or cell types, but collectively they fall under the broad umbrella of a growing field known as cell factory engineering. Here we condense >130 reviews and key studies in the art into a meta-review of cell factory engineering. We identified 33 generic strategies......-review provides general strategy guides for the broad range of applications of rational engineering of cell factories....

  2. PCs in the factory

    CERN Document Server

    2013-01-01

    Please note this is a short discount publication.PCs have become as essential to the factory environment as they are to the office environment. This in-depth report examines how specially adapted PCs and peripherals are being established in Factory Process Control and Reporting. The report covers: * Hardware and Software* Typical Applications* Implementation Issues* Case Studies and Real Applications

  3. Robustness analysis of pull strategies in multi-product systems

    Directory of Open Access Journals (Sweden)

    Chukwunonyelum Emmanuel Onyeocha

    2015-09-01

    Full Text Available Purpose: This paper examines the behaviour of shared and dedicated Kanban allocation policies of Hybrid Kanban-CONWIP and Basestock-Kanban-CONWIP control strategies in multi-product systems; with considerations to robustness of optimal solutions to environmental and system variabilities. Design/methodology/approach: Discrete event simulation and evolutionary multi-objective optimisation approach were utilised to develop Pareto-frontier or sets of non-dominated optimal solutions and for selection of an appropriate decision set for the control parameters in the shared Kanban allocation policy (S-KAP and dedicated Kanban allocation policy (D-KAP. Simulation experiments were carried out via ExtendSim simulation application software. The outcomes of PCS+KAP performances were compared via all pairwise comparison and Nelson’s screening and selection procedure for superior PCS+KAP under negligible environmental and system stability. To determine superior PCS+KAP under systems’ and environmental variability, the optimal solutions were tested for robustness using Latin hypercube sampling technique and stochastic dominance test. Findings: The outcome of this study shows that under uncontrollable environmental variability, dedicated Kanban allocation policy outperformed shared Kanban allocation policy in serial manufacturing system with negligible and in complex assembly line with setup times. Moreover, the BK-CONWIP is shown as superior strategy to HK-CONWIP. Research limitations/implications: Future research should be conducted to verify the level of flexibility of BK-CONWIP with respect to product mix and product demand volume variations in a complex multi-product system Practical implications: The outcomes of this work are applicable to multi-product manufacturing industries with significant setup times and systems with negligible setup times. The multi-objective optimisation provides decision support for selection of control-parameters such that

  4. Towards energy transparent factories

    CERN Document Server

    Posselt, Gerrit

    2016-01-01

    This monograph provides a methodological approach for establishing demand-oriented levels of energy transparency of factories. The author presents a systematic indication of energy drivers and cost factors, taking into account the interdependencies between facility and production domains. Particular attention is given to energy flow metering and monitoring. Readers will also be provided with an in-depth description of a planning tool which allows for systematically deriving suitable metering points in complex factory environments. The target audience primarily comprises researchers and experts in the field of factory planning, but the book may also be beneficial for graduate students.

  5. Planned Positron Factory project

    International Nuclear Information System (INIS)

    Okada, Sohei

    1990-01-01

    The Japan Atomic Energy Research Institute, JAERI, has started, drafting a construction plan for the 'Positron Factory', in which intense energy-controllable monoenergetic positron beams are produced from pair-production reactions caused by high-energy electrons from a linac. The JAERI organized a planning committee to provide a basic picture for the Positron Factory. This article presents an overview of the interactions of positrons, intense positron sources and the research program and facilities planned for the project. The interactions of positrons and intense positron sources are discussed focusing on major characteristics of positrons in different energy ranges. The research program for the Positron Factory is then outlined, focusing on advanced positron annihilation techniques, positron spectroscopy (diffraction, scattering, channeling, microscopy), basic positron physics (exotic particle science), and positron beam technology. Discussion is also made of facilities required for the Positron Factory. (N.K.)

  6. Virtual Factory Testbed

    Data.gov (United States)

    Federal Laboratory Consortium — The Virtual Factory Testbed (VFT) is comprised of three physical facilities linked by a standalone network (VFNet). The three facilities are the Smart and Wireless...

  7. TRIUMF kaon factory plans

    International Nuclear Information System (INIS)

    Blackmore, E.W.

    1983-01-01

    A progress report on the TRIUMF Kaon Factory Feasibility Study is presented. The requirements placed on the machine parameters and experimental facilities by the potentially interesting experiments are discussed

  8. TRIUMF kaon factory plans

    International Nuclear Information System (INIS)

    Blackmore, E.W.

    1982-11-01

    A progress report on the TRIUMF Kaon Factory Feasibility Study is presented. The requirements placed on the machine parameters and experimental facilities by the potentially interesting experiments are discussed

  9. Super B Factories

    Indian Academy of Sciences (India)

    B factory; CP violation; B meson; supersymmetry. PACS Nos 11.30.Hv; 11.30.Pb; 12.15.Hh; 12.15.Mm; 13.20.He; 13.20.Fc;. 13.35.Dx; 14.65.Fy. 1. Introduction. The two asymmetric B factories, PEP-II and KEK-B, and their companion detec- tors, BABAR and Belle, have produced a wealth of flavor physics results, subjecting.

  10. Sustainable Multi-Product Seafood Production Planning Under Uncertainty

    International Nuclear Information System (INIS)

    Simanjuntak, Ruth; Mawengkang, Herman; Sembiring, Monalisa; Sinaga, Rani; Pakpahan, Endang J

    2013-01-01

    A multi-product fish production planning produces simultaneously multi fish products from several classes of raw resources. The goal in sustainable production planning is to meet customer demand over a fixed time horizon divided into planning periods by optimizing the tradeoff between economic objectives such as production cost, waste processed cost, and customer satisfaction level. The major decisions are production and inventory levels for each product and the number of workforce in each planning period. In this paper we consider the management of small scale traditional business at North Sumatera Province which performs processing fish into several local seafood products. The inherent uncertainty of data (e.g. demand, fish availability), together with the sequential evolution of data over time leads the sustainable production planning problem to a nonlinear mixed-integer stochastic programming model. We use scenario generation based approach and feasible neighborhood search for solving the model.

  11. Tau-charm factory..

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1995-10-15

    In addition to hearing the latest experimental and theoretical developments at the 17th International Symposium on Lepton Photon Interactions in Beijing, delegates were brought up-to-date on the substantial progress towards the realization of a Tau-Charm Factory in the Chinese capital. Opening the Symposium, Zhou Guangzhao, President of the Chinese Academy of Sciences, expressed a commitment of the Chinese government to basic research and its interest in the continuing development high energy physics in China. Following the very successful construction and operation of Beijing's Electron-Positron Collider, BEPC, the Chinese government has provided 5M yuan ($US 600,000) for a feasibility study by the end of 1996 for a Tau-Charm Factory at Beijing's Institute of High Energy Physics (IHEP). Professor Zhou expressed his belief that, once approved, such a factory would greatly enhance high energy physics in China. He warmly welcomed international collaboration both in the construction of the accelerator and in the experimental programme. His comments were reinforced in the following welcome speech by IHEP Director Zheng Zhipeng. Conference delegates had the opportunity to inspect the BEPC injector and collider, built almost entirely by Chinese industry. The International Committee for Future Accelerators (ICFA) met during the Symposium, with Tau- Charm Factory business on the agenda. In his subsequent report, ICFA Chairman John Peoples said that a Tau-Charm Factory provides a unique experimental environment for the precision studies of tau, charm and light quark-gluon spectroscopy, and that some issues in these fields are not satisfactorily addressed solely by B Factories or fixed-target experiments. The committee expressed a strong interest in seeing a Tau-Charm Factory built and noted the serious interest, especially in China, and looks forward to operation and exploitation by the international physics community. In their Beijing summary talks, both Sam Ting and T

  12. Tau-charm factory..

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    In addition to hearing the latest experimental and theoretical developments at the 17th International Symposium on Lepton Photon Interactions in Beijing, delegates were brought up-to-date on the substantial progress towards the realization of a Tau-Charm Factory in the Chinese capital. Opening the Symposium, Zhou Guangzhao, President of the Chinese Academy of Sciences, expressed a commitment of the Chinese government to basic research and its interest in the continuing development high energy physics in China. Following the very successful construction and operation of Beijing's Electron-Positron Collider, BEPC, the Chinese government has provided 5M yuan ($US 600,000) for a feasibility study by the end of 1996 for a Tau-Charm Factory at Beijing's Institute of High Energy Physics (IHEP). Professor Zhou expressed his belief that, once approved, such a factory would greatly enhance high energy physics in China. He warmly welcomed international collaboration both in the construction of the accelerator and in the experimental programme. His comments were reinforced in the following welcome speech by IHEP Director Zheng Zhipeng. Conference delegates had the opportunity to inspect the BEPC injector and collider, built almost entirely by Chinese industry. The International Committee for Future Accelerators (ICFA) met during the Symposium, with Tau- Charm Factory business on the agenda. In his subsequent report, ICFA Chairman John Peoples said that a Tau-Charm Factory provides a unique experimental environment for the precision studies of tau, charm and light quark-gluon spectroscopy, and that some issues in these fields are not satisfactorily addressed solely by B Factories or fixed-target experiments. The committee expressed a strong interest in seeing a Tau-Charm Factory built and noted the serious interest, especially in China, and looks forward to operation and exploitation by the international physics community. In their Beijing summary talks, both Sam Ting

  13. The Smart Factory

    DEFF Research Database (Denmark)

    Radziwon, Agnieszka; Bilberg, Arne; Bogers, Marcel

    2014-01-01

    Nowadays we live in a world, which a decade ago would only be described in the science fiction literature. More and more things become smart and both scientists and engineers strive for developing not only new and innovative devices, but also homes, factories, or even cities. Despite of continuous...... development, many of those concepts are still being just a vision of the future, which still needs a lot of effort to become true. This paper reviews the usage of adjective smart in respect to technology and with a special emphasis on the smart factory concept placement among contemporary studies. Due...... to a lack of a consensus of common understanding of this term, a unified definition is proposed. The conceptualization will not only refer to various smart factory visions reported in the literature, but also link the crucial characteristics of this emerging manufacturing concept to usual manufacturing...

  14. B-factory detectors

    International Nuclear Information System (INIS)

    Marlow, D.R.

    2002-01-01

    The designs of the recently commissioned BaBar and Belle B-Factory detectors are described. The discussion is organized around the methods and instruments used to detect the so-called gold-plated-mode B 0 →J/ΨK S decays and related modes

  15. Factorial Analysis of Profitability

    OpenAIRE

    Georgeta VINTILA; Ilie GHEORGHE; Ioana Mihaela POCAN; Madalina Gabriela ANGHEL

    2012-01-01

    The DuPont analysis system is based on decomposing the profitability ratio in factors of influence. This paper describes the factorial analysis of profitability based on the DuPont system. Significant importance is given to the impact on various indicators on the shares value and profitability.

  16. The Clone Factory

    Science.gov (United States)

    Stoddard, Beryl

    2005-01-01

    Have humans been cloned? Is it possible? Immediate interest is sparked when students are asked these questions. In response to their curiosity, the clone factory activity was developed to help them understand the process of cloning. In this activity, students reenact the cloning process, in a very simplified simulation. After completing the…

  17. Four-legged factories

    International Nuclear Information System (INIS)

    Mackie, R.I.; Van der Walt, J.G.

    1982-01-01

    Insight into how ruminants utilise plant material, converting what is essentially waste into food, wool and draught power for Man is being sought by Animal Scientists using isotopic tracer techniques. Answers to cost-effectice biological conversion lie in the complex interactions of the rumen's microbial fermentation factory and the host animal's diet and metabolism

  18. Haiti. Educating factory workers.

    Science.gov (United States)

    Hughes, H

    1990-04-01

    There are approximately 50,000 workers employed in the light assembly industry in Haiti. About 70% are women, the majority of whom are aged between 25 and 34 years, and are either single or in a nonpermanent relationship with the father of their children. Many live and work in appalling conditions, surviving on very low wages to support several children and an extended family. The acquired immunodeficiency syndrome (AIDS) is now a visible problem in many factories. In October 1988, the Center for the Promotion of Women Workers (Centre de Promotion des Femmes Ouvriers/CPFO) launched a pilot AIDS education program for factory women. The Center, based in a large industrial zone near the airport, runs a health clinic and courses in literacy, communications skills, health promotion and family planning. The new AIDS program allowed CPFO staff to gain entry into factories for the 1st time. Other courses were held outside working hours and outside factory premises. Staff contacted manages by telephone to arrange a meeting to discuss AIDS and to ask permission to hold educational "round tables" with workers. Of 18 managers in the factories approached over a 12-month period, only 2 refused entry to CPFO staff. Almost all managers reported they had registered between 2 and 5 deaths from AIDS among their employees over the past couple of years. A total of 85 educational sessions, each lasting about 2 hours, were held within 28 different factories, community or labor organizations reaching 3063 workers (male and female). In each session, the presentation was carried out by 2 CPFO trained monitors and included a slide show, flip charts, and the video "Met ko," originally produced for Haitian immigrants in New York. The most important aspect of the program was the training of 38 volunteer factory-based health promoters. These promoters attended the round table sessions, where they facilitated discussion and distributed condoms and were subsequently available for counseling co

  19. Multi-Product Crops for Agricultural and Energy Production : an AGE Analysis for Poland

    NARCIS (Netherlands)

    Ignaciuk, A.; Dellink, R.B.

    2005-01-01

    By-products from agriculture and forestry can contribute to production of clean and cheap (bio)electricity. To assess the role of such multi-product crops in the response to climate policies, we present an applied general equilibrium model with special attention to biomass and multi-product crops

  20. Virtual Learning Factory on VR-Supported Factory Planning

    OpenAIRE

    Weidig , Christian; Menck , Nicole; Winkes , Pascal ,; Aurich , Jan ,

    2014-01-01

    Part 13: Virtual Reality and Simulation; International audience; Learning Factories are becoming popular as tangible measures to teach engineering methods while making use of them in an industrial-like environment. Their core component is usually a factory demonstrator, users are physically working with. For factory planning such approaches can hardly be adapted, due to long lasting realization phases.To overcome this obstacle a virtual learning factory has been developed whose core component...

  1. Review of kaon factory proposals

    International Nuclear Information System (INIS)

    Thiessen, H.A.

    1985-01-01

    Nuclear physics issues and particle physics issues for a kaon factory are discussed. Kaon factory accelerator proposals are then considered. Secondary beam considerations are covered and hardware development for a kaon factory is discussed. The prospects for construction are presented. 9 refs., 12 figs., 2 tabs

  2. Superconducting cavities for beauty factories

    International Nuclear Information System (INIS)

    Lengeler, H.

    1992-01-01

    The possibilities and merits of superconducting accelerating cavities for Beauty-factories are considered. There exist already large sc systems of size and frequency comparable to the ones needed for Beauty-factories. Their status and operation experience is discussed. A comparison of normal conducting and superconducting systems is done for two typical Beauty-factory rings

  3. Hazardous factories: Nigerian evidence.

    Science.gov (United States)

    Oloyede, Olajide

    2005-06-01

    The past 15 years have seen an increasing governmental and corporate concern for the environment worldwide. For governments, information about the environmental performance of the industrial sector is required to inform macro-level decisions about environmental targets such as those required to meet UN directives. However, in many African, Asian, and Latin American countries, researching and reporting company environmental performance is limited. This article serves as a contribution to filling the gap by presenting evidence of physical and chemical risk in Nigerian factories. One hundred and three factories with a total of 5,021 workers were studied. One hundred and twenty physical and chemical hazards were identified and the result shows a high number of workers exposed to such hazards. The study also reveals that workers' awareness level of chemical hazards was high. Yet the danger was perceived in behavioral terms, especially by manufacturing firms, which tend to see environmental investment in an increasingly global economy as detrimental to profitability.

  4. Engineering the smart factory

    Science.gov (United States)

    Harrison, Robert; Vera, Daniel; Ahmad, Bilal

    2016-10-01

    The fourth industrial revolution promises to create what has been called the smart factory. The vision is that within such modular structured smart factories, cyber-physical systems monitor physical processes, create a virtual copy of the physical world and make decentralised decisions. This paper provides a view of this initiative from an automation systems perspective. In this context it considers how future automation systems might be effectively configured and supported through their lifecycles and how integration, application modelling, visualisation and reuse of such systems might be best achieved. The paper briefly describes limitations in current engineering methods, and new emerging approaches including the cyber physical systems (CPS) engineering tools being developed by the automation systems group (ASG) at Warwick Manufacturing Group, University of Warwick, UK.

  5. The TRIUMF KAON Factory

    International Nuclear Information System (INIS)

    Craddock, M.

    1989-05-01

    TRIUMF has been awarded $11M for a one-year pre-construction Engineering Design and Impact Study of the KAON Factory. This will enable prototypes of many accelerator components to be built and the design of the accelerators and the layout of the experimental areas to be reviewed. The building and tunnel designs will be finalized, environmental, legal and economic impact studies carried out, and international involvement pursued further

  6. Automation in the factory

    Energy Technology Data Exchange (ETDEWEB)

    Hatvany, J

    1984-05-01

    There are now about 100000 computers in the manufacturing plants of the world, but the thirty-year old dream of the computer-controlled factory is only now beginning to materialize. With the advent of advanced microprocessor technology of distributed systems based on local area networking and of supervisory and diagnostic systems utilizing artificial intelligence techniques, computer-integrated manufacturing (CIM) has today become a realistic aim. 6 references.

  7. SLAC B Factory computing

    International Nuclear Information System (INIS)

    Kunz, P.F.

    1992-02-01

    As part of the research and development program in preparation for a possible B Factory at SLAC, a group has been studying various aspects of HEP computing. In particular, the group is investigating the use of UNIX for all computing, from data acquisition, through analysis, and word processing. A summary of some of the results of this study will be given, along with some personal opinions on these topics

  8. TRIUMF: Kaon factory physics

    International Nuclear Information System (INIS)

    Anon.

    1982-01-01

    The second TRIUMF Kaon Factory Physics Workshop was held on 10-14 August, 1981. About a hundred physicists participated in the meeting, which consisted of fifteen invited talks and four afternoon workshop sessions, and proved to be a stimulating and productive event. The discussions centred on identifying the most important physics that could be studied with a machine providing an increase in intensity of two orders of magnitude in primary proton beam over present accelerators in the energy range 8 to 20 GeV, and on establishing some preliminary guidelines on the desirable properties of secondary beams at such a machine

  9. KEK: B factory plans

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    To boost the study of B mesons (carrying the heavy b quark), the Japanese KEK Laboratory is looking to construct a B-meson 'factory'. B-mesons have revealed unexpected and important quark physics. Well-known examples are the long lifetime of the B-mesons, indicating a large gap between the third and second quark generation (compared to that between the second and the first), and relatively large mixing of the neutral B-meson and its antiparticle, now interpreted as being due to a heavy sixth ('top') quark

  10. Deciding WQO for factorial languages

    KAUST Repository

    Atminas, Aistis; Lozin, Vadim V.; Moshkov, Mikhail

    2013-01-01

    A language is factorial if it is closed under taking factors (i.e. contiguous subwords). Every factorial language can be described by an antidictionary, i.e. a minimal set of forbidden factors. We show that the problem of deciding whether a factorial language given by a finite antidictionary is well-quasi-ordered under the factor containment relation can be solved in polynomial time. © 2013 Springer-Verlag Berlin Heidelberg.

  11. Deciding WQO for factorial languages

    KAUST Repository

    Atminas, Aistis

    2013-04-05

    A language is factorial if it is closed under taking factors (i.e. contiguous subwords). Every factorial language can be described by an antidictionary, i.e. a minimal set of forbidden factors. We show that the problem of deciding whether a factorial language given by a finite antidictionary is well-quasi-ordered under the factor containment relation can be solved in polynomial time. © 2013 Springer-Verlag Berlin Heidelberg.

  12. KEK: B factory

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    After more than three years of intensive evaluation, the Japanese government has approved the conversion of the TRISTAN electronpositron collider at the national KEK Laboratory to a two-ring asymmetric B-meson factory. The project will take about five years to complete. Initial construction will proceed while TRISTAN experiments continue datataking, expected to continue until summer 1995. When it becomes operational in 1998, the new facility (TRISTAN II) will be capable of producing more than ten million B meson pairs each year. Detailed studies of their decay properties are expected to reveal answers to the long-standing puzzle of the violation of CP symmetry - combined left-right reversal and particle-antiparticle substitution

  13. SRF for neutrino factories

    International Nuclear Information System (INIS)

    Padamsee, H.

    2003-01-01

    The Neutrino Factory calls for nearly 500 meters of 200 MHz SRF cavities to provide 7.5 GV. Such a facility is more demanding than the largest SRF installation to date, i.e., LEP-II, where 500 m of niobium-coated copper cavities provided more than 3 GV of acceleration. Based on the high real estate gradient desired to minimize muon loss, superconducting cavities are selected to provide active gradients of 15 - 17 MV/m, and a real estate gradient of 7.5 MV/m. At such high gradients, the peak RF power demand for copper cavities would become prohibitively expensive. By virtue of low losses, SC cavities can be filled slowly (rise time 3 ms) reducing the peak power demand to roughly half MW per cell. (author)

  14. Positron Factory project

    Energy Technology Data Exchange (ETDEWEB)

    Okada, Sohei; Sunaga, Hiromi; Kaneko, Hirohisa; Kawasuso, Atsuo; Masuno, Shin-ichi; Takizawa, Haruki; Yotsumoto, Keiichi [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

    1997-03-01

    We have started drafting a construction program for the Positron Factory, in which linac-based intense monoenergetic positron beams are planned to be applied for materials science, biotechnology and basic physics and chemistry. A technical survey study confirmed the feasibility of manufacturing a dedicated electron linac of 100 kW class with a beam energy of 100 MeV, which will produce a world-highest monoenergetic positron beam of more than 10{sup 10}/sec in intensity. A self-driven rotating converter (electrons to positrons and photons) suitable for the high power electron beam was devised and successfully tested. The practicability of simultaneous extraction of multi-channel monoenergetic positron beams with multiple moderator assemblies, which had been originated on the basis of a Monte Carlo simulation, was demonstrated by an experiment using an electron linac. An efficient moderator structure, which is composed of honeycomb-like assembled moderator foils and reflectors, is also proposed. (author)

  15. General B factory design considerations

    International Nuclear Information System (INIS)

    Zisman, M.S.

    1992-12-01

    We describe the general considerations that go into the design of an asymmetric B factory collider. Justification is given for the typical parameters of such a facility, and the physics and technology challenges that arise from these parameter choices are discussed. Cost and schedule issues for a B factory are discussed briefly. A summary of existing proposals is presented, noting their similarities and differences

  16. Biosynthesis of tylophora alkaloids

    International Nuclear Information System (INIS)

    Mulchandani, N.B.; Iyer, S.S.; Badheka, L.P.

    1974-01-01

    Using labelled precursors, biosynthesis of the tylophora alkaloids, tylophorine, tylophorinidine and tylophorinide has been investigated in Tylophora asthmatica plants. The radioactive precursors, phenylalanine-2- 14 C, benzoic acid-1- 14 C, benzoic acid-ring 14 C, acetate-2- 14 C, ornithine-5- 14 C, acetate-2- 14 C, ornithine-5- 14 C and cinnamic acid-2- 14 C were administered to the plants individually by wick technique. Tylophorine was isolated in each case and assayed for its radioactivity to find out the incorporation of the label into it. The results indicate that: (1) phenylalanine via cinnamic acid is an important precursor in the biosynthesis of tylophorine (2) orinithine participates in tylophorine biosynthesis via pyrroline and (3) tylophorinidine may be a direct precursor of tylophorine. (M.G.B.)

  17. The eldercare factory.

    Science.gov (United States)

    Sharkey, Noel; Sharkey, Amanda

    2012-01-01

    Rapid advances in service robotics together with dramatic shifts in population demographics have led to the notion that technology may be the answer to our eldercare problems. Robots are being developed for feeding, washing, lifting, carrying and mobilising the elderly as well as monitoring their health. They are also being proposed as a substitute for companionship. While these technologies could accrue major benefits for society and empower the elderly, we must balance their use with the ethical costs. These include a potential reduction in human contact, increased feeling of objectification and loss of control, loss of privacy and personal freedom as well as deception and infantilisation. With appropriate guidelines in place before the introduction of robots en masse into the care system, robots could improve the lives of the elderly, reducing their dependence and creating more opportunities for social interaction. Without forethought, the elderly may find themselves in a barren world of machines, a world of automated care: a factory for the elderly. Copyright © 2011 S. Karger AG, Basel.

  18. The TRIUMF KAON factory

    International Nuclear Information System (INIS)

    Craddock, M.K.

    1991-05-01

    The TRIUMF KAON Factory is designed to produce beams of kaons, antiprotons, other hadrons and neutrinos 100 times more intense, or cleaner, than are available now, for a broad range of particle and nuclear physics experiments. This will require a 100 μA beam of 30 GeV protons, to be produced by an interleaved sequence of two fast-cycling synchrotrons and three storage rings, with the existing TRIUMF H - cyclotron as injector. An $11-million preconstruction study has enabled the overall design to be reviewed and prototypes of various components to be built and evaluated -fast-cycling dipole and quadrupole magnets, a dual-frequency magnet power supply, ceramic beam pipes with internal RF shields, an RF cavity (using perpendicular bias), an extraction kicker, and RF beam chopper, and production targets. Environmental, industrial and economic impact studies have also been completed and the cost estimates and schedule updated. The total cost of $708 million (Canadian) will be shared equally between Canada, British Columbia (already approved) and international contributors. The federal decision is expected shortly. (Author) 29 refs., 5 figs

  19. The TRIUMF KAON Factory

    International Nuclear Information System (INIS)

    Craddock, M.K.

    1990-11-01

    The TRIUMF KAON Factory is designed to produce beams of kaons, antiprotons, other hadrons and neutrinos 100 times more intense, or cleaner, than are available now, for a broad range of experiments in particle and nuclear physics. This will require a 100 μA beam of 30 GeV protons, to be produced by an interleaved sequence of two fast-cycling synchrotrons and three storage rings, with the existing TRIUMF H - cyclotron as injector. An $11-million preconstruction study has enabled the overall design to be reviewed and prototypes of various accelerator components to be built and evaluated. Environmental, industrial and economic impact studies have also been completed. Payment of one-third of the total cost of $708 million (Canadian) has been approved by the government of British Columbia; a further third is expected from international sources, on the basis of inter-governmental consultations. A decision on the final third is expected from the government of Canada before the end of 1990. (Author) (15 refs., 7 figs.)

  20. The nearby supernova factory

    International Nuclear Information System (INIS)

    Wood-Vasey, W.M.; Aldering, G.; Lee, B.C.; Loken, S.; Nugent, P.; Perlmutter, S.; Siegrist, J.; Wang, L.; Antilogus, P.; Astier, P.; Hardin, D.; Pain, R.; Copin, Y.; Smadja, G.; Gangler, E.; Castera, A.; Adam, G.; Bacon, R.; Lemonnier, J.-P.; Pecontal, A.; Pecontal, E.; Kessler, R.

    2004-01-01

    The Nearby Supernova Factory (SNfactory) is an ambitious project to find and study in detail approximately 300 nearby Type Ia supernovae (SNe Ia) at redshifts 0.03 < z < 0.08. This program will provide an exceptional data set of well-studied SNe in the nearby smooth Hubble flow that can be used as calibration for the current and future programs designed to use SNe to measure the cosmological parameters. The first key ingredient for this program is a reliable supply of Hubble-flow SNe systematically discovered in unprecedented numbers using the same techniques as those used in distant SNe searches. In 2002, 35 SNe were found using our test-bed pipeline for automated SN search and discovery. The pipeline uses images from the asteroid search conducted by the Near Earth Asteroid Tracking group at JPL. Improvements in our subtraction techniques and analysis have allowed us to increase our effective SN discovery rate to ∼12 SNe/month in 2003

  1. AutoPyFactory: A Scalable Flexible Pilot Factory Implementation

    International Nuclear Information System (INIS)

    Caballero, J; Hover, J; Love, P; Stewart, G A

    2012-01-01

    The ATLAS experiment at the CERN LHC is one of the largest users of grid computing infrastructure, which is a central part of the experiment's computing operations. Considerable efforts have been made to use grid technology in the most efficient and effective way, including the use of a pilot job based workload management framework. In this model the experiment submits ‘pilot’ jobs to sites without payload. When these jobs begin to run they contact a central service to pick-up a real payload to execute. The first generation of pilot factories were usually specific to a single Virtual Organization (VO), and were bound to the particular architecture of that VO's distributed processing. A second generation provides factories which are more flexible, not tied to any particular VO, and provide new and improved features such as monitoring, logging, profiling, etc. In this paper we describe this key part of the ATLAS pilot architecture, a second generation pilot factory, AutoPyFactory. AutoPyFactory has a modular design and is highly configurable. It is able to send different types of pilots to sites and exploit different submission mechanisms and queue characteristics. It is tightly integrated with the PanDA job submission framework, coupling pilot flow to the amount of work the site has to run. It gathers information from many sources in order to correctly configure itself for a site and its decision logic can easily be updated. Integrated into AutoPyFactory is a flexible system for delivering both generic and specific job wrappers which can perform many useful actions before starting to run end-user scientific applications, e.g., validation of the middleware, node profiling and diagnostics, and monitoring. AutoPyFactory also has a robust monitoring system that has been invaluable in establishing a reliable pilot factory service for ATLAS.

  2. Photon factory activity report, 1992

    International Nuclear Information System (INIS)

    1993-01-01

    This issue is the annual report of the Photon Factory, National laboratory of High Energy Physics. First, the outline of the Photon Factory is presented. Injector linac, light source, beamlines and instrumentation, the Tristan synchrotron radiation facility at the accumulation ring, and the Tristan super light facility are described in detail. The facility is open to researchers. The user's reports are collected as well. (J.P.N.) (435 refs.)

  3. Atomic Energy (factories) rules: 1988

    International Nuclear Information System (INIS)

    1988-01-01

    These rules are made by the Central Government under the Factories Act, 1948 and extend to all factories engaged in carrying out the purposes of the Atomic Energy Act, 1962. The rules cover the requirements of inspecting staff, health aspects, personnel safety, personnel welfare, working hours, employment of young persons, special provisions in case of dangerous manufacturing processes or operations, supplemental rules for administrative aspects and special powers of competent authority. (M.G.B.)

  4. Photon factory activity report, 1993

    International Nuclear Information System (INIS)

    1994-01-01

    This issue is the annual report of the Photon Factory, National Laboratory of High Energy Physics. First the outline of the Photon Factory is presented. Injector linac, light source, beamlines and instrumentation, synchrotron radiation facility at the Tristan accumulation ring, and the Tristan super light facility are described in detail. The facility is open to researchers. The user's reports are collected as well. (J.P.N.)

  5. Muon colliders and neutrino factories

    Energy Technology Data Exchange (ETDEWEB)

    Geer, S.; /Fermilab

    2010-09-01

    Over the last decade there has been significant progress in developing the concepts and technologies needed to produce, capture and accelerate {Omicron}(10{sup 21}) muons/year. This development prepares the way for a new type of neutrino source (Neutrino Factory) and a new type of very high energy lepton-antilepton collider (Muon Collider). This article reviews the motivation, design and R&D for Neutrino Factories and Muon Colliders.

  6. AutoPyFactory: A Scalable Flexible Pilot Factory Implementation

    CERN Document Server

    Caballero, J; The ATLAS collaboration; Love, P; Stewart, G

    2012-01-01

    The ATLAS experiment at the CERN LHC is one of the largest users of grid computing infrastructure, which is a central part of the experiment’s computing operations. Considerable efforts have been made to use grid technology in the most efficient and effective way, including the use of a pilot job based workload management framework. In this model the experiment submits ’pilot’ jobs to sites without payload. When these jobs begin to run they contact a central service to retrieve a real payload to execute. The first generation of pilot factories were usually specific to a single VO, and were bound to the particular architecture of that VO’s distributed processing. A second generation provides factories which are more flexible, not tied to any particular VO, and provide new or improved features such as monitoring, logging, profiling, etc. In this paper we describe this key part of the ATLAS pilot architecture, a second generation pilot factory, AutoPyFactory. AutoPyFactory has a modular design and is hig...

  7. The tau-charm factory: Experimental perspectives

    International Nuclear Information System (INIS)

    Perl, M.L.; Schindler, R.H.

    1991-09-01

    This report discusses the Tau-Charm Factory Concept; D and D S Physics at the Tau-Charm Factory; τ and ν τ Physics at the Tau-Charm Factory; and Charmonium, Gluonium and Light Quark Spectroscopy at the Tau-Charm Factory

  8. Glycopeptide antibiotic biosynthesis.

    Science.gov (United States)

    Yim, Grace; Thaker, Maulik N; Koteva, Kalinka; Wright, Gerard

    2014-01-01

    Glycopeptides such as vancomycin, teicoplanin and telavancin are essential for treating infections caused by Gram-positive bacteria. Unfortunately, the dwindled pipeline of new antibiotics into the market and the emergence of glycopeptide-resistant enterococci and other resistant bacteria are increasingly making effective antibiotic treatment difficult. We have now learned a great deal about how bacteria produce antibiotics. This information can be exploited to develop the next generation of antimicrobials. The biosynthesis of glycopeptides via nonribosomal peptide assembly and unusual amino acid synthesis, crosslinking and tailoring enzymes gives rise to intricate chemical structures that target the bacterial cell wall. This review seeks to describe recent advances in our understanding of both biosynthesis and resistance of these important antibiotics.

  9. Neutrino Factory: status and prospects

    International Nuclear Information System (INIS)

    Long, K.

    2011-01-01

    The properties of the neutrino provide a unique window on physics beyond that described by the Standard Model. The study of sub-leading effects in neutrino oscillations has begun with the race to measure θ 13 consensus is emerging within the international community that a novel neutrino source is required to allow sensitive searches for leptonic CP violation to be carried out and the neutrino mass-hierarchy to be determined. The Neutrino Factory, in which intense neutrino beams are produced from the decay of muons, has been shown to out-perform the other proposed facilities. The physics case for the Neutrino Factory will be reviewed and the baseline design of the facility being developed by the International Design Study for the Neutrino Factory (the IDS-NF) collaboration will be described.

  10. Steps towards the Neutrino Factory

    International Nuclear Information System (INIS)

    Long, K.

    2012-01-01

    The properties of the neutrino provide a unique window on physics beyond that described by the Standard Model. The study of sub-leading effects in neutrino oscillations has begun with the race to measure θ 13 . A consensus is emerging within the international community that a novel neutrino source is required to allow sensitive searches for leptonic CP violation to be carried out and the neutrino mass-hierarchy to be determined. The Neutrino Factory, in which intense neutrino beams are produced from the decay of muons, has been shown to out-perform the other proposed facilities. The physics case for the Neutrino Factory will be reviewed and the baseline design of the facility being developed by the International Design Study for the Neutrino Factory (the IDS-NF) collaboration will be described.

  11. Engineering the Polyketide Cell Factory

    DEFF Research Database (Denmark)

    Mølgaard, Louise

    sufficient titers. To improve the production of polyketides biological engineering principles have been applied for the development and engineering of microbial polyketide cell factories. The two biological hosts used for heterologous polyketide production were Aspergillus nidulans and Saccharomyces...... phosphopantetheinylase (PPTase). This versatile vector system can easily be used for expression of other polyketides of interest as well as extended to express whole gene clusters. After achieving proof of principle in terms of expression, the polyketide cell factory must be optimized. The optimization can be achieved...... characterization in bioreactors revealed that the yields of 6-MSA on biomass increased albeit not significantly. As a result of this it may be argued that there is still more work to be done in terms of model building in A. nidulans. Utilizing another well-established cell factory S. cerevisiae the capabilities...

  12. Photon Factory activity report, 1991

    International Nuclear Information System (INIS)

    1992-01-01

    The Photon Factory is a national synchrotron radiation research facility affiliated with the National Laboratory for High Energy Physics located in Tsukuba Science City. The Photon Factory consists of a 2.5 GeV electron/positron linear accelerator, a 2.5 GeV electron/positron storage ring, beam lines and experimental stations. All the facilities for synchrotron radiation research are open to scientists. A part of the accumulation ring of the TRISTAN main ring has been used as a synchrotron radiation source in the energy range from 5.8 to 6.5 GeV. The Photon Factory is composed of three divisions of Injector Linac, Light Source and Instrumentation. The researches of each divisions are reviewed, and the users' short reports are collected. The list of published papers with author index is also included in the publication. (K.I.) 233 refs

  13. Math for the digital factory

    CERN Document Server

    Hömberg, Dietmar; Landry, Chantal

    2017-01-01

    This volume provides a unique collection of mathematical tools and industrial case studies in digital manufacturing. It addresses various topics, ranging from models of single production technologies, production lines, logistics and workflows to models and optimization strategies for energy consumption in production. The digital factory represents a network of digital models and simulation and 3D visualization methods for the holistic planning, realization, control and ongoing improvement of all factory processes related to a specific product. In the past ten years, all industrialized countries have launched initiatives to realize this vision, sometimes also referred to as Industry 4.0 (in Europe) or Smart Manufacturing (in the United States). Its main goals are • reconfigurable, adaptive and evolving factories capable of small-scale production • high-performance production, combining flexibility, productivity, precision and zero defects • energy and resource efficiency in manufacturing None of these...

  14. A heuristic algorithm for a multi-product four-layer capacitated location-routing problem

    Directory of Open Access Journals (Sweden)

    Mohsen Hamidi

    2014-01-01

    Full Text Available The purpose of this study is to solve a complex multi-product four-layer capacitated location-routing problem (LRP in which two specific constraints are taken into account: 1 plants have limited production capacity, and 2 central depots have limited capacity for storing and transshipping products. The LRP represents a multi-product four-layer distribution network that consists of plants, central depots, regional depots, and customers. A heuristic algorithm is developed to solve the four-layer LRP. The heuristic uses GRASP (Greedy Randomized Adaptive Search Procedure and two probabilistic tabu search strategies of intensification and diversification to tackle the problem. Results show that the heuristic solves the problem effectively.

  15. Triterpene biosynthesis in plants.

    Science.gov (United States)

    Thimmappa, Ramesha; Geisler, Katrin; Louveau, Thomas; O'Maille, Paul; Osbourn, Anne

    2014-01-01

    The triterpenes are one of the most numerous and diverse groups of plant natural products. They are complex molecules that are, for the most part, beyond the reach of chemical synthesis. Simple triterpenes are components of surface waxes and specialized membranes and may potentially act as signaling molecules, whereas complex glycosylated triterpenes (saponins) provide protection against pathogens and pests. Simple and conjugated triterpenes have a wide range of applications in the food, health, and industrial biotechnology sectors. Here, we review recent developments in the field of triterpene biosynthesis, give an overview of the genes and enzymes that have been identified to date, and discuss strategies for discovering new triterpene biosynthetic pathways.

  16. Exponential Smoothing for Multi-Product Lot-Sizing With Heijunka and Varying Demand

    OpenAIRE

    Grimaud Frédéric; Dolgui Alexandre; Korytkowski Przemyslaw

    2014-01-01

    Here we discuss a multi-product lot-sizing problem for a job shop controlled with a heijunka box. Demand is considered as a random variable with constant variation which must be absorbed somehow by the manufacturing system, either by increased inventory or by flexibility in the production. When a heijunka concept (production leveling) is used, fluctuations in customer orders are not transferred directly to the manufacturing system allowing for a smoother production and better production capac...

  17. Urban tourist complexes as Multi-product companies: Market segmentation and product differentiation in Amsterdam

    OpenAIRE

    Romao, J.; Neuts, B.; Nijkamp, P.; Leeuwen, E.S. van

    2012-01-01

    The tourism sector is evolving into an advanced industrial sector. Modern tourism presupposes an attractive portfolio of tourist services for a varied set of visitors. Meanwhile, tourism destinations have turned into multifaceted tourist complexes comprising a broad package of amenities that satisfy the needs of a heterogeneous group of clients. Such tourist complexes may be regarded as export-oriented multi-product companies, characterized by spatial and functional market segmentation and by...

  18. Neutrino factory plans at CERN

    CERN Document Server

    Riche, J A

    2001-01-01

    The considerable interest raised by the discovery of neutrino oscillations and recent progress in studies of muon colliders has triggered interest in considering a neutrino factory at CERN. This paper explains the reference scenario, indicates the other possible choices and mentions the R&D that are foreseen.

  19. Planned e+e- factories

    International Nuclear Information System (INIS)

    Le Duff, J.

    1993-09-01

    Various Beauty and Tau-Charm factories and projects are reviewed. Different machines (TRISTAN II, PEP II, CESR-B, the Dubna project and the European project) are compared and their design and parameters are described. (K.A.) 34 refs., 2 figs., 2 tabs

  20. Factorial representations of path groups

    International Nuclear Information System (INIS)

    Albeverio, S.; Hoegh-Krohn, R.; Testard, D.; Vershik, A.

    1983-11-01

    We give the reduction of the energy representation of the group of mappings from I = [ 0,1 ], S 1 , IRsub(+) or IR into a compact semi simple Lie group G. For G = SU(2) we prove the factoriality of the representation, which is of type III in the case I = IR

  1. A Review of "Infinity Factory."

    Science.gov (United States)

    National Council of Teachers of Mathematics, Inc., Reston, VA.

    Following a discussion of the historical background of the TV series "Infinity Factory," the goals of the television project are listed. A general description of the television series, an evaluation of the entertainment value, and an evaluation of children's attitude change are briefly presented. The program's presentation of mathematics…

  2. Photon Factory Activity Report, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    Photon Factory Activity Report no.12 deals with our activities in the period from October 1993 through September 1994. We operate two light sources at the Photon Factory; the 2.5-GeV Photon Factory storage ring, which is a dedicated light source, and the 6.5-GeV TRISTAN Accumulation Ring, which is parasitically used as a light source. We keep more than seventy experimental stations at two facilities, and accept experiments primarily according to approval by the Program Advisory Committee. The number of proposals to the Photon Factory has been still growing. Three-hundred eighty two proposals were approved by the PAC in FY1994, which is an increase by thirteen percent compared to the previous year. Remarkable was growth in biology proposals, particularly proposals in protein crystallography. In FY 1994, we accepted approximately 20,000 man-days as general users, and almost ten percent of them were from abroad. We always open the facility to users, not only domestic but also international. Recently we have been concentrating our effort to upgrading of the light sources and reconstruction of the experimental stations to keep the Photon Factory an attractive research facility in the forthcoming years. We have already started a program of reducing the emittance of the 2.5-GeV storage ring, which now operates with an emittance of 110 nm-rad, to 27 nm-rad by modifying the lattice, with the goal of operation at the reduced emittance in the fall of 1997. We also have conceived of a conversion of the TRISTAN Accumulation Ring to a dedicated light source of high energies. The on-going TRISTAN project will terminate by the end of 1995, and the TRISTAN Main Ring will be converted to a new B-Factory. At this moment, the TRISTAN Accumulation Ring will be disused as the injector to the Main Ring, and conversion of the AR to a dedicated light source becomes possible. (J.P.N.)

  3. Photon Factory Activity Report, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    Photon Factory Activity Report no.12 deals with our activities in the period from October 1993 through September 1994. We operate two light sources at the Photon Factory; the 2.5-GeV Photon Factory storage ring, which is a dedicated light source, and the 6.5-GeV TRISTAN Accumulation Ring, which is parasitically used as a light source. We keep more than seventy experimental stations at two facilities, and accept experiments primarily according to approval by the Program Advisory Committee. The number of proposals to the Photon Factory has been still growing. Three-hundred eighty two proposals were approved by the PAC in FY1994, which is an increase by thirteen percent compared to the previous year. Remarkable was growth in biology proposals, particularly proposals in protein crystallography. In FY 1994, we accepted approximately 20,000 man-days as general users, and almost ten percent of them were from abroad. We always open the facility to users, not only domestic but also international. Recently we have been concentrating our effort to upgrading of the light sources and reconstruction of the experimental stations to keep the Photon Factory an attractive research facility in the forthcoming years. We have already started a program of reducing the emittance of the 2.5-GeV storage ring, which now operates with an emittance of 110 nm-rad, to 27 nm-rad by modifying the lattice, with the goal of operation at the reduced emittance in the fall of 1997. We also have conceived of a conversion of the TRISTAN Accumulation Ring to a dedicated light source of high energies. The on-going TRISTAN project will terminate by the end of 1995, and the TRISTAN Main Ring will be converted to a new B-Factory. At this moment, the TRISTAN Accumulation Ring will be disused as the injector to the Main Ring, and conversion of the AR to a dedicated light source becomes possible. (J.P.N.)

  4. Photon Factory Activity Report, 1994

    International Nuclear Information System (INIS)

    1995-01-01

    Photon Factory Activity Report no.12 deals with our activities in the period from October 1993 through September 1994. We operate two light sources at the Photon Factory; the 2.5-GeV Photon Factory storage ring, which is a dedicated light source, and the 6.5-GeV TRISTAN Accumulation Ring, which is parasitically used as a light source. We keep more than seventy experimental stations at two facilities, and accept experiments primarily according to approval by the Program Advisory Committee. The number of proposals to the Photon Factory has been still growing. Three-hundred eighty two proposals were approved by the PAC in FY1994, which is an increase by thirteen percent compared to the previous year. Remarkable was growth in biology proposals, particularly proposals in protein crystallography. In FY 1994, we accepted approximately 20,000 man-days as general users, and almost ten percent of them were from abroad. We always open the facility to users, not only domestic but also international. Recently we have been concentrating our effort to upgrading of the light sources and reconstruction of the experimental stations to keep the Photon Factory an attractive research facility in the forthcoming years. We have already started a program of reducing the emittance of the 2.5-GeV storage ring, which now operates with an emittance of 110 nm-rad, to 27 nm-rad by modifying the lattice, with the goal of operation at the reduced emittance in the fall of 1997. We also have conceived of a conversion of the TRISTAN Accumulation Ring to a dedicated light source of high energies. The on-going TRISTAN project will terminate by the end of 1995, and the TRISTAN Main Ring will be converted to a new B-Factory. At this moment, the TRISTAN Accumulation Ring will be disused as the injector to the Main Ring, and conversion of the AR to a dedicated light source becomes possible. (J.P.N.)

  5. Engineering Microbial Cells for the Biosynthesis of Natural Compounds of Pharmaceutical Significance

    Directory of Open Access Journals (Sweden)

    Philippe Jeandet

    2013-01-01

    Full Text Available Microbes constitute important platforms for the biosynthesis of numerous molecules of pharmaceutical interest such as antitumor, anticancer, antiviral, antihypertensive, antiparasitic, antioxidant, immunological agents, and antibiotics as well as hormones, belonging to various chemical families, for instance, terpenoids, alkaloids, polyphenols, polyketides, amines, and proteins. Engineering microbial factories offers rich opportunities for the production of natural products that are too complex for cost-effective chemical synthesis and whose extraction from their originating plants needs the use of many solvents. Recent progresses that have been made since the millennium beginning with metabolic engineering of microorganisms for the biosynthesis of natural products of pharmaceutical significance will be reviewed.

  6. Handbook factory planning and design

    CERN Document Server

    Wiendahl, Hans-Peter; Nyhuis, Peter

    2015-01-01

    This handbook introduces a methodical approach and pragmatic concept for the planning and design of changeable factories that act in strategic alliances to supply the ever-changing needs of the global market. In the first part, the change drivers of manufacturing enterprises and the resulting new challenges are considered in detail with focus on an appropriate change potential. The second part concerns the design of the production facilities and systems on the factory levels work place, section, building and site under functional, organisational, architectural and strategic aspects keeping in mind the environmental, health and safety aspects including corporate social responsibility. The third part is dedicated to the planning and design method that is based on a synergetic interaction of process and space. The accompanying project management of the planning and construction phase and the facility management for the effective utilization of the built premises close the book. -        Concise overview o...

  7. RIKEN RI Beam Factory project

    Energy Technology Data Exchange (ETDEWEB)

    Yano, Yasushige; Goto, Akira; Katayama, Takeshi [Institute of Physical and Chemical Research, Wako, Saitama (Japan)

    1997-03-01

    The RARF proposes `RIKEN RI Beam Factory` as a next facility-expanding project. The factory makes it the primary aim to provide RI (Radioactive Isotope) beams covering over the whole atomic-mass range with the world-highest intensity in a wide energy range up to several hundreds MeV/nucleon. These RI beams are generated by the fragmentation of high-intensity heavy-ion beams. For the efficient production heavy-ion energies will be boosted up to over 100 MeV/nucleon even for very heavy ions by a K2500-MeV superconducting ring cyclotron serving as a post accelerator of the existing K540-MeV ring cyclotron. A new type of experimental installation called `MUSES` (Multi-USe Experimental Storage rings) will be constructed as well. With MUSES, various types of unique colliding experiments will become possible. (author)

  8. On KEK B-Factory

    Science.gov (United States)

    Sugawara, H.

    2009-07-01

    There are two principles which the management of a research institute like KEK must respect when dealing with such big project as B-Factory. One is the scientific merit of the project and the other is the organizational consideration which includes financial, human, technical and historical elements. Ideally, the two principles are to be fully taken into account. But, in many cases, one or the other is only partially fulfilled due to unavoidable circumstances. The lack of flexibility to respond to all possible situations is more dangerous and may lead to a disaster as in the case of SSC. I will describe the process which lead to the successful construction, operation and physics presentations of KEK B-Factory following faithfully the official records.

  9. On KEK B-factory

    International Nuclear Information System (INIS)

    Sugawara, Hirotaka

    2009-01-01

    There are two principles which the management of a research institute like KEK must respect when dealing with such big project as B-Factory. One is the scientific merit of the project and the other is the organizational consideration which includes financial, human, technical and historical elements. Ideally, the two principles are to be fully taken into account. But, in many cases, one or the other is only partially fulfilled due to unavoidable circumstances. The lack of flexibility to respond to all possible situations is more dangerous and may lead to a disaster as in the case of SSC. I will describe the process which lead to the successful construction, operation and physics presentations of KEK B-Factory following faithfully the official records. (author)

  10. Apiary B Factory lattice design

    International Nuclear Information System (INIS)

    Donald, M.H.R.; Garren, A.A.

    1991-04-01

    The Apiary B Factory is a proposed high-intensity electron-positron collider. This paper will present the lattice design for this facility, which envisions two rings with unequal energies in the PEP tunnel. The design has many interesting optical and geometrical features due to the needs to conform to the existing tunnel, and to achieve the necessary emittances, damping times and vacuum. Existing hardware is used to a maximum extent. 8 figs. 1 tab

  11. A kaon factory for TRIUMF

    International Nuclear Information System (INIS)

    Measday, D.F.

    1988-11-01

    The design study for the TRIUMF Kaon Factory has recently been funded. A short discussion of the scientific motivation is given first, followed by a brief description of the 30 GeV synchrotron which is being proposed. There will be five rings altogether using the present TRIUMF 500 MeV cyclotron as an injector. If the project is funded in 1990 the accelerators would be completed in 1995 or so, and the experimental programme would start a year later

  12. Photon Factory activity report, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    The Photon Factory at the National Laboratory for High Energy Physics is a national facility for scientific research utilizing synchrotron radiation. Although the Photon Factory operator the linear injector, two light sources including the 2.5 GeV storage ring and the 6.5 GeV TRISTAN accumulation Ring as well as a major fraction of their beamlines and experimental station. This report is covered the period from October 1994 to September 1995. The total number of proposals by this PAC was 399 in 1995. Facility development projects currently in progress include the following, TRISTAN Super Light Facility (TSLF) project, VUV-FEL project, KEKB project and Slow-positron Source. This report contents outline of the Photon Factory, introduction, scientific disciplines, electronic properties of condensed matters, atomic and molecular science, X-ray imaging, radiobiology using synchrotron radiation, structural properties of condensed matters, structural properties of solid surfaces and adsorbates, structure and function of proteins, theoretical researches, experimental facilities, beamlines, new instrumentation, AR Upgrade, collaborations, projects, user`s short reports, list of published papers 1994/95. (S.Y.)

  13. Photon Factory activity report, 1995

    International Nuclear Information System (INIS)

    1996-01-01

    The Photon Factory at the National Laboratory for High Energy Physics is a national facility for scientific research utilizing synchrotron radiation. Although the Photon Factory operator the linear injector, two light sources including the 2.5 GeV storage ring and the 6.5 GeV TRISTAN accumulation Ring as well as a major fraction of their beamlines and experimental station. This report is covered the period from October 1994 to September 1995. The total number of proposals by this PAC was 399 in 1995. Facility development projects currently in progress include the following, TRISTAN Super Light Facility (TSLF) project, VUV-FEL project, KEKB project and Slow-positron Source. This report contents outline of the Photon Factory, introduction, scientific disciplines, electronic properties of condensed matters, atomic and molecular science, X-ray imaging, radiobiology using synchrotron radiation, structural properties of condensed matters, structural properties of solid surfaces and adsorbates, structure and function of proteins, theoretical researches, experimental facilities, beamlines, new instrumentation, AR Upgrade, collaborations, projects, user's short reports, list of published papers 1994/95. (S.Y.)

  14. Photon Factory activity report, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    The Photon Factory at the National Laboratory for High Energy Physics is a national facility for scientific research utilizing synchrotron radiation. Although the Photon Factory operator the linear injector, two light sources including the 2.5 GeV storage ring and the 6.5 GeV TRISTAN accumulation Ring as well as a major fraction of their beamlines and experimental station. This report is covered the period from October 1994 to September 1995. The total number of proposals by this PAC was 399 in 1995. Facility development projects currently in progress include the following, TRISTAN Super Light Facility (TSLF) project, VUV-FEL project, KEKB project and Slow-positron Source. This report contents outline of the Photon Factory, introduction, scientific disciplines, electronic properties of condensed matters, atomic and molecular science, X-ray imaging, radiobiology using synchrotron radiation, structural properties of condensed matters, structural properties of solid surfaces and adsorbates, structure and function of proteins, theoretical researches, experimental facilities, beamlines, new instrumentation, AR Upgrade, collaborations, projects, user`s short reports, list of published papers 1994/95. (S.Y.)

  15. Photon Factory activity report, 1990

    International Nuclear Information System (INIS)

    1991-01-01

    The Photon Factory has grown at a considerable rate, and 600 experiments are carried out in 1991, while the number of users is now 2300 including about 500 from industrial sectors. The use of synchrotron radiation increased from fundamental research to industrial development. The development at the Photon Factory is supported by the capability of the accelerators. At present, the 2.5 GeV PF ring is operated with positrons at the initial beam current of 350 mA. The total operation time was 3500 hours in the fiscal year 1990. The development of an avalanche mode photodiode, the observation of quantum beat in the experiment of nuclear Bragg scattering, the measurement of photo-electron and photo-ion spectroscopy were carried out. The conversion of TRISTAN main ring to an ultrahigh brilliance and high coherence source is planned for the future. The annual PF Symposium was held, and Professor H. Winick gave the lecture 'Ultrahigh brightness and coherent radiation from large storage rings'. In this report, the outline of the Photon Factory and the activities in Divisions of Injector Linac, Light Source and Instrumentation are described. (K.I.)

  16. Multi products single machine economic production quantity model with multiple batch size

    Directory of Open Access Journals (Sweden)

    Ata Allah Taleizadeh

    2011-04-01

    Full Text Available In this paper, a multi products single machine economic order quantity model with discrete delivery is developed. A unique cycle length is considered for all produced items with an assumption that all products are manufactured on a single machine with a limited capacity. The proposed model considers different items such as production, setup, holding, and transportation costs. The resulted model is formulated as a mixed integer nonlinear programming model. Harmony search algorithm, extended cutting plane and particle swarm optimization methods are used to solve the proposed model. Two numerical examples are used to analyze and to evaluate the performance of the proposed model.

  17. Exponential Smoothing for Multi-Product Lot-Sizing With Heijunka and Varying Demand

    Directory of Open Access Journals (Sweden)

    Grimaud Frédéric

    2014-06-01

    Full Text Available Here we discuss a multi-product lot-sizing problem for a job shop controlled with a heijunka box. Demand is considered as a random variable with constant variation which must be absorbed somehow by the manufacturing system, either by increased inventory or by flexibility in the production. When a heijunka concept (production leveling is used, fluctuations in customer orders are not transferred directly to the manufacturing system allowing for a smoother production and better production capacity utilization. The problem rather is to determine a tradeoff between the variability in the production line capacity requirement and the inventory level.

  18. 46_ _267 - 278__Aminu- Biosynthesis

    African Journals Online (AJOL)

    User

    ISSN 2006 – 6996. BIOSYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDY OF .... the excitation of surface Plasmon vibration with. AgNPs. ... Thin films of the sample were prepared on a carbon ... The resulting film on the SEM.

