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Sample records for mpd

  1. Mouse Phenome Database (MPD)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Mouse Phenome Database (MPD) has characterizations of hundreds of strains of laboratory mice to facilitate translational discoveries and to assist in selection...

  2. MPD thruster research issues, activities, strategies

    Science.gov (United States)

    1991-01-01

    The following activities and plans in the MPD thruster development are summarized: (1) experimental and theoretical research (magnetic nozzles at present and high power levels, MPD thrusters with applied fields extending into the thrust chamber, and improved electrode performance); and (2) tools (MACH2 code for MPD and nozzle flow calculation, laser diagnostics and spectroscopy for non-intrusive measurements of flow conditions, and extension to higher power). National strategies are also outlined.

  3. MPD model for radar echo signal of hypersonic targets

    Directory of Open Access Journals (Sweden)

    Xu Xuefei

    2014-08-01

    Full Text Available The stop-and-go (SAG model is typically used for echo signal received by the radar using linear frequency modulation pulse compression. In this study, the authors demonstrate that this model is not applicable to hypersonic targets. Instead of SAG model, they present a more realistic echo signal model (moving-in-pulse duration (MPD for hypersonic targets. Following that, they evaluate the performances of pulse compression under the SAG and MPD models by theoretical analysis and simulations. They found that the pulse compression gain has an increase of 3 dB by using the MPD model compared with the SAG model in typical cases.

  4. Optimized Magnetic Nozzles for MPD Thrusters, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Magnetoplasmadynamic (MPD) thrusters can provide the high-specific impulse, high-power propulsion required to enable ambitious human and robotic exploration missions...

  5. Projective geometry for the NICA/MPD Electromagnetic Calorimeter

    Science.gov (United States)

    Basylev, S.; Dabrowska, B.; Egorov, D.; Filippov, I.; Golovatyuk, V.; Krechetov, Yu.; Shutov, A.; Shutov, V.; Terletskiy, A.; Tyapkin, I.

    2018-02-01

    A Multi Purpose Detector (MPD) is being constructed for the Heavy-Ion Collider at Dubna (NICA). One of the important components of MPD setup is an Electromagnetic Calorimeter, which will operate in the magnetic field of MPD solenoid 0.5 T and provide good energy and space resolution to detect particles in the energy range from ~20 MeV to few GeV . For this purpose the, so-called, "shashlyk" sampling structure with the fiber readout to the silicon Multi Pixel Avalanche Photodetector is used. Serious modifications in comparison to conventional "shaslyk" calorimeter are proposed to improve the properties of device. These modifications are presented in the report along with the beam test results obtained with the MPD/NICA module prototypes.

  6. MPD3: a useful medicinal plants database for drug designing.

    Science.gov (United States)

    Mumtaz, Arooj; Ashfaq, Usman Ali; Ul Qamar, Muhammad Tahir; Anwar, Farooq; Gulzar, Faisal; Ali, Muhammad Amjad; Saari, Nazamid; Pervez, Muhammad Tariq

    2017-06-01

    Medicinal plants are the main natural pools for the discovery and development of new drugs. In the modern era of computer-aided drug designing (CADD), there is need of prompt efforts to design and construct useful database management system that allows proper data storage, retrieval and management with user-friendly interface. An inclusive database having information about classification, activity and ready-to-dock library of medicinal plant's phytochemicals is therefore required to assist the researchers in the field of CADD. The present work was designed to merge activities of phytochemicals from medicinal plants, their targets and literature references into a single comprehensive database named as Medicinal Plants Database for Drug Designing (MPD3). The newly designed online and downloadable MPD3 contains information about more than 5000 phytochemicals from around 1000 medicinal plants with 80 different activities, more than 900 literature references and 200 plus targets. The designed database is deemed to be very useful for the researchers who are engaged in medicinal plants research, CADD and drug discovery/development with ease of operation and increased efficiency. The designed MPD3 is a comprehensive database which provides most of the information related to the medicinal plants at a single platform. MPD3 is freely available at: http://bioinform.info .

  7. Evaporative behavior of carbon with MPD Arc Jet

    Energy Technology Data Exchange (ETDEWEB)

    Sukegawa, Toshio; Madarame, Haruki; Okamoto, Koji [Tokyo Univ., Tokai, Ibaraki (Japan). Nuclear Engineering Research Lab.

    1996-10-01

    Using the Magneto-Plasma-Dynamic Arc Jet (MPD Arc Jet) device, the plasma-material interaction during simulated plasma disruption was experimentally investigated. To clarify the effects of the evaporation, the isotropic graphite was used as a target. The thermal conductivity of the isotropic graphite was much higher than that of the pyrolytic graphite, resulting in smaller evaporation. The light intensity distribution during the simulated disruption for the isotropic graphite was quite different from that for the pyrolytic graphite. (author)

  8. Feasibility of flow studies at NICA/MPD

    Energy Technology Data Exchange (ETDEWEB)

    Geraksiev, N. S., E-mail: nikolay.geraksiev@gmail.com [Plovdiv University “Paisii Hilendarski”, FPET (Bulgaria); Collaboration: MPD Collaboration

    2015-12-15

    In the light of recent developments in heavy ion physic, anisotropic flow measurements play a key role in a better understanding of the hot and dense barionic matter. In the presented article a short introduction to the proposed NICA/MPD project is given, as well as a brief description of the event-plane method used to estimate the elliptic flow of reconstructed and identified hadrons (p, π, Λ)

  9. The Multi-Purpose Detector (MPD) of the collider experiment

    Energy Technology Data Exchange (ETDEWEB)

    Golovatyuk, V.; Kekelidze, V.; Kolesnikov, V.; Rogachevsky, O. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Sorin, A. [Joint Institute for Nuclear Research, Dubna (Russian Federation); National Research Nuclear University (MEPhI), Moscow (Russian Federation)

    2016-08-15

    The project NICA (Nuclotron-based Ion Collider fAcility) is aimed to study dense baryonic matter in heavy-ion collisions in the energy range up to √(s{sub NN}) = 11 GeV with average luminosity of L = 10{sup 27} cm{sup -2}s{sup -1} (for {sup 197}Au{sup 79}). The experimental program at the NICA collider will be performed with the Multi-Purpose Detector (MPD). We report on the main physics objectives of the NICA heavy-ion program and present the main detector components. (orig.)

  10. Recent developments in track reconstruction and hadron identification at MPD

    Science.gov (United States)

    Mudrokh, A.; Zinchenko, A.

    2017-03-01

    A Monte Carlo simulation of real detector effects with as many details as possible has been carried out instead of a simplified Geant point smearing approach during the study of the detector performance. Some results of realistic simulation of the MPD TPC (Time Projection Chamber) including digitization in central Au+Au collisions have been obtained. Particle identification (PID) has been tuned to account for modifications in the track reconstruction. Some results on hadron identification in the TPC and TOF (Time Of Flight) detectors with realistically simulated response have been also obtained.

  11. Application of precise MPD & pressure balance cementing technology

    Directory of Open Access Journals (Sweden)

    Yong Ma

    2018-03-01

    Full Text Available The precise managed pressure drilling (MPD technology is mainly used to deal with the difficulties encountered when oil and gas open hole sections with multiple pressure systems and the strata with narrow safety density window are drilled through. If its liner cementing is carried out according to the conventional method, lost circulation is inevitable in the process of cementing while the displacement efficiency of small-clearance liner cementing is satisfied. If the positive and inverse injection technology is adopted, the cementing quality cannot meet the requirements of later well test engineering of ultradeep wells. In this paper, the cementing operation of Ø114.3 mm liner in Well Longgang 70 which was drilled in the Jiange structure of the Sichuan Basin was taken as an example to explore the application of the cementing technology based on the precise MPD and pressure balancing method to the cementing of long open-hole sections (as long as 859 m with both high and low pressures running through multiple reservoirs. On the one hand, the technical measures were taken specifically to ensure the annulus filling efficiency of slurry and the pressure balance in the whole process of cementing. And on the other hand, the annulus pressure balance was precisely controlled by virtue of precise MPD devices and by injecting heavy weight drilling fluids through central pipes, and thus the wellbore pressure was kept steady in the whole process of cementing in the strata with narrow safety density window. It is indicated that Ø114.3 mm liner cementing in this well is good with qualified pressure tests and no channeling emerges at a funnel during the staged density reduction. It is concluded that this method can enhance the liner cementing quality of complex ultradeep gas wells and improve the wellbore conditions for the later safe well tests of high-pressure gas wells. Keywords: Ultradeep well, Liner cementing, Narrow safety density window, Precise

  12. BM@N and MPD experiments at NICA

    Directory of Open Access Journals (Sweden)

    Kekelidze Vladimir

    2018-01-01

    Full Text Available The project NICA (Nuclotron-based Ion Collider fAcility aims to study hot and baryon rich QCD matter in heavy ion collisions in the energy range SNN = 4 − 11 GeV. The rich heavy-ion physics program will be performed at two experiments, BM@N (Baryonic Matter at Nuclotron at beams extracted from the Nuclotron, and at MPD (Multi-Purpose Detector at the NICA collider. This program covers a variety of phenomena in strongly interacting matter of the highest baryonic density, which includes study of collective effects, production of hyperon and hypernuclei, in-medium modification of meson properties, and event-by-event fluctuations.

  13. High Power MPD Thruster Development at the NASA Glenn Research Center

    Science.gov (United States)

    LaPointe, Michael R.; Mikellides, Pavlos G.; Reddy, Dhanireddy (Technical Monitor)

    2001-01-01

    Propulsion requirements for large platform orbit raising, cargo and piloted planetary missions, and robotic deep space exploration have rekindled interest in the development and deployment of high power electromagnetic thrusters. Magnetoplasmadynamic (MPD) thrusters can effectively process megawatts of power over a broad range of specific impulse values to meet these diverse in-space propulsion requirements. As NASA's lead center for electric propulsion, the Glenn Research Center has established an MW-class pulsed thruster test facility and is refurbishing a high-power steady-state facility to design, build, and test efficient gas-fed MPD thrusters. A complimentary numerical modeling effort based on the robust MACH2 code provides a well-balanced program of numerical analysis and experimental validation leading to improved high power MPD thruster performance. This paper reviews the current and planned experimental facilities and numerical modeling capabilities at the Glenn Research Center and outlines program plans for the development of new, efficient high power MPD thrusters.

  14. Readout system of TPC/MPD NICA project

    Energy Technology Data Exchange (ETDEWEB)

    Averyanov, A. V.; Bajajin, A. G.; Chepurnov, V. F.; Cheremukhina, G. A.; Fateev, O. V.; Korotkova, A. M.; Levchanovskiy, F. V.; Lukstins, J.; Movchan, S. A.; Razin, S. V.; Rybakov, A. A.; Vereschagin, S. V., E-mail: vereschagin@jinr.ru; Zanevsky, Yu. V.; Zaporozhets, S. A.; Zruyev, V. N. [Joint Institute for Nuclear Research (Russian Federation)

    2015-12-15

    The time-projection chamber (TPC) is the main tracking detector in the MPD/NICA. The information on charge-particle tracks in the TPC is registered by the MWPG with cathode pad readout. The frontend electronics (FEE) are developed with use of modern technologies such as application specific integrated circuits (ASIC), field-programmable gate arrays (FPGA), and data transfer to a concentrator via a fast optical interface. The main parameters of the FEE are as follows: total number of channels, ∼95 000; data stream from the whole TPC, 5 GB/s; low power consumption, less than 100 mW/ch; signal to noise ratio (S/N), 30; equivalent noise charge (ENC), <1000e{sup –} (C{sub in} = 10–20 pF); and zero suppression (pad signal rejection ∼90%). The article presents the status of the readout chamber construction and the data acquisition system. The results of testing FEE prototypes are presented.

  15. Density and velocity measurements of a sheath plasma from MPD thruster

    Energy Technology Data Exchange (ETDEWEB)

    Ko, J.J.; Cho, T.S.; Choi, M.C.; Choi, E.H.; Cho, G.S.; Uhm, H.S.

    1999-07-01

    Magnetoplasma is the plasma that the electron and ion orbits are strongly confined by intense magnetic field. Recently, magnetoplasma dynamics (MPD) has been investigated in connection with applications to the rocket thruster in USA, Germany, etc. It can be widely applicable, including modification of satellite position and propulsion of the interplanetary space shuttle. A travel for a long distance journey is possible because a little amount of neutral gases is needed for the plasma source. Besides, this will provide a pollution free engine for future generations. MPD thruster is not a chemical engine. The authors have built a Mather type MPD thruster, which has 1 kV max charging, 10 kA max current flows, and has about 1 ms characteristic operation time. The Paschen curve of this thruster is measured and its minimum breakdown voltage occurs in the pressure range of 0.1 to 1 Torr. Langmuir and double probes are fabricated to diagnose the sheath plasma from the thruster. The temperature and density are calculated to be 2.5 eV and 10{sup 15} cm {sup {minus}3}, respectively, from the probe data. Making use of photo diode, an optical probe is fabricated to measure propagation velocity of the sheath plasma. The sheath plasma from the MPD thruster in the experiment propagates with velocity of 1 cm/{micro}s.

  16. The first experiment of MPD Jet injection into GAMMA 10 plasma

    International Nuclear Information System (INIS)

    Ichimura, Kazuya; Nakashima, Yousuke; Takeda, Hisato

    2014-01-01

    Results of the first experiment of short pulse plasma injection by MPD (magneto plasma dynamic) Jet into GAMMA 10/PDX's longer pulse plasma are reported. In the experiment, a new method for plasma start-up without using plasma guns was applied. In this method, the main plasma of GAMMA 10/PDX was produced by ECRH (electron cyclotron resonance heating) and ICRF (ion cyclotron range of frequency). Then, MPD Jet plasma was injected into the main plasma along magnetic field line. As a result, density of the main plasma was increased and the end-loss flux was doubled. Flow velocity of the plasmoid injected by the MPD Jet was evaluated from the change of plasma density in each cell of the tandem mirror. The result indicated that the flow speed is several km/s. It is found that the plasmoid worked as strong fueling device which dramatically raises the density of plasma. Therefore injection of MPD Jet plasma into tandem mirror can be a useful tool to study physical phenomena of divertor and PWI. (author)

  17. MEXnICA, Mexican group in the MPD-NICA experiment at JINR

    Science.gov (United States)

    Rodríguez Cahuantzi, M.; MEXnICA Group

    2017-10-01

    The Nuclotron Ion Collider fAcility (NICA) accelerator complex is currently under construction at the Joint Institute for Nuclear Research (JINR) laboratory located in the city of Dubna in the Russian Federation. The main goal of NICA is to collide heavy ion nuclei to study the properties of the phase diagram of strongly interacting matter at high baryon density. In this accelerator complex, two big particle detectors are planned to be installed: Spin Physics Detector (SPD) and Multi-Purpose Detector (MPD). At the design luminosity, the event rate in the MPD interaction region is about 6 kHz; the total charged particle multiplicity would exceeds 1000 in the most central Au+Au collisions at \\sqrt{{sNN}} = 11 {{GeV}}. Since the middle of 2016 a group of researchers and students from Mexican institutions was formed (MEXnICA). The main goal of the MEXnICA group is to collaborate in the experimental efforts of MPD-NICA proposing a BEam-BEam counter detector which we called BEBE. In this written general aspects of MPD-NICA detector and BEBE are discussed. This material was shown in a contributed talk given at the XXXI Annual Meeting of the Mexican Division of Particles and Fields held in the Physics Department of CINVESTAV located in Mexico City during the last week of May 2017.

  18. Measurements of plasma rotation in an axially magnetized MPD arc-jet

    Energy Technology Data Exchange (ETDEWEB)

    Tobari, Hiroyuki; Ashino, Masashi; Yoshino, Kyohei; Sagi, Yukiko; Yoshinuma, Mikirou; Hattori, Kunihiko; Ando, Akira; Inutake, Masaaki [Department of Electrical Engineering, Graduate School of Engineering, Tohoku University, Sendai, Miyagi (Japan)

    2001-01-24

    Characteristics of an axially magnetized MPD (magneto-plasma-dynamic) arcjet plasma are investigated by spectroscopy on the HITOP (High density of Tohoku Plasma) device in Tohoku University. Plasma flow and rotational velocity and temperature of He ion and atom near the muzzle region of MPD arcjet are measured by Doppler shift and broadening of the HeI ({lambda}=578.56 nm) and HeII ({lambda}=468.58 nm) lines. From the measured radial profile of rotational velocity and temperature of He ion, the radial profiles of electrical field and space potential are calculated and it has been found that the potential profile in the core region is parabolic, which shows the plasma rotates as a rigid body. (author)

  19. Mock Data Challenge for the MPD/NICA Experiment on the HybriLIT Cluster

    Science.gov (United States)

    Gertsenberger, Konstantin; Rogachevsky, Oleg

    2018-02-01

    Simulation of data processing before receiving first experimental data is an important issue in high-energy physics experiments. This article presents the current Event Data Model and the Mock Data Challenge for the MPD experiment at the NICA accelerator complex which uses ongoing simulation studies to exercise in a stress-testing the distributed computing infrastructure and experiment software in the full production environment from simulated data through the physical analysis.

  20. Helium-hydrogen microplasma device (MPD) on postage-stamp-size plastic-quartz chips.

    Science.gov (United States)

    Weagant, Scott; Karanassios, Vassili

    2009-10-01

    A new design of a miniaturized, atmospheric-pressure, low-power (e.g., battery-operated), self-igniting, planar-geometry microplasma device (MPD) for use with liquid microsamples is described. The inexpensive MPD was a hybrid, three-substrate quartz-plastic-plastic structure and it was formed on chips with area the size of a small postage stamp. The substrates were chosen for rapid prototyping and for speedy device-geometry testing and evaluation. The approximately 700-microm (diameter) and 7-mm (long) He-H(2) (3% H(2)) microplasma was formed by applying high-voltage ac between two needle electrodes. Operating conditions were found to be critical in sustaining stable microplasma on plastic substrates. Spectral interference from the electrode materials was not observed. A small-size, electrothermal vaporization system was used for introduction of microliter volumes of liquids into the MPD. The microplasma was operated from an inexpensive power supply. And, operation from a 14.4-V battery has been demonstrated. Microplasma background emission in the spectral range between 200 and 850 nm obtained using a portable, fiber-optic spectrometer is reported. Analyte emission from microliter volumes of dilute single-element standard solutions of Cd, Cu, K, Li, Mg, Mn, Na, Pb, and Zn is documented. Element-dependent precision was between 10-25% (the average was 15%) and detection limits ranged between 1.5 and 350 ng. The system was used for the determination of Na in diluted bottled-water samples.

  1. Evaluation of Electromagnetic Forces in an Axially-Magnetized MPD Arcjet Plasma

    International Nuclear Information System (INIS)

    Tobari, Hiroyuki; Yoshino, Kyohei; Hattori, Kunihiko; Ando, Akira; Inutake, Masaaki

    2003-01-01

    Characteristics of an axially-magnetized plasma flow has been investigated in the vicinity of a magneto-plasma-dynamic arcjet (MPDA) by use of spectroscopy, Mach probes and magnetic probes. Axial and rotational flow velocity and temperature of He ion and atom near the muzzle region of MPDA are measured by Doppler shift and broadening of the HeI (λ = 578.56 nm) and HeII (λ = 468.58 nm) lines. It has been observed that the plasma rotates with a rigid body and that ion temperature increases extraordinarily in a factor of 2-3 at several cm downstream from MPD outlet when a discharge current increases with a lower mass-flow-rate of He gas. Therefore, the ion acoustic Mach number saturates at near unity. To clarify mechanisms of ion heating and electromagnetic acceleration, spatial distribution of induced magnetic fields are measured in the vicinity of MPD outlet by magnetic probes. Spatial structure of magnetic field and plasma current density is clarified experimentally in the muzzle region of MPDA. Among three components of jxB force F, radial component Fr is dominant and axial component Fz is much smaller than Fr because of a generation of a drag force canceling an acceleration force

  2. Diagnostics of a stationary MPD-type plasma jet with a HCN laser interferometer

    International Nuclear Information System (INIS)

    Graser, W.; Hoffmann, P.

    1975-01-01

    A HCN laser interferometer of the Ashby-Jephcott type operating at a wavelength of 337 μm was used to measure spatially resolved electron densities in a stationary MPD-type plasma jet with non-LTE behavior. Experiments were performed with and without superimposed magnetic fields up to 0.1 T at the exit of the plasma accelerator. Electron densities were obtained within the limits of 5times10 12 and 10 15 cm -3 with an accuracy better than 10%. Within the axially symmetric expanding plasma of about 15-cm average diameter and 50-cm length the radial resolving power came to less than 1 cm. So this technique has proved to be suitable to fill a gap in the diagnostics of stationary magnetized plasmas in the mean range of electron densities. (auth)

  3. Is the relationship between parental abuse and mobile phone dependency (MPD contingent across neighborhood characteristics? A multilevel analysis of Korean Children and Youth Panel Survey.

    Directory of Open Access Journals (Sweden)

    Harris Hyun-Soo Kim

    Full Text Available Research indicates that mobile phone dependency (MPD is associated with various behavioral and internalizing problems. While a significant amount of findings points to its negative outcomes, there is a dearth of evidence concerning the determinants of MPD. This study focuses on this critical, yet understudied, subject by analyzing the associations between abusive parenting style, neighborhood characteristics, and MPD among youths in South Korea, a country with one of the highest mobile broadband penetration rates in the world. Based on the secondary analysis of two waves of Korean Children and Youth Panel Survey (KCYPS, a government-funded multiyear study, we investigate individual- and contextual-level factors underlying MPD. Findings show that, net of a host of time-lagged controls (including baseline dependency from the previous year, abusive parenting style significantly increases adolescent MPD. After adjusting for individual level characteristics, however, no contextual-level effect is found, i.e., residing in a neighborhood with a relatively higher proportion of parental abuse is not related to greater MPD. Finally, two cross-level interaction effects are observed. First, the association between parental abuse and MPD is weaker in a neighborhood context with better educated inhabitants (more college graduates. Second, it is reinforced in demographically "aged" communities with more elderly residents.

  4. Is the relationship between parental abuse and mobile phone dependency (MPD) contingent across neighborhood characteristics? A multilevel analysis of Korean Children and Youth Panel Survey.

    Science.gov (United States)

    Kim, Harris Hyun-Soo; Chun, JongSerl

    2018-01-01

    Research indicates that mobile phone dependency (MPD) is associated with various behavioral and internalizing problems. While a significant amount of findings points to its negative outcomes, there is a dearth of evidence concerning the determinants of MPD. This study focuses on this critical, yet understudied, subject by analyzing the associations between abusive parenting style, neighborhood characteristics, and MPD among youths in South Korea, a country with one of the highest mobile broadband penetration rates in the world. Based on the secondary analysis of two waves of Korean Children and Youth Panel Survey (KCYPS), a government-funded multiyear study, we investigate individual- and contextual-level factors underlying MPD. Findings show that, net of a host of time-lagged controls (including baseline dependency from the previous year), abusive parenting style significantly increases adolescent MPD. After adjusting for individual level characteristics, however, no contextual-level effect is found, i.e., residing in a neighborhood with a relatively higher proportion of parental abuse is not related to greater MPD. Finally, two cross-level interaction effects are observed. First, the association between parental abuse and MPD is weaker in a neighborhood context with better educated inhabitants (more college graduates). Second, it is reinforced in demographically "aged" communities with more elderly residents.

  5. 2-Methyl-2,4-pentanediol (MPD boosts as detergent-substitute the performance of ß-barrel hybrid catalyst for phenylacetylene polymerization

    Directory of Open Access Journals (Sweden)

    Julia Kinzel

    2017-07-01

    Full Text Available Covering hydrophobic regions with stabilization agents to solubilize purified transmembrane proteins is crucial for their application in aqueous media. The small molecule 2-methyl-2,4-pentanediol (MPD was used to stabilize the transmembrane protein Ferric hydroxamate uptake protein component A (FhuA utilized as host for the construction of a rhodium-based biohybrid catalyst. Unlike commonly used detergents such as sodium dodecyl sulfate or polyethylene polyethyleneglycol, MPD does not form micelles in solution. Molecular dynamics simulations revealed the effect and position of stabilizing MPD molecules. The advantage of the amphiphilic MPD over micelle-forming detergents is demonstrated in the polymerization of phenylacetylene, showing a ten-fold increase in yield and increased molecular weights.

  6. The CNEN Helium-Caesium Blow-Down MPD Facility and Experiments with a Prototype Duct

    Energy Technology Data Exchange (ETDEWEB)

    Bertolini, E.; Toschi, R. [CNEN, Frascati (Italy); Lindley, B. C. [C.A. Parsons and Co. Ltd (United Kingdom); Brown, R.; McNab, I. R. [International Research and Development Co. Ltd., Newcastle Upon Tyne (United Kingdom)

    1966-11-15

    The CNEN blow-down loop has been designed to study a helium-caesium MPD generator with particular regard to non-equilibrium ionization effects. An operating condition of the loop is: gas mass flow 0.2 kg/sec, seed fraction 1 at, wt.%, useful pulse duration 20 sec, stagnation temperature 2000 Degree-Sign K, stagnation pressure 5 atm abs, thermal power 1.6 MW, Mach number 0.6, magnetic field 4 Wb/m2, total impurity level less than 100 ppm. A sufficiently wide range of the stagnation conditions can be obtained with the present arrangement of the loop (temperature up to 2000*K, pressure from slightly sub-atmospheric to 6atmabs, gas mass flow from 50 g/sec to 400 g/sec, seed fraction from 0.1 to 2 at. wt.%. The storage heater is an alumina pebble bed electrically heated with tungsten elements and thermally insulated with zirconia fibre; the thermal capacity at 2000 Degree-Sign K is about 1000 MJ. Pure helium is obtained by evaporation of liquid helium at between 4.5 and 5 Degree-Sign K; liquid caesium is injected into a limited section of the pebble bed to provide a mixture of the two gases uniform in density and temperature. The duct is made of boron nitride (5 cm x 3 cm x 22 cm) with 25 pairs of tantalum electrodes whose geometry (electrode width 3 mm, segmentation pitch 9 mm) should prevent current leakage between adjacent electrodes; the duct walls and transfer can be pre-heated up to 1700 Degree-Sign K. A magnetic field of 4 Wb/m{sup 2} is obtained with a pulsed cryogenic magnet with pulse duration of 6 sec. Two series of experiments have been completed to assess the feasibility of the helium-caesium heating system and the generator duct. Heating system experiments, (a) Compatibility of alumina with tungsten, tantalum and caesium, with thermal cycling at 2000 Degree-Sign K; (b) Purification of zirconia fibre and its behaviour at high temperature, with thermal cycling at 2000 Degree-Sign K; (c) Capability of an alumina pebble bed of evaporating, heating and mixing

  7. Successful application of MPD (managed pressure drilling) for prevention, control, and detection of borehole ballooning in tight gas reservoir in Cuervito Field, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Ochoa, A.; Acevedo, O.; Nieto, L. [Petrobras (United States); Lambarria, J.E. [PEMEX Exploration and Production (Mexico); Perez, H. [Weatherford (United States)

    2011-07-01

    The Cuervito field is an oil play located in the Burgos Basin in northeastern Mexico. In order to reach the highest yielding sands, wells in the Cuervito field are usually set up with 3 casings. However, the ballooning effect, an elastoplastic behavior of a well's walls, occurs during drilling operations, leading to loss of circulation. Two methods, based on geological and geopressure data, were found to minimize this effect: either putting in an extra casing, or using an unconventional drilling technique. As the managed pressure drilling (MPD) technique is less complex and more elegant, a pilot project was implemented using this method on a well. Results showed that MPD minimized lost time and enhanced drilling efficiency. This paper demonstrated that the use of MPD in the Cuervito field is a good solution for identifying and controlling the ballooning effect and this technique was successfully applied to the next 3 wells drilled subsequently.

  8. A comparison of twice-weekly MPD-PUVA and three times-weekly skin typing-PUVA regimens for the treatment of psoriasis

    Energy Technology Data Exchange (ETDEWEB)

    Buckley, D.A.; Rogers, S. [City of Dublin Skin and Cancer Hospital, Dublin (Ireland); Healy, E. [Royal Victoria Infirmary, Newcastle upon Tyne (United Kingdom)

    1995-09-01

    The most frequent PUVA treatment regimen in current use is three times weekly, using skin typing to estimate the starting dose. Recently, it was suggested that twice-weekly treatment, using the minimal phototoxic dose- (MPD) to calculate suberythmal starting doses of UVA, achieved similar clearance rates with fewer treatments and a lower cumulative UVA dose. We have carried out a trial on 83 patients, comparing twice-weekly MPD-PUVA with three times-weekly skin typing-PUVA, in order to test this hypothesis. Although clearance rates were comparable between the two regimens, there was no overall significant difference in the number of treatments or in the cumulative UVA doses at clearance. However, for patients with skin types I and II the cumulative UVA dose was significantly higher using the twice-weekly MPD regimen (70.OJ/cm{sup 2} vs. 55.8J/cm{sup 2}; P<0.05). Our results do not confirm that there is a reduction in cumulative UVA dosage with twice-weekly MPD-PUVA. (Author).

  9. Beam test results of STS prototype modules for the future accelerator experiments FAIR/CBM and NICA/MPD projects

    Science.gov (United States)

    Kharlamov, Petr; Dementev, Dmitrii; Shitenkov, Mikhail

    2017-10-01

    High-energy heavy-ion collision experiments provide the unique possibility to create and investigate extreme states of strongly-interacted matter and address the fundamental aspects of QCD. The experimental investigation the QCD phase diagram would be a major breakthrough in our understanding of the properties of nuclear matter. The reconstruction of the charged particles created in the nuclear collisions, including the determination of their momenta, is the central detection task in high-energy heavy-ion experiments. It is taken up by the Silicon Tracking System in CBM@FAIR and by Inner Tracker in MPD@NICA currently under development. These experiments requires very fast and radiation hard detectors, a novel data read-out and analysis concept including free streaming front-end electronics. Thermal and beam tests of prototype detector modules for these tracking systems showed the stability of sensors and readout electronics operation.

  10. Beam test results of STS prototype modules for the future accelerator experiments FAIR/CBM and NICA/MPD projects

    Directory of Open Access Journals (Sweden)

    Kharlamov Petr

    2017-01-01

    Full Text Available High-energy heavy-ion collision experiments provide the unique possibility to create and investigate extreme states of strongly-interacted matter and address the fundamental aspects of QCD. The experimental investigation the QCD phase diagram would be a major breakthrough in our understanding of the properties of nuclear matter. The reconstruction of the charged particles created in the nuclear collisions, including the determination of their momenta, is the central detection task in high-energy heavy-ion experiments. It is taken up by the Silicon Tracking System in CBM@FAIR and by Inner Tracker in MPD@NICA currently under development. These experiments requires very fast and radiation hard detectors, a novel data read-out and analysis concept including free streaming front-end electronics. Thermal and beam tests of prototype detector modules for these tracking systems showed the stability of sensors and readout electronics operation.

  11. A comparative study of the effects of Ag{sub 2}S films prepared by MPD and HRTD methods on the performance of polymer solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Zhai, Yong; Li, Fumin; Ling, Lanyun [Henan Key Laboratory of Photovoltaic Materials, Henan University, Kaifeng, 475004 (China); School of Physics and Electronics, Henan University, Kaifeng, 475004 (China); Chen, Chong, E-mail: chongchen@henu.edu.cn [Henan Key Laboratory of Photovoltaic Materials, Henan University, Kaifeng, 475004 (China); School of Physics and Electronics, Henan University, Kaifeng, 475004 (China)

    2016-10-30

    Highlights: • Ag{sub 2}S nanocrystals are directly synthesized on ITO substrate by MPD and HRTD methods. • The Ag{sub 2}S films prepared by HRTD method have lower roughness and better uniformity. • The solar cells with the Ag{sub 2}S (HRTD, n) films show better device performance. - Abstract: In this work, the Ag{sub 2}S nanocrystalline thin films are deposited on ITO glass via molecular precursor decomposition (MPD) method and newly developed HRTD method for organic solar cells (ITO/Ag{sub 2}S/P3HT:PCBM/MoO{sub 3}/Au) as an electron selective layer and a light absorption material. The surface morphology, structure characterization, and optical property of the Ag{sub 2}S films prepared by these two methods were compared and the effect of the prepared Ag{sub 2}S film on the device performance is investigated. It is found that the Ag{sub 2}S films prepared by HRTD method have lower roughness and better uniformity than the corresponding films prepared by the MPD method. In addition, a more effective and rapid transporting ability for the electrons and holes in the ITO/Ag{sub 2}S(HRTD, n)/P3HT:PCBM/MoO{sub 3}/Au cells is found, which reduces the charge recombination, and thus, improves the device performance. The highest efficiency of 3.21% achieved for the ITO/Ag{sub 2}S(HRTD, 50)/P3HT:PCBM/MoO{sub 3}/Au cell is 93% higher than that of the ITO/Ag{sub 2}S(MPD, 2)/P3HT:PCBM/MoO{sub 3}/Au cell.

  12. Comprehensive performance analyses and optimization of the irreversible thermodynamic cycle engines (TCE) under maximum power (MP) and maximum power density (MPD) conditions

    International Nuclear Information System (INIS)

    Gonca, Guven; Sahin, Bahri; Ust, Yasin; Parlak, Adnan

    2015-01-01

    This paper presents comprehensive performance analyses and comparisons for air-standard irreversible thermodynamic cycle engines (TCE) based on the power output, power density, thermal efficiency, maximum dimensionless power output (MP), maximum dimensionless power density (MPD) and maximum thermal efficiency (MEF) criteria. Internal irreversibility of the cycles occurred during the irreversible-adiabatic processes is considered by using isentropic efficiencies of compression and expansion processes. The performances of the cycles are obtained by using engine design parameters such as isentropic temperature ratio of the compression process, pressure ratio, stroke ratio, cut-off ratio, Miller cycle ratio, exhaust temperature ratio, cycle temperature ratio and cycle pressure ratio. The effects of engine design parameters on the maximum and optimal performances are investigated. - Highlights: • Performance analyses are conducted for irreversible thermodynamic cycle engines. • Comprehensive computations are performed. • Maximum and optimum performances of the engines are shown. • The effects of design parameters on performance and power density are examined. • The results obtained may be guidelines to the engine designers

  13. Analytical characterization of three cathinone derivatives, 4-MPD, 4F-PHP and bk-EPDP, purchased as bulk powder from online vendors.

    Science.gov (United States)

    Apirakkan, Orapan; Frinculescu, Anca; Shine, Trevor; Parkin, Mark C; Cilibrizzi, Agostino; Frascione, Nunzianda; Abbate, Vincenzo

    2018-02-01

    Novel emerging drugs of abuse, also referred as new psychoactive substances, constitute an ever-changing mixture of chemical compounds designed to circumvent legislative controls by means of chemical modifications of previously banned recreational drugs. One such class, synthetic cathinones, namely β-keto derivatives of amphetamines, has been largely abused over the past decade. A number of new synthetic cathinones are detected each year, either in bulk powders/crystals or in biological matrices. It is therefore important to continuously monitor the supply of new synthetic derivatives and promptly report them. By using complementary analytical techniques (i.e. one- and two-dimensional NMR, FT-IR, GC-MS, HRMS and HPLC-UV), this study investigates the detection, identification and full characterization of 1-(4-methylphenyl)-2-(methylamino)pentanone (4-methylpentedrone, 4-MPD), 1-(4-fluorophenyl)-2-(pyrrolidin-1-yl)hexanone (4F-PHP) and 1-(1,3-benzodioxol-5-yl)-2-(ethylamino)-1-pentanone (bk-EPDP), three emerging cathinone derivatives. Copyright © 2017 John Wiley & Sons, Ltd.

  14. Defective graphene supported MPd12 (M = Fe, Co, Ni, Cu, Zn, Pd) nanoparticles as potential oxygen reduction electrocatalysts: A first-principles study

    KAUST Repository

    Liu, Xin

    2013-01-24

    We studied the electronic structure of MPd12 (M = Fe, Co, Ni, Cu, Zn, Pd) nanoparticles deposited on graphene substrates and their reactivity toward O adsorption, which are directly related to the catalytic performance of these composites in oxygen reduction reaction, by first-principles-based calculations. We found that the alloying between M and Pd can enhance the stability of nanoparticles and promote their oxygen reduction activity to be comparable with that of Pt(111). The defective graphene substrate can provide anchoring sites for these nanoparticles by forming strong metal-substrate interaction. The interfacial interaction can contribute to additional stability and further tune the averaged d-band center of the deposited alloy nanoparticles, resulting in strong interference on the O adsorption. As the O adsorption on these composites is weakened, the oxygen reduction reaction kinetics over these composites will also be promoted. These composites are thus expected to exhibit both high stability and superior catalytic performance in oxygen reduction reaction. © 2013 American Chemical Society.

  15. Plasma Instabilities and Transport in the MPD Thruster

    Science.gov (United States)

    1993-06-01

    driven plasma accelera- tion vesrus current-deiven energy dissipation Part III: anomalous trasnport . In 2 8’A Joint Propulsion Conference, Nashville... trasnport In the March/April Bi- monthly Progress Report of the Electric Propulsion and Plasma Dynamics Laboratory. Technical Report MAE 1776.36, EPPDyL, Princeton Univer- sity, 1992. 0 0

  16. A new multi-line cusp magnetic field plasma device (MPD) with variable magnetic field

    Science.gov (United States)

    Patel, A. D.; Sharma, M.; Ramasubramanian, N.; Ganesh, R.; Chattopadhyay, P. K.

    2018-04-01

    A new multi-line cusp magnetic field plasma device consisting of electromagnets with core material has been constructed with a capability to experimentally control the relative volume fractions of magnetized to unmagnetized plasma volume as well as accurate control on the gradient length scales of mean density and temperature profiles. Argon plasma has been produced using a hot tungsten cathode over a wide range of pressures 5 × 10-5 -1 × 10-3 mbar, achieving plasma densities ranging from 109 to 1011 cm-3 and the electron temperature in the range 1-8 eV. The radial profiles of plasma parameters measured along the non-cusp region (in between two consecutive magnets) show a finite region with uniform and quiescent plasma, where the magnetic field is very low such that the ions are unmagnetized. Beyond that region, both plasma species are magnetized and the profiles show gradients both in temperature and density. The electrostatic fluctuation measured using a Langmuir probe radially along the non-cusp region shows less than 1% (δIisat/Iisat physics parameter space relevant to both laboratory multi-scale plasmas and astrophysical plasmas.

  17. Diffuse hepatic and splenic 99mTc MPD tracer uptake in case of multiple myeloma

    International Nuclear Information System (INIS)

    Sood, Ashwani; Seam, Rajeev Kumar; Sethi, Sandeep; Gupta, Manish

    2010-01-01

    99m Tc-methylene diphosphonate (MDP) bone scintigraphy has long been used for the evaluation of benign as well as malignant skeletal conditions. However, non-osseous tracer uptake on a bone scan is an unusual finding. There is a need to understand the pathophysiological basis of the non-osseous uptake, which may have a clinical relevance or deteriorating effect on the quality of the bone scan. We describe a case of multiple myeloma, where extraosseous uptake in the form of diffuse hepatic and splenic uptake, with almost normal skeletal tracer distribution, has been seen on the bone scan. (author)

  18. The optical method of the straw selection for the MPD end-cap tracker

    International Nuclear Information System (INIS)

    Grigalashvili, N.; Kekelidze, G.D.; Myalkovskij, V.V.; Peshekhonov, V.D.

    2015-01-01

    The paper describes the optical method for measurement of the straightness deviation in the straws with a diameter of 4 mm and a length of 60 cm mounted in the ring frames of the detector and for defining the parameters for the straw selection. With this method, the maximal acceptable deviation from straightness in a straw does not exceed 400 microns and the changes of the amplitudes of signals from a 55 Fe source along the straw do not exceed 9%. The results of the optical straightness control are in good agreement with the data obtained with a more accurate method of determining the offset of the anode from the straw axis by measuring amplitude characteristics with the use of the 55 Fe source.

  19. Abreacting and Assimilating Traumatic, Dissociated Memories of MPD Patients through Art Therapy.

    Science.gov (United States)

    Jacobson, Mindy

    1994-01-01

    Notes that, when used to treat patients diagnosed with multiple personality disorder, art therapy aids in translating unspeakable memories into visual format. Discusses "stepping in," drawing process that may promote "cross-alter associations" to imagery drawn by other personalities. Addresses recovery of traumatic material…

  20. Sistem Pendukung Keputusan Penilaian Proposal Kegiatan PNPM MPd Menggunakan Metode Profile Matching dan Analytic Hierarchy Process (AHP

    Directory of Open Access Journals (Sweden)

    Ahmad Mufid

    2016-01-01

    Full Text Available Assessment of PNPM-MPd’s proposal not run quickly and objectively. The purpose of this research is to create software to help the verification team in conducting an objective assessment of the proposals using the profile matching method and the analytic hierarchy process (AHP. Profile matching method is used to provide an assessment, determination of the gap, and the weighting criteria. While the AHP method is used to calculate the pairwise comparison matrices, eigenvalues​​, priorities, maximum eigenvalues​​, consistency index (CI and consistency ratio (CR. CR values ​​are used to determine the order in which proposals will be funded by BLM. The final result of this research is decision support system software for assessment of PNPM-MPd’s proposal that can determine the rank of the highest value to lowest. Keywords : Assessment; Profile matching; Analytic Hierarchy Process (AHP

  1. Altered Gray Matter Volume and White Matter Integrity in College Students with Mobile Phone Dependence

    OpenAIRE

    Wang, Yongming; Zou, Zhiling; Song, Hongwen; Xu, Xiaodan; Wang, Huijun; d?Oleire Uquillas, Federico; Huang, Xiting

    2016-01-01

    Mobile phone dependence (MPD) is a behavioral addiction that has become an increasing public mental health issue. While previous research has explored some of the factors that may predict MPD, the underlying neural mechanisms of MPD have not been investigated yet. The current study aimed to explore the microstructural variations associated with MPD as measured with functional Magnetic Resonance Imaging (fMRI). Gray matter volume (GMV) and white matter (WM) integrity [four indices: fractional ...

  2. Marital and Family Therapy in the Treatment of Multiple Personality Disorder.

    Science.gov (United States)

    Sachs, Roberta G.; And Others

    1988-01-01

    Explores marital and family therapy in treatment of Multiple Personality Disorder (MPD), discussing role of family of origin in MPD development and role of nuclear family in its perpetuation. Suggests family and marital interventions, illustrating them with case examples. Proposes involving MPD client in marital or family therapy, in addition to…

  3. SPINning parallel systems software

    International Nuclear Information System (INIS)

    Matlin, O.S.; Lusk, E.; McCune, W.

    2002-01-01

    We describe our experiences in using Spin to verify parts of the Multi Purpose Daemon (MPD) parallel process management system. MPD is a distributed collection of processes connected by Unix network sockets. MPD is dynamic processes and connections among them are created and destroyed as MPD is initialized, runs user processes, recovers from faults, and terminates. This dynamic nature is easily expressible in the Spin/Promela framework but poses performance and scalability challenges. We present here the results of expressing some of the parallel algorithms of MPD and executing both simulation and verification runs with Spin

  4. Study on the impact of the engineering energy gain and the FPC mass power density on the generation cost of fusion power plant

    International Nuclear Information System (INIS)

    Huang Desuo; Wu Yican

    2004-01-01

    The impact of the engineering energy gain and the fusion-power-core (FPC) mass power density (MPD) on the generation cost of fusion power plant are analyzed based on the economic elasticity approach in this paper. From the functions describing the relationship of the generation cost with the engineering energy gain and the MPD, the elasticity coefficients of the generation cost with the engineering energy gain and the MPD have been derived respectively to analyze their sensitivity to the generation cost and the MPD to the generation cost decreases with increasing the engineering energy gain or the MPD. (authors)

  5. The diameter of main pancreatic duct on endoscopic retrograde pancreatography and the appearance of main pancreatic duct on computed tomography

    International Nuclear Information System (INIS)

    Tanno, Naoaki; Yamazaki, Hideo; Toyota, Takayoshi; Nakanome, Chiyuki; Sasaki, Masayoshi; Sato, Waichi; Komatsu, Kanji.

    1990-01-01

    We have carried out a comparative study of the diameter of main pancreatic duct (MPD) on endoscopic retrograde pancreatography (ERP) with the fequency of detection of MPD by computed tomography (CT) in order to clarify the importance of MPD appearance on CT in the pancreatic and biliary diseases. The normal MPD on ERP was demonstrated by CT in a low frequency. MPD was most frequently observed in the pancreatic body on CT. The dilatation of MPD on ERP was found in both moderate and advanced pancreatitis group. However, the significant demonstration of MPD by CT was found in advanced group alone. We observed that CT finding of dilated duct correlated with that on ERP in advanced group alone. (author)

  6. Prior methylphenidate self-administration alters the subsequent reinforcing effects of methamphetamine in rats.

    Science.gov (United States)

    Baladi, Michelle G; Nielsen, Shannon M; Umpierre, Anthony; Hanson, Glen R; Fleckenstein, Annette E

    2014-12-01

    Methylphenidate (MPD) is clinically effective in treating the symptoms of attention-deficit hyperactivity disorder; however, its relatively widespread availability has raised public health concerns on nonmedical use of MPD among certain adult populations. Most preclinical studies investigate whether presumed therapeutically relevant doses of MPD alter sensitivity to the reinforcing effects of other drugs, but it remains unclear whether doses of MPD likely exceeding therapeutic relevance impact the subsequent reinforcing effects of drugs. To begin to address this question, the effect of prior MPD self-administration (0.56 mg/kg/infusion) on the subsequent reinforcing effects of methamphetamine (METH, 0.032 or 0.1 mg/kg/infusion) was investigated in male Sprague-Dawley rats. For comparison, it was also determined whether prior experimenter-administered MPD, injected daily at a presumed therapeutically relevant dose (2 mg/kg), altered the subsequent reinforcing effects of METH. Results indicated that, under the current conditions, only a history of MPD self-administration increased sensitivity to the subsequent reinforcing effects of METH. Furthermore, MPD did not impact food-maintained responding, suggesting that the effect of MPD might be specific to drug reinforcers. These data suggest that short-term, nonmedical use of MPD might alter the positive reinforcing effects of METH in a manner relevant to vulnerability to drug use in humans.

  7. Blood responses under chronic low daily dose gamma irradiation: Pt. 1; Differential preclinical responses of irradiated male dogs in progression to either aplastic anemia or myeloproliferative disease

    Energy Technology Data Exchange (ETDEWEB)

    Seed, T.M.; Carnes, B.A.; Tolle, D.V.; Fritz, T.E. (Argonne National Lab., IL (USA))

    1989-01-01

    Male beagles chronically exposed to low daily doses of {sup 60}Co {gamma} rays show one of three hematopoietic patterns, which reflect three different distinctly responding subgroups: (1) low radioresistance with progressing aplastic anemia and shortened survival ({sup -S}-AA subgroup); (2) high radioresistance with a complex of progressing myeloproliferative disorders ({sup +}R-MPD group); or (3) high radioresistance with other nonMPD syndromes ({sup +}R-nonMPD group). Blood cell levels (granulocytes, monocytes, erythrocytes, lymphocytes, and platelets) were assessed and fitted to a flexible polynomial spline model. Results showed that relative to the overall magnitude of blood cell loss as well as to the maximum rate of suppression during the initial phase, the subgroups were generally ranked {sup -}S-AA >> {sup +}R-MPD > {sup +}R-nonMPD. Relative to the overall strength of the recovery response, the subgroups were generally ranked {sup +}R-MPD > {sup +}R-nonMPD >>> {sup -}S-AA. In terms of overall maintenance levels of circulating blood cells during the recovery phase, however, the {sup +}R-nonMPD subgroup consistently exhibited stronger responses than the {sup +}R-MPD subgroup. These results support our contention that selected subgroups of dogs have strong propensities to specific hematopathologies (i.e. aplastic anemia and myeloid leukemia) under chronic irradiation and that these pathology-prone animals exhibit a series of marked differential hematopoietic responses during early preclinical phases, which serve effectively to prognosticate subsequent pathological progression. (author).

  8. Blood responses under chronic low daily dose gamma irradiation: Pt.1

    International Nuclear Information System (INIS)

    Seed, T.M.; Carnes, B.A.; Tolle, D.V.; Fritz, T.E.

    1989-01-01

    Male beagles chronically exposed to low daily doses of 60 Co γ rays show one of three hematopoietic patterns, which reflect three different distinctly responding subgroups: (1) low radioresistance with progressing aplastic anemia and shortened survival ( -S -AA subgroup); (2) high radioresistance with a complex of progressing myeloproliferative disorders ( + R-MPD group); or (3) high radioresistance with other nonMPD syndromes ( + R-nonMPD group). Blood cell levels (granulocytes, monocytes, erythrocytes, lymphocytes, and platelets) were assessed and fitted to a flexible polynomial spline model. Results showed that relative to the overall magnitude of blood cell loss as well as to the maximum rate of suppression during the initial phase, the subgroups were generally ranked - S-AA >> + R-MPD > + R-nonMPD. Relative to the overall strength of the recovery response, the subgroups were generally ranked + R-MPD > + R-nonMPD >>> - S-AA. In terms of overall maintenance levels of circulating blood cells during the recovery phase, however, the + R-nonMPD subgroup consistently exhibited stronger responses than the + R-MPD subgroup. These results support our contention that selected subgroups of dogs have strong propensities to specific hematopathologies (i.e. aplastic anemia and myeloid leukemia) under chronic irradiation and that these pathology-prone animals exhibit a series of marked differential hematopoietic responses during early preclinical phases, which serve effectively to prognosticate subsequent pathological progression. (author)

  9. Computing the Skewness of the Phylogenetic Mean Pairwise Distance in Linear Time

    DEFF Research Database (Denmark)

    Tsirogiannis, Constantinos; Sandel, Brody Steven

    2014-01-01

    The phylogenetic Mean Pairwise Distance (MPD) is one of the most popular measures for computing the phylogenetic distance between a given group of species. More specifically, for a phylogenetic tree and for a set of species R represented by a subset of the leaf nodes of , the MPD of R is equal...... to the average cost of all possible simple paths in that connect pairs of nodes in R. Among other phylogenetic measures, the MPD is used as a tool for deciding if the species of a given group R are closely related. To do this, it is important to compute not only the value of the MPD for this group but also...

  10. Effect of methylphenidate on enhancement of spatial learning by novel alternated dual task.

    Science.gov (United States)

    Veetil, Praveen Kottath; Mukkadan, Joseph Kurian

    2011-01-01

    The novel alternated dual task (ADT) arranged rats to learn T-maze spontaneous alternation task and radial arm maze (RAM) task alternatively, and by doing ADT, rats could acquire the tasks more easily than non alternated dual task (NADT) group. Also retention capacity of ADT group was significantly more and ADT help to learn a complex task faster than learning it in isolation from other tasks. In the present study effect of methylphenidate (MPD), a mood elevator, known to enhance learning and memory, on ADT procedure is assessed. Also effect of ADT procedure and MPD on spatial learning and memory are compared. Different groups were assigned by administering MPD (intraperitoneal injection at a dose of 3 mg/kg body weight) during different phases of behavioural experiments, and control groups received saline injection. MPD administration increased both acquisition and retention capacities. The amelioration attained for retention of complex task by ADT procedure, could be achieved by NADT rats only by administration of MPD. The influence of ADT procedure on acquisition and retention of TM and RAM tasks were similar to the effects of MPD, especially for the RAM task. MPD at low dose is found to enhance the learning and memory capacity in rats, than deteriorating it, supporting the use of MPD as a drug to treat attention deficit hyperactive disorder. The recent reports suggesting the effect of MPD only on retention and not on acquisition could not be confirmed, as enhancement for both acquisition and retention was found in this study.

  11. Computing the Skewness of the Phylogenetic Mean Pairwise Distance in Linear Time

    DEFF Research Database (Denmark)

    Tsirogiannis, Constantinos; Sandel, Brody Steven

    2013-01-01

    to the average cost of all possible simple paths in T that connect pairs of nodes in R. Among other phylogenetic measures, the MPD is used as a tool for deciding if the species of a given group R are closely related. To do this, it is important to compute not only the value of the MPD for this group but also...

  12. Modelling and predicting the simultaneous growth of Listeria monocytogenes and psychrotolerant lactic acid bacteria in processed seafood and mayonnaise-based seafood salads

    DEFF Research Database (Denmark)

    Mejlholm, Ole; Dalgaard, Paw

    2015-01-01

    . using the classical Jameson effect to model microbial interaction. Maximum population density (MPD) values of L. monocytogenes were accurately predicted in processed seafood with a known initial cell concentration of Lactobacillus spp. For these experiments, average MPD values of 4.5 and 4.3 log (cfu...

  13. Methylphenidate: increased abuse or appropriate use?

    Science.gov (United States)

    Llana, M E; Crismon, M L

    1999-01-01

    To address the question of the significant increase in methylphenidate (MPD) prescriptions being written and to make recommendations for health care providers involved in providing care for patients with attention deficit hyperactivity disorder (ADHD) and their families. Medline search 1966-1998 for professional articles using the following search terms--methylphenidate, children, adolescents, abuse; Internet search using MPD, Ritalin, and ADHD; and Paper Chase search using methylphenidate. The available literature regarding potential abuse or diversion of MPD consists of case reports, review articles, newspaper articles, and a Drug Enforcement Administration (DEA) publication. All available literature sources were used. Although the media and DEA report significant abuse and diversion of prescribed MPD, a review of the available literature did not reveal data to substantiate these claims. Nonetheless, there are reasons to suspect that abuse and diversion occur. A potential contributing factor to abuse is the reported similarities in pharmacodynamics and pharmacokinetics between MPD and cocaine. Recommendations are made to decrease the possibility of abuse and diversion of prescribed MPD. A balanced middle ground must be found regarding the benefits of MPD and its abuse potential. Education of clinicians, patients, and family members is key in ensuring that MPD is used appropriately.

  14. Indicators of Multiple Personality Disorder for the Clinician.

    Science.gov (United States)

    Dalton, Thomas W.

    Multiple personality disorder (MPD) is now recognized as a valid diagnostic category. Occurrence may be higher than previously suspected. While physiological testing of MPD has shown significant differences between the various personalities of individuals in terms of galvanic skin response, electroencephalogram recordings, electrodermal response…

  15. A More Unified View of the Multiple Personality Disorder.

    Science.gov (United States)

    Kelley, Ronald L.; Kodman, Frank

    1987-01-01

    Offers perspective of Multiple Personality Disorder (MPD) phenomenon based on current clinical experience. Asserts that the Jmind is polypsychic with multitude of psychological systems and processes existing in conjunction with one another, that MPD individuals have fragmented or dissociated ego states due to stress on unity of sense of self, and…

  16. Multiple Personality and the Pathological Dissociation of Self.

    Science.gov (United States)

    Price, Reese E.

    This paper considers the condition of Multiple Personality Disorder (MPD), which is defined as a separation of alternating personalities by rigid boundaries and amnestic barriers. It is proposed that MPD represents the end of a continuum of a defensive dissociation of the self that can result when a child employs a dissociative splitting of self…

  17. Using Images, Metaphor, and Hypnosis in Integrating Multiple Personality and Dissociative States: A Review of the Literature.

    Science.gov (United States)

    Crawford, Carrie L.

    1990-01-01

    Reviews literature on hypnosis, imagery, and metaphor as applied to the treatment and integration of those with multiple personality disorder (MPD) and dissociative states. Considers diagnostic criteria of MPD; explores current theories of etiology and treatment; and suggests specific examples of various clinical methods of treatment using…

  18. Functional differences in yeast protein disulfide isomerases

    DEFF Research Database (Denmark)

    Nørgaard, P; Westphal, V; Tachibana, C

    2001-01-01

    PDI1 is the essential gene encoding protein disulfide isomerase in yeast. The Saccharomyces cerevisiae genome, however, contains four other nonessential genes with homology to PDI1: MPD1, MPD2, EUG1, and EPS1. We have investigated the effects of simultaneous deletions of these genes. In several...

  19. Novel Microcephalic Primordial Dwarfism Disorder Associated with Variants in the Centrosomal Protein Ninein

    DEFF Research Database (Denmark)

    Dauber, Andrew; LaFranchi, Stephen H.; Maliga, Zoltan

    2012-01-01

    Context: Microcephalic primordial dwarfism (MPD) is a rare, severe form of human growth failure in which growth restriction is evident in utero and continues into postnatal life. Single causative gene defects have been identified in a number of patients with MPD, and all involve genes fundamental...

  20. Effects of clinically relevant doses of methyphenidate on spatial memory, behavioral sensitization and open field habituation: a time related study.

    Science.gov (United States)

    Haleem, Darakhshan Jabeen; Inam, Qurrat-ul-Aen; Haleem, Muhammad Abdul

    2015-03-15

    The psychostimulant methylphenidate (MPD) is a first-line drug for the treatment of attention deficit hyperactivity disorder (ADHD). Despite acceptable therapeutic efficacy, there is limited data regarding the long-term consequences of MPD exposure over extended periods. The present study concerns effects of clinically relevant doses of MPD, administered orally to rats for an extended period, on spatial memory, behavioral sensitization and habituation to an open field. Water maze test was used to monitor memory acquisition (2 h after training), retention (day next to training), extinction (1 week after training) and reconsolidation (weekly for 4 weeks). Administration of MPD at doses of 0.25-1.0 mg/kg improved memory acquisition, retention, reconsolidation and impaired memory extinction. Treatment with 0.25 and 0.5 mg/kg MPD for 6 weeks produced a sustained increase in motor activity but higher dose (1.0 mg/kg) elicited behavioral sensitization. High as well as low doses MPD impaired open field habituation. We conclude that clinically relevant doses of MPD enhance memory even if used for extended period. It is suggested that higher (1.0 mg/kg) clinically relevant doses of MPD, if used for extended period, may exacerbate hyperactivity and impulsivity associated with the disease. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Pancreatic Duct in Autoimmune Pancreatitis: Intraindividual Comparison of Magnetic Resonance Pancreatography at 1.5 T and 3.0 T.

    Science.gov (United States)

    Kim, Jin Hee; Byun, Jae Ho; Kim, Myung-Hwan; Lee, Sung Koo; Kim, Song Cheol; Kim, Hyoung Jung; Lee, Seung Soo; Kim, So Yeon; Lee, Moon-Gyu

    2017-08-01

    The aim of this study was to intraindividually compare magnetic resonance pancreatography (MRP) image quality at 1.5 T and 3.0 T when demonstrating main pancreatic duct (MPD) abnormalities in patients with autoimmune pancreatitis (AIP). Thirty prospectively enrolled patients with AIP underwent MRP at both 1.5 T and 3.0 T followed by endoscopic retrograde pancreatography before treatment. Two readers independently analyzed the MRP images and graded the visualization of MPD strictures and full-length MPD, using endoscopic retrograde pancreatography as the reference standard, as well as overall image artifacts on a 4-point scale. The contrast between the MPD and periductal area was calculated using a region-of-interest measurement. Visualization scores of MPD strictures and full-length MPD, and summed scores of each qualitative analysis, were significantly greater at 3.0-T MRP than at 1.5-T MRP for both readers (P ≤ 0.02). There were less image artifacts at 3.0 T compared with 1.5 T (P ≤ 0.052). The contrast between the MPD and periductal area was significantly greater at 3.0-T MRP than at 1.5-T MRP (P 3.0 T was superior to 1.5-T MRP for demonstrating MPD abnormalities in AIP, with better image contrast and fewer image artifacts. Consequently, 3.0-T MRP may be useful for the diagnosis and management of patients with AIP.

  2. Los Alamos NEP research in advanced plasma thrusters

    Science.gov (United States)

    Schoenberg, Kurt; Gerwin, Richard

    1991-01-01

    Research was initiated in advanced plasma thrusters that capitalizes on lab capabilities in plasma science and technology. The goal of the program was to examine the scaling issues of magnetoplasmadynamic (MPD) thruster performance in support of NASA's MPD thruster development program. The objective was to address multi-megawatt, large scale, quasi-steady state MPD thruster performance. Results to date include a new quasi-steady state operating regime which was obtained at space exploration initiative relevant power levels, that enables direct coaxial gun-MPD comparisons of thruster physics and performance. The radiative losses are neglible. Operation with an applied axial magnetic field shows the same operational stability and exhaust plume uniformity benefits seen in MPD thrusters. Observed gun impedance is in close agreement with the magnetic Bernoulli model predictions. Spatial and temporal measurements of magnetic field, electric field, plasma density, electron temperature, and ion/neutral energy distribution are underway. Model applications to advanced mission logistics are also underway.

  3. Altered gray matter volume and white matter integrity in college students with mobile phone dependence

    Directory of Open Access Journals (Sweden)

    Yongming eWang

    2016-05-01

    Full Text Available Mobile phone dependence (MPD is a behavioral addiction that has become an increasing public mental health issue. While previous research has explored some of the factors that may predict MPD, the underlying neural mechanisms of MPD have not been investigated yet. The current study aimed to explore the microstructural variations associated with MPD as measured with functional Magnetic Resonance Imaging (fMRI. Gray matter volume (GMV and white matter (WM integrity (four indexes: fractional anisotropy, FA; mean diffusivity, MD; axial diffusivity, AD; and radial diffusivity, RD were calculated via voxel-based morphometry (VBM and tract-based spatial statistics (TBSS analysis, respectively. Sixty-eight college students (42 female were enrolled and separated into two groups (MPD group, N=34; control group, N=34 based on Mobile Phone Addiction Index (MPAI scale score. Trait impulsivity was also measured using the Barrett Impulsivity Scale (BIS-11. In light of underlying trait impulsivity, results revealed decreased GMV in the MPD group relative to controls in regions such as the right superior frontal gyrus (sFG, right inferior frontal gyrus (iFG, and bilateral thalamus (Thal. In the MPD group, GMV in the above mentioned regions was negatively correlated with scores on the MPAI. Results also showed significantly less FA and AD measures of white matter integrity in the MPD group relative to controls in bilateral hippocampal cingulum bundle fibers (CgH. Additionally, in the MPD group, FA of the CgH was also negatively correlated with scores on the MPAI. These findings provide the first morphological evidence of altered brain structure with phone-overuse, and may help to better understand the neural mechanisms of MPD in relation with other behavioral and substance addiction disorders.

  4. Altered Gray Matter Volume and White Matter Integrity in College Students with Mobile Phone Dependence.

    Science.gov (United States)

    Wang, Yongming; Zou, Zhiling; Song, Hongwen; Xu, Xiaodan; Wang, Huijun; d'Oleire Uquillas, Federico; Huang, Xiting

    2016-01-01

    Mobile phone dependence (MPD) is a behavioral addiction that has become an increasing public mental health issue. While previous research has explored some of the factors that may predict MPD, the underlying neural mechanisms of MPD have not been investigated yet. The current study aimed to explore the microstructural variations associated with MPD as measured with functional Magnetic Resonance Imaging (fMRI). Gray matter volume (GMV) and white matter (WM) integrity [four indices: fractional anisotropy (FA); mean diffusivity (MD); axial diffusivity (AD); and radial diffusivity (RD)] were calculated via voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analysis, respectively. Sixty-eight college students (42 female) were enrolled and separated into two groups [MPD group, N = 34; control group (CG), N = 34] based on Mobile Phone Addiction Index (MPAI) scale score. Trait impulsivity was also measured using the Barratt Impulsiveness Scale (BIS-11). In light of underlying trait impulsivity, results revealed decreased GMV in the MPD group relative to controls in regions such as the right superior frontal gyrus (sFG), right inferior frontal gyrus (iFG), and bilateral thalamus (Thal). In the MPD group, GMV in the above mentioned regions was negatively correlated with scores on the MPAI. Results also showed significantly less FA and AD measures of WM integrity in the MPD group relative to controls in bilateral hippocampal cingulum bundle fibers (CgH). Additionally, in the MPD group, FA of the CgH was also negatively correlated with scores on the MPAI. These findings provide the first morphological evidence of altered brain structure with mobile phone overuse, and may help to better understand the neural mechanisms of MPD in relation to other behavioral and substance addiction disorders.

  5. Altered Gray Matter Volume and White Matter Integrity in College Students with Mobile Phone Dependence

    Science.gov (United States)

    Wang, Yongming; Zou, Zhiling; Song, Hongwen; Xu, Xiaodan; Wang, Huijun; d’Oleire Uquillas, Federico; Huang, Xiting

    2016-01-01

    Mobile phone dependence (MPD) is a behavioral addiction that has become an increasing public mental health issue. While previous research has explored some of the factors that may predict MPD, the underlying neural mechanisms of MPD have not been investigated yet. The current study aimed to explore the microstructural variations associated with MPD as measured with functional Magnetic Resonance Imaging (fMRI). Gray matter volume (GMV) and white matter (WM) integrity [four indices: fractional anisotropy (FA); mean diffusivity (MD); axial diffusivity (AD); and radial diffusivity (RD)] were calculated via voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analysis, respectively. Sixty-eight college students (42 female) were enrolled and separated into two groups [MPD group, N = 34; control group (CG), N = 34] based on Mobile Phone Addiction Index (MPAI) scale score. Trait impulsivity was also measured using the Barratt Impulsiveness Scale (BIS-11). In light of underlying trait impulsivity, results revealed decreased GMV in the MPD group relative to controls in regions such as the right superior frontal gyrus (sFG), right inferior frontal gyrus (iFG), and bilateral thalamus (Thal). In the MPD group, GMV in the above mentioned regions was negatively correlated with scores on the MPAI. Results also showed significantly less FA and AD measures of WM integrity in the MPD group relative to controls in bilateral hippocampal cingulum bundle fibers (CgH). Additionally, in the MPD group, FA of the CgH was also negatively correlated with scores on the MPAI. These findings provide the first morphological evidence of altered brain structure with mobile phone overuse, and may help to better understand the neural mechanisms of MPD in relation to other behavioral and substance addiction disorders. PMID:27199831

  6. Multi-purpose deployer for ITER in-vessel maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Chang-Hwan, E-mail: Chang-Hwan.CHOI@iter.org [ITER Organization, Route de Vinon-sur-Verdon, 13115 St Paul lez Durance (France); Tesini, Alessandro; Subramanian, Rajendran [ITER Organization, Route de Vinon-sur-Verdon, 13115 St Paul lez Durance (France); Rolfe, Alan; Mills, Simon; Scott, Robin; Froud, Tim; Haist, Bernhard; McCarron, Eddie [Oxford Technologies Ltd., 7 Nuffield Way, Abingdon, OXON (United Kingdom)

    2015-10-15

    Highlights: • ITER RH system called as the multi-purpose deployer (MPD) is introduced. • The MPD performs dust and tritium inventory control, in-service inspection. • The MPD performs leak localization, in-vessel diagnostics maintenance. • The MPD has nine degrees of freedom with a payload capacity up to 2 tons. - Abstract: The multi-purpose deployer (MPD) is a general purpose in-vessel remote handling (RH) system in the ITER RH system. The MPD provides the means for deployment and handling of in-vessel tools or components inside the vacuum vessel (VV) for dust and tritium inventory control, in-service inspection, leak localization, and in-vessel diagnostics. It also supports the operation of blanket first wall maintenance and neutral beam duct liner module maintenance operations. This paper describes the concept design of the MPD. The MPD is a cask based system, i.e. it stays in the hot cell building during the machine operation, and is deployed to the VV using the cask system for the in-vessel operations. The main part of the MPD is the articulated transporter which provides transportation and positioning of the in-vessel tools or components. The articulated transporter has nine degrees of freedom with a payload capacity up to 2 tons. The articulated transporter can cover the whole internal surface of the VV by switching between the four equatorial RH ports. Additionally it can use two non-RH equatorial ports to transfer large tools or components. A concept for in-cask tool exchange is developed which minimizes the cask transportation by allowing the MPD to stay in the VV during the tool exchange.

