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Sample records for mt clemens michigan

  1. Liivimaa päritolu saksa keele õpetaja Tallinnas / Clemens Krause ; vahendas Ülo Tikk

    Index Scriptorium Estoniae

    Krause, Clemens Hermann, 1943-

    1998-01-01

    Intervjuu Tallinna 54. Keskkoolis saksakeelset osakonda juhatava endise Düsseldorfi koolidirektori Clemens Krausega saksakeelse osakonna tööst, Saksa ja Eesti hariduselu sarnasustest ja erinevustest

  2. Te schepe waert. Overwegingen bij de reconstructie van een zot polyfoon lied van Clemens non Papa

    NARCIS (Netherlands)

    Grijp, L.P.; van Maas e.a., S.

    2012-01-01

    Clemens non Papa's vierstemmige 'Te schepe waert' is het eerste lied van de bundel Niewe Duytsche Liedekens, uitgegeven in Maastricht 1554 door Jacob Baethen. Van deze bundel ontbreekt de sopraanpartij. Louis Grijp heeft samen met Nico van der Meel de sopraan gereconstrueerd en hoopt de aldus

  3. Godsspraak als drijfveer, standaard en model voor gebed bij Clemens van Rome aan de Corinthieërs

    Directory of Open Access Journals (Sweden)

    Benno A. Zuiddam

    2015-11-01

    Full Text Available Die eerste brief van Clemens Romanus aan die Korintiërs vertoon ‘n afhankelikheid van heilige Skrif en gebed. In die konteks van hierdie vroegchristelike brief is dit die Skrif wat gebed bevorder en vorm gee. Clemens het vir sy kennis van God staatgemaak op God se skriftelike openbaring, aangesien hy die Skrif beskou as Godsspraak in terme van inhoud en gesag. Die kerkvader nader God daarvolgens in sy gebedsantwoord op die Skrif. Die doel van gebed by die kerkvader is onder meer gerig daarop dat menslike gedrag gehoorsaamheid moet vertoon aan God se geopenbaarde Woord. Die vorm van gebed in Clemens se eerste brief aan die Korintiërs is dan ook grootliks aan die Skrif ontleen, beid ein die woorde en uitdrukkings wat hy hanteer. Die agenda en die inhoudspunte van gebede in hierdie vroegchristelike brief word ook deur die heilige Skrifte bepaal. Op hierdie wyse is Godsspraak dryfveer, standaard en model vir gebed by dié kerkvader. Clement of Rome’s letter to the Corinthians shows an interdependence of holy Scripture and prayer. In the context of this early Christian epistle, Divine revelation, primarily through Scripture, takes on an initiatory role for prayer. Clement considers the Scriptures as oracles of God in terms of their contents and authority. In his prayer-response to Scripture, both for contents and words, Clement shows himself inspired by holy Scripture. Consequently, Clement’s prayer is aimed at conformity of human behaviour to what he considers God’s revealed standards. As to the format of prayer in Clement to the Corinthians, words and expressions are largely borrowed from the sacred Scriptures. The agenda and themes of prayer in this letter are set by holy Writ as well, reinforcing the role of Scripture as initiator, standard and prototype for prayer, as the early church father reaches out to God.

  4. Metallothionein (MT)-III

    DEFF Research Database (Denmark)

    Carrasco, J; Giralt, M; Molinero, A

    1999-01-01

    Metallothionein-III is a low molecular weight, heavy-metal binding protein expressed mainly in the central nervous system. First identified as a growth inhibitory factor (GIF) of rat cortical neurons in vitro, it has subsequently been shown to be a member of the metallothionein (MT) gene family...... injected rats. The specificity of the antibody was also demonstrated in immunocytochemical studies by the elimination of the immunostaining by preincubation of the antibody with brain (but not liver) extracts, and by the results obtained in MT-III null mice. The antibody was used to characterize...... the putative differences between the rat brain MT isoforms, namely MT-I+II and MT-III, in the freeze lesion model of brain damage, and for developing an ELISA for MT-III suitable for brain samples. In the normal rat brain, MT-III was mostly present primarily in astrocytes. However, lectin staining indicated...

  5. Bathymetry of Lake Michigan

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Bathymetry of Lake Michigan has been compiled as a component of a NOAA project to rescue Great Lakes lake floor geological and geophysical data and make it more...

  6. Empirical yield tables for Michigan.

    Science.gov (United States)

    Jerold T. Hahn; Joan M. Stelman

    1984-01-01

    Describes the tables derived from the 1980 Forest Survey of Michigan and presents ways the tables can be used. These tables are broken down according to Michigan's four Forest Survey Units, 14 forest types, and 5 site-index classes.

  7. Michigan forest statistics, 1980.

    Science.gov (United States)

    Gerhard K. Raile; W. Brad Smith

    1983-01-01

    The fourth inventory of the timber resource of Michigan shows a 7% decline in commercial forest area and a 27% gain in growing-stock volume between 1966 and 1980. Highlights and statistics are presented on area, volume, growth, mortality, removals, utilization, and biomass.

  8. Notes on Michigan Boletaceae

    NARCIS (Netherlands)

    Smith, Alexander H.

    1973-01-01

    Studies have continued on the diversity of the Michigan bolete flora. During the season of 1972 a variety of Boletus affinis Peck having a reticulate stipe was discovered and abundant material of Boletus bicolor var. subreticulatus Smith & Thiers was obtained. Boletus hortonii Smith & Thiers was

  9. Michigan's Forests 2009

    Science.gov (United States)

    Scott A. Pugh; Lawrence D. Pedersen; Douglas C. Heym; Ronald J. Piva; Christopher W. Woodall; Charles J. Barnett; Cassandra M. Kurtz; W. Keith. Moser

    2012-01-01

    The seventh inventory of Michigan's forests, completed in 2009, describes more than 19.9 million acres of forest land. The data in this report are based on visits to 7,516 forested plots from 2005 to 2009. Timberland accounts for 97 percent of this forest land, and 62 percent is privately owned. The sugar maple/beech/yellow birch forest type accounts for 18...

  10. Michigan's forests 2004

    Science.gov (United States)

    Scott A. Pugh; Mark H. Hansen; Lawrence D. Pedersen; Douglas C. Heym; Brett J. Butler; Susan J. Crocker; Dacia Meneguzzo; Charles H. Perry; David E. Haugen; Christopher Woodall; Ed Jepsen

    2009-01-01

    The first annual inventory of Michigan's forests, completed in 2004, covers more than 19.3 million acres of forest land. The data in this report are based on visits to 10,355 forested plots from 2000 to 2004. In addition to detailed information on forest attributes, this report includes data on forest health, biomass, land-use change, and timber-product outputs....

  11. Whiting in Lake Michigan

    Science.gov (United States)

    2002-01-01

    Satellites provide a view from space of changes on the Earth's surface. This series of images from the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) aboard the Orbview-2 satellite shows the dramatic change in the color of Lake Michigan during the summer. The bright color that appears in late summer is probably caused by calcium carbonate-chalk-in the water. Lake Michigan always has a lot of calcium carbonate in it because the floor of the lake is limestone. During most of the year the calcium carbonate remains dissolved in the cold water, but at the end of summer the lake warms up, lowering the solubility of calcium carbonate. As a result, the calcium carbonate precipitates out of the water, forming clouds of very small solid particles that appear as bright swirls from above. The phenomenon is appropriately called a whiting event. A similar event occured in 1999, but appears to have started later and subsided earlier. It is also possible that a bloom of the algae Microcystis is responsible for the color change, but unlikely because of Lake Michigan's depth and size. Microcystis blooms have occured in other lakes in the region, however. On the shore of the lake it is possible to see the cities of Chicago, Illinois, and Milwaukee, Wisconsin. Both appear as clusters of gray-brown pixels. Image courtesy the SeaWiFS Project, NASA/Goddard Space Flight Center, and ORBIMAGE

  12. Michigan E85 Infrastructure

    Energy Technology Data Exchange (ETDEWEB)

    Sandstrom, Matthew M.

    2012-03-30

    This is the final report for a grant-funded project to financially assist and otherwise provide support to projects that increase E85 infrastructure in Michigan at retail fueling locations. Over the two-year project timeframe, nine E85 and/or flex-fuel pumps were installed around the State of Michigan at locations currently lacking E85 infrastructure. A total of five stations installed the nine pumps, all providing cost share toward the project. By using cost sharing by station partners, the $200,000 provided by the Department of Energy facilitated a total project worth $746,332.85. This project was completed over a two-year timetable (eight quarters). The first quarter of the project focused on project outreach to station owners about the incentive on the installation and/or conversion of E85 compatible fueling equipment including fueling pumps, tanks, and all necessary electrical and plumbing connections. Utilizing Clean Energy Coalition (CEC) extensive knowledge of gasoline/ethanol infrastructure throughout Michigan, CEC strategically placed these pumps in locations to strengthen the broad availability of E85 in Michigan. During the first and second quarters, CEC staff approved projects for funding and secured contracts with station owners; the second through eighth quarters were spent working with fueling station owners to complete projects; the third through eighth quarters included time spent promoting projects; and beginning in the second quarter and running for the duration of the project was spent performing project reporting and evaluation to the US DOE. A total of 9 pumps were installed (four in Elkton, two in Sebewaing, one in East Lansing, one in Howell, and one in Whitmore Lake). At these combined station locations, a total of 192,445 gallons of E85, 10,786 gallons of E50, and 19,159 gallons of E30 were sold in all reporting quarters for 2011. Overall, the project has successfully displaced 162,611 gallons (2,663 barrels) of petroleum, and reduced

  13. MICHIGAN: Cyclotron conference

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    A sense of excitement was in the air as cyclotron physicists and engineers from 17 countries convened on 30 April for the opening of the Tenth International Conference on Cyclotrons and Their Applications. Some 50 years after its invention, the redoubtable cyclotron remains a topic of compelling current interest. Cyclotron experts gathered at Michigan State University's Kellogg Center to hear of latest developments, of progress and successes on new machines which had come into operation, of new projects which were underway, and of dreams which lay ahead

  14. MICHIGAN: Cyclotron conference

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1984-10-15

    A sense of excitement was in the air as cyclotron physicists and engineers from 17 countries convened on 30 April for the opening of the Tenth International Conference on Cyclotrons and Their Applications. Some 50 years after its invention, the redoubtable cyclotron remains a topic of compelling current interest. Cyclotron experts gathered at Michigan State University's Kellogg Center to hear of latest developments, of progress and successes on new machines which had come into operation, of new projects which were underway, and of dreams which lay ahead.

  15. 75 FR 41895 - Inteva Products, LLC Adrian, Michigan; Inteva Products, LLC Troy, Michigan; Amended Certification...

    Science.gov (United States)

    2010-07-19

    ... Products, LLC Adrian, Michigan; Inteva Products, LLC Troy, Michigan; Amended Certification Regarding... time period at the Troy, Michigan location of Inteva Products, LLC. The Troy, Michigan location.... Accordingly, the Department is amending the certification to include workers of the Troy, Michigan location of...

  16. Creating a Better Funding System for Michigan

    Science.gov (United States)

    Quinn, Daniel

    2010-01-01

    In 1994, Michigan voters approved a ballot initiative that transferred the power in Michigan's education system from local communities to the state. Proposal A succeeded in slowing the growth of local property taxes and narrowing the gap between the richest and poorest districts in Michigan. However, due to a decade of sluggish economic growth,…

  17. A reactive nitrogen budget for Lake Michigan

    Science.gov (United States)

    The reactive nitrogen budget for Lake Michigan was reviewed and updated, making use of recent estimates of watershed and atmospheric nitrogen loads. The updated total N load to Lake Michigan was approximately double the previous estimate from the Lake Michigan Mass Balance study ...

  18. Domain specific MT in use

    DEFF Research Database (Denmark)

    Offersgaard, Lene; Povlsen, Claus; Almsten, Lisbeth Kjeldgaard

    2008-01-01

    point scale evaluate the sentence from the point of view of the post-editor. The post-editor profile defined by the LSP is based on the experiences of introducing MT in the LSP workflow. The relation between the Translation Edit Rate (TER) scores and “Usability” scores is tested. We find TER a candidate......The paper focuses on domain specific use of MT with a special focus on SMT in the workflow of a Language Service Provider (LSP). We report on the feedback of post-editors using fluency/adequacy evaluation and the evaluation metric ’Usability’, understood in this context as where users on a three...

  19. Pollutant transformations over Lake Michigan

    International Nuclear Information System (INIS)

    Alkezweeny, A.J.; Arbuthnot, D.R.; Busness, K.M.; Easter, R.C.; Hales, J.M.; Lee, R.N.; Young, J.M.

    1979-01-01

    An aircraft, a chartered boat, and a constant altitude balloon were used to study pollutant transformations over Lake Michigan in a Lagrangian frame of reference. The experiments were conducted during the summer under strong atmospheric stability where diffusion and dry deposition of pollutants can be neglected

  20. Michigan School Privatization Survey 2013

    Science.gov (United States)

    Hohman, James M.; Fryzelka, Evan E.

    2014-01-01

    Many of Michigan's public school districts are under substantial fiscal pressures from a combination of declining enrollment and increasing costs, particularly related to employee benefits, but most districts are responding to these challenges. One of the ways that districts can stretch their resources further is through competitive contracting…

  1. Residential Energy Efficiency Potential: Michigan

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Eric J [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-11-22

    Energy used by Michigan single-family homes that can be saved through cost-effective improvements. Prepared by Eric Wilson and Noel Merket, NREL, and Erin Boyd, U.S. Department of Energy Office of Energy Policy and Systems Analysis.

  2. The copper deposits of Michigan

    Science.gov (United States)

    Butler, B.S.; Burbank, W.S.

    1929-01-01

    The copper district of Keweenaw Point, in the northern peninsula of Michigan, is the second largest producer of copper in the world.  The output of the district since 1845 has been more than 7,500,000,000 pounds and showed a rather steady and consistent increase from the beginning of production to the end of the World War in 1918, since which there has been a marked decrease.

  3. Active Traffic Management in Michigan

    OpenAIRE

    Johnson, Pat

    2018-01-01

    The US 23 Flex Route is the first active traffic management (ATM) project in the state of Michigan. This route utilizes overhead lane control gantries equipped with various intelligent transportation system (ITS) equipment to facilitate the following ATM strategies: dynamic shoulder use, dynamic lane control, variable speed advisories, and queue warning. The focus of this presentation is how the project team overcame several challenges during the planning, design, and system management phases...

  4. Electric industry restructuring in Michigan

    International Nuclear Information System (INIS)

    Anon.

    1997-01-01

    This Staff Report suggests a modified approach designed to significantly increase the ability of all customer classes to participate and share in the benefits of competition. The concepts discussed in this Report are designed to ensure that rates are not increased for any customers as a result of restructuring and, where possible, rates are reduced through the use of rate reduction bonds. The program outlined in this Report is designed to fulfill five objectives. First, it protects the interests of smaller customers, including low-income residential customers and senior citizens. Second, the program provides opportunities to strengthen Michigan's business community. Third, the program includes funding for employee retraining to assure that utility employees are not negatively impacted by restructuring. Fourth, the phase-in program provides the utilities with the opportunity to prepare for competition so that they remain Michigan-based companies. Fifth, the program is designed to foster competition upon a level playing field. The Commission has jurisdiction over all investor electric utilities and rural electric cooperatives in Michigan. Municipal electric utilities are not subject to Commission jurisdiction. Although this Report discusses details regarding Consumers Power and Detroit Edison, its concepts and principles are intended to apply to all jurisdictional electric utilities

  5. Patterns in Seismicity at Mt St Helens and Mt Unzen

    Science.gov (United States)

    Lamb, Oliver; De Angelis, Silvio; Lavallee, Yan

    2014-05-01

    Cyclic behaviour on a range of timescales is a well-documented feature of many dome-forming volcanoes. Previous work on Soufrière Hills volcano (Montserrat) and Volcán de Colima (Mexico) revealed broad-scale similarities in behaviour implying the potential to develop general physical models of sub-surface processes [1]. Using volcano-seismic data from Mt St Helens (USA) and Mt Unzen (Japan) this study explores parallels in long-term behaviour of seismicity at two dome-forming systems. Within the last twenty years both systems underwent extended dome-forming episodes accompanied by large Vulcanian explosions or dome collapses. This study uses a suite of quantitative and analytical techniques which can highlight differences or similarities in volcano seismic behaviour, and compare the behaviour to changes in activity during the eruptive episodes. Seismic events were automatically detected and characterized on a single short-period seismometer station located 1.5km from the 2004-2008 vent at Mt St Helens. A total of 714 826 individual events were identified from continuous recording of seismic data from 22 October 2004 to 28 February 2006 (average 60.2 events per hour) using a short-term/long-term average algorithm. An equivalent count will be produced from seismometer recordings over the later stages of the 1991-1995 eruption at MT Unzen. The event count time-series from Mt St Helens is then analysed using Multi-taper Method and the Short-Term Fourier Transform to explore temporal variations in activity. Preliminary analysis of seismicity from Mt St Helens suggests cyclic behaviour of subannual timescale, similar to that described at Volcán de Colima and Soufrière Hills volcano [1]. Frequency Index and waveform correlation tools will be implemented to analyse changes in the frequency content of the seismicity and to explore their relations to different phases of activity at the volcano. A single station approach is used to gain a fine-scale view of variations in

  6. Melanesian mtDNA complexity.

    Directory of Open Access Journals (Sweden)

    Jonathan S Friedlaender

    Full Text Available Melanesian populations are known for their diversity, but it has been hard to grasp the pattern of the variation or its underlying dynamic. Using 1,223 mitochondrial DNA (mtDNA sequences from hypervariable regions 1 and 2 (HVR1 and HVR2 from 32 populations, we found the among-group variation is structured by island, island size, and also by language affiliation. The more isolated inland Papuan-speaking groups on the largest islands have the greatest distinctions, while shore dwelling populations are considerably less diverse (at the same time, within-group haplotype diversity is less in the most isolated groups. Persistent differences between shore and inland groups in effective population sizes and marital migration rates probably cause these differences. We also add 16 whole sequences to the Melanesian mtDNA phylogenies. We identify the likely origins of a number of the haplogroups and ancient branches in specific islands, point to some ancient mtDNA connections between Near Oceania and Australia, and show additional Holocene connections between Island Southeast Asia/Taiwan and Island Melanesia with branches of haplogroup E. Coalescence estimates based on synonymous transitions in the coding region suggest an initial settlement and expansion in the region at approximately 30-50,000 years before present (YBP, and a second important expansion from Island Southeast Asia/Taiwan during the interval approximately 3,500-8,000 YBP. However, there are some important variance components in molecular dating that have been overlooked, and the specific nature of ancestral (maternal Austronesian influence in this region remains unresolved.

  7. Economic impacts of wine tourism in Michigan

    Science.gov (United States)

    Mi-Kyung Kim; Seung Hyun Kim

    2003-01-01

    In Michigan, wine tourism is perceived as increasingly important concept because more and more tourists visit wineries and wine tasting rooms annually. However there have been few studies conducted concerning the economic impacts of wineries in Michigan even though the industry has been recognized as having significant economic impact potential. The primary purpose of...

  8. Special report: Mt. St. Helens

    Science.gov (United States)

    Mt. St Helens Volcano, Cascade Range, Southern Washington, USA (46.20°N, 122.18°W.) All times are local (GMT - 7 h through October 24, GMT - 8 h thereafter. Lava extrusion that probably began October 30 added a new lobe to the composite dome in the crater of Mt. St. Helens. After lava extrusion ended September 10 (see September 22 Eos), rates of deformation in the crater remained low for several weeks, as they had after earlier extrusion episodes. Sulfur dioxide emission ranged from 70 to 190 tons per day between October 9 and 24, but showed no particular trends. Inflation of the dome has caused small thrust faults to form in the surrounding crater floor. In early October the most active thrust, south of the dome, was moving at about 1.5 cm/d, and stations on the north crater rampart showed outward movement of about 0.5 cm/d. By October 24 these rates had increased to 14.5 and 3.5-4 cm/d, respectively, and leveling profiles perpendicular to the dome showed that crater floor tilt rates had reached 400-500 μrad/d, prompting the U.S. Geological Survey (USGS) to issue an advisory prediction of renewed lava extrusion within the next two weeks.

  9. Fish impingement at Lake Michigan power plants

    International Nuclear Information System (INIS)

    Sharma, R.K.; Freeman, R.F.; Spigarelli, S.A.

    1976-01-01

    A study was initiated in 1974 to survey the magnitude and to evaluate the impact of fish impingement at 20 power plants on the Great Lakes. Data on impingement rates, site characteristics, intake designs and operational features have been collected and analyzed. Interpretive analyses of these data are in progress. The objectives of this study were: to summarize fish impingement data for Lake Michigan (16/20 plants surveyed are on Lake Michigan); to assess the significance of total and source-related mortalities on populations of forage and predator species; and to expand the assessment of power plant impingement to include all water intakes on Lake Michigan. Data are tabulated

  10. Michigan transportation facts & figures : public transportation

    Science.gov (United States)

    2002-08-16

    This on-line document is part of a series, Transportation Facts & Figures, by the Michigan Department of Transportation (MDOT). The Public Transit section of Transportation Facts & Figures cover such topics as intercity bus service, intercity rail se...

  11. The role of MT2-MMP in cancer progression

    International Nuclear Information System (INIS)

    Ito, Emiko; Yana, Ikuo; Fujita, Chisato; Irifune, Aiko; Takeda, Maki; Madachi, Ayako; Mori, Seiji; Hamada, Yoshinosuke; Kawaguchi, Naomasa; Matsuura, Nariaki

    2010-01-01

    The role of MT2-MMP in cancer progression remains to be elucidated in spite of many reports on MT1-MMP. Using a human fibrosarcoma cell, HT1080 and a human gastric cancer cell, TMK-1, endogenous expression of MT1-MMP or MT2-MMP was suppressed by siRNA induction to examine the influence of cancer progression in vitro and in vivo. In HT1080 cells, positive both in MT1-MMP and MT2-MMP, the migration as well as the invasion was impaired by MT1-MMP or MT2-MMP suppression. Also cell proliferation in three dimensional (3D) condition was inhibited by MT1-MMP or MT2-MMP suppression and tumor growth in the nude mice transplanted with tumor cells were reduced either MT1-MMP or MT2-MMP suppression with a prolongation of survival time in vivo. MT2-MMP suppression induces more inhibitory effects on 3D proliferation and in vivo tumor growth than MT1-MMP. On the other hand, TMK-1 cells, negative in MT1-MMP and MMP-2 but positive in MT2-MMP, all the migratory, invasive, and 3D proliferative activities in TMK-1 are decreased only by MT2-MMP suppression. These results indicate MT2-MMP might be involved in the cancer progression more than or equal to MT1-MMP independently of MMP-2 and MT1-MMP.

  12. MICHIGAN FARM DATABASE NEW DIRECTIONS FOR 1995

    OpenAIRE

    Nott, Sherrill B.; Hepp, Ralph E.

    1996-01-01

    The purpose of this paper is to provide financial and production performance data for Michigan farms in 1995. Separate sections report on the farm types of Cash Grain, Dairy, Fruit, General Crop, General Livestock, and Swine. This data can be used as a comparative data base for individual farmers to conduct a financial analysis of their own farm to identify strengths and weaknesses. This report can also provide information to those interested in the financial well being of Michigan agricultur...

  13. The presence and near-shore transport of human fecal pollution in Lake Michigan beaches

    Science.gov (United States)

    Molloy, S.L.; Liu, L.B.; Phanikumar, M.S.; Jenkins, T.M.; Wong, M.V.; Rose, J.B.; Whitman, R.L.; Shively, D.A.; Nevers, M.B.

    2005-01-01

    The Great Lakes are a source of water for municipal, agricultural and industrial use, and support significant recreation, commercial and sport fishing industries. Every year millions of people visit the 500 plus recreational beaches in the Great Lakes. An increasing public health risk has been suggested with increased evidence of fecal contamination at the shoreline. To investigate the transport and fate of fecal pollution at Great Lakes beaches and the health risk associated with swimming at these beaches, the near-shore waters of Mt Baldy Beach, Lake Michigan and Trail Creek, a tributary discharging into the lake were examined for fecal pollution indicators. A model of surf zone hydrodynamics coupled with a transport model with first-order inactivation of pollutant was used to understand the relative importance of different processes operating in the surf zone (e.g. physical versus biological processes). The Enterococcus human fecal pollution marker, which targets a putative virulence factor, the enterococcal surface protein (esp) in Enterococcus faecium, was detected in 2/28 samples (7%) from the tributaries draining into Lake Michigan and in 6/30 samples (20%) from Lake Michigan beaches. Preliminary analysis suggests that the majority of fecal indicator bactateria variation and water quality changes at the beaches can be explained by inputs from the influential stream and hydrometeorological conditions. Using modeling methods to predict impaired water quality may help reduce potential health threats to recreational visitors.

  14. Patent documentation - comparison of two MT strategies

    DEFF Research Database (Denmark)

    Offersgaard, Lene; Povlsen, Claus

    2007-01-01

    This paper focuses on two matters: A comparison of how two different MT strategies manage translating the text type of patent documentation and a survey of what is needed to transform a MT research prototype system to a translation application for patent texts. The two MT strategies is represented....... The distinctive text type of patents pose special demands for machine translation and these aspects are discussed based on linguistic observations with focus on the users point of view. Two main demands are automatic pre processing of the documents and implementation of a module which in a flexible and user......-friendly manner offers the opportunity to extend the lexical coverage of the system. These demands and the comparison of the two MT strategies are discussed on the basis of proofread patents....

  15. Developing Representative Michigan Truck Configurations for Bridge Load Rating

    Science.gov (United States)

    2018-02-28

    The objective of this study is to recommend a rating process representative of Michigan load effects for legal and extended permit vehicles. For this study, high fidelity WIM data from 20 Michigan sites were analyzed. Using vehicle weight and configu...

  16. 27 CFR 9.79 - Lake Michigan Shore.

    Science.gov (United States)

    2010-04-01

    ... Michigan Shore. (a) Name. The name of the viticultural area described in this section is “Lake Michigan... southeast along the winding course of the Kalamazoo River for approximately 35 miles until it intersects the...

  17. Market Barriers to Solar in Michigan

    Energy Technology Data Exchange (ETDEWEB)

    Miller, E.; Nobler, E.; Wolf, C.; Doris, E.

    2012-08-01

    The solar industry in the United States is at a turning point; the cost of PV hardware has declined substantially in recent years, placing new attention on reducing the balance of system (BOS) costs of solar that now contribute to a growing percentage of installation expenses. How states address these costs through the creation of a favorable policy and regulatory environment is proving to be a critical determinant of a thriving statewide solar market. This report addresses the permitting and tax issues that may stimulate the solar market growth in Michigan. By making PV installations easier to complete through reduced BOS costs, Michigan would become a more attractive location for manufacturers and installers. As PV module costs decline and BOS costs make up a greater share of the cost of solar, action taken today on these issues will prove beneficial in the long term, providing Michigan an opportunity to establish a leadership position in the solar industry.

  18. Alternaria leaf spot in Michigan and fungicide sensitivity issues

    Science.gov (United States)

    Since 2010 there has been an increase in identification of Alternaria leaf spot on sugar beet in Michigan and other growing regions in the US and Canada. In 2016, the disease was severe enough to cause economic losses in the Michigan growing region. Michigan isolates from sugar beet were examined ...

  19. 44 CFR 15.3 - Access to Mt. Weather.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Access to Mt. Weather. 15.3... HOMELAND SECURITY GENERAL CONDUCT AT THE MT. WEATHER EMERGENCY ASSISTANCE CENTER AND AT THE NATIONAL EMERGENCY TRAINING CENTER § 15.3 Access to Mt. Weather. Mt. Weather contains classified material and areas...

  20. Trends in surface-water quality at selected National Stream Quality Accounting Network (NASQAN) stations, in Michigan

    Science.gov (United States)

    Syed, Atiq U.; Fogarty, Lisa R.

    2005-01-01

    To demonstrate the value of long-term, water-quality monitoring, the Michigan Department of Environmental Quality (MDEQ), in cooperation with the U.S. Geological Survey (USGS), initiated a study to evaluate potential trends in water-quality constituents for selected National Stream Quality Accounting Network (NASQAN) stations in Michigan. The goal of this study is to assist the MDEQ in evaluating the effectiveness of water-pollution control efforts and the identification of water-quality concerns. The study included a total of nine NASQAN stations in Michigan. Approximately 28 constituents were analyzed for trend tests. Station selection was based on data availability, land-use characteristics, and station priority for the MDEQ Water Chemistry Monitoring Project. Trend analyses were completed using the uncensored Seasonal Kendall Test in the computer program Estimate Trend (ESTREND), a software program for the detection of trends in water-quality data. The parameters chosen for the trend test had (1) at least a 5-year period of record (2) about 5 percent of the observations censored at a single reporting limit, and (3) 40 percent of the values within the beginning one-fifth and ending one-fifth of the selected period. In this study, a negative trend indicates a decrease in concentration of a particular constituent, which generally means an improvement in water quality; whereas a positive trend means an increase in concentration and possible degradation of water quality. The results of the study show an overall improvement in water quality at the Clinton River at Mount Clemens, Manistee River at Manistee, and Pigeon River near Caseville. The detected trend for these stations show decreases in concentrations of various constituents such as nitrogen compounds, conductance, sulfate, fecal coliform bacteria, and fecal streptococci bacteria. The negative trend may indicate an overall improvement in agricultural practices, municipal and industrial wastewater

  1. The University of Michigan, Kellogg Building Expansion & Renovation, Ann Arbor, Michigan.

    Science.gov (United States)

    Design Cost Data, 2001

    2001-01-01

    Presents design, construction, and cost data for the University of Michigan's Kellogg Building expansion and renovation project. A list of project manufacturers and suppliers is provided along with four photographs and four floor plans. (GR)

  2. MT-CYB mutations in hypertrophic cardiomyopathy

    DEFF Research Database (Denmark)

    Hagen, Christian M; Aidt, Frederik H; Havndrup, Ole

    2013-01-01

    Mitochondrial dysfunction is a characteristic of heart failure. Mutations in mitochondrial DNA, particularly in MT-CYB coding for cytochrome B in complex III (CIII), have been associated with isolated hypertrophic cardiomyopathy (HCM). We hypothesized that MT-CYB mutations might play an important...... and m.15482T>C; p.S246P were identified. Modeling showed that the p.C93Y mutation leads to disruption of the tertiary structure of Cytb by helix displacement, interfering with protein-heme interaction. The p.S246P mutation induces a diproline structure, which alters local secondary structure and induces...... of HCM patients. We propose that further patients with HCM should be examined for mutations in MT-CYB in order to clarify the role of these variants....

  3. Operability and location of Michigan's timber resource.

    Science.gov (United States)

    Mark H. Hansen; Jerold T. Hahn

    1987-01-01

    Operability is the ease or difficulty of managing or harvesting timber because of physical conditions in the stand or on the site. Data collected during the 1980 Michigan statewide forest inventory were used to examine operability of the timber resource based on seven operability components.

  4. Michigan's forests, 2004: statistics and quality assurance

    Science.gov (United States)

    Scott A. Pugh; Mark H. Hansen; Gary Brand; Ronald E. McRoberts

    2010-01-01

    The first annual inventory of Michigan's forests was completed in 2004 after 18,916 plots were selected and 10,355 forested plots were visited. This report includes detailed information on forest inventory methods, quality of estimates, and additional tables. An earlier publication presented analyses of the inventoried data (Pugh et al. 2009).

  5. Trypanosomes of Bufo americanus from northern Michigan.

    Science.gov (United States)

    Werner, J K; Davis, J S; Slaght, K S

    1988-10-01

    Two hundred one American toads (Bufo americanus) from northern Michigan were examined for blood trypanosomes. Three species, Trypanosoma bufophlebotomi, T. schmidti-like sp. and T. pseudopodia, had prevalences of 27, 16 and 1%, respectively. Cross experimental inoculations showed that T. bufophlebotomi from toads is not the same as T. ranarum found in frogs of the family Ranidae of this region.

  6. Private timberland owners of Michigan, 1994.

    Science.gov (United States)

    Earl C. Leatherberry; Neal P. Kingsley; Thomas W. Birch

    1998-01-01

    Identifies and profiles Michigan's private timberland owners. Estimates the number and distribution of private timberland owners by owner attitudes and objectives concerning forest ownership, management, and use. Provides 45 tables relating to owner and property characteristics for the state and its four survey units.

  7. Demographic characteristics and motivations of Michigan agritourists

    Science.gov (United States)

    Deborah Che; Ann Veeck; Gregory Veeck

    2007-01-01

    Michigan agricultural producers, faced with declining commodity prices, rising production costs, and increased global competition, have looked at agritourism as a way to save the farm as well as provide customers with personalized service; high-quality, fresh food; and farm, nature, and family experiences. While previous research on agritourism indicates that it taps...

  8. Earthworm Lumbricus rubellus MT-2: Metal Binding and Protein Folding of a True Cadmium-MT

    Directory of Open Access Journals (Sweden)

    Gregory R. Kowald

    2016-01-01

    Full Text Available Earthworms express, as most animals, metallothioneins (MTs—small, cysteine-rich proteins that bind d10 metal ions (Zn(II, Cd(II, or Cu(I in clusters. Three MT homologues are known for Lumbricus rubellus, the common red earthworm, one of which, wMT-2, is strongly induced by exposure of worms to cadmium. This study concerns composition, metal binding affinity and metal-dependent protein folding of wMT-2 expressed recombinantly and purified in the presence of Cd(II and Zn(II. Crucially, whilst a single Cd7wMT-2 species was isolated from wMT-2-expressing E. coli cultures supplemented with Cd(II, expressions in the presence of Zn(II yielded mixtures. The average affinities of wMT-2 determined for either Cd(II or Zn(II are both within normal ranges for MTs; hence, differential behaviour cannot be explained on the basis of overall affinity. Therefore, the protein folding properties of Cd- and Zn-wMT-2 were compared by 1H NMR spectroscopy. This comparison revealed that the protein fold is better defined in the presence of cadmium than in the presence of zinc. These differences in folding and dynamics may be at the root of the differential behaviour of the cadmium- and zinc-bound protein in vitro, and may ultimately also help in distinguishing zinc and cadmium in the earthworm in vivo.

  9. Ancient mtDNA genetic variants modulate mtDNA transcription and replication.

    Directory of Open Access Journals (Sweden)

    Sarit Suissa

    2009-05-01

    Full Text Available Although the functional consequences of mitochondrial DNA (mtDNA genetic backgrounds (haplotypes, haplogroups have been demonstrated by both disease association studies and cell culture experiments, it is not clear which of the mutations within the haplogroup carry functional implications and which are "evolutionary silent hitchhikers". We set forth to study the functionality of haplogroup-defining mutations within the mtDNA transcription/replication regulatory region by in vitro transcription, hypothesizing that haplogroup-defining mutations occurring within regulatory motifs of mtDNA could affect these processes. We thus screened >2500 complete human mtDNAs representing all major populations worldwide for natural variation in experimentally established protein binding sites and regulatory regions comprising a total of 241 bp in each mtDNA. Our screen revealed 77/241 sites showing point mutations that could be divided into non-fixed (57/77, 74% and haplogroup/sub-haplogroup-defining changes (i.e., population fixed changes, 20/77, 26%. The variant defining Caucasian haplogroup J (C295T increased the binding of TFAM (Electro Mobility Shift Assay and the capacity of in vitro L-strand transcription, especially of a shorter transcript that maps immediately upstream of conserved sequence block 1 (CSB1, a region associated with RNA priming of mtDNA replication. Consistent with this finding, cybrids (i.e., cells sharing the same nuclear genetic background but differing in their mtDNA backgrounds harboring haplogroup J mtDNA had a >2 fold increase in mtDNA copy number, as compared to cybrids containing haplogroup H, with no apparent differences in steady state levels of mtDNA-encoded transcripts. Hence, a haplogroup J regulatory region mutation affects mtDNA replication or stability, which may partially account for the phenotypic impact of this haplogroup. Our analysis thus demonstrates, for the first time, the functional impact of particular mt

  10. Mapping Lake Michigan Fish Catch Data

    OpenAIRE

    Wodd, Jacob; Doucette, Jarrod; Höök, Tomas O.

    2014-01-01

    The only Great Lake completely contained in the U.S., Lake Michigan offers an abundance of recreational fishing. This project takes 20 years’ worth of salmonid fish catch data, and uses GIS to organize and visually represent the data in a way that is meaningful and helpful to local fisherman and researchers. Species represented included Brown Trout, Lake Trout, Rainbow Trout, Chinook Salmon, and Coho Salmon. The species are organized by both decadal and yearly spans, as well as catch per t...

  11. The Mt Logan Holocene-late Wisconsinan isotope record

    DEFF Research Database (Denmark)

    Dahl-Jensen, Dorthe; Fisher, David; Osterberg, Erich

    2008-01-01

    Mt Logan • stable isotopes • Holocene • ENSO • peat • N Pacific • sudden change Udgivelsesdato: August......Mt Logan • stable isotopes • Holocene • ENSO • peat • N Pacific • sudden change Udgivelsesdato: August...

  12. Plutonium and americium in Lake Michigan sediments

    International Nuclear Information System (INIS)

    Edgington, D.N.; Alberts, J.J.; Wahlgren, M.A.; Karttunen, J.O.; Reeve, C.A.

    1975-01-01

    The vertical distributions of 239 , 240 Pu, 238 Pu, and 137 Cs have been measured in sediment cores taken from Lake Michigan. Sections from a limited number of cores have been analyzed for 241 Am. In addition, grab samples from ten locations in the southern basin of the lake have been analyzed for phase distribution of 239 , 240 Pu using a sequential extraction technique. The results indicate that the 239 , 240 Pu, 238 Pu, and 137 Cs from weapons testing, and the 241 Am formed in situ are concentrated in the sediments. A comparison of the total deposition of 239 , 240 Pu and 137 Cs indicates that 137 Cs may be valuable as a monitor for 239 , 240 Pu deposition in the sediments. Values of the 238 Pu/ 239 , 240 Pu ratio are in agreement with values reported in Lake Ontario sediments (and Lake Michigan plankton) and show little variation with depth. 241 Am data support the concept of in situ production with little preferential mobility after formation. Studies of sedimentary phase distributions show that 239 , 240 Pu is associated with hydrous oxide phases which are chemically stable under the prevailing conditions in lake sediments. Since Lake Michigan sediments remain aerobic, relatively little 239 , 240 Pu is available for chemical mobilization from the hydrous oxide or organic phases present in the sediments

  13. Synthetic musk fragrances in Lake Michigan.

    Science.gov (United States)

    Peck, Aaron M; Hornbuckle, Keri C

    2004-01-15

    Synthetic musk fragrances are added to a wide variety of personal care and household products and are present in treated wastewater effluent. Here we report for the first time ambient air and water measurements of six polycyclic musks (AHTN, HHCB, ATII, ADBI, AHMI, and DPMI) and two nitro musks (musk xylene and musk ketone) in North America. The compounds were measured in the air and water of Lake Michigan and in the air of urban Milwaukee, WI. All of the compounds except DPMI were detected. HHCB and AHTN were found in the highest concentrations in all samples. Airborne concentrations of HHCB and AHTN average 4.6 and 2.9 ng/m3, respectively, in Milwaukee and 1.1 and 0.49 ng/m3 over the lake. The average water concentration of HHCB and AHTN in Lake Michigan was 4.7 and 1.0 ng/L, respectively. A lake-wide annual mass budget shows that wastewater treatment plant discharge is the major source (3470 kg/yr) of the synthetic musks while atmospheric deposition contributes less than 1%. Volatilization and outflow through the Straits of Mackinac are major loss mechanisms (2085 and 516 kg/yr for volatilization and outflow, respectively). Concentrations of HHCB are about one-half the predicted steady-state water concentrations in Lake Michigan.

  14. Contrasting expression of membrane metalloproteinases, MT1-MMP and MT3-MMP, suggests distinct functions in skeletal development.

    Science.gov (United States)

    Yang, Maozhou; Zhang, Bingbing; Zhang, Liang; Gibson, Gary

    2008-07-01

    Membrane-type 1 matrix metalloproteinase (MT1-MMP) is the most ubiquitous and widely studied of the membrane-type metalloproteinases (MT-MMPs). It was thus surprising to find no published data on chicken MT1-MMP. We report here the characterization of the chicken gene. Its low sequence identity with the MT1-MMP genes of other species, high GC content, and divergent catalytic domain explains the absence of data and our difficulties in characterizing the gene. The absence of structural features in the chicken gene that have been suggested to be critical for the activation of MMP-2 by MT1-MMP; for the effect of MT1-MMP on cell migration and for the recycling of MT1-MMP suggest these features are either not essential or that MT1-MMP does not perform these functions in chickens. Comparison of the expression of chicken MT1-MMP with MT3-MMP and with MMP-2 and MMP-13 has confirmed the previously recognized co-expression of MT1-MMP with MMP-2 and MMP-13 in fibrous and vascular tissues, particularly those surrounding the developing long bones in other species. By contrast, MT3-MMP expression differs markedly from that of MT1-MMP and of both MMP-2 and MMP-13. MT3-MMP is expressed by chondrocytes of the developing articular surface. Similar expression patterns of this group of MT-MMPs and MMPs have been observed in mouse embryos and suggest distinct and specific functions for MT1-MMP and MT3-MMP in skeletal development.

  15. 76 FR 18040 - Amendment of Class E Airspace; West Yellowstone, MT

    Science.gov (United States)

    2011-04-01

    ... airspace at Yellowstone Airport, West Yellowstone, MT, to accommodate aircraft using Instrument Landing... the earth. * * * * * ANM MT E5 West Yellowstone, MT [Amended] West Yellowstone, Yellowstone Airport...

  16. Fast-Food Consumption and Obesity Among Michigan Adults

    OpenAIRE

    Anderson, Beth; Lyon-Callo, Sarah; Fussman, Christopher; Imes, Gwendoline; Rafferty, Ann P.

    2011-01-01

    Introduction Consumption of meals eaten away from home, especially from fast-food restaurants, has increased in the United States since the 1970s. The main objective of this study was to examine the frequency and characteristics of fast-food consumption among adults in Michigan and obesity prevalence. Methods We analyzed data from 12 questions about fast-food consumption that were included on the 2005 Michigan Behavioral Risk Factor Survey, a population-based telephone survey of Michigan adul...

  17. Positron Emission Tomography-Scanner at Children`s Hospital of Michigan at Detroit, Michigan

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    The Department of Energy has prepared an environmental assessment (EA), DOE/EA-0795, to support the DOE decision to provide a grant of $7,953,600 to be used in support of a proposed Positron Emission Tomography Scanner at Children`s Hospital of Michigan at Detroit, Michigan. Based upon the analysis in the EA, DOE has determined that the proposed action is not a major Federal action significantly affected the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 (NEPA). Therefore, the preparation of an Environmental Impact Statement is not required and DOE is issuing this Finding of No Significant Impact (FONSI).

  18. Positron Emission Tomography-Scanner at Children's Hospital of Michigan at Detroit, Michigan

    International Nuclear Information System (INIS)

    1992-01-01

    The Department of Energy has prepared an environmental assessment (EA), DOE/EA-0795, to support the DOE decision to provide a grant of $7,953,600 to be used in support of a proposed Positron Emission Tomography Scanner at Children's Hospital of Michigan at Detroit, Michigan. Based upon the analysis in the EA, DOE has determined that the proposed action is not a major Federal action significantly affected the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 (NEPA). Therefore, the preparation of an Environmental Impact Statement is not required and DOE is issuing this Finding of No Significant Impact (FONSI)

  19. Lake Michigan Offshore Wind Feasibility Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Boezaart, Arnold [GVSU; Edmonson, James [GVSU; Standridge, Charles [GVSU; Pervez, Nahid [GVSU; Desai, Neel [University of Michigan; Williams, Bruce [University of Delaware; Clark, Aaron [GVSU; Zeitler, David [GVSU; Kendall, Scott [GVSU; Biddanda, Bopi [GVSU; Steinman, Alan [GVSU; Klatt, Brian [Michigan State University; Gehring, J. L. [Michigan State University; Walter, K. [Michigan State University; Nordman, Erik E. [GVSU

    2014-06-30

    The purpose of this project was to conduct the first comprehensive offshore wind assessment over Lake Michigan and to advance the body of knowledge needed to support future commercial wind energy development on the Great Lakes. The project involved evaluation and selection of emerging wind measurement technology and the permitting, installation and operation of the first mid-lake wind assessment meteorological (MET) facilities in Michigan’s Great Lakes. In addition, the project provided the first opportunity to deploy and field test floating LIDAR and Laser Wind Sensor (LWS) technology, and important research related equipment key to the sitting and permitting of future offshore wind energy development in accordance with public participation guidelines established by the Michigan Great Lakes Wind Council (GLOW). The project created opportunities for public dialogue and community education about offshore wind resource management and continued the dialogue to foster Great Lake wind resource utilization consistent with the focus of the GLOW Council. The technology proved to be effective, affordable, mobile, and the methods of data measurement accurate. The public benefited from a substantial increase in knowledge of the wind resources over Lake Michigan and gained insights about the potential environmental impacts of offshore wind turbine placements in the future. The unique first ever hub height wind resource assessment using LWS technology over water and development of related research data along with the permitting, sitting, and deployment of the WindSentinel MET buoy has captured public attention and has helped to increase awareness of the potential of future offshore wind energy development on the Great Lakes. Specifically, this project supported the acquisition and operation of a WindSentinel (WS) MET wind assessment buoy, and associated research for 549 days over multiple years at three locations on Lake Michigan. Four research objectives were defined for the

  20. 76 FR 36152 - Notice of Inventory Completion: Western Michigan University, Anthropology Department, Kalamazoo...

    Science.gov (United States)

    2011-06-21

    ...: Western Michigan University, Anthropology Department, Kalamazoo, MI; Correction AGENCY: National Park... human remains and associated funerary objects. Western Michigan University, Department of Anthropology... may contact the Western Michigan University, Department of Anthropology. Disposition of the human...

  1. 76 FR 28077 - Notice of Inventory Completion: Western Michigan University, Anthropology Department, Kalamazoo, MI

    Science.gov (United States)

    2011-05-13

    ...: Western Michigan University, Anthropology Department, Kalamazoo, MI AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: Western Michigan University, Department of Anthropology, has completed... contact the Western Michigan University, Department of Anthropology. Disposition of the human remains to...

  2. 76 FR 36149 - Notice of Inventory Completion: Western Michigan University, Department of Anthropology...

    Science.gov (United States)

    2011-06-21

    ...: Western Michigan University, Department of Anthropology, Kalamazoo, MI AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: Western Michigan University, Department of Anthropology, has completed... contact the Western Michigan University, Department of Anthropology. Disposition of the human remains and...

  3. Mt. Kilimanjaro expedition in earth science education

    Science.gov (United States)

    Sparrow, Elena; Yoshikawa, Kenji; Narita, Kenji; Brettenny, Mark; Yule, Sheila; O'Toole, Michael; Brettenny, Rogeline

    2010-05-01

    Mt. Kilimanjaro, Africa's highest mountain is 5,895 meters above sea level and is located 330 km south of the equator in Tanzania. In 1976 glaciers covered most of Mt. Kilimanjaro's summit; however in 2000, an estimated eighty percent of the ice cap has disappeared since the last thorough survey done in 1912. There is increased scientific interest in Mt. Kilimanjaro with the increase in global and African average temperatures. A team of college and pre-college school students from Tanzania, South Africa and Kenya, teachers from South Africa and the United States, and scientists from the University of Alaska Fairbanks in the United States and Akita University in Japan, climbed to the summit of Mt Kilimanjaro in October 2009. They were accompanied by guides, porters, two expedition guests, and a videographer. This expedition was part of the GLOBE Seasons and Biomes Earth System Science Project and the GLOBE Africa science education initiative, exploring and contributing to climate change studies. Students learned about earth science experientially by observing their physical and biological surroundings, making soil and air temperature measurements, participating in discussions, journaling their experience, and posing research questions. The international trekkers noted the change in the biomes as the altitude, temperature and conditions changed, from cultivated lands, to rain forest, heath zone, moorland, alpine desert, and summit. They also discovered permafrost, but not at the summit as expected. Rather, it was where the mountain was not covered by a glacier and thus more exposed to low extreme temperatures. This was the first report of permafrost on Mt. Kilimanjaro. Classrooms from all over the world participated in the expedition virtually. They followed the trek through the expedition website (http://www.xpeditiononline.com/) where pictures and journals were posted, and posed their own questions which were answered by the expedition and base camp team members

  4. Comparative analysis of discharges into Lake Michigan, Phase I - Southern Lake Michigan.

    Energy Technology Data Exchange (ETDEWEB)

    Veil, J. A.; Elcock, D.; Gasper, J. R.; Environmental Science Division

    2008-06-30

    BP Products North America Inc. (BP) owns and operates a petroleum refinery located on approximately 1,700 acres in Whiting, East Chicago, and Hammond, Indiana, near the southern tip of Lake Michigan. BP provided funding to Purdue University-Calumet Water Institute (Purdue) and Argonne National Laboratory (Argonne) to conduct studies related to wastewater treatment and discharges. Purdue and Argonne are working jointly to identify and characterize technologies that BP could use to meet the previous discharge permit limits for total suspended solids (TSS) and ammonia after refinery modernization. In addition to the technology characterization work, Argonne conducted a separate project task, which is the subject of this report. In Phase I of a two-part study, Argonne estimated the current levels of discharge to southern Lake Michigan from significant point and nonpoint sources in Illinois, Indiana, and portions of Michigan. The study does not consider all of the chemicals that are discharged. Rather, it is narrowly focused on a selected group of pollutants, referred to as the 'target pollutants'. These include: TSS, ammonia, total and hexavalent chromium, mercury, vanadium, and selenium. In Phase II of the study, Argonne will expand the analysis to cover the entire Lake Michigan drainage basin.

  5. Project '80, Rural Michigan Now and in 1980; Michigan's Outdoor Recreation and Tourism.

    Science.gov (United States)

    Milstein, David N.

    Michigan is widely recognized as a traditional leader in outdoor recreation and tourism. Its location and resources provide many comparative advantages toward attracting visitors. State spending for outdoor recreation amounted to $95 million over the decade ending in 1960. State and Federal policies and programs are likely to emphasize outdoor…

  6. Evaporite karst of northern lower Michigan

    Science.gov (United States)

    Black, T.J.

    1997-01-01

    Michigan has three main zones of evaporite karst: collapse breccia in Late Silurian deposits of the Mackinac Straits region; breccia, collapse sinks, and mega-block collapse in Middle Devonian deposits of Northern Lower Michigan, which overlaps the preceding area; and areas of soil swallows in sinks of Mississippian deposits between Turner and Alabaster in Arenac and Iosco counties, and near Grand Rapids in Kent County. The author has focused his study on evaporite karst of the Middle Devonian deposits. The Middle Devonian depos its are the Detroit River Group: a series consisting of limestone, dolomite, shale, salt, gypsum, and anhydrite. The group occurs from subcrop, near the surface, to nearly 1400 feet deep from the northern tip of the Southern Peninsula to the south edge of the "solution front" Glacial drift is from zero to 350 feet thick. Oil and gas exploration has encountered some significant lost-circulation zones throughout the area. Drilling without fluid returns, casing-seal failures, and lost holes are strong risks in some parts of the region. Lost fluid returns near the top of the group in nearby areas indicate some karst development shortly after deposition. Large and irregular lost-circulation zones, linear and patch trends of large sink holes, and 0.25 mile wide blocks of down-dropped land in the northern Lower Peninsula of Michigan were caused by surface- and ground-water movement along faults into the Detroit River Group. Glaciation has removed some evidence of the karst area at the surface. Sinkhole development, collapse valleys, and swallows developed since retreat of the glacier reveal an active solution front in the Detroit River Group.

  7. Mortality Rates Among Arab Americans in Michigan

    OpenAIRE

    Dallo, Florence J.; Schwartz, Kendra; Ruterbusch, Julie J.; Booza, Jason; Williams, David R.

    2012-01-01

    The objectives of this study were to: (1) calculate age-specific and age-adjusted cause-specific mortality rates for Arab Americans; and (2) compare these rates with those for blacks and whites. Mortality rates were estimated using Michigan death certificate data, an Arab surname and first name list, and 2000 U.S. Census data. Age-specific rates, age-adjusted all-cause and cause-specific rates were calculated. Arab Americans (75+) had higher mortality rates than whites and blacks. Among men, ...

  8. Creating Safe and Healthy Futures: Michigan Youth Violence Prevention Center

    Science.gov (United States)

    Morrel-Samuels, Susan; Zimmerman, Marc A.; Reischl, Thomas M.

    2013-01-01

    Youth are in the cross-fire of gun violence, and the highest rate in the nation is in Flint, Michigan. This article highlights six innovative strategies that prepare youth to solve problems at home and in their communities in peaceful ways. The Michigan Youth Violence Prevention Center (MI-YVPC) works with community groups to strengthen…

  9. Education Inputs, Student Performance and School Finance Reform in Michigan

    Science.gov (United States)

    Chaudhary, Latika

    2009-01-01

    This paper estimates the impact of the Michigan school finance reform, "Proposal A," on education inputs and test scores. Using a difference-in-difference estimation strategy, I find that school districts in Michigan used the increase in educational spending generated through "Proposal A" to increase teacher salaries and reduce…

  10. Lake Michigan lake trout PCB model forecast post audit

    Science.gov (United States)

    Scenario forecasts for total PCBs in Lake Michigan (LM) lake trout were conducted using the linked LM2-Toxics and LM Food Chain models, supported by a suite of additional LM models. Efforts were conducted under the Lake Michigan Mass Balance Study and the post audit represents th...

  11. Estimating Cause: Teacher Turnover and School Effectiveness in Michigan

    Science.gov (United States)

    Keesler, Venessa; Schneider, Barbara

    2010-01-01

    The purpose of this paper is investigate issues related to within-school teacher supply and school-specific teacher turnover within the state of Michigan using state administrative data on Michigan's teaching force. This paper 1) investigates the key predictors of teacher turnover and mobility, 2) develops a profile of schools that are likely to…

  12. Unemployment Insurance Fund Insolvency and Debt in Michigan.

    Science.gov (United States)

    Blaustein, Saul J.

    Without changes in Michigan's unemployment insurance law, the state's unemployment insurance debt will probably reach $3.8 billion by the end of 1985. Currently, Michigan's employers pay unemployment insurance tax rates that vary from 1 to 9 percent, depending upon the amount of benefits charged against their accounts. Beginning with the federal…

  13. Periodic disruptions in the MT-1 tokamak

    International Nuclear Information System (INIS)

    Zoletnik, S.

    1988-11-01

    Disruptive instabilities are common phenomena in toroidal devices, especially in tokamaks. Three types can be distinguished: internal, minor and major disruptions. Periodic minor disruptions in the MT-1 tokamak were measured systematically with values of the limiter safety factor between 4 and 10. The density limit as a function of plasma current and horizontal displacement was investigated. Precursor oscillations always appear before the instability with increasing amplitude but can be observed at the density limit with quasi-stationary amplitude. Phase correlation between precursor oscillations were measured with Mirnov coils and x-ray detectors, and they show good agreement with a simple magnetic island model. (R.P.) 11 refs.; 6 figs

  14. Agreement Between Michigan State University and Lodge 141, Fraternal Order of Police, Michigan State University Division, July 1, 1974.

    Science.gov (United States)

    Michigan State Univ., East Lansing.

    This agreement, entered into July 1, 1974, is between the Board of Trustees of Michigan State University and Lodge 141 of the Fraternal Order of Police, Michigan State University Division. It is the intent and purpose of this agreement to assure sound and mutually beneficial working and economic relationships between the parties, to provide an…

  15. Recruitment variability of alewives in Lake Michigan

    Science.gov (United States)

    Madenjian, C.P.; Hook, T.O.; Rutherford, E.S.; Mason, D.M.; Croley, T.E.; Szalai, E.B.; Bence, J.R.