  19. Information Flow Scheduling in Concurrent Multi-Product Development Based on DSM

    Science.gov (United States)

    Sun, Qing-Chao; Huang, Wei-Qiang; Jiang, Ying-Jie; Sun, Wei

    2017-09-01

    Multi-product collaborative development is adopted widely in manufacturing enterprise, while the present multi-project planning models don't take technical/data interactions of multiple products into account. To decrease the influence of technical/data interactions on project progresses, the information flow scheduling models based on the extended DSM is presented. Firstly, information dependencies are divided into four types: series, parallel, coupling and similar. Secondly, different types of dependencies are expressed as DSM units, and the extended DSM model is brought forward, described as a block matrix. Furthermore, the information flow scheduling methods is proposed, which involves four types of operations, where partitioning and clustering algorithm are modified from DSM for ensuring progress of high-priority project, merging and converting is the specific computation of the extended DSM. Finally, the information flow scheduling of two machine tools development is analyzed with example, and different project priorities correspond to different task sequences and total coordination cost. The proposed methodology provides a detailed instruction for information flow scheduling in multi-product development, with specially concerning technical/data interactions.

  20. Serine biosynthesis and transport defects.

    Science.gov (United States)

    El-Hattab, Ayman W

    2016-07-01

    l-serine is a non-essential amino acid that is biosynthesized via the enzymes phosphoglycerate dehydrogenase (PGDH), phosphoserine aminotransferase (PSAT), and phosphoserine phosphatase (PSP). Besides its role in protein synthesis, l-serine is a potent neurotrophic factor and a precursor of a number of essential compounds including phosphatidylserine, sphingomyelin, glycine, and d-serine. Serine biosynthesis defects result from impairments of PGDH, PSAT, or PSP leading to systemic serine deficiency. Serine biosynthesis defects present in a broad phenotypic spectrum that includes, at the severe end, Neu-Laxova syndrome, a lethal multiple congenital anomaly disease, intermediately, infantile serine biosynthesis defects with severe neurological manifestations and growth deficiency, and at the mild end, the childhood disease with intellectual disability. A serine transport defect resulting from deficiency of the ASCT1, the main transporter for serine in the central nervous system, has been recently described in children with neurological manifestations that overlap with those observed in serine biosynthesis defects. l-serine therapy may be beneficial in preventing or ameliorating symptoms in serine biosynthesis and transport defects, if started before neurological damage occurs. Herein, we review serine metabolism and transport, the clinical, biochemical, and molecular aspects of serine biosynthesis and transport defects, the mechanisms of these diseases, and the potential role of serine therapy. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Information security of Smart Factories

    Science.gov (United States)

    Iureva, R. A.; Andreev, Y. S.; Iuvshin, A. M.; Timko, A. S.

    2018-05-01

    In several years, technologies and systems based on the Internet of things (IoT) will be widely used in all smart factories. When processing a huge array of unstructured data, their filtration and adequate interpretation are a priority for enterprises. In this context, the correct representation of information in a user-friendly form acquires special importance, for which the market today presents advanced analytical platforms designed to collect, store and analyze data on technological processes and events in real time. The main idea of the paper is the statement of the information security problem in IoT and integrity of processed information.

  2. Muon Colliders and Neutrino Factories

    Energy Technology Data Exchange (ETDEWEB)

    Kaplan, Daniel M. [IIT, Chicago

    2015-05-29

    Muon colliders and neutrino factories are attractive options for future facilities aimed at achieving the highest lepton-antilepton collision energies and precision measurements of Higgs boson and neutrino mixing matrix parameters. The facility performance and cost depend on how well a beam of muons can be cooled. Recent progress in muon cooling design studies and prototype tests nourishes the hope that such facilities could be built starting in the coming decade. The status of the key technologies and their various demonstration experiments is summarized. Prospects "post-P5" are also discussed.

  3. Magnets for TRIUMF's KAON factory

    International Nuclear Information System (INIS)

    Otter, A.J.; Reeve, P.A.

    1991-05-01

    The KAON Factory will require over 2000 magnets to transport protons from the existing 500 Mev cyclotron through three storage rings and two synchrotrons and deliver them to the experimental area at 30 Gev. The magnet requirements are summarized and the results of measurements on prototypes for the 50 hz Booster magnets are compared with design values. This paper will address three topics: the results of prototype work, some of the more difficult design aspects of other magnets and the tolerances required to achieve production magnets uniform to ± 2 parts in 10 4 . (Author) 10 refs., 3 figs., tab

  4. Biosynthesis of oleamide.

    Science.gov (United States)

    Mueller, Gregory P; Driscoll, William J

    2009-01-01

    Oleamide (cis-9-octadecenamide) is the prototype long chain primary fatty acid amide lipid messenger. The natural occurrence of oleamide was first reported in human serum in 1989. Subsequently oleamide was shown to accumulate in the cerebrospinal fluid of sleep-deprived cats and to induce sleep when administered to experimental animals. Accordingly, oleamide first became known for its potential role in the mechanisms that mediate the drive to sleep. Oleamide also has profound effects on thermoregulation and acts as an analgesic in several models of experimental pain. Although these important pharmacologic effects are well establish, the biochemical mechanism for the synthesis of oleamide has not yet been defined. This chapter reviews the biosynthetic pathways that have been proposed and highlights two mechanisms which are most supported by experimental evidence: the generation of oleamide from oleoylglycine by the neuropeptide processing enzyme, peptidylglycine alpha-amidating monooxygenase (PAM), and alternatively, the direct amidation of oleic acid via oleoyl coenzyme A by cytochrome c using ammonia as the nitrogen source. The latter mechanism is discussed in the context of apoptosis where oleamide may play a role in regulating gap junction communication. Lastly, several considerations and caveats pertinent to the future study oleamide biosynthesis are discussed.

  5. Glycolipid biosynthesis in cyanobacteria

    International Nuclear Information System (INIS)

    Van Dusen, W.J.; Jaworski, J.G.

    1987-01-01

    The biosynthesis of monogalactosyldiacyl-glycerol (MGDG) was studied in five different cyanobacteria. Previous work has shown Anabaena variabilis to synthesize both MGDG and monoglucosyl-diacylglycerol (MG1cDG) with MG1cDG being the precursor of MGDG. They have examined four other cyanobacteria to determine if a similar relationship exists. The cyanobacteria studied were Anabaena variabilis, Chlorogloeopsis sp., Schizothrix calcicola, Anacystis nidulans, and Anacystis marina. Each were grown in liquid culture and lipids were labeled with 14 C]CO 2 for 20 min., 1.0 hr, 1.0 hr + 10 hr chase. Glycolipids were analyzed by initial separation of MGDG and MG1cDG by TLC followed by further analysis by HPLC. Complete separation of molecular species was obtained isocratically on an ODS column. All of the cyanobacteria labeled 16-C and 18-C fatty acids except for A. marina which labeled only 14-C and 16-C fatty acids. Desaturation of the fatty acids could be observed in the 1.0 hr and chase experiments. All were capable of labeling both MG1cDG and MGDG with the precursor-product relationship being observed. There does not appear to be a direct relationship between the epimerization of the sugar moiety and fatty acid desaturation

  6. Photon Factory activity report, 1988

    International Nuclear Information System (INIS)

    1989-01-01

    Since the foundation of Photon Factory a decade age, it has played an important role as a unique synchrotron X-ray radiation source in Japan. Installation of various insertion devices, storage of intense positron beam and reduction of beam emittance were the substantial achievements in the last several years. The exploitation of the TRISTAN Accumulation Ring as a synchrotron radiation source has paved the way for a new potential of development. All these activities have brought about the increase of beamlines and the expansion of scientific fronts. Third International Conference on Synchrotron Radiation Instrumentation held in Tsukuba was one of the most highlighted events for the facility. In coming years, it is intended to open new research fields using the promising single bunch beam and circularly polarized wiggler radiation. The TRISTAN Main Ring also will be applied to synchrotron radiation research. The Photon Factory in a national synchrotron radiation research facility affiliated to the National Laboratory for High Energy Physics, and it consists of a 2.5 GeV electron linac, a 2.5 GeV storage ring as a synchrotron light source, beam lines and experimental stations. The operation, improvement and development in respective departments are reported. (Kako, I.)

  7. Information Management for Factory Planning and Design

    OpenAIRE

    Chen, Danfang

    2012-01-01

    This thesis is dedicated to the manufacturing industry for the improvement of information management within the factory planningand design domain, and for more efficient factory planning and design. Currently the manufacturing industry lacks sufficient methods for capturing, structuring, and representing information and knowledge for easy access, exchange, integration and reuse within the domain. Therefore the focus of this thesis is on information and knowledge management within factory plan...

  8. WQO is Decidable for Factorial Languages

    KAUST Repository

    Atminas, Aistis

    2017-08-08

    A language is factorial if it is closed under taking factors, i.e. contiguous subwords. Every factorial language can be described by an antidictionary, i.e. a minimal set of forbidden factors. We show that the problem of deciding whether a factorial language given by a finite antidictionary is well-quasi-ordered under the factor containment relation can be solved in polynomial time. We also discuss possible ways to extend our solution to permutations and graphs.

  9. Exploring the fungal protein cadre in the biosynthesis of PbSe quantum dots

    Energy Technology Data Exchange (ETDEWEB)

    Jacob, Jaya Mary; Sharma, Sumit; Balakrishnan, Raj Mohan, E-mail: rajmohanbala@gmail.com

    2017-02-15

    Highlights: • Pb and Se stress activates specific metal detoxification surge in the fungus. • Fungus releases phytochelatins, metallothioneins, super oxide dismutases etc. • These mechanisms capacitate the fungi as bio-factories for synthesis of PbSe QDs. • A pathway for PbSe QD biosynthesis by marine Aspergillus terreus was elucidated - Abstract: While a large number of microbial sources have recently emerged as potent sources for biosynthesis of chalcogenide quantum dots (QDs), studies regarding their biomimetic strategies that initiate QD biosynthesis are scarce. The present study describes several mechanistic aspects of PbSe QD biosynthesis using marine Aspergillus terreus. Scanning electron microscopic (SEM) studies indicated distinctive morphological features such as abrasion and agglomeration on the fungal biomass after the biosynthesis reaction. Further, the biomass subsequent to the heavy metal/metalloid precursor was characterized with spectral signatures typical to primary and secondary stress factors such as thiol compounds and oxalic acid using Fourier Transform Infra-Red Spectroscopic (FTIR) analysis. An increase in the total protein content in the reaction mixture after biosynthesis was another noteworthy observation. Further, metal-phytochelatins were identified as the prominent metal-ion trafficking components in the reaction mixture using Liquid Chromatography Mass Spectroscopic analysis (LCMS). Subsequent assays confirmed the involvement of metal binding peptides namely metallothioneins and other anti-oxidant enzymes that might have played a prominent role in the microbial metal detoxification system for the biosynthesis of PbSe QDs. Based on these findings a possible mechanism for the biosynthesis of PbSe QDs by marine A. terreus has been elucidated.

  10. Preserving the Modernist Vertical Urban Factory

    Directory of Open Access Journals (Sweden)

    Nina Rappaport

    2016-07-01

    Full Text Available This essay is adapted in part, from the section, “Modern Factory Architecture” case studies from Nina Rappaport’s book Vertical Urban Factory, published by Actar this spring. Vertical Urban Factory began as an architecture studio, and then an exhibition, which opened in New York in 2011 and traveled to Detroit and Toronto in 2012. Last year the show was displayed at Archizoom at EPFL in Lausanne; Industry City, Brooklyn; and the Charles Moore School of Architecture at Kean University, in New Jersey. The project continues as a think tank evaluating factory futures and urban industrial potential.

  11. Regulation of cell wall biosynthesis.

    Science.gov (United States)

    Zhong, Ruiqin; Ye, Zheng-Hua

    2007-12-01

    Plant cell walls differ in their amount and composition among various cell types and even in different microdomains of the wall of a given cell. Plants must have evolved regulatory mechanisms controlling biosynthesis, targeted secretion, and assembly of wall components to achieve the heterogeneity in cell walls. A number of factors, including hormones, the cytoskeleton, glycosylphosphatidylinositol-anchored proteins, phosphoinositides, and sugar nucleotide supply, have been implicated in the regulation of cell wall biosynthesis or deposition. In the past two years, there have been important discoveries in transcriptional regulation of secondary wall biosynthesis. Several transcription factors in the NAC and MYB families have been shown to be the key switches for activation of secondary wall biosynthesis. These studies suggest a transcriptional network comprised of a hierarchy of transcription factors is involved in regulating secondary wall biosynthesis. Further investigation and integration of the regulatory players participating in the making of cell walls will certainly lead to our understanding of how wall amounts and composition are controlled in a given cell type. This may eventually allow custom design of plant cell walls on the basis of our needs.

  12. Photon Factory activity report, 1987

    International Nuclear Information System (INIS)

    1987-01-01

    The Photon Factory made great strides in 1987. The low emittance operation of the PF ring was achieved in March, and resulted favorably in the increase of brilliance from 2 to 20 times for all the beam lines with high beam stability. At the same time, the installation of inserted devices was under way for all available straight sections of the ring. A 54-pole wiggler-undulator has been commissioned at BL-16. The devices to be inserted in the near future are a multipole wiggler for BL-13, an undulator for BL-19, and an undulator for circular polarized radiation at BL-28. The construction of beam lines continued, and four new beam lines, BL-6, BL-9, BL-16 and BL-17, are now in operation, BL-13 and BL-19 are under construction, and BL-3, BL-5, BL-18, BL-20 and BL-28 are in the design stage. Since its inauguration with four beam lines in 1982, the Photon Factory has grown rapidly, and approaches the goal of operating the PF ring with positrons in full use of its 24 beam ports and the straight sections for inserted devices. The total operation time was limited to 3,000 hours by the budget for fiscal year 1987, and about 80 % of the operation hours were devoted to the experiments of users. The nearly perfect operation of the 400 m long linac has continued in 1987, and has supplied both electrons and positrons to the TRISTAN collision experiment. The light source of a 2.5 GeV electron storage ring was normally operated. (Kako, I.)

  13. A Tau-Charm Factory at CEBAF

    Energy Technology Data Exchange (ETDEWEB)

    Seth, K.K. [Northwestern Univ., Evanston, IL (United States)

    1994-04-01

    It is proposed that a Tau Charm Factory represents a natural extension of CEBAF into higher energy domains. The exciting nature of the physics of charm quarks and tau leptons is briefly reviewed and it is suggested that the concept of a linac-ring collider as a Tau Charm Factory at CEBAF should be seriously studied.

  14. Biosynthesis of silver nanoparticles synthesized by Aspergillus ...

    Indian Academy of Sciences (India)

    Biotechnology Division, Applied Science Department, University of ... Abstract. In the present study, biosynthesis of silver nanoparticles and its antioxidant, antimicrobial and cytotoxic ... example of the biosynthesis using fungi was that the cell-.

  15. Photon Factory activity report, 1989

    International Nuclear Information System (INIS)

    1990-01-01

    At the Photon Factory about 500 experiments are now running annually with about 50 experimental stations, the total operation time of the 2.5 GeV storage ring was 3400 hour in 1989, and the number of users was more than 2000, including 300 scientists from industry. This wide usage of synchrotron radiation has been supported by good performance of the accelerators. The positron beam current of the linac was increased for rapid injection (injection time: 20 min). The entire roof of the Light Source building was covered with thermal insulator (urethane-foam). This has greatly improved the beam stability of the ring. It has been operated at an initial ring current of 350 mA with a life time of 20 hours. Distinctive instrumentation at the Photon Factory has expanded to various fields such as angle-resolved ion-spectroscopy, dispersive EXAFS, trace impurity X-ray fluorescence analysis, plane-wave topography, structure analysis under high pressure, and imaging plates. Recently, experiments of protein structure analysis have been carried out extensively; Sakabe developed a new type of Weissenberg camera for protein crystallography, and about 50 experiments have been done for the past six months by a combination of Sakabe camera and imaging plates. The 2.5 GeV light source is now at an entrance of its harvest season. The TRISTAN Accumulation Ring has been used throughout this year in a time sharing basis with the TRISTAN experiment; twenty minutes for injection to TRISTAN Main Ring and 2 hours for SR experiment. The main subject has been magnetic Compton scattering with circularly polarized wiggler radiation. Such experiences enable us to expand our perspective for research in the following decade; we are investigating the possibility of operating the TRISTAN Main Ring at 6-8 GeV with 6000-pole undulaters, resulting in an extremely brilliant radiation source (Emittance: 0.1 nm·rad at 5 GeV with damping rings). (J.P.N.)

  16. The KAON Factory at TRIUMF

    International Nuclear Information System (INIS)

    Craddock, M.K.

    1992-08-01

    The TRIUMF KAON Factory is designed to produce beams of kaons, antiprotons, other hadrons and neutrinos 100 times more intense, or cleaner, than are available now, for a broad range of particle and nuclear physics experiments. This will require a 100 μA beam of 30 GeV protons, to be produced by an interleaved sequence of two fast-cycling synchrotrons and three storage rings, with the existing TRIUMF H - cyclotron as injector. An $11-million preconstruction study has enabled the overall design to be reviewed and prototypes of various components to be built and evaluated -fast-cycling dipole and quadrupole magnets, a dual-frequency magnet power supply, ceramic beam pipes with internal rf shields, and rf cavity (using perpendicular bias), an extraction kicker, and rf beam chopper, and production targets. Environmental, industrial and economic impact studies have also been completed and the cost estimates and schedule updated. The total cost of $708 million (Canadian) will be shared equally between Canada, British Columbia and international contributors: the first two-thirds of this sum have already been approved and negotiations for the remainder are under way. 25 refs., 7 figs

  17. The KAON factory at TRIUMF

    International Nuclear Information System (INIS)

    Craddock, M.K.

    1992-07-01

    The TRIUMF KAON Factory is designed to produce beams of kaons, antiprotons, other hadrons and neutrinos 100 times more intense, or cleaner, than are available now, for a broad range of particle and nuclear physics experiments. This will require a 100 μA beam of 30 GeV protons, to be produced by an interleaved sequence of two fast-cycling synchrotrons and three storage rings, with the existing TRIUMF H - cyclotron as injector. An $11-million pre-construction study has enabled the overall design to be reviewed and prototypes of various components to be built and evaluated: fast-cycling dipole and quadrupole magnets, a dual frequency magnet power supply, ceramic beam pipes with internal rf shields, an rf cavity (using perpendicular bias), an extraction kicker, an rf beam chopper, and production targets. Environmental, industrial and economic impact studies have also been completed and the cost estimates and schedule updated. The total cost of $708 million (Canadian) will be shared equally between Canada, British Columbia and international contributors; the first two-thirds of this sum have already been approved and negotiations for the remainder are under way. 26 refs., 6 figs

  18. Factorial structure of aerobics athletes’ fitness

    Directory of Open Access Journals (Sweden)

    T.V. Shepelenko

    2017-11-01

    Full Text Available The purpose of the research is to develop an algorithm of teams’ formation in sport aerobics and to define factorial structure of athletes’ fitness. Material : in the research sport aerobics’ athletes (n=19 participated. All athletes are members of Kharkiv national team (Ukraine. All athletes underwent complete medical examination. The functional condition of an organism (arterial blood pressure, indicators of a variability of the rhythm of the heart, treadbahn testing, psycho-physiological state (time’s determination of simple and complex reaction were defined. The physical development and physical fitness and stability of vestibular system were also defined. The factorial and cluster analysis were used. Results : The algorithm of teams’ formation in sport aerobics is developed for performances in various competitive categories. The algorithm contains all stages of standard procedure of the factorial and cluster analysis. In the factorial analysis the individual factorial values were also defined. Conclusions : The obtained data are recommended to be used at teams’ formation for performances in various competitive categories: team formation for pair and group performances. The general and individual factorial structure of athletes’ complex fitness is defined. It is possible to select athletes with similar qualities and with different qualities for the mixed performances. The determination of individual factorial structure of fitness permits to estimate objectively variants of athletes’ formation in groups.

  19. SatisFactory Final System Evaluation Report

    OpenAIRE

    Sunlight SA

    2018-01-01

    The present document is a deliverable of the SatisFactory project, funded by the European Commission’s Directorate-General for Research and Innovation (DG RTD), under its Horizon 2020 Research and innovation programme (H2020). The main objective of this deliverable is to report on the SatisFactory Final System Evaluation, with regards to the industrial pilots at COMAU and SUNLIGHT. The evaluation of SatisFactory platform is based on the implementation of the business scenarios where each tool...

  20. STANFORD (SLAC): B factory construction begins

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1994-03-15

    At a ceremony marking the start of construction, members of the US Congress and Secretary of Energy Hazel O'Leary hailed the new Asymmetric B Factory as the key to continued vitality of the Stanford Linear Accelerator Center (SLAC). Being built in collaboration with the Lawrence Berkeley Laboratory and the Lawrence Livermore National Laboratory, the B factory is a $177 million upgrade of the existing PEP electron-positron collider. Scheduled for completion in 1998, the B factory will generate many millions of B mesons, allowing, among other physics, an intensive search for the phenomena of CP violation in the decays of these particles.

  1. STANFORD (SLAC): B factory construction begins

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    At a ceremony marking the start of construction, members of the US Congress and Secretary of Energy Hazel O'Leary hailed the new Asymmetric B Factory as the key to continued vitality of the Stanford Linear Accelerator Center (SLAC). Being built in collaboration with the Lawrence Berkeley Laboratory and the Lawrence Livermore National Laboratory, the B factory is a $177 million upgrade of the existing PEP electron-positron collider. Scheduled for completion in 1998, the B factory will generate many millions of B mesons, allowing, among other physics, an intensive search for the phenomena of CP violation in the decays of these particles

  2. Factorial correlators: angular scaling within QCD jets

    International Nuclear Information System (INIS)

    Peschanski, R.

    2001-01-01

    Factorial correlators measure the amount of dynamical correlation in the multiplicity between two separated phase-space windows. We present the analytical derivation of factorial correlators for a QCD jet described at the double logarithmic (DL) accuracy. We obtain a new angular scaling property for properly normalized correlators between two solid-angle cells or two rings around the jet axis. Normalized QCD factorial correlators scale with the angular distance and are independent of the window size. Scaling violations are expected beyond the DL approximation, in particular from the subject structure. Experimental tests are feasible, and thus would be welcome. (orig.)

  3. Deficits and Solutions in the Development of Modular Factory Systems

    OpenAIRE

    Achim Kampker; Peter Burggräf; Moritz Krunke; Hanno Voet

    2017-01-01

    As a reaction to current challenges in factory planning, many companies think about introducing factory standards to lower planning times and decrease planning costs. If these factory standards are set-up with a high level of modularity, they are defined as modular factory systems. This paper deals with the main current problems in the application of modular factory systems in practice and presents a solution approach with its basic models. The methodology is based on methods from factory pla...

  4. Analysis of a yearly multi-round, multi-period, multi-product transmission rights auction

    International Nuclear Information System (INIS)

    Ziogos, N.P.; Bakirtzis, A.G.

    2008-01-01

    A yearly multi-round, multi-period, multi-product transmission rights (TR) auction issuing both point-to-point Financial Transmission Rights (FTRs) and Flow-Gate Rights (FGRs) is studied in this paper. In each round the TR market participants (buyers or sellers) submit their bid or offer prices based on past energy market performance. A Locational Marginal Pricing (LMP) based energy market is assumed. The TR market participants' bid or offer prices reflect their expectation of the average annual LMP differences between withdrawal and injections points for FTRs and of the transmission link capacity prices for FGRs. The TR auction is performed in four rounds; in each round 25% of the entire system capability is awarded. TRs that are awarded in one round are modeled as fixed injections in subsequent rounds. Market participants that have acquired TRs in one round can sell them in subsequent rounds. A market participant can submit bids or offers for on-peak, off-peak or 24-h TRs. A three-area, nine-bus test system with six TR market participants is used for the analysis of the TR auction. (author)

  5. Optimization of a Multi-Product Intra-Supply Chain System with Failure in Rework.

    Science.gov (United States)

    Chiu, Singa Wang; Chen, Shin-Wei; Chang, Chih-Kai; Chiu, Yuan-Shyi Peter

    2016-01-01

    Globalization has created tremendous opportunities, but also made business environment highly competitive and turbulent. To gain competitive advantage, management of present-day transnational firms always seeks options to trim down various transaction and coordination costs, especially in the area of controllable intra-supply chain system. This study investigates a multi-product intra-supply chain system with failure in rework. To achieve maximum machine utilization, multiple products are fabricated in succession on a single machine. During the process, production of some defective items is inevitable. Reworking of nonconforming items is used to reduce the quality cost in production and achieving the goal of lower overall production cost. Because reworks are sometimes unsuccessful, failures in rework are also considered in this study. Finished goods for each product are transported to the sales offices when the entire production lot is quality assured after rework. A multi-delivery policy is used, wherein fixed quantity n installments of the finished lot are transported at fixed intervals during delivery time. The objective is to jointly determine the common production cycle time and the number of deliveries needed to minimize the long-term expected production-inventory-delivery costs for the problem. With the help of a mathematical model along with optimization technique, the optimal production-shipment policy is obtained. We have used a numerical example to demonstrate applicability of the result of our research.

  6. Guidelines for Risk-Based Changeover of Biopharma Multi-Product Facilities.

    Science.gov (United States)

    Lynch, Rob; Barabani, David; Bellorado, Kathy; Canisius, Peter; Heathcote, Doug; Johnson, Alan; Wyman, Ned; Parry, Derek Willison

    2018-01-01

    In multi-product biopharma facilities, the protection from product contamination due to the manufacture of multiple products simultaneously is paramount to assure product quality. To that end, the use of traditional changeover methods (elastomer change-out, full sampling, etc.) have been widely used within the industry and have been accepted by regulatory agencies. However, with the endorsement of Quality Risk Management (1), the use of risk-based approaches may be applied to assess and continuously improve established changeover processes. All processes, including changeover, can be improved with investment (money/resources), parallel activities, equipment design improvements, and standardization. However, processes can also be improved by eliminating waste. For product changeover, waste is any activity not needed for the new process or that does not provide added assurance of the quality of the subsequent product. The application of a risk-based approach to changeover aligns with the principles of Quality Risk Management. Through the use of risk assessments, the appropriate changeover controls can be identified and controlled to assure product quality is maintained. Likewise, the use of risk assessments and risk-based approaches may be used to improve operational efficiency, reduce waste, and permit concurrent manufacturing of products. © PDA, Inc. 2018.

  7. The factory as a battlefield

    Directory of Open Access Journals (Sweden)

    Helena Chávez Mac Gregor

    Full Text Available The crisis of labour is also one of representation. Some contemporary artists working with moving images have been questioning how to represent capital, labour and the worker. Isaac Julien or Harun Farocki, for example, have focused on interlacing characters - from fiction or reality - with geopolitical spaces in order to present the entanglement of the economical new order with the new forms of labour. The South African artist Simon Gush has shifted from this trend in order to present labour without directly representing the workers. In his artwork there is no longer a search for the political subject as a historical force or for the individuals who occupied its place; instead he leads viewers to a critical reading of an object, allowing a staging of the past from the viewpoint of the present. That is what I think Red does. In this article I explore Gush's connections with Marx, Benjamin and Steyerl to show how Gush's work is part of a critical tradition that has abandoned the subject as the privileged instance of political agency; turning the emphasis of the modern schema upside down, it focuses on the object as the force of emancipation. I would like to suggest that Gush used an object, Mandela's red Mercedes-Benz, to produce another image so that the story told is not necessarily that of a symbol of pacification, but one in which the factory was a battlefield. In this way I explore the emancipatory potencies of the object. What I propose is a reading of Red from the point of view of a return to the thing, where the latter becomes a political force.

  8. Rational synthetic pathway refactoring of natural products biosynthesis in actinobacteria.

    Science.gov (United States)

    Tan, Gao-Yi; Liu, Tiangang

    2017-01-01

    Natural products (NPs) and their derivatives are widely used as frontline treatments for many diseases. Actinobacteria spp. are used to produce most of NP antibiotics and have also been intensively investigated for NP production, derivatization, and discovery. However, due to the complicated transcriptional and metabolic regulation of NP biosynthesis in Actinobacteria, especially in the cases of genome mining and heterologous expression, it is often difficult to rationally and systematically engineer synthetic pathways to maximize biosynthetic efficiency. With the emergence of new tools and methods in metabolic engineering, the synthetic pathways of many chemicals, such as fatty acids and biofuels, in model organisms (e.g. Escherichia coli ), have been refactored to realize precise and flexible control of production. These studies also offer a promising approach for synthetic pathway refactoring in Actinobacteria. In this review, the great potential of Actinobacteria as a microbial cell factory for biosynthesis of NPs is discussed. To this end, recent progress in metabolic engineering of NP synthetic pathways in Actinobacteria are summarized and strategies and perspectives to rationally and systematically refactor synthetic pathways in Actinobacteria are highlighted. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  9. Physics opportunities for a B Factory

    International Nuclear Information System (INIS)

    Quinn, H.R.

    1992-02-01

    In the short time allotted for this talk it is not possible to review all the physics opportunities offered by a B Factory. I focus on the physics of CP Violation and the resulting tests of the Standard Model

  10. Benthic carbonate factories of the Phanerozoic

    NARCIS (Netherlands)

    Schlager, W.

    2003-01-01

    Marine carbonate precipitation occurs in three basic modes: abiotic (or quasi-abiotic), biotically induced, and biotically controlled. On a geologic scale, these precipitation modes combine to form three carbonate production systems, or "factories" in the benthic environment: (1) tropical

  11. The physics of the B factories

    CERN Document Server

    Bevan, A J; Mannel, Th; Prell, S; Yabsley, B D; Abe, K; Aihara, H; Anulli, F; Arnaud, N; Aushev, T; Beneke, M; Beringer, J; Bianchi, F; Bigi, I I; Bona, M; Brambilla, N; Brodzicka, J; Chang, P; Charles, M J; Cheng, C H; Cheng, H -Y; Chistov, R; Colangelo, P; Coleman, J P; Drutskoy, A; Druzhinin, V P; Eidelman, S; Eigen, G; Eisner, A M; Faccini, R; Flood, K T; Gambino, P; Gaz, A; Gradl, W; Hayashii, H; Higuchi, T; Hulsbergen, W D; Hurth, T; Iijima, T; Itoh, R; Jackson, P D; Kass, R; Kolomensky, Yu G; Kou, E; Križan, P; Kronfeld, A; Kumano, S; Kwon, Y J; Latham, T E; Leith, D W G S; Lüth, V; Martinez-Vidal, F; Meadows, B T; Mussa, R; Nakao, M; Nishida, S; Ocariz, J; Olsen, S L; Pakhlov, P; Pakhlova, G; Palano, A; Pich, A; Playfer, S; Poluektov, A; Porter, F C; Robertson, S H; Roney, J M; Roodman, A; Sakai, Y; Schwanda, C; Schwartz, A J; Seidl, R; Sekula, S J; Steinhauser, M; Sumisawa, K; Swanson, E S; Tackmann, F; Trabelsi, K; Uehara, S; Uno, S; van der Water, R; Vasseur, G; Verkerke, W; Waldi, R; Wang, M Z; Wilson, F F; Zupan, J; Zupanc, A; Adachi, I; Albert, J; Banerjee, Sw; Ben-Haim, E; Biassoni, P; Cahn, R N; Cartaro, C; Chauveau, J; Chen, C; Chiang, C C; Cowan, R; Dalseno, J; Davier, M; Davies, C; Dingfelder, J C; Echenard, B; Epifanov, D; Fulsom, B G; Gabareen, A M; Gary, J W; Godang, R; Graham, M T; Hafner, A; Hamilton, B; Hartmann, T; Hayasaka, K; Hearty, C; Iwasaki, Y; Khodjamirian, A; Kusaka, A; Kuzmin, A; Lafferty, G D; Lazzaro, A; Li, J; Lindemann, D; Long, O; Lusiani, A; Marchiori, G; Martinelli, M; Miyabayashi, K; Mizuk, R; Mohanty, G B; Muller, D R; Nakazawa, H; Ongmongkolkul, P; Pacetti, S; Palombo, F; Pedlar, T K; Piilonen, L E; Pilloni, A; Poireau, V; Prothmann, K; Pulliam, T; Rama, M; Ratcliff, B N; Roudeau, P; Schrenk, S; Schroeder, T; Schubert, K R; Shen, C P; Shwartz, B; Soffer, A; Solodov, E P; Somov, A; Starič, M; Stracka, S; Telnov, A V; Todyshev, K Yu; Tsuboyama, T; Uglov, T; Vinokurova, A; Walsh, J J; Watanabe, Y; Won, E; Wormser, G; Wright, D H; Ye, S; Zhang, C C; Abachi, S; Abashian, A; Abe, N; Abe, R; Abe, T; Abrams, G S; Adam, I; Adamczyk, K; Adametz, A; Adye, T; Agarwal, A; Ahmed, H; Ahmed, M; Ahmed, S; Ahn, B S; Ahn, H S; Aitchison, I J R; Akai, K; Akar, S; Akatsu, M; Akemoto, M; Akhmetshin, R; Akre, R; Alam, M S; Albert, J N; Aleksan, R; Alexander, J P; Alimonti, G; Allen, M T; Allison, J; Allmendinger, T; Alsmiller, J R G; Altenburg, D; Alwyn, K E; An, Q; Anderson, J; Andreassen, R; Andreotti, D; Andreotti, M; Andress, J C; Angelini, C; Anipko, D; Anjomshoaa, A; Anthony, P L; Antillon, E A; Antonioli, E; Aoki, K; Arguin, J F; A, K; Arisaka, K; Asai, K; Asai, M; Asano, Y; Asgeirsson, D J; Asner, D M; Aso, T; Aspinwall, M L; Aston, D; Atmacan, H; Aubert, B; Aulchenko, V; Ayad, R; Azemoon, T; Aziz, T; Azzolini, V; Azzopardi, D E; Baak, M A; Back, J J; Bagnasco, S; Bahinipati, S; Bailey, D S; Bailey, S; Bailly, P; van Bakel, N; Bakich, A M; Bala, A; Balagura, V; Baldini-Ferroli, R; Ban, Y; Banas, E; Band, H R; Banerjee, S; Baracchini, E; Barate, R; Barberio, E; Barbero, M; Bard, D J; Barillari, T; Barlow, N R; Barlow, R J; Barrett, M; Bartel, W; Bartelt, J; Bartoldus, R; Batignani, G; Battaglia, M; Bauer, J M; Bay, A; Beaulieu, M; Bechtle, P; Beck, T W; Becker, J; Becla, J; Bedny, I; Behari, S; Behera, P K; Behn, E; Behr, L; Beigbeder, C; Beiline, D; Bell, R; Bellini, F; Bellis, M; Bellodi, G; Belous, K; Benayoun, M; Benelli, G; Benitez, J F; Benkebil, M; Berger, N; Bernabeu, J; Bernard, D; Bernet, R; Bernlochner, F U; Berryhill, J W; Bertsche, K; Besson, P; Best, D S; Bettarini, S; Bettoni, D; Bhardwaj, V; Bhimji, W; Bhuyan, B; Biagini, M E; Biasini, M; van Bibber, K; Biesiada, J; Bingham, I; Bionta, R M; Bischofberger, M; Bitenc, U; Bizjak, I; Blanc, F; Blaylock, G; Blinov, V E; Bloom, E; Bloom, P C; Blount, N L; Blouw, J; Bly, M; Blyth, S; Boeheim, C T; Bomben, M; Bondar, A; Bondioli, M; Bonneaud, G R; Bonvicini, G; Booke, M; Booth, J; Borean, C; Borgland, A W; Borsato, E; Bosi, F; Bosisio, L; Botov, A A; Bougher, J; Bouldin, K; Bourgeois, P; Boutigny, D; Bowerman, D A; Boyarski, A M; Boyce, R F; Boyd, J T; Bozek, A; Bozzi, C; Bračko, M; Brandenburg, G; Brandt, T; Brau, B; Brau, J; Breon, A B; Breton, D; Brew, C; Briand, H; Bright-Thomas, P G; Brigljević, V; Britton, D I; Brochard, F; Broomer, B; Brose, J; Browder, T E; Brown, C L; Brown, C M; Brown, D N; Browne, M; Bruinsma, M; Brunet, S; Bucci, F; Buchanan, C; Buchmueller, O L; Bünger, C; Bugg, W; Bukin, A D; Bula, R; Bulten, H; Burchat, P R; Burgess, W; Burke, J P; Button-Shafer, J; Buzykaev, A R; Buzzo, A; Cai, Y; Calabrese, R; Calcaterra, A; Calderini, G; Camanzi, B; Campagna, E; Campagnari, C; Capra, R; Carassiti, V; Carpinelli, M; Carroll, M; Casarosa, G; Casey, B C K; Cason, N M; Castelli, G; Cavallo, N; Cavoto, G; Cecchi, A; Cenci, R; Cerizza, G; Cervelli, A; Ceseracciu, A; Chai, X; Chaisanguanthum, K S; Chang, M C; Chang, Y H; Chang, Y W; Chao, D S; Chao, M; Chao, Y; Charles, E; Chavez, C A; Cheaib, R; Chekelian, V; Chen, A; Chen, E; Chen, G P; Chen, H F; Chen, J -H; Chen, J C; Chen, K F; Chen, P; Chen, S; Chen, W T; Chen, X; Chen, X R; Chen, Y Q; Cheng, B; Cheon, B G; Chevalier, N; Chia, Y M; Chidzik, S; Chilikin, K; Chistiakova, M V; Cizeron, R; Cho, I S; Cho, K; Chobanova, V; Choi, H H F; Choi, K S; Choi, S K; Choi, Y; Choi, Y K; Christ, S; Chu, P H; Chun, S; Chuvikov, A; Cibinetto, G; Cinabro, D; Clark, A R; Clark, P J; Clarke, C K; Claus, R; Claxton, B; Clifton, Z C; Cochran, J; Cohen-Tanugi, J; Cohn, H; Colberg, T; Cole, S; Colecchia, F; Condurache, C; Contri, R; Convert, P; Convery, M R; Cooke, P; Copty, N; Cormack, C M; Corso, F Dal; Corwin, L A; Cossutti, F; Cote, D; Ramusino, A Cotta; Cottingham, W N; Couderc, F; Coupal, D P; Covarelli, R; Cowan, G; Craddock, W W; Crane, G; Crawley, H B; Cremaldi, L; Crescente, A; Cristinziani, M; Crnkovic, J; Crosetti, G; Cuhadar-Donszelmann, T; Cunha, A; Curry, S; D'Orazio, A; Dû, S; Dahlinger, G; Dahmes, B; Dallapiccola, C; Danielson, N; Danilov, M; Das, A; Dash, M; Dasu, S; Datta, M; Daudo, F; Dauncey, P D; David, P; Davis, C L; Day, C T; De Mori, F; De Domenico, G; De Groot, N; De la Vaissière, C; de la Vaissière, Ch; de Lesquen, A; De Nardo, G; de Sangro, R; De Silva, A; DeBarger, S; Decker, F J; Sanchez, P del Amo; Del Buono, L; Del Gamba, V; del Re, D; Della Ricca, G; Denig, A G; Derkach, D; Derrington, I M; DeStaebler, H; Destree, J; Devmal, S; Dey, B; Di Girolamo, B; Di Marco, E; Dickopp, M; Dima, M O; Dittrich, S; Dittongo, S; Dixon, P; Dneprovsky, L; Dohou, F; Doi, Y; Doležal, Z; Doll, D A; Donald, M; Dong, L; Dong, L Y; Dorfan, J; Dorigo, A; Dorsten, M P; Dowd, R; Dowdell, J; Drásal, Z; Dragic, J; Drummond, B W; Dubitzky, R S; Dubois-Felsmann, G P; Dubrovin, M S; Duh, Y C; Duh, Y T; Dujmic, D; Dungel, W; Dunwoodie, W; Dutta, D; Dvoretskii, A; Dyce, N; Ebert, M; Eckhart, E A; Ecklund, S; Eckmann, R; Eckstein, P; Edgar, C L; Edwards, A J; Egede, U; Eichenbaum, A M; Elmer, P; Emery, S; Enari, Y; Enomoto, R; Erdos, E; Erickson, R; Ernst, J A; Erwin, R J; Escalier, M; Eschenburg, V; Eschrich, I; Esen, S; Esteve, L; Evangelisti, F; Everton, C W; Eyges, V; Fabby, C; Fabozzi, F; Fahey, S; Falbo, M; Fan, S; Fang, F; Fanin, C; Farbin, A; Farhat, H; Fast, J E; Feindt, M; Fella, A; Feltresi, E; Ferber, T; Fernholz, R E; Ferrag, S; Ferrarotto, F; Ferroni, F; Field, R C; Filippi, A; Finocchiaro, G; Fioravanti, E; da Costa, J Firmino; Fischer, P -A; Fisher, A; Fisher, P H; Flacco, C J; Flack, R L; Flaecher, H U; Flanagan, J; Flanigan, J M; Ford, K E; Ford, W T; Forster, I J; Forti, A C; Forti, F; Fortin, D; Foster, B; Foulkes, S D; Fouque, G; Fox, J; Franchini, P; Sevilla, M Franco; Franek, B; Frank, E D; Fransham, K B; Fratina, S; Fratini, K; Frey, A; Frey, R; Friedl, M; Fritsch, M; Fry, J R; Fujii, H; Fujikawa, M; Fujita, Y; Fujiyama, Y; Fukunaga, C; Fukushima, M; Fullwood, J; Funahashi, Y; Funakoshi, Y; Furano, F; Furman, M; Furukawa, K; Futterschneider, H; Gabathuler, E; Gabriel, T A; Gabyshev, N; Gaede, F; Gagliardi, N; Gaidot, A; Gaillard, J -M; Gaillard, J R; Galagedera, S; Galeazzi, F; Gallo, F; Gamba, D; Gamet, R; Gan, K K; Gandini, P; Ganguly, S; Ganzhur, S F; Gao, Y Y; Gaponenko, I; Garmash, A; Tico, J Garra; Garzia, I; Gaspero, M; Gastaldi, F; Gatto, C; Gaur, V; Geddes, N I; Geld, T L; Genat, J -F; George, K A; George, M; George, S; Georgette, Z; Gershon, T J; Gill, M S; Gillard, R; Gilman, J D; Giordano, F; Giorgi, M A; Giraud, P -F; Gladney, L; Glanzman, T; Glattauer, R; Go, A; Goetzen, K; Goh, Y M; Gokhroo, G; Goldenzweig, P; Golubev, V B; Gopal, G P; Gordon, A; Gorišek, A; Goriletsky, V I; Gorodeisky, R; Gosset, L; Gotow, K; Gowdy, S J; Graffin, P; Grancagnolo, S; Grauges, E; Graziani, G; Green, M G; Greene, M G; Grenier, G J; Grenier, P; Griessinger, K; Grillo, A A; Grinyov, B V; Gritsan, A V; Grosdidier, G; Perdekamp, M Grosse; Grosso, P; Grothe, M; Groysman, Y; Grünberg, O; Guido, E; Guler, H; Gunawardane, N J W; Guo, Q H; Guo, R S; Guo, Z J; Guttman, N; Ha, H; Ha, H C; Haas, T; Haba, J; Hachtel, J; Hadavand, H K; Hadig, T; Hagner, C; Haire, M; Haitani, F; Haji, T; Haller, G; Halyo, V; Hamano, K; Hamasaki, H; de Monchenault, G Hamel; Hamilton, J; Hamilton, R; Hamon, O; Han, B Y; Han, Y L; Hanada, H; Hanagaki, K; Handa, F; Hanson, J E; Hanushevsky, A; Hara, K; Hara, T; Harada, Y; Harrison, P F; Harrison, T J; Harrop, B; Hart, A J; Hart, P A; Hartfiel, B L; Harton, J L; Haruyama, T; Hasan, A; Hasegawa, Y; Hast, C; Hastings, N C; Hasuko, K; Hauke, A; Hawkes, C M; Hayashi, K; Hazumi, M; Hee, C; Heenan, E M; Heffernan, D; Held, T; Henderson, R; Henderson, S W; Hertzbach, S S; Hervé, S; Heß, M; Heusch, C A; Hicheur, A; Higashi, Y; Higasino, Y; Higuchi, I; Hikita, S; Hill, E J; Himel, T; Hinz, L; Hirai, T; Hirano, H; Hirschauer, J F; Hitlin, D G; Hitomi, N; Hodgkinson, M C; Höcker, A; Hoi, C T; Hojo, T; Hokuue, T; Hollar, J J; Hong, T M; Honscheid, K; Hooberman, B; Hopkins, D A; Horii, Y; Hoshi, Y; Hoshina, K; Hou, S; Hou, W S; Hryn'ova, T; Hsiung, Y B; Hsu, C L; Hsu, S C; Hu, H; Hu, T; Huang, H C; Huang, T J; Huang, Y C; Huard, Z; Huffer, M E; Hufnagel, D; Hung, T; Hutchcroft, D E; Hyun, H J; Ichizawa, S; Igaki, T; Igarashi, A; Igarashi, S; Igarashi, Y; Igonkina, O; Ikado, K; Ikeda, H; Ikeda, K; Ilic, J; Inami, K; Innes, W R; Inoue, Y; Ishikawa, A; Ishino, H; Itagaki, K; Itami, S; Itoh, K; Ivanchenko, V N; Iverson, R; Iwabuchi, M; Iwai, G; Iwai, M; Iwaida, S; Iwamoto, M; Iwasaki, H; Iwasaki, M; Iwashita, T; Izen, J M; Jackson, D J; Jackson, F; Jackson, G; Jackson, P S; Jacobsen, R G; Jacoby, C; Jaegle, I; Jain, V; Jalocha, P; Jang, H K; Jasper, H; Jawahery, A; Jayatilleke, S; Jen, C M; Jensen, F; Jessop, C P; Ji, X B; John, M J J; Johnson, D R; Johnson, J R; Jolly, S; Jones, M; Joo, K K; Joshi, N; Joshi, N J; Judd, D; Julius, T; Kadel, R W; Kadyk, J A; Kagan, H; Kagan, R; Kah, D H; Kaiser, S; Kaji, H; Kajiwara, S; Kakuno, H; Kameshima, T; Kaminski, J; Kamitani, T; Kaneko, J; Kang, J H; Kang, J S; Kani, T; Kapusta, P; Karbach, T M; Karolak, M; Karyotakis, Y; Kasami, K; Katano, G; Kataoka, S U; Katayama, N; Kato, E; Kato, Y; Kawai, H; Kawai, M; Kawamura, N; Kawasaki, T; Kay, J; Kay, M; Kelly, M P; Kelsey, M H; Kent, N; Kerth, L T; Khan, A; Khan, H R; Kharakh, D; Kibayashi, A; Kichimi, H; Kiesling, C; Kikuchi, M; Kikutani, E; Kim, B H; Kim, C H; Kim, D W; Kim, H; Kim, H J; Kim, H O; Kim, H W; Kim, J B; Kim, J H; Kim, K T; Kim, M J; Kim, P; Kim, S K; Kim, S M; Kim, T H; Kim, Y I; Kim, Y J; King, G J; Kinoshita, K; Kirk, A; Kirkby, D; Kitayama, I; Klemetti, M; Klose, V; Klucar, J; Knecht, N S; Knoepfel, K J; Knowles, D J; Ko, B R; Kobayashi, N; Kobayashi, S; Kobayashi, T; Kobel, M J; Koblitz, S; Koch, H; Kocian, M L; Kodyš, P; Koeneke, K; Kofler, R; Koike, S; Koishi, S; Koiso, H; Kolb, J A; Kolya, S D; Kondo, Y; Konishi, H; Koppenburg, P; Koptchev, V B; Kordich, T M B; Korol, A A; Korotushenko, K; Korpar, S; Kouzes, R T; Kovalskyi, D; Kowalewski, R; Kozakai, Y; Kozanecki, W; Kral, J F; Krasnykh, A; Krause, R; Kravchenko, E A; Krebs, J; Kreisel, A; Kreps, M; Krishnamurthy, M; Kroeger, R; Kroeger, W; Krokovny, P; Kronenbitter, B; Kroseberg, J; Kubo, T; Kuhr, T; Kukartsev, G; Kulasiri, R; Kulikov, A; Kumar, R; Kumar, S; Kumita, T; Kuniya, T; Kunze, M; Kuo, C C; Kuo, T -L; Kurashiro, H; Kurihara, E; Kurita, N; Kuroki, Y; Kurup, A; Kutter, P E; Kuznetsova, N; Kvasnička, P; Kyberd, P; Kyeong, S H; Lacker, H M; Lae, C K; Lamanna, E; Lamsa, J; Lanceri, L; Landi, L; Lang, M I; Lange, D J; Lange, J S; Langenegger, U; Langer, M; Lankford, A J; Lanni, F; Laplace, S; Latour, E; Lau, Y P; Lavin, D R; Layter, J; Lebbolo, H; LeClerc, C; Leddig, T; Leder, G; Diberder, F Le; Lee, C L; Lee, J; Lee, J S; Lee, M C; Lee, M H; Lee, M J; Lee, S -J; Lee, S E; Lee, S H; Lee, Y J; Lees, J P; Legendre, M; Leitgab, M; Leitner, R; Leonardi, E; Leonidopoulos, C; Lepeltier, V; Leruste, Ph; Lesiak, T; Levi, M E; Levy, S L; Lewandowski, B; Lewczuk, M J; Lewis, P; Li, H; Li, H B; Li, S; Li, X; Li, Y; Gioi, L Li; Libby, J; Lidbury, J; Lillard, V; Lim, C L; Limosani, A; Lin, C S; Lin, J Y; Lin, S W; Lin, Y S; Lindquist, B; Lindsay, C; Lista, L; Liu, C; Liu, F; Liu, H; Liu, H M; Liu, J; Liu, R; Liu, T; Liu, Y; Liu, Z Q; Liventsev, D; Vetere, M Lo; Locke, C B; Lockman, W S; Di Lodovico, F; Lombardo, V; London, G W; Pegna, D Lopes; Lopez, L; Lopez-March, N; Lory, J; LoSecco, J M; Lou, X C; Louvot, R; Lu, A; Lu, C; Lu, M; Lu, R S; Lueck, T; Luitz, S; Lukin, P; Lund, P; Luppi, E; Lutz, A M; Lutz, O; Lynch, G; Lynch, H L; Lyon, A J; Lyubinsky, V R; MacFarlane, D B; Mackay, C; MacNaughton, J; Macri, M M; Madani, S; Mader, W F; Majewski, S A; Majumder, G; Makida, Y; Malaescu, B; Malaguti, R; Malclès, J; Mallik, U; Maly, E; Mamada, H; Manabe, A; Mancinelli, G; Mandelkern, M; Mandl, F; Manfredi, P F; Mangeol, D J J; Manoni, E; Mao, Z P; Margoni, M; Marker, C E; Markey, G; Marks, J; Marlow, D; Marques, V; Marsiske, H; Martellotti, S; Martin, E C; Martin, J P; Martin, L; Martinez, A J; Marzolla, M; Mass, A; Masuzawa, M; Mathieu, A; Matricon, P; Matsubara, T; Matsuda, T; Matsumoto, H; Matsumoto, S; Matsumoto, T; Matsuo, H; Mattison, T S; Matvienko, D; Matyja, A; Mayer, B; Mazur, M A; Mazzoni, M A; McCulloch, M; McDonald, J; McFall, J D; McGrath, P; McKemey, A K; McKenna, J A; Mclachlin, S E; McMahon, S; McMahon, T R; McOnie, S; Medvedeva, T; Melen, R; Mellado, B; Menges, W; Menke, S; Merchant, A M; Merkel, J; Messner, R; Metcalfe, S; Metzler, S; Meyer, N T; Meyer, T I; Meyer, W T; Michael, A K; Michelon, G; Michizono, S; Micout, P; Miftakov, V; Mihalyi, A; Mikami, Y; Milanes, D A; Milek, M; Mimashi, T; Minamora, J S; Mindas, C; Minutoli, S; Mir, L M; Mishra, K; Mitaroff, W; Miyake, H; Miyashita, T S; Miyata, H; Miyazaki, Y; Moffitt, L C; Mohapatra, A; Mohapatra, A K; Mohapatra, D; Moll, A; Moloney, G R; Mols, J P; Mommsen, R K; Monge, M R; Monorchio, D; Moore, T B; Moorhead, G F; de Freitas, P Mora; Morandin, M; Morgan, N; Morgan, S E; Morganti, M; Morganti, S; Mori, S; Mori, T; Morii, M; Morris, J P; Morsani, F; Morton, G W; Moss, L J; Mouly, J P; Mount, R; Mueller, J; Müller-Pfefferkorn, R; Mugge, M; Muheim, F; Muir, A; Mullin, E; Munerato, M; Murakami, A; Murakami, T; Muramatsu, N; Musico, P; Nagai, I; Nagamine, T; Nagasaka, Y; Nagashima, Y; Nagayama, S; Nagel, M; Naisbit, M T; Nakadaira, T; Nakahama, Y; Nakajima, M; Nakajima, T; Nakamura, I; Nakamura, T; Nakamura, T T; Nakano, E; Nakayama, H; Nam, J W; Narita, S; Narsky, I; Nash, J A; Natkaniec, Z; Nauenberg, U; Nayak, M; Neal, H; Nedelkovska, E; Negrini, M; Neichi, K; Nelson, D; Nelson, S; Neri, N; Nesom, G; Neubauer, S; Newman-Coburn, D; Ng, C; Nguyen, X; Nicholson, H; Niebuhr, C; Nief, J Y; Niiyama, M; Nikolich, M B; Nisar, N K; Nishimura, K; Nishio, Y; Nitoh, O; Nogowski, R; Noguchi, S; Nomura, T; Nordby, M; Nosochkov, Y; Novokhatski, A; Nozaki, S; Nozaki, T; Nugent, I M; O'Grady, C P; O'Neale, S W; O'Neill, F G; Oberhof, B; Oddone, P J; Ofte, I; Ogawa, A; Ogawa, K; Ogawa, S; Ogawa, Y; Ohkubo, R; Ohmi, K; Ohnishi, Y; Ohno, F; Ohshima, T; Ohshima, Y; Ohuchi, N; Oide, K; Oishi, N; Okabe, T; Okazaki, N; Okazaki, T; Okuno, S; Olaiya, E O; Olivas, A; Olley, P; Olsen, J; Ono, S; Onorato, G; Onuchin, A P; Onuki, Y; Ooba, T; Orimoto, T J; Oshima, T; Osipenkov, I L; Ostrowicz, W; Oswald, C; Otto, S; Oyang, J; Oyanguren, A; Ozaki, H; Ozcan, V E; Paar, H P; Padoan, C; Paick, K; Palka, H; Pan, B; Pan, Y; Vazquez, W Panduro; Panetta, J; Panova, A I; Panvini, R S; Panzenböck, E; Paoloni, E; Paolucci, P; Pappagallo, M; Paramesvaran, S; Park, C S; Park, C W; Park, H; Park, H K; Park, K S; Park, W; Parry, R J; Parslow, N; Passaggio, S; Pastore, F C; Patel, P M; Patrignani, C; Patteri, P; Pavel, T; Pavlovich, J; Payne, D J; Peak, L S; Peimer, D R; Pelizaeus, M; Pellegrini, R; Pelliccioni, M; Peng, C C; Peng, J C; Peng, K C; Peng, T; Penichot, Y; Pennazzi, S; Pennington, M R; Penny, R C; Penzkofer, A; Perazzo, A; Perez, A; Perl, M; Pernicka, M; Perroud, J -P; Peruzzi, I M; Pestotnik, R; Peters, K; Peters, M; Petersen, B A; Petersen, T C; Petigura, E; Petrak, S; Petrella, A; Petrič, M; Petzold, A; Pia, M G; Piatenko, T; Piccolo, D; Piccolo, M; Piemontese, L; Piemontese, M; Pierini, M; Pierson, S; Pioppi, M; Piredda, G; Pivk, M; Plaszczynski, S; Polci, F; Pompili, A; Poropat, P; Posocco, M; Potter, C T; Potter, R J L; Prasad, V; Prebys, E; Prencipe, E; Prendki, J; Prepost, R; Prest, M; Prim, M; Pripstein, M; Prudent, X; Pruvot, S; Puccio, E M T; Purohit, M V; Qi, N D; Quinn, H; Raaf, J; Rabberman, R; Raffaelli, F; Ragghianti, G; Rahatlou, S; Rahimi, A M; Rahmat, R; Rakitin, A Y; Randle-Conde, A; Rankin, P; Rashevskaya, I; Ratkovsky, S; Raven, G; Re, V; Reep, M; Regensburger, J J; Reidy, J; Reif, R; Reisert, B; Renard, C; Renga, F; Ricciardi, S; Richman, J D; Ritchie, J L; Ritter, M; Rivetta, C; Rizzo, G; Roat, C; Robbe, P; Roberts, D A; Robertson, A I; Robutti, E; Rodier, S; Rodriguez, D M; Rodriguez, J L; Rodriguez, R; Roe, N A; Röhrken, M; Roethel, W; Rolquin, J; Romanov, L; Romosan, A; Ronan, M T; Rong, G; Ronga, F J; Roos, L; Root, N; Rosen, M; Rosenberg, E I; Rossi, A; Rostomyan, A; Rotondo, M; Roussot, E; Roy, J; Rozanska, M; Rozen, Y; Rubin, A E; Ruddick, W O; Ruland, A M; Rybicki, K; Ryd, A; Ryu, S; Ryuko, J; Sabik, S; Sacco, R; Saeed, M A; Tehrani, F Safai; Sagawa, H; Sahoo, H; Sahu, S; Saigo, M; Saito, T; Saitoh, S; Sakai, K; Sakamoto, H; Sakaue, H; Saleem, M; Salnikov, A A; Salvati, E; Salvatore, F; Samuel, A; Sanders, D A; Sanders, P; Sandilya, S; Sandrelli, F; Sands, W; Sands, W R; Sanpei, M; Santel, D; Santelj, L; Santoro, V; Santroni, A; Sanuki, T; Sarangi, T R; Saremi, S; Sarti, A; Sasaki, T; Sasao, N; Satapathy, M; Sato, Nobuhiko; Sato, Noriaki; Sato, Y; Satoyama, N; Satpathy, A; Savinov, V; Savvas, N; Saxton, O H; Sayeed, K; Schaffner, S F; Schalk, T; Schenk, S; Schieck, J R; Schietinger, T; Schilling, C J; Schindler, R H; Schmid, S; Schmitz, R E; Schmuecker, H; Schneider, O; Schnell, G; Schönmeier, P; Schofield, K C; Schott, G; Schröder, H; Schram, M; Schubert, J; Schümann, J; Schultz, J; Schumm, B A; Schune, M H; Schwanke, U; Schwarz, H; Schwiening, J; Schwierz, R; Schwitters, R F; Sciacca, C; Sciolla, G; Scott, I J; Seeman, J; Seiden, A; Seitz, R; Seki, T; Sekiya, A I; Semenov, S; Semmler, D; Sen, S; Senyo, K; Seon, O; Serbo, V V; Serednyakov, S I; Serfass, B; Serra, M; Serrano, J; Settai, Y; Seuster, R; Sevior, M E; Shakhova, K V; Shang, L; Shapkin, M; Sharma, V; Shebalin, V; Shelkov, V G; Shen, B C; Shen, D Z; Shen, Y T; Sherwood, D J; Shibata, T; Shibata, T A; Shibuya, H; Shidara, T; Shimada, K; Shimoyama, M; Shinomiya, S; Shiu, J G; Shorthouse, H W; Shpilinskaya, L I; Sibidanov, A; Sicard, E; Sidorov, A; Sidorov, V; Siegle, V; Sigamani, M; Simani, M C; Simard, M; Simi, G; Simon, F; Simonetto, F; Sinev, N B; Singh, H; Singh, J B; Sinha, R; Sitt, S; Skovpen, Yu I; Sloane, R J; Smerkol, P; Smith, A J S; Smith, D; Smith, D S; Smith, J G; Smol, A; Snoek, H L; Snyder, A; So, R Y; Sobie, R J; Soderstrom, E; Soha, A; Sohn, Y S; Sokoloff, M D; Sokolov, A; Solagna, P; Solovieva, E; Soni, N; Sonnek, P; Sordini, V; Spaan, B; Spanier, S M; Spencer, E; Speziali, V; Spitznagel, M; Spradlin, P; Staengle, H; Stamen, R; Stanek, M; Stanič, S; Stark, J; Steder, M; Steininger, H; Steinke, M; Stelzer, J; Stevanato, E; Stocchi, A; Stock, R; Stoeck, H; Stoker, D P; Stroili, R; Strom, D; Strother, P; Strube, J; Stugu, B; Stypula, J; Su, D; Suda, R; Sugahara, R; Sugi, A; Sugimura, T; Sugiyama, A; Suitoh, S; Sullivan, M K; Sumihama, M; Sumiyoshi, T; Summers, D J; Sun, L; Sun, S; Sundermann, J E; Sung, H F; Susaki, Y; Sutcliffe, P; Suzuki, A; Suzuki, J; Suzuki, J I; Suzuki, K; Suzuki, S; Suzuki, S Y; Swain, J E; Swain, S K; T'Jampens, S; Tabata, M; Tackmann, K; Tajima, H; Tajima, O; Takahashi, K; Takahashi, S; Takahashi, T; Takasaki, F; Takayama, T; Takita, M; Tamai, K; Tamponi, U; Tamura, N; Tan, N; Tan, P; Tanabe, K; Tanabe, T; Tanaka, H A; Tanaka, J; Tanaka, M; Tanaka, S; Tanaka, Y; Tanida, K; Taniguchi, N; Taras, P; Tasneem, N; Tatishvili, G; Tatomi, T; Tawada, M; Taylor, F; Taylor, G N; Taylor, G P; Telnov, V I; Teodorescu, L; Ter-Antonyan, R; Teramoto, Y; Teytelman, D; Thérin, G; Thiebaux, Ch; Thiessen, D; Thomas, E W; Thompson, J M; Thorne, F; Tian, X C; Tibbetts, M; Tikhomirov, I; Tinslay, J S; Tiozzo, G; Tisserand, V; Tocut, V; Toki, W H; Tomassini, E W; Tomoto, M; Tomura, T; Torassa, E; Torrence, E; Tosi, S; Touramanis, C; Toussaint, J C; Tovey, S N; Trapani, P P; Treadwell, E; Triggiani, G; Trincaz-Duvoid, S; Trischuk, W; Troost, D; Trunov, A; Tsai, K L; Tsai, Y T; Tsujita, Y; Tsukada, K; Tsukamoto, T; Tuggle, J M; Tumanov, A; Tung, Y W; Turnbull, L; Turner, J; Turri, M; Uchida, K; Uchida, M; Uchida, Y; Ueki, M; Ueno, K; Ujiie, N; Ulmer, K A; Unno, Y; Urquijo, P; Ushiroda, Y; Usov, Y; Usseglio, M; Usuki, Y; Uwer, U; Va'vra, J; Vahsen, S E; Vaitsas, G; Valassi, A; Vallazza, E; Vallereau, A; Vanhoefer, P; van Hoek, W C; Van Hulse, C; van Winkle, D; Varner, G; Varnes, E W; Varvell, K E; Vasileiadis, G; Velikzhanin, Y S; Verderi, M; Versillé, S; Vervink, K; Viaud, B; Vidal, P B; Villa, S; Villanueva-Perez, P; Vinograd, E L; Vitale, L; Vitug, G M; Voß, C; Voci, C; Voena, C; Volk, A; von Wimmersperg-Toeller, J H; Vorobyev, V; Vossen, A; Vuagnin, G; Vuosalo, C O; Wacker, K; Wagner, A P; Wagner, D L; Wagner, G; Wagner, M N; Wagner, S R; Wagoner, D E; Walker, D; Walkowiak, W; Wallom, D; Wang, C C; Wang, C H; Wang, J; Wang, J G; Wang, K; Wang, L; Wang, L L; Wang, P; Wang, T J; Wang, W F; Wang, X L; Wang, Y F; Wappler, F R; Watanabe, M; Watson, A T; Watson, J E; Watson, N K; Watt, M; Weatherall, J H; Weaver, M; Weber, T; Wedd, R; Wei, J T; Weidemann, A W; W, A J R; Wenzel, W A; West, C A; West, C G; West, T J; White, R M; Wicht, J; Widhalm, L; Wiechczynski, J; Wienands, U; Wilden, L; Wilder, M; Williams, D C; Williams, G; Williams, J C; Williams, K M; Williams, M I; Willocq, S Y; Wilson, J R; Wilson, M G; Wilson, R J; Winklmeier, F; Winter, M A; Wisniewski, W J; Wittgen, M; Wittlin, J; Wittmer, W; Wixted, R; Woch, A; Wogsland, B J; Wong, Q K; Wray, B C; Wren, A C; Wright, D M; Wu, C H; Wu, J; Wu, S L; Wulsin, H W; Xella, S M; Xie, Q L; Xie, Y; Xu, Z Z; Yèche, Ch; Yamada, Y; Yamaga, M; Yamaguchi, A; Yamaguchi, H; Yamaki, T; Yamamoto, H; Yamamoto, N; Yamamoto, R K; Yamamoto, S; Yamanaka, T; Yamaoka, H; Yamaoka, J; Yamaoka, Y; Yamashita, Y; Yamauchi, M; Yan, D S; Yan, Y; Yanai, H; Yanaka, S; Yang, H; Yang, R; Yang, S; Yarritu, A K; Yashchenko, S; Yashima, J; Yasin, Z; Yasu, Y; Ye, S W; Yeh, P; Yi, J I; Yi, K; Yi, M; Yin, Z W; Ying, J; Yocky, G; Yokoyama, K; Yokoyama, M; Yokoyama, T; Yoshida, K; Yoshida, M; Yoshimura, Y; Young, C C; Yu, C X; Yu, Z; Yuan, C Z; Yuan, Y; Yumiceva, F X; Yusa, Y; Yushkov, A N; Yuta, H; Zacek, V; Zain, S B; Zallo, A; Zambito, S; Zander, D; Zang, S L; Zanin, D; Zaslavsky, B G; Zeng, Q L; Zghiche, A; Zhang, B; Zhang, J; Zhang, L; Zhang, L M; Zhang, S Q; Zhang, Z P; Zhao, H W; Zhao, M; Zhao, Z G; Zheng, Y; Zheng, Y H; Zheng, Z P; Zhilich, V; Zhou, P; Zhu, R Y; Zhu, Y S; Zhu, Z M; Zhulanov, V; Ziegler, T; Ziegler, V; Zioulas, G; Zisman, M; Zito, M; Zürcher, D; Zwahlen, N; Zyukova, O; Živko, T; Žontar, D; Bevan, Adrian; Golob, Bostjan; Mannel, Thomas; Prell, Soeren; Yabsley, Bruce

