Multi-Robot Assembly Strategies and Metrics.

Science.gov (United States)

Marvel, Jeremy A; Bostelman, Roger; Falco, Joe

2018-02-01

We present a survey of multi-robot assembly applications and methods and describe trends and general insights into the multi-robot assembly problem for industrial applications. We focus on fixtureless assembly strategies featuring two or more robotic systems. Such robotic systems include industrial robot arms, dexterous robotic hands, and autonomous mobile platforms, such as automated guided vehicles. In this survey, we identify the types of assemblies that are enabled by utilizing multiple robots, the algorithms that synchronize the motions of the robots to complete the assembly operations, and the metrics used to assess the quality and performance of the assemblies.

Design of the MYRRHA Spallation Target Assembly

International Nuclear Information System (INIS)

Keijers, S.; Fernandez, R.; Stankovskiy, A.; Kennedy, G.; Van Tichelen, K.

2015-01-01

MYRRHA (Multi-purpose hybrid Research Reactor for High-tech Applications) is a multi-purpose research facility currently being developed at SCK.CEN. MYRRHA is based on the ADS (Accelerator Driven System) concept where a proton accelerator, a spallation target and a subcritical reactor are coupled. MYRRHA will demonstrate the ADS full concept by coupling these three components at a reasonable power level. As a flexible irradiation facility, the MYRRHA research reactor will be able to work in both critical and subcritical modes. In this way, MYRRHA will allow fuel developments for innovative reactor systems, material research for GEN IV and fusion reactors, and radioisotope production for medical and industrial applications. MYRRHA will be cooled by Lead Bismuth Eutectic (LBE) and will play an important role in the development of the Pb-alloys technology needed for the LFR (Lead Fast Reactor) GEN IV concept. This paper describes the evolution of the MYRRHA spallation target design. In the early phase of the MYRRHA project (XT-ADS), the target design was based on a dedicated spallation loop inside the primary reactor vessel. Within the core, the 3 central fuel assembly positions were occupied by the spallation target, which enabled a windowless design created by a free surface of LBE facing the proton beam. The windowless option was preferred because of high heat loads in combination with severe irradiation damage in the target region would result in unacceptably short lifetimes of a target window. The LBE in the loop served as spallation target and as target coolant, but was separated from the LBE cooling the reactor core. The loop was equipped with its own pump, heat exchanger and conditioning system. The change from cyclotron to linear accelerator allowed the increase in proton energy from 350 MeV to 600 MeV. This modification led to an important reduction of the specific heat load at the target level and an improvement of the neutronic performance. In addition to

Layered Multi-mode Optimal Control Strategy for Multi-MW Wind Turbine

Institute of Scientific and Technical Information of China (English)

KONG Yi-gang; WANG Zhi-xin

2008-01-01

The control strategy is one of the most important renewable technology, and an increasing number of multi-MW wind turbines are being developed with a variable speed-variable pitch (VS-VP) technology. The main objective of adopting a VS-VP technology is to improve the fast response speed and capture maximum energy. But the power generated by wind turbine changes rapidly because of the centinuous fluctuation of wind speed and direction. At the same time, wind energy conversion systems are of high order, time delays and strong nonlinear characteristics because of many uncertain factors. Based on analyzing the all dynamic processes of wind turbine, a kind of layered multi-mode optimal control strategy is presented which is that three control strategies: bang-bang, fuzzy and adaptive proportienai integral derivative (PID) are adopted according to different stages and expected performance of wind turbine to capture optimum wind power, compensate the nonlinearity and improve the wind turbine performance at low, rated and high wind speed.

Targeted assembly of short sequence reads.

Directory of Open Access Journals (Sweden)

René L Warren

Full Text Available As next-generation sequence (NGS production continues to increase, analysis is becoming a significant bottleneck. However, in situations where information is required only for specific sequence variants, it is not necessary to assemble or align whole genome data sets in their entirety. Rather, NGS data sets can be mined for the presence of sequence variants of interest by localized assembly, which is a faster, easier, and more accurate approach. We present TASR, a streamlined assembler that interrogates very large NGS data sets for the presence of specific variants by only considering reads within the sequence space of input target sequences provided by the user. The NGS data set is searched for reads with an exact match to all possible short words within the target sequence, and these reads are then assembled stringently to generate a consensus of the target and flanking sequence. Typically, variants of a particular locus are provided as different target sequences, and the presence of the variant in the data set being interrogated is revealed by a successful assembly outcome. However, TASR can also be used to find unknown sequences that flank a given target. We demonstrate that TASR has utility in finding or confirming genomic mutations, polymorphisms, fusions and integration events. Targeted assembly is a powerful method for interrogating large data sets for the presence of sequence variants of interest. TASR is a fast, flexible and easy to use tool for targeted assembly.

Target Assembly Facility

Data.gov (United States)

Federal Laboratory Consortium — The Target Assembly Facility integrates new armor concepts into actual armored vehicles. Featuring the capability ofmachining and cutting radioactive materials, it...

MEGAPIE, a 1 MW pilot experiment for a liquid metal spallation target

Energy Technology Data Exchange (ETDEWEB)

Bauer, G.S. [Paul Scherrer Institut, Spallation Neutron Source Division, Villigen-PSI (Switzerland); Salvatores, M. [CEA Cadarache, Direction des Reacteurs Nucleaires, Saint-Paul-lez-Durance Cedex (France); Heusener, G. [Forschungszentrum Karlsruhe, Projekt Nukleare Sicherheitsforschung, Karlsruhe (Germany)

2001-03-01

MEGAPIE (Megawatt Pilot Target Experiment) is an initiative launched by Commissariat a l'Energie Atomique, Cadarache (France) and Forschungszentrum Karlsruhe (Germany) in collaboration with Paul Scherrer Institut (Switzerland), to demonstrate, in an international collaboration, the feasibility of a liquid lead bismuth target for spallation facilities at a beam power level of 1 MW. Such a target is under consideration for various concepts of accelerator driven systems (ADS) to be used in transmutation of nuclear waste and other applications world-wide. It also has the potential of increasing significantly the thermal neutron flux available at the spallation neutron source (SINQ) for neutron scattering. SINQ's beam power being close to 1 MW already, this facility offers a unique opportunity to realize such an experiment with a reasonably small number of new ancillary systems. The paper describes the basic features of the experiment and its boundary conditions, the technical concept of the target and underlying research carried out at participating laboratories. (author)

MEGAPIE, a 1 MW pilot experiment for a liquid metal spallation target

International Nuclear Information System (INIS)

Bauer, G.S.; Salvatores, M.; Heusener, G.

2001-01-01

MEGAPIE (Megawatt Pilot Target Experiment) is an initiative launched by Commissariat a l'Energie Atomique, Cadarache (France) and Forschungszentrum Karlsruhe (Germany) in collaboration with Paul Scherrer Institut (Switzerland), to demonstrate, in an international collaboration, the feasibility of a liquid lead bismuth target for spallation facilities at a beam power level of 1 MW. Such a target is under consideration for various concepts of accelerator driven systems (ADS) to be used in transmutation of nuclear waste and other applications world-wide. It also has the potential of increasing significantly the thermal neutron flux available at the spallation neutron source (SINQ) for neutron scattering. SINQ's beam power being close to 1 MW already, this facility offers a unique opportunity to realize such an experiment with a reasonably small number of new ancillary systems. The paper describes the basic features of the experiment and its boundary conditions, the technical concept of the target and underlying research carried out at participating laboratories. (author)

NIF Target Assembly Metrology Methodology and Results

Energy Technology Data Exchange (ETDEWEB)

Alger, E. T. [General Atomics, San Diego, CA (United States); Kroll, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dzenitis, E. G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Montesanti, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Hughes, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Swisher, M. [IAP, Livermore, CA (United States); Taylor, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Segraves, K. [IAP, Livermore, CA (United States); Lord, D. M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Reynolds, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Castro, C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Edwards, G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2011-01-01

During our inertial confinement fusion (ICF) experiments at the National Ignition Facility (NIF) we require cryogenic targets at the 1-cm scale to be fabricated, assembled, and metrologized to micron-level tolerances. During assembly of these ICF targets, there are physical dimensmetrology is completed using optical coordinate measurement machines that provide repeatable measurements with micron precision, while also allowing in-process data collection for absolute accuracy in assembly. To date, 51 targets have been assembled and metrologized, and 34 targets have been successfully fielded on NIF relying on these metrology data. In the near future, ignition experiments on NIF will require tighter tolerances and more demanding target assembly and metrology capability. Metrology methods, calculations, and uncertainty estimates will be discussed. Target diagnostic port alignment, target position, and capsule location results will be reviewed for the 2009 Energetics Campaign. The information is presented via control charts showing the effect of process improvements that were made during target production. Certain parameters, including capsule position, met the 2009 campaign specifications but will have much tighter requirements in the future. Finally, in order to meet these new requirements assembly process changes and metrology capability upgrades will be necessary.

Dynamic Multi-Component Hemiaminal Assembly

Science.gov (United States)

You, Lei; Long, S. Reid; Lynch, Vincent M.

2012-01-01

A simple approach to generating in situ metal templated tris-(2-picolyl)amine-like multi-component assemblies with potential applications in molecular recognition and sensing is reported. The assembly is based on the reversible covalent association between di-(2-picolyl)amine and aldehydes. Zinc ion is the best for inducing assembly among the metal salts investigated, while 2-picolinaldehyde is the best among the heterocyclic aldehydes studied. Although an equilibrium constant of 6.6 * 103 M-1 was measured for the assembly formed by 2-picolinaldehdye, di-(2-picolyl)amine, and zinc triflate, the equilibrium constants for other systems are in the 102 M-1 range. X-ray structural analysis revealed that zinc adopts a trigonal bipyramidal geometry within the assembled ligand. The diversity and equilibrium of the assemblies are readily altered by simply changing concentrations, varying components, or adding counter anions. PMID:21919095

CT Performance Evaluation Using Multi Material Assemblies

DEFF Research Database (Denmark)

Stolfi, Alessandro; De Chiffre, Leonardo

2015-01-01

This paper concerns an investigation of the accuracy of Computed Tomography measurements using multi-material assemblies. In this study, assemblies involving similar densities for elementary parts were considered. The investigation includes dimensional and geometrical measurements of two 10 mm high...

A biomimetic colorimetric logic gate system based on multi-functional peptide-mediated gold nanoparticle assembly.

Science.gov (United States)

Li, Yong; Li, Wang; He, Kai-Yu; Li, Pei; Huang, Yan; Nie, Zhou; Yao, Shou-Zhuo

2016-04-28

In natural biological systems, proteins exploit various functional peptide motifs to exert target response and activity switch, providing a functional and logic basis for complex cellular activities. Building biomimetic peptide-based bio-logic systems is highly intriguing but remains relatively unexplored due to limited logic recognition elements and complex signal outputs. In this proof-of-principle work, we attempted to address these problems by utilizing multi-functional peptide probes and the peptide-mediated nanoparticle assembly system. Here, the rationally designed peptide probes function as the dual-target responsive element specifically responsive to metal ions and enzymes as well as the mediator regulating the assembly of gold nanoparticles (AuNPs). Taking advantage of Zn2+ ions and chymotrypsin as the model inputs of metal ions and enzymes, respectively, we constructed the peptide logic system computed by the multi-functional peptide probes and outputted by the readable colour change of AuNPs. In this way, the representative binary basic logic gates (AND, OR, INHIBIT, NAND, IMPLICATION) have been achieved by delicately coding the peptide sequence, demonstrating the versatility of our logic system. Additionally, we demonstrated that the three-input combinational logic gate (INHIBIT-OR) could also be successfully integrated and applied as a multi-tasking biosensor for colorimetric detection of dual targets. This nanoparticle-based peptide logic system presents a valid strategy to illustrate peptide information processing and provides a practical platform for executing peptide computing or peptide-related multiplexing sensing, implying that the controllable nanomaterial assembly is a promising and potent methodology for the advancement of biomimetic bio-logic computation.

A triple axes multiple target holder assembly

International Nuclear Information System (INIS)

Tribedi, L.C.; Narvekar, S.D.; Pillay, R.G.; Tandon, P.N.

1993-01-01

We have designed and fabricated a rotatable target holder assembly capable of accommodating 27 targets. The target foils are mounted along two concentric circles on a ss wheel. On the outer circle 18 targets can be mounted each 20deg apart, and on the inner circle the remaining targets are positioned each 40deg apart. The self supporting or carbon backed targets are mounted on thin frames and are placed concentrically at the targets are mounted on thin frames and are placed concentrically at the target position on the wheel. Three degrees of freedom are provided to the target holder assembly. (author). 1 fig

Induced radioactivity in a 4 MW target and its surroundings

CERN Document Server

Agosteo, Stefano; Otto, Thomas; Silari, Marco

2003-01-01

An important aspect of a future CERN Neutrino Factory is the material activation arising from a 2.2 GeV, 4 MW proton beam striking a mercury target. An estimation of the hadronic inelastic interactions and the production of residual nuclei in the target, the magnetic horn, the decay tunnel, the surrounding rock and a downstream dump was performed by the Monte Carlo hadronic cascade code FLUKA. The aim was both to assess the dose equivalent rate to be expected during maintenance work and to evaluate the amount of residual radioactivity, which will have to be disposed of after the facility has ceased operation.

Quantitative self-assembly prediction yields targeted nanomedicines

Science.gov (United States)

Shamay, Yosi; Shah, Janki; Işık, Mehtap; Mizrachi, Aviram; Leibold, Josef; Tschaharganeh, Darjus F.; Roxbury, Daniel; Budhathoki-Uprety, Januka; Nawaly, Karla; Sugarman, James L.; Baut, Emily; Neiman, Michelle R.; Dacek, Megan; Ganesh, Kripa S.; Johnson, Darren C.; Sridharan, Ramya; Chu, Karen L.; Rajasekhar, Vinagolu K.; Lowe, Scott W.; Chodera, John D.; Heller, Daniel A.

2018-02-01

Development of targeted nanoparticle drug carriers often requires complex synthetic schemes involving both supramolecular self-assembly and chemical modification. These processes are generally difficult to predict, execute, and control. We describe herein a targeted drug delivery system that is accurately and quantitatively predicted to self-assemble into nanoparticles based on the molecular structures of precursor molecules, which are the drugs themselves. The drugs assemble with the aid of sulfated indocyanines into particles with ultrahigh drug loadings of up to 90%. We devised quantitative structure-nanoparticle assembly prediction (QSNAP) models to identify and validate electrotopological molecular descriptors as highly predictive indicators of nano-assembly and nanoparticle size. The resulting nanoparticles selectively targeted kinase inhibitors to caveolin-1-expressing human colon cancer and autochthonous liver cancer models to yield striking therapeutic effects while avoiding pERK inhibition in healthy skin. This finding enables the computational design of nanomedicines based on quantitative models for drug payload selection.

The multi-interlock and check of logical system for 5 MW low power reactor automatic rod

International Nuclear Information System (INIS)

Li Guangjian; Zhao Zengqiao

1992-01-01

The safety and reliability of the logical system for 5 MW LPR automatic rod are improved, because of using multi-interlock and manual check on line. The design character and function of the logical system are introduced

A target-moderator-reflector concept of the JAERI 5 MW pulsed spallation neutron source

International Nuclear Information System (INIS)

Watanabe, Noboru; Teshigawara, Makoto; Aizawa, Kazuya; Suzuki, Jyunichi; Oyama, Yukio

1998-03-01

In Japan Atomic Energy Research Institute the construction of a 5 MW (short) pulsed spallation neutron source is under planning using a projected high power superconducting proton (or H - ) linac of 8 MW in total beam power. In the present paper we report our consideration on target-moderator-reflector concept, based on the layout of the tentative neutron instruments for the assumed neutron scattering experiments in future. The choice of cold neutron moderators for high resolution and high intensity experiments, thermal and epithermal neutron moderators for high resolution uses was discussed and a reference layout of target-moderator-reflector system was proposed for detailed neutronic calculation and optimization. The proposed system was designed like that it can provide, at least, 30 beam lines for more than 40 instruments. (author)

Field Validation of the Stability Limit of a Multi MW Turbine

Science.gov (United States)

Kallesøe, Bjarne S.; Kragh, Knud A.

2016-09-01

Long slender blades of modern multi-megawatt turbines exhibit a flutter like instability at rotor speeds above a critical rotor speed. Knowing the critical rotor speed is crucial to a safe turbine design. The flutter like instability can only be estimated using geometrically non-linear aeroelastic codes. In this study, the estimated rotor speed stability limit of a 7 MW state of the art wind turbine is validated experimentally. The stability limit is estimated using Siemens Wind Powers in-house aeroelastic code, and the results show that the predicted stability limit is within 5% of the experimentally observed limit.

Design strategies for self-assembly of discrete targets

International Nuclear Information System (INIS)

Madge, Jim; Miller, Mark A.

2015-01-01

Both biological and artificial self-assembly processes can take place by a range of different schemes, from the successive addition of identical building blocks to hierarchical sequences of intermediates, all the way to the fully addressable limit in which each component is unique. In this paper, we introduce an idealized model of cubic particles with patterned faces that allows self-assembly strategies to be compared and tested. We consider a simple octameric target, starting with the minimal requirements for successful self-assembly and comparing the benefits and limitations of more sophisticated hierarchical and addressable schemes. Simulations are performed using a hybrid dynamical Monte Carlo protocol that allows self-assembling clusters to rearrange internally while still providing Stokes-Einstein-like diffusion of aggregates of different sizes. Our simulations explicitly capture the thermodynamic, dynamic, and steric challenges typically faced by self-assembly processes, including competition between multiple partially completed structures. Self-assembly pathways are extracted from the simulation trajectories by a fully extendable scheme for identifying structural fragments, which are then assembled into history diagrams for successfully completed target structures. For the simple target, a one-component assembly scheme is most efficient and robust overall, but hierarchical and addressable strategies can have an advantage under some conditions if high yield is a priority

Investigation of IFMIF target assembly structure design

International Nuclear Information System (INIS)

Ida, Mizuho; Nakamura, Hiroo; Sugimoto, Masayoshi; Yamamura, Toshio

2006-10-01

In the International Fusion Materials Irradiation Facility (IFMIF), the back-wall of target assembly is the part suffered the highest neutron-flux. The back-wall and the assembly are designed to have lips for cutting/welding at the back-wall replacement. To reduce thermal stress and deformation of the back-wall under neutron irradiation, contact pressure between the back-wall and the assembly is one of dominant factors. Therefore, an investigation was performed for feasible clamping pressure of a mechanical clamp set in limited space around the back-wall. It was clarified that the clamp can give a pressure difference up to 0.4 MPa between the contact pressure and atmosphere pressure in the test cell room. Also a research was performed for the dissimilar metal welding in the back-wall. Use of 309 steel was found adequate as the intermediate filler metal through the research of previous welding. Maintaining a temperature of the target assembly so as to avoid a freezing of liquid lithium is needed at the lithium charge into the loop before the beam injection. The assembly is covered with thermal insulation. Therefore, a research and an investigation were performed for compact and light thermal-insulation effective even under helium (i.e. high heat-conduction) condition of the test cell room. The result was as follows; in the case that a thermal conductivity 0.008 W/m·K of one of found insulation materials is available in the temperature range up to 300degC of the IFMIF target assembly, needed thickness and weight of the insulation were respectively only 8.2 mm and 32 kg. Also a research was performed for high-heat-density heaters to maintain temperature of the back-wall which can not be cover with insulation due to limited space. A heater made of silicon-nitride was found to be adequate. Total heat of 8.4 kW on the back-wall was found to be achievable through an investigations of heater arrange. Also an investigation was performed for remote-handling device to

Box-Particle Cardinality Balanced Multi-Target Multi-Bernoulli Filter

OpenAIRE

L. Song; X. Zhao

2014-01-01

As a generalized particle filtering, the box-particle filter (Box-PF) has a potential to process the measurements affected by bounded error of unknown distributions and biases. Inspired by the Box-PF, a novel implementation for multi-target tracking, called box-particle cardinality balanced multi-target multi-Bernoulli (Box-CBMeMBer) filter is presented in this paper. More important, to eliminate the negative effect of clutters in the estimation of the numbers of targets, an improved generali...

Rationale for a spallation neutron source target system test facility at the 1-MW Long-Pulse Spallation Source

International Nuclear Information System (INIS)

Sommer, W.F.

1995-12-01

The conceptual design study for a 1-MW Long-Pulse Spallation Source at the Los Alamos Neutron Science Center has shown the feasibility of including a spallation neutron test facility at a relatively low cost. This document presents a rationale for developing such a test bed. Currently, neutron scattering facilities operate at a maximum power of 0.2 MW. Proposed new designs call for power levels as high as 10 MW, and future transmutation activities may require as much as 200 MW. A test bed will allow assessment of target neutronics; thermal hydraulics; remote handling; mechanical structure; corrosion in aqueous, non-aqueous, liquid metal, and molten salt systems; thermal shock on systems and system components; and materials for target systems. Reliable data in these areas are crucial to the safe and reliable operation of new high-power facilities. These tests will provide data useful not only to spallation neutron sources proposed or under development, but also to other projects in accelerator-driven transmutation technologies such as the production of tritium

Controlled assembly of multi-segment nanowires by histidine-tagged peptides

Energy Technology Data Exchange (ETDEWEB)

Wang, Aijun A; Lee, Joun; Jenikova, Gabriela; Mulchandani, Ashok; Myung, Nosang V; Chen, Wilfred [Department of Chemical and Environmental Engineering, University of California, Riverside, CA 92521 (United States)

2006-07-28

A facile technique was demonstrated for the controlled assembly and alignment of multi-segment nanowires using bioengineered polypeptides. An elastin-like-polypeptide (ELP)-based biopolymer consisting of a hexahistine cluster at each end (His{sub 6}-ELP-His{sub 6}) was generated and purified by taking advantage of the reversible phase transition property of ELP. The affinity between the His{sub 6} domain of biopolymers and the nickel segment of multi-segment nickel/gold/nickel nanowires was exploited for the directed assembly of nanowires onto peptide-functionalized electrode surfaces. The presence of the ferromagnetic nickel segments on the nanowires allowed the control of directionality by an external magnetic field. Using this method, the directed assembly and positioning of multi-segment nanowires across two microfabricated nickel electrodes in a controlled manner was accomplished with the expected ohmic contact.

XML-based assembly visualization for a multi-CAD digital mock-up system

International Nuclear Information System (INIS)

Song, In Ho; Chung, Sung Chong

2007-01-01

Using a virtual assembly tool, engineers are able to design accurate and interference free parts without making physical mock-ups. Instead of a single CAD source, several CAD systems are used to design a complex product in a distributed design environment. In this paper, a multi-CAD assembly method is proposed through an XML and the lightweight CAD file. XML data contains a hierarchy of the multi-CAD assembly. The lightweight CAD file produced from various CAD files through the ACIS kemel and InterOp includes not only mesh and B-Rep data, but also topological data. It is used to visualize CAD data and to verify dimensions of the parts. The developed system is executed on desktop computers. It does not require commercial CAD systems to visualize 3D assembly data. Multi-CAD models have been assembled to verify the effectiveness of the developed DMU system on the Internet

Thermal analysis of multi-MW two-level wind power converter

DEFF Research Database (Denmark)

Zhou, Dao; Blaabjerg, Frede; Mogens, Lau

2012-01-01

In this paper, the multi-MW wind turbine of partial-scale and full-scale two-level power converter with DFIG and direct-drive PMSG are designed and compared in terms of their thermal performance. Simulations of different configurations regarding loss distribution and junction temperature...... in the power device in the whole range of wind speed are presented and analyzed. It is concluded that in both partial-scale and full-scale power converter the most thermal stressed power device in the generator-side converter will have higher mean junction temperature and larger junction temperature...... fluctuation compared to grid-side converter at the rated wind speed. Moreover, the thermal performance of the generator-side converter in the partial-scale power converter becomes crucial around the synchronous operating point and should be considered carefully....

EURISOL-DS multi-MW target unit: Neutronics performance and shielding assessment, dose rate and material activation calculations for the MAFF configuration

CERN Document Server

Romanets, Y; Kadi, Y; Luis, R; Goncalves, I F; Tecchio, L; Kharoua, C; Vaz, P; Ene, D; David, J C; Rocca, R; Negoita, F

2010-01-01

One of the objectives of the EURISOL (EURopean Isotope Separation On-Line Radioactive Ion Beam) Design Study consisted of providing a safe and reliable facility layout and design for the following operational parameters and characteristics: (a) a 4 MW proton beam of 1 GeV energy impinging on a mercury target (the converter); (b) high neutron fluxes (similar to 3 x 10(16) neutrons/s) generated by spallation reactions of the protons impinging in the converter and (c) fission rate on fissile U-235 targets in excess of 10(15) fissions/s. In this work, the state-of-the-art Monte Carlo codes MCNPX (Pelowitz, 2005) and FLUKA (Vlachoudis, 2009; Ferrari et al., 2008) were used to characterize the neutronics performance and to perform the shielding assessment (Herrera-Martinez and Kadi, 2006; Cornell, 2003) of the EURISOLTarget Unit and to provide estimations of dose rate and activation of different components, in view of the radiation safety assessment of the facility. Dosimetry and activation calculations were perfor...

Multi-target consensus circle pursuit for multi-agent systems via a distributed multi-flocking method

Science.gov (United States)

Pei, Huiqin; Chen, Shiming; Lai, Qiang

2016-12-01

This paper studies the multi-target consensus pursuit problem of multi-agent systems. For solving the problem, a distributed multi-flocking method is designed based on the partial information exchange, which is employed to realise the pursuit of multi-target and the uniform distribution of the number of pursuing agents with the dynamic target. Combining with the proposed circle formation control strategy, agents can adaptively choose the target to form the different circle formation groups accomplishing a multi-target pursuit. The speed state of pursuing agents in each group converges to the same value. A Lyapunov approach is utilised to analyse the stability of multi-agent systems. In addition, a sufficient condition is given for achieving the dynamic target consensus pursuit, and which is then analysed. Finally, simulation results verify the effectiveness of the proposed approaches.

PMHT Approach for Multi-Target Multi-Sensor Sonar Tracking in Clutter.

Science.gov (United States)

Li, Xiaohua; Li, Yaan; Yu, Jing; Chen, Xiao; Dai, Miao

2015-11-06

Multi-sensor sonar tracking has many advantages, such as the potential to reduce the overall measurement uncertainty and the possibility to hide the receiver. However, the use of multi-target multi-sensor sonar tracking is challenging because of the complexity of the underwater environment, especially the low target detection probability and extremely large number of false alarms caused by reverberation. In this work, to solve the problem of multi-target multi-sensor sonar tracking in the presence of clutter, a novel probabilistic multi-hypothesis tracker (PMHT) approach based on the extended Kalman filter (EKF) and unscented Kalman filter (UKF) is proposed. The PMHT can efficiently handle the unknown measurements-to-targets and measurements-to-transmitters data association ambiguity. The EKF and UKF are used to deal with the high degree of nonlinearity in the measurement model. The simulation results show that the proposed algorithm can improve the target tracking performance in a cluttered environment greatly, and its computational load is low.

Instrumentation Around the ESS 5 MW Spallation Tungsten Target Submitted to 2 GeV Proton Pulses

International Nuclear Information System (INIS)

Shea, Thomas; Plewinski, Francois; Nordt, Annika; Sadeghzadeh, Atefeh; Linander, Rikard; Kharoua, Cyril

2013-06-01

The 5 MW European Spallation Source, currently in its design phase, includes a linear proton accelerator sending a 2.86 ms long pulse of 2 GeV protons at 14 Hz to a tungsten target. This spallation source distributes thermal and cold neutron beams to a large variety of state-of-the-art neutron instruments, supported by a suite of laboratories and a supercomputing data management and software development center. The target is a rotating wheel 2.5 m in diameter composed of helium cooled tungsten plates and produces high intensity gamma and fast neutron pulses (higher than 2E15 n/cm 2 /s). This paper focuses on the design of 2 types of instrumentation: to monitor target operation and to control the proton beam parameters. Instrumentation mounted on the rotating target (designed for a minimum lifetime of 5 years) to monitor the helium coolant flow and the evolution of irradiated tungsten plates and the target vessel, the target balance, vibrations and displacement is presented as well as a dedicated instrumentation plug installed at opposite the impinging proton beam, which will monitor the target wheel with an LDV and an infra-red camera and perform gamma scanning during and after irradiation. Upstream of the target, a suite of instrumentation will monitor the properties of the 2 GeV proton beam. This suite will consist of imaging devices and multi-wire grids to monitor the beam density distribution at the proton beam window and at the target. An additional imaging system will observe luminescence from the Helium gas between the proton beam window and the target. Beam halo will be monitored by thermocouples located near the edge of the aperture. Further upstream, electromagnetic pickups will measure the beam centroid position, the beam current, and the beam pulse's time of arrival. This time-of-arrival signal will allow precise synchronization of the target's rotation and the beam pulse structure. (authors)

Brief introduction to 60 MW CARR

Energy Technology Data Exchange (ETDEWEB)

Tonghua, Yang; Chuntang, Ye [China Inst. of Atomic Energy, Beijing BJ (China)

1998-10-01

CARR, a 60 MW reactor will be constructed at China Institute of Atomic Energy (CIAE). The reactor type, its safety features, core lay-out, fuel assemblies, main parameters designed, main applications of are briefly described. (author)

Multi-sensor control for precise assembly of optical components

Directory of Open Access Journals (Sweden)

Ma Li

2014-06-01

Full Text Available In order to perform an optical assembly accurately, a multi-sensor control strategy is developed which includes an attitude measurement system, a vision system, a loss measurement system and a force sensor. A 3-DOF attitude measuring method using linear variable differential transformers (LVDT is designed to adjust the relation of position and attitude between the spherical mirror and the resonator. A micro vision feedback system is set up to extract the light beam and the diaphragm, which can achieve the coarse positioning of the spherical mirror in the optical assembly process. A rapid self-correlation method is presented to analyze the spectrum signal for the fine positioning. In order to prevent the damage of the optical components and realize sealing of the resonator, a hybrid force-position control is constructed to control the contact force of the optical components. The experimental results show that the proposed multi-sensor control strategy succeeds in accomplishing the precise assembly of the optical components, which consists of parallel adjustment, macro coarse adjustment, macro approach, micro fine adjustment, micro approach and optical contact. Therefore, the results validate the multi-sensor control strategy.

Novel multi-biotin grafted poly(lactic acid) and its self-assembling nanoparticles capable of binding to streptavidin

Science.gov (United States)

Yan, Hao; Jiang, Weimin; Zhang, Yinxing; Liu, Ying; Wang, Bin; Yang, Li; Deng, Lihong; Singh, Gurinder K; Pan, Jun

2012-01-01

Targeted drug delivery requires novel biodegradable, specific binding systems with longer circulation time. The aim of this study was to prepare biotinylated poly(lactic acid) (PLA) nanoparticles (NPs) which can meet regular requirements as well conjugate more biotins in the polymer to provide better binding with streptavidin. A biotin-graft-PLA was synthesized based on previously published biodegradable poly(ethylene glycol) (PEG)-graft-PLA, with one polymer molecule containing three PEG molecules. Newly synthesized biotin-graft-PLA had three biotins per polymer molecule, higher than the previous biotinylated PLA (≤1 biotin per polymer molecule). A PEG with a much lower molecular weight (MW ~1900) than the previous biotinylated PLA (PEG MW ≥ 3800), and thus more biocompatible, was used which supplied good nonspecific protein-resistant property compatible to PEG-graft-PLA, suggesting its possible longer stay in the bloodstream. Biotin-graft-PLA specifically bound to streptavidin and self-assembled into NPs, during which naproxen, a model small molecule (MW 230 Da) and hydrophobic drug, was encapsulated (encapsulation efficiency 51.88%). The naproxen-loaded NPs with particle size and zeta potential of 175 nm and −27.35 mV realized controlled release within 170 hours, comparable to previous studies. The biotin-graft-PLA NPs adhered approximately two-fold more on streptavidin film and on biotin film via a streptavidin arm both in static and dynamic conditions compared with PEG-graft-PLA NPs, the proven nonspecific protein-resistant NPs. The specific binding of biotin-graft-PLA NPs with streptavidin and with biotin using streptavidin arm, as well as its entrapment and controlled release for naproxen, suggest potential applications in targeted drug delivery. PMID:22334778

Multi-scale coarse-graining for the study of assembly pathways in DNA-brick self-assembly

Science.gov (United States)

Fonseca, Pedro; Romano, Flavio; Schreck, John S.; Ouldridge, Thomas E.; Doye, Jonathan P. K.; Louis, Ard A.

2018-04-01

Inspired by recent successes using single-stranded DNA tiles to produce complex structures, we develop a two-step coarse-graining approach that uses detailed thermodynamic calculations with oxDNA, a nucleotide-based model of DNA, to parametrize a coarser kinetic model that can reach the time and length scales needed to study the assembly mechanisms of these structures. We test the model by performing a detailed study of the assembly pathways for a two-dimensional target structure made up of 334 unique strands each of which are 42 nucleotides long. Without adjustable parameters, the model reproduces a critical temperature for the formation of the assembly that is close to the temperature at which assembly first occurs in experiments. Furthermore, the model allows us to investigate in detail the nucleation barriers and the distribution of critical nucleus shapes for the assembly of a single target structure. The assembly intermediates are compact and highly connected (although not maximally so), and classical nucleation theory provides a good fit to the height and shape of the nucleation barrier at temperatures close to where assembly first occurs.

Rail-Guided Multi-Robot System for 3D Cellular Hydrogel Assembly with Coordinated Nanomanipulation

Directory of Open Access Journals (Sweden)

Huaping Wang

2014-08-01

Full Text Available The 3D assembly of micro-/nano-building blocks with multi-nanomanipulator coordinated manipulation is one of the central elements of nanomanipulation. A novel rail-guided nanomanipulation system was proposed for the assembly of a cellular vascular-like hydrogel microchannel. The system was equipped with three nanomanipulators and was restricted on the rail in order to realize the arbitrary change of the end-effectors during the assembly. It was set up with hybrid motors to achieve both a large operating space and a 30 nm positional resolution. The 2D components such as the assembly units were fabricated through the encapsulation of cells in the hydrogel. The coordinated manipulation strategies among the multi-nanomanipulators were designed with vision feedback and were demonstrated through the bottom-up assembly of the vascular-like microtube. As a result, the multi-layered microchannel was assembled through the cooperation of the nanomanipulation system.

Wave Dragon MW

DEFF Research Database (Denmark)

Kofoed, Jens Peter; Frigaard, Peter

Wave Dragon is a wave energy converter of the overtopping type. The device has been thoroughly tested on a 1:51.8 scale model in wave laboratories and a 1:4.5 scale model deployed in Nissum Bredning, a large inland waterway in Denmark. Based on the experience gained a full scale, multi MW prototype...

Target Assembly to Check Boresight Alignment of Active Sensors

Science.gov (United States)

Ramos-Izquierdo, Luis; Scott, V. Stanley; Riris, Haris; Cavanaugh, John; Liiva, Peter; Rodriguez, Michael

2011-01-01

A compact and portable target assembly (Fig. 1) has been developed to measure the boresite alignment of LRO's Lunar Orbiter Laser Altimeter (LOLA) instrument at the spacecraft level. The concept for this target assembly has evolved over many years with earlier versions used to test the Mars Observer Laser Altimeter (MOLA), the Geoscience Laser Altimeter System (GLAS), and the Mercury Laser Altimeter (MLA) space-based instruments.

Preliminary Design of a Multi-Column TLP Foundation for a 5-MW Offshore Wind Turbine

OpenAIRE

Yongsheng Zhao; Jianmin Yang; Yanping He

2012-01-01

Currently, floating wind turbines (FWTs) may be the more economical and suitable systems with which to exploit offshore wind energy in deep waters. Among the various types of floating foundations for offshore wind farms, a tension leg platform (TLP) foundation can provide a relatively stable platform for currently available offshore wind turbines without requiring major modifications. In this study, a new multi-column TLP foundation (WindStar TLP) was developed for the NREL 5-MW offshore wind...

Micro-vision servo control of a multi-axis alignment system for optical fiber assembly

International Nuclear Information System (INIS)

Chen, Weihai; Yu, Fei; Qu, Jianliang; Chen, Wenjie; Zhang, Jianbin

2017-01-01

This paper describes a novel optical fiber assembly system featuring a multi-axis alignment function based on micro-vision feedback control. It consists of an active parallel alignment mechanism, a passive compensation mechanism, a micro-gripper and a micro-vision servo control system. The active parallel alignment part is a parallelogram-based design with remote-center-of-motion (RCM) function to achieve precise rotation without fatal lateral motion. The passive mechanism, with five degrees of freedom (5-DOF), is used to implement passive compensation for multi-axis errors. A specially designed 1-DOF micro-gripper mounted onto the active parallel alignment platform is adopted to grasp and rotate the optical fiber. A micro-vision system equipped with two charge-coupled device (CCD) cameras is introduced to observe the small field of view and obtain multi-axis errors for servo feedback control. The two CCD cameras are installed in an orthogonal arrangement—thus the errors can be easily measured via the captured images. Meanwhile, a series of tracking and measurement algorithms based on specific features of the target objects are developed. Details of the force and displacement sensor information acquisition in the assembly experiment are also provided. An experiment demonstrates the validity of the proposed visual algorithm by achieving the task of eliminating errors and inserting an optical fiber to the U-groove accurately. (paper)

Real-Time Multi-Target Localization from Unmanned Aerial Vehicles

Directory of Open Access Journals (Sweden)

Xuan Wang

2016-12-01

Full Text Available In order to improve the reconnaissance efficiency of unmanned aerial vehicle (UAV electro-optical stabilized imaging systems, a real-time multi-target localization scheme based on an UAV electro-optical stabilized imaging system is proposed. First, a target location model is studied. Then, the geodetic coordinates of multi-targets are calculated using the homogeneous coordinate transformation. On the basis of this, two methods which can improve the accuracy of the multi-target localization are proposed: (1 the real-time zoom lens distortion correction method; (2 a recursive least squares (RLS filtering method based on UAV dead reckoning. The multi-target localization error model is established using Monte Carlo theory. In an actual flight, the UAV flight altitude is 1140 m. The multi-target localization results are within the range of allowable error. After we use a lens distortion correction method in a single image, the circular error probability (CEP of the multi-target localization is reduced by 7%, and 50 targets can be located at the same time. The RLS algorithm can adaptively estimate the location data based on multiple images. Compared with multi-target localization based on a single image, CEP of the multi-target localization using RLS is reduced by 25%. The proposed method can be implemented on a small circuit board to operate in real time. This research is expected to significantly benefit small UAVs which need multi-target geo-location functions.

Statistical Methods in Assembly Quality Management of Multi-Element Products on Automatic Rotor Lines

Science.gov (United States)

Pries, V. V.; Proskuriakov, N. E.

2018-04-01

To control the assembly quality of multi-element mass-produced products on automatic rotor lines, control methods with operational feedback are required. However, due to possible failures in the operation of the devices and systems of automatic rotor line, there is always a real probability of getting defective (incomplete) products into the output process stream. Therefore, a continuous sampling control of the products completeness, based on the use of statistical methods, remains an important element in managing the quality of assembly of multi-element mass products on automatic rotor lines. The feature of continuous sampling control of the multi-element products completeness in the assembly process is its breaking sort, which excludes the possibility of returning component parts after sampling control to the process stream and leads to a decrease in the actual productivity of the assembly equipment. Therefore, the use of statistical procedures for continuous sampling control of the multi-element products completeness when assembled on automatic rotor lines requires the use of such sampling plans that ensure a minimum size of control samples. Comparison of the values of the limit of the average output defect level for the continuous sampling plan (CSP) and for the automated continuous sampling plan (ACSP) shows the possibility of providing lower limit values for the average output defects level using the ACSP-1. Also, the average sample size when using the ACSP-1 plan is less than when using the CSP-1 plan. Thus, the application of statistical methods in the assembly quality management of multi-element products on automatic rotor lines, involving the use of proposed plans and methods for continuous selective control, will allow to automating sampling control procedures and the required level of quality of assembled products while minimizing sample size.

Target designs for the Brookhaven National Laboratory 5-MW pulsed spallation neutron source

International Nuclear Information System (INIS)

Ludewig, H.; Todosow, M.; Powell, J.R.

1996-01-01

A feasibility study of a compact high power density target for a spallation neutron source was under-taken. The target arrangement consists primarily of heavy metal, with appropriate cooling passages. A high intensity proton beam of intermediate energy is directed at the target, where it interacts with the heavy metal nuclei. The subsequent spallation reactions produce several neutrons per proton resulting in an intense neutron source. The proton beam is assumed to havean energy of 5 MW, and to be cyclic with a repetition rate of 10Hz and 50Hz. The study was divided into two broad sections. First, an analysis of preliminary target designs was undertaken to ensure the overall feasibility of the concepts involved in the design and eventual construction of such a high power density target. Second, two proposed target designs, based on the first set of analyses, are investigated in more detail. Special care is taken to ensure that the neutron fluxes in the moderator are at the desired level no material compatibility problems exist,and the target is able to operate in a reliable and safe manner. Several target materials, coolant types, and target arrangements are investigated in the first section. The second section concentrates on a single target material and geometric arrangement. However, several structural material choices continue to be investigated with the aim of minimizing the effects of structural heating, and associated thermally induced stresses. In the final section the conclusions of this preliminary study are summarized

Multi-target molecular imaging and its progress in research and application

International Nuclear Information System (INIS)

Tang Ganghua

2011-01-01

Multi-target molecular imaging (MMI) is an important field of research in molecular imaging. It includes multi-tracer multi-target molecular imaging(MTMI), fusion-molecule multi-target imaging (FMMI), coupling-molecule multi-target imaging (CMMI), and multi-target multifunctional molecular imaging(MMMI). In this paper,imaging modes of MMI are reviewed, and potential applications of positron emission tomography MMI in near future are discussed. (author)

Self-Assembling Multi-Component Nanofibers for Strong Bioinspired Underwater Adhesives

Science.gov (United States)

Zhong, Chao; Gurry, Thomas; Cheng, Allen A; Downey, Jordan; Deng, Zhengtao; Stultz, Collin M.; Lu, Timothy K

2014-01-01

Many natural underwater adhesives harness hierarchically assembled amyloid nanostructures to achieve strong and robust interfacial adhesion under dynamic and turbulent environments. Despite recent advances, our understanding of the molecular design, self-assembly, and structure-function relationship of those natural amyloid fibers remains limited. Thus, designing biomimetic amyloid-based adhesives remains challenging. Here, we report strong and multi-functional underwater adhesives obtained from fusing mussel foot proteins (Mfps) of Mytilus galloprovincialis with CsgA proteins, the major subunit of Escherichia coli amyloid curli fibers. These hybrid molecular materials hierarchically self-assemble into higher-order structures, in which, according to molecular dynamics simulations, disordered adhesive Mfp domains are exposed on the exterior of amyloid cores formed by CsgA. Our fibers have an underwater adhesion energy approaching 20.9 mJ/m2, which is 1.5 times greater than the maximum of bio-inspired and bio-derived protein-based underwater adhesives reported thus far. Moreover, they outperform Mfps or curli fibers taken on their own at all pHs and exhibit better tolerance to auto-oxidation than Mfps at pH ≥7.0. This work establishes a platform for engineering multi-component self-assembling materials inspired by nature. PMID:25240674

Optimization of sound absorbing performance for gradient multi-layer-assembled sintered fibrous absorbers

Science.gov (United States)

Zhang, Bo; Zhang, Weiyong; Zhu, Jian

2012-04-01

The transfer matrix method, based on plane wave theory, of multi-layer equivalent fluid is employed to evaluate the sound absorbing properties of two-layer-assembled and three-layer-assembled sintered fibrous sheets (generally regarded as a kind of compound absorber or structures). Two objective functions which are more suitable for the optimization of sound absorption properties of multi-layer absorbers within the wider frequency ranges are developed and the optimized results of using two objective functions are also compared with each other. It is found that using the two objective functions, especially the second one, may be more helpful to exert the sound absorbing properties of absorbers at lower frequencies to the best of their abilities. Then the calculation and optimization of sound absorption properties of multi-layer-assembled structures are performed by developing a simulated annealing genetic arithmetic program and using above-mentioned objective functions. Finally, based on the optimization in this work the thoughts of the gradient design over the acoustic parameters- the porosity, the tortuosity, the viscous and thermal characteristic lengths and the thickness of each samples- of porous metals are put forth and thereby some useful design criteria upon the acoustic parameters of each layer of porous fibrous metals are given while applying the multi-layer-assembled compound absorbers in noise control engineering.

Multi-resolution and multi-scale simulation of the thermal hydraulics in fast neutron reactor assemblies

International Nuclear Information System (INIS)

Angeli, P.-E.

2011-01-01

The present work is devoted to a multi-scale numerical simulation of an assembly of fast neutron reactor. In spite of the rapid growth of the computer power, the fine complete CFD of a such system remains out of reach in a context of research and development. After the determination of the thermalhydraulic behaviour of the assembly at the macroscopic scale, we propose to carry out a local reconstruction of the fine scale information. The complete approach will require a much lower CPU time than the CFD of the entire structure. The macro-scale description is obtained using either the volume averaging formalism in porous media, or an alternative modeling historically developed for the study of fast neutron reactor assemblies. It provides some information used as constraint of a down-scaling problem, through a penalization technique of the local conservation equations. This problem lean on the periodic nature of the structure by integrating periodic boundary conditions for the required microscale fields or their spatial deviation. After validating the methodologies on some model applications, we undertake to perform them on 'industrial' configurations which demonstrate the viability of this multi-scale approach. (author) [fr

Self-assembled peptide-based nanostructures: Smart nanomaterials toward targeted drug delivery.

Science.gov (United States)

Habibi, Neda; Kamaly, Nazila; Memic, Adnan; Shafiee, Hadi

2016-02-01

Self-assembly of peptides can yield an array of well-defined nanostructures that are highly attractive nanomaterials for many biomedical applications such as drug delivery. Some of the advantages of self-assembled peptide nanostructures over other delivery platforms include their chemical diversity, biocompatibility, high loading capacity for both hydrophobic and hydrophilic drugs, and their ability to target molecular recognition sites. Furthermore, these self-assembled nanostructures could be designed with novel peptide motifs, making them stimuli-responsive and achieving triggered drug delivery at disease sites. The goal of this work is to present a comprehensive review of the most recent studies on self-assembled peptides with a focus on their "smart" activity for formation of targeted and responsive drug-delivery carriers.

The new 6 MW industrial gas turbine from MAN; Die neue 6 MW Industriegasturbine von MAN

Energy Technology Data Exchange (ETDEWEB)

Beukenberg, M.; Wiedermann, A.; Orth, U.; Aschenbruck, E.; Reiss, F. [MAN Diesel und Turbo SE, Oberhausen (Germany)

2010-07-01

The development of a completely new series of gas turbines requires significant capital, resources and know-how. MAN Diesel and Turbo strategically decided to create a small gas turbine in the 6 MW-class. The construction of the Gas Turbine has been on the basis of opportunities in current and future markets and the positioning of the competition, this has determined the characteristics and technical parameters which have been optimised in the 6 MW design. The construction uses extremely high precision engineering so that the assembly of sub-components to modules is a smooth flowing process and can guarantee the high standards both quality and performance which MAN Diesel and Turbo are operating to. The individual components must be tested and thoroughly validated many months before actual assembly of the first machine. These include in particular the compressor of the gas turbine and the combustion chamber. The combustion system required special attention, since the emissions are strongly focused to satisfy stringent environmental requirements. The planned tests are a prerequisite for the construction of such a prototype and must be successfully completed before the Gas Turbine will be accepted into service. (orig.)

Single-Molecule Analysis for RISC Assembly and Target Cleavage.

Science.gov (United States)

Sasaki, Hiroshi M; Tadakuma, Hisashi; Tomari, Yukihide

2018-01-01

RNA-induced silencing complex (RISC) is a small RNA-protein complex that mediates silencing of complementary target RNAs. Biochemistry has been successfully used to characterize the molecular mechanism of RISC assembly and function for nearly two decades. However, further dissection of intermediate states during the reactions has been warranted to fill in the gaps in our understanding of RNA silencing mechanisms. Single-molecule analysis with total internal reflection fluorescence (TIRF) microscopy is a powerful imaging-based approach to interrogate complex formation and dynamics at the individual molecule level with high sensitivity. Combining this technique with our recently established in vitro reconstitution system of fly Ago2-RISC, we have developed a single-molecule observation system for RISC assembly. In this chapter, we summarize the detailed protocol for single-molecule analysis of chaperone-assisted assembly of fly Ago2-RISC as well as its target cleavage reaction.

A He-gas Cooled, Stationary Granular Target

CERN Document Server

Pugnat, P

2003-01-01

In the CERN approach to the design of a neutrino factory, the repetition frequency of the proton beam is high enough to consider stationary solid targets as a viable solution for multi-MW beams. The target consists of high density tantalum spheres of 2 mm diameter which can efficiently be cooled by passing a high mass flow He-gas stream through the voids between the Ta-granules. Very small thermal shocks and stresses will arise in this fine grained structure due to the relatively long burst of 3.3 ms from the SPL-proton linac. In a quadruple target system where each target receives only one quarter of the total beam power of 4 MW, conservative temperature levels and adequate lifetimes of the target are estimated in its very high radiation environment. A conceptual design of the integration of the target into the magnetic horn-pion-collector is presented.

Induced radioactivity in the target station and decay tunnel from a 4MW proton beam

CERN Document Server

Agosteo, S; Otto, T; Silari, Marco

2003-01-01

An important aspect of a future CERN Neutrino Factory is the material activation arising from a 2.2 GeV, 4 MW proton beam striking a mercury target. A first estimation of the hadronic inelastic interactions and the production of residual nuclei in the target, the magnetic horn, the decay tunnel, the surrounding rock and a downstream dump has been performed by the Monte Carlo hadronic cascade code FLUKA. The aim is both to assess the dose equivalent rate to be expected during maintenance work and to evaluate the amount of residual radioactivity, which will have to be disposed of after the facility has ceased operation. This paper discusses the first results of such calculations.

Modernization of internal target assembly for AIC-144 cyclotron - proposal

International Nuclear Information System (INIS)

Petelenz, B.; Szalkowski, M.

2007-01-01

The report describes a prototype of the remotely controlled internal target assembly, designed and built in the Institute of Nuclear Physics. After a series of technical tests, the machine was used in 2006 to produce 73 As from proton bombarded germanium targets. Before this, distribution of the proton beam on the target was checked by autoradiography of irradiated copper foils exposed on large area thermoluminescence detectors. Since the experiments exhibited some severe drawbacks of the machine, the report gives hints how to get rid of them, which is the answer to the question asked by the Deputy Director of the Institute on the topic. The construction parts of the assembly are listed in the Chapter 10. (author)

50 MW C-band pulse klystron; 50MW C band pulse klystron

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

C-band pulse klystron E3746 with an output of 50 MW class was developed jointly with the High-Energy Accelerator Research Organization in the Ministry of Education as the klystron for a linear accelerator. For a large-sized linear accelerator in the next generation, a klystron with higher operating frequency has been required to obtain a compact and efficient accelerator. In E3746, the problem of power resistance during high-frequency operation was solved by mounting a traveling-wave multi-cell output circuit. Moreover, stable operation in the pulse width of 2.5 {mu}s and the output of 54 MW was performed at the same operation efficiency (44%) as the conventional S-band tube by using the frequency (in a C-band frequency band) that is two times as high as the conventional general accelerator. (translated by NEDO)

Multi-Robot, Multi-Target Particle Swarm Optimization Search in Noisy Wireless Environments

Energy Technology Data Exchange (ETDEWEB)

Kurt Derr; Milos Manic

2009-05-01

Multiple small robots (swarms) can work together using Particle Swarm Optimization (PSO) to perform tasks that are difficult or impossible for a single robot to accomplish. The problem considered in this paper is exploration of an unknown environment with the goal of finding a target(s) at an unknown location(s) using multiple small mobile robots. This work demonstrates the use of a distributed PSO algorithm with a novel adaptive RSS weighting factor to guide robots for locating target(s) in high risk environments. The approach was developed and analyzed on multiple robot single and multiple target search. The approach was further enhanced by the multi-robot-multi-target search in noisy environments. The experimental results demonstrated how the availability of radio frequency signal can significantly affect robot search time to reach a target.

EURISOL-DS Multi‐MW Target: Radiological Protection, Radiation Safety and Shielding Aspects

CERN Document Server

Y. Romanets and R. Luís (ITN)

The objective of this work was to carry out a detailed study and analysis of all aspects related toradioprotection and radiation safety of the spallation target area and the whole spaces reservedfor the fission targets and spallation target maintenance. Operational and no‐operationalconditions were considered for an evaluation of the radiation safety conditions.An analysis of the proposed shielding dimensions and configuration was performed for thesystem during operation time. Parameters as activation, dose rate, energy deposition, etc. aremore important for the no‐operation period, in order to evaluate the hazard level anddetermine the staff access type to the maintenance areas (direct or remote control).Such elements as the fission targets and the whole structure involved on it were studied in moredetail because of the disposal issues, after operation. Activation, dose rate and residual nuclideswere studied for each element of the assembly. All parameters were analyzed according to their...

Image-Based Multi-Target Tracking through Multi-Bernoulli Filtering with Interactive Likelihoods.

Science.gov (United States)

Hoak, Anthony; Medeiros, Henry; Povinelli, Richard J

2017-03-03

We develop an interactive likelihood (ILH) for sequential Monte Carlo (SMC) methods for image-based multiple target tracking applications. The purpose of the ILH is to improve tracking accuracy by reducing the need for data association. In addition, we integrate a recently developed deep neural network for pedestrian detection along with the ILH with a multi-Bernoulli filter. We evaluate the performance of the multi-Bernoulli filter with the ILH and the pedestrian detector in a number of publicly available datasets (2003 PETS INMOVE, Australian Rules Football League (AFL) and TUD-Stadtmitte) using standard, well-known multi-target tracking metrics (optimal sub-pattern assignment (OSPA) and classification of events, activities and relationships for multi-object trackers (CLEAR MOT)). In all datasets, the ILH term increases the tracking accuracy of the multi-Bernoulli filter.

Coherence Effects on the Power and Tower Loads of a 7 × 2 MW Multi-Rotor Wind Turbine System

Directory of Open Access Journals (Sweden)

Shigeo Yoshida

2016-09-01

Full Text Available A multi-rotor system (MRS, in which multiple wind turbines are placed on one tower, is a promising concept for super-large wind turbines at over 10 MW due to the cost and weight advantages. The coherence effects on an MRS were investigated in this study. Although a wide range of coherences were measured so far, a decay constant of C = 12 is recommended in the IEC61400-1 standard. Dynamic simulations were performed for a 14-MW MRS, which consists of seven 2-MW turbines and includes wind models with three different coherences. Although the results show that a larger coherence increases the output power and the collective loads due to tower base fore-aft bending, it reduces the differential loads due to tower-base torque and tower-top nodding. The most significant case is the fatigue damage due to tower base fore-aft bending, which was more than doubled between the decay constants of C = 6 and C = 12. The present results indicate that the coherence should be defined carefully in the design of large-scale MRSs because its effect on them is not straightforward.

Image-Based Multi-Target Tracking through Multi-Bernoulli Filtering with Interactive Likelihoods

Directory of Open Access Journals (Sweden)

Anthony Hoak

2017-03-01

Full Text Available We develop an interactive likelihood (ILH for sequential Monte Carlo (SMC methods for image-based multiple target tracking applications. The purpose of the ILH is to improve tracking accuracy by reducing the need for data association. In addition, we integrate a recently developed deep neural network for pedestrian detection along with the ILH with a multi-Bernoulli filter. We evaluate the performance of the multi-Bernoulli filter with the ILH and the pedestrian detector in a number of publicly available datasets (2003 PETS INMOVE, Australian Rules Football League (AFL and TUD-Stadtmitte using standard, well-known multi-target tracking metrics (optimal sub-pattern assignment (OSPA and classification of events, activities and relationships for multi-object trackers (CLEAR MOT. In all datasets, the ILH term increases the tracking accuracy of the multi-Bernoulli filter.

Innovative Waste Management in the Mercury Loop of the EURISOL Multi-MW Converter Target

CERN Document Server

PSI: Jörg Neuhausen, Dorothea Schumann, Rugard Dressler, Susanne Horn, Sabrina Lüthi, Stephan Heinitz, Suresh ChirikiCERN: Thierry Stora, Martin Eller

The choice of mercury as target material imposes various questions concerning the safe operation of such a system that are related to the physical and chemical properties of the target material itself and the nuclear reaction products produced within the target during its life time of several decades. Therefore, a subtask was created within the EURISOL-DS project that is concerned with studying an innovative waste management for the generated radioactivity by chemical means. Such a study strongly depends on the radioactive inventory and its distribution throughout the target and loop system. Radioactive inventory calculations were performed within task 5 [6]. The distribution of nuclear reaction products and their chemical state that can be expected within the target and loop system is one of the topics covered in this report. Based on the results obtained by theoretical studies as well as laboratory scale experiments, the feasibility of waste reduction using chemical methods, both conventional (e.g. leaching...

EURISOL Multi-MW Target: Investigation of the hydrodynamics of liquid metal (Hg) jet

CERN Document Server

Freibergs, J

In order to develop a windowless target it is necessary to investigate the hydrodynamics of liquid metal (Hg) jet. On the basis of the schematic layout of a high-power target module presented in Ref. [2], and the parameters of the windowless target (speed of the mercury jet up to 30 m/s, diameter of jet 10-20 mm and length of jet about 1 m), a first estimation of the parameters of the main components of a Hg-loop has been obtained by the Institute of Physics, University of Latvia. A preliminary engineering design of a functional Hg-loop to be constructed soon is also proposed. A simplified water stand has been developed with the ability of testing different Hg-nozzle configurations. The tests carried out showed that the kinetic energy of the jet is so high that the coaxial water flow at contact point is transformed into small bubbles (spray). The characteristics of the jet were shown to depend on the pressure of the stand.

EURISOL-DS Multi-MW Target: A safe way to run the CGS converter

CERN Document Server

Cyril Kharoua, Yacine Kadi, Karel Samec (CERN)

This technical note summarizes the design calculations performed within Task#2 of the European Isotope Separation On-Line Radioactive Ion Beam Facility Design Study (EURISOL-DS) on the safety hull of the CGS design of the mercury converter. A study was carried out in order to propose a configuration for the safety hull and the connection between the target and the accelerator. The results of these calculations show a layout and a design proposal for the safety barrier of the EURISOL DS target design.

Seismic analysis of fuel and target assemblies at a production reactor

International Nuclear Information System (INIS)

Braverman, J.I.; Wang, Y.K.

1991-01-01

This paper describes the unique modeling and analysis considerations used to assess the seismic adequacy of the fuel and target assemblies in a production reactor at Savannah River Site. This confirmatory analysis was necessary to provide assurance that the reactor can operate safely during a seismic event and be brought to a safe shutdown condition. The plant which was originally designed in the 1950's required to be assessed to more current seismic criteria. The design of the reactor internals and the magnitude of the structural responses enabled the use of a linear elastic dynamic analysis. A seismic analysis was performed using a finite element model consisting of the fuel and target assemblies, reactor tank, and a portion of the concrete structure supporting the reactor tank. The effects of submergence of the fuel and target assemblies in the water contained within the reactor tank can have a significant effect on their seismic response. Thus, the model included hydrodynamic fluid coupling effects between the assemblies and the reactor tank. Fluid coupling mass terms were based on formulations for solid bodies immersed in incompressible and frictionless fluids. The potential effects of gap conditions were also assessed in this evaluation. 5 refs., 6 figs., 1 tab

Multi-Source Multi-Target Dictionary Learning for Prediction of Cognitive Decline.

Science.gov (United States)

Zhang, Jie; Li, Qingyang; Caselli, Richard J; Thompson, Paul M; Ye, Jieping; Wang, Yalin

2017-06-01

Alzheimer's Disease (AD) is the most common type of dementia. Identifying correct biomarkers may determine pre-symptomatic AD subjects and enable early intervention. Recently, Multi-task sparse feature learning has been successfully applied to many computer vision and biomedical informatics researches. It aims to improve the generalization performance by exploiting the shared features among different tasks. However, most of the existing algorithms are formulated as a supervised learning scheme. Its drawback is with either insufficient feature numbers or missing label information. To address these challenges, we formulate an unsupervised framework for multi-task sparse feature learning based on a novel dictionary learning algorithm. To solve the unsupervised learning problem, we propose a two-stage Multi-Source Multi-Target Dictionary Learning (MMDL) algorithm. In stage 1, we propose a multi-source dictionary learning method to utilize the common and individual sparse features in different time slots. In stage 2, supported by a rigorous theoretical analysis, we develop a multi-task learning method to solve the missing label problem. Empirical studies on an N = 3970 longitudinal brain image data set, which involves 2 sources and 5 targets, demonstrate the improved prediction accuracy and speed efficiency of MMDL in comparison with other state-of-the-art algorithms.