    2005-01-01

    We used a long-term series of observations on alewife Alosa pseudoharengus abundance that was based on fall bottom-trawl catches to assess the importance of various abiotic and biotic factors on alewife recruitment in Lake Michigan during 1962–2002. We first fit a basic Ricker spawner–recruit model to the lakewide biomass estimates of age-3 recruits and the corresponding spawning stock size; we then fit models for all possible combinations of the following four external variables added to the basic model: an index of salmonine predation on an alewife year-class, an index for the spring–summer water temperatures experienced by alewives during their first year in the lake, an index of the severity of the first winter experienced by alewives in the lake, and an index of lake productivity during an alewife year-class's second year in the lake. Based on an information criterion, the best model for alewife recruitment included indices of salmonine predation and spring–summer water temperatures as external variables. Our analysis corroborated the contention that a decline in alewife abundance during the 1970s and early 1980s in Lake Michigan was driven by salmonine predation. Furthermore, our findings indicated that the extraordinarily warm water temperatures during the spring and summer of 1998 probably led to a moderately high recruitment of age-3 alewives in 2001, despite abundant salmonines.

  16. New Radioligands for Describing the Molecular Pharmacology of MT1 and MT2 Melatonin Receptors

    Directory of Open Access Journals (Sweden)

    Olivier Nosjean

    2013-04-01

    Full Text Available Melatonin receptors have been studied for several decades. The low expression of the receptors in tissues led the scientific community to find a substitute for the natural hormone melatonin, the agonist 2-[125I]-iodomelatonin. Using the agonist, several hundreds of studies were conducted, including the discovery of agonists and antagonists for the receptors and minute details about their molecular behavior. Recently, we attempted to expand the panel of radioligands available for studying the melatonin receptors by using the newly discovered compounds SD6, DIV880, and S70254. These compounds were characterized for their affinities to the hMT1 and hMT2 recombinant receptors and their functionality in the classical GTPS system. SD6 is a full agonist, equilibrated between the receptor isoforms, whereas S70254 and DIV880 are only partial MT2 agonists, with Ki in the low nanomolar range while they have no affinity to MT1 receptors. These new tools will hopefully allow for additions to the current body of information on the native localization of the receptor isoforms in tissues.

  17. The seismic monitoring network of Mt. Vesuvius

    Directory of Open Access Journals (Sweden)

    Massimo Orazi

    2013-11-01

    Full Text Available Mt. Vesuvius (southern Italy is one of the most hazardous volcanoes in the world. Its activity is currently characterized by moderate seismicity, with hypocenters located beneath the crater zone with depth rarely exceeding 5 km and magnitudes generally less than 3. The current configuration of the seismic monitoring network of Mt. Vesuvius consists of 18 seismic stations and 7 infrasound microphones. During the period 2006-2010 a seismic array with 48 channels was also operative. The station distribution provides appropriate coverage of the area around the volcanic edifice. The current development of the network and its geometry, under conditions of low seismic noise, allows locating seismic events with M<1. Remote instruments continuously transmit data to the main acquisition center in Naples. Data transmission is realized using different technological solutions based on UHF, Wi-Fi radio links, and TCP/IP client-server applications. Data are collected in the monitoring center of the Osservatorio Vesuviano (Italian National Institute of Geophysics and Volcanology, Naples section, which is equipped with systems for displaying and analyzing signals, using both real-time automatic and manual procedures. 24-hour surveillance allows to immediately communicate any significant anomaly to the Civil Protection authorities.

  18. Keeping mtDNA in shape between generations.

    Directory of Open Access Journals (Sweden)

    James B Stewart

    2014-10-01

    Full Text Available Since the unexpected discovery that mitochondria contain their own distinct DNA molecules, studies of the mitochondrial DNA (mtDNA have yielded many surprises. In animals, transmission of the mtDNA genome is explicitly non-Mendelian, with a very high number of genome copies being inherited from the mother after a drastic bottleneck. Recent work has begun to uncover the molecular details of this unusual mode of transmission. Many surprising variations in animal mitochondrial biology are known; however, a series of recent studies have identified a core of evolutionarily conserved mechanisms relating to mtDNA inheritance, e.g., mtDNA bottlenecks during germ cell development, selection against specific mtDNA mutation types during maternal transmission, and targeted destruction of sperm mitochondria. In this review, we outline recent literature on the transmission of mtDNA in animals and highlight the implications for human health and ageing.

  19. Environmental status of the Lake Michigan region. Volume 6. Zoobenthos of Lake Michigan

    Energy Technology Data Exchange (ETDEWEB)

    Mozley, S.C.; Howmiller, R.P.

    1977-09-01

    This report summarizes Lake Michigan zoobenthic studies up to 1974, including reports of power-plant surveys. It describes ecologies of macroinvertebrate species and some microfauna, partly through use of data from other Great Lakes. The following are discussed: methodology of field surveys; zoobenthic indicators of pollution; zoobenthic effects on sediment-water exchanges; and numbers, biomass, and production of total macroinvertebrates. Prominent features of Lake Michigan zoobenthos include predominance of the amphipod Pontoporeia affinis, usefulness of tubificid oligochaetes in mapping environmental quality, and pronounced qualitative gradients in zoobenthos in relation to depth. Further research is needed on sampling methods, energy flow rates and pathways through benthic communities, factors limiting distribution of species near shore, and effects of macroinvertebrates on sediment chemistry and structure.

  20. Overexposure measurement on microtron MT-17

    International Nuclear Information System (INIS)

    Dang Thanh Luong; Tran Thanh Minh

    1995-01-01

    On 11 November 1992, the Radiation accident happened at the channel of the high energy photon beam generated by stopping 15 MeV accelerated electron on the tungsten target of Microtron MT-17. One physicist has been exposed to the high energy photon beam. The purposes of this work are the determination of overexposure from backscatter and primary beams to estimate the whole body and hand doses received by the victim. It was found that the upper parts of his body may be received the dose from 1.0 Gy to 5.0 Gy per 4 min. of the exposure; the dose received by victim's hands is in interval of 30 - 50 Gy. (author). 3 refs., 5 figs., 5 tabs

  1. Visual Virtual MT: relato de una pesquisa

    Directory of Open Access Journals (Sweden)

    LUDMILA BRANDÃO

    2015-01-01

    Full Text Available Con el fin de contribuir a la discusión acerca de las artes visuales en la sociedad contemporánea y de los dispositivos que operan la colonialidad del arte, sus mecanismos y efectos, cuya urgente desactivación nos impone enormes retos, en este artículo se presentan los resultados de la investigación titulada: “Artes Visuales en Mato Grosso: recopilación, difusión y crítica” encargada de crear el sitio Visual Virtual MT (VVMT. El VVMT reúne producciones aestésicas visuales de artistas individuales y colectivos que operan en diferentes soportes y medios, trabajando con una variedad de materiales que configuran, actualmente, la mayor colección catalogada y digital disponible en el Estado de Mato Grosso, en Brasil.

  2. Preliminary geothermal study of Mt. Etna

    Energy Technology Data Exchange (ETDEWEB)

    Mongelli, F; Morelli, C

    1964-01-01

    The geothermal status of Italy's Mt. Etna region was studied via borehole thermometry at eight experimental sites. The mathematical principles and other criteria used in borehole site and well depth selection are discussed. The soil temperature is regulated by external temperature variations to a certain depth. The minimum drilling distance which would provide accurate temperature determinations was calculated to be 30 m. The geothermal gradient was determined by the application of a Fourier series to three measurements made at different depths using resistance thermometers. The results are presented in tables and the gradients are plotted on graphs. Geothermal gradient determinations were corrected for topographic effects. Two major groups of gradients were discovered, those having linear gradients were interpreted as being due to the effect of meteoric waters. Other possible disturbances are those caused by surface temperature effects and the influence of nearby bodies of water.

  3. Sarcoptic mange in raccoons in Michigan.

    Science.gov (United States)

    Fitzgerald, Scott D; Cooley, Thomas M; Murphy, Alice; Cosgrove, Melinda K; King, Betty A

    2004-04-01

    Sarcoptic mange is a cause of pruritic skin disease in domestic dogs and a wide range of wildlife species. We describe sarcoptic mange in free-ranging raccoons (Procyon lotor). Three adult raccoons from upper Wayne County, Michigan (USA), were captured, killed, and submitted for diagnostic evaluation. The animals were intensely pruritic, and two had advanced alopecic and crusting lesions over their dorsum and hind limbs. Skin scrapings and skin biopsies revealed crusting and hyperkeratotic dermatitis with high numbers of Sarcoptes scabiei adults, larvae, nymphs, and eggs. These raccoons were not otherwise debilitated, with minimal internal parasites, good body condition, and no evidence of infectious bacterial or viral diseases. Because sarcoptic mange is highly contagious and affects many species, including humans, transiently, it is important that wildlife biologists and rehabilitators include sarcoptic mange in their differential list for raccoons exhibiting pruritus and alopecia.

  4. Thermal discharge residence by Lake Michigan Salmonids

    International Nuclear Information System (INIS)

    Romberg, G.P.; Prepejchal, W.

    1975-01-01

    Lake Michigan salmon and trout were tagged with a thermoluminescent dosimeter (TLD) temperature tag to estimate their thermal exposure and residence time at a warm water discharge. Fish were collected, tagged, and released at the Point Beach Nuclear Plant, Two Rivers, Wisconsin, in the fall of 1973 and 1974. Tags were recovered during the same season, primarily from fish recaptured at Point Beach. Average uniform temperature exposure and maximum possible discharge residence time were determined. Appropriate hourly intake and discharge temperatures were averaged to calculate mean temperature exposure for the case of maximum discharge residence. Lowest discharge temperature not included within the period of maximum residence was identified to serve as a possible indicator of avoidance temperature. Mean values for the above parameters were calculated for fish species for each tagging year and are reported with the accompanying range of intake and discharge temperatures

  5. Surficial geologic map of Berrien County, Michigan, and the adjacent offshore area of Lake Michigan

    Science.gov (United States)

    Stone, Byron D.; Kincare, Kevin A.; O'Leary, Dennis W.; Newell, Wayne L.; Taylor, Emily M.; Williams, Van S.; Lundstrom, Scott C.; Abraham, Jared E.; Powers, Michael H.

    2017-12-13

    The surficial geologic map of Berrien County, southwestern Michigan (sheet 1), shows the distribution of glacial and postglacial deposits at the land surface and in the adjacent offshore area of Lake Michigan. The geologic map differentiates surficial materials of Quaternary age on the basis of their lithologic characteristics, stratigraphic relationships, and age. Drill-hole information correlated in cross sections provides details of typical stratigraphic sequences that compose one or more penetrated geologic map units. A new bedrock geologic map (on sheet 2) includes contours of the altitude of the eroded top of bedrock and shows the distribution of middle Paleozoic shale and carbonate units in the subcrop. A sediment thickness map (also on sheet 2) portrays the extent of as much as 150 meters of surficial materials that overlie the bedrock surface.The major physical features of the county are related principally to deposits of the last Laurentide ice sheet that advanced and then retreated back through the region from about 19,000 to 14,000 radiocarbon years before present. Glacial and postglacial deposits underlie the entire county; shale bedrock crops out only in the adjacent offshore area on the bottom of Lake Michigan. All glacial deposits and glacial meltwater deposits in Berrien County are related to the late Wisconsinan glacial advances of the Lake Michigan ice lobe and its three regional recessional moraines, which cross the county as three north-northeast-trending belts.From east to west (oldest to youngest), the three moraine belts are known as the Kalamazoo, Valparaiso, and Lake Border morainic systems. The till-ridge morainic systems (Lake Border and local Valparaiso morainic systems) consist of multiple, elongate moraine ridges separated by till plains and lake-bottom plains. Tills in ground and end moraines in Berrien County are distinguished as informal units, and are correlated with three proposed regional till units in southwestern Michigan

  6. Magnetotelluric (MT) surveying in the Kakkonda geothermal area; Kakkonda chinetsu chiiki deno MT ho tansa jikken

    Energy Technology Data Exchange (ETDEWEB)

    Ogawa, Y; Takakura, S [Geological Survey of Japan, Tsukuba (Japan); Uchida, T [New Energy and Industrial Technology Development Organization, Tokyo, (Japan)

    1997-05-27

    This paper describes the MT surveying conducted at the vicinity of a deep well (WD-1) in the Kakkonda geothermal area. For the MT surveying, the interval between measuring points was 300 m. Electric field dipole with a length of 300 m was given in the direction of traverse line, and that with a length of 50 m was given in the direction perpendicular to the line. Three components of magnetic field were measured using induction coil. Frequency band of the data was between 0.0005 Hz and 300 Hz. Characteristics of specific resistance model obtained from the MT surveying were illustrated. Low specific resistance zone less than 30 ohm-m was observed in the shallow zone below the altitude 0 m. This zone was comparable to the distribution of montmorillonite. High specific resistance anomaly was analyzed at the western half of the traverse line in the altitude between 0 m and -2000 m, which corresponded to the collective part of focuses. The bottom surface of the anomaly agreed well with the upper surface of neo-granite, i.e., the lower limits of earthquakes. Low specific resistance was observed in the altitude below -2000 m. 17 refs., 5 figs.

  7. Construct Validity of the MMPI-2 College Maladjustment (Mt) Scale

    Science.gov (United States)

    Barthlow, Deanna L.; Graham, John R.; Ben-Porath, Yossef S.; McNulty, John L

    2004-01-01

    The construct validity of the MMPI-2 (Minnesota Multiphasic Personality Inventory-2) College Maladjustment (Mt) Scale was examined using 376 student clients at a university psychological clinic. A principal components analysis and correlations of Mt scale scores with clients' and therapists' ratings of symptoms and functioning showed that the Mt…

  8. Lake Michigan Fish Acoustic Data from 2011 to 2016

    Data.gov (United States)

    Department of the Interior — Each line in the file “Lake Michigan fish acoustic data from 2011 to 2016.csv” represents the acoustic data and estimated fish density for a single depth layer of...

  9. Michigan 2008 Lidar Coverage, USACE National Coastal Mapping Program

    Data.gov (United States)

    Army Corps of Engineers, Department of the Army, Department of Defense — The Joint Airborne Lidar Bathymetry Technical Center of Expertise (JALBTCX) has performed a coastal survey along the MI coasts of Lake Superior, Lake Michigan and...

  10. Pavement subgrade MR design values for Michigan's seasonal changes : appendices.

    Science.gov (United States)

    2009-07-22

    The resilient modulus (MR) of roadbed soil plays an integral role in the design of pavement systems. Currently, the various regions of the Michigan Department of Transportation (MDOT) use different procedures to determine the MR values. Most of these...

  11. Lake-wide distribution of Dreissena in Lake Michigan, 1999

    Science.gov (United States)

    Fleischer, Guy W.; DeSorcie, Timothy J.; Holuszko, Jeffrey D.

    2001-01-01

    The Great Lakes Science Center has conducted lake-wide bottom trawl surveys of the fish community in Lake Michigan each fall since 1973. These systematic surveys are performed at depths of 9 to 110 m at each of seven index sites around Lake Michigan. Zebra mussel (Dreissena polymorpha) populations have expanded to all survey locations and at a level to sufficiently contribute to the bottom trawl catches. The quagga (Dreissena bugensis), recently reported in Lake Michigan, was likely in the catches though not recognized. Dreissena spp. biomass ranged from about 0.6 to 15 kg/ha at the various sites in 1999. Dreissenid mussels were found at depths of 9 to 82 m, with their peak biomass at 27 to 46 m. The colonization of these exotic mussels has ecological implications as well as potential ramifications on the ability to sample fish consistently and effectively with bottom trawls in Lake Michigan.

  12. Willow Run Laboratories: Separating from the University of Michigan

    Science.gov (United States)

    Walsh, John

    1972-01-01

    Outlines the reasons for, and the problems involved in, separation of a research center from the University of Michigan in order to become an independent research organization contracting for private and military research. (AL)

  13. Prostate Cancer Clinical Trials Group: The University of Michigan Site

    Science.gov (United States)

    2011-04-01

    2931 alhawary@umich.edu Stephanie Daignault, MS, Biostatistician, Biostatistics Core University of Michigan Comprehensive Cancer Center NI8D11...Consortium; The Cancer Institute of New Jersey/University of Medicine and Dentistry of New Jersey, New Brunswick, NJ; Robert Wood Johnson Medical School...University of Medicine and Dentistry of New Jersey, New Brunswick, NJ; University of Michigan, Ann Arbor, MI; University of Wisconsin Carbone

  14. Cardiac surgeons and the quality movement: the Michigan experience.

    Science.gov (United States)

    Prager, Richard L; Armenti, Frederick R; Bassett, Joseph S; Bell, Gail F; Drake, Daniel; Hanson, Eric C; Heiser, John C; Johnson, Scott H; Plasman, F B; Shannon, Francis L; Share, David; Theurer, Patty; Williams, Jaelene

    2009-01-01

    The Michigan Society of Thoracic and Cardiovascular Surgeons created a voluntary quality collaborative with all the cardiac surgeons in the state and all hospitals doing adult cardiac surgery. Utilizing this collaborative over the last 3 years and creating a unique relationship with a payor, an approach to processes and outcomes has produced improvements in the quality of care for cardiac patients in the state of Michigan.

  15. 75 FR 43556 - TA-W-73,381, MT Rail Link, Inc., Missoula, MT; TA-W-73,381A, Billings, MT; TA-W-73,381B, Laurel...

    Science.gov (United States)

    2010-07-26

    ... DEPARTMENT OF LABOR Employment and Training Administration TA-W-73,381, MT Rail Link, Inc., Missoula, MT; TA-W-73,381A, Billings, MT; TA-W-73,381B, Laurel, MT; TA-W-73,381C, Livingston, MT; TA-W-73... Helena, Montana. The amended notice applicable to TA-W-73,381 is hereby issued as follows: All workers of...

  16. MT3DMS: Model use, calibration, and validation

    Science.gov (United States)

    Zheng, C.; Hill, Mary C.; Cao, G.; Ma, R.

    2012-01-01

    MT3DMS is a three-dimensional multi-species solute transport model for solving advection, dispersion, and chemical reactions of contaminants in saturated groundwater flow systems. MT3DMS interfaces directly with the U.S. Geological Survey finite-difference groundwater flow model MODFLOW for the flow solution and supports the hydrologic and discretization features of MODFLOW. MT3DMS contains multiple transport solution techniques in one code, which can often be important, including in model calibration. Since its first release in 1990 as MT3D for single-species mass transport modeling, MT3DMS has been widely used in research projects and practical field applications. This article provides a brief introduction to MT3DMS and presents recommendations about calibration and validation procedures for field applications of MT3DMS. The examples presented suggest the need to consider alternative processes as models are calibrated and suggest opportunities and difficulties associated with using groundwater age in transport model calibration.

  17. Mortality rates among Arab Americans in Michigan.

    Science.gov (United States)

    Dallo, Florence J; Schwartz, Kendra; Ruterbusch, Julie J; Booza, Jason; Williams, David R

    2012-04-01

    The objectives of this study were to: (1) calculate age-specific and age-adjusted cause-specific mortality rates for Arab Americans; and (2) compare these rates with those for blacks and whites. Mortality rates were estimated using Michigan death certificate data, an Arab surname and first name list, and 2000 U.S. Census data. Age-specific rates, age-adjusted all-cause and cause-specific rates were calculated. Arab Americans (75+) had higher mortality rates than whites and blacks. Among men, all-cause and cause-specific mortality rates for Arab Americans were in the range of whites and blacks. However, Arab American men had lower mortality rates from cancer and chronic lower respiratory disease compared to both whites and blacks. Among women, Arab Americans had lower mortality rates from heart disease, cancer, stroke, and diabetes than whites and blacks. Arab Americans are growing in number. Future study should focus on designing rigorous separate analyses for this population.

  18. Viscosity controlled magma-carbonate interaction: a comparison of Mt. Vesuvius (Italy) and Mt. Merapi (Indonesia).

    Science.gov (United States)

    Blythe, L. S.; Misiti, V.; Masotta, M.; Taddeucci, J.; Freda, C.; Troll, V. R.; Deegan, F. M.; Jolis, E. M.

    2012-04-01

    Magma-carbonate interaction is increasingly seen as a viable and extremely important cause of magma contamination, and the generation of a crustally sourced CO2 phase (Goff et al., 2001; Freda et al., 2010). Even though the process is well recognized at certain volcanoes e.g. Popocatépetl, (Mexico); Merapi, (Indonesia); and Colli Albani, (Italy) (Goff et al., 2001; Deegan et al., 2010; Freda et al., 2010), neither the kinetics of carbonate assimilation nor its consequences for controlling the explosivity of eruptions have been constrained. Here we show the results of magma-carbonate interaction experiments conducted at 1200 °C and 0.5 GPa for varying durations (0 s, 60 s, 90 s and 300 s) for the Mt. Merapi (Indonesia) and Mt. Vesuvius (Italy) volcanic systems. We performed experiments using glassy starting materials specific to each volcano (shoshonite for Mt. Vesuvius, basaltic-andesite for Mt. Merapi) with different degrees of hydration (anhydrous vs hydration with ~ 2 wt % water) and using carbonate fragments of local origin; see Deegan et al., (2010) and Jolis et al., (2011). Experimental products include a gas phase (CO2-rich) and two melt phases, one pristine (Ca-normal) and one contaminated (Ca-rich) separated by a 'contamination front' which propagates outwards from the carbonate clast. Vesicles appear to nucleate in the contaminated glass and then migrate into the pristine one. Both contamination front propagation and bubble migration away from the carbonate are slower in anhydrous basaltic-andesite (Merapi anhydrous series) than in hydrated basaltic-andesite and shoshonite (Merapi and Vesuvius hydrated series), suggesting that assimilation speed is strongly controlled by the degree of hydration and the SiO2 content, both of which influence melt viscosity and hence diffusivity. As the carbonate dissolution proceeds in our experiments, initially dissolved and eventually exsolved CO2 builds up in the contaminated Ca-rich melt phase. Once melt volatile

  19. Environmental status of the Lake Michigan region. Volume 3. Chemistry of Lake Michigan

    Energy Technology Data Exchange (ETDEWEB)

    Torrey, M S

    1976-05-01

    The report is a synoptic review of data collected over the past twenty years on the chemistry of Lake Michigan. Changes in water quality and sediment chemistry, attributable to cultural and natural influences, are considered in relation to interacting processes and factors controlling the distribution and concentration of chemical substances within the Lake. Temperature, light, and mixing processes are among the important natural influences that affect nutrient cycling, dispersal of pollutants, and fate of materials entering the Lake. Characterization of inshore-offshore and longitudinal differences in chemical concentrations and sediment chemistry for the main body of the Lake is supplemented by discussion of specific areas such as Green Bay and Grand Traverse Bay. Residues, specific conductance, dissolved oxygen, major and trace nutrients, and contaminants are described in the following context: biological essentiality and/or toxicity, sources to the Lake, concentrations in the water column and sediments, chemical forms, seasonal variations and variation with depth. A summary of existing water quality standards, statutes, and criteria applicable to Lake Michigan is appended.

  20. Environmental status of the Lake Michigan region. Volume 14. Birds of the Lake Michigan drainage basin

    Energy Technology Data Exchange (ETDEWEB)

    Wallace, G.J.

    1977-07-01

    This report characterizes the bird life found in 100 counties of the four states peripheral to Lake Michigan. It discusses major habitats (the Lake Michigan shoreline, inland lakes, rivers and streams, marshes, fields and open spaces, and woodlots) and associates specific birds with habitats according to preferences for space and food. It also discusses the special attributes of state parks and lakeshores, refuges and sanctuaries, and other special areas which are attractive to avifauna. Patterns of historical occurrence and abundance, and the influence of pesticides and pollution, disease, and hunting pressure are explored to place present occurrence in a modern perspective. Migration patterns are discussed to explain increases and decreases which occur in nonresident avifauna of the Basin. The distribution and habits of birds that occur regularly in the Basin are described in an annotated list; a more complete list is presented in a table which encapsulates data for rapid and convenient reference. Separate sections deal with extinct, extirpated, and introduced species, and with endangered, threatened, and declining species.

  1. Porous aerosol in degassing plumes of Mt. Etna and Mt. Stromboli

    Directory of Open Access Journals (Sweden)

    V. Shcherbakov

    2016-09-01

    Full Text Available Aerosols of the volcanic degassing plumes from Mt. Etna and Mt. Stromboli were probed with in situ instruments on board the Deutsches Zentrum für Luft- und Raumfahrt research aircraft Falcon during the contrail, volcano, and cirrus experiment CONCERT in September 2011. Aerosol properties were analyzed using angular-scattering intensities and particle size distributions measured simultaneously with the Polar Nephelometer and the Forward Scattering Spectrometer probes (FSSP series 100 and 300, respectively. Aerosols of degassing plumes are characterized by low values of the asymmetry parameter (between 0.6 and 0.75; the effective diameter was within the range of 1.5–2.8 µm and the maximal diameter was lower than 20 µm. A principal component analysis applied to the Polar Nephelometer data indicates that scattering features of volcanic aerosols of different crater origins are clearly distinctive from angular-scattering intensities of cirrus and contrails. Retrievals of aerosol properties revealed that the particles were "optically spherical" and the estimated values of the real part of the refractive index are within the interval from 1.35 to 1.38. The interpretation of these results leads to the conclusion that the degassing plume aerosols were porous with air voids. Our estimates suggest that aerosol particles contained about 18 to 35 % of air voids in terms of the total volume.

  2. Two-dimensional inversion of MT (magnetotelluric) data; MT ho no nijigen inversion kaiseki

    Energy Technology Data Exchange (ETDEWEB)

    Ito, S; Okuno, M; Ushijima, K; Mizunaga, H [Kyushu University, Fukuoka (Japan). Faculty of Engineering

    1997-05-27

    A program has been developed to conduct inversion analysis of two-dimensional model using MT data, accurately. For the developed program, finite element method (FEM) was applied to the section of sequential analysis. A method in which Jacobian matrix is calculated only one first time and is inversely analyzed by fixing this during the repetition, and a method in which Jacobian matrix is corrected at each repetition of inversion analysis, were compared mutually. As a result of the numerical simulation, it was revealed that the Jacobian correction method provided more stable convergence for the simple 2D model, and that the calculation time is almost same as that of the Jacobian fixation method. To confirm the applicability of this program to actually measured data, results obtained from this program were compared with those from the Schlumberger method analysis by using MT data obtained in the Hatchobara geothermal area. Consequently, it was demonstrated that the both are well coincided mutually. 17 refs., 7 figs.

  3. 76 FR 35967 - Amendment of Class E Airspace; Bozeman, MT

    Science.gov (United States)

    2011-06-21

    ..., Gallatin Field Airport, Bozeman, MT, to accommodate aircraft using Instrument Landing System (ILS... 6005 Class E airspace areas extending upward from 700 feet or more above the surface of the earth...

  4. MT Lajpatrai blow-out studies at Bombay harbour

    Digital Repository Service at National Institute of Oceanography (India)

    Fondekar, S.P.

    The area around the tanker MT Lajpatrai was monitored for oil pollution studies. Measurements were carried out on the concentration of petroleum hydrocarbons in water and sediment samples along with visual observations on oil slicks...

  5. [MT-45--a dangerous and potentially ototoxic internet drug].

    Science.gov (United States)

    Lindeman, Erik; Bäckberg, Matilda; Personne, Mark; Helander, Anders

    2014-09-11

    During the last years several synthetic opioids have been introduced on Internet sites selling new psychoactive substances (NPS). One of these, called MT-45, a piperazine derivative originally synthesized as a therapeutic drug candidate in the 1970s, has recently been detected in 21 deaths, according to unpublished data from the Swedish National Board of Forensic Medicine. We present clinical data from 12 analytically confirmed hospital cases of MT-45 poisoning. The cases demonstrate that MT-45, like other opioids, can induce potentially life threatening respiratory depression and loss of consciousness in users and that symptoms are usually reversed by standard doses of the opioid receptor antagonist naloxone. Significant auditory symptoms with transient tinnitus and hearing loss occurred in two cases and a pronounced sensorineural hearing loss still present at two weeks follow-up in one case. This indicates that MT-45 may be an ototoxic substance, illustrating the ubiquitous risk of unintended adverse effects NPSs pose to users.

  6. MICHIGAN/INDIANA: Siberian Snakes strike again

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    Full text: Siberian snakes are showing themselves to be even more deadly than expected in killing their prey, the depolarizing resonances which would make it very difficult to accelerate polarized protons to TeV energies at accelerators such as the Tevatron, UNK, LHC, and SSC. The snake concept was proposed in the mid-1970s by Siberians Yaroslav Derbenev and Anatoly Kondratenko at Novosibirsk, but the snakes lay almost dormant until Owen Chamberlain, Ernest Courant, Alan Krisch, and the late Kent Terwilliger organized the 1985 Superconducting Supercollider (SSC) polarized beam workshop in Ann Arbor, which highlighted the need to test the concept. The idea is to rotate the spin through 180° on each turn in the ring. With such successive spin flips, the depolarizing effects seen in one turn should be cancelled by an equal and opposite perturbation on the subsequent turn. The new Cooler Ring at the Indiana University Cyclotron Facility then seemed an excellent test site for these eager but untested serpents. The Michigan/lndiana/Brookhaven team led by Krisch constructed the world's first snake and found that it could easily overcome its initial enemy, the imperfection depolarizing resonances caused by ring magnet imperfections (January/February 1990, page 20). In the next few years the growing team of ''herpetologists'' showed that Siberian snakes could overcome all kinds of depolarizing resonances, including the intrinsic kind (caused by the vertical betatron oscillations which keep the beam focused) and the synchrotron resonances (caused by synchrotron oscillations in energy). The team also discovered a new type of snake that was inadvertently built into the cooling section. This socalled type-3 snake rotates the spin around the vertical direction. A full type-1 snake (such as the team's superconducting solenoid magnet) rotates the spin by 180° around the beam direction; a type-2 snake rotates the spin around the radial direction

  7. Flood of April 1975 at Williamston, Michigan

    Science.gov (United States)

    Knutilla, R.L.; Swallow, L.A.

    1975-01-01

    On April 18 between 5 p.m. and 12 p.m. the city of Williamston experienced an intense rain storm that caused the Red Cedar River and the many small streams in the area to overflow their banks and resulted in the most devastating flood since at least 1904. Local officials estimated a loss of \\$775,000 in property damage. Damage from flooding by the Red Cedar River was caused primarily by inundation, rather than by water moving at high velocity, as is common when many streams are flooded. During the flood of April 1975 many basements were flooded as well as the lower floors of some homes in the flood plain. Additional damage occurred in places when sewers backed up and flooded basements, and when ground water seeped through basement walls and floors—situations that affected many homes including those that were well outside of the flood plain.During the time of flooding the U.S. Geological Survey obtained aerial photography and data on a streamflow to document the disaster. This report shows on a photomosaic base map the extent of flooding along the Red Cedar River at Williamston, during the flood. It also presents data obtained at stream-gaging stations near Williamston, as well as the results of peak-flow discharge measurements made on the Red Cedar River at Michigan State Highway M-52 east of the city. Information on the magnitude of the flood can guide in making decisions pertaining to the use of flood-plains in the area. It is one of a series of reports on the April 1975 flood in the Lansing metropolitan area.

  8. 76 FR 36145 - Notice of Inventory Completion: Western Michigan University, Department of Anthropology...

    Science.gov (United States)

    2011-06-21

    ...: Western Michigan University, Department of Anthropology, Kalamazoo, MI AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: Western Michigan University, Department of Anthropology, has completed..., Department of Anthropology. Disposition of the human remains and associated funerary objects to the Indian...

  9. 75 FR 67998 - Notice of Inventory Completion: Western Michigan University, Anthropology Department, Kalamazoo, MI

    Science.gov (United States)

    2010-11-04

    ... University, Anthropology Department, Kalamazoo, MI AGENCY: National Park Service, Interior. ACTION: Notice... objects in the possession of Western Michigan University, Anthropology Department, Kalamazoo, MI. The... anthropologist in the Anthropology Department at Western Michigan University, studied the remains. Native...

  10. 75 FR 5105 - Notice of Inventory Completion: Western Michigan University, Anthropology Department, Kalamazoo, MI

    Science.gov (United States)

    2010-02-01

    ... University, Anthropology Department, Kalamazoo, MI AGENCY: National Park Service, Interior. ACTION: Notice... objects in the possession of Western Michigan University, Anthropology Department, Kalamazoo, MI. The... analysis. Dr. Robert Sundick, a physical anthropologist in the Anthropology Department at Western Michigan...

  11. 76 FR 28078 - Notice of Inventory Completion: Western Michigan University, Anthropology Department, Kalamazoo, MI

    Science.gov (United States)

    2011-05-13

    ...: Western Michigan University, Anthropology Department, Kalamazoo, MI AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: Western Michigan University, Anthropology Department, has completed an... University, Anthropology Department. Disposition of the human remains and associated funerary objects to the...

  12. 75 FR 36671 - Notice of Inventory Completion: Western Michigan University, Anthropology Department, Kalamazoo, MI

    Science.gov (United States)

    2010-06-28

    ... University, Anthropology Department, Kalamazoo, MI AGENCY: National Park Service, Interior. ACTION: Notice... objects in the possession of Western Michigan University, Anthropology Department, Kalamazoo, MI. The... funerary objects should contact LouAnn Wurst, Department of Anthropology, Western Michigan University, 1005...

  13. Cost-Effectiveness Analysis of the Residential Provisions of the 2015 IECC for Michigan

    Energy Technology Data Exchange (ETDEWEB)

    Mendon, Vrushali V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zhao, Mingjie [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Taylor, Zachary T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Poehlman, Eric A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-02-15

    The 2015 IECC provides cost-effective savings for residential buildings in Michigan. Moving to the 2015 IECC from the 2009 IECC base code is cost-effective for residential buildings in all climate zones in Michigan.

  14. α -decay chains of superheavy Mt-279265 isotopes

    Science.gov (United States)

    Santhosh, K. P.; Nithya, C.

    2017-10-01

    The α -decay chains of the isotopes Mt-279265 are predicted by comparing the α half-lives calculated within the Coulomb and proximity potential model for deformed nuclei of Santhosh et al. [Nucl. Phys. A 850, 34 (2011)], 10.1016/j.nuclphysa.2010.12.002 with the spontaneous fission half-lives using the shell-effect-dependent formula of Santhosh and Nithya [Phys. Rev. C 94, 054621 (2016)], 10.1103/PhysRevC.94.054621. α half-lives also are calculated using different theoretical formalisms for comparison. The predicted half-lives and decay modes match well with the experimental results. The use of four different mass tables for calculating the α - decay energies indicates that the mass table of Wang et al. [Chin. Phys. C 41, 030003 (2017)], 10.1088/1674-1137/41/3/030003, which is based on the AME2016 atomic mass evaluation, is in better agreement with experimental results. The paper predicts long α chains from 265,267-269,271-273MT with half-lives within experimental limits. The isotopes 274-276,278Mt exhibit 2α chains followed by spontaneous fission. The 2α chain of 266Mt and the 4α chain of 270Mt end with electron capture. The isotopes Mt,279277 decay via spontaneous fission. We hope that the paper will open up new areas in this field.

  15. Geology and salt deposits of the Michigan Basin

    International Nuclear Information System (INIS)

    Johnson, K.S.; Gonzales, S.

    1976-07-01

    The Silurian-age Salina salt, one of the greatest deposits of bedded rock salt in the world, underlies most of the Michigan basin and parts of the Appalachian basin in Ohio. Pennsylvania, New York, and West Virginia. Interest in this salt deposit has increased in recent years because there may be one or more areas where it could be used safely as a repository for the underground storage of high-level radioactive wastes. The general geology of the Michigan basin is summarized and the major salt deposits are described in the hope that these data will be useful in determining whether there are any areas in the basin that are sufficiently promising to warrant further detailed study. Distribution of the important salt deposits in the basin is limited to the Southern Peninsula of Michigan

  16. Fast-food consumption and obesity among Michigan adults.

    Science.gov (United States)

    Anderson, Beth; Rafferty, Ann P; Lyon-Callo, Sarah; Fussman, Christopher; Imes, Gwendoline

    2011-07-01

    Consumption of meals eaten away from home, especially from fast-food restaurants, has increased in the United States since the 1970s. The main objective of this study was to examine the frequency and characteristics of fast-food consumption among adults in Michigan and obesity prevalence. We analyzed data from 12 questions about fast-food consumption that were included on the 2005 Michigan Behavioral Risk Factor Survey, a population-based telephone survey of Michigan adults, using univariate and bivariate analyses and multivariate logistic regression, and compared these data with data on Michigan obesity prevalence. Approximately 80% of Michigan adults went to fast-food restaurants at least once per month and 28% went regularly (≥2 times/wk). Regular fast-food consumption was higher among younger adults (mostly men) but was not significantly associated with household income, education, race, or urbanicity (in a multivariate framework). The prevalence of obesity increased consistently with frequenting fast-food restaurants, from 24% of those going less than once a week to 33% of those going 3 or more times per week. The predominant reason for choosing fast food was convenience. Although hypothetically 68% of adults who go to fast-food restaurants would choose healthier fast-food items when available, only 16% said they ever use nutritional information when ordering. The prevalence of fast-food consumption is high in Michigan across education, income, and racial groups and is strongly associated with obesity. Making nutritional information at fast-food restaurants more readily available and easier to use may help consumers to order more healthful or lower-calorie items.

  17. Qualitative: Python Tool for MT Quality Estimation Supporting Server Mode and Hybrid MT

    Directory of Open Access Journals (Sweden)

    Avramidis Eleftherios

    2016-10-01

    Full Text Available We are presenting the development contributions of the last two years to our Python opensource Quality Estimation tool, a tool that can function in both experiment-mode and online web-service mode. The latest version provides a new MT interface, which communicates with SMT and rule-based translation engines and supports on-the-fly sentence selection. Additionally, we present an improved Machine Learning interface allowing more efficient communication with several state-of-the-art toolkits. Additions also include a more informative training process, a Python re-implementation of QuEst baseline features, a new LM toolkit integration, an additional PCFG parser and alignments of syntactic nodes.

  18. 40 CFR 81.67 - Lake Michigan Intrastate Air Quality Control Region.

    Science.gov (United States)

    2010-07-01

    ... Quality Control Regions § 81.67 Lake Michigan Intrastate Air Quality Control Region. The Menominee-Escanaba (Michigan)-Marinette (Wisconsin) Interstate Air Quality Control Region has been renamed the Lake Michigan Intrastate Air Quality Control Region (Wisconsin) and revised to consist of the territorial area...

  19. 76 FR 28068 - Notice of Intent To Repatriate Cultural Items: Museum of Anthropology, University of Michigan...

    Science.gov (United States)

    2011-05-13

    ... Cultural Items: Museum of Anthropology, University of Michigan, Ann Arbor, MI AGENCY: National Park Service... Museum of Anthropology, University of Michigan, Ann Arbor, MI, that meet the definition of unassociated... funerary objects should contact Carla Sinopoli, Museum of Anthropology, University of Michigan, Ann Arbor...

  20. 78 FR 45057 - Safety Zone; Alpena Area HOG Rally Fireworks, Alpena, Michigan

    Science.gov (United States)

    2013-07-26

    ...-AA00 Safety Zone; Alpena Area HOG Rally Fireworks, Alpena, Michigan AGENCY: Coast Guard, DHS. ACTION... rally in Alpena, Michigan with a fireworks display. Fireworks will be launched near the end of Mason Street, South of State Avenue, approximately 50 yards west of Thunder Bay in Alpena, Michigan. The...

  1. HR diagrams derived from the Michigan Spectral Catalogue

    International Nuclear Information System (INIS)

    Houk, N.; Fesen, R.

    1978-01-01

    The authors present some HR diagrams constructed using data from the Michigan Spectral Catalogues. Houk (1975) has been systematically reclassifying the Henry Draper stars on the MK system, from the south pole northward. Objective-prism plates, with a reciprocal dispersion of 108 A/mm, have been taken with the Michigan Curtis Schmidt telescope at Cerro Tololo Inter-American Observatory in Chile. The spectra are classified visually from the plates, and the results are put onto IBM cards and magnetic tape from which the catalogues are produced. (Auth.)

  2. Michigan Health & Hospital Association Keystone Obstetrics: a statewide collaborative for perinatal patient safety in Michigan.

    Science.gov (United States)

    Simpson, Kathleen Rice; Knox, G Eric; Martin, Morgan; George, Chris; Watson, Sam R

    2011-12-01

    Preventable harm to mothers and infants during labor and birth is a significant patient safety and professional liability issue. A Michigan Health & Hospital Association Keystone Center for Patient Safety & Quality Obstetric Collaborative Project involved perinatal teams from 15 Michigan hospitals during an 11-month period in 2009. The purpose of the project was to promote safe care practices during labor and birth using the Comprehensive Unit-based Safety Program (CUSP). Consistent with the CUSP model, this project's components included assessing and promoting a culture of safety; interdisciplinary team building; case review; learning from defects through multiple methods of education; team and individual coaching and peer encouragement; administrative support for the establishment of a fundamental safety infrastructure; and ongoing evaluation of care processes and outcomes. Study measures included 32 components of a perinatal patient infrastructure, 6 care processes during labor and birth, and 4 neonatal outcomes. Significant improvements were found in the safety culture (Safety Attitudes Questionnaire), the perinatal patient safety infrastructure components, and all care processes. Although the project was successful, getting buy-in from all members of the clinical team in each hospital for all of the measures was challenging at times. There was initial resistance to some of the measures and their various expected aspects of care. For example, some of the clinicians were initially reluctant to adopt the recommended standardized oxytocin protocol. Peer encouragement and unit-based feedback on progress in minimizing early elective births proved useful in many hospitals. A CUSP in obstetrics can be beneficial in improving the care of mothers and infants during labor and birth.

  3. Collaboration between the University of Michigan Taubman Health Sciences library and the University of Michigan Medical School Office of Research.

    Science.gov (United States)

    Black, Christine; Harris, Bethany; Mahraj, Katy; Schnitzer, Anna Ercoli; Rosenzweig, Merle

    2013-01-01

    Librarians have traditionally facilitated research development resulting in grants through performing biomedical literature searches for researchers. The librarians at the Taubman Health Sciences Library of the University of Michigan have taken additional steps forward by instituting a proactive approach to assisting investigators. To accomplish this, the librarians have taken part in a collaborative effort with the University of Michigan Medical School Office of Research. Through this partnership, both units have created and adopted various techniques intended to facilitate the submission of grants, thus allowing researchers more time to conduct their primary activities.

  4. mtDNA, Metastasis, and the Mitochondrial Unfolded Protein Response (UPRmt).

    Science.gov (United States)

    Kenny, Timothy C; Germain, Doris

    2017-01-01

    While several studies have confirmed a link between mitochondrial DNA (mtDNA) mutations and cancer cell metastasis, much debate remains regarding the nature of the alternations in mtDNA leading to this effect. Meanwhile, the mitochondrial unfolded protein response (UPR mt ) has gained much attention in recent years, with most studies of this pathway focusing on its role in aging. However, the UPR mt has also been studied in the context of cancer. More recent work suggests that rather than a single mutation or alternation, specific combinatorial mtDNA landscapes able to activate the UPR mt may be those that are selected by metastatic cells, while mtDNA landscapes unable to activate the UPR mt do not. This review aims at offering an overview of the confusing literature on mtDNA mutations and metastasis and the more recent work on the UPR mt in this setting.

  5. Michigan field artillery's 'Blackjacks' training in Latvia > National Guard

    Science.gov (United States)

    Charles Smith, 1st Battalion, 119th Field Artillery, Michigan Army National Guard, set up the M67 GLPS for 24 years. 1st. Lt. Brice Masterson, and Sgt. 1st Class Charles Smith, 1st Battalion, 119th Field , Lithuania and the United States will participate in the exercise. The exercise takes place at Adazi Training

  6. Commentary on the Discovery of the Beautiful Style Michigan Madonna

    Czech Academy of Sciences Publication Activity Database

    Hlobil, Ivo

    2016-01-01

    Roč. 64, 3/4 (2016), s. 256-260 ISSN 0049-5123 Institutional support: RVO:68378033 Keywords : gothic sculpture * Bohemian Beautiful Style * Madonna-torso * Museum Ann Arbor * Michigan ( USA ) Subject RIV: AL - Art, Architecture, Cultural Heritage

  7. Timber resource of Michigan's Southern Lower Peninsula Unit, 1980.

    Science.gov (United States)

    Jerold T. Hahn

    1982-01-01

    The fourth inventory of the timber resource of Michigan's Southern Lower Peninsula Survey Unit shows a 12% decline in commercial forest area and a 26% gain in growing-stock volume between 1966 and 1980. Presented are highlights and statistics on area, volume, growth, mortality, removals, utilization, and biomass.

  8. The changing veneer and plywood industry of Michigan and Wisconsin.

    Science.gov (United States)

    Gary R. Lindell; Lewis T. Hendricks

    1972-01-01

    Analyzes trends in the hardwood veneer and plywood industry of Michigan and Wisconsin between 1964 and 1969. In that period, red oak and hard maple replaced yellow birch as the major species used. Log supplies were adequate. Wall paneling was the major end market with doorskins next. Excess plywood producing capacity is a chronic problem.

  9. Understanding public opinion regarding transit in southeast Michigan.

    Science.gov (United States)

    2015-04-01

    This report presents findings from a study on public opinion regarding transit in Southeast Michigan. The overall goals of this : study were to assess the nature of public opinion regarding regional transit and to understand its relation to socio-dem...

  10. National Uranium Resource Evaluation: Iron River Quadrangle, Michigan and Wisconsin

    Energy Technology Data Exchange (ETDEWEB)

    Frishman, D

    1982-09-01

    No area within the Iron River 1/sup 0/ x 2/sup 0/ Quadrangle, Michigan and Wisconsin, appears to be favorable for the existence of a minimum of 100 tons of U/sub 3/O/sub 8/ at a grade of 0.01 percent or better.

  11. Digital Learning Compass: Distance Education State Almanac 2017. Michigan

    Science.gov (United States)

    Seaman, Julia E.; Seaman, Jeff

    2017-01-01

    This brief report uses data collected under the U.S. Department of Education's National Center for Educational Statistics (NCES) Integrated Postsecondary Education Data System (IPEDS) Fall Enrollment survey to highlight distance education data in the state of Michigan. The sample for this analysis is comprised of all active, degree-granting…

  12. A post-Calumet shoreline along southern Lake Michigan

    Science.gov (United States)

    Capps, D.K.; Thompson, T.A.; Booth, R.K.

    2007-01-01

    The southern shore of Lake Michigan is the type area for many of ancestral Lake Michigan's late Pleistocene lake phases, but coastal deposits and features of the Algonquin phase of northern Lake Michigan, Lake Huron, and Lake Superior are not recognized in the area. Isostatic rebound models suggest that Algonquin phase deposits should be 100 m or more below modern lake level. A relict shoreline, however, exists along the lakeward margin of the Calumet Beach that was erosional west of Deep River and depositional east of the river. For this post-Calumet shoreline, the elevation of basal foreshore deposits east of Deep River and the base of the scarp west of Deep River indicate a slightly westward dipping water plane that is centered at ???184 m above mean sea level. Basal foreshore elevations also indicate that lake level fell ???2 m during the development of the shoreline. The pooled mean of radiocarbon dates from the surface of the peat below post-Calumet shoreline foreshore deposits indicate that the lake transgressed over the peat at 10,560 ?? 70 years B.P. Pollen assemblages from the peat are consistent with this age. The elevation and age of the post-Calumet shoreline are similar to the Main Algonquin phase of Lake Huron. Recent isostatic rebound models do not adequately address a high-elevation Algonquin-age shoreline along the southern shore of Lake Michigan, but the Goldthwait (1908) hinge-line model does. ?? 2006 Springer Science+Business Media B.V.

  13. An Interdisciplinary International Business Degree at Eastern Michigan University

    Science.gov (United States)

    Victor, David A.

    2008-01-01

    In January 2006, the College of Business at Eastern Michigan University (EMU) instituted a cross-disciplinary program in international business (IB). Business communication is a major component of the program. Moreover, the need for business communication in other languages contributed greatly to the cross-disciplinary nature of the program. This…

  14. Importance-performance analysis: an application to Michigan's natural resources

    Science.gov (United States)

    Gloria Sanders; Erin White; Lori Pennington-Gray

    2001-01-01

    In the state of Michigan, the nature-based tourist is becoming an increasingly important target market for providers of natural resources. To meet the demands of this growing market segment, evaluation strategies for nature-based sites are needed to maintain and improve customer satisfaction and loyalty. Evaluation strategies that incorporate consumer input can help to...

  15. Post Audit of Lake Michigan Lake Trout PCB Model Forecasts

    Science.gov (United States)

    The Lake Michigan (LM) Mass Balance Study was conducted to measure and model polychlorinated biphenyls (PCBs) and other anthropogenic substances to gain a better understanding of the transport, fate, and effects of these substances within the system and to aid managers in the env...

  16. Michigan Physicians' Conference on Elder Abuse. Final Report.

    Science.gov (United States)

    Sengstock, Mary C.; O'Brien, James G.

    The final report describes the Michigan Physicians' Conference on Elder Abuse project. The project conference had four major content areas, including: a general introduction to the problem of elder abuse; clinical symptoms of abuse; legal issues; and referral and case management techniques. Training techniques included lectures, group discussion,…

  17. Grip and Pinch Strength Norms for Michigan Workers

    Directory of Open Access Journals (Sweden)

    Joel M. Phillips M.S., OTRL

    2013-06-01

    Full Text Available The purpose of this study was to create a norm reference of current grip and pinch strength norms for working-age Michigan adults. This normative study included a convenience sample of 179 volunteers who were employees at car plants in South East Michigan or hospital sites in West Michigan. Participants’ ages ranged from between 20 and 62 years of age with a mean age of 49.15 years. There were 78 females (44% and 101 males (56%. Subjects were classified by gender and in the age categories of ages 20 to 49 years and ages 50-62 years. Grip and pinch strength norms were collected following the American Society of Hand Therapy protocol. The norms from these working adults were calculated with descriptive statistics for males and females in two age classifications: ages 20 to 49 and ages 50 to 62 years. Standard Errors (SE are better than the 1985 norms for both males and females ages 20 to 49 years. SEs are higher than the ages 20 to 49 years’ norms for the ages 50 to 62 years age categories in both males and females. These norms offer a point of comparison for clinicians to use for clients in Michigan who are ages 20 to 62 years and who have a goal to improve their grip strength. Clients’ grip and pinch strength could be compared to their age level or gender norms using the comparison for one standard deviation above, below, or at the means.

  18. Selected Collective Bargaining Agreements of Michigan Two-Year Colleges.

    Science.gov (United States)

    National Education Association, Washington, DC.

    Collective bargaining agreements of 19 selected Michigan two-year colleges are presented, representing contracts in effect in 1987. Contracts for the following colleges are included: Alpena Community College, Bay de Noc Community College, Gogebic Community College, Grand Rapids Junior College, Kalamazoo Valley Community College, Kellogg Community…

  19. Telecommuting for Original Cataloging at the Michigan State University Libraries.

    Science.gov (United States)

    Black, Leah; Hyslop, Colleen

    1995-01-01

    Working conditions in library technical services departments can be a problem for catalogers in need of a quiet work environment. Based on a successful program for indexers at the National Agriculture Library, a proposal for an experimental telecommuting program for original cataloging at the Michigan State University Libraries was developed and…

  20. Environmental indices for common Michigan trees and shrubs.

    Science.gov (United States)

    Gary J. Brand

    1985-01-01

    Plants are indicators of environmental factors like moisture, nutrients, heat, and light. Semi-quantitative indices for these four factors were developed for 90 Michigan trees and shrubs. The indices and a tally of species present provide a simple evaluation of the environment of a forest stand and a useful management aid.

  1. The University of Michigan's Computer-Aided Engineering Network.

    Science.gov (United States)

    Atkins, D. E.; Olsen, Leslie A.

    1986-01-01

    Presents an overview of the Computer-Aided Engineering Network (CAEN) of the University of Michigan. Describes its arrangement of workstations, communication networks, and servers. Outlines the factors considered in hardware and software decision making. Reviews the program's impact on students. (ML)

  2. Processing United Nations Documents in the University of Michigan Library.

    Science.gov (United States)

    Stolper, Gertrude

    This guide provides detailed instructions for recording documents in the United Nations (UN) card catalog which provides access to the UN depository collection in the Harlan Hatcher Graduate Library at the University of Michigan. Procedures for handling documents when they are received include stamping, counting, and sorting into five categories:…

  3. Nuclear collapse observed during the eruption of Mt. Usu

    International Nuclear Information System (INIS)

    Matsumoto, Taka-aki

    2002-01-01

    Mt. Usu which was located about 70 km southwest from Sapporo in Hokkaido (the north island of Japan) began to erupt on March 31 in 2000. A nuclear emulsion was placed on a foot of Mt. Usu to catch small atomic clusters which were expected to be emitted during the eruption. Curious atomic clusters and their reaction products were successfully observed on surfaces of the nuclear emulsion. By comparing them with similar products which were obtained in previous experiments of discharge and electrolysis, it was concluded that micro Ball Lightning was really emitted during the eruption of Mt. Usu and that explosive reactions by nuclear collapse could have been involved to contribute to energy of the eruption. (author)

  4. Alterations in mtDNA, gastric carcinogenesis and early diagnosis.

    Science.gov (United States)

    Rodrigues-Antunes, S; Borges, B N

    2018-05-26

    Gastric cancer remains one of the most prevalent cancers in the world. Due to this, efforts are being made to improve the diagnosis of this neoplasm and the search for molecular markers that may be involved in its genesis. Within this perspective, the mitochondrial DNA is considered as a potential candidate, since it has several well documented changes and is readily accessible. However, numerous alterations have been reported in mtDNA, not facilitating the visualization of which alterations and molecular markers are truly involved with gastric carcinogenesis. This review presents a compilation of the main known changes relating mtDNA to gastric cancer and their clinical significance.

  5. Expression of the MT1 Melatonin Receptor in Ovarian Cancer Cells

    Directory of Open Access Journals (Sweden)

    Karolina Jablonska

    2014-12-01

    Full Text Available Ovarian cancer (OC is the leading cause of death among women with genital tract disorders. Melatonin exhibits oncostatic properties which it may effect through binding to its membrane receptor, MT1. The aim of this study was to determine the expression of MT1 in OC cells and to correlate this with clinical and pathological data. Immunohistochemistry was performed on 84 cases of OC. Normal ovarian epithelial (IOSE 364 and OC (SK-OV-3, OVCAR-3 cell lines were used to examine the MT1 expression at protein level using the western blot and immunofluorescence technique. The expression of MT1 was observed as cytoplasmic-membrane (MT1CM and membrane (MT1M reactions. A positive correlation between MT1CM and MT1M was found in all the studied cases. There were no significant differences between the expression of MT1CM, MT1M, and histological type, staging, grading, presence of residual disease, or overall survival time. Immunofluorescence showed both MT1M and MT1CM expression in all the tested cell lines. Western blot illustrated the highest protein level of MT1 in IOSE 364 and the lowest in the OVCAR-3. The results indicate the limited prognostic significance of MT1 in OC cells.