    2014-01-01

    This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C.

  12. The enzymology of polyether biosynthesis.

    Science.gov (United States)

    Liu, Tiangang; Cane, David E; Deng, Zixin

    2009-01-01

    Polyether ionophore antibiotics are a special class of polyketides widely used in veterinary medicine, and as food additives in animal husbandry. In this article, we review current knowledge about the mechanism of polyether biosynthesis, and the genetic and biochemical strategies used for its study. Several clear differences distinguish it from traditional type I modular polyketide biosynthesis: polyether backbones are assembled by modular polyketide synthases but are modified by two key enzymes, epoxidase and epoxide hydrolase, to generate the product. All double bonds involved in the oxidative cyclization in the polyketide backbone are of E geometry. Chain release in the polyether biosynthetic pathway requires a special type II thioesterase which specifically hydrolyzes the polyether thioester. All these discoveries should be very helpful for a deep understanding of the biosynthetic mechanism of this class of important natural compounds, and for the targeted engineering of polyether derivatives.

  13. DGAT enzymes and triacylglycerol biosynthesis

    OpenAIRE

    Yen, Chi-Liang Eric; Stone, Scot J.; Koliwad, Suneil; Harris, Charles; Farese, Robert V.

    2008-01-01

    Triacylglycerols (triglycerides) (TGs) are the major storage molecules of metabolic energy and FAs in most living organisms. Excessive accumulation of TGs, however, is associated with human diseases, such as obesity, diabetes mellitus, and steatohepatitis. The final and the only committed step in the biosynthesis of TGs is catalyzed by acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes. The genes encoding two DGAT enzymes, DGAT1 and DGAT2, were identified in the past decade, ...

  14. Commercializing Biorefinery Technology: A Case for the Multi-Product Pathway to a Viable Biorefinery

    Directory of Open Access Journals (Sweden)

    Shijie Liu

    2011-11-01

    Full Text Available While there may be many reasons why very interesting science ideas never reach commercial practice, one of the more prevalent is that the reaction or process, which is scientifically possible, cannot be made efficient enough to achieve economic viability. One pathway to economic viability for many business sectors is the multi-product portfolio. Research, development, and deployment of viable biorefinery technology must meld sound science with engineering and business economics. It is virtually axiomatic that increased value can be generated by isolating relatively pure substances from heterogeneous raw materials. Woody biomass is a heterogeneous raw material consisting of the major structural components, cellulose, lignin, and hemicelluloses, as well as minor components, such as extractives and ash. Cellulose is a linear homopolymer of D-glucopyrano-units with β-D(1®4 connections and is the wood component most resistant to chemical and biological degradation. Lignin is a macromolecule of phenylpropanoid units, second to cellulose in bio-resistance, and is the key component that is sought for removal from woody biomass in chemical pulping. Hemicelluloses are a collection of heteropolysaccharides, comprised mainly of 5- and 6-carbon sugars. Extractives, some of which have high commercial value, are a collection of low molecular weight organic and inorganic woody materials that can be removed, to some extent, under mild conditions. Applied Biorefinery Sciences, LLC (a private, New York, USA based company is commercializing a value-optimization pathway (the ABS Process™ for generating a multi-product portfolio by isolating and recovering homogeneous substances from each of the above mentioned major and minor woody biomass components. The ABS Process™ incorporates the patent pending, core biorefinery technology, “hot water extraction”, as developed at the State University of New York College of Environmental Science and Forestry (SUNY

  15. Mathematical modeling of a multi-product EMQ model with an enhanced end items issuing policy and failures in rework.

    Science.gov (United States)

    Chiu, Yuan-Shyi Peter; Sung, Peng-Cheng; Chiu, Singa Wang; Chou, Chung-Li

    2015-01-01

    This study uses mathematical modeling to examine a multi-product economic manufacturing quantity (EMQ) model with an enhanced end items issuing policy and rework failures. We assume that a multi-product EMQ model randomly generates nonconforming items. All of the defective are reworked, but a certain portion fails and becomes scraps. When rework process ends and the entire lot of each product is quality assured, a cost reduction n + 1 end items issuing policy is used to transport finished items of each product. As a result, a closed-form optimal production cycle time is obtained. A numerical example demonstrates the practical usage of our result and confirms a significant savings in stock holding and overall production costs as compared to that of a prior work (Chiu et al. in J Sci Ind Res India, 72:435-440 2013) in the literature.

  16. Factorials of real negative and imaginary numbers - A new perspective.

    Science.gov (United States)

    Thukral, Ashwani K

    2014-01-01

    Presently, factorials of real negative numbers and imaginary numbers, except for zero and negative integers are interpolated using the Euler's gamma function. In the present paper, the concept of factorials has been generalised as applicable to real and imaginary numbers, and multifactorials. New functions based on Euler's factorial function have been proposed for the factorials of real negative and imaginary numbers. As per the present concept, the factorials of real negative numbers, are complex numbers. The factorials of real negative integers have their imaginary part equal to zero, thus are real numbers. Similarly, the factorials of imaginary numbers are complex numbers. The moduli of the complex factorials of real negative numbers, and imaginary numbers are equal to their respective real positive number factorials. Fractional factorials and multifactorials have been defined in a new perspective. The proposed concept has also been extended to Euler's gamma function for real negative numbers and imaginary numbers, and beta function.

  17. Analysis of scaled-factorial-moment data

    International Nuclear Information System (INIS)

    Seibert, D.

    1990-01-01

    We discuss the two standard constructions used in the search for intermittency, the exclusive and inclusive scaled factorial moments. We propose the use of a new scaled factorial moment that reduces to the exclusive moment in the appropriate limit and is free of undesirable multiplicity correlations that are contained in the inclusive moment. We show that there are some similarities among most of the models that have been proposed to explain factorial-moment data, and that these similarities can be used to increase the efficiency of testing these models. We begin by calculating factorial moments from a simple independent-cluster model that assumes only approximate boost invariance of the cluster rapidity distribution and an approximate relation among the moments of the cluster multiplicity distribution. We find two scaling laws that are essentially model independent. The first scaling law relates the moments to each other with a simple formula, indicating that the different factorial moments are not independent. The second scaling law relates samples with different rapidity densities. We find evidence for much larger clusters in heavy-ion data than in light-ion data, indicating possible spatial intermittency in the heavy-ion events

  18. Baby factories taint surrogacy in Nigeria.

    Science.gov (United States)

    Makinde, Olusesan Ayodeji; Makinde, Olufunmbi Olukemi; Olaleye, Olalekan; Brown, Brandon; Odimegwu, Clifford O

    2016-01-01

    The practice of reproductive medicine in Nigeria is facing new challenges with the proliferation of 'baby factories'. Baby factories are buildings, hospitals or orphanages that have been converted into places for young girls and women to give birth to children for sale on the black market, often to infertile couples, or into trafficking rings. This practice illegally provides outcomes (children) similar to surrogacy. While surrogacy has not been well accepted in this environment, the proliferation of baby factories further threatens its acceptance. The involvement of medical and allied health workers in the operation of baby factories raises ethical concerns. The lack of a properly defined legal framework and code of practice for surrogacy makes it difficult to prosecute baby factory owners, especially when they are health workers claiming to be providing services to clients. In this environment, surrogacy and other assisted reproductive techniques urgently require regulation in order to define when ethico-legal lines have been crossed in providing surrogacy or surrogacy-like services. Copyright © 2015 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  19. ADVANCED MULTI-PRODUCT COAL UTILIZATION BY-PRODUCT PROCESSING PLANT

    Energy Technology Data Exchange (ETDEWEB)

    Robert Jewell; Thomas Robl; John Groppo

    2005-03-01

    The objective of the project is to build a multi-product ash beneficiation plant at Kentucky Utilities 2,200-MW Ghent Generating Station, located in Carroll County, Kentucky. This part of the study includes the examination of the feedstocks for the beneficiation plant. The ash, as produced by the plant, and that stored in the lower pond were examined. The ash produced by the plant was found to be highly variable as the plant consumes high and low sulfur bituminous coal, in Units 1 and 2 and a mixture of subbituminous and bituminous coal in Units 3 and 4. The ash produced reflected this consisting of an iron-rich ({approx}24%, Fe{sub 2}O{sub 3}), aluminum rich ({approx}29% Al{sub 2}O{sub 3}) and high calcium (6%-7%, CaO) ash, respectively. The LOI of the ash typically was in the range of 5.5% to 6.5%, but individual samples ranged from 1% to almost 9%. The lower pond at Ghent is a substantial body, covering more than 100 acres, with a volume that exceeds 200 million cubic feet. The sedimentation, stratigraphy and resource assessment of the in place ash was investigated with vibracoring and three-dimensional, computer-modeling techniques. Thirteen cores to depths reaching nearly 40 feet, were retrieved, logged in the field and transported to the lab for a series of analyses for particle size, loss on ignition, petrography, x-ray diffraction, and x-ray fluorescence. Collected data were processed using ArcViewGIS, Rockware, and Microsoft Excel to create three-dimensional, layered iso-grade maps, as well as stratigraphic columns and profiles, and reserve estimations. The ash in the pond was projected to exceed 7 million tons and contain over 1.5 million tons of coarse carbon, and 1.8 million tons of fine (<10 {micro}m) glassy pozzolanic material. The size, quality and consistency of the ponded material suggests that it is the better feedstock for the beneficiation plant.

  20. Pseudomonas putida as a microbial cell factory

    DEFF Research Database (Denmark)

    Wigneswaran, Vinoth

    for sustainable production of chemicals, which can be achieved by microbial cell factories. The work presented in this PhD thesis elucidates the application of Pseudomonas putida as a microbial cell factory for production of the biosurfactant rhamnolipid. The rhamnolipid production was achieved by heterologous...... phase. The genomic alterations were identified by genome sequencing and revealed parallel evolution. Glycerol was also shown to be able to support biofilm growth and as a result of this it can be used as an alternative substrate for producing biochemicals in conventional and biofilm reactors. The use...... of biofilm as a production platform and the usage of glycerol as a feedstock show the potential of using microbial cell factories in the transition toward sustainable production of chemicals. Particularly, the applicability of biofilm as a production platform can emerge as a promising alternative...

  1. Ergonomic analysis jobs in recovered factories.

    Science.gov (United States)

    Cuenca, Gabriela; Zotta, Gastón

    2012-01-01

    With the advent of the deep economic crisis in Argentina on 2001, the recovery of companies through to the creation of the Cooperatives Working Self-Management or Factories Recovered by its workers was constituted as one of the ways in which the salaried disobeyed the increasing unemployment. When the companies turn into recovered factories they tend to leave of side practices that have been seen like imposed by the previous organization and not understanding them as a primary condition for the execution of his tasks. Safety and ergonomics are two disciplines that are no longer considered relevant to the daily work. Therefore this investigation aims to revalue, undergo semantic to give back to a place in every organization analyzed. This research developed a self-diagnostic tool for working conditions, and the environment, present in the recovered factories.

  2. A conceptual design of circular Higgs factory

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Yunhai

    2016-11-30

    Similar to a super B-factory, a circular Higgs factory (CHF) will require strong focusing systems near the interaction points and a low-emittance lattice in the arcs to achieve a factory luminosity. At electron beam energy of 125 GeV, beamstrahlung effects during the collision pose an additional challenge to the collider design. In particular, a large momentum acceptance at the 2% level is necessary to retain an adequate beam lifetime. This turns out to be the most challenging aspect in the design of a CHF. In this paper, an example will be provided to illustrate the beam dynamics in a CHF, emphasizing the chromatic optics. Basic optical modules and advanced analysis will be presented. Most importantly, we will show that 2% momentum aperture is achievable.

  3. Hadronic atoms at a kaon factory

    International Nuclear Information System (INIS)

    Leon, M.

    1982-01-01

    Beyond doubt, the advent of a kaon factory will be of immense significance for the study of hadronic atoms. Here we will discuss some classes of experiments that certainly can and will be done at a kaon factory, as well as some very interesting possibilities which deserve investigation. Among the certains we include the observation of hadronic x rays from kaonic and μ - atoms, for both Z greater than one and for the isotopes of hydrogen, mainly for strong interaction information. More conjectural is the possibility of measuring Xi - and Ω - x rays

  4. Nuclear physics at the KAON factory

    International Nuclear Information System (INIS)

    Kitching, R.

    1989-05-01

    The author surveys the range of nuclear physics issues which can be addressed with a high intensity hadron facility such as the KAON factory. He discusses hadron spectroscopy, kaon scattering, hypernuclear physics, spin physics, and nuclear physics with neutrinos. Nuclear Physics is defined rather broadly, encompassing the study of strongly interacting systems, and including the structure of individual hadrons, hadron-hadron interactions, hadronic weak and electromagnetic currents (in nuclei too), conventional nuclear structure, and exotic nuclei. The basic theme is how the KAON Factory can shed light on non-perturbative QCD and its relation to conventional nuclear physics

  5. Particle physics prospects for the KAON factory

    International Nuclear Information System (INIS)

    Bryman, D.

    1989-05-01

    The Kaon Factory at TRIUMF will produce beams of kaons, antiprotons, neutrinos and other particles with a hundred-fold increase in intensity over existing machines in the 30 GeV region. This will make possible new high precision experiments designed to test current ideas as well as high sensitivity measurements which could potentially reveal new effects. A sample of particle physics experiments involving rare kaon decays, CP and T violation studies, neutrino properties and reactions and light quark spectroscopy which might take advantage of the new opportunities presented by the Kaon Factory is discussed

  6. Oleic acid biosynthesis in cyanobacteria

    International Nuclear Information System (INIS)

    VanDusen, W.J.; Jaworski, J.G.

    1986-01-01

    The biosynthesis of fatty acids in cyanobacteria is very similar to the well characterized system found in green plants. However, the initial desaturation of stearic acid in cyanobacteria appears to represent a significant departure from plant systems in which stearoyl-ACP is the exclusive substrate for desaturation. In Anabaena variabilis, the substrate appears to be monoglucosyldiacylglycerol, a lipid not found in plants. The authors examined five different cyanobacteria to determine if the pathway in A. variabilis was generally present in other cyanobacteria. The cyanobacteria studied were A. variabilis, Chlorogloeopsis sp., Schizothrix calcicola, Anacystis marina, and Anacystis nidulans. Each were grown in liquid culture, harvested, and examined for stearoyl-ACP desaturase activity or incubated with 14 CO 2 . None of the cyanobacteria contained any stearoyl-ACP desaturase activity in whole homogenates or 105,000g supernatants. All were capable of incorporating 14 CO 2 into monoglucosyldiacylglycerol and results from incubations of 20 min, 1 hr, 1 hr + 10 hr chase were consistent with monoglucosyldiacylglycerol serving as precursor for monogalctosyldiacylglycerol. Thus, initial evidence is consistent with oleic acid biosynthesis occurring by desaturation of stearoyl-monoglucosyldiacylglycerol in all cyanobacteria

  7. BERKELEY/STANFORD: B factory plans

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    For the past several years, accelerator physicists at Lawrence Berkeley Laboratory (LBL) and the Stanford Linear Accelerator Center (SLAC) have been involved in the design of an Asymmetric B Factory to be sited in the tunnel of the PEP electron-positron collider at SLAC

  8. KEKB B-Factory, the luminosity frontier

    International Nuclear Information System (INIS)

    Oide, Katsunobu

    2009-01-01

    The experiment at the KEKB B-Factory, as well as PEP-II, brought the final blow on the 2008 Nobel Prize in Physics for the Kobayashi-Maskawa theory. A few key issues will be described on the design and performance of KEKB to make the world's highest luminosity possible. (author)

  9. The Low-Energy Neutrino Factory

    International Nuclear Information System (INIS)

    Brass, Alan; Geer, Steve; Ellis, Malcolm; Mena, Olga; Pascoli, Silvia

    2008-01-01

    To date most studies of Neutrino Factories have focused on facilities where the energy of the muon in the storage ring has been in the range of 25-50 GeV. In this paper we present a concept for a Low-Energy (∼ 4 GeV) neutrino factory. For baselines of O(1000 km), the rich oscillation pattern at low neutrino interaction energy (0.5 - ∼3 GeV) provides the unique performance of this facility with regard to its sensitivity to CP violation and the determination of the neutrino mass hierarchy. A unique neutrino detector is needed, however, in order to exploit this oscillation pattern. We will describe the basic accelerator facility, demonstrate the methodology of the analysis and give an estimate on how well the Low-Energy neutrino factory can measure θ 13 , CP violation and the mass hierarchy. We will also describe the detector concept that is used, show a preliminary analysis regarding its performance and indicate what R and D is still needed. Finally we will show how the Low-Energy neutrino factory could be a step towards an energy frontier muon collider.

  10. The Energy Factory; EnergieFabriek

    Energy Technology Data Exchange (ETDEWEB)

    Van den Boomen, M.; Van den Dungen, G.J.; Elias, T.; Jansen, M. [Universiteit van Amsterdam UvA, Amsterdam (Netherlands)

    2009-05-15

    The Energy Factory is a collaboration of 26 Dutch local water boards in which options for energy saving and energy production are examined. According to the authors, the initiative of the Energy Factory will lead to a reframing of the role of the water boards. Moreover, they explain how the PPP concept (People, Planet, Profit) may act as platform for negotiations between actors who are involved in the Energy Factory. In addition, the PPP concept is used to demonstrate that the Energy Factory will lead to larger social involvement, social entrepreneurship and growing profits [Dutch] De Energiefabriek is een samenwerkingsverband van 26 waterschappen in Nederland waarin wordt gezocht naar mogelijkheden om energie te besparen en zelf energie te produceren. Volgens de auteurs van deze notitie leidt het initiatief van de Energiefabriek tot een reframing van de rol van waterschappen. Daarnaast leggen ze uit hoe het PPP-concept (People, Profit, Planet) kan fungeren als platform voor onderhandelingen tussen de actoren die betrokken zijn bij de Energiefabriek. Verder wordt met het PPP-concept aangetoond dat de Energiefabriek leidt tot ruimere maatschappelijke betrokkenheid, maatschappelijk ondernemen en winstvergroting.

  11. Racetrack lattices for the TRIUMF KAON factory

    International Nuclear Information System (INIS)

    Servranckx, R.V.; Wienands, U.; Craddock, M.K.; Rees, G.H.

    1989-03-01

    Separated-function racetrack lattices have been developed for the KAON Factory accelerators that have more flexibility than the old circular lattices. Straight sections with zero dispersion are provided for rf cavities and fast injection and extraction, and with controlled dispersion for H - injection and slow extraction. In addition the new lattices have fewer depolarizing resonances than the old circular lattices

  12. Factory automation for heavy electric equipment

    International Nuclear Information System (INIS)

    Rokutani, Takashi; Ninomiya, Iwao; Hatayama, Naokatsu; Kato, Hiroshi; Yano, Hideaki.

    1986-01-01

    The heightening of productivity in the factories manufacturing heavy electric equipment has been advanced so far by the rationalization of direct workings such as NC, robots and the adoption of FMS (flexible manufacturing system). However, as CAD advances, the effective utilization of these data and the expansion to future CIM (computer integrated manufacture) have become to be demanded. In the Hitachi Works of Hitachi Ltd., it was decided to advance the synthetic rationalization by adopting FA (factory automation) system. Steam turbine blades, pipings for nuclear power plants and motor coils were taken up as the objects since these are important parts, and for the purpose of the drastic heightening of QA level, the heightening of accuracy and the shortening of processes, the synchronization with field installation schedule and the creation of safe working place environment, the FA projects for these three sections were simultaneously planned. When the automation of non-mass production factories is promoted, there are the unmanned factories combining FMS lines for relatively many products and those characterized by FMC of shortening preparation time for small lot products, and this is the examples of the former. The system constitution for FA and the production management combined with it are described. The high reliability of the optical network was regarded as important. (Kako, I.)

  13. Employment and Training Problems in New Factories.

    Science.gov (United States)

    International Labour Office, Geneva (Switzerland).

    Does management in newly established factories using highly advanced technology meet special problems in recruitment and training of their workers? Are the traditional training systems supplying the skilled manpower required for running highly sophisticated plants? These were the basic questions asked when the present study was started in seven…

  14. The Mathematics of Symmetrical Factorial Designs

    Indian Academy of Sciences (India)

    The Mathematics of Symmetrical Factorial Designs. Mausumi Bose (nee Sen) obtained her MSc degree in. Statistics from the Calcutta. University and PhD degree from the Indian Statistical. Institute. She is on the faculty of the Indian. Statistical Institute. Her main field of research interest is design and analysis of experiments.

  15. A tau -- charm -- factory at Argonne

    International Nuclear Information System (INIS)

    Berger, E.; Fields, T.; Grosnick, D.; Norem, J.; Repond, J.; Schoessow, P.

    1994-01-01

    Depending on the beam energy setting, the τ -- charm -- factory will be optimized to study physics with τ leptons, with charmed mesons, or with charmonium states. This report gives a short overview of the physics of these topics. Also discussed are the detectors and the costs associated with this project

  16. Plant factories; crop transpiration and energy balance

    NARCIS (Netherlands)

    Graamans, Luuk; Dobbelsteen, van den Andy; Meinen, Esther; Stanghellini, Cecilia

    2017-01-01

    Population growth and rapid urbanisation may result in a shortage of food supplies for cities in the foreseeable future. Research on closed plant production systems, such as plant factories, has attempted to offer perspectives for robust (urban) agricultural systems. Insight into the explicit role

  17. Factorial and reduced K-means reconsidered

    NARCIS (Netherlands)

    Timmerman, Marieke E.; Ceulemans, Eva; Kiers, Henk A. L.; Vichi, Maurizio

    2010-01-01

    Factorial K-means analysis (FKM) and Reduced K-means analysis (RKM) are clustering methods that aim at simultaneously achieving a clustering of the objects and a dimension reduction of the variables. Because a comprehensive comparison between FKM and RKM is lacking in the literature so far, a

  18. Undergraduate Students' Initial Conceptions of Factorials

    Science.gov (United States)

    Lockwood, Elise; Erickson, Sarah

    2017-01-01

    Counting problems offer rich opportunities for students to engage in mathematical thinking, but they can be difficult for students to solve. In this paper, we present a study that examines student thinking about one concept within counting, factorials, which are a key aspect of many combinatorial ideas. In an effort to better understand students'…

  19. The Idea Factory: An Interactive Intergroup Exercise

    Science.gov (United States)

    Rosh, Lisa; Leach, Evan

    2011-01-01

    This article outlines the Idea Factory exercise, an interactive exercise designed to help participants examine group, individual, and organizational factors that affect intergroup conflict. Specific emphasis is placed on exploring the relationship between intra- and intergroup dynamics and identifying managerial practices that foster effective…

  20. Business plan Feed Factory Zambezi Valley, Mozambique

    NARCIS (Netherlands)

    Vernooij, A.G.; Wilschut, S.

    2015-01-01

    This business plan focuses on the establishment of a poultry feed factory, one of the essential elements of a sustainable and profitable poultry meat value chain. There is a growing demand for poultry meat in the Tete Province, and currently a large part of the consumed broilers come from other

  1. MODEL PENGELOLAAN TEACHING FACTORY SEKOLAH MENENGAH KEJURUAN

    Directory of Open Access Journals (Sweden)

    M Burhan R Wijaya

    2013-02-01

    Full Text Available This study aims to identify and develop management models Factory Teaching Vocational School through a series of tests and validation of the model with the approach of reasearch and Development. Teaching Factory Management Models at Vocational Schools is a concept that combines learning management approach learning Competency Based Training (CBT and Production Based Training (PBT in the real atmosphere so that the process of achieving competence or skill skills life skills (life skills in accordance with the standards of graduate work in the industrial world. In particular, this study aims to formulate design management model development Teaching Factory Vocational School. To achieve the research objectives above using the approach of Research and Development, through preliminary studies, design development models, testing and validation. Preliminary study phase is planned to take the flow / stage as follows: the study of literature, study / collection of field data, and a description and analysis of field findings (factual, namely: (1 the description of the characteristics of vocational school with a standard performance indicators that can be poured as the content of the development of Teaching Factory, (2 description of the characteristics and potential development group management model Tefa as an outcome groups to develop and implement management models Tefa for Vocational Schools (3 description of the characteristics of potential stakeholders to support the development and implementation TEFA management model, and (4 preparation of the management model TEFA for Vocational Schools excellence and innovative. Trial design done on a limited scale model group. Then the model was accompanied by outcome group to develop and implement a model TEFA for Vocational Schools to determine whether the model developed can be applied correctly. Data analysis in this study, the preliminary study stage, the findings or the facts about productive learning

  2. Residues leaching from 'Factory of barren ores'

    International Nuclear Information System (INIS)

    Rakhmatov, N.; Khakimov, N.; Nazarov, Kh.M.; Barotov, A.M.

    2012-01-01

    The objective of the present work is safe management of residues from Factory of Barren Ores, their reprocessing, expenditures reduction for remediation of Istiklol city former uranium tailings. For this purpose, some experiences were adopted - Factory of Barren Ores tailing use for filling up the open pit where water with uranium content 3-5 mg/l is located. Factory of Barren Ores waste are passed through heap leaching and have some amount of uranium salts dissolved in water. Thus, we propose to dissolve uranium from Factory of Barren Ores wastes with uranium bearing water flowing out from gallery and filling up the open-pit by radioactive wastes. In so doing, uranium content flowing out from gallery will increase twice, and further, passing them through apricot's shell, as a sorbent, we will clean the water against radionuclides. Residue samples with uranium content 0,015% from Factory of Barren Ores and uranium bearing waters from gallery 1 with uranium content 0,0025 g/l were used for laboratory tests. After which, a slurry was prepared by means of residue mixing with water in ratio of solid and liquid phases (S:L) - 1:2 and 9,7 ml of sulfuric acid (Ρ=1,82) was added which corresponds consumption by H 2 SO 4 176,54 kg/t. For the first test, leaching was carried out during 4 hours at ph=1,6 at room temperature. For the second test, leaching was carried out at 60 d eg C a nd ph=1,6 during 4 hours. Slurry heating and mixing was carried out by means of magnetic mixer. The basic residue leaching indicators are provided in this article.

  3. Multi-fuel multi-product operation of IGCC power plants with carbon capture and storage (CCS)

    International Nuclear Information System (INIS)

    Cormos, Ana-Maria; Dinca, Cristian; Cormos, Calin-Cristian

    2015-01-01

    This paper investigates multi-fuel multi-product operation of IGCC plants with carbon capture and storage (CCS). The investigated plant designs co-process coal with different sorts of biomass (e.g. sawdust) and solid wastes, through gasification, leading to different decarbonised energy vectors (power, hydrogen, heat, substitute natural gas etc.) simultaneous with carbon capture. Co-gasification of coal with different renewable energy sources coupled with carbon capture will pave the way towards zero emissions power plants. The energy conversions investigated in the paper were simulated using commercial process flow modelling package (ChemCAD) in order to produce mass and energy balances necessary for the proposed evaluation. As illustrative cases, hydrogen and power co-generation and Fischer–Tropsch fuel synthesis (both with carbon capture), were presented. The case studies investigated in the paper produce a flexible ratio between power and hydrogen (in the range of 400–600 MW net electricity and 0–200 MW th hydrogen considering the lower heating value) with at least 90% carbon capture rate. Special emphasis were given to fuel selection criteria for optimisation of gasification performances (fuel blending), to the selection criteria for gasification reactor in a multi-fuel multi-product operation scenario, modelling and simulation of whole process, to thermal and power integration of processes, flexibility analysis of the energy conversion processes, in-depth techno-economic and environmental assessment etc. - Highlights: • Assessment of IGCC-based energy vectors poly-generation systems with CCS. • Optimisation of gasification performances and CO 2 emissions by fuel blending. • Multi-fuel multi-product operation of gasification plants

  4. DGAT enzymes and triacylglycerol biosynthesis

    Science.gov (United States)

    Yen, Chi-Liang Eric; Stone, Scot J.; Koliwad, Suneil; Harris, Charles; Farese, Robert V.

    2008-01-01

    Triacylglycerols (triglycerides) (TGs) are the major storage molecules of metabolic energy and FAs in most living organisms. Excessive accumulation of TGs, however, is associated with human diseases, such as obesity, diabetes mellitus, and steatohepatitis. The final and the only committed step in the biosynthesis of TGs is catalyzed by acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes. The genes encoding two DGAT enzymes, DGAT1 and DGAT2, were identified in the past decade, and the use of molecular tools, including mice deficient in either enzyme, has shed light on their functions. Although DGAT enzymes are involved in TG synthesis, they have distinct protein sequences and differ in their biochemical, cellular, and physiological functions. Both enzymes may be useful as therapeutic targets for diseases. Here we review the current knowledge of DGAT enzymes, focusing on new advances since the cloning of their genes, including possible roles in human health and diseases. PMID:18757836

  5. The Spatial Organization of Glucosinolate Biosynthesis

    DEFF Research Database (Denmark)

    Nintemann, Sebastian

    cells is an open question. Likewise, it is not known how glucosinolate biosynthesis is orchestrated at the subcellular level. These open questions were addressed with several approaches in this project, with the aim of shedding light on the spatial organization of glucosinolate biosynthesis from...... between the individual classes of glucosinolates under constitutive and induced conditions and identified the source tissues of these defense compounds. Protein-protein interaction studies were carried out to investigate the subcellular organization of glucosinolate biosynthesis. We identified a family...

  6. Flow-based approach for holistic factory engineering and design

    OpenAIRE

    Constantinescu, C.; Westkämper, E.

    2010-01-01

    The engineering of future factories requires digital tools along life cycle phases from investment planning to ramp-up. Manufacturers need scientific-based integrated highly dynamic data management systems for the participative and integrated factory planning. The paper presents a new approach for the continuously integrated product design, factory and process planning, through a service-oriented architecture for the implementation of digital factory tools. A first prototype of the digital fa...

  7. An Interactive Simulation Tool for Production Planning in Bacon Factories

    DEFF Research Database (Denmark)

    Nielsen, Jens Frederik Dalsgaard; Nielsen, Kirsten Mølgaard

    1994-01-01

    The paper describes an interactive simulation tool for production planning in bacon factories. The main aim of the tool is to make it possible to combine the production plans of all parts of the factory......The paper describes an interactive simulation tool for production planning in bacon factories. The main aim of the tool is to make it possible to combine the production plans of all parts of the factory...

  8. Microbial Cell Factories for the Production of Terpenoid Flavor and Fragrance Compounds.

    Science.gov (United States)

    Schempp, Florence M; Drummond, Laura; Buchhaupt, Markus; Schrader, Jens

    2018-03-14

    Terpenoid flavor and fragrance compounds are of high interest to the aroma industry. Microbial production offers an alternative sustainable access to the desired terpenoids independent of natural sources. Genetically engineered microorganisms can be used to synthesize terpenoids from cheap and renewable resources. Due to its modular architecture, terpenoid biosynthesis is especially well suited for the microbial cell factory concept: a platform host engineered for a high flux toward the central C 5 prenyl diphosphate precursors enables the production of a broad range of target terpenoids just by varying the pathway modules converting the C 5 intermediates to the product of interest. In this review typical terpenoid flavor and fragrance compounds marketed or under development by biotech and aroma companies are given, and the specificities of the aroma market are discussed. The main part of this work focuses on key strategies and recent advances to engineer microbes to become efficient terpenoid producers.

  9. The Virtual Factory Teaching System (VFTS): Project Review and Results.

    Science.gov (United States)

    Kazlauskas, E. J.; Boyd, E. F., III; Dessouky, M. M.

    This paper presents a review of the Virtual Factory Teaching (VFTS) project, a Web-based, multimedia collaborative learning network. The system allows students, working alone or in teams, to build factories, forecast demand for products, plan production, establish release rules for new work into the factory, and set scheduling rules for…

  10. e sup + e sup - Factories: PEP-II, KEKB, DAPHINE

    CERN Document Server

    Guiducci, S

    2001-01-01

    In 1999 two B-factories, PEP-II and KEK, and a PHI-factory, DAPHINE, started their physics experiments. A status report of the three factories is presented. A description of the interaction regions, strongly influenced by the detector requirements, and of the machine background in the detectors is presented.

  11. The Physics of the B Factories

    Energy Technology Data Exchange (ETDEWEB)

    Bevan, A.J. [Queen Mary Univ., London (United Kingdom); Golob, B. [Ljubljana Univ. (Slovenia). Faculty of Mathematics and Physics; J. Stefan Institute, Ljubljana (Slovenia); Mannel, T. [Siegen Univ. (Germany). Theoretische Physik 1; Collaboration: BABAR Collaboration; Belle Collaboration; and others

    2014-11-15

    The inspiration for this book came from Fran@cois le Diberder. During his term as spokesperson for BABAR he laid down a vision for the two B Factory detector collaborations, BABAR and Belle, to work together on a book that would describe the methodologies used and physics results obtained by those experiments. A key ideal emphasized from the outset was that this book should be written from a pedagogical perspective; it should be of interest to the student and expert alike. This vision was presented during a BABAR collaboration meeting on the island of Elba in May 2008 and a follow up Belle collaboration meeting at KEK, with visiting colleagues from the BABAR collaboration, and was embraced by the community. A number of workshops involving people from the theoretical community as well as the two collaborations were held on four continents over the following years. The resulting book, ''The Physics of the B Factories'', is a testament to the way that this concept captured the zeitgeist on both sides of the Pacific Ocean. This book is divided into three parts, the first of which provides a brief description of the B Factories, including a short (though not exhaustive) historical perspective, as well as descriptions of the detectors, ancillary data acquisition systems and data (re)processing systems that were built by the two detector collaborations in the late 1990's. The second part of the book discusses tools and methods that are frequently used when analyzing the data collected. These range from details of low level reconstruction algorithms and abstract summaries of statistical methods to high level prescriptions used when evaluating systematic uncertainties on measurements of observables. The third part of the book is devoted to physics results. This includes sufficient theoretical discussion in order for the reader to understand the context of the work being described. We are indebted to our colleagues from the theoretical community who

  12. The Physics of the B Factories

    International Nuclear Information System (INIS)

    Bevan, A.J.; Golob, B.; Mannel, T.

    2014-01-01

    The inspiration for this book came from Fran@cois le Diberder. During his term as spokesperson for BABAR he laid down a vision for the two B Factory detector collaborations, BABAR and Belle, to work together on a book that would describe the methodologies used and physics results obtained by those experiments. A key ideal emphasized from the outset was that this book should be written from a pedagogical perspective; it should be of interest to the student and expert alike. This vision was presented during a BABAR collaboration meeting on the island of Elba in May 2008 and a follow up Belle collaboration meeting at KEK, with visiting colleagues from the BABAR collaboration, and was embraced by the community. A number of workshops involving people from the theoretical community as well as the two collaborations were held on four continents over the following years. The resulting book, ''The Physics of the B Factories'', is a testament to the way that this concept captured the zeitgeist on both sides of the Pacific Ocean. This book is divided into three parts, the first of which provides a brief description of the B Factories, including a short (though not exhaustive) historical perspective, as well as descriptions of the detectors, ancillary data acquisition systems and data (re)processing systems that were built by the two detector collaborations in the late 1990's. The second part of the book discusses tools and methods that are frequently used when analyzing the data collected. These range from details of low level reconstruction algorithms and abstract summaries of statistical methods to high level prescriptions used when evaluating systematic uncertainties on measurements of observables. The third part of the book is devoted to physics results. This includes sufficient theoretical discussion in order for the reader to understand the context of the work being described. We are indebted to our colleagues from the theoretical community who have helped us achieve

  13. Portable Material Culture and Death Factory Auschwitz

    Directory of Open Access Journals (Sweden)

    Adrian T. Myers

    2007-11-01

    Full Text Available Like any other factory, the death factory of Auschwitz consumed primary materials and produced secondary products. Unique to Auschwitz, though, is that the primary material consumed was human life; not just the life of the breathing human body, but also the material possessions associated with that life. The detritus of this most efficient genocide – clothing, jewellery, food, corpses – was appropriated and put to new uses by the SS and the prisoners. Others have recognised the various postwar material cultural outcomes of the camp: the writing, the film, the theatre, the art, the tourism. This article, however, demonstrates that the material culture of Auschwitz is not a phenomenon exclusive to the postwar era. It focuses on the fact that inside the camp during the war, despite the landscape of death and deprivation, intimate interaction between humans and material culture continued.

  14. JINR tau-charm factory design study

    International Nuclear Information System (INIS)

    Perel'shtejn, E.; Aleksandrov, V.; Antropov, V.

    1993-01-01

    The review on tau-charm factory in JINR (Dubna) is presented. The structure scheme of tau-charm factory is described. The problems on injection complex are discussed: the composition, the working regime and parameters. The magnetic lattice of a booster is described. A versatile magnet lattice is used in tau-charm collider. It can realize both conventional flat beam scheme and monochromatization scheme. The results of chromaticity correction in high emittance lattice are presented. The list of parameters of tau-charm collider is given. The technical proposal of magnetic elements of booster and collider and their power supplies is made, as well as RF power supply in collider and vacuum system in its periodic cell. 12 refs.; 12 figs.; 3 tabs

  15. B factory rf system design issues

    International Nuclear Information System (INIS)

    Zisman, M.S.

    1992-06-01

    We discuss the issues of relevance to the design of a B factory RF system. First, the general parameter regime is outlined, and the reasons behind certain commonly made choices are indicated. This regime involves high beam currents, and many relatively short bunches. Next, the physics difficulties associated with coupled-bunch instabilities are described briefly. We then describe in general terms the alternative approaches taken by various B factory designers, the motivation for these choices, and the technical issues raised by them. Technical solutions have been proposed for both the room-temperature and the superconducting RF scenarios, and considerable R ampersand D is being carried out worldwide to confirm and optimize these solutions

  16. Physics at e+e- factories

    International Nuclear Information System (INIS)

    Lueth, V.; MacFarlane, D.B.

    1991-02-01

    Feasible designs are well advanced for high-luminosity e + e - storage rings which produce B 0 bar B 0 pairs either at rest or, in what appears to be a more promising option, boosted in the detector frame. Facilities which could provide samples of 30--100 fb -1 per year on the Υ(4S) will be proposed in early 1991. Here we examine the principal physics goal of such B Factories, namely CP violation in the b system. Methods in a variety of channels, estimated event samples, and detector requirements are all considered. We conclude that the physics argument for an e + e - B Factory is well documented, and compelling. 50 refs., 22 figs., 10 tabs

  17. B factory RF system design issues

    International Nuclear Information System (INIS)

    Zisman, M.S.

    1992-01-01

    We discuss the issues of relevance to the design of a B factory RF system. First, the general parameter regime is outlined, and the reasons behind certain commonly made choices are indicated. This regime involves high beam currents, and many relatively short bunches. Next, the physics difficulties associated with coupled-bunch instabilities are described briefly. We then describe in general terms the alternative approaches taken by various B factory designers, the motivation for these choices, and the technical issues raised by them. Technical solutions have been proposed for both the room-temperature and the superconducting RF scenarios, and considerable R ampersand D is being carried out worldwide to confirm and optimize these solutions

  18. Neutrino Factory Targets and the MICE Beam

    International Nuclear Information System (INIS)

    Walaron, Kenneth A.

    2007-01-01

    The future of particle physics in the next 20 years must include detailed study of neutrinos. The first proof of physics beyond the Standard Model of particle physics is evident in results from recent neutrino experiements which imply that neutrinos have mass and flavour mixing. The Neutrino Factory is the leading contender to measure precisely the neutrino mixing parameters to probe beyond the Standard Model physics.

  19. Review of proposed kaon factory facilities

    International Nuclear Information System (INIS)

    Macek, R.J.

    1985-01-01

    A number of proton accelerator facilities, popularly called ''Kaon Factories,'' have been proposed to extend the intensity frontier from about 1 GeV to higher energies in the range of 15 to 45 GeV. Seven proposed facilities - LAMPF II, TRIUMF II, SIN II, AGS II, KEK, MUNICH, and KYOTO - are reviewed with emphasis on capabilities of the experimental facilities. Costs and the choice of energy and current are also discussed. 7 refs., 29 figs., 7 tabs

  20. Design studies for the Positron Factory

    International Nuclear Information System (INIS)

    Okada, S.; Sunaga, H.; Kaneko, H.; Masuno, S.; Kawasuso, A.; Sakai, T.; Takizawa, H.; Yotsumoto, K.; Honda, Y.; Tagawa, S.

    1996-01-01

    In the design study for the Positron Factory, a feasibility of simultaneous extraction of multi-channel monoenergetic positron beams, which had been proposed at the previous conference (Linac 94), was demonstrated by an experiment using an electron linac. On the basis of the experimental result, an efficient moderator structure, which is composed of honeycomb-like assembled moderator foils and reflectors, is proposed. (author)

  1. Muon front end for the neutrino factory

    Directory of Open Access Journals (Sweden)

    C. T. Rogers

    2013-04-01

    Full Text Available In the neutrino factory, muons are produced by firing high-energy protons onto a target to produce pions. The pions decay to muons and pass through a capture channel known as the muon front end, before acceleration to 12.6 GeV. The muon front end comprises a variable frequency rf system for longitudinal capture and an ionization cooling channel. In this paper we detail recent improvements in the design of the muon front end.

  2. Muon front end for the neutrino factory

    CERN Document Server

    Rogers, C T; Prior, G; Gilardoni, S; Neuffer, D; Snopok, P; Alekou, A; Pasternak, J

    2013-01-01

    In the neutrino factory, muons are produced by firing high-energy protons onto a target to produce pions. The pions decay to muons and pass through a capture channel known as the muon front end, before acceleration to 12.6 GeV. The muon front end comprises a variable frequency rf system for longitudinal capture and an ionization cooling channel. In this paper we detail recent improvements in the design of the muon front end.

  3. LAMPF: the meson factory. A LASL monograph

    Energy Technology Data Exchange (ETDEWEB)

    Allred, J.C.

    1977-08-01

    A general and simplified introduction to the entire concept of LAMPF is given in terms of its experimental capabilities. Parts of the current experimental program are used as illustrative examples. Topics discussed include: (1) the evolution of the meson factory; (2) accelerator construction; (3) strong focusing; (4) accelerator innovations at LAMPF; (5) photons and pions; (6) muons as nuclear probes; (7) nuclear chemistry; (8) radiobiology and medical applications; (9) radioisotope production; (10) materials testing; and (11) LAMPF management and users group. (PMA)

  4. Collective issues related to B-factories

    International Nuclear Information System (INIS)

    Pestrikov, D.V.

    1993-02-01

    This report reviews the limitations on the performance of the planned B- and Φ-factories due to the collective interactions of stored bunches. Together with the traditional revision of the limitations due to the single- and multi-bunch interaction with surrounding electrodes, we briefly discuss in this report the limitations on the performance due to collective beam-beam instabilities of colliding beams and instabilities due to the collective interaction of beams with the ions. (author)

  5. LAMPF: the meson factory. A LASL monograph

    International Nuclear Information System (INIS)

    Allred, J.C.

    1977-08-01

    A general and simplified introduction to the entire concept of LAMPF is given in terms of its experimental capabilities. Parts of the current experimental program are used as illustrative examples. Topics discussed include: (1) the evolution of the meson factory; (2) accelerator construction; (3) strong focusing; (4) accelerator innovations at LAMPF; (5) photons and pions; (6) muons as nuclear probes; (7) nuclear chemistry; (8) radiobiology and medical applications; (9) radioisotope production; (10) materials testing; and (11) LAMPF management and users group

  6. The Factory of the Future, Group Exhibition

    OpenAIRE

    Dean, Lionel T.

    2016-01-01

    3D Printing, The factory of the future, Lieu du Design (centre for Design), Paris This exhibition dedicated entirely to 3D printing technology was billed as “the first in France wholly devoted to exploring the interdisciplinary and multifaceted topic of 3D printing technology and its undeniable influence on everything from industry, to economics, to creative and social issues, demonstrated to the public through achievements in the fields of 3D design, 3D printed architecture, 3D printed fa...

  7. Cell factories for a sustainable world

    DEFF Research Database (Denmark)

    Kindtler, Jens William

    2016-01-01

    The Novo Nordisk Foundation Center for Biosustainability (CFB) is a university research center under the Technical University of Denmark within the field of design, engineering and construction of superior cell factories for the production of biopharmaceuticals, anti-infective compounds, industrial......-spectrum inhibitors against multi-drug resistant (MDR) Gram-negative bacterial pathogens using co-Adaptive Laboratory Evolution, 3. Design and engineering of E. coli and Saccharomyces cerevisiae for biobased production of various classes of chemicals. CFB has 230 employees....

  8. A biophysical model for transcription factories

    International Nuclear Information System (INIS)

    Canals-Hamann, Ana Z; Neves, Ricardo Pires das; Reittie, Joyce E; Iñiguez, Carlos; Soneji, Shamit; Enver, Tariq; Buckle, Veronica J; Iborra, Francisco J

    2013-01-01

    Transcription factories are nuclear domains where gene transcription takes place although the molecular basis for their formation and maintenance are unknown. In this study, we explored how the properties of chromatin as a polymer may contribute to the structure of transcription factories. We found that transcriptional active chromatin contains modifications like histone H4 acetylated at Lysine 16 (H4K16ac). Single fibre analysis showed that this modification spans the entire body of the gene. Furthermore, H4K16ac genes cluster in regions up to 500 Kb alternating active and inactive chromatin. The introduction of H4K16ac in chromatin induces stiffness in the chromatin fibre. The result of this change in flexibility is that chromatin could behave like a multi-block copolymer with repetitions of stiff-flexible (active-inactive chromatin) components. Copolymers with such structure self-organize through spontaneous phase separation into microdomains. Consistent with such model H4K16ac chromatin form foci that associates with nascent transcripts. We propose that transcription factories are the result of the spontaneous concentration of H4K16ac chromatin that are in proximity, mainly in cis

  9. A tau-charm-factory at Argonne

    International Nuclear Information System (INIS)

    Norem, J.; Repond, J.