  7. Self-Assembling Multifunctional Peptide Dimers for Gene Delivery Systems

    Directory of Open Access Journals (Sweden)

    Kitae Ryu

    2015-01-01

    Full Text Available Self-assembling multifunctional peptide was designed for gene delivery systems. The multifunctional peptide (MP consists of cellular penetrating peptide moiety (R8, matrix metalloproteinase-2 (MMP-2 specific sequence (GPLGV, pH-responsive moiety (H5, and hydrophobic moiety (palmitic acid (CR8GPLGVH5-Pal. MP was oxidized to form multifunctional peptide dimer (MPD by DMSO oxidation of thiols in terminal cysteine residues. MPD could condense pDNA successfully at a weight ratio of 5. MPD itself could self-assemble into submicron micelle particles via hydrophobic interaction, of which critical micelle concentration is about 0.01 mM. MPD showed concentration-dependent but low cytotoxicity in comparison with PEI25k. MPD polyplexes showed low transfection efficiency in HEK293 cells expressing low level of MMP-2 but high transfection efficiency in A549 and C2C12 cells expressing high level of MMP-2, meaning the enhanced transfection efficiency probably due to MMP-induced structural change of polyplexes. Bafilomycin A1-treated transfection results suggest that the transfection of MPD is mediated via endosomal escape by endosome buffering ability. These results show the potential of MPD for MMP-2 targeted gene delivery systems due to its multifunctionality.

  8. Infusion of methylphenidate into the basolateral nucleus of amygdala or anterior cingulate cortex enhances fear memory consolidation in rats

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The psychostimulant methylphenidate (MPD; also called Ritalin) is a blocker of dopamine and norepi-nephrine transporter. It has been clinically used for treatment of Attention Deficit and Hyperactivity Disorder (ADHD). There have been inconsistent reports regarding the effects of systemically adminis-tered MPD on learning and memory, either in animals or humans. In the present study, we investigated the effect of direct infusion of MPD into the basolateral nucleus of amygdala (BLA) or the anterior cin-gulate cortex (ACC) on conditioned fear memory. Rats were trained on a one-trial step-through inhibi-tory avoidance task. MPD was infused bilaterally into the BLA or the ACC, either at ‘0’ or 6 h post-training. Saline was administered as control. Memory retention was tested 48 h post-training. In-tra-BLA or intra-ACC infusion of MPD ‘0’ h but not 6 h post-training significantly improved 48-h memory retention: the MPD-treated rats had significant longer step-through latency than controls. The present results indicate that action of MPD in the BLA or the ACC produces a beneficial effect on the consoli-dation of inhibitory avoidance memory.

  9. Gated SPECT evaluation of myocardial perfusion defects and left ventricular function in chronic atrial fibrillation (CAF) patients - a prevalence study between a General Hospital (GH) and a referral Cardiology Hospital (CH)

    International Nuclear Information System (INIS)

    Rocha, G.; Guimaraes, M.; Marroni, B.; Zagoury, E.; Sprinz, C.; Andrea, S.; Louzada, A.; Ludwig, R.; Graef, C.

    2002-01-01

    Aims: to evaluate myocardial perfusion defects (MPD) prevalence and left ventricular function in CAF patients from a distinct referral basis (a GH and CH populations). Materials and Methods: a retrospective cross-sectional survey including 171 CAF (43 from GH and 128 from CH) and 5415 control patients (2222 from GH and 3193 from CH) submitted to rest/stress myocardial perfusion gated SPECT with Tc99m-MIBI. The following items were collected from CAF patients: the percentage of patients with MPD, the type (fixed, reversible or mixed) and number of segments with MPD and left ventricular ejection fraction (LVEF). The control patients percentage of MPD, their type and number were also collected. Results: CAF from GH and CH were not significantly different in the number of patients with MPD, mean number of segments affected, and LVEF. In GH patients, the CAF group had more segments with MPD (2,4x1,6 p<0,01) and lower LVEF (37%x52% p<0,01) than control group. CAF patients from CH also showed lower LVEF (40%x58% p<0,01) and more fixed MPD (40%x18% p<0,01) than their control group population. Conclusion: our data showed similar prevalence of MPD and reduced LVEF values between CAF patients from a GH and referral CH. The CAF group from CH seemed to have more fixed MPD perhaps reflecting more severe coronary artery disease population or referral bias. The data appears to support the evaluation of myocardial ischemia as a part of CAF possible etiologies. Caution is advised in LVEF evaluation of CAF patients due to increased variability of R-R interval

  10. Risk management in medical product development process using traditional FMEA and fuzzy linguistic approach: a case study

    Science.gov (United States)

    Kirkire, Milind Shrikant; Rane, Santosh B.; Jadhav, Jagdish Rajaram

    2015-12-01

    Medical product development (MPD) process is highly multidisciplinary in nature, which increases the complexity and the associated risks. Managing the risks during MPD process is very crucial. The objective of this research is to explore risks during MPD in a dental product manufacturing company and propose a model for risk mitigation during MPD process to minimize failure events. A case study approach is employed. The existing MPD process is mapped with five phases of the customized phase gate process. The activities during each phase of development and risks associated with each activity are identified and categorized based on the source of occurrence. The risks are analyzed using traditional Failure mode and effect analysis (FMEA) and fuzzy FMEA. The results of two methods when compared show that fuzzy approach avoids the duplication of RPNs and helps more to convert cognition of experts into information to get values of risk factors. The critical, moderate, low level and negligible risks are identified based on criticality; risk treatments and mitigation model are proposed. During initial phases of MPD, the risks are less severe, but as the process progresses the severity of risks goes on increasing. The MPD process should be critically designed and simulated to minimize the number of risk events and their severity. To successfully develop the products/devices within the manufacturing companies, the process risk management is very essential. A systematic approach to manage risks during MPD process will lead to the development of medical products with expected quality and reliability. This is the first research of its kind having focus on MPD process risks and its management. The methodology adopted in this paper will help the developers, managers and researchers to have a competitive edge over the other companies by managing the risks during the development process.

  11. Evaluation of pavement skid resistance using high speed texture measurement

    Directory of Open Access Journals (Sweden)

    Jay N. Meegoda

    2015-12-01

    Full Text Available Skid resistance is an important parameter for highway designs, construction, management, maintenance and safety. The purpose of this manuscript is to propose the correlation between skid resistance, which is measured as skid resistance trailer, and mean profile depth (MPD or the macro surface texture, which is measured by vehicle mounted laser, so that highway agencies can predict the skid resistance of pavement without the use of expensive and time consuming skid resistance trailer, which also causes disruption of traffic in use. In this research skid numbers and MPD from 5 new asphalt pavements and 4 old asphalt pavements were collected using a locked wheel skid trailer and a vehicle mounted laser. Using the data collected, a correlation between the skid number (SN40R collected by locked wheel skid tester and the texture data or MPD collected by a vehicle mounted laser operating at highway speeds was developed. The proposed correlation for new pavements was positive for MPD values less than 0.75 mm to reach a peak SN40R value, then there was a negative correlation as the MPD increases until the MPD value was equal to 1.1 mm and beyond the MPD value of 1.1 mm to the maximum value of 1.4 mm, SN40R value remained almost constant. There were significant data scatter for the MPD value of 0.8 mm. To explain these results, water film thickness during the friction test was calculated and the critical MPD was defined. The effect of sealed water pool on the SN40R was discussed. The test result showed a similar trend for older asphalt pavements, but with lower SN40R values due to the polishing of pavement micro-texture by traffic. Hence, a reduction factor was proposed for older pavements based on cumulative traffic volume for the above correlation to predict the skid resistance of older pavements.

  12. Effects of rumen-protected methionine, lysine, and histidine on lactation performance of dairy cows.

    Science.gov (United States)

    Giallongo, F; Harper, M T; Oh, J; Lopes, J C; Lapierre, H; Patton, R A; Parys, C; Shinzato, I; Hristov, A N

    2016-06-01

    The objective of this study was to evaluate the effects of supplementing a metabolizable protein (MP)-deficient diet with rumen-protected (RP) Met, Lys, and His, individually or combined, on the performance of lactating dairy cows. The experiment was a 9-wk randomized complete block design with 72 Holstein cows. Following a 2-wk covariate period, cows were blocked by days in milk, milk yield, and parity, and randomly assigned to 1 of the following 6 treatments: (1) MP-adequate diet [MPA; +243g/d MP balance, according to the National Research Council (2001) requirements]; (2) MP-deficient diet (MPD; -54g/d MP balance); (3) MPD supplemented with RPMet (MPDM); (4) MPD supplemented with RPLys (MPDL); (5) MPD supplemented with RPHis (MPDH); and (6) MPD supplemented with RPMet, RPLys, and RPHis (MPDMLH). Dry matter intake (DMI), yields of milk and milk components (fat, protein, lactose) and energy-corrected milk (ECM), feed and ECM feed efficiencies, and milk and plasma urea N were decreased by MPD, compared with MPA. Supplementation of the MPD diet with RPLys increased milk protein content and plasma glucose concentration and tended to increase milk urea N. Addition of RPHis tended to increase DMI, increased milk protein concentration, and numerically increased yields of milk fat, protein, and ECM. In addition to the trends for increased DMI and milk fat content, and higher milk protein concentration, supplementation of the 3 RP AA also increased yields of milk fat, protein, and ECM and ECM feed efficiency. Relative to MPA, milk N efficiency tended to be increased by MPD. Concentrations of plasma essential AA (except Met and Thr) were decreased by MPD compared with MPA. Supplementation of RPMet, RPLys, and RPHis increased plasma Met (except for MPDM), Lys, and His concentrations, respectively. Cows fed MPD had lower blood hemoglobin concentration and numerically higher plasma ghrelin than cows fed MPA. Concentration of total saturated fatty acids in milk fat were or

  13. Soft versus hard occlusal splint therapy in the management of temporomandibular disorders (TMDs

    Directory of Open Access Journals (Sweden)

    Sameh A Seifeldin

    2015-10-01

    Conclusions: Both forms of occlusal splints (soft and hard improved TMJ symptoms in patients with MPD or ID of the TMJ. However, the soft occlusal splints exhibited superior results after 4 months of use.

  14. Minor psychiatric disorders among Brazilian ragpickers: a cross-sectional study

    Science.gov (United States)

    da Silva, Marcelo Cozzensa; Fassa, Anaclaudia Gastal; Kriebel, David

    2006-01-01

    Background Ragpickers are informal workers who collect recyclable materials to earn a small wage. Their life and working conditions are extremely difficult. We examined minor psychiatric disorders (MPD) among a cohort of ragpickers in Pelotas, a city in southern Brazil. Methods Ragpickers were matched by sex, age, and years of schooling with a sample of non-ragpickers from the same poor neighborhoods. The cross-sectional study gathered data by interview on 990 individuals in 2004. MPD were assessed using a standard self-reporting questionnaire, the SRQ-20. Results The prevalence of MPD among ragpickers was 44.7%, higher than reported by neighborhood controls (33.6%; p work accidents. Conclusion Ragpickers more frequently report MPD than other poor workers living in the same neighborhoods, with many of the same life conditions. Improving the work lives of these precarious workers should address not only the physical hazards of their jobs but their mental and emotional health as well. PMID:16734911

  15. Poor mental health associated with job dissatisfaction among school teachers in Japan.

    Science.gov (United States)

    Nagai, Michiko; Tsuchiya, Kenji J; Toulopoulou, Timothea; Takei, Nori

    2007-11-01

    School teaching is regarded as a stressful occupation. The present study aimed to compare the likelihood of having minor psychiatric disorders (MPD) among school teachers with that among civil servants, and to investigate what factors were specifically associated with MPD in teachers. We conducted a questionnaire-based survey of 403 teachers employed at state schools and 611 civil servants as a comparison group in a medium-sized city in Japan. The response rate was 59.6% for teachers and 62.0% for civil servants. Mental health was assessed using the 28-item General Health Questionnaire (GHQ-28), according to which those with a score of six or higher were considered to have MPD. Logistic regression analysis was used to identify the factors associated with MPD. Although the proportion of subjects with MPD among teachers was greater than that among civil servants, the difference in the proportion was not statistically significant in the multiple logistic regression analysis adjusted for potential confounders. In a separate analysis of the teachers, reduced job satisfaction and shorter time spent of leisure were significantly associated with an increased likelihood of having MPD. In the group of civil servants, longer working hours, reduced life satisfaction, a history of sick leave, and physical illness were associated with an increased likelihood of having MPD. When this analysis was conducted separately for male and female teachers, job dissatisfaction alone was associated with MPD only in female teachers. Poor mental health of Japanese school teachers, female teachers in particular, was found to be associated with job dissatisfaction.

  16. Studies on 99Tcm-sulfur colloid bone marrow scintigraphy in myeloproliferative disorders

    International Nuclear Information System (INIS)

    Liu Yong; Zhang Yifan; Jia Fangxian; Kang Fu; Jian Shiquan

    2002-01-01

    Objective: To discuss the imaging features and changing patterns of bone marrow scintigraphy in myeloproliferative disorders (MPD) as well as its clinical significance. Methods: Bone marrow scintigraphy using 99 Tc m -sulfur colloid 370-550 MBq was performed on 85 MPD patients, including 40 cases of idiopathic myelofibrosis (IMF), 15 of polycythemia vera (PV), 5 of essential thrombocythaemia (ET), 30 of chronic granulocytic leukemia. Also, 40 cases of myelodysplastic syndromes (MDS) were observed in this study. Results: Abnormal bone marrow imaging was found in 88.2% of the 85 patients. The suppression rate of central bone marrow (CBM) and expansion rate of peripheral bone marrow (PBM) in these MPD patients were 61.2% and 56.5%, respectively. The imaging patterns was classified into three types according to the distribution and activity of bone marrow. 1) reduced imaging (31.8%); 2) increased and expanded imaging (27.1%); 3) depressed and expanded imaging (29.4%). Splenomegaly with minimal residual marrow activity was typical for late stages of MPD. Expansion of PBM was the further feature, but of no major importance for improving hematopoiesis of MPD, and it tended to retract during clinical recovery in chronic granulocytic leukemia (CGL). With expanding PBM, unmatched peripheral blood decreasing was found in MDS. The expansion pattern of PBM in different MPD was of relatively definite features. Conclusions: The imaging pattern of bone marrow was correlated with blood work-up data and clinical course or stages of MPD. Bone marrow scintigraphy may be proven useful in differential diagnosis and evaluation of clinical staging and prognosis of MPD

  17. Natural compound methyl protodioscin protects against intestinal inflammation through modulation of intestinal immune responses

    OpenAIRE

    Zhang, Rongli; Gilbert, Shila; Yao, Xinsheng; Vallance, Jefferson; Steinbrecher, Kris; Moriggl, Richard; Zhang, Dongsheng; Eluri, Madhu; Chen, Haifeng; Cao, Huiqing; Shroyer, Noah; Denson, Lee; Han, Xiaonan

    2015-01-01

    Dioscoreaceae, a kind of yam plant, has been recommended for treatment of chronic inflammatory conditions. However, the mechanisms are poorly defined. Methyl protodioscin (MPD) is one of the main bioactive components in Dioscoreaceae. Here, we aim to determine the mechanisms by which MPD ameliorates intestinal inflammation. Surgical intestinal specimens were collected from inflammatory bowel diseases (IBD) patients to perform organ culture. Experimental colitis was induced in mice by dextran ...

  18. Does optic nerve head surface topography change prior to loss of retinal nerve fiber layer thickness: a test of the site of injury hypothesis in experimental glaucoma.

    Directory of Open Access Journals (Sweden)

    Brad Fortune

    Full Text Available To test the hypothesis that optic nerve head (ONH deformation manifesting as changes in its mean surface height precedes thinning of the peripapillary retinal nerve fiber layer (RNFL in experimental glaucoma (EG.68 rhesus macaque monkeys each had three or more baseline imaging sessions under manometric intraocular pressure (IOP control to obtain average RNFL thickness (RNFLT and the ONH surface topography parameter mean position of the disc (MPD. Laser photocoagulation was then applied to the trabecular meshwork of one eye to induce chronic, mild-to-moderate IOP elevation and bi-weekly imaging continued. Event analysis was applied to determine for each parameter when an 'endpoint' occurred (signficant change from baseline for eight different endpoint criteria. Specificity was assessed in the group of 68 fellow control eyes. Classical signal detection theory and survival analysis were used to compare MPD with RNFLT.Regardless of the endpoint criterion, endpoints were always more frequent for MPD than for RNFLT. The discriminability index (d' was 2.7 ± 0.2 for MPD and 1.9 ± 0.2 for RNFLT (p<0.0001. Endpoints were reached by MPD an average of 1-2 months earlier than by RNFLT (p<0.01. At the onset of the first specific, detectable MPD change in EG eyes, there was still no significant change in RNFLT on average (p=0.29 and only 25% of individual eyes exhibited signficant reduction. In contrast, at onset of signficant RNFLT change, MPD had already changed an average of 101 µm from baseline (p<0.0001 and 71% of the individual eyes had exhibited significant change. The magnitude of MPD change was more than could be explained on the basis of axon loss alone.This study demonstrates that the average surface height of the ONH changes prior to any detectable loss of average peripapillary RNFL thickness in non-human primate eyes with experimental glaucoma.

  19. Pancreatic duct abnormalities in focal autoimmune pancreatitis: MR/MRCP imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Negrelli, Riccardo; Manfredi, Riccardo; Pedrinolla, Beatrice; Boninsegna, Enrico; Ventriglia, Anna; Mehrabi, Sara; Pozzi Mucelli, Roberto [G.B. Rossi University Hospital, University of Verona, Department of Radiology, Verona (Italy); Frulloni, Luca [Universita di Verona, Department of Gastroenterology, Policlinico G.B. Rossi, Verona (Italy)

    2014-08-09

    To evaluate the magnetic resonance (MR) imaging-MR cholangiopancreatographic (MRCP) findings of focal forms of autoimmune pancreatitis (AIP) to describe ductal involvement at diagnosis. MR examinations of 123 patients affected by AIP were analysed. We included 26 patients who satisfied International Consensus Diagnostic Criteria and were suffering from focal AIP. Image analysis included: site of parenchymal enlargement, main pancreatic duct (MPD) diameter, MPD stenosis, stricture length, presence of upstream dilation within the stricture, signal intensity, and pancreatic enhancement. Signal intensity abnormalities were localized in the head in 10/26 (38.5 %) and in the body-tail in 16/26 (61.5 %) patients. MRCP showed a single MPD stenosis in 12/26 (46.1 %) and multiple MPD stenosis in 14/26 (53.8 %) patients, without a dilation of the upstream MPD (mean: 3.83 mm). Lesions showed hypointensity on T1-weighted images in all patients, and hyperintensity on T2-weighted images in 22/26 (84.6 %) patients. The affected parenchyma was hypovascular during the arterial phase in 25/26 (96.2 %) patients with contrast retention. MR-MRCP are effective techniques for the diagnosis of AIP showing the loss of the physiological lobulation and the typical contrastographic appearance. The presence of multiple, long stenoses without an upstream MPD dilation at MRCP suggests the diagnosis of AIP, and can be useful in differential diagnosis of pancreatic adenocarcinoma. (orig.)

  20. JAK2 inhibitor therapy in myeloproliferative disorders: rationale, preclinical studies and ongoing clinical trials.

    Science.gov (United States)

    Pardanani, A

    2008-01-01

    The recent identification of somatic mutations such as JAK2V617F that deregulate Janus kinase (JAK)-signal transducer and activator of transcription signaling has spurred development of orally bioavailable small-molecule inhibitors that selectively target JAK2 kinase as an approach to pathogenesis-directed therapy of myeloproliferative disorders (MPD). In pre-clinical studies, these compounds inhibit JAK2V617F-mediated cell growth at nanomolar concentrations, and in vivo therapeutic efficacy has been demonstrated in mouse models of JAK2V617F-induced disease. In addition, ex vivo growth of progenitor cells from MPD patients harboring JAK2V617F or MPLW515L/K mutations is also potently inhibited. JAK2 inhibitors currently in clinical trials can be grouped into those designed to primarily target JAK2 kinase (JAK2-selective) and those originally developed for non-MPD indications, but that nevertheless have significant JAK2-inhibitory activity (non-JAK2 selective). This article discusses the rationale for using JAK2 inhibitors for the treatment of MPD, as well as relevant aspects of clinical trial development for these patients. For instance, which group of MPD patients is appropriate for initial Phase I studies? Should JAK2V617F-negative MPD patients be included in the initial studies? What are the likely consequences of 'off-target' JAK3 and wild-type JAK2 inhibition? How should treatment responses be monitored?

  1. Imaging diagnosis of intraductal papillary mucinous tumor of the pancreas

    International Nuclear Information System (INIS)

    Zhang Huimao; Lai Ying; Yang Shuqin; Yang Haishan; Murakami, K.

    2005-01-01

    Objective: To explore the diagnostic value of intraductal papillary mucinous tumor (IPMT) of the pancreas, and to assess its clinical and characteristic radiological features. Methods: Thirty-six cases with IPMT who underwent CT and MRI with plain and contrast enhancement before operation were reviewed. The clinical presentation and characteristic imaging findings of main duct type (8 cases) and branch duct type (28 cases) were retrospectively reviewed. Results: Typical imaging findings of main duct type were segmental or diffuse dilation of MPD (diameter was over 9 mm) with enhanced mural nodules after contrast medium administration. MR cholangiopancreatography (MRCP) showed dilation of MPD with flat/nodule filling defects in 4 cases and MPD dilatation in the head side in 2 cases. Branch duct type was more frequently located in the head or uncinate. Typical imaging findings of branch duct type were unilocular or multilocular cystic tumors with septa, mural nodules, and MPD dilatation. MRCP showed septa in 24 cases, filling defects in 15 cases, and MPD dilatation in 8 cases. Communication between the cystic lesion and the MPD was demonstrated in 19 cases by MRCP. Conclusion: It is extremely important to accurately make the diagnosis of IPMT for planning the surgical strategy. MRCP is a noninvasive and useful method in detecting and making definite diagnosis of IPMT. (authors)

  2. Thin porphyrin composite membranes with enhanced organic solvent transport

    KAUST Repository

    Phuoc, Duong

    2018-05-01

    Extending the stability of polymeric membranes in organic solvents is important for applications in chemical and pharmaceutical industry. Thin-film composite membranes with enhanced solvent permeance are proposed, using porphyrin as a building block. Hybrid polyamide films are formed by interfacial polymerization of 5,10,15,20-(tetra-4-aminophenyl)porphyrin/m-phenylene diamine (MPD) mixtures with trimesoyl chloride. Porphyrin is a non-planar molecule, containing a heterocyclic tetrapyrrole unit. Its incorporation into a polyamide film leads to higher free volume than that of a standard polyamide film. Polyamide films derived from porphyrin and MPD amines with a fixed total amine concentration of 1wt% and various porphyrin/MPD ratios were fabricated and characterized. The porphyrin/MPD polyamide film was complexed with Cu(II), due to the binding capacity of porphyrin to metal ions. By coupling scanning transmission electron microscopy (STEM) with electron energy-loss spectroscopy (EELS), Cu mapping was obtained, revealing the distribution of porphyrin in the interfacial polymerized layer. By using porphyrin as amine-functionalized monomer a membrane with thin selective skin and enhanced solvent transport is obtained, with good dye selectivity in the nanofiltration range. For instance, an ultra-fast hexane permeance, 40-fold increased, was confirmed when using 0.5/0.5 porphyrin/MPD mixtures, instead of only MPD as amine monomer. A rejection of 94.2% Brilliant Blue R (826g/mol) in methanol was measured.

  3. Structural analysis of ITER multi-purpose deployer

    International Nuclear Information System (INIS)

    Manuelraj, Manoah Stephen; Dutta, Pramit; Gotewal, Krishan Kumar; Rastogi, Naveen; Tesini, Alessandro; Choi, Chang-Hwan

    2016-01-01

    Highlights: • System modelling for structural analysis of the Multi-Purpose Deployer (MPD). • Finite element modeling of the Multi-Purpose Deployer (MPD). • Static, modal and seismic response analysis of the Multi-Purpose Deployer (MPD). • Iterative structural analysis and design update to satisfy the structural criteria. • Modal analysis for various kinematic configurations. • Reaction force calculations on the interfacing systems. - Abstract: The Multi-Purpose Deployer (MPD) is a general purpose ITER in-vessel remote handling (RH) system. The main handling equipment, known as the MPD Transporter, consists of a series of linked bodies, which provide anchoring to the vacuum vessel port and an articulated multi-degree of freedom motion to perform various in-vessel maintenance tasks. During the in-vessel operations, the structural integrity of the system should be guaranteed against various operational and seismic loads. This paper presents the structural analysis results of the concept design of the MPD Transporter considering the seismic events. Static structural, modal and frequency response spectrum analyses have been performed to verify the structural integrity of the system, and to provide reaction forces to the interfacing systems such as vacuum vessel and cask. Iterative analyses and design updates are carried out based on the reference design of the system to improve the structural behavior of the system. The frequency responses of the system in various kinematics and payloads are assessed.

  4. Determination of the minimal phototoxic dose and colorimetry in psoralen plus ultraviolet A radiation therapy.

    Science.gov (United States)

    Kraemer, Cristine Kloeckner; Menegon, Dóris Baratz; Cestari, Tania Ferreira

    2005-10-01

    The use of an adequate initial dose of ultraviolet A (UVA) radiation for photochemotherapy is important to prevent burns secondary to overdosage, meanwhile avoiding a reduced clinical improvement and long-term risks secondary to underdosage. The ideal initial dose of UVA can be achieved based on the phototype and the minimal phototoxic dose (MPD). The objective measurement of constitutive skin color (colorimetry) is another method commonly used to quantify the erythematous skin reaction to ultraviolet radiation exposure. The aim of this study was to determine variations in MPD and constitutional skin color (coordinate L(*)) within different phototypes in order to establish the best initial dose of UVA radiation for photochemotherapy patients. Thirty-six patients with dermatological conditions and 13 healthy volunteers were divided into five groups according to phototype. Constitutional skin color of the infra-axillary area was assessed by colorimetry. The infra-axillary area was subsequently divided into twelve 1.5 cm(2) regions to determine the MPD; readings were performed 72 h after oral administration of 8-methoxypsoralen (MOP) followed by exposure of the demarcated regions to increasing doses of UVA. The majority of the participants were women (73.5%) and their mean age was 38.8 years. The MPD ranged from 4 to 12 J/cm(2) in phototypes II and III; from 10 to 18 J/cm(2) in type IV; from 12 to 24 J/cm(2) in type V and from 18 to 32 J/cm(2) in type VI. The analysis of colorimetric values (L(*) coordinate) and MPD values allowed the definition of three distinctive groups of individuals composed by phototypes II and III (group 1), types IV and V (group 2), and phototype VI (group 3). MPD and L(*) coordinate showed variation within the same phototype and superposition between adjacent phototypes. The values of the L(*) coordinate and the MPD lead to the definition of three distinct sensitivity groups: phototypes II and III, IV and V and type VI. Also, the MPD values

  5. Dose-response characteristics of methylphenidate on locomotor behavior and on sensory evoked potentials recorded from the VTA, NAc, and PFC in freely behaving rats

    Directory of Open Access Journals (Sweden)

    Swann Alan C

    2006-01-01

    Full Text Available Abstract Background Methylphenidate (MPD is a psychostimulant commonly prescribed for attention deficit/hyperactivity disorder. The mode of action of the brain circuitry responsible for initiating the animals' behavior in response to psychostimulants is not well understood. There is some evidence that psychostimulants activate the ventral tegmental area (VTA, nucleus accumbens (NAc, and prefrontal cortex (PFC. Methods The present study was designed to investigate the acute dose-response of MPD (0.6, 2.5, and 10.0 mg/kg on locomotor behavior and sensory evoked potentials recorded from the VTA, NAc, and PFC in freely behaving rats previously implanted with permanent electrodes. For locomotor behavior, adult male Wistar-Kyoto (WKY; n = 39 rats were given saline on experimental day 1 and either saline or an acute injection of MPD (0.6, 2.5, or 10.0 mg/kg, i.p. on experimental day 2. Locomotor activity was recorded for 2-h post injection on both days using an automated, computerized activity monitoring system. Electrophysiological recordings were also performed in the adult male WKY rats (n = 10. Five to seven days after the rats had recovered from the implantation of electrodes, each rat was placed in a sound-insulated, electrophysiological test chamber where its sensory evoked field potentials were recorded before and after saline and 0.6, 2.5, and 10.0 mg/kg MPD injection. Time interval between injections was 90 min. Results Results showed an increase in locomotion with dose-response characteristics, while a dose-response decrease in amplitude of the components of sensory evoked field responses of the VTA, NAc, and PFC neurons. For example, the P3 component of the sensory evoked field response of the VTA decreased by 19.8% ± 7.4% from baseline after treatment of 0.6 mg/kg MPD, 37.8% ± 5.9% after 2.5 mg/kg MPD, and 56.5% ± 3.9% after 10 mg/kg MPD. Greater attenuation from baseline was observed in the NAc and PFC. Differences in the intensity of

  6. Multidetector CT Findings and Differential Diagnoses of Malignant Pleural Mesothelioma and Metastatic Pleural Diseases in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yoon Kyung [Department of Radiology, Gachon University Gil Medical Center, Incheon 21565 (Korea, Republic of); Kim, Jeung Sook [Department of Radiology, Dongguk University Ilsan Hospital, Goyang 10326 (Korea, Republic of); Lee, Kyung Won [Department of Radiology, Seoul National University Bundang Hospital, Seongnam 13620 (Korea, Republic of); Yi, Chin A [Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351 (Korea, Republic of); Koo, Jin Mo [Department of Radiology, Seoul National University College of Medicine, Seoul 03080 (Korea, Republic of); Jung, Soon-Hee [Department of Pathology, Yonsei University Wonju College of Medicine, Wonju 26426 (Korea, Republic of)

    2016-11-01

    To compare the multidetector CT (MDCT) features of malignant pleural mesothelioma (MPM) and metastatic pleural disease (MPD). The authors reviewed the MDCT images of 167 patients, 103 patients with MPM and 64 patients with MPD. All 167 cases were pathologically confirmed by sonography-guided needle biopsy of pleura, thoracoscopic pleural biopsy, or open thoracotomy. CT features were evaluated with respect to pleural effusion, pleural thickening, invasion of other organs, lung abnormality, lymphadenopathy, mediastinal shifting, thoracic volume decrease, asbestosis, and the presence of pleural plaque. Pleural thickening was the most common CT finding in MPM (96.1%) and MPD (93.8%). Circumferential pleural thickening (31.1% vs. 10.9%, odds ratio [OR] 3.670), thickening of fissural pleura (83.5% vs. 67.2%, OR 2.471), thickening of diaphragmatic pleura (90.3% vs. 73.4%, OR 3.364), pleural mass (38.8% vs. 23.4%, OR 2.074), pericardial involvement (56.3% vs. 20.3%, OR 5.056), and pleural plaque (66.0% vs. 21.9%, OR 6.939) were more frequently seen in MPM than in MPD. On the other hand, nodular pleural thickening (59.2% vs. 76.6%, OR 0.445), hilar lymph node metastasis (5.8% vs. 20.3%, OR 0.243), mediastinal lymph node metastasis (10.7% vs. 37.5%, OR 0.199), and hematogenous lung metastasis (9.7% vs. 29.2%, OR 0.261) were less frequent in MPM than in MPD. When we analyzed MPD from extrathoracic malignancy (EMPD) separately and compared them to MPM, circumferential pleural thickening, thickening of interlobar fissure, pericardial involvement and presence of pleural plaque were significant findings indicating MPM than EMPD. MPM had significantly lower occurrence of hematogenous lung metastasis, as compared with EMPD. Awareness of frequent and infrequent CT findings could aid in distinguishing MPM from MPD.

  7. Multidetector CT findings and differential diagnoses of malignant pleural mesothelioma and metastatic pleural diseases in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yoon Kyung [Dept. of Radiology, Gachon University Gil Medical Center, Incheon (Korea, Republic of); Kim, Jeung Sook [Dept. of Radiology, Dongguk University Ilsan Hospital, Goyang (Korea, Republic of); Lee, Kyung Won [Dept. of Radiology, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Yi, Chin A [Dept. of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Koo, Jin Mo [Dept. of Radiology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Jung, Soon Hee [Dept. of Pathology, Yonsei University Wonju College of Medicine, Wonju (Korea, Republic of)

    2016-07-15

    To compare the multidetector CT (MDCT) features of malignant pleural mesothelioma (MPM) and metastatic pleural disease (MPD). The authors reviewed the MDCT images of 167 patients, 103 patients with MPM and 64 patients with MPD. All 167 cases were pathologically confirmed by sonography-guided needle biopsy of pleura, thoracoscopic pleural biopsy, or open thoracotomy. CT features were evaluated with respect to pleural effusion, pleural thickening, invasion of other organs, lung abnormality, lymphadenopathy, mediastinal shifting, thoracic volume decrease, asbestosis, and the presence of pleural plaque. Pleural thickening was the most common CT finding in MPM (96.1%) and MPD (93.8%). Circumferential pleural thickening (31.1% vs. 10.9%, odds ratio [OR] 3.670), thickening of fissural pleura (83.5% vs. 67.2%, OR 2.471), thickening of diaphragmatic pleura (90.3% vs. 73.4%, OR 3.364), pleural mass (38.8% vs. 23.4%, OR 2.074), pericardial involvement (56.3% vs. 20.3%, OR 5.056), and pleural plaque (66.0% vs. 21.9%, OR 6.939) were more frequently seen in MPM than in MPD. On the other hand, nodular pleural thickening (59.2% vs. 76.6%, OR 0.445), hilar lymph node metastasis (5.8% vs. 20.3%, OR 0.243), mediastinal lymph node metastasis (10.7% vs. 37.5%, OR 0.199), and hematogenous lung metastasis (9.7% vs. 29.2%, OR 0.261) were less frequent in MPM than in MPD. When we analyzed MPD from extrathoracic malignancy (EMPD) separately and compared them to MPM, circumferential pleural thickening, thickening of interlobar fissure, pericardial involvement and presence of pleural plaque were significant findings indicating MPM than EMPD. MPM had significantly lower occurrence of hematogenous lung metastasis, as compared with EMPD. Awareness of frequent and infrequent CT findings could aid in distinguishing MPM from MPD.

  8. Functional diversity through the mean trait dissimilarity: resolving shortcomings with existing paradigms and algorithms.

    Science.gov (United States)

    de Bello, Francesco; Carmona, Carlos P; Lepš, Jan; Szava-Kovats, Robert; Pärtel, Meelis

    2016-04-01

    While an increasing number of indices for estimating the functional trait diversity of biological communities are being proposed, there is a growing demand by ecologists to clarify their actual implications and simplify index selection. Several key indices relate to mean trait dissimilarity between species within biological communities. Among them, the most widely used include (a) the mean species pairwise dissimilarity (MPD) and (b) the Rao quadratic entropy (and related indices). These indices are often regarded as redundant and promote the unsubstantiated yet widely held view that Rao is a form of MPD. Worryingly, existing R functions also do not always simplify the use and differentiation of these indices. In this paper, we show various distinctions between these two indices that warrant mathematical and biological consideration. We start by showing an existing form of MPD that considers species abundances and is different from Rao both mathematically and conceptually. We then show that the mathematical relationship between MPD and Rao can be presented simply as Rao = MPD × Simpson, where the Simpson diversity index is defined as 1 - dominance. We further show that this relationship is maintained for both species abundances and presence/absence. This evidence dismantles the paradigm that the Rao diversity is an abundance-weighted form of MPD and indicates that both indices can differ substantially at low species diversities. We discuss the different interpretations of trait diversity patterns in biological communities provided by Rao and MPD and then provide a simple R function, called "melodic," which avoids the unintended results that arise from existing mainstream functions.

  9. Influence of pore structure and chemical properties of supported Mo catalysts on their performance in upgrading heavy coal liquids

    Energy Technology Data Exchange (ETDEWEB)

    Song, C.; Hanaoka, K.; Nomura, M. (Pennsylvania State University, University Park, PA (USA). Dept. of Materials Science and Engineering)

    In the hydroprocessing of solvent-refined coals, both the pore structure and the chemical properties of the catalysts affect the conversion of the heavy materials. Increasing median pore diameter (MPD) of unimodal Ni-Mo/Al[sub 2]O[sub 3] catalysts in the relatively small pore region (up to 150 [angstrom]) enhanced the conversion of both asphaltene and preasphaltene, but further increasing the MPD up to 730 [angstrom] mainly promoted preasphaltene conversion. In the runs of the isolated fractions, however, conversions increased with MPD up to 290 [angstrom] for asphaltene and up to 730 [angstrom] for preasphaltene. The degree of heteroatom removal is also influenced by MPD. There exist preferable pore size ranges for hydrodeoxygenation. Two Mo/SiO[sub 2] and several carbon-coated Ni-Mo/Al[sub 2]O[sub 3] catalysts with different MPD and a commercial Ni-Mo supported on silicated Al[sub 2]O[sub 3] were also compared. The increasing MPD of SiO[sub 2]-supported Mo catalysts increased the conversion of preasphaltene materials. Mo/SiO[sub 2] catalysts are more effective than Ni-Mo supported on Al[sub 2]O[sub 3] and silicated Al[sub 2]O[sub 3] for converting preasphaltene materials, while the latter two are more active for conversion of asphaltene into oil. Another interesting observation is that, for a given MPD range, the carbon-coated Ni-Mo/Al[sub 2]O[sub 3] catalysts gave higher preasphaltene conversions than fresh ones. These results point to the conclusion that larger pore and less acidic hydrogenation catalysts are more effective for preasphaltene conversion, but efficient conversion of asphaltene into oil is facilitated by mild hydrocracking catalysts having appropriate pore size ranges. 43 refs., 8 figs., 9 tabs.

  10. Seismic analysis of ITER multi-purpose deployer

    International Nuclear Information System (INIS)

    Manuelraj, Manoah Stephen; Gotewal, Krishan Kumar; Dutta, Pramit; Rastogi, Naveen; Choi, Chang-Hwan; Tesini, Alessandro

    2015-01-01

    The Multi-Purpose Deployer (MPD) is a general purpose ITER in-vessel remote handling (RH) system. The MPD will perform various in-vessel maintenance tasks such as dust and tritium inventory control, in-service inspection, leak localization and in-vessel diagnostics maintenance. The main handling equipment, called as the MPD Transporter, consists of a series of linked bodies, which provide anchoring to the vacuum vessel port and an articulated multi-degree of freedom motion to perform the aforementioned tasks. The target payload for the MPD Transporter is 2 tons. The total length is 16.6 m and 18.1 m for short and long configuration respectively, while the total weight of the system is about 25.5 tons including the payload. During the in-vessel operations, the structural integrity of the system should be guaranteed against various operational and seismic loads. This paper presents the seismic structural analysis results of the concept design of the MPD Transporter. Static structural, modal and frequency response spectrum analyses have been performed to verify the structural integrity of the MPD itself, and to provide reaction loads to the interfacing systems such as vacuum vessel and cask. The analyses are carried out by using the ANSYS. The first analysis iteration was carried out for the reference design of the MPD Transporter, which showed stresses higher than the permissible limit. Structural optimizations and reinforcements were performed for individual bodies referring the stress levels in each body, and a reinforced design was proposed. The reinforced design satisfies the required structural criteria in terms of general global stresses. Though local stress concentrations were observed, it can be solved in the next design phase by further local reinforcements or proper material choice. (author)

  11. Audit Of The Prevalence Of Malnutrition Using The Modified Subjective Global Assessment Tool In Maintenance Peritoneal Dialysis Patients In The Top End Renal Service Of The Nortehrn Territory Australia

    Directory of Open Access Journals (Sweden)

    Greta Hollis

    2012-06-01

    Full Text Available The objective of the audit is to determine the prevalence of malnutrition in maintenance peritoneal dialysis (MPD patients in the Top End of the Northern Territory, using the modified Subjective Global Assessment (SGA tool. Methods: The audit was conducted in an outpatients setting. Approximately 75% of PD patients in the Top End Renal service are represented by Aboriginal and Torres Strait Island people. The study population was MPD patients in the Top End Renal Service (TERS of the Northern Territory, from January 1st 2010 to December 31st 2010. Results were compared to malnutrition rates found in the 2008/09 the audit of MPD patients in the TERS. The SGA’s were performed by the renal Dietitian as part of the standard dietetic support of MPD patients. SGA scores were collected from patient medical charts. Results: Patients were classified into one of three categories, based on their SGA score (A Well-nourished; (B Mild- Moderate Malnutrition, (C Severe malnutrition. Malnutrition (B or C was detected in 10% of PD patients, compared to the 2008/09 audit where 76% of MPD patients had some degree of malnutrition. Summary: These results were much lower than malnutrition rates (76% in the MPD patients audited in 2008/09. A number of factors affecting the PD service after the 2008/09 audit could explain the decrease in malnutrition rates including the implementation of free oral nutrition supplements to MPD patients, development of service wide culturally appropriate education resources used in the pre-dialysis and dialysis stage. Future research into the correlation between improved peritonitis rates and decreased malnutrition rates in the population are warranted.

  12. Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefrontal Cortex of Spontaneously Hypertensive Rats.

    Directory of Open Access Journals (Sweden)

    Maurício dos Santos Pereira

    Full Text Available Methylphenidate (MPD is one of the most prescribed drugs for alleviating the symptoms of Attention Deficit/Hyperactivity Disorder (ADHD. However, changes in the molecular mechanisms related to MPD withdrawal and susceptibility to consumption of other psychostimulants in normal individuals or individuals with ADHD phenotype are not completely understood. The aims of the present study were: (i to characterize the molecular differences in the prefrontal dopaminergic system of SHR and Wistar strains, (ii to establish the neurochemical consequences of short- (24 hours and long-term (10 days MPD withdrawal after a subchronic treatment (30 days with Ritalin® (Methylphenidate Hydrochloride; 2.5 mg/kg orally, (iii to investigate the dopaminergic synaptic functionality after a cocaine challenge in adult MPD-withdrawn SHR and Wistar rats. Our results indicate that SHR rats present reduced [3H]-Dopamine uptake and cAMP accumulation in the prefrontal cortex (PFC and are not responsive to dopaminergic stimuli in when compared to Wistar rats. After a 24-hour withdrawal of MPD, SHR did not present any alterations in [3H]-Dopamine Uptake, [3H]-SCH 23390 binding and cAMP production; nonetheless, after a 10-day MPD withdrawal, the results showed a significant increase of [3H]-Dopamine uptake, of the quantity of [3H]-SCH 23390 binding sites and of cAMP levels in these animals. Finally, SHR that underwent a 10-day MPD withdrawal and were challenged with cocaine (10 mg/kg i.p. presented reduced [3H]-Dopamine uptake and increased cAMP production. Wistar rats were affected by the 10-day withdrawal of MPD in [3H]-dopamine uptake but not in cAMP accumulation; in addition, cocaine was unable to induce significant modifications in [3H]-dopamine uptake and in cAMP levels after the 10-day withdrawal of MPD. These results indicate a mechanism that could explain the high comorbidity between ADHD adolescent patients under methylphenidate treatment and substance abuse in adult

  13. Origins of Montessori Programming for Dementia.

    Science.gov (United States)

    Camp, Cameron J

    2010-01-01

    The focus of this article is on the evolution of the use of Montessori educational methods as the basis for creating interventions for persons with dementia. The account of this evolution is autobiographical, as the development of Montessori Programming for Dementia (MPD) initially was through the efforts of myself and my research associates. My initial exposure to Maria Montessori's work came as a result of my involvement with my own children's education. This exposure influenced ongoing research on development of cognitive interventions for persons with dementia. A brief description of Montessori's work with children and the educational methods she developed is followed by a description of how this approach can be translated into development of activities for persons with dementia. Assessment tools to document effects of MPD were created, focusing on observational tools to measure engagement and affect during individual and group activities programming for persons with dementia. Examples of the use of MPD by researchers, staff members, and family members are given, as well as examples of how persons with dementia can provide MPD to other persons with dementia or to children. Finally, examples of MPD's dissemination internationally and future directions for research are presented.

  14. Pathological consequences of chronic low daily dose gamma irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Seed, T.M.; Miller, A.C.; Ramakrishnan, N. [Armed Forces Radiobiology Research Inst., Bethesda, MD (United States); Fritz, T.E.

    2000-07-01

    The quantitative relationships between the chronic radiation exposure parameters of dose-rate and total dose in relation to associated health risks was examined in dogs. At a dose-rate of 75, 128, and 263 mGy/d the incidence of acute lymphohematopoietic suppression (aplastic anemia) and associated septic complications was 73%, 87%, and 100%, respectively, and it increased in dose-dependent manner. By contrast, at dose-rates below 75 mGy/d, late cancers contributed significantly to the death of relatively long-lived animals, whose mean survival time was 1800 days. Myeloproliferative disease (MPD), mainly myeloid leukemia, was the dominant pathology seen at the higher daily dose-rates (18.8-75 mGy/d). When daily exposure was carried out continuously, the incidence of MPD was quite high. It should be noted that the induction radiation-induced MPD in this study was highly significant, because spontaneous MPD is exceedingly rare in the dog. However, when the daily dose-rate was reduced further or exposure was discontinued, the incidence of MPD declined significantly. At these lower dose-rates, solid tumors contributed heavily to the life-shortening effects of chronic irradiation. The induction and progression of these survival-compromising, late forms of pathology appeared to be driven by the degree of hematopoietic suppression that occurred early during the exposure phase, and in turn by the capacity of hematopoietic system to repair itself, recover, and to accommodate under chronic radiation stress. (K.H.)

  15. The role of MRI in evaluation of acute pancreatitis

    International Nuclear Information System (INIS)

    Baba, Maiko; Munechika, Horotsugu

    2003-01-01

    The purpose of this study is to assess the role of MRI in acute pancreatitis. The findings of MPD (main pancreatic duct) and CBD (common bile duct) on MR cholangiopancreatography (MRCP) images were retrospectively reviewed in 60 patients with acute pancreatitis. The patients were divided into two groups; severe and mild pancreatitis, according to the criteria of Japanese group of investigation for pancreatic diseases. T2 weighed MR images were compared with contrast-enhanced CT images for evaluation of severity of the disease. MRCP images were also compared with endoscopic retrograde cholangiopancreatography (ERCP) images for evaluation of MPD and CBD. CBD was more clearly demonstrated by MRCP than MPD. Both MPD and CBD were more clearly seen in the mild group than in the severe group. A few false-negative cases were seen in MRCP. T2 weighed MR images were almost the same as contrast-enhanced CT images in diagnosis of acute pancreatitis. MRCP is useful for evaluation of CBD in severe cases and for evaluation of both CBD and MPD in mild cases of acute pancreatitis. The severity of disease can be evaluated by combination of T2 weighted MR images and MRCP alternative to contrast-enhanced CT. (author)

  16. Continuous treatment of N-Methyl-p-nitro aniline (MNA) in an Upflow Anaerobic Sludge Blanket (UASB) bioreactor

    Science.gov (United States)

    Olivares, Christopher I.; Wang, Junqin; Silva Luna, Carlos D.; Field, Jim A.; Abrell, Leif; Sierra-Alvarez, Reyes

    2017-01-01

    N-methyl-p-nitroaniline (MNA) is an ingredient of insensitive munitions (IM) compounds that serves as a plasticizer and helps reduce unwanted detonations. As its use becomes widespread, MNA waste streams will be generated, necessitating viable treatment options. We studied MNA biodegradation and its inhibition potential to, a representative anaerobic microbial population in wastewater treatment, methanogens. Anaerobic biodegradation and toxicity assays were performed and an up-flow anaerobic sludge blanket reactor (UASB) was operated to test continuous degradation of MNA. MNA was transformed almost stoichiometrically to N-methyl-p-phenylenediamine (MPD). MPD was not mineralized, however, it was readily autoxidized and polymerized extensively upon aeration at pH = 9. In the UASB reactor, MNA was fully degraded up to a loading rate of 297.5 μM MNA d-1). Regarding toxicity, MNA was very inhibitory to acetoclastic methanogens (IC50 = 103 μM) whereas MPD was much less toxic, causing only 13.9% inhibition at the highest concentration tested (1025 μM). The results taken as a whole indicate that anaerobic sludge can transform MNA to MPD continuously, and that the transformation decreases the cytotoxicity of the parent pollutant. MPD can be removed through extensive polymerization. These insights could help define efficient treatment options for waste streams polluted with MNA. PMID:26454121

  17. Specific Radiological Imaging Findings in Patients With Hereditary Pancreatitis During a Long Follow-up of Disease.

    Science.gov (United States)

    van Esch, Aura A J; Drenth, Joost P H; Hermans, John J

    2017-03-01

    Hereditary pancreatitis (HP) is characterized by recurrent episodes of inflammation of the pancreas. Radiological imaging is used to diagnose HP and to monitor complications. The aim of this study was to describe specific imaging findings in HP. We retrospectively collected data of HP patients with serial imaging and reviewed all radiological imaging studies (transabdominal ultrasonography, computed tomography, and magnetic resonance imaging). We included 15 HP patients, with a mean age of 32.5 years (range, 9-61 years) and mean disease duration of 24.1 years (range, 6-42 years). In total, 152 imaging studies were reviewed. Seventy-three percent of patients had a dilated main pancreatic duct (MPD) (width 3.5-18 mm). The MPD varied in size during disease course, with temporary reduction in diameter after drainage procedures. A severe dilated MPD (>10 mm) often coincided with presence of intraductal calcifications (size, 1-12 mm). In 73% of patients, pancreatic parenchyma atrophy occurred, which did not correlate with presence of exocrine or endocrine insufficiency. In HP, the MPD diameter increases with time, mostly without dilated side branches, and is often accompanied by large intraductal calcifications. The size of the MPD is independent of disease state. Atrophy of pancreatic parenchyma is not correlated with exocrine or endocrine insufficiency.

  18. Platelet size and density affect shear-induced thrombus formation in tortuous arterioles

    Science.gov (United States)

    Chesnutt, Jennifer K. W.; Han, Hai-Chao

    2013-10-01

    Thrombosis accounts for 80% of deaths in patients with diabetes mellitus. Diabetic patients demonstrate tortuous microvessels and larger than normal platelets. Large platelets are associated with increased platelet activation and thrombosis, but the physical effects of large platelets in the microscale processes of thrombus formation are not clear. Therefore, the objective of this study was to determine the physical effects of mean platelet volume (MPV), mean platelet density (MPD) and vessel tortuosity on platelet activation and thrombus formation in tortuous arterioles. A computational model of the transport, shear-induced activation, collision, adhesion and aggregation of individual platelets was used to simulate platelet interactions and thrombus formation in tortuous arterioles. Our results showed that an increase in MPV resulted in a larger number of activated platelets, though MPD and level of tortuosity made little difference on platelet activation. Platelets with normal MPD yielded the lowest amount of mural thrombus. With platelets of normal MPD, the amount of mural thrombus decreased with increasing level of tortuosity but did not have a simple monotonic relationship with MPV. The physical mechanisms associated with MPV, MPD and arteriole tortuosity play important roles in platelet activation and thrombus formation.

  19. Psychiatrists' attitudes to multiple personality disorder: a questionnaire study.

    Science.gov (United States)

    Mai, F M

    1995-04-01

    To assess the attitudes of a random sample of Canadian psychiatrists to Multiple Personality Disorder (MPD) and assess the relative prevalence of the condition in three comparable cities in Ontario. A questionnaire was sent to all psychiatrists who were members of the Canadian Psychiatric Association and who were resident in Ottawa, Kingston and London. Questions were asked on the respondent's personal clinical experience of MPD and his/her attitude to this condition. Some personal and demographic questions were also included. 180 out of 294 questionnaires (61.2%) were returned. The existence of MPD was doubted by 27.8% of psychiatrists who responded to the questionnaire, with a significantly higher proportion in London than in Kingston or in Ottawa. A substantial majority in all three cities agreed that media publicity and the psychiatrist's own belief system affected the prevalence of MPD. These results confirm that there is a split in the profession regarding belief in the existence of MPD as a diagnosis.

  20. Pulsed electromagnetic acceleration

    Science.gov (United States)

    Jahn, R. G.; Vonjaskowsky, W. F.; Clark, K. E.

    1973-01-01

    Direct measurements of the power deposited in the anode of a multimegawatt MPD accelerator using thermocouples attached to a thin shell anode reveal a dramatic decrease in the fractional anode power from 50% at 200 KW input power to less than 10% at 20 MW power. The corresponding local power flux peak at a value of 10,000 W/sq cm at the lip of the anode exhaust orifice, a distribution traced to a corresponding peak in the local current density at the anode. A comparison of voltage-current characteristics and spectral photographs of the MPD discharge using quartz, boron nitride and plexiglas insulators with various mass injection configurations led to the identification of different voltage modes and regions of ablation free operation. The technique of piezoelectric impact pressure measurement in the MPD exhaust flow was refined to account for the effects due to probe yaw angle.

  1. Pancreatic duct stenosis: Differential diagnosis between malignant and benign conditions at secretin-enhanced MRCP.

    Science.gov (United States)

    Boninsegna, Enrico; Manfredi, Riccardo; Negrelli, Riccardo; Avesani, Giacomo; Mehrabi, Sara; Pozzi Mucelli, Roberto

    To define imaging criteria of benign and malignant nature in patients with main pancreatic duct (MPD) stenosis. S-MRCPs of 35 patients with pancreatitis and 14 with adenocarcinoma were evaluated. Adenocarcinoma caused higher prevalence of complete stenosis (14/14-100% vs 17/35-49%), dilated side-branches (14/14-100% vs 18/35-51%) and lower prevalence of duct-penetrating sign (0/14-0% vs 31/35-89%). The number of stenoses was higher in benign conditions (mean 1.4 Vs 1). Upstream MPD diameter was higher in cancer-induced stenoses (4.5 vs 2.9mm). Single complete stenosis with dilated side branches, increased MPD caliber and absent duct-penetrating sign are suggestive of malignancy. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Association of serum total antioxidant capacity and total oxidant status with pain perception in patients with myofacial pain dysfunction.

    Science.gov (United States)

    Etoz, Osman A; Ataoglu, Hanife; Erel, Ozcan; Celik, Hakim; Herken, Emine Nur; Bayazit, Yildirim Ahmet

    2009-01-01

    We aimed to find out the association of total antioxidant capacity (TAC) and total oxidant status (TOS) with generalized pressure pain thresholds (PPT) of patients with myofacial pain dysfunction (MPD). PPT scores of patients with MPD (n = 37) and healthy individuals (n = 43) were measured on the hypothenar region of the hand using a mechanical algometer. Serum samples were collected and TAC and TOS were measured by novel methods. The TAC of patients was significantly lower than that of the control subjects. The difference between the TOS measurements of patients and control subjects was not significant. The PPT scores of the patients were significantly lower than that of control subjects. There may be an association between serum antioxidant capacity and MPD. Low serum TAC might also be related with pain perception.

  3. Work-related stress according to the demand-control model and minor psychic disorders in nursing workers

    Directory of Open Access Journals (Sweden)

    Janete de Souza Urbanetto

    2013-10-01

    Full Text Available This was a cross-sectional study that aimed to assess the association between work-related stress according to the Demand-Control Model, and the occurrence of Minor Psychic Disorder (MPD in nursing workers. The participants were 335 professionals, out of which 245 were nursing technicians, aged predominantly between 20 and 40 years. Data were collected using the Job Stress Scale and the Self-Reporting Questionnaire-20. The analysis was performed using descriptive and analytical statistics. The prevalence of suspected MPD was 20.6%. Workers classified in the quadrants active job and high strain of the Demand-Control Model presented higher potential for developing MPD compared with those classified in the quadrant low strain. In conclusion, stress affects the mental health of workers and the aspects related to high psychological demands and high control still require further insight in order to understand their influence on the disease processes of nursing workers.

  4. Microcephalic Osteodysplastic Primordial Dwarfism, Type II: a Clinical Review.

    Science.gov (United States)

    Bober, Michael B; Jackson, Andrew P

    2017-04-01

    This review will provide an overview of the microcephalic primordial dwarfism (MPD) class of disorders and provide the reader comprehensive clinical review with suggested care guidelines for patients with microcephalic osteodysplastic primordial dwarfism, type II (MOPDII). Over the last 15 years, significant strides have been made in the diagnosis, natural history, and management of MOPDII. MOPDII is the most common and well described form of MPD. The classic features of the MPD group are severe pre- and postnatal growth retardation, with marked microcephaly. In addition to these features, individuals with MOPDII have characteristic facies, skeletal dysplasia, abnormal dentition, and an increased risk for cerebrovascular disease and insulin resistance. Biallelic loss-of-function mutations in the pericentrin gene cause MOPDII, which is inherited in an autosomal recessive manner.

  5. Mesenteric venous thrombosis secondary to an unsuspected JAK2 V617F-positive myeloproliferative disorder.

    LENUS (Irish Health Repository)

    2012-01-31

    BACKGROUND: Mesenteric venous thrombosis (MVT) is a rare but potentially fatal cause of mesenteric ischaemia. It presents insidiously and often diagnosis is made at emergency surgery. In half of the cases MVT develops without a causative factor, while in cases in which a pro-thrombotic state is found to exist MVT may be the first clinically detected consequence of that state. The myeloproliferative disorders (MPD) are known to contribute to the development of pro-thrombotic states. Recently, the JAK2 V617F mutation has been associated with the MPDs. CONCLUSION: We describe a case of MVT occurring secondary to an unsuspected MPD, in which the patient was subsequently found to carry this mutation. We highlight the necessity to screen for this mutation in cases of intra-abdominal thromboses so that appropriate systemic anticoagulation may be instituted, and the patient may be followed so as to detect the development of an overt MPD.

  6. Essential thrombocythemia: Rare cause of chorea

    Directory of Open Access Journals (Sweden)

    Eswaradass Prasanna Venkatesan

    2014-01-01

    Full Text Available Essential thrombocythemia (ET is a clonal myeloproliferative disorder (MPD, characterized predominantly by a markedly elevated platelet count without known cause. It is rare hematological disorder. In ET clinical picture is dominated by a predisposition to vascular occlusive events and hemorrhages. Headache, transient ischemic attack, stroke, visual disturbances and light headedness are some of the neurological manifestations of ET. Here, we describe a 55 year-old female who presented to us with generalized chorea. On evaluation, she was found to have thrombocytosis. After ruling out the secondary causes of thrombocytosis and other MPD we confirmed diagnosis of ET in her by bone marrow studies. Polycythemia vera (PV another MPD closely related to ET may be present with generalized chorea. There are few case reports of PV presenting as chorea in the literature, but none with ET. We report the first case of ET presenting as generalized chorea.

  7. Methods to model-check parallel systems software

    International Nuclear Information System (INIS)

    Matlin, O. S.; McCune, W.; Lusk, E.

    2003-01-01

    We report on an effort to develop methodologies for formal verification of parts of the Multi-Purpose Daemon (MPD) parallel process management system. MPD is a distributed collection of communicating processes. While the individual components of the collection execute simple algorithms, their interaction leads to unexpected errors that are difficult to uncover by conventional means. Two verification approaches are discussed here: the standard model checking approach using the software model checker SPIN and the nonstandard use of a general-purpose first-order resolution-style theorem prover OTTER to conduct the traditional state space exploration. We compare modeling methodology and analyze performance and scalability of the two methods with respect to verification of MPD

  8. 8-MOP PUVA for psoriasis: a comparison of a minimal phototoxic dose-based regimen with a skin-type approach

    Energy Technology Data Exchange (ETDEWEB)

    Collins, P.; Wainwright, N.J.; Amorim, I.; Lakshmipathi, T.; Ferguson, J. [Ninewells Hospital and Medical School, Dundee (United Kingdom)

    1996-08-01

    Two ultraviolet A (UVA) regimens for oral 8-methoxypsoralen (8-MOP) photochemotherapy (PUVA) for moderate/severe chronic plaque psoriasis using a half-body study technique were compared. Each patient received both regimens. A higher-dose regimen based on minimal phototoxic dose (MPD) with percentage incremental increases was given to one-half of the body. The other half received a lower dose regimen based on skin type with fixed incremental UVA increases. Patients were treated twice weekly. Symmetrical plaques were scored to determine the rate of resolution with each regimen. In addition, the number of treatments, cumulative UVA dose and number of days in treatment to achieve overall clearance were recorded. Patients were reviewed monthly for one year to record remission data. Thirty-three patients completed the study. Both regimens were effective and well tolerated. With the MPD-based approach, number of exposures was significantly less for patients with skin types I and II but not III. Although the cumulative UVA dose was higher with the MPD regimen for all skin types studied, the reduced number of exposures required for clearance for skin types I and II but not III, combined with the security of individualized MPD testing, has practical attractions. MPD testing also identified five patients who required an increased psoralen dose and six patients who required a reduction of the initial UVA dose with the skin type regimen. Forty-two percent were still clear 1 year after treatment and there was no significant difference in the number of days in remission between the regimens for those whose psoriasis had recurred. The reduction in the number of exposures required for clearance with the MPD-based regimen may be safer and more cost effective in the long term. (author).

  9. Prediction of pathogen growth on iceberg lettuce under real temperature history during distribution from farm to table.

    Science.gov (United States)

    Koseki, Shigenobu; Isobe, Seiichiro

    2005-10-25

    The growth of pathogenic bacteria Escherichia coli O157:H7, Salmonella spp., and Listeria monocytogenes on iceberg lettuce under constant and fluctuating temperatures was modelled in order to estimate the microbial safety of this vegetable during distribution from the farm to the table. Firstly, we examined pathogen growth on lettuce at constant temperatures, ranging from 5 to 25 degrees C, and then we obtained the growth kinetic parameters (lag time, maximum growth rate (micro(max)), and maximum population density (MPD)) using the Baranyi primary growth model. The parameters were similar to those predicted by the pathogen modelling program (PMP), with the exception of MPD. The MPD of each pathogen on lettuce was 2-4 log(10) CFU/g lower than that predicted by PMP. Furthermore, the MPD of pathogens decreased with decreasing temperature. The relationship between mu(max) and temperature was linear in accordance with Ratkowsky secondary model as was the relationship between the MPD and temperature. Predictions of pathogen growth under fluctuating temperature used the Baranyi primary microbial growth model along with the Ratkowsky secondary model and MPD equation. The fluctuating temperature profile used in this study was the real temperature history measured during distribution from the field at harvesting to the retail store. Overall predictions for each pathogen agreed well with observed viable counts in most cases. The bias and root mean square error (RMSE) of the prediction were small. The prediction in which mu(max) was based on PMP showed a trend of overestimation relative to prediction based on lettuce. However, the prediction concerning E. coli O157:H7 and Salmonella spp. on lettuce greatly overestimated growth in the case of a temperature history starting relatively high, such as 25 degrees C for 5 h. In contrast, the overall prediction of L. monocytogenes under the same circumstances agreed with the observed data.

  10. Automated Kick Control Procedure for an Influx in Managed Pressure Drilling Operations

    Directory of Open Access Journals (Sweden)

    Jing Zhou

    2016-01-01

    Full Text Available Within drilling of oil and gas wells, the Managed Pressure Drilling (MPD method with active control of wellbore pressure during drilling has partly evolved from conventional well control procedures. However, for MPD operations the instrumentation is typically more extensive compared to conventional drilling. Despite this, any influx of formation fluids (commonly known as a kick during MPD operations is typically handled by conventional well control methods, at least if the kick is estimated to be larger than a threshold value. Conventional well control procedures rely on manual control of the blow out preventer, pumps, and choke valves and do not capitalize on the benefits from the instrumentation level associated with MPD. This paper investigates two alternative well control procedures specially adapted to backpressure MPD: the dynamic shut-in (DSI procedure and the automatic kick control (AKC procedure. Both methods capitalize on improvements in Pressure While Drilling (PWD technology. A commercially available PWD tool buffers high-resolution pressure measurements, which can be used in an automated well control procedure. By using backpressure MPD, the choke valve opening is tuned automatically using a feedback-feedforward control method. The two procedures are evaluated using a high fidelity well flow model and cases from a North Sea drilling operation are simulated. The results show that using AKC procedure reduces the time needed to establish control of the well compared to DSI procedure. It also indicates that the AKC procedure reduces the total kick size compared to the DSI procedure, and thereby reduces the risk of lost circulation.

  11. Soft versus hard occlusal splint therapy in the management of temporomandibular disorders (TMDs)

    OpenAIRE

    Seifeldin, Sameh A; Elhayes, Khaled A.

    2015-01-01

    Aim: To compare between soft and hard occlusal splint therapy for the management of myofacial pain dysfunction (MPD) or internal derangement (ID) of the temporomandibular joint (TMJ) with reciprocal clicking. Patients and methods: This study included 50 patients (age range: 24–47 years) who had been diagnosed with MPD or ID of the TMJ in the form of reciprocal clicking. Patients were divided into two groups. They were treated for 4 months with either a vacuum-formed soft occlusal splint co...

  12. Changing patterns of radiosensitivity of hematopoietic progenitors from chronically irradiated dogs prone either to aplastic anemia or to myeloproliferative disease

    International Nuclear Information System (INIS)

    Seed, T.M.; Kaspar, L.V.

    1990-01-01

    Hematopoietic patterns have been assessed in chronic 60 Co gamma irradiated dogs during preclinical phases of evolving aplastic anemia (AA) or myeloproliferative disease (MPD), principally myeloid leukemia. The results support the concept that acquired radioresistance of vital granulocyte/monocyte lineage-committed hematopoietic progenitors is temporally, perhaps causally, linked to the processes mediating hematopoietic recovery and accommodation under chronic irradiation, and in turn to preclinical events of evolving MPD. In addition, the marked differential responses of progenitors to gamma and neutron irradiation in vitro might suggest differences in the nature of cellular lesions elicited by chronic gamma irradiation, in vivo. (author)

  13. Changing patterns of radiosensitivity of hematopoietic progenitors from chronically irradiated dogs prone either to aplastic anemia or to myeloproliferative disease

    Energy Technology Data Exchange (ETDEWEB)

    Seed, T.M.; Kaspar, L.V. (Oak Ridge National Lab., TN (USA))

    1990-01-01

    Hematopoietic patterns have been assessed in chronic {sup 60}Co gamma irradiated dogs during preclinical phases of evolving aplastic anemia (AA) or myeloproliferative disease (MPD), principally myeloid leukemia. The results support the concept that acquired radioresistance of vital granulocyte/monocyte lineage-committed hematopoietic progenitors is temporally, perhaps causally, linked to the processes mediating hematopoietic recovery and accommodation under chronic irradiation, and in turn to preclinical events of evolving MPD. In addition, the marked differential responses of progenitors to gamma and neutron irradiation in vitro might suggest differences in the nature of cellular lesions elicited by chronic gamma irradiation, in vivo. (author).