  6. Saksa abituurium Eestis : [Tallinna Saksa Gümnaasium] / Clemens Krause

    Index Scriptorium Estoniae

    Krause, Clemens Hermann, 1943-

    2002-01-01

    Gümnaasiumis on saksakeelne osakond, mille eesmärk on saksa abituurium. Komplitseeritud süsteemis, mis koosneb kohustuslikest ja valikainetest, kahe viimase aasta hinnetest ja eksamihinnetest, antakse punkte, mis kokku arvestatuna määravad, kas abituurium on sooritatud või mitte. See on kogu Euroopas ainulaadne mudel : eesti ja saksa abituurium on omavahel seotud

  7. Kahes Eesti koolis avatakse saksakeelsed osakonnad / Annette Priess, Clemens Krause

    Index Scriptorium Estoniae

    Priess, Annette

    1997-01-01

    Tallinna 54. Keskkoolis ja Tartu 3. Keskkoolis avatakse saksakeelsed osakonnad, mille lõpetanud saavad nii Eesti kui Saksa keskkooli lõputunnistuse ning võivad asuda edasi õppima Eesti või Saksa kõrgkoolidesse.

  8. FINAL TECHNICAL REPORT FOR FORESTRY BIOFUEL STATEWIDE COLLABORATION CENTER (MICHIGAN)

    Energy Technology Data Exchange (ETDEWEB)

    LaCourt, Donna M.; Miller, Raymond O.; Shonnard, David R.

    2012-04-24

    A team composed of scientists from Michigan State University (MSU) and Michigan Technological University (MTU) assembled to better understand, document, and improve systems for using forest-based biomass feedstocks in the production of energy products within Michigan. Work was funded by a grant (DE-EE-0000280) from the U.S. Department of Energy (DOE) and was administered by the Michigan Economic Development Corporation (MEDC). The goal of the project was to improve the forest feedstock supply infrastructure to sustainably provide woody biomass for biofuel production in Michigan over the long-term. Work was divided into four broad areas with associated objectives: • TASK A: Develop a Forest-Based Biomass Assessment for Michigan – Define forest-based feedstock inventory, availability, and the potential of forest-based feedstock to support state and federal renewable energy goals while maintaining current uses. • TASK B: Improve Harvesting, Processing and Transportation Systems – Identify and develop cost, energy, and carbon efficient harvesting, processing and transportation systems. • TASK C: Improve Forest Feedstock Productivity and Sustainability – Identify and develop sustainable feedstock production systems through the establishment and monitoring of a statewide network of field trials in forests and energy plantations. • TASK D: Engage Stakeholders – Increase understanding of forest biomass production systems for biofuels by a broad range of stakeholders. The goal and objectives of this research and development project were fulfilled with key model deliverables including: 1) The Forest Biomass Inventory System (Sub-task A1) of feedstock inventory and availability and, 2) The Supply Chain Model (Sub-task B2). Both models are vital to Michigan’s forest biomass industry and support forecasting delivered cost, as well as carbon and energy balance. All of these elements are important to facilitate investor, operational and policy decisions. All

  9. Ezra Pound and Du Fu: Gazing at Mt. Tai

    Directory of Open Access Journals (Sweden)

    Kent Su

    2017-08-01

    Full Text Available Confined to a six-by-six-foot outdoor steel cage, Ezra Pound saw a series of mountain hills from a few miles to the east of Pisa. The poet compared one of these small 800-metre hills to the sacred Chinese Mt. Tai, which becomes the most common geographical name in The Pisan Cantos. Pound’s poetic summoning of this particular mountain is related to the fact that Mt. Tai is historically and culturally connected to the philosophy of Confucius, who personally ascended the mountain several times. Pound, as a devout Confucian disciple, closely follows the philosophical doctrines and attempts to mentally trace the footsteps of Confucius. This paper will argue how Pound’s poetic evocation of the mountain shares a striking similarity to an eighth-century Chinese poem called “Gazing at Mt. Tai,” which was written by the famous literatus - Du Fu 杜甫(712 – 770 . In spite of living in two completely different eras and countries, Pound’s and Du Fu’s reference to Mt. Tai demonstrates the confluence of their poetic spirits. Neither of them ascended mountain personally. They instead made use of their poetic imagination to follow the paths of Confucius and perceived the mountain as an earthly paradise, one which represents tranquillity and serenity away from the moral and physical corruption of the external world.

  10. Ethnobotanical study of medicinal plants used by sabaots of Mt ...

    African Journals Online (AJOL)

    ... medicinal plant species used to manage human ailments at Kopsiro Division Mt. ... The whole plant (1.8%), seed (1.2%), fruit (1.2%), sap (1.2%), flower (0.6%) ... as to maximize the sustainable use of these vital resources in the study area.

  11. 77 FR 44120 - Establishment of Class E Airspace; Roundup, MT

    Science.gov (United States)

    2012-07-27

    ... Association (NBAA). The NBAA comments recommended that the FAA lower some of the adjacent Class E airspace...-0274; Airspace Docket No. 12-ANM-4] Establishment of Class E Airspace; Roundup, MT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action establishes Class E airspace...

  12. MtDNA T4216C variation in multiple sclerosis

    DEFF Research Database (Denmark)

    Andalib, Sasan; Emamhadi, Mohammadreza; Yousefzadeh-Chabok, Shahrokh

    2016-01-01

    MtDNA T4216C variation has frequently been investigated in Multiple Sclerosis (MS) patients; nonetheless, controversy has existed about the evidence of association of this variation with susceptibility to MS. The present systematic review and meta-analysis converge the results of the preceding pu...

  13. Deep underground multiple muons at the Mt. Blanc station

    Energy Technology Data Exchange (ETDEWEB)

    Bergamasco, L; Bilokon, H; D' Ettorre Piazzoli, B; Mannocchi, G [Consiglio Nazionale delle Ricerche, Turin (Italy). Lab. di Cosmo-Geofisica; Castagnoli, C; Picchi, P [Consiglio Nazionale delle Ricerche, Turin (Italy). Lab. di Cosmo-Geofisica; Turin Univ. (Italy). Ist. di Fisica Generale)

    1979-12-29

    Results on multiple events recorded at the Mt. Blanc station in the last 3 years are presented. The integral energy spectrum of muons is obtained for Esub(..mu..)>1 TeV in the size range 10/sup 6/ - 10/sup 7/ which favours a multiplicity law for hadronic interactions of the form eta approximately Esup(1/4).

  14. 78 FR 67024 - Establishment of Class E Airspace; Glasgow, MT

    Science.gov (United States)

    2013-11-08

    ... aid, Glasgow, MT. A favorable comment from the National Business Aviation Association (NBAA) was.... SUPPLEMENTARY INFORMATION: History The FAA published a final rule in the Federal Register establishing Class E..., pursuant to the authority delegated to me, the description under the History heading, as published in the...

  15. Conflicting Values: Spirituality and Wilderness at Mt. Shasta

    Science.gov (United States)

    Maria Fernandez-Gimenez; Lynn Huntsinger; Catherine Phillips; Barbara Allen-Diaz

    1992-01-01

    Many people from a variety of backgrounds believe that Mt. Shasta is a major spiritual center. Although these "spiritual users" value the area's natural features, their spiritual and social activities, including construction of sweat lodges, medicine wheels, altars, meditation pads, trails, and campsites, are leading to rapid ecological degradation. This...

  16. 77 FR 55690 - Amendment of Class E Airspace; Dillon, MT

    Science.gov (United States)

    2012-09-11

    ... aircraft using new Area Navigation (RNAV) Global positioning System (GPS) standard instrument approach... Airport, Dillon, MT, to accommodate IFR aircraft executing new RNAV (GPS) standard instrument approach.... Steven L. Vale, Acting Manager, Operations Support Group, Western Service Center. [FR Doc. 2012-22269...

  17. 76 FR 40322 - Mt. Hood Meadows Ski Resort Parking Improvements

    Science.gov (United States)

    2011-07-08

    ... fleet. Also, the location of the current maintenance shop impedes traffic flow and removes potential... new Sunrise Vehicle Maintenance Shop on the north side of the Sunrise parking lot. DATES: Comments... increasing parking capacity and improving traffic flow in at Mt. Hood Meadows Ski Resort. Parking capacity...

  18. 76 FR 9991 - Television Broadcasting Services; Kalispell, MT

    Science.gov (United States)

    2011-02-23

    ... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 [DA 11-224; MB Docket No. 11-20; RM-11619] Television Broadcasting Services; Kalispell, MT AGENCY: Federal Communications Commission. ACTION: Proposed... 73 Television, Television broadcasting. For the reasons discussed in the preamble, the Federal...

  19. 76 FR 27914 - Television Broadcasting Services; Kalispell, MT

    Science.gov (United States)

    2011-05-13

    ... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 [MB Docket No. 11-20; RM-11619, DA 11-750] Television Broadcasting Services; Kalispell, MT AGENCY: Federal Communications Commission. ACTION: Final rule... U.S.C. 801(a)(1)(A). [[Page 27915

  20. Human mitochondrial DNA (mtDNA) types in Malaysia

    International Nuclear Information System (INIS)

    Lian, L.H.; Koh, C.L.; Lim, M.E.

    2000-01-01

    Each human cell contains hundreds of mitochondria and thousands of double-stranded circular mtDNA. The delineation of human mtDNA variation and genetics over the past decade has provided unique and often startling insights into human evolution, degenerative diseases, and aging. Each mtDNA of 16,569 base pairs, encodes 13 polypeptides essential to the enzymes of the mitochondrial energy generating pathway, plus the necessary tRNAs and rRNAs. The highly polymorphic noncoding D-(displacement) loop region, also called the control region, is approximately 1.2 kb long. It contains two well-characterized hypervariable (HV-) regions, HV1 and HV2. MtDNA identification is usually based on these sequence differences. According to the TWTGDAM (Technical Working Group for DNA Analysis Methods), the minimum requirement for a mtDNA database for HV1 is from positions 16024 to 16365 and for HV2, from positions 00073 to 00340. The targeted Malaysian population subgroups for this study were mainly the Malays, Chinese, Indians, and indigenous Ibans, Bidayuhs, Kadazan-Dusuns, and Bajaus. Research methodologies undertaken included DNA extraction of samples from unrelated individuals, amplification of the specific regions via the polymerase chain reaction (PCR), and preparation of template DNA for sequencing by using an automated DNA sequencer. Sufficient nucleotide sequence data were generated from the mtDNA analysis. When the sequences were analyzed, sequence variations were found to be caused by nucleotide substitutions, insertions, and deletions. Of the three causes of the sequence variations, nucleotide substitutions (86.1%) accounted for the vast majority of polymorphism. It is noted that transitions (83.5%) were predominant when compared to the significantly lower frequencies of transversions (2.6%). Insertions (0.9%) and deletions (13.0%) were rather rare and found only in HV2. The data generated will also form the basis of a Malaysian DNA sequence database of mtDNA D

  1. The Scholarly Communication Process within the University Research Corridor (Michigan State University, the University of Michigan, and Wayne State University): A Case Study in Cooperation

    Science.gov (United States)

    Utter, Timothy; Holley, Robert P.

    2009-01-01

    The growth of open access publishing, the development of institutional repositories, and the availability of millions of digitized monographs and journals are rapidly changing scholarly communication. This case study looks at the current and possible uses of these tools by Michigan's three largest universities: Michigan State University, the…

  2. Water resources of the Flint area, Michigan

    Science.gov (United States)

    Wiitala, Sulo Werner; Vanlier, K.E.; Krieger, Robert A.

    1964-01-01

    sand and gravel also fill some of the valleys in the bedrock surface and yield moderate to large supplies of water. Production from public supply wells tapping the drift aquifers in the area ranges from about 50 to 1,200 gpm. The water from the drift aquifer is hard or very hard and commonly contains objectionable amounts of iron.The Saginaw formation is a source of water to wells supplying some of the small communities and industries in the county. The Saginaw, which is the uppermost bedrock formation in the area, underlies most of the county. It is composed of layers of sandstone, shale, and limestone and some beds of coal. The formation is composed principally of sandstone in some areas of the county, and shale in others. Production from wells tapping the Saginaw ranges from a few to about 500 gpm. The water produced is generally moderately hard or hard and commonly contains objectionable amounts of chloride. The quality of the water limits its development for water supply. Overdrafts from the Saginaw result in a lowering of the piezometric surface and commonly cause an upward migration of water high in chloride.The Michigan and Marshall formations are generally not sources of fresh water where they are overlain by the Saginaw formation. In the southern and eastern parts of the county where they are overlain by glacial deposits, they are a source of water of good quality. The quantity of water obtainable from these formations is not fully known. However, the Marshall may be a source of large supplies of water in the southeastern part of the county.An ample supply of water is available in lakes, ponds, and streams in the metropolitan area of Flint to meet requirements for domestic, sanitary, and firefighting use in civil defense emergencies. The extent of emergency use of water from these sources would depend upon the pumping, distribution, and treatment facilities available. Enough private industrial and commercial, and public wells are present in the area normally

  3. Recent geologic development of Lake Michigan (U.S.A.)

    Science.gov (United States)

    Gross, D.L.; Cahill, R.A.

    1983-01-01

    The stresses placed on Lake Michigan since the advent of industrialization require knowledge of the sedimentology of the whole lake in order to make informed decisions for environmental planning. Sediment accumulation rates are low: areas of the lake receiving the most sediment average only 1 mm a-1; deep-water basins average 0.1 to 0.5 mm a-1; and large areas are not receiving any sediment. Sediment was deposited rapidly (typically 5 mm a-1), in the form of rock flour, during the deglaciation of both Lake Michigan and Lake Superior Basins. Then the rate of accumulation decreased by 80-90% and has remained relatively constant since final deglaciation. Because active sedimentation occurs mostly in the deep water areas of the lake, the sediment remains undisturbed and contains a record of the chemical history of the lake. ?? 1983 Dr W. Junk Publishers.

  4. Impact of cooling systems on Lake Michigan fishes

    International Nuclear Information System (INIS)

    Spigarelli, S.A.; Romberg, G.P.

    1976-01-01

    A comparison of data on fish mortalities due to impingement at thermal power plant water intakes on Lake Michigan with available estimates of standing crop biomass, commercial and sport fishery catches, and estimated predation mortality is presented. The striking features of these data are the proportions of total mortality due to predation and the lack of accurate basic population statistics such as standing crop biomass and natural mortality for important forage and human food fishes in Lake Michigan. Although this preliminary assessment would indicate that power plant and total impingement losses constitute an insignificant fraction of total forage biomass, the potentially unstable forage-predator ratios and the apparent high degree of annual fluctuations (year-classes) in alewife, smelt, and perch indicate the need for a more detailed assessment of cooling-system related impact on selected populations

  5. Acid rain stimulation of Lake Michigan phytoplankton growth

    Science.gov (United States)

    Manny, Bruce A.; Fahnenstiel, G.L.; Gardner, W.S.

    1987-01-01

    Three laboratory experiments demonstrated that additions of rainwater to epilimnetic lake water collected in southeastern Lake Michigan stimulated chlorophyll a production more than did additions of reagent-grade water during incubations of 12 to 20 d. Chlorophyll a production did not begin until 3–5 d after the rain and lake water were mixed. The stimulation caused by additions of rain acidified to pH 3.0 was greater than that caused by additions of untreated rain (pH 4.0–4.5). Our results support the following hypotheses: (1) Acid rain stimulates the growth of phytoplankton in lake water; (2) phosphorus in rain appears to be the factor causing this stimulation. We conclude that acid rain may accelerate the growth of epilimnetic phytoplankton in Lake Michigan (and other similar lakes) during stratification when other sources of bioavailable phosphorus to the epilimnion are limited

  6. 239 240Pu in Lake Michigan: 1971 to 1978

    International Nuclear Information System (INIS)

    Wahlgren, M.A.; Nelson, D.M.; Orlandini, K.A.; Kucera, E.T.

    1978-01-01

    The plutonium concentration data presented previously have consisted primarily of results from studies of short-term variations, i.e., the annual plutonium cycle conducted at Lake Michigan station ANL-5, 12 km SW of Grand Haven, Michigan. In this report, mean annual concentrations of total plutonium in unfiltered water from far off-shore (> 30 km) stations for the period 1971 through 1977, and from station ANL-5 (1975 through 1978) are summarized to establish the long-term trend in plutonium concentration in Lake Michigan. The results presented show that the mean annual concentration in the water column is similar at ANL-5 and at offshore stations and has decreased at the rate of only 6% per year during the period 1972 through 1978. The nearly constant concentration indicates that steady-state equilibria exist between plutonium inputs to the lake and the loss of plutonium from the water column. Observations suggest the existence of an active redox cycle for Pu in Lake Michigan. In this cycle, Pu IV atoms in solution are continually taken up by particulate materials but may be oxidized within microzones of the particles such as freshly deposited manganese coatings and also in solution by agents such as dissolved oxygen. In turn, the concentration of Pu VI in solution may be limited by reaction with reducing constituents of the coloidal-sized fraction (or decomposer organisms such as bacteria or fungi, which might have been present after filtration) and with planktonic organisms in the environment to produce Pu IV and thus maintain the cycle

  7. Prostate Cancer Clinical Trials Group: The University of Michigan Site

    Science.gov (United States)

    2012-04-01

    Michigan Cancer Center, Ann Arbor, MI Abstract Disclosures Abstract: Background: Cabozantinib ( Cabo ) is an inhibitor of MET and VEGFR2. MET signaling...promotes tumor growth, invasion and metastasis. Methods: mCRPC patients (pts) with progressive measurable disease (mRECIST) received Cabo at 100 mg...qd PO over a 12 week (wk) lead-in stage. Response was assessed q6 wks. Treatment ≥ wk 12 was based on response: pts with PR continued open-label Cabo

  8. Passive solar homes in Michigan's Upper Peninsula

    Energy Technology Data Exchange (ETDEWEB)

    Kindred, G.F. [Garfield Kindred Associates, Hancock, MI (United States)

    2001-07-01

    This paper discussed the construction and design of 3 affordable passive solar homes located in high latitudes: (1) the Kindred house located in a wooded subdivision in Hancock, Michigan; (2) the Autio house located in Laurium, Michigan; and the Mikkola house located in South Range, Michigan. The award-winning houses were part of the United States federal government's Energy Star program. The houses were constructed with common building materials in order to introduce the general public to the principles of energy-conscious passive solar design strategies and sustainable construction technologies. Super-insulation was used to retain solar heat gain in the houses. Air infiltration was minimized through the use of an airtight drywall sealing technique. Large windows were a prominent feature of the southern facades of the houses. The windows used fixed and casement low-e argon-filled insulated glazing. Average bills for the Kindred home are US$960 per year. It was concluded that passive solar design and construction strategies are now being used more often in the area as a result of the positive media coverage that the homes has received. 5 refs.

  9. 76 FR 19281 - Proposed Amendment of Class E Airspace; Bozeman, MT

    Science.gov (United States)

    2011-04-07

    ... Instrument Landing System (ILS) Localizer (LOC) standard instrument approach procedures at the airport. The... extending upward from 700 feet or more above the surface of the earth. * * * * * ANM MT E5 Bozeman, MT...

  10. Answers to questions posed by the Michigan Governor's Nuclear Waste Disposal Task Force

    International Nuclear Information System (INIS)

    1976-01-01

    A general presentation of the National Waste Terminal Storage (NWTS) Program was given on July 26, 1976, to the Michigan Environmental Review Board and the Michigan Governor's Nuclear Waste Disposal Task Force. Following the presentation, Dr. William G. Taylor, Chairman of the Task Force, provided ERDA with a listing of questions which pertained to the NWTS program and ERDA/OWI's interest in northeast Michigan. This document contains copies of the information which was provided to Dr. Taylor in response to his inquiry

  11. Environmental status of the Lake Michigan region. Volume 16. Amphibians and reptiles of the Lake Michigan drainage basin

    Energy Technology Data Exchange (ETDEWEB)

    Pentecost, E.D.; Vogt, R.C.

    1976-07-01

    The focus of this report is on regional distribution of the herpetofauna of the Lake Michigan Drainage Basin. The introduction includes a brief discussion of plant communities and their associated herpetofauna, and the importance of hibernacula and migration routes. Some aspects of the status, distribution, habitat, and life history of the amphibians and reptiles of the Basin are described in an annotated checklist. Special attention is given to uncommon and endangered species. Species range is shown on distribution maps.

  12. Environmental status of the Lake Michigan region. Volume 16. Amphibians and reptiles of the Lake Michigan drainage basin

    International Nuclear Information System (INIS)

    Pentecost, E.D.; Vogt, R.C.

    1976-07-01

    The focus of this report is on regional distribution of the herpetofauna of the Lake Michigan Drainage Basin. The introduction includes a brief discussion of plant communities and their associated herpetofauna, and the importance of hibernacula and migration routes. Some aspects of the status, distribution, habitat, and life history of the amphibians and reptiles of the Basin are described in an annotated checklist. Special attention is given to uncommon and endangered species. Species range is shown on distribution maps

  13. Ground-water contamination and legal controls in Michigan

    Science.gov (United States)

    Deutsch, Morris

    1963-01-01

    The great importance of the fresh ground-water resources of Michigan is evident because 90 percent of the rural and about 70 percent of the total population of the State exclusive of the Detroit metropolitan area are supplied from underground sources. The water-supply and public-health problems that have been caused by some cases of ground-water contamination in the State illustrate the necessity of protecting this vital resource.Manmade and natural contaminants, including many types of chemical and organic matter, have entered many of the numerous aquifers of the State. Aquifers have been contaminated by waste-laden liquids percolating from the surface or from the zone of aeration and by direct injection to the aquifer itself. Industrial and domestic wastes, septic tanks, leaking sewers, flood waters or other poor quality surface waters, mine waters, solids stored or spread at the surface, and even airborne wastes all have been sources of ground-water contamination in Michigan. In addition, naturally occurring saline waters have been induced into other aquifers by overpumping or unrestricted flow from artesian wells, possibly by dewatering operations, and by the deepening of surface stream channels. Vertical migration of saline waters through open holes from formations underlying various important aquifers also has spoiled some of the fresh ground waters in the State. In spite of the contamination that has occurred, however, the total amount of ground water that has been spoiled is only a small part of the total resource. Neither is the contamination so widespread as that of the surface streams of Michigan.Overall legal authority to control most types of ground-water contamination in the State has been assigned by the Michigan Legislature to the Water Resources Commission, although the Department of Conservation and the Health Department also exercise important water-pollution control functions. The Michigan Supreme Court, in an important case upholding the power

  14. Lake Michigan Wind Assessment Analysis, 2012 and 2013

    Directory of Open Access Journals (Sweden)

    Charles R Standridge

    2017-03-01

    Full Text Available A study was conducted to address the wind energy potential over Lake Michigan to support a commercial wind farm.  Lake Michigan is an inland sea in the upper mid-western United States.  A laser wind sensor mounted on a floating platform was located at the mid-lake plateau in 2012 and about 10.5 kilometers from the eastern shoreline near Muskegon Michigan in 2013.  Range gate heights for the laser wind sensor were centered at 75, 90, 105, 125, 150, and 175 meters.  Wind speed and direction were measured once each second and aggregated into 10 minute averages.  The two sample t-test and the paired-t method were used to perform the analysis.  Average wind speed stopped increasing between 105 m and 150 m depending on location.  Thus, the collected data is inconsistent with the idea that average wind speed increases with height. This result implies that measuring wind speed at wind turbine hub height is essential as opposed to using the wind energy power law to project the wind speed from lower heights.  Average speed at the mid-lake plateau is no more that 10% greater than at the location near Muskegon.  Thus, it may be possible to harvest much of the available wind energy at a lower height and closer to the shoreline than previously thought.  At both locations, the predominate wind direction is from the south-southwest.  The ability of the laser wind sensor to measure wind speed appears to be affected by a lack of particulate matter at greater heights.   Keywords: wind assessment, Lake Michigan, LIDAR wind sensor, statistical analysis. Article History: Received June 15th 2016; Received in revised form January 16th 2017; Accepted February 2nd 2017 Available online How to Cite This Article: Standridge, C., Zeitler, D., Clark, A., Spoelma, T., Nordman, E., Boezaart, T.A., Edmonson, J.,  Howe, G., Meadows, G., Cotel, A. and Marsik, F. (2017 Lake Michigan Wind Assessment Analysis, 2012 and 2013. Int. Journal of Renewable Energy Development

  15. 76 FR 56635 - Tuberculosis in Cattle and Bison; State and Zone Designations; Michigan

    Science.gov (United States)

    2011-09-14

    ... second zone, which is classified as modified accredited, comprises Alcona, Alpena, Montmorency, Oscoda...) A zone in Michigan that comprises Alcona, Alpena, Montmorency, and Oscoda Counties. * * * * * [[Page...

  16. MT-ADRES: Multithreading on Coarse-Grained Reconfigurable Architecture

    DEFF Research Database (Denmark)

    Wu, Kehuai; Kanstein, Andreas; Madsen, Jan

    2007-01-01

    The coarse-grained reconfigurable architecture ADRES (Architecture for Dynamically Reconfigurable Embedded Systems) and its compiler offer high instruction-level parallelism (ILP) to applications by means of a sparsely interconnected array of functional units and register files. As high-ILP archi......The coarse-grained reconfigurable architecture ADRES (Architecture for Dynamically Reconfigurable Embedded Systems) and its compiler offer high instruction-level parallelism (ILP) to applications by means of a sparsely interconnected array of functional units and register files. As high......-ILP architectures achieve only low parallelism when executing partially sequential code segments, which is also known as Amdahl’s law, this paper proposes to extend ADRES to MT-ADRES (Multi-Threaded ADRES) to also exploit thread-level parallelism. On MT-ADRES architectures, the array can be partitioned in multiple...

  17. 77 FR 41939 - Proposed Establishment of Class E Airspace; Deer Lodge, MT

    Science.gov (United States)

    2012-07-17

    ...-0379; Airspace Docket No. 12-ANM-7 Proposed Establishment of Class E Airspace; Deer Lodge, MT AGENCY... action proposes to establish Class E airspace at Deer Lodge-City-County Airport, Deer Lodge, MT... System (GPS) standard instrument approach procedures at Deer Lodge-City-County Airport, Deer Lodge, MT...

  18. Nuclear-like Seq in mt Genome - RMG | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available ar-like Seq in mt Genome Data detail Data name Nuclear-like Seq in mt Genome DOI 10...e Site Policy | Contact Us Nuclear-like Seq in mt Genome - RMG | LSDB Archive ... ...switchLanguage; BLAST Search Image Search Home About Archive Update History Data List Contact us RMG Nucle

  19. Exchangeable cations in some soils of Mt. Stara planina

    Directory of Open Access Journals (Sweden)

    Belanović Snežana

    2005-01-01

    Full Text Available Land use in forest and pasture ecosystems requires the respecting of ecological and economic interactions between the individual components of these ecosystems. The content of nutrition elements in the soil solution depends on soil types, climate conditions and vegetation species, i.e., it is conditioned by their cycling in the ecosystem. This paper studies the cation exchange capacity in pasture and forest soils of Mt. Stara Planina.

  20. MT survey in the Minaminoshiro oil field; Minaminoshiro chiiki ni okeru MT ho ni yoru sekiyu tanko (sanjigen MT ho chosa no kento). 1

    Energy Technology Data Exchange (ETDEWEB)

    Matsuo, K; Minegishi, M [Japan National Oil Corp., Tokyo (Japan). Technology Research Center

    1997-10-22

    Preliminary experiment, investigation, and study are conducted prior to an experimental 3-D MT (magnetotelluric) survey planned to be carried out in the Minaminoshiro district, Akita Prefecture. In the preliminary investigation, MT measurements were performed at nine locations. It was anticipated that national highways, waste treatment plants, high-voltage power lines, and railways in presence in the district would act as noise sources. Although the impact of such noise was detected in the single site treatment result, yet it was found that it would be mostly eliminated by use of the remote reference treatment. It was learned that the resistivity structure in this district was quite low in contrast or 1 ohm/m against 30 ohm/m, but the result of 3-D model calculation indicated that a sufficient analysis would be possible even in such a low contrast case. Furthermore, as the result of the study of the density of observation stations in the magnetic field, it was found that changes in the response of magnetic field to the resistivity structure would be approximately 2% at the maximum and that the ill effect on the result of measurement would be of the negligible magnitude even when a single magnetic field observation station is deployed against plural electric field observation stations. 6 refs., 7 figs.

  1. b-value distribution in and around Mt. Tarumae, Japan

    Science.gov (United States)

    Chiba, K.

    2017-12-01

    Mt. Tarumae is an active volcano located in southeastern Shikotsu caldera, Hokkaido, Japan. Recently, crustal expansion occurred in 1999-2000 and 2013 near the summit of Mt. Tarumae, with a M5.6 earthquake recorded west of the summit on 8 July 2014. In this study, I determined hypocenter distributions and then performed b-value analysis for the period between 1 August 2014 and 12 August 2016 to improve our understanding of the magma system geometry beneath the summit of Mt. Tarumae. Hypocenters are mainly distributed in two regions: 3 - 5 km west of Mt. Tarumae, and beneath the volcano. I then determined b-value distributions. Regions with relatively high b-values ( 1.3) are located at depths of -0.5 to 2.0 km beneath the summit and at depths greater than 6.0 km in the northwestern part at about 1.5 - 3.0 km from the summit, while a region with relatively low b-values ( 0.6) is located at depths of 2.0 - 6.0 km beneath the summit. Compared the b-value distributions with other geophysical observations, it was found that the high b-value region from -0.5 to 2.0 km depth corresponds to regions of lower resistivity, positive self-potential anomaly, and an inflation source observed in 1999-2000. It is thus inferred that this region is generated by crustal heterogeneity, a decrease in effective normal stress, and change of a frictional property due to the development of faults and fissures, and the circulation of hydrothermal fluids. On the other hand, the inflation source observed in 2013 was located near the boundary between the low b-value region beneath the summit and the deeper high b-value region in the northwestern part at about 1.5 - 3.0 km from the summit. Studies of other volcanoes suggest that such a high-b-value region likely corresponds to a magma chamber. From the deeper high b-value region estimated in this study, I am able to point out that the magma chamber is located to depths greater than 6.0 km in the northwestern part at about 1.5 - 3.0 km from the

  2. Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration

    DEFF Research Database (Denmark)

    Anilkumar, Narayanapanicker; Uekita, Takamasa; Couchman, John R

    2005-01-01

    of the palmitoylated cysteine relative to LLY573, a motif that interacts with mu2 subunit of adaptor protein 2, is critical for the cell motility-promoting activity of MT1-MMP and its clathrin-mediated internalization. Taken together, palmitoylation of MT1-MMP is one of the key posttranslational modifications......MT1-MMP is a type I transmembrane proteinase that promotes cell migration and invasion. Here, we report that MT1-MMP is palmitoylated at Cys574 in the cytoplasmic domain, and this lipid modification is critical for its promotion of cell migration and clathrin-mediated internalization...... that determines MT1-MMP-dependent cell migration....

  3. The Mitochondrial DNA (mtDNA)-Associated Protein SWIB5 Influences mtDNA Architecture and Homologous Recombination

    KAUST Repository

    Blomme, Jonas

    2017-04-19

    In addition to the nucleus, mitochondria and chloroplasts in plant cells also contain genomes. Efficient DNA repair pathways are crucial in these organelles to fix damage resulting from endogenous and exogenous factors. Plant organellar genomes are complex compared with their animal counterparts, and although several plant-specific mediators of organelle DNA repair have been reported, many regulators remain to be identified. Here, we show that a mitochondrial SWI/SNF (nucleosome remodeling) complex B protein, SWIB5, is capable of associating with mitochondrial DNA (mtDNA) in Arabidopsis thaliana. Gainand loss-of-function mutants provided evidence for a role of SWIB5 in influencing mtDNA architecture and homologous recombination at specific intermediate-sized repeats both under normal and genotoxic conditions. SWIB5 interacts with other mitochondrial SWIB proteins. Gene expression and mutant phenotypic analysis of SWIB5 and SWIB family members suggests a link between organellar genome maintenance and cell proliferation. Taken together, our work presents a protein family that influences mtDNA architecture and homologous recombination in plants and suggests a link between organelle functioning and plant development.

  4. Remote reference processing in MT survey using GPS clock; MT ho ni okeru GPS wo mochiita jikoku doki system

    Energy Technology Data Exchange (ETDEWEB)

    Yamane, K; Inoue, J; Takasugi, S [Geothermal Energy Research and Development Co. Ltd., Tokyo (Japan); Kosuge, S [DRICO Co. Ltd., Tokyo (Japan)

    1996-05-01

    A report is given about the application of a synchronizing system using clock signals from GPS satellites to a remote reference method which is a technique to reject noise from the MT method. This system uses the C/A code out of the L1 band waves from NAVSTAR/GPS satellites. The new system was operated in MT method-using investigations conducted at China Peninsula, Aichi Prefecture, and Izu Peninsula, Shizuoka Prefecture, with the reference points placed several 100km away in Iwate Prefecture on both occasions. It was found as the result that it is basically possible to catch signals from the GPS at any place, that the signals are accurate enough to be applied to time synchronization for the MT method, and that the signals assure a far remote reference method with a separation of several 100km between the sites involved. The referencing process at high frequencies whose feasibility had been doubted proved a success when highly correlated signals were exchanged between two stations over a distance of several 100km. 5 refs., 9 figs.

  5. 75 FR 26094 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago...

    Science.gov (United States)

    2010-05-11

    ...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... establishing a temporary safety zone from Brandon Road Lock and Dam to Lake Michigan. This temporary safety...

  6. Injectable-antineoplastic-drug practices in Michigan hospitals.

    Science.gov (United States)

    Cohen, I A; Newland, S J; Kirking, D M

    1987-05-01

    Practices related to parenteral (injectable) antineoplastic drugs (PADs) in Michigan hospitals were surveyed. All hospitals in Michigan were surveyed to assess compliance with American Society of Hospital Pharmacists (ASHP) and Occupational Safety and Health Administration (OSHA) recommendations related to PADs. Other PAD-related practice issues not covered within those guidelines were also studied. Surveys were mailed to the pharmacy directors of the state's 192 acute-care hospitals. Included were questions concerning policies and procedures for ordering, storing, preparing, handling, labeling, transporting, administering, and disposing of PADs. Questions concerning staff education, spill cleanup, and personnel issues were also included. A total of 169 questionnaires were returned, yielding a response rate of 88%. Of those respondents, 132 indicated that they prepare PAD doses for inpatients. Adherence rates were high for several of the PAD-preparation recommendations, including handwashing (97%) and gloving (98.5%). Rates for gowning (71.2%), labeling of PAD doses as biohazards (chemical hazards) (73.5%), and use of Class II biological-safety cabinets (71.2%) were less favorable. Practice areas with relatively poor adherence rates included use of plastic-backed absorbent pads under PAD preparation areas (53.8%), storing PADs separately from other drugs (48.5%), informing prospective employees of potential risks of handling PADs (36.4%), availability of spill kits (36.4%), and attaching and priming i.v. tubing before adding PADs to i.v. containers (5.4%). Many pharmacy departments in Michigan hospitals can substantially improve their adherence to ASHP and OSHA recommendations related to PADs.

  7. Estimation of alewife biomass in Lake Michigan, 1967-1978

    Science.gov (United States)

    Hatch, Richard W.; Haack, Paul M.; Brown, Edward H.

    1981-01-01

    The buildup of salmonid populations in Lake Michigan through annual stockings of hatchery-reared fish may become limited by the quantity of forage fish, mainly alewives Alosa pseudoharengus, available for food. As a part of a continuing examination of salmonid predator-prey relations in Lake Michigan, we traced changes in alewife biomass estimated from bottom-trawl surveys conducted in late October and early November 1967–1978. Weight of adult alewives trawled per 0.5 hectare of bottom (10-minute drag) at 16 depths along eight transects between 1973 and 1977 formed a skewed distribution: 72 of 464 drags caught no alewives; 89 drags caught less than 1 kg; and 2 drags caught more than 100 kg (maximum 159 kg). Analysis of variance in normalized catch per tow indicated highly significant differences between the main effects of years and depths, and highly significant differences in the interactions of years and transects, years and depths, and transects and depths. Five geographic and depth strata, formed by combining parts of transects wherein mean catch rate did not differ significantly, were the basis for calculating annual estimates of adult alewife biomass (with 90% confidence intervals). Estimated biomass of alewives (±90% confidence limits) in Lake Michigan proper (Green Bay and Grand Traverse Bay excluded) rose gradually from 46,000 (±9,000) t in 1967 to 114,000 (±17,000) t in 1973, declined to 45,000 (±8,000) t in 1977, and rose to 77,000 (±19,000) t in 1978.

  8. Whistler mode startup in the Michigan Mirror Machine

    International Nuclear Information System (INIS)

    Booske, J.; Getty, W.D.; Gilgenbach, R.M.; Goodman, T.; Whaley, D.; Olivieri, R.; Pitcher, E.; Simonetti, L.

    1985-01-01

    Results of investigations of whistler mode ECRH plasma startup in the Michigan Mirror Machine are presented. Electron-velocity-distribution and plasma-spatial-distribution time evolution are characterized by measurements from axially and radially moveable Langmuir probes, an endloss current detector, an electron cyclotron emission radiometer, a foil-filtered X-ray detector, and a diamagnetic loop at the mirror midplane. Measurements of the buildup of both electron density and perpendicular pressure (nkT/sub perpendicular/) are compared to predictions from various numerical models. Both modeling and data suggest the creation of a highly anisotropic electron velocity distribution function with a ''sloshing electron'' axial density profile

  9. Comparison between polluted and clean air masses over Lake Michigan

    International Nuclear Information System (INIS)

    Alkezweeny, A.J.; Laulainen, N.S.

    1981-01-01

    Clean and polluted air masses, advected over Lake Michigan, were studied using instrumental aircraft during the summers of 1976 and 1978. The results show that regardless of the degree of pollution, the particle size distribution is bimodal. The concentrations of sulfate, nitrate and trace metals in a clean air mass are more than an order of magnitude lower than those in polluted air masses. Furthermore, these concentrations are comparable with those measured in remote areas of the world. In clean air the ratio of the total light scattering to Rayleigh scattering is very close to one, indicating very low concentrations of particulates in the optically active size classes

  10. History of the Trenton Albion-Scipio trend of Michigan

    Energy Technology Data Exchange (ETDEWEB)

    Beghini, V G; Conroy, T R

    1966-01-01

    This discussion of the history of the Trenton Albion-Scipio trend in Michigan includes the location and development history, geology and reservoir characteristics, drilling and completion methods, production and history of both the Albion and Scipio Fields, production operation, and workover procedure. Maps, illustrations, and graphs of the topics discussed are included. The largest drilling problem encountered was lost circulation causing several blowouts, 2 of which resulted in spectacular fires. Production problems include paraffin deposition, corrosion and brine disposal. Well workovers have been performed in an attempt to correct one or more of 3 problems--high gas- oil ratio, high water cut, and low capacity.

  11. Neutron radiography at the University of Michigan's Phoenix Memorial Laboratory

    International Nuclear Information System (INIS)

    Lindsay, J.T.; Elam, S.; Koblish, T.; Lee, P.; McAuliffe, D.

    1990-01-01

    Real-time neutron radiography (RTNR) is rapidly becoming a valuable tool for nondestructive testing and basic research with a wide variety of applications. The Phoenix Memorial Laboratory (PML) at the University of Michigan has developed an RTNR facility and has been using this facility to study several phenomena of interest to researchers in many areas. These phenomena include imaging of the internal fluid flow in gas turbine engine nozzles and coking and debris deposition in several gas turbine nozzles. This paper presents a summary of the technique and facilities involved in these applications

  12. Surveillance for work-related skull fractures in Michigan.

    Science.gov (United States)

    Kica, Joanna; Rosenman, Kenneth D

    2014-12-01

    The objective was to develop a multisource surveillance system for work-related skull fractures. Records on work-related skull fractures were obtained from Michigan's 134 hospitals, Michigan's Workers' Compensation Agency and death certificates. Cases from the three sources were matched to eliminate duplicates from more than one source. Workplaces where the most severe injuries occurred were referred to OSHA for an enforcement inspection. There were 318 work related skull fractures, not including facial fractures, between 2010 and 2012. In 2012, after the inclusion of facial fractures, 316 fractures were identified of which 218 (69%) were facial fractures. The Bureau of Labor Statistic's (BLS) 2012 estimate of skull fractures in Michigan, which includes facial fractures, was 170, which was 53.8% of those identified from our review of medical records. The inclusion of facial fractures in the surveillance system increased the percentage of women identified from 15.4% to 31.2%, decreased severity (hospitalization went from 48.7% to 10.6% and loss of consciousness went from 56.5% to 17.8%), decreased falls from 48.2% to 27.6%, and increased assaults from 5.0% to 20.2%, shifted the most common industry from construction (13.3%) to health care and social assistance (15.0%) and the highest incidence rate from males 65+ (6.8 per 100,000) to young men, 20-24 years (9.6 per 100,000). Workplace inspections resulted in 45 violations and $62,750 in penalties. The Michigan multisource surveillance system of workplace injuries had two major advantages over the existing national system: (a) workplace investigations were initiated hazards identified and safety changes implemented at the facilities where the injuries occurred; and (b) a more accurate count was derived, with 86% more work-related skull fractures identified than BLS's employer based estimate. A more comprehensive system to identify and target interventions for workplace injuries was implemented using hospital and

  13. 76 FR 48751 - Security Zones; Captain of the Port Lake Michigan Zone

    Science.gov (United States)

    2011-08-09

    ... Jardine Water Filtration Plant security zone would encompass all U.S. navigable waters of Lake Michigan... areas near shore to Chicago's water filtration plants; the security zones have been designed to allow.... 165.910 Security Zones; Captain of the Port Lake Michigan. (a) * * * (1) Jardine Water Filtration...

  14. 76 FR 80392 - Notice of Inventory Completion: University of Michigan Museum of Anthropology, Ann Arbor, MI

    Science.gov (United States)

    2011-12-23

    ...: University of Michigan Museum of Anthropology, Ann Arbor, MI AGENCY: National Park Service, Interior. ACTION... Michigan officials and its Museum of Anthropology professional staff in consultation with representatives... accessioned into the Museum of Anthropology. Between 2007 and 2009 the remains were inventoried at the...

  15. 78 FR 34129 - Notice of Intent To Repatriate Cultural Items: University of Michigan, Museum of Anthropology...

    Science.gov (United States)

    2013-06-06

    ... DEPARTMENT OF THE INTERIOR National Park Service [NPS-WASO-NAGPRA-13042; PPWOCRADN0-PCU00RP14.R50000] Notice of Intent To Repatriate Cultural Items: University of Michigan, Museum of Anthropology... County, MI. In 1924, these items were sold to the University of Michigan, Museum of Anthropology, by Rev...

  16. Forging New Pathways: The Impact of the Breaking through Initiative in Michigan

    Science.gov (United States)

    Schanker, Jennifer B.; Taylor, Judith C.

    2012-01-01

    The Michigan Center for Student Success commissioned this study to determine whether strategies employed to improve adult students' success at 41 Breaking Through colleges nationwide have taken root at Michigan's original colleges and spread beyond them. A statewide survey revisited four of the colleges profiled in previous publications, and the…

  17. Forging New Pathways: The Impact of the Breaking through Initiative in Michigan. Executive Summary

    Science.gov (United States)

    Schanker, Jennifer B.; Taylor, Judith C.

    2012-01-01

    The Michigan Center for Student Success commissioned this study to determine whether strategies employed to improve adult students' success at 41 Breaking Through colleges nationwide have taken root at Michigan's original colleges and spread beyond them. A statewide survey revisited four of the colleges profiled in previous publications, and the…

  18. The Michigan high-level radioactive waste program: Final technical progress report

    International Nuclear Information System (INIS)

    1987-01-01

    This report comprises the state of Michigan's final technical report on the location of a proposed high-level radioactive waste disposal site. Included are a list of Michigan's efforts to review the DOE proposal and a detailed report on the application of geographic information systems analysis techniques to the review process

  19. 78 FR 65382 - Notice of Inventory Completion: University of Michigan, Ann Arbor, MI

    Science.gov (United States)

    2013-10-31

    ....S.C. 3003, of the completion of an inventory of human remains under the control of the University of....R50000] Notice of Inventory Completion: University of Michigan, Ann Arbor, MI AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The University of Michigan has completed an inventory of human...

  20. 78 FR 65369 - Notice of Inventory Completion: University of Michigan, Ann Arbor, MI

    Science.gov (United States)

    2013-10-31

    ....S.C. 3003, of the completion of an inventory of human remains under the control of the University of....R50000] Notice of Inventory Completion: University of Michigan, Ann Arbor, MI AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The University of Michigan has completed an inventory of human...

  1. 78 FR 65366 - Notice of Inventory Completion: University of Michigan, Ann Arbor, MI

    Science.gov (United States)

    2013-10-31

    ....S.C. 3003, of the completion of an inventory of human remains under the control of the University of....R50000] Notice of Inventory Completion: University of Michigan, Ann Arbor, MI AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The University of Michigan has completed an inventory of human...

  2. Factors Influencing School Closure and Dismissal Decisions: Influenza A (H1N1), Michigan 2009

    Science.gov (United States)

    Dooyema, Carrie A.; Copeland, Daphne; Sinclair, Julie R.; Shi, Jianrong; Wilkins, Melinda; Wells, Eden; Collins, Jim

    2014-01-01

    Background: In fall 2009, many US communities experienced school closures during the influenza A H1N1 pandemic (pH1N1) and the state of Michigan reported 567 closures. We conducted an investigation in Michigan to describe pH1N1-related school policies, practices, and identify factors related to school closures. Methods: We distributed an online…

  3. Michigan State University Extension Educators' Perceptions of the Use of Digital Technology in Their Work

    Science.gov (United States)

    Wells, Elizabeth Chase

    2009-01-01

    This research study examined Michigan State University Extension educators' perceptions of the use of digital technology in their work. It used a mixed method of research which included a mailed survey and interviews of selected respondents. A census survey using Dillman's Total Design method was sent to 290 field staff of Michigan State…

  4. Lake Michigan lake trout PCB model forecast post audit (oral presentation)

    Science.gov (United States)

    Scenario forecasts for total PCBs in Lake Michigan (LM) lake trout were conducted using the linked LM2-Toxics and LM Food Chain models, supported by a suite of additional LM models. Efforts were conducted under the Lake Michigan Mass Balance Study and the post audit represents an...

  5. High Energy Theory Workshops and Visitors at the Michigan Center for Theoretical Physics FY16

    Energy Technology Data Exchange (ETDEWEB)

    Pierce, Aaron [Univ. of Michigan, Ann Arbor, MI (United States)

    2017-08-04

    This award provided partial support for the Michigan Center for Theoretical Physics to host two workshops "Beyond the Standard Model 2016" in October 2016, and the "5th MCTP Symposium: Foundations of String Cosmology" in April 2017 on the University of Michigan campus.

  6. First report of Streptomyces stelliscabiei causing potato common scab in Michigan

    Science.gov (United States)

    Streptomyces scabies has been reported as the predominant cause of potato scab in Michigan. In a 2007 survey of common scab in Michigan, however, isolates were collected from a field that did not fit the description for S. scabies. Tests using species-specific PCR primers indicated isolates were S. ...

  7. 78 FR 18336 - Public Water System Supervision Program Approval for the State of Michigan

    Science.gov (United States)

    2013-03-26

    ... and Copper Rule Short Term Revisions, and the Lead and Copper Rule Minor Revisions. These rules better... defined in 18 U.S.C. 1151. By approving these rules, EPA does not intend to affect the rights of federally recognized Indian Tribes in Michigan, nor does it intend to limit existing rights of the State of Michigan...

  8. Improving Michigan STEM Teachers and Teaching: The W.K. Kellogg Foundation's Woodrow Wilson Teaching Fellowship

    Science.gov (United States)

    Woodrow Wilson National Fellowship Foundation, 2016

    2016-01-01

    The W. K. Kellogg Foundation's Woodrow Wilson Michigan Teaching Fellowship successfully addressed the challenge of preparing and supporting effective teachers for Michigan's high-need classrooms, while helping transform teacher education across the state for the long term. This report analyzes the efforts of the W. K. Kellogg Foundation's Woodrow…

  9. Population increase in Kirtland's warbler and summer range expansion to Wisconsin and Michigan's Upper Peninsula, USA

    Science.gov (United States)

    John R. Probst; Deahn Donner; Carol I. Bocetti; Steve Sjogren

    2003-01-01

    The threatened Kirtland`s warbler Dendroica kirtlandii breeds in stands of young jack pine Pinus banksiana growing on well-drained soils in Michigan, USA. We summarize information documenting the range expansion of Kirtland`s warbler due to increased habitat management in the core breeding range in the Lower Peninsula of Michigan...

  10. Maintenance Dredging of the Federal Navigation Channels in the Saginaw River and Saginaw Bay, Michigan.

    Science.gov (United States)

    1975-12-01

    contact is Dr. Martha Bigelow, Director, Michigan History Division, Depar=int of State, Lansing, Michigan 48918. Te National Recister shoeuld also be...other low growth. Methylation - Change from an inorganic to an organic form usually as a result of bacterial action. For * example, the metal mercury

  11. 75 FR 32664 - Safety Zone; Milwaukee Air and Water Show, Lake Michigan, Milwaukee, WI

    Science.gov (United States)

    2010-06-09

    .... ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a safety zone on Lake Michigan... of Lake Michigan due to a large-scale air show and a fireworks display. This temporary safety zone is... air show and fireworks display. DATES: This regulation is effective from 12:01 a.m. on June 10, 2010...

  12. Job-Embedded Professional Development Policy in Michigan: Can It Be Successful?

    Science.gov (United States)

    Owens, Michael A.; Pogodzinski, Ben; Hill, William E.

    2016-01-01

    This paper evaluates Michigan's recently implemented job-embedded professional development policy using criteria of relevance, focus, goal orientation and social scope. The authors assert that while Michigan's policy does address all four criteria detailing effective professional development, there are limitations in the policy that may impact the…

  13. 76 FR 63202 - Security Zones; Captain of the Port Lake Michigan Zone

    Science.gov (United States)

    2011-10-12

    ..., SE., Washington, DC 20590, between 9 a.m. and 5 p.m., Monday through Friday, except Federal holidays... Filtration Plant security zone will encompass all U.S. navigable waters of Lake Michigan within an arc of a..., Illinois. It encompasses all U.S. navigable waters of Lake Michigan within the arc of a circle with a 100...

  14. Results of photochemical modeling sensitivity analyses in the Lake Michigan region: Current status of Lake Michigan Ozone Control Program (LMOP) modeling

    Energy Technology Data Exchange (ETDEWEB)

    Dolwick, P.D. [Lake Michigan Air Directors Consortium, Des Plaines, IL (United States); Kaleel, R.J. [Illinois Environmental Protection Agency, Springfield, IL (United States); Majewski, M.A. [Wisconsin Dept. of Natural Resources, Madison, WI (United States)

    1994-12-31

    The four states that border Lake Michigan are cooperatively applying a state-of-the-art nested photochemical grid model to assess the effects of potential emission control strategies on reducing elevated tropospheric ozone concentrations in the region to levels below the national ambient air quality standard. In order to provide an extensive database to support the application of the photochemical model, a substantial data collection effort known as the Lake Michigan Ozone Study (LMOS) was completed during the summer of 1991. The Lake Michigan Ozone Control Program (LMOP) was established by the States of Illinois, Wisconsin, Michigan, and Indiana to carry out the application of the modeling system developed from the LMOS, in terms of developing the attainment demonstrations required from this area by the Clean Air Act Amendments of 1990.

  15. A reduced number of mtSNPs saturates mitochondrial DNA haplotype diversity of worldwide population groups.

    Science.gov (United States)

    Salas, Antonio; Amigo, Jorge

    2010-05-03

    The high levels of variation characterising the mitochondrial DNA (mtDNA) molecule are due ultimately to its high average mutation rate; moreover, mtDNA variation is deeply structured in different populations and ethnic groups. There is growing interest in selecting a reduced number of mtDNA single nucleotide polymorphisms (mtSNPs) that account for the maximum level of discrimination power in a given population. Applications of the selected mtSNP panel range from anthropologic and medical studies to forensic genetic casework. This study proposes a new simulation-based method that explores the ability of different mtSNP panels to yield the maximum levels of discrimination power. The method explores subsets of mtSNPs of different sizes randomly chosen from a preselected panel of mtSNPs based on frequency. More than 2,000 complete genomes representing three main continental human population groups (Africa, Europe, and Asia) and two admixed populations ("African-Americans" and "Hispanics") were collected from GenBank and the literature, and were used as training sets. Haplotype diversity was measured for each combination of mtSNP and compared with existing mtSNP panels available in the literature. The data indicates that only a reduced number of mtSNPs ranging from six to 22 are needed to account for 95% of the maximum haplotype diversity of a given population sample. However, only a small proportion of the best mtSNPs are shared between populations, indicating that there is not a perfect set of "universal" mtSNPs suitable for all population contexts. The discrimination power provided by these mtSNPs is much higher than the power of the mtSNP panels proposed in the literature to date. Some mtSNP combinations also yield high diversity values in admixed populations. The proposed computational approach for exploring combinations of mtSNPs that optimise the discrimination power of a given set of mtSNPs is more efficient than previous empirical approaches. In contrast to

  16. 76 FR 44947 - Notice of Intent To Repatriate Cultural Items: University of Michigan Museum of Anthropology, Ann...

    Science.gov (United States)

    2011-07-27

    ... Cultural Items: University of Michigan Museum of Anthropology, Ann Arbor, MI AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The University of Michigan Museum of Anthropology, in consultation with... contact the University of Michigan Museum of Anthropology. DATES: Representatives of any Indian tribe that...

  17. 78 FR 17099 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago...

    Science.gov (United States)

    2013-03-20

    ...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... Guard will enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including...

  18. 78 FR 49684 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2013-08-15

    ...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago... the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago...

  19. 77 FR 20295 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago...

    Science.gov (United States)

    2012-04-04

    ... Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines...

  20. 78 FR 65874 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2013-11-04

    ...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago... the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... Guard will enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including...

  1. 75 FR 73966 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2010-11-30

    ... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines...

  2. 76 FR 23524 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2011-04-27

    ...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago... safety zone from Brandon Road Lock and Dam to Lake Michigan. This proposed safety zone will cover 77.... This TIR established a 77 mile long safety zone from Brandon Road Lock to Lake Michigan in Chicago, IL...

  3. 78 FR 4071 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2013-01-18

    ...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago... the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... Coast Guard will enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan...

  4. 78 FR 36091 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2013-06-17

    ... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago...

  5. 77 FR 35854 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2012-06-15

    ... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines...

  6. 75 FR 64673 - Safety Zone, Brandon Road Lock and, Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2010-10-20

    ... Zone, Brandon Road Lock and, Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and... Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Ship and...: The Coast Guard will enforce Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des...

  7. 78 FR 40635 - Safety Zone; Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2013-07-08

    ... Zone; Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... Coast Guard will enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan...

  8. 78 FR 36092 - Safety Zone; Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2013-06-17

    ... Zone; Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... Coast Guard will enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan...

  9. 77 FR 65478 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago...

    Science.gov (United States)

    2012-10-29

    ...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River...

  10. 76 FR 63199 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2011-10-12

    ... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal...

  11. 76 FR 2829 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2011-01-18

    ... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines...

  12. 75 FR 64147 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2010-10-19

    ... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Ship and Sanitary Canal... . SUPPLEMENTARY INFORMATION: The Coast Guard will enforce Safety Zone, Brandon Road Lock and Dam to Lake Michigan...

  13. 75 FR 52462 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2010-08-26

    ... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines...

  14. 77 FR 60044 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2012-10-02

    ...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago... the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River...

  15. Uranium and thorium occurrences in Precambrian rocks, Upper Peninsula of Michigan and northern Wisconsin, with thoughts on other possible settings

    International Nuclear Information System (INIS)

    Kalliokoski, J.