    1994-01-01

    In this paper we explore the possibility of building a tau-charm-factory at the Argonne National Laboratory. A tau-charm-factory is an e + e - collider with a center-of-mass energy between 3.0 GeV and 5.0 GeV and a luminosity of at least 1 x 10 33 cm -2 s -1 . Once operational, the facility will produce large samples of τ pairs, charm mesons, and charmonium with either negligible or well understood backgrounds. This will lead to high precision measurements in the second generation quark and the third generation lepton sectors that cannot be done at other facilities. Basic physical properties and processes, such as the tau neutrino mass, rare tau decays, charm decay constants, rare charm meson decays, neutral D 0 -- meson mixing, and many more will be studied with unique precision. An initial design of the collider including the injector system is described. The design shows that a luminosity of at least 1 x 10 33 cm -2 s -1 can be achieved over the entire center-of-mass energy range of the factory

  10. Ultrastructural Characterization of Zika Virus Replication Factories

    Directory of Open Access Journals (Sweden)

    Mirko Cortese

    2017-02-01

    Full Text Available Summary: A global concern has emerged with the pandemic spread of Zika virus (ZIKV infections that can cause severe neurological symptoms in adults and newborns. ZIKV is a positive-strand RNA virus replicating in virus-induced membranous replication factories (RFs. Here we used various imaging techniques to investigate the ultrastructural details of ZIKV RFs and their relationship with host cell organelles. Analyses of human hepatic cells and neural progenitor cells infected with ZIKV revealed endoplasmic reticulum (ER membrane invaginations containing pore-like openings toward the cytosol, reminiscent to RFs in Dengue virus-infected cells. Both the MR766 African strain and the H/PF/2013 Asian strain, the latter linked to neurological diseases, induce RFs of similar architecture. Importantly, ZIKV infection causes a drastic reorganization of microtubules and intermediate filaments forming cage-like structures surrounding the viral RF. Consistently, ZIKV replication is suppressed by cytoskeleton-targeting drugs. Thus, ZIKV RFs are tightly linked to rearrangements of the host cell cytoskeleton. : Cortese et al. show that ZIKV infection in both human hepatoma and neuronal progenitor cells induces drastic structural modification of the cellular architecture. Microtubules and intermediate filaments surround the viral replication factory composed of vesicles corresponding to ER membrane invagination toward the ER lumen. Importantly, alteration of microtubule flexibility impairs ZIKV replication. Keywords: Zika virus, flavivirus, human neural progenitor cells, replication factories, replication organelles, microtubules, intermediate filaments, electron microscopy, electron tomography, live-cell imaging

  11. Engineering Robustness of Microbial Cell Factories.

    Science.gov (United States)

    Gong, Zhiwei; Nielsen, Jens; Zhou, Yongjin J

    2017-10-01

    Metabolic engineering and synthetic biology offer great prospects in developing microbial cell factories capable of converting renewable feedstocks into fuels, chemicals, food ingredients, and pharmaceuticals. However, prohibitively low production rate and mass concentration remain the major hurdles in industrial processes even though the biosynthetic pathways are comprehensively optimized. These limitations are caused by a variety of factors unamenable for host cell survival, such as harsh industrial conditions, fermentation inhibitors from biomass hydrolysates, and toxic compounds including metabolic intermediates and valuable target products. Therefore, engineered microbes with robust phenotypes is essential for achieving higher yield and productivity. In this review, the recent advances in engineering robustness and tolerance of cell factories is described to cope with these issues and briefly introduce novel strategies with great potential to enhance the robustness of cell factories, including metabolic pathway balancing, transporter engineering, and adaptive laboratory evolution. This review also highlights the integration of advanced systems and synthetic biology principles toward engineering the harmony of overall cell function, more than the specific pathways or enzymes. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Neutrinos: from the Workshop to the Factory

    CERN Multimedia

    2001-01-01

    Over the next 5 years much work will be done to reach a theoretical and practical description of a neutrino factory. How could this project turn out to be an interesting future option for CERN? Neutrino beams travelling from CERN to the Canary Islands? And to the Svalbard archipelago in Norway? Or even to the Pyhaesalmi Mine in Finland? Why neutrinos? And why so far? The answers provide one of CERN's next challenging options: the construction of a high-energy muon storage ring to provide neutrino beams. This project, nicknamed 'neutrino factory', now figures in CERN's middle term plan as a recognized and supported research and development project. International collaborations, with other European laboratories and also with America and Japan, are now being set up. Long baseline locations for neutrino oscillations studies at a CERN based neutrino factory. Early in its history, LEP established that there exist just three kinds of light neutrinos, those associated with the electron, muon, and tau leptons. For a...

  13. An asymmetric B factory based on PEP

    Energy Technology Data Exchange (ETDEWEB)

    1991-02-01

    In this report we describe a design for a high-luminosity Asymmetric B Factory to be built in the PEP tunnel on the SLAC site. This proposal, a collaborative effort SLAC, LBL, and LLNL, is the culmination of more than two years of effort aimed at the design and construction of an asymmetric e{sup +}e{sup {minus}} collider capable of achieving a luminosity of L = 3 {times} 10{sup 33} cm{sup {minus}2} s{sup {minus}1}. The configuration adopted utilizes two storage rings, and electron ring operating at 9 GeV and a positron ring at 3.1 GeV, each with a circumference of 2200 m. The high-energy ring is an upgrade of the PEP storage ring at SLAC; all PEP magnets and most power supplies will be reused. The upgrade consists primarily of replacing the PEP vacuum chamber and RF system with newly designed versions optimized for the high-current environment of the B Factory. The low-energy ring will be newly constructed and will be situated atop the high-energy ring in the PEP tunnel. Utilities already installed in the PEP tunnel are largely sufficient to operate the two B Factory storage rings.

  14. An asymmetric B factory based on PEP

    International Nuclear Information System (INIS)

    1991-02-01

    In this report we describe a design for a high-luminosity Asymmetric B Factory to be built in the PEP tunnel on the SLAC site. This proposal, a collaborative effort SLAC, LBL, and LLNL, is the culmination of more than two years of effort aimed at the design and construction of an asymmetric e + e - collider capable of achieving a luminosity of L = 3 x 10 33 cm -2 s -1 . The configuration adopted utilizes two storage rings, and electron ring operating at 9 GeV and a positron ring at 3.1 GeV, each with a circumference of 2200 m. The high-energy ring is an upgrade of the PEP storage ring at SLAC; all PEP magnets and most power supplies will be reused. The upgrade consists primarily of replacing the PEP vacuum chamber and RF system with newly designed versions optimized for the high-current environment of the B Factory. The low-energy ring will be newly constructed and will be situated atop the high-energy ring in the PEP tunnel. Utilities already installed in the PEP tunnel are largely sufficient to operate the two B Factory storage rings

  15. Factorial complexity and Morally Debatable Behaviors

    Directory of Open Access Journals (Sweden)

    Grimaldo Muchotrigo, Mirian P.

    2011-12-01

    Full Text Available Currently, from the scientific and professional practice point of view, comes out the necessity to know more about moral permissiveness, as it seems to be an increase in “moral relativism”.. Because it, it this is important to have tools to collect valid and reliable information about moral in social situations defined as social and personal behavior issue. This paper presents a technical note of The Morally Debatable Behaviors Scale (MDBS from Harding & Phillips (1986, which was developed in USA and mainly focused on young people and adults. This technical note makes direct reference to a recent Latin American study (Merino & Grimaldo, 2010; this article focuses on the internal structure and the problems associated with evidences of factorial complexity among items of the MDBS. This means that the interpretation of scores is not factorially simple and could not be achieved by a conceptual distinction between the latent constructs applied to the study sample.. The results in the previous study of the factorial complexity leads the researcher to decide whether an instrument for measuring this aspect may contain a reasonable amount of complexity that is consistent with what is in reality, or look for the unidimensional and simple structure.

  16. Monoterpene biosynthesis potential of plant subcellular compartments

    NARCIS (Netherlands)

    Dong, L.; Jongedijk, E.J.; Bouwmeester, H.J.; Krol, van der A.R.

    2016-01-01

    Subcellular monoterpene biosynthesis capacity based on local geranyl diphosphate (GDP) availability or locally boosted GDP production was determined for plastids, cytosol and mitochondria. A geraniol synthase (GES) was targeted to plastids, cytosol, or mitochondria. Transient expression in Nicotiana

  17. Method for determining heterologous biosynthesis pathways

    KAUST Repository

    Gao, Xin; Kuwahara, Hiroyuki; Alazmi, Meshari Saud; Cui, Xuefeng

    2017-01-01

    suitable pathways for the endogenous metabolism of a host organism because the efficacy of heterologous biosynthesis is affected by competing endogenous pathways. The present invention is called MRE (Metabolic Route Explorer), and it was conceived

  18. Biosynthesis and engineering of kaempferol in Saccharomyces cerevisiae.

    Science.gov (United States)

    Duan, Lijin; Ding, Wentao; Liu, Xiaonan; Cheng, Xiaozhi; Cai, Jing; Hua, Erbing; Jiang, Huifeng

    2017-09-26

    Kaempferol is a flavonol with broad bioactivity of anti-oxidant, anti-cancer, anti-diabetic, anti-microbial, cardio-protective and anti-asthma. Microbial synthesis of kaempferol is a promising strategy because of the low content in primary plant source. In this study, the biosynthesis pathway of kaempferol was constructed in the budding yeast Saccharomyces cerevisiae to produce kaempferol de novo, and several biological measures were taken for high production. Firstly, a high efficient flavonol synthases (FLS) from Populus deltoides was introduced into the biosynthetic pathway of kaempferol. Secondly, a S. cerevisiae recombinant was constructed for de novo synthesis of kaempferol, which generated about 6.97 mg/L kaempferol from glucose. To further promote kaempferol production, the acetyl-CoA biosynthetic pathway was overexpressed and p-coumarate was supplied as substrate, which improved kaempferol titer by about 23 and 120%, respectively. Finally, a fed-batch process was developed for better kaempferol fermentation performance, and the production reached 66.29 mg/L in 40 h. The titer of kaempferol in our engineered yeast is 2.5 times of the highest reported titer. Our study provides a possible strategy to produce kaempferol using microbial cell factory.

  19. Economic and greenhouse gas emission analysis of bioenergy production using multi-product crops-case studies for the Netherlands and Poland

    International Nuclear Information System (INIS)

    Dornburg, V.; Termeer, G.; Faaij, A.P.C.

    2005-01-01

    In the face of climate change that may result from greenhouse gas (GHG) emissions, the scarcity of agricultural land and limited competitiveness of biomass energy on the market, it is desirable to increase the performance of bioenergy systems. Multi-product crops, i.e. using a crop partially for energy and partially for material purposes can possibly create additional incomes as well as additional GHG emission reductions. In this study, the performance of several multi-product crop systems is compared to energy crop systems, focused on the costs of primary biomass fuel costs and GHG emission reductions per hectare of biomass production. The sensitivity of the results is studied by means of a Monte-Carlo analysis. The multi-product crops studied are wheat, hemp and poplar in the Netherlands and Poland. GHG emission reductions of these multi-product crop systems are found to be between 0.2 and 2.4 Mg CO 2eq /(ha yr) in Poland and 0.9 and 7.8 Mg CO 2eq /(ha yr) in the Netherlands, while primary biomass fuel costs range from -4.1 to -1.7 EURO /GJ in the Netherlands and from 0.1 to 9.8 EURO /GJ in Poland. Results show that the economic attractiveness of multi-product crops depends strongly on material market prices, crop production costs and crop yields. Net annual GHG emission reductions per hectare are influenced strongly by the specific GHG emission reduction of material use, reference energy systems and GHG emissions of crop production. Multi-product use of crops can significantly decrease primary biomass fuel costs. However, this does not apply in general, but depends on the kind of crops and material uses. For the examples analysed here, net annual GHG emission reductions per hectare are not lowered by multi-product use of crops. Consequently, multi-product crops are not for granted an option to increase the performance of bioenergy systems. Further research on the feasibility of large-scale multi-product crop systems and their impact on land and material markets

  20. Cellulose biosynthesis in higher plants

    Directory of Open Access Journals (Sweden)

    Krystyna Kudlicka

    2014-01-01

    Full Text Available Knowledge of the control and regulation of cellulose synthesis is fundamental to an understanding of plant development since cellulose is the primary structural component of plant cell walls. In vivo, the polymerization step requires a coordinated transport of substrates across membranes and relies on delicate orientations of the membrane-associated synthase complexes. Little is known about the properties of the enzyme complexes, and many questions about the biosynthesis of cell wall components at the cell surface still remain unanswered. Attempts to purify cellulose synthase from higher plants have not been successful because of the liability of enzymes upon isolation and lack of reliable in vitro assays. Membrane preparations from higher plant cells incorporate UDP-glucose into a glucan polymer, but this invariably turns out to be predominantly β -1,3-linked rather than β -1,4-linked glucans. Various hypotheses have been advanced to explain this phenomenon. One idea is that callose and cellulose-synthase systems are the same, but cell disruption activates callose synthesis preferentially. A second concept suggests that a regulatory protein as a part of the cellulose-synthase complex is rapidly degraded upon cell disruption. With new methods of enzyme isolation and analysis of the in vitro product, recent advances have been made in the isolation of an active synthase from the plasma membrane whereby cellulose synthase was separated from callose synthase.

  1. Confirmatory factorial analysis of TEOSQp / Análise factorial confirmatória do TEOSQp

    Directory of Open Access Journals (Sweden)

    Helder M. Fernandes

    2010-01-01

    Full Text Available The present research assessed the reliability, factorial validity and measurement invariance (by gender of the Portuguese version of TEOSQ –Task and Ego Orientation in Sport Questionnaire (Fonseca & Biddle, 2001. Data were collected from 1010 physical education students with a mean age of 15.42 ( SD=1.91. Factorial and invariance measurements were tested via confirmatory factorial analysis. Results supported internal consistency for the two proposed subscales (task and ego. Based on modification indices and theoretical justification the TEOSQ p was reduced to 12 items with better goodness-of-fit indices for the oblique model. The results of gender invariance did not provide full empirical support to the multi-group equivalence assumption, being suggested that TEOSQ p does not measure in the same way goal orientations for boys (orthogonal model and girls (oblique model. In light of these results, conceptual, empirical and practical issues were discussed.

  2. In-Factory Learning - Qualification For The Factory Of The Future

    Science.gov (United States)

    Quint, Fabian; Mura, Katharina; Gorecky, Dominic

    2015-07-01

    The Industry 4.0 vision anticipates that internet technologies will find their way into future factories replacing traditional components by dynamic and intelligent cyber-physical systems (CPS) that combine the physical objects with their digital representation. Reducing the gap between the real and digital world makes the factory environment more flexible, more adaptive, but also more complex for the human workers. Future workers require interdisciplinary competencies from engineering, information technology, and computer science in order to understand and manage the diverse interrelations between physical objects and their digital counterpart. This paper proposes a mixed-reality based learning environment, which combines physical objects and visualisation of digital content via Augmented Reality. It uses reality-based interaction in order to make the dynamic interrelations between real and digital factory visible and tangible. We argue that our learning system does not work as a stand-alone solution, but should fit into existing academic and advanced training curricula.

  3. A comparison of HK-CONWIP and BK-CONWIP control strategies in a multi-product manufacturing system

    Directory of Open Access Journals (Sweden)

    Chukwunonyelum Emmanuel Onyeocha

    2015-12-01

    Full Text Available This paper evaluates the performance of the Hybrid Kanban Constant Work-In-Process control strategy and Basestock Kanban Constant Work-In-Process control strategy operating Shared Kanban Allocation Policy (S-KAP and Dedicated Kanban Allocation Policy (D-KAP in a multi-product serial flow line. We explored the effect of an increase of product types on the WIP inventory in the system. A simulation-based optimisation technique was used in determining the optimal settings for the strategies. The strategies were compared via pairwise comparison technique and Nelson’s ranking and selection procedure. S-KAP responds quicker to demand than D-KAP. BK-CONWIP outperforms HK-CONWIP in a serial manufacturing system. It was shown that an increase in the number of product-type increases the number of PAC and WIP inventory.

  4. Stochastic multi-period multi-product multi-objective Aggregate Production Planning model in multi-echelon supply chain

    Directory of Open Access Journals (Sweden)

    Kaveh Khalili-Damghani

    2017-07-01

    Full Text Available In this paper a multi-period multi-product multi-objective aggregate production planning (APP model is proposed for an uncertain multi-echelon supply chain considering financial risk, customer satisfaction, and human resource training. Three conflictive objective functions and several sets of real constraints are considered concurrently in the proposed APP model. Some parameters of the proposed model are assumed to be uncertain and handled through a two-stage stochastic programming (TSSP approach. The proposed TSSP is solved using three multi-objective solution procedures, i.e., the goal attainment technique, the modified ε-constraint method, and STEM method. The whole procedure is applied in an automotive resin and oil supply chain as a real case study wherein the efficacy and applicability of the proposed approaches are illustrated in comparison with existing experimental production planning method.

  5. The Tau-Charm Factory in the ERA of B-Factories and CESR

    International Nuclear Information System (INIS)

    Beers, L.V.; Perl, M.L.

    1994-10-01

    This paper is a collection of presentations made at a conference on tau-charm factories, held at the Stanford Linear Accelerator Center and Stanford University on August 15-16, 1994. The papers presented summarize the physics which can be learned from such a facility, the advantages it would present over planned B-factories and large centers such as CESR, and the types of decay modes which could be observed. More detailed studies of tau physics are opened up, as well as charmonium and charmed systems. Seperate presentations to the proceedings are indexed individually into the database

  6. Diamond Growth in the Subduction Factory

    Science.gov (United States)

    Bureau, H.; Frost, D. J.; Bolfan-Casanova, N.; Leroy, C.; Estève, I.

    2014-12-01

    Natural diamonds are fabulous probes of the deep Earth Interior. They are the evidence of the deep storage of volatile elements, carbon at first, but also hydrogen and chlorine trapped as hydrous fluids in inclusions. The study of diamond growth processes in the lithosphere and mantle helps for our understanding of volatile elements cycling between deep reservoirs. We know now that inclusion-bearing diamonds similar to diamonds found in nature (i.e. polycrystalline, fibrous and coated diamonds) can grow in hydrous fluids or melts (Bureau et al., GCA 77, 202-214, 2012). Therefore, we propose that the best environment to promote such diamonds is the subduction factory, where highly hydrous fluids or melts are present. When oceanic plates are subducted in the lithosphere, they carry an oceanic crust soaked with seawater. While the slabs are traveling en route to the mantle, dehydration processes generate saline fluids highly concentrated in NaCl. In the present study we have experimentally shown that diamonds can grow from the saline fluids (up to 30 g/l NaCl in water) generated in subducted slabs. We have performed multi-anvil press experiments at 6-7 GPa and from 1300 to 1400°C during 6:00 hours to 30:00 hours. We observed large areas of new diamond grown in epitaxy on pure diamond seeds in salty hydrous carbonated melts, forming coated gems. The new rims are containing multi-component primary inclusions. Detailed characterizations of the diamonds and their inclusions have been performed and will be presented. These experimental results suggest that multi-component salty fluids of supercritical nature migrate with the slabs, down to the deep mantle. Such fluids may insure the first stage of the deep Earth's volatiles cycling (C, H, halogen elements) en route to the transition zone and the lower mantle. We suggest that the subduction factory may also be a diamond factory.

  7. Recent developments at the TRIUMF meson factory

    International Nuclear Information System (INIS)

    Craddock, M.K.

    1976-10-01

    The TRIUMF meson factory, which is based on a 6-sector isochronous cyclotron accelerating H - ions to 520 MeV, has been operating since December 1974. Two proton beams are extracted simultaneously to feed the two experimental areas. Characteristics of the beams and beam lines are given. Work is also proceeding on (i) additional beam lines, (ii) a 180 kW beam dump and thermal neutron source, (iii) a medium resolution proton spectrometer, and (iv) adding third harmonic flat-topping to the RF to permit separation of the internal orbits and reduction of the energy spread of the extracted beam to 0.1 MeV. (author)

  8. RI beam factory project at RIKEN

    CERN Document Server

    Motobayashi, T

    2003-01-01

    Construction of the RI beam factory project in the first phase has started. The aim of the project is to provide intense radio-isotopes (RI) beams at energies of several hundred MeV/nucleon in a wide range of atomic masses. These beams will be produced by the projectile fragmentation of primary beams accelerated by a cascade of the existing ring cyclotron and a series of new ring cyclotrons. Improvements of the existing facility made for the new cyclotron complex have extended the energy range of available beams, which already opened new domains of study.

  9. The physics case of the Neutrino Factory

    Energy Technology Data Exchange (ETDEWEB)

    Gomez-Cadenas, J J [IFIC, CSIC-UV, Valencia (Spain)], E-mail: gomez@ific.uv.es

    2008-11-01

    I discuss the physics case of the standard Neutrino Factory facility coupled to an iron detector to exploit the so-called 'Golden-Channel'. The performance of the facility is impressive, although it is not free from degeneracies arising from a combination of physics and instrumental limitations. Nevertheless, one could explore at great depth the parameter of the leptonic mixing matrix as well as the mass hierarchy. Best performance is obtained with two baselines (one of them very long) and an improved magnetic detector with low energy detection threshold.

  10. Advanced manufacturing: optimising the factories of tomorrow

    International Nuclear Information System (INIS)

    Philippon, Patrick

    2013-01-01

    Faced with competition Patrick Philippon - Les Defis du CEA no.179 - April 2013 from the emerging countries, the competitiveness of the industrialised nations depends on the ability of their industries to innovate. This strategy necessarily entails the reorganisation and optimisation of the production systems. This is the whole challenge for 'advanced manufacturing', which relies on the new information and communication technologies. Interactive robotics, virtual reality and non-destructive testing are all technological building blocks developed by CEA, now approved within a cross-cutting programme, to meet the needs of industry and together build the factories of tomorrow. (author)

  11. Tau/Charm Factory Accelerator Report

    OpenAIRE

    M. E. BiaginiINFN, Laboratori Nazionali Frascati, Italy; R. BoniINFN, Laboratori Nazionali Frascati, Italy; M. BoscoloINFN, Laboratori Nazionali Frascati, Italy; A. ChiarucciINFN, Laboratori Nazionali Frascati, Italy; R. CiminoINFN, Laboratori Nazionali Frascati, Italy; A. ClozzaINFN, Laboratori Nazionali Frascati, Italy; A. DragoINFN, Laboratori Nazionali Frascati, Italy; S. GuiducciINFN, Laboratori Nazionali Frascati, Italy; C. LigiINFN, Laboratori Nazionali Frascati, Italy; G. MazzitelliINFN, Laboratori Nazionali Frascati, Italy; R. RicciINFN, Laboratori Nazionali Frascati, Italy; C. SanelliINFN, Laboratori Nazionali Frascati, Italy; M. SerioINFN, Laboratori Nazionali Frascati, Italy; A. StellaINFN, Laboratori Nazionali Frascati, Italy; S. TomassiniINFN, Laboratori Nazionali Frascati, Italy

    2014-01-01

    The present Report concerns the current status of the Italian Tau/Charm accelerator project and in particular discusses the issues related to the lattice design, to the accelerators systems and to the associated conventional facilities. The project aims at realizing a variable energy Flavor Factory between 1 and 4.6 GeV in the center of mass, and succeeds to the SuperB project from which it inherits most of the solutions proposed in this document. The work comes from a cooperation involving t...

  12. Racetrack lattices for the TRIUMF KAON factory

    International Nuclear Information System (INIS)

    Servranckx, R.V.; Craddock, M.K.

    1989-05-01

    Separated-function racetrack lattices have been developed for the KAON Factory accelerators that have more flexibility than the old circular lattices. The arcs of the large rings have a regular FODO structure with a superimposed six-fold symmetric modulation of the betafunction in order to raise γ t to infinity. In the small rings, γ t is kept high enough by choosing a sufficiently large phase advance in the arcs. Straight sections with zero dispersion are provided for rf cavities and fast injection and extraction, and with controlled dispersion for H - injection and slow extraction. The ion-optical properties of the lattices and the results from tracking studies are discussed

  13. Tests of CPT invariance at neutrino factories

    International Nuclear Information System (INIS)

    Bilenky, Samoil M.; Freund, Martin; Lindner, Manfred; Ohlsson, Tommy; Winter, Walter

    2002-01-01

    We investigate possible tests of CPT invariance on the level of event rates at neutrino factories. We do not assume any specific model but phenomenological differences in the neutrino-antineutrino masses and mixing angles in a Lorentz invariance preserving context, such as could be induced by physics beyond the standard model. We especially focus on the muon neutrino and antineutrino disappearance channels in order to obtain constraints on the neutrino-antineutrino mass and mixing angle differences; we found, for example, that the sensitivity |m 3 -m(bar sign) 3 |(less-or-similar sign)1.9x10 -4 eV could be achieved

  14. Rare B decays at B factories

    International Nuclear Information System (INIS)

    Trabelsi, Karim

    2010-01-01

    Radiative and Electroweak Penguin Decays are Flavor Changing Neutral Currents (FCNC) occurring in the Standard Model only at the loop level. They are characterized by high sensitivity to New Physics (they can appear in the loop with size comparable to leading SM contributions) and they are Complementary to the direct production of new particles expected at LHC. Huge datasets collected at the two B- factories, BaBar and Belle, have made it possible to explore precisely these decays in exclusive channels and inclusive measurements. b →sγ, b→dγ, b→s l + l - , B + →τν, B→Dτν etc measured provide tests of SM predictions and interesting BSM constraints: Charged Higgs bounds from b →sγ, B + →τν, B + →Dτν; Constraints on Wilson coefficients C 7 , C 9 and C 10 ; and Constraints on |V td |/|V ts |. They provide interesting signatures: B(B + →τ + ν) direct measurement versus CKM fit; and large forward-backward asymmetry of K* l + l - . Final Belle/BaBar data samples are yet to be analyzed and even more interesting results are expected at Super B factories with two orders of magnitude larger data samples

  15. Radiation safety design of super KEKB factory

    International Nuclear Information System (INIS)

    Sanami, Toshiya

    2015-01-01

    The SuperKEKB factory, which was scheduled to start operation early 2015, is an electron-positron collider designed to produce an 80x10"3"4-1/cm"2/s luminosity, which is 40 times greater than the KEKB factory. Built to investigate CP violation and 'new physics' beyond the Standard Model, the facility consists of a 7-GeV electron/3.5-GeV positron linac, a 1.1- GeV positron damping ring, beam transport, and a 7-GeV electron/4-GeV positron collider. To meet this level of luminosity, the collider will be operated with a small beam size and a large crossing angle at the interaction point. According to particle tracking simulations, beam losses under these conditions will be 35 times more than those previously operated. To help optimise shielding configurations, leakage radiation and induced activity are estimated through empirical equations and detailed Monte-Carlo simulations using MARS15 code for the interaction region, beam halo collimators, emergency pathways, ducts, forward direction tunnels, and positron production target. Examples of shielding strategies are presented to reduce both leakage dose and airborne activity for several locations in the facility. (authors)

  16. Muon Acceleration: Neutrino Factory and Beyond

    Energy Technology Data Exchange (ETDEWEB)

    Bogacz, Alex [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2018-03-01

    We summarize the current state of a concept for muon acceleration aimed at a future Neutrino Factory and extendable to Higgs Factory. The main thrust of these studies was to reduce the overall cost while maintaining performance by exploring the interplay between the complexity of the cooling systems and the acceptance of the accelerator complex. To ensure adequate survival for the short-lived muons, acceleration must occur at high average gradient. The need for large transverse and longitudinal acceptances drives the design of the acceleration system to an initially low RF frequency, e.g., 325 MHz, which is then increased to 650 MHz as the transverse size shrinks with increasing energy. High-gradient normal conducting RF cavities at these frequencies require extremely high peak-power RF sources. Hence superconducting RF (SRF) cavities are chosen. We consider an SRF-efficient design based on a multi-pass (4.5) ?dogbone? RLA, extendable to multi-pass FFAG-like arcs.

  17. Particle identification at an asymmetric B Factory

    International Nuclear Information System (INIS)

    Coyle, P.; Eigen, G.; Hitlin, D.; Oddone, P.; Ratcliff, B.; Roe, N.; Va'vra, J.; Ypsilantis, T.

    1991-09-01

    Particle identification systems are an important component of any detector at a high-luminosity, asymmetric B Factory. In particular, excellent hadron identification is required to probe CP violation in B 0 decays to CP eigenstates. The particle identification systems discussed below also provide help in separating leptons from hadrons at low momenta. We begin this chapter with a discussion of the physics motivation for providing particle identification, the inherent limitations due to interactions and decays in flight, and the requirements for hermiticity and angular coverage. A special feature of an asymmetric B Factory is the resulting asymmetry in the momentum distribution as a function of polar angle; this will also be quantified and discussed. In the next section the three primary candidates, time-of-flight (TOF), energy loss (dE/dx), and Cerenkov counters, both ring-imaging and threshold, will be briefly described and evaluated. Following this, one of the candidates, a long-drift Cerenkov ring-imaging device, is described in detail to provide a reference design. Design considerations for a fast RICH are then described. A detailed discussion of aerogel threshold counter designs and associated R ampersand D conclude the chapter. 56 refs., 64 figs., 13 tabs

  18. The rehabilitation of ancient gas factory sites

    International Nuclear Information System (INIS)

    Costes, J.M.; Hua, C.

    1996-01-01

    In France, the inheritance of ancient town gas factories, mainly under the responsibility of Gaz de France, has left pollutants in the soils of their sites. The aim of the national company is to control these pollutants. Several hundred of town gas factories were exploited in France from 1798 (date of the invention of the process by Lebon) to the end of the 60's. The town gas, obtained from high temperature pyrogenic decomposition of coal, led to by-products which were stored or mixed with the soil. This paper describes the environmental and quality policy carried out by Gaz de France to characterize and remove the pollutants (coke, clinker, tar, phenols, ammoniated water, hydrogen sulphide, cyanides, benzene, toluene, xylenes..) to evaluate the risks of exposure of contaminants and their possible impact on human health. A method with 17 criteria was elaborated to characterize the sites and the rehabilitation comprises three steps: the environmental audit (evaluation of the concentration of pollutants and of their possible environmental and human impact), the complementary analysis (extension of the contaminated area, nature and concentration of pollutants, geologic and hydrogeologic characterisation of the site), and the rehabilitation itself when necessary (confinement or elimination of pollutants using thermal, physico-chemical or biological treatments). (J.S.)

  19. Optimization of a furniture factory layout

    Directory of Open Access Journals (Sweden)

    Tadej Kanduč

    2015-03-01

    Full Text Available This paper deals with the problem of optimizing a factory floor layout in a Slovenian furniture factory. First, the current state of the manufacturing system is analyzed by constructing a discrete event simulation (DES model that reflects the manufacturing processes. The company produces over 10,000 different products, and their manufacturing processes include approximately 30,000 subprocesses. Therefore, manually constructing a model to include every subprocess is not feasible. To overcome this problem, a method for automated model construction was developed to construct a DES model based on a selection of manufacturing orders and relevant subprocesses. The obtained simulation model provided insight into the manufacturing processes and enable easy modification of model parameters for optimizing the manufacturing processes. Finally, the optimization problem was solved: the total distance the products had to traverse between machines was minimized by devising an optimal machine layout. With the introduction of certain simplifications, the problem was best described as a quadratic assignment problem. A novel heuristic method based on force-directed graph drawing algorithms was developed. Optimizing the floor layout resulted in a significant reduction of total travel distance for the products.

  20. Biosynthesis and function of chondroitin sulfate.

    Science.gov (United States)

    Mikami, Tadahisa; Kitagawa, Hiroshi

    2013-10-01

    Chondroitin sulfate proteoglycans (CSPGs) are principal pericellular and extracellular components that form regulatory milieu involving numerous biological and pathophysiological phenomena. Diverse functions of CSPGs can be mainly attributed to structural variability of their polysaccharide moieties, chondroitin sulfate glycosaminoglycans (CS-GAG). Comprehensive understanding of the regulatory mechanisms for CS biosynthesis and its catabolic processes is required in order to understand those functions. Here, we focus on recent advances in the study of enzymatic regulatory pathways for CS biosynthesis including successive modification/degradation, distinct CS functions, and disease phenotypes that have been revealed by perturbation of the respective enzymes in vitro and in vivo. Fine-tuned machineries for CS production/degradation are crucial for the functional expression of CS chains in developmental and pathophysiological processes. Control of enzymes responsible for CS biosynthesis/catabolism is a potential target for therapeutic intervention for the CS-associated disorders. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. INDOOR THERMAL CONDITION OF FACTORY BUILDING IN BANGLADESH

    OpenAIRE

    Muhammed Abdullah Al Sayem Khan; Mohd. Hamdan Ahmad; Tareef Hayat Khan

    2011-01-01

    Bangladesh is a developing country and has a lot of factories for different products for local use and also export to abroad. Garments industries are one of the top most items of exported items. A huge number of populations are working in garments industries. But these factories are not well designed in sense of the thermal environment. Workers experiences sickness related to indoor environment. The productions of these factories are affected due to employees’ health condition. The research i...

  2. Triterpenoid biosynthesis in Euphorbia lathyris latex

    International Nuclear Information System (INIS)

    Hawkins, D.R.

    1987-11-01

    The structures of triterpenols, not previously been known, from Euphorbia lathyris latex are reported. A method for quantifying very small amounts of these compounds was developed. Concerning the biochemistry of the latex, no exogenous cofactors were required for the biosynthesis and the addition of compounds such as NADPAH and ATP do not stimulate the biosynthesis. The addition of DTE or a similar anti-oxidant was found to help reduce the oxidation of the latex, thus increasing the length of time that the latex remains active. The requirement of a divalent cation and the preference for Mn in the pellet was observed. The effect of several inhibitors on the biosynthesis of the triterpenoids was examined. Mevinolin was found to inhibit the biosynthesis of the triterpenoids from acetate, but not mevalonate. A dixon plot of the inhibition of acetate incorporation showed an I 50 concentration of 3.2 μM. Fenpropimorph was found to have little or no effect on the biosynthesis. Tridemorph was found to inhibit the biosynthesis of all of the triterpenoids with an I 50 of 4 μM. It was also observed that the cyclopropyl containing triterpenols, cycloartenol and 24-methylenecycloartenol were inhibited much more strongly than those containing an 8-9 double bond, lanosterol and 24-methylenelanosterol. The evidence indicates, but does not definetely prove, that lanosterol and 24-methylenelanosterol are not made from cycloartenol and 24-methylenecycloartenol via a ring-opening enzyme such as cycloeucalenol-obtusifoliol isomerase. The possibilty that cycloartenol is made via lanosterol was investigated by synthesizing 4-R-4- 3 H-mevalonic acid and incubating latex with a mixture of this and 14 C-mevalonic acid. From the 3 H/ 14 C ratio it was shown that cycloartenol and 24-methylenecycloartenol are not made via an intermediate containing as 8-9 double bond. 88 refs., 15 figs., 30 tabs

  3. Triterpenoid biosynthesis in Euphorbia lathyris latex

    Energy Technology Data Exchange (ETDEWEB)

    Hawkins, D.R.

    1987-11-01

    The structures of triterpenols, not previously been known, from Euphorbia lathyris latex are reported. A method for quantifying very small amounts of these compounds was developed. Concerning the biochemistry of the latex, no exogenous cofactors were required for the biosynthesis and the addition of compounds such as NADPAH and ATP do not stimulate the biosynthesis. The addition of DTE or a similar anti-oxidant was found to help reduce the oxidation of the latex, thus increasing the length of time that the latex remains active. The requirement of a divalent cation and the preference for Mn in the pellet was observed. The effect of several inhibitors on the biosynthesis of the triterpenoids was examined. Mevinolin was found to inhibit the biosynthesis of the triterpenoids from acetate, but not mevalonate. A dixon plot of the inhibition of acetate incorporation showed an I/sub 50/ concentration of 3.2 ..mu..M. Fenpropimorph was found to have little or no effect on the biosynthesis. Tridemorph was found to inhibit the biosynthesis of all of the triterpenoids with an I/sub 50/ of 4 ..mu..M. It was also observed that the cyclopropyl containing triterpenols, cycloartenol and 24-methylenecycloartenol were inhibited much more strongly than those containing an 8-9 double bond, lanosterol and 24-methylenelanosterol. The evidence indicates, but does not definetely prove, that lanosterol and 24-methylenelanosterol are not made from cycloartenol and 24-methylenecycloartenol via a ring-opening enzyme such as cycloeucalenol-obtusifoliol isomerase. The possibilty that cycloartenol is made via lanosterol was investigated by synthesizing 4-R-4-/sup 3/H-mevalonic acid and incubating latex with a mixture of this and /sup 14/C-mevalonic acid. From the /sup 3/H//sup 14/C ratio it was shown that cycloartenol and 24-methylenecycloartenol are not made via an intermediate containing as 8-9 double bond. 88 refs., 15 figs., 30 tabs.

  4. Convergent Evolution of Ergothioneine Biosynthesis in Cyanobacteria.

    Science.gov (United States)

    Liao, Cangsong; Seebeck, Florian P

    2017-11-02

    Biosynthesis of N-α-trimethyl-2-thiohistidine (ergothioneine) is a frequent trait in cyanobacteria. This sulfur compound may provide essential relief from oxidative stress related to oxygenic photosynthesis. The central steps in ergothioneine biosynthesis are catalyzed by a histidine methyltransferase and an iron-dependent sulfoxide synthase. In this report, we present evidence that some cyanobacteria recruited and adapted a sulfoxide synthase from a different biosynthetic pathway to make ergothioneine. The discovery of a second origin of ergothioneine production underscores the physiological importance of this metabolite and highlights the evolutionary malleability of the thiohistidine biosynthetic machinery. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Method for determining heterologous biosynthesis pathways

    KAUST Repository

    Gao, Xin

    2017-08-10

    The present invention relates to a method and system for dynamically analyzing, determining, predicting and displaying ranked suitable heterologous biosynthesis pathways for a specified host. The present invention addresses the problem of finding suitable pathways for the endogenous metabolism of a host organism because the efficacy of heterologous biosynthesis is affected by competing endogenous pathways. The present invention is called MRE (Metabolic Route Explorer), and it was conceived and developed to systematically and dynamically search for, determine, analyze, and display promising heterologous pathways while considering competing endogenous reactions in a given host organism.

  6. Nucleoside antibiotics: biosynthesis, regulation, and biotechnology.

    Science.gov (United States)

    Niu, Guoqing; Tan, Huarong

    2015-02-01

    The alarming rise in antibiotic-resistant pathogens has coincided with a decline in the supply of new antibiotics. It is therefore of great importance to find and create new antibiotics. Nucleoside antibiotics are a large family of natural products with diverse biological functions. Their biosynthesis is a complex process through multistep enzymatic reactions and is subject to hierarchical regulation. Genetic and biochemical studies of the biosynthetic machinery have provided the basis for pathway engineering and combinatorial biosynthesis to create new or hybrid nucleoside antibiotics. Dissection of regulatory mechanisms is leading to strategies to increase the titer of bioactive nucleoside antibiotics. Copyright © 2014. Published by Elsevier Ltd.

  7. Biosynthesis of silver nanoparticles by Aspergillus niger , Fusarium ...

    African Journals Online (AJOL)

    ... scanning electron microscope (SEM). Results indicate the synthesis of silver nanoparticles in the reaction mixture. The synthesis of nanoparticles would be suitable for developing a microbial nanotechnology biosynthesis process for mass scale production. Keywords: Silver nanoparticles, biosynthesis, fungi, Aspergillus.

  8. Análise factorial confirmatória do TEOSQp Confirmatory factorial analysis of TEOSQp

    Directory of Open Access Journals (Sweden)

    Helder M. Fernandes

    2010-04-01

    Full Text Available O propósito do presente estudo foi avaliar a confiabilidade, a validade factorial e a invariância (por sexo da versão portuguesa do TEOSQ (Fonseca & Biddle, 2001. Integraram a amostra 1010 estudantes com uma média de idade de 15,42 anos. A análise factorial e da invariância foi avaliada através da análise factorial confirmatória. Os resultados corroboram a proposta de uma estrutura de duas subescalas (tarefa e ego. Com base nos índices de modificação e justificação teórica, o TEOSQ p foi reduzido a 12-itens, com melhores índices de adequação para o modelo oblíquo. Os resultados relativos à invariância por sexo não apresentaram apoio empírico total para a assumpção de equivalência multi-grupo, sugerindo que o TEOSQ p não parece avaliar as orientações cognitivas do mesmo modo, para os indivíduos do sexo masculino (modelo ortogonal e feminino (modelo oblíquo. Face aos resultados obtidos, foram discutidas as implicações conceptuais, empíricas, assim como os aspectos de carácter aplicado.The present research assessed the reliability, factorial validity and measurement invariance (by gender of the Portuguese version of TEOSQ -Task and Ego Orientation in Sport Questionnaire (Fonseca & Biddle, 2001. Data were collected from 1010 physical education students with a mean age of 15.42 ( SD=1.91. Factorial and invariance measurements were tested via confirmatory factorial analysis. Results supported internal consistency for the two proposed subscales (task and ego. Based on modification indices and theoretical justification the TEOSQ p was reduced to 12 items with better goodness-of-fit indices for the oblique model. The results of gender invariance did not provide full empirical support to the multi-group equivalence assumption, being suggested that TEOSQ p does not measure in the same way goal orientations for boys (orthogonal model and girls (oblique model. In light of these results, conceptual, empirical and practical

  9. [Demodicosis of dogs--a factorial disease?].

    Science.gov (United States)

    Gothe, R

    1989-09-01

    Demodex canis is a normal resident of the intact canine skin, being present in small numbers in virtually every dog. Most animals are only carriers of the mites and do not develop clinical symptoms, therefore, demodectic mange has already to be considered as a factorial disease. The modus operandi of transition of clinically inapparent colonization of the mites into a disease may be explained according to investigations so far published multifactorially and thereby essentially as consequences of primary or secondary immunodepression. A primary immunodepression is initially based most probably on a hereditary defect of T-cells and is subsequently reinforced by substances, which are presumably synthesized and liberated not only by mites but also by secondary bacterial agents. A secondary immunodepression operates as trigger mechanism of a clinical manifestation after corticosteroid or cytostatic therapy or in course of underlying diseases of potentially immunodepressive nature, i.e., malignant neoplasia, hepatopathies, hyperadrenocorticism and lymphosarcoma.

  10. ATHEROSCLEROSIS DISEASE: A MULTI-FACTORIAL PATHOLOGY

    Directory of Open Access Journals (Sweden)

    Marcieli da Luz Giroldo1; Arienne Serrano Alves1; Francielle Baptista1

    2007-06-01

    Full Text Available Atherosclerosis or arterial stiffening is a gradual disease that restricts the normal blood flow in different areas of body and maylead to secondary illnesses as myocardial infarction and cerebral stroke. Innumerable factors are related to the development ofatherosclerosis, among them are the dyslipidemia; genetic factors; arterial hypertension; diabetes mellitus; obesity; smoking;lack of exercise; pulmonary infection by Chlamydia and stress. Due to multi-factorial atherosclerosis characteristics,innumerable drugs, with differentiated mechanisms of action, are being elaborated to be used in prevention and control of thisdisease. However, beyond the pharmacological therapy, a balanced diet, physical activity and elimination of risk habits, assmoking, also are need for controlling atherosclerosis progression, as well as for the increase of expectative and quality of life

  11. Nuclear structure physics at RI beam factory

    International Nuclear Information System (INIS)

    Otsuka, Takaharu

    1998-01-01

    The nuclear structure physics is becoming extremely interesting owing to recent development of RI beam factories. Among various interesting developments in this field, I will focus upon two subjects. One is the breaking of the usual magic numbers in unstable nuclei, and the other is the invention of a new method for quantum many-body problems: Quantum Monte Carlo diagonalization method (QMCD). For the first subject, I will discuss the vanishing of N=8 and 20 magic numbers in 11 Li and 32 Mg, respectively. For the latter, I will present brief description of the theory and results of some applications including the one to 64 Ge, a proton-rich unstable nucleus. (author)

  12. The B-factory project at KEK

    International Nuclear Information System (INIS)

    Kurokawa, Shin-ichi; Satoh, Kotaro

    1993-01-01

    The B-Factory project at KEK aims at constructing an accelerator complex which enables us to detect the CP-violation effect of B-mesons. It is a two-ring electron-positron collider of 3.5x8 GeV in the existing TRISTAN tunnel. The design peak luminosity is 10 34 cm -2 s -1 , which will be realized in two steps: from a small-angle collision with a luminosity of 2x10 33 cm -2 s -1 to a large-angle crab-crossing scheme with the final luminosity of 10 34 cm -2 s -1 . Progress of design work and present status of R and D are reported. (author)

  13. N-Nitrosamines in the factory environment

    Energy Technology Data Exchange (ETDEWEB)

    Fajen, J M; Fine, D H; Rounbehler, D P

    1980-01-01

    Under the NIOSH-sponsored contract, a total of 40 surveys were conducted at 28 manufacturing plants. The industries investigated were the fish, dye, leather, rubber and manufacturers and users of cutting fluids. NDELA, NMOR, NDMA and NDPhA were found in the air of several factories. In a chrome tannery, NDMA was identified at levels as high as 47 micrograms/m3 and NMOR was found at 27 micrograms/m3 in a rubber tire plant. This study has resulted in an increased understanding of man's exposure to exogenous N-nitrosamines. It is conceivable, from the information obtained in this study, that nitrosamine exposure comparable to that in the tire and rubber industry exists in other industries not yet surveyed. NIOSH is continuing its research on nitrosamines in the industrial environment. A full, industry-wide report on the 40 plant surveys is being compiled for publication.

  14. Lattices for the TRIUMF KAON factory

    International Nuclear Information System (INIS)

    Servranckx, R.V.; Craddock, M.K.

    1989-09-01

    Separated-function racetrack lattices have been developed for the KAON Factory accelerators that have more flexibility than the old circular lattices. The arcs of the large rings have a regular FODO structure with a superimposed six-fold symmetric modulation of the betafunction in order to raise γ t to infinity. Straight sections with zero dispersion are provided for rf cavities and fast injection and extraction, and with controlled dispersion for H - injection and slow extraction. For the small rings, sixfold symmetric circular lattices with high γ t are retained. In the Accumulator lattice, a straight section with double waist and controlled η function allows for H - injection and phase-space painting. The ion-optical properties of the lattices and the results from tracking studies are discussed

  15. Intense muon beams and neutrino factories

    International Nuclear Information System (INIS)

    Parsa, Z.

    2000-01-01

    High intensity muon sources are needed in exploring neutrino factories, lepton flavor violating muon processes, and lower energy experiments as the stepping phase towards building higher energy μ + μ - colliders. We present a brief overview, sketch of a neutrino source, and an example of a muon storage ring at BNL with detector(s) at Fermilab, Sudan, etc. Physics with low energy neutrino beams based on muon storage rings (μSR) and conventional Horn Facilities are described and compared. CP violation Asymmetries and a new Statistical Figure of Merit to be used for comparison is given. Improvements in the sensitivity of low energy experiments to study Flavor changing neutral currents are also included

  16. Producción escrita: Estructura factorial

    Directory of Open Access Journals (Sweden)

    María Esperanza HERRERA GARCÍA

    2009-11-01

    Full Text Available Este estudio se planteó con la idea de comprobar de forma empírica si los indicadores lingüísticos obtenidos en investigaciones realizadas sobre comprensión lectora aparecían también como significativos en el análisis de la producción escrita. Si bien la investigación psicológica ha demostrado en numerosas ocasiones la relación existente entre comprensión y producción en el sentido de una maduración anterior de la primera con respecto a la segunda, podemos considerar a priori la existencia de indicadores que nos permitan medir ambos aspectos. Para ello buscamos la estructura factorial que presentan los indicadores lingüísticos que vamos a considerar y comprobaremos si presenta los factores encontrados en comprensión lectora.

  17. Targeting population heterogeneity for optimal cell factories

    DEFF Research Database (Denmark)

    Heins, Anna-Lena; Carlqvist, Magnus; Helmark, S.

    the heterogeneity level of the population. To further investigate these phenomena and gain a deeper understanding of population heterogeneity, Saccharomyces cerevisiae growth reporter strains based on the expression of green fluorescent protein (GFP) were constructed which enabled us to perform single cell level...... analysis, and thereby created the possibility to map population heterogeneity. A factorial design with pH, glucose concentration and oxygen level was performed in batch cultivations using the growth reporter strains to evaluate the effect of those environmental factors on heterogeneity level and amount......To achieve an efficient production process, it is essential to optimize both the strain and the cultivation conditions. Traditionally, a microbial population has been considered homogeneous in optimization studies of fermentation processes. However, research has shown that a typical microbial...

  18. High-gravity brewing utilizing factorial design

    Directory of Open Access Journals (Sweden)

    R. B. Almeida

    2000-06-01

    Full Text Available A number of factors can influence the behavior of yeast during fermentation. Some of these factors (initial wort concentration, initial pH and percentage of corn syrup in the composition of the wort were studied in order to determine their influence on the productivity of fermentation. Fermentations were carried out at 25ºC utilizing a 2³ factorial design of these factors. The results showed that the percentage of corn syrup had no influence on process productivity, whereas initial pH and especially initial wort concentration did. It can be concluded that using pH and initial wort concentration values higher than those utilized in this work (5.5 and 20ºP, respectively will result in a higher productivity.

  19. Present status of positron factory project

    International Nuclear Information System (INIS)

    Okada, S.; Sunaga, H.; Kaneko, H.; Tachibana, H.; Yotsumoto, K.; Okamoto, J.

    1992-01-01

    The Japan Atomic Energy Research Institute, JAERI, has been promoting design studies for the 'Positron Factory', in which linac-based intense monoenergetic positron beams are planned to be applied to advanced materials characterization and new fields of basic research. A tentative goal of the beam intensity is 10 10 s -1 , which is assumed to be realized with an electron linac of 100 kW class with a beam energy around 100 to 150 MeV. We performed a technical survey on the dedicated linac. It confirmed technical feasibility of manufacturing the state-of-the-art machine. We have been carrying out a design study of the target. A new concept of the target design is proposed, which is expected to supply intense slow positron beams simultaneously for multiple beam channels, on the basis of Monte Carlo simulations. (author)

  20. Achille Maramotti, between factory and collection

    Directory of Open Access Journals (Sweden)

    Chiara Pirozzi

    2016-11-01

    Full Text Available The article analyzes Achille Maramotti’s figure and links between entrepreneurship and his passion for art and contemporary collections: from the desire to expose his private collection inside Max Mara factory to create a collection that was the mirror of the artistic experiments of his time. The article analyzes the critical contributions in the development of Maramotti Collection and, in particular, the relationship between Achille Maramotti and Mario Diacono that, as the Emilian collector, is expert and admirer of European and American painting of the second half of the twentieth century. Achille Maramotti, sons and daughter are considered among the most influential collectors in the world, and represents a successful example of contemporary art collection linked to the image and business management; the Max Mara fashion house.

  1. KEKB and PEP-II B Factories

    International Nuclear Information System (INIS)

    Seeman, J.T.

    1997-01-01

    Two asymmetric B-Factories KEKB at KEK and PEP-II at SLAC are under construction, designed to study CP violation in the b-quark sector with a center of mass energy of 10.58 GeV. These two new accelerators are high luminosity two-ring two-energy e + e - colliders with one interaction point. There are many challenging accelerator physics and engineering issues associated with the high beam currents and high luminosities of these rings. The chosen solutions to these issues and the general parameters of the two rings are described in detail side-by-side. KEKB and PEP-II are well into the installation phase and are both scheduled to be completed in 1998. The particle physics programs are scheduled to start in 1999

  2. Status of the TRIUMF KAON factory proposal

    International Nuclear Information System (INIS)

    Craddock, M.K.

    1988-03-01

    Over the last year considerable progress has been achieved on both technical and political fronts. Hardware studies have continued on both magnet power supplies and on rf cavities - the latter work gaining an extra dimension from a recently-instituted formal collaboration with LAMPF. A racetrack-shaped lattice is being considered in conjunction with a three-element slow extraction system in an effort to reduce losses to the 0.1% level. British Columbia has agreed to fund the buildings and tunnels (Cdn $87M) and is making the KAON Factory its tope priority project with the Canadian federal government. A joint federal-provincial delegation has traveled abroad and found that a number of countries would consider significant contributions to the cost. Government approval contingent upon such contributions is anticipated later in 1988, together with preconstruction R and D funds

  3. Improved premises for cell factory development

    DEFF Research Database (Denmark)

    Søgaard, Karina Marie

    The sustainable manufacturing of medicines, materials and chemicals is enabled with biotechnology, and the key to the development of new processes, as well as improvement of existing ones, lies in our fundamental understanding of the biological systems we manipulate. Recombinant protein production...... is at the core of biotechnology and numerous molecular tools and bacterial strains have been developed over the past four decades for this purpose. Understanding of the genetic code and our ability to manipulate genetic material, paves the way for the microbial cell factory development that enables production......, and building a platform for enhanced expression of certain plant genes in bacteria. The relevance of the conducted research to the field of biotechnology is covered, as well as necessary scientific background and history. Specifically, the surprisingly minor effects of tRNA overexpression on the production...

  4. Golden measurements at a neutrino factory

    International Nuclear Information System (INIS)

    Cervera, A.; Donini, A.; Gavela, M.B.; Gomez Cadenas, J.J.; Hernandez, P.; Mena, O.; Rigolin, S.

    2000-01-01

    The precision and discovery potential of a neutrino factory based on muon storage rings is studied. For three-family neutrino oscillations, we analyse how to measure or severely constraint the angle θ 13 , CP-violation, MSW effects and the sign of the atmospheric mass difference Δm 2 23 . We present a simple analytical formula for the oscillation probabilities in matter, with all neutrino mass differences non-vanishing, which clarifies the subtleties involved in disentangling the unknown parameters. The appearance of 'wrong-sign muons' at three reference baselines is considered: 732 km, 3500 km, and 7332 km. We exploit the dependence of the signal on the neutrino energy, and include as well realistic background estimations and detection efficiencies. The optimal baseline turns out to be O (3000 km). Analyses combining the information from different baselines are also presented

  5. Golden measurements at a neutrino factory

    CERN Document Server

    Cervera-Villanueva, Anselmo; Gavela-Legazpi, Maria Belen; Cadenas, J J G; Hernández, Pilar; Mena, O; Rigolin, Stefano

    2000-01-01

    The precision and discovery potential of a neutrino factory based on muonstorage rings is studied. For three-family neutrino oscillations, we analysehow to measure or severely constraint the angle $\\theta_{13}$, CP violation,MSW effects and the sign of the atmospheric mass difference $\\Delta m^2_{23}$.We present a simple analytical formula for the oscillation probabilities inmatter, with all neutrino mass differences non-vanishing, which clarifies thesubtleties involved in disentangling the unknown parameters. The appearance of``wrong-sign muons'' at three reference baselines is considered: 732 km, 3500km, and 7332 km. We exploit the dependence of the signal on the neutrinoenergy, and include as well realistic background estimations and detectionefficiencies. The optimal baseline turns out to be ${\\cal O}(3000$ km).Analyses combining the information from different baselines are also presented.

  6. Evolution of the Factory 1975-2006

    International Nuclear Information System (INIS)

    2006-01-01

    Since it was founded in 1973. Equipos Nucleares (ENSA) has been actively present in the nuclear market. This was the reason for its creation and for which it was organized from the very beginning, by designing a company with a nuclear structure and mentality. The author reviews the history and evolution of the Factory- more than a workshop- and describes its different stages, which were strongly affected by the unexpected evolution of a diminishing market- an inexistent market the likes to say- and also stresses the extraordinary difficulty of its work and the determination to remain in the nuclear market. He acknowledges the people and the culture of ENSA emphasizing their dedication, generosity, flexibility, training and enthusiasm, and stresses their stake in being the best and to attain excellence in the quality of supplies, meeting deadlines and customer satisfaction, identifying these as fundamental factors of the company's legacy. Having a better Factory is possible by improving its technological capability through researching and developing its processes, automating and robotizing manufacturing and inspection activities, and simplifying its operating systems. A result of these efforts is the continuous international presence as a supplier and collaborator with the world's leading designers, which has consolidated it as a reference supplier on the American market. Of not is the supply to the market of its different product lines a result of combining its design and manufacturing capabilities with its flexibility and size, all of which contribute to ENSA's wealth, diversity and appeal. ENSA is aware of the forthcoming resurgence of the new nuclear market. It is preparing for the future by renewing and upgrading its manufacturing facilities and implementing new systems techniques- Lean Manufacturing and Six Sigma-into its Annual Improvement Plans to favor and drive its technological capability and competitiveness and to respond to the increasingly demanding

  7. Combinatorial biosynthesis of medicinal plant secondary metabolites

    NARCIS (Netherlands)

    Julsing, Mattijs K.; Koulman, Albert; Woerdenbag, Herman J.; Quax, Wim J.; Kayser, Oliver

    2006-01-01

    Combinatorial biosynthesis is a new tool in the generation of novel natural products and for the production of rare and expensive natural products. The basic concept is combining metabolic pathways in different organisms on a genetic level. As a consequence heterologous organisms provide precursors

  8. Peroxidase enzymes regulate collagen extracellular matrix biosynthesis.

    Science.gov (United States)

    DeNichilo, Mark O; Panagopoulos, Vasilios; Rayner, Timothy E; Borowicz, Romana A; Greenwood, John E; Evdokiou, Andreas

    2015-05-01

    Myeloperoxidase and eosinophil peroxidase are heme-containing enzymes often physically associated with fibrotic tissue and cancer in various organs, without any direct involvement in promoting fibroblast recruitment and extracellular matrix (ECM) biosynthesis at these sites. We report herein novel findings that show peroxidase enzymes possess a well-conserved profibrogenic capacity to stimulate the migration of fibroblastic cells and promote their ability to secrete collagenous proteins to generate a functional ECM both in vitro and in vivo. Mechanistic studies conducted using cultured fibroblasts show that these cells are capable of rapidly binding and internalizing both myeloperoxidase and eosinophil peroxidase. Peroxidase enzymes stimulate collagen biosynthesis at a post-translational level in a prolyl 4-hydroxylase-dependent manner that does not require ascorbic acid. This response was blocked by the irreversible myeloperoxidase inhibitor 4-amino-benzoic acid hydrazide, indicating peroxidase catalytic activity is essential for collagen biosynthesis. These results suggest that peroxidase enzymes, such as myeloperoxidase and eosinophil peroxidase, may play a fundamental role in regulating the recruitment of fibroblast and the biosynthesis of collagen ECM at sites of normal tissue repair and fibrosis, with enormous implications for many disease states where infiltrating inflammatory cells deposit peroxidases. Copyright © 2015 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  9. Biosynthesis of polyhydroxyalkanotes in wildtype yeasts | Desuoky ...