1.5 MW RF Load for ITER

International Nuclear Information System (INIS)

Ives, Robert Lawrence; Marsden, David; Collins, George; Karimov, Rasul; Mizuhara, Max; Neilson, Jeffrey

2016-01-01

Calabazas Creek Research, Inc. developed a 1.5 MW RF load for the ITER fusion research facility currently under construction in France. This program leveraged technology developed in two previous SBIR programs that successfully developed high power RF loads for fusion research applications. This program specifically focused on modifications required by revised technical performance, materials, and assembly specification for ITER. This program implemented an innovative approach to actively distribute the RF power inside the load to avoid excessive heating or arcing associated with constructive interference. The new design implemented materials and assembly changes required to meet specifications. Critical components were built and successfully tested during the program.

1.5 MW RF Load for ITER

Energy Technology Data Exchange (ETDEWEB)

Ives, Robert Lawrence [Calabazas Creek Research, Inc., San Mateo, CA (United States); Marsden, David [Calabazas Creek Research, Inc., San Mateo, CA (United States); Collins, George [Calabazas Creek Research, Inc., San Mateo, CA (United States); Karimov, Rasul [Calabazas Creek Research, Inc., San Mateo, CA (United States); Mizuhara, Max [Calabazas Creek Research, Inc., San Mateo, CA (United States); Neilson, Jeffrey [Lexam Research, Redwood City, CA (United States)

2016-09-01

Calabazas Creek Research, Inc. developed a 1.5 MW RF load for the ITER fusion research facility currently under construction in France. This program leveraged technology developed in two previous SBIR programs that successfully developed high power RF loads for fusion research applications. This program specifically focused on modifications required by revised technical performance, materials, and assembly specification for ITER. This program implemented an innovative approach to actively distribute the RF power inside the load to avoid excessive heating or arcing associated with constructive interference. The new design implemented materials and assembly changes required to meet specifications. Critical components were built and successfully tested during the program.

Project and characteristics of a 5MW experimental fast reactor

International Nuclear Information System (INIS)

Ishiguro, Y.; Nascimento, J.A. do.

1986-05-01

Characteristics of a 5 MW experimental fast reactor are reported. The reactor is designed with emphasis on fuel and materials irradiation and uses fuel assemblies of a standard structure. The reference core consist of 37 fuel assemblies, each of which contains 19 pins of metallic Pu/Zr fuel. With a core height of 17.6 cm the core volume is 11.4 liter and the central fast (E >=100 KeV) flux is 0.9 x 10 15 n/cm 2 sec. In addition to twelve control rod assemblies with a total reactivity worth of 5.5% Δk, 42 assemblies for reactivity compensation are placed in the two rings outside the core. Replacing these assemblies with driver, blanket, or refletor-shield assemblies, large reactivities can be added to make the central assembly position available for test irradiations and to assure high levels of burnup of driver assemblies. (Author) [pt

Neutronic performance of a benchmark 1-MW LPSS

International Nuclear Information System (INIS)

Russell, G.J.; Pitcher, E.J.; Ferguson, P.D.

1995-01-01

We used split-target/flux-trap-moderator geometry in our 1-MW LPSS computational benchmark performance calculations because the simulation models were readily available. Also, this target/moderator arrangement is a proven LANSCE design and a good neutronic performer. The model has four moderator viewed surfaces, each with a 13x13 cm field-of-view. For our scoping neutronic-performance calculations, we attempted to get as much engineering realism into the target-system mockup as possible. In our present model, we account for target/reflector dilution by cooling; the D 2 O coolant fractions are adequate for 1 MW of 800-MeV protons (1.25 mA). We have incorporated a proton beam entry window and target canisters into the model, as well as (partial) moderator and vacuum canisters. The model does not account for target and moderator cooling lines and baffles, entire moderator canisters, and structural material in the reflector

Designing multi-targeted agents: An emerging anticancer drug discovery paradigm.

Science.gov (United States)

Fu, Rong-Geng; Sun, Yuan; Sheng, Wen-Bing; Liao, Duan-Fang

2017-08-18

The dominant paradigm in drug discovery is to design ligands with maximum selectivity to act on individual drug targets. With the target-based approach, many new chemical entities have been discovered, developed, and further approved as drugs. However, there are a large number of complex diseases such as cancer that cannot be effectively treated or cured only with one medicine to modulate the biological function of a single target. As simultaneous intervention of two (or multiple) cancer progression relevant targets has shown improved therapeutic efficacy, the innovation of multi-targeted drugs has become a promising and prevailing research topic and numerous multi-targeted anticancer agents are currently at various developmental stages. However, most multi-pharmacophore scaffolds are usually discovered by serendipity or screening, while rational design by combining existing pharmacophore scaffolds remains an enormous challenge. In this review, four types of multi-pharmacophore modes are discussed, and the examples from literature will be used to introduce attractive lead compounds with the capability of simultaneously interfering with different enzyme or signaling pathway of cancer progression, which will reveal the trends and insights to help the design of the next generation multi-targeted anticancer agents. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Changing paradigm from one target one ligand towards multi target directed ligand design for key drug targets of Alzheimer disease: An important role of Insilco methods in multi target directed ligands design.

Science.gov (United States)

Kumar, Akhil; Tiwari, Ashish; Sharma, Ashok

2018-03-15

Alzheimer disease (AD) is now considered as a multifactorial neurodegenerative disorder and rapidly increasing to an alarming situation and causing higher death rate. One target one ligand hypothesis is not able to provide complete solution of AD due to multifactorial nature of disease and one target one drug seems to fail to provide better treatment against AD. Moreover, current available treatments are limited and most of the upcoming treatments under clinical trials are based on modulating single target. So the current AD drug discovery research shifting towards new approach for better solution that simultaneously modulate more than one targets in the neurodegenerative cascade. This can be achieved by network pharmacology, multi-modal therapies, multifaceted, and/or the more recently proposed term "multi-targeted designed drugs. Drug discovery project is tedious, costly and long term project. Moreover, multi target AD drug discovery added extra challenges such as good binding affinity of ligands for multiple targets, optimal ADME/T properties, no/less off target side effect and crossing of the blood brain barrier. These hurdles may be addressed by insilico methods for efficient solution in less time and cost as computational methods successfully applied to single target drug discovery project. Here we are summarizing some of the most prominent and computationally explored single target against AD and further we discussed successful example of dual or multiple inhibitors for same targets. Moreover we focused on ligand and structure based computational approach to design MTDL against AD. However is not an easy task to balance dual activity in a single molecule but computational approach such as virtual screening docking, QSAR, simulation and free energy are useful in future MTDLs drug discovery alone or in combination with fragment based method. However, rational and logical implementations of computational drug designing methods are capable of assisting AD drug

Combined scanning probe and light scattering characterization of multi-stage self-assembly of targeted liposome-based delivery systems

International Nuclear Information System (INIS)

Farkas, N; Dagata, J A; Yang, C; Rait, A; Pirollo, K F; Chang, E H

2011-01-01

The mean size and size distribution of a targeted nanoparticle delivery system (NDS) strongly influences the intrinsic stability and functionality of this molecular complex, affects its performance as a systemic drug delivery platform and ultimately determines its efficacy toward early detection and treatment of cancer. Since its components undergo significant reorganization during multiple stages of self-assembly, it is essential to monitor the size and stability of the complex throughout the NDS formulation in order to ensure its potency and manufacturability prior to entering clinical trials. This work combines scanning probe microscopy (SPM) and dynamic light scattering (DLS) techniques to obtain quantitative and reliable size measurements of the NDS, and to investigate how variations in the NDS formulation or self-assembly process impact the size, structure and functionality of the complex with various therapeutic and diagnostic agent payloads. These combined SPM and DLS methods, when implemented at an early stage of the NDS formulation, present a potential measurement approach to facilitate drug discovery and development, optimization and quality control during manufacturing of the NDS

Hybrid Wing Body Multi-Bay Test Article Analysis and Assembly Final Report

Science.gov (United States)

Velicki, Alexander; Hoffman, Krishna; Linton, Kim A.; Baraja, Jaime; Wu, Hsi-Yung T.; Thrash, Patrick

2017-01-01

This report summarizes work performed by The Boeing Company, through its Boeing Research & Technology organization located in Huntington Beach, California, under the Environmentally Responsible Aviation (ERA) project. The report documents work performed to structurally analyze and assemble a large-scale Multi-bay Box (MBB) Test Article capable of withstanding bending and internal pressure loadings representative of a Hybrid Wing Body (HWB) aircraft. The work included fabrication of tooling elements for use in the fabrication and assembly of the test article.

Directed self-assembly of large scaffold-free multi-cellular honeycomb structures

International Nuclear Information System (INIS)

Tejavibulya, Nalin; Youssef, Jacquelyn; Bao, Brian; Ferruccio, Toni-Marie; Morgan, Jeffrey R

2011-01-01

A significant challenge to the field of biofabrication is the rapid construction of large three-dimensional (3D) living tissues and organs. Multi-cellular spheroids have been used as building blocks. In this paper, we create large multi-cellular honeycomb building blocks using directed self-assembly, whereby cell-to-cell adhesion, in the context of the shape and obstacles of a micro-mold, drives the formation of a 3D structure. Computer-aided design, rapid prototyping and replica molding were used to fabricate honeycomb-shaped micro-molds. Nonadhesive hydrogels cast from these micro-molds were equilibrated in the cell culture medium and seeded with two types of mammalian cells. The cells settled into the honeycomb recess were unable to attach to the nonadhesive hydrogel and so cell-to-cell adhesion drove the self-assembly of a large multi-cellular honeycomb within 24 h. Distinct morphological changes occurred to the honeycomb and its cells indicating the presence of significant cell-mediated tension. Unlike the spheroid, whose size is constrained by a critical diffusion distance needed to maintain cell viability, the overall size of the honeycomb is not limited. The rapid production of the honeycomb building unit, with its multiple rings of high-density cells and open lumen spaces, offers interesting new possibilities for biofabrication strategies.

Multi-protein assemblies underlie the mesoscale organization of the plasma membrane

Science.gov (United States)

Saka, Sinem K.; Honigmann, Alf; Eggeling, Christian; Hell, Stefan W.; Lang, Thorsten; Rizzoli, Silvio O.

2014-01-01

Most proteins have uneven distributions in the plasma membrane. Broadly speaking, this may be caused by mechanisms specific to each protein, or may be a consequence of a general pattern that affects the distribution of all membrane proteins. The latter hypothesis has been difficult to test in the past. Here, we introduce several approaches based on click chemistry, through which we study the distribution of membrane proteins in living cells, as well as in membrane sheets. We found that the plasma membrane proteins form multi-protein assemblies that are long lived (minutes), and in which protein diffusion is restricted. The formation of the assemblies is dependent on cholesterol. They are separated and anchored by the actin cytoskeleton. Specific proteins are preferentially located in different regions of the assemblies, from their cores to their edges. We conclude that the assemblies constitute a basic mesoscale feature of the membrane, which affects the patterning of most membrane proteins, and possibly also their activity. PMID:25060237

Multi-objective Analysis for a Sequencing Planning of Mixed-model Assembly Line

Science.gov (United States)

Shimizu, Yoshiaki; Waki, Toshiya; Yoo, Jae Kyu

Diversified customer demands are raising importance of just-in-time and agile manufacturing much more than before. Accordingly, introduction of mixed-model assembly lines becomes popular to realize the small-lot-multi-kinds production. Since it produces various kinds on the same assembly line, a rational management is of special importance. With this point of view, this study focuses on a sequencing problem of mixed-model assembly line including a paint line as its preceding process. By taking into account the paint line together, reducing work-in-process (WIP) inventory between these heterogeneous lines becomes a major concern of the sequencing problem besides improving production efficiency. Finally, we have formulated the sequencing problem as a bi-objective optimization problem to prevent various line stoppages, and to reduce the volume of WIP inventory simultaneously. Then we have proposed a practical method for the multi-objective analysis. For this purpose, we applied the weighting method to derive the Pareto front. Actually, the resulting problem is solved by a meta-heuristic method like SA (Simulated Annealing). Through numerical experiments, we verified the validity of the proposed approach, and discussed the significance of trade-off analysis between the conflicting objectives.

Conceptual Nuclear Design of a 20 MW Multipurpose Research Reactor

Energy Technology Data Exchange (ETDEWEB)

Seo, Chul Gyo; Kim, Hak Sung; Park, Cheol [KAERI, Daejeon (Korea, Republic of); Nghiem, Huynh Ton; Vinh, Le Vinh; Dang, Vo Doan Hai [Dalat Nuclear Research Reactor, Hanoi (Viet Nam)

2007-08-15

A conceptual nuclear design of a 20 MW multi-purpose research reactor for Vietnam has been jointly done by the KAERI and the DNRI (VAEC). The AHR reference core in this report is a right water cooled and a heavy water reflected open-tank-in-pool type multipurpose research reactor with 20 MW. The rod type fuel of a dispersed U{sub 3}Si{sub 2}-Al with a density of 4.0 gU/cc is used as a fuel. The core consists of fourteen 36-element assemblies, four 18-element assemblies and has three in-core irradiation sites. The reflector tank filled with heavy water surrounds the core and provides rooms for various irradiation holes. Major analyses have been done for the relevant nuclear design parameters such as the neutron flux and power distributions, reactivity coefficients, control rod worths, etc. For the analysis, the MCNP, MVP, and HELIOS codes were used by KAERI and DNRI (VAEC). The results by MCNP (KAERI) and MVP (DNRI) showed good agreements and can be summarized as followings. For a clean, unperturbed core condition such that the fuels are all fresh and there are no irradiation holes in the reflector region, the fast neutron flux (E{sub n}{>=}1.0 MeV) reaches 1.47x10{sup 14} n/cm{sup 2}s and the maximum thermal neutron flux (E{sub n}{<=}0.625 eV) reaches 4.43x10{sup 14} n/cm{sup 2}s in the core region. In the reflector region, the thermal neutron peak occurs about 28 cm far from the core center and the maximum thermal neutron flux is estimated to be 4.09x10{sup 14} n/cm{sup 2}s. For the analysis of the equilibrium cycle core, the irradiation facilities in the reflector region were considered. The cycle length was estimated as 38 days long with a refueling scheme of replacing three 36-element fuel assemblies or replacing two 36-element and one 18-element fuel assemblies. The excess reactivity at a BOC was 103.4 mk, and 24.6 mk at a minimum was reserved at an EOC. The assembly average discharge burnup was 54.6% of initial U-235 loading. For the proposed fuel management

Aero-Elastic Optimization of a 10 MW Wind Turbine

DEFF Research Database (Denmark)

Zahle, Frederik; Tibaldi, Carlo; Verelst, David Robert

2015-01-01

This article describes a multi-disciplinary optimization and analysis tool for wind turbines that is based on the open-source framework OpenMDAO. Interfaces to several simulation codes have been implemented which allows for a wide variety of problem formulations and combinations of models....... In this article concurrent aeroelastic optimization of a 10 MW wind turbine rotor is carried out with respect to material distribution distribution and planform. The optimizations achieve up to 13% mass reduction while maintaining the same power production compared to the baseline DTU 10MW RWT....

Automated simultaneous assembly of multi-stage testing for the uniform CPA examination

NARCIS (Netherlands)

Breithaupt, Krista; Ariel, A.; Veldkamp, Bernard P.

2004-01-01

Some solutions used in the assembly of the computerized Uniform Certified Public Accountancy (CPA) licensing examination are offered as practical alternatives for operational programs producing large numbers of forms. The Uniform CPA examination will be offered as an adaptive multi-stage test (MST)

Multi-MW Spallation Neutron Sources: Current Challenges and Future Prospects, 16th, 17th and 18th March 2009 in Bilbao (Spain)

International Nuclear Information System (INIS)

2009-01-01

The strategy of building a multi MW, accelerator based spallation neutron source as the next generation neutron facility for Europe has been validated by the successful commissioning and operation of the SNS in the US (now operating close to 1 MW beam power) and the JPARC facility in Japan. However, since the original baseline design of ESS was completed in 2002, the underlying technology has advanced and some considerable experience has been gathered from these new facilities. Hence as Europe prepares for the construction of ESS, the time is ripe to learn from ongoing experience and define the development areas which would allow the ESS to take the most advantage from recent advances in technology while maintaining a reliable, low risk, design. The goal of the workshop, organized by the ESS Bilbao consortium, was to assess the current challenges facing multi-MW spallation sources and, taking into account synergies with other international projects of a similar nature, outline a road map for a collaborative Research and Development program that would enable Europe to meet these challenges for the timely construction of ESS. The full reports and recommendations from the various working groups are provided in the following pages. They lay the foundation for a road map for a collaborative development program which will enable the ESS to take full advantage of the relevant expertise which is distributed across various facilities and countries within Europe to produce a truly European facility at the forefront of the technology. This report is a witness to the willingness of a great many people to share their experiences and knowledge in an open and cooperative environment. (Author)

Tyrosine kinase inhibitors: Multi-targeted or single-targeted?

Science.gov (United States)

Broekman, Fleur; Giovannetti, Elisa; Peters, Godefridus J

2011-02-10

Since in most tumors multiple signaling pathways are involved, many of the inhibitors in clinical development are designed to affect a wide range of targeted kinases. The most important tyrosine kinase families in the development of tyrosine kinase inhibitors are the ABL, SCR, platelet derived growth factor, vascular endothelial growth factor receptor and epidermal growth factor receptor families. Both multi-kinase inhibitors and single-kinase inhibitors have advantages and disadvantages, which are related to potential resistance mechanisms, pharmacokinetics, selectivity and tumor environment. In different malignancies various tyrosine kinases are mutated or overexpressed and several resistance mechanisms exist. Pharmacokinetics is influenced by interindividual differences and differs for two single targeted inhibitors or between patients treated by the same tyrosine kinase inhibitor. Different tyrosine kinase inhibitors have various mechanisms to achieve selectivity, while differences in gene expression exist between tumor and stromal cells. Considering these aspects, one type of inhibitor can generally not be preferred above the other, but will depend on the specific genetic constitution of the patient and the tumor, allowing personalized therapy. The most effective way of cancer treatment by using tyrosine kinase inhibitors is to consider each patient/tumor individually and to determine the strategy that specifically targets the consequences of altered (epi)genetics of the tumor. This strategy might result in treatment by a single multi kinase inhibitor for one patient, but in treatment by a couple of single kinase inhibitors for other patients.

An investigative approach to explore optimum assembly process design for annular targets carrying LEU foil

Science.gov (United States)

Hoyer, Annemarie

Technetium-99m is the most widely used nuclear isotope in the medical field, with nearly 80 to 85% of all diagnostic imaging procedures. The daughter isotope of molybdenum-99 is currently produced using weapons-grade uranium. A suggested design for aluminum targets carrying low-enriched uranium (LEU) foil is presented for the fulfillment of eliminating highly enriched uranium (HEU) for medical isotope production. The assembly process that this research focuses on is the conventional draw-plug process which is currently used and lastly the sealing process. The research is unique in that it is a systematic approach to explore the optimal target assembly process to produce those targets with the required quality and integrity. Conducting 9 parametric experiments, aluminum tubes with a nickel foil fission-barrier and a surrogate stainless steel foil are assembled, welded and then examined to find defects, to determine residual stresses, and to find the best cost-effective target dimensions. The experimental design consists of 9 assembly combinations that were found through orthogonal arrays in order to explore the significance of each factor. Using probabilistic modeling, the parametric study is investigated using the Taguchi method of robust analysis. Depending on the situation, optimal conditions may be a nominal, a minimized or occasionally a maximized condition. The results will provide the best target design and will give optimal quality with little or no assembly defects.

Assembler absolute forward thick-target bremsstrahlung spectra program

International Nuclear Information System (INIS)

Niculescu, V.I.R.; Baciu, G.; Ionescu-Bujor, M.

1981-12-01

The program is intended to compute the absolute forward thick-target bremsstrahlung spectrum for electrons in the energy range 1-24 MeV. The program takes into account the following phenomena: multiple scattering, energy loss and the attenuation of the emitted gamma rays. The computer program is written in Assembler having a higher degree of generality and is more performant than the FORTRAN version. (authors)

A PZT Actuated Triple-Finger Gripper for Multi-Target Micromanipulation

Directory of Open Access Journals (Sweden)

Tao Chen

2017-01-01

Full Text Available This paper presents a triple-finger gripper driven by a piezoceramic (PZT transducer for multi-target micromanipulation. The gripper consists of three fingers assembled on adjustable pedestals with flexible hinges for a large adjustable range. Each finger has a PZT actuator, an amplifying structure, and a changeable end effector. The moving trajectories of single and double fingers were calculated and finite element analyses were performed to verify the reliability of the structures. In the gripping experiment, various end effectors of the fingers such as tungsten probes and fibers were tested, and different micro-objects such as glass hollow spheres and iron spheres with diameters ranging from 10 to 800 μm were picked and released. The output resolution is 145 nm/V, and the driven displacement range of the gripper is 43.4 μm. The PZT actuated triple-finger gripper has superior adaptability, high efficiency, and a low cost.

The Winfrith 9MW heat transfer rig

International Nuclear Information System (INIS)

Obertelli, J.D.

1976-01-01

The Winfrith 9MW Rig is used for studying heat transfer and flow resistance in a variety of test sections at system pressures up to 68 bar. The basic rig and its instrumentation are discussed together with the characteristics of the test section design. The rig has been used in studies involving the full scale simulation of Steam Generating Heavy Water (SGHW) fuel assemblies and the paper discusses the measurements made in this type of study. (author)

The development and testing of the thermal break divertor monoblock target design delivering 20 MW m-2 heat load capability

Science.gov (United States)

Fursdon, M.; Barrett, T.; Domptail, F.; Evans, Ll M.; Luzginova, N.; Greuner, N. H.; You, J.-H.; Li, M.; Richou, M.; Gallay, F.; Visca, E.

2017-12-01

The design and development of a novel plasma facing component (for fusion power plants) is described. The component uses the existing ‘monoblock’ construction which consists of a tungsten ‘block’ joined via a copper interlayer to a through CuCrZr cooling pipe. In the new concept the interlayer stiffness and conductivity properties are tuned so that stress in the principal structural element of the component (the cooling pipe) is reduced. Following initial trials with off-the-shelf materials, the concept was realized by machined features in an otherwise solid copper interlayer. The shape and distribution of the features were tuned by finite element analyses subject to ITER structural design criterion in-vessel components (SDC-IC) design rules. Proof of concept mock-ups were manufactured using a two stage brazing process verified by tomography and micrographic inspection. Full assemblies were inspected using ultrasound and thermographic (SATIR) test methods at ENEA and CEA respectively. High heat flux tests using IPP’s GLADIS facility showed that 200 cycles at 20 MW m-2 and five cycles at 25 MW m-2 could be sustained without apparent component damage. Further testing and component development is planned.

The development and testing of the thermal break divertor monoblock target design delivering 20 MW m−2 heat load capability

International Nuclear Information System (INIS)

Fursdon, M; Barrett, T; Domptail, F; Evans, Ll M; Luzginova, N; Greuner, N H; You, J-H; Li, M; Richou, M; Gallay, F; Visca, E

2017-01-01

The design and development of a novel plasma facing component (for fusion power plants) is described. The component uses the existing ‘monoblock’ construction which consists of a tungsten ‘block’ joined via a copper interlayer to a through CuCrZr cooling pipe. In the new concept the interlayer stiffness and conductivity properties are tuned so that stress in the principal structural element of the component (the cooling pipe) is reduced. Following initial trials with off-the-shelf materials, the concept was realized by machined features in an otherwise solid copper interlayer. The shape and distribution of the features were tuned by finite element analyses subject to ITER structural design criterion in-vessel components (SDC-IC) design rules. Proof of concept mock-ups were manufactured using a two stage brazing process verified by tomography and micrographic inspection. Full assemblies were inspected using ultrasound and thermographic (SATIR) test methods at ENEA and CEA respectively. High heat flux tests using IPP’s GLADIS facility showed that 200 cycles at 20 MW m −2 and five cycles at 25 MW m −2 could be sustained without apparent component damage. Further testing and component development is planned. (paper)

Evaluation of residual radioactivity and dose rate of a target assembly in an IBA cyclotron

Energy Technology Data Exchange (ETDEWEB)

Hwang, Seon Yong; Kim, Young Ju; Lee, Seung Wook [School of Mechanical Engineering, Pusan National University (Korea, Republic of)

2016-12-15

When a cyclotron produces 18F-, accelerated protons interact with metal parts of the cyclotron machine and induces radioactivity. Especially, the target window and chamber of the target assembly are the main parts where long-lived radionuclides are generated as they are incident by direct beams. It is of great importance to identify radionuclides induced in the target assembly for the safe operation and maintenance of a cyclotron facility. In this study, we analyzed major radionuclides generated in the target assembly by an operation of the Cyclotron 18/9 machine and measured dose rates after the operation to establish the radiation safety guideline for operators and maintenance personnel of the machine. Gamma spectroscopy with HPGe was performed on samples from the target chamber and Havar foil target window to identify the radionuclides generated during the operation for production of 18F-- isotope and their specific activity. Also, the dose rates from the target were measured as a function of time after an operation. These data will help improve radiological safety of operating the cyclotron facilities.

Multi-target-qubit unconventional geometric phase gate in a multi-cavity system.

Science.gov (United States)

Liu, Tong; Cao, Xiao-Zhi; Su, Qi-Ping; Xiong, Shao-Jie; Yang, Chui-Ping

2016-02-22

Cavity-based large scale quantum information processing (QIP) may involve multiple cavities and require performing various quantum logic operations on qubits distributed in different cavities. Geometric-phase-based quantum computing has drawn much attention recently, which offers advantages against inaccuracies and local fluctuations. In addition, multiqubit gates are particularly appealing and play important roles in QIP. We here present a simple and efficient scheme for realizing a multi-target-qubit unconventional geometric phase gate in a multi-cavity system. This multiqubit phase gate has a common control qubit but different target qubits distributed in different cavities, which can be achieved using a single-step operation. The gate operation time is independent of the number of qubits and only two levels for each qubit are needed. This multiqubit gate is generic, e.g., by performing single-qubit operations, it can be converted into two types of significant multi-target-qubit phase gates useful in QIP. The proposal is quite general, which can be used to accomplish the same task for a general type of qubits such as atoms, NV centers, quantum dots, and superconducting qubits.

Assembling the Streptococcus thermophilus clustered regularly interspaced short palindromic repeats (CRISPR) array for multiplex DNA targeting.

Science.gov (United States)

Guo, Lijun; Xu, Kun; Liu, Zhiyuan; Zhang, Cunfang; Xin, Ying; Zhang, Zhiying

2015-06-01

In addition to the advantages of scalable, affordable, and easy to engineer, the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) technology is superior for multiplex targeting, which is laborious and inconvenient when achieved by cloning multiple gRNA expressing cassettes. Here, we report a simple CRISPR array assembling method which will facilitate multiplex targeting usage. First, the Streptococcus thermophilus CRISPR3/Cas locus was cloned. Second, different CRISPR arrays were assembled with different crRNA spacers. Transformation assays using different Escherichia coli strains demonstrated efficient plasmid DNA targeting, and we achieved targeting efficiency up to 95% with an assembled CRISPR array with three crRNA spacers. Copyright © 2015 Elsevier Inc. All rights reserved.

Multi-targeted priming for genome-wide gene expression assays

Directory of Open Access Journals (Sweden)

Adomas Aleksandra B

2010-08-01

Full Text Available Abstract Background Complementary approaches to assaying global gene expression are needed to assess gene expression in regions that are poorly assayed by current methodologies. A key component of nearly all gene expression assays is the reverse transcription of transcribed sequences that has traditionally been performed by priming the poly-A tails on many of the transcribed genes in eukaryotes with oligo-dT, or by priming RNA indiscriminately with random hexamers. We designed an algorithm to find common sequence motifs that were present within most protein-coding genes of Saccharomyces cerevisiae and of Neurospora crassa, but that were not present within their ribosomal RNA or transfer RNA genes. We then experimentally tested whether degenerately priming these motifs with multi-targeted primers improved the accuracy and completeness of transcriptomic assays. Results We discovered two multi-targeted primers that would prime a preponderance of genes in the genomes of Saccharomyces cerevisiae and Neurospora crassa while avoiding priming ribosomal RNA or transfer RNA. Examining the response of Saccharomyces cerevisiae to nitrogen deficiency and profiling Neurospora crassa early sexual development, we demonstrated that using multi-targeted primers in reverse transcription led to superior performance of microarray profiling and next-generation RNA tag sequencing. Priming with multi-targeted primers in addition to oligo-dT resulted in higher sensitivity, a larger number of well-measured genes and greater power to detect differences in gene expression. Conclusions Our results provide the most complete and detailed expression profiles of the yeast nitrogen starvation response and N. crassa early sexual development to date. Furthermore, our multi-targeting priming methodology for genome-wide gene expression assays provides selective targeting of multiple sequences and counter-selection against undesirable sequences, facilitating a more complete and

EURISOL-DS Multi-MW Target: Thermal Behaviour of the fission target disk arrangement inspired by the MAFF project

CERN Document Server

Cyril Kharoua, Yacine Kadi and the EURISOL-DS Task#2 collaboration

This technical note summarises the design calculations performed within Task #2 of the European Isotope Separation On-Line Radioactive Ion Beam Facility Design Study (EURISOL-DS) [1] for the thermal behaviour of the fission target.A preliminary study was carried out in order to determine the heat deposition within the fissile material and estimate the temperature rise. This new solution takes into account the problems related to effusion/diffusion of radioactive isotopes inside a thick target. To enhance the extraction rates and the thermal behaviour it is proposed to study a solution where the fissile material is split into an arrangement of disks.

Self-Assembly of Multi-nanozymes to Mimic an Intracellular Antioxidant Defense System.

Science.gov (United States)

Huang, Yanyan; Liu, Zhen; Liu, Chaoqun; Ju, Enguo; Zhang, Yan; Ren, Jinsong; Qu, Xiaogang

2016-06-01

In this work, for the first time, we constructed a novel multi-nanozymes cooperative platform to mimic intracellular antioxidant enzyme-based defense system. V2 O5 nanowire served as a glutathione peroxidase (GPx) mimic while MnO2 nanoparticle was used to mimic superoxide dismutase (SOD) and catalase (CAT). Dopamine was used as a linker to achieve the assembling of the nanomaterials. The obtained V2 O5 @pDA@MnO2 nanocomposite could serve as one multi-nanozyme model to mimic intracellular antioxidant enzyme-based defense procedure in which, for example SOD, CAT, and GPx co-participate. In addition, through assembling with dopamine, the hybrid nanocomposites provided synergistic antioxidative effect. Importantly, both in vitro and in vivo experiments demonstrated that our biocompatible system exhibited excellent intracellular reactive oxygen species (ROS) removal ability to protect cell components against oxidative stress, showing its potential application in inflammation therapy. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Fusion-based multi-target tracking and localization for intelligent surveillance systems

Science.gov (United States)

Rababaah, Haroun; Shirkhodaie, Amir

2008-04-01

In this paper, we have presented two approaches addressing visual target tracking and localization in complex urban environment. The two techniques presented in this paper are: fusion-based multi-target visual tracking, and multi-target localization via camera calibration. For multi-target tracking, the data fusion concepts of hypothesis generation/evaluation/selection, target-to-target registration, and association are employed. An association matrix is implemented using RGB histograms for associated tracking of multi-targets of interests. Motion segmentation of targets of interest (TOI) from the background was achieved by a Gaussian Mixture Model. Foreground segmentation, on other hand, was achieved by the Connected Components Analysis (CCA) technique. The tracking of individual targets was estimated by fusing two sources of information, the centroid with the spatial gating, and the RGB histogram association matrix. The localization problem is addressed through an effective camera calibration technique using edge modeling for grid mapping (EMGM). A two-stage image pixel to world coordinates mapping technique is introduced that performs coarse and fine location estimation of moving TOIs. In coarse estimation, an approximate neighborhood of the target position is estimated based on nearest 4-neighbor method, and in fine estimation, we use Euclidean interpolation to localize the position within the estimated four neighbors. Both techniques were tested and shown reliable results for tracking and localization of Targets of interests in complex urban environment.

Study of the thermo-mechanical performances of the IFMIF-EVEDA Lithium Test Loop target assembly

Energy Technology Data Exchange (ETDEWEB)

Di Maio, P.A., E-mail: dimaio@din.unipa.it [Dipartimento dell' Energia, Universita di Palermo, Viale delle Scienze, 90128 Palermo (Italy); Arena, P.; Bongiovi, G. [Dipartimento dell' Energia, Universita di Palermo, Viale delle Scienze, 90128 Palermo (Italy); Giammusso, R.; Micciche, G.; Tincani, A. [ENEA C. R. Brasimone, 40032 Camugnano, Bologna (Italy)

2012-08-15

Highlights: Black-Right-Pointing-Pointer IFMIF-EVEDA target assembly thermo-mechanical behavior has been investigated. Black-Right-Pointing-Pointer Finite element method has been followed and a commercial code has been used. Black-Right-Pointing-Pointer Nominal, design and pressure test steady state scenarios and start-up transient conditions have been investigated. Black-Right-Pointing-Pointer Steady state results have shown that back-plate yielding may occur only under the design scenario. Black-Right-Pointing-Pointer Transient analysis has indicated that TA start-up lasts for {approx}60 h. - Abstract: Within the framework of the IFMIF R and D program and in close cooperation with ENEA-Brasimone, at the Department of Energy of the University of Palermo a research campaign has been launched to investigate the thermo-mechanical behavior of the target assembly under both steady state and start-up transient conditions. A theoretical approach based on the finite element method (FEM) has been followed and a well-known commercial code has been adopted. A realistic 3D FEM model of the target assembly has been set-up and optimized by running a mesh independency analysis. A proper set of loads and boundary conditions, mainly concerned with radiation heat transfer between the target assembly external walls and the inner walls of its containment vessel, have been considered and the target assembly thermo-mechanical behavior under nominal, design and pressure test steady state scenarios and start-up transient conditions has been investigated. Results are herewith reported and discussed.

A multi attribute decision making method for selection of optimal assembly line

Directory of Open Access Journals (Sweden)

B. Vijaya Ramnath

2011-01-01

Full Text Available With globalization, sweeping technological development, and increasing competition, customers are placing greater demands on manufacturers to increase quality, flexibility, on time delivery of product and less cost. Therefore, manufacturers must develop and maintain a high degree of coherence among competitive priorities, order winning criteria and improvement activities. Thus, the production managers are making an attempt to transform their organization by adopting familiar and beneficial management philosophies like cellular manufacturing (CM, lean manufacturing (LM, green manufacturing (GM, total quality management (TQM, agile manufacturing (AM, and just in time manufacturing (JIT. The main objective of this paper is to propose an optimal assembly method for an engine manufacturer’s assembly line in India. Currently, the Indian manufacturer is following traditional assembly method where the raw materials for assembly are kept along the sideways of conveyor line. It consumes more floor space, more work in process inventory, more operator's walking time and more operator's walking distance per day. In order to reduce the above mentioned wastes, lean kitting assembly is suggested by some managers. Another group of managers suggest JIT assembly as it consumes very less inventory cost compared to other types of assembly processes. Hence, a Multi-attribute decision making model namely analytical hierarchy process (AHP is applied to analyse the alternative assembly methods based on various important factors.

EURISOL-DS Multi-MW Target Preliminary Study of the Liquid Metal Proton-to-Neutron Converter

CERN Document Server

Herrera-Martínez, A; CERN. Geneva. AB Department

2006-01-01

This technical note summarises the design calculations performed within Task #2 of the European Isotope Separation On-Line Radioactive Ion Beam Facility Design Study (EURISOL-DS) [1]. A preliminary study was carried out in order to determine the optimum value of relevant parameters in the target design. Different scenarios were simulated using the Monte Carlo code FLUKA [2]. Namely, sensitivity studies were performed to assess the impact of the projectile particle energy on the neutronics and energy deposition in the spallation target. The optimal target dimensions were also studied for every case as well as the proper target material for the liquid metal proton-to-neutron converter, since mercury and lead-bismuth eutectic are reasonable options. The effect of the beam width on the power densities was also evaluated, taking into account the geometrical limitations of the facility. Finally, a comparison between protons and deuterons as primary particles was performed, acknowledging the limitations of using FLU...

A design concept of target-moderator-reflector assemblies for KENS-II

International Nuclear Information System (INIS)

Watanabe, N.

1991-01-01

A design concept of KENS-II target-moderator-reflector assemblies is described. One of the assemblies is dedicated to the cold neutron source, and the other, to the thermal and epithermal neutron source. A flux-trap type moderator-configuration was adopted with a vertical proton-beam injection scheme. All moderators for the cold neutron source are coupled liquid hydrogen moderators with premoderators. A new scheme of proton beam delivery is proposed. The new system can provide several times higher total performance than a reference system based on a traditional single assembly with all decoupled moderators in a wing geometry and with a horizontal proton-beam injection scheme. (author)

Manufacturing and testing of a prototypical divertor vertical target for ITER

Science.gov (United States)

Merola, M.; Plöchl, L.; Chappuis, Ph; Escourbiac, F.; Grattarola, M.; Smid, I.; Tivey, R.; Vieider, G.

2000-12-01

After an extensive R&D activity, a medium-scale divertor vertical target prototype has been manufactured by the EU Home Team. This component contains all the main features of the corresponding ITER divertor design and consists of two units with one cooling channel each, assembled together and having an overall length and width of about 600 and 50 mm, respectively. The upper part of the prototype has a tungsten macro-brush armour, whereas the lower part is covered by CFC monoblocks. A number of joining techniques were required to manufacture this component as well as an appreciable effort in the development of suitable non-destructive testing methods. The component was high heat flux tested in FE200 electron beam facility at Le Creusot, France. It endured 100 cycles at 5 MW/m 2, 1000 cycles at 10 MW/m 2 and more then 1000 cycles at 15-20 MW/m 2. The final critical heat flux test reached a value in excess of 30 MW/m 2.

EURISOL-DS Multi-MW Target: Risk Register

CERN Document Server

C. Kharoua and Y. Kadi (CERN)

The purpose of the risk register is to identify and rank the risk inherent to the installation, operation, maintenance, dismantling and disposal of each item of the facility and to propose ways of mitigating such risks.It is an important input for the safety report which will be mandatory for the study towards the construction of the EURISOL Facility.

Strong underwater adhesives made by self-assembling multi-protein nanofibres.

Science.gov (United States)

Zhong, Chao; Gurry, Thomas; Cheng, Allen A; Downey, Jordan; Deng, Zhengtao; Stultz, Collin M; Lu, Timothy K

2014-10-01

Many natural underwater adhesives harness hierarchically assembled amyloid nanostructures to achieve strong and robust interfacial adhesion under dynamic and turbulent environments. Despite recent advances, our understanding of the molecular design, self-assembly and structure-function relationships of these natural amyloid fibres remains limited. Thus, designing biomimetic amyloid-based adhesives remains challenging. Here, we report strong and multi-functional underwater adhesives obtained from fusing mussel foot proteins (Mfps) of Mytilus galloprovincialis with CsgA proteins, the major subunit of Escherichia coli amyloid curli fibres. These hybrid molecular materials hierarchically self-assemble into higher-order structures, in which, according to molecular dynamics simulations, disordered adhesive Mfp domains are exposed on the exterior of amyloid cores formed by CsgA. Our fibres have an underwater adhesion energy approaching 20.9 mJ m(-2), which is 1.5 times greater than the maximum of bio-inspired and bio-derived protein-based underwater adhesives reported thus far. Moreover, they outperform Mfps or curli fibres taken on their own and exhibit better tolerance to auto-oxidation than Mfps at pH ≥ 7.0.

pH-Sensitive Reversible Programmed Targeting Strategy by the Self-Assembly/Disassembly of Gold Nanoparticles.

Science.gov (United States)

Ma, Jinlong; Hu, Zhenpeng; Wang, Wei; Wang, Xinyu; Wu, Qiang; Yuan, Zhi

2017-05-24

A reversible programmed targeting strategy could achieve high tumor accumulation due to its long blood circulation time and high cellular internalization. Here, targeting ligand-modified poly(ethylene glycol) (PEG-ligand), dibutylamines (Bu), and pyrrolidinamines (Py) were introduced on the surface of gold nanoparticles (Au NPs) for reversible shielding/deshielding of the targeting ligands by pH-responsive self-assembly. Hydrophobic interaction and steric repulsion are the main driving forces for the self-assembly/disassembly of Au NPs. The precise self-assembly (pH ≥ 7.2) and disassembly (pH ≤ 6.8) of Au NPs with different ligands could be achieved by fine-tuning the modifying molar ratio of Bu and Py (R m ), which followed the formula R m = 1/(-0.0013X 2 + 0.0323X + 1), in which X is the logarithm of the partition coefficient of the targeting ligand. The assembled/disassembled behavior of Au NPs at pH 7.2 and 6.8 was confirmed by transmission electron microscopy and dynamic light scattering. Enzyme-linked immunosorbent assays and cellular uptake studies showed that the ligands could be buried inside the assembly and exposed when disassembled. More importantly, this process was reversible, which provides the possibility of prolonging blood circulation by shielding ligands associated with the NPs that were effused from tumor tissue.

Multi-Agent Cooperative Target Search

Directory of Open Access Journals (Sweden)

Jinwen Hu

2014-05-01

Full Text Available This paper addresses a vision-based cooperative search for multiple mobile ground targets by a group of unmanned aerial vehicles (UAVs with limited sensing and communication capabilities. The airborne camera on each UAV has a limited field of view and its target discriminability varies as a function of altitude. First, by dividing the whole surveillance region into cells, a probability map can be formed for each UAV indicating the probability of target existence within each cell. Then, we propose a distributed probability map updating model which includes the fusion of measurement information, information sharing among neighboring agents, information decay and transmission due to environmental changes such as the target movement. Furthermore, we formulate the target search problem as a multi-agent cooperative coverage control problem by optimizing the collective coverage area and the detection performance. The proposed map updating model and the cooperative control scheme are distributed, i.e., assuming that each agent only communicates with its neighbors within its communication range. Finally, the effectiveness of the proposed algorithms is illustrated by simulation.

Surrogate fuel assembly multi-axis shaker tests to simulate normal conditions of rail and truck transport

Energy Technology Data Exchange (ETDEWEB)

McConnell, Paul E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Koenig, Greg John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Uncapher, William Leonard [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Grey, Carissa [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Engelhardt, Charles [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Saltzstein, Sylvia J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sorenson, Ken B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2016-05-01

This report describes the third set of tests (the “DCLa shaker tests”) of an instrumented surrogate PWR fuel assembly. The purpose of this set of tests was to measure strains and accelerations on Zircaloy-4 fuel rods when the PWR assembly was subjected to rail and truck loadings simulating normal conditions of transport when affixed to a multi-axis shaker. This is the first set of tests of the assembly simulating rail normal conditions of transport.

Structural impact of creep in tungsten monoblock divertor target at 20 MW/m2

Directory of Open Access Journals (Sweden)

Muyuan Li

2018-01-01

Full Text Available In order to increase erosion lifetime of the divertor target, in the 2nd design phase of R&D work package ‘Divertor’ for European DEMO, armor thickness of tungsten monoblock divertor target is increased from 5 mm to 8 mm. By increasing armor thickness, surface temperature increases nearly linearly, which makes effect of creep no longer negligible at slow transients of 20 MW/m2. In this work, structural impact of creep in tungsten monoblock divertor target is for the first time quantitatively analyzed with the aid of finite element method. The numerical simulations have revealed that creep results in an increase of inelastic strain accumulation. With increasing armor thickness, tensile surface stress along x-axis (the longer edge at the plasma-facing surface of tungsten monoblock reduces, while surface stress along z-axis (axial direction of the cooling tube changes from tensile to compressive. Creep will accelerate this change. With increasing grain size, creep strain accumulation at loading surface increases due to higher creep rates, while plastic strain accumulation decreases. Creep can mitigate the risk of deep cracking by reducing the driving force for crack opening, and has a positive impact for preventing the contact between the upper parts of neighboring monoblocks in high heat flux tests.

Comparison of Different Assembling Techniques Regarding Cost, Durability, and Ecology - A Survey of Multi-layer Wooden Panel Assembly Load-Bearing Construction Elements

Directory of Open Access Journals (Sweden)

Dietrich Buck

2015-10-01

Full Text Available Wood is a pure, sustainable, renewable material. The increasing use of wood for construction can improve its sustainability. There are various techniques to assemble multi-layer wooden panels into prefabricated, load-bearing construction elements. However, comparative market and economy studies are still scarce. In this study, the following assembling techniques were compared: laminating, nailing, stapling, screwing, stress laminating, doweling, dovetailing, and wood welding. The production costs, durability, and ecological considerations were presented. This study was based on reviews of published works and information gathered from 27 leading wood product manufacturing companies in six European countries. The study shows that the various techniques of assembling multi-layer wooden construction panel elements are very different. Cross laminated timber (CLT exhibited the best results in terms of cost and durability. With regard to ecological concerns, dovetailing is the best. Taking into account both durability and ecological considerations, wooden screw-doweling is the best. These alternatives give manufacturers some freedom of choice regarding the visibility of surfaces and the efficient use of lower-quality timber. CLT is the most cost-effective, is not patented, and is a well-established option on the market today.

Extending multi-tenant architectures: a database model for a multi-target support in SaaS applications

Science.gov (United States)

Rico, Antonio; Noguera, Manuel; Garrido, José Luis; Benghazi, Kawtar; Barjis, Joseph

2016-05-01

Multi-tenant architectures (MTAs) are considered a cornerstone in the success of Software as a Service as a new application distribution formula. Multi-tenancy allows multiple customers (i.e. tenants) to be consolidated into the same operational system. This way, tenants run and share the same application instance as well as costs, which are significantly reduced. Functional needs vary from one tenant to another; either companies from different sectors run different types of applications or, although deploying the same functionality, they do differ in the extent of their complexity. In any case, MTA leaves one major concern regarding the companies' data, their privacy and security, which requires special attention to the data layer. In this article, we propose an extended data model that enhances traditional MTAs in respect of this concern. This extension - called multi-target - allows MT applications to host, manage and serve multiple functionalities within the same multi-tenant (MT) environment. The practical deployment of this approach will allow SaaS vendors to target multiple markets or address different levels of functional complexity and yet commercialise just one single MT application. The applicability of the approach is demonstrated via a case study of a real multi-tenancy multi-target (MT2) implementation, called Globalgest.

Composite Structural Analysis of Flat-Back Shaped Blade for Multi-MW Class Wind Turbine

Science.gov (United States)

Kim, Soo-Hyun; Bang, Hyung-Joon; Shin, Hyung-Ki; Jang, Moon-Seok

2014-06-01

This paper provides an overview of failure mode estimation based on 3D structural finite element (FE) analysis of the flat-back shaped wind turbine blade. Buckling stability, fiber failure (FF), and inter-fiber failure (IFF) analyses were performed to account for delamination or matrix failure of composite materials and to predict the realistic behavior of the entire blade region. Puck's fracture criteria were used for IFF evaluation. Blade design loads applicable to multi-megawatt (MW) wind turbine systems were calculated according to the Germanischer Lloyd (GL) guideline and the International Electrotechnical Commission (IEC) 61400-1 standard, under Class IIA wind conditions. After the post-processing of final load results, a number of principal load cases were selected and converted into applied forces at the each section along the blade's radius of the FE model. Nonlinear static analyses were performed for laminate failure, FF, and IFF check. For buckling stability, linear eigenvalue analysis was performed. As a result, we were able to estimate the failure mode and locate the major weak point.

Simulation and development of a multi-leg homogeniser concentrating assembly for concentrated photovoltaic (CPV) system with electrical rating analysis

International Nuclear Information System (INIS)

Burhan, Muhammad; Chua, Kian Jon Ernest; Ng, Kim Choon

2016-01-01

Highlights: • Novel multi-leg homogeniser concentrating assembly is developed for CPV system. • Single set of concentrator, concentrates sunlight on 4 MJCs with 1° acceptance angle. • The system performance is analyzed through experiment and ray tracing simulation. • Mini two axis solar tracker, with high tracking accuracy, is developed and tested. • Electrical rating analysis accurately estimates CPV system performance in any region. - Abstract: Concentrated photovoltaic (CPV) system utilizing multi-junction solar cells, is the main focus for current research, offering highest efficiency among all photovoltaic systems. The main aspect of CPV system is the design and performance of concentrating assembly, as it determines the performance of whole CPV system. However, the conventional design of CPV concentrating assembly dedicates one concentrator for each solar cell, in which single concentrator is capable to concentrate solar radiation onto single solar cell. This paper proposes a novel concentrating assembly for CPV system, which is designed to concentrate solar radiation onto four multi-junction solar cells with a single set of concentrators. The proposed design not only can reduce the number of concentrators and assembly efforts for CPV systems, but also achieved an acceptance angle of 1°. In this paper, the proposed multi-leg homogeniser CPV concentrating assembly is designed, developed, experimentally tested and verified through ray tracing simulation. The paper also discuss the development of mini, precise and accurate but cost effective two axis solar tracker for CPV system, which can be installed at any location even at rooftop of residential buildings, unlike conventional large scale CPV systems. Moreover, through the electrical rating analysis of the developed CPV system, its performance can be accurately estimated in any region.

Surrogate fuel assembly multi-axis shaker tests to simulate normal conditions of rail and truck transport

Energy Technology Data Exchange (ETDEWEB)

McConnell, Paul E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Koenig, Greg John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Uncapher, William Leonard [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Grey, Carissa [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Engelhardt, Charles [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Saltzstein, Sylvia J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sorenson, Ken B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2016-05-12

This report describes the third set of tests (the “DCL^a shaker tests”) of an instrumented surrogate PWR fuel assembly. The purpose of this set of tests was to measure strains and accelerations on Zircaloy-4 fuel rods when the PWR assembly was subjected to rail and truck loadings simulating normal conditions of transport when affixed to a multi-axis shaker. This is the first set of tests of the assembly simulating rail normal conditions of transport.

Research on multi - channel interactive virtual assembly system for power equipment under the “VR+” era

Science.gov (United States)

Ren, Yilong; Duan, Xitong; Wu, Lei; He, Jin; Xu, Wu

2017-06-01

With the development of the “VR+” era, the traditional virtual assembly system of power equipment has been unable to satisfy our growing needs. In this paper, based on the analysis of the traditional virtual assembly system of electric power equipment and the application of VR technology in the virtual assembly system of electric power equipment in our country, this paper puts forward the scheme of establishing the virtual assembly system of power equipment: At first, we should obtain the information of power equipment, then we should using OpenGL and multi texture technology to build 3D solid graphics library. After the completion of three-dimensional modeling, we can use the dynamic link library DLL package three-dimensional solid graphics generation program to realize the modularization of power equipment model library and power equipment model library generated hidden algorithm. After the establishment of 3D power equipment model database, we set up the virtual assembly system of 3D power equipment to separate the assembly operation of the power equipment from the space. At the same time, aiming at the deficiency of the traditional gesture recognition algorithm, we propose a gesture recognition algorithm based on improved PSO algorithm for BP neural network data glove. Finally, the virtual assembly system of power equipment can really achieve multi-channel interaction function.

An Assemblable, Multi-Angle Fluorescence and Ellipsometric Microscope

Science.gov (United States)

Nguyen, Victoria; Rizzo, John

2016-01-01

We introduce a multi-functional microscope for research laboratories that have significant cost and space limitations. The microscope pivots around the sample, operating in upright, inverted, side-on and oblique geometries. At these geometries it is able to perform bright-field, fluorescence and qualitative ellipsometric imaging. It is the first single instrument in the literature to be able to perform all of these functionalities. The system can be assembled by two undergraduate students from a provided manual in less than a day, from off-the-shelf and 3D printed components, which together cost approximately $16k at 2016 market prices. We include a highly specified assembly manual, a summary of design methodologies, and all associated 3D-printing files in hopes that the utility of the design outlives the current component market. This open design approach prepares readers to customize the instrument to specific needs and applications. We also discuss how to select household LEDs as low-cost light sources for fluorescence microscopy. We demonstrate the utility of the microscope in varied geometries and functionalities, with particular emphasis on studying hydrated, solid-supported lipid films and wet biological samples. PMID:27907008

An Assemblable, Multi-Angle Fluorescence and Ellipsometric Microscope.

Directory of Open Access Journals (Sweden)

Victoria Nguyen

Full Text Available We introduce a multi-functional microscope for research laboratories that have significant cost and space limitations. The microscope pivots around the sample, operating in upright, inverted, side-on and oblique geometries. At these geometries it is able to perform bright-field, fluorescence and qualitative ellipsometric imaging. It is the first single instrument in the literature to be able to perform all of these functionalities. The system can be assembled by two undergraduate students from a provided manual in less than a day, from off-the-shelf and 3D printed components, which together cost approximately $16k at 2016 market prices. We include a highly specified assembly manual, a summary of design methodologies, and all associated 3D-printing files in hopes that the utility of the design outlives the current component market. This open design approach prepares readers to customize the instrument to specific needs and applications. We also discuss how to select household LEDs as low-cost light sources for fluorescence microscopy. We demonstrate the utility of the microscope in varied geometries and functionalities, with particular emphasis on studying hydrated, solid-supported lipid films and wet biological samples.

Multi-Stage System for Automatic Target Recognition

Science.gov (United States)

Chao, Tien-Hsin; Lu, Thomas T.; Ye, David; Edens, Weston; Johnson, Oliver

2010-01-01

A multi-stage automated target recognition (ATR) system has been designed to perform computer vision tasks with adequate proficiency in mimicking human vision. The system is able to detect, identify, and track targets of interest. Potential regions of interest (ROIs) are first identified by the detection stage using an Optimum Trade-off Maximum Average Correlation Height (OT-MACH) filter combined with a wavelet transform. False positives are then eliminated by the verification stage using feature extraction methods in conjunction with neural networks. Feature extraction transforms the ROIs using filtering and binning algorithms to create feature vectors. A feedforward back-propagation neural network (NN) is then trained to classify each feature vector and to remove false positives. The system parameter optimizations process has been developed to adapt to various targets and datasets. The objective was to design an efficient computer vision system that can learn to detect multiple targets in large images with unknown backgrounds. Because the target size is small relative to the image size in this problem, there are many regions of the image that could potentially contain the target. A cursory analysis of every region can be computationally efficient, but may yield too many false positives. On the other hand, a detailed analysis of every region can yield better results, but may be computationally inefficient. The multi-stage ATR system was designed to achieve an optimal balance between accuracy and computational efficiency by incorporating both models. The detection stage first identifies potential ROIs where the target may be present by performing a fast Fourier domain OT-MACH filter-based correlation. Because threshold for this stage is chosen with the goal of detecting all true positives, a number of false positives are also detected as ROIs. The verification stage then transforms the regions of interest into feature space, and eliminates false positives using an

Manufacturing and testing of a prototypical divertor vertical target for ITER

Energy Technology Data Exchange (ETDEWEB)

Merola, M. E-mail: merolam@ipp.mpg.de; Ploechl, L.; Chappuis, Ph.; Escourbiac, F.; Grattarola, M.; Smid, I.; Tivey, R.; Vieider, G

2000-12-01

After an extensive R and D activity, a medium-scale divertor vertical target prototype has been manufactured by the EU Home Team. This component contains all the main features of the corresponding ITER divertor design and consists of two units with one cooling channel each, assembled together and having an overall length and width of about 600 and 50 mm, respectively. The upper part of the prototype has a tungsten macro-brush armour, whereas the lower part is covered by CFC monoblocks. A number of joining techniques were required to manufacture this component as well as an appreciable effort in the development of suitable non-destructive testing methods. The component was high heat flux tested in FE200 electron beam facility at Le Creusot, France. It endured 100 cycles at 5 MW/m{sup 2}, 1000 cycles at 10 MW/m{sup 2} and more then 1000 cycles at 15-20 MW/m{sup 2}. The final critical heat flux test reached a value in excess of 30 MW/m{sup 2}.

34 GHz, 45 MW pulsed magnicon

International Nuclear Information System (INIS)

Nezhevenko, Oleg A.; LaPointe, Michael A.; Yakovlev, Vyacheslav P.; Hirshfield, Jay L.; Serdobintsev, Gennady V.; Kuznetsov, Gennady I.; Persov, Boris Z.; Fix, Alexander

2002-01-01

A high efficiency, high power magnicon at 34.272 GHz has been designed and built as a microwave source to develop RF technology for a future multi-TeV electron-positron linear collider. The tube is designed to provide a peak output power of ∼45 MW in a 1 microsecond pulse, with a gain of 55 dB, using a 500 kV, 220 A, 1 mm-diameter electron beam. The status of the tube itself as well as the near-term experimental program is presented

Modeling and Finite Element Analysis of Load-Carrying Performance of a Wind Turbine Considering the Influence of Assembly Factors

Directory of Open Access Journals (Sweden)

Jianmei Wang

2017-03-01

Full Text Available In this work, a wind turbine shrink disk is used as the research object to investigate load-carrying performance of a multi-layer interference fit, and the theoretical model and finite element model are constructed. According to those models, a MW-level turbine shrink disk is designed, and a test device is developed to apply torque to this turbine shrink disk by hydraulic jack. Then, the circumferential slip between the contact surfaces is monitored and the slip of all contact surfaces is zero. This conclusion verifies the reasonability of the proposed models. The effect of the key influencing factors, such as machining deviation, assembly clearance and propel stroke, were analyzed. The contact pressure and load torque of the mating surfaces were obtained by building typical models with different parameters using finite element analysis (FEA. The results show that the minimum assembly clearance and the machining deviation within the machining range have little influence on load-carrying performance of multi-layer interference fit, while having a greater influence on the maximum assembly clearance and the propel stroke. The results also show that the load-carrying performance of a multiple-layer interference fit can be ensured only if the key factors are set within a reasonable design range. To avoid the abnormal operation of equipment caused by insufficient load torque, the propel stroke during practical assembly should be at least 0.95 times the designed propel stroke, which is significant in guiding the design and assembly of the multi-layer interference fit.

Development of MW gyrotrons for fusion devices by University of Tsukuba

International Nuclear Information System (INIS)

Minami, R.; Kariya, T.; Imai, T.; Numakura, T.; Endo, Y.; Nakabayashi, H.; Eguchi, T.; Shimozuma, T.; Kubo, S.; Yoshimura, Y.; Igami, H.; Takahashi, H.; Mutoh, T.; Ito, S.; Idei, H.; Zushi, H.; Yamaguchi, Y.; Sakamoto, Keishi; Mitsunaka, Y.

2012-11-01

Over-1 MW power gyrotrons for electron cyclotron heating (ECH) have been developed in the joint program of NIFS and University of Tsukuba. The obtained maximum outputs are 1.9 MW for 0.1 s on the 77 GHz Large Helical Device (LHD) tube and 1.0 MW for 1 ms on the 28 GHz GAMMA 10 one, which are new records in these frequency ranges. In long pulse operation, 300 kW for 40 min at 77 GHz and 540 kW for 2 s at 28 GHz were achieved. A new program of 154 GHz 1 MW development has started for high density plasma heating in LHD and the first tube has been fabricated. These lower frequency tubes like 77 GHz or 28 GHz one are also important for advanced magnetic fusion devices, which use Electron Bernstein Wave (EBW) heating / current drive. As a next activity of 28 GHz gyrotron, we have already started the development of over-1.5 MW gyrotron and a new design study of 28 GHz / 35 GHz dual frequency gyrotron, which indicates the practicability of the multi-purpose gyrotron. (author)

Simulation and development of a multi-leg homogeniser concentrating assembly for concentrated photovoltaic (CPV) system with electrical rating analysis

KAUST Repository

Burhan, Muhammad

2016-03-09

Concentrated photovoltaic (CPV) system utilizing multi-junction solar cells, is the main focus for current research, offering highest efficiency among all photovoltaic systems. The main aspect of CPV system is the design and performance of concentrating assembly, as it determines the performance of whole CPV system. However, the conventional design of CPV concentrating assembly dedicates one concentrator for each solar cell, in which single concentrator is capable to concentrate solar radiation onto single solar cell. This paper proposes a novel concentrating assembly for CPV system, which is designed to concentrate solar radiation onto four multi-junction solar cells with a single set of concentrators. The proposed design not only can reduce the number of concentrators and assembly efforts for CPV systems, but also achieved an acceptance angle of 1°. In this paper, the proposed multi-leg homogeniser CPV concentrating assembly is designed, developed, experimentally tested and verified through ray tracing simulation. The paper also discuss the development of mini, precise and accurate but cost effective two axis solar tracker for CPV system, which can be installed at any location even at rooftop of residential buildings, unlike conventional large scale CPV systems. Moreover, through the electrical rating analysis of the developed CPV system, its performance can be accurately estimated in any region. © 2016 Elsevier Ltd. All rights reserved.