  14. Roentgenographic observation of the myofascial pain dysfunction syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Hyung Kyu [Department of Radiology, College of Dentistry, Seoul National University, Seoul (Korea, Republic of)

    1975-11-15

    The author has observed 64 films from M.P.D. syndrome cases taken in Dept. of Oral Radiology, the Infirmary of Den tal College, Seoul National University in 1974, and obtained the following results: 1. In M.P.D. syndrome, the ratio between the female and the male were 2:1. 2. The prevalent age was aged 20,30,10, and 40 in decreasing order. 3. The incidence was 21.8% in the left side, 29% in the right, and 21% was bilaterally, which show the right most frequent. 4. The roentgenograms revealed variable findings in each case, but there were not recognized any significant differences.

  15. Roentgenographic observation of the myofascial pain dysfunction syndrome

    International Nuclear Information System (INIS)

    Ahn, Hyung Kyu

    1975-01-01

    The author has observed 64 films from M.P.D. syndrome cases taken in Dept. of Oral Radiology, the Infirmary of Den tal College, Seoul National University in 1974, and obtained the following results: 1. In M.P.D. syndrome, the ratio between the female and the male were 2:1. 2. The prevalent age was aged 20,30,10, and 40 in decreasing order. 3. The incidence was 21.8% in the left side, 29% in the right, and 21% was bilaterally, which show the right most frequent. 4. The roentgenograms revealed variable findings in each case, but there were not recognized any significant differences.

  16. Molecular system analysis, multidimensional, dynamic, ultra-sensitive exploration of proteomes

    International Nuclear Information System (INIS)

    Scharattenholz, A.; Soski, V.; Stegmann, W.; Schroer, K.; Godovac-Zimmermann, J.; Cabuk, A.; Pejovi, V.; Wozny, W.; Cahill, M.A.; Drukier, A.K.; Volkovitsky, P.

    2001-01-01

    ProteoSys AG's holistic proteomics strategy extends beyond classical proteome research as a new paradigm. Our concept of multidimensional molecular systems analysis of complex model systems employs the innovative ProteoDyn TM approach. This enables us to correlate dynamic changes of proteomes with their biophysical and biochemical environment. Our supersensitive Multi Photon Detection (MPD) technology enables ultra-sensitive detection of proteins, deep into the low abundance domain. Our technology platform includes the affinity analysis of phospho- and glyco-proteomes, and with our 'fish hook' methods we can capture and fully characterize even serpentine G-coupled receptors and associated proteins, including routine comprehensive post-translational analyses performed by a well equipped mass spectrometry group. Throughput and quality is obtained by automation and high end robotics, with data management handled by a dedicated bioinformatics department. Thus ProteoSys AG has a range of state of the art and proprietary tools at its disposal to analyse even the most difficult complex model systems. MPD is an isotopic detection method proprietary to ProteoSys For MPD analysis we have implemented protocols where over 99% of proteins can be iodinated, and where the iodinated proteins can be identified by mass spectrometry. Because MPD measures the energy of detected particles, it can discriminate between signals originating from different isotopes co-electrophoresed by 2D-PAGE. Thus MPD imagers have a 'multicolour' functionality suitable for differential display and improved throughput, eliminating inter-gel variations. Importantly, MPD opens up not only the world of detection of low abundance proteins, but also identification and characterization. Radioactive low abundance protein spots containing less than one attomole of protein can be excised from a 2D-gel, mixed with unlabelled proteins, and 'tracked' by MPD. The identity of the labeled protein is determined by

  17. Gain measurements of the Ca-Xe charge exchange system. [for UV lasers

    Science.gov (United States)

    Michels, C. J.; Chubb, D. L.

    1978-01-01

    Charge-exchange-pumped Ca(+) was studied for possible positive laser gain at 370.6 and 315.9 nm using an Xe MPD arc as the Xe(+) source. The present paper describes the MPD arc, the calcium injection system, the diagnostics for gain, and spontaneous emission measurements and results. No positive gain measurements were observed. A small Xe-Ca charge exchange cross section compared to He-metal laser systems charge exchange cross sections is the most probable reason why the result was negative.

  18. Assessment of a Revised Management Strategy for Patients With Intraductal Papillary Mucinous Neoplasms Involving the Main Pancreatic Duct.

    Science.gov (United States)

    Sugimoto, Motokazu; Elliott, Irmina A; Nguyen, Andrew H; Kim, Stephen; Muthusamy, V Raman; Watson, Rabindra; Hines, O Joe; Dawson, David W; Reber, Howard A; Donahue, Timothy R

    2017-01-18

    According to the 2012 International Consensus Guidelines, the diagnostic criterion of intraductal papillary mucinous neoplasms (IPMNs) involving the main duct (MD IPMNs) or the main and branch ducts (mixed IPMNs) of the pancreatic system is a main pancreatic duct (MPD) diameter of 5.0 mm or greater on computed tomography (CT) or magnetic resonance imaging (MRI). However, surgical resection is recommended for patients with an MPD diameter of 10.0 mm or greater, which is characterized as a high-risk stigma. An MPD diameter of 5.0 to 9.0 mm is not an indication for immediate resection. To determine an appropriate cutoff (ie, one with high sensitivity and negative predictive value) of the MPD diameter on CT or MRI as a prognostic factor for malignant disease and to propose a new management algorithm for patients with MD or mixed IPMNs. This retrospective cohort study included 103 patients who underwent surgical resection for a preoperative diagnosis of MD or mixed IPMN and in whom IPMN was confirmed by surgical pathologic findings at a single institution from July 1, 1996, to December 31, 2015. Malignant disease was defined as high-grade dysplasia or invasive adenocarcinoma on results of surgical pathologic evaluation. An appropriate MPD diameter on preoperative CT or MRI to predict malignant disease was determined using a receiver operating characteristic curve analysis. The prognostic value of the new management algorithm that incorporated the new MPD diameter cutoff was evaluated. Among the 103 patients undergoing resection for an MD or mixed IPMN (59 men [57.3%]; 44 women [42.7%]; median [range] age, 71 [48-86] years), 64 (62.1%) had malignant disease. Diagnostic accuracy for malignant neoplasms was highest at an MPD diameter cutoff of 7.2 mm (area under the receiver operating characteristic curve, 0.70; 95% CI, 0.59-0.81). An MPD diameter of 7.2 mm or greater was also an independent prognostic factor for malignant neoplasms (odds ratio, 12.76; 95% CI, 2

  19. ASME method for particle reconstruction

    International Nuclear Information System (INIS)

    Ierusalimov, A.P.

    2009-01-01

    The method of approximate solution of motion equation (ASME) was used to reconstruct the parameters for charged particles. It provides a good precision for momentum, angular and space parameters of particles in coordinate detectors. The application of the method for CBM, HADES and MPD/NICA setups is discussed

  20. K-RasV14I recapitulates Noonan syndrome in mice

    Science.gov (United States)

    Hernández-Porras, Isabel; Fabbiano, Salvatore; Schuhmacher, Alberto J.; Aicher, Alexandra; Cañamero, Marta; Cámara, Juan Antonio; Cussó, Lorena; Desco, Manuel; Heeschen, Christopher; Mulero, Francisca; Bustelo, Xosé R.; Guerra, Carmen; Barbacid, Mariano

    2014-01-01

    Noonan syndrome (NS) is an autosomal dominant genetic disorder characterized by short stature, craniofacial dysmorphism, and congenital heart defects. NS also is associated with a risk for developing myeloproliferative disorders (MPD), including juvenile myelomonocytic leukemia (JMML). Mutations responsible for NS occur in at least 11 different loci including KRAS. Here we describe a mouse model for NS induced by K-RasV14I, a recurrent KRAS mutation in NS patients. K-RasV14I–mutant mice displayed multiple NS-associated developmental defects such as growth delay, craniofacial dysmorphia, cardiac defects, and hematologic abnormalities including a severe form of MPD that resembles human JMML. Homozygous animals had perinatal lethality whose penetrance varied with genetic background. Exposure of pregnant mothers to a MEK inhibitor rescued perinatal lethality and prevented craniofacial dysmorphia and cardiac defects. However, Mek inhibition was not sufficient to correct these defects when mice were treated after weaning. Interestingly, Mek inhibition did not correct the neoplastic MPD characteristic of these mutant mice, regardless of the timing at which the mice were treated, thus suggesting that MPD is driven by additional signaling pathways. These genetically engineered K-RasV14I–mutant mice offer an experimental tool for studying the molecular mechanisms underlying the clinical manifestations of NS. Perhaps more importantly, they should be useful as a preclinical model to test new therapies aimed at preventing or ameliorating those deficits associated with this syndrome. PMID:25359213

  1. A Thin Film Nanocomposite Membrane with MCM-41 Silica Nanoparticles for Brackish Water Purification

    Directory of Open Access Journals (Sweden)

    Mohammed Kadhom

    2016-12-01

    Full Text Available Thin film nanocomposite (TFN membranes containing MCM-41 silica nanoparticles (NPs were synthesized by the interfacial polymerization (IP process. An m-phenylenediamine (MPD aqueous solution and an organic phase with trimesoyl chloride (TMC dissolved in isooctane were used in the IP reaction, occurring on a nanoporous polysulfone (PSU support layer. Isooctane was introduced as the organic solvent for TMC in this work due to its intermediate boiling point. MCM-41 silica NPs were loaded in MPD and TMC solutions in separate experiments, in a concentration range from 0 to 0.04 wt %, and the membrane performance was assessed and compared based on salt rejection and water flux. The prepared membranes were characterized via scanning electron microscopy (SEM, transmission electron microscopy (TEM, contact angle measurement, and attenuated total reflection Fourier transform infrared (ATR FT-IR analysis. The results show that adding MCM-41 silica NPs into an MPD solution yields slightly improved and more stable results than adding them to a TMC solution. With 0.02% MCM-41 silica NPs in the MPD solution, the water flux was increased from 44.0 to 64.1 L/m2·h, while the rejection virtually remained the same at 95% (2000 ppm NaCl saline solution, 25 °C, 2068 kPa (300 psi.

  2. Blood responses under chronic low daily dose gamma irradiation: Pt. 2; Differential preclinical responses of irradiated female dogs in progression to either aplastic anemia or myeloproliferative disease

    Energy Technology Data Exchange (ETDEWEB)

    Seed, T.; Carnes, B.; Tolle, D.; Fritz, T. (Argonne National Lab., IL (United States). Biological and Medical Research Div.)

    1993-05-01

    Female beagle dogs were chronically exposed to low daily doses of [sup 60]Co gamma rays and responded in one of three distinct hemopathological patterns. These patterns, reflective of distinct subgroups, were characterized by (a) low radioresistance resulting in progressive hematopoietic suppression, terminal aplastic anemia (AA), and relatively short (<400 days) survival ([sup -]S-AA subgroups); (b) high radioresistance, initially coupled with strong but aberrant regenerative hematopoiesis, and later with the development of myeloproliferative disease (MPD) ([sup +]-R-MPD subgroup); and (c) high radioresistance, coupled with an early phase of strong regenerative hematopoiesis, but later with no myeloproliferative disease ([sup +]R-nonMPD subgroup). In this study, the changes in circulating blood cells levels (granulocytes, monotcytes, erythrocytes, lymphocytes and platelets) were sequentially assessed in time and fitted to a flexible, quadratic-linear-type response model previously developed. The results are consistent with our earlier observations of blood responses of chronically irradiated male dogs, in the subgroups of female dogs prone to specific radiogenic hematopathologies (i.e. AA and MPD) can be readily identified and staged in specific preclinical periods by a series of marked differential blood responses. (Author).

  3. Functional eladic containing triglycerides: Synthesis, physical properties, and solution behavior

    Science.gov (United States)

    The enthalpy of fusion (Hf) for a number of symmetrical and asymmetrical triacylgylcerides as mixtures in soybean oil (TAGs) were determined by melting point data (MPD), differential scanning calorimetry (DSC), and effective carbon numbers (ECN). Pure triacylgylcerides were mixed with soybean oil an...

  4. 75 FR 1536 - Airworthiness Directives; The Boeing Company Model 737-600, -700, and -800 Series Airplanes

    Science.gov (United States)

    2010-01-12

    ... alteration, design change, or repair involving new penetrations of the fuel tanks (such as a repair with... structure is affected, while the structural repair does not disrupt the fuel tank system. CAL states that it... instructions require installing fasteners into the fuel tank. CAL notes that FAA approval of the MPD AWLs can...

  5. Avocado Consumption Increases Macular Pigment Density in Older Adults: A Randomized, Controlled Trial

    Directory of Open Access Journals (Sweden)

    Tammy M. Scott

    2017-08-01

    Full Text Available Lutein is selectively incorporated into the macula and brain. Lutein levels in the macula (macular pigment; MP and the brain are related to better cognition. MP density (MPD is a biomarker of brain lutein. Avocados are a bioavailable source of lutein. This study tests the effects of the intake of avocado on cognition. This was a six-month, randomized, controlled trial. Healthy subjects consumed one avocado (n = 20, 0.5 mg/day lutein, AV vs. one potato or one cup of chickpeas (n = 20, 0 mg/day lutein, C. Serum lutein, MPD, and cognition were assessed at zero, three, and six months. Primary analyses were conducted according to intent-to-treat principles, with repeated-measures analysis. At six months, AV increased serum lutein levels by 25% from baseline (p = 0.001. C increased by 15% (p = 0.030. At six months, there was an increase in MPD from baseline in AV (p = 0.001 and no increase in C. For both groups, there was an improvement in memory and spatial working memory (p = 0.001; p = 0.032, respectively. For AV only there was improved sustained attention (p = 0.033, and the MPD increase was related to improved working memory and efficiency in approaching a problem (p = 0.036. Dietary recommendations including avocados may be an effective strategy for cognitive health.

  6. Computing the Expected Value and Variance of Geometric Measures

    DEFF Research Database (Denmark)

    Staals, Frank; Tsirogiannis, Constantinos

    2017-01-01

    distance (MPD), the squared Euclidean distance from the centroid, and the diameter of the minimum enclosing disk. We also describe an efficient (1-e)-approximation algorithm for computing the mean and variance of the mean pairwise distance. We implemented three of our algorithms and we show that our...

  7. [Expression of JAK2V617F and MPLW515L/K mutation in 30 suspected cases of early myeloproliferative disorders].

    Science.gov (United States)

    Fan, Zheng; Zhang, Ri; Shen, Yi-Min; Fei, Hai-Rong; Zhu, Zi-Ling; Cen, Jian-Nong

    2008-09-01

    To investigate the prevalence of JAK2V617F and MPLW515L/K mutation in patients with slightly elevated platelets (BPC) or hemoglobin (Hb) not meeting the criteria of polycythemia vera (PV) or essential thrombocythemia (ET). Genomic DNA from bone marrow or blood mononuclear cells was screened with allele specific polymerase chain reaction (AS-PCR) for JAK2V617F and MPLW515L/K mutation. The history of thrombosis was assessed retrospectively by patients files. Of 30 patients, 14 (46.7%) were positive for the JAK2V617F mutation, none of them had the MPLW515L/ K. Five of these 14 patients had a history of thrombosis. Follow-up results were available in 22 patients. Among them, 12 patients with JAK2V617F mutation turned out to be MPD in 6-24 months; only 2 out of 10 patients without this mutation evolved to MPD. JAK2V617F mutation could be one of the diagnosis criteria of early MPD. No MPLW515L/K expression was found in early MPD.

  8. Multiquanta photodetachment from the H- ion

    International Nuclear Information System (INIS)

    Tang, Chen-Yau.

    1992-03-01

    Multiphoton detachment (MPD) of an electron from the loosely bound H - system (binding energy = 0.7542 eV) has been studied at various photon energies and laser intensities. In the center of mass of 800-MeV H - ions the CO 2 laser photon energy, 0.117 eV, was Doppler tuned over a wide range, from 0.15 to 0.39 eV. The peak laser intensity in the lab frame was varied from 2 to 12 GW/cm 2 . The general behavior of MPD versus photon energy and the ac-Stark/pondermotive effects are of special interest in the study. Characteristic threshold structures by absorption of 2, 3, 4, and 5 photons were observed, as evidenced by rapid changes in the signal amplitudes. These thresholds provide a straightforward picture of channel opening in MPD as the photon energy is increased. A fit of two-photon detachment data to the Wigner threshold law showed a good match with a small intensity-induced shift in the threshold energy. A study of laser intensity effects demonstrated departures from the simple power law predicted by lowest-order perturbation theory, which is possibly another indication of pondermotive shifts in the threshold. The absolute MPD rates have been estimated and found to be in fairly good agreement with the results of Floquet theory

  9. The role of multi-detector-row computed tomograph in the diagnosis of intraductal papillary-mucinous tumors of the pancreas in comparison to endoscopic retrograde pancreatography, endoscopic ultrasonography, magnetic resonance cholangiopancreatography

    International Nuclear Information System (INIS)

    Arikawa, Shunji; Uchida, Masafumi; Shinagawa, Masaharu

    2007-01-01

    Thirty patients with intraductal papillary-mucinous tumor (IPMT) of the pancreas underwent multidetector-row CT (MD-CT) in addition to endoscopic retrograde pancreatography (ERP), and, in 27 cases magnetic resonance cholangiopancreatography (MRCP) and endoscopic ultrasonography (EUS). The usefulness of MD-CT was investigated by comparing various imaging methods of the communication from the main pancreatic duct (MPD) to patulous/bulging papilla in addition to the indices for benign or malignant disease, the degree of dilation of the MPD, localization and size of cystic lesions, and presence or absence of neoplastic lesions, such as thickened walls and septa, intramural nodule, solid mass. With MD-CT, dilation of the MPD and localization and size of cystic lesions were accurately assessed, even in patients with obstruction of the main pancreatic duct in whom ERP was difficult to perform regardless of the presence or absence of massive amount of mucus. MD-CT with reconstructive imaging, such as multiplanar reformation (MPR) imaging and curred planar reformation (CPR) imaging, allowed us to assess communication with the MPD and patulous/bulging papilla easier than MRCP. In our study, MD-CT was useful in the evaluation of thickened walls and septa that are predictive factors of malignancy in IPMT. (author)

  10. Implikasi Hukum Terkait Pertimbangan Majelis Pendidikan Daerah dalam Penyelenggaraan Pemerintahan Aceh

    Directory of Open Access Journals (Sweden)

    Cut Meutia

    2017-04-01

    The Implementation of Duty and Function of The Province Education Board in the Aceh Governance ABSTRACT: Article 1 (6 of Qanun Number 3, 2006 on the Organization Arrangement and the Organization Structure and Working Structure of the MPD states that the as one of the governmental organization delaing with the education matters in Aceh  providing the policy and consideration for government in regard with the education policy. This research aims to explore the extent of the role of theProvince Education Board in developing the education and the legal consequence of not using the advise, consideration, and suggestions of the body by the Government of Aceh. This is descriptive analytical research by analyzing the data qualitativelyThe research shows that the MPD role has not been well conducted as the Government of Aceh is only wait the advise, consideration, and suggestion of the MPD and the Government of Aceh has no obligation to conduct them. The legal consequences of the Government of Aceh dose not impose them in the policy made, is there is no sanction for both executive and legislative parties due to disobeying the advice, consideration and suggestion of the MPD.

  11. Biometric authentication for a mobile personal device

    NARCIS (Netherlands)

    Tao, Q.; Veldhuis, Raymond N.J.

    2006-01-01

    Secure access is prerequisite for a mobile personal device (MPD) in a personal network (PN). An authentication method using biometrics, specifically face, is proposed in this paper. A fast face detection and registration method based on a Viola-Jones detector is implemented, and a

  12. Increased Milk Protein Concentration in a Rehydration Drink Enhances Fluid Retention Caused by Water Reabsorption in Rats.

    Science.gov (United States)

    Ito, Kentaro; Saito, Yuri; Ashida, Kinya; Yamaji, Taketo; Itoh, Hiroyuki; Oda, Munehiro

    2015-01-01

    A fluid-retention effect is required for beverages that are designed to prevent dehydration. That is, fluid absorbed from the intestines should not be excreted quickly; long-term retention is desirable. Here, we focused on the effect of milk protein on fluid retention, and propose a new effective oral rehydration method that can be used daily for preventing dehydration. We first evaluated the effects of different concentrations of milk protein on fluid retention by measuring the urinary volumes of rats fed fluid containing milk protein at concentrations of 1, 5, and 10%. We next compared the fluid-retention effect of milk protein-enriched drink (MPD) with those of distilled water (DW) and a sports drink (SD) by the same method. Third, to investigate the mechanism of fluid retention, we measured plasma insulin changes in rats after ingesting these three drinks. We found that the addition of milk protein at 5 or 10% reduced urinary volume in a dose-dependent manner. Ingestion of the MPD containing 4.6% milk protein resulted in lower urinary volumes than DW and SD. MPD also showed a higher water reabsorption rate in the kidneys and higher concentrations of plasma insulin than DW and SD. These results suggest that increasing milk protein concentration in a beverage enhances fluid retention, which may allow the possibility to develop rehydration beverages that are more effective than SDs. In addition, insulin-modifying renal water reabsorption may contribute to the fluid-retention effect of MPD.

  13. Advanced Solar-propelled Cargo Spacecraft for Mars Missions

    Science.gov (United States)

    Auziasdeturenne, Jacqueline; Beall, Mark; Burianek, Joseph; Cinniger, Anna; Dunmire, Barbrina; Haberman, Eric; Iwamoto, James; Johnson, Stephen; Mccracken, Shawn; Miller, Melanie

    1989-01-01

    Three concepts for an unmanned, solar powered, cargo spacecraft for Mars support missions were investigated. These spacecraft are designed to carry a 50,000 kg payload from a low Earth orbit to a low Mars orbit. Each design uses a distinctly different propulsion system: A Solar Radiation Absorption (SRA) system, a Solar-Pumped Laser (SPL) system and a solar powered magnetoplasmadynamic (MPD) arc system. The SRA directly converts solar energy to thermal energy in the propellant through a novel process. In the SPL system, a pair of solar-pumped, multi-megawatt, CO2 lasers in sunsynchronous Earth orbit converts solar energy to laser energy. The MPD system used indium phosphide solar cells to convert sunlight to electricity, which powers the propulsion system. Various orbital transfer options are examined for these concepts. In the SRA system, the mother ship transfers the payload into a very high Earth orbit and a small auxiliary propulsion system boosts the payload into a Hohmann transfer to Mars. The SPL spacecraft and the SPL powered spacecraft return to Earth for subsequent missions. The MPD propelled spacecraft, however, remains at Mars as an orbiting space station. A patched conic approximation was used to determine a heliocentric interplanetary transfer orbit for the MPD propelled spacecraft. All three solar-powered spacecraft use an aerobrake procedure to place the payload into a low Mars parking orbit. The payload delivery times range from 160 days to 873 days (2.39 years).

  14. Differentiation between autoimmune pancreatitis and pancreatic carcinoma based on endoscopic retrograde cholangiopancreatography findings

    International Nuclear Information System (INIS)

    Nishino, Takayoshi; Oyama, Hiroyasu; Shiratori, Keiko; Toki, Fumitake

    2010-01-01

    We have reviewed the endoscopic retrograde cholangiopancreatography (ERCP) images of patients with autoimmune pancreatitis (AIP) and pancreatic carcinoma (Pca) in an attempt to identify findings that would facilitate making a differential diagnosis between AIP and Pca. The study cohort consisted of 39 patients diagnosed with AIP and 62 patients diagnosed with Pca. The ERCP findings in the pancreatic duct and biliary tract were compared between the two groups. The ERCP images revealed that AIP patients had a higher prevalence of narrowing of the main pancreatic duct (MPD) for ≥3 cm of its length and a higher prevalence for the presence of side branches in the narrowed portion of the MPD than Pca patients (p 5 cm of its length and the presence of side branches. Among our patient cohort, the ERCP findings in terms of the length of the narrowed portion of the MPD, the presence of side branches, and maximal diameter of the upstream MPD enabled differential diagnosis between AIP and Pca in most of the cases. However, it must be borne in mind that some Pca patients have ERCP findings similar to those of AIP patients. (author)

  15. Isolation and characterization of novel hydrocarbon-degrading euryhaline consortia from crude oil and mangrove sediments.

    Science.gov (United States)

    Piedad Díaz, M; Grigson, S J; Peppiatt, C J; Burgess, J G

    2000-11-01

    Two novel and versatile bacterial consortia were developed for the biodegradation of hydrocarbons. They were isolated from crude oil from the Cormorant Field in the North Sea (MPD-7) and from sediment associated with mangrove roots (MPD-M). The bacterial consortia were able to degrade both aliphatic and aromatic hydrocarbons in crude oils very effectively in seawater (35 g/L NaCl) and synthetic media containing 0 to 100 g/L NaCl (1.7 M). Salinities over twice that of normal seawater decreased the biodegradation rates. However, even at the highest salinity biodegradation was significant. Ratios of nC17 to pristane and nC18 to phytane were significantly lowered across the range of salinity. The lowest values were at 0 and 20 g/L (0.34 M). Phytane was degraded in preference to pristane. The degradation of these compounds was constant over the salinity range, with evidence of a slight increase for consortium MPD-M with increasing salinity. In general, the consortium isolated from mangrove root sediments was more efficient in metabolizing North Sea crude oil than the consortium isolated from Cormorant crude oil. The 5 strains that comprise MPD-M have been tentatively identified as species of the genera Marinobacter, Bacillus, and Erwinia. This is the first report of hydrocarbon-degrading consortia isolated from crude oil and mangrove sediments that are capable of treating oily wastes over such a wide range of salinity.

  16. A Thin Film Nanocomposite Membrane with MCM-41 Silica Nanoparticles for Brackish Water Purification.

    Science.gov (United States)

    Kadhom, Mohammed; Yin, Jun; Deng, Baolin

    2016-12-06

    Thin film nanocomposite (TFN) membranes containing MCM-41 silica nanoparticles (NPs) were synthesized by the interfacial polymerization (IP) process. An m -phenylenediamine (MPD) aqueous solution and an organic phase with trimesoyl chloride (TMC) dissolved in isooctane were used in the IP reaction, occurring on a nanoporous polysulfone (PSU) support layer. Isooctane was introduced as the organic solvent for TMC in this work due to its intermediate boiling point. MCM-41 silica NPs were loaded in MPD and TMC solutions in separate experiments, in a concentration range from 0 to 0.04 wt %, and the membrane performance was assessed and compared based on salt rejection and water flux. The prepared membranes were characterized via scanning electron microscopy (SEM), transmission electron microscopy (TEM), contact angle measurement, and attenuated total reflection Fourier transform infrared (ATR FT-IR) analysis. The results show that adding MCM-41 silica NPs into an MPD solution yields slightly improved and more stable results than adding them to a TMC solution. With 0.02% MCM-41 silica NPs in the MPD solution, the water flux was increased from 44.0 to 64.1 L/m²·h, while the rejection virtually remained the same at 95% (2000 ppm NaCl saline solution, 25 °C, 2068 kPa (300 psi)).

  17. Analyses of critical target cell responses during preclinical phases of evolving chronic radiation-induced myeloproliferative disease-exploitation of a unique canine model

    International Nuclear Information System (INIS)

    Seed, T.M.; Kaspar, L.V.; Tolle, D.V.; Fritz, T.E.; Frazier, M.E.

    1988-01-01

    This document briefly summarizes and highlights ongoing studies on the cellular and molecular processes involved in the induction and progression of myeloid leukemia in dogs chronically exposed to low daily doses of wholebody gamma irradiation. Under such conditions, select groups of dogs exhibit extremely high frequencies of myeloproliferative disease (MPD) (i.e., /congruent/50%) of which myeloid leukemia is most prominent. 2 figs

  18. Analyses of critical target cell responses during preclinical phases of evolving chronic radiation-induced myeloproliferative disease-exploitation of a unique canine model

    Energy Technology Data Exchange (ETDEWEB)

    Seed, T.M.; Kaspar, L.V.; Tolle, D.V.; Fritz, T.E.; Frazier, M.E.

    1988-01-01

    This document briefly summarizes and highlights ongoing studies on the cellular and molecular processes involved in the induction and progression of myeloid leukemia in dogs chronically exposed to low daily doses of wholebody gamma irradiation. Under such conditions, select groups of dogs exhibit extremely high frequencies of myeloproliferative disease (MPD) (i.e., /congruent/50%) of which myeloid leukemia is most prominent. 2 figs.

  19. Diagnostic value of curved multiplanar reformatted images in multislice CT for the detection of resectable pancreatic ductal adenocarcinoma

    International Nuclear Information System (INIS)

    Fukushima, Hiromichi; Takada, Akira; Mori, Yoshimi; Suzuki, Kojiro; Sawaki, Akiko; Iwano, Shingo; Satake, Hiroko; Ota, Toyohiro; Ishigaki, Takeo; Itoh, Shigeki; Ikeda, Mitsuru

    2006-01-01

    The purpose of this study was to assess the usefulness of curved multiplanar reformatted (MPR) images obtained by multislice CT for the depiction of the main pancreatic duct (MPD) and detection of resectable pancreatic ductal adenocarcinoma. This study included 28 patients with pancreatic carcinoma (size range 12-40 mm) and 22 without. Curved MPR images with 0.5-mm continuous slices were generated along the long axis of the pancreas from pancreatic-phase images with a 0.5- or 1-mm slice thickness. Seven blinded readers independently interpreted three sets of images (axial images, curved MPR images, and both axial and curved MPR images) in scrolling mode. The depiction of the MPD and the diagnostic performance for the detection of carcinoma were statistically compared among these images. MPR images were significantly superior to axial images in depicting the MPD, and the use of both axial and MPR images resulted in further significant improvements. For the detection of carcinoma, MPR images were equivalent to axial images, and the diagnostic performance was significantly improved by the use of both axial and MPR images. High-resolution curved MPR images can improve the depiction of the MPD and the diagnostic performance for the detection of carcinoma compared with axial images alone. (orig.)

  20. Alterity: Learning Polyvalent Selves, Resisting Disabling Notions of the Self

    Science.gov (United States)

    Walker, Wayland

    2011-01-01

    This article queries how one type of human difference--alterity, the experience of multiple distinct consciousnesses, or "alters," by one person--is pathologized in American culture. This experience is inscribed as a mental illness, labeled now as dissociative identity disorder (DID) and formerly known as multiple personality disorder (MPD). In…

  1. Early Indicators of Pathological Dissociation in Sexually Abused Children.

    Science.gov (United States)

    McElroy, Linda Provus

    1992-01-01

    This paper reviews factors in the professional neglect of multiple personality disorder (MPD) and sexual abuse in childhood, as well as recent diagnostic developments in childhood dissociative disorders. The identification of subtle dissociative symptomatology in children is illustrated, and two case examples are presented. (Author)

  2. Dissociative Identity Disorder

    Science.gov (United States)

    Schmidt, Tom

    2007-01-01

    Few psychological disorders in the Diagnostic Statistical Manual have generated as much controversy as Dissociative Identity Disorder (DID). For the past 35 years diagnoses of DID, previously referred to as Multiple Personality Disorder (MPD), have increased exponentially, causing various psychological researchers and clinicians to question the…

  3. 76 FR 33176 - Airworthiness Directives; Airbus Model A300 B4-103, B4-203, and B4-2C Airplanes

    Science.gov (United States)

    2011-06-08

    ... Document (MPD) task 321112-0505-1) has been revised to introduce a greasing action at the level of the pick... with the new basic requirements of this proposed AD. The average labor rate is $85 per work-hour. Based... Government and the States, or on the distribution of power and responsibilities among the various levels of...

  4. Many-body processes in atomic and molecular physics. Progress report, September 1, 1983-August 31, 1984

    International Nuclear Information System (INIS)

    Chu, S.I.

    1984-02-01

    Research is reported on: semiclassical many mode Floquet theory; exact semiclassical treatment of nonlinear multiphoton dissociation; nonadiabatic approach for resonant infrared multiphoton absorption spectroscopy; infrared MPD of triatomic molecules, most probable path approach; and complex-coordinate coupled-Landau-channel method for autoionizing resonances of H atoms in intense magnetic fields

  5. Intraductal papillary mucinous neoplasms of the pancreas: Correlation of helical CT features with pathologic findings

    International Nuclear Information System (INIS)

    Liu Yu; Lin Xiaozhu; Upadhyaya, Manavendra; Song Qi; Chen Kemin

    2010-01-01

    Objective: To evaluate the CT features of intraductal papillary mucinous neoplasms of the pancreas (IPMNs), and to compare with pathological findings in order to identify CT features that can be helpful in differentiating benign IPMNs from malignant IPMNs. Materials and methods: The CT findings in 25 patients were reviewed for tumor location, tumor type, dilatation of the main pancreatic duct (MPD), MPD involvement, mural node or solid attenuating component, tumor size in branch duct or mixed duct type, dilatation of common bile duct (CBD) and invasion of surrounding structures. The data was subjected to Chi-Square Tests or Fisher's Exact Test using SPSS13.0 software with p value < 0.05 indicating significant statistical difference. Results: Presence of mural node or solid enhancing component, size of mural node or solid enhancing component ≥7 mm, dilatation of CBD was more common in malignant IPMNs (p < 0.05). None of tumor location, tumor type, dilatation of MPD, MPD involvement, tumor size, and invasion of surrounding structures was statistically significant in differentiating benign from malignant IPMNs. Conclusions: CT features suggestive of malignant or invasive IPMNs include presence of mural node or solid enhancing component, size of mural node or solid enhancing component ≥7 mm, and dilatation of CBD.

  6. Acoustics of the piezo-electric pressure probe

    Science.gov (United States)

    Dutt, G. S.

    1974-01-01

    Acoustical properties of a piezoelectric device are reported for measuring the pressure in the plasma flow from an MPD arc. A description and analysis of the acoustical behavior in a piezoelectric probe is presented for impedance matching and damping. The experimental results are presented in a set of oscillographic records.

  7. Prevalence of Janus kinase 2 mutations in patients with unusual site venous thrombosis

    Directory of Open Access Journals (Sweden)

    Ana Lisa Basquiera

    2011-08-01

    Full Text Available We aimed to study patients with splanchnic vein thrombosis (SVT and cerebral vein thrombosis (CVT searching for JAK2 mutations. We evaluated 14 patients (median age: 41.5 years with portal vein thrombosis (PVT = 7; mesenteric vein thrombosis (MVT = 3; and CVT = 4. JAK2 V617F was assessed by allele specific PCR of peripheral blood DNA. In addition, DNA was sequenced for other JAK2 mutations. Other inherited and acquired thrombophilia risk factors were evaluated. JAK2 V617F was positive in four out of seven patients with PVT and in one CVT patient. These five patients had a diagnosis of myeloproliferative disorder (MPD at the moment of the occurrence of thrombosis (n = 2 or later (n = 2. Patients with MVT and CVT were negative for JAK2 V617F, except one patient with CVT and a diagnosis of essential thrombocythemia. No other JAK2 mutations were found in this cohort. Besides MPD, other thrombophilia risk factors were identified in five patients. One patient had MPD as well as thrombophilia risk factor. In this group, 4 out of 7 of the patients with PVT carried the JAK2 V617F mutation with or without overt MPD. However, the investigation of other JAK2 mutations may not be necessary in patients with thrombosis at unusual sites.

  8. Avocado Consumption Increases Macular Pigment Density in Older Adults: A Randomized, Controlled Trial.

    Science.gov (United States)

    Scott, Tammy M; Rasmussen, Helen M; Chen, Oliver; Johnson, Elizabeth J

    2017-08-23

    Lutein is selectively incorporated into the macula and brain. Lutein levels in the macula (macular pigment; MP) and the brain are related to better cognition. MP density (MPD) is a biomarker of brain lutein. Avocados are a bioavailable source of lutein. This study tests the effects of the intake of avocado on cognition. This was a six-month, randomized, controlled trial. Healthy subjects consumed one avocado ( n = 20, 0.5 mg/day lutein, AV) vs. one potato or one cup of chickpeas ( n = 20, 0 mg/day lutein, C). Serum lutein, MPD, and cognition were assessed at zero, three, and six months. Primary analyses were conducted according to intent-to-treat principles, with repeated-measures analysis. At six months, AV increased serum lutein levels by 25% from baseline ( p = 0.001). C increased by 15% ( p = 0.030). At six months, there was an increase in MPD from baseline in AV ( p = 0.001) and no increase in C. For both groups, there was an improvement in memory and spatial working memory ( p = 0.001; p = 0.032, respectively). For AV only there was improved sustained attention ( p = 0.033), and the MPD increase was related to improved working memory and efficiency in approaching a problem ( p = 0.036). Dietary recommendations including avocados may be an effective strategy for cognitive health.

  9. GEOCHEMICAL ASSESSMENT OF SEDIMENT IN CAPE TOWN ...

    African Journals Online (AJOL)

    Preferred Customer

    Both the water and sediment samples at this site are very muddy ... a Phillip PANnalytical PW 3830/40 X-ray generator with a PW 3710 MPD control. X-ray ..... Shuping, L.S.; Snyman, R.G.; Odendaal, J.P.; Ndakidemi, P.A. Water Air Soil Pollut.

  10. Auditory-Motor Interactions in Pediatric Motor Speech Disorders: Neurocomputational Modeling of Disordered Development

    Science.gov (United States)

    Terband, H.; Maassen, B.; Guenther, F.H.; Brumberg, J.

    2014-01-01

    Background/Purpose Differentiating the symptom complex due to phonological-level disorders, speech delay and pediatric motor speech disorders is a controversial issue in the field of pediatric speech and language pathology. The present study investigated the developmental interaction between neurological deficits in auditory and motor processes using computational modeling with the DIVA model. Method In a series of computer simulations, we investigated the effect of a motor processing deficit alone (MPD), and the effect of a motor processing deficit in combination with an auditory processing deficit (MPD+APD) on the trajectory and endpoint of speech motor development in the DIVA model. Results Simulation results showed that a motor programming deficit predominantly leads to deterioration on the phonological level (phonemic mappings) when auditory self-monitoring is intact, and on the systemic level (systemic mapping) if auditory self-monitoring is impaired. Conclusions These findings suggest a close relation between quality of auditory self-monitoring and the involvement of phonological vs. motor processes in children with pediatric motor speech disorders. It is suggested that MPD+APD might be involved in typically apraxic speech output disorders and MPD in pediatric motor speech disorders that also have a phonological component. Possibilities to verify these hypotheses using empirical data collected from human subjects are discussed. PMID:24491630

  11. Estrogen influences dolichyl phosphate distribution among glycolipid pools in mouse uteri

    Energy Technology Data Exchange (ETDEWEB)

    Carson, D.D.; Tang, J.; Hu, G.

    1987-03-24

    To determine the role that dolichyl phosphate availability plays in this induction, the authors studied the effects of estrogen priming on the content of dolichyl phosphate and the distribution of dolichyl phosphate among various glycolipids in uteri. Dolichol-linked saccharides were metabolically labeled to equilibrium with either (/sup 3/H)glucosamine or (/sup 3/H)mannose and extracted from primary explants of uterine tissue. The amount of dolichol-linked saccharide was calculated from the specific radioactivity determined for the corresponding sugar nucleotides extracted from the tissues. The major dolichol-linked saccharides identified were mannosylphosphoryldolichol (MPD), oligosaccharylpyrophosphorydolichol (OSL), and N,N'-diacetylchitobiosylpyrophosphoryldolichol (CBL). Estrogen increased the levels of MPD and OSL 4-fold; however, CBL levels did not change. After 3 days of treatment, the levels of these glycolipids were very similar to those in uteri from pregnant mice. The specific activity of GPD synthase was similar under all conditions studied. These studies provide the first determination of the levels of dolichol-linked saccharides in tissues and how these levels change during hormonal induction of glycoprotein assembly. Coupled with earlier studies, the present work demonstrates that among a number of key points of N-linked oligosaccharide assembly and transfer only synthesis of MPD increases coordinately with the increase observed in lipid- and protein-linked oligosaccharide assembly that occurs in vivo in response to estrogen. They suggest that control of MPD levels is an important regulatory aspect of N-linked glycoprotein assembly in this system.

  12. Modelling of multifrequency IRMPD for laser isotope separation

    Indian Academy of Sciences (India)

    Unknown

    This model was exploited in analysing our MPD results ... separation method for 235U, the fissile isotope of uranium needed to fuel light water ... for analysis. The radio-GC consisted of a commercial GC (Shimadzu GC-R1A) equipped with thermal conductivity detector (TCD) and an indigenously built proportional counter.

  13. Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration

    Directory of Open Access Journals (Sweden)

    Lau Yuen-Sum

    2009-01-01

    Full Text Available Abstract Background Animal models of Parkinson's disease have been widely used for investigating the mechanisms of neurodegenerative process and for discovering alternative strategies for treating the disease. Following 10 injections with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 25 mg/kg and probenecid (250 mg/kg over 5 weeks in mice, we have established and characterized a chronic mouse model of Parkinson's disease (MPD, which displays severe long-term neurological and pathological defects resembling that of the human Parkinson's disease in the advanced stage. The behavioral manifestations in this chronic mouse model of Parkinson's syndrome remain uninvestigated. The health benefit of exercise in aging and in neurodegenerative disorders including the Parkinson's disease has been implicated; however, clinical and laboratory studies in this area are limited. In this research with the chronic MPD, we first conducted a series of behavioral tests and then investigated the impact of endurance exercise on the identified Parkinsonian behavioral deficits. Results We report here that the severe chronic MPD mice showed significant deficits in their gait pattern consistency and in learning the cued version of the Morris water maze. Their performances on the challenging beam and walking grid were considerably attenuated suggesting the lack of balance and motor coordination. Furthermore, their spontaneous and amphetamine-stimulated locomotor activities in the open field were significantly suppressed. The behavioral deficits in the chronic MPD lasted for at least 8 weeks after MPTP/probenecid treatment. When the chronic MPD mice were exercise-trained on a motorized treadmill 1 week before, 5 weeks during, and 8–12 weeks after MPTP/probenecid treatment, the behavioral deficits in gait pattern, spontaneous ambulatory movement, and balance performance were reversed; whereas neuronal loss and impairment in cognitive skill, motor coordination, and

  14. Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration

    Science.gov (United States)

    Pothakos, Konstantinos; Kurz, Max J; Lau, Yuen-Sum

    2009-01-01

    Background Animal models of Parkinson's disease have been widely used for investigating the mechanisms of neurodegenerative process and for discovering alternative strategies for treating the disease. Following 10 injections with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 25 mg/kg) and probenecid (250 mg/kg) over 5 weeks in mice, we have established and characterized a chronic mouse model of Parkinson's disease (MPD), which displays severe long-term neurological and pathological defects resembling that of the human Parkinson's disease in the advanced stage. The behavioral manifestations in this chronic mouse model of Parkinson's syndrome remain uninvestigated. The health benefit of exercise in aging and in neurodegenerative disorders including the Parkinson's disease has been implicated; however, clinical and laboratory studies in this area are limited. In this research with the chronic MPD, we first conducted a series of behavioral tests and then investigated the impact of endurance exercise on the identified Parkinsonian behavioral deficits. Results We report here that the severe chronic MPD mice showed significant deficits in their gait pattern consistency and in learning the cued version of the Morris water maze. Their performances on the challenging beam and walking grid were considerably attenuated suggesting the lack of balance and motor coordination. Furthermore, their spontaneous and amphetamine-stimulated locomotor activities in the open field were significantly suppressed. The behavioral deficits in the chronic MPD lasted for at least 8 weeks after MPTP/probenecid treatment. When the chronic MPD mice were exercise-trained on a motorized treadmill 1 week before, 5 weeks during, and 8–12 weeks after MPTP/probenecid treatment, the behavioral deficits in gait pattern, spontaneous ambulatory movement, and balance performance were reversed; whereas neuronal loss and impairment in cognitive skill, motor coordination, and amphetamine

  15. Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration.

    Science.gov (United States)

    Pothakos, Konstantinos; Kurz, Max J; Lau, Yuen-Sum

    2009-01-20

    Animal models of Parkinson's disease have been widely used for investigating the mechanisms of neurodegenerative process and for discovering alternative strategies for treating the disease. Following 10 injections with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 25 mg/kg) and probenecid (250 mg/kg) over 5 weeks in mice, we have established and characterized a chronic mouse model of Parkinson's disease (MPD), which displays severe long-term neurological and pathological defects resembling that of the human Parkinson's disease in the advanced stage. The behavioral manifestations in this chronic mouse model of Parkinson's syndrome remain uninvestigated. The health benefit of exercise in aging and in neurodegenerative disorders including the Parkinson's disease has been implicated; however, clinical and laboratory studies in this area are limited. In this research with the chronic MPD, we first conducted a series of behavioral tests and then investigated the impact of endurance exercise on the identified Parkinsonian behavioral deficits. We report here that the severe chronic MPD mice showed significant deficits in their gait pattern consistency and in learning the cued version of the Morris water maze. Their performances on the challenging beam and walking grid were considerably attenuated suggesting the lack of balance and motor coordination. Furthermore, their spontaneous and amphetamine-stimulated locomotor activities in the open field were significantly suppressed. The behavioral deficits in the chronic MPD lasted for at least 8 weeks after MPTP/probenecid treatment. When the chronic MPD mice were exercise-trained on a motorized treadmill 1 week before, 5 weeks during, and 8-12 weeks after MPTP/probenecid treatment, the behavioral deficits in gait pattern, spontaneous ambulatory movement, and balance performance were reversed; whereas neuronal loss and impairment in cognitive skill, motor coordination, and amphetamine-stimulated locomotor activity were not

  16. Clinical Characteristics of Cerebrovascular Pathology with Patients Suffering from Ph-Negative Myeloproliferative Disease

    Directory of Open Access Journals (Sweden)

    Marine M. Tanashyan

    2016-09-01

    Full Text Available Background: Disturbances of microcirculation play a significant role in the development and progression of both acute and chronic cerebrovascular diseases (CVD and may be associated with different hemogram abnormalities. One of the reasons of the prothrombogenic state of the endothelium is the increase in the number of blood corpuscles leading to (non-Ph myeloproliferative disorders (MPD including essential thrombocythemia (ET, polycythemia vera (PV, and primary myelofibrosis (PM. Materials and Methods: The study included 167 patients: 102 patients with Ph-MPD and the control group comprising 65 patients with CVD. According to MPD subtype, the patients were divided into three groups: patients with ET (37%, n = 38, male/female 7/31, age 52 ± 7 years, those with PV (40%, n = 41, male/female 20/21, age 50 ± 6 years and those with PM (23%, n = 23, male/female 5/18, age 54 ± 4 years. Results: In 79% (n = 81 of cases in the study group (with Ph-MPD, patients had chronic CVD, with the most frequently identified symptoms being asthenia (92% and headache (72%. Headache in Ph-MPD patients was more frequently (86% associated with PM, while in patients with PV and ET it was equally distributed (70%. Neurological symptoms in 53% of cases were associated with focal changes of the brain on MRI localized in the subcortical area of the frontal and parietal lobes. Twenty-one (21% patients suffered an acute cerebrovascular accident, 8 of them had thrombotic occlusion of one of the internal carotid arteries leading to hemispheric infarcts. Endothelial function (as measured by flow-dependent dilation of the brachial artery was severely impaired in all study groups (median 5% with normal cut-off at 10%, the lowest degree of vasodilator activity being specific for patients with a history of stroke (p = 0.011. Conclusion: Patients suffering from MPD had asymptomatic focal changes in the brain in the absence of concomitant vascular disease (hypertension

  17. Competing reaction channels in IR-laser-induced unimolecular reactions

    International Nuclear Information System (INIS)

    Berman, M.R.

    1981-01-01

    The competing reaction channels in the unimolecular decomposition of two molecules, formaldehyde and tetralin were studied. A TEA CO 2 laser was used as the excitation source in all experiments. The dissociation of D 2 CO was studied by infrared multiphoton dissociation (MPD) and the small-molecule nature of formaldehyde with regard to MPD was explored. The effect of collisions in MPD were probed by the pressure dependence of the MPD yield and ir fluorescence from multiphoton excited D 2 CO. MPD yield shows a near cubic dependence in pure D 2 CO which is reduced to a 1.7 power dependence when 15 torr of NO is added. The peak amplitude of 5 μm ir fluorescence from D 2 CO is proportional to the square of the D 2 CO pressure in pure D 2 CO or in the presence of 50 torr of Ar. Results are explained in terms of bottlenecks to excitation at the v = 1 level which are overcome by a combination of vibrational energy transfer and rotational relaxation. The radical/molecule branching ratio in D 2 CO MPD was 0.10 +- 0.02 at a fluence of 125 J/cm 2 at 946.0 cm -1 . The barrier height to molecular dissociation was calculated to be 3.6 +- 2.0 kcal/mole below the radical threshold or 85.0 +- 3.0 kcal/mole above the ground state of D 2 CO. In H 2 CO, this corresponds to 2.5 +- 2.0 kcal/mole below the radical threshold or 83.8 +- 3.0 kcal/mole above the ground state. Comparison with uv data indicate that RRKM theory is an acceptable description of formaldehyde dissociation in the 5 to 10 torr pressure range. The unimolecular decomposition of tetralin was studied by MPD and SiF 4 - sensitized pyrolysis. Both techniques induce decomposition without the interference of catalytic surfaces. Ethylene loss is identified as the lowest energy reaction channel. Dehydrogenation is found to result from step-wise H atom loss. Isomerization via disproportionation is also identified as a primary reaction channel

  18. Functional evaluation of circulating hematopoietic progenitors in Noonan syndrome

    Science.gov (United States)

    TIMEUS, FABIO; CRESCENZIO, NICOLETTA; BALDASSARRE, GIUSEPPINA; DORIA, ALESSANDRA; VALLERO, STEFANO; FOGLIA, LUISELDA; PAGLIANO, SARA; ROSSI, CESARE; SILENGO, MARGHERITA CIRILLO; RAMENGHI, UGO; FAGIOLI, FRANCA; DI MONTEZEMOLO, LUCA CORDERO; FERRERO, GIOVANNI BATTISTA

    2013-01-01

    Noonan syndrome (NS) is an autosomal dominant disorder, characterized by short stature, multiple dysmorphisms and congenital heart defects. A myeloproliferative disorder (NS/MPD), resembling juvenile myelomonocytic leukemia (JMML), is occasionally diagnosed in infants with NS. In the present study, we performed a functional evaluation of the circulating hematopoietic progenitors in a series of NS, NS/MPD and JMML patients. The different functional patterns were compared with the aim to identify a possible NS subgroup worthy of stringent hematological follow-up for an increased risk of MPD development. We studied 27 NS and 5 JMML patients fulfilling EWOG-MDS criteria. The more frequent molecular defects observed in NS were mutations in the PTPN11 and SOS genes. The absolute count of monocytes, circulating CD34+ hematopoietic progenitors, their apoptotic rate and the number of circulating CFU-GMs cultured in the presence of decreasing concentrations or in the absence of granulocyte-macrophage colony-stimulating factor (GM-CSF) were evaluated. All JMML patients showed monocytosis >1,000/μl. Ten out of the 27 NS patients showed monocytosis >1,000/μl, which included the 3 NS/MPD patients. In JMML patients, circulating CD34+ cells were significantly increased (median, 109.8/μl; range, 44–232) with a low rate of apoptosis (median, 2.1%; range, 0.4–12.1%), and circulating CFU-GMs were hyper-responsive to GM-CSF. NS/MPD patients showed the same flow cytometric pattern as the JMML patients (median, CD34+ cells/μl, 205.7; range, 58–1374; median apoptotic rate, 1.4%; range, 0.2–2.4%) and their circulating CFU-GMs were hyper-responsive to GM-CSF. These functional alterations appeared 10 months before the typical clinical manifestations in 1 NS/MPD patient. In NS, the CD34+ absolute cell count and circulating CFU-GMs showed a normal pattern (median CD34+ cells/μl, 4.9; range, 1.3–17.5), whereas the CD34+ cell apoptotic rate was significantly decreased in

  19. Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition.

    Science.gov (United States)

    Kleinpeter, Patricia; Fend, Laetitia; Thioudellet, Christine; Geist, Michel; Sfrontato, Nathalie; Koerper, Véronique; Fahrner, Catherine; Schmitt, Doris; Gantzer, Murielle; Remy-Ziller, Christelle; Brandely, Renée; Villeval, Dominique; Rittner, Karola; Silvestre, Nathalie; Erbs, Philippe; Zitvogel, Laurence; Quéméneur, Eric; Préville, Xavier; Marchand, Jean-Baptiste

    2016-01-01

    We report here the successful vectorization of a hamster monoclonal IgG (namely J43) recognizing the murine Programmed cell death-1 (mPD-1) in Western Reserve (WR) oncolytic vaccinia virus. Three forms of mPD-1 binders have been inserted into the virus: whole antibody (mAb), Fragment antigen-binding (Fab) or single-chain variable fragment (scFv). MAb, Fab and scFv were produced and assembled with the expected patterns in supernatants of cells infected by the recombinant viruses. The three purified mPD-1 binders were able to block the binding of mPD-1 ligand to mPD-1 in vitro . Moreover, mAb was detected in tumor and in serum of C57BL/6 mice when the recombinant WR-mAb was injected intratumorally (IT) in B16F10 and MCA 205 tumors. The concentration of circulating mAb detected after IT injection was up to 1,900-fold higher than the level obtained after a subcutaneous (SC) injection (i.e., without tumor) confirming the virus tropism for tumoral cells and/or microenvironment. Moreover, the overall tumoral accumulation of the mAb was higher and lasted longer after IT injection of WR-mAb1, than after IT administration of 10 µg of J43. The IT injection of viruses induced a massive infiltration of immune cells including activated lymphocytes (CD8 + and CD4 + ). Interestingly, in the MCA 205 tumor model, WR-mAb1 and WR-scFv induced a therapeutic control of tumor growth similar to unarmed WR combined to systemically administered J43 and superior to that obtained with an unarmed WR. These results pave the way for next generation of oncolytic vaccinia armed with immunomodulatory therapeutic proteins such as mAbs.

  20. Pancreatic MRI for the surveillance of cystic neoplasms: Comparison of a short with a comprehensive imaging protocol

    Energy Technology Data Exchange (ETDEWEB)

    Pozzi-Mucelli, Raffaella Maria; Kartalis, Nikolaos [C1-46 Karolinska University Hospital, Division of Medical Imaging and Technology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Department of Radiology, Stockholm (Sweden); Rinta-Kiikka, Irina [Tampere University Hospital, Department of Radiology, Medical Imaging Centre of Pirkanmaa Hospital District, Tampere (Finland); Wuensche, Katharina [St. Olavs University Hospital, Department of Radiology, Trondheim (Norway); Laukkarinen, Johanna [Tampere University Hospital, Department of Gastroenterology and Alimentary Tract Surgery, Tampere (Finland); Labori, Knut Joergen [Oslo University Hospital, Department of Hepato-Pancreato-Biliary Surgery, Oslo (Norway); Aanonsen, Kim [Oslo University Hospital, Department of Gastroenterology, Oslo (Norway); Verbeke, Caroline [Oslo University Hospital, Institute of Clinical Medicine, Oslo (Norway); Karolinska University Hospital, Department of Pathology, Stockholm (Sweden); Del Chiaro, Marco [Karolinska University Hospital, Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Center for Digestive Diseases, Stockholm (Sweden)

    2017-01-15

    The study aims were to evaluate: (1) whether a short-protocol (SP) MRI for the surveillance of pancreatic cystic neoplasms (PCN) provides equivalent clinical information as a comprehensive-protocol (CP), and (2) the cost reduction from substituting CP with SP for patient surveillance. This retrospective study included 154 consecutive patients (median age: 66, 52 % men) with working-diagnosis of PCN and available contrast-enhanced MRI/MRCP. Three radiologists evaluated independently two imaging sets (SP/CP) per patient. The CP included: T2-weighted (HASTE/MRCP), DWI and T1-weighted (chemical-shift/pre-/post-contrast) images [acquisition time (AT) ∼ 35 min], whereas the SP included: T2-weighted HASTE and T1-weighted pre-contrast images (AT ∼ 8 min). Mean values of largest cyst/main pancreatic duct diameter (D{sub C}/D{sub MPD}) were compared. Agreement regarding presence/absence of cystic/MPD mural nodules (MN{sub C}/MN{sub MPD}), inter-observer agreement and cost differences between SP/CP were calculated. For D{sub C} and D{sub MPD}, mean values with SP/CP were 21.4/21.7 mm and 3.52/3.58 mm, while mean differences SP-CP were 0.3 mm (p = 0.02) and 0.06 mm (p = 0.12), respectively. For presence/absence of MN{sub C} and MN{sub MPD}, SP/CP coincided in 93 % and 98 % of cases, respectively. Inter-observer agreement was strong for SP/CP. SP-cost was 25 % of CP-cost. For the surveillance of PCN, short-protocol MRI provides information equivalent to the more time-consuming and costly comprehensive-protocol. (orig.)

  1. DapE can function as an aspartyl peptidase in the presence of Mn2+.

    Science.gov (United States)

    Broder, Daniel H; Miller, Charles G

    2003-08-01

    Extracts of a multiply peptidase-deficient (pepNABDPQTE iadA iaaA) Salmonella enterica serovar Typhimurium strain contain an aspartyl dipeptidase activity that is dependent on Mn(2+). Purification of this activity followed by N-terminal sequencing of the protein suggested that the Mn(2+)-dependent peptidase is DapE (N-succinyl-L,L-diaminopimelate desuccinylase). A dapE chromosomal disruption was constructed and transduced into a multiply peptidase-deficient (MPD) strain. Crude extracts of this strain showed no aspartyl peptidase activity, and the strain failed to utilize Asp-Leu as a leucine source. The dapE gene was cloned into expression vectors in order to overproduce either the native protein (DapE) or a hexahistidine fusion protein (DapE-His(6)). Extracts of a strain carrying the plasmid overexpresssing native DapE in the MPD dapE background showed a 3,200-fold elevation of Mn(2+)-dependent aspartyl peptidase activity relative to the MPD dapE(+) strain. In addition, purified DapE-His(6) exhibited Mn(2+)-dependent peptidase activity toward aspartyl dipeptides. Growth of the MPD strain carrying a single genomic copy of dapE on Asp-Leu as a Leu source was slow but detectable. Overproduction of DapE in the MPD dapE strain allowed growth on Asp-Leu at a much faster rate. DapE was found to be specific for N-terminal aspartyl dipeptides: no N-terminal Glu, Met, or Leu peptides were hydrolyzed, nor were any peptides containing more than two amino acids. DapE is known to bind two divalent cations: one with high affinity and the other with lower affinity. Our data indicate that the form of DapE active as a peptidase contains Zn(2+) in the high-affinity site and Mn(2+) in the low-affinity site.

  2. Molecular plasma deposition: biologically inspired nanohydroxyapatite coatings on anodized nanotubular titanium for improving osteoblast density

    Directory of Open Access Journals (Sweden)

    Balasundaram G

    2015-01-01

    Full Text Available Ganesan Balasundaram,1 Daniel M Storey,1 Thomas J Webster2,3 1Chameleon Scientific, Longmont, CO, USA; 2Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 3Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: In order to begin to prepare a novel orthopedic implant that mimics the natural bone environment, the objective of this in vitro study was to synthesize nanocrystalline hydroxyapatite (NHA and coat it on titanium (Ti using molecular plasma deposition (MPD. NHA was synthesized through a wet chemical process followed by a hydrothermal treatment. NHA and micron sized hydroxyapatite (MHA were prepared by processing NHA coatings at 500°C and 900°C, respectively. The coatings were characterized before and after sintering using scanning electron microscopy, atomic force microscopy, and X-ray diffraction. The results revealed that the post-MPD heat treatment of up to 500°C effectively restored the structural and topographical integrity of NHA. In order to determine the in vitro biological responses of the MPD-coated surfaces, the attachment and spreading of osteoblasts (bone-forming cells on the uncoated, NHA-coated, and MHA-coated anodized Ti were investigated. Most importantly, the NHA-coated substrates supported a larger number of adherent cells than the MHA-coated and uncoated substrates. The morphology of these cells was assessed by scanning electron microscopy and the observed shapes were different for each substrate type. The present results are the first reports using MPD in the framework of hydroxyapatite coatings on Ti to enhance osteoblast responses and encourage further studies on MPD-based hydroxyapatite coatings on Ti for improved orthopedic applications. Keywords: hydroxyapatite, anodization, nanotechnology

  3. Novel microcephalic primordial dwarfism disorder associated with variants in the centrosomal protein ninein.

    Science.gov (United States)

    Dauber, Andrew; Lafranchi, Stephen H; Maliga, Zoltan; Lui, Julian C; Moon, Jennifer E; McDeed, Cailin; Henke, Katrin; Zonana, Jonathan; Kingman, Garrett A; Pers, Tune H; Baron, Jeffrey; Rosenfeld, Ron G; Hirschhorn, Joel N; Harris, Matthew P; Hwa, Vivian

    2012-11-01

    Microcephalic primordial dwarfism (MPD) is a rare, severe form of human growth failure in which growth restriction is evident in utero and continues into postnatal life. Single causative gene defects have been identified in a number of patients with MPD, and all involve genes fundamental to cellular processes including centrosome functions. The objective of the study was to find the genetic etiology of a novel presentation of MPD. The design of the study was whole-exome sequencing performed on two affected sisters in a single family. Molecular and functional studies of a candidate gene were performed using patient-derived primary fibroblasts and a zebrafish morpholino oligonucleotides knockdown model. Two sisters presented with a novel subtype of MPD, including severe intellectual disabilities. NIN, encoding Ninein, a centrosomal protein critically involved in asymmetric cell division, was identified as a candidate gene, and functional impacts in fibroblasts and zebrafish were studied. From 34,606 genomic variants, two very rare missense variants in NIN were identified. Both probands were compound heterozygotes. In the zebrafish, ninein knockdown led to specific and novel defects in the specification and morphogenesis of the anterior neuroectoderm, resulting in a deformity of the developing cranium with a small, squared skull highly reminiscent of the human phenotype. We identified a novel clinical subtype of MPD in two sisters who have rare variants in NIN. We show, for the first time, that reduction of ninein function in the developing zebrafish leads to specific deficiencies of brain and skull development, offering a developmental basis for the myriad phenotypes in our patients.

  4. Role of JAK-STAT signaling in the pathogenesis of myeloproliferative disorders.

    Science.gov (United States)

    Levine, Ross L; Wernig, Gerlinde

    2006-01-01

    The identification of JAK2V617F mutations in polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis (MF) represents an important advance in our understanding of these myeloproliferative disorders (MPD). Most, if not all, patients with PV and a significant number of patients with ET and MF are JAK2V617F positive, and the mutation likely arises in the hematopoietic stem cell compartment. JAK2V617F is a constitutively active tyrosine kinase that is able to activate JAK-STAT signaling most efficiently when co-expressed with the erythropoietin receptor (EPOR), the thrombopoietin receptor (MPL), or the granulocyte colony-stimulating factor receptor (GCSFR). Data from murine models supports the central role of JAK2V617F in the pathogenesis of MPD, as expression of JAK2V617F in a bone marrow transplantation assay results in polycythemia and myelofibrosis in recipient mice. Activation of JAK-STAT signaling by JAK2V617F in some, but not all MPD patients with ET and MF led to the identification of the constitutively active MPLW515L allele in ET and MF. Small molecule inhibitors of JAK-STAT signaling are currently being developed, which offer potential for molecularly targeted therapy for patients with PV, ET, and MF. Despite these advances, many questions remain regarding the role of a single disease allele in three phenotypically distinct MPD, the potential clinical efficacy of JAK2 inhibitors, and the identity of oncogenic alleles in JAK2V617F/MPLW515-negative MPD.

  5. Missed pancreatic ductal adenocarcinoma: Assessment of early imaging findings on prediagnostic magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Kyung Mi; Kim, Seong Hyun, E-mail: sh6453.kim@samsung.com; Kim, Young Kon; Song, Kyoung Doo; Lee, Soon Jin; Choi, Dongil

    2015-08-15

    Highlights: • MR imaging was superior to CT for the detection of early PDAC. • A focal lesion with no MPD interruption is common MR finding of early PDAC. • A mean volume doubling time of early PDAC was about five months. - Abstract: Objective: To investigate the early imaging findings and growth rate of pancreatic ductal adenocarcinoma (PDAC), and to assess whether MR imaging detects early PDAC better than CT. Materials and methods: The institutional review board approved this retrospective study and waived the requirement for informed consent. Twenty-two patients were included, and two radiologists, by consensus, assessed the presence of focal lesions, interruption of the main pancreatic duct (MPD), MPD dilatation, and pancreatitis, volume doubling time (VDT) of PDAC on prediagnostic MR imaging. Two other observers independently reviewed three image sets (CT images, unenhanced MR images, and unenhanced and contrast-enhanced MR images) for the detection of early PDAC. Paired Wilcoxon signed rank test and receiver operating characteristic (ROC) curve analysis were used for statistical analyses. Results: In 20 (90.9%) patients, prediagnostic MR exams showed abnormality, and all of them showed focal lesions on the first abnormal prediagnostic MR exams. Thirteen lesions (65%) showed no MPD interruption and one lesion (5%) was accompanied by pancreatitis. The mean VDT of PDAC was 151.7 days (range, 18.3–417.8 days). Diagnostic performance of unenhanced MR images (Az, 0.971–0.989) and combined unenhanced and contrast-enhanced MR images (Az, 0.956–0.963) was significantly better than that of CT images (Az, 0.565–0.583; p < 0.01) for both observers, Conclusion: The most common early imaging finding of PDAC on prediagnostic MR exams was a focal lesion with no MPD interruption with a mean volume doubling time of five months. MR imaging was superior to CT for the detection of early PDAC.

  6. The Elusive Palladium-Diazo Adduct Captured: Synthesis, Isolation and Structural Characterization of [(ArNHC-PPh2 )Pd(η2 -N2 C(Ph)CO2 Et)].

    Science.gov (United States)

    Rull, Silvia G; Álvarez, Eleuterio; Fructos, Manuel R; Belderrain, Tomás R; Pérez, Pedro J

    2017-06-07

    The first example of a diazo palladium adduct is reported. The complexes [(ArNHC-PPh 2 )M(η 2 -N 2 C(Ph)CO 2 Et)] (M=Ni, 3; M=Pd, 4; ArNHC-PPh 2 =3-(2,6-diisopropylphenyl)-1-[(diphenylphosphino)ethyl]imidazol-2-ylidene) were prepared by ligand exchange with styrene-coordinated precursors [(ArNHC-PPh 2 )M(styrene)] (M=Ni, 1; M=Pd, 2). Complex 4 was fully characterized, including X-ray analyses; this constitutes the first example of a diazo adduct compound with palladium, thereby closing the gap between Groups 8 and 10 regarding this type of compounds. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Functional MR-pancreatography with secretin - a comparison of imaging quality and diagnostic value pre and post secretin in the same patient

    International Nuclear Information System (INIS)

    Helmberger, H.; Hellerhoff, K.; Ruell, T.; Brandt, C.; Gerhardt, P.