    African Journals Online (AJOL)

    Biosynthesis of the biodegradable polymers polyhydroxyalkanotes (PHAs) are studied extensively in wild type and genetically modified prokaryotic cells, however the content and structure of PHA in wild type yeasts are not well documented. The purpose of this study was to screen forty yeast isolates collected from different ...

  10. Metabolic engineering for improved heterologous terpenoid biosynthesis

    NARCIS (Netherlands)

    Ryden, A.; Melillo, E.; Czepnik, M.; Kayser, O.

    Terpenoids belong to the largest class of natural compounds and are produced in all living organisms. The isoprenoid skeleton is based on assembling of C5 building blocks, but the biosynthesis of a great variety of terpenoids ranging from monoterpenoids to polyterpenoids is not fully understood

  11. Biosynthesis of silver nanoparticles synthesized by Aspergillus

    Indian Academy of Sciences (India)

    In the present study, biosynthesis of silver nanoparticles and its antioxidant, antimicrobial and cytotoxic activities were investigated. Silver nanoparticles were extracellularly synthesized using Aspergillus flavus and the formation of nanoparticles was observed after 72 h of incubation. The results recorded from colour ...

  12. Biosynthesis of furanochromones in Pimpinella monoica

    Indian Academy of Sciences (India)

    polyketide origin of their aromatic and pyrone rings while the furan ring originates via an acetate-mevalonate pathway. The plant also utilises glycine and leucine as substrate via acetate. Biotransformation of 3-H-visnagin to (6) but not to (2) was also observed. Keywords. Biosynthesis; furochromones; polyketide origin; ...

  13. Oil fuel delivery optimization for multi product and multi depot: the case of petrol station replenishment problem (PSRP)

    Science.gov (United States)

    Surjandari, Isti; Rachman, Amar; Dianawati, Fauzia; Wibowo, R. Pramono

    2011-10-01

    With the Oil and Gas Law No. 22 of 2001, national and foreign private enterprises can invest in all sectors of Oil and Gas in Indonesia. In anticipation of this free competition, Pertamina, as a state-owned enterprises, which previously had monopolized the oil and gas business activities in Indonesia, should be able to improve services as well as the efficiency in order to compete in the free market, especially in terms of cost efficiency of fuel distribution to gas station (SPBU). To optimize the distribution activity, it is necessary to design a scheduling system and its fuel delivery routes daily to every SPBU. The determination of routes and scheduling delivery of fuel to the SPBU can be modeled as a Petrol Station Replenishment Problem (PSRP) with the multi-depot, multi-product, time windows and split deliveries, which in this study will be completed by the Tabu Search algorithm (TS). This study was conducted in the area of Bandung, the capital of West Java province, which is a big city and the neighboring city of Jakarta, the capital city of Indonesia. By using the fuel delivery data for one day, the results showed a decrease of 16.38% of the distance of the route compared to the current conditions, which impacted on the reduction of distribution costs and decrease the number of total trips by 5.22% and 3.83%.

  14. Proceedings of the Workshop on CP Violation at KAON Factory

    International Nuclear Information System (INIS)

    Ng, J.N.

    1989-07-01

    These proceedings contain the written version of eight talks delivered at the Workshop on CP Violation at KAON Factory. The articles contain reviews on the exploration of CP violation effects associated with the s-quark. Discussion on the use of intense kaon fluxes, which will be available at the proposed KAON Factory, are included

  15. Factory Gate Pricing: An Analysis of the Dutch Retail Distribution

    NARCIS (Netherlands)

    H.M. le Blanc; F. Cruijssen (Frans); H.A. Fleuren; M.B.M. de Koster (René)

    2004-01-01

    textabstractFactory Gate Pricing (FGP) is a relatively new phenomenon in retail distribution. Under FGP, products are no longer delivered at the retailer distribution center, but collected by the retailer at the factory gates of the suppliers. Owing to both the asymmetry in the distribution networks

  16. Factory Gate Pricing : An Analysis of the Dutch Retail Distribution

    NARCIS (Netherlands)

    Le Blanc, H.M.; Cruijssen, F.C.A.M.; Fleuren, H.A.; de Koster, M.B.M.

    2004-01-01

    Factory Gate Pricing (FGP) is a relatively new phenomenon in retail distribution.Under FGP, products are no longer delivered at the retailer distribution center, but collected by the retailer at the factory gates of the suppliers.Owing to both the asymmetry in the distribution networks (the supplier

  17. Parametric study of a target factory for laser fusion

    International Nuclear Information System (INIS)

    Sherohman, J.W.; Meier, W.R.

    1980-01-01

    An analysis of a target factory leading to the derivation of production rate equations has provided the basis for a parametric study. Rate equations describing the production of laser fusion targets have been developed for the purpose of identifying key parameters, attractive production techniques and cost scaling relationships for a commercial target factory

  18. Why and how to normalize the factorial moments of intermittency

    International Nuclear Information System (INIS)

    Peschanski, R.

    1990-01-01

    The normalization of factorial moments of intermittency, which is often the subject of controverses, is justified and (re-)derived from the general assumption of multi-Poissonian statistical noise in the production of particles at high-energy. Correction factors for the horizontal vs. Vertical analyses are derived in general cases, including the factorial multi-bin correlation moments

  19. Review of U.S. Neutrino Factory Studies

    International Nuclear Information System (INIS)

    Zisman, Michael S.

    2005-01-01

    We summarize the status of the two U.S. feasibility studies carried out by the Neutrino Factory and Muon Collider Collaboration (NFMCC) along with recent improvements to Neutrino Factory design developed during the American Physical Society (APS) Neutrino Physics Study. Suggested accelerator topics for the International Scoping Study (ISS) are also indicated

  20. Review of Hosein Aabad Sugar Factory (HASF) Wastewater and ...

    African Journals Online (AJOL)

    Sugar industry is one of the largest industries in the world. Hosein Abad sugar factory (HASF) is located in Hamadan province of Iran. The aim of this research was to evaluate the quality and quantity of wastewater of the said factory and to estimate the pollution load and its emission factor as prerequisite of the management ...

  1. The Three-dimensional Digital Factory for Shipbuilding Technology Research

    Directory of Open Access Journals (Sweden)

    Xu Wei

    2016-01-01

    Full Text Available The three-dimensional digital factory technology research is the hotspot in shipbuilding recently. The three-dimensional digital factory technology not only focus on design the components of the product, but also discuss on the simulation and analyses of the production process.Based on the three-dimensional model, the basic data layer, application control layer and the presentation layer of hierarchical structure are established in the three-dimensional digital factory of shipbuilding in this paper. And the key technologies of three-dimensional digital factory of shipbuilding are analysed. Finally, a case study is applied and the results show that the three-dimensional digital factory will play an important role in the future.

  2. The Experience Factory: Strategy and Practice

    Science.gov (United States)

    Basili, Victor R.; Caldiera, Gianluigi

    1995-01-01

    The quality movement, that has had in recent years a dramatic impact on all industrial sectors, has recently reached the system and software industry. Although some concepts of quality management, originally developed for other product types, can be applied to software, its specificity as a product which is developed and not produced requires a special approach. This paper introduces a quality paradigm specifically tailored on the problem of the systems and software industry. Reuse of products, processes and experiences originating from the system life cycle is seen today as a feasible solution to the problem of developing higher quality systems at a lower cost. In fact, quality improvement is very often achieved by defining and developing an appropriate set of strategic capabilities and core competencies to support them. A strategic capability is, in this context, a corporate goal defined by the business position of the organization and implemented by key business processes. Strategic capabilities are supported by core competencies, which are aggregate technologies tailored to the specific needs of the organization in performing the needed business processes. Core competencies are non-transitional, have a consistent evolution, and are typically fueled by multiple technologies. Their selection and development requires commitment, investment and leadership. The paradigm introduced in this paper for developing core competencies is the Quality Improvement Paradigm which consists of six steps: (1) Characterize the environment, (2) Set the goals, (3) Choose the process, (4) Execute the process, (5) Analyze the process data, and (6) Package experience. The process must be supported by a goal oriented approach to measurement and control, and an organizational infrastructure, called Experience Factory. The Experience Factory is a logical and physical organization distinct from the project organizations it supports. Its goal is development and support of core competencies

  3. Engineering Pseudomonas for phenazine biosynthesis, regulation, and biotechnological applications: a review.

    Science.gov (United States)

    Bilal, Muhammad; Guo, Shuqi; Iqbal, Hafiz M N; Hu, Hongbo; Wang, Wei; Zhang, Xuehong

    2017-10-03

    Pseudomonas strains are increasingly attracting considerable attention as a valuable bacterial host both for basic and applied research. It has been considered as a promising candidate to produce a variety of bioactive secondary metabolites, particularly phenazines. Apart from the biotechnological perspective, these aromatic compounds have the notable potential to inhibit plant-pathogenic fungi and thus are useful in controlling plant diseases. Nevertheless, phenazines production is quite low by the wild-type strains that necessitated its yield improvement for large-scale agricultural applications. Metabolic engineering approaches with the advent of plentiful information provided by systems-level genomic and transcriptomic analyses enabled the development of new biological agents functioning as potential cell factories for producing the desired level of value-added bioproducts. This study presents an up-to-date overview of recombinant Pseudomonas strains as the preferred choice of host organisms for the biosynthesis of natural phenazines. The biosynthetic pathway and regulatory mechanism involved in the phenazine biosynthesis are comprehensively discussed. Finally, a summary of biological functionalities and biotechnological applications of the phenazines is also provided.

  4. The factorial structure of pathological gambling.

    Science.gov (United States)

    Steel, Z; Blaszczynski, A

    1996-03-01

    Pathological gambling has been characterised by DSM-III-R and DSM-IV as a disorder of impulse control with a proportion of gamblers identified as meeting criteria for a co-morbid diagnosis of Antisocial Personality Disorder. To date, empirical evidence in support of the notion that pathological gamblers as a group manifest elevated traits of impulsivity remains equivocal. Principal components analysis was used to investigate relationships between the constructs of impulsivity, psychopathy, DSM-III-R criteria for Antisocial Personality Disorder, psychological distress, criminal offending behavior and a range of other common psychological measures employed with pathological gamblers. The sample comprised 115 pathological gamblers, 80 consecutive gamblers seeking treatment from a general hospital psychiatric inpatient behavior therapy unit, and 35 volunteer Gamblers Anonymous attenders. Four primary factors were determined: psychological distress, sensation seeking, crime and liveliness, and impulsive-antisocial. Results suggest that pathological gambling consists of a number of discrete and reproducible factorial structures. The impulsive antisocial factor was found to be associated with gambling behavior and indices of poor psychosocial functioning.

  5. Hospitals as factories of medical garbage.

    Science.gov (United States)

    Hodges, Sarah

    2017-12-01

    Over the course of the twentieth century, as hospitals cleaned up, they came to produce more and more rubbish. Beginning in the 1970s and gaining pace in the 1980s and 1990s, single-use plastic items (syringes, blood bags, tubing) saturated everyday medical practice across the globe. This essay brings the question of plastic to bear upon the longer history of twentieth century sanitary science. The widespread adoption of single-use disposable medical plastics consolidated a century's worth of changes in medical hygiene. As strange as it may seem today, the initial uptake of medical plastics was not driven primarily by concerns about hygiene. Plastic began as a mid-century technology of convenience and durability. It was not until the end of the twentieth century that it morphed into a powerful symbol and instrument of medical hygiene. Today, both patients and practitioners have embraced plastic as an indispensable technology of clean medicine. The procession of single-use medical plastics through everyday medicine now comprises a constant, if disposable, infrastructure of medical hygiene. This new processional infrastructure of disposable hygiene has produced another, albeit unintended, consequence. This new regime has exponentially increased hospitals' material outputs. In so doing, plastic has refigured the ecologies of everyday medicine. Plastic hygiene has rendered hospitals factories of medical garbage.

  6. New Physics at a Super Flavor Factory

    CERN Document Server

    Browder, Thomas E; Pirjol, Dan; Soni, Amarjit; Zupan, Jure

    2009-01-01

    The potential of a Super Flavor Factory (SFF) for searches of New Physics is reviewed. While very high luminosity B physics is assumed to be at the core of the program, its scope for extensive charm and tau studies are also emphasized. The possibility to run at the Upsilon(5S) as well as at the Upsilon(4S) is also very briefly discussed; in principle, this could provide very clean measurements of B_s decays. The strength and reach of a SFF is most notably due to the possibility of examining an impressive array of very clean observables. The angles and the sides of the unitarity triangle can be determined with unprecedented accuracy. These serve as a reference for New Physics (NP) sensitive decays such as B^+ ->tau^+ nu and penguin dominated hadronic decay modes, providing tests of generic NP scenarios with an accuracy of a few percent. Besides, very precise studies of direct and time dependent CP asymmetries in radiative B decays and forward-backward asymmetry studies in B -> X_s l^+ l^- and numerous null tes...

  7. Shielding design of RIKEN RI Beam Factory

    Energy Technology Data Exchange (ETDEWEB)

    Uwamino, Yoshitomo; Fukunishi, Nobuhisa [Institute of Physical and Chemical Research, Wako, Saitama (Japan); Oishi, Koji [Shimizu Corp., Tokyo (Japan)

    2000-03-01

    Construction of the RIKEN RI Beam Factory is started, and the phase 1 will be finished by the end of March 2003. Two ring cyclotrons including one superconducting machine and two Big RIPSs will be constructed in the phase 1. Heavy ions of proton to uranium will be accelerated up to 400 MeV/u (A<40) and 150 MeV/u for uranium at an intensity of 10{sup 13} pps. Neutron production by the 400 MeV/u {sup 20}Ne beam was measured at HIMAC of NIRS and it was used for the source term of the shielding calculations. The deep penetration of high-energy neutrons was calculated by using the ANISN code with the DLC-119/HILO86R group constants and also by using the HETC code. The ANISN results were modified by using the HETC results and the shielding experiment at ISIS, and they were fitted by a simple formula for practical use. High-energy neutron penetrations of slantwise injection and the reflection probabilities of iron slab were calculated with the HETC code, and these results were used for the estimation of the thickness for the iron local shielding of Big RIPSs. Induced radioactivity in the air, accelerator components and the building, and the skyshine effect were also estimated. (author)

  8. The Gamma Factory proposal for CERN

    CERN Document Server

    Krasny, Mieczyslaw Witold

    2015-01-01

    This year, 2015, marks the centenary of the publication of Einsteins Theory of General Relativity and it has been named the International Year of Light and light-based technologies by the UN General Assembly. It is thus timely to discuss the possibility of broadening the present CERN research program by including a new component based on a novel concept of the light source which could pave a way towards a multipurpose Gamma Factory. The proposed light source could be realized at CERN by using the infrastructure of the existing accelerators. It could push the intensity limits of the presently operating light-sources by at least 7 orders of magnitude, reaching the flux of the order of 10^17 photons/s, in the particularly interesting gamma-ray energy domain of 1 < Ephoton < 400 MeV. This domain is out of reach for the FEL-based light sources. The energy-tuned, quasi-monochromatic gamma beams, together with the gamma-beam-driven, high intensity secondary beams of polarized positrons, polarized muons, neutro...

  9. Survivor shielding. Part A. Nagasaki factory worker shielding

    International Nuclear Information System (INIS)

    Santoro, Robert T.; Barnes, John M.; Azmy, Yousry Y.; Kerr, George D.; Egbert, Stephen D.; Cullings, Harry M.

    2005-01-01

    Recent investigations based on conventional chromosome aberration data by the RERF suggest that the DS86 doses received by many Nagasaki factory workers may have been overestimated by as much as 40% relative to those for other survivors in Japanese-type houses and other shielding configurations (Kodama et al. 2001). Since the factory workers represent about 25% of the Nagasaki survivors with DS86 doses in excess of 0.5 Gy (50 rad), systematic errors in their dose estimates can have a major impact on the risk coefficients from RERF studies. The factory worker doses may have been overestimated for a number of reasons. The calculation techniques, including the factory building modeling, weapon source spectra and cross-section data used in the DS86 shielding calculations were not detailed enough to replicate actual conditions. The models used did not take into account local shielding provided by machinery, tools, and the internal structure in the buildings. In addition, changes in the disposition of shielding following collapse of the building by the blast wave were not considered. The location of large factory complexes may be uncertain, causing large numbers of factory survivors, correctly located relative to each other, to be uniformly too close to the hypocenter. Any or all of these reasons are sufficient to result in an overestimate of the factory worker doses. During the DS02 studies, factory worker doses have been reassessed by more carefully modeling the factory buildings, incorporating improved radiation transport methods and cross-section data and using the most recent bomb leakage spectra (Chapter 2). Two-dimensional discrete ordinates calculations were carried out initially to estimate the effects of workbenches and tools on worker doses to determine if the inclusion of these components would, in fact, reduce the dose by amounts consistent with the RERF observations (Kodama et al. 2001). (author)

  10. Structural basis for phosphatidylinositol-phosphate biosynthesis

    Science.gov (United States)

    Clarke, Oliver B.; Tomasek, David; Jorge, Carla D.; Dufrisne, Meagan Belcher; Kim, Minah; Banerjee, Surajit; Rajashankar, Kanagalaghatta R.; Shapiro, Lawrence; Hendrickson, Wayne A.; Santos, Helena; Mancia, Filippo

    2015-10-01

    Phosphatidylinositol is critical for intracellular signalling and anchoring of carbohydrates and proteins to outer cellular membranes. The defining step in phosphatidylinositol biosynthesis is catalysed by CDP-alcohol phosphotransferases, transmembrane enzymes that use CDP-diacylglycerol as donor substrate for this reaction, and either inositol in eukaryotes or inositol phosphate in prokaryotes as the acceptor alcohol. Here we report the structures of a related enzyme, the phosphatidylinositol-phosphate synthase from Renibacterium salmoninarum, with and without bound CDP-diacylglycerol to 3.6 and 2.5 Å resolution, respectively. These structures reveal the location of the acceptor site, and the molecular determinants of substrate specificity and catalysis. Functional characterization of the 40%-identical ortholog from Mycobacterium tuberculosis, a potential target for the development of novel anti-tuberculosis drugs, supports the proposed mechanism of substrate binding and catalysis. This work therefore provides a structural and functional framework to understand the mechanism of phosphatidylinositol-phosphate biosynthesis.

  11. Occurrence and biosynthesis of carotenoids in phytoplankton.

    Science.gov (United States)

    Huang, Jim Junhui; Lin, Shaoling; Xu, Wenwen; Cheung, Peter Chi Keung

    2017-09-01

    Naturally occurring carotenoids are important sources of antioxidants, anti-cancer compounds and anti-inflammatory agents and there is thus considerable market demand for their pharmaceutical applications. Carotenoids are widely distributed in marine and freshwater organisms including microalgae, phytoplankton, crustaceans and fish, as well as in terrestrial plants and birds. Recently, phytoplankton-derived carotenoids have received much attention due to their abundance, rapid rate of biosynthesis and unique composition. The carotenoids that accumulate in particular phytoplankton phyla are synthesized by specific enzymes and play unique physiological roles. This review focuses on studies related to the occurrence of carotenoids in different phytoplankton phyla and the molecular aspects of their biosynthesis. Recent biotechnological advances in the isolation and characterization of some representative carotenoid synthases in phytoplankton are also discussed. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Microbial biosynthesis of nontoxic gold nanoparticles

    International Nuclear Information System (INIS)

    Roy, Swarup; Das, Tapan Kumar; Maiti, Guru Prasad; Basu, Utpal

    2016-01-01

    Graphical abstract: The manuscript deals with the fungus mediated optimized biologically synthesized GNPs using Aspergillus foetidus and characterization of biosynthesized GNPs using various physico-chemical methods. The fairly stable synthesized nanoparticles have size in the range of 10–40 nm. Cytotoxicity study of biosynthesized GNPs on Human lung cancer cell line A549 showed no significant toxicity of GNPs. - Highlights: • A novel biosynthesis process of GNPs using Aspergillus foetidus. • Biosynthesized GNPs are in the range of 10–40 nm as observed from TEM. • This process of synthesis is an optimized biosynthesis process of GNPs. • Biosynthesized GNPs are noncytotoxic against A549 cell line. - Abstract: We study the extracellular biosynthesis of gold nanoparticles (GNPs) using the fungal species Aspergillus foetidus. The formation of GNPs were initially monitored by visual observation and then characterized with the help of various characterization techniques. X-ray diffraction (XRD) results revealed distinctive formation of face centered cubic crystalline GNPs. From field emission scanning electron microscopy (FESEM) the morphology of the nanoparticles were found to be roughly spherical and within the size range of 30–50 nm. The spherical and polydispersed GNPs in the range of 10–40 nm were observed by transmission electron microscopy (TEM) analysis. It was established that alkaline pH, 1 mM gold salt concentration and 75 °C temperature were the respective optimum parameter for biosynthesis of GNPs. Cell cytotoxicity of GNP was compared with that of normal gold salt solution on A549 cell. The A549 cell growth in presence of GNPs was found to be comparatively less toxic than the gold ion.

  13. Microbial biosynthesis of nontoxic gold nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Roy, Swarup, E-mail: swaruproy@klyuniv.ac.in [Department of Biochemistry and Biophysics, University of Kalyani, Kalyani 741235, West Bengal (India); Das, Tapan Kumar [Department of Biochemistry and Biophysics, University of Kalyani, Kalyani 741235, West Bengal (India); Maiti, Guru Prasad [Department of Molecular Biology and Biotechnology, University of Kalyani, Kalyani 741235, West Bengal (India); Department of Anesthesiology, Texas Tech University Health science Center, 3601 4th Street, Lubbock, TX 79430 (United States); Basu, Utpal [Department of Molecular Biology and Biotechnology, University of Kalyani, Kalyani 741235, West Bengal (India)

    2016-01-15

    Graphical abstract: The manuscript deals with the fungus mediated optimized biologically synthesized GNPs using Aspergillus foetidus and characterization of biosynthesized GNPs using various physico-chemical methods. The fairly stable synthesized nanoparticles have size in the range of 10–40 nm. Cytotoxicity study of biosynthesized GNPs on Human lung cancer cell line A549 showed no significant toxicity of GNPs. - Highlights: • A novel biosynthesis process of GNPs using Aspergillus foetidus. • Biosynthesized GNPs are in the range of 10–40 nm as observed from TEM. • This process of synthesis is an optimized biosynthesis process of GNPs. • Biosynthesized GNPs are noncytotoxic against A549 cell line. - Abstract: We study the extracellular biosynthesis of gold nanoparticles (GNPs) using the fungal species Aspergillus foetidus. The formation of GNPs were initially monitored by visual observation and then characterized with the help of various characterization techniques. X-ray diffraction (XRD) results revealed distinctive formation of face centered cubic crystalline GNPs. From field emission scanning electron microscopy (FESEM) the morphology of the nanoparticles were found to be roughly spherical and within the size range of 30–50 nm. The spherical and polydispersed GNPs in the range of 10–40 nm were observed by transmission electron microscopy (TEM) analysis. It was established that alkaline pH, 1 mM gold salt concentration and 75 °C temperature were the respective optimum parameter for biosynthesis of GNPs. Cell cytotoxicity of GNP was compared with that of normal gold salt solution on A549 cell. The A549 cell growth in presence of GNPs was found to be comparatively less toxic than the gold ion.

  14. Make your company a talent factory.

    Science.gov (United States)

    Ready, Douglas A; Conger, Jay A

    2007-06-01

    Despite the great sums of money companies dedicate to talent management systems, many still struggle to fill key positions - limiting their potential for growth in the process. Virtually all the human resource executives in the authors' 2005 survey of 40 companies around the world said that their pipeline of high-potential employees was insufficient to fill strategic management roles. The survey revealed two primary reasons for this. First, the formal procedures for identifying and developing next-generation leaders have fallen out of sync with what companies need to grow or expand into new markets. To save money, for example, some firms have eliminated positions that would expose high-potential employees to a broad range of problems, thus sacrificing future development opportunities that would far outweigh any initial savings from the job cuts. Second, HR executives often have trouble keeping top leaders' attention on talent issues, despite those leaders' vigorous assertions that obtaining and keeping the best people is a major priority. If passion for that objective doesn't start at the top and infuse the culture, say the authors, talent management can easily deteriorate into the management of bureaucratic routines. Yet there are companies that can face the future with confidence. These firms don't just manage talent, they build talent factories. The authors describe the experiences of two such corporations - consumer products icon Procter & Gamble and financial services giant HSBC Group -that figured out how to develop and retain key employees and fill positions quickly to meet evolving business needs. Though each company approached talent management from a different direction, they both maintained a twin focus on functionality (rigorous talent processes that support strategic and cultural objectives) and vitality (management's emotional commitment, which is reflected in daily actions).

  15. The Experiment Factory: standardizing behavioral experiments

    Directory of Open Access Journals (Sweden)

    Vanessa V Sochat

    2016-04-01

    Full Text Available The administration of behavioral and experimental paradigms for psychology research is hindered by lack of a coordinated effort to develop and deploy standardized paradigms. While several frameworks (de Leeuw (2015; McDonnell et al. (2012; Mason and Suri (2011; Lange et al. (2015 have provided infrastructure and methods for individual research groups to develop paradigms, missing is a coordinated effort to develop paradigms linked with a system to easily deploy them. This disorganization leads to redundancy in development, divergent implementations of conceptually identical tasks, disorganized and error-prone code lacking documentation, and difficulty in replication. The ongoing reproducibility crisis in psychology and neuroscience research (Baker (2015; Open Science Collaboration (2015 highlights the urgency of this challenge: reproducible research in behavioral psychology is conditional on deployment of equivalent experiments. A large, accessible repository of experiments for researchers to develop collaboratively is most efficiently accomplished through an open source framework. Here we present the Experiment Factory, an open source framework for the development and deployment of web-based experiments. The modular infrastructure includes experiments, virtual machines for local or cloud deployment, and an application to drive these components and provide developers with functions and tools for further extension. We release this infrastructure with a deployment (http://www.expfactory.org that researchers are currently using to run a set of over 80 standardized web-based experiments on Amazon Mechanical Turk. By providing open source tools for both deployment and development, this novel infrastructure holds promise to bring reproducibility to the administration of experiments, and accelerate scientific progress by providing a shared community resource of psychological paradigms.

  16. Overview of the nearby supernova factory

    International Nuclear Information System (INIS)

    Aldering, Greg; Adam, Gilles; Antilogus, Pierre; Astier, Pierre; Bacon, Roland; Bongard, S.; Bonnaud, C.; Copin, Yannick; Hardin, D.; Howell, D. Andy; Lemmonnier, Jean-Pierre; Levy, J.-M.; Loken, S.; Nugent, Peter; Pain, Reynald; Pecontal, Arlette; Pecontal, Emmanuel; Perlmutter, Saul; Quimby, Robert; Schahmaneche, Kyan; Smadja, Gerard; Wood-Vasey, W. Michael

    2002-01-01

    The Nearby Supernova Factory (SNfactory) is an international experiment designed to lay the foundation for the next generation of cosmology experiments (such as CFHTLS, wP, SNAP and LSST) which will measure the expansion history of the Universe using Type Ia supernovae. The SNfactory will discover and obtain frequent lightcurve spectrophotometry covering 3200-10000 (angstrom) for roughly 300 Type Ia supernovae at the loW--redshift end of the smooth Hubble flow. The quantity, quality, breadth of galactic environments, and homogeneous nature of the SNfactory dataset will make it the premier source of calibration for the Type Ia supernova width-brightness relation and the intrinsic supernova colors used for K-correction and correction for extinction by host-galaxy dust. This dataset will also allow an extensive investigation of additional parameters which possibly influence the quality of Type Ia supernovae as cosmological probes. The SNfactory search capabilities and folloW--up instrumentation include wide-field CCD imagers on two 1.2-m telescopes (via collaboration with the Near Earth Asteroid Tracking team at JPL and the QUEST team at Yale), and a two-channel integral-field-unit optical spectrograph/imager being fabricated for the University of Hawaii 2.2-m telescope. In addition to ground-based folloW--up, UV spectra for a subsample of these supernovae will be obtained with HST. The pipeline to obtain, transfer via wireless and standard internet, and automatically process the search images is in operation. Software and hardware development is now underway to enable the execution of folloW--up spectroscopy of supernova candidates at the Hawaii 2.2-m telescope via automated remote control of the telescope and the IFU spectrograph/imager

  17. PEP-II: An asymmetric B factory

    International Nuclear Information System (INIS)

    1993-06-01

    In this report, the authors have described an updated conceptual design for the high-luminosity Asymmetric B Factory (PEP-II) to be built in the PEP tunnel culmination of more than four years of effort aimed at the design and construction of an asymmetric e + e - collider capable of achieving a luminosity of L = 3 x 10 33 cm -2 s -1 . All aspects of the conceptual design were scrutinized in March 1991 by a DOE technical review committee chaired by Dr. L. Edward Temple. The design was deemed feasible and capable of achieving its physics goals. Furthermore, the cost estimate, schedule, and management plan for the project were fully endorsed by the committee. This updated conceptual design report captures the technical progress since the March 1991 review and reflects the lower cost estimate corresponding to the improved design. Although the PEP-II design has continued to evolve, no technical scope changes have been made that invalidate the conclusion of the DOE review. The configuration adopted utilizes two storage rings, an electron ring operating at 9 GeV and a positron ring at 3.1 GeV, each with a circumference of 2200 m. The high-energy ring is an upgrade of the PEP storage ring at SLAC; all PEP magnets and most power supplies will be reused. The upgrade consists primarily of replacing the PEP vacuum chamber and RF system with newly designed versions optimized for the high-current environment of PEP-II. The low-energy ring will be newly constructed and will be situated atop the high-energy ring in the PEP tunnel. Utilities already installed in the PEP tunnel are largely sufficient to operate the two PEP-II storage rings

  18. Neutrino Factory Accelerator R and D: Status and Priorities

    International Nuclear Information System (INIS)

    Zisman, Michael S.

    2005-01-01

    This paper summarizes the status of worldwide Neutrino Factory R and D efforts. Activities are categorized as simulations, component development, and system tests. An indication of R and D tasks that remain to be accomplished is also given

  19. Training Workers for the Factory of the Future.

    Science.gov (United States)

    Clancy, J. Anthony

    1989-01-01

    In the factory of the future, emphasis on quality and increased productivity creates a competitive advantage. People and computers work together in all major activities. Training is a major factor in creating that competitive advantage. (JOW)

  20. Three-dimensional structure of Rubella virus factories

    International Nuclear Information System (INIS)

    Fontana, Juan; Lopez-Iglesias, Carmen; Tzeng, Wen-Ping; Frey, Teryl K.; Fernandez, Jose J.; Risco, Cristina

    2010-01-01

    Viral factories are complex structures in the infected cell where viruses compartmentalize their life cycle. Rubella virus (RUBV) assembles factories by recruitment of rough endoplasmic reticulum (RER), mitochondria and Golgi around modified lysosomes known as cytopathic vacuoles or CPVs. These organelles contain active replication complexes that transfer replicated RNA to assembly sites in Golgi membranes. We have studied the structure of RUBV factory in three dimensions by electron tomography and freeze-fracture. CPVs contain stacked membranes, rigid sheets, small vesicles and large vacuoles. These membranes are interconnected and in communication with the endocytic pathway since they incorporate endocytosed BSA-gold. RER and CPVs are coupled through protein bridges and closely apposed membranes. Golgi vesicles attach to the CPVs but no tight contacts with mitochondria were detected. Immunogold labelling confirmed that the mitochondrial protein p32 is an abundant component around and inside CPVs where it could play important roles in factory activities.

  1. PARTICLE FACTORIES: Tau-charm in the spotlight

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1991-07-15

    Following earlier workshops in Stanford (1989) and in Orsay (1990), some hundred physicists from Europe and the United States met from 29 April to 2 May in Seville, Spain, to consolidate plans for a Tau-Charm Factory.

  2. Measurement of CP violation at a Neutrino Factory

    CERN Document Server

    Gómez-Cadenas, J J

    2001-01-01

    The prospects of measuring CP violation in the leptonic sector using the intense neutrino beams arising from muon decay in the straight sections of a muon accumulator ring (the so-called neutrino factory) are discussed.

  3. Argonne Tau-charm factory collider design study

    International Nuclear Information System (INIS)

    Teng, L.C.; Crosbie, E.A.; Norem, J.

    1995-01-01

    The design approach and design principles for a Tau-charm Factory at Argonne were studied. These studies led to a set of preliminary parameters and tentative component features as presented in this paper

  4. PARTICLE FACTORIES: Tau-charm in the spotlight

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    Following earlier workshops in Stanford (1989) and in Orsay (1990), some hundred physicists from Europe and the United States met from 29 April to 2 May in Seville, Spain, to consolidate plans for a Tau-Charm Factory

  5. Review of Hosein Aabad Sugar Factory (HASF) Wastewater and ...

    African Journals Online (AJOL)

    MICHAEL HORSFALL

    evaluate the quality and quantity of wastewater of the said factory and to estimate the pollution ... appropriate for artificial recharge use, discharge in rivers and lakes or utilization in agriculture ..... These problems have a negative impact on.

  6. Fluorine in plants in the areas of Yugoslav aluminum factories

    Energy Technology Data Exchange (ETDEWEB)

    Ivos, J.; Ciszek, H.; Rezek, A.; Marjanovic, L.

    1970-01-01

    Distribution of fluorine in the areas around aluminum production facilities was investigated. The plants in areas around the factories did indeed show increased levels of fluorine. Distribution patterns were found to be affected by wind and precipitation patterns.

  7. Architectural design of experience based factory model for software ...

    African Journals Online (AJOL)

    architectural design. Automation features are incorporated in the design in which workflow system and intelligent agents are integrated, and the facilitation of cloud environment is empowered to further support the automation. Keywords: architectural design; knowledge management; experience factory; workflow;

  8. Argonne Tau-charm Factory collider design study

    International Nuclear Information System (INIS)

    Teng, L.C.; Crosbie, E.A.; Norem, J.; Repond, J.

    1996-01-01

    The design approach and design principles for a Tau-charm Factory at Argonne were studied. These studies led to a set of preliminary parameters and tentative component features as presented in this paper. copyright 1996 American Institute of Physics

  9. Mainz/PSI φ-factory design considerations

    International Nuclear Information System (INIS)

    Streun, A.

    1991-01-01

    Design considerations for a φ-factory with a Luminosity of the order of 10 33 cm -2 s -1 lead to the concept of a multi-bunch round beam double storage ring with superconducting solenoids for micro-beta focusing and beam rotation. Simulations of the beam-beam-interaction indicate, that significantly higher beam-beam-parameters may become possible with round beams. A rough draft design of a round beam φ-factory is presented. (orig.)

  10. Synchronous method and engineering tool for the strategic factory planning

    OpenAIRE

    Abdul Rahman, O.; Jaeger, J.; Constantinescu, C.

    2011-01-01

    This paper presents the approach to combine two reference methods and engineering tools, for "Factory Performance and Investment Planning«as well as "Value Added Ideal Production Network Planning". The resulted synchronous method aims to support factories in the strategic planning as well as in the network planning. The corresponding engineering tool is employed for assessment planning, sales planning, capacity planning and production costs planning under the consideration of dynamic and stoc...

  11. Russian factory inspection (1882-1918): cui bono?

    OpenAIRE

    Volodin , Andrei Y.

    2008-01-01

    This study deals with history of important state institution in late Russian Empire - factory inspection. Such aspects of institutional development as evolution of legislative regulations, growth of staff, and complication of functions (and particularly, mediation in labour conflicts) are scrutinized. This paper presents some results on Russian experience of labour law implementation seeking to determine and evaluate the role and efficiency of Russian factory inspectors in conflicting triangl...

  12. Development of Rotational Smart Lighting Control System for Plant Factory

    OpenAIRE

    Won-Sub Lee; Sung-Gaun Kim

    2012-01-01

    Rotational Smart Lighting Control System can supply the quantity of lighting which is required to run plants by rotating few LED and Fluorescent instead of that are used in the existing plant factories.The initial installation of the existing plants factory is expensive, so in order to solve the problem with smart lighting control system was developed. The beam required intensity for the growth of crops, Photosynthetic Photon Flux Density(PPFD)is calculated; and the numbe...

  13. Factorial moment and fractal analysis of γ families

    International Nuclear Information System (INIS)

    Kalmakhelidze, M.Eh.; Roinishvili, N.N.; Svanidze, M.S.; Khizanishvili, L.A.; Chadranyan, L.Kh.

    1997-01-01

    Factorial and fractal methods were applied to nuclear-electromagnetic cascades in the atmosphere (γ families) to find sensitivity of these methods to multiparticle fluctuations in γ families. Averaged parameters of factorial and fractal methods of the real families were compared with the same quantities for the statistical set of random families. The correlations between the same parameters for families divided into sectors and into rings are studied. The correlations between different parameters for the same families divided into sectors are investigated

  14. Virtual Factory Framework for Supporting Production Planning and Control.

    Science.gov (United States)

    Kibira, Deogratias; Shao, Guodong

    2017-01-01

    Developing optimal production plans for smart manufacturing systems is challenging because shop floor events change dynamically. A virtual factory incorporating engineering tools, simulation, and optimization generates and communicates performance data to guide wise decision making for different control levels. This paper describes such a platform specifically for production planning. We also discuss verification and validation of the constituent models. A case study of a machine shop is used to demonstrate data generation for production planning in a virtual factory.

  15. INDOOR THERMAL CONDITION OF FACTORY BUILDING IN BANGLADESH

    Directory of Open Access Journals (Sweden)

    Muhammed Abdullah Al Sayem Khan

    2011-12-01

    Full Text Available Bangladesh is a developing country and has a lot of factories for different products for local use and also export to abroad. Garments industries are one of the top most items of exported items. A huge number of populations are working in garments industries. But these factories are not well designed in sense of the thermal environment. Workers experiences sickness related to indoor environment. The productions of these factories are affected due to employees’ health condition. The research is done in two different methods. One is empirical data collection using thermal data loggers and the other is questionnaire survey on the spots for three factory buildings. The field study was conducted in four different months of the same year during winter and summer period. Expected findings of this research are that the indoor environment is not comfortable for works at day time during summer season. This research will help the factory workers in providing a comfortable thermal environment and also help the employers or factory owners to increase their production margin.

  16. Implementing Clinical Research Using Factorial Designs: A Primer.

    Science.gov (United States)

    Baker, Timothy B; Smith, Stevens S; Bolt, Daniel M; Loh, Wei-Yin; Mermelstein, Robin; Fiore, Michael C; Piper, Megan E; Collins, Linda M

    2017-07-01

    Factorial experiments have rarely been used in the development or evaluation of clinical interventions. However, factorial designs offer advantages over randomized controlled trial designs, the latter being much more frequently used in such research. Factorial designs are highly efficient (permitting evaluation of multiple intervention components with good statistical power) and present the opportunity to detect interactions amongst intervention components. Such advantages have led methodologists to advocate for the greater use of factorial designs in research on clinical interventions (Collins, Dziak, & Li, 2009). However, researchers considering the use of such designs in clinical research face a series of choices that have consequential implications for the interpretability and value of the experimental results. These choices include: whether to use a factorial design, selection of the number and type of factors to include, how to address the compatibility of the different factors included, whether and how to avoid confounds between the type and number of interventions a participant receives, and how to interpret interactions. The use of factorial designs in clinical intervention research poses choices that differ from those typically considered in randomized clinical trial designs. However, the great information yield of the former encourages clinical researchers' increased and careful execution of such designs. Copyright © 2017. Published by Elsevier Ltd.

  17. Black hole as a wormhole factory

    Directory of Open Access Journals (Sweden)

    Sung-Won Kim

    2015-12-01

    Full Text Available There have been lots of debates about the final fate of an evaporating black hole and the singularity hidden by an event horizon in quantum gravity. However, on general grounds, one may argue that a black hole stops radiation at the Planck mass (ħc/G1/2∼10−5 g, where the radiated energy is comparable to the black hole's mass. And also, it has been argued that there would be a wormhole-like structure, known as “spacetime foam”, due to large fluctuations below the Planck length (ħG/c31/2∼10−33 cm. In this paper, as an explicit example, we consider an exact classical solution which represents nicely those two properties in a recently proposed quantum gravity model based on different scaling dimensions between space and time coordinates. The solution, called “Black Wormhole”, consists of two different states, depending on its mass parameter M and an IR parameter ω: For the black hole state (with ωM2>1/2, a non-traversable wormhole occupies the interior region of the black hole around the singularity at the origin, whereas for the wormhole state (with ωM2<1/2, the interior wormhole is exposed to an outside observer as the black hole horizon is disappearing from evaporation. The black hole state becomes thermodynamically stable as it approaches the merging point where the interior wormhole throat and the black hole horizon merges, and the Hawking temperature vanishes at the exact merge point (with ωM2=1/2. This solution suggests the “Generalized Cosmic Censorship” by the existence of a wormhole-like structure which protects the naked singularity even after the black hole evaporation. One could understand the would-be wormhole inside the black hole horizon as the result of microscopic wormholes created by “negative” energy quanta which have entered the black hole horizon in Hawking radiation process; the quantum black hole could be a wormhole factory! It is found that this speculative picture may be consistent with the

  18. Measurement of Air Pollution Comes from Adra Cement Factory

    International Nuclear Information System (INIS)

    Odat, M.; Meslmani, Y.; Al-Kharfan, K.; Shamali, K.

    2013-06-01

    Measurements of air pollution were carried out in and around Adra cement factory during a single period (December). The Measurements included the following: 1- Dust fall. 2- Total suspended particulates (TSP) and inhalable particulates PM-1-0 & PM-3 inside the factor and in residential area surrounded the factory (Worker City of Adra, Adra city, Wafeden Mokheam, Baironi Hospital and Alkatiefa City). 3-Determination the levels of Cd, Pb, Cu and zinc associated with air born. 4- Determination of toxic gases (CO, SO-2 and NO-x) emitted from the chimneys. The results showed that the quantity of dust fall was varied obviously inside the factory and the regions affected by air pollutions. The monthly concentration of dust fall were 165, 27 and 10 tons/Km 2 /month inside the factory , affected villages and Baironi Hospital respectively, Wherein the permissible limit is (9tons/Km'2/month). The total suspended particulates (TSP) and inhalable particulates PM-1-0 & PM-3 in the studies area were higher than the permissible limit. The TSP concentrations inside the factory ranged between 497 and 2021 microgram/m'3 while the ranged between 328 and 561 microgram /m'3 in the surrounded villages and between 232 and 244 microgram/m'3 near Damascus, the were far higher than the world health organization (WHO) standards (120 Microgram/m'3). The PM-3 which is the most effecting on the human health reached 117.6, 124.6 and 62.6 microgram /m 3 inside the factory (main in trance), city worker of Adra and Baironi Hospital respectively, theses concentrations were higher than the Syrian standards (15 microgram/m'3) The measurements which were carried out through an exclusive day refered that the percentage of TSP/PM-3 is increasedwith moving away from the factory and reached 6.8, 18.6, 19.3% in the main intrance of the factory, worker city of Adra and Bironi Hospital respectively. The level of toxic gases inside the source (chimneys) was within the standards

  19. Heme biosynthesis and its regulation : Toward understanding and improvement of heme biosynthesis in filamentous fungi.

    NARCIS (Netherlands)

    S. de Weert; P.J. Punt; Christien Lokman; C.A. van den Hondel; A.C. Franken; A.F. Ram

    2011-01-01

    Heme biosynthesis in fungal host strains has acquired considerable interest in relation to the production of secreted heme-containing peroxidases. Class II peroxidase enzymes have been suggested as eco-friendly replacements of polluting chemical processes in industry. These peroxidases are naturally

  20. Heme biosynthesis and its regulation: Towards understanding and improvement of heme biosynthesis in filamentous fungi

    NARCIS (Netherlands)

    Franken, A.C.W.; Lokman, B.C.; Ram, A.F.J.; Punt, P.J.; Hondel, C.A.M.J.J. van den; Weert, S. de

    2011-01-01

    Heme biosynthesis in fungal host strains has acquired considerable interest in relation to the production of secreted heme-containing peroxidases. Class II peroxidase enzymes have been suggested as eco-friendly replacements of polluting chemical processes in industry. These peroxidases are naturally

  1. Biosynthesis of Gold Nanoparticles Using Pseudomonas Aeruginosa

    International Nuclear Information System (INIS)

    Abd El-Aziz, M.; Badr, Y.; Mahmoud, M. A.

    2007-01-01

    Pseudomonas aeruginosa were used for extracellular biosynthesis of gold nanoparticles (Au NPs). Consequently, Au NPs were formed due to reduction of gold ion by bacterial cell supernatant of P. aeruginos ATCC 90271, P. aeruginos (2) and P. aeruginos (1). The UV-Vis. and fluorescence spectra of the bacterial as well as chemical prepared Au NPs were recorded. Transmission electron microscopy (TEM) micrograph showed the formation of well-dispersed gold nanoparticles in the range of 15-30 nm. The process of reduction being extracellular and may lead to the development of an easy bioprocess for synthesis of Au NPs

  2. Wybutosine biosynthesis: Structural and mechanistic overview

    Science.gov (United States)

    Perche-Letuvée, Phanélie; Molle, Thibaut; Forouhar, Farhad; Mulliez, Etienne; Atta, Mohamed

    2014-01-01

    Over the last 10 years, significant progress has been made in understanding the genetics, enzymology and structural components of the wybutosine (yW) biosynthetic pathway. These studies have played a key role in expanding our understanding of yW biosynthesis and have revealed unexpected evolutionary ties, which are presently being unraveled. The enzymes catalyzing the 5 steps of this pathway, from genetically encoded guanosine to wybutosine base, provide an ensemble of amazing reaction mechanisms that are to be discussed in this review article. PMID:25629788

  3. Chemical Elicitors of Antibiotic Biosynthesis in Actinomycetes

    Directory of Open Access Journals (Sweden)

    Anton P. Tyurin

    2018-06-01

    Full Text Available Whole genome sequencing of actinomycetes has uncovered a new immense realm of microbial chemistry and biology. Most biosynthetic gene clusters present in genomes were found to remain “silent” under standard cultivation conditions. Some small molecules—chemical elicitors—can be used to induce the biosynthesis of antibiotics in actinobacteria and to expand the chemical diversity of secondary metabolites. Here, we outline a brief account of the basic principles of the search for regulators of this type and their application.

  4. DEVELOPMENT OF LAW RELATING TO FACTORIES IN INDIA

    Directory of Open Access Journals (Sweden)

    M. K. Sahu

    2015-01-01

    Full Text Available The rapid growth of industrial town and factories has paved the way to develop our industrial legislation accordingly. The Government of India never expressed their interest in framing separate legislation vis-à-vis factories which resulted in implementation of the same statute which was enacted pre-independence. It was done by virtue of Art. 372 of the Constitution of India. However, the Constitutional Lawmakers created vacuum for the implementation of new statute in accordance with the demand of society by inserting scope under the Directive Principles of State Policies. However, in the 67 years history of Indian Republic, there are unprecedented developments of law relating to factories in India.The Government of India, with the adoption of existed statute, made an effort to incorporate the welfare legislation but it never developed along with the change in time. It is to be noticed that as far as existing statutes are concerned, the development is an effect of judicial pronouncement or some tragic incident like Bhopal Gas Tragedy. This paper succinctly describes the history of factory legislation, the constitutional validity of the previous statute and necessary amendment which have already been done and / or on the verge of being amended. It will further discuss contribution of judiciary in developing the law relating to factories, scope of industrial jurisprudence in promoting the development of factory legislation. The primary focus of the research project is to reflect upon the areas where factory legislation has developed, so that proper yardstick could be made in order to put emphasis on those areas which have been remained untouched.

  5. Design, analysis and presentation of factorial randomised controlled trials

    Directory of Open Access Journals (Sweden)

    Little Paul

    2003-11-01

    Full Text Available Abstract Background The evaluation of more than one intervention in the same randomised controlled trial can be achieved using a parallel group design. However this requires increased sample size and can be inefficient, especially if there is also interest in considering combinations of the interventions. An alternative may be a factorial trial, where for two interventions participants are allocated to receive neither intervention, one or the other, or both. Factorial trials require special considerations, however, particularly at the design and analysis stages. Discussion Using a 2 × 2 factorial trial as an example, we present a number of issues that should be considered when planning a factorial trial. The main design issue is that of sample size. Factorial trials are most often powered to detect the main effects of interventions, since adequate power to detect plausible interactions requires greatly increased sample sizes. The main analytical issues relate to the investigation of main effects and the interaction between the interventions in appropriate regression models. Presentation of results should reflect the analytical strategy with an emphasis on the principal research questions. We also give an example of how baseline and follow-up data should be presented. Lastly, we discuss the implications of the design, analytical and presentational issues covered. Summary Difficulties in interpreting the results of factorial trials if an influential interaction is observed is the cost of the potential for efficient, simultaneous consideration of two or more interventions. Factorial trials can in principle be designed to have adequate power to detect realistic interactions, and in any case they are the only design that allows such effects to be investigated.

  6. Monoterpene biosynthesis potential of plant subcellular compartments.

    Science.gov (United States)

    Dong, Lemeng; Jongedijk, Esmer; Bouwmeester, Harro; Van Der Krol, Alexander

    2016-01-01

    Subcellular monoterpene biosynthesis capacity based on local geranyl diphosphate (GDP) availability or locally boosted GDP production was determined for plastids, cytosol and mitochondria. A geraniol synthase (GES) was targeted to plastids, cytosol, or mitochondria. Transient expression in Nicotiana benthamiana indicated local GDP availability for each compartment but resulted in different product levels. A GDP synthase from Picea abies (PaGDPS1) was shown to boost GDP production. PaGDPS1 was also targeted to plastids, cytosol or mitochondria and PaGDPS1 and GES were coexpressed in all possible combinations. Geraniol and geraniol-derived products were analyzed by GC-MS and LC-MS, respectively. GES product levels were highest for plastid-targeted GES, followed by mitochondrial- and then cytosolic-targeted GES. For each compartment local boosting of GDP biosynthesis increased GES product levels. GDP exchange between compartments is not equal: while no GDP is exchanged from the cytosol to the plastids, 100% of GDP in mitochondria can be exchanged to plastids, while only 7% of GDP from plastids is available for mitochondria. This suggests a direct exchange mechanism for GDP between plastids and mitochondria. Cytosolic PaGDPS1 competes with plastidial GES activity, suggesting an effective drain of isopentenyl diphosphate from the plastids to the cytosol. © 2015 The Authors. New Phytologist © 2015 New Phytologist Trust.

  7. Fatty acid biosynthesis in pea root plastids

    International Nuclear Information System (INIS)

    Stahl, R.J.; Sparace, S.A.

    1989-01-01

    Fatty acid biosynthesis from [1- 14 C]acetate was optimized in plastids isolated from primary root tips of 7-day-old germinating pea seeds. Fatty acid synthesis was maximum at approximately 80 nmoles/hr/mg protein in the presence of 200 μM acetate, 0.5 mM each of NADH, NADPH and CoA, 6 mM each of ATP and MgCl 2 , 1 mM each of the MnCl 2 and glycerol-3-phosphate, 15 mM KHCO 3 , and 0.1M Bis-tris-propane, pH 8.0 incubated at 35C. At the standard incubation temperature of 25C, fatty acid synthesis was linear from up to 6 hours with 80 to 100 μg/mL plastid protein. ATP and CoA were absolute requirements, whereas KHCO 3 , divalent cations and reduced nucleotides all improved activity by 80 to 85%. Mg 2+ and NADH were the preferred cation and nucleotide, respectively. Dithiothreitol and detergents were generally inhibitory. The radioactive products of fatty acid biosynthesis were approximately 33% 16:0, 10% 18:0 and 56% 18:1 and generally did not vary with increasing concentrations of each cofactor

  8. Molecular Regulation of Antibiotic Biosynthesis in Streptomyces

    Science.gov (United States)

    Liu, Gang; Chandra, Govind; Niu, Guoqing

    2013-01-01

    SUMMARY Streptomycetes are the most abundant source of antibiotics. Typically, each species produces several antibiotics, with the profile being species specific. Streptomyces coelicolor, the model species, produces at least five different antibiotics. We review the regulation of antibiotic biosynthesis in S. coelicolor and other, nonmodel streptomycetes in the light of recent studies. The biosynthesis of each antibiotic is specified by a large gene cluster, usually including regulatory genes (cluster-situated regulators [CSRs]). These are the main point of connection with a plethora of generally conserved regulatory systems that monitor the organism's physiology, developmental state, population density, and environment to determine the onset and level of production of each antibiotic. Some CSRs may also be sensitive to the levels of different kinds of ligands, including products of the pathway itself, products of other antibiotic pathways in the same organism, and specialized regulatory small molecules such as gamma-butyrolactones. These interactions can result in self-reinforcing feed-forward circuitry and complex cross talk between pathways. The physiological signals and regulatory mechanisms may be of practical importance for the activation of the many cryptic secondary metabolic gene cluster pathways revealed by recent sequencing of numerous Streptomyces genomes. PMID:23471619

  9. Benzylisoquinoline alkaloid biosynthesis in opium poppy.

    Science.gov (United States)

    Beaudoin, Guillaume A W; Facchini, Peter J

    2014-07-01

    Opium poppy (Papaver somniferum) is one of the world's oldest medicinal plants and remains the only commercial source for the narcotic analgesics morphine, codeine and semi-synthetic derivatives such as oxycodone and naltrexone. The plant also produces several other benzylisoquinoline alkaloids with potent pharmacological properties including the vasodilator papaverine, the cough suppressant and potential anticancer drug noscapine and the antimicrobial agent sanguinarine. Opium poppy has served as a model system to investigate the biosynthesis of benzylisoquinoline alkaloids in plants. The application of biochemical and functional genomics has resulted in a recent surge in the discovery of biosynthetic genes involved in the formation of major benzylisoquinoline alkaloids in opium poppy. The availability of extensive biochemical genetic tools and information pertaining to benzylisoquinoline alkaloid metabolism is facilitating the study of a wide range of phenomena including the structural biology of novel catalysts, the genomic organization of biosynthetic genes, the cellular and sub-cellular localization of biosynthetic enzymes and a variety of biotechnological applications. In this review, we highlight recent developments and summarize the frontiers of knowledge regarding the biochemistry, cellular biology and biotechnology of benzylisoquinoline alkaloid biosynthesis in opium poppy.

  10. Essences in Metabolic Engineering of Lignan Biosynthesis

    Directory of Open Access Journals (Sweden)

    Honoo Satake

    2015-05-01

    Full Text Available Lignans are structurally and functionally diverse phytochemicals biosynthesized in diverse plant species and have received wide attentions as leading compounds of novel drugs for tumor treatment and healthy diets to reduce of the risks of lifestyle-related non-communicable diseases. However, the lineage-specific distribution and the low-amount of production in natural plants, some of which are endangered species, hinder the efficient and stable production of beneficial lignans. Accordingly, the development of new procedures for lignan production is of keen interest. Recent marked advances in the molecular and functional characterization of lignan biosynthetic enzymes and endogenous and exogenous factors for lignan biosynthesis have suggested new methods for the metabolic engineering of lignan biosynthesis cascades leading to the efficient, sustainable, and stable lignan production in plants, including plant cell/organ cultures. Optimization of light conditions, utilization of a wide range of elicitor treatments, and construction of transiently gene-transfected or transgenic lignan-biosynthesizing plants are mainly being attempted. This review will present the basic and latest knowledge regarding metabolic engineering of lignans based on their biosynthetic pathways and biological activities, and the perspectives in lignan production via metabolic engineering.