Simulation and development of a multi-leg homogeniser concentrating assembly for concentrated photovoltaic (CPV) system with electrical rating analysis

KAUST Repository

Burhan, Muhammad; Chua, Kian Jon Ernest; Ng, Kim Choon

2016-01-01

Concentrated photovoltaic (CPV) system utilizing multi-junction solar cells, is the main focus for current research, offering highest efficiency among all photovoltaic systems. The main aspect of CPV system is the design and performance of concentrating assembly, as it determines the performance of whole CPV system. However, the conventional design of CPV concentrating assembly dedicates one concentrator for each solar cell, in which single concentrator is capable to concentrate solar radiation onto single solar cell. This paper proposes a novel concentrating assembly for CPV system, which is designed to concentrate solar radiation onto four multi-junction solar cells with a single set of concentrators. The proposed design not only can reduce the number of concentrators and assembly efforts for CPV systems, but also achieved an acceptance angle of 1°. In this paper, the proposed multi-leg homogeniser CPV concentrating assembly is designed, developed, experimentally tested and verified through ray tracing simulation. The paper also discuss the development of mini, precise and accurate but cost effective two axis solar tracker for CPV system, which can be installed at any location even at rooftop of residential buildings, unlike conventional large scale CPV systems. Moreover, through the electrical rating analysis of the developed CPV system, its performance can be accurately estimated in any region. © 2016 Elsevier Ltd. All rights reserved.

Multilevel converters for 10 MW Wind Turbines

DEFF Research Database (Denmark)

Ma, Ke; Blaabjerg, Frede

2011-01-01

Several promising multi-level converter configurations for 10 MW Wind Turbines both with direct drive and one-stage gear box drive using Permanent Magnet Synchronous Generator (PMSG) are proposed, designed and compared. Reliability is a crucial indicator for large scale wind power converters...... that the three-level and five-level H-bridge converter topologies both have potential to achieve improved thermal performances compared to the three-level Neutral-Point-Clamped converter topology in the wind power application....

Self-Assembled Smart Nanocarriers for Targeted Drug Delivery.

Science.gov (United States)

Cui, Wei; Li, Junbai; Decher, Gero

2016-02-10

Nanostructured drug-carrier systems promise numerous benefits for drug delivery. They can be engineered to precisely control drug-release rates or to target specific sites within the body with a specific amount of therapeutic agent. However, to achieve the best therapeutic effects, the systems should be designed for carrying the optimum amount of a drug to the desired target where it should be released at the optimum rate for a specified time. Despite numerous attempts, fulfilling all of these requirements in a synergistic way remains a huge challenge. The trend in drug delivery is consequently directed toward integrated multifunctional carrier systems, providing selective recognition in combination with sustained or triggered release. Capsules as vesicular systems enable drugs to be confined for controlled release. Furthermore, carriers modified with recognition groups can enhance the capability of encapsulated drug efficacy. Here, recent advances are reviewed regarding designing and preparing assembled capsules with targeting ligands or size controllable for selective recognition in drug delivery. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Multi-potent Natural Scaffolds Targeting Amyloid Cascade: In Search of Alzheimer's Disease Therapeutics.

Science.gov (United States)

Chakraborty, Sandipan

2017-01-01

Alzheimer's Disease (AD) once considered a rare disorder emerges as a major health concern in recent times. The disease pathogenesis is very complex and yet to be understood completely. However, "Amyloid Cascade" is the central event in disease pathogenesis. Several proteins of the amyloid cascade are currently being considered as potential targets for AD therapeutics discovery. Many potential compounds are in clinical trials, but till now there is no known cure for the disease. Recent years have witnessed remarkable research interest in the search of novel concepts in drug designing for AD. Multi-targeted ligand design is a paradigm shift in conventional drug discovery. In this process rather than designing ligands targeting a single receptor, novel ligands have been designed/ synthesized that can simultaneously target many pathways involved in disease pathogenesis. Here, recent developments in computational drug designing protocols to identify multi-targeted ligand for AD have been discussed. Therapeutic potential of different multi-potent compounds also has been discussed briefly. Prime emphasis has been given to multi-potent ligand from natural resources. Polyphenols are an interesting group of compounds which show efficacy against a wide range of disease and have the property to exhibit multi-potency. Several groups attempted to identify novel multi-potent phytochemicals for AD therapy. Multi-potency of several polyphenols or compounds synthesized using the poly-phenolic scaffolds have been briefly discussed here. However, the multi-targeted drug designing for AD is still in early stages, more advancement in drug designing method/algorithm developments is urgently required to discover more efficient compounds for AD therapeutics. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

An Automatic Multi-Target Independent Analysis Framework for Non-Planar Infrared-Visible Registration.

Science.gov (United States)

Sun, Xinglong; Xu, Tingfa; Zhang, Jizhou; Zhao, Zishu; Li, Yuankun

2017-07-26

In this paper, we propose a novel automatic multi-target registration framework for non-planar infrared-visible videos. Previous approaches usually analyzed multiple targets together and then estimated a global homography for the whole scene, however, these cannot achieve precise multi-target registration when the scenes are non-planar. Our framework is devoted to solving the problem using feature matching and multi-target tracking. The key idea is to analyze and register each target independently. We present a fast and robust feature matching strategy, where only the features on the corresponding foreground pairs are matched. Besides, new reservoirs based on the Gaussian criterion are created for all targets, and a multi-target tracking method is adopted to determine the relationships between the reservoirs and foreground blobs. With the matches in the corresponding reservoir, the homography of each target is computed according to its moving state. We tested our framework on both public near-planar and non-planar datasets. The results demonstrate that the proposed framework outperforms the state-of-the-art global registration method and the manual global registration matrix in all tested datasets.

Novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery

Directory of Open Access Journals (Sweden)

Liu J

2013-12-01

Full Text Available Jianfeng Liu, Jinjian Liu, Hongyan Xu, Yumin Zhang, Liping Chu, Qingfen Liu, Naling Song, Cuihong YangTianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science and Peking Union Medical College, People's Republic of ChinaAbstract: The poor aqueous solubility and low bioavailability of curcumin restrict its clinical application for cancer treatment. In this study, a novel tumor-targeting nanofiber carrier was developed to improve the solubility and tumor-targeting ability of curcumin using a self-assembled Nap-GFFYG-RGD peptide. The morphologies of the peptide nanofiber and the curcumin-encapsulated nanofiber were visualized by transmission electron microscopy. The tumor-targeting activity of the curcumin-encapsulated Nap-GFFYG-RGD peptide nanofiber (f-RGD-Cur was studied in vitro and in vivo, using Nap-GFFYG-RGE peptide nanofiber (f-RGE-Cur as the control. Curcumin was encapsulated into the peptide nanofiber, which had a diameter of approximately 10–20 nm. Curcumin showed sustained-release behavior from the nanofibers in vitro. f-RGD-Cur showed much higher cellular uptake in αvβ3 integrin-positive HepG2 liver carcinoma cells than did non-targeted f-RGE-Cur, thereby leading to significantly higher cytotoxicity. Ex vivo studies further demonstrated that curcumin could accumulate markedly in mouse tumors after administration of f-RGD-Cur via the tail vein. These results indicate that Nap-GFFYG-RGD peptide self-assembled nanofibers are a promising hydrophobic drug delivery system for targeted treatment of cancer.Keywords: nanofiber, tumor-targeting, self-assembling, curcumin, drug delivery

Due date assignment procedures with dynamically updated coefficients for multi-level assembly job shops

NARCIS (Netherlands)

Adam, N.R.; Bertrand, J.W.M.; Morehead, D.C.; Surkis, J.

1993-01-01

This paper presents a study of due date assignment procedures in job shop environments where multi-level assembly jobs are processed and due dates are internally assigned. Most of the reported studies in the literature have focused on string type jobs. We propose a dynamic update approach (which

Novel apigenin-loaded sodium hyaluronate nano-assemblies for targeting tumor cells.

Science.gov (United States)

Zhao, Ting; He, Yue; Chen, Huali; Bai, Yan; Hu, Wenjing; Zhang, Liangke

2017-12-01

We aimed to construct a novel nano-assembly carrying apigenin (APG), a hydrophobic drug, and to evaluate its in vitro targeting ability for A549 cells overexpressing CD44 receptors. The apigenin-loaded sodium hyaluronate nano-assemblies (APG/SH-NAs) were assembled by multiple non-covalent interactions between sodium hyaluronate (SH) and APG. The prepared APG/SH-NAs exhibited a small average size and narrow particle size distribution. In addition, satisfactory encapsulation efficiency and drug loading were obtained. The drug release curves indicated that APG/SH-NAs achieved a sustainable drug-release effect due to the presence of hydrophilic materials. The in vitro cytotoxicity of APG/SH-NAs against A549 cells and HepG2 cells was evaluated, and the results indicated that the prepared APG/SH-NA showed higher cytotoxicity compared to apigenin suspensions. When CD44 receptors on the surface of A549 cells were blocked by the addition of excess SH, the cytotoxicity of APG/SH-NA was significantly reduced. However, similar phenomena were not observed in HepG2 cells with relatively low CD44 receptor expression. The resulting APG/SH-NAs could efficiently facilitate the internalization of APG into A549 cells, which might be due to their high affinity for CD44 receptors. Moreover, the apoptotic rate of APG/SH-NAs through receptor-mediated endocytosis mechanism was higher than that of the other groups in A549 cells. Thus, such nano-assemblies were considered to be an effective transport system with excellent affinity for CD44 receptors to allow the SH-mediated targeted delivery of APG. Copyright © 2017. Published by Elsevier Ltd.

'Multi-epitope-targeted' immune-specific therapy for a multiple sclerosis-like disease via engineered multi-epitope protein is superior to peptides.

Directory of Open Access Journals (Sweden)

Nathali Kaushansky

Full Text Available Antigen-induced peripheral tolerance is potentially one of the most efficient and specific therapeutic approaches for autoimmune diseases. Although highly effective in animal models, antigen-based strategies have not yet been translated into practicable human therapy, and several clinical trials using a single antigen or peptidic-epitope in multiple sclerosis (MS yielded disappointing results. In these clinical trials, however, the apparent complexity and dynamics of the pathogenic autoimmunity associated with MS, which result from the multiplicity of potential target antigens and "epitope spread", have not been sufficiently considered. Thus, targeting pathogenic T-cells reactive against a single antigen/epitope is unlikely to be sufficient; to be effective, immunospecific therapy to MS should logically neutralize concomitantly T-cells reactive against as many major target antigens/epitopes as possible. We investigated such "multi-epitope-targeting" approach in murine experimental autoimmune encephalomyelitis (EAE associated with a single ("classical" or multiple ("complex" anti-myelin autoreactivities, using cocktail of different encephalitogenic peptides vis-a-vis artificial multi-epitope-protein (designated Y-MSPc encompassing rationally selected MS-relevant epitopes of five major myelin antigens, as "multi-epitope-targeting" agents. Y-MSPc was superior to peptide(s in concomitantly downregulating pathogenic T-cells reactive against multiple myelin antigens/epitopes, via inducing more effective, longer lasting peripheral regulatory mechanisms (cytokine shift, anergy, and Foxp3+ CTLA4+ regulatory T-cells. Y-MSPc was also consistently more effective than the disease-inducing single peptide or peptide cocktail, not only in suppressing the development of "classical" or "complex EAE" or ameliorating ongoing disease, but most importantly, in reversing chronic EAE. Overall, our data emphasize that a "multi-epitope-targeting" strategy is required for

Real-time capture of seismic waves using high-rate multi-GNSS observations: Application to the 2015 Mw 7.8 Nepal earthquake

Science.gov (United States)

Geng, Tao; Xie, Xin; Fang, Rongxin; Su, Xing; Zhao, Qile; Liu, Gang; Li, Heng; Shi, Chuang; Liu, Jingnan

2016-01-01

The variometric approach is investigated to measure real-time seismic waves induced by the 2015 Mw 7.8 Nepal earthquake with high-rate multi-GNSS observations, especially with the contribution of newly available BDS. The velocity estimation using GPS + BDS shows an additional improvement of around 20% with respect to GPS-only solutions. We also reconstruct displacements by integrating GNSS-derived velocities after a linear trend removal (IGV). The displacement waveforms with accuracy of better than 5 cm are derived when postprocessed GPS precise point positioning results are used as ground truth, even if those stations have strong ground motions and static offsets of up to 1-2 m. GNSS-derived velocity and displacement waveforms with the variometric approach are in good agreement with results from strong motion data. We therefore conclude that it is feasible to capture real-time seismic waves with multi-GNSS observations using the IGV-enhanced variometric approach, which has critical implications for earthquake early warning, tsunami forecasting, and rapid hazard assessment.

Multi-target Wastage Phenomena on Steam Generator Tubes During an SWR Event

International Nuclear Information System (INIS)

Jeong, Ji Young; Kim, Jong Man; Kim, Tae Joon; Eoh, Jae Hyuk; Choi, Jong Hyeun; Lee, Yong Bum

2011-01-01

. This is called 'multi-target wastage'. Therefore, it is very important to predict these phenomena quantitatively from the view point of designing a steam generator and its leak detection systems. In this study, to investigate the additional tube rupture behavior near the failed tube, multi-target wastage tests were carried out for the simulated target assembly made with a modified 9Cr-1Mo steel tube bundle

Development of In-pile Plug Assembly and Primary Shutter for Cold Neutron Guide System

Energy Technology Data Exchange (ETDEWEB)

Shin, Jin Won; Cho, Yeong Garp; Ryu, Jeong Soo; Lee, Jung Hee [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2008-12-15

The HANARO, a 30 MW multi-purpose research reactor in Korea, will be equipped with a neutron guide system, in order to transport cold neutrons from the neutron source to the neutron scattering instruments in the neutron guide hall near the reactor building. The neutron guide system of HANARO consists of the in-pile plug assembly with in-pile guides, the primary shutter with in-shutter guides, the neutron guides in the guide shielding room with dedicated secondary shutters, and the neutron guides connected to the instruments in the neutron guide hall. The functions of the in-pile plug assembly are to shield the reactor environment from a nuclear radiation and to support the neutron guides and maintain them precisely oriented. The primary shutter is a mechanical device to be installed just after the in-pile plug assembly, which stops neutron flux on demand. This report describes the mechanical design, fabrication, and installation procedure of the in-pile plug assembly and the primary shutter for the neutron guide system at HANARO. A special tool and procedure for a replacement of in-pile plug and guide cassette is also presented with the interface condition in the reactor hall.

Operating experiences with 1 MW steam generator

Energy Technology Data Exchange (ETDEWEB)

Sano, A; Kanamori, A; Tsuchiya, T

1975-07-01

1 MW steam generator, which was planned as the first stage of steam generator development in Power Reactor and Nuclear Fuel Corp. (PNC) in Japan, is a single-unit, once-through, integrated shell and tube type with multi-helical coil tubes. It was completed in Oarai Engineering Center of PNC in March of 1971, and the various performance tests were carried out up to April, 1972. After the dismantle of the steam generator for structural inspection and material test, it was restored with some improvements. In this second 1 MW steam generator, small leak occurred twice during normal operation. After repairing the failure, the same kind of performance tests as the first steam generator were conducted in order to verify the thermal insulation effect of argon gas in downcomer zone from March to June, 1974. In this paper the above operating experiences were presented including the outline of some performance test results. (author)

Development of a field pole of 1 MW-class HTS motor

International Nuclear Information System (INIS)

Yuan, S; Kimura, Y; Miki, M; Felder, B; Tsuzuki, K; Izumi, M; Ida, T; Umemoto, K; Aizawa, K; Yokoyama, M

2010-01-01

We report a field-pole high-temperature superconductor (HTS) magnet designed for 1 MW-class motor for propulsion. The field pole is assembled to the rotor of the radial-type motor. Each field pole is composed of HTS-Bi2223 tape wound into coils which have been piled up as a double pancake coils. In the design concept of the motor, we employ field poles without iron core. We prepared the test field-pole coil, whose dimension is smaller than the designed one for 1 MW, and tested its performances after cooling under self-field and external magnetic field. We verified the operation with the minimum bend radius of the coils required in the motor design, while keeping an optimal current which is lower than the critical current of the field-pole coil. The test HTS field poles were successfully cooled down and operated under a magnetic field ranging up to 5 T. We report the results of the test field-pole coil and the manufacture of a practical racetrack coil with Bi2223 and discuss the adaptability to 1 MW-class motors.

Development of a field pole of 1 MW-class HTS motor

Science.gov (United States)

Yuan, S.; Kimura, Y.; Miki, M.; Felder, B.; Tsuzuki, K.; Ida, T.; Izumi, M.; Umemoto, K.; Aizawa, K.; Yokoyama, M.

2010-06-01

We report a field-pole high-temperature superconductor (HTS) magnet designed for 1 MW-class motor for propulsion. The field pole is assembled to the rotor of the radial-type motor. Each field pole is composed of HTS-Bi2223 tape wound into coils which have been piled up as a double pancake coils. In the design concept of the motor, we employ field poles without iron core. We prepared the test field-pole coil, whose dimension is smaller than the designed one for 1 MW, and tested its performances after cooling under self-field and external magnetic field. We verified the operation with the minimum bend radius of the coils required in the motor design, while keeping an optimal current which is lower than the critical current of the field-pole coil. The test HTS field poles were successfully cooled down and operated under a magnetic field ranging up to 5 T. We report the results of the test field-pole coil and the manufacture of a practical racetrack coil with Bi2223 and discuss the adaptability to 1 MW-class motors.

12 MW

DEFF Research Database (Denmark)

Hasager, Charlotte Bay; Pena Diaz, Alfredo; Mikkelsen, Torben

'12MW: final report' is for the project with the full title ‘12 MW wind turbines: the scientific basis for their operation at 70 to 270 m height offshore’ that had the goal to experimentally investigate the wind and turbulence characteristics between 70 and 270 m above sea level and thereby...... establish the scientific basis relevant for the next generation of huge 12 MW wind turbines operating offshore. The project started 1st October 2005 and ended 31st March 2009. Firstly was conducted a 6-month experiment at the Horns Rev offshore wind farm deploying a lidar and a sodar on the transformer...

Targeting and Assembly of Components of the TOC Protein Import Complex at the Chloroplast Outer Envelope Membrane

Directory of Open Access Journals (Sweden)

Lynn G.L. Richardson

2014-06-01

Full Text Available The translocon at the outer envelope membrane of chloroplasts (TOC initiates the import of thousands of nuclear encoded preproteins required for chloroplast biogenesis and function. The multimeric TOC complex contains two GTP-regulated receptors, Toc34 and Toc159, which recognize the transit peptides of preproteins and initiate protein import through a β–barrel membrane channel, Toc75. Different isoforms of Toc34 and Toc159 assemble with Toc75 to form structurally and functionally diverse translocons, and the composition and levels of TOC translocons is required for the import of specific subsets of coordinately expressed proteins during plant growth and development. Consequently, the proper assembly of the TOC complexes is key to ensuring organelle homeostasis. This review will focus on our current knowledge of the targeting and assembly of TOC components to form functional translocons at the outer membrane. Our analyses reveal that the targeting of TOC components involves elements common to the targeting of other outer membrane proteins, but also include unique features that appear to have evolved to specifically facilitate assembly of the import apparatus.

Targeting and assembly of components of the TOC protein import complex at the chloroplast outer envelope membrane.

Science.gov (United States)

Richardson, Lynn G L; Paila, Yamuna D; Siman, Steven R; Chen, Yi; Smith, Matthew D; Schnell, Danny J

2014-01-01

The translocon at the outer envelope membrane of chloroplasts (TOC) initiates the import of thousands of nuclear encoded preproteins required for chloroplast biogenesis and function. The multimeric TOC complex contains two GTP-regulated receptors, Toc34 and Toc159, which recognize the transit peptides of preproteins and initiate protein import through a β-barrel membrane channel, Toc75. Different isoforms of Toc34 and Toc159 assemble with Toc75 to form structurally and functionally diverse translocons, and the composition and levels of TOC translocons is required for the import of specific subsets of coordinately expressed proteins during plant growth and development. Consequently, the proper assembly of the TOC complexes is key to ensuring organelle homeostasis. This review will focus on our current knowledge of the targeting and assembly of TOC components to form functional translocons at the outer membrane. Our analyses reveal that the targeting of TOC components involves elements common to the targeting of other outer membrane proteins, but also include unique features that appear to have evolved to specifically facilitate assembly of the import apparatus.

Robust Target Tracking with Multi-Static Sensors under Insufficient TDOA Information.

Science.gov (United States)

Shin, Hyunhak; Ku, Bonhwa; Nelson, Jill K; Ko, Hanseok

2018-05-08

This paper focuses on underwater target tracking based on a multi-static sonar network composed of passive sonobuoys and an active ping. In the multi-static sonar network, the location of the target can be estimated using TDOA (Time Difference of Arrival) measurements. However, since the sensor network may obtain insufficient and inaccurate TDOA measurements due to ambient noise and other harsh underwater conditions, target tracking performance can be significantly degraded. We propose a robust target tracking algorithm designed to operate in such a scenario. First, track management with track splitting is applied to reduce performance degradation caused by insufficient measurements. Second, a target location is estimated by a fusion of multiple TDOA measurements using a Gaussian Mixture Model (GMM). In addition, the target trajectory is refined by conducting a stack-based data association method based on multiple-frames measurements in order to more accurately estimate target trajectory. The effectiveness of the proposed method is verified through simulations.

Commissioning a Rotating Target Wheel Assembly for Heavy Element Studies

Science.gov (United States)

Fields, L. D.; Bennett, M. E.; Mayorov, D. A.; Folden, C. M.

2013-10-01

The heaviest elements are produced artificially by fusing nuclei of light elements within an accelerator to form heavier nuclei. The most direct method to increase the production rate of nuclei is to increase the beam intensity, necessitating the use of a rotating target to minimize damage to the target by deposited heat. Such a target wheel was constructed for heavy element research at Texas A&M University, Cyclotron Institute, consisting of a wheel with three banana-shaped target cutouts. The target is designed to rotate at 1700 rpm, and a fiber optic cable provides a signal to trigger beam pulsing in order to avoid irradiating the spokes between target segments. Following minor mechanical modifications and construction of a dedicated electrical panel, the rotating target assembly was commissioned for a beam experiment. A 15 MeV/u beam of 20Ne was delivered from the K500 cyclotron and detected by a ruggedized silicon detector. The beam pulsing response time was characterized as a function of the rational frequency of the target wheel. Preliminary analysis suggests that the K500 is capable of pulsing at rates of up to 250 Hz, which is sufficient for planned future experiments. Funded by DOE and NSF-REU Program.

Multi-small molecule conjugations as new targeted delivery carriers for tumor therapy

Directory of Open Access Journals (Sweden)

Shan L

2015-09-01

Full Text Available Lingling Shan,1 Ming Liu,2 Chao Wu,1 Liang Zhao,1 Siwen Li,3 Lisheng Xu,1 Wengen Cao,1 Guizhen Gao,1 Yueqing Gu3 1Institute of Pharmaceutical Biotechnology, School of Biology and Food Engineering, Suzhou University, Suzhou, People’s Republic of China; 2Department of Biology, University of South Dakota, Vermillion, SD, USA; 3Department of Biomedical Engineering, School of Life Science and Technology, China Pharmaceutical University, Nanjing, People’s Republic of China Abstract: In response to the challenges of cancer chemotherapeutics, including poor physicochemical properties, low tumor targeting ability, and harmful side effects, we developed a new tumor-targeted multi-small molecule drug delivery platform. Using paclitaxel (PTX as a model therapeutic, we prepared two prodrugs, ie, folic acid-fluorescein-5(6-isothiocyanate-arginine-paclitaxel (FA-FITC-Arg-PTX and folic acid-5-aminofluorescein-glutamic-paclitaxel (FA-5AF-Glu-PTX, composed of folic acid (FA, target, amino acids (Arg or Glu, linker, and fluorescent dye (fluorescein in vitro or near-infrared fluorescent dye in vivo in order to better understand the mechanism of PTX prodrug targeting. In vitro and acute toxicity studies demonstrated the low toxicity of the prodrug formulations compared with the free drug. In vitro and in vivo studies indicated that folate receptor-mediated uptake of PTX-conjugated multi-small molecule carriers induced high antitumor activity. Notably, compared with free PTX and with PTX-loaded macromolecular carriers from our previous study, this multi-small molecule-conjugated strategy improved the water solubility, loading rate, targeting ability, antitumor activity, and toxicity profile of PTX. These results support the use of multi-small molecules as tumor-targeting drug delivery systems. Keywords: multi-small molecules, paclitaxel, prodrugs, targeting, tumor therapy

NMR approaches in structure-based lead discovery: recent developments and new frontiers for targeting multi-protein complexes.

Science.gov (United States)

Dias, David M; Ciulli, Alessio

2014-01-01

Nuclear magnetic resonance (NMR) spectroscopy is a pivotal method for structure-based and fragment-based lead discovery because it is one of the most robust techniques to provide information on protein structure, dynamics and interaction at an atomic level in solution. Nowadays, in most ligand screening cascades, NMR-based methods are applied to identify and structurally validate small molecule binding. These can be high-throughput and are often used synergistically with other biophysical assays. Here, we describe current state-of-the-art in the portfolio of available NMR-based experiments that are used to aid early-stage lead discovery. We then focus on multi-protein complexes as targets and how NMR spectroscopy allows studying of interactions within the high molecular weight assemblies that make up a vast fraction of the yet untargeted proteome. Finally, we give our perspective on how currently available methods could build an improved strategy for drug discovery against such challenging targets. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

A modified high-intensity Cs sputter negative-ion source with multi-target mechanism

International Nuclear Information System (INIS)

Si Houzhi; Zhang Weizhong; Zhu Jinhau; Du Guangtian; Zhang Tiaorong; Gao Xiang

1993-01-01

The source is based on Middleton's high-intensity mode, but modified to a multi-target version. It is equipped with a spherical molybdenum ionizer, a 20-position target wheel and a vacuum lock for loading and unloading sample batches. A metal-ceramic bonded section protected by a specially designed labyrinth shielding system results in reliable insulation of the cathode and convenient control of cesium vapor. The latter is particularly important when an oversupply of cesium occurs. The source was developed for accelerator mass spectrometry (AMS) applications. Recently, three versions based on the prototype of the source have been successfully tested to meet different requirements: (a) Single target version, (b) multi-target version with manual sample change, and (c) multi-target version with remote control sample change. Some details of the technical and operational characteristics are presented. (orig.)

Construction, completion, and testing of replacement monitoring wells MW 3-2, MW 6-2, MW 7-2, and MW 11-2, Mountain Home Air Force Base, Idaho, February through April 2000

Science.gov (United States)

Parliman, D.J.

2000-01-01

In February and March 2000, the U.S. Geological Survey Western Regional Research Drilling Operation constructed replacement monitoring wells MW 3–2, MW 6–2, MW 7–2, and MW 11–2 as part of a regional ground-water monitor- ing network for the Mountain Home Air Force Base, Elmore County, Idaho. Total well depths ranged from 435.5 to 456.5 feet, and initial depth-to-water measurements ranged from about 350 to 375 feet below land surface. After completion, wells were pumped and onsite measurements were made of water temperature, specific conductance, pH, and dissolved oxygen. At each well, natural gamma, spontaneous potential, resistivity, caliper, and temperature logs were obtained from instruments placed in open boreholes. A three- dimensional borehole flow analysis was completed for MW 3–2 and MW 11–2, and a video log was obtained for MW 11–2 to annotate lithology and note wet zones in the borehole above saturated rock.

VAGUE: a graphical user interface for the Velvet assembler.

Science.gov (United States)

Powell, David R; Seemann, Torsten

2013-01-15

Velvet is a popular open-source de novo genome assembly software tool, which is run from the Unix command line. Most of the problems experienced by new users of Velvet revolve around constructing syntactically and semantically correct command lines, getting input files into acceptable formats and assessing the output. Here, we present Velvet Assembler Graphical User Environment (VAGUE), a multi-platform graphical front-end for Velvet. VAGUE aims to make sequence assembly accessible to a wider audience and to facilitate better usage amongst existing users of Velvet. VAGUE is implemented in JRuby and targets the Java Virtual Machine. It is available under an open-source GPLv2 licence from http://www.vicbioinformatics.com/. torsten.seemann@monash.edu.

Benchmark of physics design of a proposed 30 MW Multi Purpose Research Reactor using a Monte Carlo code MCNP

International Nuclear Information System (INIS)

Singh, Tej; Kumar, Jainendra; Sharma, Archana; Singh, Kanchhi; Raina, V.K.; Srinivasan, P.

2009-01-01

At present Dhruva and Cirus reactors provide majority of research reactor based experimental/irradiation facilities to cater to various needs of the vast pool of researchers in the field of sciences research and development work for nuclear power plants and production of radioisotopes. With a view to further consolidate and expand the scope of research and development in nuclear and allied sciences, a new 30 MWt Multi Purpose Research Reactor is proposed to be constructed. This paper describes some of the physics design features of this reactor using MCNP code to validate the deterministic methods. The criticality calculations for 100 material testing reactor (JHR) of France and 610 MW SAVANNAH thermal reactor were performed using MCNP computer codes to boost the confidence level in designing the physics design of reactor core. (author)

Mapsembler, targeted and micro assembly of large NGS datasets on a desktop computer

Directory of Open Access Journals (Sweden)

Peterlongo Pierre

2012-03-01

Full Text Available Abstract Background The analysis of next-generation sequencing data from large genomes is a timely research topic. Sequencers are producing billions of short sequence fragments from newly sequenced organisms. Computational methods for reconstructing whole genomes/transcriptomes (de novo assemblers are typically employed to process such data. However, these methods require large memory resources and computation time. Many basic biological questions could be answered targeting specific information in the reads, thus avoiding complete assembly. Results We present Mapsembler, an iterative micro and targeted assembler which processes large datasets of reads on commodity hardware. Mapsembler checks for the presence of given regions of interest that can be constructed from reads and builds a short assembly around it, either as a plain sequence or as a graph, showing contextual structure. We introduce new algorithms to retrieve approximate occurrences of a sequence from reads and construct an extension graph. Among other results presented in this paper, Mapsembler enabled to retrieve previously described human breast cancer candidate fusion genes, and to detect new ones not previously known. Conclusions Mapsembler is the first software that enables de novo discovery around a region of interest of repeats, SNPs, exon skipping, gene fusion, as well as other structural events, directly from raw sequencing reads. As indexing is localized, the memory footprint of Mapsembler is negligible. Mapsembler is released under the CeCILL license and can be freely downloaded from http://alcovna.genouest.org/mapsembler/.

Power Electronic System for Multi-MW PV sites

DEFF Research Database (Denmark)

Paasch, Kasper

in Sønderborg (DK) was implemented. A total of 17 PV-inverters have been monitored during a period exceeding one year and the recorded data constitutes the basis of this investigation. A part of the 2.1 MW PV plant was reconfigured to emulate the behavior of a central-inverter and solar panels distributed over...... a distance of 160 m. In parallel a string based inverter configuration was established with solar panels at the same locations. An analysis of irradiation data recorded during the test period showed that non-uniform irradiance due to moving clouds is expected to influence the PV plants for less than 4.......4%. A portable IV-scanning instrument for the fast long term characterization of solar panels was developed as part of the project. Each second a sweep of the IV-characteristics of a solar panel is performed and the result stored for later analysis. The instrument is based on an active load, is optimized...

Earthquake cycle modeling of multi-segmented faults: dynamic rupture and ground motion simulation of the 1992 Mw 7.3 Landers earthquake.

Science.gov (United States)

Petukhin, A.; Galvez, P.; Somerville, P.; Ampuero, J. P.

2017-12-01

We perform earthquake cycle simulations to study the characteristics of source scaling relations and strong ground motions and in multi-segmented fault ruptures. For earthquake cycle modeling, a quasi-dynamic solver (QDYN, Luo et al, 2016) is used to nucleate events and the fully dynamic solver (SPECFEM3D, Galvez et al., 2014, 2016) is used to simulate earthquake ruptures. The Mw 7.3 Landers earthquake has been chosen as a target earthquake to validate our methodology. The SCEC fault geometry for the three-segmented Landers rupture is included and extended at both ends to a total length of 200 km. We followed the 2-D spatial correlated Dc distributions based on Hillers et. al. (2007) that associates Dc distribution with different degrees of fault maturity. The fault maturity is related to the variability of Dc on a microscopic scale. Large variations of Dc represents immature faults and lower variations of Dc represents mature faults. Moreover we impose a taper (a-b) at the fault edges and limit the fault depth to 15 km. Using these settings, earthquake cycle simulations are performed to nucleate seismic events on different sections of the fault, and dynamic rupture modeling is used to propagate the ruptures. The fault segmentation brings complexity into the rupture process. For instance, the change of strike between fault segments enhances strong variations of stress. In fact, Oglesby and Mai (2012) show the normal stress varies from positive (clamping) to negative (unclamping) between fault segments, which leads to favorable or unfavorable conditions for rupture growth. To replicate these complexities and the effect of fault segmentation in the rupture process, we perform earthquake cycles with dynamic rupture modeling and generate events similar to the Mw 7.3 Landers earthquake. We extract the asperities of these events and analyze the scaling relations between rupture area, average slip and combined area of asperities versus moment magnitude. Finally, the

Disulfide-induced self-assembled targets: A novel strategy for the label free colorimetric detection of DNAs/RNAs via unmodified gold nanoparticles

Science.gov (United States)

Shokri, Ehsan; Hosseini, Morteza; Davari, Mehdi D.; Ganjali, Mohammad R.; Peppelenbosch, Maikel P.; Rezaee, Farhad

2017-04-01

A modified non-cross-linking gold-nanoparticles (Au-NPs) aggregation strategy has been developed for the label free colorimetric detection of DNAs/RNAs based on self-assembling target species in the presence of thiolated probes. Two complementary thiol- modified probes, each of which specifically binds at one half of the target introduced SH groups at both ends of dsDNA. Continuous disulfide bond formation at 3‧ and 5‧ terminals of targets leads to the self-assembly of dsDNAs into the sulfur- rich and flexible products with different lengths. These products have a high affinity for the surface of Au-NPs and efficiently protect the surface from salt induced aggregation. To evaluate the assay efficacy, a small part of the citrus tristeza virus (CTV) genome was targeted, leading to a detection limit of about 5 × 10-9 mol.L-1 over a linear ranged from 20 × 10-9 to 10 × 10-7 mol.L-1. This approach also exhibits good reproducibility and recovery levels in the presence of plant total RNA or human plasma total circulating RNA extracts. Self-assembled targets can be then sensitively distinguished from non-assembled or mismatched targets after gel electrophoresis. The disulfide reaction method and integrating self-assembled DNAs/RNAs targets with bare AuNPs as a sensitive indicator provide us a powerful and simple visual detection tool for a wide range of applications.

Effective source size, yield and beam profile from multi-layered bremsstrahlung targets

International Nuclear Information System (INIS)

Svensson, R.; Brahme, A.

1996-01-01

Modern conformal radiotherapy benefits from heterogeneous dose delivery using scanned narrow bremsstrahlung beams of high energy in combination with dynamic double focused multi-leaf collimation and purging magnets. When using a purging magnet to remove electrons and positrons the target space is limited and unorthodox thin multi-layered targets are needed. A computational technique has therefore been developed to determine the forward yield and the angular distributions of the bremsstrahlung beam as well as the size and location of the effective and the virtual photon point source for arbitrary multi-layer bremsstrahlung targets. The Gaussian approximation of the diffusion equation for the electrons has been used and convolved with the bremsstrahlung production process. For electrons with arbitrary emittance impinging on targets of any multi-layer and atomic number combination, the model is well applicable, at least for energies in the range 1-100 MeV. The intrinsic bremsstrahlung photon profile has been determined accurately by deconvolving the electron multiple scattering process from thin experimental beryllium target profiles. For electron pencil beams incident on a target of high density and atomic number such as tungsten, the size of the effective photon source stays at around a tenth of a millimetre. The effective photon source for low-Z materials such as Be, C and Al is located at depths from 3-7 mm in the target, decreasing with increasing atomic number. The effective photon source at off-axis positions then moves out considerably from the central axis, which should be considered when aligning collimators. For high-Z materials such as tungsten, the location of the effective photon source is at a few tenths of a millimetre deep. The virtual photon point source is located only a few tenths of a millimetre upstream of the effective photon source both for high- and low-Z materials. For 50 MeV electrons incident on multi-layered full range targets the radial

Two-phase framework for optimal multi-target Lambert rendezvous

OpenAIRE

Bang, Jun; Ahn, Jaemyung

2017-01-01

This paper proposes a two-phase framework to solve an optimal multi-target Lambert rendezvous problem. The first phase solves a series of single-target rendezvous problems for all departure-arrival object pairs to generate the elementary solutions, which provides candidate rendezvous trajectories (elementary solutions). The second phase formulates a variant of traveling salesman problem (TSP) using the elementary solutions prepared in the first phase and determines the best rendezvous sequenc...

Cellular imaging by targeted assembly of hot-spot SERS and photoacoustic nanoprobes using split-fluorescent protein scaffolds.

Science.gov (United States)

Köker, Tuğba; Tang, Nathalie; Tian, Chao; Zhang, Wei; Wang, Xueding; Martel, Richard; Pinaud, Fabien

2018-02-09

The in cellulo assembly of plasmonic nanomaterials into photo-responsive probes is of great interest for many bioimaging and nanophotonic applications but remains challenging with traditional nucleic acid scaffolds-based bottom-up methods. Here, we address this quandary using split-fluorescent protein (FP) fragments as molecular glue and switchable Raman reporters to assemble gold or silver plasmonic nanoparticles (NPs) into photonic clusters directly in live cells. When targeted to diffusing surface biomarkers in cancer cells, the NPs self-assemble into surface-enhanced Raman-scattering (SERS) nanoclusters having hot spots homogenously seeded by the reconstruction of full-length FPs. Within plasmonic hot spots, autocatalytic activation of the FP chromophore and near-field amplification of its Raman fingerprints enable selective and sensitive SERS imaging of targeted cells. This FP-driven assembly of metal colloids also yields enhanced photoacoustic signals, allowing the hybrid FP/NP nanoclusters to serve as contrast agents for multimodal SERS and photoacoustic microscopy with single-cell sensitivity.

Hierarchical self-assembly of magnetic nanoclusters for theranostics: Tunable size, enhanced magnetic resonance imagability, and controlled and targeted drug delivery.

Science.gov (United States)

Nguyen, Dai Hai; Lee, Jung Seok; Choi, Jong Hoon; Park, Kyung Min; Lee, Yunki; Park, Ki Dong

2016-04-15

Nanoparticle-based imaging and therapy are of interest for theranostic nanomedicine. In particular, superparamagnetic iron oxide (SPIO) nanoparticles (NPs) have attracted much attention in cancer imaging, diagnostics, and treatment because of their superior imagability and biocompatibility (approved by the Food and Drug Administration). Here, we developed SPIO nanoparticles (NPs) that self-assembled into magnetic nanoclusters (SAMNs) in aqueous environments as a theranostic nano-system. To generate multi-functional SPIO NPs, we covalently conjugated β-cyclodextrin (β-CD) to SPIO NPs using metal-adhesive dopamine groups. Polyethylene glycol (PEG) and paclitaxel (PTX) were hosted in the β-CD cavity through high affinity complexation. The core-shell structure of the magnetic nanoclusters was elucidated based on the condensed SPIO core and a PEG shell using electron microscopy and the composition was analyzed by thermogravimetric analysis (TGA). Our results indicate that nanocluster size could be readily controlled by changing the SPIO/PEG ratio in the assemblies. Interestingly, we observed a significant enhancement in magnetic resonance contrast due to the large cluster size and dense iron oxide core. In addition, tethering a tumor-targeting peptide to the SAMNs enhanced their uptake into tumor cells. PTX was efficiently loaded into β-CDs and released in a controlled manner when exposed to competitive guest molecules. These results strongly indicate that the SAMNs developed in this study possess great potential for application in image-guided cancer chemotherapy. In this study, we developed multi-functional SPIO NPs that self-assembled into magnetic nanoclusters (SAMNs) in aqueous conditions as a theranostic nano-system. The beta-cyclodextrin (β-CD) was immobilized on the surfaces of SPIO NPs and RGD-conjugated polyethylene glycol (PEG) and paclitaxel (PTX) were hosted in the β-CD cavity through high affinity complexation. We found that nanocluster size could be

Cooperative multi-robot observation of multiple moving targets

International Nuclear Information System (INIS)

Parker, L.E.; Emmons, B.A.

1997-01-01

An important issue that arises in the automation of many security, surveillance, and reconnaissance tasks is that of monitoring, or observing, the movements of targets navigating in a bounded area of interest. A key research issue in these problems is that of sensor placement--determining where sensors should be located to maintain the targets in view. In complex applications of this type, the use of multiple sensors dynamically moving over time is required. In this paper, the authors investigate the sue of a cooperative team of autonomous sensor-based robots for multi-robot observation of multiple moving targets. They focus primarily on developing the distributed control strategies that allow the robot team to attempt to maximize the collective tie during which each object is being observed by at least one robot in the area of interest. The initial efforts in this problem address the aspects of distributed control in homogeneous robot teams with equivalent sensing and movement capabilities working in an uncluttered, bounded area. This paper first formalizes the problem, discusses related work, and then shows that this problem is NP-hard. They then present a distributed approximate approach to solving this problem that combines low-level multi-robot control with higher-level control

Low-communication parallel quantum multi-target preimage search

NARCIS (Netherlands)

Banegas, G.S.; Bernstein, D.J.; Adams, Carlisle; Camenisch, Jan

2017-01-01

The most important pre-quantum threat to AES-128 is the 1994 van Oorschot–Wiener “parallel rho method”, a low-communication parallel pre-quantum multi-target preimage-search algorithm. This algorithm uses a mesh of p small processors, each running for approximately 2 128 /pt 2128/pt fast steps, to

Multi-technology control centre to integrate 460 MW renewables

International Nuclear Information System (INIS)

2016-01-01

The new RWE Innogy Aersa Control Centre that has been certified to act as an interface with CECRE (the Renewable Energy Control Centre) since February 2015, connects RWE’s 20 renewable energy facilities with REE, the Spanish Electricity Grid. As a result, it ensures that wind farms, in addition to hydropower and solar plants, can inject the energy generated by its 460 MW installed safely and with no penalties. Green Eagle Solutions, a provider of software solutions for renewable energy companies, has collaborated with RWE in the development of this Control Centre, meeting the high standards of quality and safety required by RWE. This centre uses CompactSCADA® technology to integrate power generation facilities that need to be integrated in a Control Centre to communicate with REE’s CECRE. (Author)

Multi-target electrochemical biosensing enabled by integrated CMOS electronics

International Nuclear Information System (INIS)

Rothe, J; Lewandowska, M K; Heer, F; Frey, O; Hierlemann, A

2011-01-01

An integrated electrochemical measurement system, based on CMOS technology, is presented, which allows the detection of several analytes in parallel (multi-analyte) and enables simultaneous monitoring at different locations (multi-site). The system comprises a 576-electrode CMOS sensor chip, an FPGA module for chip control and data processing, and the measurement laptop. The advantages of the highly versatile system are demonstrated by two applications. First, a label-free, hybridization-based DNA sensor is enabled by the possibility of large-scale integration in CMOS technology. Second, the detection of the neurotransmitter choline is presented by assembling the chip with biosensor microprobe arrays. The low noise level enables a limit of detection of, e.g., 0.3 µM choline. The fully integrated system is self-contained: it features cleaning, functionalization and measurement functions without the need for additional electrical equipment. With the power supplied by the laptop, the system is very suitable for on-site measurements

Preliminary Design of a Multi-Column TLP Foundation for a 5-MW Offshore Wind Turbine

Directory of Open Access Journals (Sweden)

Yanping He

2012-10-01

Full Text Available Currently, floating wind turbines (FWTs may be the more economical and suitable systems with which to exploit offshore wind energy in deep waters. Among the various types of floating foundations for offshore wind farms, a tension leg platform (TLP foundation can provide a relatively stable platform for currently available offshore wind turbines without requiring major modifications. In this study, a new multi-column TLP foundation (WindStar TLP was developed for the NREL 5-MW offshore wind turbine according to site-specific environmental conditions, which are the same as the OC3-Hywind (NREL conditions. The general arrangement, main structure and mooring system were also designed and investigated through hydrodynamic and natural frequency analyses. The complete system avoids resonance through the rotor excitations. An aero-hydro-servo-elastic coupled analysis was carried out in the time domain with the numerical tool FAST. Statistics of the key parameters were obtained and analysed and comparisons to MIT/NREL TLP are made. As a result, the design requirements were shown to be satisfied, and the proposed WindStar TLP was shown to have favourable motion characteristics under extreme wind and wave conditions with a lighter and smaller structure. The new concept holds great potential for further development.

Multi-Target Tracking via Mixed Integer Optimization

Science.gov (United States)

2016-05-13

an easily interpretable global objective function. Furthermore, we propose a greedy heuristic which quickly finds good solutions. We extend both the... heuristic and the MIO model to scenarios with missed detections and false alarms. Index Terms—optimization; multi-target tracking; data asso- ciation...energy in [14] and then again as a minimization of discrete-continuous energy in [15]. These algorithms aim to more accurately represent the nature of the

Multifractal analysis of 2001 Mw 7 . 7 Bhuj earthquake sequence in Gujarat, Western India

Science.gov (United States)

Aggarwal, Sandeep Kumar; Pastén, Denisse; Khan, Prosanta Kumar

2017-12-01

The 2001 Mw 7 . 7 Bhuj mainshock seismic sequence in the Kachchh area, occurring during 2001 to 2012, has been analyzed using mono-fractal and multi-fractal dimension spectrum analysis technique. This region was characterized by frequent moderate shocks of Mw ≥ 5 . 0 for more than a decade since the occurrence of 2001 Bhuj earthquake. The present study is therefore important for precursory analysis using this sequence. The selected long-sequence has been investigated first time for completeness magnitude Mc 3.0 using the maximum curvature method. Multi-fractal Dq spectrum (Dq ∼ q) analysis was carried out using effective window-length of 200 earthquakes with a moving window of 20 events overlapped by 180 events. The robustness of the analysis has been tested by considering the magnitude completeness correction term of 0.2 to Mc 3.0 as Mc 3.2 and we have tested the error in the calculus of Dq for each magnitude threshold. On the other hand, the stability of the analysis has been investigated down to the minimum magnitude of Mw ≥ 2 . 6 in the sequence. The analysis shows the multi-fractal dimension spectrum Dq decreases with increasing of clustering of events with time before a moderate magnitude earthquake in the sequence, which alternatively accounts for non-randomness in the spatial distribution of epicenters and its self-organized criticality. Similar behavior is ubiquitous elsewhere around the globe, and warns for proximity of a damaging seismic event in an area. OS: Please confirm math roman or italics in abs.

Eurisol-DS Multi-MW target A proposal for improving overall performance in relation to the isotope yield

CERN Document Server

Samec, K; Kadi, Yacine; Rocca, Roberto; Kharoua, Cyril

2008-01-01

The Eurisol Design Study has been initiated by the European Commission to demonstrate the feasibility of a facility for producing large yields of exotic isotopes. At the core of the projected facility, the neutron source produces spallation neutrons from a proton beam impacting dense liquid metal. The neutrons emitted from the source are used to fission Uranium targets which, in turn, produce high yields of isotopes. This technical report summarises efforts to improve the overall performance of the planned facility, by optimising the neutron source and the disposition of the fission targets.

EURISOL-DS Multi-MW Target. A proposal for improving overall performance in relation to the isotope yield

CERN Document Server

Karel Samec, Mats Lindroos, Yacine Kadi,Roberto Rocca, Cyril KharouaAB Dept. ATB

The Eurisol Design Study has been initiated by the European Commission to demonstratethe feasibility of a facility for producing large yields of exotic isotopes.At the core of the projected facility, the neutron source produces spallation neutrons from aproton beam impacting dense liquid metal. The neutrons emitted from the source are usedto fission Uranium targets which, in turn, produce high yields of isotopes.This technical report summarises efforts to improve the overall performance of the plannedfacility, by optimising the neutron source and the disposition of the fission targets.

Identification and characterization of carprofen as a multi-target FAAH/COX inhibitor

Science.gov (United States)

Favia, Angelo D.; Habrant, Damien; Scarpelli, Rita; Migliore, Marco; Albani, Clara; Bertozzi, Sine Mandrup; Dionisi, Mauro; Tarozzo, Glauco; Piomelli, Daniele; Cavalli, Andrea; De Vivo, Marco

2013-01-01

Pain and inflammation are major therapeutic areas for drug discovery. Current drugs for these pathologies have limited efficacy, however, and often cause a number of unwanted side effects. In the present study, we identify the non-steroid anti-inflammatory drug, carprofen, as a multi-target-directed ligand that simultaneously inhibits cyclooxygenase-1 (COX-1), COX-2 and fatty acid amide hydrolase (FAAH). Additionally, we synthesized and tested several racemic derivatives of carprofen, sharing this multi-target activity. This may result in improved analgesic efficacy and reduced side effects (Naidu, et al (2009) J Pharmacol Exp Ther 329, 48-56; Fowler, C.J. et al. (2012) J Enzym Inhib Med Chem Jan 6; Sasso, et al (2012) Pharmacol Res 65, 553). The new compounds are among the most potent multi-target FAAH/COXs inhibitors reported so far in the literature, and thus may represent promising starting points for the discovery of new analgesic and anti-inflammatory drugs. PMID:23043222

Aeroelastic simulation of multi-MW wind turbines using a free vortex model coupled to a geometrically exact beam model

International Nuclear Information System (INIS)

Saverin, Joseph; Peukert, Juliane; Marten, David; Pechlivanoglou, George; Paschereit, Christian Oliver; Greenblatt, David

2016-01-01

The current paper investigates the aeroelastic modelling of large, flexible multi- MW wind turbine blades. Most current performance prediction tools make use of the Blade Element Momentum (BEM) model, based upon a number of simplifying assumptions that hold only under steady conditions. This is why a lifting line free vortex wake (LLFVW) algorithm is used here to accurately resolve unsteady wind turbine aerodynamics. A coupling to the structural analysis tool BeamDyn, based on geometrically exact beam theory, allows for time-resolved aeroelastic simulations with highly deflected blades including bend-twist, coupling. Predictions of blade loading and deformation for rigid and flexible blades are analysed with reference to different aerodynamic and structural approaches. The emergency shutdown procedure is chosen as an examplary design load case causing large deflections to place emphasis on the influence of structural coupling and demonstrate the necessity of high fidelity structural models. (paper)

Polymer Directed Protein Assemblies

NARCIS (Netherlands)

van Rijn, Patrick

2013-01-01

Protein aggregation and protein self-assembly is an important occurrence in natural systems, and is in some form or other dictated by biopolymers. Very obvious influences of biopolymers on protein assemblies are, e. g., virus particles. Viruses are a multi-protein assembly of which the morphology is

Aeroelastic Optimization of a 10 MW Wind Turbine Blade with Active Trailing Edge Flaps

DEFF Research Database (Denmark)

Barlas, Athanasios; Tibaldi, Carlo; Zahle, Frederik

2016-01-01

This article presents the aeroelastic optimization of a 10MW wind turbine ‘smart blade’ equipped with active trailing edge flaps. The multi-disciplinary wind turbine analysis and optimization tool HawtOpt2 is utilized, which is based on the open-source framework Open-MDAO. The tool interfaces...... to several state-of-the art simulation codes, allowing for a wide variety of problem formulations and combinations of models. A simultaneous aerodynamic and structural optimization of a 10 MW wind turbine rotor is carried out with respect to material layups and outer shape. Active trailing edge flaps...

Viral capsid assembly as a model for protein aggregation diseases: Active processes catalyzed by cellular assembly machines comprising novel drug targets.

Science.gov (United States)

Marreiros, Rita; Müller-Schiffmann, Andreas; Bader, Verian; Selvarajah, Suganya; Dey, Debendranath; Lingappa, Vishwanath R; Korth, Carsten

2015-09-02

therapeutics. A key basis for the commonality between viral and neurodegenerative disease aggregation is a broader definition of assembly as more than just simple aggregation, particularly suited for the crowded cytoplasm. The assembly machines are collections of proteins that catalytically accelerate an assembly reaction that would occur spontaneously but too slowly to be relevant in vivo. Being an enzyme complex with a functional allosteric site, appropriated for a non-physiological purpose (e.g. viral infection or conformational disease), these assembly machines present a superior pharmacological target because inhibition of their active site will amplify an effect on their substrate reaction. Here, we present this hypothesis based on recent proof-of-principle studies against Aβ assembly relevant in Alzheimer's disease. Copyright © 2014 Elsevier B.V. All rights reserved.

Multi-MW accelerator target material properties under proton irradiation at Brookhaven National Laboratory linear isotope producer

Science.gov (United States)

Simos, N.; Ludewig, H.; Kirk, H.; Dooryhee, E.; Ghose, S.; Zhong, Z.; Zhong, H.; Makimura, S.; Yoshimura, K.; Bennett, J. R. J.; Kotsinas, G.; Kotsina, Z.; McDonald, K. T.

2018-05-01

The effects of proton beams irradiating materials considered for targets in high-power accelerator experiments have been studied using the Brookhaven National Laboratory's (BNL) 200 MeV proton linac. A wide array of materials and alloys covering a wide range of the atomic number (Z) are being scoped by the high-power accelerator community prompting the BNL studies to focus on materials representing each distinct range, i.e. low-Z, mid-Z and high-Z. The low range includes materials such as beryllium and graphite, the midrange alloys such as Ti-6Al-4V, gum metal and super-Invar and finally the high-Z range pure tungsten and tantalum. Of interest in assessing proton irradiation effects are (a) changes in physiomechanical properties which are important in maintaining high-power target functionality, (b) identification of possible limits of proton flux or fluence above which certain materials cease to maintain integrity, (c) the role of material operating temperature in inducing or maintaining radiation damage reversal, and (d) phase stability and microstructural changes. The paper presents excerpt results deduced from macroscopic and microscopic post-irradiation evaluation (PIE) following several irradiation campaigns conducted at the BNL 200 MeV linac and specifically at the isotope producer beam-line/target station. The microscopic PIE relied on high energy x-ray diffraction at the BNL NSLS X17B1 and NSLS II XPD beam lines. The studies reveal the dramatic effects of irradiation on phase stability in several of the materials, changes in physical properties and ductility loss as well as thermally induced radiation damage reversal in graphite and alloys such as super-Invar.

Beyond assemblies: system convergence and multi-materiality.

Science.gov (United States)

Wiscombe, Tom

2012-03-01

The architectural construction industry has become increasingly more specialized over the past 50 years, creating a culture of layer thinking over part-to-whole thinking. Building systems and technologies are often cobbled together in conflicting and uncorrelated ways, even when referred to as 'integrated', such as by way of building information modeling. True integration of building systems requires rethinking how systems and architectural morphologies can push and pull on one another, creating not only innovation in technology but in aesthetics. The revolution in composite materials, with unprecedented plasticity and performance features, opens up a huge range of possibilities for achieving this kind of convergence. Composites by nature fuse envelope and structure, but through various types of inflections, they can also be made to conduct air and fluids through cavities and de-laminations, as well as integrate lighting and energy systems. Assembly as we know it moves away from mineral materials and hardware and toward polymers and 'healing'. Further, when projected into the near-future realm of multi-materiality and 3D manufacturing, possibilities for embedding systems and creating gradients of rigidity and opacity open up, pointing to an entirely new realm of architectural thinking.

Beyond assemblies: system convergence and multi-materiality

International Nuclear Information System (INIS)

Wiscombe, Tom

2012-01-01

The architectural construction industry has become increasingly more specialized over the past 50 years, creating a culture of layer thinking over part-to-whole thinking. Building systems and technologies are often cobbled together in conflicting and uncorrelated ways, even when referred to as 'integrated', such as by way of building information modeling. True integration of building systems requires rethinking how systems and architectural morphologies can push and pull on one another, creating not only innovation in technology but in aesthetics. The revolution in composite materials, with unprecedented plasticity and performance features, opens up a huge range of possibilities for achieving this kind of convergence. Composites by nature fuse envelope and structure, but through various types of inflections, they can also be made to conduct air and fluids through cavities and de-laminations, as well as integrate lighting and energy systems. Assembly as we know it moves away from mineral materials and hardware and toward polymers and 'healing'. Further, when projected into the near-future realm of multi-materiality and 3D manufacturing, possibilities for embedding systems and creating gradients of rigidity and opacity open up, pointing to an entirely new realm of architectural thinking.

The formation and assembly history of the Milky Way revealed by its globular cluster population

Science.gov (United States)

Kruijssen, J. M. Diederik; Pfeffer, Joel L.; Reina-Campos, Marta; Crain, Robert A.; Bastian, Nate

2018-06-01

We use the age-metallicity distribution of 96 Galactic globular clusters (GCs) to infer the formation and assembly history of the Milky Way (MW), culminating in the reconstruction of its merger tree. Based on a quantitative comparison of the Galactic GC population to the 25 cosmological zoom-in simulations of MW-mass galaxies in the E-MOSAICS project, which self-consistently model the formation and evolution of GC populations in a cosmological context, we find that the MW assembled quickly for its mass, reaching {25, 50}% of its present-day halo mass already at z = {3, 1.5} and half of its present-day stellar mass at z = 1.2. We reconstruct the MW's merger tree from its GC age-metallicity distribution, inferring the number of mergers as a function of mass ratio and redshift. These statistics place the MW's assembly rate among the 72th-94th percentile of the E-MOSAICS galaxies, whereas its integrated properties (e.g. number of mergers, halo concentration) match the median of the simulations. We conclude that the MW has experienced no major mergers (mass ratios >1:4) since z ˜ 4, sharpening previous limits of z ˜ 2. We identify three massive satellite progenitors and constrain their mass growth and enrichment histories. Two are proposed to correspond to Sagittarius (few 108M⊙) and Canis Major (˜109 M⊙). The third satellite has no known associated relic and was likely accreted between z = 0.6-1.3. We name this enigmatic galaxy Kraken and propose that it is the most massive satellite (M* ˜ 2 × 109 M⊙) ever accreted by the MW. We predict that ˜40% of the Galactic GCs formed ex-situ (in galaxies with masses M* = 2 × 107-2 × 109 M⊙), with 6 ± 1 being former nuclear clusters.

Heavy water jet target and a beryllium target for production of fast neutrons

International Nuclear Information System (INIS)

Logan, C.M.; Anderson, J.D.; Barschall, H.H.; Davis, J.C.

1975-01-01

A limitation on the neutron flux obtainable from proton or deuteron induced reactions is the heating of the target by the accelerated charged particles. The heat can be removed more easily if the target moves. The possibility of using a rotating Be target and a heavy water jet as a target for bombardment by 35-MeV deuterons was studied. In a thick Be metal target moving at 10 m/sec through such a beam of 1 cm diameter a temperature pulse of about 300 0 C will be produced by the 0.3 MW beam. The Be target should be able to withstand such a temperature pulse. A Be target suitable for 3 MW of power in a 1 cm diameter beam would require internal cooling and a higher velocity. A free jet of heavy water is also a possible target. Laser photographs of water jets in vacuum show small angles of divergence. The effect of heating by a 0.3 MW beam is probably not important because the temperature rise produced by the beam is small compared to the absolute temperature of the unheated jet. (auth)

Modular assembly of transposable element arrays by microsatellite targeting in the guayule and rice genomes.

Science.gov (United States)

Valdes Franco, José A; Wang, Yi; Huo, Naxin; Ponciano, Grisel; Colvin, Howard A; McMahan, Colleen M; Gu, Yong Q; Belknap, William R

2018-04-19

Guayule (Parthenium argentatum A. Gray) is a rubber-producing desert shrub native to Mexico and the United States. Guayule represents an alternative to Hevea brasiliensis as a source for commercial natural rubber. The efficient application of modern molecular/genetic tools to guayule improvement requires characterization of its genome. The 1.6 Gb guayule genome was sequenced, assembled and annotated. The final 1.5 Gb assembly, while fragmented (N 50  = 22 kb), maps > 95% of the shotgun reads and is essentially complete. Approximately 40,000 transcribed, protein encoding genes were annotated on the assembly. Further characterization of this genome revealed 15 families of small, microsatellite-associated, transposable elements (TEs) with unexpected chromosomal distribution profiles. These SaTar (Satellite Targeted) elements, which are non-autonomous Mu-like elements (MULEs), were frequently observed in multimeric linear arrays of unrelated individual elements within which no individual element is interrupted by another. This uniformly non-nested TE multimer architecture has not been previously described in either eukaryotic or prokaryotic genomes. Five families of similarly distributed non-autonomous MULEs (microsatellite associated, modularly assembled) were characterized in the rice genome. Families of TEs with similar structures and distribution profiles were identified in sorghum and citrus. The sequencing and assembly of the guayule genome provides a foundation for application of current crop improvement technologies to this plant. In addition, characterization of this genome revealed SaTar elements with distribution profiles unique among TEs. Satar targeting appears based on an alternative MULE recombination mechanism with the potential to impact gene evolution.

Penetration of a Small Caliber Projectile into Single and Multi-layered Targets

Directory of Open Access Journals (Sweden)

Riad A.M.