    2000-01-01

    Purpose: The aim of the present study was to assess imaging improvement and diagnostic value of secretin stimulated MR-pancreatography (MRP) compared to conventional MRP. Materials and Methods: 50 patients were studied with a 1.0 T system using a single-shot-TSE sequence (RARE). Imaging quality and diameter of the different parts of the pancreatic tract and diagnoses were monitored before and after secretin. Results: The visualization of the normal main pancreatic duct (MPD) was improved significantly in head, body and tail. Side branches were not depicted at all. Even in chronic pancreatitis a significant improvement of imaging quality could be observed, but only in patients without duct dilation before secretin. In advanced disease with duct dilation, secretin stimulation provided no further diagnostic improvement. Conclusions: In conclusion, secretin increases the diagnostic value of MRP especially in patients with normal or non-dilated native MPD and may help to avoid unnecessary invasive procedures such as ERCP. (orig.) [de

  8. Analyzing and modeling interdisciplinary product development a framework for the analysis of knowledge characteristics and design support

    CERN Document Server

    Neumann, Frank

    2015-01-01

    Frank Neumann focuses on establishing a theoretical basis that allows a description of the interplay between individual and collective processes in product development. For this purpose, he introduces the integrated descriptive model of knowledge creation as the first constituent of his research framework. As a second part of the research framework, an analysis and modeling method is proposed that captures the various knowledge conversion activities described by the integrated descriptive model of knowledge creation. Subsequently, this research framework is applied to the analysis of knowledge characteristics of mechatronic product development (MPD). Finally, the results gained from the previous steps are used within a design support system that aims at federating the information and knowledge resources contained in the models published in the various development activities of MPD. Contents Descriptive Model of Knowledge Creation in Interdisciplinary Product Development Research Framework for the Analysis of ...

  9. Tests of microprocessor-based relay protection devices: Problems and solutions

    Directory of Open Access Journals (Sweden)

    Gurevich Vladimir

    2009-01-01

    Full Text Available Usually, the operational condition of relay protection devices is checked with specific settings used for the relay operation in a certain network point. In the author's opinion in order to verify the proper operation of complex multifunctional microprocessor-based protection devices (MPD at their inspection, start-up after repairs or during periodic tests there is no need to use the actual settings at which the relay is to be operated in a certain network's point. It should be tested for proper operation at several of its most critical preset characteristic points as well as in several preset characteristics constituting its most complicated (combined operation modes, including the dynamic operation modes with preset transition processes specific for standard power networks (not necessarily for a specific point. The proposed set of actions for the unification of software platforms of the modern, microprocessor-based relay protection test systems will enable examination of modern MPD in an absolutely new way. .

  10. Growth hormone deficiency and hyperthermia during exercise

    DEFF Research Database (Denmark)

    Juul, A; Hjortskov, N; Jepsen, Leif

    1995-01-01

    -deficiency may be at risk for developing hyperthermia. To pursue this, we performed a controlled study on sweating and body temperature regulation during exercise in the heat in 16 GH-treated GH-deficient patients with normalized insulin-like growth factor-I and insulin-like growth factor/binding protein-3 serum.......001]. Consequently, the core temperatures of the patients increased significantly after exercise compared with those of the CTs [38.3 C (0.10 C) (MPD) and 38.1 C (0.06 C) (isolated GH deficiency) vs. 37.5 C (0.2 C) (CTs) (P temperature increased significantly during exercise in the patients...... but remained unaltered in the CTs. Sweat secretion rates, as determined by the pilocarpine method, were significantly lower in the MPD patients [77 (SE +/- 10) mg/30 min] than in the CTs [115 (SE +/- 7) mg/30 min] (P

  11. Pregnant x-ray technologist: providing adequate radiation safety for the fetus

    International Nuclear Information System (INIS)

    Caprio, M.L. Jr.

    1980-01-01

    The human embryo-fetus is highly radiosensitive and must be protected from excessive exposure to ionizing radiation. The maximum permissible dose equivalent for the developing embryo-fetus is set at 0.5 rem per year - the MPD level for members of the general public. Methods by which supervisory personnel can limit the fetal dose incurred by the occupational exposure of the mother are presented. It is recommended that supervisory personnel attempt to limit occupational exposure to the current non-occupational MPD levels for all x-ray technologists, thereby, insuring that the fetal dose limits are not surpassed and providing an added safety factor for personnel by keeping exposures as low as reasonably achievable

  12. Early Detection and Localization of Downhole Incidents in Managed Pressure Drilling

    DEFF Research Database (Denmark)

    Willersrud, Anders; Imsland, Lars; Blanke, Mogens

    2015-01-01

    Downhole incidents such as kick, lost circulation, pack-off, and hole cleaning issues are important contributors to downtime in drilling. In managed pressure drilling (MPD), operations margins are typically narrower, implying more frequent incidents and more severe consequences. Detection...... and handling of symptoms of downhole drilling contingencies at an early stage are therefore crucial for the reliability and safety of MPD operations. In this paper we describe a method for early detection and localization of such incidents, based on a fit for purpose model of the downhole pressure hydraulics...... successfully been tested on experimental data from a medium-scale horizontal flow loop in Sta- vanger, Norway. The flow loop represents a 700 m borehole with emulation of the following downhole contingencies: drillstring washout, drill bit nozzle plugging, gas influx and fluid loss. In the tests...

  13. Ex-reactor determination of thermal gap and contact conductance between uranium dioxide: zircaloy-4 interfaces. Stage I: low gas pressure. [PWR; BWR

    Energy Technology Data Exchange (ETDEWEB)

    Garnier, J.E.; Begej, S.

    1979-04-01

    A study of thermal gap and contact conductance between depleted uranium dioxide (UO/sub 2/) and Zircaloy-4 (Zr4) has been made utilizing two measurement apparatuses developed as part of this program. The Modified Pulse Design (MPD) apparatus is a transient technique employing a heat pulse (laser) and a signal detector to monitor the thermal energy transmitted through a UO/sub 2//Zr4 sample pair which are either physically separated or in contact. The Modified Longitudinal Design (MLD) apparatus is a steady-state technique based on a modified cylindrical column design with a self-guarding sample geometry. Description of the MPD and MLD apparatus, data acquisition, reduction and error analysis is presented along with information on specimen preparation, thermal property and surface characterization. A technique using an optical height gauge to determine the average mean-plane of separation between the simple pairs is also presented.

  14. Ex-reactor determination of thermal gap and contact conductance between uranium dioxide: zircaloy-4 interfaces. Stage I: low gas pressure

    International Nuclear Information System (INIS)

    Garnier, J.E.; Begej, S.

    1979-04-01

    A study of thermal gap and contact conductance between depleted uranium dioxide (UO 2 ) and Zircaloy-4 (Zr4) has been made utilizing two measurement apparatuses developed as part of this program. The Modified Pulse Design (MPD) apparatus is a transient technique employing a heat pulse (laser) and a signal detector to monitor the thermal energy transmitted through a UO 2 /Zr4 sample pair which are either physically separated or in contact. The Modified Longitudinal Design (MLD) apparatus is a steady-state technique based on a modified cylindrical column design with a self-guarding sample geometry. Description of the MPD and MLD apparatus, data acquisition, reduction and error analysis is presented along with information on specimen preparation, thermal property and surface characterization. A technique using an optical height gauge to determine the average mean-plane of separation between the simple pairs is also presented

  15. Similar or disparate brain patterns? The intra-personal EEG variability of three women with multiple personality disorder.

    Science.gov (United States)

    Lapointe, A R; Crayton, J W; DeVito, R; Fichtner, C G; Konopka, L M

    2006-07-01

    Quantitative EEG was used to assess the intra-personal variability of brain electrical activity for 3 women diagnosed with Multiple Personality Disorder (MPD). Two separate control groups (within-subject and between-subject) were used to test the hypothesis that the intra-personal EEG variability between 2 alters would be less than the interpersonal EEG variability between 2 controls, and similar to the intra-personal EEG variability of a single personality. This hypothesis was partially supported. In general, the 2 EEG records of a MPD subject (alter 1 vs. alter 2) were more different from one another than the 2 EEG records of a single control, but less different from one another than the EEG records of 2 separate controls. Most of the EEG variability between alters involved beta activity in the frontal and temporal lobes.

  16. Isolated Main Pancreatic Duct Dilatation: CT Differentiation Between Benign and Malignant Causes.

    Science.gov (United States)

    Kim, Se Woo; Kim, Se Hyung; Lee, Dong Ho; Lee, Sang Min; Kim, Yeon Soo; Jang, Jin Young; Han, Joon Koo

    2017-11-01

    The purpose of this study is to retrospectively evaluate the differential CT features of isolated benign and malignant main pancreatic duct (MPD) dilatation and to investigate whether the diagnostic performance of radiologists can be improved with knowledge of these differential CT features. Forty-one patients who had isolated MPD dilatation without any visible mass on CT from January 2000 to October 2016 were retrospectively enrolled in the study. Two radiologists reviewed CT images in consensus for the location, shape (smooth vs abrupt), length of transition, dilated pancreatic duct (PD) diameter, presence of duct penetrating sign, parenchymal atrophy, attenuation difference, associated pancreatitis, calcification, PD or common bile duct (CBD) enhancement, and perilesional cyst. The chi-square test, Fisher exact test, and t test were used to find the differential CT features of benign and malignant MPD dilatation. Two successive review sessions for differentiation between the two disease entities were then independently performed by three other reviewers with differing expertise, with the use of a 5-point confidence scale. The first session provided no information for differentiation; however, reviewers were aware of the results of univariate analyses in the second session. The diagnostic performance of the radiologists was evaluated using a pairwise comparison of ROC curves. A total of 19 benign and 22 malignant MPD dilatations were identified. In patients with benign MPD dilatation, transition areas were frequently located in the head (57.9% [11/19] vs 13.6% [3/22], p = 0.003) and showed significantly shorter (< 6.1 mm) (78.9% [15/19] vs 9.1% [2/22], p < 0.0001) and smooth transition (89.5% [17/19] vs 9.1% [2/22], p < 0.0001). Duct penetrating sign was exclusively observed in patients with benign MPD dilatation (73.7% [14/19] vs 0% [0/22], p < 0.0001). In contrast, malignant MPD dilatation frequently was accompanied by attenuation difference (63.6% [14/22] vs

  17. Metastatic Extramammary Paget’s Disease of Scrotum Responds Completely to Single Agent Trastuzumab in a Hemodialysis Patient: Case Report, Molecular Profiling and Brief Review of the Literature

    Directory of Open Access Journals (Sweden)

    Peter Barth

    2015-01-01

    metastatic the prognosis of EMPD is poor and treatment options are limited. We report a case of a complete response to single agent trastuzumab in a hemodialysis patient with metastatic Her2/neu overexpressed EMPD of the scrotum. Molecular profiling of his case as well as 12 other EMPD and 8 mammary Paget disease (MPD cases was completed and revealed multiple biomarker aberrations. Overexpression of Her2 was frequently noted (30%–40% in both EMPD and MPD patients and when present can be effectively treated with Her2 targeted agents. Trastuzumab therapy can be safely utilized in a hemodialysis patient. In addition, multiple protein overexpression and loss were seen in EMPD including PD-1, PD-L1, PTEN, and AR as well as PIK3CA mutation. These findings may lead to possible therapeutic interventions targeting these pathways in a disease with few effective treatment options.

  18. Pancreatic Serous Cystadenoma with Compression of the Main Pancreatic Duct: An Unusual Entity

    Directory of Open Access Journals (Sweden)

    Stéphanie Truant

    2011-01-01

    Full Text Available Serous cystadenoma is a common benign neoplasm that can be managed without surgery in asymptomatic patients provided that the diagnosis is certain. We describe a patient, whose pancreatic cyst exhibited a radiological appearance distinct from that of typical serous cystadenoma, resulting in diagnostic difficulties. CT and MRI showed a 10 cm-polycystic tumor with upstream dilatation of the main pancreatic duct (MPD, suggestive of intraductal papillary mucinous tumor (IPMT. Ultrasonographic aspect and EUS-guided fine-needle aspiration gave arguments for serous cystadenoma. ERCP showed a communication between cysts and the dilated MPD, compatible with IPMT. The patient underwent left pancreatectomy with splenectomy. Pathological examination concluded in a serous cystadenoma, with only a ductal obstruction causing proximal dilatation.

  19. Development and validation of a stochastic model for potential growth of Listeria monocytogenes in naturally contaminated lightly preserved seafood

    DEFF Research Database (Denmark)

    Mejlholm, Ole; Bøknæs, Niels; Dalgaard, Paw

    2015-01-01

    added acetic and/or lactic acids. The stochastic model was developed from an existing deterministic model including the effect of 12 environmental parameters and microbial interaction (O. Mejlholm and P. Dalgaard, Food Microbiology, submitted for publication). Observed maximum population density (MPD...... of the least and most preserved sample of CSGH and CSS were used as input for the existing deterministic model. For both modelling approaches, it was shown that lag time and the effect of microbial interaction needs to be included to accurately predict MPD values of L. monocytogenes. Addition of organic acids...... to CSGH and CSS was confirmed as a suitable mitigation strategy against the risk of growth by L. monocytogenes as both types of products were in compliance with the EU regulation on ready-to-eat foods....

  20. [Dissociative disorders: from Janet to DSM-IV].

    Science.gov (United States)

    Nakatani, Y

    2000-01-01

    dissociation and trauma was revived in different areas: the feminism movement was linked with concerns about child sexual abuse, public curiosity about multiple personalities was heightened by novels and movies, and recognition of posttraumatic stress disorder (PTSD) among Vietnam War veterans. In 1980, dissociative disorders were finally adopted as a diagnostic category in the official nomenclature of DSM-III. Although current research on dissociation is being carried out in various fields, two basic assumptions, reflected in the definition of DSM-IV, can be made. One is the "trauma-genic hypothesis," and the other is the great importance attached to multiple personality disorder (MPD). According to the predominantly held view, dissociation represents a reaction to early traumatic experience, especially sexual and physical abuse in childhood. In contrast, some authors argue that the causality of childhood traumatic experience has not been empirically confirmed, and other factors such as the influence of the environment and the predisposition of patients should be taken into consideration. MPD, which was originally described as an unusual phenomenon in classical literature, is currently thought to be a common type of dissociation. However, the reported rapid increase in the number of MPD patients in North America may be partially due to over-diagnosis and inclusion of iatrogenic cases. Significance is also given to MPD in respect to classification of dissociative phenomena. According to the widely held scheme of a "dissociative continuum," which ranges from normal experiences such as daydreams to pathological states, MPD is placed at the extreme end of the continuum. Furthermore, most researchers tend to classify MPD as the severest dissociative disorder due to chronic trauma. On this point, there seems to be confusion about "extremity" and "severity" of MPD. I conclude that the trauma-genic hypothesis of dissociation and the overemphasis placed on MPD should be reexamin

  1. Radiation abuse and its effects

    Energy Technology Data Exchange (ETDEWEB)

    Halm, A

    1976-06-01

    This paper delves into overuse practiced in diagnostic radiography. The conventional attitudes to low-dose irradiation are critically examined, as is the MPD related to individual radiosensitivity. Concern is expressed that a sizeable proportion of radiologists ignore important aspects of the Code of Practice and this attitude is readily emulated in the hospital setting. The author advocates education within the medical profession and the community on the risks involved in radiation abuse and the benefits derived from justified exposures to x rays.

  2. Handling and Transport Problems

    Energy Technology Data Exchange (ETDEWEB)

    Pomarola, J. [Head of Technical Section, Atomic Energy Commission, Saclay (France); Savouyaud, J. [Head of Electro-Mechanical Sub-Division, Atomic Energy Commission, Saclay (France)

    1960-07-01

    Arrangements for special or dangerous transport operations by road arising out of the activities of the Atomic Energy Commission are made by the Works and Installations Division which acts in concert with the Monitoring and Protection Division (MPD) whenever radioactive substances or appliances are involved. In view of the risk of irradiation and contamination entailed in handling and transporting radioactive substances, including waste, a specialized transport and storage team has been formed as a complement to the emergency and decontamination teams.

  3. Optimization of Munitions Storage.

    Science.gov (United States)

    1979-12-01

    zones of land around each facility place a significant economic cost on the storage of munitions (Schreyer, 1970: 1). Munitions storage is a subject...ADDTOT, BTOTAL 353 REAL MPH,MW ,MPD, MPU ,4,MPNEW,MCD 354 IF (SW2.NE.0) GO TO 1 355 SW2 - 1 356 WRITE (6,2) 357 GO TO 3 358 1 IF (REC.EQ.0) GO TO 4 359 IF

  4. Auditory-motor interactions in pediatric motor speech disorders: neurocomputational modeling of disordered development.

    Science.gov (United States)

    Terband, H; Maassen, B; Guenther, F H; Brumberg, J

    2014-01-01

    Differentiating the symptom complex due to phonological-level disorders, speech delay and pediatric motor speech disorders is a controversial issue in the field of pediatric speech and language pathology. The present study investigated the developmental interaction between neurological deficits in auditory and motor processes using computational modeling with the DIVA model. In a series of computer simulations, we investigated the effect of a motor processing deficit alone (MPD), and the effect of a motor processing deficit in combination with an auditory processing deficit (MPD+APD) on the trajectory and endpoint of speech motor development in the DIVA model. Simulation results showed that a motor programming deficit predominantly leads to deterioration on the phonological level (phonemic mappings) when auditory self-monitoring is intact, and on the systemic level (systemic mapping) if auditory self-monitoring is impaired. These findings suggest a close relation between quality of auditory self-monitoring and the involvement of phonological vs. motor processes in children with pediatric motor speech disorders. It is suggested that MPD+APD might be involved in typically apraxic speech output disorders and MPD in pediatric motor speech disorders that also have a phonological component. Possibilities to verify these hypotheses using empirical data collected from human subjects are discussed. The reader will be able to: (1) identify the difficulties in studying disordered speech motor development; (2) describe the differences in speech motor characteristics between SSD and subtype CAS; (3) describe the different types of learning that occur in the sensory-motor system during babbling and early speech acquisition; (4) identify the neural control subsystems involved in speech production; (5) describe the potential role of auditory self-monitoring in developmental speech disorders. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism.

    Science.gov (United States)

    Mirzaa, Ghayda M; Vitre, Benjamin; Carpenter, Gillian; Abramowicz, Iga; Gleeson, Joseph G; Paciorkowski, Alex R; Cleveland, Don W; Dobyns, William B; O'Driscoll, Mark

    2014-08-01

    Defects in centrosome, centrosomal-associated and spindle-associated proteins are the most frequent cause of primary microcephaly (PM) and microcephalic primordial dwarfism (MPD) syndromes in humans. Mitotic progression and segregation defects, microtubule spindle abnormalities and impaired DNA damage-induced G2-M cell cycle checkpoint proficiency have been documented in cell lines from these patients. This suggests that impaired mitotic entry, progression and exit strongly contribute to PM and MPD. Considering the vast protein networks involved in coordinating this cell cycle stage, the list of potential target genes that could underlie novel developmental disorders is large. One such complex network, with a direct microtubule-mediated physical connection to the centrosome, is the kinetochore. This centromeric-associated structure nucleates microtubule attachments onto mitotic chromosomes. Here, we described novel compound heterozygous variants in CENPE in two siblings who exhibit a profound MPD associated with developmental delay, simplified gyri and other isolated abnormalities. CENPE encodes centromere-associated protein E (CENP-E), a core kinetochore component functioning to mediate chromosome congression initially of misaligned chromosomes and in subsequent spindle microtubule capture during mitosis. Firstly, we present a comprehensive clinical description of these patients. Then, using patient cells we document abnormalities in spindle microtubule organization, mitotic progression and segregation, before modeling the cellular pathogenicity of these variants in an independent cell system. Our cellular analysis shows that a pathogenic defect in CENP-E, a kinetochore-core protein, largely phenocopies PCNT-mutated microcephalic osteodysplastic primordial dwarfism-type II patient cells. PCNT encodes a centrosome-associated protein. These results highlight a common underlying pathomechanism. Our findings provide the first evidence for a kinetochore-based route to

  6. Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders

    OpenAIRE

    Gery, Sigal; Gueller, Saskia; Chumakova, Katya; Kawamata, Norihiko; Liu, Liqin; Koeffler, H. Phillip

    2007-01-01

    Recently, activating myeloproliferative leukemia virus oncogene (MPL) mutations, MPLW515L/K, were described in myeloproliferative disorder (MPD) patients. MPLW515L leads to activation of downstream signaling pathways and cytokine-independent proliferation in hematopoietic cells. The adaptor protein Lnk is a negative regulator of several cytokine receptors, including MPL. We show that overexpression of Lnk in Ba/F3-MPLW515L cells inhibits cytokine-independent growth, while suppression of Lnk i...

  7. The TITAN Reversed-Field Pinch fusion reactor study: Scoping phase report

    International Nuclear Information System (INIS)

    1987-01-01

    The TITAN research program is a multi-institutional effort to determine the potential of the Reversed-Field Pinch (RFP) magnetic fusion concept as a compact, high-power-density, and ''attractive'' fusion energy system from economic (cost of electricity, COE), environmental, and operational viewpoints. In particular, a high neutron wall loading design (18 MW/m 2 ) has been chosen as the reference case in order to quantify the issue of engineering practicality, to determine the physics requirements and plasma operating mode, to assess significant benefits of compact systems, and to illuminate the main drawbacks. The program has been divided into two phases, each roughly one year in length: the Scoping Phase and the Design Phase. During the scoping phase, the TITAN design team has defined the parameter space for a high mass power density (MPD) RFP reactor, and explored a variety of approaches to the design of major subsystems. Two major design approaches consistent with high MPD and low COE, the lithium-vanadium blanket design and aqueous loop-in-pool design, have been selected for more detailed engineering evaluation in the design phase. The program has retained a balance in its approach to investigating high MPD systems. On the one hand, parametric investigations of both subsystems and overall system performance are carried out. On the other hand, more detailed analysis and engineering design and integration are performed, appropriate to determining the technical feasibility of the high MPD approach to RFP fusion reactors. This report describes the work of the scoping phase activities of the TITAN program. A synopsis of the principal technical findings and a brief description of the TITAN multiple-design approach is given. The individual chapters on Plasma Physics and Engineering, Parameter Systems Studies, Divertor, Reactor Engineering, and Fusion Power Core Engineering have been cataloged separately

  8. The TITAN Reversed-Field Pinch fusion reactor study: Scoping phase report

    Energy Technology Data Exchange (ETDEWEB)

    1987-01-01

    The TITAN research program is a multi-institutional effort to determine the potential of the Reversed-Field Pinch (RFP) magnetic fusion concept as a compact, high-power-density, and ''attractive'' fusion energy system from economic (cost of electricity, COE), environmental, and operational viewpoints. In particular, a high neutron wall loading design (18 MW/m/sup 2/) has been chosen as the reference case in order to quantify the issue of engineering practicality, to determine the physics requirements and plasma operating mode, to assess significant benefits of compact systems, and to illuminate the main drawbacks. The program has been divided into two phases, each roughly one year in length: the Scoping Phase and the Design Phase. During the scoping phase, the TITAN design team has defined the parameter space for a high mass power density (MPD) RFP reactor, and explored a variety of approaches to the design of major subsystems. Two major design approaches consistent with high MPD and low COE, the lithium-vanadium blanket design and aqueous loop-in-pool design, have been selected for more detailed engineering evaluation in the design phase. The program has retained a balance in its approach to investigating high MPD systems. On the one hand, parametric investigations of both subsystems and overall system performance are carried out. On the other hand, more detailed analysis and engineering design and integration are performed, appropriate to determining the technical feasibility of the high MPD approach to RFP fusion reactors. This report describes the work of the scoping phase activities of the TITAN program. A synopsis of the principal technical findings and a brief description of the TITAN multiple-design approach is given. The individual chapters on Plasma Physics and Engineering, Parameter Systems Studies, Divertor, Reactor Engineering, and Fusion Power Core Engineering have been cataloged separately.

  9. Associations between food insecurity and the severity of psychological distress among African-Americans.

    Science.gov (United States)

    Allen, Nickolas L; Becerra, Benjamin J; Becerra, Monideepa B

    2018-07-01

    Little research exists on the association between food insecurity and mild to moderate psychological distress (MPD) among Black/African-Americans. In this study, we assess the relationship between food insecurity with and without hunger to that of both MPD and serious psychological distress (SPD) among this population. 2009 and 2011/2012 adult public-use data from African-American respondents of the California Health Interview Survey were utilized for this study (n = 4003). Descriptive statistics were utilized to identify prevalence of psychological distress among sociodemographic and mental-health associated variables. Bivariate analyses were conducted between these variables and psychological distress using survey-weighted chi-square analyses. To evaluate the association between psychological distress, our primary exposure variable of food security, and other variables, we utilized survey-weighted multinomial logistic regression. Prevalence of mild to MPD was higher among those reporting food insecurity while SPD was highest for those with food insecurity and hunger. Results of multinomial logistic regression analysis demonstrate that while MPD was significantly associated with food insecurity, Black/African-Americans with food insecurity and hunger displayed over sixfold odds of higher serious psychological distress, as compared to those living at or above 200% federal poverty level. Our findings add to this growing segment of the literature on psychological distress and food insecurity. Further focus should be placed on improving the efficacy and reach of both formal and informal food support networks to improve the collective health and well-being of poor Black/African-American communities.

  10. On a Diagnosed Case of Multiple Personality Disorder -A Supplementary Report with Special Reference to Psychotherapy-

    OpenAIRE

    藤田, 裕司

    2000-01-01

    As a supplement of the study on a dignosed case of MPD (Multiple Personality Disorder), the effect of the psychotherapy was discussed. The patient was a twenty-four-year-old woman suspected of an attempted murder. In this article, continued from the previous one reporting the process of a series of ten psychotherapeutic interviews with her, the general comment on that was made, and the merits and demerits of the psychotherapy were clarified.

  11. Ultrathin Polyamide Membranes Fabricated from Free-Standing Interfacial Polymerization: Synthesis, Modifications, and Post-treatment

    KAUST Repository

    Cui, Yue

    2016-12-21

    The thin film composite (TFC) membrane synthesized via interfacial polymerization is the workhorse of the prevalent membrane technologies such as nanofiltration (NF), reverse osmosis (RO), forward osmosis (FO), and pressure retarded osmosis (PRO) membranes. The polyamide selective layer usually possesses a high selectivity and permeability, making it the heart of this membrane technology. To further improve and understand its formation, with entirely excluding the effect of substrate, an ultrathin membrane which consists of only the polyamide selective layer has been fabricated via free-standing interfacial polymerization between M-phenylenediamine (MPD) and trimesoyl chloride (TMC) in this study. The influences of monomer concentration on polyamide layer formation is first examined. Different from previous studies which indicated that the variation of MPD concentration might affect the polyamide layer formation even when in excess, the MPD concentration when in excess does not affect membrane properties significantly, while increasing the TMC concentration gradually densifies the polyamide layer and enhances its transport resistance. Adding lithium bromide (LiBr) and sodium dodecyl sulfate (SDS) in MPD solutions is found to facilitate the reaction between the two phases and result in a significant improvement in water permeability. However, a high amount of additives leads to an augmentation in transport resistance. The N,N-dimethylformamide (DMF) treatment on the polyamide membrane shows pronounced improvements on water flux under FO tests and water permeability under RO tests without compromising reverse salt flux and salt rejection because the dense polyamide core stays intact. This study may offer a different perspective on membrane formation and intrinsic properties of the polyamide selective layer and provide useful insights for the development of next-generation TFC membranes.

  12. An Aircraft Lifecycle Approach for the Cost-Benefit Analysis of Prognostics and Condition-Based Maintenance-Based on Discrete-Event Simulation

    Science.gov (United States)

    2014-10-02

    MPD. This manufacturer documentation contains maintenance tasks with specification of intervals and required man-hours that are to be carried out...failures, without consideration of false alarms and missed failures (see also section 4.1.3). The task redundancy rate is the percentage of preventive...Prognostics and Health Management ROI return on investment RUL remaining useful life TCG task code group SB Service Bulletin XML Extensible Markup

  13. A Novel Method for Detection of Glycoproteins on Sodium Dodecyl Sulphate Polyacrylamide Gel Using Radio-Iodinated Tyrosine

    DEFF Research Database (Denmark)

    Nalla, Amarnadh; Draz, Hossam M.; Dole, Anita

    2009-01-01

    The aim of this study is to develop a novel method for detection of glycoproteins on polyacrylamide gel. In this method, radio-iodinated-tyrosine (125I-tyrosine) was conjugated to glycoprotein by schiff's base mechanism on the sodium dodecyl sulfate- polyacrylamide gel. Ovalbumin and Concanavalin...... of glycoproteins using 125I-tyrosine selectively detected ovalbumin. Present results showed that MPD enhanced glycoprotein detection method can be used as a sensitive tool for the detection of glycoproteins on polyacrylamide gel...

  14. Crystallization of DNA fragments from water-salt solutions, containing 2-methylpentane-2,3-diol.

    Science.gov (United States)

    Osica, V D; Sukharevsky, B Y; Vasilchenko, V N; Verkin, B I; Polyvtsev, O F

    1976-09-01

    Fragments of calf thymus DNA have been crystallized by precipitation from water-salt solutions, containing 2-methylpentane-2,3-diol (MPD). DNA crystals usually take the form either of spherulites up to 100 mu in diameter or of needles with the length up to 50 mu. No irreversible denaturation of DNA occurs during the crystallization process. X-ray diffraction from dense slurries of DNA crystals yields crystalline powder patterns.

  15. Evaluation of three paediatric weight estimation methods in Singapore.

    Science.gov (United States)

    Loo, Pei Ying; Chong, Shu-Ling; Lek, Ngee; Bautista, Dianne; Ng, Kee Chong

    2013-04-01

    Rapid paediatric weight estimation methods in the emergency setting have not been evaluated for South East Asian children. This study aims to assess the accuracy and precision of three such methods in Singapore children: Broselow-Luten (BL) tape, Advanced Paediatric Life Support (APLS) (estimated weight (kg) = 2 (age + 4)) and Luscombe (estimated weight (kg) = 3 (age) + 7) formulae. We recruited 875 patients aged 1-10 years in a Paediatric Emergency Department in Singapore over a 2-month period. For each patient, true weight and height were determined. True height was cross-referenced to the BL tape markings and used to derive estimated weight (virtual BL tape method), while patient's round-down age (in years) was used to derive estimated weights using APLS and Luscombe formulae, respectively. The percentage difference between the true and estimated weights was calculated. For each method, the bias and extent of agreement were quantified using Bland-Altman method (mean percentage difference (MPD) and 95% limits of agreement (LOA)). The proportion of weight estimates within 10% of true weight (p₁₀) was determined. The BL tape method marginally underestimated weights (MPD +0.6%; 95% LOA -26.8% to +28.1%; p₁₀ 58.9%). The APLS formula underestimated weights (MPD +7.6%; 95% LOA -26.5% to +41.7%; p₁₀ 45.7%). The Luscombe formula overestimated weights (MPD -7.4%; 95% LOA -51.0% to +36.2%; p₁₀ 37.7%). Of the three methods we evaluated, the BL tape method provided the most accurate and precise weight estimation for Singapore children. The APLS and Luscombe formulae underestimated and overestimated the children's weights, respectively, and were considerably less precise. © 2013 The Authors. Journal of Paediatrics and Child Health © 2013 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

  16. Optimization of preparation conditions of polyamide thin film composite membrane for organic solvent nanofiltration

    International Nuclear Information System (INIS)

    Namvar-Mahboub, Mahdieh; Pakizeh, Majid

    2014-01-01

    Separation performance of polyamide composite membranes is affected by several parameters during formation of thin upper layer via interfacial polymerization. We investigated the effect of various polyamide synthesis conditions on the performance of organic solvent resistant polyamide composite membranes through the model equations designed by 2-level fractional factorial design. The dewaxing solvent recovery was selected as separation process. Five factors were changed in two level includin; TMC concentration (0.05-0.1%), MPD concentration (1-2%), support immersion time in organic solution (2-4 min), support immersion time in aqueous solution (1-2 min), and curing temperature (70-80 .deg. C). The resultant equations showed 93.48% and 94.82% of the variability (R 2 adj ) in data used to fit oil rejection and permeate flux models, respectively. The analysis of variance revealed that both models were high significant. It was also observed that TMC concentration, MPD concentration and immersion time in TMC have more pronounced effect on the oil rejection and permeate flux than other factors and interactions. Optimal polyamide preparation conditions were obtained using multiple response method for 94% oil rejection as target value. According to the results, the best value of permeate flux (8.86 l/(m 2 ·h)) was found at TMC concentration of 0.1%, MPD concentration of 1.94%, immersion time in TMC of 3.88 min, immersion time in MPD of 1.95 min and curing temperature of 71.96 .deg. C with desirability factor of 1

  17. Preoperative preparation of high-risk, specifically hyperimmunized canine renal allograft recipients with total-lymphoid irradiation and cyclosporine

    International Nuclear Information System (INIS)

    Rapaport, F.T.; Meek, A.G.; Arnold, A.N.; Miura, S.; Hayashi, R.; Strober, S.

    1987-01-01

    Hyperimmunized subjects are a particularly high-risk and rapidly growing group in the patient population awaiting renal transplantation. In a search for methods designed to ameliorate the prognosis in such cases, dogs of defined DLA genotype were sensitized with DLA incompatible skin allografts and injections of buffy coat. Each recipient was challenged with a renal allograft bearing the same DLA incompatibilities. Five dogs received kidney transplants, without any other treatment, and rejected their transplants at 2.5, 4, 5, 6, and 6.5 days, respectively. Another four dogs were given a 9-11-week course (1760 +/- 35 cGy) of total-lymphoid irradiation (TLI), followed by rabbit antithymocyte globulin (ATG); these animals rejected their renal allografts at 7, 8, 14, and 17 days, respectively. Five other dogs were treated with TLI and received cyclosporine (CsA) and methylprednisolone (MPd) daily until graft rejection. Their renal allografts survived for 7.5, 8.5, 20, 62, and 227 days, respectively. Renal allografts placed in normal recipients under the same conditions of donor-recipient DLA incompatibility had a mean survival time of 12.4 days (range: 10-18 days). At the time of transplantation, the specific anti-DLA antibody titers in the recipients were 81 to 243 in the untreated dogs; 27 to 81 in the TLI-ATG-treated group, and 3 to 243 in the TLI-CsA/MPd-treated group. The titers fell within 24-48 hr after renal transplantation, to 3 to 81 in the untreated sensitized dogs; they were 3 to 9 in the TLI-ATG-treated group, and were 9 to 243 in the TLI-CsA/MPd treated group. The cytotoxic antibody titers reached postoperative peaks of 6500 to 200,000 in the untreated dogs; 729 to 6500 in the TLI-ATG-treated dogs, and 243 to 6500 in the TLI-CsA/MPd-treated recipients

  18. The Nuclotron-based Ion Collider Facility Project. The Physics Programme for the Multi-Purpose Detector

    Science.gov (United States)

    Geraksiev, N. S.; MPD Collaboration

    2018-05-01

    The Nuclotron-based Ion Collider fAcility (NICA) is a new accelerator complex being constructed at the Joint Institute for Nuclear Research (JINR). The general objective of the project is to provide beams for the experimental study of hot and dense strongly interacting QCD matter. The heavy ion programme includes two planned detectors: BM@N (Baryonic Matter at Nuclotron) a fixed target experiment with extracted Nuclotron beams; and MPD (MultiPurpose Detector) a collider mode experiment at NICA. The accelerated particles can range from protons and light nuclei to gold ions. Beam energies will span\\sqrt{s}=12-27 GeV with luminosity L ≥ 1 × 1030 cm‑2s‑1 and \\sqrt{{s}NN}=4-11 GeV and average luminosity L = 1 × 1027cm‑2 s ‑1(for 197Au79+), respectively. A third experiment for spin physics is planned with the SPD (Spin Physics Detector) at the NICA collider in polarized beams mode. A brief overview of the MPD is presented along with several observables in the MPD physics programme.

  19. Hemorrhagic and thrombotic complications in patients with myeloproliferative diseases

    Directory of Open Access Journals (Sweden)

    Carla Valladares Vignal

    Full Text Available OBJECTIVE: To correlate the incidence of hemorrhage and thrombosis to bleeding time (BT and platelet aggregation in 27 consecutive patients with myeloproliferative diseases (MPD. DESIGN: Retrospective study. SETTING: Public tertiary referral center. PATIENTS: Eighteen patients with chronic myelogenous leukemia (CML, 5 with polycytemia vera (PV, 2 with essential thrombocytemia (ET and 2 with idiopathic myelofibrosis (MF. Duke's BT and epinephrine-induced platelet aggregation were performed on the patients and on 10 healthy individuals. RESULTS: Eleven patients presented symptoms (41 %: 9 with hemorrhage (33% and 5 with thrombosis (19%.There were less symptomatic patients in the CML group (28% than in the other MPD (67%, without statistical significance (Fisher, p=0.06. Duke's BT was longer in symptomatic patients (Mann-Whitney, p<0.05. Platelet aggregation was abnormal in 7 patients (26% and 71% of them were symptomatic (Fisher, p = 0.07. CONCLUSIONS: The high incidence of bleeding and thrombosis in patients with MPD was related to prolonged BT, but not to platelet aggregation abnormalities.

  20. Performance and stability of Pd nanostructures in an alkaline direct ethanol fuel cell

    Science.gov (United States)

    Carrera-Cerritos, R.; Fuentes-Ramírez, R.; Cuevas-Muñiz, F. M.; Ledesma-García, J.; Arriaga, L. G.

    2014-12-01

    Pd nanopolyhedral, nanobar and nanorod particles were synthesised using the polyol process and evaluated as anodes in a direct ethanol fuel cell. The materials were physico-chemically characterised by high-resolution transmission electronic microscopy (HR-TEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The effect of the operation parameters (i.e., temperature and fuel ethanol concentration) on the maximum power density (MPD) and open circuit voltage (OCV) was investigated. In addition, a stability test was performed by applying three current density steps for fifty cycles. The OCV values increased as the temperature increased for all of the catalysts at low ethanol concentration. Although the MPD increased with temperature for all of the catalyst independent of the ethanol concentration, the effect of the temperature on the MPD for each Pd structure results in different slopes due to the different crystal faces. Finally, a loss of electro-catalytic activity after fifty cycles was observed in all of the catalysts evaluated, which may be in response to morphological changes in the nanostructures.

  1. A novel TFC forward osmosis (FO) membrane supported by polyimide (PI) microporous nanofiber membrane

    Science.gov (United States)

    Chi, Xiang-Yu; Zhang, Ping-Yun; Guo, Xue-Jiao; Xu, Zhen-Liang

    2018-01-01

    A novel interfacial polymerization (IP) procedure on polyimide (PI) microporous nanofiber membrane support with mean pore size 1.27 μm was reported. Using m-phenylenediamine (MPD) as aqueous phase monomer, trimesoyl chloride (TMC) as organic phase monomer, ethanol as aqueous phase co-solvent, thin-film composite (TFC) forward osmosis (FO) membrane was fabricated by two IP procedures. The first IP procedure with the unconventional order (ie, the membrane was immersed in the TMC organic phase first, then in the co-solvent ethanol-water MPD aqueous phase) was used to diminish the pore size of PI microporous nanofiber membrane support for the formation of the polyamide layer. The secondary IP procedure was employed to form the relatively dense polyamide layer with conventional order (ie, the membrane was immersed in the co-solvent ethanol-water MPD aqueous phase first, then in the TMC organic phase). The experimental results showed that higher ethanol concentration led to the relatively higher pure water permeability in RO process and osmotic water flux in FO process, whereas NaCl rejection in RO process decreased and reverse salt flux increased. The specific salt flux (Js/Jv) of TFC FO PI nanofiber membrane (PIN-2-4) could be as low as 0.095 g/L in FO mode. These results could be attributed to influence of the addition of ethanol into aqueous phase on the surface morphology, hydrophilicity and polyamide layer structure.

  2. Time parameterizations and spin supplementary conditions of the Mathisson-Papapetrou-Dixon equations

    Science.gov (United States)

    Lukes-Gerakopoulos, Georgios

    2017-11-01

    The implications of two different time constraints on the Mathisson-Papapetrou-Dixon (MPD) equations are discussed under three spin supplementary conditions (SSCs). For this reason the MPD equations are revisited without specifying the affine parameter and several relations are reintroduced in their general form. The latter allows one to investigate the consequences of combining the Mathisson-Pirani (MP) SSC, the Tulczyjew-Dixon (TD) SSC and the Ohashi-Kyrian-Semerák (OKS) SSC with two affine parameter types: the proper time on one hand and the parameterizations introduced in [Gen. Relativ. Gravit. 8, 197 (1977), 10.1007/BF00763547] on the other. For the MP SSC and the TD SSC it is shown that quantities that are constant of motion for the one affine parameter are not for the other, while for the OKS SSC it is shown that the two affine parameters are the same. To clarify the relation between the two affine parameters in the case of the TD SSC the MPD equations are evolved and discussed.

  3. The relationship of temporomandibular disorders with headaches: a retrospective analysis.

    Science.gov (United States)

    Özkan, Nilüfer Cakir; Ozkan, Fatih

    2011-01-01

    The objective of this study was to retrospectively analyze the incidence of the concurrent existence of temporomandibular disorders (TMD) and headaches. Forty patients (36 female, 4 male, mean age: 29.9±9.6 years) clinically diagnosed with TMD were screened. Patient records were analyzed regarding: range of mouth opening, temporomandibular joint (TMJ) noises, pain on palpation of the TMJ and masticatory muscles and neck and upper back muscles, and magnetic resonance imaging of the TMJ. According to patient records, a total of 40 (66.6%) patients were diagnosed with TMD among 60 patients with headache. Thirty-two (53%) patients had TMJ internal derangement (ID), 8 (13%) patients had only myofascial pain dysfunction (MPD) and 25 (41.6%) patients had concurrent TMJ ID/MPD. There were statistically significant relationships between the number of tender masseter muscles and MPD patients (p=0.04) and between the number of tender medial pterygoid muscles and patients with reducing disc displacement (RDD) (p=0.03). The TMJ and associated orofacial structures should be considered as possible triggering or perpetuating factors for headaches, especially tension-type. There might be a significant connection between TMD and headache. However, most medical and dental practitioners are unaware of this relationship. Therefore, a careful evaluation of the TMJ and associated orofacial structures is required for a correct interpretation of the craniofacial pain in headache patients, and these patients should be managed with a multidisciplinary approach.

  4. Spin glass and ferromagnetic properties of Ce(Cu_1_-_xNi_x)_4Mn alloys: Multicritical points in the magnetic phase diagram

    International Nuclear Information System (INIS)

    Synoradzki, K.; Toliński, T.

    2016-01-01

    We report on the CeNi_4Mn (ferromagnet FM) - CeCu_4Mn (spin-glass SG) transformation leading to a complex magnetic phase diagram (MPD). It is verified that all the Ce(Cu_1_-_xNi_x)_4Mn alloys are isostructural and the transformation is governed only by the Cu-Ni substitution. MPD is built based on the magnetic dc/ac susceptibility measurements and reveals SG formation as well as the region of the coexistence of the FM and SG state in the middle range of the Ni concentration. The complex MPD is explained by clusters formation and a competition of interactions between various crystallographic sites of the hexagonal CaCu_5-type structure, mainly the 3g-3g and 3g-2c interactions. The predominance of the SG state is confirmed by the analysis of the frequency dependence of the ac magnetic susceptibility components and the relaxation of the remanent magnetization. Additionally, the presence of two multicritical points is observed. - Highlights: • We fully characterized the magnetic properties of Ce(Cu_1_-_xNi_x)_4Mn alloys. • We show the presence of complex magnetic behaviour due to atomic-site disorder. • Magnetic phase diagram revels mixed-phase ground state. • Two multicritical points on magnetic phase diagram occurs.

  5. Molecular population dynamics of DNA structures in a bcl-2 promoter sequence is regulated by small molecules and the transcription factor hnRNP LL.

    Science.gov (United States)

    Cui, Yunxi; Koirala, Deepak; Kang, HyunJin; Dhakal, Soma; Yangyuoru, Philip; Hurley, Laurence H; Mao, Hanbin

    2014-05-01

    Minute difference in free energy change of unfolding among structures in an oligonucleotide sequence can lead to a complex population equilibrium, which is rather challenging for ensemble techniques to decipher. Herein, we introduce a new method, molecular population dynamics (MPD), to describe the intricate equilibrium among non-B deoxyribonucleic acid (DNA) structures. Using mechanical unfolding in laser tweezers, we identified six DNA species in a cytosine (C)-rich bcl-2 promoter sequence. Population patterns of these species with and without a small molecule (IMC-76 or IMC-48) or the transcription factor hnRNP LL are compared to reveal the MPD of different species. With a pattern recognition algorithm, we found that IMC-48 and hnRNP LL share 80% similarity in stabilizing i-motifs with 60 s incubation. In contrast, IMC-76 demonstrates an opposite behavior, preferring flexible DNA hairpins. With 120-180 s incubation, IMC-48 and hnRNP LL destabilize i-motifs, which has been previously proposed to activate bcl-2 transcriptions. These results provide strong support, from the population equilibrium perspective, that small molecules and hnRNP LL can modulate bcl-2 transcription through interaction with i-motifs. The excellent agreement with biochemical results firmly validates the MPD analyses, which, we expect, can be widely applicable to investigate complex equilibrium of biomacromolecules. © 2014 The Author(s). Published by Oxford University Press [on behalf of Nucleic Acids Research].

  6. Working conditions and health of personnel dealing with ionizing radiation sources

    International Nuclear Information System (INIS)

    Gus'kova, A.K.

    1978-01-01

    Analyzed are the results of investigations dedicated to evaluation of working and health conditions of personnel engaged at powerful charged-particle accelerators, in the production of radionuclides, different stages of mining and enrichment of pyrochlore ore, maintenance of radio engineering and radio-physical equipment, those engaged on geological and geophysical research, operators of control desks and apparatuses at nuclear reactors. Observation of separate people has been carried out in control groups numbering 200-250 people. It has been found that the annual levels of irradiation doses are not in excess of maximum permissible doses (MPD), however in cases of long work service the total dose amounts to 150 rem (for 15-20 years). Changes in personnel health conditions are analyzed as dependent on the total irradiation dose. Apart from irradiation, the personnel health is also affected by other factors, specifically: unfavorable meteofactors, working regime etc. Specialized medical control was found to be inexpedient for people whose irradiation level was 1/3 of MPD. However for people whose irradiation level ranges from 1/3 to 1 MPD it is advisable to keep the current volume of oriented medical observation. A special attention in this case should be given to control systems, bronchopulmonary system and the state of cutaneous covering depending on the character of irradiation effects. Problems requiring further comprehensive studies are enumerated

  7. Secondary Metabolite Profiles and Mating Populations of Fusarium species in Section Liseola Associated with Bakanae Disease of Rice

    Directory of Open Access Journals (Sweden)

    Nur Ain Izzati, M. Z.

    2008-01-01

    Full Text Available A total of 25 strains of Fusarium species that belong to F. fujikuroi (a pathogen of bakanae disease, F. proliferatum, F. sacchari, F. subglutinans and F. verticillioides were isolated from rice plants showing typical bakanae symptoms in Malaysia and Indonesia and screened for their secondary metabolites. The objectives of the studies were to determine the physiological variability based on production of moniliformin (MON, fumonisin (FB1, gibberellic acid (GA3 and fusaric acid (FA as well as to ascertain the mating populations (MPs within the Gibberella fujikuroi species complex based on their ability to produce perithecia and viable ascospores. Production of GA3 could be used to separate F. fujikuroi that belongs to MP-C from other species. In crosses with seven standard testers of MPs, 76% of strains could be assigned to at least one of the G. fujikuroi species complex namely MP-A (G. moniliformis, MP-B (G. sacchari, MP-C (G. fujikuroi and MP-D (G. intermedia. Single strain (M3237P that was assigned as MP-C, and has also been identified morphologically as F. fujikuroi was also crossed-fertile with MP-D tester. The secondary metabolites profiles and the presence of MP-A, MP-B, MP-C and MP-D strains on samples of bakanae-infected rice plants are new records in Malaysia.

  8. Correlation between macro texture measures carried out by the volumetric method and by different laser texture meter

    International Nuclear Information System (INIS)

    Parra Ruiz, L.; Yanguas Gonzalez, S. J.

    2013-01-01

    The reference value for the measurement of surface macro texture in the Spanish Main Road Network is the MTD or Mean Texture Depth (PMT, Profundidad Media de Textura), obtained by means of the volumetric methods, in accordance with the standard UNE EN 13036-1:12010. The fact that it is a spot measurement that requires road closures makes it an expensive procedure as well as slow and dangerous. In addition to this, the test results are relatively sensitive to the operator, being the procedure not too suitable for systematic surveys. These are some of the reasons that have contributed to the development of texture meter laser devices that can be assembled on board of vehicles, circulating without interfering with the normal traffic flow and providing a parameter named the MPD (Mean Depth Profile). According to the standard UNE-EN ISO 13473-1:2006, it is possible to estimate the texture obtained by volumetric methods, with the parameter ETD (Estimated Texture Depth) through the equation: ETD=0,8 x MPD+0.2 In 2008 CEDEX conducted a study that correlated macro texture measures obtained by means of the volumetric method with such carried out by different laser texture meters. The equations yield a better relation between MPD and MTD were dependent on the measurement device used and were not linear equations type, as is it indicated in the standard, but exponential type equations. (Author) 6 refs.

  9. Evaluation of the International Consensus Guidelines for the Surgical Resection of Intraductal Papillary Mucinous Neoplasms.

    Science.gov (United States)

    Tsukagoshi, Mariko; Araki, Kenichiro; Saito, Fumiyoshi; Kubo, Norio; Watanabe, Akira; Igarashi, Takamichi; Ishii, Norihiro; Yamanaka, Takahiro; Shirabe, Ken; Kuwano, Hiroyuki

    2018-04-01

    International consensus guidelines for intraductal papillary mucinous neoplasms (IPMNs) were revised in 2012. We aimed to evaluate the clinical utility of each predictor in the 2006 and 2012 guidelines and validate the diagnostic value and surgical indications. Forty-two patients with surgically resected IPMNs were included. Each predictor was applied to evaluate its diagnostic value. The 2012 guidelines had greater accuracy for invasive carcinoma than the 2006 guidelines (64.3 vs. 31.0%). Moreover, the accuracy for high-grade dysplasia was also increased (48.6 vs. 77.1%). When the main pancreatic duct (MPD) size ≥8 mm was substituted for MPD size ≥10 mm in the 2012 guidelines, the accuracy for high-grade dysplasia was 80.0%. The 2012 guidelines exhibited increased diagnostic accuracy for invasive IPMN. It is important to consider surgical resection prior to invasive carcinoma, and high-risk stigmata might be a useful diagnostic criterion. Furthermore, MPD size ≥8 mm may be predictive of high-grade dysplasia.

  10. Differential diagnosis of benign and malignant intraductal papillary mucinous tumors of the pancreas: MR cholangiopancreatography and MR angiography

    International Nuclear Information System (INIS)

    Choi, Byung Se; Kim, Tae Kyoung; Kim, Ah Young; Kim, Kyoung Won; Park, Sung Won; Kim, Pyo Nyun; Ha, Kyun Kwon; Lee, Moon Gyu; Kim, Song Cheol

    2003-01-01

    To compare the usefulness of magnetic resonance cholangiopancreatography (MRCP) and MR angiography (MRA) in differentiating malignant from benign intraductal papillary mucinous tumors of the pancreas (IPMTs), and to determine the findings which suggest malignancy. During a 6-year period, 46 patients with IPMT underwent MRCP. Morphologically, tumor type was classified as main duct, branch duct, or combined. The diameter of the main pancreatic duct (MPD), the extent of the dilated MPD, and the location and size of the cystic lesion, septum, and communicating channel were assessed. For all types of IPMTs, enhanced mural nodules and portal vein narrowing were evaluated at MRA. Combined-type IPMTs were more frequently malignant (78%) than benign (42%) (p<0.05). Compared with benign lesions, malignant lesions were larger, and the caliber of the communicating channel was also larger (p < 0.05). Their dilated MPD was more extensive and of greater diameter (p<0.05), and the presence of mural nodules was more frequent (p<0.001). Combined MRCP and MRA might be useful for the differential diagnosis of malignant and benign IPMTs of the pancreas

  11. Post-ERCP pancreatogastric fistula associated with an intraductal papillary-mucinous neoplasm of the pancreas – a case report and literature review

    Directory of Open Access Journals (Sweden)

    Yasuda Yoshikazu

    2005-10-01

    Full Text Available Abstract Background Fistula formation has been reported in intraductal papillary-mucinous neoplasms (IPMNs with or without invasion of the adjacent organs. The presence or absence of invasion is mostly determined by postoperative histological examination rather than by preoperative work-up. Case presentation A 72 year-old Japanese woman showed remarkable dilatation of the main pancreatic duct (MPD in the distal region of the pancreas. Subsequent ERCP also showed MPD dilatation, after which the patient suffered moderate pancreatitis. A subsequent gastroscopy revealed a small ulceration that had not been observed in a gastroscopy performed 3 months prior. Mucinous discharge from the ulceration suggested it might be the orifice of a fistula connected to the MPD. En bloc resection including the distal region of the pancreas, spleen, stomach and part of the transverse colon was performed under the pre- and intraoperative diagnosis of an invasive malignant IPMN. However, histopathology revealed the lesion to be of "borderline malignancy" without apparent invasion of the stomach. Light microscopy showed inflammatory cellular infiltrates (mainly neutrophils around the pancreatogastric fistula, but there was no evidence of neoplastic epithelia lining the fistulous tract. Conclusion This case highlights that a pancreatogastric fistula can develop after acute inflammation of the pancreas in the absence of cancer invasion. Further information regarding IPMN-associated fistulae is necessary to clarify the pathogenesis, diagnosis, appropriate surgical intervention and prognosis for this disorder.

  12. Engineering Pseudomonas putida KT2440 for simultaneous degradation of organophosphates and pyrethroids and its application in bioremediation of soil.

    Science.gov (United States)

    Zuo, Zhenqiang; Gong, Ting; Che, You; Liu, Ruihua; Xu, Ping; Jiang, Hong; Qiao, Chuanling; Song, Cunjiang; Yang, Chao

    2015-06-01

    Agricultural soils are usually co-contaminated with organophosphate (OP) and pyrethroid pesticides. To develop a stable and marker-free Pseudomonas putida for co-expression of two pesticide-degrading enzymes, we constructed a suicide plasmid with expression cassettes containing a constitutive promoter J23119, an OP-degrading gene (mpd), a pyrethroid-hydrolyzing carboxylesterase gene (pytH) that utilizes the upp gene as a counter-selectable marker for upp-deficient P. putida. By introduction of suicide plasmid and two-step homologous recombination, both mpd and pytH genes were integrated into the chromosome of a robust soil bacterium P. putida KT2440 and no selection marker was left on chromosome. Functional expression of mpd and pytH in P. putida KT2440 was demonstrated by Western blot analysis and enzyme activity assays. Degradation experiments with liquid cultures showed that the mixed pesticides including methyl parathion, fenitrothion, chlorpyrifos, permethrin, fenpropathrin, and cypermethrin (0.2 mM each) were degraded completely within 48 h. The inoculation of engineered strain (10(6) cells/g) to soils treated with the above mixed pesticides resulted in a higher degradation rate than in noninoculated soils. All six pesticides could be degraded completely within 15 days in fumigated and nonfumigated soils with inoculation. Theses results highlight the potential of the engineered strain to be used for in situ bioremediation of soils co-contaminated with OP and pyrethroid pesticides.

  13. Correlation between macro texture measures carried out by the volumetric method and by different laser texture meter; Correlacion de medidas de macrotextura tomadas con el metodo volumetrico y con diferentes texturometros lasar

    Energy Technology Data Exchange (ETDEWEB)

    Parra Ruiz, L.; Yanguas Gonzalez, S. J.

    2013-06-01

    The reference value for the measurement of surface macro texture in the Spanish Main Road Network is the MTD or Mean Texture Depth (PMT, Profundidad Media de Textura), obtained by means of the volumetric methods, in accordance with the standard UNE EN 13036-1:12010. The fact that it is a spot measurement that requires road closures makes it an expensive procedure as well as slow and dangerous. In addition to this, the test results are relatively sensitive to the operator, being the procedure not too suitable for systematic surveys. These are some of the reasons that have contributed to the development of texture meter laser devices that can be assembled on board of vehicles, circulating without interfering with the normal traffic flow and providing a parameter named the MPD (Mean Depth Profile). According to the standard UNE-EN ISO 13473-1:2006, it is possible to estimate the texture obtained by volumetric methods, with the parameter ETD (Estimated Texture Depth) through the equation: ETD=0,8 x MPD+0.2 In 2008 CEDEX conducted a study that correlated macro texture measures obtained by means of the volumetric method with such carried out by different laser texture meters. The equations yield a better relation between MPD and MTD were dependent on the measurement device used and were not linear equations type, as is it indicated in the standard, but exponential type equations. (Author) 6 refs.

  14. Differential labeling of platelet alpha 2 adrenoceptors by 3H dihydroergocryptine and 3H yohimbine in patients with myeloproliferative disorders

    International Nuclear Information System (INIS)

    Swart, S.S.; Wood, J.K.; Barnett, D.B.

    1985-01-01

    Platelet alpha adrenoceptor status was examined using the radioligands 3 H-yohimbine ( 3 H-YOH) and 3 H-dihydroergocryptine ( 3 H-DHE) in 14 patients with myeloproliferative disorder (MPD) and 10 normal controls. Platelets from normal controls and MPD patients sensitive to adrenaline induced aggregation exhibited approximately 50% more binding sites identified by 3 H-DHE than 3 H-YOH, whereas MPD platelets insensitive to adrenaline showed selective loss of these extra 3 H-DHE sites. In functional studies after 30 minutes preincubation with the unlabelled antagonists, DHE was more potent than YOH at inhibiting adrenaline induced aggregation in normal platelets. In addition, the affinity constant for DHE was virtually identical in binding and functional experiments, whereas for YOH the affinity constant for binding was approximately 10 fold more potent than that for aggregation. These results suggest that the alpha adrenoceptor binding site on human platelets labelled by 3 H-DHE may be of more functional relevance than that labelled by 3 H-YOH alone

  15. In Patients with a Soft Pancreas, a Thick Parenchyma, a Small Duct, and Fatty Infiltration Are Significant Risks for Pancreatic Fistula After Pancreaticoduodenectomy.

    Science.gov (United States)

    Sugimoto, Motokazu; Takahashi, Shinichiro; Kojima, Motohiro; Kobayashi, Tatsushi; Gotohda, Naoto; Konishi, Masaru

    2017-05-01

    This study sought to characterize soft and hard pancreatic textures radiologically and histologically, and to identify specific risks in a soft pancreas associated with postoperative pancreatic fistula (POPF) formation after pancreaticoduodenectomy (PD). Consecutive 145 patients who underwent PD at a single institution between January 2010 and May 2013 were studied. Pancreatic consistency was intraoperatively judged as soft or hard. Pancreatic configuration was assessed using preoperative CT. Histologic components of the pancreatic stump were evaluated using a morphometric analysis. Clinicopathologic parameters were then analyzed for the risk of clinically relevant POPF. Compared with patients with a hard pancreas (n = 66), those with a soft pancreas (n = 79) had a smaller main pancreatic duct (MPD) diameter and a larger parenchymal thickness on CT, had a smaller fibrosis ratio and a larger lobular ratio histologically, and developed clinically relevant POPF more frequently (P pancreas, an MPD diameter pancreas, a thick parenchyma, a small MPD, and fatty infiltration were strongly associated with clinically relevant POPF after PD.

  16. Catabolism of methyl ter-butyl ether (MTBE): characterization of the enzymes of Mycobacterium austroafricanum IFP 2012 involved in MTBE degradation; Catabolisme du methyl tert-butyl ether (MTBE): caracterisation des enzymes impliquees dans la degradation du MTBE chez Mycobacterium austroafricanum IFP 2012

    Energy Technology Data Exchange (ETDEWEB)

    Lopes Ferreira, N

    2005-11-15

    Methyl tert-butyl ether (MTBE) is added to gasoline to meet the octane index requirement. its solubility in water and its poor biodegradability made the use of MTBE a great environmental concern, particularly regarding aquifers. We previously isolated M austroafricanum IFP 2012 able to use MTBE as a sole source of carbon and energy and the MTBE pathway was partially characterized. In the present study, which aimed at isolating the genes involved in MTBE biodegradation in order to use them for estimation of MTBE biodegradation capacities in contaminated environment, we isolated a new M. austroafricanum strain, IFP 2015. A new degradation intermediate, the 2-methyl 1,2-propane-diol (2-M1,2-PD), the product of tert-butanol (TBA) oxidation, was identified. We also determined the enzymes induced during growth of M. austroafricanum IFP 2012 on MTBF. Then, using the tools of protein analysis and of molecular biology, we isolated and cloned the mpd genes cluster in the plasmid pCL4D. Heterologous expression of the recombinant plasmid in M smegmatis tmc2 155, showed the involvement of an 2-M1,2-PD dehydrogenase (MpdB) and a hydroxy-iso-butyr-aldehyde dehydrogenase (MpdC), encoded by mpdB and mpdC, respectively. Both enzymes were responsible for the conversion of 2-M 1,2-PD to hydroxy-isobutyric acid (HIBA). A further survey of different M austroafricanum strains, including IFP 2012, IFP 2015 and JOBS (ex-M vaccae) showed the link between the ability to grow on C{sub 2} to C{sub 16} n-alkanes and the MTBE and TBA degradation capacities. The alkB gene was partially sequenced in all these strains. Expression of alkB was demonstrated in M. austroafricanum IFP 2012 after growth on propane, hexane, hexadecane and TBA. Finally, we identified 2-propanol as the intermediate of HIBA degradation. The gene encoding the 2-propanol:p-N,N'-dimethyl-4-nitroso-aniline (NDMA) oxidoreductase was detected M austroafricanum IFP 2012. (author)

  17. Malignant pleural disease: diagnosis by using diffusion-weighted and dynamic contrast-enhanced MR imaging--initial experience.

    Science.gov (United States)

    Coolen, Johan; De Keyzer, Frederik; Nafteux, Philippe; De Wever, Walter; Dooms, Christophe; Vansteenkiste, Johan; Roebben, Ilse; Verbeken, Eric; De Leyn, Paul; Van Raemdonck, Dirk; Nackaerts, Kristiaan; Dymarkowski, Steven; Verschakelen, Johny

    2012-06-01

    To investigate the use of diffusion-weighted (DW) imaging for differentiating benign lesions from malignant pleural disease (MPD) and to retrospectively assess dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging acquisitions to find out whether combining these measurements with DW imaging could improve the diagnostic value of DW imaging. This study was approved by the local ethics committee, and all patients provided written informed consent. Thirty-one consecutive patients with pleural abnormalities suspicious for MPD underwent whole-body positron emission tomography (PET)/computed tomography (CT) and thorax MR examinations. Diagnostic thoracoscopy with histopathologic analysis of pleural biopsies served as the reference standard. First-line evaluation of each suspicious lesion was performed by using the apparent diffusion coefficient (ADC) calculated from the DW image, and the optimal cutoff value was found by using receiver operating characteristic curve analysis. Afterward, DCE MR imaging data were used to improve the diagnosis in the range of ADCs where DW imaging results were equivocal. Sensitivity, specificity, and accuracy of PET/CT for diagnosis of MPD were 100%, 35.3%, and 64.5%. The optimal ADC threshold to differentiate benign lesions from MPD with DW MR imaging was 1.52 × 10(-3) mm(2)/sec, with sensitivity, specificity, and accuracy of 71.4%, 100%, and 87.1%, respectively. This result could be improved to 92.8%, 94.1%, and 93.5%, respectively, when DCE MR imaging data were included in those cases where ADC was between 1.52 and 2.00 × 10(-3) mm(2)/sec. A total of 20 patients had disease diagnosed correctly, nine had disease diagnosed incorrectly, and two cases were undetermined with PET/CT. DW imaging helped stage disease correctly in 27 patients and incorrectly in four. The undetermined cases at PET/CT were correctly diagnosed at MR imaging. DW imaging is a promising tool for differentiating MPD from benign lesions, with high

  18. Catabolism of methyl ter-butyl ether (MTBE): characterization of the enzymes of Mycobacterium austroafricanum IFP 2012 involved in MTBE degradation; Catabolisme du methyl tert-butyl ether (MTBE): caracterisation des enzymes impliquees dans la degradation du MTBE chez Mycobacterium austroafricanum IFP 2012

    Energy Technology Data Exchange (ETDEWEB)

    Lopes Ferreira, N.

    2005-11-15

    Methyl tert-butyl ether (MTBE) is added to gasoline to meet the octane index requirement. its solubility in water and its poor biodegradability made the use of MTBE a great environmental concern, particularly regarding aquifers. We previously isolated M austroafricanum IFP 2012 able to use MTBE as a sole source of carbon and energy and the MTBE pathway was partially characterized. In the present study, which aimed at isolating the genes involved in MTBE biodegradation in order to use them for estimation of MTBE biodegradation capacities in contaminated environment, we isolated a new M. austroafricanum strain, IFP 2015. A new degradation intermediate, the 2-methyl 1,2-propane-diol (2-M1,2-PD), the product of tert-butanol (TBA) oxidation, was identified. We also determined the enzymes induced during growth of M. austroafricanum IFP 2012 on MTBF. Then, using the tools of protein analysis and of molecular biology, we isolated and cloned the mpd genes cluster in the plasmid pCL4D. Heterologous expression of the recombinant plasmid in M smegmatis tmc2 155, showed the involvement of an 2-M1,2-PD dehydrogenase (MpdB) and a hydroxy-iso-butyr-aldehyde dehydrogenase (MpdC), encoded by mpdB and mpdC, respectively. Both enzymes were responsible for the conversion of 2-M 1,2-PD to hydroxy-isobutyric acid (HIBA). A further survey of different M austroafricanum strains, including IFP 2012, IFP 2015 and JOBS (ex-M vaccae) showed the link between the ability to grow on C{sub 2} to C{sub 16} n-alkanes and the MTBE and TBA degradation capacities. The alkB gene was partially sequenced in all these strains. Expression of alkB was demonstrated in M. austroafricanum IFP 2012 after growth on propane, hexane, hexadecane and TBA. Finally, we identified 2-propanol as the intermediate of HIBA degradation. The gene encoding the 2-propanol:p-N,N'-dimethyl-4-nitroso-aniline (NDMA) oxidoreductase was detected M austroafricanum IFP 2012. (author)

  19. Wpływ rezonansu stochastycznego na równowagę dziecka z Mózgowym Porażeniem Dziecięcym = Influence of stochastic resonance on body balance of children with Cerebral Palsy

    Directory of Open Access Journals (Sweden)

    Grzegorz Srokowski

    2015-12-01

    • Dzięki zastosowanej terapii polepszył się wynik końcowy w teście równowagi Tinetti, co oznacza zmniejszenie ryzyka upadku u dzieci z MPD.   Słowa klucze: fizjoterapia MPD, rezonans stochastyczny, chód, równowaga.     Abstract Introduction: Cerebral Palsy (CP is an disease with different nonprogressive disorders of Central Nervous System (CNS. They manifest themselves through impairment of motor function and posture. As a result a child by the inability to control in this activities and lack of creation of appropriate postural responses turns them into defensive reactions. It was assumed, that therapy by providing the body with destabilizing stimuli by SRT - Zeptoring have positive impact on equivalent reactions and coordination during walking. The aim of the study was to examine and evaluate the effectiveness of the therapy on the SRT - Zeptoring device called Stochastic Resonance in a group of school children with diagnosed CP. Methods: The study was conducted at the Rehabilitation Center "Neuron" in Małe Gacno during the stationary rehabilitation. The study has covered 15 people, were children and young people with different types of MPD could move alone or with an additional orthopedic. The study included different functional tests, equivalent and an assessment of body postural control. 10 therapies were carried on Stochastic Resonance in accordance with the rules of conduct training on the machine. Results of the study: The detailed results of the study are presented in tables and illustrated on the graphs Conclusions: • Therapy using the stochastic resonance positively affects body posture control. The result is improvement of balance function and gait control in children with CP. • Thanks to the therapy patients has improved the end result of Tinetti balance test, which means a reduction in the risk of falling in children with CP.   Key words: physiotherapy CP, stochastic resonance, gait, balance.