  11. Biosynthesis of nanoparticles using microbes- a review.

    Science.gov (United States)

    Hulkoti, Nasreen I; Taranath, T C

    2014-09-01

    The biosynthesis of nanoparticles by microorganism is a green and eco-friendly technology. This review focuses on the use of consortium of diverse microorganisms belonging to both prokaryotes and eukaryotes for the synthesis of metallic nanoparticles viz. silver, gold, platinum, zirconium, palladium, iron, cadmium and metal oxides such as titanium oxide, zinc oxide, etc. These microorganisms include bacteria, actinomycetes, fungi and algae. The synthesis of nanoparticles may be intracellular or extracellular. The several workers have reported that NADH dependent nitrate reductase enzyme plays a vital role in the conversion of metallic ions to nanoparticles. The FTIR study reveals that diverse biomolecules viz. carboxyl group, primary and secondary amines, amide I, II, and III bands etc serve as a tool for bioreduction and capping agents there by offering stability to particles by preventing agglomeration and growth. The size and shape of the nanoparticles vary with the organism employed and conditions employed during the synthesis which included pH, temperature and substrate concentration. The microorganisms provide diverse environment for biosynthesis of nanoparticles. These particles are safe and eco-friendly with a lot of applications in medicine, agriculture, cosmetic industry, drug delivery and biochemical sensors. The challenges for redressal include optimal production and minimal time to obtain desired size and shape, to enhance the stability of nanoparticles and optimization of specific microorganisms for specific application. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. Metabolic plasticity for isoprenoid biosynthesis in bacteria.

    Science.gov (United States)

    Pérez-Gil, Jordi; Rodríguez-Concepción, Manuel

    2013-05-15

    Isoprenoids are a large family of compounds synthesized by all free-living organisms. In most bacteria, the common precursors of all isoprenoids are produced by the MEP (methylerythritol 4-phosphate) pathway. The MEP pathway is absent from archaea, fungi and animals (including humans), which synthesize their isoprenoid precursors using the completely unrelated MVA (mevalonate) pathway. Because the MEP pathway is essential in most bacterial pathogens (as well as in the malaria parasites), it has been proposed as a promising new target for the development of novel anti-infective agents. However, bacteria show a remarkable plasticity for isoprenoid biosynthesis that should be taken into account when targeting this metabolic pathway for the development of new antibiotics. For example, a few bacteria use the MVA pathway instead of the MEP pathway, whereas others possess the two full pathways, and some parasitic strains lack both the MVA and the MEP pathways (probably because they obtain their isoprenoids from host cells). Moreover, alternative enzymes and metabolic intermediates to those of the canonical MVA or MEP pathways exist in some organisms. Recent work has also shown that resistance to a block of the first steps of the MEP pathway can easily be developed because several enzymes unrelated to isoprenoid biosynthesis can produce pathway intermediates upon spontaneous mutations. In the present review, we discuss the major advances in our knowledge of the biochemical toolbox exploited by bacteria to synthesize the universal precursors for their essential isoprenoids.

  13. Brassinosteroid biosynthesis and signalling in Petunia hybrida.

    Science.gov (United States)

    Verhoef, Nathalie; Yokota, Takao; Shibata, Kyomi; de Boer, Gert-Jan; Gerats, Tom; Vandenbussche, Michiel; Koes, Ronald; Souer, Erik

    2013-05-01

    Brassinosteroids (BRs) are steroidal plant hormones that play an important role in the growth and development of plants. The biosynthesis of sterols and BRs as well as the signalling cascade they induce in plants have been elucidated largely through metabolic studies and the analysis of mutants in Arabidopsis and rice. Only fragmentary details about BR signalling in other plant species are known. Here a forward genetics strategy was used in Petunia hybrida, by which 19 families with phenotypic alterations typical for BR deficiency mutants were identified. In all mutants, the endogenous BR levels were severely reduced. In seven families, the tagged genes were revealed as the petunia BR biosynthesis genes CYP90A1 and CYP85A1 and the BR receptor gene BRI1. In addition, several homologues of key regulators of the BR signalling pathway were cloned from petunia based on homology with their Arabidopsis counterparts, including the BRI1 receptor, a member of the BES1/BZR1 transcription factor family (PhBEH2), and two GSK3-like kinases (PSK8 and PSK9). PhBEH2 was shown to interact with PSK8 and 14-3-3 proteins in yeast, revealing similar interactions to those during BR signalling in Arabidopsis. Interestingly, PhBEH2 also interacted with proteins implicated in other signalling pathways. This suggests that PhBEH2 might function as an important hub in the cross-talk between diverse signalling pathways.

  14. BIOSYNTHESIS AND ACTION OF JASMONATES IN PLANTS.

    Science.gov (United States)

    Creelman, Robert A.; Mullet, John E.

    1997-06-01

    Jasmonic acid and its derivatives can modulate aspects of fruit ripening, production of viable pollen, root growth, tendril coiling, and plant resistance to insects and pathogens. Jasmonate activates genes involved in pathogen and insect resistance, and genes encoding vegetative storage proteins, but represses genes encoding proteins involved in photosynthesis. Jasmonic acid is derived from linolenic acid, and most of the enzymes in the biosynthetic pathway have been extensively characterized. Modulation of lipoxygenase and allene oxide synthase gene expression in transgenic plants raises new questions about the compartmentation of the biosynthetic pathway and its regulation. The activation of jasmonic acid biosynthesis by cell wall elicitors, the peptide systemin, and other compounds will be related to the function of jasmonates in plants. Jasmonate modulates gene expression at the level of translation, RNA processing, and transcription. Promoter elements that mediate responses to jasmonate have been isolated. This review covers recent advances in our understanding of how jasmonate biosynthesis is regulated and relates this information to knowledge of jasmonate modulated gene expression.

  15. Incense and Joss Stick Making in Small Household Factories, Thailand

    Directory of Open Access Journals (Sweden)

    S Siripanich

    2014-07-01

    Full Text Available Background: Incense and joss stick are generally used in the world. Most products were made in small household factories. There are many environmental and occupational hazards in these factories. Objective: To evaluate the workplace environmental and occupational hazards in small household incense and joss stick factories in Roi-Et, Thailand. Methods: Nine small household factories in rural areas of Roi-Et, Thailand, were studied. Dust concentration and small aerosol particles were counted through real time exposure monitoring. The inductively coupled plasma optical emission spectrometry (ICP-OES was used for quantitative measurement of heavy metal residue in incense products. Results: Several heavy metals were found in dissolved dye and joss sticks. Those included barium, manganese, and lead. Rolling and shaking processes produced the highest concentration of dust and aerosols. Only 3.9 % of female workers used personal protection equipment. Conclusion: Dust and chemicals were major threats in small household incense and joss stick factories in Thailand. Increasing awareness towards using personal protection equipment and emphasis on elimination of environmental workplace hazards should be considered to help the workers of this industry.

  16. SYSTEMS BIOLOGY AND METABOLIC ENGINEERING OF ARTHROSPIRA CELL FACTORIES

    Directory of Open Access Journals (Sweden)

    Amornpan Klanchui

    2012-10-01

    Full Text Available Arthrospira are attractive candidates to serve as cell factories for production of many valuable compounds useful for food, feed, fuel and pharmaceutical industries. In connection with the development of sustainable bioprocessing, it is a challenge to design and develop efficient Arthrospira cell factories which can certify effective conversion from the raw materials (i.e. CO2 and sun light into desired products. With the current availability of the genome sequences and metabolic models of Arthrospira, the development of Arthrospira factories can now be accelerated by means of systems biology and the metabolic engineering approach. Here, we review recent research involving the use of Arthrospira cell factories for industrial applications, as well as the exploitation of systems biology and the metabolic engineering approach for studying Arthrospira. The current status of genomics and proteomics through the development of the genome-scale metabolic model of Arthrospira, as well as the use of mathematical modeling to simulate the phenotypes resulting from the different metabolic engineering strategies are discussed. At the end, the perspective and future direction on Arthrospira cell factories for industrial biotechnology are presented.

  17. Operating a production pilot factory serving several scientific domains

    Science.gov (United States)

    Sfiligoi, I.; Würthwein, F.; Andrews, W.; Dost, J. M.; MacNeill, I.; McCrea, A.; Sheripon, E.; Murphy, C. W.

    2011-12-01

    Pilot infrastructures are becoming prominent players in the Grid environment. One of the major advantages is represented by the reduced effort required by the user communities (also known as Virtual Organizations or VOs) due to the outsourcing of the Grid interfacing services, i.e. the pilot factory, to Grid experts. One such pilot factory, based on the glideinWMS pilot infrastructure, is being operated by the Open Science Grid at University of California San Diego (UCSD). This pilot factory is serving multiple VOs from several scientific domains. Currently the three major clients are the analysis operations of the HEP experiment CMS, the community VO HCC, which serves mostly math, biology and computer science users, and the structural biology VO NEBioGrid. The UCSD glidein factory allows the served VOs to use Grid resources distributed over 150 sites in North and South America, in Europe, and in Asia. This paper presents the steps taken to create a production quality pilot factory, together with the challenges encountered along the road.

  18. Operating a production pilot factory serving several scientific domains

    International Nuclear Information System (INIS)

    Sfiligoi, I; Würthwein, F; Andrews, W; Dost, J M; MacNeill, I; McCrea, A; Sheripon, E; Murphy, C W

    2011-01-01

    Pilot infrastructures are becoming prominent players in the Grid environment. One of the major advantages is represented by the reduced effort required by the user communities (also known as Virtual Organizations or VOs) due to the outsourcing of the Grid interfacing services, i.e. the pilot factory, to Grid experts. One such pilot factory, based on the glideinWMS pilot infrastructure, is being operated by the Open Science Grid at University of California San Diego (UCSD). This pilot factory is serving multiple VOs from several scientific domains. Currently the three major clients are the analysis operations of the HEP experiment CMS, the community VO HCC, which serves mostly math, biology and computer science users, and the structural biology VO NEBioGrid. The UCSD glidein factory allows the served VOs to use Grid resources distributed over 150 sites in North and South America, in Europe, and in Asia. This paper presents the steps taken to create a production quality pilot factory, together with the challenges encountered along the road.

  19. Rapid biosynthesis of cadmium sulfide (CdS) nanoparticles using ...

    African Journals Online (AJOL)

    Rapid biosynthesis of cadmium sulfide (CdS) nanoparticles using culture supernatants of Escherichia coli ATCC 8739, Bacillus subtilis ATCC 6633 and Lactobacillus ... The process of extracellular and fast biosynthesis may help in the development of an easy and eco-friendly route for the synthesis of CdS nanoparticles.

  20. Rare cause of post-squalene disorder of cholesterol biosynthesis ...

    African Journals Online (AJOL)

    Errors of cholesterol biosynthesis represent a heterogeneous group of metabolic disorders. The aim of the authors of this article is to present a case of a patient with typical symptoms of a rare post-squalene disorder of cholesterol biosynthesis, its diagnostics and progress in neonatal period. The differential diagnosis of a ...

  1. Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation

    NARCIS (Netherlands)

    Houten, S. M.; Frenkel, J.; Waterham, H. R.

    2003-01-01

    Mevalonate kinase (MK) is an essential enzyme in the isoprenoid biosynthesis pathway which produces numerous biomolecules (isoprenoids) involved in a variety of cellular processes. The indispensability of MK and isoprenoid biosynthesis for human health is demonstrated by the identification of its

  2. ASME factory authorization system and the situation in Japan

    International Nuclear Information System (INIS)

    Futagawa, Kiyoshi

    1978-01-01

    Since about three or four years ago, the enterprises of machinery, iron and steel and welding materials in Japan are paying much attention to the acquisition of ASME (American Society of Mechanical Engineers) certificates or authorization to stamp the code symbols. That is, over 70 factories in Japan have undergone ASME examination, and consequently acquired the authorization or certificates. Such authorization is divided into over 20 kinds, of which about 7 are possessed by the companies in Japan. In nuclear field, the kinds of authorization are N (nuclear vessel), NPT (nuclear vessel parts), NV (nuclear vessel safety valve), and MM (material manufacturing). In non-nuclear fields, they are S (power boilers), U (pressure vessels, in Div. 1), and U2 (pressure vessels in Div. 2). The following matters are described: ASME setup, authorization procedures of ASME for factories, the kinds of authorization, factories in Japan holding the authorization or certificates, and renewal of the authorization. (Mori, K.)

  3. Synthetic yeast based cell factories for vanillin-glucoside production

    DEFF Research Database (Denmark)

    Strucko, Tomas

    and controlled expression/overexpression of genes of interest. De novo biosynthetic pathway for vanillin-β-glucoside production was employed as a model system for several case studies in this project. In order to construct yeast cell factories fulfilling current demands of industrial biotechnology, methods......The yeast Saccharomyces cerevisiae is well a characterized microorganism and widely used as eukaryotic model organism as well as a key cell factory for bioproduction of various products. The latter comprise a large variety of scientifically and industrially relevant products such as low-value bulk...... chemicals and biofuels, food additives, high-value chemicals and recombinant proteins. Despite the recent achievements in the fields of systems biology and metabolic engineering together with availability of broad genetic engineering toolbox, the full potential of S. cerevisiae as a cell factory is not yet...

  4. A factory concept for processing and manufacturing with lunar material

    Science.gov (United States)

    Driggers, G. W.

    1977-01-01

    A conceptual design for an orbital factory sized to process 1.5 million metric tons per year of raw lunar fines into 0.3 million metric tons of manufacturing materials is presented. A conservative approach involving application of present earth-based technology leads to a design devoid of new inventions. Earth based counterparts to the factory machinery were used to generate subsystem masses and lumped parameters for volume and mass estimates. The results are considered to be conservative since technologies more advanced than those assumed are presently available in many areas. Some attributes of potential space processing technologies applied to material refinement and component manufacture are discussed.

  5. Neutrino Factory and Muon Collider Collaboration R and D Program

    International Nuclear Information System (INIS)

    Zisman, M.S.

    2000-01-01

    The Neutrino Factory and Muon Collider Collaboration (MC) comprises some 140 scientists and engineers located at U.S. National Laboratories and Universities, and at a number of non-U.S. research institutions. In the past year, the MC R and D program has shifted its focus mainly toward the design issues related to the development of a Neutrino Factory based on a muon storage ring. In this paper the status of the various R and D activities is described, and future plans are outlined

  6. R and D Toward a Neutrino Factory and Muon Collider

    International Nuclear Information System (INIS)

    Zisman, Michael S.

    2011-01-01

    Significant progress has been made in recent years in R and D towards a neutrino factory and muon collider. The U.S. Muon Accelerator Program (MAP) has been formed recently to expedite the R and D efforts. This paper will review the U.S. MAP R and D programs for a neutrino factory and muon collider. Muon ionization cooling research is the key element of the program. The first muon ionization cooling demonstration experiment, MICE (Muon Ionization Cooling Experiment), is under construction now at RAL (Rutherford Appleton Laboratory) in the UK. The current status of MICE will be described.

  7. Preliminary analysis of a target factory for laser fusion

    International Nuclear Information System (INIS)

    Sherohman, J.W.; Hendricks, C.D.

    1980-01-01

    An analysis of a target factory leading to the determination of production expressions has provided for the basis of a parametric study. Parameters involving the input and output rate of a process system, processing yield factors, and multiple processing steps and production lines have been used to develop an understanding of their dependence on the rate of target injection for laser fusion. Preliminary results have indicated that a parametric study of this type will be important in the selection of processing methods to be used in the final production scheme of a target factory

  8. Jean Piaget: Images of a life and his factory.

    Science.gov (United States)

    Burman, Jeremy Trevelyan

    2012-08-01

    In this article, I use a new book about Jean Piaget to introduce a new historical method: examining "psychological factories." I also discuss some of the ways that "Great Men" are presented in the literature, as well as opportunities for new projects if one approaches the history of the discipline differently and examines the conditions that made that greatness possible. To that end, the article includes many details about Piaget that have never before been discussed in English. Attention is drawn, in particular, to Piaget's collaborators: the hundreds of workers at his factory in Geneva, many of whom were women. (PsycINFO Database Record (c) 2012 APA, all rights reserved).

  9. Profil Konsumen dan Pesaing pada “Factory Bakery”

    OpenAIRE

    Salam, Ramdhan; Rengkung, Leonardus R; Katiandagho, Theodora M; Ngangi, Charles R

    2015-01-01

    The purpose of this study was to describe the profile of competitors and consumers in the Factory Bakery. This research was conducted at the Factory Bakery is located at Pogidon Street, Tuminting, Manado. The collection of data carried out for three months, from June 2015 to Agustus 2015. The primary data in this study were taken two ways to measure the variables of consumers by asking directly to consumers for six days, whereas for measuring competitors by asking directly to the owner of th...

  10. JINR studies for a Tau-Charm Factory

    International Nuclear Information System (INIS)

    Chelkov, G.

    1994-01-01

    This paper touches on work being done a JINR relevant to a proposal for construction of a tau charm factory, and its attendant detector system. A workshop on such a device was held at JINR in 1992, and here the author touches on questions of what one wants to learn about tau particles from such a machine, the charge to the group looking at a detector design for such a facility, the general conclusions of the JINR study, and a status report of work on the JINR Tau Charm Factory project

  11. CONFOUNDING STRUCTURE OF TWO-LEVEL NONREGULAR FACTORIAL DESIGNS

    Institute of Scientific and Technical Information of China (English)

    Ren Junbai

    2012-01-01

    In design theory,the alias structure of regular fractional factorial designs is elegantly described with group theory.However,this approach cannot be applied to nonregular designs directly. For an arbitrary nonregular design,a natural question is how to describe the confounding relations between its effects,is there any inner structure similar to regular designs? The aim of this article is to answer this basic question.Using coefficients of indicator function,confounding structure of nonregular fractional factorial designs is obtained as linear constrains on the values of effects.A method to estimate the sparse significant effects in an arbitrary nonregular design is given through an example.

  12. The role of factorial cumulants in reactor neutron noise theory

    International Nuclear Information System (INIS)

    Colombino, A.; Pacilio, N.; Sena, G.

    1979-01-01

    The physical meaning and the combinatorial implications of the factorial cumulant of a state variable such as the number of neutrons or the number of neutron counts are specified. Features of the presentation are: (1) the fission process is treated in its entirety without the customary binary emission restriction, (b) the introduction of the factorial cumulants helps in reducing the complexity of the mathematical problems, (c) all the solutions can be obtained analytically. Only the ergodic hypothesis for the neutron population evolution is dealt with. (author)

  13. An asymmetric Β-factory based on PEP

    International Nuclear Information System (INIS)

    Oddone, P.

    1989-01-01

    This paper reviews the motivation for building asymmetric B-factories based on storage rings and describes the current LBL/SLAC study to develop such a factory by modifying the PEP storage ring and adding a new low energy (2.5-3 GeV) storage ring. Collisions between the beam of the modified high energy PEP ring and the low energy ring lead to a luminosity of 2 x 10 33 cm- 2 sec - 1 at E cm = Y(4s) with currents of 0.8A in each beam. Further increases in current can lead to luminosities close to 10 34 cm - 2 sec - 1

  14. PowerFactory applications for power system analysis

    CERN Document Server

    Gonzalez-Longatt, Francisco

    2014-01-01

    This book presents a comprehensive set of guidelines and applications of DIgSILENT PowerFactory, an advanced power system simulation software package, for different types of power systems studies. Written by specialists in the field, it combines expertise and years of experience in the use of DIgSILENT PowerFactory with a deep understanding of power systems analysis. These complementary approaches therefore provide a fresh perspective on how to model, simulate and analyse power systems. It presents methodological approaches for modelling of system components, including both classical and non-

  15. Cysteine Biosynthesis Controls Serratia marcescens Phospholipase Activity.

    Science.gov (United States)

    Anderson, Mark T; Mitchell, Lindsay A; Mobley, Harry L T

    2017-08-15

    Serratia marcescens causes health care-associated opportunistic infections that can be difficult to treat due to a high incidence of antibiotic resistance. One of the many secreted proteins of S. marcescens is the PhlA phospholipase enzyme. Genes involved in the production and secretion of PhlA were identified by screening a transposon insertion library for phospholipase-deficient mutants on phosphatidylcholine-containing medium. Mutations were identified in four genes ( cyaA , crp , fliJ , and fliP ) that are involved in the flagellum-dependent PhlA secretion pathway. An additional phospholipase-deficient isolate harbored a transposon insertion in the cysE gene encoding a predicted serine O -acetyltransferase required for cysteine biosynthesis. The cysE requirement for extracellular phospholipase activity was confirmed using a fluorogenic phospholipase substrate. Phospholipase activity was restored to the cysE mutant by the addition of exogenous l-cysteine or O -acetylserine to the culture medium and by genetic complementation. Additionally, phlA transcript levels were decreased 6-fold in bacteria lacking cysE and were restored with added cysteine, indicating a role for cysteine-dependent transcriptional regulation of S. marcescens phospholipase activity. S. marcescens cysE mutants also exhibited a defect in swarming motility that was correlated with reduced levels of flhD and fliA flagellar regulator gene transcription. Together, these findings suggest a model in which cysteine is required for the regulation of both extracellular phospholipase activity and surface motility in S. marcescens IMPORTANCE Serratia marcescens is known to secrete multiple extracellular enzymes, but PhlA is unusual in that this protein is thought to be exported by the flagellar transport apparatus. In this study, we demonstrate that both extracellular phospholipase activity and flagellar function are dependent on the cysteine biosynthesis pathway. Furthermore, a disruption of cysteine

  16. Biosynthesis of dipicolinic acid in Clostridium roseum

    Energy Technology Data Exchange (ETDEWEB)

    Prakasan, K. (Paraiba Univ., Joao Pessoa (Brazil)); Sharma, D. (Gobind Ballabh Pant Univ. of Agriculture and Technology, Nainital (India))

    1981-02-01

    Dipicolinic acid (DPA) synthesis was studied in Clostridium roseum by permitting the organism to complete vegetative growth in trypticase medium and trasfering the cells to a non-growth-promoting-medium, supplemented with the appropriate /sup 14/C-labelled precursors to complete sporulation and assaying the incorporation of label into DPA. Glu, asp, ala, ser and acetate were found to be efficient precursors of DPA and each one influenced the incorporation of other into DPA. The data suggest that a C/sub 5/ precursor is being trasformed into a C/sub 4/ intermediate, and a C/sub 2/ precursor into a C/sub 4/ intermediate, before their entry into DPA carbon structure. A C/sub 4/ plus C/sub 3/ condensation is favoured over C/sub 5/ plus C/sub 2/ or other condensation in the DPA biosynthesis.

  17. Polyamine biosynthesis during germination of yeast ascospores.

    Science.gov (United States)

    Brawley, J V; Ferro, A J

    1979-01-01

    The role of the diamine putrescine during germination and outgrowth of ascospores of Saccharomyces cerevisiae was examined. Ornithine decarboxylase activity increased and declined rapidly during germination and outgrowth; peak activity was attained after the cells had proceeded through the G1 interval of the cell cycle, whereas minimal activity was present at the completion of the first cell division. alpha-Methylornithine inhibited both ornithine decarboxylase activity and the in vivo accumulation of putrescine. In the presence of alpha-methylornithireak dormancy and proceed through one cell division. Subsequent cellular growth, however, was retarded but not completely inhibited. The supplementation of Methylglyoxal bis(guanylhydrazone) to sporulation medium greatly inhibited this sexual process. These data suggest that the synthesis of putrescine is not required for the breaking of spore dormancy, but that polyamine biosynthesis may be essential for meiosis and sporulation. PMID:387744

  18. Biosurfactant Mediated Biosynthesis of Selected Metallic Nanoparticles

    Science.gov (United States)

    Płaza, Grażyna A.; Chojniak, Joanna; Banat, Ibrahim M.

    2014-01-01

    Developing a reliable experimental protocol for the synthesis of nanomaterials is one of the challenging topics in current nanotechnology particularly in the context of the recent drive to promote green technologies in their synthesis. The increasing need to develop clean, nontoxic and environmentally safe production processes for nanoparticles to reduce environmental impact, minimize waste and increase energy efficiency has become essential in this field. Consequently, recent studies on the use of microorganisms in the synthesis of selected nanoparticles are gaining increased interest as they represent an exciting area of research with considerable development potential. Microorganisms are known to be capable of synthesizing inorganic molecules that are deposited either intra- or extracellularly. This review presents a brief overview of current research on the use of biosurfactants in the biosynthesis of selected metallic nanoparticles and their potential importance. PMID:25110864

  19. Terpenoids and Their Biosynthesis in Cyanobacteria

    Directory of Open Access Journals (Sweden)

    Bagmi Pattanaik

    2015-01-01

    Full Text Available Terpenoids, or isoprenoids, are a family of compounds with great structural diversity which are essential for all living organisms. In cyanobacteria, they are synthesized from the methylerythritol-phosphate (MEP pathway, using glyceraldehyde 3-phosphate and pyruvate produced by photosynthesis as substrates. The products of the MEP pathway are the isomeric five-carbon compounds isopentenyl diphosphate and dimethylallyl diphosphate, which in turn form the basic building blocks for formation of all terpenoids. Many terpenoid compounds have useful properties and are of interest in the fields of pharmaceuticals and nutrition, and even potentially as future biofuels. The MEP pathway, its function and regulation, and the subsequent formation of terpenoids have not been fully elucidated in cyanobacteria, despite its relevance for biotechnological applications. In this review, we summarize the present knowledge about cyanobacterial terpenoid biosynthesis, both regarding the native metabolism and regarding metabolic engineering of cyanobacteria for heterologous production of non-native terpenoids.

  20. Terpenoids and Their Biosynthesis in Cyanobacteria

    Science.gov (United States)

    Pattanaik, Bagmi; Lindberg, Pia

    2015-01-01

    Terpenoids, or isoprenoids, are a family of compounds with great structural diversity which are essential for all living organisms. In cyanobacteria, they are synthesized from the methylerythritol-phosphate (MEP) pathway, using glyceraldehyde 3-phosphate and pyruvate produced by photosynthesis as substrates. The products of the MEP pathway are the isomeric five-carbon compounds isopentenyl diphosphate and dimethylallyl diphosphate, which in turn form the basic building blocks for formation of all terpenoids. Many terpenoid compounds have useful properties and are of interest in the fields of pharmaceuticals and nutrition, and even potentially as future biofuels. The MEP pathway, its function and regulation, and the subsequent formation of terpenoids have not been fully elucidated in cyanobacteria, despite its relevance for biotechnological applications. In this review, we summarize the present knowledge about cyanobacterial terpenoid biosynthesis, both regarding the native metabolism and regarding metabolic engineering of cyanobacteria for heterologous production of non-native terpenoids. PMID:25615610

  1. Biosurfactant Mediated Biosynthesis of Selected Metallic Nanoparticles

    Directory of Open Access Journals (Sweden)

    Grażyna A. Płaza

    2014-08-01

    Full Text Available Developing a reliable experimental protocol for the synthesis of nanomaterials is one of the challenging topics in current nanotechnology particularly in the context of the recent drive to promote green technologies in their synthesis. The increasing need to develop clean, nontoxic and environmentally safe production processes for nanoparticles to reduce environmental impact, minimize waste and increase energy efficiency has become essential in this field. Consequently, recent studies on the use of microorganisms in the synthesis of selected nanoparticles are gaining increased interest as they represent an exciting area of research with considerable development potential. Microorganisms are known to be capable of synthesizing inorganic molecules that are deposited either intra- or extracellularly. This review presents a brief overview of current research on the use of biosurfactants in the biosynthesis of selected metallic nanoparticles and their potential importance.

  2. Biosynthesis of dipicolinic acid in Clostridium roseum

    International Nuclear Information System (INIS)

    Prakasan, K.; Sharma, D.

    1981-01-01

    Dipicolinic acid (DPA) synthesis was studied in Clostridium roseum by permitting the organism to complete vegetative growth in trypticase medium and trasfering the cells to a non-growth-promoting-medium, supplemented with the appropriate 14 C-labelled precursors to complete sporulation and assaying the incorporation of label into DPA. Glu, asp, ala, ser and acetate were found to be efficient precursors of DPA and each one influenced the incorporation of other into DPA. The data suggest that a C 5 precursor is being trasformed into a C 4 intermediate, and a C 2 precursor into a C 4 intermediate, before their entry into DPA carbon structure. A C 4 plus C 3 condensation is favoured over C 5 plus C 2 or other condensation in the DPA biosynthesis. (Author) [pt

  3. Biosynthesis and function of plant lipids

    International Nuclear Information System (INIS)

    Thomson, W.W.; Mudd, J.B.; Gibbs, M.

    1983-01-01

    The Sixth Annual Symposium in Botany and Plant Physiology was held January 13-15, 1983, at the University of California, Riverside. This volume comprises the papers that were presented. Subjects discussed at the symposium covered a wide range in the field of plant lipids. Biosynthesis of lipids occupied an important fraction of the presentations at the symposium. Subjects included detailed studies of the enzymes of fatty acid synthesis, several discussions of the incorporation of fatty acids into glycerolipids and the further modification of the fatty acids, and the synthesis of glycerolipids and desaturation of fatty acids in both maturing oilseeds and chloroplasts. The physicochemical studies of glycerolipids and sterols in artificial membranes have led to distinct conclusions about their behaviour which must be relevant in the biological membrane. Results on the functional consequences of modifying the galactolipid composition in the chloroplast were an encouraging sign of progress in the attempts to relate membrane lipid composition to physiological function

  4. A Molecular Description of Cellulose Biosynthesis

    Science.gov (United States)

    McNamara, Joshua T.; Morgan, Jacob L.W.; Zimmer, Jochen

    2016-01-01

    Cellulose is the most abundant biopolymer on Earth, and certain organisms from bacteria to plants and animals synthesize cellulose as an extracellular polymer for various biological functions. Humans have used cellulose for millennia as a material and an energy source, and the advent of a lignocellulosic fuel industry will elevate it to the primary carbon source for the burgeoning renewable energy sector. Despite the biological and societal importance of cellulose, the molecular mechanism by which it is synthesized is now only beginning to emerge. On the basis of recent advances in structural and molecular biology on bacterial cellulose synthases, we review emerging concepts of how the enzymes polymerize glucose molecules, how the nascent polymer is transported across the plasma membrane, and how bacterial cellulose biosynthesis is regulated during biofilm formation. Additionally, we review evolutionary commonalities and differences between cellulose synthases that modulate the nature of the cellulose product formed. PMID:26034894

  5. Phenylpropenes: Occurrence, Distribution, and Biosynthesis in Fruit.

    Science.gov (United States)

    Atkinson, Ross G

    2018-03-14

    Phenylpropenes such as eugenol, chavicol, estragole, and anethole contribute to the flavor and aroma of a number of important herbs and spices. They have been shown to function as floral attractants for pollinators and to have antifungal and antimicrobial activities. Phenylpropenes are also detected as free volatiles and sequestered glycosides in a range of economically important fresh fruit species including apple, strawberry, tomato, and grape. Although they contribute a relatively small percentage of total volatiles compared with esters, aldehydes, and alcohols, phenylpropenes have been shown to contribute spicy anise- and clove-like notes to fruit. Phenylpropenes are typically found in fruit throughout development and to reach maximum concentrations in ripe fruit. Genes involved in the biosynthesis of phenylpropenes have been characterized and manipulated in strawberry and apple, which has validated the importance of these compounds to fruit aroma and may help elucidate other functions for phenylpropenes in fruit.

  6. Collagens--structure, function, and biosynthesis.

    Science.gov (United States)

    Gelse, K; Pöschl, E; Aigner, T

    2003-11-28

    The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified so far. Collagens are centrally involved in the formation of fibrillar and microfibrillar networks of the extracellular matrix, basement membranes as well as other structures of the extracellular matrix. This review focuses on the distribution and function of various collagen types in different tissues. It introduces their basic structural subunits and points out major steps in the biosynthesis and supramolecular processing of fibrillar collagens as prototypical members of this protein family. A final outlook indicates the importance of different collagen types not only for the understanding of collagen-related diseases, but also as a basis for the therapeutical use of members of this protein family discussed in other chapters of this issue.

  7. Biosynthesis of archaeal membrane ether lipids

    Directory of Open Access Journals (Sweden)

    Samta eJain

    2014-11-01

    Full Text Available A vital function of the cell membrane in all living organism is to maintain the membrane permeability barrier and fluidity. The composition of the phospholipid bilayer is distinct in archaea when compared to bacteria and eukarya. In archaea, isoprenoid hydrocarbon side chains are linked via an ether bond to the sn-glycerol-1-phosphate backbone. In bacteria and eukarya on the other hand, fatty acid side chains are linked via an ester bond to the sn-glycerol-3-phosphate backbone. The polar head groups are globally shared in the three domains of life. The unique membrane lipids of archaea have been implicated not only in the survival and adaptation of the organisms to extreme environments but also to form the basis of the membrane composition of the last universal common ancestor (LUCA. In nature, a diverse range of archaeal lipids is found, the most common are the diether (or archaeol and the tetraether (or caldarchaeol lipids that form a monolayer. Variations in chain length, cyclization and other modifications lead to diversification of these lipids. The biosynthesis of these lipids is not yet well understood however progress in the last decade has led to a comprehensive understanding of the biosynthesis of archaeol. This review describes the current knowledge of the biosynthetic pathway of archaeal ether lipids; insights on the stability and robustness of archaeal lipid membranes; and evolutionary aspects of the lipid divide and the last universal common ancestor LUCA. It examines recent advances made in the field of pathway reconstruction in bacteria.

  8. In vitro biosynthesis of complement protein D

    International Nuclear Information System (INIS)

    Barnum, S.R.

    1985-01-01

    The aim of this study was twofold: to determine site(s) of complement protein D biosynthesis and to examine D biosynthesis with respect to the kinetics of D secretion, the post-translational modification of D and the tissue-specific differences in D secretion and processing. Antigenic D was detected in the culture supernatants of two cell lines, U937 and HepG2, and adherent blood monocytes by a solid-phase radioimmunoassay. D secreted by U937 cells was hemolytically active with a specific activity comparable to D in serum. De novo synthesis of D by U937 cells was demonstrated with the use of cycloheximide. Biosynthetic labeling using 35 S labeled methionine or cysteine, followed by immunoprecipitation demonstrated a single d band intra- and extra-cellularly in all three cell types as analyzed by SDS-PAGE and auto-radiography. Elevated serum D levels in individuals with IgA nephropathy led to studies on the D levels in serum and urine of individuals with chronic renal failure and an individual with Fanconi's syndrome. The former group had elevated serum D levels, compared to normals, and insignificant levels of D in their urine while the patient with Fanconi's syndrome had normal serum D levels but markedly elevated urinary D levels. These studies demonstrate that the monocyte and hepatocyte are both sites of D synthesis and that there are no apparent differences in the secretion rates and processing of D produced by these cell types. The results also suggest that D is not synthesized or secreted as a precursor molecule. Additionally, these studies suggest that the kidney is a major site of D catabolism

  9. Review of North American Neutrino Factory R and D

    International Nuclear Information System (INIS)

    Zisman, Michael S.; Neutrino Factory and Muon Collider Collaboration

    2002-01-01

    We report here on the R and D program of the U.S. Neutrino Factory and Muon Collider Collaboration. Our effort includes work on targetry, muon ionization cooling, simulation work, and development of superconducting RF cavities. In addition, we are involved in the international effort toward a Muon Ionization Cooling Experiment (MICE). Recent activities in all these areas will be described

  10. Development in the Learning Factory: Training Human Capital.

    Science.gov (United States)

    Barton, Harry; Delbridge, Rick

    2001-01-01

    A study of human resource practices in 18 automobile factories in the United States and Britain showed that manufacturing innovations are placing greater demands on line managers and workers. Training is being refocused to develop their interpersonal, team, and leadership skills. However, lack of time and suitable training facilities are barriers.…

  11. Manufacturing data analytics using a virtual factory representation.

    Science.gov (United States)

    Jain, Sanjay; Shao, Guodong; Shin, Seung-Jun

    2017-01-01

    Large manufacturers have been using simulation to support decision-making for design and production. However, with the advancement of technologies and the emergence of big data, simulation can be utilised to perform and support data analytics for associated performance gains. This requires not only significant model development expertise, but also huge data collection and analysis efforts. This paper presents an approach within the frameworks of Design Science Research Methodology and prototyping to address the challenge of increasing the use of modelling, simulation and data analytics in manufacturing via reduction of the development effort. The use of manufacturing simulation models is presented as data analytics applications themselves and for supporting other data analytics applications by serving as data generators and as a tool for validation. The virtual factory concept is presented as the vehicle for manufacturing modelling and simulation. Virtual factory goes beyond traditional simulation models of factories to include multi-resolution modelling capabilities and thus allowing analysis at varying levels of detail. A path is proposed for implementation of the virtual factory concept that builds on developments in technologies and standards. A virtual machine prototype is provided as a demonstration of the use of a virtual representation for manufacturing data analytics.

  12. Physics of a high-luminosity Tau-Charm Factory

    International Nuclear Information System (INIS)

    King, M.E.

    1992-10-01

    This paper highlights the physics capabilities of a Tau-Charm Factory; i.e., high luminosity (∼10 33 cm -2 s -1 ) e + e - collider operating in the center-of-mass energy range of 3-5 GeV, with a high-precision, general-purpose detector. Recent developments in τ and charm physics are emphasized

  13. Lettuce growth and quality optimization in a plant factory

    NARCIS (Netherlands)

    Nicole, C.C.S.; Charalambous, F.; Martinakos, S.; De Voort, Van S.; Li, Z.; Verhoog, M.; Krijn, M.

    2016-01-01

    Since the early 2000s, plant factory (or vertical farm) technology has been introduced for growing vegetables and soft fruits. With a well-controlled environment, new health benefits, food safety, optimized nutrients and increased shelf-life can be offered to consumers. With the progress of light

  14. Introduction to radiation backgrounds in a B factory

    International Nuclear Information System (INIS)

    Khan, S.

    1992-08-01

    Detector backgrounds in a B factory due to synchrotron radiation and beam-gas interactions are discussed and the computational tools to simulate these processes are outlined. As an example of their application, simulations and beam tests that preceded the installation of the ARGUS silicon vertex detector are described. (orig.)

  15. Factorial study of rain garden design for nitrogen removal

    Science.gov (United States)

    Abstract Nitrate (〖NO〗_3^--N ) removal studies in bioretention systems showed great variability in removal rates and in some cases 〖NO〗_3^--N was exported. A 3-way factorial design (2 x 2 x 4) was devised for eight outdoor un-vegetated rain gardens to evaluate the effects of ...

  16. Mobile monitoring and embedded control system for factory environment.

    Science.gov (United States)

    Lian, Kuang-Yow; Hsiao, Sung-Jung; Sung, Wen-Tsai

    2013-12-17

    This paper proposes a real-time method to carry out the monitoring of factory zone temperatures, humidity and air quality using smart phones. At the same time, the system detects possible flames, and analyzes and monitors electrical load. The monitoring also includes detecting the vibrations of operating machinery in the factory area. The research proposes using ZigBee and Wi-Fi protocol intelligent monitoring system integration within the entire plant framework. The sensors on the factory site deliver messages and real-time sensing data to an integrated embedded systems via the ZigBee protocol. The integrated embedded system is built by the open-source 32-bit ARM (Advanced RISC Machine) core Arduino Due module, where the network control codes are built in for the ARM chipset integrated controller. The intelligent integrated controller is able to instantly provide numerical analysis results according to the received data from the ZigBee sensors. The Android APP and web-based platform are used to show measurement results. The built-up system will transfer these results to a specified cloud device using the TCP/IP protocol. Finally, the Fast Fourier Transform (FFT) approach is used to analyze the power loads in the factory zones. Moreover, Near Field Communication (NFC) technology is used to carry out the actual electricity load experiments using smart phones.

  17. A factorial experiment on image quality and radiation dose

    International Nuclear Information System (INIS)

    Norrman, E.; Persliden, J.

    2005-01-01

    To find if factorial experiments can be used in the optimisation of diagnostic imaging, a factorial experiment was performed to investigate some of the factors that influence image quality, kerma area product (KAP) and effective dose (E). In a factorial experiment the factors are varied together instead of one at a time, making it possible to discover interactions between the factors as well as major effects. The factors studied were tube potential, tube loading, focus size and filtration. Each factor was set to two levels (low and high). The influence of the factors on the response variables (image quality, KAP and E) was studied using a direct digital detector. The major effects of each factor on the response variables were estimated as well as the interaction effects between factors. The image quality, KAP and E were mainly influenced by tube loading, tube potential and filtration. There were some active interactions, for example, between tube potential and filtration and between tube loading and filtration. The study shows that factorial experiments can be used to predict the influence of various parameters on image quality and radiation dose. (authors)

  18. Pioneering role of the KEKB B-factory

    International Nuclear Information System (INIS)

    Oide, Katsunobu

    2009-01-01

    The KEKB B-factory experimentally verified the Kobayashi-Masukawa theory, and contributed to their 2008 Nobel Prize in Physics. KEKB has realized various innovative technologies to achieve the highest luminosity in the world. KEKB has opened up a new frontier of high-luminosity colliders. (author)

  19. Factory Acceptance Test Procedure Westinghouse 100 ton Hydraulic Trailer

    International Nuclear Information System (INIS)

    Aftanas, B.L.

    1994-01-01

    This Factory Acceptance Test Procedure (FAT) is for the Westinghouse 100 Ton Hydraulic Trailer. The trailer will be used for the removal of the 101-SY pump. This procedure includes: safety check and safety procedures; pre-operation check out; startup; leveling trailer; functional/proofload test; proofload testing; and rolling load test

  20. RIKEN radioactive isotope beam factory project – Present status and ...

    Indian Academy of Sciences (India)

    Programs for studying nuclear reactions and structure of exotic nuclei available at the RIKEN radioactive isotope beam factory project are introduced and discussed by demonstrating recent highlights. Special emphasis ... RIKEN Nishina Center for Accelerator-Based Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan ...

  1. 3D thermal climate monitoring in factory buildings

    NARCIS (Netherlands)

    Posselt, G.; Booij, P.S.; Thiede, S.; Fransman, J.E.; Driessen, B.J.F.; Herrmann, C.

    2015-01-01

    Guaranteeing defined conditions, such as the temperature levels inside the factory's building shell, is often important to produce high-quality products. Heating, ventilation and air conditioning (HVAC) equipment, as part of the technical building services, is energy intensive and accounts for a

  2. Proceedings of the tau-charm factory workshop

    International Nuclear Information System (INIS)

    Beers, L.V.

    1989-06-01

    This report contains papers on the following main topics: machine physics; tau physics; D and D s physics; J/Ψ and charmonium physics; tau charm factories; workshop summary; accelerator physics; tau physics; charmed meson physics; J/Ψ and charmonium physics; and detector

  3. Child Protection Decision Making: A Factorial Analysis Using Case Vignettes

    Science.gov (United States)

    Stokes, Jacqueline; Schmidt, Glen

    2012-01-01

    This study explored decision making by child protection social workers in the province of British Columbia, Canada. A factorial survey method was used in which case vignettes were constructed by randomly assigning a number of key characteristics associated with decision making in child protection. Child protection social workers (n = 118) assessed…

  4. Reward-allocation judgments in Romania : A factorial survey approach

    NARCIS (Netherlands)

    Buzea, C.; Meseşan-Schmitz, L.; van de Vijver, F.J.R.

    2013-01-01

    We investigated reward-allocation judgments when positive outcomes (monetary rewards) were distributed and the allocator was not a co-recipient, in a sample of 200 Romanian students. Within a full factorial survey design, seven factors, selected to affect the allocation decision, were orthogonally

  5. Two ways factorial design for round robin test of anemometers

    International Nuclear Information System (INIS)

    Cuerva, A.

    1998-01-01

    This work presents a way to carry out an inter-comparison between different cup anemometers that are tested in different wind tunnels. The method applied is known as Factorial design and allows determining the influence in the test of different factors in this case the anemometer itself and the wind tunnel where it is tested. (Author) 4 refs

  6. Designing fractional factorial split-plot experiments using integer programming

    DEFF Research Database (Denmark)

    Capehart, Shay R.; Keha, Ahmet; Kulahci, Murat

    2011-01-01

    factorial (FF) design, with the restricted randomisation structure to account for the whole plots and subplots. We discuss the formulation of FFSP designs using integer programming (IP) to achieve various design criteria. We specifically look at the maximum number of clear two-factor interactions...

  7. Constructing General Orthogonal Fractional Factorial Split-Plot Designs

    NARCIS (Netherlands)

    Sartono, B.; Goos, P.; Schoen, E.

    2015-01-01

    While the orthogonal design of split-plot fractional factorial experiments has received much attention already, there are still major voids in the literature. First, designs with one or more factors acting at more than two levels have not yet been considered. Second, published work on nonregular

  8. Neutrino Factory R and D in the U.S

    International Nuclear Information System (INIS)

    Zisman, Michael S.

    2003-01-01

    We report here on the technical progress and R andD plans of the U.S. Neutrino Factory and Muon Collider Collaboration. Programs in targetry, cooling, acceleration, and simulations are covered. U.S. activities in support of the international Muon Ionization Cooling Experiment (MICE) are also described

  9. Muon physics possibilities at a muon-neutrino factory

    NARCIS (Netherlands)

    Jungmann, KP

    2001-01-01

    New intense proton accelerators with above GeV energies and MW beam power, such as they are discussed in connection with neutrino factories, appear to be excellently suited for feeding bright muon sources for low-energy muon science. Muon rates with several orders of magnitude increased flux

  10. Limit values in special agreements between factories and sewage works

    International Nuclear Information System (INIS)

    Lundstroem, Yrjoe

    1987-01-01

    The operation of sewage works is controlled in Finland by the water and health authorities. These authorities set special quality demands for the effluent from sewage treatment plants into the recipient. Also other wastes from treatment plants, mainly sludges, have special regulations and operational target values. Sewage works have to achieve the aim goals and limit values set. In order to fulfill the regulations, sewage works impose such limit values on factory wastewaters that there will be no problems at the treatment plants. Sewage works can act in two ways: - require the factory to operate in such a way that the limit values are not exceeded, - the factory pays a certain sum of money to the sewage works, which takes care of the whole problem. It can be said in general, that it is not possible to get rid of harmful substances by payment to the sewage works if the substances cause treatment problems or problems in sludge disposal. If the factory produces wastewater that contains a higher organic load, more suspended solids or a higher nutrient load than normal sanitary wastewater, the problem is most often solved by paying an extra fee to the sewage works

  11. 29 BABY DUMPING AND EVOLVING BABY FACTORIES IN NIGERIA

    African Journals Online (AJOL)

    room for a conducive environment for child rights and social protection. ... new dimensions to include the worst of all forms of human trafficking issues ... of strict penalties for offenders in the bid to give every child born the benefit of ..... vein, the study conducted by Onuoha (2014) listed the causes of baby factory incidences to.

  12. Feasibility study for an asymmetric B-factory at KEK

    International Nuclear Information System (INIS)

    Ozaki, Hitoshi; Yoshimura, Yoshio

    1990-06-01

    In June, 1989, the study group for exploring the feasibility of B meson physics using an asymmetric energy accelerator was organized. This report is the summary of the results of the works that this study group carried out in nine months, and is the Japanese edition of the report of English edition 'Task Force Report on Asymmetric B-factory at KEK'. The activity plan of the study group was to make up the plan exceeding the preceding CLEO-2 experiment by utilizing the features of an asymmetric B-factory. Under this plan, the activities have been carried out by the study meetings twice every week on the physics side and once every two weeks on the accelerator side. Besides, in two study meetings held in October and December, 1989, several persons who have engaged in the research on B meson physics actually in foreign countries were invited, and the discussion was carried out. At present toward the materialization of the plan, the concrete investigation of accelerators and measuring instruments was begun. The significance of a B-factory and the construction project, the physics of a B-factory, the experimental method and the plan for an accelerator are reported. (K.I.)

  13. Two Ways Factorial Design for round robin test of anemometers

    Energy Technology Data Exchange (ETDEWEB)

    Cuerva, A.

    1998-07-01

    This work presents a way to carry out an inter-comparison between different cup anemometers that are tested in different wind tunnels. The method applied is known as Factorial design and allows determining the influence in the test of different factors in this case the anemometer itself and the wind tunnel where it is tested. (Author) 4 refs.

  14. Reallocating resources to focused factories: a case study in chemotherapy

    NARCIS (Netherlands)

    Vanberkel, P.T.; Boucherie, Richardus J.; Hans, Elias W.; Hurink, Johann L.; Litvak, Nelli; van Lent, W.A.M.; van Harten, Willem H.; van Harten, Wim H.; Blake, J.; Carter, M.

    2010-01-01

    This study investigates the expected service performance associated with a proposal to reallocate resources from a centralized chemotherapy department to a breast cancer focused factory. Using a slotted queueing model we show that a decrease in performance is expected and calculate the amount of

  15. Mobile Monitoring and Embedded Control System for Factory Environment

    Science.gov (United States)

    Lian, Kuang-Yow; Hsiao, Sung-Jung; Sung, Wen-Tsai

    2013-01-01

    This paper proposes a real-time method to carry out the monitoring of factory zone temperatures, humidity and air quality using smart phones. At the same time, the system detects possible flames, and analyzes and monitors electrical load. The monitoring also includes detecting the vibrations of operating machinery in the factory area. The research proposes using ZigBee and Wi-Fi protocol intelligent monitoring system integration within the entire plant framework. The sensors on the factory site deliver messages and real-time sensing data to an integrated embedded systems via the ZigBee protocol. The integrated embedded system is built by the open-source 32-bit ARM (Advanced RISC Machine) core Arduino Due module, where the network control codes are built in for the ARM chipset integrated controller. The intelligent integrated controller is able to instantly provide numerical analysis results according to the received data from the ZigBee sensors. The Android APP and web-based platform are used to show measurement results. The built-up system will transfer these results to a specified cloud device using the TCP/IP protocol. Finally, the Fast Fourier Transform (FFT) approach is used to analyze the power loads in the factory zones. Moreover, Near Field Communication (NFC) technology is used to carry out the actual electricity load experiments using smart phones. PMID:24351642

  16. Mobile Monitoring and Embedded Control System for Factory Environment

    Directory of Open Access Journals (Sweden)

    Kuang-Yow Lian

    2013-12-01

    Full Text Available This paper proposes a real-time method to carry out the monitoring of factory zone temperatures, humidity and air quality using smart phones. At the same time, the system detects possible flames, and analyzes and monitors electrical load. The monitoring also includes detecting the vibrations of operating machinery in the factory area. The research proposes using ZigBee and Wi-Fi protocol intelligent monitoring system integration within the entire plant framework. The sensors on the factory site deliver messages and real-time sensing data to an integrated embedded systems via the ZigBee protocol. The integrated embedded system is built by the open-source 32-bit ARM (Advanced RISC Machine core Arduino Due module, where the network control codes are built in for the ARM chipset integrated controller. The intelligent integrated controller is able to instantly provide numerical analysis results according to the received data from the ZigBee sensors. The Android APP and web-based platform are used to show measurement results. The built-up system will transfer these results to a specified cloud device using the TCP/IP protocol. Finally, the Fast Fourier Transform (FFT approach is used to analyze the power loads in the factory zones. Moreover, Near Field Communication (NFC technology is used to carry out the actual electricity load experiments using smart phones.

  17. A Neutrosophic Binomial Factorial Theorem with their Refrains

    Directory of Open Access Journals (Sweden)

    Huda E. Khalid

    2016-12-01

    Full Text Available The Neutrosophic Precalculus and the Neutrosophic Calculus can be developed in many ways, depending on the types of indeterminacy one has and on the method used to deal with such indeterminacy. This article is innovative since the form of neutrosophic binomial factorial theorem was constructed in addition to its refrains.

  18. Holland Code, Job Satisfaction and Productivity in Clothing Factory Workers.

    Science.gov (United States)

    Heesacker, Martin; And Others

    Published research on vocational interests and personality has not often assessed the characteristics of workers and the work environment in blue-collar, women-dominated industries. This study administered the Self-Directed Search (Form E) to 318 sewing machine operators in three clothing factories. Holland codes, productivity, job satisfaction,…

  19. Monitoring public health following a major firework factory explosion.

    NARCIS (Netherlands)

    Dirkzwager, A.J.E.; IJzermans, C.J.; Kerssens, J.J.

    2003-01-01

    Background: In May 2000, a firework factory exploded in a residential area in the Netherlands, resulting in 22 deaths, 947 wounded people, and about 2.000 severely damaged houses. Following the explosion, a largescale monitoring study was implemented to examine disaster-related health consequences

  20. Monitoring health status following a major firework factory explosion.

    NARCIS (Netherlands)

    Dirkzwager, A.; IJzermans, J.

    2003-01-01

    In May 2000, a firework factory exploded in a residential area in the Netherlands, resulting in 22 death, 947 wounded people, 500 destroyed houses, and 1.500 severely damaged houses. Following the explosion, a large-scale monitoring study was implemented to investigate disaster-related health

  1. The Layout of Power and Space in Jingdezhen Imperial Factory

    Directory of Open Access Journals (Sweden)

    Zhan Jia

    2014-12-01

    Full Text Available This paper, by referring to the archaeological reports and local gazetteers and comparing images of porcelain wares, makes a comprehensive and in-depth analysis of the layout of power and space in Jingdezhen Imperial Factory according to its geography, geomancy, security management, space regulation, architectural features, production characteristics and production layout. It contends that the Imperial Factory which integrates porcelain making factory with local government is the embodiment of absolute monarchy in ceramic culture. The factory is located on Zhushan mountain, the center of Jingdezhen’s industry, business and transportation. Being at the center, it gives off an air of prestige and majesty, overlooking dominantly the surrounding private kilns. It has also turned the political system into power operation, setting up not only workshops but also administrative offices. By taking advantage of the best resources, it has produced porcelain for imperial family and court. Its specialized production has solved the contradiction between complicated technology and numerous procedures of production. The shape, color and pattern of the porcelain wares are strictly stipulated and the best of the best wares are demanded. Hence the porcelain production is featured with longest firing, largest scale, superb craftsmanship, and best kinds of wares. All of these reveal the process and rule power and space are intersected and different cultures overlapped.

  2. Improving the Welfare of Women Factory Workers: Lessons from Indonesia.

    Science.gov (United States)

    White, Mary C.

    1990-01-01

    Attention to the quality of the working environment for women factory workers can make a real contribution to productivity. The example of an Indonesian project that introduced low-cost workplace improvements and provided health instruction shows the feasibility and effectiveness of such efforts, provided there is a clear commitment from…

  3. Beam finding algorithms at the interaction point of B factories

    International Nuclear Information System (INIS)

    Kozanecki, W.

    1992-10-01

    We review existing methods to bring beams in collision in circular machines, and examine collision alignment strategies proposed for e + e - B-factories. The two-ring feature of such machines, while imposing more stringent demands on beam control, also opens up new diagnostic possibilities

  4. Bioretention Systems: Partial Factorial Designs for Nitrate Removal

    Science.gov (United States)

    Changes in nutrient loadings are monitored by introducing captured stormwater runoff into eight outdoor rain gardens at EPA’s Urban Water Research Facility in Edison, New Jersey scaled for residential and urban landscapes. The partial factorial design includes non-vegetated meso...

  5. Search for new physics at a super-B factory

    Indian Academy of Sciences (India)

    The importance of a super- factory in the search for new physics, in particular, due to CP-odd phase(s) from physics beyond the standard model is surveyed. The first point to emphasize is that we now know how to directly measure all three angles of the unitarity triangle very cleanly, i.e. without theoretical assumptions with ...