2010-06-01

Full Text Available The normal penetration of armor-piercing projectiles into single and multi-layered steel plates has been investigated. An experimental program has been conducted to study the effect of spaced and in-contact layered targets on their ballistic resistance. Armor piercing projectiles with caliber of 7.62 mm were fired against a series of single and multi-layered steel targets. The projectile impact velocities were ranged from 300-600 m/s, whereas the total thicknesses of the tested single, spaced and in-contact layered steel targets were 3 mm. The penetration process of different tested target configurations has been simulated using Autodayn-2D hydrocode. The experimental measurements of the present work were used to discuss the effect of impact velocity, target configurations and number of layers of different spaced and in-contact layered steel targets on their ballistic resistance. In addition, the post-firing examination of the tested targets over the used impact velocity range showed that the single and each layer of spaced and in-contact laminated steel targets were failed by petalling. Finally, the obtained experimental measurements were compared with the corresponding numerical results of Autodyn-2D hydrocode, good agreement was generally obtained.

Dynamic Multi-Component Covalent Assembly for the Reversible Binding of Secondary Alcohols and Chirality Sensing

Science.gov (United States)

You, Lei; Berman, Jeffrey S.; Anslyn, Eric V.

2011-01-01

Reversible covalent bonding is often employed for the creation of novel supramolecular structures, multi-component assemblies, and sensing ensembles. In spite of remarkable success of dynamic covalent systems, the reversible binding of a mono-alcohol with high strength is challenging. Here we show that a strategy of carbonyl activation and hemiaminal ether stabilization can be embodied in a four-component reversible assembly that creates a tetradentate ligand and incorporates secondary alcohols with exceptionally high affinity. Evidence is presented that the intermediate leading to binding and exchange of alcohols is an iminium ion. Further, to demonstrate the use of this assembly process we explored chirality sensing and enantiomeric excess determinations. An induced twist in the ligand by a chiral mono-ol results in large Cotton effects in the circular dichroism spectra indicative of the alcohol’s handedness. The strategy revealed in this study should prove broadly applicable for the incorporation of alcohols into supramolecular architecture construction. PMID:22109274

Assembly of the novel five-component apicomplexan multi-aminoacyl-tRNA synthetase complex is driven by the hybrid scaffold protein Tg-p43.

Directory of Open Access Journals (Sweden)

Jason M van Rooyen

Full Text Available In Toxoplasma gondii, as in other eukaryotes, a subset of the amino-acyl-tRNA synthetases are arranged into an abundant cytoplasmic multi-aminoacyl-tRNA synthetase (MARS complex. Through a series of genetic pull-down assays, we have identified the enzymes of this complex as: methionyl-, glutaminyl-, glutamyl-, and tyrosyl-tRNA synthetases, and we show that the N-terminal GST-like domain of a partially disordered hybrid scaffold protein, Tg-p43, is sufficient for assembly of the intact complex. Our gel filtration studies revealed significant heterogeneity in the size and composition of isolated MARS complexes. By targeting the tyrosyl-tRNA synthetases subunit, which was found exclusively in the complete 1 MDa complex, we were able to directly visualize MARS particles in the electron microscope. Image analyses of the negative stain data revealed the observed heterogeneity and instability of these complexes to be driven by the intrinsic flexibility of the domain arrangements within the MARS complex. These studies provide unique insights into the assembly of these ubiquitous but poorly understood eukaryotic complexes.

Assessment of berberine as a multi-target antimicrobial: a multi-omics study for drug discovery and repositioning.

Science.gov (United States)

Karaosmanoglu, Kubra; Sayar, Nihat Alpagu; Kurnaz, Isil Aksan; Akbulut, Berna Sariyar

2014-01-01

Postgenomics drug development is undergoing major transformation in the age of multi-omics studies and drug repositioning. Rather than applications solely in personalized medicine, omics science thus additionally offers a better understanding of a broader range of drug targets and drug repositioning. Berberine is an isoquinoline alkaloid found in many medicinal plants. We report here a whole genome microarray study in tandem with proteomics techniques for mining the plethora of targets that are putatively involved in the antimicrobial activity of berberine against Escherichia coli. We found DNA replication/repair and transcription to be triggered by berberine, indicating that nucleic acids, in general, are among its targets. Our combined transcriptomics and proteomics multi-omics findings underscore that, in the presence of berberine, cell wall or cell membrane transport and motility-related functions are also specifically regulated. We further report a general decline in metabolism, as seen by repression of genes in carbohydrate and amino acid metabolism, energy production, and conversion. An involvement of multidrug efflux pumps, as well as reduced membrane permeability for developing resistance against berberine in E. coli was noted. Collectively, these findings offer original and significant leads for omics-guided drug discovery and future repositioning approaches in the postgenomics era, using berberine as a multi-omics case study.

Multi-targeted therapy for leprosy: insilico strategy to overcome multi drug resistance and to improve therapeutic efficacy.

Science.gov (United States)

Anusuya, Shanmugam; Natarajan, Jeyakumar

2012-12-01

Leprosy remains a major public health problem, since single and multi-drug resistance has been reported worldwide over the last two decades. In the present study, we report the novel multi-targeted therapy for leprosy to overcome multi drug resistance and to improve therapeutic efficacy. If multiple enzymes of an essential metabolic pathway of a bacterium were targeted, then the therapy would become more effective and can prevent the occurrence of drug resistance. The MurC, MurD, MurE and MurF enzymes of peptidoglycan biosynthetic pathway were selected for multi targeted therapy. The conserved or class specific active site residues important for function or stability were predicted using evolutionary trace analysis and site directed mutagenesis studies. Ten such residues which were present in at least any three of the four Mur enzymes (MurC, MurD, MurE and MurF) were identified. Among the ten residues G125, K126, T127 and G293 (numbered based on their position in MurC) were found to be conserved in all the four Mur enzymes of the entire bacterial kingdom. In addition K143, T144, T166, G168, H234 and Y329 (numbered based on their position in MurE) were significant in binding substrates and/co-factors needed for the functional events in any three of the Mur enzymes. These are the probable residues for designing newer anti-leprosy drugs in an attempt to reduce drug resistance. Copyright © 2012 Elsevier B.V. All rights reserved.

60-MW test using the 30-MW klystrons for the KEKB project

Science.gov (United States)

Fukuda, S.; Michizono, S.; Nakao, K.; Saito, Y.; Anami, S.

1995-07-01

The B-Factory is a future plan, requiring an energy upgrade of the KEK linac from 2.5 GeV to 8.0 GeV (KEKB Project). This paper describes the recent development of an S-band high-power pulse klystron to be used as the PF-linac rf-source of the B-Factory. This tube is a modified version of the existing 30-MW tube, which produces 51 MW at a 310 kV beam voltage by optimizing the focusing magnetic field. In order to increase the reliability, the cathode diameter, the gun housing, and the insulation ceramic-seal were enlarged. This tube was redesigned so as to have the same characteristics as the test results of 30-MW tubes at a higher applied voltage without changing the rf interaction region. Four prototype tubes have been manufactured; final test results showed that these new tubes produce an output power of more than 50 MW at 310 kV with an efficiency of 46%. Recently this tube has produced more than 60 MW at a 350 kV beam voltage for a demonstration test. A comparison between the FCI-code prediction and the test results is also given in this paper.

SAR Target Recognition Based on Multi-feature Multiple Representation Classifier Fusion

Directory of Open Access Journals (Sweden)

Zhang Xinzheng

2017-10-01

Full Text Available In this paper, we present a Synthetic Aperture Radar (SAR image target recognition algorithm based on multi-feature multiple representation learning classifier fusion. First, it extracts three features from the SAR images, namely principal component analysis, wavelet transform, and Two-Dimensional Slice Zernike Moments (2DSZM features. Second, we harness the sparse representation classifier and the cooperative representation classifier with the above-mentioned features to get six predictive labels. Finally, we adopt classifier fusion to obtain the final recognition decision. We researched three different classifier fusion algorithms in our experiments, and the results demonstrate thatusing Bayesian decision fusion gives thebest recognition performance. The method based on multi-feature multiple representation learning classifier fusion integrates the discrimination of multi-features and combines the sparse and cooperative representation classification performance to gain complementary advantages and to improve recognition accuracy. The experiments are based on the Moving and Stationary Target Acquisition and Recognition (MSTAR database,and they demonstrate the effectiveness of the proposed approach.

Multi-target drugs: the trend of drug research and development.

Science.gov (United States)

Lu, Jin-Jian; Pan, Wei; Hu, Yuan-Jia; Wang, Yi-Tao

2012-01-01

Summarizing the status of drugs in the market and examining the trend of drug research and development is important in drug discovery. In this study, we compared the drug targets and the market sales of the new molecular entities approved by the U.S. Food and Drug Administration from January 2000 to December 2009. Two networks, namely, the target-target and drug-drug networks, have been set up using the network analysis tools. The multi-target drugs have much more potential, as shown by the network visualization and the market trends. We discussed the possible reasons and proposed the rational strategies for drug research and development in the future.

Interpretation of the deep cracking phenomenon of tungsten monoblock targets observed in high-heat-flux fatigue tests at 20 MW/m"2

International Nuclear Information System (INIS)

Li, Muyuan; You, Jeong-Ha

2015-01-01

Highlights: • A theoretical interpretation is presented for deep crack of W monoblocks at 20 MW/m"2. • A consecutive process of crack initiation and growth was modeled in two stages. • The lifetime to crack initiation and the driving force of fracture are assessed. • Numerical predictions in this study agree well with the experimental findings. - Abstract: The HHF qualification tests conducted on the ITER divertor target prototypes showed that the tungsten monoblock armor suffered from deep cracking due to fatigue, when the applied high-heat-flux load approaches 20 MW/m"2. In spite of the critical implication of the deep cracking of armor on the structural integrity of a whole target component, no rigorous interpretation has been given to date. In this paper, a theoretical interpretation of the observed deep cracking feature is presented. A two-stage modeling approach is employed where deep cracking is thought to be a consecutive process of crack initiation and crack growth, which is assumed to be caused by plastic fatigue and brittle facture, respectively. The fatigue lifetime to crack initiation on the armor surface and the crack tip load of brittle fracture are assessed as a function of crack length and heat flux loads. The potential mechanisms of deep cracking are discussed for a typical slow transient high-heat-flux load cycle. It is shown that the quantitative predictions delivered in this study agree well with the observed findings offering insight into the nature of tungsten armor failure.

RISC assembly: Coordination between small RNAs and Argonaute proteins.

Science.gov (United States)

Kobayashi, Hotaka; Tomari, Yukihide

2016-01-01

Non-coding RNAs generally form ribonucleoprotein (RNP) complexes with their partner proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs, and PIWI-interacting RNAs, assemble with Argonaute (Ago) family proteins into the effector complex called RNA-induced silencing complex (RISC), which mediates sequence-specific target gene silencing. RISC assembly is not a simple binding between a small RNA and Ago; rather, it follows an ordered multi-step pathway that requires specific accessory factors. Some steps of RISC assembly and RISC-mediated gene silencing are dependent on or facilitated by particular intracellular platforms, suggesting their spatial regulation. In this review, we summarize the currently known mechanisms for RISC assembly of each small RNA class and propose a revised model for the role of the chaperone machinery in the duplex-initiated RISC assembly pathway. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa. Copyright © 2015 Elsevier B.V. All rights reserved.

JPRS Report, Science & Technology, Europe & Latin America, Argentina: Specifications of ARGOS 380 MW Reactor.

Science.gov (United States)

1988-02-18

and economy in operation. ENACE is an acronym for Empresa Nuclear Argentina de Centrales Electricas, or Argentine Nuclear Power Plant Corporation...products. The fuel transport system can be used during full reactor power operation to remove specially de - signed fuel assemblies containing rods for...SPECIFICATIONS OF ARGOS 380 MW REACTOR [Buenos Aires COMISION NACIONAL DE ENERGIA ATOMICA: INFORME in English 1987 pp 1-93] CONTENTS Argentine Offer of

Multi-scale ordering of self-assembled InAs/GaAs(001 quantum dots

Directory of Open Access Journals (Sweden)

Kiravittaya S

2006-01-01

Full Text Available AbstractOrdering phenomena related to the self-assembly of InAs quantum dots (QD grown on GaAs(001 substrates are experimentally investigated on different length scales. On the shortest length-scale studied here, we examine the QD morphology and observe two types of QD shapes, i.e., pyramids and domes. Pyramids are elongated along the 12345678910 directions and are bounded by {137} facets, while domes have a multi-facetted shape. By changing the growth rates, we are able to control the size and size homogeneity of freestanding QDs. QDs grown by using low growth rate are characterized by larger sizes and a narrower size distribution. The homogeneity of buried QDs is measured by photoluminescence spectroscopy and can be improved by low temperature overgrowth. The overgrowth induces the formation of nanostructures on the surface. The fabrication of self-assembled nanoholes, which are used as a template to induce short-range positioning of QDs, is also investigated. The growth of closely spaced QDs (QD molecules containing 2–6 QDs per QD molecule is discussed. Finally, the long-range positioning of self-assembled QDs, which can be achieved by the growth on patterned substrates, is demonstrated. Lateral QD replication observed during growth of three-dimensional QD crystals is reported.

A universal molecular translator for non-nucleic acid targets that enables dynamic DNA assemblies and logic operations.

Science.gov (United States)

Tang, Wei; Hu, Shichao; Wang, Huaming; Zhao, Yan; Li, Na; Liu, Feng

2014-11-28

A universal molecular translator based on the target-triggered DNA strand displacement was developed, which was able to convert various kinds of non-nucleic acid targets into a unique output DNA. This translation strategy was successfully applied in directing dynamic DNA assemblies and in realizing three-input logic gate operations.

Multi-objective optimization algorithms for mixed model assembly line balancing problem with parallel workstations

Directory of Open Access Journals (Sweden)

Masoud Rabbani

2016-12-01

Full Text Available This paper deals with mixed model assembly line (MMAL balancing problem of type-I. In MMALs several products are made on an assembly line while the similarity of these products is so high. As a result, it is possible to assemble several types of products simultaneously without any additional setup times. The problem has some particular features such as parallel workstations and precedence constraints in dynamic periods in which each period also effects on its next period. The research intends to reduce the number of workstations and maximize the workload smoothness between workstations. Dynamic periods are used to determine all variables in different periods to achieve efficient solutions. A non-dominated sorting genetic algorithm (NSGA-II and multi-objective particle swarm optimization (MOPSO are used to solve the problem. The proposed model is validated with GAMS software for small size problem and the performance of the foregoing algorithms is compared with each other based on some comparison metrics. The NSGA-II outperforms MOPSO with respect to some comparison metrics used in this paper, but in other metrics MOPSO is better than NSGA-II. Finally, conclusion and future research is provided.

Multi-MW K-Band Harmonic Multiplier: RF Source For High-Gradient Accelerator R & D

Science.gov (United States)

Solyak, N. A.; Yakovlev, V. P.; Kazakov, S. Yu.; Hirshfield, J. L.

2009-01-01

A preliminary design is presented for a two-cavity harmonic multiplier, intended as a high-power RF source for use in experiments aimed at developing high-gradient structures for a future collider. The harmonic multiplier is to produce power at selected frequencies in K-band (18-26.5 GHz) using as an RF driver an XK-5 S-band klystron (2.856 GHz). The device is to be built with a TE111 rotating mode input cavity and interchangeable output cavities running in the TEn11 rotating mode, with n = 7,8,9 at 19.992, 22.848, and 25.704 GHz. An example for a 7th harmonic multiplier is described, using a 250 kV, 20 A injected laminar electron beam; with 10 MW of S-band drive power, 4.7 MW of 20-GHz output power is predicted. Details are described of the magnetic circuit, cavities, and output coupler.

Cooperative motion control for multi-target observation

Energy Technology Data Exchange (ETDEWEB)

Parker, L.E.

1997-08-01

An important issue that arises in the automation of many security, surveillance, and reconnaissance tasks is that of monitoring (or observing) the movements of targets navigating in a bounded area of interest. A key research issue in these problems is that of sensor placement--determining where sensors should be located to maintain the targets in view. In complex applications involving limited-range sensors, the use of multiple sensors dynamically moving over time is required. In this paper, the author investigates the use of a cooperative team of autonomous sensor-based robots for the observation of multiple moving targets. The focus is primarily on developing the distributed control strategies that allow the robot team to attempt to minimize the total time in which targets escape observation by some robot team member in the area of interest. This paper first formalizes the problem and discusses related work. The author then presents a distributed approximate approach to solving this problem that combines low-level multi-robot control with higher-level reasoning control based on the ALLIANCE formalism. The effectiveness of the approach is analyzed by comparing it to three other feasible algorithms for cooperative control, showing the superiority of the approach for a large class of problems.

Cooperative motion control for multi-target observation

International Nuclear Information System (INIS)

Parker, L.E.

1997-01-01

An important issue that arises in the automation of many security, surveillance, and reconnaissance tasks is that of monitoring (or observing) the movements of targets navigating in a bounded area of interest. A key research issue in these problems is that of sensor placement--determining where sensors should be located to maintain the targets in view. In complex applications involving limited-range sensors, the use of multiple sensors dynamically moving over time is required. In this paper, the author investigates the use of a cooperative team of autonomous sensor-based robots for the observation of multiple moving targets. The focus is primarily on developing the distributed control strategies that allow the robot team to attempt to minimize the total time in which targets escape observation by some robot team member in the area of interest. This paper first formalizes the problem and discusses related work. The author then presents a distributed approximate approach to solving this problem that combines low-level multi-robot control with higher-level reasoning control based on the ALLIANCE formalism. The effectiveness of the approach is analyzed by comparing it to three other feasible algorithms for cooperative control, showing the superiority of the approach for a large class of problems

Comparison of multi-MW converters considering the determining factors in wind power application

DEFF Research Database (Denmark)

Ma, Ke; Liserre, Marco; Blaabjerg, Frede

2013-01-01

converters are normally targeted to the industrial drive applications, and they did not take into account the special requirements in the case of wind power. This paper tries to unify and compare several promising wind power converters by a series new model and perspective. The evaluation criteria...... will mainly focus on the costeffectiveness of power semiconductors and the converter performances when complying with grid codes - which are more crucial for the wind power converters. It is concluded that the power converters with various voltage levels, topologies, and paralleling structures are possible...... to be unified for comparison. And the two-level low-voltage converter solution still shows cost advantage regarding power semiconductors, while some multi-level medium-voltage converter solutions can show better performance when complying with the grid codes....

An efficient enzyme-powered micromotor device fabricated by cyclic alternate hybridization assembly for DNA detection.

Science.gov (United States)

Fu, Shizhe; Zhang, Xueqing; Xie, Yuzhe; Wu, Jie; Ju, Huangxian

2017-07-06

An efficient enzyme-powered micromotor device was fabricated by assembling multiple layers of catalase on the inner surface of a poly(3,4-ethylenedioxythiophene and sodium 4-styrenesulfonate)/Au microtube (PEDOT-PSS/Au). The catalase assembly was achieved by programmed DNA hybridization, which was performed by immobilizing a designed sandwich DNA structure as the sensing unit on the PEDOT-PSS/Au, and then alternately hybridizing with two assisting DNA to bind the enzyme for efficient motor motion. The micromotor device showed unique features of good reproducibility, stability and motion performance. Under optimal conditions, it showed a speed of 420 μm s -1 in 2% H 2 O 2 and even 51 μm s -1 in 0.25% H 2 O 2 . In the presence of target DNA, the sensing unit hybridized with target DNA to release the multi-layer DNA as well as the multi-catalase, resulting in a decrease of the motion speed. By using the speed as a signal, the micromotor device could detect DNA from 10 nM to 1 μM. The proposed micromotor device along with the cyclic alternate DNA hybridization assembly technique provided a new path to fabricate efficient and versatile micromotors, which would be an exceptional tool for rapid and simple detection of biomolecules.

RAGRAF: a computer code for calculating temperature distributions in multi-pin fuel assemblies in a stagnant gas atmosphere

International Nuclear Information System (INIS)

Eastham, A.

1979-02-01

A method of calculating the temperature distribution in a cross-section of a multi-pin nuclear reactor fuel assembly has been computerised. It utilises the thermal radiation interchange between individual fuel pins in either a square or triangular pitched lattice. A stagnant gas atmosphere within the fuel assembly is assumed which inhibits natural convection but permits thermal conduction between adjacent fuel pins. no restriction is placed upon the shape of wrapper used, but its temperature must always be uniform. RAGRAF has great flexibility because of the many options it provides. Although, essentially, it is a transient code, steady state solutions may be readily identified from successive temperature prints. An enclosure for the assembly wrapper is available, to be included or discarded at will during transient calculations. outside the limit of the assembly wrapper, any type or combination of heat transfer mode may be included. Transient variations in boundary temperature may be included if required. (author)

The National Spallation Neutron Source Target Station.

Science.gov (United States)

Gabriel, T. A.

1997-05-01

The technologies that are being utilized to design and build a state-of-the-art high powered (>= 1 MW), short pulsed (storage ring. Many scientific and technical disciplines are required to produce a successful target station. These disciplines include engineering, remote handling, neutronics, materials, thermal hydraulics, shock analysis, etc. In the areas of engineering and remote handling special emphasis is being given to rapid and efficient assembly and disassembly of critical parts of the target station. In the neutronics area, emphasis is being given to neutron yield and pulse optimization from the moderators, and heating and activation rates throughout the station. Development of structural materials to withstand aggressive radiation environments and that are compatible with other materials is also an important area. Thermal hydraulics and shock analysis are being closely studied since large amounts of energy are being deposited in small volumes in relatively short time periods (< 1 μsec). These areas will be expanded upon in the paper.

Scar-less multi-part DNA assembly design automation

Science.gov (United States)

Hillson, Nathan J.

2016-06-07

The present invention provides a method of a method of designing an implementation of a DNA assembly. In an exemplary embodiment, the method includes (1) receiving a list of DNA sequence fragments to be assembled together and an order in which to assemble the DNA sequence fragments, (2) designing DNA oligonucleotides (oligos) for each of the DNA sequence fragments, and (3) creating a plan for adding flanking homology sequences to each of the DNA oligos. In an exemplary embodiment, the method includes (1) receiving a list of DNA sequence fragments to be assembled together and an order in which to assemble the DNA sequence fragments, (2) designing DNA oligonucleotides (oligos) for each of the DNA sequence fragments, and (3) creating a plan for adding optimized overhang sequences to each of the DNA oligos.

Modelling and simulation of containment on full scope simulator for Qinshan 300 MW Nuclear Power Unit

International Nuclear Information System (INIS)

Zou Tingyun

1996-01-01

A multi-node containment thermal-hydraulic model has been developed and adapted in Full Scope Simulator for Qinshan 300 MW Nuclear Power Unit with good realtime simulation effects. Containment pressure for LBLOCA calculated by the model is well agreed with those of CONTEMPT-4/MOD3

Multi-recycling of transuranic elements in a PWR assembly with reduced fuel rod diameter

International Nuclear Information System (INIS)

Chambers, Alex; Ragusa, Jean C.

2014-01-01

Highlights: • Study of multiple recycling passes of transuranic elements: (a) without exceeding 5 wt.% on U-235 enrichment; (b) using PWR fuel assemblies compatible with current reactor core internals. • Isotopic concentrations tend towards an equilibrium after 15 recycle passes, suggesting that thermal recycling may be continued beyond that point. • Radiotoxicity comparisons for once-through UOX, once-recycle MOX-Pu, and multiple recycle passes of MOX-PuNpAm and MOX-PuNpAmCm are presented. - Abstract: This paper examines the multi-recycling of transuranic (TRU) elements (Pu-Np-Am-Cm) in standard Pressurized Water Reactor (PWR) assemblies. The original feed of TRU comes from legacy spent UOX fuel. For all subsequent recycling passes, TRU elements from the previous generation are employed, supplemented by TRU from legacy UOX fuel, as needed. The design criteria include: 235 U enrichment requirements to remain below 5 w/o, TRU loading limits to avoid return to criticality under voided conditions, and assembly power peaking factors. In order to carry out multiple recycling passes within the design envelope, additional neutron moderation is required and achieved by reducing the fuel pellet diameter by about 13%, thus keeping the assembly design compatible with current PWR core internals. TRU transmutation rates and long-term ingestion radiotoxicity results are presented for 15 recycling passes and compared to standard UOX and MOX once-through cycles. The results also show that TRU fuel isotopics and radiotoxicity tend towards an equilibrium, enabling further additional recycling passes

Preliminary conceptual design of target system. Pt. 1. System configuration

Energy Technology Data Exchange (ETDEWEB)

Hino, Ryutaro; Haga, Katsuhiro; Kaminaga, Masanori [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment] [and others

1997-07-01

In the 21st century, neutron is expected to play a very important role in the fields of structural biology, nuclear physics, material science if a very high-intensity neutron source will be built because of its superior nature as an probe to investigate material structure and its function. The Japan Atomic Energy Research Institute has launched the Neutron Science Project for construction and utilization of a high-intensity spallation neutron source coupled with a proton accelerator. In the project, a neutron scattering facility is planned to be constructed in an early stage. Development of a 5MW spallation neutron source is one of the most difficult technical challenges in this project. A two-step development plan of the target was established to construct a 5MW-target station In the 1st step, a 1.5MW target will be constructed to develop 5MW target technology. The preliminary conceptual design was conducted to clarify the specifications of the target system of 1.5MW and 5MW including system layout, scale etc. This report describes (1) a design policy, (2) a layout of system consisting of the target, remote-handling devices, bio-shieldings etc., (3) specifications of components and facilities such as cooling systems for target and moderators, beam-port shutter and air conditioning system, (4) overhaul procedures by remote-handling devices, (5) safety assessment, and (6) necessary R and D items derived from the design activity. (author)

Facile synthesis of nanorod-assembled multi-shelled Co3O4 hollow microspheres for high-performance supercapacitors

Science.gov (United States)

Wang, Yaping; Pan, Anqiang; Zhu, Qinyu; Nie, Zhiwei; Zhang, Yifang; Tang, Yan; Liang, Shuquan; Cao, Guozhong

2014-12-01

In this work, we report a novel strategy for the controlled synthesis of nanorod assembled multi-shelled cobalt oxide (Co3O4) hollow microspheres (HSs). The Co2CO3(OH)2 NRs are first vertically grown on the carbon microspheres (CS) to form the core-shelled composites by a low-temperature solution route. The multi-shelled hollow interiors within the Co3O4 microspheres are unconventionally obtained by annealing the as-prepared core-shell structured CS@Co2CO3(OH)2 composite in air. When evaluated for supercapacitive performance, the multi-shelled Co3O4 hollow microspheres exhibit high capacitance of 394.4 and 360 F g-1 at the current densities of 2 A g-1 and 10 A g-1, respectively. The superior electrochemical performance can be attributed to the multi-shelled hollow structures, which facilitate the electrolyte penetration and provide more active sites for the electrochemical reactions.

Entanglement of conjugated polymer chains influences molecular self-assembly and carrier transport

KAUST Repository

Zhao, Kui; Khan, Hadayat Ullah; Li, Ruipeng; Su, Yisong; Amassian, Aram

2013-01-01

The influence of polymer entanglement on the self-assembly, molecular packing structure, and microstructure of low-Mw (lightly entangled) and high-Mw (highly entangled) poly (3-hexylthiophene) (P3HT), and the carrier transport in thin-film transistors, are investigated. The polymer chains are gradually disentangled in a marginal solvent via ultrasonication of the polymer solution, and demonstrate improved diffusivity of precursor species (coils, aggregates, and microcrystallites), enhanced nucleation and crystallization of P3HT in solution, and self-assembly of well-ordered and highly textured fibrils at the solid-liquid interface. In low-Mw P3HT, reducing chain entanglement enhances interchain and intrachain ordering, but reduces the interconnectivity of ordered domains (tie molecules) due to the presence of short chains, thus deteriorating carrier transport even in the face of improving crystallinity. Reducing chain entanglement in high-Mw P3HT solutions increases carrier mobility up to ≈20-fold, by enhancing interchain and intrachain ordering while maintaining a sufficiently large number of tie molecules between ordered domains. These results indicate that charge carrier mobility is strongly governed by the balancing of intrachain and interchain ordering, on the one hand, and interconnectivity of ordered domains, on the other hand. In high-Mw P3HT, intrachain and interchain ordering appear to be the key bottlenecks to charge transport, whereas in low-Mw P3HT, the limited interconnectivity of the ordered domains acts as the primary bottleneck to charge transport. Conjugated polymer chains of poly(3-hexylthiophene) (P3HT) are gradually disentangled in solution and trends in carrier transport mechanisms in organic thin film transistors for low- and high-molecular weight P3HT are investigated. While intrachain and interchain ordering within ordered domains are the key bottlenecks to charge transport in high-Mw P3HT films, the limited interconnectivity of ordered

Entanglement of conjugated polymer chains influences molecular self-assembly and carrier transport

KAUST Repository

Zhao, Kui

2013-06-26

The influence of polymer entanglement on the self-assembly, molecular packing structure, and microstructure of low-Mw (lightly entangled) and high-Mw (highly entangled) poly (3-hexylthiophene) (P3HT), and the carrier transport in thin-film transistors, are investigated. The polymer chains are gradually disentangled in a marginal solvent via ultrasonication of the polymer solution, and demonstrate improved diffusivity of precursor species (coils, aggregates, and microcrystallites), enhanced nucleation and crystallization of P3HT in solution, and self-assembly of well-ordered and highly textured fibrils at the solid-liquid interface. In low-Mw P3HT, reducing chain entanglement enhances interchain and intrachain ordering, but reduces the interconnectivity of ordered domains (tie molecules) due to the presence of short chains, thus deteriorating carrier transport even in the face of improving crystallinity. Reducing chain entanglement in high-Mw P3HT solutions increases carrier mobility up to ≈20-fold, by enhancing interchain and intrachain ordering while maintaining a sufficiently large number of tie molecules between ordered domains. These results indicate that charge carrier mobility is strongly governed by the balancing of intrachain and interchain ordering, on the one hand, and interconnectivity of ordered domains, on the other hand. In high-Mw P3HT, intrachain and interchain ordering appear to be the key bottlenecks to charge transport, whereas in low-Mw P3HT, the limited interconnectivity of the ordered domains acts as the primary bottleneck to charge transport. Conjugated polymer chains of poly(3-hexylthiophene) (P3HT) are gradually disentangled in solution and trends in carrier transport mechanisms in organic thin film transistors for low- and high-molecular weight P3HT are investigated. While intrachain and interchain ordering within ordered domains are the key bottlenecks to charge transport in high-Mw P3HT films, the limited interconnectivity of ordered

Neutronic analysis for the fission Mo99 production by irradiation of leu targets in TRIGA 14 MW reactor

International Nuclear Information System (INIS)

Dulugeac, S. D.; Mladin, M.; Budriman, A. G.

2013-01-01

Molybdenum production can be a solution for the future in the utilization of the Romanian TRIGA, taking into account the international market supply needs. Generally, two different techniques are available for Mo 99 production for use in medical Tc 99 generation.The first one is based on neutron irradiation of molybdenum targets of natural isotopic composition or enriched in Mo 98 . In a second process, Mo 99 is obtained as a result of the neutron induced fission of U 235 according to U 235 (n,f) Mo 99 . The objectives of the paper are related to Mo 99 production as a result of fission. Neutron physics parameters are determined and presented, such as: thermal flux axial distribution for the critical reactor at 10 MW inside the irradiation location; reactivity introduced by three Uranium foil containers; neutron fluxes and fission rates in the Uranium foils; released and deposited power in the Uranium foils; Mo 99 activity in the Uranium foils. (authors)

A Multi-targeted Approach to Suppress Tumor-Promoting Inflammation

Science.gov (United States)

Samadi, Abbas K.; Georgakilas, Alexandros G.; Amedei, Amedeo; Amin, Amr; Bishayee, Anupam; Lokeshwar, Bal L.; Grue, Brendan; Panis, Carolina; Boosani, Chandra S.; Poudyal, Deepak; Stafforini, Diana M.; Bhakta, Dipita; Niccolai, Elena; Guha, Gunjan; Rupasinghe, H.P. Vasantha; Fujii, Hiromasa; Honoki, Kanya; Mehta, Kapil; Aquilano, Katia; Lowe, Leroy; Hofseth, Lorne J.; Ricciardiello, Luigi; Ciriolo, Maria Rosa; Singh, Neetu; Whelan, Richard L.; Chaturvedi, Rupesh; Ashraf, S. Salman; Kumara, HMC Shantha; Nowsheen, Somaira; Mohammed, Sulma I.; Helferich, William G.; Yang, Xujuan

2015-01-01

Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-kappaB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes. PMID:25951989

Transmutation of uranium and thorium in the particle field of the Quinta sub-critical assembly

Science.gov (United States)

Hashemi-Nezhad, S. R.; Asquith, N. L.; Voronko, V. A.; Sotnikov, V. V.; Zhadan, Alina; Zhuk, I. V.; Potapenko, A.; Husak, Krystsina; Chilap, V.; Adam, J.; Baldin, A.; Berlev, A.; Furman, W.; Kadykov, M.; Khushvaktov, J.; Kudashkin, I.; Mar'in, I.; Paraipan, M.; Pronskih, V.; Solnyshkin, A.; Tyutyunnikov, S.

2018-03-01

The fission rates of natural uranium and thorium were measured in the particle field of Quinta, a 512 kg natural uranium target-blanket sub-critical assembly. The Quinta assembly was irradiated with deuterons of energy 4 GeV from the Nuclotron accelerator of the Joint Institute for Nuclear Research (JINR), Dubna, Russia. Fission rates of uranium and thorium were measured using Gamma spectroscopy and fission track techniques. The production rate of 239Np was also measured. The obtained experimental results were compared with Monte Carlo predictions using the MCNPX 2.7 code employing the physics and fission-evaporation models of INCL4-ABLA, CEM03.03 and LAQGSM03.03. Some of the neutronic characteristics of the Quinta are compared with the "Energy plus Transmutation (EpT)" subcritical assembly, which is composed of a lead target and natU blanket. This comparison clearly demonstrates the importance of target material, neutron moderator and reflector types on the performance of a spallation neutron driven subcritical system. As the dimensions of the Quinta are very close to those of an optimal multi-rod-uranium target, the experimental and Monte Carlo calculation results presented in this paper provide insights on the particle field within a uranium target as well as in Accelerator Driven Systems in general.

Fuel assembly storage pool

International Nuclear Information System (INIS)

Hiranuma, Hiroshi.

1976-01-01

Object: To remove limitation of the number of storage of fuel assemblies to increase the number of storage thereof so as to relatively reduce the water depth required for shielding radioactive rays. Structure: Fuel assembly storage rack containers for receiving a plurality of spent fuel assembly racks are stacked in multi-layer fashion within a storage pool filled with water for shielding radioactive rays and removing heat. (Furukawa, Y.)

New results in development of MW output power gyrotrons for fusion systems

International Nuclear Information System (INIS)

Litvak, A.G.; Denisov, G.G.; Ilin, V.I.; Kurbatov, V.I.; Myasnikov, V.E.; Soluyanova, E.A.; Tai, E.M.; Usachev, S.V.; Zapevalov, V.E.

2005-01-01

The paper presents the latest achievements of the Russian gyrotron team in development of MW power gyrotrons for fusion installations. During two last years four new gyrotrons were designed and tested: a new version of 170 GHz gyrotron for ITER; multi-frequency (105-140 GHz) gyrotron for Asdex-Up, 84GHz gyrotron for LHD and 82.7 GHz gyrotron for SST-1. All these gyrotrons are equipped with diamond CVD windows and depressed collectors

SU-E-T-480: Radiobiological Dose Comparison of Single Fraction SRS, Multi-Fraction SRT and Multi-Stage SRS of Large Target Volumes Using the Linear-Quadratic Formula

International Nuclear Information System (INIS)

Ding, C; Hrycushko, B; Jiang, S; Meyer, J; Timmerman, R

2014-01-01

Purpose: To compare the radiobiological effect on large tumors and surrounding normal tissues from single fraction SRS, multi-fractionated SRT, and multi-staged SRS treatment. Methods: An anthropomorphic head phantom with a centrally located large volume target (18.2 cm 3 ) was scanned using a 16 slice large bore CT simulator. Scans were imported to the Multiplan treatment planning system where a total prescription dose of 20Gy was used for a single, three staged and three fractionated treatment. Cyber Knife treatment plans were inversely optimized for the target volume to achieve at least 95% coverage of the prescription dose. For the multistage plan, the target was segmented into three subtargets having similar volume and shape. Staged plans for individual subtargets were generated based on a planning technique where the beam MUs of the original plan on the total target volume are changed by weighting the MUs based on projected beam lengths within each subtarget. Dose matrices for each plan were export in DICOM format and used to calculate equivalent dose distributions in 2Gy fractions using an alpha beta ratio of 10 for the target and 3 for normal tissue. Results: Singe fraction SRS, multi-stage plan and multi-fractionated SRT plans had an average 2Gy dose equivalent to the target of 62.89Gy, 37.91Gy and 33.68Gy, respectively. The normal tissue within 12Gy physical dose region had an average 2Gy dose equivalent of 29.55Gy, 16.08Gy and 13.93Gy, respectively. Conclusion: The single fraction SRS plan had the largest predicted biological effect for the target and the surrounding normal tissue. The multi-stage treatment provided for a more potent biologically effect on target compared to the multi-fraction SRT treatments with less biological normal tissue than single-fraction SRS treatment

Artificial ground motion compatible with specified peak ground displacement and target multi-damping response spectra

International Nuclear Information System (INIS)

Zhang Yushan; Zhao Fengxin

2010-01-01

With respect to the design ground motion of nuclear power plant (NPP), the Regular Guide 1.60 of the US not only defined the standard multi-damping response spectra, i.e. the RG1.60 spectra, but also definitely prescribed the peak ground displacement (PGD) value corresponding to the standard spectra. However, in the engineering practice of generating multi-damping-spectra-compatible artificial ground motion for the seismic design of NPP, the PGD value had been neglected. Addressing this issue, this paper proposed a synthesizing method which generates the artificial ground motion compatible with not only the target multi-damping response spectra but also the specified PGD value. Firstly, by the transfer formula between the power spectrum and the response spectrum, an initial uniformly modulated acceleration time history is synthesized by multiplying the stationary Gaussian process with the prescribed intensity envelope to simulate the amplitude-non-stationarity of earthquake ground motion. And then by superimposing a series of narrow-band time histories in the time domain, the initial time history is modified in the iterative manner to match the target PGD as well as the target multi-damping spectra with the pre-specified matching precisions. Numerical examples are provided to demonstrate the matching precisions of the proposed method to the target values.

Status of the development of the EU 170 GHz/1 MW/CW gyrotron

Energy Technology Data Exchange (ETDEWEB)

Pagonakis, Ioannis Gr., E-mail: ioannis.pagonakis@kit.edu [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); Albajar, Ferran [The European Joint Undertaking for ITER and The Development of Fusion Energy, Barcelona (Spain); Alberti, Stefano [École Polytechnique Fédérale de Lausanne, Centre de Recherches en Physique des Plasmas (CRPP), Lausanne (Switzerland); Avramidis, Konstantinos [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); Bonicelli, Tullio [The European Joint Undertaking for ITER and The Development of Fusion Energy, Barcelona (Spain); Braunmueller, Falk [École Polytechnique Fédérale de Lausanne, Centre de Recherches en Physique des Plasmas (CRPP), Lausanne (Switzerland); Bruschi, Alex [Plasma Physics Institute, National Research Council of Italy, Milano (Italy); Chelis, Ioannis [School of Electrical and Computer Engineering, National Technical University of Athens (Greece); Cismondi, Fabio [The European Joint Undertaking for ITER and The Development of Fusion Energy, Barcelona (Spain); Gantenbein, Gerd [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); Hermann, Virgile [Thales Electron Devices (TED), Vélizy-Villacoublay (France); Hesch, Klaus [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); Hogge, Jean-Philippe [École Polytechnique Fédérale de Lausanne, Centre de Recherches en Physique des Plasmas (CRPP), Lausanne (Switzerland); Jelonnek, John; Jin, Jianbo; Illy, Stefan [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); Ioannidis, Zisis C. [Faculty of Physics, National and Kapodistrian University of Athens (Greece); Kobarg, Thorsten [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); and others

2015-10-15

The progress in the development of the European 170 GHz, 1 MW/CW gyrotron for electron cyclotron heating & current drive (ECH&CD) on ITER is reported. A continuous wave (CW) prototype is being manufactured by Thales Electron Devices (TED), France, while a short-pulse (SP) prototype gyrotron is in parallel under manufacture at Karlsruhe Institute of Technology (KIT), with the purpose of validating the design of the CW industrial prototype components. The fabrication of most of the sub-assemblies of the SP prototype has been completed. In a first step, an existing magnetron injection gun (MIG) available at KIT was used. Despite this non-ideal configuration, the experiments provided a validation of the design, substantiated by an excellent agreement with numerical simulations. The tube, operated without a depressed collector, is able to produce more than 1 MW of output power with efficiency in excess of 30%, as expected, and compatible with the ITER requirements.

Accurate multi-robot targeting for keyhole neurosurgery based on external sensor monitoring.

Science.gov (United States)

Comparetti, Mirko Daniele; Vaccarella, Alberto; Dyagilev, Ilya; Shoham, Moshe; Ferrigno, Giancarlo; De Momi, Elena

2012-05-01

Robotics has recently been introduced in surgery to improve intervention accuracy, to reduce invasiveness and to allow new surgical procedures. In this framework, the ROBOCAST system is an optically surveyed multi-robot chain aimed at enhancing the accuracy of surgical probe insertion during keyhole neurosurgery procedures. The system encompasses three robots, connected as a multiple kinematic chain (serial and parallel), totalling 13 degrees of freedom, and it is used to automatically align the probe onto a desired planned trajectory. The probe is then inserted in the brain, towards the planned target, by means of a haptic interface. This paper presents a new iterative targeting approach to be used in surgical robotic navigation, where the multi-robot chain is used to align the surgical probe to the planned pose, and an external sensor is used to decrease the alignment errors. The iterative targeting was tested in an operating room environment using a skull phantom, and the targets were selected on magnetic resonance images. The proposed targeting procedure allows about 0.3 mm to be obtained as the residual median Euclidean distance between the planned and the desired targets, thus satisfying the surgical accuracy requirements (1 mm), due to the resolution of the diffused medical images. The performances proved to be independent of the robot optical sensor calibration accuracy.

Hitting emissions targets with (statistical) confidence in multi-instrument Emissions Trading Schemes

International Nuclear Information System (INIS)

Shipworth, David

2003-12-01

A means of assessing, monitoring and controlling aggregate emissions from multi-instrument Emissions Trading Schemes is proposed. The approach allows contributions from different instruments with different forms of emissions targets to be integrated. Where Emissions Trading Schemes are helping to meet specific national targets, the approach allows the entry requirements of new participants to be calculated and set at a level that will achieve these targets. The approach is multi-levelled, and may be extended downwards to support pooling of participants within instruments, or upwards to embed Emissions Trading Schemes within a wider suite of policies and measures with hard and soft targets. Aggregate emissions from each instrument are treated stochastically. Emissions from the scheme as a whole are then the joint probability distribution formed by integrating the emissions from its instruments. Because a Bayesian approach is adopted, qualitative and semi-qualitative data from expert opinion can be used where quantitative data is not currently available, or is incomplete. This approach helps government retain sufficient control over emissions trading scheme targets to allow them to meet their emissions reduction obligations, while minimising the need for retrospectively adjusting existing participants' conditions of entry. This maintains participant confidence, while providing the necessary policy levers for good governance

Industrializing Offshore Wind Power with Serial Assembly and Lower-cost Deployment - Final Report

Energy Technology Data Exchange (ETDEWEB)

Kempton, Willett [Univ. of Delaware, Newark, DE (United States)

2017-12-11

A team of engineers and contractors has developed a method to move offshore wind installation toward lower cost, faster deployment, and lower environmental impact. A combination of methods, some incremental and some breaks from past practice, interact to yield multiple improvements. Three designs were evaluated based on detailed engineering: 1) a 5 MW turbine on a jacket with pin piles (base case), 2) a 10 MW turbine on a conventional jacket with pin piles, assembled at sea, and 3) a 10 MW turbine on tripod jacket with suction buckets (caissons) and with complete turbine assembly on-shore. The larger turbine, assembly ashore, and the use of suction buckets together substantially reduce capital cost of offshore wind projects. Notable capital cost reductions are: changing from 5 MW to 10 MW turbine, a 31% capital cost reduction, and assembly on land then single-piece install at sea an additional 9% capital cost reduction. An estimated Design 4) estimates further cost reduction when equipment and processes of Design 3) are optimized, rather than adapted to existing equipment and process. Cost of energy for each of the four Designs are also calculated, yielding approximately the same percentage reductions. The methods of Design 3) analyzed here include accepted structures such as suction buckets used in new ways, innovations conceived but previously without engineering and economic validation, combined with new methods not previously proposed. Analysis of Designs 2) and 3) are based on extensive engineering calculations and detailed cost estimates. All design methods can be done with existing equipment, including lift equipment, ports and ships (except that design 4 assumes a more optimized ship). The design team consists of experienced offshore structure designers, heavy lift engineers, wind turbine designers, vessel operators, and marine construction contractors. Comparing the methods based on criteria of cost and deployment speed, the study selected the third design

Analysis of the thermomechanical behavior of the IFMIF bayonet target assembly under design loading scenarios

Energy Technology Data Exchange (ETDEWEB)

Bernardi, D., E-mail: davide.bernardi@enea.it [ENEA Brasimone, Camugnano, BO (Italy); Arena, P.; Bongiovì, G.; Di Maio, P.A. [Dipartimento di Energia, Ingegneria dell’Informazione e Modelli Matematici, Università di Palermo, Viale delle Scienze, Palermo (Italy); Frisoni, M. [ENEA Bologna, Via Martiri di Monte Sole 4, Bologna (Italy); Miccichè, G.; Serra, M. [ENEA Brasimone, Camugnano, BO (Italy)

2015-10-15

In the framework of the IFMIF Engineering Validation and Engineering Design Activities (IFMIF/EVEDA) phase, ENEA is responsible for the design of the European concept of the IFMIF lithium target system which foresees the possibility to periodically replace only the most irradiated and thus critical component (i.e., the backplate) while continuing to operate the rest of the target for a longer period (the so-called bayonet backplate concept). In this work, the results of the steady state thermomechanical analysis of the IFMIF bayonet target assembly under two different design loading scenarios (a “hot” scenario and a “cold” scenario) are briefly reported highlighting the relevant indications obtained with respect to the fulfillment of the design requirements. In particular, the analyses have shown that in the hot scenario the temperatures reached in the target assembly are within the material acceptable limits while in the cold scenario transition below the ductile to brittle transition temperature (DBTT) cannot be excluded. Moreover, results indicate that the contact between backplate and high flux test module is avoided and that the overall structural integrity of the system is assured in both scenarios. However, stress linearization analysis reveals that ITER Structural Design Criteria for In-vessel Components (SDC-IC) design rules are not always met along the selected paths at backplate middle plane section in the hot scenario, thus suggesting the need of a revision of the backplate design or a change of the operating conditions.

The design of a lead-bismuth target system with a dual injection tube

International Nuclear Information System (INIS)

Cho, C.H.; Kim, Y.; Song, T.Y.; Park, W.S.

2005-01-01

A spallation target system is a key component to be developed for an accelerator driven system (ADS). It is known that a 15 ∼ 25 MW spallation target is required for a practical 1000 MWth ADS. The design of a 20 MW spallation target is very challenging because more than 60% of the beam power is deposited as heat in a small volume of the target system. In the present work, a numerical design study was performed to obtain the optimal design parameters for a 20 MW spallation target for a 1000 MW ADS. A dual injection tube was proposed for the reduction of the LBE flow rate at the target channel. The results of the present study show that a 30 cm wide proton beam with a uniform beam distribution should be adopted for the spallation target of a 20 MW power. When the dual LBE injection tube is employed, the LBE flow rate could be reduced by a factor of 4 without reducing the maximum allowable beam current. (authors)

Multi-recycling of transuranic elements in a PWR assembly with reduced fuel rod diameter

Energy Technology Data Exchange (ETDEWEB)

Chambers, Alex, E-mail: acchamb@gmail.com; Ragusa, Jean C., E-mail: jean.ragusa@tamu.edu

2014-04-01

Highlights: • Study of multiple recycling passes of transuranic elements: (a) without exceeding 5 wt.% on U-235 enrichment; (b) using PWR fuel assemblies compatible with current reactor core internals. • Isotopic concentrations tend towards an equilibrium after 15 recycle passes, suggesting that thermal recycling may be continued beyond that point. • Radiotoxicity comparisons for once-through UOX, once-recycle MOX-Pu, and multiple recycle passes of MOX-PuNpAm and MOX-PuNpAmCm are presented. - Abstract: This paper examines the multi-recycling of transuranic (TRU) elements (Pu-Np-Am-Cm) in standard Pressurized Water Reactor (PWR) assemblies. The original feed of TRU comes from legacy spent UOX fuel. For all subsequent recycling passes, TRU elements from the previous generation are employed, supplemented by TRU from legacy UOX fuel, as needed. The design criteria include: {sup 235}U enrichment requirements to remain below 5 w/o, TRU loading limits to avoid return to criticality under voided conditions, and assembly power peaking factors. In order to carry out multiple recycling passes within the design envelope, additional neutron moderation is required and achieved by reducing the fuel pellet diameter by about 13%, thus keeping the assembly design compatible with current PWR core internals. TRU transmutation rates and long-term ingestion radiotoxicity results are presented for 15 recycling passes and compared to standard UOX and MOX once-through cycles. The results also show that TRU fuel isotopics and radiotoxicity tend towards an equilibrium, enabling further additional recycling passes.

Synergistic multi-sensor and multi-frequency retrieval of cloud ice water path constrained by CloudSat collocations

International Nuclear Information System (INIS)

Islam, Tanvir; Srivastava, Prashant K.

2015-01-01

The cloud ice water path (IWP) is one of the major parameters that have a strong influence on earth's radiation budget. Onboard satellite sensors are recognized as valuable tools to measure the IWP in a global scale. Albeit, active sensors such as the Cloud Profiling Radar (CPR) onboard the CloudSat satellite has better capability to measure the ice water content profile, thus, its vertical integral, IWP, than any passive microwave (MW) or infrared (IR) sensors. In this study, we investigate the retrieval of IWP from MW and IR sensors, including AMSU-A, MHS, and HIRS instruments on-board the N19 satellite, such that the retrieval is consistent with the CloudSat IWP estimates. This is achieved through the collocations between the passive satellite measurements and CloudSat scenes. Potential benefit of synergistic multi-sensor multi-frequency retrieval is investigated. Two modeling approaches are explored for the IWP retrieval – generalized linear model (GLM) and neural network (NN). The investigation has been carried out over both ocean and land surface types. The MW/IR synergy is found to be retrieved more accurate IWP than the individual AMSU-A, MHS, or HIRS measurements. Both GLM and NN approaches have been able to exploit the synergistic retrievals. - Highlights: • MW/IR synergy is investigated for IWP retrieval. • The IWP retrieval is modeled using CloudSat collocations. • Two modeling approaches are explored – GLM and ANN. • MW/IR synergy performs better than the MW or IR only retrieval

Multi-agent target tracking using particle filters enhanced with context data

CSIR Research Space (South Africa)

Claessens, R

2015-05-01

Full Text Available The proposed framework for Multi-Agent Target Tracking supports i) tracking of objects and ii) search and rescue based on the fusion of very heterogeneous data. The system is based on a novel approach to fusing sensory observations, intelligence...

A Bayesian solution to multi-target tracking problems with mixed labelling

NARCIS (Netherlands)

Aoki, E.H.; Boers, Y.; Svensson, Lennart; Mandal, Pranab K.; Bagchi, Arunabha

In Multi-Target Tracking (MTT), the problem of assigning labels to tracks (track labelling) is vastly covered in literature and has been previously formulated using Bayesian recursion. However, the existing literature lacks an appropriate measure of uncertainty related to the assigned labels which

Targeted nanodiamonds for identification of subcellular protein assemblies in mammalian cells

Science.gov (United States)

Lake, Michael P.; Bouchard, Louis-S.

2017-01-01

Transmission electron microscopy (TEM) can be used to successfully determine the structures of proteins. However, such studies are typically done ex situ after extraction of the protein from the cellular environment. Here we describe an application for nanodiamonds as targeted intensity contrast labels in biological TEM, using the nuclear pore complex (NPC) as a model macroassembly. We demonstrate that delivery of antibody-conjugated nanodiamonds to live mammalian cells using maltotriose-conjugated polypropylenimine dendrimers results in efficient localization of nanodiamonds to the intended cellular target. We further identify signatures of nanodiamonds under TEM that allow for unambiguous identification of individual nanodiamonds from a resin-embedded, OsO4-stained environment. This is the first demonstration of nanodiamonds as labels for nanoscale TEM-based identification of subcellular protein assemblies. These results, combined with the unique fluorescence properties and biocompatibility of nanodiamonds, represent an important step toward the use of nanodiamonds as markers for correlated optical/electron bioimaging. PMID:28636640

Targeted nanodiamonds for identification of subcellular protein assemblies in mammalian cells.

Directory of Open Access Journals (Sweden)

Michael P Lake

Full Text Available Transmission electron microscopy (TEM can be used to successfully determine the structures of proteins. However, such studies are typically done ex situ after extraction of the protein from the cellular environment. Here we describe an application for nanodiamonds as targeted intensity contrast labels in biological TEM, using the nuclear pore complex (NPC as a model macroassembly. We demonstrate that delivery of antibody-conjugated nanodiamonds to live mammalian cells using maltotriose-conjugated polypropylenimine dendrimers results in efficient localization of nanodiamonds to the intended cellular target. We further identify signatures of nanodiamonds under TEM that allow for unambiguous identification of individual nanodiamonds from a resin-embedded, OsO4-stained environment. This is the first demonstration of nanodiamonds as labels for nanoscale TEM-based identification of subcellular protein assemblies. These results, combined with the unique fluorescence properties and biocompatibility of nanodiamonds, represent an important step toward the use of nanodiamonds as markers for correlated optical/electron bioimaging.

Targeted nanodiamonds for identification of subcellular protein assemblies in mammalian cells.

Science.gov (United States)

Lake, Michael P; Bouchard, Louis-S

2017-01-01

Transmission electron microscopy (TEM) can be used to successfully determine the structures of proteins. However, such studies are typically done ex situ after extraction of the protein from the cellular environment. Here we describe an application for nanodiamonds as targeted intensity contrast labels in biological TEM, using the nuclear pore complex (NPC) as a model macroassembly. We demonstrate that delivery of antibody-conjugated nanodiamonds to live mammalian cells using maltotriose-conjugated polypropylenimine dendrimers results in efficient localization of nanodiamonds to the intended cellular target. We further identify signatures of nanodiamonds under TEM that allow for unambiguous identification of individual nanodiamonds from a resin-embedded, OsO4-stained environment. This is the first demonstration of nanodiamonds as labels for nanoscale TEM-based identification of subcellular protein assemblies. These results, combined with the unique fluorescence properties and biocompatibility of nanodiamonds, represent an important step toward the use of nanodiamonds as markers for correlated optical/electron bioimaging.

GRAbB: Selective Assembly of Genomic Regions, a New Niche for Genomic Research.

Directory of Open Access Journals (Sweden)

Balázs Brankovics

2016-06-01

Full Text Available GRAbB (Genomic Region Assembly by Baiting is a new program that is dedicated to assemble specific genomic regions from NGS data. This approach is especially useful when dealing with multi copy regions, such as mitochondrial genome and the rDNA repeat region, parts of the genome that are often neglected or poorly assembled, although they contain interesting information from phylogenetic or epidemiologic perspectives, but also single copy regions can be assembled. The program is capable of targeting multiple regions within a single run. Furthermore, GRAbB can be used to extract specific loci from NGS data, based on homology, like sequences that are used for barcoding. To make the assembly specific, a known part of the region, such as the sequence of a PCR amplicon or a homologous sequence from a related species must be specified. By assembling only the region of interest, the assembly process is computationally much less demanding and may lead to assemblies of better quality. In this study the different applications and functionalities of the program are demonstrated such as: exhaustive assembly (rDNA region and mitochondrial genome, extracting homologous regions or genes (IGS, RPB1, RPB2 and TEF1a, as well as extracting multiple regions within a single run. The program is also compared with MITObim, which is meant for the exhaustive assembly of a single target based on a similar query sequence. GRAbB is shown to be more efficient than MITObim in terms of speed, memory and disk usage. The other functionalities (handling multiple targets simultaneously and extracting homologous regions of the new program are not matched by other programs. The program is available with explanatory documentation at https://github.com/b-brankovics/grabb. GRAbB has been tested on Ubuntu (12.04 and 14.04, Fedora (23, CentOS (7.1.1503 and Mac OS X (10.7. Furthermore, GRAbB is available as a docker repository: brankovics/grabb (https://hub.docker.com/r/brankovics/grabb/.

Free-time and fixed end-point multi-target optimal control theory: Application to quantum computing

International Nuclear Information System (INIS)

Mishima, K.; Yamashita, K.

2011-01-01

Graphical abstract: The two-state Deutsch-Jozsa algortihm used to demonstrate the utility of free-time and fixed-end point multi-target optimal control theory. Research highlights: → Free-time and fixed-end point multi-target optimal control theory (FRFP-MTOCT) was constructed. → The features of our theory include optimization of the external time-dependent perturbations with high transition probabilities, that of the temporal duration, the monotonic convergence, and the ability to optimize multiple-laser pulses simultaneously. → The advantage of the theory and a comparison with conventional fixed-time and fixed end-point multi-target optimal control theory (FIFP-MTOCT) are presented by comparing data calculated using the present theory with those published previously [K. Mishima, K. Yamashita, Chem. Phys. 361 (2009) 106]. → The qubit system of our interest consists of two polar NaCl molecules coupled by dipole-dipole interaction. → The calculation examples show that our theory is useful for minor adjustment of the external fields. - Abstract: An extension of free-time and fixed end-point optimal control theory (FRFP-OCT) to monotonically convergent free-time and fixed end-point multi-target optimal control theory (FRFP-MTOCT) is presented. The features of our theory include optimization of the external time-dependent perturbations with high transition probabilities, that of the temporal duration, the monotonic convergence, and the ability to optimize multiple-laser pulses simultaneously. The advantage of the theory and a comparison with conventional fixed-time and fixed end-point multi-target optimal control theory (FIFP-MTOCT) are presented by comparing data calculated using the present theory with those published previously [K. Mishima, K. Yamashita, Chem. Phys. 361, (2009), 106]. The qubit system of our interest consists of two polar NaCl molecules coupled by dipole-dipole interaction. The calculation examples show that our theory is useful for minor

Multi-Target Screening and Experimental Validation of Natural Products from Selaginella Plants against Alzheimer's Disease

Directory of Open Access Journals (Sweden)

Yin-Hua Deng

2017-08-01

Full Text Available Alzheimer's disease (AD is a progressive and irreversible neurodegenerative disorder which is considered to be the most common cause of dementia. It has a greater impact not only on the learning and memory disturbances but also on social and economy. Currently, there are mainly single-target drugs for AD treatment but the complexity and multiple etiologies of AD make them difficult to obtain desirable therapeutic effects. Therefore, the choice of multi-target drugs will be a potential effective strategy inAD treatment. To find multi-target active ingredients for AD treatment from Selaginella plants, we firstly explored the behaviors effects on AD mice of total extracts (TE from Selaginella doederleinii on by Morris water maze test and found that TE has a remarkable improvement on learning and memory function for AD mice. And then, multi-target SAR models associated with AD-related proteins were built based on Random Forest (RF and different descriptors to preliminarily screen potential active ingredients from Selaginella. Considering the prediction outputs and the quantity of existing compounds in our laboratory, 13 compounds were chosen to carry out the in vitro enzyme inhibitory experiments and 4 compounds with BACE1/MAO-B dual inhibitory activity were determined. Finally, the molecular docking was applied to verify the prediction results and enzyme inhibitory experiments. Based on these study and validation processes, we explored a new strategy to improve the efficiency of active ingredients screening based on trace amount of natural product and numbers of targets and found some multi-target compounds with biological activity for the development of novel drugs for AD treatment.

An analysis of the proposed MITR-III core to establish thermal-hydraulic limits at 10 MW. Final report

International Nuclear Information System (INIS)

Harling, O.K.; Lanning, D.D.; Bernard, J.A.; Meyer, J.E.; Henry, A.F.