  20. Acute oral administration of low doses of methylphenidate targets calretinin neurons in the rat septal area.

    Directory of Open Access Journals (Sweden)

    Alvaro eGarcía-Aviles

    2015-03-01

    Full Text Available Methylphenidate (MPD is a commonly administered drug to treat children suffering from attention deficit hyperactivity disorder (ADHD. Alterations in septal driven hippocampal theta rhythm may underlie attention deficits observed in these patients. Amongst others, the septo-hippocampal connections have long been acknowledged to be important in preserving hippocampal function. Thus, we wanted to ascertain if methylphenidate administration, which improves attention in patients, could affect septal areas connecting with hippocampus. We used low and orally administered methylphenidate doses (1.3; 2.7 and 5mg/Kg to rats what mimics the dosage range in humans. In our model, we observed no effect when using 1.3mg/Kg methylphenidate; whereas 2.7 and 5 mg/Kg induced a significant increase in c-fos expression specifically in the medial septum, an area intimately connected to the hippocampus. We analyzed dopaminergic areas such as nucleus accumbens and striatum, and found that only 5mg/Kg induced c-fos levels increase. In these areas tyrosine hydroxylase correlated well with c-fos staining, whereas in the medial septum the sparse tyrosine hydroxylase fibres did not overlap with c-fos positive neurons. Double immunofluorescence of c-fos with neuronal markers in the septal area revealed that co-localization with choline acethyl transferase, parvalbumin, and calbindin with c-fos did not change with MPD treatment; whereas, calretinin and c-fos double labeled neurons increased after MPD administration. Altogether, these results suggest that low and acute doses of methylphenidate primary target specific populations of caltretinin medial septal neurons.

  1. Prevalence of Mobile Phone Dependence in Secondary School Adolescents.

    Science.gov (United States)

    Nikhita, Chimatapu Sri; Jadhav, Pradeep R; Ajinkya, Shaunak A

    2015-11-01

    Mobile phones have become an essential part of modern human life. They have many attributes which makes them very attractive to both young and old. There has been an increasing trend of use of mobile phones among students. Data has now started emerging with respect to the negative physical and psychological consequences of excessive use of mobile phones. New research has shown excessive use of mobile phones leading to development of symptoms suggestive of dependence syndrome. To study the prevalence of Mobile Phone Dependence (MPD) in secondary school adolescents. Cross-sectional, observational study conducted in secondary section of English-medium schools at Navi Mumbai (India). Four hundred and fifteen students studying in 8(th), 9(th) and 10(th) standards of schools at Navi Mumbai (India) having personal mobile phone were randomly included in the study. Participant information like age, gender, family type, phone type, duration of use per day and years of mobile phone usage was recorded. They were administered an MPD questionnaire based upon the dependence syndrome criteria as per ICD-10. According to their responses, participants who fulfilled three or more of the diagnostic criteria were rated as having MPD. Mobile Phone Dependence was found in 31.33% of sample students. It was significantly associated with gender (p=0.003, OR=1.91, CI: 1.23-2.99), family type (p=0.0012), type of mobile phone used (pphone (pphone usage (p =0.004, OR=2.4, CI: 1.31-4.55). Mobile Phone Dependence has been found to be an emerging public health problem. There is need to recognize and identify early the growing trends and negative consequences of inappropriate mobile phone use in young users so as to generate awareness, and plan educational and treatment interventions, if need be, so as to prevent a major public health concern.

  2. Use of analyte-modulated modal power distribution in multimode optical fibers for simultaneous single-wavelength evanescent-wave refractometry and spectrometry.

    Science.gov (United States)

    Potyrailo, R A; Ruddy, V P; Hieftje, G M

    1999-11-01

    A new method is described for the simultaneous determination of absorbance and refractive index of a sample medium. The method is based on measurement of the analyte-modulated modal power distribution (MPD) in a multimode waveguide. In turn, the MPD is quantified by the far-field spatial pattern and intensity of light, i.e., the Fraunhofer diffraction pattern (registered on a CCD camera), that emerges from a multimode optical fiber. Operationally, light that is sent down the fiber interacts with the surrounding analyte-containing medium by means of the evanescent wave at the fiber boundary. The light flux in the propagating beam and the internal reflection angles within the fiber are both affected by optical absorption connected with the analyte and by the refractive index of the analyte-containing medium. In turn, these angles are reflected in the angular divergence of the beam as it leaves the fiber. As a result, the Fraunhofer diffraction pattern of that beam yields two parameters that can, together, be used to deduce refractive index and absorbance. This MPD based detection offers important advantages over traditional evanescent-wave detection strategies which rely on recording only the total transmitted optical power or its lost fraction. First, simultaneous determination of sample refractive index and absorbance is possible at a single probe wavelength. Second, the sensitivity of refractometric and absorption measurements can be controlled simply, either by adjusting the distance between the end face of the fiber and the CCD detector or by monitoring selected modal groups at the fiber output. As a demonstration of these capabilities, several weakly absorbing solutions were examined, with refractive indices in the range from 1.3330 to 1.4553 and with absorption coefficients in the range 0-16 cm-1. The new detection strategy is likely to be important in applications in which sample coloration varies and when it is necessary to compensate for variations in the

  3. Focal Pancreatitis Mimicking Pancreatic Mass: Magnetic Resonance Imaging (MRI)/Magnetic Resonance Cholangiopancreatography (MRCP) Findings Including Diffusion-Weighted MRI

    International Nuclear Information System (INIS)

    Momtahen, A.J.; Balci, N.C.; Alkaade, S.; Akduman, E.I.; Burton, F.R.

    2008-01-01

    Background: Focal pancreatitis (FP) is a confined inflammation that mimics a pancreatic mass. Its imaging diagnosis is important to avoid unnecessary procedures. Purpose: To describe the spectrum of magnetic resonance imaging (MRI)/magnetic resonance cholangiopancreatography (MRCP) and diffusion-weighted MRI (DWI) findings of focal pancreatitis mimicking pancreatic masses. Material and Methods: Findings of MRI/MRCP including DWI with a b value of 0 and 600 s/mm2 in 14 patients with pancreatic masses on MRI were retrospectively reviewed and compared to normal pancreas in 14 patients as a control group. Results: FP revealed hypointense signal intensity (SI) (3/14), hypo- to isointense SI (7/14), or isointense SI (4/14) on T1-weighted images, and hypointense SI (1/14), isointense SI (5/14), iso- to hyperintense SI (7/14), or hyperintense SI (1/14) on T2-weighted images compared to remaining pancreas (RP). MRCP images revealed dilatation of the common bile duct (CBD) and main pancreatic duct (MPD) (5/14), dilatation of the MPD only (3/14), dilatation of the CBD only (3/14), and normal MPD and CBD (3/14). Both FP and RP revealed three types of time-signal intensity curves: 1) rapid rise to a peak, with a rapid decline (FP=2, RP=4), 2) slow rise to a peak, followed by a slow decline (FP=5, RP=4), and 3) slower rise to a peak, with a slow decline or plateau (FP=7, RP=6). Mean apparent diffusion coefficient (ADC) values for FP and RP were 2.09±0.18 and 2.03±0.2x10 -3 mm 2 /s, respectively. ADC values of FP and RP revealed no significant difference. Conclusion: The spectrum of imaging findings of focal pancreatitis on MRI/MRCP including DWI was described. Findings of FP were not distinctive as compared to the remaining pancreas

  4. Impact of residual setup error on parotid gland dose in intensity-modulated radiation therapy with or without planning organ-at-risk margin

    International Nuclear Information System (INIS)

    Delana, Anna; Menegotti, Loris; Valentini, Aldo; Bolner, Andrea; Tomio, Luigi; Vanoni, Valentina; Lohr, Frank

    2009-01-01

    Purpose: To estimate the dosimetric impact of residual setup errors on parotid sparing in head-and-neck (H and N) intensity-modulated treatments and to evaluate the effect of employing an PRV (planning organ-at-risk volume) margin for the parotid gland. Patients and methods: Ten patients treated for H and N cancer were considered. A nine-beam intensity-modulated radiotherapy (IMRT) was planned for each patient. A second optimization was performed prescribing dose constraint to the PRV of the parotid gland. Systematic setup errors of 2 mm, 3 mm, and 5 mm were simulated. The dose-volume histograms of the shifted and reference plans were compared with regard to mean parotid gland dose (MPD), normal-tissue complication probability (NTCP), and coverage of the clinical target volume (V 95% and equivalent uniform dose [EUD]); the sensitivity of parotid sparing on setup error was evaluated with a probability-based approach. Results: MPD increased by 3.4%/mm and 3.0%/mm for displacements in the craniocaudal and lateral direction and by 0.7%/mm for displacements in the anterior-posterior direction. The probability to irradiate the parotid with a mean dose > 30 Gy was > 50%, for setup errors in cranial and lateral direction and 95% and EUD variations < 1% and < 1 Gy). Conclusion: The parotid gland is more sensitive to craniocaudal and lateral displacements. A setup error of 2 mm guarantees an MPD ≤ 30 Gy in most cases, without adding a PRV margin. If greater displacements are expected/accepted, an adequate PRV margin could be used to meet the clinical parotid gland constraint of 30 Gy, without affecting target volume coverage. (orig.)

  5. Effect of acidic aqueous solution on chemical and physical properties of polyamide NF membranes

    Science.gov (United States)

    Jun, Byung-Moon; Kim, Su Hwan; Kwak, Sang Kyu; Kwon, Young-Nam

    2018-06-01

    This work was systematically investigated the effects of acidic aqueous solution (15 wt% sulfuric acid as model wastewater from smelting process) on the physical and chemical properties of commercially available nanofiltration (NF) polyamide membranes, using piperazine (PIP)-based NE40/70 membranes and m-phenylene diamine (MPD)-based NE90 membrane. Surface properties of the membranes were studied before and after exposure to strong acid using various analytical tools: Scanning Electron Microscopy (SEM), Attenuated Total Reflectance-Fourier Transform Infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS), contact angle analyzer, and electrophoretic light scattering spectrophotometer. The characterization and permeation results showed piperazine-based NE40/70 membranes have relatively lower acid-resistance than MPD-based NE90 membrane. Furthermore, density functional theory (DFT) calculation was also conducted to reveal the different acid-tolerances between the piperazine-based and MPD-based polyamide membranes. The easiest protonation was found to be the protonation of oxygen in piperazine-based monomer, and the N-protonation of the monomer had the lowest energy barrier in the rate determining step (RDS). The calculations were well compatible with the surface characterization results. In addition, the energy barrier in RDS is highly correlated with the twist angle (τD), which determines the delocalization of electrons between the carbonyl πCO bond and nitrogen lone pair, and the tendency of the twist angle was also maintained in longer molecules (dimer and trimer). This study clearly explained why the semi-aromatic membrane (NE40/70) is chemically less stable than the aromatic membrane (NE90) given the surface characterizations and DFT calculation results.

  6. Bonding in Heavier Group 14 Zero-Valent Complexes-A Combined Maximum Probability Domain and Valence Bond Theory Approach.

    Science.gov (United States)

    Turek, Jan; Braïda, Benoît; De Proft, Frank

    2017-10-17

    The bonding in heavier Group 14 zero-valent complexes of a general formula L 2 E (E=Si-Pb; L=phosphine, N-heterocyclic and acyclic carbene, cyclic tetrylene and carbon monoxide) is probed by combining valence bond (VB) theory and maximum probability domain (MPD) approaches. All studied complexes are initially evaluated on the basis of the structural parameters and the shape of frontier orbitals revealing a bent structural motif and the presence of two lone pairs at the central E atom. For the VB calculations three resonance structures are suggested, representing the "ylidone", "ylidene" and "bent allene" structures, respectively. The influence of both ligands and central atoms on the bonding situation is clearly expressed in different weights of the resonance structures for the particular complexes. In general, the bonding in the studied E 0 compounds, the tetrylones, is best described as a resonating combination of "ylidone" and "ylidene" structures with a minor contribution of the "bent allene" structure. Moreover, the VB calculations allow for a straightforward assessment of the π-backbonding (E→L) stabilization energy. The validity of the suggested resonance model is further confirmed by the complementary MPD calculations focusing on the E lone pair region as well as the E-L bonding region. Likewise, the MPD method reveals a strong influence of the σ-donating and π-accepting properties of the ligand. In particular, either one single domain or two symmetrical domains are found in the lone pair region of the central atom, supporting the predominance of either the "ylidene" or "ylidone" structures having one or two lone pairs at the central atom, respectively. Furthermore, the calculated average populations in the lone pair MPDs correlate very well with the natural bond orbital (NBO) populations, and can be related to the average number of electrons that is backdonated to the ligands. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin.

    Directory of Open Access Journals (Sweden)

    Alexis Dumortier

    2010-02-01

    Full Text Available The Notch pathway is essential for proper epidermal differentiation during embryonic skin development. Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied by a B-lymphoproliferative disease. However, much less is known about the consequences of loss of Notch signaling after birth.To study the function of Notch signaling in the skin of adult mice, we made use of a series of conditional gene targeted mice that allow inactivation of several components of the Notch signaling pathway specifically in the skin. We demonstrate that skin-specific inactivation of Notch1 and Notch2 simultaneously, or RBP-J, induces the development of a severe form of atopic dermatitis (AD, characterized by acanthosis, spongiosis and hyperkeratosis, as well as a massive dermal infiltration of eosinophils and mast cells. Likewise, patients suffering from AD, but not psoriasis or lichen planus, have a marked reduction of Notch receptor expression in the skin. Loss of Notch in keratinocytes induces the production of thymic stromal lymphopoietin (TSLP, a cytokine deeply implicated in the pathogenesis of AD. The AD-like associated inflammation is accompanied by a myeloproliferative disorder (MPD characterized by an increase in immature myeloid populations in the bone marrow and spleen. Transplantation studies revealed that the MPD is cell non-autonomous and caused by dramatic microenvironmental alterations. Genetic studies demontrated that G-CSF mediates the MPD as well as changes in the bone marrow microenvironment leading to osteopenia.Our data demonstrate a critical role for Notch in repressing TSLP production in keratinocytes, thereby maintaining integrity of the skin and the hematopoietic system.

  8. Chronic respiratory disfunction due to diffuse alveolar hemorrhage in patients with systemic lupus erythematosus and primary vasculitis.

    Science.gov (United States)

    Pérez Aceves, Eva; Pérez Cristóbal, Mario; Espinola Reyna, Gerardo A; Ariza Andraca, Raul; Xibille Fridmann, Daniel; Barile Fabris, Leonor A

    2013-01-01

    Pulmonary hemorrhage (PH) occurs in 2-5% of SLE patients, and is associated with a high mortality rate (79-90%). Diagnostic criteria for this complication include: 1) Pulmonary infiltrates, with at least ¾ of lung tissue involved in a chest x ray, 2) Acute respiratory failure, 3) A decrease of 3g/dL or more in hemoglobin levels. PH might lead to organized pneumonia, collagen deposition, and pulmonary fibrosis which in time might cause changes in pulmonary function tests with either restrictive or obstructive patterns. To evaluate the existence of abnormalities in pulmonary function tests after a PH episode. We included patients with SLE and primary vasculitis that developed PH. During the acute episode, we measured SLEDAI in SLE patients, five factor score in microscopic polyangiitis (MPA) and Birmingham Vasculitis Activity Store (BVAS) in granulomatosis with polyangiitis (GPA) (Wegener). We determined the number of PH events, treatment, and ventilator assistance requirements and correlated its association with abnormal pulmonary function tests. We included 10 patients, 7 with SLE, 2 with MPA and 1 with GPA (Wegener). The mean activity measures were: SLEDAI 20.4 ± 7.5, FFS 2, and BVAS 36. Treatment consisted in methylprednisolone (MPD) in 3 patients, MPD plus cyclophosphamide (CY) in 6 patients, and MPD, CY, IV immunoglobulin, and plasmapheresis in one patient. Five patients required ventilatory support. We found abnormalities in pulmonary function tests in 8 patients, three had an obstructive pattern and five a restrictive pattern; 2 patients did not show any change. We did not find a significant association with any of the studied variables. PH might cause abnormalities in pulmonary function tests and prolonged immunosuppressive treatment could be required. Copyright © 2012 Elsevier España, S.L. All rights reserved.

  9. Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, S.; Pathak, M.A.; Fitzpatrick, T.B. [Massachusetts General Hospital, Harvard Medical School, Dept. of Dermatology, Boston, MA (United States); Cuevas, J. [Hospital Universitario de Guadalajara, Dept. of Pathology, Guadalajara (Spain); Villarrubia, V.G. [I.F. Cantabria SA, Medical Dept., Immunology Sect., Madrid (Spain)

    1997-12-31

    Sunburn, immune suppression, photo-aging, and skin cancers result from uncontrolled overexposure of human skin to solar ultraviolet radiation (UVR). Preventive measures, including photo-protection, are helpful and can be achieved by topical sun-screening agents. Polypodium leucotomos (PL) has been used for the treatment of inflammatory diseases and has shown some in vitro and in vivo immunomodulating properties. Its beneficial photo-protective effects in the treatment of vitiligo and its antioxidant properties encouraged us to evaluate in vivo the potentially useful photo-protective property of natural extract of PL after topical application or oral ingestion. Twenty-one healthy volunteers [either untreated or treated with oral psoralens (8-MOP or 5-MOP)] were enrolled in this study and exposed to solar radiation for evaluation of the following clinical parameters: immediate pigment darkening (IPD), minimal erythema dose (MED), minimal melanogenic dose (MMD), and minimal phototoxic dose (MPD) before and after topical or oral administration of PL. Immunohistochemical assessment of CD1a-expressing epidermal cells were also performed. PL was found to be photo-protective after topical application as well as oral administration. PL increased UV dose required for IPD (P<0.01), MED (P<0.001) and MPD (P<0.001). After oral administration of PL, MED increased 2.,8{+-}0.59 times and MPD increased 2.75{+-}0.5 and 6.8{+-}1.3 times depending upon the type of psoralen used. Immunohistochemical study revealed photo-protection of Langherhans cells by oral as well as topical PL. The observed photo-protective activities of oral or topical PL reveal a new avenue in examining the potentially useful field of systemic photo-protection and suggests that PL can be used as adjunct treatment and can make photochemotherapy and phototherapy possibly safe and effective when the control of cutaneous phototoxicity to PUVA or UVB is a limiting factor in such photo-therapies. (au). 50 refs.

  10. Design and construction of a 1-MJ DPF

    International Nuclear Information System (INIS)

    DelMedico, S.; Javedani, J.; Wimmer, R.

    1994-01-01

    A MJ-Class Dense Plasma Focus (DPF) facility, is being designed to develop the technology needed for plasma focus-type magnetoplasmadynamic (MPD) thrusters. The facility will be capable of studying various commercial applications of the plasma focus also, such as soft x-ray lithography. The facility will be located at the University of Illinois, Champaign/Urbana campus. The ultimate objective is to demonstrate the feasibility and attractiveness of the plasma focus MPD concept for very high specific-impulse space propulsion. Studies include scaling experiments up to and including the 1-MJ level and experiments using a gas-injected plasma focus, such as required in the hard vacuum environment of space. The plasma focus thruster differs from the conventional MPD in that it is capable of generating additional thrust from fusion energy released during the pinch phase of the arc run-down. The proposed 1-MJ facility would enable studies of these concepts at a meaningful energy level. If the results are encouraging, as expected, a next step would be to construct a prototype thruster for further studies, including space qualifications. In addition to thruster studies, the MJ-class facility offers considerable flexibility for the study of a variety of scientific applications requiring an intense, pulsed, radiation source. Examples of such uses range from studies of radiation hardening of electronics to transmutation of radioactive wastes. Consequently, upon completion, it is planned to invite outside users to access the MJ-facility in the time that remains after mainline research. A key objective is to establish the DPF facility as a National User's Facility. To accomplish this, it is planned to establish an advisory committee for use of the facility next year and host a workshop for potential users

  11. The influence of biogeographic history on the functional and phylogenetic diversity of passerine birds in savannas and forests of the Brazilian Amazon.

    Science.gov (United States)

    Almeida, Sara Miranda; Juen, Leandro; Sobral, Fernando Landa; Santos, Marcos Pérsio Dantas

    2018-04-01

    Passeriformes is the largest and most diverse avian order in the world and comprises the Passeri and Tyranni suborders. These suborders constitute a monophyletic group, but differ in their ecology and history of occupation of South America. We investigated the influence of biogeographic history on functional and phylogenetic diversities of Passeri and Tyranni in forest and savanna habitats in the Brazilian Amazon. We compiled species composition data for 34 Passeriformes assemblages, 12 in savannas and 22 in forests. We calculated the functional (Rao's quadratic entropy, FD Q ) and phylogenetic diversities (mean pairwise distance, MPD, and mean nearest taxon distance, MNTD), and the functional beta diversity to investigate the potential role of biogeographic history in shaping ecological traits and species lineages of both suborders. The functional diversity of Passeri was higher than for Tyranni in both habitats. The MPD for Tyranni was higher than for Passeri in forests; however, there was no difference between the suborders in savannas. In savannas, Passeri presented higher MNTD than Tyranni, while in forest areas, Tyranni assemblages showed higher MNTD than Passeri. We found a high functional turnover (~75%) between Passeri and Tyranni in both habitats. The high functional diversity of Passeri in both habitats is due to the high diversity of ecological traits exhibited by species of this group, which enables the exploitation of a wide variety of resources and foraging strategies. The higher Tyranni MPD and MNTD in forests is likely due to Tyranni being older settlers in this habitat, resulting in the emergence and persistence of more lineages. The higher Passeri MNTD in savannas can be explained by the existence of a larger number of different Passeri lineages adapted to this severe habitat. The high functional turnover between the suborders in both habitats suggests an ecological strategy to avoid niche overlap.

  12. Chronic caffeine treatment during prepubertal period confers long-term cognitive benefits in adult spontaneously hypertensive rats (SHR), an animal model of attention deficit hyperactivity disorder (ADHD).

    Science.gov (United States)

    Pires, Vanessa A; Pamplona, Fabrício A; Pandolfo, Pablo; Prediger, Rui D S; Takahashi, Reinaldo N

    2010-12-20

    The spontaneously hypertensive rat (SHR) is frequently used as an experimental model for the study of attention deficit hyperactivity disorder (ADHD) since it displays behavioural and neurochemical features of ADHD. Increasing evidence suggests that caffeine might represent an important therapeutic tool for the treatment of ADHD and we recently demonstrated that the acute administration of caffeine improves several learning and memory impairments in adult SHR rats. Here we further evaluated the potential of caffeine in ADHD therapy. Female Wistar (WIS) and SHR rats were treated with caffeine (3mg/kg, i.p.) or methylphenidate (MPD, 2mg/kg, i.p.) for 14 consecutive days during the prepubertal period (post-natal days 25-38) and they were tested later in adulthood in the object-recognition task. WIS rats discriminated all the objects used, whereas SHR were not able to discriminate pairs of objects with subtle structural differences. Chronic treatment with caffeine or MPD improved the object-recognition deficits in SHR rats. Surprisingly, these treatments impaired the short-term object-recognition ability in adult WIS rats. The present drug effects are independent of changes in locomotor activity, arterial blood pressure and body weight in both rat strains. These findings suggest that chronic caffeine treatment during prepubertal period confers long-term cognitive benefits in discriminative learning impairments of SHR, suggesting caffeine as an alternative therapeutic strategy for the early management of ADHD symptoms. Nevertheless, our results also emphasize the importance of a correct diagnosis and the caution in the use of stimulant drugs such as caffeine and MPD during neurodevelopment since they can disrupt discriminative learning in non-ADHD phenotypes. Copyright 2010 Elsevier B.V. All rights reserved.

  13. Clinical significance of magnetic resonance cholangiopancreatography for the diagnosis of cystic tumor of the pancreas compared with endoscopic retrograde cholangiopancreatography and computed tomography

    International Nuclear Information System (INIS)

    Mera, Kiyomi; Tajiri, Hisao; Muto, Manabu

    1999-01-01

    Cystic tumor of the pancreas has been investigated by a variety of imaging techniques. Magnetic resonance cholangiopancreatography (MRCP) is being widely used as a non-invasive diagnostic modality for investigation of the biliary tree and pancreatic duct system. The purpose of this study was to compare MRCP images with those of endoscopic retrograde cholangiopancreatography (ERCP) and computed tomography (CT) in order to clarify the diagnostic efficacy of MRCP for cystic tumor of the pancreas. We retrospectively studied 15 patients with cystic tumor of the pancreas that had been surgically resected and histopathologically confirmed. There were five cases of intraductal papillary adenocarcinoma, five of intraductal papillary adenoma, two of serous cyst adenoma, two of retention cyst associated with invasive ductal adenocarcinoma and one of solid cystic tumor. In all cases MRCP correctly identified the main pancreatic duct (MPD) and showed the entire cystic tumor and the communication between the tumor and the MPD. On the other hand, the detection rate by ERCP of the cystic tumor and the communication between the cystic tumor and the MPD was only 60%. Although the detection rates by CT for the septum and solid components inside the cystic tumor were 100 and 90.0%, respectively, those of MRCP for each were 58.3 and 20.0%. MRCP is capable of providing diagnostic information superior to ERCP for the diagnosis of cystic tumor of the pancreas. Although MRCP may provide complementary information about the whole lesion of interest, the characteristic internal features of cystic tumor of the pancreas should be carefully diagnosed in combination with CT. (author)

  14. HPLC Quantification of Cytotoxic Compounds from Aspergillus niger

    Directory of Open Access Journals (Sweden)

    Paula Karina S. Uchoa

    2017-01-01

    Full Text Available A high-performance liquid chromatography method was developed and validated for the quantification of the cytotoxic compounds produced by a marine strain of Aspergillus niger. The fungus was grown in malt peptone dextrose (MPD, potato dextrose yeast (PDY, and mannitol peptone yeast (MnPY media during 7, 14, 21, and 28 days, and the natural products were identified by standard compounds. The validation parameters obtained were selectivity, linearity (coefficient of correlation > 0.99, precision (relative standard deviation below 5%, and accuracy (recovery > 96.

  15. DapE Can Function as an Aspartyl Peptidase in the Presence of Mn2+

    OpenAIRE

    Broder, Daniel H.; Miller, Charles G.

    2003-01-01

    Extracts of a multiply peptidase-deficient (pepNABDPQTE iadA iaaA) Salmonella enterica serovar Typhimurium strain contain an aspartyl dipeptidase activity that is dependent on Mn2+. Purification of this activity followed by N-terminal sequencing of the protein suggested that the Mn2+-dependent peptidase is DapE (N-succinyl-l,l-diaminopimelate desuccinylase). A dapE chromosomal disruption was constructed and transduced into a multiply peptidase-deficient (MPD) strain. Crude extracts of this st...

  16. Reconstruction of the parameters of V0 particles

    International Nuclear Information System (INIS)

    Ierusalimov, A.P.

    2009-01-01

    The procedure of reconstruction of the parameters of V 0 particles is considered for CBM setup that is planned to build up at the FAIR complex (GSI, Germany). It was shown that the use of various kinematic cuts permits one to improve essentially the selection of V 0 particles and to increase the signal/background ratio. The use of the kinematic fit procedure gives still more considerable improvement of the accuracy of V 0 parameters. The procedure of the selection of Ξ - hyperons is also examined. The considered algorithm can be used practically without changes to reconstruct the parameters of V 0 particles and Ω - /Ξ - hyperons in MPD/NICA

  17. Test and improvement of readout system based on APV25 chip for GEM detector

    International Nuclear Information System (INIS)

    Hu Shouyang; Jian Siyu; Zhou Jing; Shan Chao; Li Xinglong; Li Xia; Li Xiaomei; Zhou Yi

    2014-01-01

    Gas electron multiplier (GEM) is the most promising position sensitive gas detector. The new generation of readout electronics system includes APV25 front-end card, multi-purpose digitizer (MPD), VME controller and Linux-based acquisition software DAQ. The construction and preliminary test of this readout system were finished, and the ideal data with the system working frequency of 40 MHz and 20 MHz were obtained. The long time running test shows that the system has a very good time-stable ability. Through optimizing the software configuration and improving hardware quality, the noise level was reduced, and the signal noise ratio was improved. (authors)

  18. Copolyimide mixed matrix membranes with oriented microporous titanosilicate JDF-L1sheet particles

    OpenAIRE

    Galve, Alejandro; Vispe, Eugenio; Téllez, Carlos; Coronas, Joaquín

    2011-01-01

    JDF-L1 is a microporous titanosilicate exhibiting a layer structure with pore size of about 3 Å. It is consequently an attractive material to separate H2-containing mixtures. This is the reason why JDF-L1, after disaggregation by means of hexadecyltrimethylammonium surfactant, has been combined with a carboxyl group containing copolyimide (6FDA-4MPD/6FDA-DABA 4:1) to produce mixed matrix membranes, which were applied to the separation of H2/CH4 and O2/N2 mixtures. Additionally, due to the she...

  19. Effects of chronic radiation exposure on the reproduction of dogs

    International Nuclear Information System (INIS)

    Shifrine, M.; Kawakami, T.G.; Rasmussen, C.

    1984-01-01

    During studies on radiation leukemogenesis 7 dogs were exposed to 4.4 R/day starting at 150 days of age. Three of these dogs were females. To determine whether the exposure to chronic irradiation affected their reproductive capacity the three bitches were bred. Two of the bitches did not conceive, and one of these died shortly thereafter from myeloproliferative disease (MPD) which could have been a factor. The third bitch whelped 7 pups, one of which died shortly after birth, and the other 6 are healthy 2 months after birth. 1 table

  20. Radiation abuse and its effects

    International Nuclear Information System (INIS)

    Halm, A.

    1976-01-01

    This paper delves into overuse practiced in diagnostic radiography. The conventional attitudes to low-dose irradiation are critically examined, as is the MPD related to individual radiosensitivity. Concern is expressed that a sizeable proportion of radiologists ignore important aspects of the Code of Practice and this attitude is readily emulated in the hospital setting. The author advocates education within the medical profession and the community on the risks involved in radiation abuse and the benefits derived from justified exposures to x rays. (author)

  1. SU-F-T-259: GPR Tables for the Estimation of Mid-Plane Dose Using EPID

    International Nuclear Information System (INIS)

    Annamalai, Gopiraj; Watanabe, Yoichi

    2016-01-01

    Purpose: To develop a simple method for estimating the mid-plane dose (MPD) of a patient using Electronic Portal imaging Device (EPID). Methods: A Varian TrueBeam with aSi100 EPID was used in this study. The EPID images were acquired for a 30 cm × 30 cm homogeneous slab phantom and a 30 cm diameter 20 cm thick cylindrical phantom in the continuous dosimetry mode. The acquired EPID images in XIM format were imported into in-house MATLAB program for the data analysis. First, the dosimetric characteristics of EPID were studied for dose-response linearity, dose-rate dependence, and field size dependence. Next, the average pixels values of the EPID images were correlated with the MPD measured by an ionisation chamber for various thicknesses of the slab phantom (8 cm – 30 cm) and for various square field sizes (3×3 cm 2 – 25×25 cm 2 at the isocenter). Look-up tables called as GPR tables were then generated for both SSD and SAD setup by taking the ratio of MPD measured by the ionisation chamber and the corresponding EPID pixel values. The accuracy of the GPR tables was evaluated by varying the field size, phantom thickness, and wedge angles with the slab and cylindrical phantoms. Results: The dose response of EPID was linear from 20 MU to 300 MU. The EPID response for different dose rates from 40 MU/min to 600 MU/min was within ±1%. The difference in the doses from the GPR tables and the doses measured by the ionization chambers were within 2% for slab phantoms, and 3% for the cylindrical phantom for various field sizes, phantom thickness, and wedge angles. Conclusion: GPR tables are a ready reckoner for in-vivo dosimetry and it can be used to quickly estimate the MPD value from the EPID images with an accuracy of ±3% for common clinical treatment. project work funded by Union for International cancer control(UICC) under ICRETT fellowship

  2. The Use of Tailored Testing with Instructional Programs.

    Science.gov (United States)

    1986-03-01

    AVAILABILITY OF REPORT Approved for public release: distribution un- t~X DWNCADNGSCHiEDULE li-mited. Reproduction in whole or in part is...of Education ,-’ Washington, DC 20V 0 Chicago, IL r06𔄁 Air Force Human Resources Lab Cdt. Arnold Bohrer . AFHRL/MPD Sectie Psychologisch Cnderzoek...University of Texas-Austin Univ-ir-tat Puss-ldorf Measurement and Evalu-,tion Er zi, gswi ssensch;ftl iches Cpnter Un ivf rsit ’tsst r. 1 Austin, TX 787

  3. SU-F-T-259: GPR Tables for the Estimation of Mid-Plane Dose Using EPID

    Energy Technology Data Exchange (ETDEWEB)

    Annamalai, Gopiraj [Government Arignar Anna Memorial Cancer Hospital & Research Institute, Kanchipuram, TAMILNADU (India); Watanabe, Yoichi [University of Minnesota, Minneapolis, MN (United States)

    2016-06-15

    Purpose: To develop a simple method for estimating the mid-plane dose (MPD) of a patient using Electronic Portal imaging Device (EPID). Methods: A Varian TrueBeam with aSi100 EPID was used in this study. The EPID images were acquired for a 30 cm × 30 cm homogeneous slab phantom and a 30 cm diameter 20 cm thick cylindrical phantom in the continuous dosimetry mode. The acquired EPID images in XIM format were imported into in-house MATLAB program for the data analysis. First, the dosimetric characteristics of EPID were studied for dose-response linearity, dose-rate dependence, and field size dependence. Next, the average pixels values of the EPID images were correlated with the MPD measured by an ionisation chamber for various thicknesses of the slab phantom (8 cm – 30 cm) and for various square field sizes (3×3 cm{sup 2} – 25×25 cm{sup 2} at the isocenter). Look-up tables called as GPR tables were then generated for both SSD and SAD setup by taking the ratio of MPD measured by the ionisation chamber and the corresponding EPID pixel values. The accuracy of the GPR tables was evaluated by varying the field size, phantom thickness, and wedge angles with the slab and cylindrical phantoms. Results: The dose response of EPID was linear from 20 MU to 300 MU. The EPID response for different dose rates from 40 MU/min to 600 MU/min was within ±1%. The difference in the doses from the GPR tables and the doses measured by the ionization chambers were within 2% for slab phantoms, and 3% for the cylindrical phantom for various field sizes, phantom thickness, and wedge angles. Conclusion: GPR tables are a ready reckoner for in-vivo dosimetry and it can be used to quickly estimate the MPD value from the EPID images with an accuracy of ±3% for common clinical treatment. project work funded by Union for International cancer control(UICC) under ICRETT fellowship.

  4. Fabrication of Mediatorless/Membraneless Glucose/Oxygen Based Biofuel Cell using Biocatalysts Including Glucose Oxidase and Laccase Enzymes

    Science.gov (United States)

    Christwardana, Marcelinus; Kim, Ki Jae; Kwon, Yongchai

    2016-07-01

    Mediatorless and membraneless enzymatic biofuel cells (EBCs) employing new catalytic structure are fabricated. Regarding anodic catalyst, structure consisting of glucose oxidase (GOx), poly(ethylenimine) (PEI) and carbon nanotube (CNT) is considered, while three cathodic catalysts consist of glutaraldehyde (GA), laccase (Lac), PEI and CNT that are stacked together in different ways. Catalytic activities of the catalysts for glucose oxidation and oxygen reduction reactions (GOR and ORR) are evaluated. As a result, it is confirmed that the catalysts work well for promotion of GOR and ORR. In EBC tests, performances of EBCs including 150 μm-thick membrane are measured as references, while those of membraneless EBCs are measured depending on parameters like glucose flow rate, glucose concentration, distance between two electrodes and electrolyte pH. With the measurements, how the parameters affect EBC performance and their optimal conditions are determined. Based on that, best maximum power density (MPD) of membraneless EBC is 102 ± 5.1 μW · cm-2 with values of 0.5 cc · min-1 (glucose flow rate), 40 mM (glucose concentration), 1 mm (distance between electrodes) and pH 3. When membrane and membraneless EBCs are compared, MPD of the membraneless EBC that is run at the similar operating condition to EBC including membrane is speculated as about 134 μW · cm-2.

  5. Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog

    Directory of Open Access Journals (Sweden)

    Ethan A. Natelson

    2013-01-01

    Full Text Available Myelodysplastic syndromes (MDS are clonal myeloid disorders characterized by progressive peripheral blood cytopenias associated with ineffective myelopoiesis. They are typically considered neoplasms because of frequent genetic aberrations and patient-limited survival with progression to acute myeloid leukemia (AML or death related to the consequences of bone marrow failure including infection, hemorrhage, and iron overload. A progression to AML has always been recognized among the myeloproliferative disorders (MPD but occurs only rarely among those with essential thrombocythemia (ET. Yet, the World Health Organization (WHO has chosen to apply the designation myeloproliferative neoplasms (MPN, for all MPD but has not similarly recommended that all MDS become the myelodysplastic neoplasms (MDN. This apparent dichotomy may reflect the extremely diverse nature of MDS. Moreover, the term MDS is occasionally inappropriately applied to hematologic disorders associated with acquired morphologic myelodysplastic features which may rather represent potentially reversible hematological responses to immune-mediated factors, nutritional deficiency states, and disordered myelopoietic responses to various pharmaceutical, herbal, or other potentially myelotoxic compounds. We emphasize the clinical settings, and the histopathologic features, of such AMD that should trigger a search for a reversible underlying condition that may be nonneoplastic and not MDS.

  6. Probing altered hematopoietic progenitors of preleukemic dogs with JANUS fission neutrons

    International Nuclear Information System (INIS)

    Seed, T.M.; Kaspar, L.V.

    1990-01-01

    Toward the goal of developing basic insights to mechanisms of radiation leukemogenesis, the authors have developed a canine model that responds to protracted courses of low-daily-dose gamma irradiation with high incidences of myeloproliferative disease (MPD), principally myeloid leukemia. Using this model system, the authors have identified and partially characterized a four-phase preclinical sequence in the induction of MPD, including (1) suppression, (2) recovery, (3) accommodation, and (4) preleukemic transition. Further, they have identified within this sequence, a critical early hematopoietic target cell event that appears to promote progression of the initial preclinical phase to the second preclinical phase. This key target cell event is characterized by the acquisition of increased radioresistance to low-LET gamma rays by granulocyte/monocyte-committed progenitors (CFU-GM). In order to gain further insight into the basis of this critical event, the acquired survival responses of preleukemic progenitors have been probed in vitro with high-LET fission neutrons. 23 refs., 4 figs., 1 tab

  7. Role of mannitol metabolism in the pathogenicity of the necrotrophic fungus Alternaria brassicicola

    Directory of Open Access Journals (Sweden)

    Benoit eCalmes

    2013-05-01

    Full Text Available In this study, the physiological functions of fungal mannitol metabolism in the pathogenicity and protection against environmental stresses were investigated in the necrotrophic fungus Alternaria brassicicola. Mannitol metabolism was examined during infection of Brassica oleracea leaves by sequential HPLC quantification of the major soluble carbohydrates and expression analysis of genes encoding two proteins of mannitol metabolism, i.e. a mannitol dehydrogenase (AbMdh, and a mannitol-1-phosphate dehydrogenase (AbMpd. Knockout mutants deficient for AbMdh or AbMpd and a double mutant lacking both enzyme activities were constructed. Their capacity to cope with various oxidative and drought stresses and their pathogenic behaviour were evaluated. Metabolic and gene expression profiling indicated an increase in mannitol production during plant infection. Depending on the mutants, distinct pathogenic processes, such as leaf and silique colonization, sporulation, survival on seeds, were impaired by comparison to the wild-type. This pathogenic alteration could be partly explained by the differential susceptibilities of mutants to oxidative and drought stresses. These results highlight the importance of mannitol metabolism with respect to the ability of A. brassicicola to efficiently accomplish key steps of its pathogenic life cycle.

  8. Pancreaticobiliary duct changes of periampullary carcinomas: Quantitative analysis at MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Dong Sheng, E-mail: victoryhope@163.com [Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041 (China); Department of Radiology, No.4 West China Teaching Hospital of Sichuan University, Chengdu 610041 (China); Chen, Wei Xia, E-mail: wxchen25@126.com [Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041 (China); Wang, Xiao Dong, E-mail: tyfs03yz@163.com [Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041 (China); Acharya, Riwaz, E-mail: riwaz007@hotmail.com [Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041 (China); Jiang, Xing Hua, E-mail: 13881865517@163.com [Department of Pathology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041 (China)

    2012-09-15

    Purpose: To quantitatively analyse the pancreaticobiliary duct changes of periampullary carcinomas with volumetric interpolated breath-hold examination (VIBE) and true fast imaging with steady-state precession (true FISP) sequence, and investigate the value of these findings in differentiation and preoperative evaluation. Materials and methods: Magnetic resonance (MR) images of 71 cases of periampullary carcinomas (34 cases of pancreatic head carcinoma, 16 cases of intrapancreatic bile duct carcinoma and 21 cases of ampullary carcinoma) confirmed histopathologically were analysed. The maximum diameter of the common bile duct (CBD) and main pancreatic duct (MPD), dilated pancreaticobiliary duct angle and the distance from the end of the proximal dilated pancreaticobiliary duct to the major papilla were measured. Analysis of variance and the Chi-squared test were performed. Results: These findings showed significant differences among the three subtypes: the distance from the end of proximal dilated pancreaticobiliary duct to the major papilla and pancreaticobiliary duct angle. The distance and the pancreaticobiliary duct angle were least for ampullary carcinoma among the three subtypes. The percentage of dilated CBD was 94.1%, 93.8%, and 100% for pancreatic head carcinoma, intrapancreatic bile duct carcinoma and ampullary carcinoma, respectively. And that for the dilated MPD was 58.8%, 43.8%, and 42.9%, respectively. Conclusion: Quantitative analysis of the pancreaticobiliary ductal system can provide accurate and objective assessment of the pancreaticobiliary duct changes. Although benefit in differential diagnosis is limited, these findings are valuable in preoperative evaluation for both radical resection and palliative surgery.

  9. Response of fish communities to intense drought in Brazilian savanna streams

    Directory of Open Access Journals (Sweden)

    Dianne Michelle Alves da Silva

    2017-08-01

    Full Text Available The physical structures of streams are subjected to intense changes throughout the seasons. Intense drought in dry periods has been frequent and potentially harmful to aquatic species. In this study, we tested whether the changes in the habitat structure of the streams during the dry period determine the organization of fish communities. Five streams in the Upper Tocantins River were studied in the dry and rainy seasons. The species were characterized by 13 functional traits based on morphological measurements. The descriptors of functional diversity were: mean pairwise functional distance of species in the community (MPD and mean functionally nearest species distance (MNTD. We also calculated the standardized effect size for MPD and MNTD, an indicator of functional redundancy, and compared the observed patterns with those expected by chance. Streams differed between seasons with respect to environmental variables. Functional diversity in the rainy season did not differ from the pattern expected by chance for both metrics. While functional diversity in the dry season has not differed from the pattern expected by chance for SESMPD, a greater functional redundancy for SESMNTD was found in this season. These results indicate that environmental changes in the streams during the dry season are important constraints for fish occurrence, preventing the occurrence of functionally original species. Therefore, a prospective scenario of dry-period intensification could result in functionally redundant communities, with functional homogenization of the regional species pool.

  10. A modified portfolio diet complements medical management to reduce cardiovascular risk factors in diabetic patients with coronary artery disease.

    Science.gov (United States)

    Keith, Mary; Kuliszewski, Michael A; Liao, Christine; Peeva, Valentina; Ahmed, Mavra; Tran, Susan; Sorokin, Kevin; Jenkins, David J; Errett, Lee; Leong-Poi, Howard

    2015-06-01

    Secondary prevention can improve outcomes in high risk patients. This study investigated the magnitude of cardiovascular risk reduction associated with consumption of a modified portfolio diet in parallel with medical management. 30 patients with type II diabetes, 6 weeks post bypass surgery received dietary counseling on a Modified Portfolio Diet (MPD) (low fat, 8 g/1000 kcal viscous fibres, 17 g/1000 kcal soy protein and 22 g/1000 kcal almonds). Lipid profiles, endothelial function and markers of glycemic control, oxidative stress and inflammation were measured at baseline and following two and four weeks of intervention. Seven patients with no diet therapy served as time controls. Consumption of the MPD resulted in a 19% relative reduction in LDL (1.9 ± 0.8 vs 1.6 ± 0.6 mmol/L, p managed, high risk patients resulted in important reductions in risk factors. Clinical Trials registry number NCT00462436. Copyright © 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  11. Annual environmental monitoring report, 1974

    International Nuclear Information System (INIS)

    Stephens, L.D.; Cantelow, H.

    1975-04-01

    The Lawrence Berkeley Laboratory, a large multi-disciplinary research institute, is located in the hills above the University of California and the City of Berkeley. Nuclear Physics and Nuclear Chemistry research are the main contributors to the environmental radiation. In order to pursue this research effort, large particle accelerators have been built and are operated almost continuously. Other research may also involve the use of radioisotopes. These research activities result in a small but finite population dose to the general population which works or resides in the area surrounding the Laboratory. The annual maximum permissible dose equivalent (MPD) for members of the general population is recommended to be 500 mrem, however, Laboratory policy is to keep the population exposure as low as practicable at all times. In order to assure that this is done, several environmental monitoring stations are maintained which continuously telemeter radiation information to a central location. This information is presented here along with studies of the population distribution, in order to provide a total man-rem estimate. Using the data in this report the population dose due to laboratory operation ranges from 0.4 percent to 5.7 percent of the MPD. (U.S.)

  12. Differential diagnosis of groove pancreatic carcinomas vs. groove pancreatitis: Usefulness of the portal venous phase

    International Nuclear Information System (INIS)

    Ishigami, Kousei; Tajima, Tsuyoshi; Nishie, Akihiro; Kakihara, Daisuke; Fujita, Nobuhiro; Asayama, Yoshiki; Ushijima, Yasuhiro; Irie, Hiroyuki; Nakamura, Masafumi; Takahata, Shunichi; Ito, Tetsuhide; Honda, Hiroshi

    2010-01-01

    Purpose: To clarify if the portal venous phase is helpful for the differential diagnosis of groove pancreatic carcinomas and groove pancreatitis. Materials and methods: MDCT and MRI of groove pancreatic carcinomas (n = 7) and groove pancreatitis (n = 15) were retrospectively reviewed by two radiologists independently. The signal intensity on T2-weighted images was subjectively assessed. The presence or absence of common bile duct (CBD) and main pancreatic duct (MPD) strictures, calcifications, and cystic lesions was evaluated. Additionally, the appearance of groove pancreatic carcinoma and that of groove pancreatitis in the portal venous phase on dynamic MDCT and MRI were compared. Results: There were no significant differences in the signal intensity on T2-weighted images and in the presence or absence of CBD and MPD strictures, calcifications, and cystic lesions between groove pancreatic carcinomas and groove pancreatitis. However, patchy focal enhancement in the portal venous phase was more commonly observed in groove pancreatitis than groove pancreatic carcinoma (Reviewers 1 and 2: 14/15 [93.3%] vs. 1/7 [14.3%], P < 0.0001). In addition, peripheral enhancement was only seen in groove pancreatic carcinomas (Reviewer 1: 4/7 [57.1%] vs. 0/15 [0%], P < 0.005, and Reviewer 2: 3/7 [42.9%] vs. 0/15 [0%], P < 0.05). Conclusion: The portal venous phase may be helpful for the differential diagnosis of groove pancreatic carcinomas and groove pancreatitis.

  13. Radiation safety standards

    International Nuclear Information System (INIS)

    1975-01-01

    This is a basic document with which all rules and regulations, etc., concerning protection from ionizing radiations of workers and the general population have to conform. Basic concepts, dimensions, units, and terms used in the area of radiation safety are defined. Radiation exposures are sorted out into three categories: A, to personnel; B, to individual members of the popul;tion; and C, to the general population. Critical organs, furthermore, comprise four groups, the first of them being applicable to the whole-body gonads and bone marrow. Category A maximum permissible dose (MPD) to first group critical organs is 5 rem/year; to second group, 15 rem/year; to thrid group, 3O rem/year; and to fourth group, 75 rem/year. These rate figures include doses from both external and internal radiation exposure. Quality factors needed in computing doses from various types of radiation are provided. Permissible planned exposure levels are specified and guidelines given for accidental exposures. A radiation accident is considered to have occurred if the relevant critical organ dose is 5 times the annual MPD for that organ. For individual members of the population (category B), annual somatic doses to first group critical organs shall not exceed 0,5 rem. Population exposure is controlled in terms of genetically significant dose, which shall not exceed 5 rem/30 years. (G.G.)

  14. Peripheral blood cells from children with RASopathies show enhanced spontaneous colonies growth in vitro and hyperactive RAS signaling

    International Nuclear Information System (INIS)

    Gaipa, G; Bugarin, C; Cianci, P; Sarno, J; Bonaccorso, P; Biondi, A; Selicorni, A

    2015-01-01

    Germline mutations in genes coding for molecules involved in the RAS/RAF/MEK/ERK pathway are the hallmarks of a newly classified family of autosomal dominant syndromes termed RASopathies. Myeloproliferative disorders (MPDs), in particular, juvenile myelomonocytic leukemia, can lead to potentially severe complications in children with Noonan syndrome (NS). We studied 27 children with NS or other RASopathies and 35 age-matched children as control subjects. Peripheral blood (PB) cells from these patients were studied for in vitro colony-forming units (CFUs) activity, as well as for intracellular phosphosignaling. Higher spontaneous growth of both burst-forming units-erythroid (BFU-E) and CFU-granulocyte/macrophage (CFU-GM) colonies from RAS-mutated patients were observed as compared with control subjects. We also observed a significantly higher amount of GM-colony-stimulating factor-induced p-ERK in children with RASopathies. Our findings demonstrate for the first time that PB cells isolated from children suffering from NS or other RASopathies without MPD display enhanced BFU-E and CFU-GM colony formation in vitro. The biological significance of these findings clearly awaits further studies. Collectively, our data provide a basis for further investigating of only partially characterized hematological alterations present in children suffering from RASopathies, and may provide new markers for progression toward malignant MPD in these patients

  15. Partial discharge measurements on 110kV current transformers. Setting the control value. Case study

    Science.gov (United States)

    Dan, C.; Morar, R.

    2017-05-01

    The case study presents a series of partial discharge measurements, reflecting the state of insulation of 110kV CURRENT TRANSFORMERS located in Sibiu county substations. Measurements were performed based on electrical method, using MPD600: an acquisition and analysis toolkit for detecting, recording, and analyzing partial discharges. MPD600 consists of one acquisition unit, an optical interface and a computer with dedicated software. The system allows measurements of partial discharge on site, even in presence of strong electromagnetic interferences because it provides synchronous acquisition from all measurement points. Therefore, measurements, with the ability to be calibrated, do render: - a value subject to interpretation according to IEC 61869-1:2007 + IEC 61869-2:2012 + IEC 61869-3:2011 + IEC 61869-5:2011 and IEC 60270: 2000; - the possibility to determine the quantitative limit of PD (a certain control value) to which the equipment can be operated safely and repaired with minimal costs (relative to the high costs implied by eliminating the consequences of a failure) identified empirically (process in which the instrument transformer subjected to the tests was completely destroyed).

  16. Workload assessment for mental arithmetic tasks using the task-evoked pupillary response

    Directory of Open Access Journals (Sweden)

    Gerhard Marquart

    2015-08-01

    Full Text Available Pupillometry is a promising method for assessing mental workload and could be helpful in the optimization of systems that involve human–computer interaction. The present study focuses on replicating the studies by Ahern (1978 and Klingner (2010, which found that for three levels of difficulty of mental multiplications, the more difficult multiplications yielded larger dilations of the pupil. Using a remote eye tracker, our research expands upon these two previous studies by statistically testing for each 1.5 s interval of the calculation period (1 the mean absolute pupil diameter (MPD, (2 the mean pupil diameter change (MPDC with respect to the pupil diameter during the pre-stimulus accommodation period, and (3 the mean pupil diameter change rate (MPDCR. An additional novelty of our research is that we compared the pupil diameter measures with a self-report measure of workload, the NASA Task Load Index (NASA-TLX, and with the mean blink rate (MBR. The results showed that the findings of Ahern and Klingner were replicated, and that the MPD and MPDC discriminated just as well between the lowest and highest difficulty levels as did the NASA-TLX. The MBR, on the other hand, did not differentiate between the difficulty levels. Moderate to strong correlations were found between the MPDC and the proportion of incorrect responses, indicating that the MPDC was higher for participants with a poorer performance. For practical applications, validity could be improved by combining pupillometry with other physiological techniques.

  17. A highly active hybrid catalyst modified (La0.60Sr0.40)0.95Co0.20Fe0.80O3-δ cathode for proton conducting solid oxide fuel cells

    Science.gov (United States)

    Lei, Libin; Tao, Zetian; Hong, Tao; Wang, Xiaoming; Chen, Fanglin

    2018-06-01

    The sluggish reaction kinetics in the cathode usually leads to considerable cathode polarization resistance, hindering the development of proton conducting solid oxide fuel cells (H-SOFCs) operated at intermediate temperatures (400-650 °C). To address this problem, for the first time, a novel hybrid catalyst consisting of PrNi0.5Mn0.5O3 and PrOx is impregnated in the (La0.60Sr0.40)0.95Co0.20Fe0.80O3-δ (LSCF) cathode of H-SOFCs, resulting in significant enhancement of the cathode reaction kinetics. Single cells with impregnated LSCF cathode and BaZr0.8Y0.2O3 (BZY) electrolyte yield a maximum power density (MPD) of 0.198 W cm-2 at 600 °C, more than doubled of that with blank LSCF cathode (0.083 W cm-2). ECR and EIS studies reveal that the hybrid catalyst can substantially accelerate the oxygen-ion transfer and oxygen dissociation-absorption processes in the cathode, resulting in significantly lower polarization resistance and higher MPD. In addition, the hybrid catalyst possesses good chemical and microstructural stability at 600 °C. Consequently, the single cells with impregnated LSCF cathode show excellent durability. This study shows that the impregnation of this novel hybrid catalyst in the cathode could be a promising approach to improve the performance and stability of H-SOFCs.

  18. A simulated plasma disruption experiment using a magneto-plasma-dynamic arcjet

    International Nuclear Information System (INIS)

    Madarame, H.; Sukegawa, T.; Okamoto, K.

    1991-01-01

    If a melt layer is expelled by a strong electromagnetic force from some places during a plasma disruption, the wall thickness is reduced there remarkably. Although this phenomenon is considered as a very important issue, it has not been studied so far because of its difficulty and complexity. In this study, the phenomenon was simulated using a magneto-plasma-dynamic (MPD) arcjet. The MPD arcjet was used as both a heat source and an electric current source. The current flowed radially in a stainless steel test piece installed in a transverse magnetic field. The circumferential electromagnetic force generated a swirl flow in the melt layer, causing a centrifugal force, which thinned the central part of the round region and formed a circular embankment on the fringe. A numerical code was developed which could calculate the melting, the evaporation and the melt layer movement by the centrifugal force and the beam pressure. The calculational results on the melting depth and the thickness reduction in the central part were compared with experiment. (orig.)

  19. Exchange of equipment between CERN and JINR

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    The drift chambers of the former NA48 experiment have recently left CERN to be installed in the MPD experiment at the future NICA accelerator in Dubna, Russia. As a counterpart, the JINR Laboratory will produce drift chambers for the new NA62 experiment. This operation is a fruitful exchange of technology that profits both laboratories and enhances their collaboration.   On 22 July, in the occasion of the departure of the chambers from CERN, Mikhail Itkis (centre), acting Director of the JIINR visited the NA62 experimental area accompanied by Rolf Heuer (left), CERN Director General and Ferdinand Hahn, NA62 technical Co-ordinator. The NA48 drift chambers were overhauled in 2000 and employed until 2008. With a total of 110 kilometres of wire soldered to a very high degree of precision, the four drift chambers were a crucial element of the experimental kaon programme at CERN. The chambers are now moving to a new challenge as they will be re-used by the Multi Purpose Detector (MPD) experiment, under...

  20. Space experiments with particle accelerators: SEPAC

    International Nuclear Information System (INIS)

    Obayashi, T.

    1978-01-01

    In this paper, the program of the space experiments with particle accelerators (SEPAC) is described. The SEPAC is to be prepared for the Space Shuttle/First Spacelab Mission. It is planned in the SEPAC to carry out the active and interactive experiments on and in the Earth's ionosphere and magnetosphere. It is also intended to make an initial performance test for the overall program of Spacelab/SEPAC experiments. The instruments to be used are electron beam accelerators, MPD arcjects, and associated diagnostic equipments. The main scientific objectives of the experiments are Vehicle Charge Neutralization, Beam Plasma Physics, and Beam Atmosphere Interactions. The SEPAC system consists of the following subsystems. Those are accelerators, monitoring and diagnostic equipments, and control and data management equipments. The SEPAC functional objectives for experiment operations are SEPAC system checkout, EBA firing test, MPD firing test, electron beam experiments, plasma beam propagation, artificial aurora excitation, equatorial aerochemistry, electron echo experiment, E parallel B experiment, passive experiments, SEPAC system deactivation, and battery charging. Most experiment procedures are carried out by the pre-set computer program. (Kato, T.)

  1. TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations.

    Science.gov (United States)

    Pardanani, A; Hood, J; Lasho, T; Levine, R L; Martin, M B; Noronha, G; Finke, C; Mak, C C; Mesa, R; Zhu, H; Soll, R; Gilliland, D G; Tefferi, A

    2007-08-01

    JAK2V617F and MPLW515L/K represent recently identified mutations in myeloproliferative disorders (MPD) that cause dysregulated JAK-STAT signaling, which is implicated in MPD pathogenesis. We developed TG101209, an orally bioavailable small molecule that potently inhibits JAK2 (IC(50)=6 nM), FLT3 (IC(50)=25 nM) and RET (IC(50)=17 nM) kinases, with significantly less activity against other tyrosine kinases including JAK3 (IC(50)=169 nM). TG101209 inhibited growth of Ba/F3 cells expressing JAK2V617F or MPLW515L mutations with an IC(50) of approximately 200 nM. In a human JAK2V617F-expressing acute myeloid leukemia cell line, TG101209-induced cell cycle arrest and apoptosis, and inhibited phosphorylation of JAK2V617F, STAT5 and STAT3. Therapeutic efficacy of TG101209 was demonstrated in a nude mouse model. Furthermore, TG101209 suppressed growth of hematopoietic colonies from primary progenitor cells harboring JAK2V617F or MPL515 mutations.

  2. Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders.

    Science.gov (United States)

    Gery, Sigal; Gueller, Saskia; Chumakova, Katya; Kawamata, Norihiko; Liu, Liqin; Koeffler, H Phillip

    2007-11-01

    Recently, activating myeloproliferative leukemia virus oncogene (MPL) mutations, MPLW515L/K, were described in myeloproliferative disorder (MPD) patients. MPLW515L leads to activation of downstream signaling pathways and cytokine-independent proliferation in hematopoietic cells. The adaptor protein Lnk is a negative regulator of several cytokine receptors, including MPL. We show that overexpression of Lnk in Ba/F3-MPLW515L cells inhibits cytokine-independent growth, while suppression of Lnk in UT7-MPLW515L cells enhances proliferation. Lnk blocks the activation of Jak2, Stat3, Erk, and Akt in these cells. Furthermore, MPLW515L-expressing cells are more susceptible to Lnk inhibitory functions than their MPL wild-type (MPLWT)-expressing counterparts. Lnk associates with activated MPLWT and MPLW515L and colocalizes with the receptors at the plasma membrane. The SH2 domain of Lnk is essential for its binding and for its down-regulation of MPLWT and MPLW515L. Lnk itself is tyrosine-phosphorylated following thrombopoietin stimulation. Further elucidating the cellular pathways that attenuate MPLW515L will provide insight into the pathogenesis of MPD and could help develop specific therapeutic approaches.

  3. [MPLW515L point mutation in patients with myeloproliferative disease].

    Science.gov (United States)

    Xia, Jun; Xu, Wei; Zhang, Su-Jiang; Fan, Lei; Qiao, Chun; Li, Jian-Yong

    2008-12-01

    In order to investigate the frequency of MPLW515L and JAK2V617F point mutations of the patients with myeloproliferative disease (MPD) in Nanjing area, MPLW515L and JAK2V617F point mutations were simultaneously detected by alleles specific polymerase chain reaction (AS-PCR) and sequencing in 190 MPD patients. The results showed that MPLW515L point mutation was detected in 1 out of 102 essential thrombocythemia (ET) patients (1.0%) and was not detected in 32 polycythemia vera (PV) patients, 13 idiopathic myelofibrosis (IMF) patients, 43 chronic myelogenous leukemia (CML) patients. JAK2V617F point mutation was detected in 20 out of 32 PV patients (62.5%), 43 out of 102 ET patients (42.2%), 5 out of 13 IMF patients (38.5%), and was not detected in 43 CML patients. It is concluded that MPLW515L point mutation exists in ET patient, but is not found in PV, IMF and CML. JAK2V617F point mutation exists in PV, ET and IMF, but not in CML.

  4. Surfactive stabilization of multi-walled carbon nanotube dispersions with dissolved humic substances

    Energy Technology Data Exchange (ETDEWEB)

    Chappell, Mark A. [Environmental Laboratory, Engineering Research and Development Center, US Army Corps of Engineers, 3909 Halls Ferry Road, Vicksburg, MS 39180 (United States)], E-mail: mark.a.chappell@usace.army.mil; George, Aaron J.; Dontsova, Katerina M.; Porter, Beth E. [SpecPro, Inc., 4815 Bradford Drive, Suite 201, Huntsville, AL 35805 (United States); Price, Cynthia L. [Environmental Laboratory, Engineering Research and Development Center, US Army Corps of Engineers, 3909 Halls Ferry Road, Vicksburg, MS 39180 (United States); Zhou Pingheng; Morikawa, Eizi [J. Bennett Johnston Sr. Center for Advanced Microstructures and Devices, Louisiana State University, 6980 Jefferson Highway, Baton Rouge, LA 70806 (United States); Kennedy, Alan J.; Steevens, Jeffery A. [Environmental Laboratory, Engineering Research and Development Center, US Army Corps of Engineers, 3909 Halls Ferry Road, Vicksburg, MS 39180 (United States)

    2009-04-15

    Soil humic substances (HS) stabilize carbon nanotube (CNT) dispersions, a mechanism we hypothesized arose from the surfactive nature of HS. Experiments dispersing multi-walled CNT in solutions of dissolved Aldrich humic acid (HA) or water-extractable Catlin soil HS demonstrated enhanced stability at 150 and 300 mg L{sup -1} added Aldrich HA and Catlin HS, respectively, corresponding with decreased CNT mean particle diameter (MPD) and polydispersivity (PD) of 250 nm and 0.3 for Aldrich HA and 450 nm and 0.35 for Catlin HS. Analogous trends in MPD and PD were observed with addition of the surfactants Brij 35, Triton X-405, and SDS, corresponding to surfactant sorption maximum. NEXAFS characterization showed that Aldrich HA contained highly surfactive domains while Catlin soil possessed a mostly carbohydrate-based structure. This work demonstrates that the chemical structure of humic materials in natural waters is directly linked to their surfactive ability to disperse CNT released into the environment. - Suspensions of multi-walled carbon nanotubes are stabilized by relatively low concentrations of dissolved humic substances in solution through surfactive mechanisms.

  5. Microplasmas for chemical analysis: analytical tools or research toys?

    International Nuclear Information System (INIS)

    Karanassios, Vassili

    2004-01-01

    An overview of the activities of the research groups that have been involved in fabrication, development and characterization of microplasmas for chemical analysis over the last few years is presented. Microplasmas covered include: miniature inductively coupled plasmas (ICPs); capacitively coupled plasmas (CCPs); microwave-induced plasmas (MIPs); a dielectric barrier discharge (DBD); microhollow cathode discharge (MCHD) or microstructure electrode (MSE) discharges, other microglow discharges (such as those formed between 'liquid' electrodes); microplasmas formed in micrometer-diameter capillary tubes for gas chromatography (GC) or high-performance liquid chromatography (HPLC) applications, and a stabilized capacitive plasma (SCP) for GC applications. Sample introduction into microplasmas, in particular, into a microplasma device (MPD), battery operation of a MPD and of a mini- in-torch vaporization (ITV) microsample introduction system for MPDs, and questions of microplasma portability for use on site (e.g., in the field) are also briefly addressed using examples of current research. To emphasize the significance of sample introduction into microplasmas, some previously unpublished results from the author's laboratory have also been included. And an overall assessment of the state-of-the-art of analytical microplasma research is provided

  6. Satanism, ritual abuse, and multiple personality disorder: a sociohistorical perspective.

    Science.gov (United States)

    Mulhern, S

    1994-10-01

    During the past decade in North America, a growing number of mental health professionals have reported that between 25% and 50% of their patients in treatment for multiple personality disorder (MPD) have recovered early childhood traumatic memories of ritual torture, incestuous rape, sexual debauchery, sacrificial murder, infanticide, and cannibalism perpetrated by members of clandestine satanic cults. Although hundreds of local and federal police investigations have failed to corroborate patients' therapeutically constructed accounts, because the satanic etiology of MPD is logically coherent with the neodissociative, traumatic theory of psychopathology, conspiracy theory has emerged as the nucleus of a consistent pattern of contemporary clinical interpretation. Resolutely logical and thoroughly operational, ultrascientific psychodemonology remains paradoxically oblivious to its own irrational premises. When the hermetic logic of conspiracy theory is stripped away by historical and socio/psychological analysis, however, the hypothetical perpetrators of satanic ritual abuse simply disappear, leaving in their wake the very real human suffering of all those who have been caught up in the social delusion.