    1976-01-01

    The following areas are covered: Precambrian geology of northern Michigan; mode of occurrence of uranium and thorium in the Precambrian rocks of the Upper Peninsula of Michigan; selected stratigraphic relationships, Precambrian rocks of Michigan; mode of occurrence of uranium and thorium in Precambrian rocks of Wisconsin; and background data for geochemical exploration

  16. Mt. Elgon, Africa, Shaded Relief and Colored Height

    Science.gov (United States)

    2004-01-01

    The striking contrast of geologic structures in Africa is shown in this shaded relief image of Mt. Elgon on the left and a section of the Great Rift Valley on the right. Mt. Elgon is a solitary extinct volcano straddling the border between Uganda and Kenya, and at 4,321 meters (14,178 feet) tall is the eighth highest mountain in Africa. It is positioned on the Pre-Cambriam bedrock of the Trans Nzoia Plateau, and is similar to other such volcanoes in East Africa in that it is associated with the formation of the Rift Valley. However one thing that sets Mt. Elgon apart is its age. Although there is no verifiable evidence of its earliest volcanic activity, Mt. Elgon is estimated to be at least 24 million years old, making it the oldest extinct volcano in East Africa. This presents a striking comparison to Mt. Kilimanjaro, the highest mountain in Africa at 5,895 meters (19,341 feet), which is just over one million years old. Judging by the diameter of its base, it is a common belief among geological experts that Mt. Elgon was once the highest mountains in Africa, however erosion has played a significant role in reducing the height to its present value. Juxtaposed with this impressive mountain is a section of the Great Rift Valley, a geological fault system that extends for about 4,830 kilometers (2,995 miles) from Syria to central Mozambique. Erosion has concealed some sections, but in some sections like that shown here, there are sheer cliffs several thousand feet high. The present configuration of the valley, which dates from the mid-Pleistocene epoch, results from a rifting process associated with thermal currents in the Earth's mantle. Two visualization methods were combined to produce the image: shading and color coding of topographic height. The shade image was derived by computing topographic slope in the northwest-southeast direction, so that northwest slopes appear bright and southeast slopes appear dark. Color coding is directly related to topographic height

  17. DNA Barcoding the Medusozoa using mtCOI

    Science.gov (United States)

    Ortman, Brian D.; Bucklin, Ann; Pagès, Francesc; Youngbluth, Marsh

    2010-12-01

    The Medusozoa are a clade within the Cnidaria comprising the classes Hydrozoa, Scyphozoa, and Cubozoa. Identification of medusozoan species is challenging, even for taxonomic experts, due to their fragile forms and complex, morphologically-distinct life history stages. In this study 231 sequences for a portion of the mitochondrial Cytochrome Oxidase I (mtCOI) gene were obtained from 95 species of Medusozoans including; 84 hydrozoans (61 siphonophores, eight anthomedusae, four leptomedusae, seven trachymedusae, and four narcomedusae), 10 scyphozoans (three coronatae, four semaeostomae, two rhizostomae, and one stauromedusae), and one cubozoan. This region of mtCOI has been used as a DNA barcode (i.e., a molecular character for species recognition and discrimination) for a diverse array of taxa, including some Cnidaria. Kimura 2-parameter (K2P) genetic distances between sequence variants within species ranged from 0 to 0.057 (mean 0.013). Within the 13 genera for which multiple species were available, K2P distance between congeneric species ranged from 0.056 to 0.381. A cluster diagram generated by Neighbor Joining (NJ) using K2P distances reliably clustered all barcodes of the same species with ≥99% bootstrap support, ensuring accurate identification of species. Intra- and inter-specific variation of the mtCOI gene for the Medusozoa are appropriate for this gene to be used as a DNA barcode for species-level identification, but not for phylogenetic analysis or taxonomic classification of unknown sequences at higher taxonomic levels. This study provides a set of molecular tools that can be used to address questions of speciation, biodiversity, life-history, and population boundaries in the Medusozoa.

  18. Spine growth mechanisms: friction and seismicity at Mt. Unzen, Japan

    Science.gov (United States)

    Hornby, Adrian; Kendrick, Jackie; Hirose, Takehiro; Henton De Angelis, Sarah; De Angelis, Silvio; Umakoshi, Kodo; Miwa, Takahiro; Wadsworth, Fabian; Dingwell, Don; Lavallee, Yan

    2014-05-01

    The final episode of dome growth during the 1991-1995 eruption of Mt. Unzen was characterised by spine extrusion accompanied by repetitive seismicity. This type of cyclic activity has been observed at several dome-building volcanoes and recent work suggests a source mechanism of brittle failure of magma in the conduit. Spine growth may proceed by densification and closure of permeable pathways within the uppermost conduit magma, leading to sealing of the dome and inflation of the edifice. Amplified stresses on the wall rock and plug cause brittle failure near the conduit wall once static friction forces are overcome, and during spine growth these fractures may propagate to the dome surface. The preservation of these features is rare, and the conduit is typically inaccessible; therefore spines, the extruded manifestation of upper conduit material, provide the opportunity to study direct evidence of brittle processes in the conduit. At Mt. Unzen the spine retains evidence for brittle deformation and slip, however mechanical constraints on the formation of these features and their potential impact on eruption dynamics have not been well constrained. Here, we conduct an investigation into the process of episodic spine growth using high velocity friction apparatus at variable shear slip rate (0.4-1.5 m.s-1) and normal stress (0.4-3.5 MPa) on dome rock from Mt. Unzen, generating frictional melt at velocity >0.4 m.s-1 and normal stress >0.7 MPa. Our results show that the presence of frictional melt causes a deviation from Byerlee's frictional rule for rock friction. Melt generation is a disequilibrium process: initial amphibole breakdown leads to melt formation, followed by chemical homogenization of the melt layer. Ultimately, the experimentally generated frictional melts have a similar final chemistry, thickness and comminuted clast size distribution, thereby facilitating the extrapolation of a single viscoelastic model to describe melt-lubricated slip events at Mt

  19. Mt. Apo geothermal project : a learning experience in sustainable development

    International Nuclear Information System (INIS)

    Ote, Leonardo M.; De Jesus, Agnes C.

    1997-01-01

    The Mt. Apo geothermal project, a critical component of the Philippine energy program met stiff opposition from 1988-1991. Seemingly unresolvable legal, environmental and cultural issues between the government developer, the Philippine National Oil Company-Energy Development Corporation (PNOC-EDC) and various affected sectors delayed the project for two years. The paper discusses the efforts undertaken by the developer to resolve these conflicts through a series of initiatives that transformed the project into a legally, environmentally and socially acceptable project. Lastly, the PNOC-EDC experience has evolved a new set of procedures for the environmental evaluation of development project in the Philippines. (author)

  20. Sidereal anisotropy of small air showers observed at Mt. Norikura

    International Nuclear Information System (INIS)

    Nagashima, K.; Sakakibara, S.; Fujimoto, K.; Fujii, Z.; Ueno, H.; Kondo, I.

    1977-01-01

    Observation of small air showers has been continued from August 1970, using a part of the multidirectional cosmic ray telescope at Mt. Norikura. Most significant result obtained from this observation was a sidereal diurnal anisotropy of amplitude 0.051 +- 0.004% with maximum at 1.0 +- 0.5 h, which showed a persistent trend over six years. Based on the results of the observation together with those obtained by Gombosi et al. and Fenton et al., a tentative model of sidereal anisotropies is presented. (author)

  1. Michigan dioxin exposure study: planning phase and protocol development

    Energy Technology Data Exchange (ETDEWEB)

    Adriaens, P. [Univ. of Michigan, Coll. of Engineering, Ann Arbor (United States); Garabrant, D.; Franzblau, A. [Univ. of Michigan, School for Public Health, Ann Arbor (United States); Gillespie, B. [Univ. of Michigan, Center for Statistics, Ann Arbor (United States); Lepowski, J. [Univ. of Michigan, Inst. for Social Research, Ann Arbor (United States)

    2004-09-15

    The University of Michigan has been commissioned to conduct one of the largest environmental epidemiology studies (700 residents) of dioxin exposure among the population of Michigan to describe the pattern of serum dioxin levels among adults and to understand the factors that explain variation in serum dioxin levels. The study is being undertaken (2004-2006) in response to concerns among the population of Midland and Saginaw Counties that dioxins from the Dow Chemical Company facilities in Midland have resulted in contamination of areas of the City of Midland and have contaminated the sediments in the Tittabawassee River flood plain. There is concern that body burdens of dioxins are elevated because of environmental contamination. The appropriate way to respond to these concerns is to measure the serum dioxin levels in a probability sample of the population in the region and to estimate each individual's past exposure to various factors that are believed to contribute to the body burden of dioxins. By measuring factors that reflect potential exposure to dioxins through air, water, soil, food intake, occupations, and various recreational activities, we can identify the factors that correlate with (and explain variation in) serum dioxin levels. The central goal of the study is to determine which factors explain variation in serum dioxin levels, and to quantify how much variation each factor explains. This paper provides information on the planning phase, study scope and objectives.

  2. Radiological survey results at 4400 Piehl Road, Ottawa Lake, Michigan

    International Nuclear Information System (INIS)

    Foley, R.D.; Johnson, C.A.

    1993-04-01

    At the request of the US Department of Energy (DOE), a team from Oak Ridge National Laboratory conducted a radiological survey at 4400 Piehl Road in Ottawa Lake, Michigan. The survey was performed in September, 1992. The purpose of the survey was to determine if materials containing uranium from work performed under government contract at the former Baker Brothers facility in Toledo, Ohio had been transported off-site to this neighboring area. The radiological survey included surface gamma scans indoors and outdoors, alpha and beta scans inside the house and attached garage, beta-gamma scans of the hard surfaces outside, and the collection of soil, water, and dust samples for radionuclide analyses. Results of the survey demonstrated that the majority of the measurements on the property were within DOE guidelines. However, the presence of isolated spots of uranium contamination were found in two areas where materials were allegedly transported to the property from the former Baker Brothers site. Uranium uptake by persons on the property by ingestion is fairly unlikely, but inhalation is a possibility. Based on these findings, it is recommended that the residential property at 4400 Piehl Road in Ottawa Lake, Michigan be considered for inclusion under FUSRAP

  3. Time-Varying Value of Energy Efficiency in Michigan

    Energy Technology Data Exchange (ETDEWEB)

    Mims, Natalie; Eckman, Tom; Schwartz, Lisa C.

    2018-04-02

    Quantifying the time-varying value of energy efficiency is necessary to properly account for all of its benefits and costs and to identify and implement efficiency resources that contribute to a low-cost, reliable electric system. Historically, most quantification of the benefits of efficiency has focused largely on the economic value of annual energy reduction. Due to the lack of statistically representative metered end-use load shape data in Michigan (i.e., the hourly or seasonal timing of electricity savings), the ability to confidently characterize the time-varying value of energy efficiency savings in the state, especially for weather-sensitive measures such as central air conditioning, is limited. Still, electric utilities in Michigan can take advantage of opportunities to incorporate the time-varying value of efficiency into their planning. For example, end-use load research and hourly valuation of efficiency savings can be used for a variety of electricity planning functions, including load forecasting, demand-side management and evaluation, capacity planning, long-term resource planning, renewable energy integration, assessing potential grid modernization investments, establishing rates and pricing, and customer service (KEMA 2012). In addition, accurately calculating the time-varying value of efficiency may help energy efficiency program administrators prioritize existing offerings, set incentive or rebate levels that reflect the full value of efficiency, and design new programs.

  4. Short-lived radionuclides program at the University of Michigan

    International Nuclear Information System (INIS)

    Wieland, D.M.

    1985-01-01

    The University of Michigan Nuclear Medicine Research Program, from instrumentation design through radiopharmaceutical development to clinical evaluation, is heavily dependent on the availability and use of iodine-123. Research activities at the University of Michigan can be divided into four major areas: instrumentation, radiochemistry, radiopharmaceutical development, and clinical evaluation. In the first category a new single-photon ring tomograph (SPRINT) has been built and is undergoing performance testing. SPRINT has been designed specifically for brain imaging with 123 I-labeled agents. In the area of radiochemistry, a simple radioiodide exchange technique has been developed for the rapid synthesis of 123 I-labeled aromatic compounds. In the radiopharmaceutical arena, a new agent, 123 I-meta-iodobenzyl-guanidine (MIBG), has been developed - the result of an extensive structure-distribution-relationship study. This radiopharmaceutical, a storage analog of norepinephrine, images organs with rich sympathetic innervation such as the heart and spleen. In the Nuclear Medicine Clinic three 123 I-labeled radiopharmaceuticals are undergoing evaluation

  5. Boom, Bust and Beyond: Arts and Sustainability in Calumet, Michigan

    Directory of Open Access Journals (Sweden)

    Richelle Winkler

    2016-03-01

    Full Text Available Cycles of boom and bust plague mining communities around the globe, and decades after the bust the skeletons of shrunken cities remain. This article evaluates strategies for how former mining communities cope and strive for sustainability in the decades well beyond the bust, using a case study of Calumet, Michigan. In 1910, Calumet was at the center of the mining industry in the Upper Peninsula of Michigan, but in the century since its peak, mining employment steadily declined until the last mine closed in 1968, and the population declined by over 80%. This paper explores challenges, opportunities, and progress toward sustainability associated with arts-related development in this context. Methods are mixed, including observation, interviews, document review, a survey, and secondary data analysis. We follow Flora and Flora’s Community Capitals Framework to analyze progress toward sustainability. Despite key challenges associated with the shrunken city context (degraded tax base, overbuilt and aging infrastructure, diminished human capital, and a rather limited set of volunteers and political actors, we find the shrunken city also offers advantages for arts development, including low rents, less risk of gentrification, access to space, and political incentive. In Calumet, we see evidence of a spiraling up pattern toward social sustainability resulting from arts development; however impacts on environmental and economic sustainability are limited.

  6. Food-induced reinforcement is abrogated by the genetic deletion of the MT1 or MT2 melatonin receptor in C3H/HeN mice.

    Science.gov (United States)

    Clough, Shannon J; Hudson, Randall L; Dubocovich, Margarita L

    2018-05-02

    Palatable food is known for its ability to enhance reinforcing responses. Studies have suggested a circadian variation in both drug and natural reinforcement, with each following its own time course. The goal of this study was to determine the role of the MT 1 and MT 2 melatonin receptors in palatable snack food-induced reinforcement, as measured by the conditioned place preference (CPP) paradigm during the light and dark phases. C3H/HeN wild-type mice were trained for snack food-induced CPP at either ZT 6 - 8 (ZT: Zeitgeber time; ZT 0 = lights on), when endogenous melatonin levels are low, or ZT 19 - 21, when melatonin levels are high. These time points also correspond to the high and low points for expression of the circadian gene Period1, respectively. The amount of snack food (chow, Cheetos®, Froot Loops® and Oreos®) consumed was of similar magnitude at both times, however only C3H/HeN mice conditioned to snack food at ZT 6 - 8 developed a place preference. C3H/HeN mice with a genetic deletion of either the MT 1 (MT 1 KO) or MT 2 (MT 2 KO) receptor tested at ZT 6 - 8 did not develop a place preference for snack food. Although the MT 2 KO mice showed a similar amount of snack food consumed when compared to wild-type mice, the MT 1 KO mice consumed significantly less than either genotype. We conclude that in our mouse model snack food-induced CPP is dependent on time of day and the presence of the MT 1 or MT 2 receptors, suggesting a role for melatonin and its receptors in snack food-induced reinforcement. Copyright © 2018 Elsevier B.V. All rights reserved.

  7. Expression of melatonin receptor MT1 in cells of human invasive ductal breast carcinoma.

    Science.gov (United States)

    Jablonska, Karolina; Pula, Bartosz; Zemla, Agata; Owczarek, Tomasz; Wojnar, Andrzej; Rys, Janusz; Ambicka, Aleksandra; Podhorska-Okolow, Marzena; Ugorski, Maciej; Dziegiel, Piotr

    2013-04-01

    In humans, two main types of membrane melatonin receptors have been identified, MT1 and MT2. Expression of MT1 in neoplastic cells seems to increase the efficacy of melatonin's oncostatic activity. The purpose of this study was to determine the distribution and the intensity of MT1 expression in breast cancer cells and to correlate it with clinicopathological factors. Immunohistochemical studies (IHC) were conducted on 190 cases of invasive ductal breast carcinomas (IDC) and molecular studies were performed on 29 cases of frozen tumor fragments and selected breast cancer cell lines. Most of the studied tumors manifested a membranous/cytoplasmic IHC expression of MT1. In IDC, the MT1 expression was higher than in fibrocystic breast disease. MT1 expression was higher in estrogen receptor positive (ER+) and HER2 positive (HER2+) tumors. Triple negative tumors (TN) manifested the lowest MT1 expression level. The lowest MT1 protein expression level was noted in the TN breast cancer cell line MDA-MB-231 compared with ER+ cell lines MCF-7 and SK-BR-3. MT1 mRNA expression was negatively correlated with the malignancy grade of the studied IDC cases. Moreover, higher MT1 expression was associated with patients' longer overall survival (OS) in the group of ER+ breast cancers and treated with tamoxifen. Multivariate analysis indicated that MT1 was an independent prognostic factor in the ER+ tumors for OS and event-free survival in the ER+ tumors. The results of this study may point to a potential prognostic and therapeutic significance of MT1 in IDC. © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.

  8. 78 FR 33047 - Humboldt-Toiyabe National Forest, Carson Ranger District Mt. Rose Ski Tahoe-Atoma Area...

    Science.gov (United States)

    2013-06-03

    ... Mt. Rose Ski Tahoe--Atoma Area Environmental Impact Statement AGENCY: Forest Service, USDA. ACTION... the effects of a proposal from Mt. Rose Ski Tahoe (Mt. Rose) to expand its lift and terrain network. The project is located approximately 12 miles west of the intersection of Mt. Rose Highway (Nevada...

  9. DIAGNOSIS OF EGG MARKETING CONDITION IN SINOP - MT

    Directory of Open Access Journals (Sweden)

    M. Ribeiro

    2015-10-01

    Full Text Available The eggs, when manipulated in inadequate sanitary conditions, are considered as ways for development and multiplication of spoilage and pathogenic microorganisms. Thus, the objective was to evaluate the microbiological quality of eggs marketed out at Sinop – MT, through the identification of Salmonella spp., count of aerobic mesophile bacteria and enterobacteria. We collected 12 eggs from each establishment, three supermarkets and three fairs. Were not identified Salmonella spp. in egg shells and internal content. Escherichia coli was isolated from the internal contents of eggs come from an street fair. In aerobic mesophilic counts were obtained from eggs supermarkets counts CFU/g/egg shell of 5,8 x 105, 1,21 x 105 e 4,7 x 103. In relation to the fairs, the counts were 7,2 x 104, 5,66 x 104 e 8,7 x 103. The absence of Salmonella spp. the evaluated eggs classifies them as fit for consumption for compliance with current legislation. However, the presence of E. coli and the values of aerobic mesophilic counts and Enterobacteriaceae highlight the need to establish measures to reduce bacterial contamination of shell eggs sold out at Sinop, MT.

  10. Vulnerability of settlements around Mt. Cameroon volcano, Cameroon

    Science.gov (United States)

    Zogning, Appolinaire; Spinetti, Claudia; Ngouanet, Chretien; Tchoudam, David; Kouokam, Emmanuel; Thierry, Pierre; Bignami, Christian; Fabrizia Buongiorno, Maria; Ilaria Pannaccione Apa, Maria

    2010-05-01

    Located at the bottom of the Gulf of Guinea, Cameroon is exposed to a large variety of natural hazards, including volcanism. Most of the hazard are concentrated around the active volcano Mt. Cameroon which combines effusive and explosive types of activity. The threatened stakes are numerous and different exposed: people, settlements, industrial plantations, petrol refinery and many other factories and infrastructures. Until 2005, no risk management plans has been available. In 2006, the French Embassy in Cameroon, within the framework of a financial convention between Cameroon and France, put in place the GRINP (Management of Natural Risks and Civil Protection) project whose objective was to reinforce the capacity of Cameroon's civil protection department and thus, contribute to the improvement of the security of the population faced with catastrophes. The objective was to realize a Risk Prevention Plan at a local council scale, and taking into consideration the specific natural risks of each zone. The general objective of the RPP was to clearly draw land use maps for risks zones, showing the overlay of stakes with risk of different intensities. In 2008 European Commission funded the Mia-Vita project (Mitigating and Assessing Volcanic Impacts on Terrain and human Activities). The aim of the project is to improve the crisis management capabilities based on monitoring and early warning systems and secure communications; reduction of people's vulnerability and development of recovering capabilities after an event occurs for both local communities and ecological systems. Keyword: natural hazards, Mt. Cameroon, vulnerability, risk prevention plan

  11. Natural radioactivity in volcanic ash from Mt. Pinatubo eruption

    International Nuclear Information System (INIS)

    Duran, E.B.; De Vera, C.M.; Garcia, T.Y.; Dela Cruz, F.M.; Esguerra, L.V.; Castaneda, S.S.

    1992-01-01

    Last June 15, 1991, a major pyroclastic eruption occurred from Mt. Pinatubo volcano located in Zambales, Central Luzon. The radiological impact of this eruption was assessed based on the concentrations of the principal naturally occurring radionuclides observed in volcanic ash. The volcanic ash samples were collected from locations which are within 50-km radius of Mt. Pinatubo at various times after the eruption. The mean activity concentrations in Bq/kg wet weight of the natural radionuclides in volcanic ash were as follows: 12.6 for 238 U, 14.0 for 232 Th and 330 for 40 K. These values are significantly higher than the mean activity concentrations of these radionuclides observed in topsoil in the same provinces before the eruption. This suggests that with the deposition of large quantities of volcanic ash and lahar in Central Luzon and concomitant topographic changes, the distribution and quantities of radionuclides which gave rise to terrestrial radiation may have also changed. Outdoor radon concentrations measured three days and later after the eruption were within normal background values. (auth.). 4 refs.; 5 tabs.; 1 fig

  12. Reservoir characterization of the Mt. Simon Sandstone, Illinois Basin, USA

    Science.gov (United States)

    Frailey, S.M.; Damico, J.; Leetaru, H.E.

    2011-01-01

    The integration of open hole well log analyses, core analyses and pressure transient analyses was used for reservoir characterization of the Mt. Simon sandstone. Characterization of the injection interval provides the basis for a geologic model to support the baseline MVA model, specify pressure design requirements of surface equipment, develop completion strategies, estimate injection rates, and project the CO2 plume distribution.The Cambrian-age Mt. Simon Sandstone overlies the Precambrian granite basement of the Illinois Basin. The Mt. Simon is relatively thick formation exceeding 800 meters in some areas of the Illinois Basin. In the deeper part of the basin where sequestration is likely to occur at depths exceeding 1000 m, horizontal core permeability ranges from less than 1 ?? 10-12 cm 2 to greater than 1 ?? 10-8 cm2. Well log and core porosity can be up to 30% in the basal Mt. Simon reservoir. For modeling purposes, reservoir characterization includes absolute horizontal and vertical permeability, effective porosity, net and gross thickness, and depth. For horizontal permeability, log porosity was correlated with core. The core porosity-permeability correlation was improved by using grain size as an indication of pore throat size. After numerous attempts to identify an appropriate log signature, the calculated cementation exponent from Archie's porosity and resistivity relationships was used to identify which porosity-permeability correlation to apply and a permeability log was made. Due to the relatively large thickness of the Mt. Simon, vertical permeability is an important attribute to understand the distribution of CO2 when the injection interval is in the lower part of the unit. Only core analyses and specifically designed pressure transient tests can yield vertical permeability. Many reservoir flow models show that 500-800 m from the injection well most of the CO2 migrates upward depending on the magnitude of the vertical permeability and CO2 injection

  13. Myopathic mtDNA Depletion Syndrome Due to Mutation in TK2 Gene.

    Science.gov (United States)

    Martín-Hernández, Elena; García-Silva, María Teresa; Quijada-Fraile, Pilar; Rodríguez-García, María Elena; Rivera, Henry; Hernández-Laín, Aurelio; Coca-Robinot, David; Fernández-Toral, Joaquín; Arenas, Joaquín; Martín, Miguel A; Martínez-Azorín, Francisco

    2017-01-01

    Whole-exome sequencing was used to identify the disease gene(s) in a Spanish girl with failure to thrive, muscle weakness, mild facial weakness, elevated creatine kinase, deficiency of mitochondrial complex III and depletion of mtDNA. With whole-exome sequencing data, it was possible to get the whole mtDNA sequencing and discard any pathogenic variant in this genome. The analysis of whole exome uncovered a homozygous pathogenic mutation in thymidine kinase 2 gene ( TK2; NM_004614.4:c.323 C>T, p.T108M). TK2 mutations have been identified mainly in patients with the myopathic form of mtDNA depletion syndromes. This patient presents an atypical TK2-related myopathic form of mtDNA depletion syndromes, because despite having a very low content of mtDNA (TK2 gene in mtDNA depletion syndromes and expanded the phenotypic spectrum.

  14. Genetic dysfunction of MT-ATP6 causes axonal Charcot-Marie-Tooth disease.

    LENUS (Irish Health Repository)

    Pitceathly, Robert D S

    2012-09-11

    Charcot-Marie-Tooth (CMT) disease is the most common inherited neuromuscular disorder, affecting 1 in 2,500 individuals. Mitochondrial DNA (mtDNA) mutations are not generally considered within the differential diagnosis of patients with uncomplicated inherited neuropathy, despite the essential requirement of ATP for axonal function. We identified the mtDNA mutation m.9185T>C in MT-ATP6, encoding the ATP6 subunit of the mitochondrial ATP synthase (OXPHOS complex V), at homoplasmic levels in a family with mitochondrial disease in whom a severe motor axonal neuropathy was a striking feature. This led us to hypothesize that mutations in the 2 mtDNA complex V subunit encoding genes, MT-ATP6 and MT-ATP8, might be an unrecognized cause of isolated axonal CMT and distal hereditary motor neuropathy (dHMN).

  15. Exercise Intolerance and Myoglobinuria Associated with a Novel Maternally Inherited MT-ND1 Mutation

    DEFF Research Database (Denmark)

    Rafiq, Jabin; Duno, Morten; Østergaard, Elsebet

    2016-01-01

    The most common clinical phenotype caused by a mtDNA mutation in complex I of the mitochondrial respiratory chain is Leber hereditary optic neuropathy. We report a family with a novel maternally inherited homoplasmic mtDNA m.4087A>G mutation in the ND1 gene (MT-ND1) associated with isolated...... myopathy, recurrent episodes of myoglobinuria, and rhabdomyolysis. DNA from blood in seven family members and muscle from four family members were PCR amplified and sequenced directly and assessed for the m.4087A>G variation in MT-ND1. Mitochondrial enzyme activity in all muscle biopsies was measured. PCR...... myoglobinuria is a rare phenotype of mitochondrial myopathies. We report this phenotype in a family affected by a novel homoplasmic mutation in MT-ND1. It is the first time such a phenotype has been associated with complex I gene mutations and a homoplasmic mutation of mtDNA....

  16. Regulation of anthocyanin and proanthocyanidin biosynthesis by Medicago truncatula bHLH transcription factor MtTT8.

    Science.gov (United States)

    Li, Penghui; Chen, Beibei; Zhang, Gaoyang; Chen, Longxiang; Dong, Qiang; Wen, Jiangqi; Mysore, Kirankumar S; Zhao, Jian

    2016-05-01

    The MYB- basic helix-loop-helix (bHLH)-WD40 complexes regulating anthocyanin and proanthocyanidin (PA) biosynthesis in plants are not fully understood. Here Medicago truncatula bHLH MtTT8 was characterized as a central component of these ternary complexes that control anthocyanin and PA biosynthesis. Mttt8 mutant seeds have a transparent testa phenotype with reduced PAs and anthocyanins. MtTT8 restores PA and anthocyanin productions in Arabidopsis tt8 mutant. Ectopic expression of MtTT8 restores anthocyanins and PAs in mttt8 plant and hairy roots and further enhances both productions in wild-type hairy roots. Transcriptomic analyses and metabolite profiling of mttt8 mutant seeds and M. truncatula hairy roots (mttt8 mutant, mttt8 mutant complemented with MtTT8, or MtTT8 overexpression lines) indicate that MtTT8 regulates a subset of genes involved in PA and anthocyanin biosynthesis. MtTT8 is genetically regulated by MtLAP1, MtPAR and MtWD40-1. Combinations of MtPAR, MtLAP1, MtTT8 and MtWD40-1 activate MtTT8 promoter in yeast assay. MtTT8 interacts with these transcription factors to form regulatory complexes. MtTT8, MtWD40-1 and an MYB factor, MtPAR or MtLAP1, interacted and activated promoters of anthocyanidin reductase and anthocyanidin synthase to regulate PA and anthocyanin biosynthesis, respectively. Our results provide new insights into the complex regulation of PA and anthocyanin biosynthesis in M. truncatula. © 2016 The Authors. New Phytologist © 2016 New Phytologist Trust.

  17. Energy density of lake whitefish Coregonus clupeaformis in Lakes Huron and Michigan

    Science.gov (United States)

    Pothoven, S.A.; Nalepa, T.F.; Madenjian, C.P.; Rediske, R.R.; Schneeberger, P.J.; He, J.X.

    2006-01-01

    We collected lake whitefish Coregonus clupeaformis off Alpena and Tawas City, Michigan, USA in Lake Huron and off Muskegon, Michigan USA in Lake Michigan during 2002–2004. We determined energy density and percent dry weight for lake whitefish from both lakes and lipid content for Lake Michigan fish. Energy density increased with increasing fish weight up to 800 g, and then remained relatively constant with further increases in fish weight. Energy density, adjusted for weight, was lower in Lake Huron than in Lake Michigan for both small (≤800 g) and large fish (>800 g). Energy density did not differ seasonally for small or large lake whitefish or between adult male and female fish. Energy density was strongly correlated with percent dry weight and percent lipid content. Based on data from commercially caught lake whitefish, body condition was lower in Lake Huron than Lake Michigan during 1981–2003, indicating that the dissimilarity in body condition between the lakes could be long standing. Energy density and lipid content in 2002–2004 in Lake Michigan were lower than data for comparable sized fish collected in 1969–1971. Differences in energy density between lakes were attributed to variation in diet and prey energy content as well as factors that affect feeding rates such as lake whitefish density and prey abundance.

  18. Evaluating Michigan's community hospital access: spatial methods for decision support

    Directory of Open Access Journals (Sweden)

    Varnakovida Pariwate

    2006-09-01

    Full Text Available Abstract Background Community hospital placement is dictated by a diverse set of geographical factors and historical contingency. In the summer of 2004, a multi-organizational committee headed by the State of Michigan's Department of Community Health approached the authors of this paper with questions about how spatial analyses might be employed to develop a revised community hospital approval procedure. Three objectives were set. First, the committee needed visualizations of both the spatial pattern of Michigan's population and its 139 community hospitals. Second, the committee required a clear, defensible assessment methodology to quantify access to existing hospitals statewide, taking into account factors such as distance to nearest hospital and road network density to estimate travel time. Third, the committee wanted to contrast the spatial distribution of existing community hospitals with a theoretical configuration that best met statewide demand. This paper presents our efforts to first describe the distribution of Michigan's current community hospital pattern and its people, and second, develop two models, access-based and demand-based, to identify areas with inadequate access to existing hospitals. Results Using the product from the access-based model and contiguity and population criteria, two areas were identified as being "under-served." The lower area, located north/northeast of Detroit, contained the greater total land area and population of the two areas. The upper area was centered north of Grand Rapids. A demand-based model was applied to evaluate the existing facility arrangement by allocating daily bed demand in each ZIP code to the closest facility. We found 1,887 beds per day were demanded by ZIP centroids more than 16.1 kilometers from the nearest existing hospital. This represented 12.7% of the average statewide daily bed demand. If a 32.3 kilometer radius was employed, unmet demand dropped to 160 beds per day (1

  19. Characterization of pancreatic lesions from MT-tgf alpha, Ela-myc and MT-tgf alpha/Ela-myc single and double transgenic mice.

    Science.gov (United States)

    Liao, Dezhong Joshua; Wang, Yong; Wu, Jiusheng; Adsay, Nazmi Volkan; Grignon, David; Khanani, Fayyaz; Sarkar, Fazlul H

    2006-07-05

    In order to identify good animal models for investigating therapeutic and preventive strategies for pancreatic cancer, we analyzed pancreatic lesions from several transgenic models and made a series of novel findings. Female MT-tgf alpha mice of the MT100 line developed pancreatic proliferation, acinar-ductal metaplasia, multilocular cystic neoplasms, ductal adenocarcinomas and prominent fibrosis, while the lesions in males were less severe. MT-tgf alpha-ES transgenic lines of both sexes developed slowly progressing lesions that were similar to what was seen in MT100 males. In both MT100 and MT-tgf alpha-ES lines, TGF alpha transgene was expressed mainly in proliferating ductal cells. Ela-myc transgenic mice with a mixed C57BL/6, SJL and FVB genetic background developed pancreatic tumors at 2-7 months of age, and half of the tumors were ductal adenocarcinomas, similar to what was reported originally by Sandgren et al 1. However, in 20% of the mice, the tumors metastasized to the liver. MT100/Ela-myc and MT-tgf alpha-ES/Ela-myc double transgenic mice developed not only acinar carcinomas and mixed carcinomas as previously reported but also various ductal-originated lesions, including multilocular cystic neoplasms and ductal adenocarcinomas. The double transgenic tumors were more malignant and metastasized to the liver at a higher frequency (33%) compared with the Ela-myc tumors. Sequencing of the coding region of p16ink4, k-ras and Rb cDNA in small numbers of pancreatic tumors did not identify mutations. The short latency for tumor development, the variety of tumor morphology and the liver metastases seen in Ela-myc and MT-tgf alpha/Ela-myc mice make these animals good models for investigating new therapeutic and preventive strategies for pancreatic cancer.

  20. MT2-D inversion analysis in Kakkonda geothermal field; Kakkonda chinetsu chiiki ni okeru MT ho nijigen kaiseki

    Energy Technology Data Exchange (ETDEWEB)

    Yamane, K; Takasugi, S [Geothermal Energy Research and Development Co. Ltd., Tokyo (Japan); Miyazaki, S [Japan Metals and Chemicals Co. Ltd., Tokyo (Japan); Uchida, T [New Energy and Industrial Technology Development Organization, Tokyo, (Japan)

    1996-05-01

    Data, collected from an MT method-assisted survey conducted in the Kakkonda geothermal region in 1987, was re-examined, and a new structure was found. The review was carried out by use of a 2D analysis in the TM mode. According to the 1D analysis of 1987 and the geological data gathered then, it is estimated that the resistivity structure of this region runs in the northwest-southeast direction. A northeast-southwest traverse line was set for this analysis, orthogonal to the strike, and the impedance at each observation spot was caused to rotate to this direction across the whole range of frequency. Furthermore, in 1994-95, surveys were conducted using arrayed CSMT/MT methods. All these sum up to indicate that a high-resistivity region extends northwest in the southwestern part of the Kakkonda river but that there exists a low-resistivity region of several 10 Ohm m centering about the B traverse line. The high-resistivity region deep in the ground being the target of excavation in the Kakkonda region, to collect knowledge about this high-resistivity is important, and here the effectiveness of the 2d analysis has been verified. 5 refs., 11 figs.

  1. Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats.

    Science.gov (United States)

    Faria, Juliana A; Kinote, Andrezza; Ignacio-Souza, Letícia M; de Araújo, Thiago M; Razolli, Daniela S; Doneda, Diego L; Paschoal, Lívia B; Lellis-Santos, Camilo; Bertolini, Gisele L; Velloso, Lício A; Bordin, Silvana; Anhê, Gabriel F

    2013-07-15

    Melatonin can contribute to glucose homeostasis either by decreasing gluconeogenesis or by counteracting insulin resistance in distinct models of obesity. However, the precise mechanism through which melatonin controls glucose homeostasis is not completely understood. Male Wistar rats were administered an intracerebroventricular (icv) injection of melatonin and one of following: an icv injection of a phosphatidylinositol 3-kinase (PI3K) inhibitor, an icv injection of a melatonin receptor (MT) antagonist, or an intraperitoneal (ip) injection of a muscarinic receptor antagonist. Anesthetized rats were subjected to pyruvate tolerance test to estimate in vivo glucose clearance after pyruvate load and in situ liver perfusion to assess hepatic gluconeogenesis. The hypothalamus was removed to determine Akt phosphorylation. Melatonin injections in the central nervous system suppressed hepatic gluconeogenesis and increased hypothalamic Akt phosphorylation. These effects of melatonin were suppressed either by icv injections of PI3K inhibitors and MT antagonists and by ip injection of a muscarinic receptor antagonist. We conclude that melatonin activates hypothalamus-liver communication that may contribute to circadian adjustments of gluconeogenesis. These data further suggest a physiopathological relationship between the circadian disruptions in metabolism and reduced levels of melatonin found in type 2 diabetes patients.

  2. Metabolic rescue in pluripotent cells from patients with mtDNA disease.

    Science.gov (United States)

    Ma, Hong; Folmes, Clifford D L; Wu, Jun; Morey, Robert; Mora-Castilla, Sergio; Ocampo, Alejandro; Ma, Li; Poulton, Joanna; Wang, Xinjian; Ahmed, Riffat; Kang, Eunju; Lee, Yeonmi; Hayama, Tomonari; Li, Ying; Van Dyken, Crystal; Gutierrez, Nuria Marti; Tippner-Hedges, Rebecca; Koski, Amy; Mitalipov, Nargiz; Amato, Paula; Wolf, Don P; Huang, Taosheng; Terzic, Andre; Laurent, Louise C; Izpisua Belmonte, Juan Carlos; Mitalipov, Shoukhrat

    2015-08-13

    Mitochondria have a major role in energy production via oxidative phosphorylation, which is dependent on the expression of critical genes encoded by mitochondrial (mt)DNA. Mutations in mtDNA can cause fatal or severely debilitating disorders with limited treatment options. Clinical manifestations vary based on mutation type and heteroplasmy (that is, the relative levels of mutant and wild-type mtDNA within each cell). Here we generated genetically corrected pluripotent stem cells (PSCs) from patients with mtDNA disease. Multiple induced pluripotent stem (iPS) cell lines were derived from patients with common heteroplasmic mutations including 3243A>G, causing mitochondrial encephalomyopathy and stroke-like episodes (MELAS), and 8993T>G and 13513G>A, implicated in Leigh syndrome. Isogenic MELAS and Leigh syndrome iPS cell lines were generated containing exclusively wild-type or mutant mtDNA through spontaneous segregation of heteroplasmic mtDNA in proliferating fibroblasts. Furthermore, somatic cell nuclear transfer (SCNT) enabled replacement of mutant mtDNA from homoplasmic 8993T>G fibroblasts to generate corrected Leigh-NT1 PSCs. Although Leigh-NT1 PSCs contained donor oocyte wild-type mtDNA (human haplotype D4a) that differed from Leigh syndrome patient haplotype (F1a) at a total of 47 nucleotide sites, Leigh-NT1 cells displayed transcriptomic profiles similar to those in embryo-derived PSCs carrying wild-type mtDNA, indicative of normal nuclear-to-mitochondrial interactions. Moreover, genetically rescued patient PSCs displayed normal metabolic function compared to impaired oxygen consumption and ATP production observed in mutant cells. We conclude that both reprogramming approaches offer complementary strategies for derivation of PSCs containing exclusively wild-type mtDNA, through spontaneous segregation of heteroplasmic mtDNA in individual iPS cell lines or mitochondrial replacement by SCNT in homoplasmic mtDNA-based disease.

  3. Machine translation (MT): qualità, produttività, customer satisfaction

    OpenAIRE

    Fellet, Anna

    2010-01-01

    The aim of the present research is to examine the impact of recent technological developments in machine translation (MT) in the language industry. The objectives are: 1. To define the value of MT in terms of suitability and convenience in meeting expressed requirements in those cases where MT is demanded; 2. To examine the potential increase in productivity through a conscious use of the tool; 3. To analyse those activities aimed at satisfying the customer’s explicit and impli...

  4. Neoglacial fluctuations of Deming Glacier, Mt. Baker, Washington USA.

    Science.gov (United States)

    Osborn, G.; Menounos, B.; Scott, K.; Clague, J. J.; Tucker, D.; Riedel, J.; Davis, P.

    2007-12-01

    Deming Glacier flows from the upper west slopes of Mt. Baker, a stratovolcano in the Cascade Range of Washington, USA. The north and south lateral moraines of Deming Glacier are composed of at least four tills separated by layers of detrital wood and sheared stumps in growth position. The stratigraphy records fluctuations of the glacier during the Holocene. The outer ten rings of an in situ stump from the middle wood layer, which is about 40 m below the north lateral moraine crest and 1.2 km downvalley from the present glacier terminus, yielded an age of 1750 ± 50~~ 14C yr BP [1810-1550 cal yr BP]. The stump revealed at least 300 rings and thus records a period of landscape stability and relatively restricted glaciation for several hundred years prior to ca. 1750 14C yr BP . Samples from the lowest wood layer also have been submitted for radiocarbon dating. Outer rings of detrital wood samples collected from two wood mats exposed in the south lateral moraine, 2.3 km downvalley of the glacier terminus, returned radiocarbon ages of 1600 ± 30~~ 14C yr BP [1550- 1410 cal yr BP] and 430 ± 30~~ 14C yr BP [AD 1420-1620]. These data indicate that Deming Glacier advanced over a vegetated moraine sometime after 1810 cal yr BP to a position less extensive that it achieved at the peak of the Little Ice Age. The glacier then receded before it began its final and most extensive Holocene advance after AD 1420. The older advance is correlative with the 'First Millennium AD' advance, recently recognized throughout western North America. The younger advance coincides with an advance of Mt. Baker's Easton Glacier [AD 1430-1630], and advances of many alpine glaciers elsewhere in western North America. Our data suggest that glaciers on Mt. Baker fluctuated in a similar manner to alpine glaciers in the Coast Mountains of British Columbia and in other mountain ranges of northwest North America during Neoglaciation.

  5. Mitochondrial DNA copy number threshold in mtDNA depletion myopathy.

    Science.gov (United States)

    Durham, S E; Bonilla, E; Samuels, D C; DiMauro, S; Chinnery, P F

    2005-08-09

    The authors measured the absolute amount of mitochondrial DNA (mtDNA) within single muscle fibers from two patients with thymidine kinase 2 (TK2) deficiency and two healthy controls. TK2 deficient fibers containing more than 0.01 mtDNA/microm3 had residual cytochrome c oxidase (COX) activity. This defines the minimum amount of wild-type mtDNA molecules required to maintain COX activity in skeletal muscle and provides an explanation for the mosaic histochemical pattern seen in patients with mtDNA depletion syndrome.

  6. Estimates of Continental Ancestry Vary Widely among Individuals with the Same mtDNA Haplogroup

    Science.gov (United States)

    Emery, Leslie S.; Magnaye, Kevin M.; Bigham, Abigail W.; Akey, Joshua M.; Bamshad, Michael J.

    2015-01-01

    The association between a geographical region and an mtDNA haplogroup(s) has provided the basis for using mtDNA haplogroups to infer an individual’s place of origin and genetic ancestry. Although it is well known that ancestry inferences using mtDNA haplogroups and those using genome-wide markers are frequently discrepant, little empirical information exists on the magnitude and scope of such discrepancies between multiple mtDNA haplogroups and worldwide populations. We compared genetic-ancestry inferences made by mtDNA-haplogroup membership to those made by autosomal SNPs in ∼940 samples of the Human Genome Diversity Panel and recently admixed populations from the 1000 Genomes Project. Continental-ancestry proportions often varied widely among individuals sharing the same mtDNA haplogroup. For only half of mtDNA haplogroups did the highest average continental-ancestry proportion match the highest continental-ancestry proportion of a majority of individuals with that haplogroup. Prediction of an individual’s mtDNA haplogroup from his or her continental-ancestry proportions was often incorrect. Collectively, these results indicate that for most individuals in the worldwide populations sampled, mtDNA-haplogroup membership provides limited information about either continental ancestry or continental region of origin. PMID:25620206

  7. 77 FR 60137 - Lee Metcalf National Wildlife Refuge, Ravalli County, MT; Final Comprehensive Conservation Plan...

    Science.gov (United States)

    2012-10-02

    ... during regular business hours at 4567 Wildfowl Lane, Stevensville, MT. FOR FURTHER INFORMATION CONTACT... habitats and has created and modified wetlands. Riverfront forest includes early succession tree species...

  8. Decreased Circulating mtDNA Levels in Professional Male Volleyball Players.

    Science.gov (United States)

    Nasi, Milena; Cristani, Alessandro; Pinti, Marcello; Lamberti, Igor; Gibellini, Lara; De Biasi, Sara; Guazzaloca, Alessandro; Trenti, Tommaso; Cossarizza, Andrea

    2016-01-01

    Exercise exerts various effects on the immune system, and evidence is emerging on its anti-inflammatory effects; the mechanisms on the basis of these modifications are poorly understood. Mitochondrial DNA (mtDNA) released from damaged cells acts as a molecule containing the so-called damage-associated molecular patterns and can trigger sterile inflammation. Indeed, high plasma levels of mtDNA are associated to several inflammatory conditions and physiological aging and longevity. The authors evaluated plasma mtDNA in professional male volleyball players during seasonal training and the possible correlation between mtDNA levels and clinical parameters, body composition, and physical performance. Plasma mtDNA was quantified by real-time PCR every 2 mo in 12 professional volleyball players (PVPs) during 2 consecutive seasons. As comparison, 20 healthy nonathlete male volunteers (NAs) were analyzed. The authors found lower levels of mtDNA in plasma of PVPs than in NAs. However, PVPs showed a decrease of circulating mtDNA only in the first season, while no appreciable variations were observed during the second season. No correlation was observed among mtDNA, hematochemical, and anthropometric parameters. Regular physical activity appeared associated with lower levels of circulating mtDNA, further confirming the protective, anti-inflammatory effect of exercise.

  9. Nuclear DNA but not mtDNA controls tumor phenotypes in mouse cells

    International Nuclear Information System (INIS)

    Akimoto, Miho; Niikura, Mamoru; Ichikawa, Masami; Yonekawa, Hiromichi; Nakada, Kazuto; Honma, Yoshio; Hayashi, Jun-Ichi

    2005-01-01

    Recent studies showed high frequencies of homoplasmic mtDNA mutations in various human tumor types, suggesting that the mutated mtDNA haplotypes somehow contribute to expression of tumor phenotypes. We directly addressed this issue by isolating mouse mtDNA-less (ρ 0 ) cells for complete mtDNA replacement between normal cells and their carcinogen-induced transformants, and examined the effect of the mtDNA replacement on expression of tumorigenicity, a phenotype forming tumors in nude mice. The results showed that genome chimera cells carrying nuclear DNA from tumor cells and mtDNA from normal cells expressed tumorigenicity, whereas those carrying nuclear DNA from normal cells and mtDNA from tumor cells did not. These observations provided direct evidence that nuclear DNA, but not mtDNA, is responsible for carcinogen-induced malignant transformation, although it remains possible that mtDNA mutations and resultant respiration defects may influence the degree of malignancy, such as invasive or metastatic properties

  10. Answers to questions posed by the Michigan Governor's Nuclear Waste Disposal Task Force

    Energy Technology Data Exchange (ETDEWEB)

    1976-09-30

    A general presentation of the National Waste Terminal Storage (NWTS) Program was given on July 26, 1976, to the Michigan Environmental Review Board and the Michigan Governor's Nuclear Waste Disposal Task Force. Following the presentation, Dr. William G. Taylor, Chairman of the Task Force, provided ERDA with a listing of questions which pertained to the NWTS program and ERDA/OWI's interest in northeast Michigan. This document contains copies of the information which was provided to Dr. Taylor in response to his inquiry.

  11. The validity of the Michigan Alcoholism Screening Test (MAST)

    DEFF Research Database (Denmark)

    Storgaard, H; Nielsen, S D; Gluud, C

    1994-01-01

    This review examines the validity of the Michigan Alcoholism Screening Test (MAST) as a screening instrument for alcohol problems. Studies that compare the MAST-questionnaire with other defined diagnostic criteria of alcohol problems were retrieved through MEDLINE and a cross-bibliographic check....... A total of 20 validity studies were included. The studies varied considerably regarding the prevalence of alcohol problems, the diagnostic criteria, and the examined patient categories. The MAST compared with other diagnostic criteria of alcohol problems gave validity measures with the following span...... and the specificities show substantial variations. The variables that seem to have the largest influence on the PVpos seem to be the prevalence of alcohol problems, the diagnostic method against which the MAST-questionnaire is validated, and the populations on which the MAST is applied. The MAST should in the future...

  12. Arsenic species and chemistry in groundwater of southeast Michigan

    International Nuclear Information System (INIS)

    Kim, M.-J.; Nriagu, Jerome; Haack, Sheridan

    2002-01-01

    Most of the arsenic detected was arsenite [As(III)]. - Groundwater samples, taken from 73 wells in 10 counties of southeast Michigan in 1997 had arsenic concentrations in the range of 0.5 to 278 μg/l, the average being 29 μg/l. About 12% of these wells had arsenic concentrations that exceeded the current USEPA's maximum contaminant level of 50 μg/l. Most (53-98%) of the arsenic detected was arsenite [As(III)] and other observations supported the arsenic species distribution (low redox potential and DO). In shallow groundwater ( 15 m), the concentration of arsenic is possibly controlled by reductive dissolution of arsenic-rich iron hydroxide/oxyhydroxide and dissolution of arsenic sulfide minerals

  13. University of Michigan Comprehensive Cancer Center opportunities for improvement project.

    Science.gov (United States)

    Breslin, Tara M; Waldinger, Marcy; Silver, Samuel M

    2014-02-01

    The University of Michigan Comprehensive Cancer Center (UMCCC) Opportunities for Improvement project involved a detailed patient-level medical record review, feedback to medical providers and clinical leadership, and discussion of potential predictors of discordant or delayed care. The medical record review revealed that reasons for discordant or delayed care were well documented by clinical providers, and medical comorbidity was the most common predisposing factor. Another common theme was the difficulty in obtaining treatment records for patients who received a portion of their care outside UMCCC. The project provided a valuable opportunity to examine established processes of care and data collection and consider how the newly implemented electronic health record might support future efforts aimed at improving efficiency and communication among providers.

  14. Spatial Distribution of Black Bear Incident Reports in Michigan.

    Science.gov (United States)

    McFadden-Hiller, Jamie E; Beyer, Dean E; Belant, Jerrold L

    2016-01-01

    Interactions between humans and carnivores have existed for centuries due to competition for food and space. American black bears are increasing in abundance and populations are expanding geographically in many portions of its range, including areas that are also increasing in human density, often resulting in associated increases in human-bear conflict (hereafter, bear incidents). We used public reports of bear incidents in Michigan, USA, from 2003-2011 to assess the relative contributions of ecological and anthropogenic variables in explaining the spatial distribution of bear incidents and estimated the potential risk of bear incidents. We used weighted Normalized Difference Vegetation Index mean as an index of primary productivity, region (i.e., Upper Peninsula or Lower Peninsula), primary and secondary road densities, and percentage land cover type within 6.5-km2 circular buffers around bear incidents and random points. We developed 22 a priori models and used generalized linear models and Akaike's Information Criterion (AIC) to rank models. The global model was the best compromise between model complexity and model fit (w = 0.99), with a ΔAIC 8.99 units from the second best performing model. We found that as deciduous forest cover increased, the probability of bear incident occurrence increased. Among the measured anthropogenic variables, cultivated crops and primary roads were the most important in our AIC-best model and were both positively related to the probability of bear incident occurrence. The spatial distribution of relative bear incident risk varied markedly throughout Michigan. Forest cover fragmented with agriculture and other anthropogenic activities presents an environment that likely facilitates bear incidents. Our map can help wildlife managers identify areas of bear incident occurrence, which in turn can be used to help develop strategies aimed at reducing incidents. Researchers and wildlife managers can use similar mapping techniques to

  15. Project U-Turn: increasing active transportation in Jackson, Michigan.

    Science.gov (United States)

    TenBrink, David S; McMunn, Randall; Panken, Sarah

    2009-12-01

    Jackson, Michigan, is a medium-sized city suffering from a bad economy and obesity-related health issues. Nearly 20% of the 36,000 residents live below the poverty line. It is a relatively young city (median age of 30 years) with a mixed ethnicity (20% black, 73% white, 4% Hispanic). The city offers many structured, active recreational opportunities, but has not integrated physical activity into daily life. Project U-Turn aimed to increase active transportation (e.g., biking, walking, and transit use) through an integrated approach to Active Living by Design's community action model and the Michigan Safe Routes to School model. Resources were focused on active living promotions and programs; partnership meetings were the source of changes in policy and physical projects. Each initiative was designed to introduce each of the 5Ps (preparation, promotion, programs, policy, and physical projects) to build support for the partnership's overall work. The partnership collected snapshot data of community walking and biking behavior, percentage of students walking to school, participation in events and programs, and new physical projects. Jackson saw a vast improvement in physical infrastructure and policy and a related increase in walking and biking in the community. The project engaged in purposeful partnership building to implement effective programs and promotions that built support for policy and physical projects. Limited resources were best used by encouraging partners to contribute and coordinate activities using existing staff, funding, and resources. Jackson has seen a shift toward awareness of the benefits of active living on community health, economic development, and environmental awareness.

  16. Spatial Distribution of Black Bear Incident Reports in Michigan.

    Directory of Open Access Journals (Sweden)

    Jamie E McFadden-Hiller

    Full Text Available Interactions between humans and carnivores have existed for centuries due to competition for food and space. American black bears are increasing in abundance and populations are expanding geographically in many portions of its range, including areas that are also increasing in human density, often resulting in associated increases in human-bear conflict (hereafter, bear incidents. We used public reports of bear incidents in Michigan, USA, from 2003-2011 to assess the relative contributions of ecological and anthropogenic variables in explaining the spatial distribution of bear incidents and estimated the potential risk of bear incidents. We used weighted Normalized Difference Vegetation Index mean as an index of primary productivity, region (i.e., Upper Peninsula or Lower Peninsula, primary and secondary road densities, and percentage land cover type within 6.5-km2 circular buffers around bear incidents and random points. We developed 22 a priori models and used generalized linear models and Akaike's Information Criterion (AIC to rank models. The global model was the best compromise between model complexity and model fit (w = 0.99, with a ΔAIC 8.99 units from the second best performing model. We found that as deciduous forest cover increased, the probability of bear incident occurrence increased. Among the measured anthropogenic variables, cultivated crops and primary roads were the most important in our AIC-best model and were both positively related to the probability of bear incident occurrence. The spatial distribution of relative bear incident risk varied markedly throughout Michigan. Forest cover fragmented with agriculture and other anthropogenic activities presents an environment that likely facilitates bear incidents. Our map can help wildlife managers identify areas of bear incident occurrence, which in turn can be used to help develop strategies aimed at reducing incidents. Researchers and wildlife managers can use similar mapping

  17. The SAPPHIRE and 50 MT projects at BWXT, Lynchburg, VA

    International Nuclear Information System (INIS)

    Thiele, R.; Horn, B.; Coates, C.W.; Stainback, J.R.

    2001-01-01

    Full text: When the SAPPHIRE project for the down-blending of HEU material of Khazak origin was initiated in 1996 at BWX Technologies (BWXT) formally Babcock and Wilcox in Lynchburg, VA and the Agency was requested to apply its specially designed safeguards measures to the process with a view to provide assurance to the international community that down-blending had actually taken place as stipulated in the USA-Khazak agreement a learning process was initiated from this effort culminating in the current 50 MT downblending process at the same facility with BWXT, the USA Authorities, and the Agency as partners in this technologically advanced enterprise aimed at the downgrading of a substantial quantity of weapons grade material. In the present paper an overview is provided of the road leading to an effective, and mutually agreeable safeguards approach for carrying out verifications in the sensitive environment of a facility devoted to HEU uranium processing. (author)

  18. Mt. St. Helens' aerosols: some tropospheric and stratospheric effects

    International Nuclear Information System (INIS)

    Michalsky, J.J.; Stokes, G.M.