  6. Phenomenology of neutrino oscillations at the neutrino factory

    International Nuclear Information System (INIS)

    Tang, Jian

    2011-01-01

    We consider the prospects for a neutrino factory measuring mixing angles, the CP violating phase and mass-squared differences by detecting wrong-charge muons arising from the chain μ + → ν e → ν μ → μ - and the right-charge muons coming from the chain μ + → anti ν μ → anti ν μ → μ - (similar to μ - chains), where ν e → ν μ and anti ν μ → anti ν μ are neutrino oscillation channels through a long baseline. First, we study physics with near detectors and consider the treatment of systematic errors including cross section errors, flux errors, and background uncertainties. We illustrate for which measurements near detectors are required, discuss how many are needed, and what the role of the flux monitoring is. We demonstrate that near detectors are mandatory for the leading atmospheric parameter measurements if the neutrino factory has only one baseline, whereas systematic errors partially cancel if the neutrino factory complex includes the magic baseline. Second, we perform the baseline and energy optimization of the neutrino factory including the latest simulation results from the magnetized iron neutrino detector (MIND). We also consider the impact of τ decays, generated by appearance channels ν μ → ν τ and ν e → ν τ , on the discovery reaches of the mass orderings, the leptonic CP violation, and the non-zero θ 13 , which we find to be negligible for the considered detector. Third, we make a comparison of a high energy neutrino factory to a low energy neutrino factory and find that they are just two versions of the same experiment optimized for different regions of the parameter space. In addition, we briefly comment on whether it is useful to build the bi-magic baseline at the low energy neutrino factory. Finally, the effects of one additional massive sterile neutrino are discussed in the context of a combined short and long baseline setup. It is found that near detectors can provide the required sensitivity at the

  7. Phenomenology of neutrino oscillations at the neutrino factory

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Jian

    2011-12-19

    We consider the prospects for a neutrino factory measuring mixing angles, the CP violating phase and mass-squared differences by detecting wrong-charge muons arising from the chain {mu}{sup +} {yields} {nu}{sub e} {yields} {nu}{sub {mu}} {yields} {mu}{sup -} and the right-charge muons coming from the chain {mu}{sup +} {yields} anti {nu}{sub {mu}} {yields} anti {nu}{sub {mu}} {yields} {mu}{sup -} (similar to {mu}{sup -} chains), where {nu}{sub e} {yields} {nu}{sub {mu}} and anti {nu}{sub {mu}} {yields} anti {nu}{sub {mu}} are neutrino oscillation channels through a long baseline. First, we study physics with near detectors and consider the treatment of systematic errors including cross section errors, flux errors, and background uncertainties. We illustrate for which measurements near detectors are required, discuss how many are needed, and what the role of the flux monitoring is. We demonstrate that near detectors are mandatory for the leading atmospheric parameter measurements if the neutrino factory has only one baseline, whereas systematic errors partially cancel if the neutrino factory complex includes the magic baseline. Second, we perform the baseline and energy optimization of the neutrino factory including the latest simulation results from the magnetized iron neutrino detector (MIND). We also consider the impact of {tau} decays, generated by appearance channels {nu}{sub {mu}} {yields} {nu}{sub {tau}} and {nu}{sub e} {yields} {nu}{sub {tau}}, on the discovery reaches of the mass orderings, the leptonic CP violation, and the non-zero {theta}{sub 13}, which we find to be negligible for the considered detector. Third, we make a comparison of a high energy neutrino factory to a low energy neutrino factory and find that they are just two versions of the same experiment optimized for different regions of the parameter space. In addition, we briefly comment on whether it is useful to build the bi-magic baseline at the low energy neutrino factory. Finally, the

  8. PLANT VOLATILES. Biosynthesis of monoterpene scent compounds in roses.

    Science.gov (United States)

    Magnard, Jean-Louis; Roccia, Aymeric; Caissard, Jean-Claude; Vergne, Philippe; Sun, Pulu; Hecquet, Romain; Dubois, Annick; Hibrand-Saint Oyant, Laurence; Jullien, Frédéric; Nicolè, Florence; Raymond, Olivier; Huguet, Stéphanie; Baltenweck, Raymonde; Meyer, Sophie; Claudel, Patricia; Jeauffre, Julien; Rohmer, Michel; Foucher, Fabrice; Hugueney, Philippe; Bendahmane, Mohammed; Baudino, Sylvie

    2015-07-03

    The scent of roses (Rosa x hybrida) is composed of hundreds of volatile molecules. Monoterpenes represent up to 70% percent of the scent content in some cultivars, such as the Papa Meilland rose. Monoterpene biosynthesis in plants relies on plastid-localized terpene synthases. Combining transcriptomic and genetic approaches, we show that the Nudix hydrolase RhNUDX1, localized in the cytoplasm, is part of a pathway for the biosynthesis of free monoterpene alcohols that contribute to fragrance in roses. The RhNUDX1 protein shows geranyl diphosphate diphosphohydrolase activity in vitro and supports geraniol biosynthesis in planta. Copyright © 2015, American Association for the Advancement of Science.

  9. Energy usage in Beet Suger Factories. Sockerfabrikens energianvaendning; En systemstudie

    Energy Technology Data Exchange (ETDEWEB)

    Feltborg, G

    1990-02-01

    A computer program has been developed in order to simulate the energy consumption of beet sugar factories, for various plant configurations. The program is divided into five block units: Extraction and Juice purification, Juice concentration, Crystallization, Drying and finally the Power House. Each block consists of different modules, for example, a heat exchanger, an evaporator, a turbine and a dryer. The purpose of this project was to simulate some different system configurations of a sugar factory, whereby both new and previously used process technologies were utilized. The following parts of the process have been particularly emphasized: Power House - gas turbine, waste heat boiler. Drying - low-temperature dryer, steam dryer. Evaporation - vapour recompression. Crystallization - vapour recompression, continuous system. The different plant configurations have been compared to a reference factory, which is designed according to current technology used in a modern and well balanced Swedish factory. The comparisons are based upon the total power consumption as well as the total annual energy costs. Eleven different plant configurations were studied. The maximum power reduction is 36%, relative to the reference factory. The dissertation also contains an experimental study of a low-temperature drying process. The drying characteristics of pressed beet pulp were studied in a specially designed rotary dryer pilot plant. A number of parameters were varied i.e. the solid moisture content, air velocity, temperature and rotational speed. The results are given in terms of an apparent volumetric heat-transfer coefficient, determined from measured data. A mathematical model was established to determine the residence time of the material in the rotary dryer at different air velocities. (45 refs.).

  10. Cyanobacteria as Cell Factories to Produce Plant Secondary Metabolites

    OpenAIRE

    Xue, Yong; He, Qingfang

    2015-01-01

    Cyanobacteria represent a promising platform for the production of plant secondary metabolites. Their capacity to express plant P450 proteins, which have essential functions in the biosynthesis of many plant secondary metabolites, makes cyanobacteria ideal for this purpose, and their photosynthetic capability allows cyanobacteria to grow with simple nutrient inputs. This review summarizes the advantages of using cyanobacteria to transgenically produce plant secondary metabolites. Some techniq...

  11. A Graphical Interactive Simulation Environment for Production Planning in Bacon Factories

    DEFF Research Database (Denmark)

    Nielsen, Kirsten Mølgaard; Nielsen, Jens Frederik Dalsgaard

    1994-01-01

    The paper describes a graphical interactive simulation tool for production planning in bacon factories........The paper describes a graphical interactive simulation tool for production planning in bacon factories.....

  12. Assessment of Work Zone Noise Levels at a Cement Factory in ...

    African Journals Online (AJOL)

    Assessment of Work Zone Noise Levels at a Cement Factory in Tanga, Tanzania. ... measured in most production sections exceeded the allowed limit value of 85 ... Keywords: Noise levels, Noise exposure, Cement factory, Survey, Tanzania ...

  13. Technology and Participation in Japanese Factories: The Consequences for Morale and Productivity.

    Science.gov (United States)

    Hull, Frank; Azumi, Koya

    1988-01-01

    By fully using their human resources, Japanese factories mass produce goods of low cost and high quality. Participation in Japanese factories occurs in a more hierarchical framework than advocated in the Western model of worker democracy. (JOW)

  14. On the batch cut and products quality procedures in multi-product pipelines; Corte de interfaces e integridade de produtos em polidutos e terminais

    Energy Technology Data Exchange (ETDEWEB)

    Tepedino, A [TRANSPETRO - PETROBRAS Transportes, Rio de Janeiro, RJ (Brazil); Baptista, R M [PETROBRAS, Rio de Janeiro, RJ (Brazil); Rachid, F B Freitas; Araujo, J.H.Carneiro de [Universidade Federal Fluminense, Niteroi, RJ (Brazil)

    2005-07-01

    The increasing complexity in specifying the quality of petroleum products has a great impact on the way it is transported in pipelines so as to avoid degradation and contamination. This work aims to presenting a global and preliminary approach about the transport of petroleum products in batches in pipelines and in multi-product terminal lines towards its automation. Emphasis is placed on the batch formation and batch cut procedures, as well as on the features associated with the installation and instrumentation required to perform this task. The main factors responsible for increasing the mixing volume in batch transfers and for threatening the integrity of the products are highlighted. Several effective measures are pointed out to minimize the mixing volume generation. Among other benefits, they can promote reduction in the cost of transportation and in the amount of degraded products, simplified operational procedures and a minimum need for stocks to cope with its logistic. (author)

  15. Fenarimol, a Pyrimidine-Type Fungicide, Inhibits Brassinosteroid Biosynthesis

    Directory of Open Access Journals (Sweden)

    Keimei Oh

    2015-07-01

    Full Text Available The plant steroid hormone brassinosteroids (BRs are important signal mediators that regulate broad aspects of plant growth and development. With the discovery of brassinoazole (Brz, the first specific inhibitor of BR biosynthesis, several triazole-type BR biosynthesis inhibitors have been developed. In this article, we report that fenarimol (FM, a pyrimidine-type fungicide, exhibits potent inhibitory activity against BR biosynthesis. FM induces dwarfism and the open cotyledon phenotype of Arabidopsis seedlings in the dark. The IC50 value for FM to inhibit stem elongation of Arabidopsis seedlings grown in the dark was approximately 1.8 ± 0.2 μM. FM-induced dwarfism of Arabidopsis seedlings could be restored by brassinolide (BL but not by gibberellin (GA. Assessment of the target site of FM in BR biosynthesis by feeding BR biosynthesis intermediates indicated that FM interferes with the side chain hydroxylation of BR biosynthesis from campestanol to teasterone. Determination of the binding affinity of FM to purified recombinant CYP90D1 indicated that FM induced a typical type II binding spectrum with a Kd value of approximately 0.79 μM. Quantitative real-time PCR analysis of the expression level of the BR responsive gene in Arabidopsis seedlings indicated that FM induces the BR deficiency in Arabidopsis.

  16. KUSTANNUS JA KANNATTAVUUSLASKENNAN KEHITTÄMINEN CASE KOTEK FACTORY SERVICE OY

    OpenAIRE

    Ilmonen, Hanna

    2009-01-01

    Opinnäytetyön toimeksiantajana oli Kotek Factory Service Oy ja kohteena oli Kotek Factory Service Oy:n maalaamo. Kotek Factory Service on Chesterton ARC- pinnoitteiden maahantuoja ja myyjä, joka vastaa tuotteidensa erilaisista urakoinneista, täydellisinä palvelukokonaisuuksina. Opinnäytetyön tavoitteena oli saada aikaiseksi toimintaehdotus siitä, kuinka Kotek Factory Service Oy voisi kehittää kustannus ja kannattavuuslaskentaansa maalaamon ja koko yrityksen osalta. Ongelmaan haettiin ratk...

  17. Regulation of Strigolactone Biosynthesis by Gibberellin Signaling.

    Science.gov (United States)

    Ito, Shinsaku; Yamagami, Daichi; Umehara, Mikihisa; Hanada, Atsushi; Yoshida, Satoko; Sasaki, Yasuyuki; Yajima, Shunsuke; Kyozuka, Junko; Ueguchi-Tanaka, Miyako; Matsuoka, Makoto; Shirasu, Ken; Yamaguchi, Shinjiro; Asami, Tadao

    2017-06-01

    Strigolactones (SLs) are a class of plant hormones that regulate diverse physiological processes, including shoot branching and root development. They also act as rhizosphere signaling molecules to stimulate the germination of root parasitic weeds and the branching of arbuscular mycorrhizal fungi. Although various types of cross talk between SLs and other hormones have been reported in physiological analyses, the cross talk between gibberellin (GA) and SLs is poorly understood. We screened for chemicals that regulate the level of SLs in rice ( Oryza sativa ) and identified GA as, to our knowledge, a novel SL-regulating molecule. The regulation of SL biosynthesis by GA is dependent on the GA receptor GID1 and F-box protein GID2. GA treatment also reduced the infection of rice plants by the parasitic plant witchers weed ( Striga hermonthica ). These data not only demonstrate, to our knowledge, the novel plant hormone cross talk between SL and GA, but also suggest that GA can be used to control parasitic weed infections. © 2017 American Society of Plant Biologists. All Rights Reserved.

  18. Estrogen biosynthesis in human uterine adenomyosis

    International Nuclear Information System (INIS)

    Urabe, Mamoru; Yamamoto, Takara; Kitawaki, Jo; Honjo, Hideo; Okada, Hiroji

    1989-01-01

    Estrogen biosynthesis (aromatiase activity) was investigated in human adenomyosis tissue and compared with that of the normal myometrium, endometrium, and endometrical cancer tissues. Homogenates were incubated with [1,2,6,7- 3 H]androstenedione and NADPH at 37 deg. C for 1 h. After stopping the enzymatic reaction with ethyl acetate, [4- 14 C]estrone and [4- 14 C]estradiol-17β were added to the incubated sample. Estrone and estradiol were purified and identified by Bio-Rad AG1-X2 column chromatography, thin-layer chromatography and co-crystallization. Estrogen formed in the incubated sample was calculated from the 3 H/ 14 C ratio of the final crystal. The value for estrone formed from androstenedione was 52-132 fmol . h -1. g -1 wet weight. Aromatase activity in the adenomyosis tissues was higher than that in normal endometrial or myometrial tissues, but lower than that found in myometrial or endometrial tumour tissue. Furthermore, we investigated the effect of danazol, progresterone, and medroxyprogesterone acetate on adenomyosis cells in primary cultures. Aromatase activity in adenomyosis was blocked by danazol, but stimulated by progesterone and MPA. These results indicate that aromatase activity in adenomyosis may contribute to the growth of the ectopic endometrial tissue which occurs in this disease. (author)

  19. A Biotin Biosynthesis Gene Restricted to Helicobacter

    Science.gov (United States)

    Bi, Hongkai; Zhu, Lei; Jia, Jia; Cronan, John E.

    2016-01-01

    In most bacteria the last step in synthesis of the pimelate moiety of biotin is cleavage of the ester bond of pimeloyl-acyl carrier protein (ACP) methyl ester. The paradigm cleavage enzyme is Escherichia coli BioH which together with the BioC methyltransferase allows synthesis of the pimelate moiety by a modified fatty acid biosynthetic pathway. Analyses of the extant bacterial genomes showed that bioH is absent from many bioC-containing bacteria and is replaced by other genes. Helicobacter pylori lacks a gene encoding a homologue of the known pimeloyl-ACP methyl ester cleavage enzymes suggesting that it encodes a novel enzyme that cleaves this intermediate. We isolated the H. pylori gene encoding this enzyme, bioV, by complementation of an E. coli bioH deletion strain. Purified BioV cleaved the physiological substrate, pimeloyl-ACP methyl ester to pimeloyl-ACP by use of a catalytic triad, each member of which was essential for activity. The role of BioV in biotin biosynthesis was demonstrated using a reconstituted in vitro desthiobiotin synthesis system. BioV homologues seem the sole pimeloyl-ACP methyl ester esterase present in the Helicobacter species and their occurrence only in H. pylori and close relatives provide a target for development of drugs to specifically treat Helicobacter infections. PMID:26868423

  20. Explorations into the biosynthesis of bioscorine

    International Nuclear Information System (INIS)

    Michelson, R.H.

    1988-01-01

    The biosynthesis of dioscorine in Dioscorea hispida has been studied by the feeding of putative precursors labelled at specific positions with 2 H, 3 H, and 14 C. Administration of [3- 14 C]3-hydroxy-3-methylglutaric acid to D. hispida by the wick method afforded dioscorine labelled preferentially at the C 10 position implying that the biosynthetic pathway to the acetate-derived half of the dioscorine skeleton is going through this compound. Administration of ethyl [6- 14 C]orsellinate to D. hispida by the wick method failed to give an appreciable incorporation into dioscroine thereby disproving an alternative mechanism describing the formation of the acetate-derived half of the dioscorine skeleton. Two attempts to simulate the alternative mechanism by oxidatively cleaving ethyl orsellinate also failed, further disfavoring this mechanism. Administration of [2,3] 13 C 2 , 14 C 2 succinic acid, [3- 14 C]aspartic acid and [7a- 14 C]tryptophan by the leaf painting method gave very low incorporations into dioscorine making determination of the source of the nicotinic acid half of the dioscorine skeleton inconclusive. Administration of [6- 2 H, 3 H]nicotinic acid to D. hispida by the wick method afforded dioscorine exhibiting complete retention of 3 H thereby disfavoring a mechanism involving a 3,6-dihydropyridine intermediate in the formation of the dioscorine skeleton

  1. Transcriptional analysis of apple fruit proanthocyanidin biosynthesis

    Science.gov (United States)

    Henry-Kirk, Rebecca A.

    2012-01-01

    Proanthocyanidins (PAs) are products of the flavonoid pathway, which also leads to the production of anthocyanins and flavonols. Many flavonoids have antioxidant properties and may have beneficial effects for human health. PAs are found in the seeds and fruits of many plants. In apple fruit (Malus × domestica Borkh.), the flavonoid biosynthetic pathway is most active in the skin, with the flavan-3-ols, catechin, and epicatechin acting as the initiating units for the synthesis of PA polymers. This study examined the genes involved in the production of PAs in three apple cultivars: two heritage apple cultivars, Hetlina and Devonshire Quarrenden, and a commercial cultivar, Royal Gala. HPLC analysis shows that tree-ripe fruit from Hetlina and Devonshire Quarrenden had a higher phenolic content than Royal Gala. Epicatechin and catechin biosynthesis is under the control of the biosynthetic enzymes anthocyanidin reductase (ANR) and leucoanthocyanidin reductase (LAR1), respectively. Counter-intuitively, real-time quantitative PCR analysis showed that the expression levels of Royal Gala LAR1 and ANR were significantly higher than those of both Devonshire Quarrenden and Hetlina. This suggests that a compensatory feedback mechanism may be active, whereby low concentrations of PAs may induce higher expression of gene transcripts. Further investigation is required into the regulation of these key enzymes in apple. Abbreviations:ANOVAanalysis of varianceANRanthocyanidin reductaseDADdiode array detectorDAFBdays after full bloomDFRdihydroflavonol reductaseLARleucoanthocyanidin reductaseLC-MSliquid chromatography/mass spectrometryPAproanthocyanidinqPCRreal-time quantitative PCR PMID:22859681

  2. The regulation and biosynthesis of antimycins

    Directory of Open Access Journals (Sweden)

    Ryan F. Seipke

    2013-11-01

    Full Text Available Antimycins (>40 members were discovered nearly 65 years ago but the discovery of the gene cluster encoding antimycin biosynthesis in 2011 has facilitated rapid progress in understanding the unusual biosynthetic pathway. Antimycin A is widely used as a piscicide in the catfish farming industry and also has potent killing activity against insects, nematodes and fungi. The mode of action of antimycins is to inhibit cytochrome c reductase in the electron transport chain and halt respiration. However, more recently, antimycin A has attracted attention as a potent and selective inhibitor of the mitochondrial anti-apoptotic proteins Bcl-2 and Bcl-xL. Remarkably, this inhibition is independent of the main mode of action of antimycins such that an artificial derivative named 2-methoxyantimycin A inhibits Bcl-xL but does not inhibit respiration. The Bcl-2/Bcl-xL family of proteins are over-produced in cancer cells that are resistant to apoptosis-inducing chemotherapy agents, so antimycins have great potential as anticancer drugs used in combination with existing chemotherapeutics. Here we review what is known about antimycins, the regulation of the ant gene cluster and the unusual biosynthetic pathway.

  3. Engineering bacteria for enhanced polyhydroxyalkanoates (PHA biosynthesis

    Directory of Open Access Journals (Sweden)

    Guo-Qiang Chen

    2017-09-01

    Full Text Available Polyhydroxyalkanoates (PHA have been produced by some bacteria as bioplastics for many years. Yet their commercialization is still on the way. A few issues are related to the difficulty of PHA commercialization: namely, high cost and instabilities on molecular weights (Mw and structures, thus instability on thermo-mechanical properties. The high cost is the result of complicated bioprocessing associated with sterilization, low conversion of carbon substrates to PHA products, and slow growth of microorganisms as well as difficulty of downstream separation. Future engineering on PHA producing microorganisms should be focused on contamination resistant bacteria especially extremophiles, developments of engineering approaches for the extremophiles, increase on carbon substrates to PHA conversion and controlling Mw of PHA. The concept proof studies could still be conducted on E. coli or Pseudomonas spp. that are easily used for molecular manipulations. In this review, we will use E. coli and halophiles as examples to show how to engineer bacteria for enhanced PHA biosynthesis and for increasing PHA competitiveness.

  4. Biosynthesis of myristic acid in luminescent bacteria

    International Nuclear Information System (INIS)

    Byers, D.M.

    1987-01-01

    In vivo pulse-label studies have demonstrated that luminescent bacteria can provide myritic acid (14:0) required for the synthesis of the luciferase substrate myristyl aldehyde. Luminescent wild type Vibrio harveyi incubated with [ 14 C] acetate in a nutrient-depleted medium accumulated substantial tree [ 14 C]fatty acid (up to 20% of the total lipid label). Radio-gas chromatography revealed that > 75% of the labeled fatty acid is 14:0. No free fatty acid was detected in wild type cells labeled prior to the development of bioluminescence in the exponential growth phase, or in a dark mutant of V. harveyi (mutant M17) that requires exogenous 14:0 for light emission. The preferential accumulation of 14:0 was not observed when wild type cells were labeled with [ 14 C]acetate in regular growth medium. Moreover, all V. harveyi strains exhibited similar fatty acid mass compositions regardless of the state of bioluminescence. Since earlier work has shown that a luminescence-related acyltransferase (defective in the M17 mutant) can catalyze the deacylation of fatty acyl-acyl carrier protein in vitro, the present results are consistent with a model in which this enzyme diverts 14:0 to the luminescence system during fatty acid biosynthesis. Under normal conditions, the supply of 14:0 by this pathway is tightly regulated such that bioluminescence development does not significantly alter the total fatty acid composition

  5. Biosynthesis of plasmenylcholine in guinea pig heart

    International Nuclear Information System (INIS)

    Wientzek, M.; Choy, P.C.

    1986-01-01

    In some mammalian hearts, up to 40% of the choline phosphoglyceride (CPG) exists as plasmenylcholine (1-alkenyl-2-acyl-glycero-3-phosphocholine). Although the majority of diacylphosphatidylcholine (PC) in mammalian hearts is synthesized from choline via the CDP-choline pathway, the formation of plasmenylcholine from choline was not known. In this study, they investigated the biosynthesis of plasmenyl-choline in the isolated guinea pig heart by perfusion with [ 3 H]choline. Labelled choline containing metabolites and labelled plasmenylcholine were isolated and determined at different perfusion time points. Significant amounts of labelling were found only in choline, phosphocholine, CDP-choline, plasmenyl-choline and PC. In addition, a precursor-product relationship was observed between the labelling of CDP-choline and plasmenylcholine. Such a relationship was not observed between choline and plasmenylcholine. Hence, they postulate that the incorporation of choline into plasmenylcholine is via the CDP-choline pathway and not via base exchange. The ability to condense 1-alkenyl-2-acyl-glycerol with CDP-choline was also demonstrated in vitro with guinea pig heart microsomes

  6. Biosynthesis of secondary metabolites in sugarcane

    Directory of Open Access Journals (Sweden)

    S.C. França

    2001-12-01

    Full Text Available A set of genes related to secondary metabolism was extracted from the sugarcane expressed sequence tag (SUCEST database and was used to investigate both the gene expression pattern of key enzymes regulating the main biosynthetic secondary metabolism pathways and the major classes of metabolites involved in the response of sugarcane to environmental and developmental cues. The SUCEST database was constructed with tissues in different physiological conditions which had been collected under varied situation of environmental stress. This database allows researchers to identify and characterize the expressed genes of a wide range of putative enzymes able to catalyze steps in the phenylpropanoid, isoprenoid and other pathways of the special metabolic mechanisms involved in the response of sugarcane to environmental changes. Our results show that sugarcane cDNAs encoded putative ultra-violet induced sesquiterpene cyclases (SC; chalcone synthase (CHS, the first enzyme in the pathway branch for flavonoid biosynthesis; isoflavone synthase (IFS, involved in plant defense and root nodulation; isoflavone reductase (IFR, a key enzyme in phenylpropanoid phytoalexin biosynthesis; and caffeic acid-O-methyltransferase, a key enzyme in the biosynthesis of lignin cell wall precursors. High levels of CHS transcripts from plantlets infected with Herbaspirillum rubri or Gluconacetobacter diazotroficans suggests that agents of biotic stress can elicit flavonoid biosynthesis in sugarcane. From this data we have predicted the profile of isoprenoid and phenylpropanoid metabolism in sugarcane and pointed the branches of secondary metabolism activated during tissue-specific stages of development and the adaptive response of sugarcane to agents of biotic and abiotic stress, although our assignment of enzyme function should be confirmed by careful biochemical and genetic supporting evidence.Este trabalho foi realizado com os objetivos de gerar uma coleção de genes

  7. Tyrosine biosynthesis, metabolism, and catabolism in plants.

    Science.gov (United States)

    Schenck, Craig A; Maeda, Hiroshi A

    2018-05-01

    L-Tyrosine (Tyr) is an aromatic amino acid (AAA) required for protein synthesis in all organisms, but synthesized de novo only in plants and microorganisms. In plants, Tyr also serves as a precursor of numerous specialized metabolites that have diverse physiological roles as electron carriers, antioxidants, attractants, and defense compounds. Some of these Tyr-derived plant natural products are also used in human medicine and nutrition (e.g. morphine and vitamin E). While the Tyr biosynthesis and catabolic pathways have been extensively studied in microbes and animals, respectively, those of plants have received much less attention until recently. Accumulating evidence suggest that the Tyr biosynthetic pathways differ between microbes and plants and even within the plant kingdom, likely to support the production of lineage-specific plant specialized metabolites derived from Tyr. The interspecies variations of plant Tyr pathway enzymes can now be used to enhance the production of Tyr and Tyr-derived compounds in plants and other synthetic biology platforms. Copyright © 2018 Elsevier Ltd. All rights reserved.

  8. Glycoprotein biosynthesis by human normal platelets

    International Nuclear Information System (INIS)

    Rodriguez, P.; Bello, O.; Apitz-Castro, R.

    1987-01-01

    Incorporation of radioactive Man, Gal, Fuc, Glc-N, and NANA into washed human normal platelets and endogenous glycoproteins has been found. Both parameters were time dependent. Analysis of hydrolyzed labeled glycoproteins by paper chromatography revealed that the radioactive monosaccharide incubated with the platelets had not been converted into other sugars. Acid hydrolysis demonstrates the presence of a glycosidic linkage. All the effort directed to the demonstration of the existence of a lipid-sugar intermediate in intact human platelets yielded negative results for Man and Glc-N used as precursors. The incorporation of these sugars into glycoproteins is insensitive to bacitracin, suggesting no involvement of lipid-linked saccharides in the synthesis of glycoproteins in human blood platelets. The absence of inhibition of the glycosylation process in the presence of cycloheximide suggests that the sugars are added to proteins present in the intact platelets. These results support the contention that glycoprotein biosynthesis in human blood platelets observed under our experimental conditions is effected through direct sugar nucleotide glycosylation

  9. Preliminary studies of the biosynthesis of Austin

    International Nuclear Information System (INIS)

    Wicnienski, N.A.

    1979-01-01

    Aspergillus ustus is one of the most prevalent fungi in the soil. There are now two reports of the occurrence of toxin-producing strains of this fungus on stored foodstuffs. In addition, strains of A. ustus have been isolated along with Penicillium species from samples of South African cheeses. All A. ustus isolates tested were judged to be highly toxic to ducklings when grown on maize meal, however, the toxins involved were not isolated. Austin is the trivial name of one of the toxins made by the fungus found on stored food. Preliminary work to studying the biosynthesis of this compound using 13 C-labeled sodium acetate is reported here. The feasibility of the biosynthetic study was determined by feeding [1- 14 C]-sodium acetate to A. ustus cultures. The assignments made in the 13 C-nmr spectrum of Austin are shown. The lowest dilution factor obtained in [1- 14 C]-sodium acetate feeding experiments was 14. This dilution factor is sufficiently low to allow a successful feeding of [1,2- 13 C 2 ]-sodium acetate. A new metabolite of A. ustus, deacetylaustin, was isolated and identified. An alkaloid of unknown structure was also isolated from the fungus

  10. Proceedings of the 2-nd workshop on JINR tau-charm factory

    International Nuclear Information System (INIS)

    Aleksandrov, V.S.; Perel'shtejn, E.A.

    1993-01-01

    Application of tau-charm factory for investigation of hadronic decay and charged leptonic weak interaction is considered. JINR tau-charm-factory design and magnetic and vacuum systems of the booster ring are described. New types of silicon microstrip detector sand BGO-counters developed for tau-charm-factory are proposed

  11. Bulgar Factories (Trading Posts) in the Kama River Area as a Factor of Adjustment to Feudalism

    Science.gov (United States)

    Krylasova, Natalia B.; Belavin, Andrei M.; Podosenova, Yulia A.

    2016-01-01

    At the start of the 2nd ML AD a number of trading posts, or factories, emerged in the Cis-Ural region with participation of Bulgar handicraftsmen and merchants. They were townships populated by various ethnic groups. Several centuries later similar factories were set up by natives of the Cis-Ural region in Western Siberia. These factories have…

  12. 76 FR 77175 - New York Fun Factory Fireworks Display, Western Long Island Sound; Mamaroneck, NY

    Science.gov (United States)

    2011-12-12

    ...-AA00 New York Fun Factory Fireworks Display, Western Long Island Sound; Mamaroneck, NY AGENCY: Coast... in support of the New York Fun Factory Fireworks display. This action is necessary to provide for the... the Coast Guard to define regulatory safety zones. On May 10, 2012 New York Fun Factory Events is...

  13. The Operator Guide: An Ambient Persuasive Interface in the Factory

    Science.gov (United States)

    Meschtscherjakov, Alexander; Reitberger, Wolfgang; Pöhr, Florian; Tscheligi, Manfred

    In this paper we introduce the context of a semiconductor factory as a promising area for the application of innovative interaction approaches. In order to increase efficiency ambient persuasive interfaces, which influence the operators' behaviour to perform in an optimized way, could constitute a potential strategy. We present insights gained from qualitative studies conducted in a specific semiconductor factory and provide a description of typical work processes and already deployed interfaces in this context. These findings informed the design of a prototype of an ambient persuasive interface within this realm - the "Operator Guide". Its overall aim is to improve work efficiency, while still maintaining a minimal error rate. We provide a detailed description of the Operator Guide along with an outlook of the next steps within a user-centered design approach.

  14. Cell Factory Stability and Genetic Circuits for Improved Strain Development

    DEFF Research Database (Denmark)

    Rugbjerg, Peter

    . However, all synthetic gene systems -­ including the target metabolic pathways themselves -­ represent a possible fitness burden to the cell and thus constitute a threat to strain stability. In this thesis, several studies served to develop genetic systems for optimizing cell factory development...... systems can challenge the stability of strain designs. A metabolite-­producing Escherichia coli strain was long-­term cultured to study production stability and the dynamic effects of mutations within the cell population. A genetic error landscape of pathway disruptions was identified including particular......Development of new chemical-­‐producing microbial cell factories is an iterative trial-­and-­error process, and to screen candidate cells at high throughput, genetic biosensor systems are appealing. Each biosensor has distinct biological parameters, making modular tuning networks attractive...

  15. High-current proton accelerators-meson factories

    International Nuclear Information System (INIS)

    Dmitrievskij, V.P.

    1979-01-01

    A possibility of usage of accelerators of neutron as well as meson factories is considered. Parameters of linear and cyclic accelerators are given, which are employed as meson factories and as base for developing intense neutron generators. It is emphasized that the principal aim of developing neutron generators on the base of high current proton accelerators is production of intense neutron fluxes with a present energy spectrum. Production of tens-and-hundreds milliampere currents at the energy of 800-1000 MeV is considered at present for two types of accelerating facilities viz. linear accelerators under continuous operating conditions and cyclotrons with strong focusing. Quantitative evaluations of developing high-efficiency linear and cyclic accelerators are considered. The basic parameters of an ccelerating complex are given, viz. linear accelerator-injector and 800 MeV isochronous cyclotron. The main problems associated with their realization are listed [ru

  16. Collimation issues for the PEP-II B-factory

    International Nuclear Information System (INIS)

    Sullivan, M.

    1997-12-01

    This note describes how beam collimation affects detector backgrounds at the collision point for the PEP-II B-factory, a joint effort of three laboratories: LBNL, LLNL, and SLAC. Beam collimation controls the transverse size as well as the maximum allowed energy spread of the beam. The location of synchrotron radiation masks is determined by the transverse size of the beam in that the masks must prevent radiation generated by beam particles located at large transverse beam positions from directly striking the detector beam pipe. Collimation of the energy spread of the beam is important in the control of backgrounds produced by beam particles that strike a gas molecule (lost beam particles). The author describes some preliminary information from background studies during the first months of commissioning the high energy ring of the PEP-II B-factory and present some model predictions for synchrotron radiation backgrounds when collimators are not present

  17. Eficiency factory - Quo Vadis? Brief study; Effizienzfabrik - Quo Vadis? Kurzstudie

    Energy Technology Data Exchange (ETDEWEB)

    Mattes, Katharina; Kleine, Oliver; Hirzel, Simon; Rhode, Clemens

    2012-11-15

    The demand for an enhanced resource efficiency and energy efficiency in production arises not only from a purely economic perspective, but also from environmental and social reasons. Nevertheless, the issue of resource efficiency did not gain the necessary attention at the corporate level. In 2009, the Federal Ministry of Education and Research (Berlin, Federal Republic of Germany) launched a program to develop resource-efficient production technologies in which 31 integrated research projects with the efficiency factory and a dedicated accompanying project are promoted immediately in order to improve the transfer of the results. The contribution under consideration reports on the performance of the efficiency factory as a transfer platform in the context of the funding priority and the research results achieved up to now.

  18. Team table: a framework and tool for continuous factory planning

    Science.gov (United States)

    Sihn, Wilfried; Bischoff, Juergen; von Briel, Ralf; Josten, Marcus

    2000-10-01

    Growing market turbulences and shorter product life cycles require a continuous adaptation of factory structures resulting in a continuous factory planning process. Therefore a new framework is developed which focuses on configuration and data management process integration. This enable an online system performance evaluation based on continuous availability of current data. The use of this framework is especially helpful and will guarantee high cost and time savings, when used in the early stages of the planning, called the concept or rough planning phase. The new framework is supported by a planning round table as a tool for team-based configuration processes integrating the knowledge of all persons involved in planning processes. A case study conducted at a German company shows the advantages which can be achieved by implementing the new framework and methods.

  19. Software factory techniques applied to Process Control at CERN

    CERN Multimedia

    Dutour, MD

    2007-01-01

    The CERN Large Hadron Collider (LHC) requires constant monitoring and control of quantities of parameters to guarantee operational conditions. For this purpose, a methodology called UNICOS (UNIfied Industrial COntrols Systems) has been implemented to standardize the design of process control applications. To further accelerate the development of these applications, we migrated our existing UNICOS tooling suite toward a software factory in charge of assembling project, domain and technical information seamlessly into deployable PLC (Programmable logic Controller) – SCADA (Supervisory Control And Data Acquisition) systems. This software factory delivers consistently high quality by reducing human error and repetitive tasks, and adapts to user specifications in a cost-efficient way. Hence, this production tool is designed to encapsulate and hide the PLC and SCADA target platforms, enabling the experts to focus on the business model rather than specific syntaxes and grammars. Based on industry standard software...

  20. Software factory techniques applied to process control at CERN

    CERN Document Server

    Dutour, Mathias D

    2008-01-01

    The CERN Large Hadron Collider (LHC) requires constant monitoring and control of quantities of parameters to guarantee operational conditions. For this purpose, a methodology called UNICOS (UNIfied Industrial COntrols Systems) has been implemented to standardize the design of process control applications. To further accelerate the development of these applications, we migrated our existing UNICOS tooling suite toward a software factory in charge of assembling project, domain and technical information seamlessly into deployable PLC (Programmable logic Controller) - SCADA (Supervisory Control And Data Acquisition) systems. This software factory delivers consistently high quality by reducing human error and repetitive tasks, and adapts to user specifications in a cost-efficient way. Hence, this production tool is designed to encapsulate and hide the PLC and SCADA target platforms, enabling the experts to focus on the business model rather than specific syntaxes and grammars. Based on industry standard software, ...

  1. Integral logistics of the nuclear fuel Factory Juzbado

    International Nuclear Information System (INIS)

    Perez, P.

    2015-01-01

    The Logistic considers the complete process since the determination of possible demand, production planning, materials procurement, production control and delivery of final products to customer. This complete process is managed in all the scope under the same department called Planning and Logistic. This integration, some times really complex, has allowed to Enusa factory control all the key aspects that allow its running completely, considering the synergy's and important advantages to solve different problems. This article describes how we work of the main areas of procurement, production planning and control, fuel delivery and project planning of improvements on equipment's and factory systems, with an integrated management of all of them under the same direction. (Author)

  2. Systems analysis and futuristic designs of advanced biofuel factory concepts.

    Energy Technology Data Exchange (ETDEWEB)

    Chianelli, Russ; Leathers, James; Thoma, Steven George; Celina, Mathias C.; Gupta, Vipin P.

    2007-10-01

    The U.S. is addicted to petroleum--a dependency that periodically shocks the economy, compromises national security, and adversely affects the environment. If liquid fuels remain the main energy source for U.S. transportation for the foreseeable future, the system solution is the production of new liquid fuels that can directly displace diesel and gasoline. This study focuses on advanced concepts for biofuel factory production, describing three design concepts: biopetroleum, biodiesel, and higher alcohols. A general schematic is illustrated for each concept with technical description and analysis for each factory design. Looking beyond current biofuel pursuits by industry, this study explores unconventional feedstocks (e.g., extremophiles), out-of-favor reaction processes (e.g., radiation-induced catalytic cracking), and production of new fuel sources traditionally deemed undesirable (e.g., fusel oils). These concepts lay the foundation and path for future basic science and applied engineering to displace petroleum as a transportation energy source for good.

  3. Design and manufacture NCS instruments for cement factories

    International Nuclear Information System (INIS)

    Nguyen Thanh Tuy; Nguyen Tien Dung; Dang Nguyet Anh; Nguyen Phuc; Khuong Thanh Tuan; Luong Duc Long; Pham Trong Quyen

    2003-01-01

    The ministry project 'Design and manufacture some of NCS instruments for cement factories' is a part of instrumentation for cement production in Vietnam. The objectives of the project include: 1/Design and manufacture the automatic control system for cement raw material mixing, connected to components X-ray analyzer through serial port of PC; 2/Design and manufacture the automatic discharge control system using gamma rays. The instruments, made by the project , for controlling the conveyor belt weighing machine can be easily improved for various types of conveyor belt weighing machines. Their mobility and software equipped can be adapted for requirement of modern cement production technology. The instruments are operating well in some cement factories and they are helping in quality control. (NHA)

  4. Novel Methods for Development of Cell Factories and Laboratory Simultations

    DEFF Research Database (Denmark)

    Bonde, Mads

    engineering. A key part of the transforming towards a biobased society and development of cell factories, is a skilled workforce to address the challenges. Furthermore, new methods need to be accessible to scientists and students in order to impact future research. Part of this challenge can be addressed...... by improving education and making these technologies accessible to students. The second part of the thesis relates to innovative methods for enhancing science education through technology. Traditional teaching methods are dominating science education, but new IT-based approaches provide an opportunity....... However, the lack of foundational technologies, methods, and prediction capabilities form a large barrier towards the transformation to a bio-based society, where products of cell factories are replacing fossil fuels, plastics and traditional chemicals derived from oil. In this thesis we present new...

  5. A large magnetic detector for the neutrino factory

    International Nuclear Information System (INIS)

    Cervera, A.; Dydak, F.; Gomez Cadenas, J.J.

    2000-01-01

    The physics opportunities of the neutrino factory have been the subject of a number of recent studies. It was shown that sensitive measurements of the angle θ 13 , of MSW effects, and of the sign of the atmospheric mass difference Δm 23 2 are possible, and even CP violation in the neutrino mixing matrix may be within reach. The focus of interest is the oscillation ν e →ν μ , which leads in the well-defined neutrino beam of the neutrino factory to 'wrong-sign' muon events. In this paper, we show that a large magnetic detector will be capable of detecting with high efficiency and small backgrounds such wrong-sign muon events. We present a conceptual design of the apparatus and its performance. Various backgrounds are analysed and we demonstrate that they can be sufficiently suppressed by appropriate cuts. We illustrate the performance of the large magnetic detector by its sensitivity to the angle θ 13

  6. SEARCH FOR NEW PHYSICS AT A SUPER-B FACTORY.

    Energy Technology Data Exchange (ETDEWEB)

    BROWDER,T.E.; SONI,A.

    2004-01-05

    The importance of a Super-B Factory in the search for New Physics, in particular, due to CP-od phase(s) from physics beyond the Standard Model is surveyed. The first point to emphasize is that we know now how to directly measure all three angles of the unitarity triangle very cleanly, i. e. without theoretical assumptions with irreducible theory error {le} 1%; however this requires much more luminosity than is currently available at B-factories. Direct searches via penguin-dominated hadronic modes as well as radiative, pair-leptonic and semi-leptonic decays are also discussed. Null tests of the SM are stressed as these will play a crucial role especially if the effects of BSM phase(s) on B-physics are small.

  7. R and D Toward Neutrino Factories and Muon Colliders

    International Nuclear Information System (INIS)

    Zisman, Michael S.

    2003-01-01

    R and D aimed at the production, acceleration, and storage of intense muon beams is under way in the U.S., in Europe, and in Japan. Considerable progress has been made in the past few years toward the design of a ''Neutrino Factory'' in which a beam of 20-50 GeV mu- or mu+ is stored. Decay neutrinos from the beam illuminate a detector located roughly 3000 km from the ring. Here, we briefly describe the ingredients of a Neutrino Factory and then discuss the current R and D program and its results. A key concept in the design is ''ionization cooling,'' a process whereby the muon emittance is reduced by repeated interactions with an absorber material followed by reacceleration with high-gradient rf cavities. Plans to test this concept in the Muon Ionization Cooling Experiment (MICE) are well along and are described briefly

  8. Energy efficiency enhancement in cement factories using expert system

    International Nuclear Information System (INIS)

    Effatnejad, R.; Jadih, S.

    2001-01-01

    Full text : In this paper, expert system for energy efficiency in cement industry is presented. Due to the fact that cement manufacturing project in these factories are similar, so in main parts knowing the consumption origins and save potential and existing approaches can be similar. In this method, via expert system software of prolog AH types of energy consumption and investment costs are listed in which method of best first search and innovative search have been used and by forming knowledge base, targeting to get best approaches is presented. The obtained results, regarding the executed limits, will be displayed in the output of program and this program can be given the best decision about energy management in cement factories

  9. Evaluation of Airborne MDF Dust Concentration in Furniture Factories

    Directory of Open Access Journals (Sweden)

    Renilson Luiz Teixeira

    2017-10-01

    Full Text Available ABSTRACT High concentrations of airborne dust are observed during the cutting of medium density fiberboard (MDF boards. This dust, at first considered just uncomfortable for workers, may be harmful to their health. The objective of this work was to evaluate the concentration of airborne dust during the cutting of medium density fiberboard (MDF. The experiment was developed in the MDF cutting sector of three furniture factories located in the city of Lavras/MG. The results showed that the mean concentrations of total dust suspended in these three furniture factories were above the tolerance limit set by the American Conference of Governmental Industrial Hygienists (ACGIH, giving evidence of a serious problem in these companies related to this type of risk agent.

  10. Unifying logarithmic and factorial behavior in high-energy scattering

    International Nuclear Information System (INIS)

    Cornwall, J.M.; Morris, D.A.

    1995-01-01

    The elegant instanton calculus of Lipatov and others used to find factorially divergent behavior (g N N exclamation point) for N g much-gt 1 in gφ 4 perturbation theory is strictly only applicable when all external momenta vanish; a description of high-energy 2→N scattering with N massive particles is beyond the scope of such techniques. On the other hand, a standard multiperipheral treatment of scattering with its emphasis on leading logarithms gives a reasonable picture of high-energy behavior but does not result in factorial divergences. Using a straightforward graphical analysis we present a unified picture of both these phenomena as they occur in the two-particle total cross section of gφ 4 theory. We do not attempt to tame the unitarity violations associated with either multiperipheralism or the Lipatov technique at strong coupling

  11. R and D Toward a Neutrino Factory and Muon Collider

    International Nuclear Information System (INIS)

    Zisman, Michael S.

    2009-01-01

    There is considerable interest in the use of muon beams to create either an intense source of decay neutrinos aimed at a detector located 3000-7500 km away (a Neutrino Factory), or a Muon Collider that produces high-luminosity collisions at the energy frontier. R and D aimed at producing these facilities has been under way for more than 10 years. This paper will review experimental results from MuCool, MERIT, and MICE and indicate the extent to which they will provide proof-of-principle demonstrations of the key technologies required for a Neutrino Factory or Muon Collider. Progress in constructing components for the MICE experiment will also be described.

  12. RF field control for Kaon Factory booster cavities

    International Nuclear Information System (INIS)

    Craig, S.T.; de Jong, M.S.

    1992-08-01

    A conceptual design is developed for control of the Kaon Factory booster rf accelerating fields. This design addresses control of cavity: tuning, voltage amplitude, and voltage phase angle. Time-domain simulations were developed to evaluate the proposed controllers. These simulations indicate that adequate tuning performance can be obtained with the combination of adaptive feed forward and proportional feedback control. Voltage amplitude and voltage phase can be adequately controlled using non-adaptive feed forward and proportional feedback control. (Author) (figs., tabs.)

  13. RF field control for KAON Factory booster cavities

    International Nuclear Information System (INIS)

    Craig, S.T.; de Jong, M.S.

    1990-11-01

    A conceptual design is developed for control of the KAON Factory Booster rf accelerating fields. This design addresses control of cavity: tuning, voltage amplitude, and voltage phase angle. Time-domain simulations were developed to evaluated the proposed controllers. These simulations indicated that adequate tuning performance can be obtained with the combination of adaptive feed-forward and proportional feedback control. Voltage amplitude and voltage phase can be adequately controlled using non-adaptive feedforward and proportional feedback control

  14. SatisFactory Common Information Data Exchange Model

    OpenAIRE

    CERTH

    2016-01-01

    This deliverable defines the Common Information Data Exchange Model (CIDEM). The aim of CIDEM is to provide a model of information elements (e.g. concepts, even, relations, interfaces) used for information exchange between components as well as for modelling work performed by other tasks (e.g. knowledge models to support human resources optimization). The CIDEM definition is considered as a shared vocabulary that enables to address the information needs for the SatisFactory framework components.

  15. Feedback implementation options and issues for B factory accelerators

    International Nuclear Information System (INIS)

    Fox, J.D.; Briggs, D.; Eisen, N.; Hindi, H.; Hosseini, W.; Oxoby, G.; Linscott, I.; Coiro, O.; Ghigo, A.; Serio, M.; Lambertson, G.; Voelker, F.

    1992-09-01

    The proposed B factory accelerator facilities will require active feedback systems to control multibunch instabilities. These feedback systems must operate in machines with thousands of circulating bunches and with short (2--4 ns) interbunch intervals. The functional requirements for transverse (betatron) and longitudinal (synchrotron) feedback systems are presented. Several possible implementation options are discussed and system requirements developed. Conceptual designs are presented for the PEP II transverse and longitudinal feedback systems

  16. Superintensive pulse slow neutron source SIN based on kaon factory

    International Nuclear Information System (INIS)

    Kolmichkov, N.V.; Laptev, V.D.; Matveev, V.A.

    1991-01-01

    Possibility of intensive pulse slow neutron source creation based on 45-GeV proton synchrotron of K-meson factory, planned to construction in INR AS USSR is considered. Calculated peak thermal neutrons flux density value, averaged on 'radiating' light-water moderator surface of 100 cm 2 is 6.6 x 10 17 neutrons/(cm 2 sec) for pulse duration of 35 microseconds. (author)

  17. Power supply system for the TRIUMF KAON factory

    International Nuclear Information System (INIS)

    Reiniger, K.W.

    1991-05-01

    The TRIUMF KAON Factory consists of 5 rings, 3 of which are dc powered and 2 synchrotrons running at 50 Hz and 10 Hz, respectively. This paper deals with the power supply system envisaged for the accelerator as well as the experimental results obtained using dc-biased single and dual frequency resonant magnet excitation for the booster and driver synchrotrons. (Author) 6 refs., 8 figs

  18. The program of continuous improvements in factory in Juzbado

    International Nuclear Information System (INIS)

    Prieto, M.

    2015-01-01

    This articles describes the historical development of the continuous improvement program at Juzbado Factory, since its beginning to nowadays. The evolution throughout the ideas of Total Quality, ISO, EFQM, Six Sigma, and so on, leading to the present situation in which all these tools and methodologies live together is shown. all this has led to a philosophy and business culture focused on safety, quality and continuous improvement. (Author)

  19. Comments on particle identification at the B factory

    International Nuclear Information System (INIS)

    Ratcliff, B.N.

    1992-01-01

    The importance of particle identification at an asymmetric B Factory is discussed, and the general status of a number of particle identification technologies which might be included in B Factory detectors is briefly reviewed. It is generally agreed that high quality hadronic particle identification is fundamental to the central mission of understanding CP violation at the B Factory, but there is as yet no clear open-quotes consensusclose quotes solution for such a detector. In a sense, this lack of a particle identification solution is a matter of definition. There is, in fact, a perfectly reasonable, open-quotes conventional technologyclose quotes, particle identification system which makes use of a large tracking chamber with excellent (i.e., relativistic rise quality) dE/dx surrounded by a good TOF with a rather long flight path. The chamber must be rather large (around 2 meters in outer radius) and perhaps high pressure as well, but similar devices are rather well understood and it would appear to be possible to meet the particle identification performance required at B Factory momenta. This solution has not been embraced by any of the detector groups, however, because of the effect it has on the electromagnetic calorimetry. open-quotes Everyoneclose quotes wants high quality calorimetry (such as can be provided by CsI crystals), but such devices cost a great deal per unit volume, and the cost scales roughly like the inner radius squared. Moreover, no one wants to see the high quality (expensive) calorimetry compromised by excessive mass in front. Thus, the essence of the particle identification problem is that there is no approximately massless, very thin particle identification device known with adequate performance. Of course, it might equally well be said that there is no high quality calorimeter known which is sufficiently cost-effective to be placed outside an appropriately sized tracking plus particle identification system

  20. RF system design for the PEP-II B Factory

    International Nuclear Information System (INIS)

    Schwarz, H.; Rimmer, R.

    1994-06-01

    The paper presents an overview of the design of the RF system for the PEP-II B Factory. An RF station consists of either two or four single-cell cavities driven by a 1.2 MW klystron through a waveguide distribution network. A variety of feedback loops stabilize the RF and its interaction with the beam. System parameters and all the relevant parameters of klystron and cavities are given

  1. Survey and alignment of photon factory storage ring at KEK

    International Nuclear Information System (INIS)

    Araki, A.; Honjo, I.; Katoh, M.; Kamiya, Y.; Kihara, M.

    1987-01-01

    The heights of the magnets for both the ring and the beam transport line (BT-line) have been periodically measured at the Photon Factory. The accumulated data showed that the ring was considerably declined due to the construction of the large experimental hall and the tunnel of the TRISTAN project, and that the BT-line also sank several centimeters at some locations. These displacements of the magnets produce a significantly large closed orbit distortion and the vertical dispersion

  2. Synchrotron radiation leakage from the B-factory beam pipe

    International Nuclear Information System (INIS)

    Jenkins, T.M.; Nelson, W.R.; Ipe, N.

    1990-01-01

    The high-energy ring (HER) of the B-Factory, running at an energy of 9 GeV, generates the synchrotron spectrum when applied to a ring with the PEP bending radius. The B-Factory HER may also run at 12 GeV, producing the harder spectrum. Depending upon beam-pipe material and thickness, some of this radiation may escape and deposit energy in the surrounding material. This was originally pointed out in PEP-109 during the initial design of PEP, and subsequently verified by measurements at both PEP and PETRA at DESY. Of concern to the B Factory is magnet insulation, though other adjacent materials such as wire insulation and cooling water hoses are even more radiosensitive. Radiation damage to magnets is a function of the type of material used in the potting compound. The PEP magnets, which hopefully can be used for the high-energy ring of the B-Factory, are insulated with an epoxy composed of DER-332, DER-732, NMA and aluminum oxide. It is estimated that this epoxy compound should tolerate doses near the 10 10 rad range. To summarize the results of these calculations, 0.87 cm of copper is needed at the point of maximum dose from 12-GeV operation in order to reach the dose criterion if a rectangular beam pipe is used. The copper needs to be only 0.7-cm thick for an octagonal beam pipe and the same energy. For 9-GeV operation, an octagonal copper pipe needs only to be 0.25-cm thick. An octagonal aluminum pipe that is 0.5-cm thick also needs 0.3 cm of lead on the outside to reach the same criterion for 12-GeV operation. For 9-GeV operation, the aluminum pipe still requires a lead liner

  3. An asymmetric B-meson factory at PEP

    International Nuclear Information System (INIS)

    Garren, A.; Chattopadhyay, S.; Chin, Y.; Oddone, P.; Zisman, M.S.; Donald, M.; Feldman, G.; Paterson, J.M.; Rees, J.

    1989-03-01

    A preliminary design for a B-factory has been made using asymmetric collisions between positrons in the PEP storage ring and electrons in a new, log-energy ring. The design utilizes small-aperture, permanent-magnet quadrupoles close to the interaction point (IP). Optimization of optical and beam parameters at the IP will be discussed, as well as the lattice design of the interaction region and of the rings. 7 refs., 3 figs., 2 tabs

  4. Software factory techniques applied to process control at CERN

    OpenAIRE

    Dutour, Mathias D

    2007-01-01

    The CERN Large Hadron Collider (LHC) requires constant monitoring and control of quantities of parameters to guarantee operational conditions. For this purpose, a methodology called UNICOS (UNIfied Industrial COntrols Systems) has been implemented to standardize the design of process control applications. To further accelerate the development of these applications, we migrated our existing UNICOS tooling suite toward a software factory in charge of assembling project, domain and technical inf...

  5. Factory Virtual Environment Development for Augmented and Virtual Reality

    OpenAIRE

    M. Gregor; J. Polcar; P. Horejsi; M. Simon

    2015-01-01

    Machine visualization is an area of interest with fast and progressive development. We present a method of machine visualization which will be applicable in real industrial conditions according to current needs and demands. Real factory data were obtained in a newly built research plant. Methods described in this paper were validated on a case study. Input data were processed and the virtual environment was created. The environment contains information about dimensions, s...

  6. Determinants of Chronic Respiratory Symptoms among Pharmaceutical Factory Workers

    Directory of Open Access Journals (Sweden)

    Sahle Asfaw

    2018-01-01

    Full Text Available Background. Chronic respiratory symptoms including chronic cough, chronic phlegm, wheezing, shortness of breath, and chest pain are manifestations of respiratory problems which are mainly evolved as a result of occupational exposures. This study aims to assess determinants of chronic respiratory symptoms among pharmaceutical factory workers. Methods. A case control study was carried out among 453 pharmaceutical factory workers with 151 cases and 302 controls. Data was collected using pretested and structured questionnaire. The data was analyzed using descriptive statistics and bivariate and multivariate analysis. Result. Previous history of chronic respiratory diseases (AOR = 3.36, 95% CI = 1.85–6.12, family history of chronic respiratory diseases (AOR = 2.55, 95% CI = 1.51–4.32, previous dusty working environment (AOR = 2.26, 95% CI = 1.07–4.78, ever smoking (AOR = 3.66, 95% CI = 1.05–12.72, and service years (AOR = 1.86, 95% CI = 1.16–2.99 showed statistically significant association with chronic respiratory symptoms. Conclusion. Previous history of respiratory diseases, family history of chronic respiratory diseases, previous dusty working environment, smoking, and service years were determinants of chronic respiratory symptoms. Public health endeavors to prevent the burden of chronic respiratory symptoms among pharmaceutical factory workers should target the reduction of adverse workplace exposures and discouragement of smoking.

  7. Optimized Neutrino Factory for small and large θ13

    International Nuclear Information System (INIS)

    Agarwalla, Sanjib Kumar

    2013-01-01

    Recent results from long baseline neutrino oscillation experiments point towards a non-zero value of θ 13 at around 3σ confidence level. In the coming years, further ratification of this result with high significance will have crucial impact on the planning of the future long baseline Neutrino Factory setup aimed to explore leptonic CP violation and the neutrino mass ordering. In this talk, we discuss the baseline and energy optimization of the Neutrino Factory including the latest simulation results on the magnetized iron neutrino detector (MIND) in the light of both small and large θ 13 . We find that in case of small θ 13 , baselines of about 2500 to 5000 km is the optimal choice for the CP violation measurement with E μ as low as 12 GeV can be considered. However, for large θ 13 , we show that the lower threshold and the backgrounds reconstructed at lower energies allow in fact for muon energies as low as 5 to 8 GeV at considerably shorter baselines, such as Fermilab to Homestake. This suggests that with the latest MIND simulation, low- and high-energy versions of the Neutrino Factory are just two different forms of the same experiment optimized for different regions of the parameter space.