  7. Age-related changes in normal adult pancreas: MR imaging evaluation

    International Nuclear Information System (INIS)

    Sato, Tomohiro; Ito, Katsuyoshi; Tamada, Tsutomu; Sone, Teruki; Noda, Yasufumi; Higaki, Atsushi; Kanki, Akihiko; Tanimoto, Daigo; Higashi, Hiroki

    2012-01-01

    Objective: To investigate age-related changes in normal adult pancreas as identified by magnetic resonance imaging (MRI). Materials and methods: We examined 115 patients without pancreatic diseases (21–90 years) who underwent upper abdominal MRI to evaluate the normal pancreatic MRI findings related to aging. The parameters examined were the pancreatic anteroposterior (AP) diameter, pancreatic lobulation, pancreatic signal intensity (SI), depiction of the main pancreatic duct (MPD), grade of the visual SI decrease on the opposed-phase T1-weighted images compared with in-phase images, and enhancement effect of the pancreas in the arterial phase of dynamic imaging. Results: The pancreatic AP diameter significantly reduced (head, p = 0.0172; body, p = 0.0007; tail, p < 0.0001), and lobulation (p < 0.0001) and parenchymal fatty change (p < 0.0001) became more evident with aging. No significant correlation was observed between aging and pancreatic SI, however the SI on the in-phase T1-weighted images tended to decrease with aging. No significant correlation was observed between aging and the depiction of the MPD as well as aging and contrast enhancement. Conclusion: MRI findings of pancreatic atrophy, lobulation, and fatty degeneration are characteristic changes related to aging, and it is necessary to recognize these changes in the interpretation of abdominal MRI in patients with and without pancreatic disease

  8. Simulation of reaction diffusion processes over biologically relevant size and time scales using multi-GPU workstations.

    Science.gov (United States)

    Hallock, Michael J; Stone, John E; Roberts, Elijah; Fry, Corey; Luthey-Schulten, Zaida

    2014-05-01

    Simulation of in vivo cellular processes with the reaction-diffusion master equation (RDME) is a computationally expensive task. Our previous software enabled simulation of inhomogeneous biochemical systems for small bacteria over long time scales using the MPD-RDME method on a single GPU. Simulations of larger eukaryotic systems exceed the on-board memory capacity of individual GPUs, and long time simulations of modest-sized cells such as yeast are impractical on a single GPU. We present a new multi-GPU parallel implementation of the MPD-RDME method based on a spatial decomposition approach that supports dynamic load balancing for workstations containing GPUs of varying performance and memory capacity. We take advantage of high-performance features of CUDA for peer-to-peer GPU memory transfers and evaluate the performance of our algorithms on state-of-the-art GPU devices. We present parallel e ciency and performance results for simulations using multiple GPUs as system size, particle counts, and number of reactions grow. We also demonstrate multi-GPU performance in simulations of the Min protein system in E. coli . Moreover, our multi-GPU decomposition and load balancing approach can be generalized to other lattice-based problems.

  9. Low frequency of c-MPL gene mutations in Iranian patients with Philadelphia-negative myeloproliferative disorders.

    Science.gov (United States)

    Ghotaslou, A; Nadali, F; Chahardouli, B; Alizad Ghandforosh, N; Rostami, S H; Alimoghaddam, K; Ghavamzadeh, A

    2015-01-01

    Myeloproliferative disorders are a group of diseases characterized by increased proliferation of myeloid lineage. In addition to JAK2V617F mutation, several mutations in the c-MPL gene have been reported in patients with philadelphia-negative chronic myeloproliferative disorders that could be important in the pathogenesis of diseases. The aim of the present study was to investigate the frequency of c-MPL and JAK2V617F mutations in Iranian patients with Philadelphia-negativemyeloproliferative disorders. Peripheral blood samples were collected from 60 patients with Philadelphia-negative MPD) Subgroups ET and PMF) and 25 healthy subjects as control group. The mutation status of c-MPL and Jak2V617F were investigated by using Amplification-refractory mutation system (ARMS) and Allele-Specific PCR (AS-PCR), respectively. The results were confirmed by sequencing. Among 60 patients, 34 (56.6%) and 1(1.7%) had Jak2V617F and c-MPL mutation, respectively. Patients with Jak2V617F mutation had higher WBC counts and hemoglobin concentration than those without the mutation (p= 0.005, p=0.003). In addition, for all healthy subjects in control group, mutations were negative. The present study revealed that the c-MPL mutations unlike the Jak2V617F mutations are rare in Iranian patients with Ph-negative MPNs and the low mutation rate should be considered in the design of screening strategies of MPD patients.

  10. Autosomal dominant distal myopathy: Linkage to chromosome 14

    Energy Technology Data Exchange (ETDEWEB)

    Laing, N.G.; Laing, B.A.; Wilton, S.D.; Dorosz, S.; Mastaglia, F.L.; Kakulas, B.A. [Australian Neuromuscular Research Institute, Perth (Australia); Robbins, P.; Meredith, C.; Honeyman, K.; Kozman, H.

    1995-02-01

    We have studied a family segregating a form of autosomal dominant distal myopathy (MIM 160500) and containing nine living affected individuals. The myopathy in this family is closest in clinical phenotype to that first described by Gowers in 1902. A search for linkage was conducted using microsatellite, VNTR, and RFLP markers. In total, 92 markers on all 22 autosomes were run. Positive linkage was obtained with 14 of 15 markers tested on chromosome 14, with little indication of linkage elsewhere in the genome. Maximum two-point LOD scores of 2.60 at recombination fraction .00 were obtained for the markers MYH7 and D14S64 - the family structure precludes a two-point LOD score {ge} 3. Recombinations with D14S72 and D14S49 indicate that this distal myopathy locus, MPD1, should lie between these markers. A multipoint analysis assuming 100% penetrance and using the markers D14S72, D14S50, MYH7, D14S64, D14S54, and D14S49 gave a LOD score of exactly 3 at MYH7. Analysis at a penetrance of 80% gave a LOD score of 2.8 at this marker. This probable localization of a gene for distal myopathy, MPD1, on chromosome 14 should allow other investigators studying distal myopathy families to test this region for linkage in other types of the disease, to confirm linkage or to demonstrate the likely genetic heterogeneity. 24 refs., 3 figs., 1 tab.

  11. Wavelength-selective bleaching of the optical spectra of trapped electrons in organic glasses. II

    International Nuclear Information System (INIS)

    Paraszczak, J.; Willard, J.E.

    1979-01-01

    Further resolution of the inhomogeneous optical spectra of trapped electrons (e - /sub t/) in organic glasses has been obtained from wavelength selective bleaching and thermal decay studies on 3-methylpentane-d 14 (3MP-d 14 ) and 2-methyltetrahydrofuran (MTHF) following γ irradiation in the temperature region of 20 K, and limits on the degree of resolution achievable have been indicated. Exposure of 3MP-d 14 to light of wavelengths >2100 nm (from a tunable laser) reduces the optical densities at the bleaching wavelength and longer to zero, while ''peeling off'' a portion of the O.D. at all shorter wavelengths but leaving the remainder of the spectrum unaffected. The fraction of the integrated optical spectrum, ∫OD d (eV), removed by bleaching at each wavelength tested, and also by thermal decay, is equivalent to the fraction of the total e - /sub t/ spins removed and measured by ESR. 1064 nm light bleaches the spectrum nearly uniformly, confirming that the spectra of all of the e - /sub t/ have blue tails with similar ease of bleaching. Heretofore unobserved low temperature thermal decay of e - /sub t/ occurs at 20 and 40 K (20% of the spin concentration in 30 min, 35% in 3h). The rate of decay of the optical spectrum decreases with decreasing wavelength of observation (2.5, 2.2, 1.8, and 1.5 μ), but at each wavelength is the same at 40 K as at 20 K, consistent

  12. Predictive factors for exocrine pancreatic insufficiency after pancreatoduodenectomy with pancreaticogastrostomy.

    Science.gov (United States)

    Nakamura, Hiroyuki; Murakami, Yoshiaki; Uemura, Kenichiro; Hayashidani, Yasuo; Sudo, Takeshi; Ohge, Hiroki; Sueda, Taijiro

    2009-07-01

    The aim of this study was to determine risk factors for exocrine pancreatic insufficiency after pancreatoduodenectomy (PD) with pancreaticogastrostomy (PG). A (13)C-labeled mixed triglyceride breath test was performed in 61 patients after PD to assess exocrine pancreatic function. Percent (13)CO(2) cumulative dose at 7 h pancreatic insufficiency. Abdominal computed tomography scans were utilized to assess the dilatation of the main pancreatic duct (MPD dilatation) in the remnant. Thirty-eight of 61 patients (62.3%) were diagnosed with exocrine pancreatic insufficiency. Univariate analysis identified significant associations between two preoperative factors (preoperative impaired endocrine function and a hard pancreatic texture induced by preexisting obstructive pancreatitis), plus one postoperative factor (MPD dilatation caused by PG stricture) and exocrine pancreatic insufficiency (P pancreatic insufficiency after PD may be partly explainable by preexisting obstructive pancreatitis prior to surgery, surgeons desiring to obtain better postoperative exocrine pancreatic function after PD would be well-advised to devote considerable attention to preventing PG stricture.

  13. Robotic Enucleation for Benign or Borderline Tumours of the Pancreas: A Retrospective Analysis and Comparison from a High-Volume Centre in Asia.

    Science.gov (United States)

    Jin, Jia-Bin; Qin, Kai; Li, Hua; Wu, Zhi-Chong; Zhan, Qian; Deng, Xia-Xing; Chen, Hao; Shen, Bai-Yong; Peng, Cheng-Hong; Li, Hong-Wei

    2016-12-01

    Enucleation is increasingly performed for benign or borderline tumours of the pancreas because it is a parenchyma-sparing and less invasive procedure compared to conventional pancreatectomy, which reduces the risk of exocrine and endocrine insufficiency. This study retrospectively evaluated and compared the pre-, intra-, and post-operative clinical characteristics after open and robotic approaches for pancreatic enucleation. Fifty-six cases of enucleation for benign or borderline tumours of the pancreas treated from March 2010 to July 2015 were identified by a retrospective search. These included 25 patients who underwent an open approach and 31 patients who underwent a robotic approach. The clinical characteristics were extracted and compared. The two groups had a similar location and pathology of the tumour. The robotic group had a significantly shorter operation time and significantly less blood loss than the open group. The rates of clinical pancreatic fistula (PF) formation and major complications were similar. The robotic approach could be applied for a tumour on the right side of the pancreas without increasing the incidence of clinical PF or other major complications. The patients with clinical PF had a significantly shorter distance between the lesion and the main pancreatic duct (MPD). Robotic enucleation appears to be a feasible and safe approach for benign or borderline tumours of the pancreas and was associated with similarly favourable surgical outcomes as the open approach. Identifying and avoiding the MPD is an important step during enucleation.

  14. Nuclear matter physics at NICA

    Energy Technology Data Exchange (ETDEWEB)

    Senger, P. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany)

    2016-08-15

    The exploration of the QCD phase diagram is one of the most exciting and challenging projects of modern nuclear physics. In particular, the investigation of nuclear matter at high baryon densities offers the opportunity to find characteristic structures such as a first-order phase transition with a region of phase coexistence and a critical endpoint. The experimental discovery of these prominent landmarks of the QCD phase diagram would be a major breakthrough in our understanding of the properties of nuclear matter. Equally important is the quantitative experimental information on the properties of hadrons in dense matter which may shed light on chiral symmetry restoration and the origin of hadron masses. Worldwide, substantial efforts at the major heavy-ion accelerators are devoted to the clarification of these fundamental questions, and new dedicated experiments are planned at future facilities like CBM at FAIR in Darmstadt and MPD at NICA/JINR in Dubna. In this article the perspectives for MPD at NICA will be discussed. (orig.)

  15. Modern Shale Gas Horizontal Drilling: Review of Best Practices for Exploration Phase Planning and Execution

    Institute of Scientific and Technical Information of China (English)

    Nathaniel Harding; Stephen Smith; John Shelton; Mike D. Bumaman

    2009-01-01

    The challenging characteristics of shale formations often require horizontal drilling to economically develop their potential. While every shale gas play is unique, there are several best practices for the proper planning and execution of a horizontal well. In planning a horizontal well, the optimal method and technology for building inclination and extending the lateral section must be determined. Properly specified logging-while-drilling tools are essential to keep the wellbore within the target formation. Planning must also focus on casing design. Doing so will help ensure stability and enable reliable and productive completions. Shales pose a challenge for these elements of well planning due to their thin strata and potentially low mechanical competence when foreign fluids are introduced. Once a plan is developed, executing it is even more important to prove a viable exploration program. Fast, efficient drilling with wellbore control and minimal torque and drag should be the priority. This may be achieved by focusing on fluid hydraulics and rheology and bottom hole assembly. Managed pressure drilling (MPD) will help fast drilling, well control and stability. If MPD can be combined with new generation rotary steerable systems that allow the drill string to maintain rotation, impressive efficiencies are possible. Modern drilling parameter analysis represents the newest opportunity for executing shale gas horizontal wells. A method for ROP analysis to improve operational parameters and equipment selection is also proposed.

  16. Negative symptom subgroups have different effects on the clinical course of schizophrenia after the first episode: a 24-month follow up study.

    Science.gov (United States)

    Ergül, C; Üçok, A

    2015-01-01

    The aim of this study was to assess the factor structure of negative symptoms in first-episode schizophrenia (FES), and to examine the relationship of these factors with clinical course and functioning of patients during the two-year follow up. We assessed 174 drug-naïve patients with FES using Brief Psychiatric Rating Scale-Expanded (BPRS), Scale for the Assessment of Negative Symptoms (SANS), Scale for the Assessment of Positive Symptoms (SAPS), and Global Assessment of Functioning (GAF) and a cognitive battery at admission. The scales were repeated monthly during follow up. We recorded the patients' functioning levels, remission, and work status after 12 and 24 months. A two-factor structure was found at the baseline, whereas one factor was found after 12 and 24 months. Expressive deficit (ED) factor consisted of alogia and blunted affect, and motivation-pleasure deficit (MPD) factor consisted of avolition and anhedonia. ED factor was related to earlier onset and remission, and it was negatively correlated with duration of education and cognitive test scores. MPD factor was related to duration of untreated psychosis, family history of schizophrenia, and work status, and it appeared as the only independent variable that contributed to the baseline GAF score in linear regression analysis. Our findings suggest that the factors have different aetiologies and impacts on the clinical course of schizophrenia and functioning after FES. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  17. Thin Film Polyamide Membranes with Photoresponsive Antibacterial Activity

    KAUST Repository

    Duong, Phuoc H. H.

    2017-08-09

    Membranes containing a photosensitizer molecule as part of the selective layer are proposed with demonstrated anti-biofouling activity. For the membrane preparation, mixtures of an amine-functionalized photosensitizer molecule, (5,10,15,20-(tetra-4-aminophenyl)porphyrin) and m-phenylene diamine (MPD) reacted with trimesoyl chloride (TMC) by interfacial polymerization to form thin polyamide films on top of an asymmetric porous support. A highly permeable membrane (35.4 Lm−2h−1bar−1) with 99 % rejection of Brilliant Blue R (826 g/mol) was obtained using 0.25 wt% porphyrin and 0.75 wt% MPD as amine monomers. Under visible light exposure, singlet oxygen (1O2) is generated in the porphyrin containing-polyamide film, reaching the bacteria in the feed by diffusion and enhancing the biofouling resistance and anti-microbial activity. Anti-biofouling and anti-microbial photoactivity in solution are demonstrated on Staphylococcus aureus at different porphyrin concentrations and light exposure time.

  18. Physical inactivity and associated factors among women from a municipality in southern Brazil.

    Science.gov (United States)

    Marcellino, Cristiano; Henn, Ruth Liane; Olinto, Maria Teresa; Bressan, Ana Weigert; Paniz, Vera Maria; Pattussi, Marcos Pascoal

    2014-05-01

    Physical inactivity is one of the most important modifiable risk factors that is raising the global burden of chronic diseases. This is a cross-sectional, population-based study of 790 women aged 20 years or older living in the urban area of a municipality in Southern Brazil. The level of physical activity was measured using the International Physical Activity Questionnaire, short form. Inactivity was defined as fewer than 150 min/wk-1 spent in moderate or vigorous physical activities. Prevalence ratios were calculated by robust Poisson regression. The prevalence of physical inactivity was 48.7% (95% CI, 43.3%-54.1%). After adjusting for confounders, we found a linear trend for increasing prevalence of physical inactivity with increasing body mass index (P = .008). Women who were married or in a domestic partnership were 29% less physically active than single women (P = .044). A borderline association was detected between the presence of minor psychiatric disorders (MPD) and physical inactivity (P = .058). There was a high prevalence of inactivity. Obese women, those married or in domestic partnerships and those with MPD were more likely to lead an inactive lifestyle. These results suggest that strategies are required for breaking down barriers to physical activity in this demographic group.

  19. Co-occurrence of hypertrophic cardiomyopathy and myeloproliferative disorder in a neonate with Noonan syndrome carrying Thr73Ile mutation in PTPN11.

    Science.gov (United States)

    Yagasaki, Hideaki; Nakane, Takaya; Hasebe, Youhei; Watanabe, Atsushi; Kise, Hiroaki; Toda, Takako; Koizumi, Keiichi; Hoshiai, Minako; Sugita, Kanji

    2015-12-01

    Most cases of Noonan syndrome (NS) result from mutations in one of the RAS-MAPK signaling genes, including PTPN11, SOS1, KRAS, NRAS, RAF1, BRAF, SHOC2, MEK1 (MAP2K1), and CBL. Cardiovascular diseases of varying severity, such as pulmonary stenosis and hypertrophic cardiomyopathy (HCM), are common in NS patients. RAF1 mutations are most frequent in NS with HCM, while PTPN11 mutations are also well known. Thr73Ile is a gain-of-function mutation of PTPN11, which has been highly associated with juvenile myelomonocytic leukemia and NS/myeloproliferative disease (MPD), but has not previously been reported in HCM. Here, we report a Japanese female infant with NS carrying the PTPN11 T73I mutation with NS/MPD, complete atrio-ventricular septal defect, and rapidly progressive HCM. No other HCM-related mutations were detected in PTPN11, RAF1, KRAS, BRAF, and SHOC2. This patient provides additional information regarding the genotype-phenotype correlation for PTPN11 T73I mutation in NS. © 2015 Wiley Periodicals, Inc.

  20. Radiation shield analysis for a manned Mars rover

    International Nuclear Information System (INIS)

    Morley, N.J.; ElGenk, M.S.

    1991-01-01

    Radiation shielding for unmanned space missions has been extensively studied; however, designs of man-rated shields are minimal. Engle et al.'s analysis of a man-rated, multilayered shield composed of two and three cycles (a cycle consists of a tungsten and a lithium hydride layer) is the basis for the work reported in this paper. The authors present the results of a recent study of shield designs for a manned Mars rover powered by a 500-kW(thermal) nuclear reactor. A train-type rover vehicle was developed, which consists of four cars and is powered by an SP-100-type nuclear reactor heat source. The maximum permissible dose rate (MPD) from all sources is given by the National Council on Radiation Protection and Measurements as 500 mSv/yr (50 rem/yr) A 3-yr Mars mission (2-yr round trip and 1-yr stay) will deliver a 1-Sv natural radiation dose without a solar particle event, 450 mSv/yr in flight, and an additional 100 mSv on the planet surface. An anomalously large solar particle event could increase the natural radiation dose for unshielded astronauts on the Martian surface to 200 mSv. This limits the MPD to crew members from the nuclear reactor to 300 mSv

  1. Chronic radiation-induced leukemogenesis: alterations of hematopoietic progenitor repair functions during preclinical phases

    International Nuclear Information System (INIS)

    Seed, T.M.; Kaspar, L.V.; Grdina, D.J.; Frazier, M.E.

    1987-01-01

    Chronic exposure to low daily doses of whole-body gamma irradiation elicits a high incidence of myeloid leukemia (ML) and related myeloproliferative diseases (MPD) in beagles. Previously, the authors identified and partially characterized a four-phase sequence of evolving MPD as a consequence of chronic radiation exposure. With a focus on preclinical alterations in granulocyte/monocyte-committed stem cells, they have identified two critical events in the process: (i) an early event, involving the coupling of acquired radioresistance of the stem cell with renewed proliferative capacity; and (ii) a late event, involving acquired autocrine functions and associated change in stem cell clonality. In terms of the early event, repair-associated parameters are currently being examined on the cellular level by both split-dose and low dose-rate-type assays with survival enhancement used as the measured end point. On the molecular level, these parameters are examined by microfluorometric alkaline elution assays with DNA damage and repair used as end points

  2. Green Modification of Outer Selective P84 Nanofiltration (NF) Hollow Fiber Membranes for Cadmium Removal

    KAUST Repository

    Gao, Jie

    2015-10-26

    Outer-selective thin-film composite (TFC) hollow fiber membranes are normally made from interfacial polymerization of m-phenylenediamine (MPD) and trimesoyl chloride (TMC). However, the removal of excess MPD solution and the large consumption of alkane solvents are their technical bottlenecks. In this study, green methods to prepare the outer selective TFC hollow fiber membranes were explored by firstly modifying the membrane substrate with polyethyleneimine (PEI) and then by water soluble small molecules such as glutaraldehyde (GA) and epichlorohydrin (ECH). Using P84 polyimide as the substrate, not only do these modifications decrease substrate\\'s pore size, but also vary surface charge by making the membranes less positively charged. As a result, the resultant membranes have higher rejections against salts such as Na2SO4, NaCl and MgSO4. The PEI and then GA modified membrane has the best separation performance with a NaCl rejection over 90% and a pure water permeability (PWP) of 1.74±0.01 Lm−2bar−1h−1. It also shows an impressive rejection to CdCl2 (94%) during long-term stability tests. The CdCl2 rejection remains higher than 90% at operating temperatures from 5 to 60 °C. This study may provide useful insights for green manufacturing of outer-selective nanofiltration (NF) hollow fiber membranes.

  3. Thin Film Polyamide Membranes with Photoresponsive Antibacterial Activity

    KAUST Repository

    Duong, Phuoc H. H.; Hong, Pei-Ying; Musteata, Valentina-Elena; Peinemann, Klaus-Viktor; Nunes, Suzana Pereira

    2017-01-01

    Membranes containing a photosensitizer molecule as part of the selective layer are proposed with demonstrated anti-biofouling activity. For the membrane preparation, mixtures of an amine-functionalized photosensitizer molecule, (5,10,15,20-(tetra-4-aminophenyl)porphyrin) and m-phenylene diamine (MPD) reacted with trimesoyl chloride (TMC) by interfacial polymerization to form thin polyamide films on top of an asymmetric porous support. A highly permeable membrane (35.4 Lm−2h−1bar−1) with 99 % rejection of Brilliant Blue R (826 g/mol) was obtained using 0.25 wt% porphyrin and 0.75 wt% MPD as amine monomers. Under visible light exposure, singlet oxygen (1O2) is generated in the porphyrin containing-polyamide film, reaching the bacteria in the feed by diffusion and enhancing the biofouling resistance and anti-microbial activity. Anti-biofouling and anti-microbial photoactivity in solution are demonstrated on Staphylococcus aureus at different porphyrin concentrations and light exposure time.

  4. Mass savings domain of plasma propulsion for LEO to GEO transfer

    International Nuclear Information System (INIS)

    Choueiri, E.Y.; Kelly, A.J.; Jahn, R.G.

    1993-01-01

    A parametric model is used to study the mass savings of plasma propulsion over advanced chemical propulsion for lower earth orbit (LEO) to geosynchronous orbit (GEO) transfer. Such savings are characterized by stringent requirements of massive payloads (O(10) metric tons) and high power levels (O(100) kW). Mass savings on the order of the payload mass are possible but at the expense of longer transfer times (8--20 months). Typical of the savings domain is the case of a self-field magnetoplasmadynamic (MPD) thruster running quasi-steadily, at an I s of 2000 s, with 600 kW of input power, raising a 50 metric ton satellite in 270 days. The initial mass at LEO will be 65 tons less than a 155 ton LO 2 /LH 2 advanced chemical high thrust spacecraft. An optimum I s can only be found if the cost savings associated with mass savings are counterbalanced by the cost losses incurred by longer transfer times. A simplistic cost model that illustrates the overall trends in the optimization yielded an optimum I s of about 2200 s for a cost effective baseline MPD system

  5. Protracted radiation-induced alterations in hematopoietic repair and recovery

    International Nuclear Information System (INIS)

    Seed, T.M.; Fritz, T.E.

    1997-01-01

    Pathologic predisposition of beagle dogs under chronic, low daily dose (7.5 cGy day -1 ) whole-body gamma irradiation has been studied relative to molecular repair and hematopoietic competency. Molecular repair, assessed by a microscopy-based unscheduled DNA synthesis (UDS) response, was measured within proliferative and nonproliferative marrow myeloid elements of dogs with markedly different hematopoietic capacities (low capacity, aplasia-prone [AA + ] versus high capacity, myeloproliferative disease-prone [MPD + ]) under protracted radiation stress. Results indicated that protracted exposure elicited a net increase in UDS-repair capacity that was largely independent of exposure duration. This enhanced capacity resulted from the increased strength of the UDS signal together with an expanded number of positively responding cells. The combined response was strong in primitive blasts and weak in more differentiated myelocytic cells. The UDS repair response of the MPD + dogs was significantly greater than that of the AA + animals and was clearly modified relative to the controls. These results suggest that both resiliency and pathologic potential of the hematopoietic system under protracted radiation stress is, in part, associated with an augmentable DNA repair within the more primitive myeloid marrow elements. (author)

  6. Surfactive stabilization of multi-walled carbon nanotube dispersions with dissolved humic substances

    International Nuclear Information System (INIS)

    Chappell, Mark A.; George, Aaron J.; Dontsova, Katerina M.; Porter, Beth E.; Price, Cynthia L.; Zhou Pingheng; Morikawa, Eizi; Kennedy, Alan J.; Steevens, Jeffery A.

    2009-01-01

    Soil humic substances (HS) stabilize carbon nanotube (CNT) dispersions, a mechanism we hypothesized arose from the surfactive nature of HS. Experiments dispersing multi-walled CNT in solutions of dissolved Aldrich humic acid (HA) or water-extractable Catlin soil HS demonstrated enhanced stability at 150 and 300 mg L -1 added Aldrich HA and Catlin HS, respectively, corresponding with decreased CNT mean particle diameter (MPD) and polydispersivity (PD) of 250 nm and 0.3 for Aldrich HA and 450 nm and 0.35 for Catlin HS. Analogous trends in MPD and PD were observed with addition of the surfactants Brij 35, Triton X-405, and SDS, corresponding to surfactant sorption maximum. NEXAFS characterization showed that Aldrich HA contained highly surfactive domains while Catlin soil possessed a mostly carbohydrate-based structure. This work demonstrates that the chemical structure of humic materials in natural waters is directly linked to their surfactive ability to disperse CNT released into the environment. - Suspensions of multi-walled carbon nanotubes are stabilized by relatively low concentrations of dissolved humic substances in solution through surfactive mechanisms

  7. Development and validation of a stochastic model for potential growth of Listeria monocytogenes in naturally contaminated lightly preserved seafood.

    Science.gov (United States)

    Mejlholm, Ole; Bøknæs, Niels; Dalgaard, Paw

    2015-02-01

    A new stochastic model for the simultaneous growth of Listeria monocytogenes and lactic acid bacteria (LAB) was developed and validated on data from naturally contaminated samples of cold-smoked Greenland halibut (CSGH) and cold-smoked salmon (CSS). During industrial processing these samples were added acetic and/or lactic acids. The stochastic model was developed from an existing deterministic model including the effect of 12 environmental parameters and microbial interaction (O. Mejlholm and P. Dalgaard, Food Microbiology, submitted for publication). Observed maximum population density (MPD) values of L. monocytogenes in naturally contaminated samples of CSGH and CSS were accurately predicted by the stochastic model based on measured variability in product characteristics and storage conditions. Results comparable to those from the stochastic model were obtained, when product characteristics of the least and most preserved sample of CSGH and CSS were used as input for the existing deterministic model. For both modelling approaches, it was shown that lag time and the effect of microbial interaction needs to be included to accurately predict MPD values of L. monocytogenes. Addition of organic acids to CSGH and CSS was confirmed as a suitable mitigation strategy against the risk of growth by L. monocytogenes as both types of products were in compliance with the EU regulation on ready-to-eat foods. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. Predictors of Post-Operative Pain Relief in Patients with Chronic Pancreatitis Undergoing the Frey or Whipple Procedure.

    Science.gov (United States)

    Sinha, Amitasha; Patel, Yuval A; Cruise, Michael; Matsukuma, Karen; Zaheer, Atif; Afghani, Elham; Yadav, Dhiraj; Makary, Martin A; Hirose, Kenzo; Andersen, Dana K; Singh, Vikesh K

    2016-04-01

    Post-operative pain relief in chronic pancreatitis (CP) is variable. Our objective was to determine clinical imaging or histopathologic predictor(s) of post-operative pain relief in CP patients undergoing the Whipple or Frey procedure. All patients who underwent a Whipple (n = 30) or Frey procedure (n = 30) for painful CP between January 2003 and September 2013 were evaluated. A toxic etiology was defined as a history of alcohol use and/or smoking. The pre-operative abdominal CT was evaluated for calcification(s) and main pancreatic duct (MPD) dilation (≥5 mm). The post-operative histopathology was evaluated for severe fibrosis. Clinical imaging and histopathologic features were evaluated as predictors of post-operative pain relief using univariable and multivariable regression analysis. A total of 60 patients (age 51.6 years, 53% males) were included in our study, of whom 42 (70%) reported post-operative pain relief over a mean follow-up of 1.1 years. There were 37 (62%) patients with toxic etiology, 36 (60%) each with calcification(s) and MPD dilation. A toxic etiology, calcifications, and severe fibrosis were associated with post-operative pain relief on univariable analysis (all p Whipple or Frey procedure.

  9. An accurate estimation and optimization of bottom hole back pressure in managed pressure drilling

    Directory of Open Access Journals (Sweden)

    Boniface Aleruchi ORIJI

    2017-06-01

    Full Text Available Managed Pressure Drilling (MPD utilizes a method of applying back pressure to compensate for wellbore pressure losses during drilling. Using a single rheological (Annular Frictional Pressure Losses, AFPL model to estimate the backpressure in MPD operations for all sections of the well may not yield the best result. Each section of the hole was therefore treated independently in this study as data from a case study well were used. As the backpressure is a function of hydrostatic pressure, pore pressure and AFPL, three AFPL models (Bingham plastic, Power law and Herschel Bulkley models were utilized in estimating the backpressure. The estimated backpressure values were compared to the actual field backpressure values in order to obtain the optimum backpressure at the various well depths. The backpressure values estimated by utilizing the power law AFPL model gave the best result for the 12 1/4" hole section (average error % of 1.855% while the back pressures estimated by utilizing the Herschel Bulkley AFPL model gave the best result for the 8 1/2" hole section (average error % of 12.3%. The study showed that for hole sections of turbulent annular flow, the power law AFPL model fits best for estimating the required backpressure while for hole sections of laminar annular flow, the Herschel Bulkley AFPL model fits best for estimating the required backpressure.

  10. Precision medicine for hepatocelluar carcinoma using molecular pattern diagnostics: results from a preclinical pilot study.

    Science.gov (United States)

    Agarwal, Rahul; Cao, Yuan; Hoffmeier, Klaus; Krezdorn, Nicolas; Jost, Lukas; Meisel, Alejandro Rodriguez; Jüngling, Ruth; Dituri, Francesco; Mancarella, Serena; Rotter, Björn; Winter, Peter; Giannelli, Gianluigi

    2017-06-08

    The aim of this study was to design a road map for personalizing cancer therapy in hepatocellular carcinoma (HCC) by using molecular pattern diagnostics. As an exploratory study, we investigated molecular patterns of tissues of two tumors from individual HCC patients, which in previous experiments had shown contrasting reactions to the phase 2 transforming growth factor beta receptor 1 inhibitor galunisertib. Cancer-driving molecular patterns encompass - inter alias - altered transcription profiles and somatic mutations in coding regions differentiating tumors from their respective peritumoral tissues and from each other. Massive analysis of cDNA ends and all-exome sequencing demonstrate a highly divergent transcriptional and mutational landscape, respectively, for the two tumors, that offers potential explanations for the tumors contrasting responses to galunisertib. Molecular pattern diagnostics (MPDs) suggest alternative, individual-tumor-specific therapies, which in both cases deviate from the standard sorafenib treatment and from each other. Suggested personalized therapies use kinase inhibitors and immune-focused drugs as well as low-toxicity natural compounds identified using an advanced bioinformatics routine included in the MPD protocol. The MPD pipeline we describe here for the prediction of suitable drugs for treatment of two contrasting HCCs may serve as a blueprint for the design of therapies for various types of cancer.

  11. Comparison of dose length, area, and volume histograms as quantifiers of urethral dose in prostate brachytherapy

    International Nuclear Information System (INIS)

    Butler, Wayne M.; Merrick, Gregory S.; Dorsey, Anthony T.; Hagedorn, Brenda M.

    2000-01-01

    Purpose: To determine the magnitude of the differences between urethral dose-volume, dose-area, and dose-length histograms (DVH, DAH, and DLH, respectively, or DgH generically). Methods and Materials: Six consecutive iodine-125 ( 125 I) patients and 6 consecutive palladium-103 ( 103 Pd) patients implanted via a modified uniform planning approach were evaluated with day 0 computed tomography (CT)-based dosimetry. The urethra was identified by the presence of a urinary catheter and was hand drawn on the CT images with a mean radius of 3.3 ± 0.7 mm. A 0.1-mm calculation matrix was employed for the urethral volume and surface analysis, and urethral dose points were placed at the centroid of the urethra on each 5-mm CT slice. Results: Although individual patient DLHs were step-like, due to the sparseness of the data points, the composite urethral DLH, DAH, and DVHs were qualitatively similar. The DAH curve delivered more radiation than the other two curves at all doses greater than 90% of the prescribed minimum peripheral dose (mPD) to the prostate. In addition, the DVH curve was consistently higher than the DLH curve at most points throughout that range. Differences between the DgH curves were analyzed by integrating the difference curves between 0 and 200% of the mPD. The area-length, area-volume, and volume-length difference curves integrated in the ratio of 3:2:1. The differences were most pronounced near the inflection point of the DgH curves with mean A 125 , V 125 , and L 125 values of 36.6%, 31.4%, and 23.0%, respectively, of the urethra. Quantifiers of urethral hot spots such as D 10 , defined as the minimal dose delivered to the hottest 10% of the urethra, followed the same ranking: area analysis indicated the highest dose and length analysis, the lowest dose. D 10 was 148% and 136% of mPD for area and length evaluations, respectively. Comparing the two isotopes in terms of the amount of urethra receiving a given dose, 103 Pd implants were significantly

  12. A randomised controlled trial of intravenous zoledronic acid in malignant pleural disease: a proof of principle pilot study.

    Science.gov (United States)

    Clive, Amelia O; Hooper, Clare E; Edey, Anthony J; Morley, Anna J; Zahan-Evans, Natalie; Hall, David; Lyburn, Iain; White, Paul; Braybrooke, Jeremy P; Sequeiros, Iara; Lyen, Stephen M; Milton, Tim; Kahan, Brennan C; Maskell, Nick A

    2015-01-01

    Animal studies have shown Zoledronic Acid (ZA) may diminish pleural fluid accumulation and tumour bulk in malignant pleural disease (MPD). We performed a pilot study to evaluate its effects in humans. We undertook a single centre, double-blind, placebo-controlled trial in adults with MPD. Patients were randomised (1:1) to receive 2 doses of intravenous ZA or placebo, 3 weeks apart and were followed-up for 6 weeks. The co-primary outcomes were change in Visual Analogue Scale (VAS) score measured breathlessness during trial follow-up and change in the initial area under the curve (iAUC) on thoracic Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) from randomisation to week 5. Multiple secondary endpoints were also evaluated. Between January 2010 and May 2013, 30 patients were enrolled, 24 randomised and 4 withdrew after randomisation (1 withdrew consent; 3 had a clinical decline). At baseline, the ZA group were more breathless, had more advanced disease on radiology and worse quality of life than the placebo group. There was no significant difference between the groups with regards change in breathlessness (Adjusted mean difference (AMD) 4.16 (95%CI -4.7 to 13.0)) or change in DCE-MRI iAUC (AMD -15.4 (95%CI -58.1 to 27.3). Two of nine (22%) in the ZA arm had a >10% improvement by modified RECIST (vs 0/11 who received placebo). There was no significant difference in quality of life measured by the QLQ-C30 score (global QOL: AMD -4.1 (-13.0 to 4.9)), side effects or serious adverse event rates. This is the first human study to evaluate ZA in MPD. The study is limited by small numbers and imbalanced baseline characteristics. Although no convincing treatment effect was identified, potential benefits for specific subgroups of patients cannot be excluded. This study provides important information regarding the feasibility of future trials to evaluate the effects of ZA further. UK Clinical Research Network ID 8877 ISRCTN17030426 www.isrctn.com.

  13. Development of an Airborne Micropulse Water Vapor DIAL

    Science.gov (United States)

    Nehrir, A. R.; Ismail, S.

    2012-12-01

    Water vapor plays a key role in many atmospheric processes affecting both weather and climate. Airborne measurements of tropospheric water vapor profiles have been a longstanding observational need to not only the active remote sensing community but also to the meteorological, weather forecasting, and climate/radiation science communities. Microscale measurements of tropospheric water vapor are important for enhancing near term meteorological forecasting capabilities while mesoscale and synopticscale measurements can lead to an enhanced understanding of the complex coupled feedback mechanisms between water vapor, temperature, aerosols, and clouds. To realize tropospheric measurements of water vapor profiles over the microscale-synopticscale areas of meteorological interest, a compact and cost effective airborne micropulse differential absorption lidar (DIAL) is being investigated using newly emerging semiconductor based laser technology. Ground based micropulse DIAL (MPD) measurements of tropospheric water vapor and aerosol profiles up to 6 km and 15 km, respectively, have been previously demonstrated using an all semiconductor based laser transmitter. The DIAL transmitter utilizes a master oscillator power amplifier (MOPA) configuration where two semiconductor seed lasers are used to seed a single pass traveling wave tapered semiconductor optical amplifier (TSOA), producing up to 7μJ pulse energies over a 1 μs pulse duration at a 10 kHz pulse repetition frequency (PRF). Intercomparisons between the ground based instrument measurements and radiosonde profiles demonstrating the MPD performance under varying atmospheric conditions will be presented. Work is currently ongoing to expand upon the ground based MPD concept and to develop a compact and cost effective system capable of deployment on a mid-low altitude aircraft such as the NASA Langley B200 King Air. Initial lab experiments show that a two-three fold increase in the laser energy compared to the ground

  14. Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin

    International Nuclear Information System (INIS)

    Gonzalez, S.; Pathak, M.A.; Fitzpatrick, T.B.; Cuevas, J.; Villarrubia, V.G.

    1997-01-01

    Sunburn, immune suppression, photo-aging, and skin cancers result from uncontrolled overexposure of human skin to solar ultraviolet radiation (UVR). Preventive measures, including photo-protection, are helpful and can be achieved by topical sun-screening agents. Polypodium leucotomos (PL) has been used for the treatment of inflammatory diseases and has shown some in vitro and in vivo immunomodulating properties. Its beneficial photo-protective effects in the treatment of vitiligo and its antioxidant properties encouraged us to evaluate in vivo the potentially useful photo-protective property of natural extract of PL after topical application or oral ingestion. Twenty-one healthy volunteers [either untreated or treated with oral psoralens (8-MOP or 5-MOP)] were enrolled in this study and exposed to solar radiation for evaluation of the following clinical parameters: immediate pigment darkening (IPD), minimal erythema dose (MED), minimal melanogenic dose (MMD), and minimal phototoxic dose (MPD) before and after topical or oral administration of PL. Immunohistochemical assessment of CD1a-expressing epidermal cells were also performed. PL was found to be photo-protective after topical application as well as oral administration. PL increased UV dose required for IPD (P<0.01), MED (P<0.001) and MPD (P<0.001). After oral administration of PL, MED increased 2.,8±0.59 times and MPD increased 2.75±0.5 and 6.8±1.3 times depending upon the type of psoralen used. Immunohistochemical study revealed photo-protection of Langherhans cells by oral as well as topical PL. The observed photo-protective activities of oral or topical PL reveal a new avenue in examining the potentially useful field of systemic photo-protection and suggests that PL can be used as adjunct treatment and can make photochemotherapy and phototherapy possibly safe and effective when the control of cutaneous phototoxicity to PUVA or UVB is a limiting factor in such photo-therapies. (au)

  15. The 2.2 A resolution structure of the O(H) blood-group-specific lectin I from Ulex europaeus.

    Science.gov (United States)

    Audette, G F; Vandonselaar, M; Delbaere, L T

    2000-12-01

    The tertiary and quaternary structure of the lectin I from Ulex europaeus (UE-I) has been determined to 2.2 A resolution. UE-I is a dimeric metalloglycoprotein that binds the H-type 2 human blood group determinant [alpha-L-Fucalpha(1-->2)-beta-D-Galbeta(1-->4)-beta-D-Glc NAcalpha-]. Nine changes from the published amino acid sequence were necessary to account for the electron density. The quaternary structural organization of UE-I is that of the most commonly occurring legume lectin dimer. The tertiary structure of the monomeric subunits is similar to that in the conventional lectin subunit; however, some structural differences are noted. These differences include a four-stranded anti-parallel "S" sheet in UE-I versus the five-stranded S sheet in other lectin monomers. The Ala residue of the Ala-Asp cis-peptide bond present in the carbohydrate-binding site of the conventional lectin monomer is replaced with a Thr in the UE-I structure. Also, a novel disulfide bridge linking Cys115 and Cys150 is present. There are two metallic ions, one calcium and the other manganese, per subunit. N-linked oligosaccharides are at residues 23 and 111 of each subunit. One molecule of R-2-methyl-2, 4-pentanediol (R-MPD) is present in a shallow depression on the surface of each subunit. In order to examine the binding of the H-type 2 blood group determinant by UE-I, its beta-methyl glycoside (H-type 2-OMe) was docked into the binding site of R-MPD. The epitope previously identified for H-type 2-OMe by chemical mapping proved, with only minor adjustment of amino acid residues, to be complementary to the shallow cavity occupied by R-MPD in the structure. Several key interactions have been proposed between the H-type 2-OMe and UE-I. Copyright 2000 Academic Press.

  16. A Novel Statistical Approach for Ocean Colour Estimation of Inherent Optical Properties and Cyanobacteria Abundance in Optically Complex Waters

    Directory of Open Access Journals (Sweden)

    Monika Soja-Woźniak

    2017-04-01

    Full Text Available Eutrophication is an increasing problem in coastal waters of the Baltic Sea. Moreover, algal blooms, which occur every summer in the Gulf of Gdansk can deleteriously impact human health, the aquatic environment, and economically important fisheries, tourism, and recreation industries. Traditional laboratory-based techniques for water monitoring are expensive and time consuming, which usually results in limited numbers of observations and discontinuity in space and time. The use of hyperspectral radiometers for coastal water observation provides the potential for more detailed remote optical monitoring. A statistical approach to develop local models for the estimation of optically significant components from in situ measured hyperspectral remote sensing reflectance in case 2 waters is presented in this study. The models, which are based on empirical orthogonal function (EOF analysis and stepwise multilinear regression, allow for the estimation of parameters strongly correlated with phytoplankton (pigment concentration, absorption coefficient and coloured detrital matter abundance (absorption coefficient directly from reflectance spectra measured in situ. Chlorophyll a concentration, which is commonly used as a proxy for phytoplankton biomass, was retrieved with low error (median percent difference, MPD = 17%, root mean square error RMSE = 0.14 in log10 space and showed a high correlation with chlorophyll a measured in situ (R = 0.84. Furthermore, phycocyanin and phycoerythrin, both characteristic pigments for cyanobacteria species, were also retrieved reliably from reflectance with MPD = 23%, RMSE = 0.23, R2 = 0.77 and MPD = 24%, RMSE = 0.15, R2 = 0.74, respectively. The EOF technique proved to be accurate in the derivation of the absorption spectra of phytoplankton and coloured detrital matter (CDM, with R2 (λ above 0.83 and RMSE around 0.10. The approach was also applied to satellite multispectral remote sensing reflectance data, thus allowing

  17. A randomised controlled trial of intravenous zoledronic acid in malignant pleural disease: a proof of principle pilot study.

    Directory of Open Access Journals (Sweden)

    Amelia O Clive

    Full Text Available Animal studies have shown Zoledronic Acid (ZA may diminish pleural fluid accumulation and tumour bulk in malignant pleural disease (MPD. We performed a pilot study to evaluate its effects in humans.We undertook a single centre, double-blind, placebo-controlled trial in adults with MPD. Patients were randomised (1:1 to receive 2 doses of intravenous ZA or placebo, 3 weeks apart and were followed-up for 6 weeks. The co-primary outcomes were change in Visual Analogue Scale (VAS score measured breathlessness during trial follow-up and change in the initial area under the curve (iAUC on thoracic Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI from randomisation to week 5. Multiple secondary endpoints were also evaluated.Between January 2010 and May 2013, 30 patients were enrolled, 24 randomised and 4 withdrew after randomisation (1 withdrew consent; 3 had a clinical decline. At baseline, the ZA group were more breathless, had more advanced disease on radiology and worse quality of life than the placebo group. There was no significant difference between the groups with regards change in breathlessness (Adjusted mean difference (AMD 4.16 (95%CI -4.7 to 13.0 or change in DCE-MRI iAUC (AMD -15.4 (95%CI -58.1 to 27.3. Two of nine (22% in the ZA arm had a >10% improvement by modified RECIST (vs 0/11 who received placebo. There was no significant difference in quality of life measured by the QLQ-C30 score (global QOL: AMD -4.1 (-13.0 to 4.9, side effects or serious adverse event rates.This is the first human study to evaluate ZA in MPD. The study is limited by small numbers and imbalanced baseline characteristics. Although no convincing treatment effect was identified, potential benefits for specific subgroups of patients cannot be excluded. This study provides important information regarding the feasibility of future trials to evaluate the effects of ZA further.UK Clinical Research Network ID 8877 ISRCTN17030426 www.isrctn.com.

  18. Measurement of the Muon Atmospheric Production Depth with the Water Cherenkov Detectors of the Pierre Auger Observatory

    Energy Technology Data Exchange (ETDEWEB)

    Molina Bueno, Laura [Univ. of Granada (Spain)

    2015-09-01

    Ultra-high-energy cosmic rays (UHECR) are particles of uncertain origin and composition, with energies above 1 EeV (1018 eV or 0.16 J). The measured flux of UHECR is a steeply decreasing function of energy. The largest and most sensitive apparatus built to date to record and study cosmic ray Extensive Air Showers (EAS) is the Pierre Auger Observatory. The Pierre Auger Observatory has produced the largest and finest amount of data ever collected for UHECR. A broad physics program is being carried out covering all relevant topics of the field. Among them, one of the most interesting is the problem related to the estimation of the mass composition of cosmic rays in this energy range. Currently the best measurements of mass are those obtained by studying the longitudinal development of the electromagnetic part of the EAS with the Fluorescence Detector. However, the collected statistics is small, specially at energies above several tens of EeV. Although less precise, the volume of data gathered with the Surface Detector is nearly a factor ten larger than the fluorescence data. So new ways to study composition with data collected at the ground are under investigation. The subject of this thesis follows one of those new lines of research. Using preferentially the time information associated with the muons that reach the ground, we try to build observables related to the composition of the primaries that initiated the EAS. A simple phenomenological model relates the arrival times with the depths in the atmosphere where muons are produced. The experimental confirmation that the distributions of muon production depths (MPD) correlate with the mass of the primary particle has opened the way to a variety of studies, of which this thesis is a continuation, with the aim of enlarging and improving its range of applicability. We revisit the phenomenological model which is at the root of the analysis and discuss a new way to improve some aspects of the model. We carry

  19. The influence of type 1 and type 2 diabetes on periodontal disease progression: prospective results from the Study of Health in Pomerania (SHIP).

    Science.gov (United States)

    Demmer, Ryan T; Holtfreter, Birte; Desvarieux, Moïse; Jacobs, David R; Kerner, Wolfgang; Nauck, Matthias; Völzke, Henry; Kocher, Thomas

    2012-10-01

    To explore associations between diabetes etiology (type 1 diabetes mellitus [T1DM] vs. T2DM) and glycemic control in the prediction of 5-year periodontal status change. The Study of Health in Pomerania (SHIP) is a population-based stratified sample of German men and women. Healthy participants and those determined to have T2DM arose from the SHIP cohort, and T1DM participants were recruited from diabetes clinics in the catchment area that gave rise to SHIP. Dentate participants (n = 2,626; 53% women; 20-81 years of age) were included. Diabetes was determined via physician diagnosis and/or HbA(1c) ≥6.5% (uncontrolled diabetes >7.0%). Examiners blinded to diabetes status performed random half-mouth periodontal examinations, assessing probing depth (PD) and attachment loss (AL) (four sites/tooth) at baseline and follow-up. Participants were categorized into six groups as follows: 1) diabetes free (n = 2,280), 2) incident T2DM (n = 79), 3) controlled T2DM (n = 80), 4) uncontrolled T2DM (n = 72), 5) controlled T1DM (n = 43), and 6) uncontrolled T1DM (n = 72). In multivariable regressions, mean PD change (ΔMPD), mean AL change (ΔMAL), or incident tooth-loss values were regressed across the aforementioned diabetes categories. Mean (SD) ΔMPD and ΔMAL values among all participants were -0.08 ± 0.5 mm and 0.08 ± 1.03 mm, respectively, and 34% lost one or more teeth. Relative to diabetes-free participants, those with uncontrolled T2DM experienced greater ΔMPD ± SE (P T1DM or uncontrolled T2DM realized greater ΔMAL (P T1DM and T2DM were both associated with an increased risk of future tooth loss (P Diabetes control, but not etiology, was associated with future tooth loss and accelerated AL progression.

  20. An experimental investigation of cathode erosion in high current magnetoplasmadynamic arc discharges

    Science.gov (United States)

    Codron, Douglas A.

    Since the early to mid 1960's, laboratory studies have demonstrated the unique ability of magnetoplasmadynamic (MPD) thrusters to deliver an exceptionally high level of specific impulse and thrust at large power processing densities. These intrinsic advantages are why MPD thrusters have been identified as a prime candidate for future long duration space missions, including piloted Mars, Mars cargo, lunar cargo, and other missions beyond low Earth orbit (LEO). The large total impulse requirements inherent of the long duration space missions demand the thruster to operate for a significant fraction of the mission burn time while requiring the cathodes to operate at 50 to 10,000 kW for 2,000 to 10,000 hours. The high current levels lead to high operational temperatures and a corresponding steady depletion of the cathode material by evaporation. This mechanism has been identified as the life-limiting component of MPD thrusters. In this research, utilizing subscale geometries, time dependent cathode axial temperature profiles under varying current levels (20 to 60 A) and argon gas mass flow rates (450 to 640 sccm) for both pure and thoriated solid tungsten cathodes were measured by means of both optical pyrometry and charged-coupled (CCD) camera imaging. Thoriated tungsten cathode axial temperature profiles were compared against those of pure tungsten to demonstrate the large temperature reducing effect lowered work function imparts by encouraging increased thermionic electron emission from the cathode surface. Also, Langmuir probing was employed to measure the electron temperature, electron density, and plasma potential near the "active zone" (the surface area of the cathode responsible for approximately 70% of the emitted current) in order to characterize the plasma environment and verify future model predictions. The time changing surface microstructure and elemental composition of the thoriated tungsten cathodes were analyzed using a scanning electron microscope

  1. Instrumentation and controls of an ignited tokamak

    International Nuclear Information System (INIS)

    Becraft, W.R.; Golzy, J.; Houlberg, W.A.; Kukielka, C.A.; Onega, R.J.; Raju, G.V.S.; Stone, R.S.

    1980-10-01

    The instrumentation and controls (I and C) of an ignited plasma magnetically confined in a tokamak configuration needs increased emphasis in the following areas: (1) physics implications for control; (2) plasma shaping/position control; and (3) control to prevent disruptive instabilities. This document reports on the FY 1979 efforts in these and other areas. Also presented are discusssions in the areas of: (1) diagnostics suitable for the Engineering Test Facility (ETF); and (2) future research and development (R and D) needs. The appendices focus attention on some preliminary ideas about the measurement of the deuteron-triton (D-T) ratio in the plasma, synchrotron radiation, and divertor control. Finally, an appendix documenting the thermal consequences to the first wall of a MPD is presented

  2. The dosimetry of prostate brachytherapy-induced urethral strictures

    International Nuclear Information System (INIS)

    Merrick, Gregory S.; Butler, Wayne M.; Tollenaar, Bryan G.; Galbreath, Robert W.; Lief, Jonathan H.

    2002-01-01

    prescribed minimum prostate dose, mPD (p=0.031). The urethral dose 20 mm distal to the prostate apex was 57.6%±23.8% vs. 31.5%±13.9% of mPD for the stricture and control patients, respectively (p=0.011). In addition, the extent of the 75% mPD and 50% mPD levels beyond the prostatic apex was also significantly greater for stricture patients, 16.6±5.3 mm vs. 11.9±4.5 mm (p=0.010) and 19.0±3.2 mm vs. 16.0±3.4 mm (p=0.021), respectively. Dose to the prostatic urethra was not predictive of stricture, but the magnitude and extent of high-dose regions within the prostate were predictive of stricture. Twelve of the 13 patients who developed urethral strictures were successfully managed by dilatation/transurethral incision. To date, 1 of the 12 patients has required a second dilatation. The remaining patient developed an iatrogenic induced injury and was catheter-dependent for 6 months. Conclusions: After prostate brachytherapy, the actuarial 5-year incidence of urethral strictures is 5.3% with a median time to development of 26.6 months. All strictures involved the membranous urethra and occurred within the first 44 months after brachytherapy. In most cases, membranous urethral strictures are easily managed with dilatation/incision. Factors predicting for the development of a urethral stricture included the magnitude and extent of high-dose regions within the prostate, the mean membranous urethra dose and the dose 20 mm distal to the prostatic apex, the maximum extent along the membranous urethra of certain dose levels, and the duration of hormonal manipulation

  3. Plasma acceleration by magnetic nozzles and shock waves

    International Nuclear Information System (INIS)

    Hattori, Kunihiko; Murakami, Fumitake; Miyazaki, Hiroyuki; Imasaki, Atsushi; Yoshinuma, Mikirou; Ando, Akira; Inutake, Masaaki

    2001-01-01

    We have measured axial profiles of ion acoustic Mach number, M i , of a plasma flow blowing off from an MPD (magneto-plasma-dynamic) arc-jet in various magnetic configurations. It is found that the Mach number increases in a divergent nozzle up to 3, while it stays at about unity in a uniform magnetic channel. When a magnetic bump is added in the exit of the divergent magnetic nozzle, the Mach number suddenly decreases below unity, due to an occurrence of shock wave. The subsonic flow after the shock wave is re-accelerated to a supersonic flow through a magnetic Laval nozzle. This behavior is explained well by the one-dimensional isotropic flow model. The shock wave is discussed in relation to the Rankine-Hugoniot relation. (author)

  4. Multimegawatt dynamic NEP PMAD study

    International Nuclear Information System (INIS)

    Metcalf, K.J.

    1993-01-01

    The National Aeronautics and Space Administration Lewis Research Center (NASA LeRC) is developing a Fortran--based model of a complete nuclear electric propulsion (NEP) vehicle to be used for piloted or cargo missions to the Moon or Mars. The proposed vehicle will use either a Brayton or K-Rankine power conversion cycle, and either ion or magnetoplasmadynamic (MPD) thrusters. In support of this effort, Rocketdyne evaluated various power management and distribution (PMAD) approaches and selected a low-frequency design that is based on the direct use of the alternator voltage and frequency for power transmission. This approach was compared with dc and high-frequency ac designs, and selected on the basis of mass, efficiency, and qualitative assessments of power quality, reliability and development costs. This low-frequency architecture will be used as the reference in future NEP PMAD studies and for the subsequent Fortran model development

  5. A comparison of radiation dose to the neurovascular bundles in men with and without prostate brachytherapy-induced erectile dysfunction

    International Nuclear Information System (INIS)

    Merrick, Gregory S.; Butler, Wayne M.; Dorsey, Anthony T.; Lief, Jonathan H.; Donzella, Joseph G.

    2000-01-01

    Purpose: The etiology of erectile dysfunction after definitive local therapy for carcinoma of the prostate gland represents a multifactorial phenomenon including neurogenic compromise, venous insufficiency, local trauma, and psychogenic causes. It has been suggested that impotence after prostate brachytherapy is a consequence of excessive radiation dose to the neurovascular bundles (NVB). Herein we evaluate the potential relationship between radiation dose to the NVB and the development of erectile dysfunction following prostate brachytherapy. Methods and Materials: The radiation dose to the NVB was evaluated for 33 patients who developed erectile dysfunction (ED) following brachytherapy plus 21 additional patients who were potent before and subsequent to brachytherapy. Of the 54 patient study group, the median follow up was 37 months, and 25 patients were managed with 125 I as a monotherapeutic approach and 29 received 103 Pd as a boost following 45 Gy of external beam radiation therapy. Radiographic localization of the NVB was performed via a two-dimensional geometric model that placed 3-NVB calculation points on the left and right posterolateral side of each 5-mm CT slice. Parameters evaluated included dose-surface histograms, dose parameters via point doses on each slice, the magnitude of the dose in relationship to the distance from the base, and the relationship between NVB radiation dose in patients with and without ED, patient response to sildenafil and case sequence number. Results: In terms of percent prescribed minimum peripheral dose (% mPD), there was no significant difference in mean neurovascular bundle dose between potent and impotent patients, between the isotopes ( 125 I or 103 Pd), mono- or boost therapy, or side of the prostate for which the overall average was 217% ± 55% of mPD. There was also no significant dosimetric difference in terms of response to sildenafil based on a multivariate analysis which included % mPD and various dose

  6. Steady-state spheromak

    International Nuclear Information System (INIS)

    Jarboe, T.R.

    1982-01-01

    A major effort is being made in the national program to make the operation of axisymmetric, toroidal confinement systems steady state by the application of expensive rf current drive. Described here is a method by which such a confinement system, the spheromak, can be refluxed indefinitely through the application of dc power. As a step towards dc sustainment we have operated the present CTX source in the slow source mode with a longer power application time (approx. 0.1 ms) and successfully generated long-lived spheromaks. If the erosion of the electrodes can be controlled as well as it is with MPD arcs then dc operation should be very clean. If only a small fraction (approx. 10% for an experiment) of the poloidal flux of the spheromak connects to the source then the dc sustainment can be very efficient. The amount of connecting flux that is necessary for sustainment needs to be determined experimentally

  7. 2nd Symposium on applied nuclear physics and innovative technologies

    CERN Document Server

    2014-01-01

    Symposium on Applied Nuclear Physics and Innovative Technologies will be held for the second time at Collegium Maius, the oldest building of the Jagiellonian University in Cracow, the same building where Nicolaus Copernicus has studied astronomy. Symposium is organized in the framework of the MPD programme carried out by the Foundation for Polish science based on the European Structural Funds. The aim of this conference is to gather together young scientists and experts in the field of applied and fundamental nuclear as well as particle physics. Aiming at interplay of fundamental and applied science the conference will be devoted to the following topics: * Medical imaging and radiotherapy * New materials and technologies in radiation detection * Fission, fusion and spallation processes * High-performance signal processing and data analysis * Tests of foundations of physics and search for a new kind of sub-atomic matter

  8. NICA project at JINR: status and prospects

    International Nuclear Information System (INIS)

    Kekelidze, V.D.

    2017-01-01

    The project NICA (Nuclotron-based Ion Collider fAcility) is aimed to study hot and dense baryonic matter in heavy-ion collisions in the energy range up to 11.0 AGeV . The plan of NICA accelerator block development includes an upgrade of the existing superconducting (SC) synchrotron Nuclotron and construction of the new injection complex, SC Booster, and SC Collider with two interaction points (IP). The heavy-ion collision program will be performed with the fixed target experiment Baryonic Matter at Nuclotron (BM@N) at the beam extracted from the Nuclotron, and with Multi-Purpose Detector (MPD) at the first IP of NICA Collider. Investigation of nucleon spin structure and polarization phenomena is foreseen with the Spin Physics Detector (SPC) at the second IP of the Collider.

  9. Superconducting dipole magnet for the CBM experiment at FAIR

    Directory of Open Access Journals (Sweden)

    Kurilkin P.

    2017-01-01

    Full Text Available The scientific goal of the CBM (Compressed Baryonic Matter experiment at FAIR (Darmstadt is to explore the phase diagram of strongly interacting matter at highest baryon densities. The physics program of the CBM experiment is complimentary to the programs to be realized at MPD and BMN facilities at NICA and will start with beam derived by the SIS100 synchrotron. The 5.15 MJ superconducting dipole magnet will be used in the silicon tracking system of the CBM detector. The magnet will provide a magnetic field integral of 1 Tm which is required to obtain a momentum resolution of 1% for the track reconstruction. The results of the development of dipole magnet of the CBM experiment are presented.

  10. A Monte Carlo Study of Lambda Hyperon Polarization at BM@N

    Science.gov (United States)

    Suvarieva, D.; Gudima, K.; Zinchenko, A.

    2018-03-01

    Heavy strange objects (hyperons) can provide essential signatures of the excited and compressed baryonic matter. At NICA, it is planned to study hyperons both in the collider mode (MPD detector) and the fixed-target one (BM@N setup). Measurements of strange hyperon polarization can give additional information on the strong interaction mechanisms. In heavy-ion collisions, such measurements are even more valuable since the polarization is expected to be sensitive to characteristics of the QCD medium (vorticity, hydrodynamic helicity) and to QCD anomalous transport. In this analysis, the possibility to measure at BM@N the polarization of the lightest strange hyperon Λ is studied in Monte Carlo event samples of Au + Au collisions produced with the DCM-QGSM generator. It is shown that the detector will allow to measure polarization with a precision required to check the model predictions.

  11. Status of the NICA project at JINR

    Directory of Open Access Journals (Sweden)

    Kekelidze V.

    2016-01-01

    Full Text Available The project NICA (Nuclotron-based Ion Collider fAcility is aimed to study hot and dense baryonic matter in heavy ion collisions in the energy range up to √sNN = 11 GeV, and to study nucleon spin structure in polarized proton and deuteron collisions in the energy range up to √s = 27 GeV. The heavy ion program will be performed at the Nuclotron extracted beams with the BM@N (Baryonic Matter at Nuclotron set-up and with the MPD (MultiPurpose Detector at the NICA collider with the average luminosity of L = 1027 cm−2s−1 (for 197Au79+. The spin physics will be studied with the SPD (Spin Physics Detector at the NICA collider.

  12. Spectroscopic studies of a high Mach-number rotating plasma flow

    International Nuclear Information System (INIS)

    Ando, Akira; Ashino, Masashi; Sagi, Yukiko; Inutake, Masaaki; Hattori, Kunihiko; Yoshinuma, Mikirou; Imasaki, Atsushi; Tobari, Hiroyuki; Yagai, Tsuyoshi

    2001-01-01

    Characteristics of an axially-magnetized rotating plasma are investigated by spectroscopy in the HITOP device of Tohoku University. A He plasma flows our axially and rotates azimuthally near the muzzle region of the MPD arcjet. Flow and rotational velocities and temperature of He ions and atoms are measured by Doppler shift and broadening of the HeII (γ=468.58 nm) and HeI (γ=587.56 nm) lines. Rotational velocity increases with the increase of axially-applied magnetic field strength and discharge current. As discharge current increases and mass flow rate decreases, the plasma flow velocity increases and T i increases. Ion acoustic Mach number of the plasma flow also increases, but tends to saturate at near 1. Radial profile of space potential is calculated from the obtained rotational velocity. The potential profile in the core region is parabolic corresponding to the observed rigid-body rotation of the core plasma. (author)

  13. Spectroscopic studies of a high Mach-number rotating plasma flow

    Energy Technology Data Exchange (ETDEWEB)

    Ando, Akira; Ashino, Masashi; Sagi, Yukiko; Inutake, Masaaki; Hattori, Kunihiko; Yoshinuma, Mikirou; Imasaki, Atsushi; Tobari, Hiroyuki; Yagai, Tsuyoshi [Tohoku Univ., Dept. of Electrical Engineering, Sendai, Miyagi (Japan)

    2001-07-01

    Characteristics of an axially-magnetized rotating plasma are investigated by spectroscopy in the HITOP device of Tohoku University. A He plasma flows our axially and rotates azimuthally near the muzzle region of the MPD arcjet. Flow and rotational velocities and temperature of He ions and atoms are measured by Doppler shift and broadening of the HeII ({gamma}=468.58 nm) and HeI ({gamma}=587.56 nm) lines. Rotational velocity increases with the increase of axially-applied magnetic field strength and discharge current. As discharge current increases and mass flow rate decreases, the plasma flow velocity increases and T{sub i} increases. Ion acoustic Mach number of the plasma flow also increases, but tends to saturate at near 1. Radial profile of space potential is calculated from the obtained rotational velocity. The potential profile in the core region is parabolic corresponding to the observed rigid-body rotation of the core plasma. (author)

  14. Specific allogeneic unresponsiveness in the adult host: present-day experimental models

    International Nuclear Information System (INIS)

    Rapaport, F.T.; Bachvaroff, R.J.; Cronkite, E.; Chanana, A.; Sato, T.; Asari, H.; Waltzer, W.C.

    1982-01-01

    As part of a long-term intensive effort to apply the induction of adult allogensic unresponsiveness to the transplantation problem, two techniques to control the variability in the persistence of immunologically competent postthymic cells iin the treated host and/or the inoculum of autologous marrow returned to the host after irradiation are described. The first consisted of exposing the peripheral blood of prospective recipients to a 5-week course of extra-corporeal irradiation (ECIB), the other of exposing the stored autologous marrow scheduled to repopulate a given recipient to methyl-prednisolone (MPd) and DNase prior to renifusion into the recipient. Serial analysis of bone marrow cell samples at various intervals before and after treatment was undertaken. The significance of the disappearance of a particular population of nonnuclear cells from the samples, and the association of such disappearance with increased success in the induction of allogeneic unresponsiveness is discussed

  15. Research on Overflow Monitoring Mechanism Based on Downhole Microflow Detection

    Directory of Open Access Journals (Sweden)

    Liang Ge

    2014-01-01

    Full Text Available The flow rate variation of the drilling fluid and micro-overflow loss is difficult to analyze. The purpose to prevent the occurrence of kick, lost circulation, and other complex conditions is not easy to be achieved. Therefore, the microflow-induced annulus multiphase flow rate and annulus pressure field model were studied, and a downhole microflow measurement system has been developed. A differential pressure type flow measurement was used in the system, and real-time downhole information was obtained to achieve deep, narrow windows and other safety-density complex formation security. This paper introduced a new bottom-hole flow meter which can measure the annular flux while drilling and monitor overflow and circulation loss. The accuracy and reliability of the MPD (managed pressure drilling system can be improved obviously by applying the device; as a result, the safety of drilling is enhanced and the cost is reduced.