1997-01-01

The 5 MW Massachusetts Institute of Technology Research Reactor (MITR-II) is expected to operate under a new license beginning in 1999. Among the options being considered is an upgrade in the heat removal system to allow operation at 10 MW. The purpose of this study is to predict the Limiting Safety System Settings and Safety Limits for the upgraded reactor (MITR-III). The MITR Multi-Channel Analysis Code was written to analyze the response of the MITR system to a series of anticipated transients in order to determine the Limiting Safety System Settings and Safety Limits under various operating conditions. The MIT Multi-Channel Analysis Code models the primary and secondary systems, with special emphasis placed on analyzing the thermal-hydraulic conditions in the core. The code models each MITR fuel element explicitly in order to predict the behavior of the system during flow instabilities. The results of the code are compared to experimental data from MITR-II and other sources. New definitions are suggested for the Limiting Safety System Settings and Safety Limits. MITR Limit Diagrams are included for three different heat removal system configurations. It is concluded that safe, year-round operating at 10 MW is possible, given that the primary and secondary flow rates are both increased by approximately 40%

Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy.

Science.gov (United States)

Efferth, Thomas; Koch, Egon

2011-01-01

Drugs derived from natural resources represent a significant segment of the pharmaceutical market as compared to randomly synthesized compounds. It is a goal of drug development programs to design selective ligands that act on single disease targets to obtain highly effective and safe drugs with low side effects. Although this strategy was successful for many new therapies, there is a marked decline in the number of new drugs introduced into clinical practice over the past decades. One reason for this failure may be due to the fact that the pathogenesis of many diseases is rather multi-factorial in nature and not due to a single cause. Phytotherapy, whose therapeutic efficacy is based on the combined action of a mixture of constituents, offers new treatment opportunities. Because of their biological defence function, plant secondary metabolites act by targeting and disrupting the cell membrane, by binding and inhibiting specific proteins or they adhere to or intercalate into RNA or DNA. Phytotherapeutics may exhibit pharmacological effects by the synergistic or antagonistic interaction of many phytochemicals. Mechanistic reasons for interactions are bioavailability, interference with cellular transport processes, activation of pro-drugs or deactivation of active compounds to inactive metabolites, action of synergistic partners at different points of the same signalling cascade (multi-target effects) or inhibition of binding to target proteins. "-Omics" technologies and systems biology may facilitate unravelling synergistic effects of herbal mixtures.

The DAN-AERO MW Experiments

DEFF Research Database (Denmark)

Aagaard Madsen, Helge; Bak, Christian; Schmidt Paulsen, Uwe

a number of coordinated, innovative measurements on full scale MW size rotors as well as on airfoils for MW size turbines in wind tunnels. Shear and turbulence inflow characteristics were measured on a Siemens 3.6 MW turbine with a five hole pitot tube. Pressure and turbulent inflow characteristics were...... on the blade was further instrumented with around 50 microphones for high frequency surface pressure measurements. The surface pressure measurements have been correlated with inflow measurements from four five hole pitot tubes and two sensors for measuring the high frequency (50 Hz to10 kHz) contents...

Multi-UAV joint target recognizing based on binocular vision theory

Directory of Open Access Journals (Sweden)

Yuan Zhang

2017-01-01

Full Text Available Target recognizing of unmanned aerial vehicle (UAV based on image processing take the advantage of 2D information containing in the image for identifying the target. Compare to single UAV with electrical optical tracking system (EOTS, multi-UAV with EOTS is able to take a group of image focused on the suspected target from multiple view point. Benefit from matching each couple of image in this group, points set constituted by matched feature points implicates the depth of each point. Coordinate of target feature points could be computing from depth of feature points. This depth information makes up a cloud of points and reconstructed an exclusive 3D model to recognizing system. Considering the target recognizing do not require precise target model, the cloud of feature points was regrouped into n subsets and reconstructed to a semi-3D model. Casting these subsets in a Cartesian coordinate and applying these projections in convolutional neural networks (CNN respectively, the integrated output of networks is the improved result of recognizing.

Hot target assembly at 14 UD Pelletron Accelerator Facility, BARC- TIFR, Mumbai

International Nuclear Information System (INIS)

Sharma, S.C.; Ramjilal; Ninawe, N.G.; Bhagwat, P.V.; Ahmeabadhai, P.; Kain, V.

2005-01-01

BARC-TIFR 14 UD Pelletron Accelerator Facility at Mumbai is operational since 1989 with progressively increased efficiency. The accelerator has been serving as major facility for heavy ion based research in India. There is an increased demand for high current proton beam, especially on heated targets for reactor physics based experiments. A proton beam setup is commissioned in the tower area of the existing facility itself, which provide proton beam of energy 2 MeV to 26 MeV with maximum 3 μA current. This setup is being used to produce radioisotopes and tracer packets. Proton beam of few MeV in μA current range is also needed to study radiation effects on metals at higher temperature, for use in reactors. For this purpose a hot target assembly has been designed and is being currently used at the Pelletron Accelerator

Multi-Targeted Antithrombotic Therapy for Total Artificial Heart Device Patients.

Science.gov (United States)

Ramirez, Angeleah; Riley, Jeffrey B; Joyce, Lyle D

2016-03-01

To prevent thrombotic or bleeding events in patients receiving a total artificial heart (TAH), agents have been used to avoid adverse events. The purpose of this article is to outline the adoption and results of a multi-targeted antithrombotic clinical procedure guideline (CPG) for TAH patients. Based on literature review of TAH anticoagulation and multiple case series, a CPG was designed to prescribe the use of multiple pharmacological agents. Total blood loss, Thromboelastograph(®) (TEG), and platelet light-transmission aggregometry (LTA) measurements were conducted on 13 TAH patients during the first 2 weeks of support in our institution. Target values and actual medians for postimplant days 1, 3, 7, and 14 were calculated for kaolinheparinase TEG, kaolin TEG, LTA, and estimated blood loss. Protocol guidelines were followed and anticoagulation management reduced bleeding and prevented thrombus formation as well as thromboembolic events in TAH patients postimplantation. The patients in this study were susceptible to a variety of possible complications such as mechanical device issues, thrombotic events, infection, and bleeding. Among them all it was clear that patients were at most risk for bleeding, particularly on postoperative days 1 through 3. However, bleeding was reduced into postoperative days 3 and 7, indicating that acceptable hemostasis was achieved with the anticoagulation protocol. The multidisciplinary, multi-targeted anticoagulation clinical procedure guideline was successful to maintain adequate antithrombotic therapy for TAH patients.

Beam-target interaction for high-dose, multi-pulse radiography

International Nuclear Information System (INIS)

DeVolder, B.G.; Kwan, T.J.T.; Snell, C.M.; Kares, R.J.; McLenithan, K.D.

1996-01-01

The conversion of an intense relativistic electron beam into x-rays for radiographic imaging is achieved through the bremsstrahlung process of electrons in a tantalum or tungsten target of some optimal thickness. A high-dose radiographic source with small spot size is needed to achieve desirable resolution for thick objects. Consequently, an extremely high brightness electron beam is used and a significant amount of electron beam energy can be deposited in a small area of the target. The authors describe a computational methodology used to model the beam-target interaction and the evolution of the resultant plasma. Several codes, including particle-in-cell (PIC), Monte Carlo transport, and magnetohydrodynamic (MHD) codes, contribute to simulate different parts of the problem in a linked fashion. Issues addressed by the calculations include: the effects of the time dependence of the energy profile deposited in the target; the influence of the external magnetic field on plasma expansion; the influence of the expanding plasma on the guide magnetic field; radiation effects; and multi-dimensional effects

Confidence from uncertainty - A multi-target drug screening method from robust control theory

Directory of Open Access Journals (Sweden)

Petzold Linda R

2010-11-01

Full Text Available Abstract Background Robustness is a recognized feature of biological systems that evolved as a defence to environmental variability. Complex diseases such as diabetes, cancer, bacterial and viral infections, exploit the same mechanisms that allow for robust behaviour in healthy conditions to ensure their own continuance. Single drug therapies, while generally potent regulators of their specific protein/gene targets, often fail to counter the robustness of the disease in question. Multi-drug therapies offer a powerful means to restore disrupted biological networks, by targeting the subsystem of interest while preventing the diseased network from reconciling through available, redundant mechanisms. Modelling techniques are needed to manage the high number of combinatorial possibilities arising in multi-drug therapeutic design, and identify synergistic targets that are robust to system uncertainty. Results We present the application of a method from robust control theory, Structured Singular Value or μ- analysis, to identify highly effective multi-drug therapies by using robustness in the face of uncertainty as a new means of target discrimination. We illustrate the method by means of a case study of a negative feedback network motif subject to parametric uncertainty. Conclusions The paper contributes to the development of effective methods for drug screening in the context of network modelling affected by parametric uncertainty. The results have wide applicability for the analysis of different sources of uncertainty like noise experienced in the data, neglected dynamics, or intrinsic biological variability.

Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells.

Science.gov (United States)

Byrne, Susan M; Ortiz, Luis; Mali, Prashant; Aach, John; Church, George M

2015-02-18

Sequence-specific nucleases such as TALEN and the CRISPR/Cas9 system have so far been used to disrupt, correct or insert transgenes at precise locations in mammalian genomes. We demonstrate efficient 'knock-in' targeted replacement of multi-kilobase genes in human induced pluripotent stem cells (iPSC). Using a model system replacing endogenous human genes with their mouse counterpart, we performed a comprehensive study of targeting vector design parameters for homologous recombination. A 2.7 kilobase (kb) homozygous gene replacement was achieved in up to 11% of iPSC without selection. The optimal homology arm length was around 2 kb, with homology length being especially critical on the arm not adjacent to the cut site. Homologous sequence inside the cut sites was detrimental to targeting efficiency, consistent with a synthesis-dependent strand annealing (SDSA) mechanism. Using two nuclease sites, we observed a high degree of gene excisions and inversions, which sometimes occurred more frequently than indel mutations. While homozygous deletions of 86 kb were achieved with up to 8% frequency, deletion frequencies were not solely a function of nuclease activity and deletion size. Our results analyzing the optimal parameters for targeting vector design will inform future gene targeting efforts involving multi-kilobase gene segments, particularly in human iPSC. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

Linear transform of the multi-target survival curve

Energy Technology Data Exchange (ETDEWEB)

Watson, J V [Cambridge Univ. (UK). Dept. of Clinical Oncology and Radiotherapeutics

1978-07-01

A completely linear transform of the multi-target survival curve is presented. This enables all data, including those on the shoulder region of the curve, to be analysed. The necessity to make a subjective assessment about which data points to exclude for conventional methods of analysis is, therefore, removed. The analysis has also been adapted to include a 'Pike-Alper' method of assessing dose modification factors. For the data cited this predicts compatibility with the hypothesis of a true oxygen 'dose-modification' whereas the conventional Pike-Alper analysis does not.

A Two-Bladed Teetering Hub configuration for the DTU 10 MW RWT: loads considerations

DEFF Research Database (Denmark)

Bergami, Leonardo; Aagaard Madsen, Helge; Rasmussen, Flemming

2014-01-01

study on an alternative downwind two-bladed rotor configuration. The study is based on a model representative of next generation multi-MW wind turbines: the DTU 10-MW Reference Wind Turbine (RWT). As a first design iteration, the aerodynamic characteristics of the original rotor are maintained......As the size of wind turbine rotors continuously grows, the need for innovative solutions that would yield to lighter rotor configurations becomes more urgent. Traditional wind turbine designs have favored the classic three-bladed upwind rotor configuration. This work presents instead a concept...... in load variations, and hence in fatigue damage, affects the turbine blades, shaft and tower, and originates from the aerodynamic unbalance on the rotor, as well as from aeroelastic interaction with the tower frequency. To mitigate the load amplification caused by the interaction between the tower...

TargetCrys: protein crystallization prediction by fusing multi-view features with two-layered SVM.

Science.gov (United States)

Hu, Jun; Han, Ke; Li, Yang; Yang, Jing-Yu; Shen, Hong-Bin; Yu, Dong-Jun

2016-11-01

The accurate prediction of whether a protein will crystallize plays a crucial role in improving the success rate of protein crystallization projects. A common critical problem in the development of machine-learning-based protein crystallization predictors is how to effectively utilize protein features extracted from different views. In this study, we aimed to improve the efficiency of fusing multi-view protein features by proposing a new two-layered SVM (2L-SVM) which switches the feature-level fusion problem to a decision-level fusion problem: the SVMs in the 1st layer of the 2L-SVM are trained on each of the multi-view feature sets; then, the outputs of the 1st layer SVMs, which are the "intermediate" decisions made based on the respective feature sets, are further ensembled by a 2nd layer SVM. Based on the proposed 2L-SVM, we implemented a sequence-based protein crystallization predictor called TargetCrys. Experimental results on several benchmark datasets demonstrated the efficacy of the proposed 2L-SVM for fusing multi-view features. We also compared TargetCrys with existing sequence-based protein crystallization predictors and demonstrated that the proposed TargetCrys outperformed most of the existing predictors and is competitive with the state-of-the-art predictors. The TargetCrys webserver and datasets used in this study are freely available for academic use at: http://csbio.njust.edu.cn/bioinf/TargetCrys .

Ultra-high vacuum target assembly for charged particle irradiations in the materials research field

International Nuclear Information System (INIS)

Bressers, J.; Cassanelli, G.; Cat, R. de; Kohnen, H.; Gherardi, G.

1978-01-01

A target assembly designed for ion irradiation and ion implantation experiments on different particle accelerators is described. It consists of a target chamber separated from the beam line by a thin metal window, thus allowing implantations to be carried out under ultra-high vacuum conditions. Homogeneous in-depth distribution of the implanted ion species is realized by rotating the target about an axis perpendicular to the ion beam (rocking). The target holder is driven by means of a stepping motor with a constant step angle and a rocking device controller containing the required rocking angle-dwell time relation. Ion beam homogeneity over a sufficiently large target area is arrived at by transforming the Gaussian beam intensity profile into a flat beam intensity distribution by means of an electrostatic ring lens. The beam intensity profile is monitored by means of a specially designed ion beam monitor based on the Nipkov disc principle. A toroidal beam current monitoring transformer continuously measures the total beam current. Beam scanners and current measuring collimators complete the beam analysing equipment

Design of a full scale model fuel assembly for full power production reactor flow excursion experiments

International Nuclear Information System (INIS)

Nash, C.A.; Blake, J.E.; Rush, G.C.

1990-01-01

A novel full scale production reactor fuel assembly model was designed and built to study thermal-hydraulic effects of postulated Savannah River Site (SRS) nuclear reactor accidents. The electrically heated model was constructed to simulate the unique annular concentric tube geometry of fuel assemblies in SRS nuclear production reactors. Several major design challenges were overcome in order to produce the prototypic geometry and thermal-hydraulic conditions. The two concentric heater tubes (total power over 6 MW and maximum heat flux of 3.5 MW/m 2 ) (1.1E+6 BTU/(ft 2 hr)) were designed to closely simulate the thermal characteristics of SRS uranium-aluminum nuclear fuel. The paper discusses the design of the model fuel assembly, which met requirements of maintaining prototypic geometric and hydraulic characteristics, and approximate thermal similarity. The model had a cosine axial power profile and the electrical resistance was compatible with the existing power supply. The model fuel assembly was equipped with a set of instruments useful for code analysis, and durable enough to survive a number of LOCA transients. These instruments were sufficiently responsive to record the response of the fuel assembly to the imposed transient

Experience with construction and assembly of V-1 nuclear power plant

International Nuclear Information System (INIS)

Prochazka, J.; Stepanek, S.; Drahy, J.

1981-01-01

The model is discussed of the constructions of the V-1 nuclear power plant at Jaslovske Bohunice with SKODA Trust fulfilling the role of the general supplier of the secondary part technology and the chief and special assembly contractor. The SKODA Trust mediated the Soviet supplies of technology, Soviet assembly and special assembly, and the mounting of the primary part according to Soviet projects. Plant start-up was safeguarded by the investor through Bohunice power plant staff and Soviet experts. The assembly of the primary circuit and the test assembly of reactor parts are described and the experience gained is discussed. The technological requirements are illustrated by the most important characteristics of the individual parts of the primary circuit. Also described are the design specifications of the 220 MW saturated steam turbine and the experience with its assembly and start-up. (B.S.)

Self-assembled silk sericin/poloxamer nanoparticles as nanocarriers of hydrophobic and hydrophilic drugs for targeted delivery

International Nuclear Information System (INIS)

Mandal, Biman B; Kundu, S C

2009-01-01

In recent times self-assembled micellar nanoparticles have been successfully employed in tissue engineering for targeted drug delivery applications. In this review, silk sericin protein from non-mulberry Antheraea mylitta tropical tasar silk cocoons was blended with pluronic F-127 and F-87 in the presence of solvents to achieve self-assembled micellar nanostructures capable of carrying both hydrophilic (FITC-inulin) and hydrophobic (anticancer drug paclitaxel) drugs. The fabricated nanoparticles were subsequently characterized for their size distribution, drug loading capability, cellular uptake and cytotoxicity. Nanoparticle sizes ranged between 100 and 110 nm in diameter as confirmed by dynamic light scattering. Rapid uptake of these particles into cells was observed in in vitro cellular uptake studies using breast cancer MCF-7 cells. In vitro cytotoxicity assay using paclitaxel-loaded nanoparticles against breast cancer cells showed promising results comparable to free paclitaxel drugs. Drug-encapsulated nanoparticle-induced apoptosis in MCF-7 cells was confirmed by FACS and confocal microscopic studies using Annexin V staining. Up-regulation of pro-apoptotic protein Bax, down-regulation of anti-apoptotic protein Bcl-2 and cleavage of regulatory protein PARP through Western blot analysis suggested further drug-induced apoptosis in cells. This study projects silk sericin protein as an alternative natural biomaterial for fabrication of self-assembled nanoparticles in the presence of poloxamer for successful delivery of both hydrophobic and hydrophilic drugs to target sites.

Self-assembled silk sericin/poloxamer nanoparticles as nanocarriers of hydrophobic and hydrophilic drugs for targeted delivery

Energy Technology Data Exchange (ETDEWEB)

Mandal, Biman B; Kundu, S C, E-mail: kundu@hijli.iitkgp.ernet.i [Department of Biotechnology, Indian Institute of Technology, Kharagpur 721302 (India)

2009-09-02

In recent times self-assembled micellar nanoparticles have been successfully employed in tissue engineering for targeted drug delivery applications. In this review, silk sericin protein from non-mulberry Antheraea mylitta tropical tasar silk cocoons was blended with pluronic F-127 and F-87 in the presence of solvents to achieve self-assembled micellar nanostructures capable of carrying both hydrophilic (FITC-inulin) and hydrophobic (anticancer drug paclitaxel) drugs. The fabricated nanoparticles were subsequently characterized for their size distribution, drug loading capability, cellular uptake and cytotoxicity. Nanoparticle sizes ranged between 100 and 110 nm in diameter as confirmed by dynamic light scattering. Rapid uptake of these particles into cells was observed in in vitro cellular uptake studies using breast cancer MCF-7 cells. In vitro cytotoxicity assay using paclitaxel-loaded nanoparticles against breast cancer cells showed promising results comparable to free paclitaxel drugs. Drug-encapsulated nanoparticle-induced apoptosis in MCF-7 cells was confirmed by FACS and confocal microscopic studies using Annexin V staining. Up-regulation of pro-apoptotic protein Bax, down-regulation of anti-apoptotic protein Bcl-2 and cleavage of regulatory protein PARP through Western blot analysis suggested further drug-induced apoptosis in cells. This study projects silk sericin protein as an alternative natural biomaterial for fabrication of self-assembled nanoparticles in the presence of poloxamer for successful delivery of both hydrophobic and hydrophilic drugs to target sites.

TargetNet: a web service for predicting potential drug-target interaction profiling via multi-target SAR models

Science.gov (United States)

Yao, Zhi-Jiang; Dong, Jie; Che, Yu-Jing; Zhu, Min-Feng; Wen, Ming; Wang, Ning-Ning; Wang, Shan; Lu, Ai-Ping; Cao, Dong-Sheng

2016-05-01

Drug-target interactions (DTIs) are central to current drug discovery processes and public health fields. Analyzing the DTI profiling of the drugs helps to infer drug indications, adverse drug reactions, drug-drug interactions, and drug mode of actions. Therefore, it is of high importance to reliably and fast predict DTI profiling of the drugs on a genome-scale level. Here, we develop the TargetNet server, which can make real-time DTI predictions based only on molecular structures, following the spirit of multi-target SAR methodology. Naïve Bayes models together with various molecular fingerprints were employed to construct prediction models. Ensemble learning from these fingerprints was also provided to improve the prediction ability. When the user submits a molecule, the server will predict the activity of the user's molecule across 623 human proteins by the established high quality SAR model, thus generating a DTI profiling that can be used as a feature vector of chemicals for wide applications. The 623 SAR models related to 623 human proteins were strictly evaluated and validated by several model validation strategies, resulting in the AUC scores of 75-100 %. We applied the generated DTI profiling to successfully predict potential targets, toxicity classification, drug-drug interactions, and drug mode of action, which sufficiently demonstrated the wide application value of the potential DTI profiling. The TargetNet webserver is designed based on the Django framework in Python, and is freely accessible at http://targetnet.scbdd.com.

TargetNet: a web service for predicting potential drug-target interaction profiling via multi-target SAR models.

Science.gov (United States)

Yao, Zhi-Jiang; Dong, Jie; Che, Yu-Jing; Zhu, Min-Feng; Wen, Ming; Wang, Ning-Ning; Wang, Shan; Lu, Ai-Ping; Cao, Dong-Sheng

2016-05-01

Drug-target interactions (DTIs) are central to current drug discovery processes and public health fields. Analyzing the DTI profiling of the drugs helps to infer drug indications, adverse drug reactions, drug-drug interactions, and drug mode of actions. Therefore, it is of high importance to reliably and fast predict DTI profiling of the drugs on a genome-scale level. Here, we develop the TargetNet server, which can make real-time DTI predictions based only on molecular structures, following the spirit of multi-target SAR methodology. Naïve Bayes models together with various molecular fingerprints were employed to construct prediction models. Ensemble learning from these fingerprints was also provided to improve the prediction ability. When the user submits a molecule, the server will predict the activity of the user's molecule across 623 human proteins by the established high quality SAR model, thus generating a DTI profiling that can be used as a feature vector of chemicals for wide applications. The 623 SAR models related to 623 human proteins were strictly evaluated and validated by several model validation strategies, resulting in the AUC scores of 75-100 %. We applied the generated DTI profiling to successfully predict potential targets, toxicity classification, drug-drug interactions, and drug mode of action, which sufficiently demonstrated the wide application value of the potential DTI profiling. The TargetNet webserver is designed based on the Django framework in Python, and is freely accessible at http://targetnet.scbdd.com .

Intracellular targeting of CD44+ cells with self-assembling, protein only nanoparticles.

Science.gov (United States)

Pesarrodona, Mireia; Ferrer-Miralles, Neus; Unzueta, Ugutz; Gener, Petra; Tatkiewicz, Witold; Abasolo, Ibane; Ratera, Imma; Veciana, Jaume; Schwartz, Simó; Villaverde, Antonio; Vazquez, Esther

2014-10-01

CD44 is a multifunctional cell surface protein involved in proliferation and differentiation, angiogenesis and signaling. The expression of CD44 is up-regulated in several types of human tumors and particularly in cancer stem cells, representing an appealing target for drug delivery in the treatment of cancer. We have explored here several protein ligands of CD44 for the construction of self-assembling modular proteins designed to bind and internalize target cells. Among five tested ligands, two of them (A5G27 and FNI/II/V) drive the formation of protein-only, ring-shaped nanoparticles of about 14 nm that efficiently bind and penetrate CD44(+) cells by an endosomal route. The potential of these newly designed nanoparticles is evaluated regarding the need of biocompatible nanostructured materials for drug delivery in CD44-linked conditions. Copyright © 2014 Elsevier B.V. All rights reserved.

Mixed PWR core loadings with inert matrix Pu-fuel assemblies

International Nuclear Information System (INIS)

Stanculescu, A.; Kasemeyer, U.; Paratte, J.-M.; Chawla, R.

1999-01-01

The most efficient way to enhance plutonium consumption in light water reactors is to eliminate the production of plutonium all together. This requirement leads to fuel concepts in which the uranium is replaced by an inert matrix. At PSI, studies have focused on employing ZrO 2 as inert matrix. Adding a burnable poison to such a fuel proves to be necessary. As a result of scoping studies, Er 2 O 3 was identified as the most suitable burnable poison material. The results of whole-core three-dimensional neutronics analyses indicated, for a present-day 1000 MW e pressurised water reactor, the feasibility of an asymptotic equilibrium four-batch cycle fuelled solely with the proposed PuO 2 -Er 2 O 3 -ZrO 2 inert matrix fuel (IMF). The present paper presents the results of more recent investigations related to 'real-life' situations, which call for transition configurations in which mixed IMF and UO 2 assembly loadings must be considered. To determine the influence of the introduction of IMF assemblies on the characteristics of a UO 2 -fuelled core, three-dimensional full-core calculations have been performed for a present-day 1000 MW e PWR containing up to 12 optimised IMF assemblies. (author)

Robotically Assembled Aerospace Structures: Digital Material Assembly using a Gantry-Type Assembler

Science.gov (United States)

Trinh, Greenfield; Copplestone, Grace; O'Connor, Molly; Hu, Steven; Nowak, Sebastian; Cheung, Kenneth; Jenett, Benjamin; Cellucci, Daniel

2017-01-01

This paper evaluates the development of automated assembly techniques for discrete lattice structures using a multi-axis gantry type CNC machine. These lattices are made of discrete components called "digital materials." We present the development of a specialized end effector that works in conjunction with the CNC machine to assemble these lattices. With this configuration we are able to place voxels at a rate of 1.5 per minute. The scalability of digital material structures due to the incremental modular assembly is one of its key traits and an important metric of interest. We investigate the build times of a 5x5 beam structure on the scale of 1 meter (325 parts), 10 meters (3,250 parts), and 30 meters (9,750 parts). Utilizing the current configuration with a single end effector, performing serial assembly with a globally fixed feed station at the edge of the build volume, the build time increases according to a scaling law of n4, where n is the build scale. Build times can be reduced significantly by integrating feed systems into the gantry itself, resulting in a scaling law of n3. A completely serial assembly process will encounter time limitations as build scale increases. Automated assembly for digital materials can assemble high performance structures from discrete parts, and techniques such as built in feed systems, parallelization, and optimization of the fastening process will yield much higher throughput.

Supramolecular Lego assembly towards three-dimensional multi-responsive hydrogels.

Science.gov (United States)

Ma, Chunxin; Li, Tiefeng; Zhao, Qian; Yang, Xuxu; Wu, Jingjun; Luo, Yingwu; Xie, Tao

2014-08-27

Inspired by the assembly of Lego toys, hydrogel building blocks with heterogeneous responsiveness are assembled utilizing macroscopic supramolecular recognition as the adhesion force. The Lego hydrogel provides 3D transformation upon pH variation. After disassembly of the building blocks by changing the oxidation state, they can be re-assembled into a completely new shape. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Overcoming the hurdles of multi-step targeting (MST) for effective radioimmunotherapy of solid tumors

International Nuclear Information System (INIS)

Larson, Steven M.; Cheung, Nai-Kong

2009-01-01

The 4 specific aims of this project are: (1) Optimization of MST to increase tumor uptake; (2) Antigen heterogeneity; (3) Characterization and reduction of renal uptake; and (4) Validation in vivo of optimized MST targeted therapy. This proposal focussed upon optimizing multistep immune targeting strategies for the treatment of cancer. Two multi-step targeting constructs were explored during this funding period: (1) anti-Tag-72 and (2) anti-GD2.

Preliminary analyses of Li jet flows for the IFMIF target

International Nuclear Information System (INIS)

Ida, Mizuho; Kato, Yoshio; Nakamura, Hideo; Maekawa, Hiroshi

1997-03-01

The characteristics of liquid lithium (Li) plane jet flowing along a concave wall were studied using a multi-dimensional numerical code, FLOW-3D, as part of the two-year conceptual design activity (CDA) of the International Fusion Materials Irradiation Facility (IFMIF) that started in February 1995. The IFMIF will provide high flux, high energy (∼14MeV) neutron irradiation field by deuteron-Li reaction in the Li jet target for testing and development of low-activation and damage-resistant fusion materials. The Li jet target flow at high-velocity (≤ 20m/s) in vacuum, and should adequately remove the intense deuteron beam power (≤ 10MW). The two-dimensional analyses on the thermal and hydraulic responses of the target flow, under the conditions proposed in the IFMIF-CDA, indicated enough temperature margins to avoid significant vaporization and voiding respectively at the jet free surface and the peak temperature location in the jet by keeping the flow stability. (author)

Status of construction and assembly of Wendelstein 7-X

International Nuclear Information System (INIS)

Hartmann, D.A.

2005-01-01

areas with radiative losses up to 100 kW/m 2 . Presently the target elements, the panels and the support structures are being manufactured. The ECR heating system will consist of 10 gyrotrons with an output power of 1 MW cw each, appropriate optical transmission lines and launching systems. The first two gyrotrons have been delivered and are being commissioned. One of them has already produced more than 800 kW high frequency power for more than 30 minutes. The assembly of the basic machine is expected to be completed in 2011, the final installation of the periphery, diagnostics and heating systems are planned for the same year so that commissioning can start and the first plasma is produced by the middle of 2012. (author)

Fuel assembly

International Nuclear Information System (INIS)

Ueda, Sei; Ando, Ryohei; Mitsutake, Toru.

1995-01-01

The present invention concerns a fuel assembly suitable to a BWR-type reactor and improved especially with the nuclear characteristic, heat performance, hydraulic performance, dismantling or assembling performance and economical property. A part of poison rods are formed as a large-diameter/multi-region poison rods having a larger diameter than a fuel rod. A large number of fuel rods are disposed surrounding a large diameter water rod and a group of the large-diameter/multi-region poison rods in adjacent with the water rod. The large-diameter water rod has a burnable poison at the tube wall portion. At least a portion of the large-diameter poison rods has a coolant circulation portion allowing coolants to circulate therethrough. Since the large-diameter poison rods are disposed at a position of high neutron fluxes, a large neutron multiplication factor suppression effect can be provided, thereby enabling to reduce the number of burnable poison rods relative to fuels. As a result, power peaking in the fuel assembly is moderated and a greater amount of plutonium can be loaded. In addition the flow of cooling water which tends to gather around the large diameter water rod can be controlled to improve cooling performance of fuels. (N.H.)

Targeted isolation, sequence assembly and characterization of two white spruce (Picea glauca BAC clones for terpenoid synthase and cytochrome P450 genes involved in conifer defence reveal insights into a conifer genome

Directory of Open Access Journals (Sweden)

Ritland Carol

2009-08-01

Full Text Available Abstract Background Conifers are a large group of gymnosperm trees which are separated from the angiosperms by more than 300 million years of independent evolution. Conifer genomes are extremely large and contain considerable amounts of repetitive DNA. Currently, conifer sequence resources exist predominantly as expressed sequence tags (ESTs and full-length (FLcDNAs. There is no genome sequence available for a conifer or any other gymnosperm. Conifer defence-related genes often group into large families with closely related members. The goals of this study are to assess the feasibility of targeted isolation and sequence assembly of conifer BAC clones containing specific genes from two large gene families, and to characterize large segments of genomic DNA sequence for the first time from a conifer. Results We used a PCR-based approach to identify BAC clones for two target genes, a terpene synthase (3-carene synthase; 3CAR and a cytochrome P450 (CYP720B4 from a non-arrayed genomic BAC library of white spruce (Picea glauca. Shotgun genomic fragments isolated from the BAC clones were sequenced to a depth of 15.6- and 16.0-fold coverage, respectively. Assembly and manual curation yielded sequence scaffolds of 172 kbp (3CAR and 94 kbp (CYP720B4 long. Inspection of the genomic sequences revealed the intron-exon structures, the putative promoter regions and putative cis-regulatory elements of these genes. Sequences related to transposable elements (TEs, high complexity repeats and simple repeats were prevalent and comprised approximately 40% of the sequenced genomic DNA. An in silico simulation of the effect of sequencing depth on the quality of the sequence assembly provides direction for future efforts of conifer genome sequencing. Conclusion We report the first targeted cloning, sequencing, assembly, and annotation of large segments of genomic DNA from a conifer. We demonstrate that genomic BAC clones for individual members of multi-member gene

Targeted isolation, sequence assembly and characterization of two white spruce (Picea glauca) BAC clones for terpenoid synthase and cytochrome P450 genes involved in conifer defence reveal insights into a conifer genome.

Science.gov (United States)

Hamberger, Björn; Hall, Dawn; Yuen, Mack; Oddy, Claire; Hamberger, Britta; Keeling, Christopher I; Ritland, Carol; Ritland, Kermit; Bohlmann, Jörg

2009-08-06

Conifers are a large group of gymnosperm trees which are separated from the angiosperms by more than 300 million years of independent evolution. Conifer genomes are extremely large and contain considerable amounts of repetitive DNA. Currently, conifer sequence resources exist predominantly as expressed sequence tags (ESTs) and full-length (FL)cDNAs. There is no genome sequence available for a conifer or any other gymnosperm. Conifer defence-related genes often group into large families with closely related members. The goals of this study are to assess the feasibility of targeted isolation and sequence assembly of conifer BAC clones containing specific genes from two large gene families, and to characterize large segments of genomic DNA sequence for the first time from a conifer. We used a PCR-based approach to identify BAC clones for two target genes, a terpene synthase (3-carene synthase; 3CAR) and a cytochrome P450 (CYP720B4) from a non-arrayed genomic BAC library of white spruce (Picea glauca). Shotgun genomic fragments isolated from the BAC clones were sequenced to a depth of 15.6- and 16.0-fold coverage, respectively. Assembly and manual curation yielded sequence scaffolds of 172 kbp (3CAR) and 94 kbp (CYP720B4) long. Inspection of the genomic sequences revealed the intron-exon structures, the putative promoter regions and putative cis-regulatory elements of these genes. Sequences related to transposable elements (TEs), high complexity repeats and simple repeats were prevalent and comprised approximately 40% of the sequenced genomic DNA. An in silico simulation of the effect of sequencing depth on the quality of the sequence assembly provides direction for future efforts of conifer genome sequencing. We report the first targeted cloning, sequencing, assembly, and annotation of large segments of genomic DNA from a conifer. We demonstrate that genomic BAC clones for individual members of multi-member gene families can be isolated in a gene-specific fashion. The

Multi-target camera tracking, hand-off and display LDRD 158819 final report

International Nuclear Information System (INIS)

Anderson, Robert J.

2014-01-01

Modern security control rooms gather video and sensor feeds from tens to hundreds of cameras. Advanced camera analytics can detect motion from individual video streams and convert unexpected motion into alarms, but the interpretation of these alarms depends heavily upon human operators. Unfortunately, these operators can be overwhelmed when a large number of events happen simultaneously, or lulled into complacency due to frequent false alarms. This LDRD project has focused on improving video surveillance-based security systems by changing the fundamental focus from the cameras to the targets being tracked. If properly integrated, more cameras shouldn't lead to more alarms, more monitors, more operators, and increased response latency but instead should lead to better information and more rapid response times. For the course of the LDRD we have been developing algorithms that take live video imagery from multiple video cameras, identifies individual moving targets from the background imagery, and then displays the results in a single 3D interactive video. In this document we summarize the work in developing this multi-camera, multi-target system, including lessons learned, tools developed, technologies explored, and a description of current capability.

Multi-target camera tracking, hand-off and display LDRD 158819 final report

Energy Technology Data Exchange (ETDEWEB)

Anderson, Robert J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2014-10-01

Modern security control rooms gather video and sensor feeds from tens to hundreds of cameras. Advanced camera analytics can detect motion from individual video streams and convert unexpected motion into alarms, but the interpretation of these alarms depends heavily upon human operators. Unfortunately, these operators can be overwhelmed when a large number of events happen simultaneously, or lulled into complacency due to frequent false alarms. This LDRD project has focused on improving video surveillance-based security systems by changing the fundamental focus from the cameras to the targets being tracked. If properly integrated, more cameras shouldn't lead to more alarms, more monitors, more operators, and increased response latency but instead should lead to better information and more rapid response times. For the course of the LDRD we have been developing algorithms that take live video imagery from multiple video cameras, identifies individual moving targets from the background imagery, and then displays the results in a single 3D interactive video. In this document we summarize the work in developing this multi-camera, multi-target system, including lessons learned, tools developed, technologies explored, and a description of current capability.

Multi-Target Camera Tracking, Hand-off and Display LDRD 158819 Final Report

Energy Technology Data Exchange (ETDEWEB)

Anderson, Robert J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Robotic and Security Systems Dept.

2014-10-01

Modern security control rooms gather video and sensor feeds from tens to hundreds of cameras. Advanced camera analytics can detect motion from individual video streams and convert unexpected motion into alarms, but the interpretation of these alarms depends heavily upon human operators. Unfortunately, these operators can be overwhelmed when a large number of events happen simultaneously, or lulled into complacency due to frequent false alarms. This LDRD project has focused on improving video surveillance-based security systems by changing the fundamental focus from the cameras to the targets being tracked. If properly integrated, more cameras shouldn’t lead to more alarms, more monitors, more operators, and increased response latency but instead should lead to better information and more rapid response times. For the course of the LDRD we have been developing algorithms that take live video imagery from multiple video cameras, identify individual moving targets from the background imagery, and then display the results in a single 3D interactive video. In this document we summarize the work in developing this multi-camera, multi-target system, including lessons learned, tools developed, technologies explored, and a description of current capability.

A Shielding Analysis of Hot Cell for a 10 MW Research Reactor

International Nuclear Information System (INIS)

Alnajjar, Alaaddin; Park, Chang Je; Roh, Gyuhong; Lee, Byunchul

2013-01-01

In this paper, a shielding analysis has been performed for the hot cell in a 10 MW research reactor. Two kinds of shielding analysis code systems are used such as MCNPX2.7 and M-Shield7. The first one is Monte Carlo stochastic code and the second one is a deterministic point kernel code. The results are compared in this study. In order to obtain source term, the ORIGEN-S code is used for different kinds of source. Four kinds of sources are taken into consideration. From the simulation, it is also proposed that the proper thickness of shielding material and the maximum source capacity in the hot cell. This study shows preliminary analysis results of hot cell shielding for 10MW research reactor. Total four different source terms are considered such as spent fuel assembly, Ir-192, Mo-99, and I-131. For shielding material, general concrete, heavy concrete, and lead are used. MCNPX code is mainly used for a simplified hot cell model and the result are nearly consistent when compared with M-Shield code. Required shielding thickness and the hot cell capacity are also obtained for various criterion of surface dose rates

DANAERO MW: Final Report

DEFF Research Database (Denmark)

Troldborg, Niels; Bak, Christian; Aagaard Madsen, Helge

This report describes the results of the EUDP funded DANAERO MW II project carried out by DTU Wind Energy (formerly Risø DTU) and the industrial partners, LM Wind Power, Vestas Wind Systems A/S and Siemens Wind Power. An overview of the data available from the project as well as the results from...... analysis of the data is given with the main objective to explore in detail the influence of atmospheric and wake turbulence on MW turbine performance, loading and stability. Finally, validation and demonstration of simulation codes are carried out....

Multi-surface topography targeted plateau honing for the processing of cylinder liner surfaces of automotive engines

Science.gov (United States)

Lawrence, K. Deepak; Ramamoorthy, B.

2016-03-01

Cylinder bores of automotive engines are 'engineered' surfaces that are processed using multi-stage honing process to generate multiple layers of micro geometry for meeting the different functional requirements of the piston assembly system. The final processed surfaces should comply with several surface topographic specifications that are relevant for the good tribological performance of the engine. Selection of the process parameters in three stages of honing to obtain multiple surface topographic characteristics simultaneously within the specification tolerance is an important module of the process planning and is often posed as a challenging task for the process engineers. This paper presents a strategy by combining the robust process design and gray-relational analysis to evolve the operating levels of honing process parameters in rough, finish and plateau honing stages targeting to meet multiple surface topographic specifications on the final running surface of the cylinder bores. Honing experiments were conducted in three stages namely rough, finish and plateau honing on cast iron cylinder liners by varying four honing process parameters such as rotational speed, oscillatory speed, pressure and honing time. Abbott-Firestone curve based functional parameters (Rk, Rpk, Rvk, Mr1 and Mr2) coupled with mean roughness depth (Rz, DIN/ISO) and honing angle were measured and identified as the surface quality performance targets to be achieved. The experimental results have shown that the proposed approach is effective to generate cylinder liner surface that would simultaneously meet the explicit surface topographic specifications currently practiced by the industry.

Combinatorial support vector machines approach for virtual screening of selective multi-target serotonin reuptake inhibitors from large compound libraries.

Science.gov (United States)

Shi, Z; Ma, X H; Qin, C; Jia, J; Jiang, Y Y; Tan, C Y; Chen, Y Z

2012-02-01

Selective multi-target serotonin reuptake inhibitors enhance antidepressant efficacy. Their discovery can be facilitated by multiple methods, including in silico ones. In this study, we developed and tested an in silico method, combinatorial support vector machines (COMBI-SVMs), for virtual screening (VS) multi-target serotonin reuptake inhibitors of seven target pairs (serotonin transporter paired with noradrenaline transporter, H(3) receptor, 5-HT(1A) receptor, 5-HT(1B) receptor, 5-HT(2C) receptor, melanocortin 4 receptor and neurokinin 1 receptor respectively) from large compound libraries. COMBI-SVMs trained with 917-1951 individual target inhibitors correctly identified 22-83.3% (majority >31.1%) of the 6-216 dual inhibitors collected from literature as independent testing sets. COMBI-SVMs showed moderate to good target selectivity in misclassifying as dual inhibitors 2.2-29.8% (majority virtual hits correlate with the reported effects of their predicted targets. COMBI-SVM is potentially useful for searching selective multi-target agents without explicit knowledge of these agents. Copyright © 2011 Elsevier Inc. All rights reserved.

Galaxy And Mass Assembly (GAMA): the G02 field, Herschel-ATLAS target selection and Data Release 3 arXiv

CERN Document Server

Baldry, I.K.; Brown, M.J.I.; Robotham, A.S.G.; Driver, S.P.; Dunne, L.; Alpaslan, M.; Brough, S.; Cluver, M.E.; Eardley, E.; Farrow, D.J.; Heymans, C.; Hildebrandt, H.; Hopkins, A.M.; Kelvin, L.S.; Loveday, J.; Moffett, A.J.; Norberg, P.; Owers, M.S.; Taylor, E.N.; Wright, A.H.; Bamford, S.P.; Bland-Hawthorn, J.; Bourne, N.; Bremer, M.N.; Colless, M.; Conselice, C.J.; Croom, S.M.; Davies, L.J.M.; Foster, C.; Grootes, M.W.; Holwerda, B.W.; Jones, D.H.; Kafle, P.R.; Kuijken, K.; Lara-Lopez, M.A.; Lopez-Sanchez, A.R.; Meyer, M.J.; Phillipps, S.; Sutherland, W.J.; van Kampen, E.; Wilkins, S.M.

We describe data release 3 (DR3) of the Galaxy And Mass Assembly (GAMA) survey. The GAMA survey is a spectroscopic redshift and multi-wavelength photometric survey in three equatorial regions each of 60.0 deg^2 (G09, G12, G15), and two southern regions of 55.7 deg^2 (G02) and 50.6 deg^2 (G23). DR3 consists of: the first release of data covering the G02 region and of data on H-ATLAS sources in the equatorial regions; and updates to data on sources released in DR2. DR3 includes 154809 sources with secure redshifts across four regions. A subset of the G02 region is 95.5% redshift complete to r<19.8 over an area of 19.5 deg^2, with 20086 galaxy redshifts, that overlaps substantially with the XXL survey (X-ray) and VIPERS (redshift survey). In the equatorial regions, the main survey has even higher completeness (98.5%), and spectra for about 75% of H-ATLAS filler targets were also obtained. This filler sample extends spectroscopic redshifts, for probable optical counterparts to H-ATLAS sub-mm sources, to 0.8 ma...

Decorating multi-walled carbon nanotubes with quantum dots for construction of multi-color fluorescent nanoprobes

International Nuclear Information System (INIS)

Jia Nengqin; Lian Qiong; Tian Zhong; Yin Min; Che, Shouhui; Shen Hebai; Duan Xin; Jing Lihong; Gao Mingyuan

2010-01-01

Novel multi-color fluorescent nanoprobes were prepared by electrostatically assembling differently sized CdTe quantum dots on polyethylenimine (PEI) functionalized multi-walled carbon nanotubes (MWNTs). The structural and optical properties of the nano-assemblies (MWNTs-PEI-CdTe) were characterized by transmission electron microscopy (TEM), electron diffraction spectra (EDS), Raman spectroscopy, confocal microscopy and photoluminescence spectroscopy (PL), respectively. Electrochemical impedance spectroscopy (EIS) was also applied to investigate the electrostatic assembling among oxidized MWNTs, PEI and CdTe. Furthermore, confocal fluorescence microscopy was used to monitor the nano-assemblies' delivery into tumor cells. It was found that the nano-assemblies exhibit efficient intracellular transporting and strong intracellular tracking. These properties would make this luminescent nano-assembly an excellent building block for the construction of intracellular nanoprobes, which could hold great promise for biomedical applications.

CFD simulation of combustion in a 150 MW{sub e} CFB boiler

Energy Technology Data Exchange (ETDEWEB)

Zhang, Nan; Wang, Wei; Li, Jinghai [Chinese Academy of Sciences, Beijing (China). State Key Lab. of Multiphase Complex Systems

2013-07-01

Eulerian granular multiphase model with meso-scale modeling of drag coefficient and mass transfer coefficient, based on the energy minimization multi-scale (EMMS) model, was presented to simulate a 150 MW{sub e} CFB boiler. The three-dimensional (3D), time-dependent simulation results were presented in terms of the profiles of pressure, the distributions of carbon and oxygen, as well as the temperature. The EMMS-based sub-grid modeling allows using coarse grid with proven accuracy, and hence it is suitable for simulation of such large-scale industrial reactors.

Simulated nuclear reactor fuel assembly

International Nuclear Information System (INIS)

Berta, V.T.

1993-01-01

An apparatus for electrically simulating a nuclear reactor fuel assembly. It includes a heater assembly having a top end and a bottom end and a plurality of concentric heater tubes having electrical circuitry connected to a power source, and radially spaced from each other. An outer target tube and an inner target tube is concentric with the heater tubes and with each other, and the outer target tube surrounds and is radially spaced from the heater tubes. The inner target tube is surrounded by and radially spaced from the heater tubes and outer target tube. The top of the assembly is generally open to allow for the electrical power connection to the heater tubes, and the bottom of the assembly includes means for completing the electrical circuitry in the heater tubes to provide electrical resistance heating to simulate the power profile in a nuclear reactor. The embedded conductor elements in each heater tube is split into two halves for a substantial portion of its length and provided with electrical isolation such that each half of the conductor is joined at one end and is not joined at the other end

Improved genome-scale multi-target virtual screening via a novel collaborative filtering approach to cold-start problem.

Science.gov (United States)

Lim, Hansaim; Gray, Paul; Xie, Lei; Poleksic, Aleksandar

2016-12-13

Conventional one-drug-one-gene approach has been of limited success in modern drug discovery. Polypharmacology, which focuses on searching for multi-targeted drugs to perturb disease-causing networks instead of designing selective ligands to target individual proteins, has emerged as a new drug discovery paradigm. Although many methods for single-target virtual screening have been developed to improve the efficiency of drug discovery, few of these algorithms are designed for polypharmacology. Here, we present a novel theoretical framework and a corresponding algorithm for genome-scale multi-target virtual screening based on the one-class collaborative filtering technique. Our method overcomes the sparseness of the protein-chemical interaction data by means of interaction matrix weighting and dual regularization from both chemicals and proteins. While the statistical foundation behind our method is general enough to encompass genome-wide drug off-target prediction, the program is specifically tailored to find protein targets for new chemicals with little to no available interaction data. We extensively evaluate our method using a number of the most widely accepted gene-specific and cross-gene family benchmarks and demonstrate that our method outperforms other state-of-the-art algorithms for predicting the interaction of new chemicals with multiple proteins. Thus, the proposed algorithm may provide a powerful tool for multi-target drug design.

Thermal assessment of Shippingport pressurized water reactor blanket fuel assemblies within a multi-canister overpack within the canister storage building

International Nuclear Information System (INIS)

HEARD, F.J.

1999-01-01

A series of analyses were performed to assess the thermal performance characteristics of the Shippingport Pressurized Water Reactor Core 2 Blanket Fuel Assemblies as loaded within a Multi-Canister Overpack within the Canister Storage Building. A two-dimensional finite element was developed, with enough detail to model the individual fuel plates: including the fuel wafers, cladding, and flow channels

Thermal assessment of Shippingport pressurized water reactor blanket fuel assemblies within a multi-canister overpack within the canister storage building

Energy Technology Data Exchange (ETDEWEB)

HEARD, F.J.

1999-04-09

A series of analyses were performed to assess the thermal performance characteristics of the Shippingport Pressurized Water Reactor Core 2 Blanket Fuel Assemblies as loaded within a Multi-Canister Overpack within the Canister Storage Building. A two-dimensional finite element was developed, with enough detail to model the individual fuel plates: including the fuel wafers, cladding, and flow channels.

Exploring the evolutionary diversity and assembly modes of multi-aminoacyl-tRNA synthetase complexes: lessons from unicellular organisms.

Science.gov (United States)

Laporte, Daphné; Huot, Jonathan L; Bader, Gaétan; Enkler, Ludovic; Senger, Bruno; Becker, Hubert Dominique

2014-11-28

Aminoacyl-tRNA synthetases (aaRSs) are ubiquitous and ancient enzymes, mostly known for their essential role in generating aminoacylated tRNAs. During the last two decades, many aaRSs have been found to perform additional and equally crucial tasks outside translation. In metazoans, aaRSs have been shown to assemble, together with non-enzymatic assembly proteins called aaRSs-interacting multifunctional proteins (AIMPs), into so-called multi-synthetase complexes (MSCs). Metazoan MSCs are dynamic particles able to specifically release some of their constituents in response to a given stimulus. Upon their release from MSCs, aaRSs can reach other subcellular compartments, where they often participate to cellular processes that do not exploit their primary function of synthesizing aminoacyl-tRNAs. The dynamics of MSCs and the expansion of the aaRSs functional repertoire are features that are so far thought to be restricted to higher and multicellular eukaryotes. However, much can be learnt about how MSCs are assembled and function from apparently 'simple' organisms. Here we provide an overview on the diversity of these MSCs, their composition, mode of assembly and the functions that their constituents, namely aaRSs and AIMPs, exert in unicellular organisms. Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Biological evaluation and molecular docking of Rhein as a multi-targeted radiotherapy sensitization agent of nasopharyngeal carcinoma

Science.gov (United States)

Su, Zhengying; Tian, Wei; Li, Jing; Wang, Chunmiao; Pan, Zhiyu; Li, Danrong; Hou, Huaxin

2017-11-01

Radiation resistance of nasopharyngeal carcinoma (NPC) is a joint effect caused by complex molecular mechanisms. The development of multi-target radiotherapy sensitization agents offered a promising method for the treatment of NPC. In this work, the probability of Rhein to be a multi-target radiotherapy sensitization agent was explored through computer aid virtual screening by inverse docking study. In order to validate the accuracy of the computational results, radiotherapy sensitization of Rhein to NPC cells and its effects on the expression of target proteins were evaluated separately by CCK8 assay and Western blotting analysis. Our result demonstrated that Rhein possessed strong binding affinity with RAC1 and HSP90. No cytotoxic concentration of Rhein had radiosensitization effect on nasopharyngeal carcinoma CNE1 cells. After treatment with Rhein and 2Gy radiation, the expression of RAC1 upregulated and the expression of HSP90 down-regulated in cells. Based on the above data, Rhein is likely to become an attractive lead compound for the future design of multi-target radiotherapy sensitization agents.

Extrapolation of the FOM 1 MW free-electron maser to a multi-megawatt millimeter microwave source

NARCIS (Netherlands)

Caplan, M.; Valentini, M.; Verhoeven, A.; Urbanus, W.; Tulupov, A.

1997-01-01

A Free-Electron Maser is now under test at the FOM Institute (Rijnhuizen, Netherlands) with the goal of producing 1 MW long pulse to CW microwave output in the range 130-250 GHz with wall plug efficiencies of 60%. An extrapolated version of this device is proposed, which by scaling up beam current

A targeted nanoglobular contrast agent from host-guest self-assembly for MR cancer molecular imaging.

Science.gov (United States)

Zhou, Zhuxian; Han, Zhen; Lu, Zheng-Rong

2016-04-01

The clinical application of nanoparticular Gd(III) based contrast agents for tumor molecular MRI has been hindered by safety concerns associated with prolonged tissue retention, although they can produce strong tumor enhancement. In this study, a targeted well-defined cyclodextrin-based nanoglobular contrast agent was developed through self-assembly driven by host-guest interactions for safe and effective cancer molecular MRI. Multiple β-cyclodextrins attached POSS (polyhedral oligomeric silsesquioxane) nanoglobule was used as host molecule. Adamantane-modified macrocyclic Gd(III) contrast agent, cRGD (cyclic RGDfK peptide) targeting ligand and fluorescent probe was used as guest molecules. The targeted host-guest nanoglobular contrast agent cRGD-POSS-βCD-(DOTA-Gd) specifically bond to αvβ3 integrin in malignant 4T1 breast tumor and provided greater contrast enhancement than the corresponding non-targeted agent. The agent also provided significant fluorescence signal in tumor tissue. The histological analysis of the tumor tissue confirmed its specific and effective targeting to αvβ3 integrin. The targeted imaging agent has a potential for specific cancer molecular MR and fluorescent imaging. Copyright © 2016 Elsevier Ltd. All rights reserved.

EURISOL-DS Multi-MWatt Hg Target: Neutron flux and fission rate calculations for the MAFF configuration

CERN Document Server

Romanets, Y; Vaz, P; Herrera-Martinez, A; Kadi, Y; Kharoua, C; Lettry, J; Lindroos, M

The EURISOL (The EURopean Isotope Separation On-Line Radioactive Ion Beam) project aims at producing high intensity radioactive ion beams produced by neutron induced fission on a fissile target (235U) surrounding a liquid mercury converter. A proton beam of 1 GeV and 4 MW impinges on the Hg converter generating by spallation reactions high neutron fluxes. In this work the state-of-the-art Monte Carlo codes MCNPX and FLUKA were used to assess the neutronics performance of the system which geometry, inspired from the MAFF concept, allows a versatile manipulation of the fission targets. The objective of the study was to optimize the geometry of the system and the materials used in the fuel and reflector elements of the system, in order to achieve the highest possible fission rate.

Fabrication and testing of W7-X pre-series target elements

International Nuclear Information System (INIS)

Boscary, J; Boeswirth, B; Greuner, H; Grigull, P; Missirlian, M; Plankensteiner, A; Schedler, B; Friedrich, T; Schlosser, J; Streibl, B; Traxler, H

2007-01-01

The assembly of the highly-loaded target plates of the WENDELSTEIN 7-X (W7-X) divertor requires the fabrication of 890 target elements (TEs). The plasma facing material is made of CFC NB31 flat tiles bonded to a CuCrZr copper alloy water-cooled heat sink. The elements are designed to remove a stationary heat flux and power up to 10 MW m -2 and 100 kW, respectively. Before launching the serial fabrication, pre-series activities aimed at qualifying the design, the manufacturing route and the non-destructive examinations (NDEs). High heat flux (HHF) tests performed on full-scale pre-series TEs resulted in an improvement of the design of the bond between tiles and heat sink to reduce the stresses during operation. The consequence is the fabrication of additional pre-series TEs to be tested in the HHF facility GLADIS. NDEs of this bond based on thermography methods are developed to define the acceptance criteria suitable for serial fabrication

Recruitment and Consolidation of Cell Assemblies for Words by Way of Hebbian Learning and Competition in a Multi-Layer Neural Network.

Science.gov (United States)

Garagnani, Max; Wennekers, Thomas; Pulvermüller, Friedemann

2009-06-01

Current cognitive theories postulate either localist representations of knowledge or fully overlapping, distributed ones. We use a connectionist model that closely replicates known anatomical properties of the cerebral cortex and neurophysiological principles to show that Hebbian learning in a multi-layer neural network leads to memory traces (cell assemblies) that are both distributed and anatomically distinct. Taking the example of word learning based on action-perception correlation, we document mechanisms underlying the emergence of these assemblies, especially (i) the recruitment of neurons and consolidation of connections defining the kernel of the assembly along with (ii) the pruning of the cell assembly's halo (consisting of very weakly connected cells). We found that, whereas a learning rule mapping covariance led to significant overlap and merging of assemblies, a neurobiologically grounded synaptic plasticity rule with fixed LTP/LTD thresholds produced minimal overlap and prevented merging, exhibiting competitive learning behaviour. Our results are discussed in light of current theories of language and memory. As simulations with neurobiologically realistic neural networks demonstrate here spontaneous emergence of lexical representations that are both cortically dispersed and anatomically distinct, both localist and distributed cognitive accounts receive partial support.

Visualization of the Serratia Type VI Secretion System Reveals Unprovoked Attacks and Dynamic Assembly

Directory of Open Access Journals (Sweden)

Amy J. Gerc

2015-09-01

Full Text Available The Type VI secretion system (T6SS is a bacterial nanomachine that fires toxic proteins into target cells. Deployment of the T6SS represents an efficient and widespread means by which bacteria attack competitors or interact with host organisms and may be triggered by contact from an attacking neighbor cell as a defensive strategy. Here, we use the opportunist pathogen Serratia marcescens and functional fluorescent fusions of key components of the T6SS to observe different subassemblies of the machinery simultaneously and on multiple timescales in vivo. We report that the localization and dynamic behavior of each of the components examined is distinct, revealing a multi-stage and dynamic assembly process for the T6SS machinery. We also show that the T6SS can assemble and fire without needing a cell contact trigger, defining an aggressive strategy that broadens target range and suggesting that activation of the T6SS is tailored to survival in specific niches.

Visualization of the Serratia Type VI Secretion System Reveals Unprovoked Attacks and Dynamic Assembly

Science.gov (United States)

Gerc, Amy J.; Diepold, Andreas; Trunk, Katharina; Porter, Michael; Rickman, Colin; Armitage, Judith P.; Stanley-Wall, Nicola R.; Coulthurst, Sarah J.

2015-01-01

Summary The Type VI secretion system (T6SS) is a bacterial nanomachine that fires toxic proteins into target cells. Deployment of the T6SS represents an efficient and widespread means by which bacteria attack competitors or interact with host organisms and may be triggered by contact from an attacking neighbor cell as a defensive strategy. Here, we use the opportunist pathogen Serratia marcescens and functional fluorescent fusions of key components of the T6SS to observe different subassemblies of the machinery simultaneously and on multiple timescales in vivo. We report that the localization and dynamic behavior of each of the components examined is distinct, revealing a multi-stage and dynamic assembly process for the T6SS machinery. We also show that the T6SS can assemble and fire without needing a cell contact trigger, defining an aggressive strategy that broadens target range and suggesting that activation of the T6SS is tailored to survival in specific niches. PMID:26387948

EURISOL High Power Targets

CERN Document Server

Kadi, Y; Lindroos, M; Ridikas, D; Stora, T; Tecchio, L; CERN. Geneva. BE Department

2009-01-01

Modern Nuclear Physics requires access to higher yields of rare isotopes, that relies on further development of the In-flight and Isotope Separation On-Line (ISOL) production methods. The limits of the In-Flight method will be applied via the next generation facilities FAIR in Germany, RIKEN in Japan and RIBF in the USA. The ISOL method will be explored at facilities including ISAC-TRIUMF in Canada, SPIRAL-2 in France, SPES in Italy, ISOLDE at CERN and eventually at the very ambitious multi-MW EURISOL facility. ISOL and in-flight facilities are complementary entities. While in-flight facilities excel in the production of very short lived radioisotopes independently of their chemical nature, ISOL facilities provide high Radioisotope Beam (RIB) intensities and excellent beam quality for 70 elements. Both production schemes are opening vast and rich fields of nuclear physics research. In this article we will introduce the targets planned for the EURISOL facility and highlight some of the technical and safety cha...

Rayleigh-Taylor instability in multi-structured spherical targets

International Nuclear Information System (INIS)

Gupta, N.K.; Lawande, S.V.