  8. Advanced factory managing technology. Sentan kojo kanri gijuts

    Energy Technology Data Exchange (ETDEWEB)

    Matsushita, M [Daicel Chemical Industries, Ltd., Osaka (Japan)

    1994-04-05

    With respect to a managing technology of advanced factories in the Japanese chemical industry, this paper enumerates the following three examples to discuss the ways the future factory technologies should be: operation techniques and problems in a newest ethylene plant, operation supports and facility control in chemical factories, and CIM structuring in beer breweries. The paper describes the operation techniques in an ethylene plant that are broken down into the following: measures for safety and material diversification, environment preservation, means to minimize the required labor, adoption of multi-variables, non-interference control technology for ethylene-propylene columns, and operation techniques that have been introduced with such a new technique as an integrated instrumentation room equipped with a gas leakage detection system. Structuring of CIM in the cited beer brewery has followed the transition of IE-TQC-JIT-FMS-CIM. Although a beer brewery may give somewhat different image from an ordinary chemical plant, the beer brewing process resembles a chemical plant in that it operates reacting machines in batch multiple tanks, and uses instrumentations and controllers using sensors. The key point in the future development is an organic link between market fluctuation and production activities. 1 fig.

  9. Design Learning of Teaching Factory in Mechanical Engineering

    Science.gov (United States)

    Putra, R. C.; Kusumah, I. H.; Komaro, M.; Rahayu, Y.; Asfiyanur, E. P.

    2018-02-01

    The industrial world that is the target of the process and learning outcomes of vocational high school (SMK) has its own character and nuance. Therefore, vocational education institutions in the learning process should be able to make the appropriate learning approach and in accordance with the industrial world. One approach to learning that is based on production and learning in the world of work is by industry-based learning or known as Teaching Factory, where in this model apply learning that involves direct students in goods or service activities are expected to have the quality so it is worth selling and accepted by consumers. The method used is descriptive approach. The purpose of this research is to get the design of the teaching factory based on the competency requirements of the graduates of the spouse industry, especially in the engineering department. The results of this study is expected to be one of the choice of model factory teaching in the field of machinery engineering in accordance with the products and competencies of the graduates that the industry needs.

  10. Pulmonary functions in plastic factory workers: a preliminary study.

    Science.gov (United States)

    Khaliq, Farah; Singh, Pawan; Chandra, Prakash; Gupta, Keshav; Vaney, Neelam

    2011-01-01

    Exposure to long term air pollution in the work environment may result in decreased lung functions and various other health problems. A significant occupational hazard to lung functions is experienced by plastic factory workers. The present study is planned to assess the pulmonary functions of workers in the plastic factory where recycling of pastic material was done. These workers were constantly exposed to fumes of various chemicals throughout the day. Thirty one workers of plastic factory were assessed for their pulmonary functions. Parameters were compared with 31 age and sex matched controls not exposed to the same environment. The pulmonary function tests were done using Sibelmed Datospir 120 B portable spirometer. A significant decrease in most of the flow rates (MEF 25%, MEF 50%, MEF 75% and FEF 25-75%) and most of the lung volumes and capacities (FVC, FEV1, VC, TV, ERV, MVV) were observed in the workers. Smoking and duration of exposure were not affecting the lung functions as the non smokers also showed a similar decrement in pulmonary functions. Similarly the workers working for less than 5 years also had decrement in pulmonary functions indicating that their lungs are being affected even if they have worked for one year. Exposure to the organic dust in the work environment should be controlled by adequate engineering measures, complemented by effective personal respiratory protection.

  11. Study on Total Quality Management Activities in Taiwan Tourism Factories

    Directory of Open Access Journals (Sweden)

    Yi-Chan Chung

    2016-08-01

    Full Text Available As competition becomes increasingly fierce, how to integrate the concept of information technology involvement into total quality management activities and better serve the customers, thus increasing the effectiveness of their services, has become an important focus for many tourism factories in their selection of an appropriate operational strategy. With the tourism factories in Taiwan as the subjects, this study was therefore set out to investigate the impact of operational strategies, information technology involvement and motivation on the executive degree of total quality management (TQM activities, as well as the correlation between the executive degree of TQM activities and operational performance. This research was conducted from March to April 2016 using 56 effective questionnaires through a questionnaire survey method. According to the research findings, the higher the executive degree of TQM activities was, the more significant a positive impact it would have on operational performance; the execution of differentiation strategies would have a positive impact on the execution of TQM activities; the more a company was involved in information technology, the more significant a positive impact it would have on the execution of TQM activities; the higher the intrinsic motivation was, the more significant a positive impact it would have on the executive degrees of TQM activities. It is therefore advisable for tourism factories to implement TQM activities, adopt differentiation strategies, seek greater information technology involvement and become more strongly motivated toward TQM implementation in order to improve operational performance.

  12. [Effect of highway driving on the health of factory workers].

    Science.gov (United States)

    Uramoto, Hidetaka

    2008-06-01

    Commuting transportation is one of the important factors in the administration of safety management in industries. Most workers commute to work by car and are certain to make use of highways, mainly because of the special condition of factory locations. In this study, we investigated the effect of communicating by car on the health of factory workers. The proportion of males was significantly higher in the highway (HW) group than in the non-highway (NHW) group, and the former was younger than the latter. BMI, systolic blood pressure, diastolic blood pressure, and total cholesterol deteriorated significantly in the NHW group after 5-year periodic medical checkups. However, in the HW group, those factors did not change except for systolic blood pressure and significant improvements in triglyceride. The percentage of those who follow a good lifestyle regarding excise and nutrition, and have a solution for stress, was lower in the HW group than in the NHW group. Nevertheless, the percentage of those who did not feel stress was significantly higher in the HW group than in the NHW group, suggesting a stress-relieving effect of highway driving. Highway driving might have an unexpectedly good impact on the health of factory workers.

  13. Behavioral lifestyle and mental health status of Japanese factory workers.

    Science.gov (United States)

    Ezoe, S; Morimoto, K

    1994-01-01

    Lifestyle factors, sometimes associated with physical health and mortality, have also been known to be associated with mental health status. This study seeks to correlate behavioral lifestyles with major components of mental health among Japanese factory workers. We administered the 28-item version of the General Health Questionnaire (GHQ-28) and a questionnaire concerning eight personal health practices to 2,132 male and 668 female factory workers at a camera-manufacturing company in Japan. There were strong negative relationships of a higher total number of favorable lifestyles as indicated by the Health Practice Index (HPI) to psychological distress and its components: somatic symptoms, anxiety-insomnia, and social dysfunction. After controlling for the effects of confounding factors that included age, marital status, and somatic condition, multiple logistic regression analysis indicated that five of the eight health factors among male workers--mental stress, nutritional balance, eating breakfast regularly, physical exercise, and working hours--were significantly related to the grade of psychological distress or its three components. Among female workers, five health practices, i.e., mental stress, physical exercise, sleeping hours, working hours, and cigarette smoking, were significantly associated with the grade of psychological distress or its three components. Good health practices might be individually and as a whole associated with better mental health status in factory workers.

  14. Soybean oil biosynthesis: role of diacylglycerol acyltransferases.

    Science.gov (United States)

    Li, Runzhi; Hatanaka, Tomoko; Yu, Keshun; Wu, Yongmei; Fukushige, Hirotada; Hildebrand, David

    2013-03-01

    Diacylglycerol acyltransferase (DGAT) catalyzes the acyl-CoA-dependent acylation of sn-1,2-diacylglycerol to form seed oil triacylglycerol (TAG). To understand the features of genes encoding soybean (Glycine max) DGATs and possible roles in soybean seed oil synthesis and accumulation, two full-length cDNAs encoding type 1 diacylglycerol acyltransferases (GmDGAT1A and GmDGAT1B) were cloned from developing soybean seeds. These coding sequences share identities of 94 % and 95 % in protein and DNA sequences. The genomic architectures of GmDGAT1A and GmDGAT1B both contain 15 introns and 16 exons. Differences in the lengths of the first exon and most of the introns were found between GmDGAT1A and GmDGAT1B genomic sequences. Furthermore, detailed in silico analysis revealed a third predicted DGAT1, GmDGAT1C. GmDGAT1A and GmDGAT1B were found to have similar activity levels and substrate specificities. Oleoyl-CoA and sn-1,2-diacylglycerol were preferred substrates over vernoloyl-CoA and sn-1,2-divernoloylglycerol. Both transcripts are much more abundant in developing seeds than in other tissues including leaves, stem, roots, and flowers. Both soybean DGAT1A and DGAT1B are highly expressed at developing seed stages of maximal TAG accumulation with DGAT1B showing highest expression at somewhat later stages than DGAT1A. DGAT1A and DGAT1B show expression profiles consistent with important roles in soybean seed oil biosynthesis and accumulation.

  15. Jasmonate-induced biosynthesis of andrographolide in Andrographis paniculata.

    Science.gov (United States)

    Sharma, Shiv Narayan; Jha, Zenu; Sinha, Rakesh Kumar; Geda, Arvind Kumar

    2015-02-01

    Andrographolide is a prominent secondary metabolite found in Andrographis paniculata that exhibits enormous pharmacological effects. In spite of immense value, the normal biosynthesis of andrographolide results in low amount of the metabolite. To induce the biosynthesis of andrographolide, we attempted elicitor-induced activation of andrographolide biosynthesis in cell cultures of A. paniculata. This was carried out by using methyl jasmonate (MeJA) as an elicitor. Among the various concentrations of MeJA tested at different time periods, 5 µM MeJA yielded 5.25 times more andrographolide content after 24 h of treatment. The accumulation of andrographolide was correlated with the expression level of known regulatory genes (hmgs, hmgr, dxs, dxr, isph and ggps) of mevalonic acid (MVA) and 2-C-methyl-d-erythritol-4-phosphate (MEP) pathways. These results established the involvement of MeJA in andrographolide biosynthesis by inducing the transcription of its biosynthetic pathways genes. The coordination of isph, ggps and hmgs expression highly influenced the andrographolide biosynthesis. © 2014 Scandinavian Plant Physiology Society.

  16. Regulation of anthocyanin biosynthesis in peach fruits.

    Science.gov (United States)

    Rahim, Md Abdur; Busatto, Nicola; Trainotti, Livio

    2014-11-01

    MYB10.1 and MYB10.3, with bHLH3, are the likely regulators of anthocyanin biosynthesis in peach fruit. MYB10.1/2/3 forms a cluster on the same genomic fragment where the Anther color ( Ag ) trait is located. Anthocyanins are bioactive compounds responsible for the pigmentation of many plant parts such as leaves, flowers, fruits and roots, and have potential benefits to human health. In peach [Prunus persica (L.) Batsch], peel color is a key determinant for fruit quality and is regulated by flavonoids including anthocyanins. The R2R3 MYB transcription factors (TFs) control the expression of anthocyanin biosynthetic genes with the help of co-activators belonging to the basic-helix-loop-helix (bHLH) and WD40 repeat families. In the peach genome six MYB10-like and three bHLH-like TFs were identified as candidates to be the regulators of the anthocyanin accumulation, which, in yellow flesh fruits, is highest in the peel, abundant in the part of the mesocarp surrounding the stone and lowest in the mesocarp. The expression of MYB10.1 and MYB10.3 correlates with anthocyanin levels of different peach parts. They also have positive correlation with the expression of key structural genes of the anthocyanin pathway, such as CHS, F3H, and UFGT. Functions of peach MYB10s were tested in tobacco and shown to activate key genes in the anthocyanin pathway when bHLHs were co-expressed as partners. Overexpression of MYB10.1/bHLH3 and MYB10.3/bHLH3 activated anthocyanin production by up-regulating NtCHS, NtDFR and NtUFGT while other combinations were not, or much less, effective. As three MYB10 genes are localized in a genomic region where the Ag trait, responsible for anther pigmentation, is localized, it is proposed they are key determinant to introduce new peach cultivars with higher antioxidant level and pigmented fruit.

  17. Inhibitors of amino acids biosynthesis as antifungal agents.

    Science.gov (United States)

    Jastrzębowska, Kamila; Gabriel, Iwona

    2015-02-01

    Fungal microorganisms, including the human pathogenic yeast and filamentous fungi, are able to synthesize all proteinogenic amino acids, including nine that are essential for humans. A number of enzymes catalyzing particular steps of human-essential amino acid biosynthesis are fungi specific. Numerous studies have shown that auxotrophic mutants of human pathogenic fungi impaired in biosynthesis of particular amino acids exhibit growth defect or at least reduced virulence under in vivo conditions. Several chemical compounds inhibiting activity of one of these enzymes exhibit good antifungal in vitro activity in minimal growth media, which is not always confirmed under in vivo conditions. This article provides a comprehensive overview of the present knowledge on pathways of amino acids biosynthesis in fungi, with a special emphasis put on enzymes catalyzing particular steps of these pathways as potential targets for antifungal chemotherapy.

  18. NAD+ biosynthesis, aging, and disease [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Sean Johnson

    2018-02-01

    Full Text Available Nicotinamide adenine dinucleotide (NAD+ biosynthesis and its regulation have recently been attracting markedly increasing interest. Aging is marked by a systemic decrease in NAD+ across multiple tissues. The dysfunction of NAD+ biosynthesis plays a critical role in the pathophysiologies of multiple diseases, including age-associated metabolic disorders, neurodegenerative diseases, and mental disorders. As downstream effectors, NAD+-dependent enzymes, such as sirtuins, are involved in the progression of such disorders. These recent studies implicate NAD+ biosynthesis as a potential target for preventing and treating age-associated diseases. Indeed, new studies have demonstrated the therapeutic potential of supplementing NAD+ intermediates, such as nicotinamide mononucleotide and nicotinamide riboside, providing a proof of concept for the development of an effective anti-aging intervention.

  19. Zincophorin – biosynthesis in Streptomyces griseus and antibiotic properties

    Directory of Open Access Journals (Sweden)

    Walther, Elisabeth

    2016-11-01

    Full Text Available Zincophorin is a polyketide antibiotic that possesses potent activity against Gram-positive bacteria, including human pathogens. While a number of total syntheses of this highly functionalized natural product were reported since its initial discovery, the genetic basis for the biosynthesis of zincophorin has remained unclear. In this study, the co-linearity inherent to polyketide pathways was used to identify the zincophorin biosynthesis gene cluster in the genome of the natural producer HKI 0741. Interestingly, the same locus is fully conserved in the streptomycin-producing actinomycete IFO 13350, suggesting that the latter bacterium is also capable of zincophorin biosynthesis. Biological profiling of zincophorin revealed a dose-dependent inhibition of the Gram-positive bacterium . The antibacterial effect, however, is accompanied by cytotoxicity. Antibiotic and cytotoxic activities were completely abolished upon esterification of the carboxylic acid group in zincophorin.

  20. Purine biosynthesis de novo by lymphocytes in gout

    International Nuclear Information System (INIS)

    Kamoun, P.; Chanard, J.; Brami, M.; Funck-Brentano, J.L.

    1978-01-01

    A method of measurement in vitro of purine biosynthesis de novo in human circulating blood lymphocytes is proposed. The rate of early reactions of purine biosynthesis de novo was determined by the incorporation of [ 14 C]formate into N-formyl glycinamide ribonucleotide when the subsequent reactions of the metabolic pathway were completely inhibited by the antibiotic azaserine. Synthesis of 14 C-labelled N-formyl glycinamide ribonucleotide by lymphocytes was measured in healthy control subjects and patients with primary gout or hyperuricaemia secondary to renal failure, with or without allopurinol therapy. The average synthesis was higher in gouty patients without therapy than in control subjects, but the values contained overlap the normal range. In secondary hyperuricaemia the synthesis was at same value as in control subjects. These results are in agreement with the inconstant acceleration of purine biosynthesis de novo in gouty patients as seen by others with measurement of [ 14 C]glycine incorporation into urinary uric acid. (author)

  1. Methoxypyrazines biosynthesis and metabolism in grape: A review.

    Science.gov (United States)

    Lei, Yujuan; Xie, Sha; Guan, Xueqiang; Song, Changzheng; Zhang, Zhenwen; Meng, Jiangfei

    2018-04-15

    This review summarizes research on the discovery, biosynthesis, accumulation, transport, and metabolism of 3-alkyl-2-methoxypyrazines (MPs) in grape. The MPs are a family of potent volatile compounds distributed throughout biological kingdoms. These compounds impart herbaceous/green/vegetal sensory attributes to certain varieties of wine. Generally, high levels of MPs in wine are derived mainly from the corresponding grapes. Although two pathways for MPs biosynthesis have been proposed, only the final step and the enzymes that catalyze it has been confirmed in grape, and the metabolic intermediates and key enzymes involved in other steps are still unknown. The limited understanding of MPs metabolism has restricted research on these compounds, and some empirical results cannot be explained by the current knowledge of MPs metabolism. This review provides insights into research on MPs biosynthesis and metabolism, and proposes directions for further research on this important class of flavour/odour compounds. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Genes encoding enzymes of the lignin biosynthesis pathway in Eucalyptus

    Directory of Open Access Journals (Sweden)

    Ricardo Harakava

    2005-01-01

    Full Text Available Eucalyptus ESTs libraries were screened for genes involved in lignin biosynthesis. This search was performed under the perspective of recent revisions on the monolignols biosynthetic pathway. Eucalyptus orthologues of all genes of the phenylpropanoid pathway leading to lignin biosynthesis reported in other plant species were identified. A library made with mRNAs extracted from wood was enriched for genes involved in lignin biosynthesis and allowed to infer the isoforms of each gene family that play a major role in wood lignin formation. Analysis of the wood library suggests that, besides the enzymes of the phenylpropanoids pathway, chitinases, laccases, and dirigent proteins are also important for lignification. Colocalization of several enzymes on the endoplasmic reticulum membrane, as predicted by amino acid sequence analysis, supports the existence of metabolic channeling in the phenylpropanoid pathway. This study establishes a framework for future investigations on gene expression level, protein expression and enzymatic assays, sequence polymorphisms, and genetic engineering.

  3. The vibration measurements at the photon factory storage ring building

    International Nuclear Information System (INIS)

    Haga, K.; Nakayama, M.; Masuda, K.; Ishizaki, H.; Kura, M.; Meng, L.; Oku, Y.

    1999-01-01

    The Photon Factory is a 2.5 GeV electron storage ring and has been operating since 1982 as a dedicated SR source. At the Photon Factory, we have been pursuing the various sources of the beam instabilities which deteriorated the SR beam quality in the wide frequency range. Some of the sources were the vibrations of magnets and floor of the ring tunnel, temperature change of the cooling water and the elongation of the storage ring building roof due to sunshine that induced the diurnal motion of the SR beam axis. This article presents the results of the vibration measurements that have been performed at the Photon Factory storage ring building. (1) The vibrations of the ring tunnel floor and the experimental hall floor, comparing with the vibration of the ground surrounding the storage ring building, are same order in the 1 ∼ 5 Hz range, and 1/3 ∼ 1/5 in the 5 ∼ 100 Hz range, in the vertical and the horizontal direction. (2) The effects of the vibration arising from the operating eight air-conditioners can be seen in the Fourier spectrum of the vibration of the ring tunnel floor, experimental floor, Q-magnets and BPM vacuum duct. (3) The vibrations of the Q-magnet and girder at frequencies near their fundamental resonant frequencies have been amplified 100 limes in the lateral direction comparing to the floor vibration. (4) Correlation between the vibration of the BPM vacuum duct and the vibration of the electron beam motion is unknown for the lack of the precise data. (authors)

  4. Quantum mechanics paradoxes at the Φ-factory

    International Nuclear Information System (INIS)

    Ghirardi, G.C.; Grassi, R.; Weber, T.

    1991-04-01

    We discuss the possibility of performing experiments allowing one to test quantum mechanics versus any local realistic model within the context of the physics at the Φ-factory. After having sketched the main features of the physical process under consideration and having focused the locality requirements for it, we derive Bell's inequality for the two-meson system. Comparison with quantum predictions shows that the inequality is not violated for any choice of the parameters characterizing the measurement process. Contrary to the case of spin variables, there is then no way to exclude, by experiments at the Φ-factory, the possibility of a local realistic description of the process. A recent suggestion about a test of quantum predictions versus the assumption of a spontaneous factorization mechanism, as well as the claimed validity of an inequality which is different from Bell's one, are also discussed. The general conclusion is that the Φ-factory facility does not seem to open new ways of testing quantum mechanics versus alternative general schemes of the type which are usually regarded as worth considering the debate about locality and quantum mechanics. The concluding Section is devoted to making clear our position with respect to the problems discussed in this paper. It is pointed out that, in our opinion, the existing experimental evidence makes already clear that one has to accept the ''mysterious'' features of microscopic systems. The really crucial problem is that of investigating whether one can restore a coherent worldview which generally conforms with our experience at the macroscopic level, by keeping all highly successful predictions of quantum theory at the microscopic one. (author). 22 refs

  5. [Risk assessment and countermeasure of BTEX in pesticide factory].

    Science.gov (United States)

    Pang, Bo; Wang, Tie-Yu; Du, Li-Yu; Tan, Bing; Zhu, Zhao-Yun; Lu, Yong-Long

    2013-07-01

    BTEX are important environmental pollutants, harmful to human through respiratory inhalation, digestive tract and skin contact, and also have teratogenic, mutagenic and carcinogenic effects. BTEX were detected in multi-media to identify their distributions and assess their human health risk in a pesticide factory in Hebei province. Purge and trap GC-MS, adsorption/thermal desorption GC chromatography and the health risk assessment model were applied, and corresponding management measures were proposed. The results showed that BTEX existed in soil, dust, air, groundwater and wastewater. The concentration of BTEX in dust of the production area was 7.33 mg x kg(-1), in particular the concentration of toluene was 5.64 mg x kg(-1), exceeding the Canadian industrial land standard. Building three scenarios for working more than 10 years, 20 years and 30 years, the total non-carcinogens index was 4.19 x10(-3), 8.25 x 10(-3) and 1.22 x 10(-2), respectively, all lower than 1; the carcinogens index of benzene was 1.70 x 10(-7), 3.34 x 10(-7) and 4.92 x 10(-7), respectively, all lower than 10(-6). It indicated that there was no significant non-carcinogens and carcinogens hazard to workers inside the factory, but they might be exposed to more health risks if their work experience increase. Finally, recommendations for improving the environmental quality and personnel security in the factory were proposed based on the research results.

  6. Effects of chromium exposure from a cement factory

    International Nuclear Information System (INIS)

    Isikli, B.; Demir, T.A.; Uerer, S.M.; Berber A.; Akar, T.; Kalyoncu, C.

    2003-01-01

    The aim of the study was to determine the chromium concentrations of soil and plant specimens taken from a rural area exposed to cement factory emissions and also to determine the blood concentrations and sensitivity conditions observed in humans residing in this rural area. The study was carried out in Cukurhisar, a town in Eskisehir-Turkey, between May 2000 an March 2001. Besides the 108 soil (36 for control) and plant specimens, which were taken from eight different directions from the cement factory, blood samples of the individuals residing in this area were taken from 258 subject (258 for control) following a physical examination, and patch tests were als applied. The chromium concentrations of the soil and plant specimens take from different places in different directions of the factory were higher than in the control areas. The physical examination of subjects did not reveal results different from those of the control group except for the diagnosis of contact dermatitis. The analyses of venous blood samples showed that chromium concentrations were found to be within the reference values given for bot groups, but higher in the subjects (P<0.001). According to the results o patch tests, sensitivity to chromium was found to be more frequent for the subject group than the control group (P<0.05). According to these results clinical tools revealed no toxic effects for the subjects, except contact dermatitis. However, sensitivity to patch tests showed that this subject group has been affected compared to the control group and that this effect increased with age

  7. RI beam factory and its expected pioneering work

    International Nuclear Information System (INIS)

    Yano, Yasushige

    1996-01-01

    The RARF (RIKEN Accelerator Research Facility) houses an intermediate-energy heavy-ion accelerator complex consisting of a K540-MeV ring cyclotron (RRC) and a couple of different types of the injectors: a variable-frequency heavy-ion linac and a K70-MeV AVF cyclotron. One of remarkable features of this facility is capability of supplying light-atomic-mass RI (radioactive isotope) beams with the world-highest level of intensities by the projectile-fragment separator, RIPS. In these several years nuclear physicists have opened up a quite new and fascinating heavy-ion science exploiting such RI beams. In order to further promote this new science, the RARF proposes 'RIKEN RI Beam Factory' as a next facility-expanding project. The factory takes the aim at providing RI beams covering over the whole atomic-mass range with the world-highest intensities in a wide energy range up to several hundreds MeV/nucleon. To realize the 'Factory' a K2500-MeV superconducting ring cyclotron will be built which boosts output energies of the RRC beams up to 400 MeV/nucleon for light ions and up to 100 MeV/nucleon for very heavy ions, preserving their beam intensities (typically 1 pμA). RI beams will be generated by the projectile fragmentation. A new type of experimental installation called 'MUSES' (Multi-USe Experimental Storage rings) will also be constructed. It consists of an accumulator-cooler ring, booster synchrotron ring and double storage rings. With MUSES, various types of unique colliding experiments will become possible: ion-ion merging or head-on collisions; collisions of either electrons or X-rays with ion (stable isotope or RI) beams; internal target experiments; and atomic and molecular physics with cooler electron beams. (author)

  8. Sterile neutrinos beyond LSND at the neutrino factory

    International Nuclear Information System (INIS)

    Meloni, Davide; Tang Jian; Winter, Walter

    2010-01-01

    We discuss the effects of one additional sterile neutrino at the Neutrino Factory. Compared to earlier analyses, which have been motivated by Liquid Scintillator Neutrino Detector (LSND) results, we do not impose any constraint on the additional mass squared splitting. This means that the additional mass eigenstate could, with small mixings, be located among the known ones, as it is suggested by the recent analysis of cosmological data. We use a self-consistent framework at the Neutrino Factory without any constraints on the new parameters. We demonstrate for a combined short and long baseline setup that near detectors can provide the expected sensitivity at the LSND-motivated Δm 41 2 -range, while some sensitivity can also be obtained in the region of the atmospheric mass splitting from the long baselines. We point out that limits on such very light sterile neutrinos may also be obtained from a reanalysis of atmospheric and solar neutrino oscillation data, as well as from supernova neutrino observations. In the second part of the analysis, we compare our sensitivity with the existing literature using additional assumptions, such as |Δm 41 2 |>>|Δm 31 2 |, leading to averaging of the fast oscillations in the far detectors. We demonstrate that while the Neutrino Factory has excellent sensitivity compared to existing studies using similar assumptions, one has to be very careful interpreting these results for a combined short and long baseline setup where oscillations could occur in the near detectors. We also test the impact of additional ν τ detectors at the short and long baselines, and we do not find a substantial improvement of the sensitivities.

  9. Estructura factorial del Cuestionario de Creencias Adictivas en Fumadores (CCAF

    Directory of Open Access Journals (Sweden)

    Alejandro Pérez

    2016-06-01

    Full Text Available Introducción: las creencias adictivas constituyen un riesgo para el uso de sustancias; contribuyen a mantener el consumo y proporcionan un trasfondo para la recaída. En la actualidad existen cuestionarios que miden creencias relacionadas con el consumo de sustancias de manera global, pero ninguno está enfocado en evaluar creencias adictivas en fumadores; hacerlo apoyaría en el manejo clínico de las personas que buscan dejar de fumar. Objetivo: evaluar la estructura factorial de un cuestionario que mide creencias adictivas en fumadores. Método: mediante un muestreo intencional se obtuvo una muestra de 300 jóvenes fumadores mayores de 18 años. Todos los participantes respondieron un cuestionario de autorreporte compuesto por 60 ítems que exploran creencias relacionadas con el consumo de tabaco. Se realizó un análisis factorial confirmatorio (AFC para determinar el modelo con un ajuste adecuado. Resultados: luego de evaluar dos modelos con AFC, se seleccionó uno de tres factores con una carga cruzada, cuyas medidas de bondad de ajuste fueron X2 S-B (22 = 38.37, p = .01, X2 S-B / gl = 1.74. CFIS = .978 RMSEAS = .050 (IC 90% .021–.076, que indican un ajuste adecuado de los datos. Discusión y conclusiones: la estructura factorial del CCAF está asociada con las creencias adictivas descritas por Beck. El CCAF es una herramienta breve que podría coadyuvar en el tratamiento de personas que buscan dejar de fumar.

  10. Evaluation of ring impedance of the Photon Factory storage ring

    International Nuclear Information System (INIS)

    Kiuchi, T.; Izawa, M.; Tokumoto, S.; Hori, Y.; Sakanaka, S.; Kobayashi, M.; Kobayakawa, H.

    1992-05-01

    The loss parameters of the ducts in the Photon Factory (PF) storage ring were evaluated using the wire method and the code TBCI. Both the measurement and the calculation were done for a different bunch length (σ) ranging from 23 to 80 ps. The PF ring impedance was estimated to be |Z/n|=3.2 Ω using the broadband impedance model. The major contribution to the impedance comes from the bellows and the gate valve sections. Improvements of these components will lower the ring impedance by half. (author)

  11. The kaon factory - towards the physics of strongly interacting systems

    International Nuclear Information System (INIS)

    Vogt, Erich

    1988-01-01

    With the advent of the standard model for quarks and leptons and unified forces there are profound new questions for the physics of strongly interacting systems: the nature of the nucleon, the physics of quark confinement, fundamental symmetries governing hadron decay and the effect of quarks and gluons on nuclear behaviour. Of the new large facilities now planned to respond to these questions the kaon factory is central. It uses very intense (∼100 μA) primary proton beams (∼30 GeV) to generate intense secondary beams of various hadrons and leptons. (author)

  12. Linac upgrade plan for the KEK B-Factory

    International Nuclear Information System (INIS)

    Enomoto, Atsushi; Anami, Shozo; Kamitani, Takuya; Hanaki, Hirofumi; Shidara, Tetsuo; Sato, Isamu

    1993-01-01

    In the KEK B-Factory plan, e+/e- collider rings with 3.5- GeV positions and 8-GeV electrons are being considered, and full-energy injection from the existing linac is required. The acceleration energy of the linac must be upgraded from 2.5 to 8 GeV. The most effective way has been searched from several points of view, such as the beam quality, ease of beam handling, and construction. This article describes the basic plan of the energy upgrade and recent progress regarding this project

  13. B-meson factories: Physics, machines and detectors

    International Nuclear Information System (INIS)

    Kolanoski, H.

    1990-10-01

    This report gives a short survey of the present status of B-meson factory plans and discussions at different laboratories. The physics motivation for an e + e - machine running with the highest possible luminosity in the Γ(4S) energy region is outlined emphasizing the possibility to observe CP violation in the B-meson system. The technical concepts for such machines together with the basic luminosity limitations are discussed. Finally, the requirements on a detector which is able to cover the rich physics program are presented. (orig.)

  14. Micro Tools with Pneumatic Actuators for Desktop Factories

    Directory of Open Access Journals (Sweden)

    Björn HOXHOLD

    2009-10-01

    Full Text Available This paper presents the design, the simulation and the fabrication process of two novel pneumatically driven auxiliary micro tools that can be used to improve and to speed up assembling processes in desktop factories. The described micro systems are designed to function as centrifugal feeders for small glass balls or active clamping devices with small external dimensions. They are able to deliver more than six balls per second on demand to a gripper and align and clamp single chips in a fixed position.

  15. The computer control system for the CESR B factory

    International Nuclear Information System (INIS)

    Strohman, C.R.; Rice, D.H.; Peck, S.B.

    1992-01-01

    B factories present unique requirements for controls and instrumentation systems. High reliability is critical to achieving the integrated luminosity goals. The CESR-B upgrade at Cornell University will have a control system based on the architecture of the successful CESR control system, which uses a centralized database/massage routing system in a multiported memory, and VAX stations for all high-level control functions. The implementation of this architecture will address the deficiencies in the current implementation while providing the required performance and reliability. (author)

  16. Charmonium physics at a tau-charm factory

    International Nuclear Information System (INIS)

    Barnes, T.; Univ. of Tennessee, Knoxville, TN

    1993-01-01

    Since its discovery in 1974 the charmonium system has served hadron physics as an important arena for the investigation of many aspects of QCD and hadron spectroscopy. In this summary the author briefly reviews some of these and discusses several of the important outstanding issues in hadron spectroscopy and their relation to the spectrum and couplings of resonances in the charmonium system. The topics discussed are charmonium spectroscopy, electromagnetic couplings (γ, γγ and e + e - ), strong decays and unusual states (charm molecules and charmonium hybrids), and in each case the author notes areas in which experiments at a tau-charm factory could make valuable contributions

  17. Characterization of undulator radiation at the Photon Factory

    International Nuclear Information System (INIS)

    Maezawa, Hideki; Kitamura, Hideo; Sasaki, Taizo; Suzuki, Yoshio

    1986-01-01

    Spectra of undulator radiation of the Photon Factory undulator, model PMU-2, were measured in a scale of absolute brightness in the soft X-ray region for various values of the K-parameter from 0.72 to 1.66. A significant reduction of the peak brightness was observed, whereas we also observed a relatively sharp edge at the high energy side of the first harmonic. The results show that the peak brightness and the band width are highly dependent on the beam parameters and the geometry of spectral observation. (orig.)

  18. Characterization of undulator radiation at the photon factory

    Science.gov (United States)

    Maezawa, Hideki; Suzuki, Yoshio; Kitamura, Hideo; Sasaki, Taizo

    1986-05-01

    Spectra of undulator radiation of the Photon Factory undulator, model PMU-2, were measured in a scale of absolute brightness in the soft X-ray region for various values of the K-parameter from 0.72 to 1.66. A significant reduction of the peak brightness was observed, whereas we also observed a relatively sharp edge at the high energy side of the first harmonic. The results show that the peak brightness and the band width are highly dependent on the beam parameters and the geometry of spectral observation.

  19. The τ-charm factory: physics, machine and detector

    International Nuclear Information System (INIS)

    Kirkby, J.

    1990-01-01

    We describe a new experiment that will carry out precise studies of the third generation leptons, τ and ν τ ; the second generation quark family, through the decays of D ± , D 0 and D s ± ; and the spectrum of gluonic and other new light particles in the decays of J/ψ and ψ'. The experiment - the τ-charm Factory (τcF) - involves a high-resolution detector integrated with an e + e - collider operating in the energy range 3.0≤E cm ≤4.25 GeV with a maximum luminosity 10 33 cm -2 s -1 . (author)

  20. A superconducting focusing solenoid for the neutrino factory linear accelerator

    International Nuclear Information System (INIS)

    Green, Michael A.; Lebedev, V.; Strauss, B.P.

    2001-01-01

    The proposed linear Accelerator that accelerates muons from 190 MeV to 2.45 GeV will use superconducting solenoids for focusing the muon beam. The accelerator will use superconducting RF cavities. These cavities are very sensitive to stay magnetic field from the focusing magnets. Superconducting solenoids can produce large stray fields. This report describes the 201.25 MHz acceleration system for the neutrino factory. This report also describes a focusing solenoid that delivers almost no stray field to a neighboring superconducting RF cavity

  1. Interaction region considerations for a B-factory

    International Nuclear Information System (INIS)

    DeStaebler, H.

    1990-07-01

    The goal of the project is to observe CP violation in the bar BB system. This machine is supposed to be a factory for high energy physics, not an R ampersand D project for accelerator physics. There are a number of interrelated design issues arising from the different desires of the detector and the machine, some of which are listed in this paper. A number of background and beampipe issues are mentioned. The emphasis is on calculations. Any satisfactory design will combine measurements on existing machines with calculations pertaining to the measurement conditions as well as to the proposed machine. 57 refs

  2. A database for operation logging of the KEK photon factory

    International Nuclear Information System (INIS)

    Pak, C.O.

    1990-01-01

    A prototype database for operation logging of the KEK Photon Factory storage ring has been constructed and tested. This paper describes the basic design of the operation logging system and its performance. Front-end control computers gather various data concerning the operation of the storage ring, and transfer them to a large general-purpose computer through a token-ring network. We have adopted a relational database system so as to save large amounts of data under daily operation. An interactive software tool was developed to retrieve data and to make graphic representations easily. (orig.)

  3. Recent advances in combinatorial biosynthesis for drug discovery

    Directory of Open Access Journals (Sweden)

    Sun H

    2015-02-01

    Full Text Available Huihua Sun,1,* Zihe Liu,1,* Huimin Zhao,1,2 Ee Lui Ang1 1Metabolic Engineering Research Laboratory, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research, Singapore; 2Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA *These authors contributed equally to this work Abstract: Because of extraordinary structural diversity and broad biological activities, natural products have played a significant role in drug discovery. These therapeutically important secondary metabolites are assembled and modified by dedicated biosynthetic pathways in their host living organisms. Traditionally, chemists have attempted to synthesize natural product analogs that are important sources of new drugs. However, the extraordinary structural complexity of natural products sometimes makes it challenging for traditional chemical synthesis, which usually involves multiple steps, harsh conditions, toxic organic solvents, and byproduct wastes. In contrast, combinatorial biosynthesis exploits substrate promiscuity and employs engineered enzymes and pathways to produce novel “unnatural” natural products, substantially expanding the structural diversity of natural products with potential pharmaceutical value. Thus, combinatorial biosynthesis provides an environmentally friendly way to produce natural product analogs. Efficient expression of the combinatorial biosynthetic pathway in genetically tractable heterologous hosts can increase the titer of the compound, eventually resulting in less expensive drugs. In this review, we will discuss three major strategies for combinatorial biosynthesis: 1 precursor-directed biosynthesis; 2 enzyme-level modification, which includes swapping of the entire domains, modules and subunits, site-specific mutagenesis, and directed evolution; 3 pathway-level recombination. Recent examples of combinatorial biosynthesis employing these

  4. Investigation of cadmium pollution in the spruce saplings near the metal production factory.

    Science.gov (United States)

    Hashemi, Seyed Armin; Farajpour, Ghasem

    2016-02-01

    Toxic metals such as lead and cadmium are among the pollutants that are created by the metal production factories and disseminated in the nature. In order to study the quantity of cadmium pollution in the environment of the metal production factories, 50 saplings of the spruce species at the peripheries of the metal production factories were examined and the samples of the leaves, roots, and stems of saplings planted around the factory and the soil of the environment of the factory were studied to investigate pollution with cadmium. They were compared to the soil and saplings of the spruce trees planted outside the factory as observer region. The results showed that the quantity of pollution in the leaves, stems, and roots of the trees planted inside the factory environment were estimated at 1.1, 1.5, and 2.5 mg/kg, respectively, and this indicated a significant difference with the observer region (p metal production factory was estimated at 6.8 mg/kg in the depth of 0-10 cm beneath the level of the soil. The length of roots in the saplings planted around the factory of metal production stood at 11 and 14.5 cm in the observer region which had a significant difference with the observer region (p production processes in the factory. © The Author(s) 2013.

  5. Final Report on Regulation of Guaiacyl and Syringyl Monolignol Biosynthesis

    Energy Technology Data Exchange (ETDEWEB)

    Vincent L. Chiang

    2006-03-09

    The focus of this research is to understand syringyl monolignol biosynthesis that leads to the formation of syringyl lignin, a type of lignin that can be easily removed during biomass conversion. We have achieved the three originally proposed goals for this project. (1) SAD and CAD genes (enzyme catalytic and kinetic properties) and their functional relevance to CAld5H/AldOMT pathway, (2) spatiotemporal expression patterns of Cald5H, AldOMT, SAD and CAD genes, and (3) functions of CAld5H, AldOMT, and SAD genes in vivo using transgenic aspen. Furthermore, we also found that microRNA might be involved in the upstream regulatory network of lignin biosynthesis and wood formation. The achievements are as below. (1) Based on biochemical and molecular studies, we discovered a novel syringyl-specific alcohol dehydrogenase (SAD) involved in monolignol biosynthesis in angiosperm trees. Through CAld5H/OMT/SAD mediation, syringyl monolignol biosynthesis branches out from guaiacyl pathway at coniferaldehyde; (2) The function of CAld5H gene in this syringyl monolignol biosynthesis pathway also was confirmed in vivo in transgenic Populus; (3) The proposed major monolignol biosynthesis pathways were further supported by the involving biochemical functions of CCR based on a detailed kinetic study; (4) Gene promoter activity analysis also supported the cell-type specific expression of SAD and CAD genes in xylem tissue, consistent with the cell-specific locations of SAD and CAD proteins and with the proposed pathways; (5) We have developed a novel small interfering RNA (siRNA)-mediated stable gene-silencing system in transgenic plants; (6) Using the siRNA and P. trichocarpa transformation/regeneration systems we are currently producing transgenic P. trichocarpa to investigate the interactive functions of CAD and SAD in regulating guaiacyl and syringyl lignin biosynthesis; (7) We have cloned for the first time from a tree species, P. trichocarpa, small regulatory RNAs termed micro

  6. Pseudopterosin Biosynthesis: Aromatization of the Diterpene Cyclase Product, Elisabethatriene

    Directory of Open Access Journals (Sweden)

    Amber C. Kohl

    2003-11-01

    Full Text Available Abstract: Putative precursors in pseudopterosin biosynthesis, the hydrocarbons isoelisabethatriene (10 and erogorgiaene (11, have been identified from an extract of Pseudopterogorgia elisabethae collected in the Florida Keys. Biosynthetic experiments designed to test the utilization of these compounds in pseudopterosin production revealed that erogorgiaene is transformed to pseudopterosins A-D. Together with our previous data, it is now apparent that early steps in pseudopterosin biosynthesis involve the cyclization of geranylgeranyl diphosphate to elisabethatriene followed by the dehydrogenation and aromatization to erogorgiaene.

  7. In vitro biosynthesis of unnatural enterocin and wailupemycin polyketides.

    Science.gov (United States)

    Kalaitzis, John A; Cheng, Qian; Thomas, Paul M; Kelleher, Neil L; Moore, Bradley S

    2009-03-27

    Nature has evolved finely tuned strategies to synthesize rare and complex natural products such as the enterocin family of polyketides from the marine bacterium Streptomyces maritimus. Herein we report the directed ex vivo multienzyme syntheses of 24 unnatural 5-deoxyenterocin and wailupemycin F and G analogues, 18 of which are new. We have generated molecular diversity by priming the enterocin biosynthesis enzymes with unnatural substrates and have illustrated further the uniqueness of this type II polyketide synthase by way of exploiting its unusual starter unit biosynthesis pathways.

  8. Sequential enzymatic epoxidation involved in polyether lasalocid biosynthesis.

    Science.gov (United States)

    Minami, Atsushi; Shimaya, Mayu; Suzuki, Gaku; Migita, Akira; Shinde, Sandip S; Sato, Kyohei; Watanabe, Kenji; Tamura, Tomohiro; Oguri, Hiroki; Oikawa, Hideaki

    2012-05-02

    Enantioselective epoxidation followed by regioselective epoxide opening reaction are the key processes in construction of the polyether skeleton. Recent genetic analysis of ionophore polyether biosynthetic gene clusters suggested that flavin-containing monooxygenases (FMOs) could be involved in the oxidation steps. In vivo and in vitro analyses of Lsd18, an FMO involved in the biosynthesis of polyether lasalocid, using simple olefin or truncated diene of a putative substrate as substrate mimics demonstrated that enantioselective epoxidation affords natural type mono- or bis-epoxide in a stepwise manner. These findings allow us to figure out enzymatic polyether construction in lasalocid biosynthesis. © 2012 American Chemical Society

  9. Topical problems in the biosynthesis of red blood pigment

    International Nuclear Information System (INIS)

    Franck, B.

    1982-01-01

    Uroporphyrinogen III plays a key role in the biosynthesis of heme, the red pigment of blood. In vivo studies with specifically 14 C- and 3 H-labeled precursors have revealed that the formation of uroporphyrinogen III in the organism follows several primary and subsidiary pathways. Model experiments on the pattern of biosynthesis have led to simple and effective methods of synthesizing uroporphyrin analogs and have shwon that their production is strongly favored thermodynamically, The biologically important porphyrins thus available permit a mechanistic explanantion of the light-induced dermatoses in porphyria diseases and suggest promising medical applications in diagnosis and therapy. (orig.)

  10. Structure, Biosynthesis, and Occurrence of Bacterial Pyrrolizidine Alkaloids.

    Science.gov (United States)

    Schimming, Olivia; Challinor, Victoria L; Tobias, Nicholas J; Adihou, Hélène; Grün, Peter; Pöschel, Laura; Richter, Christian; Schwalbe, Harald; Bode, Helge B

    2015-10-19

    Pyrrolizidine alkaloids (PAs) are widespread plant natural products with potent toxicity and bioactivity. Herein, the identification of bacterial PAs from entomopathogenic bacteria using differential analysis by 2D NMR spectroscopy (DANS) and mass spectrometry is described. Their biosynthesis was elucidated to involve a non-ribosomal peptide synthetase. The occurrence of these biosynthesis gene clusters in Gram-negative and Gram-positive bacteria indicates an important biological function in bacteria. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Solving multi-product inventory ship routing with a heterogeneous fleet model using a hybrid cross entropy-genetic algorithm: a case study in Indonesia

    Directory of Open Access Journals (Sweden)

    Budi Santosa

    2016-01-01

    Full Text Available This paper presents a model and an algorithm for an inventory ship routing problem (ISRP. It consists of two main parts: a model development of the ship routing problem in a multi-product inventory with a heterogeneous fleet and an algorithm development to solve the problem. The problem is referred to as ISRP. ISRP considers several parameters including the deadweight tonnage (DWT, product compatibility, port setup, and compartment washing costs. Considering these parameters, the objective function is to minimize the total cost, which consists of traveling, port setup, ship charter, and compartment washing costs. From the resulting model, there are two major steps used to solve the problem. The first is to select the ships in order to satisfy the constraint that restricts the mooring rule. The second is to find the best route, product allocation, and shipped quantity. ISRP is an Non Polynomial-hard problem. Finding the solution of such problem needs a high computation time. A new hybrid metaheuristics, namely the cross entropy-genetic algorithm (CEGA, was proposed to solve ISRP. The results were then compared with those resulted from a hybrid Tabu Search to measure the hybrid CEGA performance. The results showed that CEGA provided better solutions than those produced by the hybrid Tabu Search.

  12. Investigation of Burnout in Employees Working in a Factory

    Directory of Open Access Journals (Sweden)

    Yasemin Aslan

    2010-10-01

    Full Text Available AIM: This study was performed to determine the burnout levels of employees working in a factory and the factors affecting it. METHOD: This is a cross–sectional study. The study population and sample consisted of 247 employees working in the workshops of a factory located in the a big city center. Data collection was performed using a Personal Information Form and the Maslach Burnout Inventory (MBI. RESULTS: The mean burnout scores increased (p<0.05 with decreasing age and work years of the employees. The mean Emotional Exhaustion score of the employees who were university graduates were higher than those who were primary school or high school graduates (p<0.05. Mean Emotional Exhaustion and Depersonalization scores of employees with no children were higher than those with children (p<0.05. Mean Emotional Exhaustion and Depersonalization scores of the employees stating that their incomes were much lower/lower than their expenditures were higher compared to those stating that their incomes were equal to their expenditures and those stating that their incomes were higher/much higher than their expenditures (p<0.05. CONCLUSION: The findings of the study indicate that factors such as age, education level, status of having children, economic status, and working years were effective on the burnout levels of the employees while the risk area where the workshop was located did not affect the burnout level. [TAF Prev Med Bull 2010; 9(5.000: 453-462

  13. Abatement of malodorants from pesticide factory in dielectric barrier discharges

    International Nuclear Information System (INIS)

    Chen Jie; Yang Jiantao; Pan Hua; Su Qingfa; Liu Yamin; Shi Yao

    2010-01-01

    Traditional odor control methods are limitative technically and economically for the abatement of odor from pesticide factory due to its toxicity and complicated composition. Non-thermal plasma (NTP) methods, typically characterized by high removal efficiency, energy yields and good economy, offer possible alternative solutions. This paper provides laboratory scale experimental data on the removal of simulated odors from pesticide factory with various humidity (0-0.8 vol%) and oxygen contents (0-21%) by a dielectric barrier discharge (DBD) reactor. Peak voltage and initial dimethylamine (DML) concentration are important factors that influence the DML removal efficiency and energy yield. The conversion of DML of 761 mg/m 3 reaches 100% at a peak voltage of 41.25 kV. Under the experiment conditions, the conversion of DML increases with an increase of oxygen contents. And the highest DML conversion was achieved with the gas stream containing 0.3% water. Simultaneously, the concentration of O 3 and OH radical in reactor was measured. Higher conversion, higher energy yield and fewer byproducts were found in mixed odor (DML + dimethyl sulfide (DMS)) treatment than that in single odor treatment. The energy yield is promoted from 2.13 to 5.20 mg/kJ.

  14. Status of neutrino factory and muon collider R and D

    International Nuclear Information System (INIS)

    Zisman, M.S.

    2001-01-01

    A significant worldwide R and D effort is presently directed toward solving the technical challenges of producing, cooling, accelerating, storing, and eventually colliding beams of muons. Its primary thrust is toward issues critical to a Neutrino Factory, for which R and D efforts are under way in the U.S., via the Neutrino Factory and Muon Collider Collaboration (MC); in Europe, centered at CERN; and in Japan, at KEK. Under study and experimental development are production targets handling intense proton beams (1-4 MW), phase rotation systems to reduce beam energy spread, cooling channels to reduce transverse beam emittance for the acceleration system, and storage rings where muon decays in a long straight section provide a neutrino beam for a long-baseline (3000 km) experiment. Critical experimental activities include development of very high gradient normal conducting RF (NCRF) and superconducting RF (SCRF) cavities, high-power liquid-hydrogen absorbers, and high-field superconducting solenoids. Components and instrumentation that tolerate the intense decay products of the muon beam are being developed for testing. For a high-luminosity collider, muons must be cooled longitudinally as well as transversely, requiring an emittance exchange scheme. In addition to the experimental R and D effort, sophisticated theoretical and simulation tools are needed for the design. Here, the goals, present status, and future R and D plans in these areas will be described

  15. Análisis factorial de correspondencias intraclases ponderado

    Directory of Open Access Journals (Sweden)

    Belén Castro Íñigo

    2009-02-01

    Full Text Available En este artículo se presenta una técnica de Análisis Factorial útil para el estudio de tablas de datos en las que existe una partición sobre el conjunto de individuos, definida de forma natural. Dicha técnica permite poner de manifiesto las relaciones existentes entre los individuos, pertenecientes a una misma clase, discriminándolos, a su vez, de los componentes de otras clases por los pesos relativos que se asignen a las mismas. Con una selección apropiada de la ponderación asignada a cada clase, la nueva metodología obtiene las variables locales del Análisis Parcial, contando con la ventaja sobre éste de proporcionar una representación de los individuos, como elementos activos, en los ejes locales. Palabras clave: Análisis Factorial de Correspondencias condicionado a un grafo, Grafo de Partición, Inercia Intraclases, Análisis de Diferencias Locales.

  16. Circular Higgs Factories & Possible Long-Term Strategy

    CERN Document Server

    Zimmermann, F

    2013-01-01

    In 2012 two LHC experiments have discovered a new particle with a mass around 125 GeV, which appears to be the scalar Higgs boson of the Standard Model. To further examine this remarkable particle it could be produced in large numbers for precision studies by an e+e− collider operating near the ZH threshold at beam energies of 120 GeV, or, in the s-channel by a gamma-gamma collider with primary electron beam energies of 80 GeV, or by a high-energy electron-proton collider. In this talk I will discuss tentative design parameters, novel concepts and accelerator-physics challenges (1) for a high-luminosity lepton-hadron collider, bringing into collision a 60-GeV electron beam from an energy-recovery electron linac with one of the LHC hadron beams – LHeC –, (2) for a gamma-gamma Higgs-factory collider based on the reconfigured recirculating SC electron linac – SAPPHiRE – and (3) for a circular e+e− Higgs-factory collider in a new tunnel with a circumference of 80-100 km – TLEP. I will also discuss f...

  17. An artificial reality environment for remote factory control and monitoring

    Science.gov (United States)

    Kosta, Charles Paul; Krolak, Patrick D.

    1993-01-01

    Work has begun on the merger of two well known systems, VEOS (HITLab) and CLIPS (NASA). In the recent past, the University of Massachusetts Lowell developed a parallel version of NASA CLIPS, called P-CLIPS. This modification allows users to create smaller expert systems which are able to communicate with each other to jointly solve problems. With the merger of a VEOS message system, PCLIPS-V can now act as a group of entities working within VEOS. To display the 3D virtual world we have been using a graphics package called HOOPS, from Ithaca Software. The artificial reality environment we have set up contains actors and objects as found in our Lincoln Logs Factory of the Future project. The environment allows us to view and control the objects within the virtual world. All communication between the separate CLIPS expert systems is done through VEOS. A graphical renderer generates camera views on X-Windows devices; Head Mounted Devices are not required. This allows more people to make use of this technology. We are experimenting with different types of virtual vehicles to give the user a sense that he or she is actually moving around inside the factory looking ahead through windows and virtual monitors.

  18. Measurement of Employability Skills on Teaching Factory Learning

    Science.gov (United States)

    Subekti, S.; Ana, A.

    2018-02-01

    Vocational High Schools as one of the educational institutions that has the responsibility in preparing skilled labors has a challenge to improve the quality of human resources as a candidate for skilled labors, to compete and survive in a changing climate of work. BPS noted an increase in the number of non-worker population (BAK) in 2015-2017 on vocational graduates as many as 564,272 people. The ability to adapt and maintain jobs in a variety of conditions is called employability skills. This study purpose to measure the development of employability skills of communication skills, problem-solving skills and teamwork skills on the implementation of teaching factory learning in SMK Negeri 1 Cibadak, THPH Skills Program on bakery competency. This research uses mixed method, with concurrent triangulation mix methods research design. Data collection techniques used interviews and questionnaires. The result shows that there are increasing students’ employability skills in communication skills, problem solving skills, and teamwork skills in teaching factory learning. Principles of learning that apply learning by doing student centering and learning arrangements such as situations and conditions in the workplace have an impact on improving student employability skills.

  19. DKIST enclosure modeling and verification during factory assembly and testing

    Science.gov (United States)

    Larrakoetxea, Ibon; McBride, William; Marshall, Heather K.; Murga, Gaizka

    2014-08-01

    The Daniel K. Inouye Solar Telescope (DKIST, formerly the Advanced Technology Solar Telescope, ATST) is unique as, apart from protecting the telescope and its instrumentation from the weather, it holds the entrance aperture stop and is required to position it with millimeter-level accuracy. The compliance of the Enclosure design with the requirements, as of Final Design Review in January 2012, was supported by mathematical models and other analyses which included structural and mechanical analyses (FEA), control models, ventilation analysis (CFD), thermal models, reliability analysis, etc. During the Enclosure Factory Assembly and Testing the compliance with the requirements has been verified using the real hardware and the models created during the design phase have been revisited. The tests performed during shutter mechanism subsystem (crawler test stand) functional and endurance testing (completed summer 2013) and two comprehensive system-level factory acceptance testing campaigns (FAT#1 in December 2013 and FAT#2 in March 2014) included functional and performance tests on all mechanisms, off-normal mode tests, mechanism wobble tests, creation of the Enclosure pointing map, control system tests, and vibration tests. The comparison of the assumptions used during the design phase with the properties measured during the test campaign provides an interesting reference for future projects.

  20. Effects of the Factory Reset on Mobile Devices

    Directory of Open Access Journals (Sweden)

    Riqui Schwamm

    2014-09-01

    Full Text Available Mobile devices usually provide a “factory-reset” tool to erase user-specific data from the main secondary storage. 9 Apple iPhones, 10 Android devices, and 2 BlackBerry devices were tested in the first systematic evaluation of the effectiveness of factory resets. Tests used the Cellebrite UME-36 Pro with the UFED Physical Analyzer, the Bulk Extractor open-source tool, and our own programs for extracting metadata, classifying file paths, and comparing them between images. Two phones were subjected to more detailed analysis. Results showed that many kinds of data were removed by the resets, but much user-specific configuration data was left. Android devices did poorly at removing user documents and media, and occasional surprising user data was left on all devices including photo images, audio, documents, phone numbers, email addresses, geolocation data, configuration data, and keys. A conclusion is that reset devices can still provide some useful information to a forensic investigation.