    1983-01-01

    Aerosol optical depth measurements based on the attenuation of direct solar radiation before and after the six major explosive eruptions of Mt. St. Helens during 1980 are presented. These automated measurements are from a site 200 km mostly east and slightly north of the volcano. From the analysis it was concluded that in several cases the conversion of sulfur gases to sulfates proceeded much more rapidly (hours) than is usually found for tropospheric conditions. A possible explanation may be the greater availability of OH due to the presence of substantial water in the plume. The second major result of the analysis was that there was no evidence of a residual aerosol burden. Turbidity data taken between eruptions in 1980 were virtually identical in terms of magnitude and wavelength dependence to 1979 turbidity

  19. Atmospheric mercury sources in the Mt. Amiata area, Italy

    International Nuclear Information System (INIS)

    Ferrara, R.; Mazzolai, B.; Edner, H.; Svanberg, S.; Wallinder, E.

    1998-01-01

    Mt. Amiata, located in southern Tuscany (Italy), is part of the geologic anomaly of the Mediterranean basin, which contains about 65% of the world's cinnabar (HgS) deposits. Atmospheric mercury emissions from the main sources (geothermal power plants, abandoned mine structures and spoil banks of roasted cinnabar ore) were determined by flux chamber and by LIDAR remote sensing. Mercury emissions from five geothermal power plants were on the order of 24 g h -1 for each plant, a value that remains constant throughout the year. In the month of July, the mine spoils (covering an area of =200000 m 2 ) emit a few grams of mercury per hour, while the abandoned mine structures give off 100-110 g h -1 . These two mercury sources were strongly influenced by ambient temperature. The area affected by mercury sources displays an average air mercury concentration of 20 ng m -3 during the summer and 10 ng m -3 in winter

  20. QUALITY CONTROL OF HYDROCHLOROTHIAZIDE TABLETS MARKETED IN SINOP-MT

    Directory of Open Access Journals (Sweden)

    M. K. Órfão

    2017-10-01

    Full Text Available The thiazide diuretics are of the classes of drugs most frequently used for the treatment of hypertension. Hydrochlorothiazide is the representative of this class and is found in tablet form in doses of 25 and 50 mg. It is marketed in three different categories of drugs: reference, similar and generic. According to the regulator in Brazil, the National Health Surveillance Agency (ANVISA, before pharmaceuticals are released for use, the pharmaceutical industry must meet product quality specifications, but the consumption of counterfeit drugs, contraband or without registration with government laws It is growing in Brazil, which affect the entire drug production chain affecting the health of those who use these medicines. In view of the reported problems about the quality of marketed drugs and being the state of Mato Grosso considered a fake gateway drug, due to its proximity to Bolivia, this study aimed to assess the quality of tablets containing hydrochlorothiazide is already one of the most widely used drugs in the treatment of hypertension in Sinop-MT municipality according local search. Samples from five laboratories that produce hydrochlorothiazide tablets at a dose of 25 mg, and the most market in the municipality of Sinop / MT were analyzed as stablished in the Brazilian Pharmacopoeia. It was found that four of the five samples of drugs in Mato Grosso, performed all the requirements for approval in quality testing, with the exception of a product that has lower hardness values than recommended, which can lead to problems drug presentation as well as directly affect the absorption, bioavailability and action of the therapeutic drug. It was concluded that medicinal products containing hydrochlorothiazide showed adequate quality, ensuring their effectiveness.

  1. Ethnobotany of the Samburu of Mt. Nyiru, South Turkana, Kenya

    Directory of Open Access Journals (Sweden)

    Bussmann Rainer W

    2006-09-01

    Full Text Available Abstract Traditional plant use is of extremely high importance in many societies, and prevalent in African communities. This knowledge is however dwindling rapidly due to changes towards a more Western lifestyle. The influence of modern tourism cannot be neglected in this context. This paper examines the plant use of the Samburu of the Mt. Nyiru area in Northern Kenya. The Samburu pastoralists of Kenya are still amongst the most traditional communities of the country and have retained most of their knowledge about the use of a large part of the plants in their environment for a wide variety of purposes. The results indicate that the local population has a very high knowledge of the plants in their surroundings, and attributes a purpose to a large percentage of the plants found. 448 plant species were collected, identified and their Samburu names and traditional uses recorded. 199 species were reported as of "no use". The high proportion of 249 plant species however had some traditional use: The highest number (180 species was used as fodder, followed by 80 species that had medicinal use. Firewood (59 species, construction (42 species, tools (31 species, food (29 species and ceremonial use (19 species ranked far behind. Traditionally the Samburu attribute most illnesses to the effect of pollutants that block or inhibit digestion. This can include "polluted" food, contagion through sick people as well as witchcraft. In most cases the treatment of illness involves herbal purgatives to cleanse the patient. There are however frequent indications of plant use for common problems like wounds, parasites, body aches and burns. The change from a nomadic to a more sedentary lifestyle, often observed in other areas of the country, has affected the Samburu of remote Mt. Nyiru to a much lesser extent and did so far not lead to a major loss of traditional plant knowledge. However, overgrazing and over-exploitation of plant resources have already led to a

  2. 3D Marine MT Modeling for a Topographic Seafloor

    Science.gov (United States)

    Zhang, B., Sr.; Yin, C.; Ren, X.; Liu, Y.; Huang, X.; Liu, L.

    2017-12-01

    As an effective geophysical tool, marine magnetotelluric (MMT) exploration has been widely used in offshore oil and gas exploration. Accordingly, the MMT forward modelling has made big progress. However, most of the researches are focused on a flat seafloor. In this paper, we present a 3D finite-element (FE) algorithm for marine MT forward modelling based on unstructured grids that can accurately model the MMT responses for a topographic seafloor. The boundary value problem for the forward modelling is described by an Helmholtz equation together with the boundary conditions derived by assuming the electrical polarizations respectively along the x- and y-direction on the top surface of the modelling domain. Applying the Galerkin method to the boundary value problem and substituting the unstructured finite-element vector shape function into the equation, we derive the final large linear system for the two polarizations, from which the EM fields is obtained for the calculation of impedance apparent resistivities and phases. To verify the effectiveness of our algorithm, we compare our modelling results with those by Key's (2013) 2D marine MT open source code of Scripps Institution of Oceanography (Figure 1). From Figure 1, one sees that the two agree well, implying that our 3D modelling method based unstructured FE is an effective modelling tool for topographic seafloor. From the MMT modelling responses for other topographic seafloor models (not shown here), we further observe that 1) the apparent resistivities have a similar profile pattern to the topography at the seafloor; 2) at the edges of the topography, there exist sharp changes; 3) the seafloor topography may dominate the responses from the abnormal bodies under the seafloor. This paper is supported by Key Program of National Natural Science Foundation of China (41530320), China Natural Science Foundation for Young Scientists (41404093), and Key National Research Project of China (2016YFC0303100, 2017YFC0601900)

  3. Optimized mtDNA Control Region Primer Extension Capture Analysis for Forensically Relevant Samples and Highly Compromised mtDNA of Different Age and Origin

    Directory of Open Access Journals (Sweden)

    Mayra Eduardoff

    2017-09-01

    Full Text Available The analysis of mitochondrial DNA (mtDNA has proven useful in forensic genetics and ancient DNA (aDNA studies, where specimens are often highly compromised and DNA quality and quantity are low. In forensic genetics, the mtDNA control region (CR is commonly sequenced using established Sanger-type Sequencing (STS protocols involving fragment sizes down to approximately 150 base pairs (bp. Recent developments include Massively Parallel Sequencing (MPS of (multiplex PCR-generated libraries using the same amplicon sizes. Molecular genetic studies on archaeological remains that harbor more degraded aDNA have pioneered alternative approaches to target mtDNA, such as capture hybridization and primer extension capture (PEC methods followed by MPS. These assays target smaller mtDNA fragment sizes (down to 50 bp or less, and have proven to be substantially more successful in obtaining useful mtDNA sequences from these samples compared to electrophoretic methods. Here, we present the modification and optimization of a PEC method, earlier developed for sequencing the Neanderthal mitochondrial genome, with forensic applications in mind. Our approach was designed for a more sensitive enrichment of the mtDNA CR in a single tube assay and short laboratory turnaround times, thus complying with forensic practices. We characterized the method using sheared, high quantity mtDNA (six samples, and tested challenging forensic samples (n = 2 as well as compromised solid tissue samples (n = 15 up to 8 kyrs of age. The PEC MPS method produced reliable and plausible mtDNA haplotypes that were useful in the forensic context. It yielded plausible data in samples that did not provide results with STS and other MPS techniques. We addressed the issue of contamination by including four generations of negative controls, and discuss the results in the forensic context. We finally offer perspectives for future research to enable the validation and accreditation of the PEC MPS

  4. Improving mobility and transportation options for Michigan's rural seniors : research spotlight.

    Science.gov (United States)

    2012-12-01

    Mobility challenges faced by older adults in : rural Michigan include long travel distances to obtain basic services or medical : care, and the limited availability of public, : private or volunteer transportation providers. Because of these challeng...

  5. 75 FR 70595 - Limited Service Domestic Voyage Load Lines for River Barges on Lake Michigan

    Science.gov (United States)

    2010-11-18

    ... similar request for an eastern Lake Michigan route between Chicago, IL, and Muskegon, MI. The motivation... tow loaded with wheat departed from Milwaukee and traveled southbound for Chicago. Although the 48...

  6. Weatherization is a Hit in Michigan: Weatherization Assistance Close-Up Fact Sheet

    International Nuclear Information System (INIS)

    2001-01-01

    Michigan demonstrates its commitment to technology and efficiency through the Weatherization Program. Weatherization uses advanced technologies and techniques to reduce energy costs for low-income families by increasing the energy efficiency of their homes

  7. Societal costs of traffic crashes and crime in Michigan : 2011 update.

    Science.gov (United States)

    2011-06-01

    "Cost estimates, including both monetary and nonmonetary quality-of-life costs specific to Michigan, were : estimated for overall traffic crashes and index crimes by experts in the field of economics of traffic crashes : and crimes. These cost estima...

  8. 75 FR 29189 - Emerald Ash Borer; Addition of Quarantined Areas in Kentucky, Michigan, Minnesota, New York...

    Science.gov (United States)

    2010-05-25

    ..., Indiana, Minnesota, Michigan, Ohio, Pennsylvania, West Virginia, and Wisconsin have already been..., Henry, Jefferson, Jessamine, Kenton, Oldham, Owen, Pendleton, Scott, Shelby, Trimble, and Woodford.... Shelby County. The entire county. Trimble County. The entire county. Woodford County. The entire county...

  9. Preventing industrial pollution at its source: the final report of the Michigan source reduction initiative

    Energy Technology Data Exchange (ETDEWEB)

    None

    1999-09-01

    This report describes a collaborative effort between NRDC, Dow Chemical, and Michigan Environmental Groups. The effort resulted in the identification and implementation of 17 pollution prevention projects that reduced substantial quantities of wastes and emissions and saved Dow considerable money.

  10. Preventing industrial pollution at its source: the final report of the Michigan source reduction initiative; FINAL

    International Nuclear Information System (INIS)

    None

    1999-01-01

    This report describes a collaborative effort between NRDC, Dow Chemical, and Michigan Environmental Groups. The effort resulted in the identification and implementation of 17 pollution prevention projects that reduced substantial quantities of wastes and emissions and saved Dow considerable money

  11. 137Cs as a tracer of recent sedimentary processes in Lake Michigan

    Science.gov (United States)

    Cahill, R.A.; Steele, J.D.

    1986-01-01

    To determine recent sediment movement, we measured the levels of 137Cs (an artificial radionuclide produced during nuclear weapons testing) of 118 southern Lake Michigan samples and 27 in Green Bay. These samples, taken from 286 grab samples of the upper 3 cm of sediment, were collected in 1975 as part of a systematic study of Lake Michigan sediment. 137Cs levels correlated well with concentrations of organic carbon, lead, and other anthropogenic trace metals in the sediment. 137Cs had a higher correlation with silt-sized than with clay-sized sediment (0.55 and 0.46, respectively). Atmospherically derived 137Cs and trace metals are being redistributed by sedimentary processes in Lake Michigan after being incorporated in suspended sediment. We determined a distribution pattern of 137Cs that represents areas of southern Lake Michigan where sediment deposition is occurring. ?? 1986 Dr W. Junk Publishers.

  12. Total and methyl mercury, moisture, and porosity in Lake Michigan surficial sediment

    Data.gov (United States)

    U.S. Environmental Protection Agency — Total and methyl mercury, moisture content (%), and porosity were measured in Lake Michigan sediment by the U.S. Environmental Protection Agency/Office of Research...

  13. 78 FR 65380 - Notice of Inventory Completion: University of Michigan, Ann Arbor, MI

    Science.gov (United States)

    2013-10-31

    ... the University of Michigan, Ann Arbor, MI. The human remains were removed from Alpena, Isabella, Grand... removed from the Devil River Mound site (20AL1) in Alpena County, MI. A resident of Ossineke, MI...

  14. Michigan State Briefing Book for low-level radioactive waste management

    International Nuclear Information System (INIS)

    1980-11-01

    The Michigan State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Michigan. The profile is the result of a survey of NRC licensees in Michigan. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the discussion of relevant government agencies and activities, all of which may impact waste management practices in Michigan

  15. 76 FR 13508 - Ninth Coast Guard District Sector Realignment; Northern Lake Michigan and Lake Huron

    Science.gov (United States)

    2011-03-14

    ... Station Alpena from Group Sault Ste. Marie to Sectors Lake Michigan and Detroit, respectively. That... boundary adjustment is that Stations Charlevoix and Alpena will be reassigned to Sector Sault Ste. Marie...

  16. Social Vulnerability Index (SoVI) for Michigan based on 2000 Census Block Groups

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data depicts the social vulnerability of Michigan census block groups to environmental hazards. Data were culled primarily from the 2000 Decennial Census.

  17. 76 FR 36151 - Notice of Inventory Completion: Museum of Anthropology, University of Michigan, Ann Arbor, MI

    Science.gov (United States)

    2011-06-21

    ... made by Museum of Anthropology, University of Michigan, professional staff in consultation with... picked up on the plains near Fort Rice Dakota.'' No known individual was identified. No associated...

  18. Pavement subgrade MR design values for Michigan's seasonal changes : final report.

    Science.gov (United States)

    2009-07-22

    The resilient modulus (MR) of roadbed soil plays an integral role in the design of pavement systems. Currently, the : various regions of the Michigan Department of Transportation (MDOT) use different procedures to determine the : MR values. Most of t...

  19. Pavement subgrade MR design values for Michigan's seasonal changes : table E4.

    Science.gov (United States)

    2009-07-22

    The resilient modulus (MR) of roadbed soil plays an integral role in the design of pavement systems. Currently, the various regions of the Michigan Department of Transportation (MDOT) use different procedures to determine the MR values. Most of these...

  20. Pavement subgrade MR design values for Michigan's seasonal changes : table E5.

    Science.gov (United States)

    2010-06-22

    The resilient modulus (MR) of roadbed soil plays an integral role in the design of pavement systems. Currently, the various regions of the Michigan Department of Transportation (MDOT) use different procedures to determine the MR values. Most of these...

  1. Birth defects and genetic disorders among Arab Americans--Michigan, 1992-2003.

    Science.gov (United States)

    Yanni, Emad A; Copeland, Glenn; Olney, Richard S

    2010-06-01

    Birth defects and genetic disorders are leading causes of infant morbidity and mortality in many countries. Population-based data on birth defects among Arab-American children have not been documented previously. Michigan has the second largest Arab-American community in the United States after California. Using data from the Michigan Birth Defects Registry (MBDR), which includes information on parents' country of birth and ancestry, birth prevalences were estimated in offspring of Michigan women of Arab ancestry for 21 major categories of birth defects and 12 congenital endocrine, metabolic, and hereditary disorders. Compared with other non-Hispanic white children in Michigan, Arab-American children had similar or lower birth prevalences of the selected types of structural birth defects, with higher rates of certain hereditary blood disorders and three categories of metabolic disorders. These estimates are important for planning preconception and antenatal health care, genetic counseling, and clinical care for Arab Americans.

  2. MtCAS31 Aids Symbiotic Nitrogen Fixation by Protecting the Leghemoglobin MtLb120-1 Under Drought Stress in Medicago truncatula

    Directory of Open Access Journals (Sweden)

    Xin Li

    2018-05-01

    Full Text Available Symbiotic nitrogen fixation (SNF in legume root nodules injects millions of tons of nitrogen into agricultural lands and provides ammonia to non-legume crops under N-deficient conditions. During plant growth and development, environmental stresses, such as drought, salt, cold, and heat stress are unavoidable. This raises an interesting question as to how the legumes cope with the environmental stress along with SNF. Under drought stress, dehydrin proteins are accumulated, which function as protein protector and osmotic substances. In this study, we found that the dehydrin MtCAS31 (cold-acclimation-specific 31 functions in SNF in Medicago truncatula during drought stress. We found that MtCAS31 is expressed in nodules and interacts with leghemoglobin MtLb120-1. The interaction between the two proteins protects MtLb120-1 from denaturation under thermal stress in vivo. Compared to wild type, cas31 mutants display a lower nitrogenase activity, a lower ATP/ADP ratio, higher expression of nodule senescence genes and higher accumulation of amyloplasts under dehydration conditions. The results suggested that MtCAS31 protects MtLb120-1 from the damage of drought stress. We identified a new function for dehydrins in SNF under drought stress, which enriches the understanding of the molecular mechanism of dehydrins.

  3. Cisco (Coregonus artedii) mortalities in a southern Michigan lake, July 1968

    Science.gov (United States)

    Colby, Peter J.; Brooke, Larry T.

    1969-01-01

    Cisco die-offs are common in the summer in certain lakes of northern Indiana and southern Michigan, along the southern boundary of the national distribution of coregonine fishes. Although numerous cisco die-offs have been reported, few, if any, have been accompanied by environmental information at the time of the die-off. On 31 July and 1 August 1968, we investigated a cisco die-off on Halfmoon Lake, on the border of Washtenaw and Livingston Counties, Michigan.

  4. Hypervariable region polymorphism of mtDNA of recurrent oral ulceration in Chinese.

    Directory of Open Access Journals (Sweden)

    Mao Sun

    Full Text Available BACKGROUND: MtDNA haplogroups could have important implication for understanding of the relationship between the mutations of the mitochondrial genome and diseases. Distribution of a variety of diseases among these haplogroups showed that some of the mitochondrial haplogroups are predisposed to disease. To examine the susceptibility of mtDNA haplogroups to ROU, we sequenced the mtDNA HV1, HV2 and HV3 in Chinese ROU. METHODOLOGY/PRINCIPAL FINDINGS: MtDNA haplogroups were analyzed in the 249 cases of ROU patients and the 237 cases of healthy controls respectively by means of primer extension analysis and DNA sequencing. Haplogroups G1 and H were found significantly more abundant in ROU patients than in healthy persons, while haplogroups D5 and R showed a trend toward a higher frequency in control as compared to those in patients. The distribution of C-stretch sequences polymorphism in mtDNA HV1, HV2 and HV3 regions was found in diversity. CONCLUSIONS/SIGNIFICANCE: For the first time, the relationship of mtDNA haplogroups and ROU in Chinese was investigated. Our results indicated that mtDNA haplogroups G1 and H might constitute a risk factor for ROU, which possibly increasing the susceptibility of ROU. Meanwhile, haplogroups D5 and R were indicated as protective factors for ROU. The polymorphisms of C-stretch sequences might being unstable and influence the mtDNA replication fidelity.

  5. Infantile presentation of the mtDNA A3243G tRNA(Leu (UUR)) mutation.

    NARCIS (Netherlands)

    Okhuijsen-Kroes, E.J.; Trijbels, J.M.F.; Sengers, R.C.A.; Mariman, E.C.M.; Heuvel, L.P.W.J. van den; Wendel, U.A.H.; Koch, G.; Smeitink, J.A.M.

    2001-01-01

    Mitochondrial DNA (mtDNA) disorders are clinically very heterogeneous, ranging from single organ involvement to severe multisystem disease. One of the most frequently observed mtDNA mutations is the A-to-G transition at position 3243 of the tRNA(Leu (UUR)) gene. This mutation is often related to

  6. 77 FR 61248 - Establishment of Class E Airspace; Deer Lodge, MT

    Science.gov (United States)

    2012-10-09

    ...-0379; Airspace Docket No. 12-ANM-7 Establishment of Class E Airspace; Deer Lodge, MT AGENCY: Federal... at Deer Lodge-City- County Airport, Deer Lodge, MT. Controlled airspace is necessary to accommodate... procedures at Deer Lodge-City-County Airport. This improves the safety and management of Instrument Flight...

  7. Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction

    Science.gov (United States)

    Furda, Amy M.; Marrangoni, Adele M.; Lokshin, Anna; Van Houten, Bennett

    2013-01-01

    Mitochondrial DNA (mtDNA) is essential for proper mitochondrial function and encodes 22 tRNAs, 2 rRNAs and 13 polypeptides that make up subunits of complex I, III, IV, in the electron transport chain and complex V, the ATP synthase. Although mitochondrial dysfunction has been implicated in processes such as premature aging, neurodegeneration, and cancer, it has not been shown whether persistent mtDNA damage causes a loss of oxidative phosphorylation. We addressed this question by treating mouse embryonic fibroblasts with either hydrogen peroxide (H2O2) or the alkylating agent methyl methanesulfonate (MMS) and measuring several endpoints, including mtDNA damage and repair rates using QPCR, levels of mitochondrial- and nuclear-encoded proteins using antibody analysis, and a pharmacologic profile of mitochondria using the Seahorse Extracellular Flux Analyzer. We show that a 60 min treatment with H2O2 causes persistent mtDNA lesions, mtDNA loss, decreased levels of a nuclear-encoded mitochondrial subunit, a loss of ATP-linked oxidative phosphorylation and a loss of total reserve capacity. Conversely, a 60 min treatment with 2 mM MMS causes persistent mtDNA lesions but no mtDNA loss, no decrease in levels of a nuclear-encoded mitochondrial subunit, and no mitochondrial dysfunction. These results suggest that persistent mtDNA damage is not sufficient to cause mitochondrial dysfunction. PMID:22766155

  8. The Regulatory Mechanism of MLT/MT1 Signaling on the Growth of Antler Mesenchymal Cells

    Directory of Open Access Journals (Sweden)

    Feifei Yang

    2017-10-01

    Full Text Available Melatonin (MLT plays an important role in regulating the physiological cycle of seasonal breeding animals. Melatonin receptor I (MT1 is effectively expressed in the cambium layer of deer antler. However, the function and metabolic mechanism of MLT/MT1 signaling in the mesenchymal cells of sika deer remain to be further elucidated. In this work, we detected the effects of MLT/MT1 signaling on mesenchymal cells proliferation and the interaction between MLT/MT1 and IGF1/IGF1-R signaling. The results show that (1 deer antler mesenchymal cells actually express MT1; (2 exogenous melatonin significantly promotes mesenchymal cells proliferation, while MT1 knock-down significantly impairs the positive effects of melatonin; and (3 melatonin significantly enhanced IGF1/IGF1-R signaling, as both the expression of IGF1 and IGF-1R increased, while MT1 knock-down significantly decreased IGF1-R expression and IGF1 synthesis. In summary, these data verified that MLT/MT1 signaling plays a crucial role in antler mesenchymal proliferation, which may be mediated by IGF1/IGF1-R.

  9. [Whole Genome Sequencing of Human mtDNA Based on Ion Torrent PGM™ Platform].

    Science.gov (United States)

    Cao, Y; Zou, K N; Huang, J P; Ma, K; Ping, Y

    2017-08-01

    To analyze and detect the whole genome sequence of human mitochondrial DNA (mtDNA) by Ion Torrent PGM™ platform and to study the differences of mtDNA sequence in different tissues. Samples were collected from 6 unrelated individuals by forensic postmortem examination, including chest blood, hair, costicartilage, nail, skeletal muscle and oral epithelium. Amplification of whole genome sequence of mtDNA was performed by 4 pairs of primer. Libraries were constructed with Ion Shear™ Plus Reagents kit and Ion Plus Fragment Library kit. Whole genome sequencing of mtDNA was performed using Ion Torrent PGM™ platform. Sanger sequencing was used to determine the heteroplasmy positions and the mutation positions on HVⅠ region. The whole genome sequence of mtDNA from all samples were amplified successfully. Six unrelated individuals belonged to 6 different haplotypes. Different tissues in one individual had heteroplasmy difference. The heteroplasmy positions and the mutation positions on HVⅠ region were verified by Sanger sequencing. After a consistency check by the Kappa method, it was found that the results of mtDNA sequence had a high consistency in different tissues. The testing method used in present study for sequencing the whole genome sequence of human mtDNA can detect the heteroplasmy difference in different tissues, which have good consistency. The results provide guidance for the further applications of mtDNA in forensic science. Copyright© by the Editorial Department of Journal of Forensic Medicine

  10. Characterization of a Dairy Gyr herd with respect to its mitochondrial DNA (mt DNA origin

    Directory of Open Access Journals (Sweden)

    Anibal Eugênio Vercesi Filho

    2010-01-01

    Full Text Available The Zebu breeds were introduced in Brazil mainly in the last century by imports from the Indian subcontinent. When the Zebu cattle arrived, the national herd suffered a significative change by backcrossing the national cows of taurine origin with Zebu sires. These processes created a polymorphism in the mitochondrial DNA (mtDNA in the Zebu animals with are in a major part derived from backcrossing and sharing mtDNA of taurine origin. To verify the maternal origin of cows belonging to the Dairy Gyr herd of APTA, Mococa 60 females were analyzed and 33 presented mtDNA from Bos taurus origin and 27 presented mtDNA from Bos indicus origin. None of these animals presented patterns of both mtDNA origins, indicating absence of heteroplasmy for these mitochondrial genotypes.

  11. The expression characteristics of mt-ND2 gene in chicken.

    Science.gov (United States)

    Zhang, Wenwen; Hou, Lingling; Wang, Ting; Lu, Weiwei; Tao, Yafei; Chen, Wen; Du, Xiaohui; Huang, Yanqun

    2016-09-01

    Subunit 2 of NADH dehydrogenase (ND2) is encoded by the mt-ND2 gene and plays a critical role in controlling the production of the mitochondrial reactive oxygen species. Our study focused on exploring the mt-ND2 tissue expression patterns and the effects of energy restriction and dietary fat (linseed oil, corn oil, sesame oil or lard) level (2.5% and 5%) on its expression in chicken. The results showed that mt-ND2 gene was expressed in the 15 tissues of hybrid chickens with the highest level in heart and lowest level in pancreas tissue; 30% energy restriction did not significantly affect mt-ND2 mRNA level in chicken liver tissue. Both the mt-ND2 mRNA levels in chicken pectoralis (p chicken age (p chicken age (p chicken age.

  12. Establishing MICHCARB, a geological carbon sequestration research and education center for Michigan, implemented through the Michigan Geological Repository for Research and Education, part of the Department of Geosciences at Western Michigan University

    Energy Technology Data Exchange (ETDEWEB)

    Barnes, David A. [Western Michigan Univ., Kalamazoo MI (United States); Harrison, William B. [Western Michigan Univ., Kalamazoo MI (United States)

    2014-01-28

    The Michigan Geological Repository for Research and Education (MGRRE), part of the Department of Geosciences at Western Michigan University (WMU) at Kalamazoo, Michigan, established MichCarb—a geological carbon sequestration resource center by: • Archiving and maintaining a current reference collection of carbon sequestration published literature • Developing statewide and site-specific digital research databases for Michigan’s deep geological formations relevant to CO2 storage, containment and potential for enhanced oil recovery • Producing maps and tables of physical properties as components of these databases • Compiling all information into a digital atlas • Conducting geologic and fluid flow modeling to address specific predictive uses of CO2 storage and enhanced oil recovery, including compiling data for geological and fluid flow models, formulating models, integrating data, and running the models; applying models to specific predictive uses of CO2 storage and enhanced oil recovery • Conducting technical research on CO2 sequestration and enhanced oil recovery through basic and applied research of characterizing Michigan oil and gas and saline reservoirs for CO2 storage potential volume, injectivity and containment. Based on our research, we have concluded that the Michigan Basin has excellent saline aquifer (residual entrapment) and CO2/Enhanced oil recovery related (CO2/EOR; buoyant entrapment) geological carbon sequestration potential with substantial, associated incremental oil production potential. These storage reservoirs possess at least satisfactory injectivity and reliable, permanent containment resulting from associated, thick, low permeability confining layers. Saline aquifer storage resource estimates in the two major residual entrapment, reservoir target zones (Lower Paleozoic Sandstone and Middle Paleozoic carbonate and sandstone reservoirs) are in excess of 70-80 Gmt (at an overall 10% storage efficiency factor; an approximately

  13. No variation and low synonymous substitution rates in coral mtDNA despite high nuclear variation

    Directory of Open Access Journals (Sweden)

    Hellberg Michael E

    2006-03-01

    Full Text Available Abstract Background The mitochondrial DNA (mtDNA of most animals evolves more rapidly than nuclear DNA, and often shows higher levels of intraspecific polymorphism and population subdivision. The mtDNA of anthozoans (corals, sea fans, and their kin, by contrast, appears to evolve slowly. Slow mtDNA evolution has been reported for several anthozoans, however this slow pace has been difficult to put in phylogenetic context without parallel surveys of nuclear variation or calibrated rates of synonymous substitution that could permit quantitative rate comparisons across taxa. Here, I survey variation in the coding region of a mitochondrial gene from a coral species (Balanophyllia elegans known to possess high levels of nuclear gene variation, and estimate synonymous rates of mtDNA substitution by comparison to another coral (Tubastrea coccinea. Results The mtDNA surveyed (630 bp of cytochrome oxidase subunit I was invariant among individuals sampled from 18 populations spanning 3000 km of the range of B. elegans, despite high levels of variation and population subdivision for allozymes over these same populations. The synonymous substitution rate between B. elegans and T. coccinea (0.05%/site/106 years is similar to that in most plants, but 50–100 times lower than rates typical for most animals. In addition, while substitutions to mtDNA in most animals exhibit a strong bias toward transitions, mtDNA from these corals does not. Conclusion Slow rates of mitochondrial nucleotide substitution result in low levels of intraspecific mtDNA variation in corals, even when nuclear loci vary. Slow mtDNA evolution appears to be the basal condition among eukaryotes. mtDNA substitution rates switch from slow to fast abruptly and unidirectionally. This switch may stem from the loss of just one or a few mitochondrion-specific DNA repair or replication genes.

  14. mtDNA mutation C1494T, haplogroup A, and hearing loss in Chinese

    International Nuclear Information System (INIS)

    Wang Chengye; Kong Qingpeng; Yao Yonggang; Zhang Yaping

    2006-01-01

    Mutation C1494T in mitochondrial 12S rRNA gene was recently reported in two large Chinese families with aminoglycoside-induced and nonsyndromic hearing loss (AINHL) and was claimed to be pathogenic. This mutation, however, was first reported in a sample from central China in our previous study that was aimed to reconstruct East Asian mtDNA phylogeny. All these three mtDNAs formed a subclade defined by mutation C1494T in mtDNA haplogroup A. It thus seems that mutation C1494T is a haplogroup A-associated mutation and this matrilineal background may contribute a high risk for the penetrance of mutation C1494T in Chinese with AINHL. To test this hypothesis, we first genotyped mutation C1494T in 553 unrelated individuals from three regional Chinese populations and performed an extensive search for published complete or near-complete mtDNA data sets (>3000 mtDNAs), we then screened the C1494T mutation in 111 mtDNAs with haplogroup A status that were identified from 1823 subjects across China. The search for published mtDNA data sets revealed no other mtDNA besides the above-mentioned three carrying mutation C1494T. None of the 553 randomly selected individuals and the 111 haplogroup A mtDNAs was found to bear this mutation. Therefore, our results suggest that C1494T is a very rare event. The mtDNA haplogroup A background in general is unlikely to play an active role in the penetrance of mutation C1494T in AINHL

  15. Post-glacial recolonization of the Great Lakes region by the common gartersnake (Thamnophis sirtalis) inferred from mtDNA sequences.

    Science.gov (United States)

    Placyk, John S; Burghardt, Gordon M; Small, Randall L; King, Richard B; Casper, Gary S; Robinson, Jace W

    2007-05-01

    Pleistocene events played an important role in the differentiation of North American vertebrate populations. Michigan, in particular, and the Great Lakes region, in general, were greatly influenced by the last glaciation. While several hypotheses regarding the recolonization of this region have been advanced, none have been strongly supported. We generated 148 complete ND2 mitochondrial DNA (mtDNA) sequences from common gartersnake (Thamnophis sirtalis) populations throughout the Great Lakes region to evaluate phylogeographic patterns and population structure and to determine whether the distribution of haplotypic variants is related to the post-Pleistocene retreat of the Wisconsinan glacier. The common gartersnake was utilized, as it is believed to have been one of the primary vertebrate invaders of the Great Lakes region following the most recent period of glacial retreat and because it has been a model species for a variety of evolutionary, ecological, behavioral, and physiological studies. Several genetically distinct evolutionary lineages were supported by both genealogical and molecular population genetic analyses, although to different degrees. The geographic distribution of the majority of these lineages is interpreted as reflecting post-glacial recolonization dynamics during the late Pleistocene. These findings generally support previous hypotheses of range expansion in this region.

  16. Physical and chemical characteristics of Mt. St. Helens airborne debris

    International Nuclear Information System (INIS)

    Sedlacek, W.A.; Heiken, G.H.; Mroz, E.J.; Gladney, E.S.; Perrin, D.R.; Leifer, R.; Fisenne, I.; Hinchliffe, L.; Chuan, R.L.

    1980-01-01

    Tephra and aerosols from the May 18, 1980 eruption of Mt. St. Helens, Washington were sampled in the lower stratosphere with a WB-57F aircraft. The main body of the plume was intercepted over western Kansas on May 20, 48 hours after the eruption, at an altitude of 15.2 km. Concentrations on filter samples were 26 ng of SO 4 /g of air and 579 ng of ash/g of air. Angular glass pyroclasts ranged in size from 0.5 to 10 μm, with a mean grain size of 2 μm. Samples collected at altitudes of 16.7 and 12.5 km had only traces of SO 4 and ash. A second flight was flown, 72 hours after the eruption, on May 21. From north Texas to central Wyoming, at an altitude of 15.2 km, 4 /g of air were sampled. At an altitude of 18.3 km, from central Wyoming to NW New Mexico, the plume density and character were variable. Glassy pyroclasts similar to those sampled on the first flight range in size from 0.5 to 4 μm dia. Trace element analysis revealed some volatile element enrichment, but far less than previously observed in the plume from St. Augustine Volcano, 1976. Values of 210 Po/ 210 Pb were 0.7 to 1.32 comparable to the secular equilibrium value of 1.0 and far less than ratios previously reported by Lambert

  17. Urania in the Marketplace: The Selling of Mt. Palomar

    Science.gov (United States)

    Rumstay, Kenneth S.

    2016-01-01

    The 200-inch Hale telescope atop Mt. Palomar is one of the most iconic scientific facilities ever constructed. The world's largest optical telescope for over a quarter-century, it served as a symbol of hope for America during the Great Depression and in the post-war years. In 2016 we celebrate the eightieth anniversaries of the completion of the mirror blank, the start of construction of the dome and mounting, and the beginning of astronomical research at Palomar Observatory by Fritz Zwicky (with the 18-inch Schmidt camera).During its construction, and for many years after "first light" in 1949, the Hale telescope was prominently featured in numerous magazine advertisements. Most of these represented companies directly involved in its construction, notably Corning Glass Works, which was justly proud of its magnificent accomplishment. But companies only vaguely linked to the project, or not at all, also co-opted the mystique of "the World's Largest Eye" to promote their goods or services. Surprisingly, in light of the fact that it bore responsibility for fabricating the complex and innovative mounting, the Westinghouse Electric & Manufacturing Company appears to have run only a single advertisement (in The National Geographic Magazine) touting its contribution to the project.Examples of magazine advertisements spanning the period 1936 to 1959 are presented.This work was supported by a faculty scholarship grant from Valdosta State University.

  18. Magma reservoir at Mt. Vesuvius: Deeper than 10 km

    International Nuclear Information System (INIS)

    Natale, M.; Luongo, G.; Nunziata, C.; Panza, G.F.

    2005-07-01

    One- and two-dimensional Vp models were obtained by TomoVes experiment, all characterized by low Vp in the uppermost 500 m and a sharp discontinuity at about 2-3 km beneath the volcano. Large amplitude late arrivals were identified as P- to S-phases converted at the top, between 8 and 10 km deep, of a low velocity layer with a dramatic drop of Vs, from approximately 3.6 km/s to less than 1.0 km/s. Here we synthesize the interpretation of Rayleigh wave dispersion measurements, made by several authors, to delineate the extent of such anomalous layer of hot, partially molten, crust material. Our non-linear inversion of broad-band dispersion measurements, gives a thickness not greater than 0.35 km, if we assume Vs equal to 1.0 km/s. The volume occupied by this very low velocity layer, sill shaped, is compatible with the size of Mt. Vesuvius cone, but it develops above a much larger hot mass which could be the parental source as the erupted products are only few percent of magma chamber. (author)

  19. Eruption of Mt. Pinatubo and climate of Syowa Station

    Directory of Open Access Journals (Sweden)

    Susumu Kaneto

    1997-03-01

    Full Text Available During the last year of the Antarctic Climate Research (ACR period, two large volcanos erupted. In June 1991,the volcano Pinatubo in the Philippines Islands (15°N, 120°E erupted and injected a large volcanic cloud in to the lower and middle stratosphere. In August 1991,Mt. Hudson in southern Chile (46°S, 73°W erupted; its volcanic cloud reached to 18km. From NOAA/AVHRR data, within 1991,the volcanic aerosol of Pinatubo dispersed mainly in tropical latitudes and that of Hudson spread in the area south of 40°S. The eruption effects are investigated here by comparing meteorological observation results at Syowa Station (69°S, 39°E with global analyses. The optical observations which measure direct effects of eruption materials, show a large effect from late 1991. Abnormal deviations were detected in surface temperature and total ozone amount but the occurrence is retarded relative to global average occurrence. Effects on stratospheric temperature were not detected.

  20. Observations of cocooned Hydrobaenus (Diptera: Chironomidae) larvae in Lake Michigan

    Science.gov (United States)

    Tucker, Taaja R.; Hudson, Patrick L.; Riley, Stephen

    2016-01-01

    Larvae of the family Chironomidae have developed a variety of ways to tolerate environmental stress, including the formation of cocoons, which allows larvae to avoid unfavorable temperature conditions, drought, or competition with other chironomids. Summer cocoon formation by younger instars of the genus Hydrobaenus Fries allows persistence through increased temperatures and/or intermittent dry periods in arid regions or temporary habitats, but this behavior was not observed in the Great Lakes until the current study. Cocoon-aestivating Hydrobaenus sp. larvae were found in benthic grab samples collected in 2010–2013 near Sleeping Bear Dunes National Lakeshore in northern Lake Michigan with densities up to 7329/m2. The aestivating species was identified as Hydrobaenus johannseni (Sublette, 1967), and the associated chironomid community was typical for an oligotrophic nearshore system. Hydrobaenus cocoon formation in the Great Lakes was likely previously unnoticed due to the discrepancies between the genus' life history and typical benthos sampling procedures which has consequences for describing chironomid communities where Hydrobaenus is present.

  1. Complicating Counterspaces: Intersectionality and the Michigan Womyn's Music Festival.

    Science.gov (United States)

    McConnell, Elizabeth A; Todd, Nathan R; Odahl-Ruan, Charlynn; Shattell, Mona

    2016-06-01

    The counterspaces framework articulated by Case and Hunter (2012), follows from community psychology's long-standing interest in the potential for settings to promote well-being and liberatory responses to oppression. This framework proposes that certain settings (i.e., "counterspaces") facilitate a specific set of processes that promote the well-being of marginalized groups. We argue that an intersectional analysis is crucial to understand whether and how counterspaces achieve these goals. We draw from literature on safe spaces and present a case study of the Michigan Womyn's Music Festival (Michfest) to illustrate the value of an intersectional analysis and explore how these processes operate. Based on 20 in-person interviews, 23 responses to an online survey, and ethnographic field notes, we show how Michfest was characterized by a particular intersection of identities at the setting level, and intersectional diversity complicated experiences at the individual level. Moreover, intersectional identities provided opportunities for dialogue and change at the setting level, including the creation of counterspaces within counterspaces. Overall, we demonstrate the need to attend to intersectionality in counterspaces, and more broadly in how we conceptualize settings in community psychology. © Society for Community Research and Action 2016.

  2. Body burdens of heavy metals in Lake Michigan wetland turtles.

    Science.gov (United States)

    Smith, Dayna L; Cooper, Matthew J; Kosiara, Jessica M; Lamberti, Gary A

    2016-02-01

    Tissue heavy metal concentrations in painted (Chrysemys picta) and snapping (Chelydra serpentina) turtles from Lake Michigan coastal wetlands were analyzed to determine (1) whether turtles accumulated heavy metals, (2) if tissue metal concentrations were related to environmental metal concentrations, and (3) the potential for non-lethal sampling techniques to be used for monitoring heavy metal body burdens in freshwater turtles. Muscle, liver, shell, and claw samples were collected from painted and snapping turtles and analyzed for cadmium, chromium, copper, iron, lead, magnesium, manganese, and zinc. Turtle tissues had measurable quantities of all eight metals analyzed. Statistically significant correlations between tissue metal concentrations and sediment metal concentrations were found for a subset of metals. Metals were generally found in higher concentrations in the larger snapping turtles than in painted turtles. In addition, non-lethal samples of shell and claw were found to be possible alternatives to lethal liver and muscle samples for some metals. Human consumption of snapping turtles presents potential health risks if turtles are harvested from contaminated areas. Overall, our results suggest that turtles could be a valuable component of contaminant monitoring programs for wetland ecosystems.

  3. Effects of repealing the motorcycle helmet law in Michigan.

    Science.gov (United States)

    Hothem, Zachary; Simon, Robert; Barnes, Wesley; Mohammad, Azmath; Sevak, Shruti; Ziegler, Kathryn; Iacco, Anthony; Janczyk, Randy

    2017-09-01

    In 2012, Michigan repealed its universal helmet law. Our study assessed the clinical impact of this repeal. Our trauma database was queried retrospectively for 2 motorcycle riding seasons before and 3 seasons after repeal. On-scene death data was obtained from the Medical Examiner. Helmet use in hospitalized patients decreased after the helmet law repeal. Non-helmeted patients had a significant increased rate of head injury. Non-helmeted patients were more likely to die during hospitalization. While, helmet use and drugs/alcohol status significantly affected the risk for head injury, only drug/alcohol had a significant effect on overall mortality. Following helmet law repeal, helmet use has decreased. Helmet status and drug/alcohol use was found to significantly increase risk of head injury. Although overall mortality was only affected by drug/alcohol use, non-helmeted patients did have a higher inpatient mortality. These findings deserve furthermore study and may provide a basis for reinstating the universal helmet law. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Best Practices: The Neuroscience Program at Central Michigan University

    Science.gov (United States)

    Dunbar, Gary L.

    2015-01-01

    The original design of our program at Central Michigan University (CMU) and its evolving curriculum were directly influenced by Faculty for Undergraduate (FUN) workshops at Davidson College, Oberlin College, Trinity College, and Macalester College. The course content, laboratory exercises, and pedagogy used were informed by excellent articles in the Journal of Undergraduate Neuroscience Education (JUNE) and presentations at these FUN workshops and meetings over the years. Like the program at Baldwin-Wallace College, which was a previous winner of the Undergraduate Neuroscience Program of the Year Award, as selected by the Committee on Neuroscience Departments and Programs (CNDP) of the Society for Neuroscience (SfN, our program stresses the importance of inquiry-based, hands-on research experience for our undergraduates and utilizes a peer-mentoring system. A distinct advantage that is employed at CMU is the use of graduate student mentors, which allows us to expand our peer-mentorship to distinct research teams that are focused on a specific research project. Developing our program was not easy. The present manuscript reviews the long and arduous journey (including ways in which we navigated some difficult internal political issues) we made to build a strong program. Hopefully, this description may prove helpful for other evolving programs, in terms of avoiding certain pitfalls and overcoming obstacles, as well as selecting practices that have proven to be successful at our institution. PMID:26240523

  5. Bovine tuberculosis in free-ranging carnivores from Michigan.

    Science.gov (United States)

    Bruning-Fann, C S; Schmitt, S M; Fitzgerald, S D; Fierke, J S; Friedrich, P D; Kaneene, J B; Clarke, K A; Butler, K L; Payeur, J B; Whipple, D L; Cooley, T M; Miller, J M; Muzo, D P

    2001-01-01

    During a survey of carnivores and omnivores for bovine tuberculosis conducted in Michigan (USA) since 1996, Mycobacterium bovis was cultured from lymph nodes pooled from six coyotes (Canis latrans) (four adult female, two adult male), two adult male raccoons (Procyon lotor), one adult male red fox (Vulpes vulpes), and one 1.5-yr-old male black bear (Ursus americanus). One adult, male bobcat (Felis rufus) with histologic lesions suggestive of tuberculosis was negative on culture but positive for organisms belonging to the Mycobacterium tuberculosis complex when tested by polymerase chain reaction. All the tuberculous animals were taken from three adjoining counties where M. bovis is known to be endemic in the free-ranging white-tailed deer (Odocoileus virginianus) population. There were two coyotes, one raccoon, one red fox, and one bobcat infected in Alpena county. Montmorency County had two coyotes and one raccoon with M. bovis. Two coyotes and a bear were infected from Alcona County. These free-ranging carnivores/omnivores probably became infected with M. bovis through consumption of tuberculous deer. Other species included in the survey were opossum (Didelphis virginiana), gray fox (Urocyon cinereoargenteus), and badger (Taxidea taxus); these were negative for M. bovis.

  6. Notable decomposition products of senescing Lake Michigan Cladophora glomerata

    Science.gov (United States)

    Peller, Julie R.; Byappanahalli, Muruleedhara N.; Shively, Dawn A.; Sadowsky, Michael J.; Chun, Chan Lan; Whitman, Richard L.

    2013-01-01

    Massive accumulations of Cladophora, a ubiquitous, filamentous green alga, have been increasingly reported along Great Lakes shorelines, negatively affecting beach aesthetics, recreational activities, public health and beachfront property values. Previously, the decomposition byproducts of decaying algae have not been thoroughly examined. To better understand the negative consequences and potential merit of the stranded Cladophora, a three month mesocosm study of the dynamic chemical environment of the alga was conducted using fresh samples collected from southern Lake Michigan beaches. Typical fermentation products, such as organic acids, sulfide compounds, and alcohols were detected in the oxygen–deprived algae. Short chain carboxylic acids peaked on day seven, in correspondence with the lowest pH value. Most low molecular mass carbon compounds were eventually consumed, but 4-methylphenol, indole, and 3-methylindole were detected throughout the incubation period. Natural oils were detected in fresh and decomposing algae, indicating the stable nature of these compounds. The mesocosm experiment was validated by directly sampling the fluid within decomposing Cladophora mats in the field; many of the same compounds were found. This study suggests that the problematic Cladophora accumulations may be harvested for useful byproducts, thereby reducing the odiferous and potentially harmful mats stranded along the shorelines.

  7. Ethical Issues in Public Health Practice in Michigan

    Science.gov (United States)

    Gollust, Sarah E.; Goold, Susan D.; Jacobson, Peter D.

    2009-01-01

    Objectives. We sought to ascertain the types of ethical challenges public health practitioners face in practice and to identify approaches used to resolve such challenges. Methods. We conducted 45 semistructured interviews with public health practitioners across a range of occupations (e.g., health officers, medical directors, sanitarians, nurses) at 13 health departments in Michigan. Results. Through qualitative analysis, we identified 5 broad categories of ethical issues common across occupations and locations: (1) determining appropriate use of public health authority, (2) making decisions related to resource allocation, (3) negotiating political interference in public health practice, (4) ensuring standards of quality of care, and (5) questioning the role or scope of public health. Participants cited a variety of values guiding their decision-making that did not coalesce around core values often associated with public health, such as social justice or utilitarianism. Public health practitioners relied on consultations with colleagues to resolve challenges, infrequently using frameworks for decision-making. Conclusions. Public health practitioners showed a nuanced understanding of ethical issues and navigated ethical challenges with minimal formal assistance. Decision-making guides that are empirically informed and tailored for practitioners might have some value. PMID:19059850

  8. Travel to, and use of, twenty-one Michigan trails.

    Science.gov (United States)

    Price, Anna E; Reed, Julian A; Grost, Lisa; Harvey, Christina; Mantinan, Karah

    2013-03-01

    This study examined trail use among 857 trail users on 21 trails in Michigan from 2008 to 2011 using a valid and reliable intercept survey. Most of the 857 participants traveled to the trail from their home (92.6%), lived within 15 min of the trails (74.8%), and used active transport to travel to the trails 69.7%. The odds of active transport to the trails were greater among those who had not graduated high school (OR=3.49; 95% CI=1.02, 11.99) and high school graduates (OR=7.432; 95% CI=2.02, 27.30) compared to college graduates. Whites and adults also had greater odds of active transport than non-Whites (OR=3.160, 95% CI: 1.65, 6.05), and older adults (OR=1.75; 95% CI: 1.20, 2.54). The majority of respondents (89.7%) reported using trails for recreational purposes. A significantly greater proportion of females (73.3%) compared to males (64.7%) reported using the trail with others. The findings from this study might enable health and parks and recreation professionals to better promote physical activity on trails. Copyright © 2013 Elsevier Inc. All rights reserved.

  9. Joint 1D inversion of TEM and MT data and 3D inversion of MT data in the Hengill area, SW Iceland

    Energy Technology Data Exchange (ETDEWEB)

    Arnason, Knutur; Eysteinsson, Hjalmar; Hersir, Gylfi Pall [ISOR-Iceland GeoSurvey, Grensasvegi 9, 108 Reykjavik (Iceland)

    2010-03-15

    An extensive study of the resistivity structure of the Hengill area in SW Iceland was carried out by the combined use of TEM and MT soundings. Joint inversion of the collected data can correct for static shifts in the MT data, which can be severe due to large near-surface resistivity contrasts. Joint 1D inversion of 148 TEM/MT sounding pairs and a 3D inversion of a 60 sounding subset of the MT data were performed. The 3D inversion was based on full MT impedance tensors previously corrected for static shift. Both inversion approaches gave qualitatively similar results, and revealed a shallow resistivity layer reflecting conductive alteration minerals at temperatures of 100-240 C. They also delineated a deep conductor at 3-10 km depth. The reason for this deep-seated high conductivity is not fully understood. The distribution of the deep conductors correlates with a positive residual Bouguer gravity anomaly, and with transform tectonics inferred from seismicity. One model of the Hengill that is consistent with the well temperature data and the deep conductor that does not attenuate S-waves, is a group of hot, solidified, but still ductile magmatic intrusions that are closely associated with the heat source for the geothermal system. (author)

  10. The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication.

    Science.gov (United States)

    Zhang, Yi; Chen, Yong; Gucek, Marjan; Xu, Hong

    2016-05-17

    Early embryonic development features rapid nuclear DNA replication cycles, but lacks mtDNA replication. To meet the high-energy demands of embryogenesis, mature oocytes are furnished with vast amounts of mitochondria and mtDNA However, the cellular machinery driving massive mtDNA replication in ovaries remains unknown. Here, we describe a Drosophila AKAP protein, MDI that recruits a translation stimulator, La-related protein (Larp), to the mitochondrial outer membrane in ovaries. The MDI-Larp complex promotes the synthesis of a subset of nuclear-encoded mitochondrial proteins by cytosolic ribosomes on the mitochondrial surface. MDI-Larp's targets include mtDNA replication factors, mitochondrial ribosomal proteins, and electron-transport chain subunits. Lack of MDI abolishes mtDNA replication in ovaries, which leads to mtDNA deficiency in mature eggs. Targeting Larp to the mitochondrial outer membrane independently of MDI restores local protein synthesis and rescues the phenotypes of mdi mutant flies. Our work suggests that a selective translational boost by the MDI-Larp complex on the outer mitochondrial membrane might be essential for mtDNA replication and mitochondrial biogenesis during oogenesis. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

  11. Type of featural attention differentially modulates hMT+ responses to illusory motion aftereffects.

    Science.gov (United States)

    Castelo-Branco, Miguel; Kozak, Lajos R; Formisano, Elia; Teixeira, João; Xavier, João; Goebel, Rainer

    2009-11-01

    Activity in the human motion complex (hMT(+)/V5) is related to the perception of motion, be it either real surface motion or an illusion of motion such as apparent motion (AM) or motion aftereffect (MAE). It is a long-lasting debate whether illusory motion-related activations in hMT(+) represent the motion itself or attention to it. We have asked whether hMT(+) responses to MAEs are present when shifts in arousal are suppressed and attention is focused on concurrent motion versus nonmotion features. Significant enhancement of hMT(+) activity was observed during MAEs when attention was focused either on concurrent spatial angle or color features. This observation was confirmed by direct comparison of adapting (MAE inducing) versus nonadapting conditions. In contrast, this effect was diminished when subjects had to report on concomitant speed changes of superimposed AM. The same finding was observed for concomitant orthogonal real motion (RM), suggesting that selective attention to concurrent illusory or real motion was interfering with the saliency of MAE signals in hMT(+). We conclude that MAE-related changes in the global activity of hMT(+) are present provided selective attention is not focused on an interfering feature such as concurrent motion. Accordingly, there is a genuine MAE-related motion signal in hMT(+) that is neither explained by shifts in arousal nor by selective attention.

  12. Stimulatory Effects of Melatonin on Porcine In Vitro Maturation Are Mediated by MT2 Receptor

    Directory of Open Access Journals (Sweden)

    Sanghoon Lee

    2018-05-01

    Full Text Available Melatonin is a multifunctional molecule with numerous biological activities. The fact that melatonin modulates the functions of porcine granulosa cells via the MT2 receptor suggests the possibility of MT2 receptor-mediation for melatonin to promote cumulus expansion of porcine cumulus-oocyte complexes (COCs. Therefore, we investigated the presence of MT2 in porcine COCs, and the effects of melatonin with or without selective MT2 antagonists (luzindole and 4-P-PDOT on this process; COCs underwent in vitro maturation culturing with six different conditions (control, melatonin, luzindole, 4-P-PDOT, melatonin + luzindole or melatonin + 4-P-PDOT. Cumulus expansion, oocyte nuclear maturation, and subsequent embryo development after parthenogenetic activation (PA were evaluated. In experiment 1, MT2 was expressed in both oocytes and cumulus cells. In experiment 2, melatonin significantly increased the proportion of complete cumulus expansion (degree 4, which was inhibited by simultaneous addition of either luzindole or 4-P-PDOT. A similar pattern was observed in the expression of genes related to cumulus expansion, apoptosis, and MT2. In experiment 3, no significant difference was observed in immature, degenerate, and MII oocyte rates among the groups. In experiment 4, melatonin significantly increased blastocyst formation rates and total blastocyst cell numbers after PA, but these effects were abolished when either luzindole or 4-P-PDOT was added concomitantly. In conclusion, our results indicate that the MT2 receptor mediated the stimulatory effects of melatonin on porcine cumulus expansion and subsequent embryo development.