1986-01-01

An eigenvalue equation for the exponential growth rate of the Rayleigh-Taylor instability is derived in spherical geometry. The free surface and jump boundary conditions are obtained from the eigenvalue equation. The eigenvalue equation is solved in the cases where the initial fluid density profile has a step function or exponential variation in space and analytical formulae for growth rate of the instability are obtained. The solutions for the step function are generalized for any number N of spherical zones forming an arbitrary fluid density profile. The results of the numerical calculations for N spherical zones are compared with the exact analytical results for exponential fluid density profile with N=10 and a good agreement is observed. The formalism is further used to study the effects of density gradients on Rayleigh-Taylor instability in spherical geometry. Also analytical formulae are presented for a particular case of N=3 and shell targets. The formalism developed here can be used to study the growth of the instability in present day multi-structured shell targets. (author)

Expertise about the request of the nuclear power plant Leibstadt for increasing the power to 3600 MW{sub th}; Gutachten zum Gesuch des Kernkraftwerks Leibstadt um Leistungserhoehung auf 3600 MW{sub th}

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-03-15

On July 31, 1992, the nuclear power plant Leibstadt AG (KKL) submitted a request for a modification of its operation license for increasing the reactor thermal power to 3600 MW. In its examination, the Federal Agency for the Safety of Nuclear Installations (HSK) investigated the effects of the power increase on reactor safety, especially on the safety criteria which can limit the power. In doing this, a distinction has to be made between normal operation, design incidents and out-of-design accidents. KKL is a boiling water reactor (BWR) with a current maximum thermal power of 3,138 MW with 648 fuel assemblies in the core. Since the start of operation in February 1984, the reactor has been continuously improved and now almost fulfils the present state-of-the-art of science and technology for BWRs. After some incidents during the early years, the plant shows a high level of availability. During the past 6 years some fuel assembly damage has cast a shadow on good operational experience, but until now the collective irradiation dose of the plant staff and the environment has remained mostly below legal limits, as well as for the release of radioactive materials to the atmosphere and to the Rhine River. Calculations of core loading with the fuel assemblies presently used at KKL have shown that the operation and safety limits of the reactor core can still be preserved with a thermal power of 3600 MW. For normal operation, no objection can be raised against the power increase. This increase, however, has to be carried out step-by-step in order to gain experience concerning plant behaviour. With the higher power rating, increased dose rates are expected on systems and components, in plant rooms and in the plant area, which also leads to increased dose rates to the staff and environment. This increase has to be estimated and, possibly, correction measures will have to be taken in order to reduce them. Especially to be monitored is the dose rate increase in the machine hall

Ablation mass features in multi-pulses femtosecond laser ablate molybdenum target

Science.gov (United States)

Zhao, Dongye; Gierse, Niels; Wegner, Julian; Pretzler, Georg; Oelmann, Jannis; Brezinsek, Sebastijan; Liang, Yunfeng; Neubauer, Olaf; Rasinski, Marcin; Linsmeier, Christian; Ding, Hongbin

2018-03-01

In this study, the ablation mass features related to reflectivity of bulk Molybdenum (Mo) were investigated by a Ti: Sa 6 fs laser pulse at central wavelength 790 nm. The ablated mass removal was determined using Confocal Microscopy (CM) technique. The surface reflectivity was calibrated and measured by a Lambda 950 spectrophotometer as well as a CCD camera during laser ablation. The ablation mass loss per pulse increase with the increasing of laser shots, meanwhile the surface reflectivity decrease. The multi-pulses (100 shots) ablation threshold of Mo was determined to be 0.15 J/cm2. The incubation coefficient was estimated as 0.835. The reflectivity change of the Mo target surface following multi-pulses laser ablation were studied as a function of laser ablation shots at various laser fluences from 1.07 J/cm2 to 36.23 J/cm2. The results of measured reflectivity indicate that surface reflectivity of Mo target has a significant decline in the first 3-laser pulses at the various fluences. These results are important for developing a quantitative analysis model for laser induced ablation and laser induced breakdown spectroscopy for the first wall diagnosis of EAST tokamak.

Tracking algorithms for multi-hexagonal assemblies (2D and 3D)

International Nuclear Information System (INIS)

Prabha, Hem; Marleau, Guy; Hébert, Alain

2014-01-01

Highlights: • We present the method of computations of 2D and 3D fluxes in hexagonal assemblies. • Computation of fluxes requires computation of track lengths. • Equations are developed (in 2D and 3D) and are implemented in a program HX7. • The program HX7 is implemented in the NXT module of the code DRAGON. • The tracks are plotted and fluxes are compared with the EXCELT module of DRAGON. - Abstract: Background: There has been a continuous effort to design new reactors and study these reactors under different conditions. Some of these reactors have fuel pins arranged in hexagonal pitch. To study these reactors, development of computational methods and computer codes is required. For this purpose, we have developed algorithms to track two dimensional and three dimensional cluster geometries. These algorithms have been implemented in a subprogram HX7, that is implemented in the code DRAGON (Version 3.06F) to compute neutron flux distributions in these systems. Methods: Computation of the neutron flux distribution requires solution of neutron transport equation. While solving this equation, by using Carlvik’s method of collision probabilities, computation of tracks in the hexagonal geometries is required. In this paper we present equations that we have developed for the computation of tracks in two dimensional (2D) and three dimensional (3D) multi-hexagonal assemblies (with two rotational orientations). These equations have been implemented in a subprogram HX7, to compute tracks in seven hexagonal assemblies. The subprogram HX7 has been implemented in the NXT module of the DRAGON code, where tracks in the pins are computed. Results: The results of our algorithms NXT(+HX7) have been compared with the results obtained by the EXCELT module of DRAGON (Version 3.06F). Conclusions: We find that all the fluxes in 2D and fluxes in the outer pin (3D) are converging to their 3rd decimal places, in both the modules EXCELT and NXT(+HX7). For other regions 3D fluxes

Multi-objective problem of the modified distributed parallel machine and assembly scheduling problem (MDPMASP) with eligibility constraints

Science.gov (United States)

Amallynda, I.; Santosa, B.

2017-11-01

This paper proposes a new generalization of the distributed parallel machine and assembly scheduling problem (DPMASP) with eligibility constraints referred to as the modified distributed parallel machine and assembly scheduling problem (MDPMASP) with eligibility constraints. Within this generalization, we assume that there are a set non-identical factories or production lines, each one with a set unrelated parallel machine with different speeds in processing them disposed to a single assembly machine in series. A set of different products that are manufactured through an assembly program of a set of components (jobs) according to the requested demand. Each product requires several kinds of jobs with different sizes. Beside that we also consider to the multi-objective problem (MOP) of minimizing mean flow time and the number of tardy products simultaneously. This is known to be NP-Hard problem, is important to practice, as the former criterions to reflect the customer's demand and manufacturer's perspective. This is a realistic and complex problem with wide range of possible solutions, we propose four simple heuristics and two metaheuristics to solve it. Various parameters of the proposed metaheuristic algorithms are discussed and calibrated by means of Taguchi technique. All proposed algorithms are tested by Matlab software. Our computational experiments indicate that the proposed problem and fourth proposed algorithms are able to be implemented and can be used to solve moderately-sized instances, and giving efficient solutions, which are close to optimum in most cases.

Identifying natural compounds as multi-target-directed ligands against Alzheimer's disease: an in silico approach.

Science.gov (United States)

Ambure, Pravin; Bhat, Jyotsna; Puzyn, Tomasz; Roy, Kunal

2018-04-23

Alzheimer's disease (AD) is a multi-factorial disease, which can be simply outlined as an irreversible and progressive neurodegenerative disorder with an unclear root cause. It is a major cause of dementia in old aged people. In the present study, utilizing the structural and biological activity information of ligands for five important and mostly studied vital targets (i.e. cyclin-dependant kinase 5, β-secretase, monoamine oxidase B, glycogen synthase kinase 3β, acetylcholinesterase) that are believed to be effective against AD, we have developed five classification models using linear discriminant analysis (LDA) technique. Considering the importance of data curation, we have given more attention towards the chemical and biological data curation, which is a difficult task especially in case of big data-sets. Thus, to ease the curation process we have designed Konstanz Information Miner (KNIME) workflows, which are made available at http://teqip.jdvu.ac.in/QSAR_Tools/ . The developed models were appropriately validated based on the predictions for experiment derived data from test sets, as well as true external set compounds including known multi-target compounds. The domain of applicability for each classification model was checked based on a confidence estimation approach. Further, these validated models were employed for screening of natural compounds collected from the InterBioScreen natural database ( https://www.ibscreen.com/natural-compounds ). Further, the natural compounds that were categorized as 'actives' in at least two classification models out of five developed models were considered as multi-target leads, and these compounds were further screened using the drug-like filter, molecular docking technique and then thoroughly analyzed using molecular dynamics studies. Finally, the most potential multi-target natural compounds against AD are suggested.

Multi-fuel multi-product operation of IGCC power plants with carbon capture and storage (CCS)

International Nuclear Information System (INIS)

Cormos, Ana-Maria; Dinca, Cristian; Cormos, Calin-Cristian

2015-01-01

This paper investigates multi-fuel multi-product operation of IGCC plants with carbon capture and storage (CCS). The investigated plant designs co-process coal with different sorts of biomass (e.g. sawdust) and solid wastes, through gasification, leading to different decarbonised energy vectors (power, hydrogen, heat, substitute natural gas etc.) simultaneous with carbon capture. Co-gasification of coal with different renewable energy sources coupled with carbon capture will pave the way towards zero emissions power plants. The energy conversions investigated in the paper were simulated using commercial process flow modelling package (ChemCAD) in order to produce mass and energy balances necessary for the proposed evaluation. As illustrative cases, hydrogen and power co-generation and Fischer–Tropsch fuel synthesis (both with carbon capture), were presented. The case studies investigated in the paper produce a flexible ratio between power and hydrogen (in the range of 400–600 MW net electricity and 0–200 MW th hydrogen considering the lower heating value) with at least 90% carbon capture rate. Special emphasis were given to fuel selection criteria for optimisation of gasification performances (fuel blending), to the selection criteria for gasification reactor in a multi-fuel multi-product operation scenario, modelling and simulation of whole process, to thermal and power integration of processes, flexibility analysis of the energy conversion processes, in-depth techno-economic and environmental assessment etc. - Highlights: • Assessment of IGCC-based energy vectors poly-generation systems with CCS. • Optimisation of gasification performances and CO 2 emissions by fuel blending. • Multi-fuel multi-product operation of gasification plants

Neutron flux measurement in the central channel (XC-1) of TRIGA 14 MW LEU core

International Nuclear Information System (INIS)

BARBOS, D.; BUSUIOC, P.; ROTH, Cs.; PAUNOIU, C.

2008-01-01

The TRIGA 14 MW reactor, operated by Institute for Nuclear Research Pitesti, Romania, is a pool type reactor, and has a rectangular shape which holds fuel bundles and is surrounded with beryllium reflectors. Each fuel bundle is composed of 25 nuclear fuel rods. The TRIGA 14 MW reactor was commissioned 28 years ago with HEU fuel rods. The conversion was gradually achieved, starting in February 1992 and completed in March 2006. The full conversion of the 14 MW TRIGA Research Reactor was completed in May 2006 and each step of the conversion was achieved by removal of HEU fuel, replaced by LEU fuel, accompanied by a large set of theoretical evaluation and physical measurements intended to confirm the performances of gradual conversion. After the core full conversion, a program of measurements and comparisons with previous results of core physics and measurements is underway, allowing data acquisition for normal operation, demonstration of safety and economics of the converted core. Neutron flux spectrum measurements in the XC in the XC-1 water 1 water-filled channel were performed using multi multi-foil activation techniques. The neutron spectra and flux are obtained by unfolding from measured reaction rates using SAND II computer code. The integral neutron flux value for LEU core is greater of 13% than for the standard HEU core. Also thermal neutron flux value for converted LEU core is smaller by 0.38% than for the standard HEU core. These differences appear because the foil activation detectors have been irradiated using a pneumatic rabbit having a diameter of 32 mm, whereas foil irradiations in standard HEU core has been performed with a pneumatic rabbit having a diameter of 14 mm, and therefore the neutron spectra in LEU core is less thermalized and the weight of fast neutron is greater

No-insulation multi-width winding technique for high temperature superconducting magnet.

Science.gov (United States)

Hahn, Seungyong; Kim, Youngjae; Keun Park, Dong; Kim, Kwangmin; Voccio, John P; Bascuñán, Juan; Iwasa, Yukikazu

2013-10-21

We present a No-Insulation ( NI ) Multi-Width ( MW ) winding technique for an HTS (high temperature superconductor) magnet consisting of double-pancake (DP) coils. The NI enables an HTS magnet self-protecting and the MW minimizes the detrimental anisotropy in current-carrying capacity of HTS tape by assigning tapes of multiple widths to DP coils within a stack, widest tape to the top and bottom sections and the narrowest in the midplane section. This paper presents fabrication and test results of an NI-MW HTS magnet and demonstrates the unique features of the NI-MW technique: self-protecting and enhanced field performance, unattainable with the conventional technique.

Inorganic nanocomposite films with polymer nanofillers made by the concurrent multi-beam multi-target pulsed laser deposition

Science.gov (United States)

Darwish, Abdalla M.; Sarkisov, Sergey S.; Mele, Paolo; Saini, Shrikant; Moore, Shaelynn; Bastian, Tyler; Dorlus, Wydglif; Zhang, Xiaodong; Koplitz, Brent

2017-08-01

We report on the new class of inorganic nanocomposite films with the inorganic phase hosting the polymer nanofillers made by the concurrent multi-beam multi-target pulsed laser deposition of the inorganic target material and matrix assisted pulsed laser evaporation of the polymer (MBMT-PLD/MAPLE). We used the exemplary nanocomposite thermoelectric films of aluminum-doped ZnO known as AZO with the nanofillers made of poly(methyl methacrylate) known as PMMA on various substrates such as SrTiO3, sapphire, fused silica, and polyimide. The AZO target was ablated with the second harmonic (532 nm) of the Nd:YAG Q-switched laser while PMMA was evaporated from its solution in chlorobenzene frozen in liquid nitrogen with the fundamental harmonic (1064 nm) of the same laser (50 Hz pulse repetition rate). The introduction of the polymer nanofillers increased the electrical conductivity of the nanocomposite films (possibly due to the carbonization of PMMA and the creation of additional channels of electric current) three times and reduced the thermal conductivity by 1.25 times as compared to the pure AZO films. Accordingly, the increase of the thermoelectric figure-of merit ZT would be 4 times. The best performance was observed for the sapphire substrates where the films were the most uniform. The results point to a huge potential of the optimization of a broad variety of optical, opto-electronic, and solar-power nanocomposite inorganic films by the controllable introduction of the polymer nanofillers using the MBMT-PLD/MAPLE method.

The Improved SVM Multi Objects' Identification For the Uncalibrated Visual Servoing

Directory of Open Access Journals (Sweden)

Min Wang

2009-03-01

Full Text Available For the assembly of multi micro objects in micromanipulation, the first task is to identify multi micro parts. We present an improved support vector machine algorithm, which employs invariant moments based edge extraction to obtain feature attribute and then presents a heuristic attribute reduction algorithm based on rough set's discernibility matrix to obtain attribute reduction, with using support vector machine to identify and classify the targets. The visual servoing is the second task. For avoiding the complicated calibration of intrinsic parameter of camera, We apply an improved broyden's method to estimate the image jacobian matrix online, which employs chebyshev polynomial to construct a cost function to approximate the optimization value, obtaining a fast convergence for online estimation. Last, a two DOF visual controller based fuzzy adaptive PD control law for micro-manipulation is presented. The experiments of micro-assembly of micro parts in microscopes confirm that the proposed methods are effective and feasible.

The Improved SVM Multi Objects's Identification for the Uncalibrated Visual Servoing

Directory of Open Access Journals (Sweden)

Xiangjin Zeng

2009-03-01

Full Text Available For the assembly of multi micro objects in micromanipulation, the first task is to identify multi micro parts. We present an improved support vector machine algorithm, which employs invariant moments based edge extraction to obtain feature attribute and then presents a heuristic attribute reduction algorithm based on rough set's discernibility matrix to obtain attribute reduction, with using support vector machine to identify and classify the targets. The visual servoing is the second task. For avoiding the complicated calibration of intrinsic parameter of camera, We apply an improved broyden's method to estimate the image jacobian matrix online, which employs chebyshev polynomial to construct a cost function to approximate the optimization value, obtaining a fast convergence for online estimation. Last, a two DOF visual controller based fuzzy adaptive PD control law for micro-manipulation is presented. The experiments of micro-assembly of micro parts in microscopes confirm that the proposed methods are effective and feasible.

Optimized swimmer tracking system based on a novel multi-related-targets approach

Science.gov (United States)

Benarab, D.; Napoléon, T.; Alfalou, A.; Verney, A.; Hellard, P.

2017-02-01

Robust tracking is a crucial step in automatic swimmer evaluation from video sequences. We designed a robust swimmer tracking system using a new multi-related-targets approach. The main idea is to consider the swimmer as a bloc of connected subtargets that advance at the same speed. If one of the subtargets is partially or totally occluded, it can be localized by knowing the position of the others. In this paper, we first introduce the two-dimensional direct linear transformation technique that we used to calibrate the videos. Then, we present the classical tracking approach based on dynamic fusion. Next, we highlight the main contribution of our work, which is the multi-related-targets tracking approach. This approach, the classical head-only approach and the ground truth are then compared, through testing on a database of high-level swimmers in training, national and international competitions (French National Championships, Limoges 2015, and World Championships, Kazan 2015). Tracking percentage and the accuracy of the instantaneous speed are evaluated and the findings show that our new appraoach is significantly more accurate than the classical approach.

Polyamine/salt-assembled microspheres coated with hyaluronic acid for targeting and pH sensing.

Science.gov (United States)

Zhang, Pan; Yang, Hui; Wang, Guojun; Tong, Weijun; Gao, Changyou

2016-06-01

The poly(allylamine hydrochloride)/trisodium citrate aggregates were fabricated and further covalently crosslinked via the coupling reaction of carboxylic sites on trisodium citrate with the amine groups on polyamine, onto which poly-L-lysine and hyaluronic acid were sequentially assembled, forming stable microspheres. The pH sensitive dye and pH insensitive dye were further labeled to enable the microspheres with pH sensing property. Moreover, these microspheres could be specifically targeted to HeLa tumor cells, since hyaluronic acid can specifically recognize and bind to CD44, a receptor overexpressed on many tumor cells. Quantitative pH measurement by confocal laser scanning microscopy demonstrated that the microspheres were internalized into HeLa cells, and accumulated in acidic compartments. By contrast, only a few microspheres were adhered on the NIH 3T3 cells surface. The microspheres with combined pH sensing property and targeting ability can enhance the insight understanding of the targeted drug vehicles trafficking after cellular internalization. Copyright © 2016 Elsevier B.V. All rights reserved.

Update on the modernization of 200 MW hard coal power plants in Poland

International Nuclear Information System (INIS)

Szabo, T.E.; Kopec, M.

1993-01-01

In June 1990, the Coalition of 200 MW, Hard Coal, Polish Power Plants representing an installed base of 10,240 MW, including 45 units of 200 MW, signed an agreement with the Westinghouse Electric Corporation, Power Generation Business Unit, based in Orlando, Florida, to cooperate on developing a modernization program for the 200 MW units. Program funding was obtained with The United States Trade Development Program (TDP) providing approximately 2/3 of the cost, and the balance provided by Westinghouse. On March 5, 1992, the Polish-American (51% Westinghouse, 49% Seven (7) Hard Coal Power Plants), Joint Venture Company, MODELPOL, Ltd. (Polish acronym for 'MODernizacja ELektrowni POLskich' or Modernization of Polish Power Plants) was established with the goal to implement not only technically but financially the recommendations of the Modernization Study. The mission given MODELPOL, Ltd. by their Polish-American Shareholders was to: develop the specific modernization programs for each hard coal power plant; assist in identifying and obtaining the financial resources required for implementation; and provide technological preventative maintenance services to improve unit availability. Within these aims was the target to reduce SO 2 , and particulate emissions. The first program is taking place at the Laziska Power Plant, followed by Rybnik. Further projects are in the planning stages. Finance is a constant problem, this should be eased by the restructuring of the power industry. Future programmes include connection to the European Community Power Grid. 5 figs

Computed isotopic inventory and dose assessment for SRS fuel and target assemblies

International Nuclear Information System (INIS)

Chandler, M.C.; Ketusky, E.T.; Thoman, D.C.

1995-01-01

Past studies have identified and evaluated important radionuclide contributors to dose from reprocessed spent fuel sent to waste for Mark 16B and 22 fuel assemblies and for Mark 31 A and 31B target assemblies. Fission-product distributions after a 5- and 15-year decay time were calculated for a ''representative'' set of irradiation conditions (i.e., reactor power, irradiation time, and exposure) for each type of assembly. The numerical calculations were performed using the SHIELD/GLASS system of codes. The sludge and supernate source terms for dose were studied separately with the significant radionuclide contributors for each identified and evaluated. Dose analysis considered both inhalation and ingestion pathways: The inhalation pathway was analyzed for both evaporative and volatile releases. Analysis of evaporative releases utilized release fractions for the individual radionuclides as defined in the ICRP-30 by DOE guidance. A release fraction of unity was assumed for each radionuclide under volatile-type releases, which would encompass internally initiated events (e.g., fires, explosions), process-initiated events, and externally initiated events. Radionuclides which contributed at least 1% to the overall dose were designated as significant contributors. The present analysis extends and complements the past analyses through considering a broader spectrum of fuel types and a wider range of irradiation conditions. The results provide for a more thorough understanding of the influences of fuel composition and irradiation parameters on fission product distributions (at 2 years or more). Additionally, the present work allows for a more comprehensive evaluation of radionuclide contributions to dose and an estimation of the variability in the radionuclide composition of the dose source term that results from the spent fuel sent to waste encompassing a broad spectrum of fuel compositions and irradiation conditions

Application of Advanced Multi-Core Processor Technologies to Oceanographic Research

Science.gov (United States)

2013-09-30

1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Application of Advanced Multi-Core Processor Technologies...STM32 NXP LPC series No Proprietary Microchip PIC32/DSPIC No > 500 mW; < 5 W ARM Cortex TI OMAP TI Sitara Broadcom BCM2835 Varies FPGA...state-of-the-art information processing architectures. OBJECTIVES Next-generation processor architectures (multi-core, multi-threaded) hold the

Planar ceramic membrane assembly and oxidation reactor system

Science.gov (United States)

Carolan, Michael Francis; Dyer, legal representative, Kathryn Beverly; Wilson, Merrill Anderson; Ohm, Ted R.; Kneidel, Kurt E.; Peterson, David; Chen, Christopher M.; Rackers, Keith Gerard; Dyer, deceased, Paul Nigel

2007-10-09

Planar ceramic membrane assembly comprising a dense layer of mixed-conducting multi-component metal oxide material, wherein the dense layer has a first side and a second side, a porous layer of mixed-conducting multi-component metal oxide material in contact with the first side of the dense layer, and a ceramic channeled support layer in contact with the second side of the dense layer. The planar ceramic membrane assembly can be used in a ceramic wafer assembly comprising a planar ceramic channeled support layer having a first side and a second side; a first dense layer of mixed-conducting multi-component metal oxide material having an inner side and an outer side, wherein the inner side is in contact with the first side of the ceramic channeled support layer; a first outer support layer comprising porous mixed-conducting multi-component metal oxide material and having an inner side and an outer side, wherein the inner side is in contact with the outer side of the first dense layer; a second dense layer of mixed-conducting multi-component metal oxide material having an inner side and an outer side, wherein the inner side is in contact with the second side of the ceramic channeled layer; and a second outer support layer comprising porous mixed-conducting multi-component metal oxide material and having an inner side and an outer side, wherein the inner side is in contact with the outer side of the second dense layer.

Four-dimensional characterization of inflow to and wakes from a multi-MW turbine: overview of the Turbine Wake and Inflow Characterization Study (TWICS2011)

Science.gov (United States)

Lundquist, J. K.; Banta, R. M.; Pichugina, Y.; Brewer, A.; Alvarez, R. J.; Sandberg, S. P.; Kelley, N. D.; Aitken, M.; Clifton, A.; Mirocha, J. D.

2011-12-01

To support substantial deployment of renewably-generated electricity from the wind, critical information about the variability of wind turbine wakes in the real atmosphere from multi-MW turbines is required. The assessment of the velocity deficit and turbulence associated with industrial-scale turbines is a major issue for wind farm design, particularly with respect to the optimization of the spacing between turbines. The significant velocity deficit and turbulence generated by upstream turbines can reduce the power production and produce harmful vibrations in downstream turbines, which can lead to excess maintenance costs. The complexity of wake effects depends on many factors arising from both hardware (turbine size, rotor speed, and blade geometry, etc.) and from meteorological considerations such as wind velocity, gradients of wind across the turbine rotor disk, atmospheric stability, and atmospheric turbulence. To characterize the relationships between the meteorological inflow and turbine wakes, a collaborative field campaign was designed and carried out at the Department of Energy's National Wind Technology Center (NREL/NWTC) in south Boulder, Colorado, in spring 2011. This site often experiences channeled flow with a consistent wind direction, enabling robust statistics of wake velocity deficits and turbulence enhancements. Using both in situ and remote sensing instrumentation, measurements upwind and downwind of multi-megawatt wind turbine in complex terrain quantified the variability of wind turbine inflow and wakes from an industrial-scale turbine. The turbine of interest has a rated power of 2.3 MW, a rotor diameter of 100m, and a hub height of 80m. In addition to several meteorological towers, one extending to hub height (80m) and another extending above the top of the rotor disk (135m), a Triton mini-sodar and a Windcube lidar characterized the inflow to the turbine and the variability across the site. The centerpiece instrument of the TWICS campaign

Combined analgesics in (headache pain therapy: shotgun approach or precise multi-target therapeutics?

Directory of Open Access Journals (Sweden)

Fiebich Bernd L

2011-03-01

Full Text Available Abstract Background Pain in general and headache in particular are characterized by a change in activity in brain areas involved in pain processing. The therapeutic challenge is to identify drugs with molecular targets that restore the healthy state, resulting in meaningful pain relief or even freedom from pain. Different aspects of pain perception, i.e. sensory and affective components, also explain why there is not just one single target structure for therapeutic approaches to pain. A network of brain areas ("pain matrix" are involved in pain perception and pain control. This diversification of the pain system explains why a wide range of molecularly different substances can be used in the treatment of different pain states and why in recent years more and more studies have described a superior efficacy of a precise multi-target combination therapy compared to therapy with monotherapeutics. Discussion In this article, we discuss the available literature on the effects of several fixed-dose combinations in the treatment of headaches and discuss the evidence in support of the role of combination therapy in the pharmacotherapy of pain, particularly of headaches. The scientific rationale behind multi-target combinations is the therapeutic benefit that could not be achieved by the individual constituents and that the single substances of the combinations act together additively or even multiplicatively and cooperate to achieve a completeness of the desired therapeutic effect. As an example the fixesd-dose combination of acetylsalicylic acid (ASA, paracetamol (acetaminophen and caffeine is reviewed in detail. The major advantage of using such a fixed combination is that the active ingredients act on different but distinct molecular targets and thus are able to act on more signalling cascades involved in pain than most single analgesics without adding more side effects to the therapy. Summary Multitarget therapeutics like combined analgesics broaden

Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics?

Science.gov (United States)

2011-01-01

Background Pain in general and headache in particular are characterized by a change in activity in brain areas involved in pain processing. The therapeutic challenge is to identify drugs with molecular targets that restore the healthy state, resulting in meaningful pain relief or even freedom from pain. Different aspects of pain perception, i.e. sensory and affective components, also explain why there is not just one single target structure for therapeutic approaches to pain. A network of brain areas ("pain matrix") are involved in pain perception and pain control. This diversification of the pain system explains why a wide range of molecularly different substances can be used in the treatment of different pain states and why in recent years more and more studies have described a superior efficacy of a precise multi-target combination therapy compared to therapy with monotherapeutics. Discussion In this article, we discuss the available literature on the effects of several fixed-dose combinations in the treatment of headaches and discuss the evidence in support of the role of combination therapy in the pharmacotherapy of pain, particularly of headaches. The scientific rationale behind multi-target combinations is the therapeutic benefit that could not be achieved by the individual constituents and that the single substances of the combinations act together additively or even multiplicatively and cooperate to achieve a completeness of the desired therapeutic effect. As an example the fixesd-dose combination of acetylsalicylic acid (ASA), paracetamol (acetaminophen) and caffeine is reviewed in detail. The major advantage of using such a fixed combination is that the active ingredients act on different but distinct molecular targets and thus are able to act on more signalling cascades involved in pain than most single analgesics without adding more side effects to the therapy. Summary Multitarget therapeutics like combined analgesics broaden the array of therapeutic

Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics?

Science.gov (United States)

Straube, Andreas; Aicher, Bernhard; Fiebich, Bernd L; Haag, Gunther

2011-03-31

Pain in general and headache in particular are characterized by a change in activity in brain areas involved in pain processing. The therapeutic challenge is to identify drugs with molecular targets that restore the healthy state, resulting in meaningful pain relief or even freedom from pain. Different aspects of pain perception, i.e. sensory and affective components, also explain why there is not just one single target structure for therapeutic approaches to pain. A network of brain areas ("pain matrix") are involved in pain perception and pain control. This diversification of the pain system explains why a wide range of molecularly different substances can be used in the treatment of different pain states and why in recent years more and more studies have described a superior efficacy of a precise multi-target combination therapy compared to therapy with monotherapeutics. In this article, we discuss the available literature on the effects of several fixed-dose combinations in the treatment of headaches and discuss the evidence in support of the role of combination therapy in the pharmacotherapy of pain, particularly of headaches. The scientific rationale behind multi-target combinations is the therapeutic benefit that could not be achieved by the individual constituents and that the single substances of the combinations act together additively or even multiplicatively and cooperate to achieve a completeness of the desired therapeutic effect.As an example the fixed-dose combination of acetylsalicylic acid (ASA), paracetamol (acetaminophen) and caffeine is reviewed in detail. The major advantage of using such a fixed combination is that the active ingredients act on different but distinct molecular targets and thus are able to act on more signalling cascades involved in pain than most single analgesics without adding more side effects to the therapy. Multitarget therapeutics like combined analgesics broaden the array of therapeutic options, enable the completeness

Multi-isocenter stereotactic radiotherapy: implications for target dose distributions of systematic and random localization errors

International Nuclear Information System (INIS)

Ebert, M.A.; Zavgorodni, S.F.; Kendrick, L.A.; Weston, S.; Harper, C.S.

2001-01-01

Purpose: This investigation examined the effect of alignment and localization errors on dose distributions in stereotactic radiotherapy (SRT) with arced circular fields. In particular, it was desired to determine the effect of systematic and random localization errors on multi-isocenter treatments. Methods and Materials: A research version of the FastPlan system from Surgical Navigation Technologies was used to generate a series of SRT plans of varying complexity. These plans were used to examine the influence of random setup errors by recalculating dose distributions with successive setup errors convolved into the off-axis ratio data tables used in the dose calculation. The influence of systematic errors was investigated by displacing isocenters from their planned positions. Results: For single-isocenter plans, it is found that the influences of setup error are strongly dependent on the size of the target volume, with minimum doses decreasing most significantly with increasing random and systematic alignment error. For multi-isocenter plans, similar variations in target dose are encountered, with this result benefiting from the conventional method of prescribing to a lower isodose value for multi-isocenter treatments relative to single-isocenter treatments. Conclusions: It is recommended that the systematic errors associated with target localization in SRT be tracked via a thorough quality assurance program, and that random setup errors be minimized by use of a sufficiently robust relocation system. These errors should also be accounted for by incorporating corrections into the treatment planning algorithm or, alternatively, by inclusion of sufficient margins in target definition

A Mw 6.3 earthquake scenario in the city of Nice (southeast France): ground motion simulations

Science.gov (United States)

Salichon, Jérome; Kohrs-Sansorny, Carine; Bertrand, Etienne; Courboulex, Françoise

2010-07-01

The southern Alps-Ligurian basin junction is one of the most seismically active zone of the western Europe. A constant microseismicity and moderate size events (3.5 case of an offshore Mw 6.3 earthquake located at the place where two moderate size events (Mw 4.5) occurred recently and where a morphotectonic feature has been detected by a bathymetric survey. We used a stochastic empirical Green’s functions (EGFs) summation method to produce a population of realistic accelerograms on rock and soil sites in the city of Nice. The ground motion simulations are calibrated on a rock site with a set of ground motion prediction equations (GMPEs) in order to estimate a reasonable stress-drop ratio between the February 25th, 2001, Mw 4.5, event taken as an EGF and the target earthquake. Our results show that the combination of the GMPEs and EGF techniques is an interesting tool for site-specific strong ground motion estimation.

15 MW HArdware-in-the-loop Grid Simulation Project

Energy Technology Data Exchange (ETDEWEB)

Rigas, Nikolaos [Clemson Univ., SC (United States); Fox, John Curtiss [Clemson Univ., SC (United States); Collins, Randy [Clemson Univ., SC (United States); Tuten, James [Clemson Univ., SC (United States); Salem, Thomas [Clemson Univ., SC (United States); McKinney, Mark [Clemson Univ., SC (United States); Hadidi, Ramtin [Clemson Univ., SC (United States); Gislason, Benjamin [Clemson Univ., SC (United States); Boessneck, Eric [Clemson Univ., SC (United States); Leonard, Jesse [Clemson Univ., SC (United States)

2014-10-31

The 15MW Hardware-in-the-loop (HIL) Grid Simulator project was to (1) design, (2) construct and (3) commission a state-of-the-art grid integration testing facility for testing of multi-megawatt devices through a ‘shared facility’ model open to all innovators to promote the rapid introduction of new technology in the energy market to lower the cost of energy delivered. The 15 MW HIL Grid Simulator project now serves as the cornerstone of the Duke Energy Electric Grid Research, Innovation and Development (eGRID) Center. This project leveraged the 24 kV utility interconnection and electrical infrastructure of the US DOE EERE funded WTDTF project at the Clemson University Restoration Institute in North Charleston, SC. Additionally, the project has spurred interest from other technology sectors, including large PV inverter and energy storage testing and several leading edge research proposals dealing with smart grid technologies, grid modernization and grid cyber security. The key components of the project are the power amplifier units capable of providing up to 20MW of defined power to the research grid. The project has also developed a one of a kind solution to performing fault ride-through testing by combining a reactive divider network and a large power converter into a hybrid method. This unique hybrid method of performing fault ride-through analysis will allow for the research team at the eGRID Center to investigate the complex differences between the alternative methods of performing fault ride-through evaluations and will ultimately further the science behind this testing. With the final goal of being able to perform HIL experiments and demonstration projects, the eGRID team undertook a significant challenge with respect to developing a control system that is capable of communicating with several different pieces of equipment with different communication protocols in real-time. The eGRID team developed a custom fiber optical network that is based upon FPGA

SWAP-Assembler: scalable and efficient genome assembly towards thousands of cores.

Science.gov (United States)

Meng, Jintao; Wang, Bingqiang; Wei, Yanjie; Feng, Shengzhong; Balaji, Pavan

2014-01-01

There is a widening gap between the throughput of massive parallel sequencing machines and the ability to analyze these sequencing data. Traditional assembly methods requiring long execution time and large amount of memory on a single workstation limit their use on these massive data. This paper presents a highly scalable assembler named as SWAP-Assembler for processing massive sequencing data using thousands of cores, where SWAP is an acronym for Small World Asynchronous Parallel model. In the paper, a mathematical description of multi-step bi-directed graph (MSG) is provided to resolve the computational interdependence on merging edges, and a highly scalable computational framework for SWAP is developed to automatically preform the parallel computation of all operations. Graph cleaning and contig extension are also included for generating contigs with high quality. Experimental results show that SWAP-Assembler scales up to 2048 cores on Yanhuang dataset using only 26 minutes, which is better than several other parallel assemblers, such as ABySS, Ray, and PASHA. Results also show that SWAP-Assembler can generate high quality contigs with good N50 size and low error rate, especially it generated the longest N50 contig sizes for Fish and Yanhuang datasets. In this paper, we presented a highly scalable and efficient genome assembly software, SWAP-Assembler. Compared with several other assemblers, it showed very good performance in terms of scalability and contig quality. This software is available at: https://sourceforge.net/projects/swapassembler.

Multibrid technology - a significant step to multi-megawatt wind turbines

Science.gov (United States)

Siegfriedsen, S.; Böhmeke, G.

1998-12-01

To fulfil the significant economic potential for offshore wind energy, it is essential that the largest possible installations must be allowed to come into use. Infrastructure investments for foundations and energy transport are only slightly dependent on the size of the installation, so these costs become proportionally smaller as the installed power output increases. This article puts forward a technologically novel type of development for a drive train design, specifically introduced for a 5 MW installation. The concept is especially suited for offshore application and the components are designed for this purpose. The usual way of modifying onshore plants partially and using them in the sea has been left with the present proposals. The design comprises a single-stage planetary gear, into which the rotor bearing is integrated, and a generator rotating at slow speed. Both components are assembled into a compact unit and are characterized by low wear and complete enclosure. New solutions are also proposed for the cooling of the machinery and the yaw system, offering particular advantages in offshore application. The advantages of the new technology are brought out from system comparisons with both a conventional plant configuration with a multi-stage gear and a high-speed generator, and also a combination with a direct drive generator in the 1·5 MW class. A particular design solution, worked through for a 5 MW installation, is presented and described in detail. At 31 kg kW-1, the specific tower head mass achieves a value that has not previously been realized in this power output class. As a result of the advantages that are brought together by this technology, both investment and operating costs are lowered, particularly for offshore applications. Implementation of this technology can thus provide a further stimulus for progress in wind energy utilization. Copyright

A network-based multi-target computational estimation scheme for anticoagulant activities of compounds.

Directory of Open Access Journals (Sweden)

Qian Li

Full Text Available BACKGROUND: Traditional virtual screening method pays more attention on predicted binding affinity between drug molecule and target related to a certain disease instead of phenotypic data of drug molecule against disease system, as is often less effective on discovery of the drug which is used to treat many types of complex diseases. Virtual screening against a complex disease by general network estimation has become feasible with the development of network biology and system biology. More effective methods of computational estimation for the whole efficacy of a compound in a complex disease system are needed, given the distinct weightiness of the different target in a biological process and the standpoint that partial inhibition of several targets can be more efficient than the complete inhibition of a single target. METHODOLOGY: We developed a novel approach by integrating the affinity predictions from multi-target docking studies with biological network efficiency analysis to estimate the anticoagulant activities of compounds. From results of network efficiency calculation for human clotting cascade, factor Xa and thrombin were identified as the two most fragile enzymes, while the catalytic reaction mediated by complex IXa:VIIIa and the formation of the complex VIIIa:IXa were recognized as the two most fragile biological matter in the human clotting cascade system. Furthermore, the method which combined network efficiency with molecular docking scores was applied to estimate the anticoagulant activities of a serial of argatroban intermediates and eight natural products respectively. The better correlation (r = 0.671 between the experimental data and the decrease of the network deficiency suggests that the approach could be a promising computational systems biology tool to aid identification of anticoagulant activities of compounds in drug discovery. CONCLUSIONS: This article proposes a network-based multi-target computational estimation

A network-based multi-target computational estimation scheme for anticoagulant activities of compounds.

Science.gov (United States)

Li, Qian; Li, Xudong; Li, Canghai; Chen, Lirong; Song, Jun; Tang, Yalin; Xu, Xiaojie

2011-03-22

Traditional virtual screening method pays more attention on predicted binding affinity between drug molecule and target related to a certain disease instead of phenotypic data of drug molecule against disease system, as is often less effective on discovery of the drug which is used to treat many types of complex diseases. Virtual screening against a complex disease by general network estimation has become feasible with the development of network biology and system biology. More effective methods of computational estimation for the whole efficacy of a compound in a complex disease system are needed, given the distinct weightiness of the different target in a biological process and the standpoint that partial inhibition of several targets can be more efficient than the complete inhibition of a single target. We developed a novel approach by integrating the affinity predictions from multi-target docking studies with biological network efficiency analysis to estimate the anticoagulant activities of compounds. From results of network efficiency calculation for human clotting cascade, factor Xa and thrombin were identified as the two most fragile enzymes, while the catalytic reaction mediated by complex IXa:VIIIa and the formation of the complex VIIIa:IXa were recognized as the two most fragile biological matter in the human clotting cascade system. Furthermore, the method which combined network efficiency with molecular docking scores was applied to estimate the anticoagulant activities of a serial of argatroban intermediates and eight natural products respectively. The better correlation (r = 0.671) between the experimental data and the decrease of the network deficiency suggests that the approach could be a promising computational systems biology tool to aid identification of anticoagulant activities of compounds in drug discovery. This article proposes a network-based multi-target computational estimation method for anticoagulant activities of compounds by

Secondary Cooling Water Quality Management for Multi Purpose Reactor 30 MW GA Siwabessy Indonesia

Energy Technology Data Exchange (ETDEWEB)

Sunaryo, Geni Rina, E-mail: genirina@batan.go.i [Center for Reactor Technology and Nuclear Safety (PTRKN-BATAN), Bldg. 80, Puspiptek Area, Serpong, Tangerang 15310 (Indonesia)

2011-07-01

Indonesia Multi Purpose Research Reactor (MPR) G.A. Siwabessy 30 MW will be 25 years old in 2011. Series of Non Destructive Test (NDT) were done to understand the current condition such as Eddy Current test for Heat Exchangers, water immersed camera for understanding the tank liner condition, ultrasonic for secondary piping etc. Some deteorization was observed because of ageing and some changing was done. One of them is changing some part of secondary pipe lines because of leaking, with the local ones. For having another 25 years operation life, a proper water quality for secondary cooling water is needed towards corrosion prevention. The main objectives of this experiment is to understand the current water quality of secondary cooling water of RSG-GAS from the aspect of corrosion induced by chemicals and bacteria, and establish procedure for managing the secondary cooling water quality. Methodologies applied are surveillance corrosion by immersing coupon into water observed and followed by visual analyses, corrosion rate determination by electrochemical method with various chemical conditions and total bacteria determination by using test kit. The results show visually that the crevice, galvanic and homogeny corrosion with the current water quality easily be observed for carbon steel represented secondary pipelines at the condition of none oxy bio agent addition. This corrosion is being suppressed by adding the oxy bio agent. The orientation of coupon, vertically and horizontally, gives slightly different effect. The closely corrosion rate was obtained by separately experiment, electrochemical, at the concentration of inhibitor 100ppm is 0.13 {+-} 0.02, which is lower than in the raw water of 0.20 {+-} 0.01 mpy. The total bacteria detected is around 10{sup 7} cfu/ml at none reactor operation and without any anti bacteria added. The oxi bio agent chemical addition suppresses the numbers becomes 10{sup 3} cfu/ml. The SRB bacteria is detected as >10{sup 6} cfu/ml at

The DIII-D 3 MW, 110 GHz ECH System

International Nuclear Information System (INIS)

Callis, R.W.; Lohr, J.; Ponce, D.; O'Neill, R.C.; Prater, R.; Luce, T.C.

1999-01-01

Three 110 GHz gyrotrons with nominal output power of 1 MW each have been installed and are operational on the DIII-D tokamak. One gyrotron is built by Gycom and has a nominal rating of 1 MW and a 2 s pulse length, with the pulse length being determined by the maximum temperature allowed on the edge cooled Boron Nitride window. The second and third gyrotrons were built by Communications and Power Industries (CPI). The first CPI gyrotron uses a double disc FC-75 cooled sapphire window which has a pulse length rating of 0.8 s at 1 MW, 2s at 0.5 MW and 10s at 0.35 MW. The second CPI gyrotron, utilizes a single disc chemical-vapor-deposition diamond window, that employs water cooling around the edge of the disc. Calculation predict that the diamond window should be capable of full 1 MW cw operation. All gyrotrons are connected to the tokamak by a low-loss-windowless evacuated transmission line using circular corrugated waveguide for propagation in the HEl 1 mode. Each waveguide system incorporates a two mirror launcher which can steer the rf beam poloidally from the center to the outer edge of the plasma. Central current drive experiments with the two gyrotrons with 1.5 MW of injected power drove about 0.17 MA. Results from using the three gyrotron systems will be reported as well as the plans to upgrade the system to 6 MW

Design and Testing of the Fusion Virtual Assembly System FVAS1.0

International Nuclear Information System (INIS)

Pengcheng Long; Songlin Liu; Yican Wu

2006-01-01

Virtual assembly (VA), utilizing virtual reality (VR) technologies to plan and evaluate assembly process, retains the benefits (time-saving, inexpensive and no hazardous) of VR technologies and conquers the shortcoming of physical prototypes, such as long circle, high cost, low precision, and so on. Presented in this paper is the Fusion Virtual Assembly System FVAS 1.0 that makes possible engineering application for assemblies of large-scale complex nuclear facilities. FVAS 1.0 is designed to support the planning, evaluation and demonstration of assembly process, and training assemblers, and to work on PC (personal computer) platform. In this paper, architecture and main features of FVAS are introduced firstly. Then, design of the key sections (such as collision detection, virtual roaming) are described in detail. Finally, some successful application cases are presented. To enhance the real-time performance for large-scale nuclear facilities simulation, a policy based on separation of display scene and collision detection scene has been adopted. The display scene can be predigested to reduce the time of scene refreshment, and the collision detection performance is greatly improved by using the mature interference check ability of commercial CAD systems. Convenient observation mechanism brings more practicability. So a multi-viewpoints roaming scheme has been utilized to facilitate users' assembly operation. Users can obtain much optical information from multiple angles by switching between multi-viewpoints. The ESAT superconducting tokamak is characterized by large volume, complicated constitution and high assembly precision, e.g. the strict precision requirement in the assembly for the three tori (the tori of vacuum vessel, thermal shield, and toroidal coil). FVAS 1.0 has succeeded in demonstrating the assembly process of ESAT components. Furthermore, FVAS 1.0 has been applied to evaluate FDS-I (Fusion-Driven Sub-critical system) concept from assembly point of

Data association approaches in bearings-only multi-target tracking

Science.gov (United States)

Xu, Benlian; Wang, Zhiquan

2008-03-01

According to requirements of time computation complexity and correctness of data association of the multi-target tracking, two algorithms are suggested in this paper. The proposed Algorithm 1 is developed from the modified version of dual Simplex method, and it has the advantage of direct and explicit form of the optimal solution. The Algorithm 2 is based on the idea of Algorithm 1 and rotational sort method, it combines not only advantages of Algorithm 1, but also reduces the computational burden, whose complexity is only 1/ N times that of Algorithm 1. Finally, numerical analyses are carried out to evaluate the performance of the two data association algorithms.

Improvements in nuclear fuel assembly cages

Energy Technology Data Exchange (ETDEWEB)

Eaton, C.W.; Seeley, T.A.; Ince, G.; Speakman, W.T.

1986-03-12

The fuel pin/guide tube supporting grids of an assembly cage for a multi pin fuel element or a reflector element for a stringer are mounted in the moderator sleeve by way of mounting assemblies engaged in grooves machined into the interior surface of the sleeve, each mounting assembly including a split ring which is assembled into its groove by being radially contracted, pushed along the sleeve into registry with the groove and allowed to radially expand. The split ring may carry burnable neutron absorber. The region of the sleeve between two adjacent grids may be of smaller internal diameter than the remainder of the sleeve.

Multi-Objective Optimization for Solid Amine CO2 Removal Assembly in Manned Spacecraft

Directory of Open Access Journals (Sweden)

Rong A

2017-07-01

Full Text Available Carbon Dioxide Removal Assembly (CDRA is one of the most important systems in the Environmental Control and Life Support System (ECLSS for a manned spacecraft. With the development of adsorbent and CDRA technology, solid amine is increasingly paid attention due to its obvious advantages. However, a manned spacecraft is launched far from the Earth, and its resources and energy are restricted seriously. These limitations increase the design difficulty of solid amine CDRA. The purpose of this paper is to seek optimal design parameters for the solid amine CDRA. Based on a preliminary structure of solid amine CDRA, its heat and mass transfer models are built to reflect some features of the special solid amine adsorbent, Polyethylenepolyamine adsorbent. A multi-objective optimization for the design of solid amine CDRA is discussed further in this paper. In this study, the cabin CO2 concentration, system power consumption and entropy production are chosen as the optimization objectives. The optimization variables consist of adsorption cycle time, solid amine loading mass, adsorption bed length, power consumption and system entropy production. The Improved Non-dominated Sorting Genetic Algorithm (NSGA-II is used to solve this multi-objective optimization and to obtain optimal solution set. A design example of solid amine CDRA in a manned space station is used to show the optimal procedure. The optimal combinations of design parameters can be located on the Pareto Optimal Front (POF. Finally, Design 971 is selected as the best combination of design parameters. The optimal results indicate that the multi-objective optimization plays a significant role in the design of solid amine CDRA. The final optimal design parameters for the solid amine CDRA can guarantee the cabin CO2 concentration within the specified range, and also satisfy the requirements of lightweight and minimum energy consumption.

The chaperonin-60 universal target is a barcode for bacteria that enables de novo assembly of metagenomic sequence data.

Science.gov (United States)

Links, Matthew G; Dumonceaux, Tim J; Hemmingsen, Sean M; Hill, Janet E

2012-01-01

Barcoding with molecular sequences is widely used to catalogue eukaryotic biodiversity. Studies investigating the community dynamics of microbes have relied heavily on gene-centric metagenomic profiling using two genes (16S rRNA and cpn60) to identify and track Bacteria. While there have been criteria formalized for barcoding of eukaryotes, these criteria have not been used to evaluate gene targets for other domains of life. Using the framework of the International Barcode of Life we evaluated DNA barcodes for Bacteria. Candidates from the 16S rRNA gene and the protein coding cpn60 gene were evaluated. Within complete bacterial genomes in the public domain representing 983 species from 21 phyla, the largest difference between median pairwise inter- and intra-specific distances ("barcode gap") was found from cpn60. Distribution of sequence diversity along the ∼555 bp cpn60 target region was remarkably uniform. The barcode gap of the cpn60 universal target facilitated the faithful de novo assembly of full-length operational taxonomic units from pyrosequencing data from a synthetic microbial community. Analysis supported the recognition of both 16S rRNA and cpn60 as DNA barcodes for Bacteria. The cpn60 universal target was found to have a much larger barcode gap than 16S rRNA suggesting cpn60 as a preferred barcode for Bacteria. A large barcode gap for cpn60 provided a robust target for species-level characterization of data. The assembly of consensus sequences for barcodes was shown to be a reliable method for the identification and tracking of novel microbes in metagenomic studies.

The Bare Critical Assembly of Natural Uranium and Heavy Water

Energy Technology Data Exchange (ETDEWEB)

Popovic, D [Boris Kidric Institute of Nuclear Sciences, Vinca, Belgrade (Yugoslavia)

1958-07-01

The first reactor built in Yugoslavia was the bare zero energy heavy water and natural uranium assembly at the Boris Kidric Institute of Nuclear Sciences, Belgrade. The reactor went critical on April 29, 1958. The possession of four tons of natural uranium metal and the temporary availability of seven tons of heavy water encouraged the staff of the Institute to build a critical assembly. A critical assembly was chosen, rather than high flux reactor, because the heavy water was available only temporarily. Besides, a 10 MW, enriched uranium, research reactor is being built at the same Institute and should be ready for operation late this year. It was supposed that the zero energy reactor would provide experience in carrying out critical experiments, operational experience with nuclear reactors, and the possibility for an extensive program in reactor physics. (author)

A target development program for beamhole spallation neutron sources in the megawatt range

Energy Technology Data Exchange (ETDEWEB)

Bauer, G.S.; Atchison, F. [Rutherford Appleton Laboratory, Oxon (United Kingdom)] [and others

1995-10-01

Spallation sources as an alternative to fission neutron sources have been operating successfully up to 160 kW of beam power. With the next generation of these facilities aiming at the medium power range between 0.5 and 5 MW, loads on the targets will be high enough to make present experience of little relevance. With the 0.6 MW continuous facility SINQ under construction, and a 5 MW pulsed facility (ESS) under study in Europe, a research and development program is about to be started which aimes at assessing the limits of stationary and moving solid targets and the feasibility and potential benefits of flowing liquid metal targets. Apart from theoretical work and examination of existing irradiated material, including used targets from ISIS, it is intended to take advantage of the SINQ solid rod target design to improve the relevant data base by building the target in such a way that individual rods can be equipped as irradiation capsules.

Experimental results and recent developments on the EU 2 MW 170 GHz coaxial cavity gyrotron for ITER

Directory of Open Access Journals (Sweden)

Thumm M. K.

2012-09-01

Full Text Available The European Gyrotron Consortium (EGYC is responsible for developing one set of 170 GHz mm-wave sources, in support of Europe’s contribution to ITER. The original plan of targeting a 2 MW coaxial gyrotron is currently under discussion, in view of essential delays and damages. This paper reports on the latest results and plans with regard to the two 2 MW gyrotron prototypes, the industrial prototype at CRPP’s CW test stand and a modular pre-prototype at KIT. The industrial prototype was delivered to CRPP end of September 2011 and reached an output power of 2 MW at an efficiency of 45 % and with good RF beam pattern, in only four days of short pulse RF test. These results validated all design changes made in reaction to the results of the experiments in 2008. On the fifth experimental day, an internal absorber broke, terminating any further experiment with this tube. In parallel, design and experimental activities at KIT went on, in particular featuring reduced stray radiation down to 4% of the RF power. Next years’ plans for the 2 MW modular pre-prototype foresee a stepwise increase of pulse length.

A 20 MW podded ship underwater electromagnetic signature - the alternative electric field; Signature electromagnetique sous-marine d'un paquebot de 20 MW a pods - le champ electrique alternatif

Energy Technology Data Exchange (ETDEWEB)

Lucas, B.; Henocq, H.; Rannou, C. [Delegation Generale pour l' Armement, DET/GESMA, 75 - Paris (France); Albert, Th.; Harpin, D. [ALSTOM Marine (France); Bourguet, S.; Guerin, P. [Institut de Recherche en Electrotechnique et Electronique de Nantes Atlantique, 44 (France)

2006-03-15

Today, electric podded propulsion is used for many ships, cruise liners and Navy vessels.This propulsion uses high currents in extremely low frequencies (ELFE); currents flow through electrical network, equipment and pods. These alternative currents could generate important underwater electromagnetic field. GESMA has to quantify the level of this field and its impact on the signature of this kind of ship. Then, GESMA carried out electromagnetic measurements using a multi-sensors underwater and autonomous facility named AMI. It was placed on the route of a 20 MW podded ship, at one hundred meters depth from the surface. Especially, AMI observed an alternative radiated electric field... (authors)

Ultra Clean 1.1MW High Efficiency Natural Gas Engine Powered System

Energy Technology Data Exchange (ETDEWEB)

Zurlo, James; Lueck, Steve

2011-08-31

Dresser, Inc. (GE Energy, Waukesha gas engines) will develop, test, demonstrate, and commercialize a 1.1 Megawatt (MW) natural gas fueled combined heat and power reciprocating engine powered package. This package will feature a total efficiency > 75% and ultra low CARB permitting emissions. Our modular design will cover the 1 – 6 MW size range, and this scalable technology can be used in both smaller and larger engine powered CHP packages. To further advance one of the key advantages of reciprocating engines, the engine, generator and CHP package will be optimized for low initial and operating costs. Dresser, Inc. will leverage the knowledge gained in the DOE - ARES program. Dresser, Inc. will work with commercial, regulatory, and government entities to help break down barriers to wider deployment of CHP. The outcome of this project will be a commercially successful 1.1 MW CHP package with high electrical and total efficiency that will significantly reduce emissions compared to the current central power plant paradigm. Principal objectives by phases for Budget Period 1 include: • Phase 1 – market study to determine optimum system performance, target first cost, lifecycle cost, and creation of a detailed product specification. • Phase 2 – Refinement of the Waukesha CHP system design concepts, identification of critical characteristics, initial evaluation of technical solutions, and risk mitigation plans. Background

Conceptual designs for 100-MW space radiators

International Nuclear Information System (INIS)

Prenger, F.C.; Sullivan, J.A.

1982-01-01

A description and comparison of heat rejection systems for multimegawatt space-based power supplies is given. Current concepts are described, and through a common performance parameter, these are compared with three advanced radiator concepts. The comparison is based on a power system that rejects 100 MW of heat while generating 10 MW of electrical power

Target-moderator-reflector optimization for JAERI 5 MW pulsed spallation neutron source

International Nuclear Information System (INIS)

Watanabe, Noboru; Teshigawara, Makoto; Kai, Tetsuya

1999-01-01

Optimization studies on the target-moderator-reflector neutronics for the projected intense pulsed-spallation-neutron-source in JAERI are reported. In order to obtain the highest possible performance of the source a new target-moderator-reflector system has been proposed and effects of various parameters, such as material and the shape/dimensions of the target, the profile/distribution of the proton beam, material and dimensions of the reflector, the coupling scheme of the target-moderator, moderator parameters, etc., on slow neutron performance and energy deposition in cryogenic moderators have extensively been studied by neutronic calculations. A cold neutron moderator for high-resolution together with high-intensity experiments has newly been proposed. It was found that, by adopting a flat target with a flat beam profile, the slow neutron intensities from the moderators could be rather insensitive to the target/beam dimensions, providing more flexibility to the engineering design of the target and the moderators. The moderator position relative to the target is another important issue to be optimized. It was confirmed that the proposed target-moderator-reflector layout made it possible to put all the moderators almost at the best position (It has not been possible so far), resulting in a higher performance. The predicted performance obtained with nearly optimized parameters was compared with those of similar projects in the world to justify the present concept. (author)

EFTF cobalt test assembly results

International Nuclear Information System (INIS)

Rawlins, J.A.; Wootan, D.W.; Carter, L.L.; Brager, H.R.; Schenter, R.E.

1988-01-01

A cobalt test assembly containing yttrium hydride pins for neutron moderation was irradiated in the Fast Flux Test Facility during Cycle 9A for 137.7 equivalent full power days at a power level fo 291 MW. The 36 test pins consisted of a batch of 32 pins containing cobalt metal to produce Co-60, and a set of 4 pins with europium oxide to produce Gd-153, a radioisotope used in detection of the bone disease Osteoporosis. Post-irradiation examination of the cobalt pins determined the Co-60 produced with an accuracy of about 5 %. The measured Co-60 spatially distributed concentrations were within 20 % of the calculated concentrations. The assembly average Co-60 measured activity was 4 % less than the calculated value. The europium oxide pins were gamma scanned for the europium isotopes Eu-152 and Eu-154 to an absolute accuracy of about 10 %. The measured europium radioisotpe anc Gd-153 concentrations were within 20 % of calculated values. In conclusion, the hydride assembly performed well and is an excellent vehicle for many Fast Flux Test Facility isotope production applications. The results also demonstrate that the calculational methods developed by the Westinghouse Hanford Company are very accurate. (author)

Yawing characteristics during slippage of the nacelle of a multi MW wind turbine

Science.gov (United States)

Kim, M.-G.; Dalhoff, P. H.; Gust, P.

2016-09-01

High aerodynamic yaw loads coupled with electrical failures in the wind turbine can result to a slippage of the nacelle, due to limited braking capabilities of the yaw system. A slippage on the other hand can lead to a mechanical malfunction of the yaw system. To analyse the yawing characteristics of a wind turbine during nacelle slippage situations, a detailed multibody system model of the yaw system has been developed and incorporated in a multibody system model of a wind turbine based on a 3.3 MW turbine. Extreme load cases which lead to a nacelle slippage have been simulated. The dynamics and loads on different wind turbine components are presented and discussed. First results show minimal load increases of the rotor torque and the bending moments of the blade root sections during slippage but unfavourable rotational speeds of the yaw drives.

Inverse design of multicomponent assemblies

Science.gov (United States)

Piñeros, William D.; Lindquist, Beth A.; Jadrich, Ryan B.; Truskett, Thomas M.

2018-03-01

Inverse design can be a useful strategy for discovering interactions that drive particles to spontaneously self-assemble into a desired structure. Here, we extend an inverse design methodology—relative entropy optimization—to determine isotropic interactions that promote assembly of targeted multicomponent phases, and we apply this extension to design interactions for a variety of binary crystals ranging from compact triangular and square architectures to highly open structures with dodecagonal and octadecagonal motifs. We compare the resulting optimized (self- and cross) interactions for the binary assemblies to those obtained from optimization of analogous single-component systems. This comparison reveals that self-interactions act as a "primer" to position particles at approximately correct coordination shell distances, while cross interactions act as the "binder" that refines and locks the system into the desired configuration. For simpler binary targets, it is possible to successfully design self-assembling systems while restricting one of these interaction types to be a hard-core-like potential. However, optimization of both self- and cross interaction types appears necessary to design for assembly of more complex or open structures.

Latest Results in SLAC 75-MW PPM Klystrons

International Nuclear Information System (INIS)

Sprehn, D.; Caryotakis, G.; Haase, A.; Jongewaard, E.; Laurent, L.; Pearson, C.; Phillips, R.