  16. Multiphoton ionization/dissociation of osmium tetroxide

    International Nuclear Information System (INIS)

    Ding, D.; Puretzky, A.A.; Compton, R.N.

    1993-01-01

    The mechanisms leading to laser multiphoton ionization and dissociation (MPI/MPD) of osmium tetroxide (OsO 4 ) have been investigated from measurements of the kinetic energies of product ions (Os + , Os 2+ , OsO + , O 2 + , O + ) and photoelectrons as a function of the laser wavelength. Neutral channels, intermediate to the dominant Os + ionization channel, such as OsO 4 →OsO 4-n +nO are examined using resonance-enhanced multiphoton ionization (REMPI) of the fast O atoms. Equipartition of the available photon energy among the fragments is observed. The wavelength dependence of the Os + ion signal suggests that one or more of the steps leading to Os + ions involve molecular ions and/or excited neutral atoms. The observed preponderance of very slow ( 2+ is shown to result primarily from REMPI of Os +

  17. Many-body processes in atomic and molecular physics. Progress report, September 1, 1982-August 31, 1983

    International Nuclear Information System (INIS)

    Chu, S.I.

    1983-04-01

    Progress is reported in the following areas: (1) development of a powerful semiclassical many-mode Floquet theory for nonperturbative treatment of the multiphoton dynamics of a quantum system interacting with several monochromatic radiation fields, (2) development of analytical quasi-level models for line shape analysis of intense field molecular multiphoton absorption spectra, (3) completion of a high-precision rotatonal predissociation lifetime determination of Ar-H 2 and Ar-HD van der Waals (vdW) molecules, using the complex-coordinate coupled-channel (CCCC) formalisms, and (4) development of the complex quasi-vibrational energy (QVE) and the inhomogeneous differential equation (IDE) approaches for calculating multiphoton dissociation (MPD) rates from highly excited vibrational states of diatomic molecules

  18. Asymmetric Reprogramming Capacity of Parental Pronuclei in Mouse Zygotes

    Directory of Open Access Journals (Sweden)

    Wenqiang Liu

    2014-03-01

    Full Text Available It has been demonstrated that reprogramming factors are sequestered in the pronuclei of zygotes after fertilization, because zygotes enucleated at the M phase instead of interphase of the first mitosis can support the development of cloned embryos. However, the contribution of the parental pronucleus derived from either the sperm or the oocyte in reprogramming remains elusive. Here, we demonstrate that the parental pronuclei have asymmetric reprogramming capacities and that the reprogramming factors reside predominantly in the male pronucleus. As a result, only female pronucleus-depleted (FPD mouse zygotes can reprogram somatic cells to a pluripotent state and support the full-term development of cloned embryos; male pronucleus-depleted (MPD zygotes fail to support somatic cell reprogramming. We further demonstrate that fusion of an additional male pronucleus into a zygote greatly enhances reprogramming efficiency. Our data provide a clue to further identify critical reprogramming factors in the male pronucleus.

  19. Modelado matemático del crecimiento de Microcystis aeruginosa en condiciones de laboratorio bajo diferentes temperaturas

    OpenAIRE

    Crettaz Minaglia, Melina Celeste; Rosso, Lorena; Aranda, Oswaldo; Sedan, Daniela; Juárez, Iván; Ventosi, Ezequiel; Andrinolo, Darío; Giannuzzi, Leda

    2017-01-01

    Los efectos de la temperatura (26°C, 28°C, 30°C y 35°C) sobre el crecimiento de Microcystis aeruginosa fueron estudiados en condiciones de laboratorio. Los parámetros cinéticos: velocidad específica de crecimiento (µ), duración de la fase de latencia (LPD) y máxima densidad poblacional (MPD) fueron determinados a través de la ecuación de Gompertz utilizando los recuentos celulares (cél.mL-1). Los valores de LPD disminuyeron 10,9 veces y los de µ aumentaron 4,8 veces al aumentar la temperatura...

  20. CRC handbook of radiobiology

    International Nuclear Information System (INIS)

    Prasad, K.N.

    1984-01-01

    The author presents Development of Radiobiology. A Review. Basic Cell Biology. Physics of Radiation Biology. Cellular Radiation Damage. Modifications of Cellular Radiation Damage. Repair of Radiation Damage. Molecular Radiation Biology. Radiation Syndromes and their Modifications. Radiation Damage of Skin and Mucous Membrane. Radiation Damage of Nervous Tissue. Radiation Damage of Reproductive Organs. Radiation Damage of Other Organ Systems. Radiation Immunology. Background, Medical and Commercial Sources. Radiation Injuries to Human Fetuses. Radiation-Induced Genetic Damage. Radiation Carcinogenesis: Tissue Culture Model. Radiation Carcinogenesis: Animal Model. Radiation Carcinogenesis: Human Model. Radiation Carcinogenesis: Secondary Neoplasms. After Therapy of Tumors. Other Late Effects: Aging, Cataract, Aplastic Anemia. Maximum Permissible Dose (MPD). Radiation Response of Human Tumor. Radioisotopes in Biology and Medicine

  1. The Relation Between Structure-Performance of Thin Film Composite Membranes and the Tools Used for Their Fabrication Method

    DEFF Research Database (Denmark)

    Briceno, Kelly; Javakhishvili, Irakli; Guo, Haofei

    For more than 30 years polyimides (PA) have been one of the main polymers for the fabrication of thin film composite membranes. Several researchers have assessed the main fabrication variables that influence the final structure of the polyamide layers including monomer concentration, solvents....... A polymeric support is initially brought in contact with the aqueous phase containing m-phenylene diamine (MPD) monomer and then with the organic phase containing the trimesoly chloride (TMC) monomer in order to promote PA formation through interfacial polymerization. The critical step occurs immediately......, or for that matter the absence of any tool using only water evaporation. In this work different methods of avoiding drop formation during the membrane preparation are tested to evaluate how the preparation methods influence the membrane structure and the final membrane properties. Understanding the membrane...

  2. Microstructural evolution during transient liquid phase bonding of Inconel 617 using Ni-Si-B filler metal

    International Nuclear Information System (INIS)

    Jalilian, F.; Jahazi, M.; Drew, R.A.L.

    2006-01-01

    The influence of process parameters on microstructural characteristics of transient liquid phase (TLP) bonded Inconel 617 alloy was investigated. Experiments were carried out at 1065 deg. C using nickel based filler metal (Ni-4.5% Si-3% B) with B as the melting point depressant (MPD) element. Two different thickness of interlayer and various holding times were employed. The influence of these processing parameters on the characteristics of the joint area particularly size, morphology and composition of precipitates was investigated. The presence of MoB, Mo 2 B, M 23 C 6 , TiC, M 23 (B, C) 6 and Ni 3 B precipitates in the diffusion layer and Ni 3 B, Ni 3 Si and Ni 5 Si 2 precipitates in the interlayer at the interface between the base metal and interlayer were demonstrated using electron back scattered diffraction (EBSD), energy dispersive spectrometry (EDS) and TEM

  3. Emission mechanism in high current hollow cathode arcs

    International Nuclear Information System (INIS)

    Krishnan, M.

    1976-01-01

    Large (2 cm-diameter) hollow cathodes have been operated in a magnetoplasmadynamic (MPD) arc over wide ranges of current (0.25 to 17 kA) and mass flow (10 -3 to 8 g/sec), with orifice current densities and mass fluxes encompassing those encountered in low current steady-state hollow cathode arcs. Detailed cathode interior measurements of current and potential distributions show that maximum current penetration into the cathode is about one diameter axially upstream from the tip, with peak inner surface current attachment up to one cathode diameter upstream of the tip. The spontaneous attachment of peak current upstream of the cathode tip is suggested as a criterion for characteristic hollow cathode operation. This empirical criterion is verified by experiment

  4. An analytical optimization method for electric propulsion orbit transfer vehicles

    International Nuclear Information System (INIS)

    Oleson, S.R.

    1993-01-01

    Due to electric propulsion's inherent propellant mass savings over chemical propulsion, electric propulsion orbit transfer vehicles (EPOTVs) are a highly efficient mode of orbit transfer. When selecting an electric propulsion device (ion, MPD, or arcjet) and propellant for a particular mission, it is preferable to use quick, analytical system optimization methods instead of time intensive numerical integration methods. It is also of interest to determine each thruster's optimal operating characteristics for a specific mission. Analytical expressions are derived which determine the optimal specific impulse (Isp) for each type of electric thruster to maximize payload fraction for a desired thrusting time. These expressions take into account the variation of thruster efficiency with specific impulse. Verification of the method is made with representative electric propulsion values on a LEO-to-GEO mission. Application of the method to specific missions is discussed

  5. Use of High-Power Brayton Nuclear Electric Propulsion (NEP) for a 2033 Mars Round-Trip Mission

    International Nuclear Information System (INIS)

    McGuire, Melissa L.; Martini, Michael C.; Packard, Thomas W.; Weglian, John E.; Gilland, James H.

    2006-01-01

    The Revolutionary Aerospace Systems Concepts (RASC) team, led by the NASA Langley Research Center, is tasked with exploring revolutionary new approaches to enabling NASA to achieve its strategic goals and objectives in future missions. This paper provides the details from the 2004-2005 RASC study of a point-design that uses a high-power nuclear electric propulsion (NEP) based space transportation architecture to support a manned mission to Mars. The study assumes a high-temperature liquid-metal cooled fission reactor with a Brayton power conversion system to generate the electrical power required by magnetoplasmadynamic (MPD) thrusters. The architecture includes a cargo vehicle with an NEP system providing 5 MW of electrical power and a crewed vehicle with an NEP system with two reactors providing a combined total of 10 MW of electrical power. Both vehicles use a low-thrust, high-efficiency (5000 sec specific impulse) MPD system to conduct a spiral-out of the Earth gravity well, a low-thrust heliocentric trajectory, and a spiral-in at Mars with arrival late in 2033. The cargo vehicle carries two moon landers to Mars and arrives shortly before the crewed vehicle. The crewed vehicle and cargo vehicle rendezvous in Mars orbit and, over the course of the 60-day stay, the crew conducts nine-day excursions to Phobos and Deimos with the landers. The crewed vehicle then spirals out of Martian orbit and returns via a low-thrust trajectory to conduct an Earth flyby. The crew separates from the vehicle prior to Earth flyby and aerobrakes for a direct-entry landing

  6. Effect of partial replacement of alfalfa hay with Moringa species leaves on milk yield and composition of Najdi ewes.

    Science.gov (United States)

    Babiker, Elfadıl E; Al Juhaimi, Fahad; Ghafoor, Kashif; Mohamed, H E; Abdoun, Khalid A

    2016-10-01

    The present study was carried out to investigate changes in milk yield and composition of Najdi ewes fed 25 % Moringa oleifera (MOD) or Moringa peregrina (MPD) leaf diets as a supplement to alfalfa hay diet (AHD). Thirty ewes (average 55 kg, 2 years old) were randomly sorted into three experimental groups with 10 animals each and were fed for a 6-week period with these diets (AHD, MOD, or MPD). Diets dry matter, crude protein, and crude fiber were comparable, while fat, nitrogen-free extract (NFE), neutral detergent fiber (NDF), acid detergent fiber (ADF), metabolizable energy (ME), total phenolic, and antioxidant activity varied (p ≤ 0.05) between the diets. Feeding ewes with MOD increased (p ≤ 0.05) the milk yield compared to those fed AHD while milk composition was similar (p ≤ 0.05) between treatments. The concentration of malondialdehyde (MDA) in the ewes' milk and serum was lower (p ≤ 0.05) for MOD, while the total antioxidant capacity, catalase activity, and vitamin C contents were increased (p ≤ 0.05). The serum cholesterol and glucose of the ewes were lower (p ≤ 0.05) for those fed MOD. Moringa diets increased (p ≤ 0.05) average daily weight gain of lambs compared to those fed alfalfa diets. The results obtained showed that the inclusion of Moringa, especially M. oleifera, in the diet of Najdi ewes can improve milk yield and quality.

  7. Patient-specific quality assurance for intracranial cases in robotic radiosurgery system.

    Science.gov (United States)

    Koksal, Canan; Akbas, Ugur; Donmez Kesen, Nazmiye; Okutan, Murat; Bilge, Hatice; Kemikler, Gonul

    2018-01-01

    The purpose of this study was to perform pretreatment patient-specific quality assurance (QA) for intracranial irradiation using CyberKnife with an ion chamber. Twenty-five intracranial plans created using the ray-tracing algorithm were used for this study. Computed tomography (CT) images of the water-equivalent RW3 slab phantom with PinPoint ionization chamber were acquired with 1-mm slice thickness and transferred to the MultiPlan treatment planning system (TPS). Four gold fiducial markers embedded into two different plates were used to tracking during the irradiation. Intracranial plans were transferred to CT images of the RW3 phantom. The isodose curves and sensitive volume of ion chamber were overlapped. Point dose measurements were performed three times and the mean point doses were calculated for each plan. The mean doses measured by the PinPoint ion chamber were compared with those of the calculated by MultiPlan TPS in the sensitive volume of PinPoint. The mean percentage difference (MPD) in point dose measurements was -2.44±1.97 for 25 plans. The maximum and minimum percentage differences between the measured and calculated absolute point doses were -7.14 and 0.23, respectively. The MPD was -1.70±1.90 for 12 plans using a fixed collimator and -3.11±1.86 for 13 plans using an IRIS cone. Point dose measurement is a reliable and functional method for pre-treatment patient-specific QA in intracranial CyberKnife plans. Point dose verification should be performed to correct any possible errors prior to patient treatment. It is recommended for use in patient-specific QA process in the CyberKnife plans.

  8. Human radiation experiments: Looking beyond the headlines

    International Nuclear Information System (INIS)

    Cohen, B.L.

    1994-01-01

    There has been a great deal of publicity recently about experiments supported by the U.S. Department of Energy and its predecessors, the Atomic Energy Commission (AEC) and the Energy Research and Development Administration, in which human subjects were exposed to radiation. Media stories give the impression that these experiments were done in secret, without informing the subjects, and that these subjects suffered horrible consequences. As a prelude to understanding the situation, it is useful to review the bases for judgement in deciding on this type of experiment. When it was first recognized that radiation can be harmful, national and international groups promulgated the concept of open-quotes maximum permissible doseclose quotes (MPD) on the basis that with a comfortable factor of safety (e.g., a factor of 10), there was no evidence of harm at that level. This had always been the principal method of providing safety, applied to everything from chemicals to bridges. In the 1940s, the MPD was 100 mrem per day, and it was assumed that there would be no harmful health impacts at that level. Current regulations require that experiments involving radiation exposure to human subjects be approved by a review board at the institution where they are carried out. National guidelines for these review boards require that whole-body doses to subjects be kept below 2 rem except in extraordinary circumstances. As an example of how these regulations are currently implemented, consider positron emission tomography (PET), a very active medical research topic for the past few years. In one major medical center, this involves exposing about 300 subjects per year, normally recruited through newspaper advertisements, with an average dose of about 400 mrem to each. There are about 50 comparable medical centers throughout the United States

  9. Mutations in the NHEJ component XRCC4 cause primordial dwarfism.

    Science.gov (United States)

    Murray, Jennie E; van der Burg, Mirjam; IJspeert, Hanna; Carroll, Paula; Wu, Qian; Ochi, Takashi; Leitch, Andrea; Miller, Edward S; Kysela, Boris; Jawad, Alireza; Bottani, Armand; Brancati, Francesco; Cappa, Marco; Cormier-Daire, Valerie; Deshpande, Charu; Faqeih, Eissa A; Graham, Gail E; Ranza, Emmanuelle; Blundell, Tom L; Jackson, Andrew P; Stewart, Grant S; Bicknell, Louise S

    2015-03-05

    Non-homologous end joining (NHEJ) is a key cellular process ensuring genome integrity. Mutations in several components of the NHEJ pathway have been identified, often associated with severe combined immunodeficiency (SCID), consistent with the requirement for NHEJ during V(D)J recombination to ensure diversity of the adaptive immune system. In contrast, we have recently found that biallelic mutations in LIG4 are a common cause of microcephalic primordial dwarfism (MPD), a phenotype characterized by prenatal-onset extreme global growth failure. Here we provide definitive molecular genetic evidence supported by biochemical, cellular, and immunological data for mutations in XRCC4, encoding the obligate binding partner of LIG4, causing MPD. We report the identification of biallelic mutations in XRCC4 in five families. Biochemical and cellular studies demonstrate that these alterations substantially decrease XRCC4 protein levels leading to reduced cellular ligase IV activity. Consequently, NHEJ-dependent repair of ionizing-radiation-induced DNA double-strand breaks is compromised in XRCC4 cells. Similarly, immunoglobulin junctional diversification is impaired in cells. However, immunoglobulin levels are normal, and individuals lack overt signs of immunodeficiency. Additionally, in contrast to individuals with LIG4 mutations, pancytopenia leading to bone marrow failure has not been observed. Hence, alterations that alter different NHEJ proteins give rise to a phenotypic spectrum, from SCID to extreme growth failure, with deficiencies in certain key components of this repair pathway predominantly exhibiting growth deficits, reflecting differential developmental requirements for NHEJ proteins to support growth and immune maturation. Copyright © 2015 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

  10. Physics and quality assurance for brachytherapy - Part II: Low dose rate and pulsed dose rate

    International Nuclear Information System (INIS)

    Williamson, Jeffrey F.

    1997-01-01

    Purpose: A number of recent developments have revitalized brachytherapy including remote afterloading, implant optimization, increasing use of 3D imaging, and advances in dose specification and basic dosimetry. However, the core physical principles underlying the classical methods of dose calculation and arrangement of multiple sources remain unchanged. The purpose of this course is to review these principles and their applications to low dose-rate interstitial and intracavitary brachytherapy. Emphasis will be placed upon the classical implant systems along with classical and modern methods of dose specification. The level of presentation is designed for radiation oncology residents and beginning clinical physicists. A. Basic Principles (1) Radium-substitute vs. low-energy sealed sources (2) Dose calculation principles (3) The mysteries of source strength specification revealed: mgRaEq, mCi and air-kerma strength B. Interstitial Brachytherapy (1) Target volume, implanted volume, dose specification in implants and implant optimization criteria (2) Classical implant systems: Manchester Quimby and Paris a) Application of the Manchester system to modern brachytherapy b) Comparison of classical systems (3) Permanent interstitial implants a) Photon energy and half life b) Dose specification and pre-operative planning (4) The alphabet soup of dose specification: MCD (mean central dose), minimum dose, MPD (matched peripheral dose), MPD' (minimum peripheral dose) and DVH (dose-volume histogram) quality indices C. Intracavitary Brachytherapy for Carcinoma of the Cervix (1) Basic principles a) Manchester System: historical foundation of U.S. practice patterns b) Principles of applicator design (2) Dose specification and treatment prescription a) mg-hrs, reference points, ICRU Report 38 reference volume -- Point A dose vs mg-hrs and IRAK (Integrated Reference Air Kerma) -- Tissue volume treated vs mg-hrs and IRAK b) Practical methods of treatment specification and prescription

  11. Comparative evolutionary diversity and phylogenetic structure across multiple forest dynamics plots: a mega-phylogeny approach

    Directory of Open Access Journals (Sweden)

    David Lee Erickson

    2014-11-01

    Full Text Available Forest dynamics plots, which now span longitudes, latitudes, and habitat types across the globe, offer unparalleled insights into the ecological and evolutionary processes that determine how species are assembled into communities. Understanding phylogenetic relationships among species in a community has become an important component of assessing assembly processes. However, the application of evolutionary information to questions in community ecology has been limited in large part by the lack of accurate estimates of phylogenetic relationships among individual species found within communities, and is particularly limiting in comparisons between communities. Therefore, streamlining and maximizing the information content of these community phylogenies is a priority. To test the viability and advantage of a multi-community phylogeny, we constructed a multi-plot mega-phylogeny of 1,347 species of trees across 15 forest dynamics plots in the ForestGEO network using DNA barcode sequence data (rbcL, matK and psbA-trnH and compared community phylogenies for each individual plot with respect to support for topology and branch lengths, which affect evolutionary inference of community processes. The levels of taxonomic differentiation across the phylogeny were examined by quantifying the frequency of resolved nodes throughout. In addition, three phylogenetic distance metrics that are commonly used to infer assembly processes were estimated for each plot (Phylogenetic Distance [PD], Mean Phylogenetic Distance [MPD], and Mean Nearest Taxon Distance [MNTD]. Lastly, we examine the partitioning of phylogenetic diversity among community plots through quantification of inter-community MPD and MNTD. Overall, evolutionary relationships were highly resolved across the DNA barcode-based mega-phylogeny, and phylogenetic resolution for each community plot was improved when estimated within the context of the mega-phylogeny. Likewise, when compared with phylogenies for

  12. Multiphoton dissociation and thermal unimolecular reactions induced by infrared lasers

    International Nuclear Information System (INIS)

    Dai, H.L.

    1981-04-01

    Multiphoton dissociation (MPD) of ethyl chloride was studied using a tunable 3.3 μm laser to excite CH stretches. The absorbed energy increases almost linearly with fluence, while for 10 μm excitation there is substantial saturation. Much higher dissociation yields were observed for 3.3 μm excitation than for 10 μm excitation, reflecting bottlenecking in the discrete region of 10 μm excitation. The resonant nature of the excitation allows the rate equations description for transitions in the quasicontinuum and continuum to be extended to the discrete levels. Absorption cross sections are estimated from ordinary ir spectra. A set of cross sections which is constant or slowly decreasing with increasing vibrational excitation gives good fits to both absorption and dissociation yield data. The rate equations model was also used to quantitatively calculate the pressure dependence of the MPD yield of SF 6 caused by vibrational self-quenching. Between 1000-3000 cm -1 of energy is removed from SF 6 excited to approx. > 60 kcal/mole by collision with a cold SF 6 molecule at gas kinetic rate. Calculation showed the fluence dependence of dissociation varies strongly with the gas pressure. Infrared multiphoton excitation was applied to study thermal unimolecular reactions. With SiF 4 as absorbing gas for the CO 2 laser pulse, transient high temperature pulses were generated in a gas mixture. IR fluorescence from the medium reflected the decay of the temperature. The activation energy and the preexponential factor of the reactant dissociation were obtained from a phenomenological model calculation. Results are presented in detail

  13. OCENA WŁAŚCIWOŚCI PRZECIWPOŚLIZGOWYCH NAWIERZCHNI DROGOWYCH PRZY WYKORZYSTANIU URZĄDZEŃ TWO, CTM I DFT

    Directory of Open Access Journals (Sweden)

    Marta WASILEWSKA

    2016-07-01

    Full Text Available Kompleksowa ocena właściwości przeciwpoślizgowych powinna być wykonywana w oparciu o ciągły pomiar współczynnika tarcia oraz parametrów dotyczących tekstury nawierzchni drogowych. W artykule przedstawiono ocenę właściwości przeciwpoślizgowych nawierzchni drogowych przeprowadzoną na podstawie pomiarów wykonanych zestawem pomiarowym TWO (Traction Watcher One oraz urządzeniami CTM (Circular Track Meter i DFT (Dynamic Friction Tester. Do badań wytypowano 11 odcinków testowych, których warstwy ścieralne były zróżnicowane pod względem technologii wykonania, okresu użytkowania i obciążenia ruchem samochodowym. Przy pomocy urządzenia CTM dokonano oceny makrotekstury (parametr MPD, a przy wykorzystaniu urządzenia DFT oceniano w sposób pośredni mikroteksturę powierzchni (współczynnik tarcia DFT20. Urządzenie TWO umożliwiło ciągły pomiar współczynnika tarcia z ustalonym poślizgiem 17,8% koła pomiarowego przy trzech prędkościach 30, 60, 90 km/h. W artykule ustalono zależności funkcyjne pomiędzy współczynnikiem tarcia µ z pomiarów TWO, a współczynnikiem DFT20 i parametrem MPD. Wykazano, że na wartość µ przy prędkości 30 km/h istotny wpływ ma jedynie mikrotekstura nawierzchni, a przy prędkości 60 i 90 km/h zarówno mikrotekstura i makrotekstura.

  14. Toxicological characteristics and primary radiobiological screening of Cystizid-M

    International Nuclear Information System (INIS)

    Minkova, M.; Pantev, T.; Georgieva, R.

    1987-01-01

    The toxic and radioprotective properties of the potential radioprotector of the mollecular combination Cystisid-M (cysteamine-adenosin-5'-monophosphate - CAM) were investigated. The experiments were carried out on male mice C 57 BI irradiated with 137 Cs source. The intraperitoneal administration of 1000 mg/kg b.w. and 500 mg/kg b.w., injected 15 min prior to the irradiation with 8,5 Gr (LD 90/30 ) was performed, and orally 3000 mg/kg b.w. and 1500 mg/kg b.w. was introduced into the stomach 45 min prior to the irradiation with 8,2 Gr (LD 83/30 ). The radioprotective effect of CAM was recorded according to: individual survival curves up to the 30th day; the biometrical coefficients 'ALPHA' (the individual survival expectancy in the population); and S 30 (the group survival expectancy). At the intraperitoneal administration of the protector the values of LD 50 = 1390 mg/kg b.w. and MPD (maximum permissible dose) = 1200 mg/kg b.w. were found. At the oral administration these doses were LD 50/3 = 4630 mg/kg b.w. and MPD = 3500 mg/kg b.w. It was established that CAM injected intraperitoneally in a dose of 1000 mg/kg b.w. ensured 75% survival of the protected mice against 10% of the control ones, increased the mean survival of the deceased and reduced the percentage of the animals died during the height of the bone marrow syndrome. The twofold lower dose exetted a considerably slighter effect. At oral administration the protector did not significantly modify the survival of the animals. The data obtained revealed the perspectiveness of the tested protective agent radiobiological investigations are required

  15. Política e cinema na era da Boa Vizinhança (1933-1945 * Policy and cinema at the age of the Good Neighbor (1933-1945

    Directory of Open Access Journals (Sweden)

    ISAIAS ALBERTIN DE MORAES

    2015-03-01

    Full Text Available Resumo: O presente artigo apresenta uma análise histórica da Política Externa de Boa Vizinhança para América Latina, particularmente no Brasil, e de sua principal instituição o Office of the coordinator of Inter-American Affairs (OCIAA, destacando sua divisão de cinema, a Motion Picture Division (MPD. Essas instituições são analisadas pelo enfoque teórico dos construtivistas modernistas-linguistas. Assim, o texto busca destacar a importância da construção de uma infraestrutura física, discursiva e humana com habilidade para selecionar, organizar, regular e redistribuir os discursos enunciados pela Política Externa de Boa Vizinhança no setor da indústria cinematográfica.Palavras-chave: Política Externa de Boa Vizinhança; Office of the coordinator of Inter-American Affairs; Motion Picture Division.  Abstract: This paper presents a historical analysis of the Good Neighbor Policy for Latin America, particularly in Brazil, and its main institution the Office of the coordinator of Inter-American Affairs (OCIAA, focusing on its film department, the Motion Picture Division (MPD. These institutions are analyzed by the theoretical approach of modernist linguists constructivists. So this text sought to highlight the importance of building a physical infrastructure, discursive and human with the ability to select, organize, regulate and redistribute the speeches set out by the Good Neighbor Policy in the film industry sector.Keywords: Good Neighbor Policy; Office of the coordinator of Inter-American Affairs; Motion Picture Division.

  16. Radiographic Shape of Foot With Second Metatarsophalangeal Joint Dislocation Associated With Hallux Valgus.

    Science.gov (United States)

    Kokubo, Tetsuro; Hashimoto, Takeshi; Suda, Yasunori; Waseda, Akeo; Ikezawa, Hiroko

    2017-12-01

    Second metatarsophalangeal (MTP) joint dislocation is associated with hallux valgus, and the treatment of complete dislocation can be difficult. The purpose of this study was to radiographically clarify the characteristic foot shape in the presence of second MTP joint dislocation. Weight-bearing foot radiographs of the 268 patients (358 feet) with hallux valgus were examined. They were divided into 2 groups: those with second MTP joint dislocation (study group = 179 feet) and those without dislocation (control group = 179 feet). Parameters measured included the hallux valgus angle (HVA), first-second intermetatarsal angle (IMA), second MTP joint angle, hallux interphalangeal angle (IPA), second metatarsal protrusion distance (MPD), metatarsus adductus angle (MAA), and the second metatarsal declination angle (2MDA). Furthermore, the dislocation group was divided into 3 subgroups according to second toe deviation direction: group M (medial type), group N (neutral type), and group L (lateral type). The IPA and the 2MDA were significantly greater in the study group than in the control group. By multiple comparison analysis, the IMA was greatest in group M and smallest in group L. The IPA was smaller and 2MDA greater in group N than in group L. The HVA and MAA in group L were greatest, and MPD in group L was smallest. The patients with second MTP joint dislocation associated with hallux valgus had greater hallux interphalangeal joint varus and a second metatarsal more inclined than with hallux valgus alone. The second toe deviated in a different direction according to the foot shape. Level III, retrospective comparative study.

  17. Update of ZTH physics and design issues and physics goals of ZTH and role in the Fusion Program

    International Nuclear Information System (INIS)

    DiMarco, J.N.

    1990-01-01

    The ZTH construction program is scheduled for completion in December of 1992. Some design features are still amenable to changes directed by new physics or computational information. Numerical results for the ZTH tapered poloidal field gap show that a relatively simple linear taper results in substantial reduction in field error. This design is simpler to manufacture compared with the compound curve predicted by analytical calculations. Also, ongoing analysis of ZT-40M data indicates that the fluctuation levels of magnetic fields and x-rays at high θ (1.7), can be reduced to the fluctuation levels at ''standard'' operational θ (1.4) by changing the winding configuration of the toroidal field (TF) coils. The effect is thought to depend on the shell-like action of the TF coils when they consist of many turns in parallel. Magnetic-field effects, such as field errors, at the unshielded toroidal-field butt-joint gap in the shell can be reduced by this effective external shell. Design implications for installing a second low-current TF coil on ZTH are presented. ZTH has the capability of operating at 4 MA with the addition of power supplies. The projected parameters of ZTH are discussed in the context of various conceptual design. The sensitivity of the conceptual design to the physics results from machines like RFX and ZTH is reviewed. It is shown that the 4 MA ZTH physics results will make a significant advance for the RFP program toward the programmatic RFP fusion goals. Finally, the influence of RFP and tokamak physics on the conceptual design of high mass-power-density (MPD) fusion reactors is investigated through the TITAN and ARIES studies. The confinement characteristics required of these conceptual designs are compared; physics issues are identified that are required to bring the MPD and fusion-power-core of the tokamak designs into coincidence with the RFP designs

  18. Novel prostate brachytherapy technique: Improved dosimetric and clinical outcome

    International Nuclear Information System (INIS)

    Nobes, Jenny P.; Khaksar, Sara J.; Hawkins, Maria A.; Cunningham, Melanie J.; Langley, Stephen E.M.; Laing, Robert W.

    2008-01-01

    Purpose: Erectile dysfunction following prostate brachytherapy is reported to be related to dose received by the penile bulb. To minimise this, whilst preserving prostate dosimetry, we have developed a technique for I-125 seed brachytherapy using both stranded seeds and loose seeds delivered with a Mick applicator, and implanted via the sagittal plane on trans-rectal ultrasound. Materials and methods: Post-implant dosimetry and potency rates were compared in 120 potent patients. In Group 1, 60 patients were treated using a conventional technique of seeds implanted in a modified-uniform distribution. From January 2005, a novel technique was developed using stranded seeds peripherally and centrally distributed loose seeds implanted via a Mick applicator (Group 2). The latter technique allows greater flexibility when implanting the seeds at the apex. Each patient was prescribed a minimum peripheral dose of 145 Gy. No patients received external beam radiotherapy or hormone treatment. There was no significant difference in age or pre-implant potency score (mean IIEF-5 score 22.4 vs. 22.6, p = 0.074) between the two groups. Results: The new technique delivers lower penile bulb doses (D 25 as %mPD - Group 1: 61.2 ± 35.7, Group 2: 29.7 ± 16.0, p 50 as %mPD - Group 1: 45.8 ± 26.9, Group 2: 21.4 ± 11.7, p 90 - Group 1: 147 Gy ± 21.1, Group 2: 155 Gy ± 16.7, p = 0.03). At 2 years, the potency rate was also improved: Group 1: 61.7%; Group 2: 83.3% (p = 0.008). Conclusions: In this study, the novel brachytherapy technique using both peripheral stranded seeds and central loose seeds delivered via a Mick applicator results in a lower penile bulb dose whilst improving prostate dosimetry, and may achieve higher potency rates

  19. Fiber Optic Sensors For Detection of Toxic and Biological Threats

    Directory of Open Access Journals (Sweden)

    Jianming Yuan

    2007-12-01

    Full Text Available Protection of public and military personnel from chemical and biological warfareagents is an urgent and growing national security need. Along with this idea, we havedeveloped a novel class of fiber optic chemical sensors, for detection of toxic and biologicalmaterials. The design of these fiber optic sensors is based on a cladding modificationapproach. The original passive cladding of the fiber, in a small section, was removed and thefiber core was coated with a chemical sensitive material. Any change in the opticalproperties of the modified cladding material, due to the presence of a specific chemicalvapor, changes the transmission properties of the fiber and result in modal powerredistribution in multimode fibers. Both total intensity and modal power distribution (MPDmeasurements were used to detect the output power change through the sensing fibers. TheMPD technique measures the power changes in the far field pattern, i.e. spatial intensitymodulation in two dimensions. Conducting polymers, such as polyaniline and polypyrrole,have been reported to undergo a reversible change in conductivity upon exposure tochemical vapors. It is found that the conductivity change is accompanied by optical propertychange in the material. Therefore, polyaniline and polypyrrole were selected as the modifiedcladding material for the detection of hydrochloride (HCl, ammonia (NH3, hydrazine(H4N2, and dimethyl-methl-phosphonate (DMMP {a nerve agent, sarin stimulant},respectively. Several sensors were prepared and successfully tested. The results showeddramatic improvement in the sensor sensitivity, when the MPD method was applied. In thispaper, an overview on the developed class of fiber optic sensors is presented and supportedwith successful achieved results.

  20. Progressive loss of pancreatic function in chronic pancreatitis is delayed by main pancreatic duct decompression. A longitudinal prospective analysis of the modified puestow procedure.

    Science.gov (United States)

    Nealon, W H; Thompson, J C

    1993-05-01

    This study evaluated the effect of operative drainage of the main pancreatic duct (MPD) on functional derangements associated with chronic pancreatitis (CP). The author previously reported delayed functional impairment in an evaluation of the impact of operative drainage in patients with CP. The author now reports on a prospective study of 143 patients with this diagnosis. Each patient underwent 1) ERCP, 2) the Bentiromide PABA, 3) 72-hour fecal fat test, 4) oral glucose tolerance test (OGTT) and 5) fat meal (LIPOMUL)--stimulated pancreatic polypeptide release (PP). All patients were stratified as mild/moderate (M/M) or severe CP on the basis of a 5-point system that was developed by the author. Patients were studied at 16-month intervals. All 143 patients underwent initial and follow-up evaluations in a mean follow-up of 47.3 months; 83 of 143 patients had M/M grade at initial evaluation. Eighty-seven patients underwent (MPD) decompression to relieve abdominal pain. In a separate prospective 17 patients with a diagnosis of CP, a grade of M/M and non-disabling abdominal pain were randomized to operative or non-operative treatment; 9 of these randomized patients were operated upon and 8 were not. No patient improved their grade during follow-up; 47 of 83 M/M patients had operative drainage and 36 did not. This grade was preserved in 41 of 47 (87%) operated patients but in only 8 of the 36 non-operated patients (22%). In the randomized trial, seven of nine operated patients retained their functional status in follow-up, whereas only two of eight patients (25%) randomized to non-operation preserved their functional grade. These data in this large study as well as among a previous randomized sample, support a policy of early operative drainage before the development of irreversible functional impairment in patients with chronic pancreatitis and associated dilation of the main pancreatic duct.

  1. Physics and quality assurance for brachytherapy - Part II: Low dose rate and pulsed dose rate

    International Nuclear Information System (INIS)

    Williamson, Jeffrey F.

    1996-01-01

    Purpose: A number of recent developments have revitalized brachytherapy including remote afterloading, implant optimization, increasing use of 3D imaging, and advances in dose specification and basic dosimetry. However, the core physical principles underlying the classical methods of dose calculation and arrangement of multiple sources remain unchanged. The purpose of this course is to review these principles and their applications to low dose-rate interstitial and intracavitary brachytherapy. Emphasis will be placed upon the classical implant systems along with classical and modern methods of dose specification. The level of presentation is designed for radiation oncology residents and beginning clinical physicists. A. Basic Principles (1) Radium-substitute vs. low-energy sealed sources (2) Dose calculation principles (3) The mysteries of source strength specification revealed: mgRaEq, mCi and air-kerma strength B. Interstitial Brachytherapy (1) Target volume, implanted volume, dose specification in implants and implant optimization criteria (2) Classical implant systems: Manchester Quimby and Paris a) Application of the Manchester system to modern brachytherapy b) Comparison of classical systems (3) Permanent interstitial implants a) Photon energy and half life b) Dose specification and pre-operative planning (4) The alphabet soup of dose specification: MCD (mean central dose), minimum dose, MPD (matched peripheral dose), MPD' (minimum peripheral dose) and DVH (dose-volume histogram) quality indices C. Intracavitary Brachytherapy for Carcinoma of the Cervix (1) Basic principles a) Manchester System: historical foundation of U.S. practice patterns b) Principles of applicator design (2) Dose specification and treatment prescription a) mg-hrs, reference points, ICRU Report 38 reference volume --Point A dose vs mg-hrs and IRAK (Integrated Reference Air Kerma) --Tissue volume treated vs mg-hrs and IRAK b) Practical methods of treatment specification and prescription

  2. The effect of anterior proton beams in the setting of a prostate-rectum spacer

    Energy Technology Data Exchange (ETDEWEB)

    Christodouleas, John P., E-mail: christojo@uphs.upenn.edu [Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA (United States); Tang, Shikui [Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA (United States); Susil, Robert C.; McNutt, Todd R.; Song, Danny Y. [Department of Radiation Oncology and Radiation Molecular Sciences, Johns Hopkins Hospital, Baltimore, MD (United States); Bekelman, Justin; Deville, Curtiland; Vapiwala, Neha [Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA (United States); DeWeese, Theodore L. [Department of Radiation Oncology and Radiation Molecular Sciences, Johns Hopkins Hospital, Baltimore, MD (United States); Lu, Hsiao-Ming [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States); Both, Stefan [Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA (United States)

    2013-10-01

    Studies suggest that anterior beams with in vivo range verification would improve rectal dosimetry in proton therapy for prostate cancer. We investigated whether prostate-rectum spacers would enhance or diminish the benefits of anterior proton beams in these treatments. Twenty milliliters of hydrogel was injected between the prostate and rectum of a cadaver using a transperineal approach. Computed tomography (CT) and magnetic resonance (MR) images were used to generate 7 uniform scanning (US) and 7 single-field uniform dose pencil-beam scanning (PBS) plans with different beam arrangements. Pearson correlations were calculated between rectal, bladder, and femoral head dosimetric outcomes and beam arrangement anterior scores, which characterize the degree to which dose is delivered anteriorly. The overall quality of each plan was compared using a virtual dose-escalation study. For US plans, rectal mean dose was inversely correlated with anterior score, but for PBS plans there was no association between rectal mean dose and anterior score. For both US and PBS plans, full bladder and empty bladder mean doses were correlated with anterior scores. For both US and PBS plans, femoral head mean doses were inversely correlated with anterior score. For US plans and a full bladder, 4 beam arrangements that included an anterior beam tied for the highest maximum prescription dose (MPD). For US plans and an empty bladder, the arrangement with 1 anterior and 2 anterior oblique beams achieved the highest MPD in the virtual dose-escalation study. The dose-escalation study did not differentiate beam arrangements for PBS. All arrangements in the dose-escalation study were limited by bladder constraints except for the arrangement with 2 posterior oblique beams. The benefits of anterior proton beams in the setting of prostate-rectum spacers appear to be proton modality dependent and may not extend to PBS.

  3. The effect of anterior proton beams in the setting of a prostate-rectum spacer

    Science.gov (United States)

    Christodouleas, John P.; Tang, Shikui; Susil, Robert C.; McNutt, Todd R.; Song, Danny Y.; Bekelman, Justin; Deville, Curtiland; Vapiwala, Neha; DeWeese, Theodore L.; Lu, Hsiao-Ming; Both, Stefan

    2014-01-01

    Studies suggest that anterior beams with in vivo range verification would improve rectal dosimetry in proton therapy for prostate cancer. We investigated whether prostate-rectum spacers would enhance or diminish the benefits of anterior proton beams in these treatments. Twenty milliliters of hydrogel was injected between the prostate and rectum of a cadaver using a transperineal approach. Computed tomography (CT) and magnetic resonance (MR) images were used to generate 7 uniform scanning (US) and 7 single-field uniform dose pencil-beam scanning (PBS) plans with different beam arrangements. Pearson correlations were calculated between rectal, bladder, and femoral head dosimetric outcomes and beam arrangement anterior scores, which characterize the degree to which dose is delivered anteriorly. The overall quality of each plan was compared using a virtual dose-escalation study. For US plans, rectal mean dose was inversely correlated with anterior score, but for PBS plans there was no association between rectal mean dose and anterior score. For both US and PBS plans, full bladder and empty bladder mean doses were correlated with anterior scores. For both US and PBS plans, femoral head mean doses were inversely correlated with anterior score. For US plans and a full bladder, 4 beam arrangements that included an anterior beam tied for the highest maximum prescription dose (MPD). For US plans and an empty bladder, the arrangement with 1 anterior and 2 anterior oblique beams achieved the highest MPD in the virtual dose-escalation study. The dose-escalation study did not differentiate beam arrangements for PBS. All arrangements in the dose-escalation study were limited by bladder constraints except for the arrangement with 2 posterior oblique beams. The benefits of anterior proton beams in the setting of prostate-rectum spacers appear to be proton modality dependent and may not extend to PBS. PMID:23578497

  4. Stability, elastic and magnetostrictive properties of γ-Fe{sub 4}C and its derivatives from first principles theory

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yun; Wang, Zhe [Department of Physics, Xiangtan University, Xiangtan, 411105 Hunan (China); Cao, Juexian, E-mail: jxcao@xtu.edu.cn [Department of Physics, Xiangtan University, Xiangtan, 411105 Hunan (China); Beijing Computational Science Reasearch Center, 100084 Beijing (China)

    2014-11-15

    Using the first-principles full-potential linearized augmented plane-wave method, we investigated the stability, elastic and magnetostrictive properties of γ-Fe{sub 4}C and its derivatives. From the formation energy, we show that the most preferable configuration for MFe{sub 3}C (M=Pd, Pt, Rh, Ir) is that the M atom occupies the corner 1a position rather than 3c position. These derivatives are ductile due to high B/G values except for IrFe{sub 3}C. The calculated tetragonal magnetostrictive coefficient λ{sub 001} value for γ-Fe{sub 4}C is −380 ppm, which is larger than the value of Fe{sub 83}Ga{sub 17} (+207 ppm). Due to the strong SOC coupling strength constant (ξ) of Pt, the calculated λ{sub 001} of PtFe{sub 3}C is −691 ppm, which is increased by 80% compared to that of γ-Fe{sub 4}C. We demonstrate the origin of giant magnetostriction coefficient in terms of electronic structures and their responses to the tetragonal lattice distortion. - Highlights: • The most preferable site for M atom of MFe{sub 3}C (M=Pd, Pt, Rh, Ir) is the corner position. • The magnetostrictive coefficient for γ-Fe{sub 4}C is −380 ppm, larger than the value of Fe{sub 83}Ga{sub 17}. • The calculated λ{sub 001} of PtFe{sub 3}C is −691 ppm, which is increased by 80% compared to that of γ-Fe{sub 4}C.

  5. Theoretical and experimental study of low-finesse extrinsic Fabry-Perot interferometric fiber optic sensors

    Science.gov (United States)

    Han, Ming

    have less resolution, or are not capable of absolute measurement. Previous mathematical models for MMF-EFPI sensors are all based on geometric optics; therefore their applications have many limitations. In this dissertation, a modal theory is developed that can be used in any situations and is more accurate. The mathematical description of the spectral fringes of MMF-EFPI sensors is obtained by the modal theory. Effect on the fringe visibility of system parameters, including the sensor head structure, the fiber parameters, and the mode power distribution in the MMF of the MMF-EFPI sensors, is analyzed. Experiments were carried out to validate the theory. Fundamental mechanism that causes the degradation of the fringe visibility in MMF-EFPI sensors are revealed. It is shown that, in some situations at which the fringe visibility is important and difficult to achieve, a simple method of launching the light into the MMF-EFPI sensor system from the output of a SMF could be used to improve the fringe visibility and to ease the fabrication difficulties of MMF-EFPI sensors. Signal processing methods that are well-understood in white-light SMF-EFPI sensor systems may exhibit new aspects when they are applied to white-light MMF-EFPI sensor systems. This dissertation reveals that the variations of mode power distribution (MPD) in the MMF could cause phase variations of the spectral fringes from a MMF-EFPI sensor and introduce measurement errors for a signal processing method in which the phase information is used. This MPD effect on the wavelength-tracking method in white-light MMF-EFPI sensors is theoretically analyzed. The fringe phases changes caused by MPD variations were experimentally observed and thus the MFD effect is validated.

  6. A New Control Paradigm for Stochastic Differential Equations

    Science.gov (United States)

    Schmid, Matthias J. A.

    to scalar systems subject to state-dependent noise and to systems of higher order. The suggested control paradigm is further advanced when a sequential application of MLD control is considered. This technique yields a nominal path corresponding to the minimum total deviation probability on the entire time domain. It is demonstrated that this sequential optimization concept can be unified in a single objective function which is revealed to be the Jacobi field performance index on the entire domain subject to an endpoint deviation. The emerging closed-form term replaces the previously required nested optimization and, thus, results in a highly efficient application-ready control design. This effectively substantiates Minimum Path Deviation (MPD) control. The proposed control paradigm allows the specific problem of stochastic cost control to be addressed as a special case. This new technique is employed within this study for the stochastic cost problem giving rise to Cost Constrained MPD (CCMPD) as well as to Minimum Quadratic Cost Deviation (MQCD) control. An exemplary treatment of a generic scalar nonlinear system subject to quadratic costs is performed for MQCD control to demonstrate the elementary expandability of the new control paradigm. This work concludes with a numerical evaluation of both MPD and CCMPD control for three exemplary benchmark problems. Numerical issues associated with the simulation of SDEs are briefly discussed and illustrated. The numerical examples furnish proof of the successful design. This study is complemented by a thorough review of statistical control methods, stochastic processes, Large Deviations techniques and the Freidlin-Wentzell theory, providing a comprehensive, self-contained account. The presentation of the mathematical tools and concepts is of a unique character, specifically addressing an engineering audience.

  7. WE-AB-204-06: Pseudo-CT Generation Using Undersampled, Single-Acquisition UTE-MDixon and Direct-Mapping Artificial Neural Networks for MR-Based Attenuation Correction and Radiation Therapy Planning

    Energy Technology Data Exchange (ETDEWEB)

    Su, K; Kuo, J [Case Center for Imaging Research, Case Western Reserve University, Cleveland, Ohio (United States); Department of Radiology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio (United States); Hu, L; Traughber, M [Philips Healthcare, Cleveland, Ohio (United States); Pereira, G; Traughber, B [Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, Ohio (United States); Herrmann, K [Department of Radiology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio (United States); Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio (United States); Muzic, R [Case Center for Imaging Research, Case Western Reserve University, Cleveland, Ohio (United States); Department of Radiology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio (United States); Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH (United States)

    2015-06-15

    Purpose: Emerging technologies such as dedicated PET/MRI and MR-therapy systems require robust and clinically practical methods for determining photon attenuation. Herein, we propose using novel MR acquisition methods and processing for the generation of pseudo-CTs. Methods: A single acquisition, 190-second UTE-mDixon sequence with 25% (angular) sampling density and 3D radial readout was performed on nine volunteers. Three water-filled tubes were placed in the FOV for trajectory-delay correction. The MR data were reconstructed to generate three primitive images acquired at TEs of 0.1, 1.5 and 2.8 ms. In addition, three derived MR images were generated, i.e. two-point Dixon water/fat separation and R2* (1/T2*) map. Furthermore, two spatial features, i.e. local binary pattern (S-1) and relative spatial coordinates (S-2), were incorporated. A direct-mapping operator was generated using Artificial Neural Networks (ANNs) for transforming the MR features to a pseudo-CT. CT images served as the training data and, using a leave-one-out method, for performance evaluation using mean prediction deviation (MPD), mean absolute prediction deviation (MAPD), and correlation coefficient (R). Results: The errors between measured CT and pseudo-CT declined dramatically when the spatial features, i.e. S-1 and S-2, were included. The MPD, MAPD, and R were, respectively, 5±57 HU, 141±41 HU, and 0.815±0.066 for results generated by the ANN trained without the spatial features and were 32±26 HU, 115±18 HU, and 0.869±0.035 with the spatial features. The estimation errors of the pseudo-CT were smaller when both the S-1 and S-2 were used together than when either the S-1 or the S-2 was used. Pseudo-CT generation (256×256×256 voxels) by ANN took < 0.5 s using a computer having an Intel i7 3.4GHz CPU and 16 GB RAM. Conclusion: The proposed direct-mapping ANN approach is a technically accurate, clinically practical method for pseudo-CT generation and can potentially help improve the

  8. Posttreatment biopsy results following interstitial brachytherapy in early-stage prostate cancer

    International Nuclear Information System (INIS)

    Prestidge, Bradley R.; Hoak, David C.; Grimm, Peter D.; Ragde, Haakon; Cavanagh, William; Blasko, John C.

    1997-01-01

    Purpose: To assess pathologic control rates for prostatic carcinoma as determined by postimplant prostate biopsy in a large series of consecutive patients who have received permanent interstitial brachytherapy using a contemporary transrectal ultrasound-directed, transperineal, computer generated, volume technique. Methods and Materials: Four hundred and two patients received permanent 125 I or 103 Pd interstitial brachytherapy as primary treatment for early stage prostatic carcinoma at the Northwest Tumor Institute between January 1988 and January 1994. Of these, 201 have consented to biopsy 12 or more months postimplant with a median follow-up of 40 months (range: 12-83 months). None had received homonal manipulation. A total of 361 biopsies was performed on 201 patients with a range of one to six annual biopsies per patient (91 received multiple, serial biopsies). Of the 161 patients more than 12 months postimplant who have not been biopsied, most have been unwilling or unable to submit to biopsy. Only six patients with biochemical progression have not been biopsied. There was no difference in the presenting characteristics or implant parameters between those patients biopsied and those that were not. One hundred and forty-three received 125 I (71%) prescribed to a MPD of 160 Gy with a median activity of 35.5 mCi, and 58 (29%) received 103 Pd prescribed to a MPD of 115 Gy with a median activity of 123 mCi. Multiple biopsies were performed under transrectal ultrasound guidance, and all specimens were classified as either negative, indeterminate, or positive. Results: At the time of last biopsy, 161 (80%) have achieved negative pathology, 34 (17%) remain indeterminate, and 6 (3%) have been positive. Only 2 of the 186 patients with a PSA < 4.0 ng/ml at the time of biopsy were positive. Among those 33 indeterminate patients with a subsequent biopsy, 28 have converted to negative, 2 to positive, and 3 remain unchanged to date. Conclusions: These data demonstrate at

  9. Battery-operated, argon-hydrogen microplasma on hybrid, postage stamp-sized plastic-quartz chips for elemental analysis of liquid microsamples using a portable optical emission spectrometer.

    Science.gov (United States)

    Weagant, Scott; Chen, Vivian; Karanassios, Vassili

    2011-11-01

    A battery-operated, atmospheric pressure, self-igniting, planar geometry Ar-H(2) microplasma for elemental analysis of liquid microsamples is described. The inexpensive microplasma device (MPD) fabricated for this work was a hybrid plastic-quartz structure that was formed on chips with an area (roughly) equal to that of a small-sized postage stamp (MPD footprint, 12.5-mm width by 38-mm length). Plastic substrates were chosen due to their low cost, for rapid prototyping purposes, and for a speedy microplasma device evaluation. To enhance portability, the microplasma was operated from an 18-V rechargeable battery. To facilitate portability even further, it was demonstrated that the battery can be recharged by a portable solar panel. The battery-supplied dc voltage was converted to a high-voltage ac. The ~750-μm (diameter) and 12-mm (long) Ar-H(2) (3% H(2)) microplasma was formed by applying the high-voltage ac between two needle electrodes. Spectral interference from the electrode materials or from the plastic substrate was not observed. Operating conditions were found to be key to igniting and sustaining a microplasma that was simply "warm" to the touch (thus alleviating the need for cooling or other thermal management) and that had a stable background emission. A small-sized (900 μL internal volume) electrothermal vaporization system (40-W max power) was used for microsample introduction. Microplasma background emission in the spectral region between 200 and 850 nm obtained using a portable fiber-optic spectrometer is reported and the effect of the operating conditions is described. Analyte emission from microliter volumes of dilute single-element standard solutions of Cd, Cu, K, Li, Mg, Mn, Na, Pb, and Zn is documented. The majority of spectral lines observed for the elements tested were from neutral atoms. The relative lack of emission from ion lines simplified the spectra, thus facilitating the use of a portable spectrometer. Despite the relative spectral

  10. WE-AB-204-06: Pseudo-CT Generation Using Undersampled, Single-Acquisition UTE-MDixon and Direct-Mapping Artificial Neural Networks for MR-Based Attenuation Correction and Radiation Therapy Planning

    International Nuclear Information System (INIS)

    Su, K; Kuo, J; Hu, L; Traughber, M; Pereira, G; Traughber, B; Herrmann, K; Muzic, R

    2015-01-01

    Purpose: Emerging technologies such as dedicated PET/MRI and MR-therapy systems require robust and clinically practical methods for determining photon attenuation. Herein, we propose using novel MR acquisition methods and processing for the generation of pseudo-CTs. Methods: A single acquisition, 190-second UTE-mDixon sequence with 25% (angular) sampling density and 3D radial readout was performed on nine volunteers. Three water-filled tubes were placed in the FOV for trajectory-delay correction. The MR data were reconstructed to generate three primitive images acquired at TEs of 0.1, 1.5 and 2.8 ms. In addition, three derived MR images were generated, i.e. two-point Dixon water/fat separation and R2* (1/T2*) map. Furthermore, two spatial features, i.e. local binary pattern (S-1) and relative spatial coordinates (S-2), were incorporated. A direct-mapping operator was generated using Artificial Neural Networks (ANNs) for transforming the MR features to a pseudo-CT. CT images served as the training data and, using a leave-one-out method, for performance evaluation using mean prediction deviation (MPD), mean absolute prediction deviation (MAPD), and correlation coefficient (R). Results: The errors between measured CT and pseudo-CT declined dramatically when the spatial features, i.e. S-1 and S-2, were included. The MPD, MAPD, and R were, respectively, 5±57 HU, 141±41 HU, and 0.815±0.066 for results generated by the ANN trained without the spatial features and were 32±26 HU, 115±18 HU, and 0.869±0.035 with the spatial features. The estimation errors of the pseudo-CT were smaller when both the S-1 and S-2 were used together than when either the S-1 or the S-2 was used. Pseudo-CT generation (256×256×256 voxels) by ANN took < 0.5 s using a computer having an Intel i7 3.4GHz CPU and 16 GB RAM. Conclusion: The proposed direct-mapping ANN approach is a technically accurate, clinically practical method for pseudo-CT generation and can potentially help improve the

  11. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.

    Science.gov (United States)

    Pikman, Yana; Lee, Benjamin H; Mercher, Thomas; McDowell, Elizabeth; Ebert, Benjamin L; Gozo, Maricel; Cuker, Adam; Wernig, Gerlinde; Moore, Sandra; Galinsky, Ilene; DeAngelo, Daniel J; Clark, Jennifer J; Lee, Stephanie J; Golub, Todd R; Wadleigh, Martha; Gilliland, D Gary; Levine, Ross L

    2006-07-01

    The JAK2V617F allele has recently been identified in patients with polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis with myeloid metaplasia (MF). Subsequent analysis has shown that constitutive activation of the JAK-STAT signal transduction pathway is an important pathogenetic event in these patients, and that enzymatic inhibition of JAK2V617F may be of therapeutic benefit in this context. However, a significant proportion of patients with ET or MF are JAK2V617F-negative. We hypothesized that activation of the JAK-STAT pathway might also occur as a consequence of activating mutations in certain hematopoietic-specific cytokine receptors, including the erythropoietin receptor (EPOR), the thrombopoietin receptor (MPL), or the granulocyte-colony stimulating factor receptor (GCSFR). DNA sequence analysis of the exons encoding the transmembrane and juxtamembrane domains of EPOR, MPL, and GCSFR, and comparison with germline DNA derived from buccal swabs, identified a somatic activating mutation in the transmembrane domain of MPL (W515L) in 9% (4/45) of JAKV617F-negative MF. Expression of MPLW515L in 32D, UT7, or Ba/F3 cells conferred cytokine-independent growth and thrombopoietin hypersensitivity, and resulted in constitutive phosphorylation of JAK2, STAT3, STAT5, AKT, and ERK. Furthermore, a small molecule JAK kinase inhibitor inhibited MPLW515L-mediated proliferation and JAK-STAT signaling in vitro. In a murine bone marrow transplant assay, expression of MPLW515L, but not wild-type MPL, resulted in a fully penetrant myeloproliferative disorder characterized by marked thrombocytosis (Plt count 1.9-4.0 x 10(12)/L), marked splenomegaly due to extramedullary hematopoiesis, and increased reticulin fibrosis. Activation of JAK-STAT signaling via MPLW515L is an important pathogenetic event in patients with JAK2V617F-negative MF. The bone marrow transplant model of MPLW515L-mediated myeloproliferative disorders (MPD) exhibits certain features of human MF

  12. Left-Right Asymmetry in Spectral Characteristics of Lung Sounds Detected Using a Dual-Channel Auscultation System in Healthy Young Adults.

    Science.gov (United States)

    Tsai, Jang-Zern; Chang, Ming-Lang; Yang, Jiun-Yue; Kuo, Dar; Lin, Ching-Hsiung; Kuo, Cheng-Deng

    2017-06-07

    Though lung sounds auscultation is important for the diagnosis and monitoring of lung diseases, the spectral characteristics of lung sounds have not been fully understood. This study compared the spectral characteristics of lung sounds between the right and left lungs and between healthy male and female subjects using a dual-channel auscultation system. Forty-two subjects aged 18-22 years without smoking habits and any known pulmonary diseases participated in this study. The lung sounds were recorded from seven pairs of auscultation sites on the chest wall simultaneously. We found that in four out of seven auscultation pairs, the lung sounds from the left lung had a higher total power (P T ) than those from the right lung. The P T of male subjects was higher than that of female ones in most auscultation pairs. The ratio of inspiration power to expiration power (R I/E ) of lung sounds from the right lung was greater than that from the left lung at auscultation pairs on the anterior chest wall, while this phenomenon was reversed at auscultation pairs on the posterior chest wall in combined subjects, and similarly in both male and female subjects. Though the frequency corresponding to maximum power density of lung sounds (F MPD ) from the left and right lungs was not significantly different, the frequency that equally divided the power spectrum of lung sounds (F 50 ) from the left lung was significantly smaller than that from the right lung at auscultation site on the anterior and lateral chest walls, while it was significantly larger than that of from the right lung at auscultation site on the posterior chest walls. In conclusion, significant differences in the P T , F MPD , F 50 , and R I/E between the left and right lungs at some auscultation pairs were observed by using a dual-channel auscultation system in this study. Structural differences between the left and the right lungs, between the female and male subjects, and between anterior and posterior lungs might

  13. Effect of Dietary Supplementation With Lutein, Zeaxanthin, and ω-3 on Macular Pigment: A Randomized Clinical Trial.

    Science.gov (United States)

    Korobelnik, Jean-François; Rougier, Marie-Bénédicte; Delyfer, Marie-Noëlle; Bron, Alain; Merle, Bénédicte M J; Savel, Hélène; Chêne, Geneviève; Delcourt, Cécile; Creuzot-Garcher, Catherine

    2017-11-01

    Nutritional uptake of lutein, zeaxanthin, and ω-3 polyunsaturated fatty acids may increase macular pigment optical density (MPOD) and thereby protect against the development of age-related macular degeneration (AMD). To estimate the efficiency of dietary supplementation containing lutein, zeaxanthin, ω-3 polyunsaturated fatty acids, and vitamins to increase the density of macular pigment in first-generation offspring of parents with neovascular AMD. This study was a randomized clinical trial (Lutein Influence on Macula of Persons Issued From AMD Parents [LIMPIA]) with a 6-month treatment period, followed by a 6-month follow-up period. Analyses were based on the intent-to-treat principle. The setting was 2 university hospitals in France (at Bordeaux and Dijon) from January 2011 (first participant first visit) to February 2013 (last participant last visit). The analysis was conducted from January to November 2016. Participants were 120 individuals free of any retinal ocular disease. They were first-generation offspring of parents with neovascular AMD. Participants were randomized in a 1:1 ratio to receive either 2 daily dietary supplementation capsules or placebo for 6 months. The primary assessment criterion was the evolution of MPOD after 6 months of supplementation (value of both eligible eyes) measured using the modified MPD-Visucam 200 (Carl Zeiss Meditec) and the modified Heidelberg Retina Angiograph (Heidelberg Engineering) (HRA) at 0.98° eccentricity. The statistical analysis was adjusted for hospital and for risk factors. Overall, 120 participants (60 in each group) were included, and 239 eyes were analyzed (119 in the lutein plus zeaxanthin [L + Z] group and 120 in the placebo group). Their mean (SD) age was 56.7 (6.6) years, and 71.7% (n = 86) were female. A statistically significant increase in plasma lutein and zeaxanthin was shown in the L + Z group after 3 months and 6 months of treatment compared with the placebo group. However, the

  14. Additional value of FDG PET/CT to contrast-enhanced CT in the differentiation between benign and malignant intraductal papillary mucinous neoplasms of the pancreas with mural nodules

    International Nuclear Information System (INIS)

    Takanami, Kentaro; Hiraide, Tomomichi; Tsuda, Masashi; Nakamura, Yausuhiro; Kaneta, Tomohiro; Takase, Kei; Takahashi, Shoki; Fukuda, Hiroshi

    2011-01-01

    This study aimed at determining the additional value of F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT to contrast-enhanced CT in the differentiation between benign and malignant intraductal papillary mucinous neoplasms (IPMNs) of the pancreas with mural nodules. This retrospective review of medical records was approved by our institutional review board. The preoperative PET/CT images of 16 non-diabetic patients with surgically proven IPMN, where mural nodules of 3 mm or larger were shown by preoperative contrast-enhanced CT, were retrospectively evaluated. The 16 patients were divided into two groups: 7 patients with benign IPMN [adenoma (n=1) and borderline tumor (n=6)] and 9 patients with malignant IPMN [carcinoma in situ (CIS) (n=8) and invasive carcinoma (n=1)]. Nuclear medicine physician blinded to the pathologic assessment of malignancy of IPMN set a spherical volume of interest (VOI) over the mural nodules on PET/CT images and recorded the peak standardized uptake value (SUV max ) in the VOI, referring the contrast-enhanced CT images. Statistical differences in the size of mural nodule, the diameter of main pancreatic duct (MPD), and SUV max of the tumors between benign IPMNs and malignant IPMNs were compared using the Mann-Whitney U test. Statistical significance was set at p max of the malignant IPMNs with mural nodules of 3 mm or larger was higher than that of benign IPMNs (2.7±0.6 vs. 1.9±0.3, p<0.01). Meanwhile, there was no significant difference in mural nodule diameter and MPD diameter between the two groups. FDG PET/CT showed an excellent diagnostic accuracy for the differentiation between malignant and benign IPMNs with mural nodules: the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy in malignant IPMN with mural nodule of FDG PET/CT were 77.8, 100, 100, 77.8, and 87.5 for the cutoff value of 2.3; and 100, 57.1, 75.0, 100, and 81.3 for the cutoff value of 2

  15. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.