  13. Regulation of bone mass through pineal-derived melatonin-MT2 receptor pathway.

    Science.gov (United States)

    Sharan, Kunal; Lewis, Kirsty; Furukawa, Takahisa; Yadav, Vijay K

    2017-09-01

    Tryptophan, an essential amino acid through a series of enzymatic reactions gives rise to various metabolites, viz. serotonin and melatonin, that regulate distinct biological functions. We show here that tryptophan metabolism in the pineal gland favors bone mass accrual through production of melatonin, a pineal-derived neurohormone. Pineal gland-specific deletion of Tph1, the enzyme that catalyzes the first step in the melatonin biosynthesis lead to a decrease in melatonin levels and a low bone mass due to an isolated decrease in bone formation while bone resorption parameters remained unaffected. Skeletal analysis of the mice deficient in MT1 or MT2 melatonin receptors showed a low bone mass in MT2-/- mice while MT1-/- mice had a normal bone mass compared to the WT mice. This low bone mass in the MT2-/- mice was due to an isolated decrease in osteoblast numbers and bone formation. In vitro assays of the osteoblast cultures derived from the MT1-/- and MT2-/- mice showed a cell intrinsic defect in the proliferation, differentiation and mineralization abilities of MT2-/- osteoblasts compared to WT counterparts, and the mutant cells did not respond to melatonin addition. Finally, we demonstrate that daily oral administration of melatonin can increase bone accrual during growth and can cure ovariectomy-induced structural and functional degeneration of bone by specifically increasing bone formation. By identifying pineal-derived melatonin as a regulator of bone mass through MT2 receptors, this study expands the role played by tryptophan derivatives in the regulation of bone mass and underscores its therapeutic relevance in postmenopausal osteoporosis. © 2017 The Authors. Journal of Pineal Research Published by John Wiley & Sons Ltd.

  14. 75 FR 70691 - World Color Mt. Morris, IL LLC, Premedia Chicago Division, Currently Known as Quad/Graphics, Inc...

    Science.gov (United States)

    2010-11-18

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,142] World Color Mt. Morris... to Apply for Worker Adjustment Assistance on May 24, 2010, applicable to workers of World Color Mt... that on July 2, 2010, World Color Mt. Morris, IL LLC was purchased by Quad/Graphics, Inc. and is...

  15. Black Carbon at the Mt. Bachelor Observatory Field Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    Jaffe, Dan A. [Univ. of Washington, Bothell, WA (United States); Sedlacek, Arthur [Brookhaven National Lab. (BNL), Upton, NY (United States); Laing, James R. [Univ. of Washington, Bothell, WA (United States)

    2017-03-01

    This campaign was initiated to measure refractory black carbon (rBC, as defined in Schwarz et al. (2010)) at the Mt. Bachelor Observatory (MBO) using the U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Climate Research Facility single-particle soot photometer (SP2; unit 54). MBO is a high-elevation site located on the summit of Mt. Bachelor in central Oregon, USA (43.979°N, 121.687°W, 2,763 meters ASL). This site is operated by Professor Dan Jaffe’s group at the University of Washington Bothell and has been used continuously as an atmospheric observatory for the past 12 years (Jaffe et al., 2005; Gratz et al., 2014). The location of MBO allows frequent sampling of the free troposphere along with a wide array of plumes from regional and distant sources. MBO is currently supported with funding from the National Science Foundation (NSF) to the Principal Investigator (PI; D. Jaffe) via the project “Influence of Free Tropospheric Ozone and PM on Surface Air Quality in the Western U.S.” (#1447832) covering the period 03/15/2015 to 02/28/2018. The SP2 instrument from Droplet Measurement Technologies provides particle-resolved measurements of rBC mass loading, size and mass distributions, and mixing state. The SP2 was installed at MBO on 6/27/2016 and ran through 9/23/2016. Additional measurements at MBO during this campaign included carbon monoxide (CO), fine particulate matter (PM1), aerosol light scattering coefficients (σscat) at three wavelengths using a TSI nephelometer, aerosol absorption coefficients (σabs) with the Brechtel tricolor absorption photometer (TAP), aerosol number size distributions with a scanning mobility particle sizer spectrometer (SMPS), and black carbon (eBC) with an aethalometer. BC data from this campaign have been submitted to the ARM Data Archive. Black carbon (BC) is the predominant light-absorbing aerosol constituent in the atmosphere, and is estimated to exert a positive radiative forcing second only to CO

  16. Evapotranspiration dynamics along elevational and disturbance gradients at Mt. Kilimanjaro

    Science.gov (United States)

    Detsch, Florian; Otte, Insa; Appelhans, Tim; Nauß, Thomas

    2015-04-01

    Future climate characteristics of the Mt. Kilimanjaro region, Tanzania, will be governed by two superior processes: (i) global climate change and (ii) local land cover transformation. Whilst precipitation amounts remained stable throughout the last climate normals, recent studies revealed distinctly increasing air temperatures in the study region between 1973 and 2013, resulting in a gradual reduction of available moisture. In addition, climate predictions show rising temperatures over East Africa throughout the 21st century. Modifications of the local hydrological cycle resulting from land cover transformation will either favor or counteract the thus induced, increasing dryness. Considering that the local-scale climate is a key parameter for ecosystem processes and biodiversity, quantifying the driving components on the credit (precipitation, through-fall, fog) and debit side of the local-scale water balance is of outstanding (biogeo-)scientific importance. In this context, a multidisciplinary German research unit investigates the interrelationship between climate, land use and biodiversity along the southern slopes of Mt. Kilimanjaro. A total of 65 climate stations have been installed to record rainfall and estimate potential evaporation across different land cover types ranging from savanna (880 m a.s.l.) to the upper mountain Helichrysum sites (4,550 m a.s.l.). The associated data is used for both the area-wide interpolation of meteorological parameters and as input for satellite-based retrievals of rainfall and evapotranspiration (ET). We conducted an extensive field campaign employing a surface-layer scintillometer in order to gain insights into ET dynamics over different land cover types following elevational and disturbance gradients. Scintillometer measurements are available for study sites below (savanna, maize, grassland, coffee plantations) and above the forest belt (natural and disturbed ericaceous forest, Helichrysum), covering a period of 4-7 days

  17. Biothermal conditions on Mt. Zlatibor based on thermophysiological indices

    Directory of Open Access Journals (Sweden)

    Pecelj Milica

    2017-01-01

    Full Text Available This paper presents part of the research in the field of human bioclimatology and refers to biothermal conditions in different geographical environments in Serbia: an urban area and a mountain of medium height. The goal of the paper was to show bioclimatic differences during the summer between the city of Belgrade (116 m a.s.l. and the mountain resort of Zlatibor (1498 m a.s.l.. The basic principle of bioclimatic analysis is the human heat balance between man and environment. This methodological approach is a combination of physiological and meteorological parameters that result in thermophysiological bioclimatic indices: heat load (HL in man and the Universal Thermal Climate Index (UTCI. For this analysis, weather data for July, as the warmest month, was obtained, using daily meteorological data for the decade from 2000 to 2010. Results for July indicate a considerable difference between the two abovementioned environments. HL in Belgrade was dominated by degrees of comfort “hot” and “extremely hot, with the highest value of 4.540, while for Zlatibor the dominant degree of comfort was “warm”. The UTCI in Belgrade has dominated by strong heat stress and moderate heat stress, compared to Zlatibor where the UTCI is dominated by moderate heat stress. In addition, a significant part of the monitored decade on Mt. Zlatibor was without heat stress, with the exception of 2006 and 2007, indicating favorable biothermal characteristics. Therefore, compared to Belgrade, with its considerably lower overall heat stress Zlatibor has the characteristics of a site with favorable bioclimatic qualities.

  18. Geology of Mt. Taylor uranium mine, Grants, New Mexico

    International Nuclear Information System (INIS)

    Alief, M.H.; Kern, R.A.

    1989-01-01

    The Mt. Taylor uranium mine is located 25 mi due northeast of Grants, New Mexico. Gulf Mineral Resources attained interest in the property in 1971. Surface drilling outlined several orebodies extending for 7 mi and containing over 120 million lb of uranium oxide (U 3 O 8 ). Gulf sank two shafts and developed the orebody in Sec. 24, T13N, R8W. Due to depressed markets, the mine was shut down in 1982. Chevron reopened the mine in 1985 following the 1984 Gulf-Chevron merger. The uranium ore occurs in the Westwater Canyon Sandstone Member of the Jurassic Morrison Formation. The Westwater Canyon member was deposited as part of a braided-stream channel system. Mineralization was emplaced following the deposition and possibly prior to consolidation of the host. Uranium is intimately associated with carbonaceous matter that may have been deposited as humates prior to and/or contemporaneous with the uranium mineralization. Mineralization coats sand grains and fills intergranular voids. Since 1985, Chevron has produced more than 5 million lb of U 3 O 8 , most of it from Sec. 24 and Sec. 19 (T13N, R7W). Plans are to complete extraction in these sections and to continue southeasterly into Sec. 25 (T13N, R8W) and Sec. 30 (T13N, R7W). More than 40 million lb of U 3 O 8 may be mined from the present facilities. At the current mining rate of 1.5 million lb/year, supplies should take them well beyond the year 2000

  19. Ophthalmodynamometry for ICP prediction and pilot test on Mt. Everest.

    Science.gov (United States)

    Querfurth, Henry W; Lieberman, Philip; Arms, Steve; Mundell, Steve; Bennett, Michael; van Horne, Craig

    2010-11-01

    A recent development in non-invasive techniques to predict intracranial pressure (ICP) termed venous ophthalmodynamometry (vODM) has made measurements in absolute units possible. However, there has been little progress to show utility in the clinic or field. One important application would be to predict changes in actual ICP during adaptive responses to physiologic stress such as hypoxia. A causal relationship between raised intracranial pressure and acute mountain sickness (AMS) is suspected. Several MRI studies report that modest physiologic increases in cerebral volume, from swelling, normally accompany subacute ascent to simulated high altitudes. 1) Validate and calibrate an advanced, portable vODM instrument on intensive patients with raised intracranial pressure and 2) make pilot, non-invasive ICP estimations of normal subjects at increasing altitudes. The vODM was calibrated against actual ICP in 12 neurosurgical patients, most affected with acute hydrocephalus and monitored using ventriculostomy/pressure transducers. The operator was blinded to the transducer read-out. A clinical field test was then conducted on a variable data set of 42 volunteer trekkers and climbers scaling Mt. Everest, Nepal. Mean ICPs were estimated at several altitudes on the ascent both across and within subjects. Portable vODM measurements increased directly and linearly with ICP resulting in good predictability (r = 0.85). We also found that estimated ICP increases normally with altitude (10 ± 3 mm Hg; sea level to 20 ± 2 mm Hg; 6553 m) and that AMS symptoms did not correlate with raised ICP. vODM technology has potential to reliably estimate absolute ICP and is portable. Physiologic increases in ICP and mild-mod AMS are separate responses to high altitude, possibly reflecting swelling and vasoactive instability, respectively.

  20. Ophthalmodynamometry for ICP prediction and pilot test on Mt. Everest

    Directory of Open Access Journals (Sweden)

    Bennett Michael

    2010-11-01

    Full Text Available Abstract Background A recent development in non-invasive techniques to predict intracranial pressure (ICP termed venous ophthalmodynamometry (vODM has made measurements in absolute units possible. However, there has been little progress to show utility in the clinic or field. One important application would be to predict changes in actual ICP during adaptive responses to physiologic stress such as hypoxia. A causal relationship between raised intracranial pressure and acute mountain sickness (AMS is suspected. Several MRI studies report that modest physiologic increases in cerebral volume, from swelling, normally accompany subacute ascent to simulated high altitudes. Objectives 1 Validate and calibrate an advanced, portable vODM instrument on intensive patients with raised intracranial pressure and 2 make pilot, non-invasive ICP estimations of normal subjects at increasing altitudes. Methods The vODM was calibrated against actual ICP in 12 neurosurgical patients, most affected with acute hydrocephalus and monitored using ventriculostomy/pressure transducers. The operator was blinded to the transducer read-out. A clinical field test was then conducted on a variable data set of 42 volunteer trekkers and climbers scaling Mt. Everest, Nepal. Mean ICPs were estimated at several altitudes on the ascent both across and within subjects. Results Portable vODM measurements increased directly and linearly with ICP resulting in good predictability (r = 0.85. We also found that estimated ICP increases normally with altitude (10 ± 3 mm Hg; sea level to 20 ± 2 mm Hg; 6553 m and that AMS symptoms did not correlate with raised ICP. Conclusion vODM technology has potential to reliably estimate absolute ICP and is portable. Physiologic increases in ICP and mild-mod AMS are separate responses to high altitude, possibly reflecting swelling and vasoactive instability, respectively.

  1. Symptoms and treatment of mental illness among prisoners: a study of Michigan state prisons.

    Science.gov (United States)

    Fries, Brant E; Schmorrow, Angela; Lang, Sylvia W; Margolis, Philip M; Heany, Julia; Brown, Greg P; Barbaree, Howard E; Hirdes, John P

    2013-01-01

    This study reports on a representative sample of prisoners in Michigan correctional facilities to determine the prevalence of psychiatric illness and the delivery of mental health (MH) services. Mental health assessments were conducted with 618 incarcerated subjects using the interRAI Correctional Facilities (interRAI CF). Subjects were randomly sampled based on four strata: males in the general population, males in administrative segregation, males in special units, and females. The interRAI CF assessments were merged with secondary data provided by the Michigan Department of Corrections (MDOC) containing information on MH diagnoses or services that the subjects were receiving within the facilities, demographics, and sentencing. Study results show that 20.1% of men and 24.8% of women in Michigan prisons have a substantial level of MH symptoms and that 16.5% and 28.9%, respectively, are receiving MH services. However, when compared with Michigan Department of Corrections MH care records, 65.0% of prisoners who are experiencing symptoms of mental illness are not currently receiving any psychiatric services. The mis-match between symptoms and service delivery suggests the need for improved procedures for identifying and measuring psychiatric symptoms within Michigan correctional facilities to ensure that appropriate individuals receive needed care. It is recommended that a standardized assessment process be implemented and conducted at regular intervals for targeting and improving psychiatric care in the prison system. Copyright © 2013 Elsevier Ltd. All rights reserved.

  2. Nuclear power plant emergency preparedness: results from an evaluation of Michigan's potassium iodide distribution program.

    Science.gov (United States)

    Zwolinski, Laura R; Stanbury, Martha; Manente, Susan

    2012-10-01

    In 2009, the Michigan Department of Community Health (MDCH) made potassium iodide (KI), a nonprescription radio-protective drug, available by mailing vouchers redeemable at local pharmacies for KI tablets, at no cost to residents living within 10 miles of Michigan's 3 nuclear power plants (NPPs). MDCH conducted an evaluation of this program to determine Michigan's KI coverage and to assess general emergency preparedness among residents living near the NPPs. KI coverage was estimated based on redeemed voucher counts and the 2010 Census. Telephone surveys were administered to a random sample (N = 153) of residents living near Michigan's NPPs to evaluate general emergency preparedness, reasons for voucher use or nonuse, and KI knowledge. Only 5.3% of eligible residences redeemed KI vouchers. Most surveyed residents (76.5%) were aware of living near an NPP, yet 42.5% reported doing "nothing" to plan for an emergency. Almost half of surveyed voucher users did not know when to take KI or which body part KI protects. Among voucher nonusers, 48.0% were either unaware of the program or did not remember receiving a voucher. Additional efforts are needed to ensure that all residents are aware of the availability of KI and that recipients of the drug understand when and why it should be taken. Minimal emergency planning among residents living near Michigan's NPPs emphasizes the need for increased emergency preparedness and awareness. Findings are particularly salient given the March 2011 Fukushima Daiichi Nuclear Power Plant emergency in Japan.

  3. Study of the behaviour of transuranics and possible chemical homologues in Lake Michigan water and biota

    International Nuclear Information System (INIS)

    Wahlgren, M.A.; Alberts, J.J.; Nelson, D.M.; Orlandini, K.A.

    1976-01-01

    Concentration factors for Pu, Am and U in Lake Michigan biota are compared to those of a number of stable trace elements that have short residence times in Lake Michigan water. The relative order of uptake for these nuclides in Lake Michigan biota is Am>Pu much>U. Evidence is summarized which suggests that the predominant oxidation state of 239 , 240 Pu in Lake Michigan water is 4+. Concentrations of 239 , 240 Pu in net plankton, filterable particulate matter, sediment trap, and benthic floc samples indicate that sorption by biogenic detritus, and settling of this material, can account for the reduced concentration of 239 , 240 Pu observed in surface waters during summer stratification, but that deposition into the sediments is primarily non-biological. Concentrations of 7 Be, 144 Ce and 137 Cs in sediment trap samples show the effect of spring convective mixing and demonstrate the resuspension of mineral-rich surficial sediments during the summer months. The effect on the concentration of dissolved plutonium in the water column, of varying degrees of resuspension of sedimentary floc, is described using a simple mass-action model. A radiochemical method for the determination of americium and uranium in Lake Michigan environmental samples is also presented. (author)

  4. Outbreak of cryptosporidiosis associated with a firefighting response - Indiana and Michigan, June 2011.

    Science.gov (United States)

    2012-03-09

    On June 20, 2011, the Indiana Department of Homeland Security notified the Indiana State Department of Health (ISDH) of an Indiana fire station that reported gastrointestinal illness among a substantial percentage of their workers, causing missed workdays and one hospitalization as a result of cryptosporidiosis. All ill firefighters had responded to a barn fire in Michigan, 15 miles from the Michigan-Indiana border on June 6; responding firefighters from Michigan also had become ill. ISDH immediately contacted the Michigan Department of Community Health (MDCH) concerning this outbreak. The investigation was led by MDCH in partnership with ISDH and the Michigan local health department (LHD). Among 34 firefighters who responded to the fire, 33 were interviewed, and 20 (61%) reported gastrointestinal illness ≤12 days after the fire. Cryptosporidium parvum was identified in human stool specimens, calf fecal samples, and a swimming pond. Based on these findings, the following public health recommendations were issued: 1) discontinue swimming in the pond, 2) practice thorough hygiene to reduce fecal contamination and fecal-oral exposures, and 3) decontaminate firefighting equipment properly. No additional primary or secondary cases associated with this exposure have been reported. The findings highlight a novel work-related disease exposure for firefighters and the need for public education regarding cryptosporidiosis prevention.

  5. 76 FR 3569 - Proposed Amendment of Class E Airspace; West Yellowstone, MT

    Science.gov (United States)

    2011-01-20

    ... accommodate aircraft using the Instrument Landing System (ILS) Localizer (LOC) standard instrument approach... airspace areas extending upward from 700 feet or more above the surface of the earth. * * * * * ANM MT E5...

  6. mtDNA point and length heteroplasmy in high- and low radiation areas of Kerala

    International Nuclear Information System (INIS)

    Forster, L.; Forster, P.; Gurney, S.M.; Spencer, M.; Huang, C.; Röhl, A.; Brinkmann, B.

    2010-01-01

    A coastal peninsula in Kerala (India) contains the world's highest level of natural radioactivity in a densely populated area, offering an opportunity to characterize radiation-associated DNA mutations. Here, we focus on mitochondrial DNA (mtDNA) mutations, which are passed exclusively from the mother to her children. To analyse point mutations, we sampled 248 pedigrees (988 individuals) in the high-radiation peninsula and in nearby low-radiation islands as a control population. Then, in an extended sample of 1,172 mtDNA sequences (containing some non-Indians for comparison), we also analysed length mutations, which in mtDNA can lead to the phenomenon of length heteroplasmy, i.e. the existence of different DNA types in the same cell. We wished to find out how fast mtDNA mutates between generations, and whether the mutation rate is increased in radioactive conditions compared to the low-irradiation sample

  7. The size distribution of 210Po in the atmosphere around Mt. Sakurajima in Kagoshima prefecture, Japan

    International Nuclear Information System (INIS)

    Ashikawa, N.; Matsuoka, N.; Takashima, Y.; Syojo, N.; Imamura, H.; Fujisaki, M.

    1998-01-01

    The concentration and size distribution of 210 Po in particulate matters in the atmosphere were measured around the active volcano, Mt. Sakurajima in Kagoshima prefecture, Japan. The samples were collected eight times at four sampling points for the period from June 1994 to January 1996. The highest concentration of 210 Po was 2940 μBq/m 3 at Akamizu located 2 km away from the crater of Mt. Sakurajima. The 210 Po concentrations decreased with the increase of distance form Mt. Sakurajima. The size distribution curves of 210 Po in the particulate matters showed that 210 Po is usually condensed to fine particles smaller than 2 μm in diameter. In addition, it was suggested that the 210 Po concentration in particulate matters collected at Akamizu was affected by the wind direction over Mt. Sakurajima. (author)

  8. Applicability of Daily Solar Radiation Estimated by Mountain Microclimate Simulation Model (MT-CLIM) in Korea

    International Nuclear Information System (INIS)

    Shim, K.M.; Kim, Y.S.; Lee, D.B.; Kang, K.K.; So, K.H.

    2012-01-01

    Accuracy of daily solar radiation estimated from a Mountain Microclimate Simulation Model (MT-CLIM) was assessed for seven observation sites with complex topography in Uiseong County. The coefficient of determination () between the observed and the estimated daily solar radiation was 0.52 for 7 sites for the study period from 1 August to 30 September 2009. Overall, the MT-CLIM overestimated the solar radiation with root mean square error (RMSE) of which is about 25% of the mean daily solar radiation () for the study period. Considering that the pyranometer's tolerance is of standard sensor, the RMSE of MT-CLIM was too large to accept for a direct application for agricultural sector. The reliability of solar radiation estimated by MT-CLIM must be improved by considering additional ways such as using a topography correction coefficient

  9. Expression of the rgMT gene, encoding for a rice metallothionein ...

    Indian Academy of Sciences (India)

    the rice rgMT gene in transgenic yeast and Arabidopsis is implicated in improving their tolerance for .... possible by the use of a microscope with UV optics that ... Abiotic stress factors that induced the expression of the ..... Arabidopsis mutant.

  10. Synthetic Modeling of A Geothermal System Using Audio-magnetotelluric (AMT) and Magnetotelluric (MT)

    Science.gov (United States)

    Mega Saputra, Rifki; Widodo

    2017-04-01

    Indonesia has 40% of the world’s potential geothermal resources with estimated capacity of 28,910 MW. Generally, the characteristic of the geothermal system in Indonesia is liquid-dominated systems, which driven by volcanic activities. In geothermal exploration, electromagnetic methods are used to map structures that could host potential reservoirs and source rocks. We want to know the responses of a geothermal system using synthetic data of Audio-magnetotelluric (AMT) and Magnetotelluric (MT). Due to frequency range, AMT and MT data can resolve the shallow and deeper structure, respectively. 1-D models have been performed using AMT and MT data. The results indicate that AMT and MT data give detailed conductivity distribution of geothermal structure.

  11. Mitochondrial DNA (mtDNA haplogroups in 1526 unrelated individuals from 11 Departments of Colombia

    Directory of Open Access Journals (Sweden)

    Juan J. Yunis

    2013-01-01

    Full Text Available The frequencies of four mitochondrial Native American DNA haplogroups were determined in 1526 unrelated individuals from 11 Departments of Colombia and compared to the frequencies previously obtained for Amerindian and Afro-Colombian populations. Amerindian mtDNA haplogroups ranged from 74% to 97%. The lowest frequencies were found in Departments on the Caribbean coast and in the Pacific region, where the frequency of Afro-Colombians is higher, while the highest mtDNA Amerindian haplogroup frequencies were found in Departments that historically have a strong Amerindian heritage. Interestingly, all four mtDNA haplogroups were found in all Departments, in contrast to the complete absence of haplogroup D and high frequencies of haplogroup A in Amerindian populations in the Caribbean region of Colombia. Our results indicate that all four Native American mtDNA haplogroups were widely distributed in Colombia at the time of the Spanish conquest.

  12. A collaborative EDNAP exercise on SNaPshot™-based mtDNA control region typing

    DEFF Research Database (Denmark)

    Weiler, NEC; Baca, K; Ballard, D

    2017-01-01

    A collaborative European DNA Profiling (EDNAP) Group exercise was undertaken to assess the performance of an earlier described SNaPshot™-based screening assay (denoted mini-mtSNaPshot) (Weiler et al., 2016) [1] that targets 18 single nucleotide polymorphism (SNP) positions in the mitochondrial (m...... and derived from a subset of the participants, indicating a need for training and guidelines regarding mini-mtSNaPshot data interpretation....

  13. MT-ComparEval: Graphical evaluation interface for Machine Translation development

    Directory of Open Access Journals (Sweden)

    Klejch Ondřej

    2015-10-01

    Full Text Available The tool described in this article has been designed to help MT developers by implementing a web-based graphical user interface that allows to systematically compare and evaluate various MT engines/experiments using comparative analysis via automatic measures and statistics. The evaluation panel provides graphs, tests for statistical significance and n-gram statistics. We also present a demo server http://wmt.ufal.cz with WMT14 and WMT15 translations.

  14. Metallothionein (MT) response after chronic palladium exposure in the zebra mussel, Dreissena polymorpha

    International Nuclear Information System (INIS)

    Frank, Sabrina N.; Singer, Christoph; Sures, Bernd

    2008-01-01

    The effects of different exposure concentrations of palladium (Pd) on relative metallothionein (MT) response and bioaccumulation were investigated in zebra mussels (Dreissena polymorpha). The mussels were exposed to 0.05, 5, 50, and 500 μg/L Pd 2+ for 10 weeks under controlled temperature and fasting conditions. Relative MT contents were assessed by a modified Ag-saturation method, which allows to discriminate between MT bound to Pd (Pd-MT) and MT bound to unidentified metals (Ag-MT). Determination of metal contents resulted from atomic absorption spectrometry following a microwave digestion. For unexposed mussels and mussels exposed to 0.05 μg/L Pd no metal accumulation could be detected. All other exposure concentrations resulted in detectable Pd accumulation in mussels with final tissue concentrations of 96 μg/g (500 μg/L), 45 μg/g (50 μg/L), and 9 μg/g (5 μg/L). Compared with initial levels Pd-MT concentrations at the end of the exposure period were 600 (500 μg/L), 160 (50 μg/L), and 27 (5 μg/L) times higher. These results show that an increase in MTs in D. polymorpha already occurs at relatively low aqueous Pd concentrations indicating that there is the need for detoxification of Pd in the mussel. Furthermore, correlations between Ag-MT and Pd accumulation indicate that higher exposure concentrations are associated with adverse effects on the mussels. Thus, harmful effects of chronic Pd exposure of organisms even in lowest concentrations cannot be excluded in the environment

  15. Shell-free biomass and population dynamics of dreissenids in offshore Lake Michigan, 2001-2003

    Science.gov (United States)

    French, J. R. P.; Adams, J.V.; Craig, J.; Stickel, R.G.; Nichols, S.J.; Fleischer, G.W.

    2007-01-01

    The USGS-Great Lakes Science Center has collected dreissenid mussels annually from Lake Michigan since zebra mussels (Dreissena polymorpha) became a significant portion of the bottom-trawl catch in 1999. For this study, we investigated dreissenid distribution, body mass, and recruitment at different depths in Lake Michigan during 2001-2003. The highest densities of dreissenid biomass were observed from depths of 27 to 46 m. The biomass of quagga mussels (Dreissena bugensis) increased exponentially during 2001-2003, while that of zebra mussels did not change significantly. Body mass (standardized for a given shell length) of both species was lowest from depths of 27 to 37m, highest from 55 to 64 m, and declined linearly at deeper depths during 2001-2003. Recruitment in 2003, as characterized by the proportion of mussels biomass in Lake Michigan.

  16. Enhancing Michigan's local public health accreditation program through participation in the multistate learning collaborative.

    Science.gov (United States)

    Kushion, Mary L; Tews, Debra Scamarcia; Parker, Melody D

    2007-01-01

    This article presents Michigan's efforts and accomplishments as a result of its involvement with the Multi-State Learning Collaborative (MLC) project. The article gives a brief overview of Michigan's accreditation program. It outlines the two goals and six objectives associated with Michigan's MLC project, and describes the structure it used to implement the project plan. It further explains and illustrates the outcomes achieved from successfully meeting the goals and objectives. The article gives a sample of a proposed voluntary component for continuous quality improvement that local health departments can implement utilizing the Shewhart Cycle of "Plan, Do, Check, and Act" and National Association of City and County Health Officials' Operational Definition of a Functional Health Department.

  17. Descriptive Epidemiology of Bovine Tuberculosis in Michigan (1975–2010: Lessons Learned

    Directory of Open Access Journals (Sweden)

    Chika C. Okafor

    2011-01-01

    Full Text Available Despite ongoing eradication efforts, bovine tuberculosis (BTB remains a challenge in Michigan livestock and wildlife. The objectives of this study were to (1 review the epidemiology of BTB in Michigan cattle, privately owned cervids, and wildlife between 1975 and 2010 and (2 identify important lessons learned from the review and eradication strategies. BTB information was accessed from the Michigan BTB Eradication Project agencies. Cattle herds (49, privately owned deer herds (4, and wild white-tailed deer (668 were found infected with BTB during the review period. BTB has occurred primarily in counties located at the northern portion of the state's Lower Peninsula. Currently used BTB eradication strategies have successfully controlled BTB spread. However additional changes in BTB surveillance, prevention, and eradication strategies could improve eradication efforts.

  18. 33 CFR 334.840 - Waters of Lake Michigan south of Northerly Island at entrance to Burnham Park Yacht Harbor...

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Waters of Lake Michigan south of Northerly Island at entrance to Burnham Park Yacht Harbor, Chicago, Ill.; danger zone adjacent to airport on... Michigan south of Northerly Island at entrance to Burnham Park Yacht Harbor, Chicago, Ill.; danger zone...

  19. 76 FR 78161 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2011-12-16

    ... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... INFORMATION: The Coast Guard will enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake...

  20. 76 FR 35106 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2011-06-16

    ...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago..., DHS. ACTION: Final rule. SUMMARY: The Coast Guard is establishing a permanent safety zone from Brandon... Safety Zones; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary...

  1. 77 FR 25595 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2012-05-01

    ... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... Safety Zone; Brandon Road Lock and [[Page 25596

  2. Modeling the Sensitivity of Primary Production in Lake Michigan to Nutrient Loads with and without Dreissenid Mussels

    Science.gov (United States)

    Dreissenid (quagga) mussels became established in large numbers in Lake Michigan beginning around 2004. Since then, significant changes have been observed in Lake Michigan open-water chlorophyll and nutrient concentrations, and in primary production. We updated the LM3-Eutro mode...

  3. 76 FR 65609 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

    Science.gov (United States)

    2011-10-24

    ... Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship Canal... Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal, Chicago... INFORMATION: The Coast Guard will enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake...

  4. Reaction to "Observations on School District and Service Consolidation in Michigan." Working Paper #17 by David Arsen. Working Paper #18

    Science.gov (United States)

    Shakrani, Sharif M.

    2011-01-01

    The author's "School District Consolidation Study in 10 Michigan Counties" study was published in August, 2010 by The Education Policy Center at Michigan State University. It was intended to measure the financial impact of consolidation of schools at the county level akin to other states like Virginia, Florida and Maryland. The study was…

  5. Michigan forest ecosystem vulnerability assessment and synthesis: a report from the Northwoods Climate Change Response Framework project

    Science.gov (United States)

    Stephen Handler; Matthew J. Duveneck; Louis Iverson; Emily Peters; Robert M. Scheller; Kirk R. Wythers; Leslie Brandt; Patricia Butler; Maria Janowiak; P. Danielle Shannon; Chris Swanston; Amy Clark Eagle; Joshua G. Cohen; Rich Corner; Peter B. Reich; Tim Baker; Sophan Chhin; Eric Clark; David Fehringer; Jon Fosgitt; James Gries; Christine Hall; Kimberly R. Hall; Robert Heyd; Christopher L. Hoving; Ines Ibáñez; Don Kuhr; Stephen Matthews; Jennifer Muladore; Knute Nadelhoffer; David Neumann; Matthew Peters; Anantha Prasad; Matt Sands; Randy Swaty; Leiloni Wonch; Jad Daley; Mae Davenport; Marla R. Emery; Gary Johnson; Lucinda Johnson; David Neitzel; Adena Rissman; Chadwick Rittenhouse; Robert. Ziel

    2014-01-01

    Forests in northern Michigan will be affected directly and indirectly by a changing climate during the next 100 years. This assessment evaluates the vulnerability of forest ecosystems in Michigan's eastern Upper Peninsula and northern Lower Peninsula to a range of future climates. Information on current forest conditions, observed climate trends, projected climate...

  6. 77 FR 30315 - Notice of Intent To Amend the 1985 Michigan Resource Management Plan and Associated Environmental...

    Science.gov (United States)

    2012-05-22

    ... may submit comments on issues and planning criteria related to the 1985 Michigan RMP Amendment by any... the deaf (TDD) may call the Federal Information Relay Service (FIRS) at 1- 800-877-8339 to contact the... Michigan RMP, announces the beginning of the scoping process, and seeks public input on issues and planning...

  7. 77 FR 11426 - Safety Zones; Annual Events Requiring Safety Zones in the Captain of the Port Lake Michigan Zone

    Science.gov (United States)

    2012-02-27

    ... Memorial Day; 8:30 p.m. to 10 p.m. (6) Michigan Super Boat Grand Prix; Michigan City, IN. (i) Location. All....m. to 11 p.m. (9) Harborfest Music and Family Festival; Racine, WI. (i) Location. All waters of Lake...

  8. Hydrothermal Alteration of the Mt Unzen Conduit (Shimabara/Japan)

    Science.gov (United States)

    Yilmaz, T. I.; Mayer, K.; Hess, K. U.; Janots, E.; Gilg, H. A.; Dingwell, D. B.

    2016-12-01

    Investigations were carried out on hydrothermally altered coherent dacitic dykes samples from (USDP-4) drill core at Mt Unzen stratovolcano (Shimabara/Japan). XRF, XRD, EMPA, and C-O-isotope analysis led to insights concerning chemistry, mineralogy, and intensity of alteration as well as the origin of carbonate-precipitating fluids. Additionally a textural characterization of the occurring replacement features in the magma conduit zone was performed. The occurrence of the main secondary phases such as chlorite, pyrite, carbonates, and R1 (Reichweite parameter) illite-smectite indicate a weak to moderate propylitic to phyllic hydrothermal alteration. The dacitic samples of the dykes show different hydrothermal alteration features: (i) carbonate pseudomorphs after hornblende as well as core and zonal textures due to replacement of plagioclase by R1 illite-smectite, (ii) colloform banded fracture fillings and fillings in dissolution vugs, and (iii) chlorite and R1 illite-smectite in the groundmass. Carbonates in fractures comprise iron-rich dolomite solid solutions ("ankerite") and calcite. Isotopic values of d13Cvpdb = -4.59 ± 0.6‰ and d18Ovpdb = -21.73 ± 0.5‰ indicate a hydrothermal-magmatic origin for the carbonate formation. The chlorite-carbonate-pyrite index (CCPI) and the Ishikawa alteration index (AI), applied to the investigated samples show significant differences (CCPI=52.7-57.8; AI=36.1-40.6) indicating their different degree of alteration. According to Nakada et al., 2005, the C13 to C16 dykes represent the feeder dyke from the latest eruption (1991-1995) whereas C8 represents an earlier dyke feeder dyke from an older eruption. Weakest conduit alteration, which was obtained in samples C16-1-5 and C13-2-5, correlates with the alteration degree of the pristine dome rocks. Highest CCPI value was determined for sample C14-1-5 and the highest AI value was determined for sample C15-2-6. The degrees of alteration do not indicate highest alteration of the

  9. Clast comminution during pyroclastic density current transport: Mt St Helens

    Science.gov (United States)

    Dawson, B.; Brand, B. D.; Dufek, J.

    2011-12-01

    Volcanic clasts within pyroclastic density currents (PDCs) tend to be more rounded than those in fall deposits. This rounding reflects degrees of comminution during transport, which produces an increase in fine-grained ash with distance from source (Manga, M., Patel, A., Dufek., J. 2011. Bull Volcanol 73: 321-333). The amount of ash produced due to comminution can potentially affect runout distance, deposit sorting, the volume of ash lofted into the upper atmosphere, and increase internal pore pressure (e.g., Wohletz, K., Sheridan, M. F., Brown, W.K. 1989. J Geophy Res, 94, 15703-15721). For example, increased pore pressure has been shown to produce longer runout distances than non-comminuted PDC flows (e.g., Dufek, J., and M. Manga, 2008. J. Geophy Res, 113). We build on the work of Manga et al., (2011) by completing a pumice abrasion study for two well-exposed flow units from the May 18th, 1980 eruption of Mt St Helens (MSH). To quantify differences in comminution from source, sampling and the image analysis technique developed in Manga et al., 2010 was completed at distances proximal, medial, and distal from source. Within the units observed, data was taken from the base, middle, and pumice lobes within the outcrops. Our study is unique in that in addition to quantifying the degree of pumice rounding with distance from source, we also determine the possible range of ash sizes produced during comminution by analyzing bubble wall thickness of the pumice through petrographic and SEM analysis. The proportion of this ash size is then measured relative to the grain size of larger ash with distance from source. This allows us to correlate ash production with degree of rounding with distance from source, and determine the fraction of the fine ash produced due to comminution versus vent-fragmentation mechanisms. In addition we test the error in 2D analysis by completing a 3D image analysis of selected pumice samples using a Camsizer. We find that the roundness of PDC

  10. Data Mining in the Context of Monitoring Mt Etna, Italy

    Science.gov (United States)

    Aliotta, Marco; Cassisi, Carmelo; D'Agostino, Marcello; Falsaperla, Susanna; Ferrari, Ferruccio; Langer, Horst; Messina, Alfio; Montalto, Placido; Reitano, Danilo; Spampinato, Salvatore

    2015-04-01

    The persistent volcanic activity of Mt Etna makes the continuous monitoring of multidisciplinary data a first-class issue. Indeed, the monitoring systems rapidly accumulate huge quantity of data, arising specific problems of andling and interpretation. In order to respond to these problems, the INGV staff has developed a number of software tools for data mining. These tools have the scope of identifying structures in the data that can be related to volcanic activity, furnishing criteria for the identification of precursory scenarios. In particular, we use methods of clustering and classification in which data are divided into groups according to a-priori-defined measures of similarity or distance. Data groups may assume various shapes, such as convex clouds or complex concave bodies.The "KKAnalysis" software package is a basket of clustering methods. Currently, it is one of the key techniques of the tremor-based automatic alarm systems of INGV Osservatorio Etneo. It exploits both Self-Organizing Maps and Fuzzy Clustering. Beside seismic data, the software has been applied to the geochemical composition of eruptive products as well as a combined analysis of gas-emission (radon) and seismic data. The "DBSCAN" package exploits a concept based on density-based clustering. This method allows discovering clusters with arbitrary shape. Clusters are defined as dense regions of objects in the data space separated by regions of low density. In DBSCAN a cluster grows as long as the density within a group of objects exceeds some threshold. In the context of volcano monitoring, the method is particularly promising in the recognition of ash particles as they have a rather irregular shape. The "MOTIF" software allows us to identify typical waveforms in time series, outperforming methods like cross-correlation that entail a high computational effort. MOTIF can recognize the non-imilarity of two patterns on a small number of data points without going through the whole length of

  11. Chuva de sementes em remanescentes florestais de Campo Verde, MT

    Directory of Open Access Journals (Sweden)

    William Pietro-Souza

    2014-08-01

    Full Text Available O objetivo deste trabalho consistiu em avaliar sazonalmente a produção de sementes provenientes de fragmentos florestais presentes na zona rural de Campo Verde, MT. Essa caracterização ocorreu em termos de produção de sementes e riqueza de espécies vegetais. Foram selecionados três fragmentos florestais caracterizados como Floresta Estacional Semidecidual. Em cada fragmento, cinco coletores foram instalados e confeccionados com canos de PVC (1 m²; malha de náilon de 0,001 m e 0,15 m de profundidade do bojo. O material foi coletado mensalmente, cujas sementes foram quantificadas e separadas conforme a síndrome de dispersão, etapa sucessional e forma de vida. Houve a determinação da densidade, frequência absoluta, índice de diversidade e equitabilidade. Ao todo, foram obtidas 3.622 sementes, pertencentes a 74 táxons. Maiores densidades de sementes foram observadas durante os meses de setembro, outubro e novembro. As lianas Gouania sp., Fridericia speciosa, Heteropterys sp. e Distictella sp. responderam com 55,95% do total de sementes aportadas. Das espécies que compuseram a chuva de sementes, 74% não são dispersas pelo vento. Todavia, quando se verificou a quantidade de diásporos coletados, formas dispersas pelo vento foram predominantes, representando 76% do total. Citam-se como táxons arbóreos importantes para a recomposição florestal na região de Campo Verde, situada no Sudeste de Mato Grosso: Tachigali rubiginosa, Siparuna guianensis, Nectandra sp., Cordia alliodora, Alibertia sp., Terminalia brasiliensis e Myrcia sp. Essas espécies devem ser alvo de estudos mais específicos relacionados ao seu potencial para recuperação de ambientes degradados, considerando-se as Áreas de Preservação Permanente e Reservas Legais.

  12. Cloud chemistry in eastern China: Observations from Mt. Tai

    Science.gov (United States)

    Collett, J. L.; Shen, X.; Lee, T.; Wang, X.; Li, Y.; Wang, W.; Wang, T.

    2010-07-01

    Until recently, studies of fog and cloud chemistry in China have been rare - even though the fate of China’s large sulfur dioxide emissions depends, in part, on the ability of regional clouds to support rapid aqueous oxidation to sulfate. Sulfur dioxide oxidized in regional clouds is more likely to be removed by wet deposition while sulfur dioxide that undergoes slower gas phase oxidation is expected to survive longer in the atmosphere and be transported over a much broader spatial scale. Two 2008 field campaigns conducted at Mt. Tai, an isolated peak on the NE China plain, provide insight into the chemical composition of regional clouds and the importance of various aqueous phase sulfur oxidation pathways. Single and two-stage Caltech Active Strand Cloudwater Collectors were used to collect bulk and drop size-resolved samples of cloudwater. Collected cloudwater was analyzed for key species that influence in-cloud sulfate production, including pH, S(IV), H2O2, Fe and Mn. Other major cloud solutes, including inorganic ions, total organic carbon (TOC), formaldehyde, and organic acids were also analyzed, as were gas phase concentrations of SO2, O3, and H2O2. A wide range of cloud pH was observed, from below 3 to above 6. High concentrations of cloudwater sulfate were consistent with abundant sulfur dioxide emissions in the region. Sampled clouds were also found to contain high concentrations of ammonium, nitrate, and organic carbon. Peak TOC concentrations reached approximately 200 ppmC, among the highest concentrations ever measured in cloudwater. Hydrogen peroxide was found to be the dominant aqueous phase S(IV) oxidant when cloud pH was less than approximately 5.4. Despite its fast reaction with sulfur dioxide in cloud droplets, high concentrations of residual hydrogen peroxide were measured in some clouds implying a substantial additional capacity for sulfate production. Ozone was found to be an important S(IV) oxidant when cloud pH was high. Oxidation of S

  13. Thermodynamics of Pb(ii) and Zn(ii) binding to MT-3, a neurologically important metallothionein.

    Science.gov (United States)

    Carpenter, M C; Shami Shah, A; DeSilva, S; Gleaton, A; Su, A; Goundie, B; Croteau, M L; Stevenson, M J; Wilcox, D E; Austin, R N

    2016-06-01

    Isothermal titration calorimetry (ITC) was used to quantify the thermodynamics of Pb(2+) and Zn(2+) binding to metallothionein-3 (MT-3). Pb(2+) binds to zinc-replete Zn7MT-3 displacing each zinc ion with a similar change in free energy (ΔG) and enthalpy (ΔH). EDTA chelation measurements of Zn7MT-3 and Pb7MT-3 reveal that both metal ions are extracted in a tri-phasic process, indicating that they bind to the protein in three populations with different binding thermodynamics. Metal binding is entropically favoured, with an enthalpic penalty that reflects the enthalpic cost of cysteine deprotonation accompanying thiolate ligation of the metal ions. These data indicate that Pb(2+) binding to both apo MT-3 and Zn7MT-3 is thermodynamically favourable, and implicate MT-3 in neuronal lead biochemistry.

  14. The Current State and Historico-geographical Background of Mt. Chirisan Region Immigrants

    Directory of Open Access Journals (Sweden)

    Sungho Kang

    2016-08-01

    Full Text Available This paper examined the historico-geographical background and current state of immigrants in the area designated as the “Mt. Chirisan Region,” their characteristics, and related integration issues. This article defines the Mt. Chirisan Region as the 7 cities/kuns of Namwŏn-si, Changsu-kun, Koksŏng-kun, Kurye-kun, Hadong-kun, Sanchŏng-kun, and Hamyang-kun. As the Mt. Chirisan Region mainly consists of mountainous and agricultural areas, the immigrant induction effect socio-economically was low relative to urban and industrial areas. It was also noted that, as the percentage of marriage immigration in Mt. Chirisan was high relative to urban or industrial areas, the female foreigner ratio was higher than that of male foreigners. In regard to the home countries of immigrants, women from South-East Asia and North-East Asia accounted for the majority. Also, this article examines the current situation of support programs of 7 local Multicultural Family Support Centers in the Mt. Chirisan Region, their problems, and probably solutions. Based on the historical development of the region and recent social changes, our society and government need to actively develop a higher level of social integration and employment education support programs, and carry out policies that will protect the diverse cultural identities of immigrants. In addition, differentiated multicultural family support programs appropriate for Mt. Chirisan, an inland mountain region, need to be developed.

  15. Biochemical signatures mimicking multiple carboxylase deficiency in children with mutations in MT-ATP6.

    Science.gov (United States)

    Larson, Austin A; Balasubramaniam, Shanti; Christodoulou, John; Burrage, Lindsay C; Marom, Ronit; Graham, Brett H; Diaz, George A; Glamuzina, Emma; Hauser, Natalie; Heese, Bryce; Horvath, Gabriella; Mattman, Andre; van Karnebeek, Clara; Lane Rutledge, S; Williamson, Amy; Estrella, Lissette; Van Hove, Johan K L; Weisfeld-Adams, James D

    2018-01-04

    Elevations of specific acylcarnitines in blood reflect carboxylase deficiencies, and have utility in newborn screening for life-threatening organic acidemias and other inherited metabolic diseases. In this report, we describe a newly-identified association of biochemical features of multiple carboxylase deficiency in individuals harboring mitochondrial DNA (mtDNA) mutations in MT-ATP6 and in whom organic acidemias and multiple carboxylase deficiencies were excluded. Using retrospective chart review, we identified eleven individuals with abnormally elevated propionylcarnitine (C3) or hydroxyisovalerylcarnitine (C5OH) with mutations in MT-ATP6, most commonly m.8993T>G in high heteroplasmy or homoplasmy. Most patients were ascertained on newborn screening; most had normal enzymatic or molecular genetic testing to exclude biotinidase and holocarboxylase synthetase deficiencies. MT-ATP6 is associated with some cases of Leigh disease; clinical outcomes in our cohort ranged from death from neurodegenerative disease in early childhood to clinically and developmentally normal after several years of follow-up. These cases expand the biochemical phenotype associated with MT-ATP6 mutations, especially m.8993T>G, to include acylcarnitine abnormalities mimicking carboxylase deficiency states. Clinicians should be aware of this association and its implications for newborn screening, and consider mtDNA sequencing in patients exhibiting similar acylcarnitine abnormalities that are biotin-unresponsive and in whom other enzymatic deficiencies have been excluded. Copyright © 2018 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

  16. Geant4-MT: bringing multi-threading into Geant4 production

    International Nuclear Information System (INIS)

    Ahn, S.; Apostolakis, J.; Cosmo, G.; Nowak, A.; Asai, M.; Brandt, D.; Dotti, A.; Coopermann, G.; Dong, X.; Jun, Soon Yung

    2013-01-01

    Geant4-MT is the multi-threaded version of the Geant4 particle transport code. The key goals for the design of Geant4-MT have been a) the need to reduce the memory footprint of the multi-threaded application compared to the use of separate jobs and processes; b) to create an easy migration of the existing applications; and c) to use efficiently many threads or cores, by scaling up to tens and potentially hundreds of workers. The first public release of a Geant4- MT prototype was made in 2011. We report on the revision of Geant4-MT for inclusion in the production-level release scheduled for end of 2013. This has involved significant re-engineering of the prototype in order to incorporate it into the main Geant4 development line, and the porting of Geant4-MT threading code to additional platforms. In order to make the porting of applications as simple as possible, refinements addressed the needs of standalone applications. Further adaptations were created to improve the fit with the frameworks of High Energy Physics experiments. We report on performances measurements on Intel Xeon TM , AMD Opteron TM the first trials of Geant4-MT on the Intel Many Integrated Cores (MIC) architecture, in the form of the Xeon Phi TM co-processor. These indicate near-linear scaling through about 200 threads on 60 cores, when holding fixed the number of events per thread. (authors)

  17. Mitochondrial depolarization in yeast zygotes inhibits clonal expansion of selfish mtDNA.

    Science.gov (United States)

    Karavaeva, Iuliia E; Golyshev, Sergey A; Smirnova, Ekaterina A; Sokolov, Svyatoslav S; Severin, Fedor F; Knorre, Dmitry A

    2017-04-01

    Non-identical copies of mitochondrial DNA (mtDNA) compete with each other within a cell and the ultimate variant of mtDNA present depends on their relative replication rates. Using yeast Saccharomyces cerevisiae cells as a model, we studied the effects of mitochondrial inhibitors on the competition between wild-type mtDNA and mutant selfish mtDNA in heteroplasmic zygotes. We found that decreasing mitochondrial transmembrane potential by adding uncouplers or valinomycin changes the competition outcomes in favor of the wild-type mtDNA. This effect was significantly lower in cells with disrupted mitochondria fission or repression of the autophagy-related genes ATG8 , ATG32 or ATG33 , implying that heteroplasmic zygotes activate mitochondrial degradation in response to the depolarization. Moreover, the rate of mitochondrially targeted GFP turnover was higher in zygotes treated with uncoupler than in haploid cells or untreated zygotes. Finally, we showed that vacuoles of zygotes with uncoupler-activated autophagy contained DNA. Taken together, our data demonstrate that mitochondrial depolarization inhibits clonal expansion of selfish mtDNA and this effect depends on mitochondrial fission and autophagy. These observations suggest an activation of mitochondria quality control mechanisms in heteroplasmic yeast zygotes. © 2017. Published by The Company of Biologists Ltd.

  18. Strengthening MT6D Defenses with LXC-Based Honeypot Capabilities

    Directory of Open Access Journals (Sweden)

    Dileep Basam

    2016-01-01

    Full Text Available Moving Target IPv6 Defense (MT6D imparts radio-frequency hopping behavior to IPv6 networks by having participating nodes periodically hop onto new addresses while giving up old addresses. Our previous research efforts implemented a solution to identify and acquire these old addresses that are being discarded by MT6D hosts on a local network besides being able to monitor and visualize the incoming traffic on these addresses. This was essentially equivalent to forming a darknet out of the discarded MT6D addresses, but the solution presented in the previous research effort did not include database integration for it to scale and be extended. This paper presents a solution with a new architecture that not only extends the previous solution in terms of automation and database integration but also demonstrates the ability to deploy a honeypot on a virtual LXC (Linux Container on-demand based on any interesting traffic pattern observed on a discarded address. The proposed architecture also allows an MT6D host to query the solution database for network activity on its relinquished addresses as a JavaScript Object Notation (JSON object. This allows an MT6D host to identify suspicious activity on its discarded addresses and strengthen the MT6D scheme parameters accordingly. We have built a proof-of-concept for the proposed solution and analyzed the solution’s feasibility and scalability.

  19. Random mtDNA mutations modulate proliferation capacity in mouse embryonic fibroblasts

    International Nuclear Information System (INIS)

    Kukat, Alexandra; Edgar, Daniel; Bratic, Ivana; Maiti, Priyanka; Trifunovic, Aleksandra

    2011-01-01

    Highlights: → Increased mtDNA mutations in MEFs lead to high level of spontaneous immortalization. → This process is independent of endogenous ROS production. → Aerobic glycolysis significantly contributes to spontaneous immortalization of MEFs. -- Abstract: An increase in mtDNA mutation load leads to a loss of critical cells in different tissues thereby contributing to the physiological process of organismal ageing. Additionally, the accumulation of senescent cells that display changes in metabolic function might act in an active way to further disrupt the normal tissue function. We believe that this could be the important link missing in our understanding of the molecular mechanisms of premature ageing in the mtDNA mutator mice. We tested proliferation capacity of mtDNA mutator cells in vitro. When cultured in physiological levels of oxygen (3%) their proliferation capacity is somewhat lower than wild-type cells. Surprisingly, in conditions of increased oxidative stress (20% O 2 ) mtDNA mutator mouse embryonic fibroblasts exhibit continuous proliferation due to spontaneous immortalization, whereas the same conditions promote senescence in wild-type cells. We believe that an increase in aerobic glycolysis observed in mtDNA mutator mice is a major mechanism behind this process. We propose that glycolysis promotes proliferation and allows a fast turnover of metabolites, but also leads to energy crisis due to lower ATP production rate. This could lead to compromised replication and/or repair and therefore, in rare cases, might lead to mutations in tumor suppressor genes and spontaneous immortalization.

  20. Individual Variations in Inorganic Arsenic Metabolism Associated with AS3MT Genetic Polymorphisms

    Directory of Open Access Journals (Sweden)

    Haruo Takeshita

    2011-04-01

    Full Text Available Individual variations in inorganic arsenic metabolism may influence the toxic effects. Arsenic (+3 oxidation state methyltransferase (AS3MT that can catalyze the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet to trivalent arsenical, may play a role in arsenic metabolism in humans. Since the genetic polymorphisms of AS3MT gene may be associated with the susceptibility to inorganic arsenic toxicity, relationships of several single nucleotide polymorphisms (SNPs in AS3MT with inorganic arsenic metabolism have been investigated. Here, we summarize our recent findings and other previous studies on the inorganic arsenic metabolism and AS3MT genetic polymorphisms in humans. Results of genotype dependent differences in arsenic metabolism for most of SNPs in AS3MT were Inconsistent throughout the studies. Nevertheless, two SNPs, AS3MT 12390 (rs3740393 and 14458 (rs11191439 were consistently related to arsenic methylation regardless of the populations examined for the analysis. Thus, these SNPs may be useful indicators to predict the arsenic metabolism via methylation pathways.

  1. MT1-MMP-mediated basement membrane remodeling modulates renal development

    International Nuclear Information System (INIS)

    Riggins, Karen S.; Mernaugh, Glenda; Su, Yan; Quaranta, Vito; Koshikawa, Naohiko; Seiki, Motoharu; Pozzi, Ambra; Zent, Roy

    2010-01-01

    Extracellular matrix (ECM) remodeling regulates multiple cellular functions required for normal development and tissue repair. Matrix metalloproteinases (MMPs) are key mediators of this process and membrane targeted MMPs (MT-MMPs) in particular have been shown to be important in normal development of specific organs. In this study we investigated the role of MT1-MMP in kidney development. We demonstrate that loss of MT1-MMP leads to a renal phenotype characterized by a moderate decrease in ureteric bud branching morphogenesis and a severe proliferation defect. The kidneys of MT1-MMP-null mice have increased deposition of collagen IV, laminins, perlecan, and nidogen and the phenotype is independent of the MT-1MMP target, MMP-2. Utilizing in vitro systems we demonstrated that MTI-MMP proteolytic activity is required for renal tubule cells to proliferate in three dimensional matrices and to migrate on collagen IV and laminins. Together these data suggest an important role for MT1-MMP in kidney development, which is mediated by its ability to regulate cell proliferation and migration by proteolytically cleaving kidney basement membrane components.