2006-01-01

75 MW X-band klystrons utilizing Periodic Permanent Magnet (PPM) focusing have been undergoing design, fabrication and testing at the Stanford Linear Accelerator Center (SLAC) for almost nine years. The klystron development has been geared toward realizing the necessary components for the construction of the Next Linear Collider (NLC). The PPM devices built to date which fit this class of operation consist of a variety of 50 MW and 75 MW devices constructed by SLAC, KEK (Tsukuba, Japan) and industry. All these tubes follow from the successful SLAC design of a 50 MW PPM klystron in 1996. In 2004 the latest two klystrons were constructed and tested with preliminary results reported at EPAC2004. The first of these two devices was tested to the full NLC specifications of 75 MW, 1.6 microseconds pulse length, and 120 Hz. This 14.4 kW average power operation came with a tube efficiency >50%. The most recent testing of these last two devices will be presented here. Design and manufacturing issues of the latest klystron, due to be tested by the Fall of 2005, are also discussed

Multi-image mosaic with SIFT and vision measurement for microscale structures processed by femtosecond laser

Science.gov (United States)

Wang, Fu-Bin; Tu, Paul; Wu, Chen; Chen, Lei; Feng, Ding

2018-01-01

In femtosecond laser processing, the field of view of each image frame of the microscale structure is extremely small. In order to obtain the morphology of the whole microstructure, a multi-image mosaic with partially overlapped regions is required. In the present work, the SIFT algorithm for mosaic images was analyzed theoretically, and by using multiple images of a microgroove structure processed by femtosecond laser, a stitched image of the whole groove structure could be studied experimentally and realized. The object of our research concerned a silicon wafer with a microgroove structure ablated by femtosecond laser. First, we obtained microgrooves at a width of 380 μm at different depths. Second, based on the gray image of the microgroove, a multi-image mosaic with slot width and slot depth was realized. In order to improve the image contrast between the target and the background, and taking the slot depth image as an example, a multi-image mosaic was then realized using pseudo color enhancement. Third, in order to measure the structural size of the microgroove with the image, a known width streak ablated by femtosecond laser at 20 mW was used as a calibration sample. Through edge detection, corner extraction, and image correction for the streak images, we calculated the pixel width of the streak image and found the measurement ratio constant Kw in the width direction, and then obtained the proportional relationship between a pixel and a micrometer. Finally, circular spot marks ablated by femtosecond laser at 2 mW and 15 mW were used as test images, and proving that the value Kw was correct, the measurement ratio constant Kh in the height direction was obtained, and the image measurements for a microgroove of 380 × 117 μm was realized based on a measurement ratio constant Kw and Kh. The research and experimental results show that the image mosaic, image calibration, and geometric image parameter measurements for the microstructural image ablated by

IHEP S-band 45 MW pulse power klystron development

International Nuclear Information System (INIS)

Dong Dong; Zhou Zusheng; Zhang Liang; Li Gangying; Tian Shuangmin

2006-01-01

S-band 45 MW pulse power klystron has been developed in the Institute of High Energy Physics (IHEP) for the Beijing Electron Positron Collider (BEPC) upgrade projects (BEPC-II). This new klystron has 5 cavities in its RF-beam interaction and single RF output window, and the RF output power is 45 MW at 310 kV, the gain is 50 dB, the efficiency 40%. The manufacturing, training and testing of a prototype klystron has been finished in IHEP and RF power 45 MW at 300 kV has been reached. The testing results show that all the parameters of the 45 MW klystron reach the design goal. (authors)

Optimizing Transcriptome Assemblies for Eleusine indica Leaf and Seedling by Combining Multiple Assemblies from Three De Novo Assemblers

Directory of Open Access Journals (Sweden)

Shu Chen

2015-03-01

Full Text Available Due to rapid advances in sequencing technology, increasing amounts of genomic and transcriptomic data are available for plant species, presenting enormous challenges for biocomputing analysis. A crucial first step for a successful transcriptomics-based study is the building of a high-quality assembly. Here, we utilized three different de novo assemblers (Trinity, Velvet, and CLC and the EvidentialGene pipeline tr2aacds to assemble two optimized transcript sets for the notorious weed species, . Two RNA sequencing (RNA-seq datasets from leaf and aboveground seedlings were processed using three assemblers, which resulted in 20 assemblies for each dataset. The contig numbers and N50 values of each assembly were compared to study the effect of read number, k-mer size, and in silico normalization on assembly output. The 20 assemblies were then processed through the tr2aacds pipeline to remove redundant transcripts and to select the transcript set with the best coding potential. Each assembly contributed a considerable proportion to the final transcript combination with the exception of the CLC-k14. Thus each assembler and parameter set did assemble better contigs for certain transcripts. The redundancy, total contig number, N50, fully assembled contig number, and transcripts related to target-site herbicide resistance were evaluated for the EvidentialGene and Trinity assemblies. Comparing the EvidentialGene set with the Trinity assembly revealed improved quality and reduced redundancy in both leaf and seedling EvidentialGene sets. The optimized transcriptome references will be useful for studying herbicide resistance in and the evolutionary process in the three allotetraploid offspring.

Self-assembling complexes of quantum dots and scFv antibodies for cancer cell targeting and imaging.

Directory of Open Access Journals (Sweden)

Tatiana A Zdobnova

Full Text Available Semiconductor quantum dots represent a novel class of fluorophores with unique physical and chemical properties which could enable a remarkable broadening of the current applications of fluorescent imaging and optical diagnostics. Complexes of quantum dots and antibodies are promising visualising agents for fluorescent detection of selective biomarkers overexpressed in tumor tissues. Here we describe the construction of self-assembling fluorescent complexes of quantum dots and anti-HER1 or anti-HER2/neu scFv antibodies and their interactions with cultured tumor cells. A binding strategy based on a very specific non-covalent interaction between two proteins, barnase and barstar, was used to connect quantum dots and the targeting antibodies. Such a strategy allows combining the targeting and visualization functions simply by varying the corresponding modules of the fluorescent complex.

Self-assembled Multifunctional DNA Nanoflowers for the Circumvention of Multidrug Resistance in Targeted Anticancer Drug Delivery.

Science.gov (United States)

Mei, Lei; Zhu, Guizhi; Qiu, Liping; Wu, Cuichen; Chen, Huapei; Liang, Hao; Cansiz, Sena; Lv, Yifan; Zhang, Xiaobing; Tan, Weihong

2015-11-01

Cancer chemotherapy has been impeded by side effects and multidrug resistance (MDR) partially caused by drug efflux from cancer cells, which call for targeted drug delivery systems additionally able to circumvent MDR. Here we report multifunctional DNA nanoflowers (NFs) for targeted drug delivery to both chemosensitive and MDR cancer cells and circumvent MDR in both leukemia and breast cancer cell models. NFs are self-assembled via liquid crystallization of DNA generated by Rolling Circle Replication, during which NFs are incorporated with aptamers for specific cancer cell recognition, fluorophores for bioimaging, and Doxorubicin (Dox)-binding DNA for drug delivery. NF sizes are tunable (down to ~200 nm in diameter), and the densely packed drug-binding motifs and porous intrastructures endow NFs with high drug loading capacity (71.4%, wt/wt). The Dox-loaded NFs (NF-Dox) are stable at physiological pH, yet drug release is facilitated in acidic or basic conditions. NFs deliver Dox into target chemosensitive and MDR cancer cells, preventing drug efflux and enhancing drug retention in MDR cells. Consequently, NF-Dox induces potent cytotoxicity in both target chemosensitive cells and MDR cells, but not nontarget cells, thus concurrently circumventing MDR and reducing side effects. Overall, these NFs are promising to circumvent MDR in targeted cancer therapy.

In situ assembly states of (Na+,K+)-pump ATPase in human erythrocytes. Radiation target size analyses

International Nuclear Information System (INIS)

Hah, J.; Goldinger, J.M.; Jung, C.Y.

1985-01-01

The in situ assembly state of the (Na+,K+)-pump ATPase of human erythrocytes was studied by applying the classical target theory to radiation inactivation data of the ouabain-sensitive sodium efflux and ATP hydrolysis. Erythrocytes and their extensively washed white ghosts were irradiated at -45 to -50 degrees C with an increasing dose of 1.5-MeV electron beam, and after thawing, the Na+-pump flux and/or enzyme activities were assayed. Each activity measured was reduced as a simple exponential function of radiation dose, from which a radiation sensitive mass (target size) was calculated. When intact cells were used, the target sizes for the pump and for the ATPase activities were equal and approximately 620,000 daltons. The target size for the ATPase activity was reduced to approximately 320,000 daltons if the cells were pretreated with digitoxigenin. When ghosts were used, the target size for the ATPase activity was again approximately 320,000 daltons. Our target size measurements together with other information available in literature suggest that (Na+,K+)-pump ATPase may exist in human erythrocytes either as a tetramer of alpha beta or as a dimer of alpha beta in tight association with other protein mass, probably certain glycolytic enzymes, and that this tetrameric or heterocomplex association is dissociable by digitoxigenin treatment or by extensive wash during ghost preparation

Extrapolation of the Dutch 1 MW tunable free electron maser to a 5 MW ECRH source

International Nuclear Information System (INIS)

Caplan, M.; Nelson, S.; Kamin, G.; Antonsen, T. Levush, B.; Urbanus, W.; Tulupov, A.

1995-01-01

A Free Electron Maser (FEM) is now under construction at the FOM Institute (Rijnhuizen) Netherlands with the goal of producing 1 MW long pulse to CW microwave output in the range 130 GHz to 250 GHz with wall plug efficiencies of 50% (Verhoeven, et al EC-9 Conference). An extrapolated version of this device is proposed which by scaling up the beam current, would produce microwave power levels of up to 5 MW CW in order to reduce the cost per watt and increase the power per module, thus providing the fusion community with a practical ECRH source

Disulfide-induced self-assembled targets : A novel strategy for the label free colorimetric detection of DNAs/RNAs via unmodified gold nanoparticles

NARCIS (Netherlands)

Shokri, Ehsan; Hosseini, Morteza; Davari, Mehdi D.; Ganjali, Mohammad R.; Peppelenbosch, Maikel P.; Rezaee, Farhad

2017-01-01

A modified non-cross-linking gold-nanoparticles (Au-NPs) aggregation strategy has been developed for the label free colorimetric detection of DNAs/RNAs based on self-assembling target species in the presence of thiolated probes. Two complementary thiol-modified probes, each of which specifically

Disulfide-induced self-assembled targets: A novel strategy for the label free colorimetric detection of DNAs/RNAs via unmodified gold nanoparticles

NARCIS (Netherlands)

Shokri, E. (Ehsan); M. Hosseini (Morteza); Davari, M.D. (Mehdi D.); Ganjali, M.R. (Mohammad R.); M.P. Peppelenbosch (Maikel); F. Rezaee (Farhad)

2017-01-01

textabstractA modified non-cross-linking gold-nanoparticles (Au-NPs) aggregation strategy has been developed for the label free colorimetric detection of DNAs/RNAs based on self-assembling target species in the presence of thiolated probes. Two complementary thiol- modified probes, each of which

Effects of multi-stakeholder platforms on multi-stakeholder innovation networks: Implications for research for development interventions targeting innovations at scale

Science.gov (United States)

Schut, Marc; Hermans, Frans; van Asten, Piet; Leeuwis, Cees

2018-01-01

Multi-stakeholder platforms (MSPs) have been playing an increasing role in interventions aiming to generate and scale innovations in agricultural systems. However, the contribution of MSPs in achieving innovations and scaling has been varied, and many factors have been reported to be important for their performance. This paper aims to provide evidence on the contribution of MSPs to innovation and scaling by focusing on three developing country cases in Burundi, Democratic Republic of Congo, and Rwanda. Through social network analysis and logistic models, the paper studies the changes in the characteristics of multi-stakeholder innovation networks targeted by MSPs and identifies factors that play significant roles in triggering these changes. The results demonstrate that MSPs do not necessarily expand and decentralize innovation networks but can lead to contraction and centralization in the initial years of implementation. They show that some of the intended next users of interventions with MSPs–local-level actors–left the innovation networks, whereas the lead organization controlling resource allocation in the MSPs substantially increased its centrality. They also indicate that not all the factors of change in innovation networks are country specific. Initial conditions of innovation networks and funding provided by the MSPs are common factors explaining changes in innovation networks across countries and across different network functions. The study argues that investigating multi-stakeholder innovation network characteristics targeted by the MSP using a network approach in early implementation can contribute to better performance in generating and scaling innovations, and that funding can be an effective implementation tool in developing country contexts. PMID:29870559

Effects of multi-stakeholder platforms on multi-stakeholder innovation networks: Implications for research for development interventions targeting innovations at scale.

Science.gov (United States)

Sartas, Murat; Schut, Marc; Hermans, Frans; Asten, Piet van; Leeuwis, Cees

2018-01-01

Multi-stakeholder platforms (MSPs) have been playing an increasing role in interventions aiming to generate and scale innovations in agricultural systems. However, the contribution of MSPs in achieving innovations and scaling has been varied, and many factors have been reported to be important for their performance. This paper aims to provide evidence on the contribution of MSPs to innovation and scaling by focusing on three developing country cases in Burundi, Democratic Republic of Congo, and Rwanda. Through social network analysis and logistic models, the paper studies the changes in the characteristics of multi-stakeholder innovation networks targeted by MSPs and identifies factors that play significant roles in triggering these changes. The results demonstrate that MSPs do not necessarily expand and decentralize innovation networks but can lead to contraction and centralization in the initial years of implementation. They show that some of the intended next users of interventions with MSPs-local-level actors-left the innovation networks, whereas the lead organization controlling resource allocation in the MSPs substantially increased its centrality. They also indicate that not all the factors of change in innovation networks are country specific. Initial conditions of innovation networks and funding provided by the MSPs are common factors explaining changes in innovation networks across countries and across different network functions. The study argues that investigating multi-stakeholder innovation network characteristics targeted by the MSP using a network approach in early implementation can contribute to better performance in generating and scaling innovations, and that funding can be an effective implementation tool in developing country contexts.

Light Rotor: The 10-MW reference wind turbine

DEFF Research Database (Denmark)

Bak, Christian; Bitsche, Robert; Yde, Anders

2012-01-01

design show a rather well performing wind turbine both in terms of power and loads, but in the further work towards the final design the challenges in the control needs to be solved and the balance between power performance and loads and between structural performance and mass will be investigated......This paper describes the design of a rotor and a wind turbine for an artificial 10-MW wind turbine carried out in the Light Rotor project. The turbine called the Light Rotor 10-MW Reference Wind Turbine (LR10-MW RWT), is designed with existing methods and techniques and serves as a reference...... like the determination of the specific power and upscaling of the turbine. The design of Iteration #2 of the LR10-MW RWT is carried out in a sequence between aerodynamic rotor design, structural design and aero-servo-elastic design. Each of these topics is described. The results from the Iteration #2...

Multi-target detection and positioning in crowds using multiple camera surveillance

Science.gov (United States)

Huang, Jiahu; Zhu, Qiuyu; Xing, Yufeng

2018-04-01

In this study, we propose a pixel correspondence algorithm for positioning in crowds based on constraints on the distance between lines of sight, grayscale differences, and height in a world coordinates system. First, a Gaussian mixture model is used to obtain the background and foreground from multi-camera videos. Second, the hair and skin regions are extracted as regions of interest. Finally, the correspondences between each pixel in the region of interest are found under multiple constraints and the targets are positioned by pixel clustering. The algorithm can provide appropriate redundancy information for each target, which decreases the risk of losing targets due to a large viewing angle and wide baseline. To address the correspondence problem for multiple pixels, we construct a pixel-based correspondence model based on a similar permutation matrix, which converts the correspondence problem into a linear programming problem where a similar permutation matrix is found by minimizing an objective function. The correct pixel correspondences can be obtained by determining the optimal solution of this linear programming problem and the three-dimensional position of the targets can also be obtained by pixel clustering. Finally, we verified the algorithm with multiple cameras in experiments, which showed that the algorithm has high accuracy and robustness.

Design of the LBNF Beamline Target Station

Energy Technology Data Exchange (ETDEWEB)

Tariq, S. [Fermilab; Ammigan, K. [Fermilab; Anderson, K.; ; Buccellato, S. A. [Fermilab; Crowley, C. F. [Fermilab; Hartsell, B. D. [Fermilab; Hurh, P. [Fermilab; Hylen, J. [Fermilab; Kasper, P. [Fermilab; Krafczyk, G. E. [Fermilab; Lee, A. [Fermilab; Lundberg, B. [Fermilab; Reitzner, S. D. [Fermilab; Sidorov, V. [Fermilab; Stefanik, A. M. [Fermilab; Tropin, I. S. [Fermilab; Vaziri, K. [Fermilab; Williams, K. [Fermilab; Zwaska, R. M. [Fermilab; Densham, C. [RAL, Didcot

2016-10-01

The Long Baseline Neutrino Facility (LBNF) project will build a beamline located at Fermilab to create and aim an intense neutrino beam of appropriate energy range toward the DUNE detectors at the SURF facility in Lead, South Dakota. Neutrino production starts in the Target Station, which consists of a solid target, magnetic focusing horns, and the associated sub-systems and shielding infrastructure. Protons hit the target producing mesons which are then focused by the horns into a helium-filled decay pipe where they decay into muons and neutrinos. The target and horns are encased in actively cooled steel and concrete shielding in a chamber called the target chase. The reference design chase is filled with air, but nitrogen and helium are being evaluated as alternatives. A replaceable beam window separates the decay pipe from the target chase. The facility is designed for initial operation at 1.2 MW, with the ability to upgrade to 2.4 MW, and is taking advantage of the experience gained by operating Fermilab’s NuMI facility. We discuss here the design status, associated challenges, and ongoing R&D and physics-driven component optimization of the Target Station.

Tests of the RBMK-1500 reactor fuel assemblies in the Leningrad reactor

International Nuclear Information System (INIS)

Aden, V.C.; Varovin, I.A.; Vorontsov, B.A.

1981-01-01

Test of fuel assemblies of the RBMK-1500 reactor is conducted in the reactor of the Leningrad NPP unit 2 for proving the calculational values of critical power of the RBMK-1500 reactor fuel assemblies adopted in design. The experiment presupposes the maximal approximation of the fuel assembly operation parameters to the calculational critical parameters without bringing into the mode of heat transfer crisis. The experiments are carried out at 500, 850 and 900 MW(el) of the reactor. The maximal channel power made up 472 kW at 20.5 t/h coolant flow rate and 49% mass steam content at the outlet of the channel. It was concluded that there was supply up to the heat transfer crisis in all the investigated modes. Data of temperature measurings of the fuel element cans, readings of the devices of the failure control system of the fuel element cans and external inspection of the assemblies after the tests testify to it [ru

Development and testing of a deuterium gas target assembly for neutron production via the H-2(d,n)He-3 reaction at a low-energy accelerator facility

International Nuclear Information System (INIS)

Feautrier, D.; Smith, D.L.

1992-03-01

This report describes the development and testing of a deuterium gas target intended for use at a low-energy accelerator facility to produce neutrons for basic research and various nuclear applications. The principle source reaction is H-2(d,n)He-3. It produces a nearly mono-energetic group of neutrons. However, a lower-energy continuum neutron spectrum is produced by the H-2(d;n,p)H-2 reaction and also by deuterons which strike various components in the target assembly. The present target is designed to achieve the following objectives: (1) minimize unwanted background neutron production from the target assembly, (2) provide a relatively low level of residual long-term activity within the target components, (3) have the capacity to dissipate up to 150 watts of beam power with good target longevity, and (4) possess a relatively modest target mass in order to minimize neutron scattering from the target components. The basic physical principles that have to be considered in designing an accelerator target are discussed and the major engineering features of this particular target design are outlined. The results of initial performance tests on this target are documented and some conclusions concerning the viability of the target design are presented

Exogenous Molecular Probes for Targeted Imaging in Cancer: Focus on Multi-modal Imaging

International Nuclear Information System (INIS)

Joshi, Bishnu P.; Wang, Thomas D.

2010-01-01

Cancer is one of the major causes of mortality and morbidity in our healthcare system. Molecular imaging is an emerging methodology for the early detection of cancer, guidance of therapy, and monitoring of response. The development of new instruments and exogenous molecular probes that can be labeled for multi-modality imaging is critical to this process. Today, molecular imaging is at a crossroad, and new targeted imaging agents are expected to broadly expand our ability to detect and manage cancer. This integrated imaging strategy will permit clinicians to not only localize lesions within the body but also to manage their therapy by visualizing the expression and activity of specific molecules. This information is expected to have a major impact on drug development and understanding of basic cancer biology. At this time, a number of molecular probes have been developed by conjugating various labels to affinity ligands for targeting in different imaging modalities. This review will describe the current status of exogenous molecular probes for optical, scintigraphic, MRI and ultrasound imaging platforms. Furthermore, we will also shed light on how these techniques can be used synergistically in multi-modal platforms and how these techniques are being employed in current research

Multi-technology control centre to integrate 460 MW renewables; Centro de control multitecnología para la integración de 460 MW renovables

Energy Technology Data Exchange (ETDEWEB)

NONE

2016-07-01

The new RWE Innogy Aersa Control Centre that has been certified to act as an interface with CECRE (the Renewable Energy Control Centre) since February 2015, connects RWE’s 20 renewable energy facilities with REE, the Spanish Electricity Grid. As a result, it ensures that wind farms, in addition to hydropower and solar plants, can inject the energy generated by its 460 MW installed safely and with no penalties. Green Eagle Solutions, a provider of software solutions for renewable energy companies, has collaborated with RWE in the development of this Control Centre, meeting the high standards of quality and safety required by RWE. This centre uses CompactSCADA® technology to integrate power generation facilities that need to be integrated in a Control Centre to communicate with REE’s CECRE. (Author)

A Proton Flare Triggered the Mw 8.1 Chiapos Mexican Earthquake

Science.gov (United States)

Elfaki, H.; Yousef, S.

2017-12-01

In a 2015 Cairo University M.Sc. thesis by Sarah Khodairy, very strong earthquakes were found to be highly correlated with proton flares. Strange blue and green bright flashes of light across Mexico accompanied the 8th of September 2017 Mw 1.8 Chiapas earthquake. Those lights were contemporary with a solar proton flare. Those green and blue lights are indicative of the arrival of proton streams over Mexico and their interaction with atmospheric Oxygen and Nitrogen atoms respectively in analogy with aurora lights. The proton streams attacked the weak spots of tectonic plates where the Coscos plate is being subducted below the North American plate. It is suggested that they induced telluric electric currents in the ground and in the magma thus caused motion and more subduction in the tectonic plates. Such motion immediately trigged the Chiapas earthquake in the near vicinity. The Bz component of the interplanetary magnetic field was highly negative, a door was opened in the magnetosphere and the proton stream easily leaked inside and targeted Mexico. This proton flare was accompanied by coronal mass ejection and extremely strong X.9.3- class X-ray flare as well as magnetic storms. On the other hand, the 19th of September Mw 7.1 Puebla central Mexico earthquake was initiated by fast solar wind coronal hole stream. Such stream if they hit ground they cause earthquakes, if they hit narrow seas like the Red Sea they cause flash floods. However if they target Oceans they initiate hurricanes.

Enzyme sensitive smart inulin-dehydropeptide conjugate self-assembles into nanostructures useful for targeted delivery of ornidazole.

Science.gov (United States)

Shivhare, Kriti; Garg, Charu; Priyam, Ayushi; Gupta, Alka; Sharma, Ashwani Kumar; Kumar, Pradeep

2018-01-01

Molecular self-assembly of biodegradable amphiphilic polymers allows rational design of biocompatible nanomaterials for drug delivery. Use of substituted polysaccharides for such applications offers the ease of design and synthesis, and provides higher biofunctionality and biocompatibility to nanomaterials. The present work focuses on the synthesis, characterization and potential biomedical applications of self-assembled polysaccharide-based materials. We demonstrated that the synthesized amphiphilic inulin self-assembled in aqueous medium into nanostructures with average size in the range of 146-486nm and encapsulated hydrophobic therapeutic molecule, ornidazole. Hydrophophic dehydropeptide was conjugated with inulin via a biocompatible ester linkage. Dehydrophenylalanine, an unusual amino acid, was incorporated in the peptide to make it stable at a broader range of pH as well as against proteases. The resulting core-shell type of nanostructures could encapsulate ornidazole in the hydrophobic core and released it in a controlled fashion. By taking the advantage of inulin, which gets degraded in the colon by colonic bacteria, the effect of enzyme, inulinase, present in the microflora of the large intestine, on inulin-peptide degradation followed by drug release has been studied. Altogether, small peptide conjugated to inulin offers novel scaffold for the future design of nanostructures with potential applications in the field of targeted drug delivery. Copyright © 2017 Elsevier B.V. All rights reserved.

Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases.

Science.gov (United States)

Kalash, Leen; Val, Cristina; Azuaje, Jhonny; Loza, María I; Svensson, Fredrik; Zoufir, Azedine; Mervin, Lewis; Ladds, Graham; Brea, José; Glen, Robert; Sotelo, Eddy; Bender, Andreas

2017-12-30

Compounds designed to display polypharmacology may have utility in treating complex diseases, where activity at multiple targets is required to produce a clinical effect. In particular, suitable compounds may be useful in treating neurodegenerative diseases by promoting neuronal survival in a synergistic manner via their multi-target activity at the adenosine A 1 and A 2A receptors (A 1 R and A 2A R) and phosphodiesterase 10A (PDE10A), which modulate intracellular cAMP levels. Hence, in this work we describe a computational method for the design of synthetically feasible ligands that bind to A 1 and A 2A receptors and inhibit phosphodiesterase 10A (PDE10A), involving a retrosynthetic approach employing in silico target prediction and docking, which may be generally applicable to multi-target compound design at several target classes. This approach has identified 2-aminopyridine-3-carbonitriles as the first multi-target ligands at A 1 R, A 2A R and PDE10A, by showing agreement between the ligand and structure based predictions at these targets. The series were synthesized via an efficient one-pot scheme and validated pharmacologically as A 1 R/A 2A R-PDE10A ligands, with IC 50 values of 2.4-10.0 μM at PDE10A and K i values of 34-294 nM at A 1 R and/or A 2A R. Furthermore, selectivity profiling of the synthesized 2-amino-pyridin-3-carbonitriles against other subtypes of both protein families showed that the multi-target ligand 8 exhibited a minimum of twofold selectivity over all tested off-targets. In addition, both compounds 8 and 16 exhibited the desired multi-target profile, which could be considered for further functional efficacy assessment, analog modification for the improvement of selectivity towards A 1 R, A 2A R and PDE10A collectively, and evaluation of their potential synergy in modulating cAMP levels.

Polymer Directed Protein Assemblies

Directory of Open Access Journals (Sweden)

Patrick van Rijn

2013-05-01

Full Text Available Protein aggregation and protein self-assembly is an important occurrence in natural systems, and is in some form or other dictated by biopolymers. Very obvious influences of biopolymers on protein assemblies are, e.g., virus particles. Viruses are a multi-protein assembly of which the morphology is dictated by poly-nucleotides namely RNA or DNA. This “biopolymer” directs the proteins and imposes limitations on the structure like the length or diameter of the particle. Not only do these bionanoparticles use polymer-directed self-assembly, also processes like amyloid formation are in a way a result of directed protein assembly by partial unfolded/misfolded biopolymers namely, polypeptides. The combination of proteins and synthetic polymers, inspired by the natural processes, are therefore regarded as a highly promising area of research. Directed protein assembly is versatile with respect to the possible interactions which brings together the protein and polymer, e.g., electrostatic, v.d. Waals forces or covalent conjugation, and possible combinations are numerous due to the large amounts of different polymers and proteins available. The protein-polymer interacting behavior and overall morphology is envisioned to aid in clarifying protein-protein interactions and are thought to entail some interesting new functions and properties which will ultimately lead to novel bio-hybrid materials.

Autonomous intelligent assembly systems LDRD 105746 final report.

Energy Technology Data Exchange (ETDEWEB)

Anderson, Robert J.

2013-04-01

This report documents a three-year to develop technology that enables mobile robots to perform autonomous assembly tasks in unstructured outdoor environments. This is a multi-tier problem that requires an integration of a large number of different software technologies including: command and control, estimation and localization, distributed communications, object recognition, pose estimation, real-time scanning, and scene interpretation. Although ultimately unsuccessful in achieving a target brick stacking task autonomously, numerous important component technologies were nevertheless developed. Such technologies include: a patent-pending polygon snake algorithm for robust feature tracking, a color grid algorithm for uniquely identification and calibration, a command and control framework for abstracting robot commands, a scanning capability that utilizes a compact robot portable scanner, and more. This report describes this project and these developed technologies.

Development of 70 MW class superconducting generator with quick-response excitation

Science.gov (United States)

Miyaike, Kiyoshi; Kitajima, Toshio; Ito, Tetsuo

2002-03-01

The development of a superconducting generator had been carried out for 12 years under the first stage of a Super GM project. The 70 MW class model machine with quick response excitation was manufactured and evaluated in the project. This type of superconducting generator improves power system stability against rapid load fluctuations at the power system faults. This model machine achieved all development targets including high stability during rapid excitation control. It was also connected to the actual 77 kV electrical power grid as a synchronous condenser and proved advantages and high-operation reliability of the superconducting generator.

Calculation of drop course of control rod assembly in PWR

International Nuclear Information System (INIS)

Zhou Xiaojia; Mao Fei; Min Peng; Lin Shaoxuan

2013-01-01

The validation of control rod drop performance is an important part of safety analysis of nuclear power plant. Development of computer code for calculating control rod drop course will be useful for validating and improving the design of control rod drive line. Based on structural features of the drive line, the driving force on moving assembly was analyzed and decomposed, the transient value of each component of the driving force was calculated by choosing either theoretical method or numerical method, and the simulation code for calculating rod cluster control assembly (RCCA) drop course by time step increase was achieved. The analysis results of control rod assembly drop course calculated by theoretical model and numerical method were validated by comparing with RCCA drop test data of Qinshan Phase Ⅱ 600 MW PWR. It is shown that the developed RCCA drop course calculation code is suitable for RCCA in PWR and can correctly simulate the drop course and the stress of RCCA. (authors)

Global calibration of multi-cameras with non-overlapping fields of view based on photogrammetry and reconfigurable target

Science.gov (United States)

Xia, Renbo; Hu, Maobang; Zhao, Jibin; Chen, Songlin; Chen, Yueling

2018-06-01

Multi-camera vision systems are often needed to achieve large-scale and high-precision measurement because these systems have larger fields of view (FOV) than a single camera. Multiple cameras may have no or narrow overlapping FOVs in many applications, which pose a huge challenge to global calibration. This paper presents a global calibration method for multi-cameras without overlapping FOVs based on photogrammetry technology and a reconfigurable target. Firstly, two planar targets are fixed together and made into a long target according to the distance between the two cameras to be calibrated. The relative positions of the two planar targets can be obtained by photogrammetric methods and used as invariant constraints in global calibration. Then, the reprojection errors of target feature points in the two cameras’ coordinate systems are calculated at the same time and optimized by the Levenberg–Marquardt algorithm to find the optimal solution of the transformation matrix between the two cameras. Finally, all the camera coordinate systems are converted to the reference coordinate system in order to achieve global calibration. Experiments show that the proposed method has the advantages of high accuracy (the RMS error is 0.04 mm) and low cost and is especially suitable for on-site calibration.

Thermal-hydraulic performance of a water-cooled tungsten-rod target for a spallation neutron source

International Nuclear Information System (INIS)

Poston, D.I.

1997-08-01

A thermal-hydraulic (T-H) analysis is conducted to determine the feasibility and limitations of a water-cooled tungsten-rod target at powers of 1 MW and above. The target evaluated has a 10-cm x 10-cm cross section perpendicular to the beam axis, which is typical of an experimental spallation neutron source - both for a short-pulse spallation source and long-pulse spallation source. This report describes the T-H model and assumptions that are used to evaluate the target. A 1-MW baseline target is examined, and the results indicate that this target should easily handle the T-H requirements. The possibility of operating at powers >1 MW is also examined. The T-H design is limited by the condition that the coolant does not boil (actual limits are on surface subcooling and wall heat flux); material temperature limits are not approached. Three possible methods of enhancing the target power capability are presented: reducing peak power density, altering pin dimensions, and improving coolant conditions (pressure and temperature). Based on simple calculations, it appears that this target concept should have little trouble reaching the 2-MW range (from a purely T-H standpoint), and possibly much higher powers. However, one must keep in mind that these conclusions are based solely on thermal-hydraulics. It is possible, and perhaps likely, that target performance could be limited by structural issues at higher powers, particularly for a short-pulse spallation source because of thermal shock issues

A Student’s t Mixture Probability Hypothesis Density Filter for Multi-Target Tracking with Outliers

Science.gov (United States)

Liu, Zhuowei; Chen, Shuxin; Wu, Hao; He, Renke; Hao, Lin

2018-01-01

In multi-target tracking, the outliers-corrupted process and measurement noises can reduce the performance of the probability hypothesis density (PHD) filter severely. To solve the problem, this paper proposed a novel PHD filter, called Student’s t mixture PHD (STM-PHD) filter. The proposed filter models the heavy-tailed process noise and measurement noise as a Student’s t distribution as well as approximates the multi-target intensity as a mixture of Student’s t components to be propagated in time. Then, a closed PHD recursion is obtained based on Student’s t approximation. Our approach can make full use of the heavy-tailed characteristic of a Student’s t distribution to handle the situations with heavy-tailed process and the measurement noises. The simulation results verify that the proposed filter can overcome the negative effect generated by outliers and maintain a good tracking accuracy in the simultaneous presence of process and measurement outliers. PMID:29617348

Hurricane Satellite (HURSAT) Microwave (MW)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Hurricane Satellite (HURSAT) from Microwave (MW) observations of tropical cyclones worldwide data consist of raw satellite observations. The data derive from the...

A high-power target experiment

CERN Document Server

Kirk, H G; Ludewig, H; Palmer, Robert; Samulyak, V; Simos, N; Tsang, Thomas; Bradshaw, T W; Drumm, Paul V; Edgecock, T R; Ivanyushenkov, Yury; Bennett, Roger; Efthymiopoulos, Ilias; Fabich, Adrian; Haseroth, H; Haug, F; Lettry, Jacques; Hayato, Y; Yoshimura, Koji; Gabriel, Tony A; Graves, Van; Spampinato, P; Haines, John; McDonald, Kirk T

2005-01-01

We describe an experiment designed as a proof-of-principle test for a target system capable of converting a 4 MW proton beam into a high-intensity muon beam suitable for incorporation into either a neutrino factory complex or a muon collider. The target system is based on exposing a free mercury jet to an intense proton beam in the presence of a high strength solenoidal field.

Fixture for aligning motor assembly

Science.gov (United States)

Shervington, Roger M.; Vaghani, Vallabh V.; Vanek, Laurence D.; Christensen, Scott A.

2009-12-08

An alignment fixture includes a rotor fixture, a stator fixture and a sensor system which measures a rotational displacement therebetween. The fixture precisely measures rotation of a generator stator assembly away from a NULL position referenced by a unique reference spline on the rotor shaft. By providing an adjustable location of the stator assembly within the housing, the magnetic axes within each generator shall be aligned to a predetermined and controlled tolerance between the generator interface mounting pin and the reference spline on the rotor shaft. Once magnetically aligned, each generator is essentially a line replaceable unit which may be readily mounted to any input of a multi-generator gearbox assembly with the assurance that the magnetic alignment will be within a predetermined tolerance.

A new hybrid target concept for multi-keV X-ray sources

International Nuclear Information System (INIS)

Primout, M.; Babonneau, D.; Jacquet, L.; Villette, B.; Girard, F.; Brebion, D.; Stemmler, P.; Fournier, K.B.; Marrs, R.; May, M.J.; Heeter, R.F.; Wallace, R.J.; Nishimura, H.; Fujioka, S.; Tanabe, M.; Nagai, H.

2013-01-01

A novel concept for using hybrid targets to create multi-keV X-ray sources was tested on the GEKKO XII facility of the Osaka University and on the OMEGA facility of the University of Rochester. The sources were made via laser irradiation of a titanium foil placed at the end of a plastic cylinder, filled with a very low-density (2 and 5 mg/cm 3 ) silicon-dioxide aerogel that was designed to control the longitudinal expansion of the titanium plasma. Preliminary calculations were used to determine optimal conditions for the aerogel density, cylinder diameter and length that maximize multi-keV X-ray emission. The X-ray emission power was measured on OMEGA using absolutely calibrated broad-band, diode-based CEA diagnostics, in addition to high resolution crystal spectrometers. On GEKKO XII, the heat wave propagation velocity in the aerogel was also measured with an X-ray framing camera. The advantage of using the thermal wave generated in the aerogel to heat a solid material to increase the conversion efficiency has not been fully demonstrated in these experiments. However, it was shown that a 5 mg/cm 3 aerogel placed in front of a titanium foil can improve the x-ray conversion efficiency with respect to the case of 2 mg/cm 3 for some target diameter and length. (authors)

Self-assembled arene-ruthenium-based rectangles for the selective sensing of multi-carboxylate anions.

Science.gov (United States)

Vajpayee, Vaishali; Song, Young Ho; Lee, Min Hyung; Kim, Hyunuk; Wang, Ming; Stang, Peter J; Chi, Ki-Whan

2011-07-04

Novel arene-ruthenium [2+2] metalla-rectangles 4 and 5 have been synthesized by self-assembly using dipyridyl amide ligand 3 and arene-ruthenium acceptors (arene: benzoquinone (1), naphthacenedione (2)) and characterized by NMR spectroscopy and ESI-MS. The solid-state structure of 5 was determined by X-ray diffraction and shows encapsulated diethyl ether molecule in the rectangular cavity of 5. The luminescent 5 was further used for anion sensing with the amidic linkage serving as a hydrogen-bond donor site for anions and the ruthenium moiety serving as a signaling unit. A UV/Vis titration study demonstrated that although 5 interacts very weakly with common monoanions as well as with flexible dicarboxylate anions such as malonate and succinate, it displays significant binding affinity (K>10(3) in MeOH) for rigid multi-carboxylate anions such as oxalate, citrate, and tartrate, exhibiting a 1:1 stoichiometry. It has been suggested that 1:1 bidentate hydrogen bonding assisted by appropriate geometrical complementarity is mainly responsible for the increased affinity of 5 towards such anions. A fluorescence titration study revealed a large fluorescence enhancement of 5 upon binding to multi-carboxylate anions, which can be attributed to the blocking of the photoinduced electron-transfer process from the arene-Ru moiety to the amidic donor in 5 as a result of hydrogen bonding between the donor and the anion. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The DAN-AERO MW experiments. Final report

Energy Technology Data Exchange (ETDEWEB)

Aagaard Madsen, H.; Bak, C.; Schmidt Paulsen, U.; Gaunaa, M. (Risoe DTU, Roskilde (Denmark)); Fuglsang, P. (LM Glasfiber, Kolding (Denmark)); Romblad, J.; Olesen, N.A. (Vestas Wind Systems, Ringkoebing (Denmark)); Enevoldsen, P.; Laursen, J. (Siemens Wind Power, Ballerup (Denmark)); Jensen, Leo (DONG Energy, Fredericia (Denmark))

2010-09-15

This report describes the DAN-AERO MW experiments carried out within a collaborative, three years research project between Risoe DTU and the industrial partners LM Glasfiber, Siemens Wind Power, Vestas Wind Systems A/S and the utility company DONG Energy. The main objective of the project was to establish an experimental data base which can provide new insight into a number of fundamental aerodynamic and aero-acoustic issues, important for the design and operation of MW size turbines. The most important issue is the difference between airfoil characteristics measured under 2D, steady conditions in a wind tunnel and the unsteady 3D flow conditions on a rotor. The different transition characteristics might explain some of the differences between the 2D and 3D airfoil data and the experiments have been set up to provide data on this subject. The overall experimental approach has been to carry out a number of coordinated, innovative measurements on full scale MW size rotors as well as on airfoils for MW size turbines in wind tunnels. Shear and turbulence inflow characteristics were measured on a Siemens 3.6 MW turbine with a five hole pitot tube. Pressure and turbulent inflow characteristics were measured on a 2MW NM80 turbine with an 80 m rotor. One of the LM38.8 m blades on the rotor was replaced with a new LM38.8 m blade where instruments for surface pressure measurements at four radial sections were build into the blade during the blade production process. Additionally, the outmost section on the blade was further instrumented with around 50 microphones for high frequency surface pressure measurements. The surface pressure measurements have been correlated with inflow measurements from four five hole pitot tubes and two sensors for measuring the high frequency (50 Hz to10 kHz) contents of the inflow turbulence. In parallel, 2D wind tunnel measurements on common airfoils for wind turbine applications have been conducted in three different wind tunnels at Delft

SAR Target Recognition Using the Multi-aspect-aware Bidirectional LSTM Recurrent Neural Networks

OpenAIRE

Zhang, Fan; Hu, Chen; Yin, Qiang; Li, Wei; Li, Hengchao; Hong, Wen

2017-01-01

The outstanding pattern recognition performance of deep learning brings new vitality to the synthetic aperture radar (SAR) automatic target recognition (ATR). However, there is a limitation in current deep learning based ATR solution that each learning process only handle one SAR image, namely learning the static scattering information, while missing the space-varying information. It is obvious that multi-aspect joint recognition introduced space-varying scattering information should improve ...

30 400 MW worldwide in early 2003

International Nuclear Information System (INIS)

Anon.

2003-01-01

Accounting for more than 74% of wind power output in the world, Europe is now more than ever the spearhead of the wind energy industry. First estimates for 2002 show a 6 000 MW progression that now places total world output around 30 400 MW, that is enough to electrify 17 million households. Nevertheless, although it's still growing at a remarkable speed, the rate of development for wind energy has slowed down for the first time in years. (authors)

Antiproton Target

CERN Multimedia

1980-01-01

Antiproton target used for the AA (antiproton accumulator). The first type of antiproton production target used from 1980 to 1982 comprised a rod of copper 3mm diameter and 120mm long embedded in a graphite cylinder that was itself pressed into a finned aluminium container. This assembly was air-cooled and it was used in conjunction with the Van der Meer magnetic horn. In 1983 Fermilab provided us with lithium lenses to replace the horn with a view to increasing the antiproton yield by about 30%. These lenses needed a much shorter target made of heavy metal - iridium was chosen for this purpose. The 50 mm iridium rod was housed in an extension to the original finned target container so that it could be brought very close to the entrance to the lithium lens. Picture 1 shows this target assembly and Picture 2 shows it mounted together with the lithium lens. These target containers had a short lifetime due to a combination of beam heating and radiation damage. This led to the design of the water-cooled target in...

Energy and Exergy Analysis of 210 MW Jamshoro Thermal Power Plant

Directory of Open Access Journals (Sweden)

Muhib Ali Rajper

2016-04-01

Full Text Available In this paper, thermodynamic analysis of 210 MW dual-fire, subcritical, reheat steam power plant, situated near Jamshoro, Pakistan has been performed. Firstly, the plant is modeled by EES (Engineering Equation Solver software. Moreover; a parametric study is performed to assess the impacts of various operating parameters on the performance. The net power output, energy efficiency and exergy efficiency are considered as performance parameters of the plant whereas, condenser pressure, main steam pressure and main steam temperature are nominated as operating parameters. According to the results, the net power output, energy efficiency and exergy efficiency are determined as 186.5 MW, 31.37% and 30.41% respectively, under design operating conditions. The condenser contributed a major share in the total energy loss i.e. 280 MW (68.7% followed by boiler with 89 MW (21.8%. The major exergy destructing area is found in the boiler with 350 MW (82.11% of the total exergy destruction followed by turbine with 43.1 MW (10.12% and condenser 12 MW (5.74 %. According to the parametric study, variation in operating parameters had great influence on the plant performance

Development of a 5 MW reference gearbox for offshore wind turbines: 5 MW reference gearbox

Energy Technology Data Exchange (ETDEWEB)

Nejad, Amir Rasekhi [Norwegian Research Center for Offshore Wind Technology, Norwegian University of Science and Technology, Trondheim Norway; Center for Ships and Ocean Structures, Norwegian University of Science and Technology, Trondheim Norway; Guo, Yi [National Wind Technology Center, National Renewable Energy Laboratory, Golden Colorado USA; Gao, Zhen [Center for Ships and Ocean Structures, Norwegian University of Science and Technology, Trondheim Norway; Moan, Torgeir [Norwegian Research Center for Offshore Wind Technology, Norwegian University of Science and Technology, Trondheim Norway; Center for Ships and Ocean Structures, Norwegian University of Science and Technology, Trondheim Norway

2015-07-27

This paper presents detailed descriptions, modeling parameters and technical data of a 5MW high-speed gearbox developed for the National Renewable Energy Laboratory offshore 5MW baseline wind turbine. The main aim of this paper is to support the concept studies and research for large offshore wind turbines by providing a baseline gearbox model with detailed modeling parameters. This baseline gearbox follows the most conventional design types of those used in wind turbines. It is based on the four-point supports: two main bearings and two torque arms. The gearbox consists of three stages: two planetary and one parallel stage gears. The gear ratios among the stages are calculated in a way to obtain the minimum gearbox weight. The gearbox components are designed and selected based on the offshore wind turbine design codes and validated by comparison to the data available from large offshore wind turbine prototypes. All parameters required to establish the dynamic model of the gearbox are then provided. Moreover, a maintenance map indicating components with high to low probability of failure is shown. The 5 MW reference gearbox can be used as a baseline for research on wind turbine gearboxes and comparison studies. It can also be employed in global analysis tools to represent a more realistic model of a gearbox in a coupled analysis.

Multi-target directed donepezil-like ligands for Alzheimer's disease

Directory of Open Access Journals (Sweden)

Mercedes eUnzeta

2016-05-01

Full Text Available Alzheimer's disease (AD, the most common form of adult onset dementia, is an age-related neurodegenerative disorder characterized by progressive memory loss, decline in language skills and other cognitive impairments. Although its etiology is not completely known, several factors including deficits of acetylcholine, β-amyloid deposits, τ-protein phosphorylation, oxidative stress and neuroinflammation are considered to play significant roles in the pathophysiology of this disease. For a long time, AD patients have been treated with acetylcholinesterase inhibitors such as donepezil (Aricept® but with limited therapeutic success. This might be due to the complex multifactorial nature of AD, a fact that has prompted the design of new Multi-Target-Directed Ligands (MTDL based on the one molecule, multiple targets paradigm. Thus, in this context, different series of novel multifunctional molecules with antioxidant, anti-amyloid, anti-inflammatory and metal-chelating properties able to interact with multiple enzymes of therapeutic interest in AD pathology including acetylcholinesterase, butyrylcholinesterase and monoamine oxidases A and B have been designed and assessed biologically. This review describes the multiple targets, the design rationale and an in-house MTDL library, bearing the N-benzylpiperidine motif present in donepezil, linked to different heterocyclic ring systems (indole, pyridine or 8-hydroxyquinoline with special emphasis on compound ASS234, an N-propargylindole derivative. The description of the in vitro biological properties of the compounds and discussion of the corresponding structure-activity-relationships allows us to highlight new issues for the identification of more efficient MTDL for use in AD therapy.

Recognition of a 30,000 MW antigen of Giardia muris trophozoites by intestinal IgA from Giardia-infected mice.

Science.gov (United States)

Heyworth, M F; Pappo, J

1990-08-01

The principal aims of this work were (i) to identify the molecular weight (MW) of Giardia muris trophozoite antigens that are recognized by IgA in small intestinal secretions from G. muris-infected mice, and (ii) to determine whether mouse intestinal Giardia-specific IgA is directed against trophozoite surfaces. BALB/c mice were infected with G. muris cysts, and intestinal secretions were harvested from these mice at various times after the start of Giardia infection, and from uninfected mice. Flow cytometry showed that intestinal IgA from G. muris-infected mice, but not from uninfected mice, became bound to trophozoite surfaces in vitro. Western blotting of trophozoite proteins with mouse intestinal secretions showed that IgA from Giardia-infected mice reacted specifically with a broad protein band of approximately 30,000 MW. This finding suggests that one or more trophozoite proteins of approximately 30,000 MW are targets for intestinal antibody in mice infected with G. muris.

Eurisol-DS Multi MW Target Preliminary Study of the Windlowless Transverse Film (WTF) Liquid Metal Proton-to Neutron Converter

CERN Document Server

Kadi, Y; Rocca, R; Samec, K

2008-01-01

This technical note summarises the design calculations performed within Task#2 of the European Isotope Separation On-Line Radioactive Ion Beam Facility Design Study (EURISOL-DS) for the WTF (Windowless Transverse Film) mercur converter. A preliminary study was carried out in order to determine the heat deposition within the mercury and estimate the mercury velocity needed in the film. The geometry used is based on previous analysis simulated using the Monte Carlo code FLUKA. The results of these calculations show the baseline parameters, which will be used for the detailed design. Particularly, with a 1 GeV proton beam with a $\\sigma$ ~2 mm Gaussian distribution on a 4x30x40cm long target and with a 5m/s velocity at the peak power density region seems a suitable solution.

2 MW 110 GHz ECH heating system for DIII-D

International Nuclear Information System (INIS)

Moeller, C.; Prater, R.; Callis, R.; Remsen, D.; Doane, J.; Cary, W.; Phelps, R.; Tupper, M.

1990-09-01

A 2 MW 110 GHz ECH system using Varian 0.5 MW gyrotrons is under construction for use on the DIII-D tokamak by late 1991. Most of the components are being design and fabricated at General Atomics, including the gyrotron tanks, superconducting magnets, and transmission line. These components are intended for operation with 10 second pulses and, in the future, with 1 MW gyrotrons. 6 refs., 5 figs

Magnetic Multi-Scale Mapping to Characterize Anthropogenic Targets

Science.gov (United States)

Le Maire, P.; Munschy, M.

2017-12-01

The discovery of buried anthropic objects on construction sites can cause delays and/or dangers for workers and for the public. Indeed, every year 500 tons of Unexploded-ordnance are discovered in France. Magnetic measurements are useful to localize magnetized objects. Moreover, it is the cheapest geophysical method which does not impact environment and which is relatively fast to perform. Fluxgate magnetometers (three components) are used to measure magnetic properties bellow the ground. These magnetic sensors are not absolute, so they need to be calibrated before the onset of the measurements. The advantage is that they allow magnetic compensation of the equipment attached to the sensor. So the choice of this kind sensor gives the opportunity to install the equipment aboard different magnetized supports: boat, quad bike, unmanned aerial vehicle, aircraft,... Indeed, this methodology permits to perform magnetic mapping with different scale and different elevation above ground level. An old French aerial military plant was chosen to perform this multi-scale approach. The advantage of the site is that it contains a lot of different targets with variable sizes and depth, e.g. buildings, unexploded-ordnances of the two world wars, trenches, pipes,… By comparison between the different magnetic anomaly maps at different elevations some of the geometric parameters of the magnetic sources can be characterized. The comparison between measured maps at different elevations and the prolonged map highlights the maximum distance for the target's detection (figure).

Folate mediated self-assembled phytosterol-alginate nanoparticles for targeted intracellular anticancer drug delivery.

Science.gov (United States)

Wang, Jianting; Wang, Ming; Zheng, Mingming; Guo, Qiong; Wang, Yafan; Wang, Heqing; Xie, Xiangrong; Huang, Fenghong; Gong, Renmin

2015-05-01

Self-assembled core/shell nanoparticles (NPs) were synthesized from water-soluble alginate substituted by hydrophobic phytosterols. Folate, a cancer-cell-specific ligand, was conjugated to the phytosterol-alginate (PA) NPs for targeting folate-receptor-overexpressing cancer cells. The physicochemical properties of folate-phytosterol-alginate (FPA) NPs were characterized by nuclear magnetic resonance, transmission electron microscopy, dynamic light scattering, electrophoretic light scattering, and fluorescence spectroscopy. Doxorubicin (DOX), an anticancer drug, was entrapped inside prepared NPs by dialysis method. The identification of prepared FPA NPs to folate-receptor-overexpressing cancer cells (KB cells) was confirmed by cytotoxicity and folate competition assays. Compared to the pure DOX and DOX/PA NPs, the DOX/FPA NPs had lower IC50 value to KB cells because of folate-receptor-mediated endocytosis process and the cytotoxicity of DOX/FPA NPs to KB cells could be competitively inhibited by free folate. The cellular uptake and internalization of pure DOX and DOX/FPA NPs was confirmed by confocal laser scanning microscopy image and the higher intracellular uptake of drug for DOX/FPA NPs over pure DOX was observed. The FPA NPs had the potential as a promising carrier to target drugs to cancer cells overexpressing folate receptors and avoid cytotoxicity to normal tissues. Copyright © 2015 Elsevier B.V. All rights reserved.

Fuel assembly design for APR1400 with low CBC

Energy Technology Data Exchange (ETDEWEB)

Hah, Chang Joo, E-mail: changhah@kings.ac.kr [Department of NPP Engineering, KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

2015-04-29

APR 1400 is a PWR (Pressurized Water Reactor) with rated power of 3983 MWth and 241 assemblies. Recently, demand for extremely longer cycle up to 24 months is increasing with challenge of higher critical boron concentration (CBC). In this paper, assembly design method of selecting Gd-rods is introduced to reduce CBC. The purpose of the method is to lower the critical boron concentration of the preliminary core loading pattern (PLP), and consequently to achieve more negative or less positive moderator temperature coefficient (MTC). In this method, both the ratio of the number of low-Gd rod to the number of high-Gd rod (r) and assembly average Gd wt% (w) are the decision variables. The target function is the amount of soluble boron concentration reduction, which can be converted to Δk{sub TARGET}. A set of new designed fuel assembly satisfies an objective function, min [f=∑{sub i}(Δk{sub FA}−Δk{sub i})], and enables a final loading pattern to reach a target CBC. The constraints required to determine a set of Δk are physically realizable pair, (r,w), and the sum of Δk of new designed assemblies as close to Δk{sub TARGET} as possible. New Gd-bearing assemblies selected based on valid pairs of (r,w) are replaced with existing assemblies in a PLP. This design methodology is applied to Shin-Kori Unit 3 Cycle 1 used as a reference model. CASMO-3/MASTER code is used for depletion calculation. CASMO-3/MASTER calculations with new designed assemblies produce lower CBC than the expected CBC, proving that the proposed method works successful.

2μm all fiber multi-wavelength Tm/Ho co-doped fiber laser

Science.gov (United States)

Zhang, Junhong; Jiang, Qiuxia; Wang, Xiaofa

2017-10-01

A 2 μm all fiber multi-wavelength Tm/Ho co-doped fiber laser based on a simple ring cavity is experimentally demonstrated. Compared with other 2 μm multi-wavelength Tm/Ho co-doped fiber lasers, the multi-wavelength fiber laser is obtained by the gain saturation effect and inhomogeneous broadening effect without any frequency selector component, filter component or polarization-dependent component. When the pump power is about 304 mW, the fiber laser enters into single-wavelength working state around 1967.76 nm. Further increasing the pump power to 455 mW, a stable dual-wavelength laser is obtained at room temperature. The bimodal power difference between λ1 and λ2 is 5.528 dB. The fluctuations of wavelength and power are less than 0.03 nm and 0.264 dB in an hour, which demonstrates that the multi-wavelength fiber laser works at a stable state. Furthermore, a research about the relationship between the pump power and the output spectra has been made.

Tablet—next generation sequence assembly visualization

Science.gov (United States)

Milne, Iain; Bayer, Micha; Cardle, Linda; Shaw, Paul; Stephen, Gordon; Wright, Frank; Marshall, David

2010-01-01

Summary: Tablet is a lightweight, high-performance graphical viewer for next-generation sequence assemblies and alignments. Supporting a range of input assembly formats, Tablet provides high-quality visualizations showing data in packed or stacked views, allowing instant access and navigation to any region of interest, and whole contig overviews and data summaries. Tablet is both multi-core aware and memory efficient, allowing it to handle assemblies containing millions of reads, even on a 32-bit desktop machine. Availability: Tablet is freely available for Microsoft Windows, Apple Mac OS X, Linux and Solaris. Fully bundled installers can be downloaded from http://bioinf.scri.ac.uk/tablet in 32- and 64-bit versions. Contact: tablet@scri.ac.uk PMID:19965881

FABRICATION AND CHARACTERIZATION OF FAST IGNITION TARGETS

International Nuclear Information System (INIS)

HILL, D.W; CASTILLO, E; CHEN, K.C; GRANT, S.E; GREENWOOD, A.L; KAAE, J.L; NIKROO, A; PAGUIO, S.P; SHEARER, C; SMITH, J.N Jr.; STEPHENS, R.B; STEINMAN, D.A; WALL, J.

2003-09-01

OAK-B135 Fast ignition is a novel scheme for achieving laser fusion. A class of these targets involves cone mounted CH shells. The authors have been fabricating such targets with shells with a wide variety of diameters and wall thicknesses for several years at General Atomics. In addition, recently such shells were needed for implosion experiments at Laboratory for Laser Energetics (LLE) that for the first time were required to be gas retentive. Fabrication of these targets requires producing appropriate cones and shells, assembling the targets, and characterization of the assembled targets. The cones are produced using micromachining and plating techniques. The shells are fabricated using the depolymerizable mandrel technique followed by micromachining a hole for the cone. The cone and the shell then need to be assembled properly for gas retention and precisely in order to position the cone tip at the desired position within the shell. Both are critical for the fast ignition experiments. The presence of the cone in the shell creates new challenges in characterization of the assembled targets. Finally, for targets requiring a gas fill, the cone-shell assembly needs to be tested for gas retention and proper strength at the glue joint. This paper presents an overview of the developmental efforts and technical issues addressed during the fabrication of fast ignition targets

APT target-blanket fabrication development

Energy Technology Data Exchange (ETDEWEB)

Fisher, D.L.

1997-06-13

Concepts for producing tritium in an accelerator were translated into hardware for engineering studies of tritium generation, heat transfer, and effects of proton-neutron flux on materials. Small-scale target- blanket assemblies were fabricated and material samples prepared for these performance tests. Blanket assemblies utilize composite aluminum-lead modules, the two primary materials of the blanket. Several approaches are being investigated to produce large-scale assemblies, developing fabrication and assembly methods for their commercial manufacture. Small-scale target-blanket assemblies, designed and fabricated at the Savannah River Site, were place in Los Alamos Neutron Science Center (LANSCE) for irradiation. They were subjected to neutron flux for nine months during 1996-97. Coincident with this test was the development of production methods for large- scale modules. Increasing module size presented challenges that required new methods to be developed for fabrication and assembly. After development, these methods were demonstrated by fabricating and assembling two production-scale modules.

A highly sensitive label-free electrochemical aptasensor for interferon-gamma detection based on graphene controlled assembly and nuclease cleavage-assisted target recycling amplification.

Science.gov (United States)

Yan, Genping; Wang, Yonghong; He, Xiaoxiao; Wang, Kemin; Liu, Jinquan; Du, Yudan

2013-06-15

We report here a highly sensitive and label-free electrochemical aptasensing technology for detection of interferon-gamma (IFN-γ) based on graphene controlled assembly and enzyme cleavage-assisted target recycling amplification strategy. In this work, in the absence of IFN-γ, the graphene could not be assembled onto the 16-mercaptohexadecanoic acid (MHA) modified gold electrode because the IFN-γ binding aptamer was strongly adsorbed on the graphene due to the strong π-π interaction. Thus the electronic transmission was blocked (eT OFF). However, the presence of target IFN-γ and DNase I led to desorption of aptamer from the graphene surface and further cleavage of the aptamer, thereby releasing the IFN-γ. The released IFN-γ could then re-attack other aptamers on the graphene, resulting in the successive release of the aptamers from the graphene. At the same time, the "naked" graphene could be assembled onto the MHA modified gold electrode with hydrophobic interaction and π-conjunction, mediating the electron transfer between the electrode and the electroactive indicator. Then, measurable electrochemical signals were generated (eT ON), which was related to the concentration of the IFN-γ. By taking advantages of graphene and enzyme cleavage-assisted target recycling amplification, the developed label-free electrochemical aptasensing technology showed a linear response to concentration of IFN-γ range from 0.1 to 0.7 pM. The detection limit of IFN-γ was determined to be 0.065 pM. Moreover, this aptasensor shows good selectivity toward the target in the presence of other relevant proteins. Our strategy thus opens new opportunities for label-free and amplified detection of other kinds of proteins. Copyright © 2013 Elsevier B.V. All rights reserved.

Temperature simulations for the SPIRAL ISOL target

International Nuclear Information System (INIS)

Maunoury, L.; Bajeat, O.; Lichtenthaler, R.; Villari, A.C.C.

2001-01-01

Simulations of the power deposition and target temperature distributions in the SPIRAL ISOL target are presented. These simulations consider different heavy-ion beams with intensities corresponding to 2 and 6 kW on a carbon target. A new solutions, which corresponds to the splitting of the production target into two parts, where the first is cooled and the second is heated, allows keeping the overall size of the target ensemble relatively small. An extrapolation of the considered target geometry to primary beam intensities up to 1 MW is also presented. (authors)

Efficient methods for targeted mutagenesis in zebrafish using zinc-finger nucleases: data from targeting of nine genes using CompoZr or CoDA ZFNs.