  2. The amount and integrity of mtDNA in maize decline with development.

    Science.gov (United States)

    Oldenburg, Delene J; Kumar, Rachana A; Bendich, Arnold J

    2013-02-01

    In maize and other grasses there is a developmental gradient from the meristematic cells at the base of the stalk to the differentiated cells at the leaf tip. This gradient presents an opportunity to investigate changes in mitochondrial DNA (mtDNA) that accompany growth under light and dark conditions, as done previously for plastid DNA. Maize mtDNA was analyzed by DAPI-DNA staining of individual mitochondria, gel electrophoresis/blot hybridization, and real-time qPCR. Both the amount and integrity of the mtDNA were found to decline with development. There was a 20-fold decline in mtDNA copy number per cell from the embryo to the light-grown leaf blade. The amount of DNA per mitochondrial particle was greater in dark-grown leaf blade (24 copies, on average) than in the light (2 copies), with some mitochondria lacking any detectable DNA. Three factors that influence the demise of mtDNA during development are considered: (1) the decision to either repair or degrade mtDNA molecules that are damaged by the reactive oxygen species produced as byproducts of respiration; (2) the generation of ATP by photophosphorylation in chloroplasts, reducing the need for respiratory-competent mitochondria; and (3) the shift in mitochondrial function from energy-generating respiration to photorespiration during the transition from non-green to green tissue.

  3. No evidence of Neandertal mtDNA contribution to early modern humans.

    Directory of Open Access Journals (Sweden)

    David Serre

    2004-03-01

    Full Text Available The retrieval of mitochondrial DNA (mtDNA sequences from four Neandertal fossils from Germany, Russia, and Croatia has demonstrated that these individuals carried closely related mtDNAs that are not found among current humans. However, these results do not definitively resolve the question of a possible Neandertal contribution to the gene pool of modern humans since such a contribution might have been erased by genetic drift or by the continuous influx of modern human DNA into the Neandertal gene pool. A further concern is that if some Neandertals carried mtDNA sequences similar to contemporaneous humans, such sequences may be erroneously regarded as modern contaminations when retrieved from fossils. Here we address these issues by the analysis of 24 Neandertal and 40 early modern human remains. The biomolecular preservation of four Neandertals and of five early modern humans was good enough to suggest the preservation of DNA. All four Neandertals yielded mtDNA sequences similar to those previously determined from Neandertal individuals, whereas none of the five early modern humans contained such mtDNA sequences. In combination with current mtDNA data, this excludes any large genetic contribution by Neandertals to early modern humans, but does not rule out the possibility of a smaller contribution.

  4. Automatic Grader of MT Outputs in Colloquial Style by Using Multiple Edit Distances

    Science.gov (United States)

    Akiba, Yasuhiro; Imamura, Kenji; Sumita, Eiichiro; Nakaiwa, Hiromi; Yamamoto, Seiichi; Okuno, Hiroshi G.

    This paper addresses the challenging problem of automating the human's intelligent ability to evaluate output from machine translation (MT) systems, which are subsystems of Speech-to-Speech MT (SSMT) systems. Conventional automatic MT evaluation methods include BLEU, which MT researchers have frequently used. BLEU is unsuitable for SSMT evaluation for two reasons. First, BLEU assesses errors lightly at the beginning or ending of translations and heavily in the middle, although the assessments should be independent from the positions. Second, BLEU lacks tolerance in accepting colloquial sentences with small errors, although such errors do not prevent us from continuing conversation. In this paper, the authors report a new evaluation method called RED that automatically grades each MT output by using a decision tree (DT). The DT is learned from training examples that are encoded by using multiple edit distances and their grades. The multiple edit distances are normal edit dista nce (ED) defined by insertion, deletion, and replacement, as well as extensions of ED. The use of multiple edit distances allows more tolerance than either ED or BLEU. Each evaluated MT output is assigned a grade by using the DT. RED and BLEU were compared for the task of evaluating SSMT systems, which have various performances, on a spoken language corpus, ATR's Basic Travel Expression Corpus (BTEC). Experimental results showed that RED significantly outperformed BLEU.

  5. Influenza vaccination of Michigan children by provider type, 2010-2011.

    Science.gov (United States)

    Clayton, Joshua L; Potter, Rachel C; Wells, Eden V; Carlton, Cristi A; Boulton, Matthew L

    2014-07-01

    Influenza vaccination for all children aged 6 months to 18 years has been recommended since 2008 to prevent flu-related morbidity and mortality. However, 2010-2011 influenza vaccine coverage estimates show under-vaccination in children of all ages. We examined predictors of influenza vaccination in Michigan during the 2010-2011 influenza season. To determine whether immunization provider type was associated with a child's influenza vaccination in Michigan and assess whether county-level factors were confounders of the association. Influenza vaccinations reported to the Michigan Care Improvement Registry from the 2010-2011 influenza season were analyzed in 2012 to estimate ORs for the association between immunization provider type and influenza vaccination. Among 2,373,826 Michigan children aged 6 months through 17 years, 17% were vaccinated against influenza and lower vaccination rates were observed for public compared to private providers (13% vs 18%). In the unadjusted model, public providers had lower odds of vaccinating children compared to private providers (OR=0.60, 95% CI=0.60, 0.61). County-level factors, including percentage of families living below the poverty line, median household income, and percentage black race, were not shown to confound the association. In the adjusted models, public providers had lower odds of vaccinating children compared to private providers (OR=0.87, 95% CI=0.86, 0.88). Although a child's likelihood of influenza vaccination in Michigan varies by provider type, more effective strategies to improve influenza vaccination rates for all Michigan children are needed. Copyright © 2014 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

  6. From Lean Times to Enrollment Declines: The Governor's Commission on the Future of Higher Education in Michigan. ASHE Annual Meeting Paper.

    Science.gov (United States)

    Widmayer, Patricia

    Conditions in higher education in Michigan and the role of the Governor's Commission on the Future of Higher Education in Michigan are highlighted. The average college tuition rate in Michigan is the highest in the nation, and a critical maintenance and equipment problem exists. The Commission is composed of knowledgeable persons without vested…

  7. Introduction and spread of the threespine stickleback (Gasterosteus aculeatus) in Lakes Huron and Michigan

    Science.gov (United States)

    Stedman, Ralph M.; Bowen, Charles A.

    1985-01-01

    The threespine stickleback (Gasterosteus aculeatus) was not known to occur in the Great Lakes above Niagara Falls until 1980, when it was collected in South Bay, Manitoulin Island, in the Lake Huron basin. By 1984 this species had been found in tributaries of Lakes Huron and Michigan, and in the open waters of both lakes. All specimens identified were the completely plated morph that is most prevalent in fresh water along the east coast of North America. The status of this species in Lakes Huron and Michigan appears to be “Possibly Established.” If threespine stickleback increase in abundance they may eventually provide additional forage for large salmonids.

  8. Results of the independent radiological verification survey at 4400 Piehl Road, Ottawa Lake, Michigan (BTO002)

    Energy Technology Data Exchange (ETDEWEB)

    Murray, M.E.; Brown, K.S.

    1996-04-01

    At the request of the US Department of Energy (DOE), a team from Oak Ridge National Laboratory (ORNL) conducted an independent radiological verification survey at Ottawa Lake, Michigan. The survey was performed in November and December of 1994. The purpose of the survey was to verify that the site was remediated to levels below the DOE guidelines for FUSRAP sites. Results of the independent radiological verification survey at Ottawa Lake, Michigan confirm that the residual uranium contamination at the site is below DOE FUSRAP guidelines for unrestricted use.

  9. Determination of arsenic in some Lake Michigan fish using neutron activation analysis

    International Nuclear Information System (INIS)

    Nicholson, L.W.; Rengan, K.

    1979-01-01

    The level of arsenic in six different species of fish collected from Lake Michigan near Saugatuck, Michigan has been measured using radiochemical neutron activation analysis. The arsenic concentration was found to vary from 0.05 μg/g (wet weight) for yellow perch fillet to 1.4 μg/g (wet weight) for eviscerated bloater chubs. A significant correlation was observed between arsenic concentrations and number of years in the lake for lake trout; correlations were also observed between arsenic concentrations and length of lake trout and smelt. No such correlations were found for alewife or yellow perch. (author)

  10. Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas.

    Directory of Open Access Journals (Sweden)

    A G de Lucas

    Full Text Available A critical challenge in the management of Glioblastoma Multiforme (GBM tumors is the accurate diagnosis and assessment of tumor progression in a noninvasive manner. We have identified Membrane-type 1 matrix metalloproteinase (MT1-MMP as an attractive biomarker for GBM imaging since this protein is actively involved in tumor growth and progression, correlates with tumor grade and is closely associated with poor prognosis in GBM patients. Here, we report the development of an immunoPET tracer for effective detection of MT1-MMP in GBM models.An anti-human MT1-MMP monoclonal antibody (mAb, LEM2/15, was conjugated to p-isothiocyanatobenzyl-desferrioxamine (DFO-NCS for 89Zr labeling. Biodistribution and PET imaging studies were performed in xenograft mice bearing human GBM cells (U251 expressing MT1-MMP and non-expressing breast carcinoma cells (MCF-7 as negative control. Two orthotopic brain GBM models, patient-derived neurospheres (TS543 and U251 cells, with different degrees of blood-brain barrier (BBB disruption were also used for PET imaging experiments.89Zr labeling of DFO-LEM2/15 was achieved with high yield (>90% and specific activity (78.5 MBq/mg. Biodistribution experiments indicated that 89Zr-DFO-LEM2/15 showed excellent potential as a radiotracer for detection of MT1-MMP positive GBM tumors. PET imaging also indicated a specific and prominent 89Zr-DFO-LEM2/15 uptake in MT1-MMP+ U251 GBM tumors compared to MT1-MMP- MCF-7 breast tumors. Results obtained in orthotopic brain GBM models revealed a high dependence of a disrupted BBB for tracer penetrance into tumors. 89Zr-DFO-LEM2/15 showed much higher accumulation in TS543 tumors with a highly disrupted BBB than in U251 orthotopic model in which the BBB permeability was only partially increased. Histological analysis confirmed the specificity of the immunoconjugate in all GBM models.A new anti MT1-MMP-mAb tracer, 89Zr-DFO-LEM2/15, was synthesized efficiently. In vivo validation showed high

  11. Habitat assessment of non-wadeable rivers in Michigan.

    Science.gov (United States)

    Wilhelm, Jennifer G O; Allan, J David; Wessell, Kelly J; Merritt, Richard W; Cummins, Kenneth W

    2005-10-01

    Habitat evaluation of wadeable streams based on accepted protocols provides a rapid and widely used adjunct to biological assessment. However, little effort has been devoted to habitat evaluation in non-wadeable rivers, where it is likely that protocols will differ and field logistics will be more challenging. We developed and tested a non-wadeable habitat index (NWHI) for rivers of Michigan, where non-wadeable rivers were defined as those of order >or=5, drainage area >or=1600 km2, mainstem lengths >or=100 km, and mean annual discharge >or=15 m3/s. This identified 22 candidate rivers that ranged in length from 103 to 825 km and in drainage area from 1620 to 16,860 km2. We measured 171 individual habitat variables over 2-km reaches at 35 locations on 14 rivers during 2000-2002, where mean wetted width was found to range from 32 to 185 m and mean thalweg depth from 0.8 to 8.3 m. We used correlation and principal components analysis to reduce the number of variables, and examined the spatial pattern of retained variables to exclude any that appeared to reflect spatial location rather than reach condition, resulting in 12 variables to be considered in the habitat index. The proposed NWHI included seven variables: riparian width, large woody debris, aquatic vegetation, bottom deposition, bank stability, thalweg substrate, and off-channel habitat. These variables were included because of their statistical association with independently derived measures of human disturbance in the riparian zone and the catchment, and because they are considered important in other habitat protocols or to the ecology of large rivers. Five variables were excluded because they were primarily related to river size rather than anthropogenic disturbance. This index correlated strongly with indices of disturbance based on the riparian (adjusted R2 = 0.62) and the catchment (adjusted R2 = 0.50), and distinguished the 35 river reaches into the categories of poor (2), fair (19), good (13), and

  12. Ground-water contamination at Wurtsmith Air Force Base, Michigan

    Science.gov (United States)

    Stark, J.R.; Cummings, T.R.; Twenter, F.R.

    1983-01-01

    A sand and gravel aquifer of glacial origin underlies Wurtsmith Air Force Base in northeastern lower Michigan. The aquifer overlies a thick clay layer at an average depth of 65 feet. The water table is about 10 feet below land surface in the western part of the Base and about 25 feet below land surface in the eastern part. A ground-water divide cuts diagonally across the Base from northwest to southeast. South of the divide, ground water flows to the Au Sable River; north of the divide, it flows to Van Etten Creek and Van Etten Lake. Mathematical models were used to aid in calculating rates of groundwater flow. Rates range from about 0.8 feet per day in the eastern part of the Base to about 0.3 feet per day in the western part. Models also were used as an aid in making decisions regarding purging of contaminated water from the aquifer. In 1977, trichloroethylene was detected in the Air Force Base water-supply system. It had leaked from a buried storage tank near Building 43 in the southeastern part of the Base and moved northeastward under the influence of the natural ground-water gradient and the pumping of Base water-supply wells. In the most highly contaminated part of the plume, concentrations are greater than 1,000 micrograms per liter. Current purge pumping is removing some of the trichloroethylene, and seems to have arrested its eastward movement. Pumping of additional purge wells could increase the rate of removal. Trichloroethylene has also been detected in ground water in the vicinity of the Base alert apron, where a plume from an unknown source extends northeastward off Base. A smaller, less well-defined area of contamination also occurs just north of the larger plume. Trichloroethylene, identified near the waste-treatment plant, seepage lagoons, and the northern landfill area, is related to activities and operations in these areas. Dichloroethylene and trichloroethylene occur in significant quantities westward of Building 43, upgradient from the major

  13. Michigan Oncology Medical Home Demonstration Project: First-Year Results.

    Science.gov (United States)

    Kuntz, Gordon; Tozer, Jane; Snegosky, Jeff; Fox, John; Neumann, Kurt

    2014-03-01

    The Michigan Oncology Medical Home Demonstration Project (MOMHDP) is an innovative multipractice oncology medical home model, supported by payment reform. Sponsored by Priority Health, Physician Resource Management, and ION Solutions, MOMHDP includes four oncology practices and 29 physicians. Oncology practices used existing technologies, with MOMHDP providing evidence-based treatment guideline selection and compliance tracking, automated physician order entry, a patient portal, symptom management/standardized nurse triage, and advance care planning. To support changes in care and administrative models and to focus on quality, MOMHDP modifies provider payments. The program replaces the average sales price payment methodology with a drug acquisition reimbursement plus a care management fee, calculated to increase total drug reimbursement. Additionally, it reimburses for chemotherapy and treatment planning and advance care planning consultation. There is also a shared savings opportunity. MOMHDP will be enhanced in its second year to include a survivorship program, patient distress screening, imaging guidelines, and standardized patient satisfaction surveys. Priority Health patients receiving chemotherapy for a cancer diagnosis were recruited to the program. Results for this group were compared with a control group of patients from a prior period. In addition to the financial results, the project also accomplished the following: (1) adherence to practice-selected guidelines, (2) institution of advance care planning, (3) effective and standardized symptom management; and (4) payment reform. We have identified a number of critical success factors: strong payer/provider collaboration built on trust through transparent use and cost data; timing of clinical standardization must come from the practices, so they can effectively absorb new approaches; having comprehensive, written program documentation and consistently applied training facilitate practice understanding

  14. Full-wave Ambient Noise Tomography of Mt Rainier volcano, USA

    Science.gov (United States)

    Flinders, Ashton; Shen, Yang

    2015-04-01

    Mount Rainier towers over the landscape of western Washington (USA), ranking with Fuji-yama in Japan, Mt Pinatubo in the Philippines, and Mt Vesuvius in Italy, as one of the great stratovolcanoes of the world. Notwithstanding its picturesque stature, Mt Rainier is potentially the most devastating stratovolcano in North America, with more than 3.5 million people living beneath is shadow in the Seattle-Tacoma area. The primary hazard posed by the volcano is in the form of highly destructive debris flows (lahars). These lahars form when water and/or melted ice erode away and entrain preexisting volcanic sediment. At Mt Rainier these flows are often initiated by sector collapse of the volcano's hydrothermally rotten flanks and compounded by Mt Rainier's extensive snow and glacial ice coverage. It is therefore imperative to ascertain the extent of the volcano's summit hydrothermal alteration, and determine areas prone to collapse. Despite being one of the sixteen volcanoes globally designated by the International Association of Volcanology and Chemistry of the Earth's Interior as warranting detailed and focused study, Mt Rainier remains enigmatic both in terms of the shallow internal structure and the degree of summit hydrothermal alteration. We image this shallow internal structure and areas of possible summit alteration using ambient noise tomography. Our full waveform forward modeling includes high-resolution topography allowing us to accuratly account for the effects of topography on the propagation of short-period Rayleigh waves. Empirical Green's functions were extracted from 80 stations within 200 km of Mt Rainier, and compared with synthetic greens functions over multiple frequency bands from 2-28 seconds.

  15. Efficient inhibition of heavy metal release from mine tailings against acid rain exposure by triethylenetetramine intercalated montmorillonite (TETA-Mt).

    Science.gov (United States)

    Gong, Beini; Wu, Pingxiao; Huang, Zhujian; Li, Yuanyuan; Yang, Shanshan; Dang, Zhi; Ruan, Bo; Kang, Chunxi

    2016-11-15

    The potential application of triethylenetetramine intercalated montmorillonite (TETA-Mt) in mine tailings treatment and AMD (acid mine drainage) remediation was investigated with batch experiments. The structural and morphological characteristics of TETA-Mt were analyzed with XRD, FTIR, DTG-TG and SEM. The inhibition efficiencies of TETA-Mt against heavy metal release from mine tailings when exposed to acid rain leaching was examined and compared with that of triethylenetetramine (TETA) and Mt. Results showed that the overall inhibition by TETA-Mt surpassed that by TETA or Mt for various heavy metal ions over an acid rain pH range of 3-5.6 and a temperature range of 25-40°C. When mine tailings were exposed to acid rain of pH 4.8 (the average rain pH of the mining site where the mine tailings were from), TETA-Mt achieved an inhibition efficiency of over 90% for Cu(2+), Zn(2+), Cd(2+) and Mn(2+) release, and 70% for Pb(2+) at 25°C. It was shown that TETA-Mt has a strong buffering capacity. Moreover, TETA-Mt was able to adsorb heavy metal ions and the adsorption process was fast, suggesting that coordination was mainly responsible. These results showed the potential of TETA-Mt in AMD mitigation, especially in acid rain affected mining area. Copyright © 2016 Elsevier B.V. All rights reserved.

  16. Immobilization of metallothionein to carbon paste electrode surface via anti-MT antibodies and its use for biosensing of silver.

    Science.gov (United States)

    Trnkova, Libuse; Krizkova, Sona; Adam, Vojtech; Hubalek, Jaromir; Kizek, Rene

    2011-01-15

    In this paper, heavy metal biosensor based on immobilization of metallothionein (MT) to the surface of carbon paste electrode (CPE) via anti-MT-antibodies is reported. First, the evaluation of MT electroactivity was done. The attention was focused on the capturing of MT to the CPE surface. Antibodies incorporated and mixed into carbon paste were stable; even after two weeks the observed changes in signal height were lower than 5%. Further, the interaction of MT with polyclonal chicken antibodies incorporated in carbon paste electrode was determined by square-wave voltammetry. In the voltammogram, two signals--labelled as cys(MT) and W(a)--were observed. The cys(MT) corresponded to -SH moieties of MT and W(a) corresponded to tryptophan residues of chicken antibodies. Time of interaction (300 s) and MT concentration (125 μg/ml) were optimized to suggest a silver(I) ions biosensor. Biosensor (CPE modified with anti-MT antibody) prepared under the optimized conditions was then used for silver(I) ions detection. The detection limit (3 S/N) for silver(I) ions was estimated as 0.5 nM. The proposed biosensor was tested by detection spiking of silver(I) ions in various water samples (from very pure distilled water to rainwater). Recoveries varied from 74 to 104%. Copyright © 2010 Elsevier B.V. All rights reserved.

  17. IFPE/MT4-MT6A-LOCA, Large-break LOCA in-reactor fuel bundle materials tests at NRU

    International Nuclear Information System (INIS)

    Cunningham, Mitchel E.; Turnbull, J.A.

    2003-01-01

    Description - Objectives - Results: The U.S. Nuclear Regulatory Commission (NRC) conducted a series of thermal-hydraulic and cladding mechanical deformation tests in the National Research Universal (NRU) reactor at the Chalk River National Laboratory in Canada. The objective of these tests was to perform simulated loss-of-coolant-accident (LOCA) experiments using full-length light-water reactor fuel rods to study mechanical deformation, flow blockage, and coolability. Three phases of a LOCA (i.e., heat-up, reflood, and quench) were performed in situ using nuclear fissioning to simulate the low-level decay power during a LOCA after shutdown. All tests used PWR-type, non-irradiated fuel rods. Provided here is information on two materials tests, MT-6A and MT-4, which PNNL considers the better characterized for the purposes of setting up computer cases. The NRU reactor is a heterogeneous, thermal, tank-type research reactor. It has a power level of 135 MWth and is heavy-water moderated and cooled. The coolant has an inlet temperature of 310 K at a pressure of 0.65 MPa. The MT tests were conducted in a specially designed test train to supply the specified coolant conditions of flowing steam, stagnant steam, and then reflood. Typical instrumentation for the MT tests included fuel centerline thermocouples, cladding inner surface thermocouples, cladding outer surface thermocouples, rod internal gas pressure transducers or pressure switches, coolant channel steam probes, and self-powered neutron detectors. This instrumentation allowed for determining rupture times and cladding temperature. The test rods for the LOCA cases in the NRU reactor were irradiated in flowing steam prior to the transient, stagnant steam during the transient and prior to reflood, and then reflood conditions to complete the transient. Both cladding inner surface and outer surface temperatures were measured, in addition to coolant temperatures. However, only cladding inner surface temperatures were

  18. The Coping Strategies of Nontraditional Female Students in Southwest Michigan and Northern Indiana

    Science.gov (United States)

    Davis, Desiree

    2017-01-01

    Problem: The purpose of this research study was to examine the coping strategies of nontraditional female students in a private university in Southwest Michigan, and a public university in Northern Indiana. According to Carney-Compton & Tan (2002), nontraditional female students characterize the leading emergent set of students beginning…

  19. Teaching Practices in Principles of Economics Courses at Michigan Community Colleges.

    Science.gov (United States)

    Utech, Claudia J.; Mosti, Patricia A.

    1995-01-01

    Presents findings from a study of teaching practices in Principles of Economics courses at Michigan's 29 community colleges. Describes course prerequisites; textbooks used; lecture supplements; and the use of experiential learning tools, such as computers and field trips. Presents three recommendations for improving student preparation in…

  20. Impact of School Finance Reform on Resource Equalization and Academic Performance: Evidence from Michigan

    Science.gov (United States)

    Roy, Joydeep

    2011-01-01

    Michigan radically altered its school finance system in 1994. The new plan, called Proposal A, significantly increased state aid to the lowest-spending school districts and limited future increases in spending in the highest-spending ones, abolishing local discretion over school spending. I investigate the impact of Proposal A on the distribution…

  1. Three-year progression of emerald ash borer-induced decline and mortality in southeastern Michigan

    Science.gov (United States)

    Kamal J.K. Gandhi; Annemarie Smith; Robert P. Long; Robin A.J. Taylor; Daniel A. Herms

    2008-01-01

    We monitored the progression of ash (Fraxinus spp.) decline and mortality due to emerald ash borer (EAB), Agrilus planipennis, in 38 forest stands in the upper Huron River watershed region of southeastern Michigan from 2004-2007. Black ash (F. nigra), green ash (F. pennsylvanica), and white ash...

  2. Eastern Michigan University's Automated Storage and Retrieval System: 10 Years Later

    Science.gov (United States)

    Bullard, Rita; Wrosch, Jackie

    2009-01-01

    Automated storage/retrieval systems (ASRSs) are playing an integral part in today's library operations and collections management. Eastern Michigan University installed an ASRS as part of the new Halle Library, which opened in May 1998, to provide "storage" for up to 800,000 items. Over the past 10 years our policies and procedures have…

  3. 76 FR 73670 - Notice of Inventory Completion: University of Michigan Museum of Anthropology, Ann Arbor, MI

    Science.gov (United States)

    2011-11-29

    ...: University of Michigan Museum of Anthropology, Ann Arbor, MI AGENCY: National Park Service, Interior. ACTION... Museum of Anthropology NAGPRA collections staff in consultation with representatives of the Bay Mills... Anthropology purchased the human remains from Reverend L. P. Rowland in November of 1924 as part of a larger...

  4. Can Universal, Place-Based Scholarships Reduce Inequality? Lessons from Kalamazoo, Michigan

    Science.gov (United States)

    Miller-Adams, Michelle

    2010-01-01

    The Kalamazoo Promise, announced in 2005, is an innovative college-scholarship program available to every graduate of the Kalamazoo (Michigan) Public Schools. Programs such as the Kalamazoo Promise, which is being emulated in cities across the United States, open new avenues for the acquisition of human capital regardless of income level or…

  5. 77 FR 65478 - Approval and Promulgation of Air Quality Implementation Plans; Illinois; Indiana; Michigan...

    Science.gov (United States)

    2012-10-29

    ... designed to ensure that the structural components of each State's air quality management program are... Department of Environmental Management (IDEM); Michigan Department of Environmental Quality (MDEQ); Minnesota... components of each State's air quality management program are adequate to meet the State's responsibilities...

  6. 76 FR 41075 - Approval and Promulgation of Air Quality Implementation Plans; Illinois; Indiana; Michigan...

    Science.gov (United States)

    2011-07-13

    ... requirements are designed to ensure that the structural components of each state's air quality management... Management (IDEM); Michigan Department of Environmental Quality (MDEQ); Minnesota Pollution Control Agency... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 [EPA-R05-OAR-2007-1179; FRL-9436-7] Approval and...

  7. 76 FR 63190 - Michigan State Plan; Change in Level of Federal Enforcement: Indian Tribes

    Science.gov (United States)

    2011-10-12

    ... issues covered by the state's OSHA-approved occupational safety and health plan. Federal OSHA retained... DEPARTMENT OF LABOR Occupational Safety and Health Administration 29 CFR Part 1952 Michigan State Plan; Change in Level of Federal Enforcement: Indian Tribes AGENCY: Occupational Safety and Health...

  8. Hardwood Face Veneer and Plywood Mill Closures in Michigan and Wisconsin Since 1950

    Science.gov (United States)

    Lewis T. Hendricks

    1966-01-01

    In recent years there has been a great deal of concern about the closure of numberous hardwood face veneer and plywood mills in Michigan and Wisconsin. As part of an overall study of that industry in the northern Lake States region, the basic reasons leading to the closure of these mills were investigated. In the past 15 years, there have been eight known mill...

  9. Teaching, Research, and Service: The Satisfiers of Education Faculty at Western Michigan University.

    Science.gov (United States)

    Serafin, Ana Gil

    This report investigated a random sample of 54 (divided equally between male and female) full-time regular education faculty actively engaged in classroom activities at Western Michigan University in Venezuelan postsecondary education to learn: (1) their satisfaction levels with their role functions of teaching, research, and service; and (2) if…

  10. Diagnosis and management of new and re-emerging diseases of highbush blueberries in Michigan

    Science.gov (United States)

    Blueberries are an important commodity in Michigan and disease management is crucial for production of high-quality fruit. Over the past 6 years, a number of new and re-emerging diseases have been diagnosed in the state. In 2009, Blueberry scorch virus (BlScV) and Blueberry shock virus (BlShV) were ...

  11. Effects on the Mount St. Helens volcanic cloud on turbidity at Ann Arbor, Michigan

    International Nuclear Information System (INIS)

    Ryznar, E.; Weber, M.R.; Hallaron, T.S.

    1981-01-01

    Measurements of turbidity were made at the University of Michigan irradiance and metorlogical measurement facility just prior to, during and after the passage of the volcanic cloud from the 18 May 1980 eruption of Mount St. Helens. They were made with a Volz sunphotometer at wavelengths of 500 and 880 nm

  12. Current Condition of Michigan Curriculum Materials Centers and Collections in Academic Institutions

    Science.gov (United States)

    Kohrman, Rita

    2015-01-01

    A 2005 sabbatical study revealed 24 unique curriculum materials centers or collections (CMCs) in Michigan colleges or universities. The focus of the study was to investigate the number, characteristics, and quality of these centers and collections supporting education faculty and students. A follow up 2014 study asked how or if the Michigan…

  13. Beyond Rural Idylls: Imperfect Lesbian Utopias at Michigan Womyn's Music Festival

    Science.gov (United States)

    Browne, Kath

    2011-01-01

    Whilst rural idylls have dominated some discussions of rural social difference, little attention has been paid to rural utopias. Imagined, material and discursive experiences of utopian rural ideals are critically examined in this paper. It takes as its focus the Michigan Womyn's Music Festival--an annual US womyn-only festival--in order to…

  14. Michigan Wetlands: Yours To Protect. A Citizen's Guide to Local Involvement in Wetland Protection. Second Edition.

    Science.gov (United States)

    Cwikiel, Wilfred

    This guidebook is designed to assist concerned Michigan citizens, local governments, conservation organizations, landowners, and others in their efforts to initiate wetlands protection activities. Chapter 1 focuses on wetland functions, values, losses, and the urgent need to protect wetland resources. Chapter 2 discusses wetland identification and…

  15. A short-term look at potential changes in Lake Michigan slimy sculpin diets

    Science.gov (United States)

    French, John R. P.; Stickel, Richard G.; Stockdale, Beth A.; Black, M. Glen

    2010-01-01

    Diporeia hoyi and Mysis relicta are the most important prey items of slimy sculpins (Cottus cognatus) in the Great Lakes. Slimy sculpins were collected from dreissenid-infested bottoms off seven Lake Michigan ports at depths of 27–73 m in fall 2003 to study their lake-wide diets. Relatively large dreissenid biomass occurred at depths of 37- and 46-m. Quagga mussels (Dreissena bugnesis) composed at least 50% of dreissenid biomass at Manistique, Saugatuck, and Sturgeon Bay. Mysis accounted for 82% of the sculpin diet by dry weight at eastern Lake Michigan while Diporeia composed 54–69% of the diet at western Lake Michigan and dominated the diets of slimy sculpins at all sites deeper than 46 m. In northern Lake Michigan, this diet study in new sites showed that slimy sculpin consumed more prey with low energy contents, especially chironomids, than Mysis and Diporeia in shallow sites (depth diet studies on sedentary benthic fishes to be conducted along perimeters of the Great Lakes to observe changes in their diets that may be impacted by changing benthic macroinvertebrate communities.

  16. Estimating the Efficiency of Michigan's Rural and Urban Public School Districts

    Science.gov (United States)

    Maranowski, Rita

    2012-01-01

    This study examined student achievement in Michigan public school districts to determine if rural school districts are demonstrating greater financial efficiency by producing higher levels of student achievement than school districts in other geographic locations with similar socioeconomics. Three models were developed using multiple regression…

  17. 78 FR 34124 - Notice of Inventory Completion: Michigan Department of Transportation, Van Wagoner Building...

    Science.gov (United States)

    2013-06-06

    ...; Bad River Band of the Lake Superior Tribe of Chippewa Indians of the Bad River Reservation, Wisconsin... removed is the aboriginal land of the Bad River Band of the Lake Superior Tribe of Chippewa Indians of the Bad River Reservation, Wisconsin; Bay Mills Indian Community, Michigan; Bois Forte Band (Nett Lake) of...

  18. Screening for Drug Abuse Among College Students: Modification of the Michigan Alcoholism Screening Test

    Science.gov (United States)

    Cannell, M. Barry; Favazza, Armando R.

    1978-01-01

    Modified version of the Michigan Alcoholism Screening Test was anonymously given to 245 college students on two Midwestern university campuses. Cutoff score for suspected drug abuse was set at five points. The percent of students scoring five or more points was 25 and 22 from campuses A and B respectively. (Author)

  19. INVESTIGATION OF VERTICAL DISTRIUBTION AND MORPHO- LOGY OF INDIGENOUS ORGANIC MATTER AT SLEEPING BEAR SITE, MICHIGAN

    Science.gov (United States)

    This study evaluates the nature and origin of particulate organic carbon and organic coatings on aquifer sands upgradient from a fuel spill site near the Sleeping Bear Dunes National Lakeshore in Michigan. The distribution of carbon was found to be highly complex due to the occur...

  20. Field responses of Prunus serotina and Asclepias syriaca to ozone around southern Lake Michigan

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, J.P. [U.S. Geological Survey and Institute for Environmental Studies, University of Wisconsin, Madison, WI 53706 (United States)]. E-mail: jpbennet@wisc.edu; Jepsen, E.A. [Bureau of Air Management, Wisconsin Department of Natural Resources, Madison, WI 53707 (United States); Roth, J.A. [Bureau of Air Management, Wisconsin Department of Natural Resources, Madison, WI 53707 (United States)

    2006-07-15

    Higher ozone concentrations east of southern Lake Michigan compared to west of the lake were used to test hypotheses about injury and growth effects on two plant species. We measured approximately 1000 black cherry trees and over 3000 milkweed stems from 1999 to 2001 for this purpose. Black cherry branch elongation and milkweed growth and pod formation were significantly higher west of Lake Michigan while ozone injury was greater east of Lake Michigan. Using classification and regression tree (CART) analyses we determined that departures from normal precipitation, soil nitrogen and ozone exposure/peak hourly concentrations were the most important variables affecting cherry branch elongation, and milkweed stem height and pod formation. The effects of ozone were not consistently comparable with the effects of soil nutrients, weather, insect or disease injury, and depended on species. Ozone SUM06 exposures greater than 13 ppm-h decreased cherry branch elongation 18%; peak 1-h exposures greater than 93 ppb reduced milkweed stem height 13%; and peak 1-h concentrations greater than 98 ppb reduced pod formation 11% in milkweed. - Decreased cherry branch elongation, milkweed stem height and pod production, and foliar injury on both species occurred at sites around southern Lake Michigan at ozone exposures of 13 SUM06 ppm-h and 93-98 ppb peak hourly.

  1. Field responses of Prunus serotina and Asclepias syriaca to ozone around southern Lake Michigan

    International Nuclear Information System (INIS)

    Bennett, J.P.; Jepsen, E.A.; Roth, J.A.

    2006-01-01

    Higher ozone concentrations east of southern Lake Michigan compared to west of the lake were used to test hypotheses about injury and growth effects on two plant species. We measured approximately 1000 black cherry trees and over 3000 milkweed stems from 1999 to 2001 for this purpose. Black cherry branch elongation and milkweed growth and pod formation were significantly higher west of Lake Michigan while ozone injury was greater east of Lake Michigan. Using classification and regression tree (CART) analyses we determined that departures from normal precipitation, soil nitrogen and ozone exposure/peak hourly concentrations were the most important variables affecting cherry branch elongation, and milkweed stem height and pod formation. The effects of ozone were not consistently comparable with the effects of soil nutrients, weather, insect or disease injury, and depended on species. Ozone SUM06 exposures greater than 13 ppm-h decreased cherry branch elongation 18%; peak 1-h exposures greater than 93 ppb reduced milkweed stem height 13%; and peak 1-h concentrations greater than 98 ppb reduced pod formation 11% in milkweed. - Decreased cherry branch elongation, milkweed stem height and pod production, and foliar injury on both species occurred at sites around southern Lake Michigan at ozone exposures of 13 SUM06 ppm-h and 93-98 ppb peak hourly

  2. Characterization of Beauveria bassiana (Ascomycota: Hypocreales) isolates associated with Agrilus planipennis (Coleoptera: Buprestidae) populations in Michigan

    Science.gov (United States)

    Louela A. Castrillo; Leah S. Bauer; Houping Liu; Michael H. Griggs; John D. Vandenberg

    2010-01-01

    Earlier research in Michigan on fungal entomopathogens of the emerald ash borer (EAB), a major invasive pest of ash trees, resulted in the isolation of Beauveria bassiana from late-instar larvae and pre-pupae. In the present study, some of these isolates were characterized and compared to ash bark- and soil-derived isolates to determine their...

  3. 77 FR 55139 - Safety Zone; Chicago Red Bull Flugtag, Lake Michigan, Chicago, IL

    Science.gov (United States)

    2012-09-07

    ..., Protection of Children from Environmental Health Risks and Safety Risks. This rule is not an economically significant rule and does not create an environmental risk to health or risk to safety that may..., Chicago, IL. The Captain of the Port, Sector Lake Michigan, has determined that the Red Bull Flugtag event...

  4. 76 FR 79536 - Security Zones; Captain of the Port Lake Michigan; Technical Amendment

    Science.gov (United States)

    2011-12-22

    ... Environmental Health Risks and Safety Risks. This rule is not an economically significant rule and does not create an environmental risk to health or risk to safety that may disproportionately affect children...-AA87 Security Zones; Captain of the Port Lake Michigan; Technical Amendment AGENCY: Coast Guard, DHS...

  5. Guided Educational Tourism as Informal Physical Geography Education on St. Helena Island, Michigan

    Science.gov (United States)

    Lane, Joseph M.; Stoltman, Joseph P.

    2017-01-01

    Guided educational tours are a major activity within informal education. This article examines the potential for tour guides of a largely historical tour of St. Helena Island, Michigan, to include physical geography within the tour. Using field data and interview methods, the researchers identified the physical features of the island that could be…

  6. 78 FR 65364 - Notice of Inventory Completion: University of Michigan, Ann Arbor, MI

    Science.gov (United States)

    2013-10-31

    ... this section are referred to as ``The Tribes.'' History and Description of the Remains In 1958, human... County, MI. A landowner unearthed human remains while digging a gas line trench on his property. He... Service, Interior. ACTION: Notice. SUMMARY: The University of Michigan has completed an inventory of human...

  7. IMPORTANCE OF TEMPERATURE IN MODELLING PCB BIOACCUMULATION IN THE LAKE MICHIGAN FOOD WEB

    Science.gov (United States)

    In most food web models, the exposure temperature of a food web is typically defined using a single spatial compartment. This essentially assumes that the predator and prey are exposed to the same temperature. However, in a large water body such as Lake Michigan, due to the spati...

  8. Renewable energy potential on brownfield sites: A case study of Michigan

    International Nuclear Information System (INIS)

    Adelaja, Soji; Shaw, Judy; Beyea, Wayne; Charles McKeown, J.D.

    2010-01-01

    Federal priorities are increasingly favoring the replacement of conventional sources of energy with renewable energy. With the potential for a federal Renewable Electricity Standard (RES) legislation, many states are seeking to intensify their renewable energy generation. The demand for wind, solar, geothermal and bio-fuels-based energy is likely to be rapidly expressed on the landscape. However, local zoning and NIMBYism constraints slow down the placement of renewable energy projects. One area where land constraints may be lower is brownfields; whose development is currently constrained by diminished housing, commercial, and industrial property demand. Brownfield sites have the potential for rapid renewable energy deployment if state and national interests in this area materialize. This study investigates the application of renewable energy production on brownfield sites using Michigan as a case study. Wind and solar resource maps of Michigan were overlaid with the brownfield locations based on estimates of brownfield land capacity. The total estimated energy potential available on Michigan's brownfield sites is 4320 megawatts (MW) of plate capacity for wind and 1535for solar, equating to 43% of Michigan's residential electricity consumption (using 30% capacity factor). Estimated economic impacts include over $15 billion in investments and 17,500 in construction and long-term jobs.

  9. 78 FR 59966 - Notice of Inventory Completion: Michigan State Police, Jackson Post, Jackson, MI

    Science.gov (United States)

    2013-09-30

    ... Repatriation Act (NAGPRA), 25 U.S.C. 3003, of the completion of an inventory of human remains under the control....R50000] Notice of Inventory Completion: Michigan State Police, Jackson Post, Jackson, MI AGENCY: National... completed an inventory of human remains, following the initiation of consultation with the appropriate...

  10. Fusarium spp. causing dry rot of seed potato tubers in Michigan and their sensitivity to fungicides

    Science.gov (United States)

    Fusarium dry rot of potato (Solanum tuberosum L.) is a postharvest disease that can be caused by several Fusarium spp. A survey was conducted to establish the composition of Fusarium species causing dry rot of seed tubers in Michigan. A total of 370 dry rot symptomatic tubers were collected in 2009 ...

  11. Antimicrobial Drug-Resistant Shiga Toxin-Producing Escherichia coli Infections, Michigan, USA.

    Science.gov (United States)

    Mukherjee, Sanjana; Mosci, Rebekah E; Anderson, Chase M; Snyder, Brian A; Collins, James; Rudrik, James T; Manning, Shannon D

    2017-09-01

    High frequencies of antimicrobial drug resistance were observed in O157 and non-O157 Shiga toxin-producing E. coli strains recovered from patients in Michigan during 2010-2014. Resistance was more common in non-O157 strains and independently associated with hospitalization, indicating that resistance could contribute to more severe disease outcomes.

  12. Change Agent Strategies: A Study of the Michigan-Ohio Regional Educational Laboratory.

    Science.gov (United States)

    Miller, Peggy Lynne

    This dissertation reports on a study of the planning and development activities of the Michigan-Ohio Regional Educational Laboratory (MOREL). The study attempted to assess (1) whether MOREL has accepted a change agent role, and (2) whether it has taken action that indicates recognition of what is known through the literature and research about…

  13. The age, growth, and bathymetric distribution of Reighard's chub, Leucichthys reighardi koelz, in Lake Michigan

    Science.gov (United States)

    1943-01-01

    Reighard's chub has come to be one of the most important species of the group since the serious decline in abundance of the larger representatives of the genus Leucichthys in Lake Michigan. An understanding of the biology of as many species of chubs as possible is essential if further depletion and the collapse of the fishery are to be prevented.

  14. Urban and community forests of the North Central East region: Illinois, Indiana, Michigan, Ohio, Wisconsin

    Science.gov (United States)

    David J. Nowak; Eric J. Greenfield

    2010-01-01

    This report details how land cover and urbanization vary within the states of Illinois, Indiana, Michigan, Ohio, and Wisconsin by community (incorporated and census designated places), county subdivision, and county. Specifically this report provides critical urban and community forestry information for each state including human population characteristics and trends,...

  15. Recent changes in the deep-water fish populations of Lake Michigan

    Science.gov (United States)

    Moffett, James W.

    1957-01-01

    The deep-water fish fauna of Lake Michigan consisted of lake trout (Salvelinus namaycush), burbot (Lota lota maculosa), seven species of chubs or deep-water ciscoes (Leucichthys spp.), and the deep-water sculpin (Myoxocephalus quadricornis). Other species occupied the deep-water zone but were not typically part of the fauna.

  16. Michigan Journal of Community Service Learning. Volume 13, Number 1, Fall 2006

    Science.gov (United States)

    Howard, Jeffrey, Ed.

    2006-01-01

    The "Michigan Journal of Community Service Learning" ("MJCSL") is a national, peer-reviewed journal consisting of articles written by faculty and service-learning educators on research, theory, pedagogy, and issues pertinent to the service-learning community. The "MJCSL" aims to: (1) widen the community of…

  17. Three-question set from Michigan Neuropathy Screening Instrument adds independent prognostic information on cardiovascular outcomes

    DEFF Research Database (Denmark)

    Seferovic, Jelena P; Pfeffer, Marc A; Claggett, Brian

    2018-01-01

    AIMS/HYPOTHESIS: The self-administered Michigan Neuropathy Screening Instrument (MNSI) is used to diagnose diabetic peripheral neuropathy. We examined whether the MNSI might also provide information on risk of death and cardiovascular outcomes. METHODS: In this post hoc analysis of the Aliskiren...

  18. Use of remote sensing for land use policy formulation. [in Michigan

    Science.gov (United States)

    Boylan, M.

    1977-01-01

    The use of remotely sensed data for eliminating abuses and mismanagement of land and water resources in Michigan is discussed. Applications discussed include inventory of mosquito breeding sites; analysis of biomass in old field ecosystems used for wastewater recycling; areas for agricultural use; and preservation of the Grand Mere Dune environment. Services to users are described and contact activities reported.

  19. The Search for Equity in School Finance: Michigan School District Response to a Guaranteed Tax Base.

    Science.gov (United States)

    Park, Rolla Edward; Carroll, Stephen J.

    Part of a three-volume report on the effects of school finance reform, this volume examines the effects of reform on Michigan school districts' budgets from 1971 to 1976. Econometric models were used. Researchers found a very small "price" effect--an elasticity of -.02. The data provide no evidence that state matching grants stimulate…

  20. The Michigan Consumer Protection Act of 1976. Consumer Education Training Module.

    Science.gov (United States)

    Monsma, Charles

    This guide for secondary teachers is designed to identify and illustrate specified illegal practices identified in the Michigan Consumer Protection Act of 1976. The guide also explains procedures that a consumer or law-enforcement agency can take to enforce the provisions of this law. Since the act is a broad one, students learn not only about…

  1. Profile of winery visitors of Michigan wineries based on behavioral segmentations

    Science.gov (United States)

    Tzu-Ching Chang; Mi-Kyung Kim; Seung Hyun Kim

    2003-01-01

    Since 1995, the number of wineries and sales of Michigan wine continued to increase. In addition to wine production, the vineyards have been designed for agriculture tourism including the development of tasting rooms and winery tours. Commercial winery is more than simply grape production and has an important relationship with visitors or customers. However, little...

  2. Are Expectations Alone Enough? Estimating the Effect of a Mandatory College-Prep Curriculum in Michigan

    Science.gov (United States)

    Jacob, Brian; Dynarski, Susan; Frank, Kenneth; Schneider, Barbara

    2017-01-01

    This article examines the impacts of the Michigan Merit Curriculum (MMC), a statewide college-preparatory curriculum that applies to the high school graduating class of 2011 and later. Our analyses suggest that the higher expectations embodied in the MMC had slight impact on student outcomes. Looking at student performance in the ACT, the only…

  3. 76 FR 1338 - Emerald Ash Borer; Quarantined Areas; Maryland, Michigan, Minnesota, Missouri, Pennsylvania...

    Science.gov (United States)

    2011-01-10

    ... DEPARTMENT OF AGRICULTURE Animal and Plant Health Inspection Service 7 CFR Part 301 [Docket No. APHIS-2008-0072] Emerald Ash Borer; Quarantined Areas; Maryland, Michigan, Minnesota, Missouri..., Japan, Mongolia, the Russian Far East, Taiwan, and Canada, eventually kills healthy ash trees after it...

  4. 75 FR 81561 - Huron-Manistee National Forests, Michigan, Land and Resource Management Plan Supplemental...

    Science.gov (United States)

    2010-12-28

    ... and snowmobiling, 3. The Service's reasons for keeping certain trails open to snowmobile use were... Snowmobilers with Michigan Trail Permits (2009) by Charles Nelson; Opinions of Selected Stakeholders Concerning... possible effects of the project on tourism in the counties affected. Permits and Licenses Required The...

  5. Western Michigan University: Quasi-Revolving Fund. Green Revolving Funds in Action: Case Study Series

    Science.gov (United States)

    Billingsley, Christina

    2011-01-01

    Western Michigan University has designed an innovative "Quasi-Revolving Fund" model that demonstrates the institution's full commitment to incorporating sustainability into campus operations. The Quasi-Revolving Fund recaptures money from cost-savings, similar to a typical green revolving fund, but it also sources capital from the…

  6. Making Michigan Right-to-Work: Implementation Problems in Public Schools

    Science.gov (United States)

    Spalding, Audrey

    2014-01-01

    This paper examines how public school districts responded to Michigan's 2012 "right-to-work" law. It describes the key findings from reviews of more than 500 teacher collective bargaining agreements. It also raises several questions about the legality of some union contracts with regard to this new law. Approximately 75 percent of…

  7. Intentional, Inadvertent, or Inevitable? James Burrill Angell and Secularization at the University of Michigan.

    Science.gov (United States)

    Bouman, Jeffrey Paul

    The history of James Burrill Angell as the president of the University of Michigan presents a case study of the role of 19th century liberal Protestant university builders in the eventual marginalization of religion from the mainstream of U.S. higher education. Angell's tenure, which began in 1871, encompassed the period in which the modern…

  8. Reliability and Validity of Michigan School Libraries for the 21st Century Measurement Benchmarks

    Science.gov (United States)

    Floyd, Natosha N.

    2016-01-01

    The purpose of this study was to examine the psychometric properties of the Michigan School Libraries for the 21st Century Measurement Benchmarks (SL21). The instrument consists of 19 items with three subscales: Building the 21st Century Learning Environment Subscale, Teaching for 21st Century Learning Subscale, and Leading the Way to 21st Century…

  9. 78 FR 8478 - Approval and Promulgation of Air Quality Implementation Plans; States of Michigan and Minnesota...

    Science.gov (United States)

    2013-02-06

    ...'s electric generating units, whereas its December 2009 plan determines BART on a plant-by-plant... zones of any grate-kiln taconite furnace. Therefore, this option is not technically feasible.'' Michigan... the indurating zones of two grate- kiln furnaces. These applications were found not to have adverse...

  10. Follow the Money: An Initial Review of Elementary Charter School Spending in Michigan.

    Science.gov (United States)

    Prince, Hank

    1999-01-01

    Examined whether Michigan's elementary charter schools' expenditures differ from those of comparable-enrollment local districts. During 1995-96, charters spent an average of 57 percent of revenues on instruction and about 43 percent on support services, compared to 65 and 35 percent for comparable districts. Charters' administrative expenditures…

  11. Service to the Electric Utility Industry by the Ford Nuclear Reactor, University of Michigan

    International Nuclear Information System (INIS)

    Burn, R.R.; Simpson, P.A.; Cook, G.M.

    1993-01-01

    Since 1977, the staff of the University of Michigan's Ford Nuclear Reactor has been providing irradiation, testing, analytical, and training services to electric utilities and to suppliers of the nuclear electric utility industry. This paper discusses the reactor's irradiation facilities; reactor programs and utilization; materials testing programs; neutron activation analysis activities; and training programs conducted

  12. Do mtDNA Deletions Play a Role in the Development of Nasal Polyposis?

    Directory of Open Access Journals (Sweden)

    Arzu Tatar

    2014-04-01

    Full Text Available Objective:Nasal polyposis (NP is an inflammatory disease of the nasal mucosa and paranasal sinuses. Mitochondria are the cellular organelles which produce cellular energy by Oxidative Phosphorylation (OXPHOS, and they have own inheritance material, mtDNA. mtDNA is affected by reactive oxygen samples (ROS which are produced by both OXPHOS and the inflammatory process. The aim of this study was to investigate the 4977 bp and 7400 bp deletions of mtDNA in nasal polyposis tissue, and to indicate the possible association of mtDNA deletions with NP. Methods:Thirty-three patients, aged 15 to 65 years, with nasal polyposis were selected to be assessed for mitochondrial DNA deletions. The patients with possible mtDNA mutations due to mitochondrial disease, being treated with radiotherapy, of advanced age, with a familiar history, aspirin hypersensitivity, or a history of asthma, were excluded. Polyp excision surgery was applied to the treatment of the NP, and after histopathological diagnosis 1x1 cm of polyp tissue samples were used to isolate mtDNA. The 4977 bp and 7400 bp deletion regions, and two control regions of mtDNA were assessed by using four pairs of primers. DNA extractions from the NP tissues and peripheral blood samples of the patients were made, and then Polymerase Chain Reactions (PCR were made. PCR products were separated in 2% agarose gel.Results:No patient had either the 4977 bp deletion or the 7400 bp deletion in their NP tissue, and neither were these deletions evident in their peripheral blood. Two control sequences, one of them from a non-deleted region, and the other from a possible deletion region, were detected in the NP tissues and peripheral blood of all the patients.Conclusions:We had anticipated that some mtDNA deletion might have occurred in NP tissue due to the increased ROS levels caused by chronic inflammation, but we did not detect any deletion. Probably, the duration of inflammation in NP is insufficient to form mt

  13. Re-interpreting the Oxbridge stransverse mass variable MT2 in general cases

    CERN Document Server

    Mahbubani, Rakhi; Park, Myeonghun

    2013-01-01

    We extend the range of possible applications of MT2 type analyses to decay chains with multiple invisible particles, as well as to asymmetric event topologies with different parent and/or different children particles. We advocate two possible approaches. In the first, we introduce suitably defined 3+1-dimensional analogues of the MT2 variable, which take into account all relevant on-shell kinematic constraints in a given event topology. The second approach utilizes the conventional MT2 variable, but its kinematic endpoint is suitably reinterpreted on a case by case basis, depending on the specific event topology at hand. We provide the general prescription for this reinterpretation, including the formulas relating the measured MT2 endpoint (as a function of the test masses of all the invisible particles) to the underlying physical mass spectrum. We also provide analytical formulas for the shape of the differential distribution of the doubly projected MT2(perp) variable for the ten possible event topologies wi...

  14. Impact of Sleeping Altitude on Symptoms of Acute Mountain Sickness on Mt. Fuji.

    Science.gov (United States)

    Horiuchi, Masahiro; Uno, Tadashi; Endo, Junko; Handa, Yoko; Hasegawa, Tatsuya

    2018-05-09

    Horiuchi, Masahiro, Tadashi Uno, Junko Endo, Yoko Handa, and Tatsuya Hasegawa. Impact of sleeping altitude on symptoms of acute mountain sickness on Mt. Fuji. High Alt Med Biol. 00:000-000, 2018. We sought to investigate the factors influencing acute mountain sickness (AMS) on Mt. Fuji in Japan, in particular, to assess the effects of sleeping altitude, by means of a questionnaire survey. This study involved 1932 participants who climbed Mt. Fuji, and obtained information regarding sex, age, and whether participants stayed at the mountain lodges. The AMS survey excluded the perceived sleep difficulties assessed with the Lake Louise Scoring (LLS) system for all climbers. The overall prevalence of AMS was 31.6% for all participants (LLS score ≥3 with headache, excluding sleep difficulties). A univariate analysis revealed that overnight stay at Mt. Fuji was associated with an increased prevalence of AMS, but that sex and age were not. For overnight lodgers, the mean sleeping altitude in participants with AMS was slightly higher than that in participants without AMS (p lodge, especially one above 2870 m, may be associated with an increased prevalence of AMS on Mt. Fuji.

  15. Three-dimensional interpretation of MT data in volcanic environments (computer simulation)

    Energy Technology Data Exchange (ETDEWEB)

    Spichak, V. [Geoelectromagnetic Research Institute RAS, Troitsk, Moscow (Russian Federation)

    2001-04-01

    The research is aimed, first, to find components of MT-fields and their transforms, which facilitate the imaging of the internal structure of volcanoes and, second, to study the detectability of conductivity variations in a magma chamber due to alterations of other physical parameters. The resolving power of MT data with respect to the electric structure of volcanic zones is studied using software developed by the author for three-dimensional (3D) numerical modeling, analysis and imaging. A set of 3D volcano models are constructed and synthetic MT data on the relief Earth's surface are analysed. It is found that impedance phases as well as in-phase and quadrature parts of the electric field type transforms enable the best imaging of the volcanic interior. The determinant impedance is, however, the most suitable for adequate interpretation of measurements carried out for the purpose of monitoring conductivity variations in a magma chamber. The way of removing the geological noise from the MT data by means of its upward analytical continuation to the artificial reference plane is discussed. Interpretation methodologies are suggested aimed at 3D imaging and monitoring volcanic interiors by MT data.