Directory of Open Access Journals (Sweden)

Raman Sood

Full Text Available Recently, it has been shown that targeted mutagenesis using zinc-finger nucleases (ZFNs and transcription activator-like effector nucleases (TALENs can be used to generate knockout zebrafish lines for analysis of their function and/or developing disease models. A number of different methods have been developed for the design and assembly of gene-specific ZFNs and TALENs, making them easily available to most zebrafish researchers. Regardless of the choice of targeting nuclease, the process of generating mutant fish is similar. It is a time-consuming and multi-step process that can benefit significantly from development of efficient high throughput methods. In this study, we used ZFNs assembled through either the CompoZr (Sigma-Aldrich or the CoDA (context-dependent assembly platforms to generate mutant zebrafish for nine genes. We report our improved high throughput methods for 1 evaluation of ZFNs activity by somatic lesion analysis using colony PCR, eliminating the need for plasmid DNA extractions from a large number of clones, and 2 a sensitive founder screening strategy using fluorescent PCR with PIG-tailed primers that eliminates the stutter bands and accurately identifies even single nucleotide insertions and deletions. Using these protocols, we have generated multiple mutant alleles for seven genes, five of which were targeted with CompoZr ZFNs and two with CoDA ZFNs. Our data also revealed that at least five-fold higher mRNA dose was required to achieve mutagenesis with CoDA ZFNs than with CompoZr ZFNs, and their somatic lesion frequency was lower (<5% when compared to CopmoZr ZFNs (9-98%. This work provides high throughput protocols for efficient generation of zebrafish mutants using ZFNs and TALENs.

Layer-by-layer assemblies of chitosan/multi-wall carbon nanotubes and glucose oxidase for amperometric glucose biosensor applications

International Nuclear Information System (INIS)

Wu Baoyan; Hou Shihua; Yu Min; Qin Xia; Li, Sha; Chen Qiang

2009-01-01

A novel amperometric glucose biosensor based on multilayer films containing chitosan, multi-wall carbon nanotubes (MWCNTs) and glucose oxidase (GOD) was developed. MWCNTs were solubilized in chitosan (Chit-MWCNTs) used to interact with GOD. Poly (allylamine) (PAA) and polyvinylsulfuric acid potassium salt (PVS) were alternately deposited on the cleaned Pt electrode surface ((PVS/PAA) 3 /Pt). The (PVS/PAA) 3 /Pt electrode was alternately immersed in Chit-MWCNTs and GOD to assemble different layers of multilayer films. PBS washing was applied at the end of each assembly deposition for dissociating the weak adsorption. Micrographs of MWCNTs were obtained by scanning electron microscope, and properties of the resulting biosensors were measured by electrochemical measurements. Among the resulting biosensors, the biosensor based on eight layers of multilayer films was best. The resulting biosensor was able to efficiently monitor glucose, with the response time within 8 s, a detection limit of 21 μM estimated at a signal-to-noise ratio of 3, a linear range of 1-10 mM, the sensitivity of 0.45 μA/mM, and well stability. The study can provide a feasible simple approach on developing a new immobilization matrix for biosensors and surface functionalization

Progress of the 10 MW ECRH System for W7-X

International Nuclear Information System (INIS)

Michel, G.; Brand, P.; Dammertz, G.

2003-01-01

The electron cyclotron resonance heating system for the W7-X stellarator is a joint effort of the Max-Planck-Institut fuer Plasmaphysik in Greifswald, the Institut fuer Plasmaforschung Stuttgart and the Forschungszentrum Karlsruhe under the supervision of the latter. Currently it is being constructed at the Greifswald branch of IPP. It will consist of 10 gyrotrons (each with 1 MW 140 GHz in the CW regime) and a quasi optical multi-beam transmission line. W7-X gyrotron candidates are being developed separately in Western Europe and the USA. The prototype phase of the gyrotrons is almost over and significant results have been achieved. The manufacturing of the transmission line is ongoing. An overview over the system including data acquisition and control issues will be given and the current status of the construction will be presented. (authors)

The first test results of the new MAN 6 MW gas turbine; Erste Erprobungsergebnisse zur neuen 6-MW-MAN-Gasturbine

Energy Technology Data Exchange (ETDEWEB)

Beukenberg, Markus; Wiedermann, Alexander; Orth, Ulrich; Aschenbruck, Emil; Reiss, Frank [MAN Diesel und Turbo SE, Oberhausen (Germany)

2011-07-01

The development of a completely new series of gas turbines requires significant capital, resources and know-how. MAN Diesel and Turbo strategically decided to create a gas turbine in the 6 MW class. The construction of the gas turbine has been on the basis of opportunities in current and future markets and the positioning of competition, this has determined the characteristics and technical parameters which have been optimised in the 6 MW design. (orig.)

Identification of Factors Promoting HBV Capsid Self-Assembly by Assembly-Promoting Antivirals.

Science.gov (United States)

Rath, Soumya Lipsa; Liu, Huihui; Okazaki, Susumu; Shinoda, Wataru

2018-02-26

Around 270 million individuals currently live with hepatitis B virus (HBV) infection. Heteroaryldihydropyrimidines (HAPs) are a family of antivirals that target the HBV capsid protein and induce aberrant self-assembly. The capsids formed resemble the native capsid structure but are unable to propagate the virus progeny because of a lack of RNA/DNA. Under normal conditions, self-assembly is initiated by the viral genome. The mode of action of HAPs, however, remains largely unknown. In this work, using molecular dynamics simulations, we attempted to understand the action of HAP by comparing the dynamics of capsid proteins with and without HAPs. We found that the inhibitor is more stable in higher oligomers. It retains its stability in the hexamer throughout 1 μs of simulation. Our results also show that the inhibitor might help in stabilizing the C-terminus, the HBc 149-183 arginine-rich domain of the capsid protein. The C-termini of dimers interact with each other, assisted by the HAP inhibitor. During capsid assembly, the termini are supposed to directly interact with the viral genome, thereby suggesting that the viral genome might work in a similar way to stabilize the capsid protein. Our results may help in understanding the underlying molecular mechanism of HBV capsid self-assembly, which should be crucial for exploring new drug targets and structure-based drug design.

Flap controllers applied on the OffshoreWindChina (OWC) 5MW reference wind turbine for Chinese typhoon conditions

DEFF Research Database (Denmark)

Barlas, Athanasios

The report describes the development of flap controllers applied on the OffshoreWindChina (OWC) 5MW reference wind turbine for Chinese typhoon conditions. Optimal flap controllers are designed and tuned based on linear aeroelastic models from HawcStab2. The controllers are evaluated in normal......, parked and storm conditions, targeting the alleviation of fatigue and extreme loads....

Research on Outfitting Virtual Assembly based on Ergonomics

Directory of Open Access Journals (Sweden)

Jiang Zuhua

2018-01-01

Full Text Available To improve the present situation where the assembly work of ship outfitting depends on manual experiential operation, the thesis, taking outfitting assembly operation as the research object and optimal assembly path as the target, puts forward the simulation method and procedure of outfitting virtual assembly considering operational posture, operational load, reachability and visibility and other ergonomic factors, taking pipe assembly operation of ship section as the application example. The results show that the method can obtain better assembly operation path, avoid interference of workers’ operation process and improve the efficiency of assembly operation.

Thimble vibration analysis and monitoring on 1300 and 900 MW reactors using accelerometers and in core neutron noise

International Nuclear Information System (INIS)

Trenty, A.; Puyal, C.; Vincent, C.; Baeyens, R.; Messainguiral-Bruynooghe, C.; Lagarde, G.

1988-01-01

The axial flow along the thimbles of the in core instrumentation induces vibration and shocks against their guides in the vessel, producing wear and even leakage, either on the thimbles, or on the instrumentation tube of the fuel assemblies. In order to characterize the phenomenon and help to reduce or suppress vibration of the thimbles, two methods have been developed and applied to French and Belgian reactors. The first one consists of an analysis of the shocks perceived on the thimbles tubes by accelerometers; this analysis, based on the study of statistical distribution (amplitude, impulse rate of shocks...) has allowed to choose among the different solutions proposed to solve the problem; this choice has been confirmed by direct wear measurements made later. The second method is based on spectral and time analysis of the fluctuating signals from in core neutron chambers. The correlation appears clearly between shocks and fluctuations. An estimation of the thimble model shape in the instrumentation tube of the assembly, has been made. These two analysis methods have been widely applied during start-up of the first eight 1300 MW reactors: they have contributed to solve the problem and to increase the availability of these plants. On the 900 MW reactors, where the problem is less severe, the approach has been to study the mechanical behaviour of one new plant, Chinon B3: all in core guide tubes have been equipped with accelerometers and an on line monitoring system directly transmits to Chatou the parameters of shocks, in order to define an acoustic parameter able to characterize wear, and so, to define a new type of maintenance for the thimbles. The first results are presented. (author)

Heterogeneous MEMS device assembly and integration

Science.gov (United States)

Topart, Patrice; Picard, Francis; Ilias, Samir; Alain, Christine; Chevalier, Claude; Fisette, Bruno; Paultre, Jacques E.; Généreux, Francis; Legros, Mathieu; Lepage, Jean-François; Laverdière, Christian; Ngo Phong, Linh; Caron, Jean-Sol; Desroches, Yan

2014-03-01

In recent years, smart phone applications have both raised the pressure for cost and time to market reduction, and the need for high performance MEMS devices. This trend has led the MEMS community to develop multi-die packaging of different functionalities or multi-technology (i.e. wafer) approaches to fabricate and assemble devices respectively. This paper reports on the fabrication, assembly and packaging at INO of various MEMS devices using heterogeneous assembly at chip and package-level. First, the performance of a giant (e.g. about 3 mm in diameter), electrostatically actuated beam steering mirror is presented. It can be rotated about two perpendicular axes to steer an optical beam within an angular cone of up to 60° in vector scan mode with an angular resolution of 1 mrad and a response time of 300 ms. To achieve such angular performance relative to mirror size, the microassembly was performed from sub-components fabricated from 4 different wafers. To combine infrared detection with inertial sensing, an electroplated proof mass was flip-chipped onto a 256×1 pixel uncooled bolometric FPA and released using laser ablation. In addition to the microassembly technology, performance results of packaged devices are presented. Finally, to simulate a 3072×3 pixel uncooled detector for cloud and fire imaging in mid and long-wave IR, the staggered assembly of six 512×3 pixel FPAs with a less than 50 micron pixel co-registration is reported.

The 140 GHZ, 1 MW Gyrotron - Status and Recent Results

Science.gov (United States)

Gantenbein, G.; Dammertz, G.; Illy, S.; Kern, S.; Leonhardt, W.; Piosczyk, B.; Schmid, M.; Thumm, M.; Braune, H.; Erckmann, V.; Laqua, H. P.; Michel, G.; Kasparek, W.; Lechte, C.; Legrand, F.; Lievin, C.; Prinz, O.

2009-04-01

A 10 MW ECRH system is currently under construction for the stellarator W7-X which will be built up and operated by IPP in Greifswald, Germany. The present status of the complete system is reported in [1]. The RF power will be provided by 10 gyrotrons. A European collaboration has been established to develop and build the 10 gyrotrons each with an output power of 1 MW for continuous wave (CW) operation [2]. Nine gyrotrons are being manufactured by Thales Electron Devices (TED), Vélizy, France, one gyrotron was produced by CPI, Palo Alto, CA and passed the acceptance tests at IPP. The acceptance tests of the TED gyrotrons are performed at the test stand at FZK and on site at IPP. The first series tube yielded a total output power of 0.98 MW, with an efficiency of 31 % (without a single stage depressed collector) in short pulse operation and of 0.92 MW in pulses of 1800 s (efficiency of almost 45 % at a depression voltage of 29 kV) [3], The Gaussian mode output power was 0.91 MW. The RF power, measured in a calorimetric load at the end of a 25 m long quasi-optical transmission line with seven mirrors, was 0.87 MW. In this contribution typical results of the next series gyrotrons will be reported.

Concepts for fabrication of inertial fusion energy targets

Energy Technology Data Exchange (ETDEWEB)

Nobile, A. (Arthur), Jr.; Hoffer, J. K. (James K.); Gobby, P. L. (Peter L.); Steckle, W. P. (Warren P.), Jr.; Goodin, D. T. (Daniel T.); Besenbruch, G. E. (Gottfried E.); Schultz, K. R. (Kenneth R.)

2001-01-01

Future inertial fusion energy (IFE) power plants will have a Target Fabrication Facility (TFF) that must produce approximately 500,000 targets per day. To achieve a relatively low cost of electricity, the cost to produce these targets will need to be less than approximately $0.25 per target. In this paper the status on the development of concepts for a TFF to produce targets for a heavy ion fusion (HIF) reactor, such as HYLIFE II, and a laser direct drive fusion reactor such as Sombrero, is discussed. The baseline target that is produced in the HIF TFF is similar to the close-coupled indirect drive target designed by Callahan-Miller and Tabak at Lawrence Livermore Laboratory. This target consists of a cryogenic hohlraum that is made of a metal case and a variety of metal foams and metal-doped organic foams. The target contains a DT-filled CH capsule. The baseline direct drive target is the design developed by Bodner and coworkers at Naval Research Laboratory. HIF targets can be filled with DT before or after assembly of the capsule into the hohlraum. Assembly of targets before filling allows assembly operations to be done at room temperature, but tritium inventories are much larger due to the large volume that the hohlraum occupies in the fill system. Assembly of targets cold after filling allows substantial reduction in tritium inventory, but this requires assembly of targets at cryogenic temperature. A model being developed to evaluate the tritium inventories associated with each of the assembly and fill options indicates that filling targets before assembling the capsule into the hohlraum, filling at temperatures as high as possible, and reducing dead-volumes in the fill system as much as possible offers the potential to reduce tritium inventories to acceptable levels. Use of enhanced DT ice layering techniques, such as infrared layering can reduce tritium inventories significantly by reducing the layering time and therefore the number of capsules being layered

Physics analyses of an accelerator-driven sub-critical assembly

Science.gov (United States)

Naberezhnev, Dmitry G.; Gohar, Yousry; Bailey, James; Belch, Henry

2006-06-01

Physics analyses have been performed for an accelerator-driven sub-critical assembly as a part of the Argonne National Laboratory activity in preparation for a joint conceptual design with the Kharkov Institute of Physics and Technology (KIPT) of Ukraine. KIPT has a plan to construct an accelerator-driven sub-critical assembly targeted towards the medical isotope production and the support of the Ukraine nuclear industry. The external neutron source is produced either through photonuclear reactions in tungsten or uranium targets, or deuteron reactions in a beryllium target. KIPT intends using the high-enriched uranium (HEU) for the fuel of the sub-critical assembly. The main objective of this paper is to study the possibility of utilizing low-enriched uranium (LEU) fuel instead of HEU fuel without penalizing the sub-critical assembly performance, in particular the neutron flux level. In the course of this activity, several studies have been carried out to investigate the main choices for the system's parameters. The external neutron source has been characterized and a pre-conceptual target design has been developed. Several sub-critical configurations with different fuel enrichments and densities have been considered. Based on our analysis, it was shown that the performance of the LEU fuel is comparable with that of the HEU fuel. The LEU fuel sub-critical assembly with 200-MeV electron energy and 100-kW electron beam power has an average total flux of ˜2.50×10 13 n/s cm 2 in the irradiation channels. The corresponding total facility power is ˜204 kW divided into 91 and 113 kW deposited in the target and sub-critical assemblies, respectively.

Analysis and Simulation of Multi-target Echo Signals from a Phased Array Radar

OpenAIRE

Jia Zhen; Zhou Rui

2017-01-01

The construction of digital radar simulation systems has been a research hotspot of the radar field. This paper focuses on theoretical analysis and simulation of multi-target echo signals produced in a phased array radar system, and constructs an array antenna element and a signal generation environment. The antenna element is able to simulate planar arrays and optimizes these arrays by adding window functions. And the signal environment can model and simulate radar transmission signals, rada...

Unlearning in feed-forward multi-nets

NARCIS (Netherlands)

Spaanenburg, L; Kurkova,; Steele, NC; Neruda, R; Karny, M

2001-01-01

Multi-nets promise an improved performance over monolithic neural networks by virtue of their distributed implementation. Modular neural networks are multi-nets based on an judicious assembly of functionally different parts. This can be viewed as again a monolithic network, but with more complex

The 2009 MW MW 6.1 L'Aquila fault system imaged by 64k earthquake locations

International Nuclear Information System (INIS)

Valoroso, Luisa

2016-01-01

On April 6 2009, a MW 6.1 normal-faulting earthquake struck the axial area of the Abruzzo region in central Italy. We investigate the complex architecture and mechanics of the activated fault system by using 64k high-resolution foreshock and aftershock locations. The fault system is composed by two major SW dipping segments forming an en-echelon NW trending system about 50 km long: the high-angle L’Aquila fault and the listric Campotosto fault, located in the first 10 km depth. From the beginning of 2009, fore shocks activated the deepest portion of the main shock fault. A week before the MW 6.1 event, the largest (MW 4.0) foreshock triggered seismicity migration along a minor off-fault segment. Seismicity jumped back to the main plane a few hours before the main shock. High-precision locations allowed to peer into the fault zone showing complex geological structures from the metre to the kilometre scale, analogous to those observed by field studies and seismic profiles. Also, we were able to investigate important aspects of earthquakes nucleation and propagation through the upper crust in carbonate-bearing rocks such as: the role of fluids in normal-faulting earthquakes; how crustal faults terminate at depths; the key role of fault zone structure in the earthquake rupture evolution processes.

Load Assembly Design of the FAST Machine

International Nuclear Information System (INIS)

Cucchiaro, A.; Albanese, R.; Ambrosino, G.; Brolatti, G.; Calabro, G.; Cocilovo, V.; Coletti, A.; Coletti, R.; Costa, P.; Frosi, P.; Crescenzi, F.; Crisanti, F.; Granucci, G.; Maddaluno, G.; Pericoli Ridolfini, V.; Pizzuto, A.; Rita, C.; Ramogida, G.

2008-01-01

The FAST [1][2] (Fusion Advanced Studies Torus) load assembly, which includes the Vacuum Vessel (VV) and its internal components, the magnet system and the poloidal field coils, is presented in this paper. FAST operates at a wide range [3][4] of parameters from high performance H-Mode (B T up to 8.5 T; I P up to 8 MA) as well as Advance Tokamak operation (I P =3 MA), and full non inductive current scenario (I P =2 MA). Helium gas at 30K is used for cooling the resistive copper magnets. That allows for a pulse duration up to 170 s (∼ 40 times τres) at 3MA/ 3.5T. To limit the TF magnet ripple ferromagnetic within acceptable values insert have been introduced inside the outboard area of the VV. The VV, segmented by 20 degree modules, is capable to accommodate 40 MW RF power systems. The machine has been designed to house10 MW Negative Neutral Beam injection (NNBI) systems. Tungsten (W) and Liquid Lithium (L-Li) have been chosen as the divertor plates material, and Argon and Neon as the injected impurities to mitigate the thermal loads

AVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders.

Science.gov (United States)

Ivachtchenko, Alexandre V; Lavrovsky, Yan; Okun, Ilya

2016-05-25

Lack of efficacy of many new highly selective and specific drug candidates in treating diseases with poorly understood or complex etiology, as are many of central nervous system (CNS) diseases, encouraged an idea of developing multi-modal (multi-targeted) drugs. In this manuscript, we describe molecular pharmacology, in vitro ADME, pharmacokinetics in animals and humans (part of the Phase I clinical studies), bio-distribution, bioavailability, in vivo efficacy, and safety profile of the multimodal drug candidate, AVN-101. We have carried out development of a next generation drug candidate with a multi-targeted mechanism of action, to treat CNS disorders. AVN-101 is a very potent 5-HT7 receptor antagonist (Ki = 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (Ki = 1.2-2.0 nM). AVN-101 also exhibits a rather high affinity toward histamine H1 (Ki = 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki = 0.41-3.6 nM) receptors. AVN-101 shows a good oral bioavailability and facilitated brain-blood barrier permeability, low toxicity, and reasonable efficacy in animal models of CNS diseases. The Phase I clinical study indicates the AVN-101 to be well tolerated when taken orally at doses of up to 20 mg daily. It does not dramatically influence plasma and urine biochemistry, nor does it prolong QT ECG interval, thus indicating low safety concerns. The primary therapeutic area for AVN-101 to be tested in clinical trials would be Alzheimer's disease. However, due to its anxiolytic and anti-depressive activities, there is a strong rational for it to also be studied in such diseases as general anxiety disorders, depression, schizophrenia, and multiple sclerosis.

Single molecule sequencing-guided scaffolding and correction of draft assemblies.

Science.gov (United States)

Zhu, Shenglong; Chen, Danny Z; Emrich, Scott J

2017-12-06

Although single molecule sequencing is still improving, the lengths of the generated sequences are inevitably an advantage in genome assembly. Prior work that utilizes long reads to conduct genome assembly has mostly focused on correcting sequencing errors and improving contiguity of de novo assemblies. We propose a disassembling-reassembling approach for both correcting structural errors in the draft assembly and scaffolding a target assembly based on error-corrected single molecule sequences. To achieve this goal, we formulate a maximum alternating path cover problem. We prove that this problem is NP-hard, and solve it by a 2-approximation algorithm. Our experimental results show that our approach can improve the structural correctness of target assemblies in the cost of some contiguity, even with smaller amounts of long reads. In addition, our reassembling process can also serve as a competitive scaffolder relative to well-established assembly benchmarks.

[Targeted public funding for health research in the Netherlands].

Science.gov (United States)

Viergever, Roderik F; Hendriks, Thom C C

2014-01-01

The Dutch government funds health research in several ways. One component of public funding consists of funding programmes issued by the Netherlands Organisation for Health Research and Development (ZonMw). The majority of ZonMw's programmes provide funding for research in specific health research areas. Such targeted funding plays an important role in addressing knowledge gaps and in generating products for which there is a need. Good governance of the allocation of targeted funding for health research requires three elements: a research agenda, an overview of the health research currently being conducted, and a transparent decision-making process regarding the distribution of funds. In this article, we describe how public funding for health research is organized in the Netherlands and how the allocation of targeted funds is governed. By describing the questions that the current model of governance raises, we take a first step towards a debate about the governance of targeted public funding for health research in the Netherlands.

Medium voltage three-level converters for the grid connection of a multi-MW wind turbine

DEFF Research Database (Denmark)

Senturk, Osman Selcuk; Helle, Lars; Munk-Nielsen, Stig

2009-01-01

Three-level (3L) neutral point clamped (NPC), flying capacitor (FC), and H-bridge (HB) voltage source converters (VSCs) as a grid-side full-scale medium voltage (MV) converter are modeled, controlled, and simulated for the grid connection of a hypothetical 6MW wind turbine. Via the converter...... topological features and the simulation results demonstrating the converter performance, these three 3L-VSCs are discussed and compared in terms of power density and reliability, which can be considered as two of the most important criteria for the converters placed in wind turbine nacelles. Given the grid...... connection circuit (without capacitive switching ripple filters), the 3L-HB-VSC is expected to be superior with respect to power density and reliability over the 3L-NPC- and -FC-VSCs....

Medium Voltage Three-level Converters for the Grid Connection of aMulti-MW Wind Turbine

DEFF Research Database (Denmark)

Senturk, Osman Selcuk; Helle, Lars; Munk-Nielsen, Stig

2009-01-01

Three-level (3L) neutral point clamped (NPC), flying capacitor (FC), and H-bridge (HB) voltage source converters (VSCs) as a grid-side full-scale medium voltage (MV) converter are modeled, controlled, and simulated for the grid connection of a hypothetical 6MW wind turbine. Via the converter...... topological features and the simulation results demonstrating the converter performance, these three 3L-VSCs are discussed and compared in terms of power density and reliability, which can be considered as two of the most important criteria for the converters placed in wind turbine nacelles. Given the grid...... connection circuit (without capacitive switching ripple filters), the 3L-HB-VSC is expected to be superior with respect to power density and reliability over the 3L-NPC- and -FC-VSCs....

The 1.5 MW wind turbine of tomorrow

Energy Technology Data Exchange (ETDEWEB)

De Wolff, T.J.; Sondergaard, H. [Nordtank Energy Group, Richmond, VA (United States)

1996-12-31

The Danish company Nordtank is one of the pioneers within the wind turbine industry. Since 1981 Nordtank has installed worldwide more than 2300 wind turbine generators with a total name plate capacity that is exceeding 350 MW. This paper will describe two major wind turbine technology developments that Nordtank has accomplished during the last year: Site Optimization of Nordtank wind turbines: Nordtank has developed a flexible design concept for its WTGs in the 500/600 kW range, in order to offer the optimal WTG solution for any given site and wind regime. Nordtank`s 1.5 MW wind turbine: In September 1995, Nordtank was the first company to install a commercial 1.5 NM WTG. This paper will document the development process, the design as well as operations of the Nordtank 1.5 MW WTG.

Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease.

Directory of Open Access Journals (Sweden)

Sneha B Bansode

Full Text Available Alzheimer's disease (AD is a complex neurodegenerative disorder involving multiple cellular and molecular processes. The discovery of drug molecules capable of targeting multiple factors involved in AD pathogenesis would greatly facilitate in improving therapeutic strategies. The repositioning of existing non-toxic drugs could dramatically reduce the time and costs involved in developmental and clinical trial stages. In this study, preliminary screening of 140 FDA approved nervous system drugs by docking suggested the viability of the tricyclic group of antidepressants against three major AD targets, viz. Acetylcholinesterase (AChE, β-secretase (BACE-1, and amyloid β (Aβ aggregation, with one member, protriptyline, showing highest inhibitory activity. Detailed biophysical assays, together with isothermal calorimetry, fluorescence quenching experiments, kinetic studies and atomic force microscopy established the strong inhibitory activity of protriptyline against all three major targets. The molecular basis of inhibition was supported with comprehensive molecular dynamics simulations. Further, the drug inhibited glycation induced amyloid aggregation, another important causal factor in AD progression. This study has led to the discovery of protriptyline as a potent multi target directed ligand and established its viability as a promising candidate for AD treatment.

Assembly Test of Elastic Averaging Technique to Improve Mechanical Alignment for Accelerating Structure Assemblies in CLIC

CERN Document Server

Huopana, J

2010-01-01

The CLIC (Compact LInear Collider) is being studied at CERN as a potential multi-TeV e+e- collider [1]. The manufacturing and assembly tolerances for the required RF-components are important for the final efficiency and for the operation of CLIC. The proper function of an accelerating structure is very sensitive to errors in shape and location of the accelerating cavity. This causes considerable issues in the field of mechanical design and manufacturing. Currently the design of the accelerating structures is a disk design. Alternatively it is possible to create the accelerating assembly from quadrants, which favour the mass manufacturing. The functional shape inside of the accelerating structure remains the same and a single assembly uses less parts. The alignment of these quadrants has been previously made kinematic by using steel pins or spheres to align the pieces together. This method proved to be a quite tedious and time consuming method of assembly. To limit the number of different error sources, a meth...

Design, simulation and manufacture of a multi leaf collimator to confirm the target volumes in intensity modulated radiation therapy

International Nuclear Information System (INIS)

Kamali-Asl, A.; Batooli, A. H.; Harriri, S.; Salman-Rezaee, F.; Shahmardan, F.; Yavari, L.

2010-01-01

Intensity modulated radiation therapy is one of the cancer treatment methods. It is important to selectively aim at the target in this way, which can be performed using a multi leaf collimator. Materials and Methods: In order to specifically irradiate the target volume in radiotherapy to reduce the patient absorbed dose, the use of multi leaf collimator has been investigated in this work. Design and simulation of an multi leaf collimator was performed by a Monte Carlo method and the optimum material for manufacturing the leaves was determined using MCNP4C. After image processing (CT or MRI) in this system, the tumor configuration is determined. Then the linear accelerator is switched on and the beam irradiates the cancerous cells. When the multi leaf collimator leaves receive a command from the micro controller, they start to move and absorb the radiation and modulate its intensity. Consequently, the tumor receives maximum intensity of radiation but minimum intensity is delivered to healthy tissues. Results: According to the simulations and calculations, the best material to manufacture the leaves from is tungsten alloy containing copper and nickel which absorbs a large amount of the radiation; by using a 8.65 cm thickness of alloy, 10.55% of radiation will transmit through the leaves. Discussion and Conclusion: Lead blocks are conventionally used in radiotherapy. However, they have some problems like cost, storage and manufacture for every patient. Certainly, the multi leaf collimator is the most efficient device to specifically irradiate the tumor in Intensity modulated radiation therapy. Furthermore, it facilitates treating the target in different views by rotation around the patient. Thus the patient's absorbed dose will decrease and the tumor will receive maximum dose.

Evaluation of glycodendron and synthetically-modified dextran clearing agents for multi-step targeting of radioisotopes for molecular imaging and radioimmunotherapy

Science.gov (United States)

Cheal, Sarah M.; Yoo, Barney; Boughdad, Sarah; Punzalan, Blesida; Yang, Guangbin; Dilhas, Anna; Torchon, Geralda; Pu, Jun; Axworthy, Don B.; Zanzonico, Pat; Ouerfelli, Ouathek; Larson, Steven M.

2014-01-01

A series of N-acetylgalactosamine-dendrons (NAG-dendrons) and dextrans bearing biotin moieties were compared for their ability to complex with and sequester circulating bispecific anti-tumor antibody (scFv4) streptavidin (SA) fusion protein (scFv4-SA) in vivo, to improve tumor to normal tissue concentration ratios for targeted radioimmunotherapy and diagnosis. Specifically, a total of five NAG-dendrons employing a common synthetic scaffold structure containing 4, 8, 16, or 32 carbohydrate residues and a single biotin moiety were prepared (NAGB), and for comparative purposes, a biotinylated-dextran with average molecular weight (MW) of 500 kD was synthesized from amino-dextran (DEXB). One of the NAGB compounds, CA16, has been investigated in humans; our aim was to determine if other NAGB analogs (e.g. CA8 or CA4) were bioequivalent to CA16 and/or better suited as MST reagents. In vivo studies included dynamic positron-emission tomography (PET) imaging of 124I-labelled-scFv4-SA clearance and dual-label biodistribution studies following multi-step targeting (MST) directed at subcutaneous (s.c.) human colon adenocarcinoma xenografts in mice. The MST protocol consists of three injections: first, a bispecific antibody specific for an anti-tumor associated glycoprotein (TAG-72) single chain genetically-fused with SA (scFv4-SA); second, CA16 or other clearing agent; and third, radiolabeled biotin. We observed using PET imaging of 124I-labelled-scFv4-SA clearance that the spatial arrangement of ligands conjugated to NAG (i.e. biotin) can impact the binding to antibody in circulation and subsequent liver uptake of the NAG-antibody complex. Also, NAGB CA32-LC or CA16-LC can be utilized during MST to achieve comparable tumor- to-blood ratios and absolute tumor uptake seen previously with CA16. Finally, DEXB was equally effective as NAGB CA32-LC at lowering scFv4-SA in circulation, but at the expense of reducing absolute tumor uptake of radiolabeled biotin. PMID:24219178

S-band 45 MW peak power test facility at RRCAT

International Nuclear Information System (INIS)

Wanmode, A. Yashwant; Reddy, Sivananda; Mulchandani, J.; Mohania, Praveen; Shrivastava, B. Purushottam

2015-01-01

RRCAT is engaged in the design and development of high energy electron LINAC as future injectors for the Booster Synchrotron for Indus-1 and Indus-2 SRS. The high energy LINAC will need microwave power over 30 MW depending on the number of structures to be energized. In order to have advance preparations for this development a 45 MW S-Band test facility has been designed and developed at RRCAT. The test stand is built around a 45 MW peak power S-band pulsed klystron, A conventional pulse forming network based modulator for klystron has been designed and developed. The WR-284 waveguide transmission system consisting of dual directional couplers, SF 6 gas pressurization unit, high power waveguide load and arc sensor has been developed and interfaced with the klystron. The klystron has been successfully tested up to 30 MW peak power at 2856 MHz on SF 6 pressurized waveguide line. A solid state S Band driver amplifier up to 1 kW output power was designed developed for driving the klystron. This paper describes the results of 30 MW peak power test of this facility. (author)

Reaction of the immune system to low-level RF/MW exposures

International Nuclear Information System (INIS)

Szmigielski, Stanislaw

2013-01-01

Radiofrequency (RF) and microwave (MW) radiation have been used in the modern world for many years. The rapidly increasing use of cellular phones in recent years has seen increased interest in relation to the possible health effects of exposure to RF/MW radiation. In 2011 a group of international experts organized by the IARC (International Agency for Research on Cancer in Lyon) concluded that RF/MW radiations should be listed as a possible carcinogen (group 2B) for humans. The incomplete knowledge of RF/MW-related cancer risks has initiated searches for biological indicators sensitive enough to measure the “weak biological influence” of RF/MWs. One of the main candidates is the immune system, which is able to react in a measurable way to discrete environmental stimuli. In this review, the impacts of weak RF/MW fields, including cell phone radiation, on various immune functions, both in vitro and in vivo, are discussed. The bulk of available evidence clearly indicates that various shifts in the number and/or activity of immunocompetent cells are possible, however the results are inconsistent. For example, a number of lymphocyte functions have been found to be enhanced and weakened within single experiments based on exposure to similar intensities of MW radiation. Certain premises exist which indicate that, in general, short-term exposure to weak MW radiation may temporarily stimulate certain humoral or cellular immune functions, while prolonged irradiation inhibits the same functions

Reaction of the immune system to low-level RF/MW exposures

Energy Technology Data Exchange (ETDEWEB)

Szmigielski, Stanislaw, E-mail: szmigielski@wihe.waw.pl

2013-06-01

Radiofrequency (RF) and microwave (MW) radiation have been used in the modern world for many years. The rapidly increasing use of cellular phones in recent years has seen increased interest in relation to the possible health effects of exposure to RF/MW radiation. In 2011 a group of international experts organized by the IARC (International Agency for Research on Cancer in Lyon) concluded that RF/MW radiations should be listed as a possible carcinogen (group 2B) for humans. The incomplete knowledge of RF/MW-related cancer risks has initiated searches for biological indicators sensitive enough to measure the “weak biological influence” of RF/MWs. One of the main candidates is the immune system, which is able to react in a measurable way to discrete environmental stimuli. In this review, the impacts of weak RF/MW fields, including cell phone radiation, on various immune functions, both in vitro and in vivo, are discussed. The bulk of available evidence clearly indicates that various shifts in the number and/or activity of immunocompetent cells are possible, however the results are inconsistent. For example, a number of lymphocyte functions have been found to be enhanced and weakened within single experiments based on exposure to similar intensities of MW radiation. Certain premises exist which indicate that, in general, short-term exposure to weak MW radiation may temporarily stimulate certain humoral or cellular immune functions, while prolonged irradiation inhibits the same functions.

Development of the C-band (5712 MHz) 50 MW class PPM klystron (2)

International Nuclear Information System (INIS)

Matsumoto, H.; Shintake, T.; Ohkubo, Y.; Taoka, H.; Ohhashi, K.; Kakuno, K.

2001-01-01

Hot isostatic pressing (HIP) technique has been firstly applied to fabricate a magnetic circuit in a PPM klystron. Simply stacking disks of the magnetic stainless-steel (Mag-SUS) and oxygen-free-copper (OFC) alternatively, and processing in a HIP vessel filled with pressurised Ar-gas at 1200-kgf/cm 2 and temperature of 800degC for 2 hours, they were bonded in one block with diffusion bonding. No brazing-alloys were used in this process. After machining the rf-cavities and beam drift-tube on the bonded PPM stack, they were assembled together in one body by means of conventional brazing method. The C-band PPM klystron based on this technique was fabricated in the course of the Linear Collider R and D. Out-put power of 37 MW was generated with 2.5-μsec pulse width and 50 pps repetition rate. (author)

Polymer cantilever platform for dielectrophoretic assembly of carbon nanotubes

DEFF Research Database (Denmark)

Johansson, Alicia; Calleja, M.; Dimaki, Maria

2004-01-01

A polymer cantilever platform for dielectrophoretic assembly of carbon nanotubes has been designed and realized. Multi-walled carbon nanotubes from aqueous solution have been assembled between two metal electrodes that are separated by 2 mu m and embedded in the polymer cantilever. The entire chip......, except for the metallic electrodes and wiring, was fabricated in the photoresist SU-8. SU-8 allows for an inexpensive, flexible and fast fabrication method, and the cantilever platform provides a hydrophobic surface that should be well suited for nanotube assembly. The device can be integrated in a micro...

Heterogeneous assembly for plutonium multi recycling in PWRs: the Corail concept

International Nuclear Information System (INIS)

Youinou, G.; Zaetta, A.; Vasile, A.; Delpech, M.; Rohart, M.; Guillet, J.L.

2001-01-01

The CORAIL assembly is a standard 17 x 17 PWR fuel assembly containing 180 UO 2 rods and 84 MOX rods located at the periphery to limit the hot-channel factor. After many recycling, the plutonium content stabilizes around 8% and the U 235 enrichment around 4.8% (for a 3 u 15000 MWd/t fuel cycle length). An all-CORAIL park would have a zero plutonium mass balance, and compared with an all-UO 2 park the gain in terms of Separating Work Units and natural uranium would be between 15% and 20%. Detailed calculations of a 1300 MWe PWR loaded with such assemblies show that its control would not require the use of enriched boron. Burnable poison is necessary to limit the hot-channel factor. (author)

A neutron production target for ESS based upon the Canned-rods concept

International Nuclear Information System (INIS)

Ghiglino, A.; Terrón, S.; Thomsen, K.; Wolters, J.; Magán, M.; Martínez, F.; Vicente, P.J. de; Vivanco, R.; Sordo, F.; Butzek, M.; Perlado, J.M.; Bermejo, F.J.

2014-01-01

The neutron production targets operating within the present day spallation neutron sources in the MW power range are either based on water-cooled solid state devices such as that implemented at the SINQ source at PSI or liquid metal loops such as those installed at SNS and MLSF. Here we describe a water-cooled rotating solid target as an option for the 5 MW ESS project as an alternative to the current design based upon a helium-cooled solid rotating target. Implementation of the proposed option would provide comparable neutronic performance to that of the gas-cooled concept and furthermore, it would involve a relatively straightforward adaptation of the current ESS baseline geometry

Topology of classical molecular optimal control landscapes for multi-target objectives

Energy Technology Data Exchange (ETDEWEB)

Joe-Wong, Carlee [Program in Applied and Computational Mathematics, Princeton University, Princeton, New Jersey 08544-1000 (United States); Ho, Tak-San; Rabitz, Herschel, E-mail: hrabitz@princeton.edu [Department of Chemistry, Princeton University, Princeton, New Jersey 08544-1009 (United States); Wu, Rebing [Department of Automation, Tsinghua University, Beijing (China)

2015-04-21

This paper considers laser-driven optimal control of an ensemble of non-interacting molecules whose dynamics lie in classical phase space. The molecules evolve independently under control to distinct final states. We consider a control landscape defined in terms of multi-target (MT) molecular states and analyze the landscape as a functional of the control field. The topology of the MT control landscape is assessed through its gradient and Hessian with respect to the control. Under particular assumptions, the MT control landscape is found to be free of traps that could hinder reaching the objective. The Hessian associated with an optimal control field is shown to have finite rank, indicating an inherent degree of robustness to control noise. Both the absence of traps and rank of the Hessian are shown to be analogous to the situation of specifying multiple targets for an ensemble of quantum states. Numerical simulations are presented to illustrate the classical landscape principles and further characterize the system behavior as the control field is optimized.

Towards assembly completion and preparation of experimental campaigns of Wendelstein 7-X in the perspective of a path to a stellarator fusion power plant

Energy Technology Data Exchange (ETDEWEB)

Klinger, T., E-mail: thomas.klinger@ipp.mpg.de; Baylard, C.; Beidler, C.D.; Boscary, J.; Bosch, H.S.; Dinklage, A.; Hartmann, D.; Helander, P.; Maßberg, H.; Peacock, A.; Pedersen, T.S.; Rummel, T.; Schauer, F.; Wegener, L.; Wolf, R.

2013-10-15

superconducting current leads, one pair for each coil type; and (c) assembly of the device periphery including diagnostics and heating systems. In the second part we report on the present status of planning for the first operation phase (5–10 s discharge duration at 8 MW heating power), the completion and hardening of the device for full power steady-state operation, and the second operation phase (up to 30 min discharge duration at 10 MW heating power). It is the ultimate goal of operation phase one to develop credible and robust discharge scenarios for the high-power steady-state operation phase two. Beyond the improved equilibrium, confinement, and stability properties owing to stellarator optimization, this requires density control, impurity control, edge iota control as well as high density microwave heating. Of paramount importance is the operation of the island divertor, which is realized in the first operation phase as an inertially cooled conventional graphite target divertor. It will be replaced later on by the steady-state capable island divertor with its water-cooled carbon fiber reinforced carbon target elements.

SAR Target Recognition via Local Sparse Representation of Multi-Manifold Regularized Low-Rank Approximation

Directory of Open Access Journals (Sweden)

Meiting Yu

2018-02-01

Full Text Available The extraction of a valuable set of features and the design of a discriminative classifier are crucial for target recognition in SAR image. Although various features and classifiers have been proposed over the years, target recognition under extended operating conditions (EOCs is still a challenging problem, e.g., target with configuration variation, different capture orientations, and articulation. To address these problems, this paper presents a new strategy for target recognition. We first propose a low-dimensional representation model via incorporating multi-manifold regularization term into the low-rank matrix factorization framework. Two rules, pairwise similarity and local linearity, are employed for constructing multiple manifold regularization. By alternately optimizing the matrix factorization and manifold selection, the feature representation model can not only acquire the optimal low-rank approximation of original samples, but also capture the intrinsic manifold structure information. Then, to take full advantage of the local structure property of features and further improve the discriminative ability, local sparse representation is proposed for classification. Finally, extensive experiments on moving and stationary target acquisition and recognition (MSTAR database demonstrate the effectiveness of the proposed strategy, including target recognition under EOCs, as well as the capability of small training size.

TRIGA 14 MW Research Reactor Status and Utilization

International Nuclear Information System (INIS)

Barbos, D.; Ciocanescu, M.; Paunoiu, C.

2016-01-01

Institute for Nuclear Research is the owner of the largest family TRIGA research reactor, TRIGA14 MW research reactor. TRIGA14 MW reactor was designed to be operated with HEU nuclear fuel but now the reactor core was fully converted to LEU nuclear fuel. The full conversion of the core was a necessary step to ensure the continuous operation of the reactor. The core conversion took place gradually, using fuel manufactured in different batches by two qualified suppliers based on the same well qualified technology for TRIGA fuel, including some variability which might lead to a peculiar behaviour under specific conditions of reactor utilization. After the completion of the conversion a modernization program for the reactor systems was initiated in order to achieve two main objectives: safe operation of the reactor and reactor utilization in a competitive environment to satisfy the current and future demands and requirements. The 14 MW TRIGA research reactor operated by the Institute for Nuclear Research in Pitesti, Romania, is a relatively new reactor, commissioned 37 years ago. It is expected to operate for another 15-20 years, sustaining new fuel and testing of materials for future generations of power reactors, supporting radioisotopes production through the development of more efficient new technologies, sustaining research or enhanced safety, extended burn up and verification of new developments concerning nuclear power plants life extension, to sustain neutron application in physics research, thus becoming a centre for instruction and training in the near future. A main objective of the TRIGA14MW research reactor is the testing of nuclear fuel and nuclear material. The TRIGA 14 MW reactor is used for medical and industrial radioisotopes production ( 131 I, 125 I, 192 Ir etc.) and a method for 99 Mo- 99 Tc production from fission is under development. For nuclear materials properties investigation, neutron radiography methods have been developed in the INR. The

Saturn V First Stage (S-1C) Ready for Assembly AT KSC

Science.gov (United States)

1968-01-01

This photograph shows the Saturn V first stage (S-1C) in the Vehicle Assembly Building at Kennedy Space Center ready to be mated with the second and third stages to complete the assembly of a Saturn V launch vehicle. This particular Saturn V was used for Apollo 6, which was a systems test flight. The towering 363-foot Saturn V was a multi-stage, multi-engine launch vehicle standing taller than the Statue of Liberty. Altogether, the Saturn V engines produced as much power as 85 Hoover Dams.

HPP Boshkov Most - upgrading the designed installed capacity from 45 MW to 70 MW

International Nuclear Information System (INIS)

Pavleski, Vlatko; Jakimova-Filipovska, Nevenka; Ivanova-Davidovikj, Jasna

2004-01-01

HPP Boskov Most location will be near the town of Debar, accessible from the Mavrovo-Debar road. This Project involves the tributaries that combine to make tip the Mala Reka, the biggest tributary to Radika river. The watershed area is characterized as having high mountains and rich watercourses, without major settlements. The hydro system consists of: The Tresonce Reservoir with 44 m high dam, with an intake to a head race tunnel, also additional intakes linked by a system of siphons, covered channels collect the waters from high mountains and deliver their flow to the head- race tunnel. The head race tunnel ends with surge shaft and pen stock to the powerhouse. In this paper will be given differences between the Main Design prepared by HEP - Skopje in 1983, where the installed capacity is 45 MW and Feasibility Study prepared by Paul C. Rizzo Ass., where installed capacity is suggested to be 70 MW through enlarged nominal discharge - from 14 m 3 /s to 22 m 3 /s. (Author)

HPP Boshkov Most - upgrading of the design installed capacity from 45 MW to 70 MW

International Nuclear Information System (INIS)

Pavleski, Vlatko; Jakimova Filipovska, Nevenka; Ivanova-Davidovicj, Jasna

2007-01-01

HPP Boshkov Most location will be near the town of Debar, accessible from Mavrovo-Debar road. This procject involves the tributaries that combine to make up the Mala Reka, the biggest tributary to Radika river. The watershed area is characterized as having high mountains and rich watercourses, without major settlements. The hydro system consists of: The Tresonche reservoir with 44 m high dam, with an intake to head race tunnel, also additional intakes linked by a system siphons, covered channels collect the waters from high mountains and deliver their flow to the head race tunnel. The head race tunnel ends with surge shaft and penstocks to the powerhouse. In this paper will be given differences between the Main Design prepared by HEP - Skopje in 1983, where the installed capacity is 45 MW and feasibility Study prepared by Pall C. Rizzo Ass., where installed capacity is suggested to be 70 MW, thru enlarged nominal discharge - from 14 m 3 /s to 22 m 3 /s. (Author)

MW-Class Electric Propulsion System Designs

Science.gov (United States)

LaPointe, Michael R.; Oleson, Steven; Pencil, Eric; Mercer, Carolyn; Distefano, Salvador

2011-01-01

Electric propulsion systems are well developed and have been in commercial use for several years. Ion and Hall thrusters have propelled robotic spacecraft to encounters with asteroids, the Moon, and minor planetary bodies within the solar system, while higher power systems are being considered to support even more demanding future space science and exploration missions. Such missions may include orbit raising and station-keeping for large platforms, robotic and human missions to near earth asteroids, cargo transport for sustained lunar or Mars exploration, and at very high-power, fast piloted missions to Mars and the outer planets. The Advanced In-Space Propulsion Project, High Efficiency Space Power Systems Project, and High Power Electric Propulsion Demonstration Project were established within the NASA Exploration Technology Development and Demonstration Program to develop and advance the fundamental technologies required for these long-range, future exploration missions. Under the auspices of the High Efficiency Space Power Systems Project, and supported by the Advanced In-Space Propulsion and High Power Electric Propulsion Projects, the COMPASS design team at the NASA Glenn Research Center performed multiple parametric design analyses to determine solar and nuclear electric power technology requirements for representative 300-kW class and pulsed and steady-state MW-class electric propulsion systems. This paper describes the results of the MW-class electric power and propulsion design analysis. Starting with the representative MW-class vehicle configurations, and using design reference missions bounded by launch dates, several power system technology improvements were introduced into the parametric COMPASS simulations to determine the potential system level benefits such technologies might provide. Those technologies providing quantitative system level benefits were then assessed for technical feasibility, cost, and time to develop. Key assumptions and primary

Multi-data integration of exploration criteria and selection of prospecting targets

International Nuclear Information System (INIS)

Dechang, L.; Jingke, Z.; Maorong, S.; Guojuan, W.

1991-01-01

In this paper based on the analysis of the exploration criteria for Shengyuan Basin-a uranium ore field, the multi-data integration and information extraction of exploration criteria are carried out on computer and image processing system so that the areas with best combinations of exploration criteria are directly displayed on the screen. Six prospecting targets are selected through the field examination. Shengyuan basin in Jiangxi province is a uranium-producing, Jurassic Cretaceous volcanic-sedimentary basin with an area of about 400 sq km. Its basement consists of Sinian-Cambrian rocks with Caledonian granites intruded. Several uranium deposits, occurrences and anomalies were discovered over the basin region which, therefore, becomes a very important uranium ore field in China

Template Assembly for Detailed Urban Reconstruction

KAUST Repository

Nan, Liangliang

2015-05-04

We propose a new framework to reconstruct building details by automatically assembling 3D templates on coarse textured building models. In a preprocessing step, we generate an initial coarse model to approximate a point cloud computed using Structure from Motion and Multi View Stereo, and we model a set of 3D templates of facade details. Next, we optimize the initial coarse model to enforce consistency between geometry and appearance (texture images). Then, building details are reconstructed by assembling templates on the textured faces of the coarse model. The 3D templates are automatically chosen and located by our optimization-based template assembly algorithm that balances image matching and structural regularity. In the results, we demonstrate how our framework can enrich the details of coarse models using various data sets.

Thermodynamic and structural signatures of water-driven methane-methane attraction in coarse-grained mW water.

Science.gov (United States)

Song, Bin; Molinero, Valeria

2013-08-07

Hydrophobic interactions are responsible for water-driven processes such as protein folding and self-assembly of biomolecules. Microscopic theories and molecular simulations have been used to study association of a pair of methanes in water, the paradigmatic example of hydrophobic attraction, and determined that entropy is the driving force for the association of the methane pair, while the enthalpy disfavors it. An open question is to which extent coarse-grained water models can still produce correct thermodynamic and structural signatures of hydrophobic interaction. In this work, we investigate the hydrophobic interaction between a methane pair in water at temperatures from 260 to 340 K through molecular dynamics simulations with the coarse-grained monatomic water model mW. We find that the coarse-grained model correctly represents the free energy of association of the methane pair, the temperature dependence of free energy, and the positive change in entropy and enthalpy upon association. We investigate the relationship between thermodynamic signatures and structural order of water through the analysis of the spatial distribution of the density, energy, and tetrahedral order parameter Qt of water. The simulations reveal an enhancement of tetrahedral order in the region between the first and second hydration shells of the methane molecules. The increase in tetrahedral order, however, is far from what would be expected for a clathrate-like or ice-like shell around the solutes. This work shows that the mW water model reproduces the key signatures of hydrophobic interaction without long ranged electrostatics or the need to be re-parameterized for different thermodynamic states. These characteristics, and its hundred-fold increase in efficiency with respect to atomistic models, make mW a promising water model for studying water-driven hydrophobic processes in more complex systems.

Structural Optimization of an Innovative 10 MW Wind Turbine Nacelle

DEFF Research Database (Denmark)

Dabrowski, Dariusz; Natarajan, Anand; Stehouwer, Ewoud

2015-01-01

For large wind turbine configurations of 10 MW and higher capacities, direct-drives present a more compact solution over conventional geared drivetrains. Further, if the generator is placed in front of the wind turbine rotor, a compact “king-pin” drive is designed, that allows the generator...... to be directly coupled to the hub. In presented study, the structural re-design of the innovative 10 MW nacelle was made using extreme loads obtained from a 10 MW reference wind turbine. On the basis of extreme loads the ultimate stresses on critical nacelle components were determined to ensure integrity...

Two-level MOC calculation scheme in APOLLO2 for cross-section library generation for LWR hexagonal assemblies

International Nuclear Information System (INIS)

Petrov, Nikolay; Todorova, Galina; Kolev, Nikola; Damian, Frederic

2011-01-01

The accurate and efficient MOC calculation scheme in APOLLO2, developed by CEA for generating multi-parameterized cross-section libraries for PWR assemblies, has been adapted to hexagonal assemblies. The neutronic part of this scheme is based on a two-level calculation methodology. At the first level, a multi-cell method is used in 281 energy groups for cross-section definition and self-shielding. At the second level, precise MOC calculations are performed in a collapsed energy mesh (30-40 groups). In this paper, the application and validation of the two-level scheme for hexagonal assemblies is described. Solutions for a VVER assembly are compared with TRIPOLI4® calculations and direct 281g MOC solutions. The results show that the accuracy is close to that of the 281g MOC calculation while the CPU time is substantially reduced. Compared to the multi-cell method, the accuracy is markedly improved. (author)

Self-Assembly of DNA-Coated Particles: Experiment, Simulation and Theory

Science.gov (United States)

Song, Minseok

complementary ssDNA functionality on individual particles ('multi-flavoring') as opposed to functionalization of particles with the same type of ssDNA ('uni-flavoring') is explored as a possible design handle for tuning interparticle interactions and, thereby, accessing diverse structures. We employ a combination of simulations, theory, and experimental validation toward establishing 'multi-flavoring' as a rational design strategy. Firstly, MD simulations are carried out using effective pair potentials to describe interparticle interactions that are representative of different degrees of ssDNA 'multi-flavoring'. These simulations reveal the template-free assembly of a diversity of 2D crystal polymorphs that is apparently tunable by controlling the relative attractive strengths between like and unlike functionalized particles. The resulting phase diagrams predict conditions (i.e., strengths of relative interparticle interactions) for obtaining crystalline phases with lattice symmetries ranging among square, alternating string hexagonal, random hexagonal, rhombic, honeycomb, and even kagome. Finally, these model findings are translated to experiments, in which binary microparticles are decorated with a tailored mixture of two different complementary ssDNA strands as a straight-forward means to realize tunable particle interactions. Guided by simple statistical mechanics and the detailed MD simulations, 'multi-flavoring' and control of solution phase particle stoichiometry resulted in experimental realization of structurally diverse 2D microparticle assemblies consistent with predictions, such as square, pentagonal and hexagonal lattices (honeycomb, kagome). The combined simulation, theory, and experimental findings reveal how control of interparticle interactions via DNA-functionalized particle "multi-flavoring" can lead to an even wider range of accessible colloidal crystal structures. The 2D experiments coupled with the model predictions may be used to provide new fundamental

Lightweight MgB2 superconducting 10 MW wind generator

Science.gov (United States)

Marino, I.; Pujana, A.; Sarmiento, G.; Sanz, S.; Merino, J. M.; Tropeano, M.; Sun, J.; Canosa, T.

2016-02-01

The offshore wind market demands a higher power rate and more reliable turbines in order to optimize capital and operational costs. The state-of-the-art shows that both geared and direct-drive conventional generators are difficult to scale up to 10 MW and beyond due to their huge size and weight. Superconducting direct-drive wind generators are considered a promising solution to achieve lighter weight machines. This work presents an innovative 10 MW 8.1 rpm direct-drive partial superconducting generator using MgB2 wire for the field coils. It has a warm iron rotor configuration with the superconducting coils working at 20 K while the rotor core and the armature are at ambient temperature. A cooling system based on cryocoolers installed in the rotor extracts the heat from the superconducting coils by conduction. The generator's main parameters are compared against a permanent magnet reference machine, showing a significant weight and size reduction. The 10 MW superconducting generator concept will be experimentally validated with a small-scale magnetic machine, which has innovative components such as superconducting coils, modular cryostats and cooling systems, and will have similar size and characteristics as the 10 MW generator.

Free electron laser with small period wiggler and sheet electron beam: A study of the feasibility of operation at 300 GHz with 1 MW CW output power

International Nuclear Information System (INIS)

Booske, J.H.; Granatstein, V.L.; Antonsen, T.M. Jr.

1988-01-01

The use of a small period wiggler (/ell//sub ω/ 2 ). Based on these encouraging results, a proof-of-principle experiment is being assembled, and is aimed at demonstrating FEL operating at 120 GHz with 300 kW output power in 1 μs pulses: electron energy would be 410 keV. Preliminary design of a 300 GHz 1 MW FEL with an untapered wiggler is also presented. 10 refs., 5 figs., 3 tabs

Estimation of cost development of offshore wind energy in the Netherlands and required governmental contribution to realize 6,000 MW in 2020

International Nuclear Information System (INIS)

De Vries, H.J.; Van Sambeek, E.J.W.

2004-04-01

The development of the cost of the production of electricity from offshore wind sources is explored. These cost developments are used to estimate the cost of the Dutch Government to fulfil its self-set target of 6,000 MW offshore wind energy capacity in 2020 [nl

An introduction to the analysis of multi-cavity prestressed concrete pressure vessels

International Nuclear Information System (INIS)

Silva, M.C.A.T. da.

1986-01-01

The present work is a study of multi-cavity prestressed concrete pressure vessels (PCRV) for nuclear reactors. A review is made of the designs, analises and models of multi-cavity concrete pressure vessels. A preliminary evaluation of the NONSAP program for applications in complex three-dimensional structures such as a multi-cavity pressure vessel is also made. A model of a PCRV of a 1000 MW(e) high-temperature gas cooled reactor was selected for a three-dimensional analysis with the NONSAP program. The results obtained are compared with experimental data. (Author) [pt

Assembly and Stacking of Flow-through Enzymatic Bioelectrodes for High Power Glucose Fuel Cells.

Science.gov (United States)

Abreu, Caroline; Nedellec, Yannig; Gross, Andrew J; Ondel, Olivier; Buret, Francois; Goff, Alan Le; Holzinger, Michael; Cosnier, Serge

2017-07-19

Bioelectrocatalytic carbon nanotube based pellets comprising redox enzymes were directly integrated in a newly conceived flow-through fuel cell. Porous electrodes and a separating cellulose membrane were housed in a glucose/oxygen biofuel cell design with inlets and outlets allowing the flow of electrolyte through the entire fuel cell. Different flow setups were tested and the optimized single cell setup, exploiting only 5 mmol L -1 glucose, showed an open circuit voltage (OCV) of 0.663 V and provided 1.03 ± 0.05 mW at 0.34 V. Furthermore, different charge/discharge cycles at 500 Ω and 3 kΩ were applied to optimize long-term stability leading to 3.6 J (1 mW h) of produced electrical energy after 48 h. Under continuous discharge at 6 kΩ, about 0.7 mW h could be produced after a 24 h period. The biofuel cell design further allows a convenient assembly of several glucose biofuel cells in reduced volumes and their connection in parallel or in series. The configuration of two biofuel cells connected in series showed an OCV of 1.35 V and provided 1.82 ± 0.09 mW at 0.675 V, and when connected in parallel, showed an OCV of 0.669 V and provided 1.75 ± 0.09 mW at 0.381 V. The presented design is conceived to stack an unlimited amount of biofuel cells to reach the necessary voltage and power for portable electronic devices without the need for step-up converters or energy managing systems.

Impact analysis of spent fuel jacket assemblies

International Nuclear Information System (INIS)

Aramayo, G.A.

1994-01-01

As part of the analyses performed in support of the reracking of the High Flux Isotope Reactor pool, it became necessary to prove the structural integrity of the spent fuel jacket assemblies subjected to gravity drop that result from postulated accidents associated with the handling of these assemblies while submerged in the pool. The spent fuel jacket assemblies are an integral part of the reracking project, and serve to house fuel assemblies. The structure integrity of the jacket assemblies from loads that result from impact from a height of 10 feet onto specified targets has been performed analytically using the computer program LS-DYNA3D. Nine attitudes of the assembly at the time of impact have been considered. Results of the analyses show that there is no failure of the assemblies as a result of the impact scenarios considered

A 2 MW, CW, 170 GHz gyrotron for ITER

International Nuclear Information System (INIS)

Piosczyk, B.; Arnold, A.; Alberti, S.

2003-01-01

A 140 GHz gyrotron for CW operation is under development for the stellarator W7-X. With a prototype tube a microwave output power of about 0.9 MW has been obtained in pulses up to 180 s, limited by the capability of the high voltage power supply. The development work on coaxial cavity gyrotrons has demonstrated the feasibility of manufacturing of a 2 MW, CW 170 GHz tube that could be used for ITER. The problems specific to the coaxial arrangement have been investigated and all relevant information needed for an industrial realization of a coaxial gyrotron have been obtained in short pulse experiments (up to 17 ms). The suitability of critical components for a 2 MW, CW coaxial gyrotron has been studied and a first integrated design has been done. (author)

Inverse Problem in Self-assembly

Science.gov (United States)

Tkachenko, Alexei

2012-02-01

By decorating colloids and nanoparticles with DNA, one can introduce highly selective key-lock interactions between them. This leads to a new class of systems and problems in soft condensed matter physics. In particular, this opens a possibility to solve inverse problem in self-assembly: how to build an arbitrary desired structure with the bottom-up approach? I will present a theoretical and computational analysis of the hierarchical strategy in attacking this problem. It involves self-assembly of particular building blocks (``octopus particles''), that in turn would assemble into the target structure. On a conceptual level, our approach combines elements of three different brands of programmable self assembly: DNA nanotechnology, nanoparticle-DNA assemblies and patchy colloids. I will discuss the general design principles, theoretical and practical limitations of this approach, and illustrate them with our simulation results. Our crucial result is that not only it is possible to design a system that has a given nanostructure as a ground state, but one can also program and optimize the kinetic pathway for its self-assembly.