  16. Inspecting close maternal relatedness: Towards better mtDNA population samples in forensic databases.

    Science.gov (United States)

    Bodner, Martin; Irwin, Jodi A; Coble, Michael D; Parson, Walther

    2011-03-01

    Reliable data are crucial for all research fields applying mitochondrial DNA (mtDNA) as a genetic marker. Quality control measures have been introduced to ensure the highest standards in sequence data generation, validation and a posteriori inspection. A phylogenetic alignment strategy has been widely accepted as a prerequisite for data comparability and database searches, for forensic applications, for reconstructions of human migrations and for correct interpretation of mtDNA mutations in medical genetics. There is continuing effort to enhance the number of worldwide population samples in order to contribute to a better understanding of human mtDNA variation. This has often lead to the analysis of convenience samples collected for other purposes, which might not meet the quality requirement of random sampling for mtDNA data sets. Here, we introduce an additional quality control means that deals with one aspect of this limitation: by combining autosomal short tandem repeat (STR) marker with mtDNA information, it helps to avoid the bias introduced by related individuals included in the same (small) sample. By STR analysis of individuals sharing their mitochondrial haplotype, pedigree construction and subsequent software-assisted calculation of likelihood ratios based on the allele frequencies found in the population, closely maternally related individuals can be identified and excluded. We also discuss scenarios that allow related individuals in the same set. An ideal population sample would be representative for its population: this new approach represents another contribution towards this goal. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  17. The past, present and future of mitochondrial genomics: have we sequenced enough mtDNAs?

    Science.gov (United States)

    Smith, David Roy

    2016-01-01

    The year 2014 saw more than a thousand new mitochondrial genome sequences deposited in GenBank-an almost 15% increase from the previous year. Hundreds of peer-reviewed articles accompanied these genomes, making mitochondrial DNAs (mtDNAs) the most sequenced and reported type of eukaryotic chromosome. These mtDNA data have advanced a wide range of scientific fields, from forensics to anthropology to medicine to molecular evolution. But for many biological lineages, mtDNAs are so well sampled that newly published genomes are arguably no longer contributing significantly to the progression of science, and in some cases they are tying up valuable resources, particularly journal editors and referees. Is it time to acknowledge that as a research community we have published enough mitochondrial genome papers? Here, I address this question, exploring the history, milestones and impacts of mitochondrial genomics, the benefits and drawbacks of continuing to publish mtDNAs at a high rate and what the future may hold for such an important and popular genetic marker. I highlight groups for which mtDNAs are still poorly sampled, thus meriting further investigation, and recommend that more energy be spent characterizing aspects of mitochondrial genomes apart from the DNA sequence, such as their chromosomal and transcriptional architectures. Ultimately, one should be mindful before writing a mitochondrial genome paper. Consider perhaps sending the sequence directly to GenBank instead, and be sure to annotate it correctly before submission. © The Author 2015. Published by Oxford University Press.

  18. Membrane-type-3 matrix metalloproteinase (MT3-MMP functions as a matrix composition-dependent effector of melanoma cell invasion.

    Directory of Open Access Journals (Sweden)

    Olga Tatti

    Full Text Available In primary human melanoma, the membrane-type matrix metalloproteinase, MT3-MMP, is overexpressed in the most aggressive nodular-type tumors. Unlike MT1-MMP and MT2-MMP, which promote cell invasion through basement membranes and collagen type I-rich tissues, the function of MT3-MMP in tumor progression remains unclear. Here, we demonstrate that MT3-MMP inhibits MT1-MMP-driven melanoma cell invasion in three-dimensional collagen, while yielding an altered, yet MT1-MMP-dependent, form of expansive growth behavior that phenocopies the formation of nodular cell colonies. In melanoma cell lines originating from advanced primary or metastatic lesions, endogenous MT3-MMP expression was associated with limited collagen-invasive potential. In the cell lines with highest MT3-MMP expression relative to MT1-MMP, collagen-invasive activity was increased following stable MT3-MMP gene silencing. Consistently, MT3-MMP overexpression in cells derived from less advanced superficially spreading melanoma lesions, or in the MT3-MMP knockdown cells, reduced MT1-MMP-dependent collagen invasion. Rather than altering MT1-MMP transcription, MT3-MMP interacted with MT1-MMP in membrane complexes and reduced its cell surface expression. By contrast, as a potent fibrinolytic enzyme, MT3-MMP induced efficient invasion of the cells in fibrin, a provisional matrix component frequently found at tumor-host tissue interfaces and perivascular spaces of melanoma. Since MT3-MMP was significantly upregulated in biopsies of human melanoma metastases, these results identify MT3-MMP as a matrix-dependent modifier of the invasive tumor cell functions during melanoma progression.

  19. Changes in the Lake Michigan food web following dreissenid mussel invasions: A synthesis

    Science.gov (United States)

    Madenjian, Charles P.; Bunnell, David B.; Warner, David M.; Pothoven, Steven A.; Fahnenstiel, Gary L.; Nalepa, Thomas F.; Vanderploeg, Henry A.; Tsehaye, Iyob; Claramunt, Randall M.; Clark, Richard D

    2015-01-01

    Using various available time series for Lake Michigan, we examined changes in the Lake Michigan food web following the dreissenid mussel invasions and identified those changes most likely attributable to these invasions, thereby providing a synthesis. Expansion of the quagga mussel (Dreissena rostriformis bugensis) population into deeper waters, which began around 2004, appeared to have a substantial predatory effect on both phytoplankton abundance and primary production, with annual primary production in offshore (> 50 m deep) waters being reduced by about 35% by 2007. Primary production likely decreased in nearshore waters as well, primarily due to predatory effects exerted by the quagga mussel expansion. The drastic decline inDiporeia abundance in Lake Michigan during the 1990s and 2000s has been attributed to dreissenid mussel effects, but the exact mechanism by which the mussels were negatively affecting Diporeia abundance remains unknown. In turn, decreased Diporeiaabundance was associated with reduced condition, growth, and/or energy density in alewife (Alosa pseudoharengus), lake whitefish (Coregonus clupeaformis), deepwater sculpin (Myoxocephalus thompsonii), and bloater (Coregonus hoyi). However, lake-wide biomass of salmonines, top predators in the food web, remained high during the 2000s, and consumption of alewives by salmonines actually increased between the 1980–1995 and 1996–2011 time periods. Moreover, abundance of the lake whitefish population, which supports Lake Michigan's most valuable commercial fishery, remained at historically high levels during the 2000s. Apparently, counterbalancing mechanisms operating within the complex Lake Michigan food web have enabled salmonines and lake whitefish to retain relatively high abundances despite reduced primary production.

  20. Evidence of animal mtDNA recombination between divergent populations of the potato cyst nematode Globodera pallida.

    Science.gov (United States)

    Hoolahan, Angelique H; Blok, Vivian C; Gibson, Tracey; Dowton, Mark

    2012-03-01

    Recombination is typically assumed to be absent in animal mitochondrial genomes (mtDNA). However, the maternal mode of inheritance means that recombinant products are indistinguishable from their progenitor molecules. The majority of studies of mtDNA recombination assess past recombination events, where patterns of recombination are inferred by comparing the mtDNA of different individuals. Few studies assess contemporary mtDNA recombination, where recombinant molecules are observed as direct mosaics of known progenitor molecules. Here we use the potato cyst nematode, Globodera pallida, to investigate past and contemporary recombination. Past recombination was assessed within and between populations of G. pallida, and contemporary recombination was assessed in the progeny of experimental crosses of these populations. Breeding of genetically divergent organisms may cause paternal mtDNA leakage, resulting in heteroplasmy and facilitating the detection of recombination. To assess contemporary recombination we looked for evidence of recombination between the mtDNA of the parental populations within the mtDNA of progeny. Past recombination was detected between a South American population and several UK populations of G. pallida, as well as between two South American populations. This suggests that these populations may have interbred, paternal mtDNA leakage occurred, and the mtDNA of these populations subsequently recombined. This evidence challenges two dogmas of animal mtDNA evolution; no recombination and maternal inheritance. No contemporary recombination between the parental populations was detected in the progeny of the experimental crosses. This supports current arguments that mtDNA recombination events are rare. More sensitive detection methods may be required to adequately assess contemporary mtDNA recombination in animals.

  1. Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis

    DEFF Research Database (Denmark)

    List, Karin; Haudenschild, Christian C; Szabo, Roman

    2002-01-01

    of Matriptase/MT-SP1 also seriously affected hair follicle development resulting in generalized follicular hypoplasia, absence of erupted vibrissae, lack of vibrissal hair canal formation, ingrown vibrissae, and wholesale abortion of vibrissal follicles. Furthermore, Matriptase/MT-SP1-deficiency resulted...... in dramatically increased thymocyte apoptosis, and depletion of thymocytes. This study demonstrates that Matriptase/MT-SP1 has pleiotropic functions in the development of the epidermis, hair follicles, and cellular immune system....

  2. Metallogeny, exploitation and environmental impact of the Mt. Amiata mercury ore district (Southern Tuscany, Italy)

    Science.gov (United States)

    Rimondi, V.; Chiarantini, L.; Lattanzi, P.; Benvenuti, M.; Beutel, M.; Colica, A.; Costagliola, P.; Di Benedetto, F.; Gabbani, G.; Gray, John E.; Pandeli, E.; Pattelli, G.; Paolieri, M.; Ruggieri, G.

    2015-01-01

    The Mt. Amiata mining district (Southern Tuscany, Italy) is a world class Hg district, with a cumulate production of more than 100,000 tonnes of Hg, mostly occurring between 1870 and 1980. The Hg mineralization at Mt. Amiata is younger than 0.3 Ma, and is directly related to shallow hydrothermal systems similar to present-day geothermal fields of the region. There is likely a continuum of Hg deposition to present day, because Hg emission from geothermal power plants is on-going. In this sense, the Mt. Amiata deposits present some analogies with “hot-spring type” deposits of western USA, although an ore deposit model for the district has not been established. Specifically, the source of Hg remains highly speculative. The mineralizing hydrothermal fluids are of low temperature, and of essentially meteoric origin.

  3. Land, language, and loci: mtDNA in Native Americans and the genetic history of Peru.

    Science.gov (United States)

    Lewis, Cecil M; Tito, Raúl Y; Lizárraga, Beatriz; Stone, Anne C

    2005-07-01

    Despite a long history of complex societies and despite extensive present-day linguistic and ethnic diversity, relatively few populations in Peru have been sampled for population genetic investigations. In order to address questions about the relationships between South American populations and about the extent of correlation between genetic distance, language, and geography in the region, mitochondrial DNA (mtDNA) hypervariable region I sequences and mtDNA haplogroup markers were examined in 33 individuals from the state of Ancash, Peru. These sequences were compared to those from 19 American Indian populations using diversity estimates, AMOVA tests, mismatch distributions, a multidimensional scaling plot, and regressions. The results show correlations between genetics, linguistics, and geographical affinities, with stronger correlations between genetics and language. Additionally, the results suggest a pattern of differential gene flow and drift in western vs. eastern South America, supporting previous mtDNA and Y chromosome investigations. (c) 2004 Wiley-Liss, Inc

  4. Special issue “The phreatic eruption of Mt. Ontake volcano in 2014”

    Science.gov (United States)

    Yamaoka, Koshun; Geshi, Nobuo; Hashimoto, Tasheki; Ingebritsen, Steven E.; Oikawa, Teruki

    2016-01-01

    Mt. Ontake volcano erupted at 11:52 on September 27, 2014, claiming the lives of at least 58 hikers. This eruption was the worst volcanic disaster in Japan since the 1926 phreatic eruption of Mt. Tokachidake claimed 144 lives (Table 1). The timing of the eruption contributed greatly to the heavy death toll: near midday, when many hikers were near the summit, and during a weekend of clear weather conditions following several rainy weekends. The importance of this timing is reflected by the fact that a somewhat larger eruption of Mt. Ontake in 1979 resulted in injuries but no deaths. In 2014, immediate precursors were detected with seismometers and tiltmeters about 10 min before the eruption, but the eruption started before a warning was issued.

  5. Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP

    DEFF Research Database (Denmark)

    Ingvarsen, Signe; Porse, Astrid; Erpicum, Charlotte

    2013-01-01

    and pathological events, has been complicated by the lack of specific inhibitors and the fact that some of the potent MMPs are multifunctional enzymes. These factors have also hampered the setup of therapeutic strategies targeting MMP activity. A tempting target is the membrane-associated MT1-MMP, which has well......-documented importance in matrix degradation but which takes part in more than one pathway in this regard. In this report, we describe the selective targeting of a single function of this enzyme by means of a specific monoclonal antibody against MT1-MMP, raised in an MT1-MMP knock-out mouse. The antibody blocks...... matrix in vitro, as well as in lymphatic vessel sprouting assayed ex vivo. This is the first example of the complete inactivation of a single function of a multifunctional MMP and the use of this strategy to pursue its role....

  6. Canis mtDNA HV1 database: a web-based tool for collecting and surveying Canis mtDNA HV1 haplotype in public database.

    Science.gov (United States)

    Thai, Quan Ke; Chung, Dung Anh; Tran, Hoang-Dung

    2017-06-26

    Canine and wolf mitochondrial DNA haplotypes, which can be used for forensic or phylogenetic analyses, have been defined in various schemes depending on the region analyzed. In recent studies, the 582 bp fragment of the HV1 region is most commonly used. 317 different canine HV1 haplotypes have been reported in the rapidly growing public database GenBank. These reported haplotypes contain several inconsistencies in their haplotype information. To overcome this issue, we have developed a Canis mtDNA HV1 database. This database collects data on the HV1 582 bp region in dog mitochondrial DNA from the GenBank to screen and correct the inconsistencies. It also supports users in detection of new novel mutation profiles and assignment of new haplotypes. The Canis mtDNA HV1 database (CHD) contains 5567 nucleotide entries originating from 15 subspecies in the species Canis lupus. Of these entries, 3646 were haplotypes and grouped into 804 distinct sequences. 319 sequences were recognized as previously assigned haplotypes, while the remaining 485 sequences had new mutation profiles and were marked as new haplotype candidates awaiting further analysis for haplotype assignment. Of the 3646 nucleotide entries, only 414 were annotated with correct haplotype information, while 3232 had insufficient or lacked haplotype information and were corrected or modified before storing in the CHD. The CHD can be accessed at http://chd.vnbiology.com . It provides sequences, haplotype information, and a web-based tool for mtDNA HV1 haplotyping. The CHD is updated monthly and supplies all data for download. The Canis mtDNA HV1 database contains information about canine mitochondrial DNA HV1 sequences with reconciled annotation. It serves as a tool for detection of inconsistencies in GenBank and helps identifying new HV1 haplotypes. Thus, it supports the scientific community in naming new HV1 haplotypes and to reconcile existing annotation of HV1 582 bp sequences.

  7. Accumulation of pathogenic ΔmtDNA induced deafness but not diabetic phenotypes in mito-mice

    International Nuclear Information System (INIS)

    Nakada, Kazuto; Sato, Akitsugu; Sone, Hideyuki; Kasahara, Atsuko; Ikeda, Katsuhisa; Kagawa, Yasuo; Yonekawa, Hiromichi; Hayashi, Jun-Ichi

    2004-01-01

    Mito-mice carrying various proportions of deletion mutant mtDNA (ΔmtDNA) were generated by introduction of the ΔmtDNA from cultured cells into fertilized eggs of C57BL/6J (B6) strain mice. Great advantages of mito-mice are that they share exactly the same nuclear-genome background, and that their genetic variations are restricted to proportions of pathogenic ΔmtDNA. Since accumulation of ΔmtDNA to more than 75% induced respiration defects, the disease phenotypes observed exclusively in mito-mice carrying more than 75% ΔmtDNA should be due to accumulated ΔmtDNA. In this study, we focused on the expressions of hearing loss and diabetic phenotypes, since these common age-associated abnormalities have sometimes been reported to be inherited maternally and to be associated with pathogenic mutant mtDNAs. The results showed that accumulation of exogenously introduced ΔmtDNA was responsible for hearing loss, but not for expression of diabetic phenotypes in mito-mice

  8. Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance: transgenic TK2, mtDNA, and antiretrovirals.

    Science.gov (United States)

    Hosseini, Seyed H; Kohler, James J; Haase, Chad P; Tioleco, Nina; Stuart, Tami; Keebaugh, Erin; Ludaway, Tomika; Russ, Rodney; Green, Elgin; Long, Robert; Wang, Liya; Eriksson, Staffan; Lewis, William

    2007-03-01

    Mitochondrial toxicity limits nucleoside reverse transcriptase inhibitors (NRTIs) for acquired immune deficiency syndrome. NRTI triphosphates, the active moieties, inhibit human immunodeficiency virus reverse transcriptase and eukaryotic mitochondrial DNA polymerase pol-gamma. NRTI phosphorylation seems to correlate with mitochondrial toxicity, but experimental evidence is lacking. Transgenic mice (TGs) with cardiac overexpression of thymidine kinase isoforms (mitochondrial TK2 and cytoplasmic TK1) were used to study NRTI mitochondrial toxicity. Echocardiography and nuclear magnetic resonance imaging defined cardiac performance and structure. TK gene copy and enzyme activity, mitochondrial (mt) DNA and polypeptide abundance, succinate dehydrogenase and cytochrome oxidase histochemistry, and electron microscopy correlated with transgenesis, mitochondrial structure, and biogenesis. Antiretroviral combinations simulated therapy. Untreated hTK1 or TK2 TGs exhibited normal left ventricle mass. In TK2 TGs, cardiac TK2 gene copy doubled, activity increased 300-fold, and mtDNA abundance doubled. Abundance of the 17-kd subunit of complex I, succinate dehydrogenase histochemical activity, and cristae density increased. NRTIs increased left ventricle mass 20% in TK2 TGs. TK activity increased 3 logs in hTK1 TGs, but no cardiac phenotype resulted. NRTIs abrogated functional effects of transgenically increased TK2 activity but had no effect on TK2 mtDNA abundance. Thus, NRTI mitochondrial phosphorylation by TK2 is integral to clinical NRTI mitochondrial toxicity.

  9. Comparison of minichromosome maintenance proteins (MCM-3, MCM-7) and metallothioneins (MT-I/II, MT-III) expression in relation to clinicopathological data in ovarian cancer.

    Science.gov (United States)

    Kobierzycki, Christopher; Pula, Bartosz; Skiba, Mateusz; Jablonska, Karolina; Latkowski, Krzysztof; Zabel, Maciej; Nowak-Markwitz, Ewa; Spaczynski, Marek; Kedzia, Witold; Podhorska-Okolow, Marzena; Dziegiel, Piotr

    2013-12-01

    Despite great progress in the understanding of ovarian cancer biology, clinicopathological data (i.e. grade, stage, histological type and residual disease after surgery) seem to be the most important prognostic factors. The present study aimed to investigate the relationship between expression of minichromosome maintenance proteins (MCM-3, MCM-7), metallothioneins (MT-I/II, MT-III), and Ki-67 in 103 ovarian cancer cases, mostly of the serous histological type. Statistical analysis revealed strong positive correlations in the expression of MCM-3 vs. Ki-67 (r=0.492), MCM-7 vs. Ki-67 (r=0.651), and MCM-3 vs. MCM-7 (r=0.515) (all pMCM-3 and Ki-67 with increasing grade of histological malignancy (p=0.0011, p=0.029, respectively). Regarding clinical progression, cytoplasmic MT-I/II expression was significantly higher in more advanced disease stages (III+IV vs. I+II; p=0.0247). Due to the correlations shown here, the determination of MCM proteins as proliferation markers of ovarian cancer, should be strongly considered.

  10. Static shift correction of MT data in Tohoku district using TEM soundings; TEM ho data wo mochiita Tohoku chiho MT ho data no statistic shift hosei

    Energy Technology Data Exchange (ETDEWEB)

    Kawakami, N; Kumekawa, Y; Miura, Y; Takasugi, S [GERD Geothermal Energy Research and Development Co. Ltd., Tokyo (Japan); Fujinawa, Y [National Research Institute for Disaster Prevention, Tsukuba (Japan)

    1997-05-27

    There is a possibility that the wide-band MT observation data obtained in the central part of Tohoku district include the static shift effect. To grasp the static shift effect in the MT data, the TEM soundings were conducted at all the site where the MT data were measured. The TEM sounding system was developed for the shallow survey depth ranging from 5 m to 150 m. When showing the measured results on the histogram, it was found that the static shifts were concentrated in the vicinity of zero. About 70% of the data was below 0.2 decade. Only a slight static shift effect was observed. This means that the results obtained by the two-dimensional analysis are plausible. Especially, the static shift around plain was small. Therefore, the current results around the plain were trustful. On the other hand, the static shift in the mountainous area was rather large. Accordingly, the results around the mountainous area should be carefully treated. 7 refs., 10 figs.

  11. DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated?

    Directory of Open Access Journals (Sweden)

    Alessandra eMaresca

    2015-03-01

    Full Text Available Autosomal dominant cerebellar ataxia, deafness and narcolepsy (ADCA-DN and Hereditary sensory neuropathy with dementia and hearing loss (HSN1E are two rare, overlapping neurodegenerative syndromes that have been recently linked to allelic dominant pathogenic mutations in the DNMT1 gene, coding for DNA (cytosine-5-methyltransferase 1. DNMT1 is the enzyme responsible for maintaining the nuclear genome methylation patterns during the DNA replication and repair, thus regulating gene expression. The mutations responsible for ADCA-DN and HSN1E affect the replication foci targeting sequence domain, which regulates DNMT1 binding to chromatin. DNMT1 dysfunction is anticipated to lead to a global alteration of the DNA methylation pattern with predictable downstream consequences on gene expression. Interestingly, ADCA-DN and HSN1E phenotypes share some clinical features typical of mitochondrial diseases, such as optic atrophy, peripheral neuropathy and deafness, and some biochemical evidence of mitochondrial dysfunction. The recent discovery of a mitochondrial isoform of DNMT1 and its proposed role in methylating mitochondrial DNA (mtDNA suggests that DNMT1 mutations may directly affect mtDNA and mitochondrial physiology. On the basis of this latter finding the link between DNMT1 abnormal activity and mitochondrial dysfunction in ADCA-DN and HSN1E appears intuitive, however mtDNA methylation remains highly debated. In the last years several groups demonstrated the presence of 5-methylcytosine in mtDNA by different approaches, but, on the other end, the opposite evidence that mtDNA is not methylated has also been published. Since over 1500 mitochondrial proteins are encoded by the nuclear genome, the altered methylation of these genes may well have a critical role in leading to the mitochondrial impairment observed in ADCA-DN and HSN1E. Thus, many open questions still remain unanswered, such as why mtDNA should be methylated, and how this process is

  12. Modeling variably saturated subsurface solute transport with MODFLOW-UZF and MT3DMS

    Science.gov (United States)

    Morway, Eric D.; Niswonger, Richard G.; Langevin, Christian D.; Bailey, Ryan T.; Healy, Richard W.

    2013-01-01

    The MT3DMS groundwater solute transport model was modified to simulate solute transport in the unsaturated zone by incorporating the unsaturated-zone flow (UZF1) package developed for MODFLOW. The modified MT3DMS code uses a volume-averaged approach in which Lagrangian-based UZF1 fluid fluxes and storage changes are mapped onto a fixed grid. Referred to as UZF-MT3DMS, the linked model was tested against published benchmarks solved analytically as well as against other published codes, most frequently the U.S. Geological Survey's Variably-Saturated Two-Dimensional Flow and Transport Model. Results from a suite of test cases demonstrate that the modified code accurately simulates solute advection, dispersion, and reaction in the unsaturated zone. Two- and three-dimensional simulations also were investigated to ensure unsaturated-saturated zone interaction was simulated correctly. Because the UZF1 solution is analytical, large-scale flow and transport investigations can be performed free from the computational and data burdens required by numerical solutions to Richards' equation. Results demonstrate that significant simulation runtime savings can be achieved with UZF-MT3DMS, an important development when hundreds or thousands of model runs are required during parameter estimation and uncertainty analysis. Three-dimensional variably saturated flow and transport simulations revealed UZF-MT3DMS to have runtimes that are less than one tenth of the time required by models that rely on Richards' equation. Given its accuracy and efficiency, and the wide-spread use of both MODFLOW and MT3DMS, the added capability of unsaturated-zone transport in this familiar modeling framework stands to benefit a broad user-ship.

  13. A Signal, from Human mtDNA, of Postglacial Recolonization in Europe

    Science.gov (United States)

    Torroni, Antonio; Bandelt, Hans-Jürgen; Macaulay, Vincent; Richards, Martin; Cruciani, Fulvio; Rengo, Chiara; Martinez-Cabrera, Vicente; Villems, Richard; Kivisild, Toomas; Metspalu, Ene; Parik, Jüri; Tolk, Helle-Viivi; Tambets, Kristiina; Forster, Peter; Karger, Bernd; Francalacci, Paolo; Rudan, Pavao; Janicijevic, Branka; Rickards, Olga; Savontaus, Marja-Liisa; Huoponen, Kirsi; Laitinen, Virpi; Koivumäki, Satu; Sykes, Bryan; Hickey, Eileen; Novelletto, Andrea; Moral, Pedro; Sellitto, Daniele; Coppa, Alfredo; Al-Zaheri, Nadia; Santachiara-Benerecetti, A. Silvana; Semino, Ornella; Scozzari, Rosaria

    2001-01-01

    Mitochondrial HVS-I sequences from 10,365 subjects belonging to 56 populations/geographical regions of western Eurasia and northern Africa were first surveyed for the presence of the T→C transition at nucleotide position 16298, a mutation which has previously been shown to characterize haplogroup V mtDNAs. All mtDNAs with this mutation were then screened for a number of diagnostic RFLP sites, revealing two major subsets of mtDNAs. One is haplogroup V proper, and the other has been termed “pre*V,” since it predates V phylogenetically. The rather uncommon pre*V tends to be scattered throughout Europe (and northwestern Africa), whereas V attains two peaks of frequency: one situated in southwestern Europe and one in the Saami of northern Scandinavia. Geographical distributions and ages support the scenario that pre*V originated in Europe before the Last Glacial Maximum (LGM), whereas the more recently derived haplogroup V arose in a southwestern European refugium soon after the LGM. The arrival of V in eastern/central Europe, however, occurred much later, possibly with (post-)Neolithic contacts. The distribution of haplogroup V mtDNAs in modern European populations would thus, at least in part, reflect the pattern of postglacial human recolonization from that refugium, affecting even the Saami. Overall, the present study shows that the dissection of mtDNA variation into small and well-defined evolutionary units is an essential step in the identification of spatial frequency patterns. Mass screening of a few markers identified using complete mtDNA sequences promises to be an efficient strategy for inferring features of human prehistory. PMID:11517423

  14. Episodic weakness due to mitochondrial DNA MT-ATP6/8 mutations.

    Science.gov (United States)

    Auré, Karine; Dubourg, Odile; Jardel, Claude; Clarysse, Lucie; Sternberg, Damien; Fournier, Emmanuel; Laforêt, Pascal; Streichenberger, Nathalie; Petiot, Philippe; Gervais-Bernard, Hélène; Vial, Christophe; Bedat-Millet, Anne-Laure; Drouin-Garraud, Valérie; Bouillaud, Frédéric; Vandier, Christophe; Fontaine, Bertrand; Lombès, Anne

    2013-11-19

    To report that homoplasmic deleterious mutations in the mitochondrial DNA MT-ATP6/8 genes may be responsible for acute episodes of limb weakness mimicking periodic paralysis due to channelopathies and dramatically responding to acetazolamide. Mitochondrial DNA sequencing and restriction PCR, oxidative phosphorylation functional assays, reactive oxygen species metabolism, and patch-clamp technique in cultured skin fibroblasts. Occurrence of a typical MELAS (mitochondrial encephalopathy with lactic acidosis and stroke-like episodes) syndrome in a single member of a large pedigree with episodic weakness associated with a later-onset distal motor neuropathy led to the disclosure of 2 deleterious mitochondrial DNA mutations. The MT-ATP6 m.9185T>C p.Leu220Pro mutation, previously associated with Leigh syndrome, was present in all family members, while the MT-TL1 m.3271T>C mutation, a known cause of MELAS syndrome, was observed in the sole patient with MELAS presentation. Significant defect of complexes V and I as well as oxidative stress were observed in both primary fibroblasts and cybrid cells with 100% m.9185T>C mutation. Permanent plasma membrane depolarization and altered permeability to K(+) in fibroblasts provided a link with the paralysis episodes. Screening of 9 patients, based on their clinical phenotype, identified 4 patients with similar deleterious MT-ATP6 mutations (twice m.9185T>C and once m.9176T>C or m.8893T>C). A fifth patient presented with an original potentially deleterious MT-ATP8 mutation (m.8403T>C). All mutations were associated with almost-normal complex V activity but significant oxidative stress and permanent plasma membrane depolarization. Homoplasmic mutations in the MT-ATP6/8 genes may cause episodic weakness responding to acetazolamide treatment.

  15. Joint inversion of marine MT and CSEM data over Gemini prospect, Gulf of Mexico

    Science.gov (United States)

    Constable, S.; Orange, A. S.; Key, K.

    2013-12-01

    In 2003 we tested a prototype marine controlled-source electromagnetic (CSEM) transmitter over the Gemini salt body in the Gulf of Mexico, collecting one line of data over 15 seafloor receiver instruments using the Cox waveform with a 0.25 Hz fundamental, yielding 3 usable frequencies. Transmission current was 95 amps on a 150 m antenna. We had previously collected 16 sites of marine magnetotelluric (MT) data along this line during the development of broadband marine MT as a tool for mapping salt geometry. Recently we commissioned a finite element code capable of joint CSEM and MT 2D inversion incorporating bathymetry and anisotropy, and this heritage data set provided an opportunity to explore such inversions with real data. We reprocessed the CSEM data to obtain objective error estimates and inverted single frequency CSEM, multi-frequency CSEM, MT, and joint MT and CSEM data sets for a variety of target misfits, using the Occam regularized inversion algorithm. As expected, MT-only inversions produce a smoothed image of the salt and a resistive basement at 9 km depth. The CSEM data image a conductive cap over the salt body and have little sensitivity to the salt or structure at depths beyond about 1500 m below seafloor. However, the joint inversion yields more than the sum of the parts - the outline of the salt body is much sharper and there is much more structural detail even at depths beyond the resolution of the CSEM data. As usual, model complexity greatly depends on target misfit, and even with well-estimated errors the choice of misfit becomes a somewhat subjective decision. Our conclusion is a familiar one; more data are always good.

  16. Joint 3D Inversion of ZTEM Airborne and Ground MT Data with Application to Geothermal Exploration

    Science.gov (United States)

    Wannamaker, P. E.; Maris, V.; Kordy, M. A.

    2017-12-01

    ZTEM is an airborne electromagnetic (EM) geophysical technique developed by Geotech Inc® where naturally propagated EM fields originating with regional and global lightning discharges (sferics) are measured as a means of inferring subsurface electrical resistivity structure. A helicopter-borne coil platform (bird) measuring the vertical component of magnetic (H) field variations along a flown profile is referenced to a pair of horizontal coils at a fixed location on the ground in order to estimate a tensor H-field transfer function. The ZTEM method is distinct from the traditional magnetotelluric (MT) method in that the electric (E) fields are not considered because of the technological challenge of measuring E-fields in the dielectric air medium. This can lend some non-uniqueness to ZTEM interpretation because a range of conductivity structures in the earth depending upon an assumed background earth resistivity model can fit ZTEM data to within tolerance. MT data do not suffer this particular problem, but they are cumbersome to acquire in their common need for land-based transport often in near-roadless areas and for laying out and digging the electrodes and H coils. The complementary nature of ZTEM and MT logistics and resolution has motivated development of schemes to acquire appropriate amounts of each data type in a single survey and to produce an earth image through joint inversion. In particular, consideration is given to surveys where only sparse MT soundings are needed to drastically reduce the non-uniqueness associated with background uncertainty while straining logistics minimally. Synthetic and field data are analysed using 2D and 3D finite element platforms developed for this purpose. Results to date suggest that indeed dense ZTEM surveys can provide detailed heterogeneous model images with large-scale averages constrained by a modest number of MT soundings. Further research is needed in determining the allowable degree of MT sparseness and the

  17. RESPONSIBLE OWNERSHIP OF DOGS AND CATS FROM SINOP-MT: DESCRIPTIVE STUDY

    Directory of Open Access Journals (Sweden)

    C. B. De Carli

    2015-02-01

    Full Text Available This research aimed to raise information on the relationship among owners from Sinop/MT and their pets, and also to diagnose the practice of responsible ownership. For this purpose, we developed a questionnaire, which was applied to 77 dog’s and cat’s owners, attended at the Veterinary Hospital of the Federal University of Mato Grosso – Sinop, MT. The obtained results showed the majority of the owners miss information and knowledge about how to take good care of their pets. Most of them foster animals for emotional reasons but, despite this, we can’t conclude they are able to practice responsible ownership.

  18. Experiment operations plan for the MT-4 experiment in the NRU reactor

    International Nuclear Information System (INIS)

    Russcher, G.E.; Wilson, C.L.; Parchen, L.J.; Marshall, R.K.; Hesson, G.M.; Webb, B.J.; Freshley, M.D.

    1983-06-01

    A series of thermal-hydraulic and cladding materials deformation experiments were conducted using light-water reactor fuel bundles as part of the Pacific Northwest Laboratory Loss-of-Coolant Accident (LOCA) Simulation Program. This report is the formal operations plan for MT-4 - the fourth materials deformation experiment conducted in the National Research Universal (NRU) reactor, Chalk River, Ontario, Canada. A major objective of MT-4 was to simulate a pressurized water reactor LOCA that could induce fuel rod cladding deformation and rupture due to a short-term adiabatic transient and a peak fuel cladding temperature of 1200K (1700 0 F)

  19. Evaluating the economic and noneconomic impacts of the veterinary medical profession in Michigan.

    Science.gov (United States)

    Lloyd, J W; Dartt, B A

    2000-01-01

    This study reaffirms the diversity and breadth of the veterinary profession. As it turns out, some of the furthest-reaching impacts of the veterinary medical profession were largely non-quantifiable. The veterinary medical profession had a substantial direct economic impact in Michigan during 1995. The total economic contribution of the veterinary medical profession to Michigan during 1995 that was attributable to expenditures on salaries, supplies, services, and their multiplier effect was approximately $500 million. In addition, the profession was associated with nearly 8,500 jobs (combined professional and lay positions). The veterinary medical profession was also considered to have an impact on the prosperity of the live-stock, equine, and pet food industries in Michigan, even though the economic contribution in these areas could not be directly quantified. Economic well-being of the individual businesses in these industries is directly related to the health and productivity of the associated animals, and improvements in output or productivity that accompany improved animal health likely carry substantial economic benefits in these sectors. In addition, progressive animal health management provides a crucial method of managing risk in the animal industries. Similarly, although the economic contribution could not be quantified, the veterinary medical profession enhances the safety and quality of human food through research, regulation, and quality assurance programs in livestock production, minimizing the risk of drug residues and microbial contamination. During 1995, approximately 5.3 million Michigan residents benefitted from the physical, psychological, and emotional well-being that accompanies companion animal ownership. By preserving the health and longevity of companion animals, veterinarians sustain and enhance these aspects of the human-animal bond. As Michigan enters a new century, it is likely that the state's veterinary medical profession will

  20. ADVANCED CHARACTERIZATION OF FRACTURED RESERVOIRS IN CARBONATE ROCKS: THE MICHIGAN BASIN

    Energy Technology Data Exchange (ETDEWEB)

    James R. Wood; William B. Harrison

    2002-12-01

    The purpose of the study was to collect and analyze existing data on the Michigan Basin for fracture patterns on scales ranging form thin section to basin. The data acquisition phase has been successfully concluded with the compilation of several large digital databases containing nearly all the existing information on formation tops, lithology and hydrocarbon production over the entire Michigan Basin. These databases represent the cumulative result of over 80 years of drilling and exploration. Plotting and examination of these data show that contrary to most depictions, the Michigan Basin is in fact extensively faulted and fractured, particularly in the central portion of the basin. This is in contrast to most of the existing work on the Michigan Basin, which tends to show relatively simple structure with few or minor faults. It also appears that these fractures and faults control the Paleozoic sediment deposition, the subsequent hydrocarbon traps and very likely the regional dolomitization patterns. Recent work has revealed that a detailed fracture pattern exists in the interior of the Central Michigan Basin, which is related to the mid-continent gravity high. The inference is that early Precambrian, ({approx}1 Ga) rifting events presumed by many to account for the gravity anomaly subsequently controlled Paleozoic sedimentation and later hydrocarbon accumulation. There is a systematic relationship between the faults and a number of gas and oil reservoirs: major hydrocarbon accumulations consistently occur in small anticlines on the upthrown side of the faults. The main tools used in this study to map the fault/fracture patterns are detailed, close-interval (CI = 10 feet) contouring of the formation top picks accompanied by a new way of visualizing the data using a special color spectrum to bring out the third dimension. In addition, recent improvements in visualization and contouring software were instrumental in the study. Dolomitization is common in the

  1. A GIS-Enabled, Michigan-Specific, Hierarchical Groundwater Modeling and Visualization System

    Science.gov (United States)

    Liu, Q.; Li, S.; Mandle, R.; Simard, A.; Fisher, B.; Brown, E.; Ross, S.

    2005-12-01

    Efficient management of groundwater resources relies on a comprehensive database that represents the characteristics of the natural groundwater system as well as analysis and modeling tools to describe the impacts of decision alternatives. Many agencies in Michigan have spent several years compiling expensive and comprehensive surface water and groundwater inventories and other related spatial data that describe their respective areas of responsibility. However, most often this wealth of descriptive data has only been utilized for basic mapping purposes. The benefits from analyzing these data, using GIS analysis functions or externally developed analysis models or programs, has yet to be systematically realized. In this talk, we present a comprehensive software environment that allows Michigan groundwater resources managers and frontline professionals to make more effective use of the available data and improve their ability to manage and protect groundwater resources, address potential conflicts, design cleanup schemes, and prioritize investigation activities. In particular, we take advantage of the Interactive Ground Water (IGW) modeling system and convert it to a customized software environment specifically for analyzing, modeling, and visualizing the Michigan statewide groundwater database. The resulting Michigan IGW modeling system (IGW-M) is completely window-based, fully interactive, and seamlessly integrated with a GIS mapping engine. The system operates in real-time (on the fly) providing dynamic, hierarchical mapping, modeling, spatial analysis, and visualization. Specifically, IGW-M allows water resources and environmental professionals in Michigan to: * Access and utilize the extensive data from the statewide groundwater database, interactively manipulate GIS objects, and display and query the associated data and attributes; * Analyze and model the statewide groundwater database, interactively convert GIS objects into numerical model features

  2. Hydrologic environment of the Silurian salt deposits in parts of Michigan, Ohio, and New York

    Science.gov (United States)

    Norris, Stanley E.

    1978-01-01

    The aggregate thickness of evaporites (salt, gypsum, and anhydrite) in the Silurian Salina sequence in Michigan exceeds 1200 feet in areas near the periphery of the Michigan basin, where the salt beds are less than 3000 feet below land surface. In northeast Ohio the aggregate thickness of salt beds is as much as 200 feet in places, and in western New York it is more than 500 feet, where th beds are less than 3000 feet deep. The salt-bearing rocks dip regionally on the order of 50 feet per mile; those in Michigan dip toward the center of the Michigan basin, and those in Ohio and New York, in the Appalachian basin, dip generally southward. The rocks in both basins thicken downdip. Minor folds and faults occur in the salt-bearing rocks in all three states. Some of this defrmation has been attenuated or absorbed bo the salt beds. Occuring near the middle of thick sedimentary sequences, the salt beds are bounded aboe and below by beds containing water having dissolved-solids concentrations several times that seawter. The brines occur commonly in discrete zones of high permeability at specific places in the stratigraphic sequence. In northeast Ohio two prominent brine zones are recognized by the driller, the Devonian Oriskany Sandstone, or 'first water' zone, above the Salina Formation, and the Newburg or 'second water' zone below the Salina. In each aquifer there is a vertical component of hydraulic head, but little brine probably moves through the salt beds because their permeability is extremely low. Also, ther is little evidence of dissolution of the salt in areas distant from the outcrop, suggesting that if brine does move through the salt, movement is at a slow enough rate so that, in combination with the saturated or near-saturated condition of the water, it precludes significant dissolution. Principal brine movement is probably in the permeable zones in the direction of the hydraulic gradient. Two areas in Michigan and one area each in Ohio and New York appear

  3. Long-Term Groundwater Monitoring Optimization, Clare Water Supply Superfund Site, Permeable Reactive Barrier and Soil Remedy Areas, Clare, Michigan

    Science.gov (United States)

    This report contains a review of the long-term groundwater monitoring network for the Permeable Reactive Barrier (PRB) and Soil Remedy Areas at the Clare Water Supply Superfund Site in Clare, Michigan.

  4. Evaluating the financial cost and impact on long-term pavement performance of expediting Michigan's road construction work.

    Science.gov (United States)

    2014-02-01

    The Michigan Department of Transportation (MDOT) has been using monetary incentive payments for many : years to accelerate highway construction work, resulting in reduced delays to the traveling public. It was : envisioned that incentive/disincentive...

  5. A mercury transport and fate model (LM2-mercury) for mass budget assessment of mercury cycling in Lake Michigan

    Science.gov (United States)

    LM2-Mercury, a mercury mass balance model, was developed to simulate and evaluate the transport, fate, and biogeochemical transformations of mercury in Lake Michigan. The model simulates total suspended solids (TSS), disolved organic carbon (DOC), and total, elemental, divalent, ...

  6. Perceptual learning of motion direction discrimination with suppressed and unsuppressed MT in humans: an fMRI study.

    Directory of Open Access Journals (Sweden)

    Benjamin Thompson

    Full Text Available The middle temporal area of the extrastriate visual cortex (area MT is integral to motion perception and is thought to play a key role in the perceptual learning of motion tasks. We have previously found, however, that perceptual learning of a motion discrimination task is possible even when the training stimulus contains locally balanced, motion opponent signals that putatively suppress the response of MT. Assuming at least partial suppression of MT, possible explanations for this learning are that 1 training made MT more responsive by reducing motion opponency, 2 MT remained suppressed and alternative visual areas such as V1 enabled learning and/or 3 suppression of MT increased with training, possibly to reduce noise. Here we used fMRI to test these possibilities. We first confirmed that the motion opponent stimulus did indeed suppress the BOLD response within hMT+ compared to an almost identical stimulus without locally balanced motion signals. We then trained participants on motion opponent or non-opponent stimuli. Training with the motion opponent stimulus reduced the BOLD response within hMT+ and greater reductions in BOLD response were correlated with greater amounts of learning. The opposite relationship between BOLD and behaviour was found at V1 for the group trained on the motion-opponent stimulus and at both V1 and hMT+ for the group trained on the non-opponent motion stimulus. As the average response of many cells within MT to motion opponent stimuli is the same as their response to non-directional flickering noise, the reduced activation of hMT+ after training may reflect noise reduction.

  7. A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1-MMP

    DEFF Research Database (Denmark)

    Shiryaev, S A; Remacle, A G; Golubkov, V S

    2013-01-01

    Matrix metalloproteinases (MMPs) and, especially membrane type 1 (MT1)-MMP/MMP-14, are promising drug targets in malignancies. In contrast with multiple small-molecule and protein pan-inhibitors of MT1-MMP cleavage activity, the murine 9E8 monoclonal antibody targets the MMP-2-activating function...... of cellular MT1-MMP alone, rather than the general proteolytic activity and the pro-migratory function of MT1-MMP. Furthermore, the antibody does not interact in any detectable manner with other members of the membrane type (MT)-MMP family. The mechanism of this selectivity remained unknown. Using mutagenesis......, binding and activity assays, and modeling in silico, we have demonstrated that the 9E8 antibody recognizes the MT-loop structure, an eight residue insertion that is specific for MT-MMPs and that is distant from the MT1-MMP active site. The binding of the 9E8 antibody to the MT-loop, however, prevents...

  8. The food of the lake trout (Cristivomer namaycush namaycush) and of the lawyer (Lota maculosa) of Lake Michigan

    Science.gov (United States)

    Van Oosten, John; Deason, Hilary J.

    1938-01-01

    This paper reports on a qualitative and quantitative analysis of the contents of 4,979 lake trout stomachs (593 examined in 1930 and 1,253 collected in 1931 from southern Lake Michigan, 1,446 from northern Lake Michigan and 1,687 from Green Bay in 1932), and of a total of 1,528 lawyer stomachs (172 examined in 1930 and 734 collected in 1931 from southern Lake Michigan, 612 from northern Lake Michigan and 10 from Green Bay in 1932). The food of the trout consisted of 98 per cent by volume of fish of which Cottidae and Coregonidae were the principal constituents. Cottidae were dominant in southern Lake Michigan (72 per cent by volume), Coregonidae in northern Lake Michigan (51 per cent) but the lake shiner, Notropis atherinides, was most important in Green Bay in the spring of the year (64 per cent). The lawyer food consisted of 74 per cent by volume of fish and 26 per cent invertebrates. Dominant items were Cottidae (76 per cent by volume) in southern Lake Michigan, Coregonidae (51 per cent) and Pontoporeia (37 per cent) in northern Lake Michigan, and Percopsis (34 per cent) and Mysis (26 per cent) in Green Bay. Data are also presented on the frequency of occurrence (number of stomachs) of the food items and its variation with the sizes of the trout and lawyers, depths of water, seasons, and localities; on the number of individual fish of each species destroyed by the trout and lawyers; and on the calculated volume of the food fishes preceding digestion. The lake trout and lawyer are competitors for the same food, are both predators of the commercially important Coregonidae, and the lawyer through its consumption of invertebrates is a food competitor of the Coregonidae.

  9. 77 FR 21439 - Safety Zones; Annual Events Requiring Safety Zones in the Captain of the Port Lake Michigan Zone

    Science.gov (United States)

    2012-04-10

    ... Memorial Drive, Milwaukee, WI 53207, between 8 a.m. and 3 p.m., Monday through Friday, except Federal.... The Sunday before Memorial Day; 8:30 p.m. to 10 p.m. (6) Michigan Super Boat Grand Prix; Michigan City... time. The second Friday of June; 9 p.m. to 11 p.m. (9) Harborfest Music and Family Festival; Racine, WI...

  10. Monument of nature? An ethnography of the world heritage of Mt. Kenya

    NARCIS (Netherlands)

    Akker, van den M.L.

    2016-01-01

    This dissertation examines the World Heritage status of Mt. Kenya, an alpine area in Central Kenya. The mountain joined the World Heritage List in 1997 and in 2013 the original designation expanded to cover a larger area. Both events were formulated exclusively in natural scientific language. This

  11. 76 FR 28065 - Notice of Intent To Repatriate a Cultural Item: Montana Historical Society, Helena, MT

    Science.gov (United States)

    2011-05-13

    ... Montana Historical Society, Helena, MT, that meets the definition of a sacred object under 25 U.S.C. 3001... donated it to the Society's collections in 1900. Consultation with Blackfeet tribal and religious leaders... religious society, and it is required for the practice of a traditional religion by contemporary adherents...

  12. Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

    Science.gov (United States)

    Safdar, Adeel; Bourgeois, Jacqueline M.; Ogborn, Daniel I.; Little, Jonathan P.; Hettinga, Bart P.; Akhtar, Mahmood; Thompson, James E.; Melov, Simon; Mocellin, Nicholas J.; Kujoth, Gregory C.; Prolla, Tomas A.; Tarnopolsky, Mark A.

    2011-01-01

    A causal role for mitochondrial DNA (mtDNA) mutagenesis in mammalian aging is supported by recent studies demonstrating that the mtDNA mutator mouse, harboring a defect in the proofreading-exonuclease activity of mitochondrial polymerase gamma, exhibits accelerated aging phenotypes characteristic of human aging, systemic mitochondrial dysfunction, multisystem pathology, and reduced lifespan. Epidemiologic studies in humans have demonstrated that endurance training reduces the risk of chronic diseases and extends life expectancy. Whether endurance exercise can attenuate the cumulative systemic decline observed in aging remains elusive. Here we show that 5 mo of endurance exercise induced systemic mitochondrial biogenesis, prevented mtDNA depletion and mutations, increased mitochondrial oxidative capacity and respiratory chain assembly, restored mitochondrial morphology, and blunted pathological levels of apoptosis in multiple tissues of mtDNA mutator mice. These adaptations conferred complete phenotypic protection, reduced multisystem pathology, and prevented premature mortality in these mice. The systemic mitochondrial rejuvenation through endurance exercise promises to be an effective therapeutic approach to mitigating mitochondrial dysfunction in aging and related comorbidities. PMID:21368114

  13. Allozyme and mtDNA variation of white seabream Diplodus sargus ...

    African Journals Online (AJOL)

    These results can be explained by the chaotic genetic patchiness hypothesis. In contrast, the mtDNA data indicated genetic homogeneity among localities showing the absence of structure in white seabream populations across the Siculo-Tunisian Strait. Historical demography of this species suggests that it has undergone ...

  14. Regulation of MT1-MMP/MMP-2/TIMP-2 axis in human placenta

    Directory of Open Access Journals (Sweden)

    Vincent ZL

    2015-10-01

    Full Text Available Zoë L Vincent,1,2 Murray D Mitchell,l,3 Anna P Ponnampalam1,2 1Liggins Institute, 2Gravida: National Centre for Growth and Development, University of Auckland, Auckland, New Zealand; 3University of Queensland Centre for Clinical Research, Brisbane, QLD, Australia Abstract: Matrix metalloproteinases (MMPs and specific endogenous tissue inhibitors of metalloproteinases (TIMPs mediate rupture of the fetal membranes in both physiological and pathological conditions. MMPs and TIMPs are subject to regulation by DNA methylation in human malignancies and pre-eclampsia. To determine if membrane type 1 MMP (MT1-MMP, MMP2, and TIMP2 are regulated by DNA methylation in human placentas, we employed an in vitro model where human placental tissues were collected at term gestation and cultured with methylation inhibiting agent 5-aza-2′deoxycytidine (AZA and lipopolysaccharide. The results suggest that DNA methylation is not directly involved in the regulation of MT1-MMP in placental tissue; however, remodeling of chromatin by a pharmacologic agent such as AZA potentiates an infection-related increase in MT1-MMP. MT1-MMP is a powerful activator of MMP2 and this action, coupled with either no change or a decrease in TIMP2 concentrations, favors a gelatinolytic state leading to extracellular matrix degradation, which could predispose fetal membranes to rupture prematurely during inflammation. Keywords: placenta, epigenetic regulation, DNA methylation, MMPs, labor

  15. Amide Proton Transfer (APT) MR imaging and Magnetization Transfer (MT) MR imaging of pediatric brain development

    International Nuclear Information System (INIS)

    Zhang, Hong; Kang, Huiying; Peng, Yun; Zhao, Xuna; Jiang, Shanshan; Zhang, Yi; Zhou, Jinyuan

    2016-01-01

    To quantify the brain maturation process during childhood using combined amide proton transfer (APT) and conventional magnetization transfer (MT) imaging at 3 Tesla. Eighty-two neurodevelopmentally normal children (44 males and 38 females; age range, 2-190 months) were imaged using an APT/MT imaging protocol with multiple saturation frequency offsets. The APT-weighted (APTW) and MT ratio (MTR) signals were quantitatively analyzed in multiple brain areas. Age-related changes in MTR and APTW were evaluated with a non-linear regression analysis. The APTW signals followed a decreasing exponential curve with age in all brain regions measured (R"2 = 0.7-0.8 for the corpus callosum, frontal and occipital white matter, and centrum semiovale). The most significant changes appeared within the first year. At maturation, larger decreases in APTW and lower APTW values were found in the white matter. On the contrary, the MTR signals followed an increasing exponential curve with age in the same brain regions measured, with the most significant changes appearing within the initial 2 years. There was an inverse correlation between the MTR and APTW signal intensities during brain maturation. Together with MT imaging, protein-based APT imaging can provide additional information in assessing brain myelination in the paediatric population. (orig.)

  16. Characterization of mtDNA haplogroups in 14 Mexican indigenous populations.

    Science.gov (United States)

    Peñaloza-Espinosa, Rosenda I; Arenas-Aranda, Diego; Cerda-Flores, Ricardo M; Buentello-Malo, Leonor; González-Valencia, Gerardo; Torres, Javier; Alvarez, Berenice; Mendoza, Irma; Flores, Mario; Sandoval, Lucila; Loeza, Francisco; Ramos, Irma; Muñoz, Leopoldo; Salamanca, Fabio

    2007-06-01

    In this descriptive study we investigated the genetic structure of 513 Mexican indigenous subjects grouped in 14 populations (Mixteca-Alta, Mixteca-Baja, Otomi, Purépecha, Tzeltal, Tarahumara, Huichol, Nahua-Atocpan, Nahua-Xochimilco, Nahua-Zitlala, Nahua-Chilacachapa, Nahua-Ixhuatlancillo, Nahua-Necoxtla, and Nahua-Coyolillo) based on mtDNA haplogroups. These communities are geographically and culturally isolated; parents and grandparents were born in the community. Our data show that 98.6% of the mtDNA was distributed in haplogroups A1, A2, B1, B2, C1, C2, D1, and D2. Haplotype X6 was present in the Tarahumara (1/53) and Huichol (3/15), and haplotype L was present in the Nahua-Coyolillo (3/38). The first two principal components accounted for 95.9% of the total variation in the sample. The mtDNA haplogroup frequencies in the Purépecha and Zitlala were intermediate to cluster 1 (Otomi, Nahua-Ixhuatlancillo, Nahua-Xochimilco, Mixteca-Baja, and Tzeltal) and cluster 2 (Nahua-Necoxtla, Nahua-Atocpan, and Nahua-Chilacachapa). The Huichol, Tarahumara, Mixteca-Alta, and Nahua-Coyolillo were separated from the rest of the populations. According to these findings, the distribution of mtDNA haplogroups found in Mexican indigenous groups is similar to other Amerindian haplogroups, except for the African haplogroup found in one population.

  17. 75 FR 54381 - Charles M. Russell National Wildlife Refuge and UL Bend National Wildlife Refuge, MT

    Science.gov (United States)

    2010-09-07

    ... DEPARTMENT OF THE INTERIOR Fish and Wildlife Service [FWS-R6-R-2010-N078; 60138-1261-6CCP-S3] Charles M. Russell National Wildlife Refuge and UL Bend National Wildlife Refuge, MT AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of availability: Draft comprehensive conservation plan and draft...

  18. Pleistocene-Holocene boundary in Southern Arabia from the perspective of human mtDNA variation

    Czech Academy of Sciences Publication Activity Database

    Al-Abri, A.-R.; Podgorná, E.; Rose, J. I.; Pereira, L.; Mulligan, C. J.; Silva, N. M.; Bayoumi, R.; Soares, P.; Černý, Viktor

    2012-01-01

    Roč. 149, č. 2 (2012), s. 291-298 ISSN 0002-9483 R&D Projects: GA MŠk ME 917 Institutional research plan: CEZ:AV0Z80020508 Keywords : mtDNA variation * Arabian Peninsula * migrations Subject RIV: AC - Archeology, Anthropology, Ethnology Impact factor: 2.481, year: 2012

  19. Mutations of mtDNA polymerase-γ and hyperlactataemia in the HIV ...

    African Journals Online (AJOL)

    Mutations of mtDNA polymerase-γ and hyperlactataemia in the HIV-infected Zulu population of South Africa. ... D B A Ojwach, C Aldous, P Kocheleff, B Sartorius ... of their capacity to impede human mitochondrial DNA polymerase-γ (POLG), ...

  20. Comprehensive view of the population history of Arabia as inferred by mtDNA variation

    Czech Academy of Sciences Publication Activity Database

    Černý, Viktor; Čížková, M.; Poloni, E. S.; Al-Meeri, A.; Mulligan, C. J.

    2016-01-01

    Roč. 159, č. 4 (2016), s. 607-616 ISSN 0002-9483 R&D Projects: GA ČR GA13-37998S Institutional support: RVO:67985912 Keywords : mtDNA variation * Arabian Peninsula * migrations Subject RIV: AC - Archeology, Anthropology, Ethnology Impact factor: 2.552, year: 2016