    Directory of Open Access Journals (Sweden)

    Yana Pikman

    2006-07-01

    Full Text Available The JAK2V617F allele has recently been identified in patients with polycythemia vera (PV, essential thrombocytosis (ET, and myelofibrosis with myeloid metaplasia (MF. Subsequent analysis has shown that constitutive activation of the JAK-STAT signal transduction pathway is an important pathogenetic event in these patients, and that enzymatic inhibition of JAK2V617F may be of therapeutic benefit in this context. However, a significant proportion of patients with ET or MF are JAK2V617F-negative. We hypothesized that activation of the JAK-STAT pathway might also occur as a consequence of activating mutations in certain hematopoietic-specific cytokine receptors, including the erythropoietin receptor (EPOR, the thrombopoietin receptor (MPL, or the granulocyte-colony stimulating factor receptor (GCSFR.DNA sequence analysis of the exons encoding the transmembrane and juxtamembrane domains of EPOR, MPL, and GCSFR, and comparison with germline DNA derived from buccal swabs, identified a somatic activating mutation in the transmembrane domain of MPL (W515L in 9% (4/45 of JAKV617F-negative MF. Expression of MPLW515L in 32D, UT7, or Ba/F3 cells conferred cytokine-independent growth and thrombopoietin hypersensitivity, and resulted in constitutive phosphorylation of JAK2, STAT3, STAT5, AKT, and ERK. Furthermore, a small molecule JAK kinase inhibitor inhibited MPLW515L-mediated proliferation and JAK-STAT signaling in vitro. In a murine bone marrow transplant assay, expression of MPLW515L, but not wild-type MPL, resulted in a fully penetrant myeloproliferative disorder characterized by marked thrombocytosis (Plt count 1.9-4.0 x 10(12/L, marked splenomegaly due to extramedullary hematopoiesis, and increased reticulin fibrosis.Activation of JAK-STAT signaling via MPLW515L is an important pathogenetic event in patients with JAK2V617F-negative MF. The bone marrow transplant model of MPLW515L-mediated myeloproliferative disorders (MPD exhibits certain features of

  16. NILAI EKONOMI KARBON HUTAN RAWA GAMBUT MERANG KEPAYANG, PROVINSI SUMATERA SELATAN (Economic Value of Carbon of Merang Kepayang Peat Swamp Forest, South Sumatera Province

    Directory of Open Access Journals (Sweden)

    Nur Arifatul Ulya

    2015-03-01

    Full Text Available ABSTRAK Hutan rawa gambut menyimpan cadangan karbon baik di tanah maupun di atas tanah. Hutan Rawa Gambut Merang Kepayang (HRGMK merupakan kawasan hutan yang berada di kubah gambut terbesar di Sumatera Selatan, yaitu Kubah Gambut Merang (KGM, yang didalamnya terdapat gambut dengan ketebalan lebih dari 3 meter. Meskipun menurut aturan KGM seharusnya dikonservasi, pada kenyataannya kawasan HRGMK dihadapkan pada konversi. Konversi HRGMK diduga akan mengakibatkan terganggunya fungsi hutan rawa gambut sebagai cadangan karbon dunia sehingga akan menyebabkan terjadinya emisi karbon ke atmosfer dalam jumlah besar. Penelitian ini bertujuan untuk mengetahui nilai ekonomi kawasan HRGMK sebagai penyimpan cadangan karbon. Hasil penelitian diharapkan menjadi acuan pelestarian HRGMK sebagai stabilisator iklim dunia. Nilai ekonomi karbon HRGMK ditaksir dengan menggunakan harga bayangan. Harga karbon yang digunakan untuk menaksir nilai ekonomi karbon diperoleh dengan metode benefit transfer. Hasil penelitian menunjukkan bahwa nilai total karbon HRGMK adalah US$ 1.591.878.378,00 atau Rp. 14.002.162.211.645,00. Nilai tersebut sebagian besar berasal dari cadangan karbon di bawah tanah. ABSTRACT Peat swamp forests store aboveground and belowground carbon. Merang Kepayang Peat Swamp Forest (MKPSF is a forest area which is located in Merang Peat Dome (MPD, the largest peat dome in South Sumatra, with peat thickness more than 3 meters. Although the order should be conserved MPD, in fact MKPSF area exposed to the conversion. MKPSF conversion would presumably result in impaired function of peat swamp forest as world's carbon storage that will be caused carbon emissions into the atmosphere in large quantities. This study aimed to determine the economic value of the HRGMK as carbon storage. The results are expected to be justifications for conservation of MKPSF as climate stabilizers. The economic value of carbon HRGMK assessed using shadow pricing method. The carbon price

  17. Comparative evolutionary diversity and phylogenetic structure across multiple forest dynamics plots: a mega-phylogeny approach

    Science.gov (United States)

    Erickson, David L.; Jones, Frank A.; Swenson, Nathan G.; Pei, Nancai; Bourg, Norman A.; Chen, Wenna; Davies, Stuart J.; Ge, Xue-jun; Hao, Zhanqing; Howe, Robert W.; Huang, Chun-Lin; Larson, Andrew J.; Lum, Shawn K. Y.; Lutz, James A.; Ma, Keping; Meegaskumbura, Madhava; Mi, Xiangcheng; Parker, John D.; Fang-Sun, I.; Wright, S. Joseph; Wolf, Amy T.; Ye, W.; Xing, Dingliang; Zimmerman, Jess K.; Kress, W. John

    2014-01-01

    Forest dynamics plots, which now span longitudes, latitudes, and habitat types across the globe, offer unparalleled insights into the ecological and evolutionary processes that determine how species are assembled into communities. Understanding phylogenetic relationships among species in a community has become an important component of assessing assembly processes. However, the application of evolutionary information to questions in community ecology has been limited in large part by the lack of accurate estimates of phylogenetic relationships among individual species found within communities, and is particularly limiting in comparisons between communities. Therefore, streamlining and maximizing the information content of these community phylogenies is a priority. To test the viability and advantage of a multi-community phylogeny, we constructed a multi-plot mega-phylogeny of 1347 species of trees across 15 forest dynamics plots in the ForestGEO network using DNA barcode sequence data (rbcL, matK, and psbA-trnH) and compared community phylogenies for each individual plot with respect to support for topology and branch lengths, which affect evolutionary inference of community processes. The levels of taxonomic differentiation across the phylogeny were examined by quantifying the frequency of resolved nodes throughout. In addition, three phylogenetic distance (PD) metrics that are commonly used to infer assembly processes were estimated for each plot [PD, Mean Phylogenetic Distance (MPD), and Mean Nearest Taxon Distance (MNTD)]. Lastly, we examine the partitioning of phylogenetic diversity among community plots through quantification of inter-community MPD and MNTD. Overall, evolutionary relationships were highly resolved across the DNA barcode-based mega-phylogeny, and phylogenetic resolution for each community plot was improved when estimated within the context of the mega-phylogeny. Likewise, when compared with phylogenies for individual plots, estimates of

  18. Characterization and Evaluation of the Improved Performance of Modified Reverse Osmosis Membranes by Incorporation of Various Organic Modifiers and SnO2 Nanoparticles

    Directory of Open Access Journals (Sweden)

    Kh. M. AL-Sheetan

    2015-01-01

    Full Text Available Reverse osmosis (RO membranes modified with SnO2 nanoparticles of varied concentrations (0.001–0.1 wt.% were developed via in situ interfacial polymerization (IP of trimesoyl chloride (TMC and m-phenylenediamine (MPD on nanoporous polysulfone supports. The nanoparticles dispersed in the dense nodular polyamide on the polysulfone side. The effects of IP reaction time and SnO2 loading on membrane separation performance were studied. The modified reverse osmosis membranes were characterized by scanning electron microscopy (SEM, X-ray diffractometer (XRD, energy dispersive X-ray spectroscopy (EDX, transmission electron microscopy (TEM, contact angle measurement, and atomic force microscopy (AFM. The synthesized SnO2 nanoparticles size varies between 10 and 30 nm. The results exhibited a smooth membrane surface and average surface roughness from 31 to 68 nm. Moreover, hydrophilicity was enhanced and contact angle decreased. The outcomes showed that an IP reaction time was essential to form a denser SnO2-polyamide layer for higher salt rejection, the developed reverse osmosis membranes with the incorporation of the SnO2 nanoparticles were examined by measuring permeate fluxes and salt rejection, and the permeate flux increased from 26 to 43.4 L/m2·h, while salt rejection was high at 98% (2000 ppm NaCl solution at 225 psi (1.55 MPa, 25°C.

  19. X-ray studies of recombinant anti-testosterone Fab fragments: the use of PEG 3350 in crystallization.

    Science.gov (United States)

    Valjakka, J; Hemminki, A; Teerinen, T; Takkinen, K; Rouvinen, J

    2000-02-01

    Recombinant anti-testosterone wild-type Fab fragment and mutant Fab fragments with high binding selectivity developed by protein engineering have been crystallized with and without ligands. Crystals of these Fab fragments were obtained by the vapour-diffusion technique at room temperature using solutions of PEG 3350 with various biological buffers and with a wide pH range. So far, five data sets have been collected from crystals of three Fab-antigen complexes and from two uncomplexed Fab fragments, with resolutions ranging from 2.10 to 3.1 A. Crystallization conditions for Fab fragments were found by using modifications of the low ionic strength PEG 3350 series. Suitable concentrations of PEG 400, MPD and glycerol solutions for use as cryoprotectants in PEG 3350 solutions have been determined. One useful observation was that PEG 3350 is able to work alone as a cryoprotectant. The screening protocol used requires a smaller amount of protein material to achieve auspicious pre-crystals than previously. Results support the claim that PEG 3350 is more suitable for the crystallization of Fab fragments than higher molecular weight PEGs.

  20. Prospects for improved fusion reactors

    International Nuclear Information System (INIS)

    Krakowski, R.A.; Miller, R.L.; Hagenson, R.L.

    1986-01-01

    Ideally, a new energy source must be capable of displacing old energy sources while providing both economic opportunities and enhanced environmental benefits. The attraction of an essentially unlimited fuel supply has generated a strong impetus to develop advanced fission breeders and, even more strongly, the exploitation of nuclear fusion. Both fission and fusion systems trade a reduced fuel charge for a more capital-intensive plant needed to utilize a cheaper and more abundant fuel. Results from early conceptual designs of fusion power plants, however, indicated a capital intensiveness that could override cost savings promised by an inexpensive fuel cycle. Early warnings of these problems appeared, and generalized routes to more economically attractive systems have been suggested; specific examples have also recently been given. Although a direct reduction in the cost (and mass) of the fusion power core (FPC, i.e., plasma chamber, first wall, blanket, shield, coils, and primary structure) most directly reduces the overall cost of fusion power, with the mass power density (MPD, ratio of net electric power to FPC mass, kWe/tonne) being suggested as a figure-of-merit in this respect, other technical, safety/environmental, and institutional issues also enter into the definition of and direction for improved fusion concepts. These latter issues and related tradeoffs are discussed

  1. Theoretical studies of the work functions of Pd-based bimetallic surfaces

    International Nuclear Information System (INIS)

    Ding, Zhao-Bin; Wu, Feng; Wang, Yue-Chao; Jiang, Hong

    2015-01-01

    Work functions of Pd-based bimetallic surfaces, including mainly M/Pd(111), Pd/M, and Pd/M/Pd(111) (M = 4d transition metals, Cu, Au, and Pt), are studied using density functional theory. We find that the work function of these bimetallic surfaces is significantly different from that of parent metals. Careful analysis based on Bader charges and electron density difference indicates that the variation of the work function in bimetallic surfaces can be mainly attributed to two factors: (1) charge transfer between the two different metals as a result of their different intrinsic electronegativity, and (2) the charge redistribution induced by chemical bonding between the top two layers. The first factor can be related to the contact potential, i.e., the work function difference between two metals in direct contact, and the second factor can be well characterized by the change in the charge spilling out into vacuum. We also find that the variation in the work functions of Pd/M/Pd(111) surfaces correlates very well with the variation of the d-band center of the surface Pd atom. The findings in this work can be used to provide general guidelines to design new bimetallic surfaces with desired electronic properties

  2. Metaphorical profile of distress in English media discourse

    Directory of Open Access Journals (Sweden)

    Verbytska Anna

    2017-12-01

    Full Text Available The current research is directed towards the transition of distress studies in the English speaking culture from the prototype towards the conceptual metaphor approach. It enables the enlightenment of mental images, which underlie distress language usage in modern mass communication. The analysis involves identification of conceptual distress metaphors and metonymies within the image-schematic structure. The study includes a cognitive semantic analysis of linguistic units of the distress lexicon retrieved from the GloWbE, BNC, COCA, English newspapers and media platforms. Figurative language reveals conventional beliefs about distress represented in English media discourse, such as strong associations of emotion with darkness and coldness. Metaphorical mappings contain views about the reasons for distress experience which lie in the loss of balance or inner equilibrium, loss of control, and convictions about the reaction characterizing a person as being weak and brittle. The findings of data analysis are summed up in a metaphorical profile of distress (MPD which discloses the behavioural patterns (communicative behaviour, adequacy/inadequacy of behaviour, ability to socialize and physical effects including health issues.

  3. Comparison of the performance and EIS (electrochemical impedance spectroscopy) response of an activated PEMFC (proton exchange membrane fuel cell) under low and high thermal and pressure stresses

    International Nuclear Information System (INIS)

    Zhiani, Mohammad; Majidi, Somayeh; Silva, Valter Bruno; Gharibi, Hussein

    2016-01-01

    In this study, it was demonstrated that membrane electrode assembly (MEA) conditioning at the low stress condition produces a higher performance compared to MEA conditioning under the high stress condition, although it needs more time to accomplish. The maximum power density (MPD) of 1600 mW cm"−"2 was achieved by the MEA activated at low temperature and pressure (MEA-LTP) compared to the MEA activated at high temperature and pressure (MEA-HTP) in the same operating conditions, 1090 mW cm"−"2, whiles the MEA structure of both cells was identical. MEA conditioning at the low stress condition enhances not only the fuel cell power but also its energy efficiency by 25%. Comparison of electrochemical impedance spectroscopy (EIS) responses of MEA-LTP and MEA-HTP indicated that an extension of the triple phase boundary occurred in MEA-LTP, which was consistent with the results of the MEA performance analysis. - Highlights: • MEA activation at low and high P and T was studied and compared. • High steady state performance achieved by the activated MEA at low P and T. • Low R_c_t and R_m_t obtained by the activated MEA at low P and T. • Low stress condition for MEA activation is more effective than high stress status.

  4. Acceleration Modes and Transitions in Pulsed Plasma Accelerators

    Science.gov (United States)

    Polzin, Kurt A.; Greve, Christine M.

    2018-01-01

    Pulsed plasma accelerators typically operate by storing energy in a capacitor bank and then discharging this energy through a gas, ionizing and accelerating it through the Lorentz body force. Two plasma accelerator types employing this general scheme have typically been studied: the gas-fed pulsed plasma thruster and the quasi-steady magnetoplasmadynamic (MPD) accelerator. The gas-fed pulsed plasma accelerator is generally represented as a completely transient device discharging in approximately 1-10 microseconds. When the capacitor bank is discharged through the gas, a current sheet forms at the breech of the thruster and propagates forward under a j (current density) by B (magnetic field) body force, entraining propellant it encounters. This process is sometimes referred to as detonation-mode acceleration because the current sheet representation approximates that of a strong shock propagating through the gas. Acceleration of the initial current sheet ceases when either the current sheet reaches the end of the device and is ejected or when the current in the circuit reverses, striking a new current sheet at the breech and depriving the initial sheet of additional acceleration. In the quasi-steady MPD accelerator, the pulse is lengthened to approximately 1 millisecond or longer and maintained at an approximately constant level during discharge. The time over which the transient phenomena experienced during startup typically occur is short relative to the overall discharge time, which is now long enough for the plasma to assume a relatively steady-state configuration. The ionized gas flows through a stationary current channel in a manner that is sometimes referred to as the deflagration-mode of operation. The plasma experiences electromagnetic acceleration as it flows through the current channel towards the exit of the device. A device that had a short pulse length but appeared to operate in a plasma acceleration regime different from the gas-fed pulsed plasma

  5. Report on the environmental safety evaluation sub-committee in fiscal 1992; 1992 nendo kankyo anzensei hyoka bukai hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-03-01

    This paper reports the activities of the environmental safety evaluation sub-committee for the coal liquefaction plant in fiscal 1992. The sub-committee, upon having received reports on the result of environmental safety evaluation tests performed in fiscals 1991 and 1992 by NEDO, deliberated and discussed carefully the contents thereof. In order to ensure labor hygiene for coal liquefaction plant workers, health influence on liquefied oil users, and social acceptability of the liquefied oil, NEDO has performed the comprehensive brown coal pilot plant operation and oil safety tests. The tests are in accordance with the labor safety and hygiene law, the chemicals examination law, and the MPD issued by OECD, and performed on each fraction produced in the pilot plant and the whole fraction mixing the former fractions, using rats, rabbits, and guinea pigs. The test items included: acute inhalation toxicity and oral repeated administration (using rats); eye stimulation, repeated coating and skin stimulation (using rabbits); photo-toxicity (using guinea pigs); mutagenicity tests (microorganisms, bacteria and chromosome anomaly); resolution tests; fish toxicity; concentration degrees; algae growth obstruction; and water flea breeding obstruction. As the result, the toxicity was found light. (NEDO)

  6. Mefenamic acid conjugates based on a hydrophilic biopolymer hydroxypropylcellulose: novel prodrug design, characterization and thermal analysis

    International Nuclear Information System (INIS)

    Hussain, M.A.; Kausar, R.; Amin, M.

    2015-01-01

    Macromolecular prodrugs (MPDs) of mefenamic acid were designed onto a cellulose ether derivative hydroxypropylcellulose (HPC) as ester conjugates. Fabrication of HPC-mefenamic acid conjugates was achieved by using p-toluenesulfonyl chloride as carboxylic acid (a functional group in drug) activator at 80 degree C for 24 h under nitrogen atmosphere. Reaction was preceded under homogeneous reaction conditions as HPC was dissolved before use in DMAc solvent. Imidazole was used as a base. Easy workup reactions resulted in good yields (55-65%) and degree of substitution (DS) of drug (0.37-0.99) onto HPC. The DS was calculated by acid-base titration after saponification and UV/Vis spectrophotometry after hydrolysis. DS by both of the methods was found in good agreement with each other. Aqueous and organic soluble novel prodrugs of mefenamic acid were purified and characterized by different spectroscopic and thermal analysis techniques. The initial, maximum and final degradation temperatures of HPC, mefenamic acid and HPC-mefenamic acid conjugates were drawn from thermogravimetric (TG) and derivative TG curves and compared to access relative thermal stability. The TG analysis has indicated that samples obtained were thermally more stable especially with increased stability of mefenamic acid in HPC-mefenamic acid conjugates. These novel MPDs of mefenamic acid (i.e., HPC-mefenamic acid conjugates) may have potential applications in pharmaceutically viable drug design due to wide range of solubility and extra thermal stability imparted after MPD formation. (author)

  7. Modification of Polyamide-Urethane (PAUt Thin Film Composite Membrane for Improving the Reverse Osmosis Performance

    Directory of Open Access Journals (Sweden)

    Li-Fen Liu

    2018-03-01

    Full Text Available In the current study, the poly (amide-urethane (PAUt membranes were successfully fabricated by interfacial polymerization of m-phenylenediamine (MPD and 5-choroformyloxyisophaloyl chloride (CFIC on the polysulfone substrates. Two modification methods based on layer-by-layer assembly were applied to modify the PAUt membrane surface to achieve antifouling property: 1. Chitosan (CS was directly self-assembled on the PAUt membrane (i.e., PAUt-CS; and 2. polydimethyl diallyl ammonium chloride (PDDA, polystyrene sulfonate (PSS, and CS were successively self-assembled on the membrane surface (i.e., PAUt-PDDA/PSS/CS. The resultant membranes were symmetrically characterized by Attenuated Total Reflection Fourier Transform Infrared Spectroscopy (ATR-FTIR, X-ray Photoelectron Spectroscopy (XPS, Scanning Electron Microscopy (SEM, Atomic Force Microscopy (AFM and Contact Angle Meter (CAM, respectively. The results indicated that the modified membranes had much smoother and more hydrophilic surfaces as compared to the nascent PAUt membrane. Meanwhile, the modified membranes exhibited better reverse osmosis performance in terms of water permeability and salt rejection. After the modified membranes were fouled by lake water, the PAUt-PDDA/PSS/CS membrane presented the best antifouling performance among the three types of membranes. Combining the reverse osmosis performance with the anti-fouling property obviously, the PAUt-PDDA/PSS/CS membrane behaved as a promising candidate to be used in real applications.

  8. Biodegradation of chlorpyrifos and its hydrolysis product 3,5,6-trichloro-2-pyridinol using a novel bacterium Ochrobactrum sp. JAS2: A proposal of its metabolic pathway.

    Science.gov (United States)

    Abraham, Jayanthi; Silambarasan, Sivagnanam

    2016-01-01

    Biodegradation of chlorpyrifos and its major metabolite 3,5,6-trichloro-2-pyridinol (TCP) were studied with a novel bacterial strain JAS2 isolated from paddy rhizosphere soil. The molecular characterization based on 16S rRNA gene sequence homology confirmed its identity as Ochrobactrum sp. JAS2. The JAS2 strain degraded 300mgl(-1) of chlorpyrifos within 12h of incubation in the aqueous medium and it produced the TCP metabolite. However, after 72h of incubation TCP was also completely degraded by the JAS2 strain. A tentative degradation pathway of chlorpyrifos by Ochrobactrum sp. JAS2 has been proposed on basis of GC-MS analysis. The complete degradation of chlorpyrifos occurred within 24h in the soil spiked with and without addition of nutrients inoculated with Ochrobactrum sp. JAS2. TCP was obtained in both the studies which was degraded completely by 96h in the soil spiked with nutrients and whereas 120h in absence of nutrients in the soil. The mpd gene which is responsible for organophosphorus hydrolase production was identified. The isolates Ochrobactrum sp. JAS2 also exhibited a time dependent increase in the amount of tricalcium phosphate solubilization in Pikovskaya's medium. Further screening of the strain JAS2 for auxiliary plant growth promoting activities revealed its remarkable capability of producing the indole acetic acid (IAA), hydrogen cyanide (HCN) and ammonia. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. Methods of reforming hydrocarbon fuels using hexaaluminate catalysts

    Science.gov (United States)

    Gardner, Todd H [Morgantown, WV; Berry, David A [Morgantown, WV; Shekhawat, Dushyant [Morgantown, WV

    2012-03-27

    A metal substituted hexaaluminate catalyst for reforming hydrocarbon fuels to synthesis gas of the general formula AB.sub.yAl.sub.12-yO.sub.19-.delta., A being selected from alkali metals, alkaline earth metals and lanthanide metals or mixtures thereof. A dopant or surface modifier selected from a transitions metal, a spinel of an oxygen-ion conductor is incorporated. The dopant may be Ca, Cs, K, La, Sr, Ba, Li, Mg, Ce, Co, Fe, Ir, Rh, Ni, Ru, Cu, Pe, Os, Pd, Cr, Mn, W, Re, Sn, Gd, V, Ti, Ag, Au, and mixtures thereof. The oxygen-ion conductor may be a perovskite selected from M'RhO.sub.3, M'PtO.sub.3, M'PdO.sub.3, M'IrO.sub.3, M'RuO.sub.3 wherein M'=Mg, Sr, Ba, La, Ca; a spinel selected from MRh.sub.2O.sub.4, MPt.sub.2O.sub.4, MPd.sub.2O.sub.4, MIr.sub.2O.sub.4, MRu.sub.2O.sub.4 wherein M=Mg, Sr, Ba, La, Ca and mixtures thereof; a florite is selected from M''O.sub.2.

  10. Calculating additional shielding requirements in diagnostics X-ray departments by computer

    International Nuclear Information System (INIS)

    Rahimi, A.

    2004-01-01

    This report provides an extension of an existing method for the calculation of the barrier thickness required to reduce the three types of radiation exposure emitted from the source, the primary, secondary and leakage radiation, to a specified weekly design limit (MPD). Since each of these three types of radiation are of different beam quality, having different shielding requirements, NCRP 49 has provided means to calculate the necessary protective barrier thickness for each type of radiation individually. Additionally, barrier requirements specified using the techniques stated at NCRP 49, show enormous variations among users. Part of the variations is due to different assumptions made regarding the use of the examined room and the characteristics of adjoining space. Many of the differences result from the difficulty of accurately relating information from the calculations to graphs and tables involved in the calculation process specified by this report. Moreover, the latest technological developments such as mammography are not addressed and attenuation data for three-phase generators, that are most widely used today, is not provided. The design of shielding barriers in diagnostic X-ray departments generally follow the ALARA principle. That means that, in practice, the exposure levels are kept 'as low as reasonably achievable', taking into account economical and technical factors. Additionally, the calculation of barrier requirements includes many uncertainties (e.g. the workload, the actual kVp used etc.). (author)

  11. Novel micropixel avalanche photodiodes (MAPD) with super high pixel density

    International Nuclear Information System (INIS)

    Anfimov, N.; Chirikov-Zorin, I.; Dovlatov, A.; Gavrishchuk, O.; Guskov, A.; Khovanskiy, N.; Krumshtein, Z.; Leitner, R.; Meshcheryakov, G.; Nagaytsev, A.; Olchevski, A.; Rezinko, T.; Sadovskiy, A.; Sadygov, Z.; Savin, I.; Tchalyshev, V.; Tyapkin, I.; Yarygin, G.; Zerrouk, F.

    2011-01-01

    In many detectors based on scintillators the photomultiplier tubes (PMTs) are used as photodetectors. At present photodiodes are finding wide application. Solid state photodetectors allow operation in strong magnetic fields that are often present in applications, e.g. some calorimeters operating near magnets, combined PET and MRT, etc. The photon detection efficiency (PDE) of photodiodes may reach values a few times higher than that of PMTs. Also, they are rigid, compact and have relatively low operating voltage. In the last few years Micropixel Avalanche PhotoDiodes (MAPD) have been developed and started to be used. The MAPD combines a lot of advantages of semiconductor photodetectors and has a high gain, which is close to that of the PMT. Yet, they have some disadvantages, and one of them is a limited dynamic range that corresponds to a total number of pixels. The novel deep microwell MAPD with high pixel density produced by the Zecotek Company partially avoids this disadvantage. In this paper characteristics of these photodetectors are presented in comparison with the PMT characteristics. The results refer to measurements of the gain, PDE, cross-talks, photon counting and applications: beam test results of two different 'Shashlyk' EM calorimeters for COMPASS (CERN) and NICA-MPD (JINR) with the MAPD readout and a possibility of using the MAPD in PET.

  12. An optical spectrum of a large isolated gas-phase PAH cation: C78H26+

    Science.gov (United States)

    Zhen, Junfeng; Mulas, Giacomo; Bonnamy, Anthony; Joblin, Christine

    2016-01-01

    A gas-phase optical spectrum of a large polycyclic aromatic hydrocarbon (PAH) cation - C78H26+- in the 410-610 nm range is presented. This large all-benzenoid PAH should be large enough to be stable with respect to photodissociation in the harsh conditions prevailing in the interstellar medium (ISM). The spectrum is obtained via multi-photon dissociation (MPD) spectroscopy of cationic C78H26 stored in the Fourier Transform Ion Cyclotron Resonance (FT-ICR) cell using the radiation from a mid-band optical parametric oscillator (OPO) laser. The experimental spectrum shows two main absorption peaks at 431 nm and 516 nm, in good agreement with a theoretical spectrum computed via time-dependent density functional theory (TD-DFT). DFT calculations indicate that the equilibrium geometry, with the absolute minimum energy, is of lowered, nonplanar C2 symmetry instead of the more symmetric planar D2h symmetry that is usually the minimum for similar PAHs of smaller size. This kind of slightly broken symmetry could produce some of the fine structure observed in some diffuse interstellar bands (DIBs). It can also favor the folding of C78H26+ fragments and ultimately the formation of fullerenes. This study opens up the possibility to identify the most promising candidates for DIBs amongst large cationic PAHs. PMID:26942230

  13. Surface Aging Effect on Tire/Pavement Noise Medium-Term Evolution in a Medium-Size City

    Directory of Open Access Journals (Sweden)

    Víctor F. Vázquez

    2018-05-01

    Full Text Available This paper presents the geo-referenced acoustical results obtained throughout the close proximity noise (CPX technique carried out on different urban sections included within the 2017 strategic noise mapping (Directive 2002/49/CE in Ciudad Real, a Spanish medium-sized city. The employed methodology quantifies the tire/pavement noise generated in the contact between the tire and the surface of the studied sections. Measurements were carried out in different research campaigns between 2008 and 2015 (medium-term evolution. They give valuable information about the pavement-aging effect on its surface characteristics. Throughout these years, the acoustic situation of these sections has worsened mainly due to surface damage and higher mean profile depth (MPD values, although the performance does not follow the same pattern in every section. The relationships between measured tire/pavement noise and theoretical environmental noise, just due to the geometric spreading of sound energy, is also studied in order to elaborate a simple rolling noise mapping and to assess the environmental noise evolution. Traffic noise plays the main role in the noise registered within the assessed sections, therefore, CPX assessment could be used by local authorities to take decisions regarding urban planning and traffic management, with the aim of reducing noise exposure from traffic.

  14. Prevalência de distúrbios psiquiátricos menores na cidade de Pelotas, RS Prevalence of minor psychiatric disorders in the City of Pelotas, RS

    Directory of Open Access Journals (Sweden)

    Juvenal Soares Dias da Costa

    2002-08-01

    Full Text Available Foi realizado um estudo transversal, de base populacional, com o objetivo de determinar a preval��ncia de distúrbios psiquiátricos menores (DPM e verificar sua associação com fatores de risco. A amostragem por conglomerados foi definida em estágios múltiplos, incluindo 1967 pessoas com idade entre 20 e 69 anos, identificadas em 40 setores censitários da zona urbana da cidade de Pelotas. As entrevistas foram realizadas nos domicílios, utilizando-se um questionário pré-codificado, contendo SRQ-20, informações socioeconômicas e demográficas, presença de doenças crônicas, utilização de serviços de saúde, consumo de álcool, hábito de tabagismo e coleta de medidas antropométricas. A presença de DPM foi definida a partir de 6 e 7 respostas positivas no SRQ-20, para homens e mulheres, respectivamente. A prevalência de DPM foi de 28,5%, com intervalo de confiança de 95% entre 26,5% e 30,5%. A prevalência foi maior nas pessoas inseridas nas classes sociais mais baixas, de menor renda, acima de 40 anos e do sexo feminino. Na análise ajustada, os distúrbios psiquiátricos menores mantiveram-se associados com hábito de tabagismo, presença de doença crônica não transmissível e freqüência de consultas médicas. Os resultados indicam que as prevalências de DPM foram semelhantes a outros estudos realizados no município e atingem principalmente as camadas sociais mais baixas. Embora não tenham sido diferentes em relação ao tipo de serviço de saúde utilizado, mostraram associação com a freqüência de utilização de assistência médica, sugerindo que esses resultados possam orientar a formação de profissionais de saúde e o planejamento das ações de saúde.The purpose of this study was to determine the prevalence of minor psychiatric disorders (MPD in the population of Pelotas, and to determine their association with risk factors. A cross-sectional, population-based survey was conducted, with a cluster

  15. Autoimmune pancreatitis: Assessment of the enhanced duct sign on multiphase contrast-enhanced computed tomography

    International Nuclear Information System (INIS)

    Kawai, Yuichi; Suzuki, Kojiro; Itoh, Shigeki; Takada, Akira; Mori, Yoshine; Naganawa, Shinji

    2012-01-01

    Purpose: To assess the usefulness of the computed tomography (CT) finding of main pancreatic duct (MPD) wall enhancement, termed the “enhanced duct sign”, for diagnosis of autoimmune pancreatitis (AIP) in comparison with diagnosis of pancreatic carcinoma and chronic pancreatitis. Materials and methods: Two radiologists independently evaluated the presence or absence of the enhanced duct sign on multiphase contrast-enhanced CT in patients with AIP (n = 55), pancreatic carcinoma (n = 50), and chronic pancreatitis (n = 50). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of AIP were calculated. In patients demonstrating the enhanced duct sign, additional findings were evaluated by consensus. Results: The enhanced duct sign was more frequently observed in patients with AIP (37/55, 67%) than in patients with pancreatic carcinoma (5/50, 10%) or chronic pancreatitis (0/50, 0%) (P < 0.05). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the finding were 0.67, 0.95, 0.85, 0.88, and 0.84, respectively. In AIP, the lumen within the enhanced duct was completely or partially invisible in 29 of 37 (78%) patients, and the enhanced duct was observed within the affected pancreatic parenchyma in 35 of 37 (95%) patients. In pancreatic carcinoma, the lumen within the enhanced duct was visible in all patients (5/5, 100%), and the enhanced duct was observed downstream of the tumor (5/5, 100%). Conclusion: The enhanced duct sign is highly specific of AIP.

  16. Profound microcephaly, primordial dwarfism with developmental brain malformations: a new syndrome.

    Science.gov (United States)

    Abdel-Salam, Ghada M H; Abdel-Hamid, Mohamed S; Saleem, Sahar N; Ahmed, Mahmoud K H; Issa, Mahmoud; Effat, Laila K; Kayed, Hisham F; Zaki, Maha S; Gaber, Khaled R

    2012-08-01

    We describe two sibs with a lethal form of profound congenital microcephaly, intrauterine and postnatal growth retardation, subtle skeletal changes, and poorly developed brain. The sibs had striking absent cranial vault with sloping of the forehead, large beaked nose, relatively large ears, and mandibular micro-retrognathia. Brain magnetic resonance imaging (MRI) revealed extremely simplified gyral pattern, large interhemispheric cyst and agenesis of corpus callosum, abnormally shaped hippocampus, and proportionately affected cerebellum and brainstem. In addition, fundus examination showed foveal hypoplasia with optic nerve atrophy. No abnormalities of the internal organs were found. This profound form of microcephaly was identified at 17 weeks gestation by ultrasound and fetal brain MRI helped in characterizing the developmental brain malformations in the second sib. Molecular analysis excluded mutations in potentially related genes such as RNU4ATAC, SLC25A19, and ASPM. These clinical and imaging findings are unlike that of any recognized severe forms of microcephaly which is believed to be a new microcephalic primordial dwarfism (MPD) with developmental brain malformations with most probably autosomal recessive inheritance based on consanguinity and similarly affected male and female sibs. Copyright © 2012 Wiley Periodicals, Inc.

  17. Cloning, expression, purification, crystallization and preliminary X-ray analysis of the 31 kDa Vibrio cholerae heat-shock protein VcHsp31

    International Nuclear Information System (INIS)

    Das, Samir; Dey, Sanjay; Roy, Trina; Sen, Udayaditya

    2011-01-01

    A heat-shock protein from V. cholerae (VcHsp31) has been cloned, expressed, purified and crystallized. Crystals of VcHsp31 belonged to a monoclinic space group and diffracted to 1.9 Å resolution. The Gram-negative bacterium Vibrio cholerae, which is responsible for the diarrhoeal disease cholera in humans, induces the expression of numerous heat-shock genes. VcHsp31 is a 31 kDa putative heat-shock protein that belongs to the DJ-1/PfpI superfamily, functioning as both a chaperone and a protease. VcHsp31 has been cloned, overexpressed and purified by Ni 2+ –NTA affinity chromatography followed by gel filtration. Crystals of VcHsp31 were grown in the presence of PEG 6000 and MPD; they belonged to space group P2 1 and diffracted to 1.9 Å resolution. Assuming the presence of six molecules in the asymmetric unit, the Matthews coefficient was estimated to be 1.97 Å 3 Da −1 , corresponding to a solvent content of 37.4%

  18. Autoimmune pancreatitis: Assessment of the enhanced duct sign on multiphase contrast-enhanced computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Kawai, Yuichi, E-mail: kawai.yuichi@a.mbox.nagoya-u.ac.jp [Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550 (Japan); Suzuki, Kojiro, E-mail: kojiro@med.nagoya-u.ac.jp [Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550 (Japan); Itoh, Shigeki, E-mail: shigeito@nagoya-1st.jrc.or.jp [Department of Diagnostic Radiology, Japan Red Cross Nagoya Daiichi Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya 453-8511 (Japan); Takada, Akira, E-mail: takadaa@med.nagoya-u.ac.jp [Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550 (Japan); Mori, Yoshine, E-mail: yoshine@med.nagoya-u.ac.jp [Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550 (Japan); Naganawa, Shinji, E-mail: naganawa@med.nagoya-u.ac.jp [Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550 (Japan)

    2012-11-15

    Purpose: To assess the usefulness of the computed tomography (CT) finding of main pancreatic duct (MPD) wall enhancement, termed the 'enhanced duct sign', for diagnosis of autoimmune pancreatitis (AIP) in comparison with diagnosis of pancreatic carcinoma and chronic pancreatitis. Materials and methods: Two radiologists independently evaluated the presence or absence of the enhanced duct sign on multiphase contrast-enhanced CT in patients with AIP (n = 55), pancreatic carcinoma (n = 50), and chronic pancreatitis (n = 50). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of AIP were calculated. In patients demonstrating the enhanced duct sign, additional findings were evaluated by consensus. Results: The enhanced duct sign was more frequently observed in patients with AIP (37/55, 67%) than in patients with pancreatic carcinoma (5/50, 10%) or chronic pancreatitis (0/50, 0%) (P < 0.05). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the finding were 0.67, 0.95, 0.85, 0.88, and 0.84, respectively. In AIP, the lumen within the enhanced duct was completely or partially invisible in 29 of 37 (78%) patients, and the enhanced duct was observed within the affected pancreatic parenchyma in 35 of 37 (95%) patients. In pancreatic carcinoma, the lumen within the enhanced duct was visible in all patients (5/5, 100%), and the enhanced duct was observed downstream of the tumor (5/5, 100%). Conclusion: The enhanced duct sign is highly specific of AIP.

  19. Rational design of intrinsically ultramicroporous polyimides containing bridgehead-substituted triptycene for highly selective and permeable gas separation membranes

    KAUST Repository

    Swaidan, Raja

    2014-08-12

    Highly ultramicroporous, solution-processable polyimides bearing 9,10-bridgehead-substituted triptycene demonstrated the highest BET surface area reported for polyimides (840 m2 g-1) and several new highs in gas selectivity and permeability for hydrogen (1630-3980 barrers, H2/CH4 ∼ 38) and air (230-630 barrers, O 2/N2 = 5.5-5.9) separations. Two new dianhydrides bearing 9,10-diethyl- and 9,10-dipropyltriptycenes indicate that the ultramicroporosity is optimized for fast polymeric sieving with the use of short, bulky isopropyl bridgeheads and methyl-substituted diamines (TrMPD, TMPD, and TMBZ) that increase intrachain rigidity. Mechanically, the triptycene-based analogue of a spirobisindane-based polyimide exhibited 50% increases in both tensile strength at break (94 MPa) and elastic modulus (2460 MPa) with corresponding 90% lower elongations at break (6%) likely due to the ability of highly entangled spiro-based chains to unwind. To guide future polyimide design, structure/property relationships are suggested between the geometry of the contortion center, the diamine and bridgehead substituent, and the mechanical, microstructural, and gas transport properties. © 2014 American Chemical Society.

  20. Instabilities in the 'on' phase of the plasma focus

    International Nuclear Information System (INIS)

    Kaeppeler, H.J.

    1990-07-01

    In the operation of large plasma focus devices, e.g. POSEIDON, there appear saturation phenomena in the neutron production when the charging energy of the condensor bank approaches its nominal value. This saturation is attributed to the action of impurities. It is assumed that there appear instabilities which are in part caused by impurities. In order to be able to answer this question, the linear dispersion relation was derived from a three-fluid theory (electrons, ions and neutrals) with the aid of the computer algebra (CA) code MACSYMA. The inversion of the 17x17 matrix (it is assumed that v a =v i and T a =T i ) and solution of the determinant was carried out on a CONVEX C 120 computer using the CA code MAPLE. The calculation of the zeros was done with a modified CPZERO program from the SLATEC library. There appear four instabilities in the rundown phase of the plasma focus, two of them gradient driven. The first two are unstable electrostatic waves with very high phase velocities, thus they do not contribute to anomalous dissipation. The third is identified as a gradient driven space charge instability which may possibly lead to current chopping. The electron acoustic wave instability, here gradient driven, is the fourth. It was found in a previous study of MPD thruster instabilities. (orig.)

  1. Successful resection of pancreatic head cancer in a patient with circumportal pancreas: a case report with technical consideration

    Directory of Open Access Journals (Sweden)

    Kawamoto Hiroshi

    2017-03-01

    Full Text Available We report a case of pancreaticoduodenectomy for pancreatic head cancer with circumportal pancreas (CP. A 76-year-old woman was referred to our hospital with complaint of generalized pruritus. Dynamic computed tomography (CT revealed an unenhanced mass at the head of the pancreas and a dilated main pancreatic duct (MPD behind the superior mesenteric vein (SMV. She was diagnosed with pancreatic head cancer with CP and underwent subtotal stomach-preserving pancreaticoduodenectomy (SSpPD. The pancreas was transected both beneath and above the SMV, and the dominant dorsal edge of the pancreas was mobilized and anastomosed with the gut, whereas the ventral edge was closed by suture and attached to the gut. The postoperative course was uneventful without the occurrence of pancreatic fistula or bleeding. CP is a rare anomaly in which a portal vein (PV is encircled by the annular pancreatic parenchyma. CP is usually asymptomatic without any significant comorbidity but may become a surgical hazard when pancreaticoduodenectomy is performed. We report our successfully treated case, with special references to the technical approach for pancreatic anastomosis.

  2. Purification, crystallization and preliminary X-ray analysis of OsAREB8 from rice, a member of the AREB/ABF family of bZIP transcription factors, in complex with its cognate DNA

    International Nuclear Information System (INIS)

    Miyazono, Ken-ichi; Koura, Tsubasa; Kubota, Keiko; Yoshida, Takuya; Fujita, Yasunari; Yamaguchi-Shinozaki, Kazuko; Tanokura, Masaru

    2012-01-01

    OsAREB8 from rice (O. sativa), a member of the AREB/ABF family of bZIP transcription factors, was expressed, purified and crystallized using the sitting-drop vapour-diffusion method. A crystal of OsAREB8 in complex with its cognate DNA diffracted X-rays to 3.65 Å resolution. The AREB/ABF family of bZIP transcription factors play a key role in drought stress response and tolerance during the vegetative stage in plants. To reveal the DNA-recognition mechanism of the AREB/ABF family of proteins, the bZIP domain of OsAREB8, an AREB/ABF-family protein from Oryza sativa, was expressed in Escherichia coli, purified and crystallized with its cognate DNA. Crystals of the OsAREB8–DNA complex were obtained by the sitting-drop vapour-diffusion method at 277 K with a reservoir solution consisting of 50 mM MES pH 6.4, 29% MPD, 2 mM spermidine, 20 mM magnesium acetate and 100 mM sodium chloride. A crystal diffracted X-rays to 3.65 Å resolution and belonged to space group C222, with unit-cell parameters a = 155.1, b = 206.7, c = 38.5 Å. The crystal contained one OsAREB8–DNA complex in the asymmetric unit

  3. Three stages of the NICA accelerator complex

    Energy Technology Data Exchange (ETDEWEB)

    Kekelidze, V.D.; Lednicky, R. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Matveev, V.A.; Sorin, A.S. [Joint Institute for Nuclear Research, Dubna (Russian Federation); National Research Nuclear University (MEPhI), Moscow (Russian Federation); Meshkov, I.N.; Trubnikov, G.V. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Sankt-Petersburg State University, Sankt-Petersburg (Russian Federation)

    2016-08-15

    The Nuclotron-based Ion Collider fAcility (NICA) project is under development at JINR (Dubna). The general goals of the project are to provide colliding beams for experimental studies of both hot and dense strongly interacting baryonic matter and spin physics (in collisions of polarized protons and deuterons). The first program will require the running of heavy-ion mode in the energy range of √(s{sub NN}) = 4-11 GeV at luminosities up to L = 1 . 10{sup 27} cm{sup -2} s{sup -1} for {sup 197}Au{sup 79} nuclei (see details in sect. 4). This stage of the project will be preceded by fixed target experiments with the heavy-ion beam to be extracted from the Nuclotron at kinetic energies up to 4.5 GeV/u. The polarized beam mode is proposed to be used in the energy range of √(s{sub NN}) = 12-27 GeV (protons) at luminosities up to 1 . 10{sup 32} cm{sup -2} s{sup -1}. This report contains a brief description of the facility scheme and characteristics in the heavy-ion operation mode, the description of the MultiPurpose Detector (MPD), and characteristics of the reactions of the colliding ions, which will allow us to detect the mixed phase formation. The plans and status of the project development are presented. (orig.)

  4. Status of the NICA project at JINR

    Directory of Open Access Journals (Sweden)

    Kekelidze Vladimir

    2017-01-01

    Full Text Available The NICA (Nuclotron-based Ion Collider fAcility project is now under active realization at the Joint Institute for Nuclear Research (JINR, Dubna. The main goal of the project is a study of hot and dense strongly interacting matter in heavy-ion (up to Au collisions at the center-of-mass energies up to 11 GeV per nucleon. Two modes of operation are foreseen, collider mode and extracted beams, with two detectors: MPD and BM@N. The both experiments are in preparation stage. An average luminosity in the collider mode is expected to be 1027 cm−2 s−1 for Au (79+. Extracted beams of various nuclei with maximum momenta of 13 GeV/c (for protons will be available. A study of spin physics with extracted and colliding beams of polarized deuterons and protons at energies up to 27 GeV (for protons is foreseen with the NICA facility. The proposed program allows one to search for possible signs of phase transitions and critical phenomena as well as to shed light on the problem of the nucleon spin structure.

  5. Deterioration trends of asphalt pavement friction and roughness from medium-term surveys on major Italian roads

    Directory of Open Access Journals (Sweden)

    Alberti Susanna

    2017-09-01

    Full Text Available Deterioration models are the key factor for effective Pavement Management Systems, helping out road agencies to assess the actual pavement condition and forecast future performance of the asset. Among pavement condition characteristics, friction should be taken into account due to its important effect on user safety, while roughness could be used to express user comfort. The purpose of this study was to provide a reasonable case study for future improvements of Italian road management, even if the length of the analyzed highways was not intended to be representative of the overall Italian network.This research studied the friction trend (Side Force Coefficient depending on traffic levels (ESALs and pavement aging for Italian highways, combining the data with roughness and macrotexture. Surface characteristics were monitored during a seven-year time span. A selection of different road sections with homogeneous traffic levels, similar environmental conditions and surface material was performed and high-speed/high-quality road surveys were used for distress data collection. Pavement deterioration models for Italian road sectors were developed at project level, as starting point to advance pavement management practices in Italy. Degradation curves showed the same trends for similar pavement structures, materials and traffic levels; on the other hand, differences in pavement characteristics, increased ESALs and various maintenance treatments significantly altered those trends. Keywords: Pavement Management System, Deterioration models, Friction, Roughness, MPD, High-speed monitoring

  6. Oncogenes in myeloproliferative disorders.

    Science.gov (United States)

    Tefferi, Ayalew; Gilliland, D Gary

    2007-03-01

    Myeloproliferative disorders (MPDs) constitute a group of hematopoietic malignancies that feature enhanced proliferation and survival of one or more myeloid lineage cells. William Dameshek is credited for introducing the term "MPDs" in 1951 when he used it to group chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) under one clinicopathologic category. Since then, other myeloid neoplasms have been added to the MPD member list: chronic neutrophilic (CNL), eosinophilic (CEL) and myelomonocytic (CMML) leukemias; juvenile myelomonocytic leukemia (JMML); hypereosinophilic syndrome (HES); systemic mastocytosis (SM); and others. Collectively, MPDs are stem cell-derived clonal proliferative diseases whose shared and diverse phenotypic characteristics can be attributed to dysregulated signal transduction--a consequence of acquired somatic mutations. The most recognized among the latter is BCR-ABL, the disease-causing mutation in CML. Other mutations of putative pathogenetic relevance in MPDs include: JAK2V617F in PV, ET, and PMF; JAK2 exon 12 mutations in PV; MPLW515L/K in PMF and ET; KITD816V in SM; FIP1L1-PDGFRA in CEL-SM; rearrangements of PDGFRB in CEL-CMML and FGFR1 in stem cell leukemia-lymphoma syndrome; and RAS/PTPN11/NF1 mutations in JMML. This increasing repertoire of mutant molecules has streamlined translational research and molecularly targeted drug development in MPDs.

  7. Extending Jak2V617F and MplW515 mutation analysis to single hematopoietic colonies and B and T lymphocytes.

    Science.gov (United States)

    Pardanani, Animesh; Lasho, Terra L; Finke, Christy; Mesa, Ruben A; Hogan, William J; Ketterling, Rhett P; Gilliland, Dwight Gary; Tefferi, Ayalew

    2007-09-01

    JAK2V617F and MPLW515L/K are myeloproliferative disorder (MPD)-associated mutations. We genotyped 552 individual hematopoietic colonies obtained by CD34+ cell culture from 16 affected patients (13 JAK2V617F and 3 MPLW515L/K) to determine (a) the proportion of colonies harboring a particular mutation in the presence or absence of cytokines, (b) the lineage distribution of endogenous colonies for each mutation, and (c) the differences (if any) in the pattern of mutation among the various MPDs, as established by genotyping of individual colonies. Genotyping analysis revealed cohabitation of mutation-negative and mutation-positive endogenous colonies in polycythemia vera as well as other MPDs. Culture of progenitor cells harboring MPLW515L/K yielded virtually no endogenous erythroid colonies in contrast to JAK2V617F-harboring progenitor cells. The mutation pattern (i.e., relative distribution of homozygous, heterozygous, or wild-type colonies) was not a distinguishing feature among the MPDs, and MPLW515 mutations were detected in B and/or T lymphocytes in all three patients tested. These observations suggest that clonal myelopoiesis antedates acquisition of JAK2V617F or MPLW515L/K mutations and that the latter is acquired in a lympho-myeloid progenitor cell.

  8. Navigating the evolving paradigms in the diagnosis and treatment of myeloproliferative disorders.

    Science.gov (United States)

    Mesa, Ruben A

    2007-01-01

    The diagnosis and management of the BCR-ABL-negative myeloproliferative disorders (MPDs) of polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are at an explosive crossroads of scientific investigation and evolving paradigms since the discovery of the tyrosine kinase-activating JAK2V617F mutation in 2005. Additional discovery of relevant molecular lesions (JAK2 exon 12 mutations and c-MplW515L/K) have only further enriched our understanding of MPD pathogenesis. The improved diagnostic certainty these molecular markers provide have resulted in the modification, and simplification, of the World Health Organization (WHO) diagnostic algorithms for MPDs. Despite these scientific advances, however, the initial management of MPDs continues to rely upon a risk-based strategy to minimize the risk of vascular events with control of erythrocytosis, targeted antiplatelet therapy, and risk-based myelosuppressive therapy. No current medical therapy has altered the natural trend of the MPDs to lead to overt severe myelofibrosis or acute leukemia. Investigations into targeted therapies for MPDs are proceeding at a brisk pace with agents aimed at immunomodulation, decreasing marrow stromal reaction to the aberrant clone, DNA hypomethylation, or the inhibition of tyrosine kinases. Specific inhibition of JAK2 itself appears promising by in vitro investigations, and clinical trials with multiple agents are planned to commence enrollment in 2007. The potential impact of JAK2 inhibitors on the manifestations of the MPDs is unclear, but is awaited with great interest.

  9. Investigation of droplet nucleation in CCS relevant systems – design and testing of the expansion chamber

    Directory of Open Access Journals (Sweden)

    Čenský Miroslav

    2018-01-01

    Full Text Available A unique in-house designed experimental apparatus for investigation of nucleation of droplets in CCS relevant systems is being developed by the present team. The apparatus allows simulating various processes relevant to CCS technologies. Gaseous mixtures with CO2 are prepared in a Mixture Preparation Device (MPD based on accurate adjustment of flow rates of individual components [EPJ Web of Conferences 143, 02140 (2017]. The mixture then flows into an expansion chamber, where it undergoes a rapid adiabatic expansion. As a consequence of adiabatic cooling, the mixture becomes supersaturated and nucleation and simultaneous growth of droplets occurs. In this study, we describe the design and testing of the expansion part of the experimental setup. The rapid expansion was realized using two valve systems, one for low pressures (up to 0.7 MPa and the other for high pressures (up to 10 MPa. A challenge for a proper design of the expansion system is avoiding acoustic oscillations. These can occur either in the mode of Helmholtz resonator, where the compressible gas in the chamber acts as a spring and the rapidly moving gas in the valve system as a mass, or in the “flute” mode, where acoustic waves are generated in a long outlet tubing.

  10. Investigation of droplet nucleation in CCS relevant systems - design and testing of the expansion chamber

    Science.gov (United States)

    Čenský, Miroslav; Hrubý, Jan; Vinš, Václav; Hykl, Jiří; Šmíd, Bohuslav

    2018-06-01

    A unique in-house designed experimental apparatus for investigation of nucleation of droplets in CCS relevant systems is being developed by the present team. The apparatus allows simulating various processes relevant to CCS technologies. Gaseous mixtures with CO2 are prepared in a Mixture Preparation Device (MPD) based on accurate adjustment of flow rates of individual components [EPJ Web of Conferences 143, 02140 (2017)]. The mixture then flows into an expansion chamber, where it undergoes a rapid adiabatic expansion. As a consequence of adiabatic cooling, the mixture becomes supersaturated and nucleation and simultaneous growth of droplets occurs. In this study, we describe the design and testing of the expansion part of the experimental setup. The rapid expansion was realized using two valve systems, one for low pressures (up to 0.7 MPa) and the other for high pressures (up to 10 MPa). A challenge for a proper design of the expansion system is avoiding acoustic oscillations. These can occur either in the mode of Helmholtz resonator, where the compressible gas in the chamber acts as a spring and the rapidly moving gas in the valve system as a mass, or in the "flute" mode, where acoustic waves are generated in a long outlet tubing.

  11. A neutron multiplicity analysis method for uranium samples with liquid scintillators

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Hao, E-mail: zhouhao_ciae@126.com [China Institute of Atomic Energy, P.O.BOX 275-8, Beijing 102413 (China); Lin, Hongtao [Xi' an Reasearch Institute of High-tech, Xi' an, Shaanxi 710025 (China); Liu, Guorong; Li, Jinghuai; Liang, Qinglei; Zhao, Yonggang [China Institute of Atomic Energy, P.O.BOX 275-8, Beijing 102413 (China)

    2015-10-11

    A new neutron multiplicity analysis method for uranium samples with liquid scintillators is introduced. An active well-type fast neutron multiplicity counter has been built, which consists of four BC501A liquid scintillators, a n/γdiscrimination module MPD-4, a multi-stop time to digital convertor MCS6A, and two Am–Li sources. A mathematical model is built to symbolize the detection processes of fission neutrons. Based on this model, equations in the form of R=F*P*Q*T could be achieved, where F indicates the induced fission rate by interrogation sources, P indicates the transfer matrix determined by multiplication process, Q indicates the transfer matrix determined by detection efficiency, T indicates the transfer matrix determined by signal recording process and crosstalk in the counter. Unknown parameters about the item are determined by the solutions of the equations. A {sup 252}Cf source and some low enriched uranium items have been measured. The feasibility of the method is proven by its application to the data analysis of the experiments.

  12. Performance enhancement using power beaming for electric propulsion earth orbital transporters

    International Nuclear Information System (INIS)

    Dagle, J.E.

    1991-01-01

    An electric propulsion Earth orbital transport vehicle (EOTV) can effectively deliver large payloads using much less propellant than chemical transfer methods. By using an EOTV instead of a chemical upper stage, either a smaller launch vehicle can be used for the same satellite mass or a larger satellite can be deployed using the same launch vehicle. However, the propellant mass savings from using the higher specific impulse of electric propulsion may not be enough to overcome the disadvantage of the added mass and cost of the electric propulsion power source. Power system limitations have been a major factor delaying the acceptance and use of electric propulsion. This paper outlines the power requirements of electric propulsion technology being developed today, including arcjets, magnetoplasmadynamic (MPD) thrusters, and ion engines. Power supply characteristics are discussed for nuclear, solar, and power-beaming systems. Operational characteristics are given for each, as are the impacts of the power supply alternative on the overall craft performance. Because of its modular nature, the power-beaming approach is able to meet the power requirements of all three electric propulsion types. Also, commonality of approach allows different electric propulsion approaches to be powered by a single power supply approach. Power beaming exhibits better flexibility and performance than on-board nuclear or solar power systems

  13. TAU: a design for a thousand astronomical unit voyage

    International Nuclear Information System (INIS)

    Eubanks, D.; Alvis, J.; Bechler, E.; Lyon, W. III; McFarlane, D.; Palmrose, D.; Schmitz, P.

    1987-01-01

    The Jet Propulsion Lab. (JPL) has proposed a deep-space probe to travel to a distance of one thousand astronomical units -25 times further from the Sun than Pluto. In order to achieve this goal within the lifetime of the investigators, the mission time is set at a maximum of 50 yr. The JPL proposal postulates a design in which the probe is under powered thrust for the first 10 yr of the mission and coasts for the next 40 yr. A continuous high specific impulse, Isp (the ratio of thrust to propellant mass flow rate), low thrust propulsion system (either magnetoplasmadynamic (MPD) or ion thrusters) is required in order to achieve this goal. This in turn necessitates electrical power in the megawatt range. The only power source that is practical for this situation is a nuclear reactor. It was a this point that the Nuclear Engineering Dept. at Texas A and M Univ. began its ongoing work, looking into several areas of the proposal in which a more detailed description was needed. These areas of interest were power, propulsion, heavy lift launch capabilities, and trajectory analysis. In addition to all of the boundaries previously outlined, the technology level is assumed to be that of 1995, 8 yr from now

  14. Comparison of Growth Kinetics of Various Pathogenic E. coli on Fresh Perilla Leaf

    Directory of Open Access Journals (Sweden)

    Juhui Kim

    2013-08-01

    Full Text Available Growth kinetics for Escherichia coli O157:H7 in perilla leaves were compared to those of pathogenic E. coli strains, including enteropathogenic (EPEC, enterotoxigenic (ETEC, enteroinvasive (EIEC and other enterohemorrhagic (EHEC at 13, 17, 24, 30 and 36 °C. Models for lag time (LT, specific growth rate (SGR and maximum population density (MPD as a function of temperature were developed. The performance of the models was quantified using the ratio method and an acceptable prediction zone method. Significant differences in SGR and LT among the strains were observed at all temperatures. Overall, the shortest LT was observed with E. coli O157:H7, followed by EPEC, other EHEC, EIEC and ETEC, while the fastest growth rates were noted in EPEC, followed by E. coli O157:H7, ETEC, other EHEC and EIEC. The models for E. coli O157:H7 in perilla leaves was suitable for use in making predictions for EPEC and other EHEC strains.

  15. JAK2 V617F, MPL W515L and JAK2 Exon 12 Mutations in Chinese Patients with Primary Myelofibrosis.

    Science.gov (United States)

    Xia, Jun; Lu, Mi-Ze; Jiang, Yuan-Qiang; Yang, Guo-Hua; Zhuang, Yun; Sun, Hong-Li; Shen, Yun-Feng

    2012-03-01

    JAK2 V617F, MPL W515L and JAK2 exon 12 mutations are novel acquired mutations that induce constitutive cytokine-independent activation of the JAK-STAT pathway in myeloproliferative disorders (MPD). The discovery of these mutations provides novel mechanism for activation of signal transduction in hematopoietic malignancies. This research was to investigate their prevalence in Chinese patients with primary myelofibrosis (PMF). We introduced allele-specific PCR (AS-PCR) combined with sequence analysis to simultaneously screen JAK2 V617F, MPL W515L and JAK2 exon 12 mutations in 30 patients with PMF. Fifteen PMF patients (50.0%) carried JAK2 V617F mutation, and only two JAK2 V617F-negative patients (6.7%) harbored MPL W515L mutation. None had JAK2 exon 12 mutations. Furthermore, these three mutations were not detected in 50 healthy controls. MPL W515L and JAK2 V617F mutations existed in PMF patients but JAK2 exon 12 mutations not. JAK2 V617F and MPL W515L and mutations might contribute to the primary molecular pathogenesis in patients with PMF.

  16. High-Performance Thin-Film-Nanocomposite Cation Exchange Membranes Containing Hydrophobic Zeolitic Imidazolate Framework for Monovalent Selectivity

    Directory of Open Access Journals (Sweden)

    Jian Li

    2018-05-01

    Full Text Available Zeolitic imidazolate framework-8 (ZIF-8 offers good hydrothermal, chemical, and thermal stabilities, and is therefore of interest in membrane synthesis. In this work, an interfacial polymerization (IP method was applied by anchoring ZIF-8 to the skin layer of thin-film nanocomposite (TFN membranes in order to obtain monovalent selectivity in electrodialysis. Organic trimesoyl chloride (TMC, 0.1 wt % solutions and aqueous m-phenyl diamine (MPD, 2% w/v solutions were used during the interfacial polymerization process. A range of polyamine (PA/ZIF-8 based membranes was fabricated by varying the concentration of ZIF-8 in the organic solution. The properties of the primary and modified membrane were characterized by scanning electron microscope (SEM, energy dispersive X-ray analysis (EDAX, atomic force microscopy (AFM, water uptake, ion exchange capacity, and contact angle measurements. No significant changes of the surface structure of the PA/ZIF-8 based membranes were observed. Nevertheless, the presence of ZIF-8 under the PA layer plays a key role in the separation process. For single salt solutions that were applied in electrodialysis (ED, faster transport of Na+ and Mg2+ was obtained after introducing the ZIF-8 nanoparticles, however, the desalination efficiency remained constant. When the hybrid membranes were applied to electrodialysis for binary mixtures containing Na+ as well as Mg2+, it was demonstrated that the monovalent selectivity and Na+ flux were enhanced by a higher ZIF-8 loading.

  17. Far-infrared spectra of yttrium-doped gold clusters Au(n)Y (n=1-9).

    Science.gov (United States)

    Lin, Ling; Claes, Pieterjan; Gruene, Philipp; Meijer, Gerard; Fielicke, André; Nguyen, Minh Tho; Lievens, Peter

    2010-06-21

    The geometric, spectroscopic, and electronic properties of neutral yttrium-doped gold clusters Au(n)Y (n=1-9) are studied by far-infrared multiple photon dissociation (FIR-MPD) spectroscopy and quantum chemical calculations. Comparison of the observed and calculated vibrational spectra allows the structures of the isomers present in the molecular beam to be determined. Most of the isomers for which the IR spectra agree best with experiment are calculated to be the energetically most stable ones. Attachment of xenon to the Au(n)Y cluster can cause changes in the IR spectra, which involve band shifts and band splittings. In some cases symmetry changes, as a result of the attachment of xenon atoms, were also observed. All the Au(n)Y clusters considered prefer a low spin state. In contrast to pure gold clusters, which exhibit exclusively planar lowest-energy structures for small sizes, several of the studied species are three-dimensional. This is particularly the case for Au(4)Y and Au(9)Y, while for some other sizes (n=5, 8) the 3D structures have an energy similar to that of their 2D counterparts. Several of the lowest-energy structures are quasi-2D, that is, slightly distorted from planar shapes. For all the studied species the Y atom prefers high coordination, which is different from other metal dopants in gold clusters.

  18. Polysulfone thin film composite nanofiltration membranes for removal of textile dyes wastewater

    Science.gov (United States)

    Sutedja, Andrew; Aileen Josephine, Claresta; Mangindaan, Dave

    2017-12-01

    This research was conducted to produce nanofiltration (NF) membranes, which have good performance in terms of removal of textile dye (Reactive Red 120, RR120) from simulated wastewater as one of several eco-engineering developments for sustainable water resource management. Phase inversion technique was utilized to fabricate the membrane with polysulfone (PSF) support, dissolved in N-methyl-2 pyrollidone (NMP) solvent, and diethylene glycol (DEG) as non-solvent additive. The fabricated membrane then modified with the additional of dopamine coating and further modified by interfacial polymerization (IP) to form a thin film composite (TFC)-NF membrane with PSF substrate. TFC was formed from interaction between amine monomer (2 %-weight of m-phenylenediamine (MPD) in deionized water) and acyl chloride (0.2 %-weight of trimesoyl chloride (TMC) in hexane). From this study, the fabricated PSF-TFC membrane could remove dyestuff from RR120 wastewater by 88% rejection at 120 psi. The result of this study is promising to be applied in Indonesia where researches on removal of dyes from textile wastewater by using membranes are still quite rare. Therefore, this paper may open new avenues for development of eco-engineering development in Indonesia.

  19. Identification and characterization of bacteria in a selenium-contaminated hypersaline evaporation pond.

    Science.gov (United States)

    de Souza, M P; Amini, A; Dojka, M A; Pickering, I J; Dawson, S C; Pace, N R; Terry , N

    2001-09-01

    Solar evaporation ponds are commonly used to reduce the volume of seleniferous agricultural drainage water in the San Joaquin Valley, Calif. These hypersaline ponds pose an environmental health hazard because they are heavily contaminated with selenium (Se), mainly in the form of selenate. Se in the ponds may be removed by microbial Se volatilization, a bioremediation process whereby toxic, bioavailable selenate is converted to relatively nontoxic dimethylselenide gas. In order to identify microbes that may be used for Se bioremediation, a 16S ribosomal DNA phylogenetic analysis of an aerobic hypersaline pond in the San Joaquin Valley showed that a previously unaffiliated group of uncultured bacteria (belonging to the order Cytophagales) was dominant, followed by a group of cultured gamma-Proteobacteria which was closely related to Halomonas species. Se K-edge X-ray absorption spectroscopy of selenate-treated bacterial isolates showed that they accumulated a mixture of predominantly selenate and a selenomethionine-like species, consistent with the idea that selenate was assimilated via the S assimilation pathway. One of these bacterial isolates (Halomonas-like strain MPD-51) was the best candidate for the bioremediation of hypersaline evaporation ponds contaminated with high Se concentrations because it tolerated 2 M selenate and 32.5% NaCl, grew rapidly in media containing selenate, and accumulated and volatilized Se at high rates (1.65 microg of Se g of protein(-1) x h(-1)), compared to other cultured bacterial isolates.

  20. Effect of CO{sub 2}-laser irradiation on properties and performance of thin-film composite polyamide reverse osmosis membrane

    Energy Technology Data Exchange (ETDEWEB)

    Jahangiri, Foad; Mousavi, Seyyed Abbas; Farhadi, Fathollah; Sabzi, Behnam; Chenari, Zeinab [Sharif University of Technology, Tehran (Iran, Islamic Republic of); Vatanpour, Vahid [Kharazmi (Tarbiat Moallem) University, Tehran (Iran, Islamic Republic of)

    2016-03-15

    CO{sub 2}-laser irradiation was used to modify the surface properties of thin-film composite (TFC) polyamide reverse osmosis (RO) membranes. These membranes were first synthesized via interfacial polymerization of m-phenylenediamine (MPD) monomers and trimesoyl chloride (TMC) over porous polysulfone ultrafiltration support, followed by a CO{sub 2}-irradiation. AFM, ATR-FTIR, SEM and contact angle measurements were used to characterize the surface properties of these membranes. The ATR-FTIR results indicated that CO{sub 2}-laser irradiation did not induce any functional groups on the membrane surface. However, it was found that the laser irradiation enhanced the NaCl salt rejection and slightly reduced the permeate flux. Moreover, the maintenance of the flux in modified membranes was much higher than untreated ones. Specially, after 180 min of filtration, the reduction in initial flux for the unmodified membranes was 22%. However, the reduction in initial flux for the modified membranes was less than 5%. Bovine serum albumin (BSA) filtration revealed an improvement in the antifouling properties of the modified membranes. The changes in the membrane surface morphology showed that the roughness of membrane surface is reduced significantly.

  1. Microstructural evolution during transient liquid phase bonding of Inconel 617 using Ni-Si-B filler metal

    Energy Technology Data Exchange (ETDEWEB)

    Jalilian, F. [McGill University, Department of Mining, Metals and Materials Engineering, 3610 University St., M.H. Wong Building, Montreal Que., H3A 2B2 (Canada); Jahazi, M. [Aerospace Manufacturing Technology Center, National Research Council of Canada (Canada); Drew, R.A.L. [McGill University, Department of Mining, Metals and Materials Engineering, 3610 University St., M.H. Wong Building, Montreal Que., H3A 2B2 (Canada)]. E-mail: robin.drew@mcgill.ca

    2006-05-15

    The influence of process parameters on microstructural characteristics of transient liquid phase (TLP) bonded Inconel 617 alloy was investigated. Experiments were carried out at 1065 deg. C using nickel based filler metal (Ni-4.5% Si-3% B) with B as the melting point depressant (MPD) element. Two different thickness of interlayer and various holding times were employed. The influence of these processing parameters on the characteristics of the joint area particularly size, morphology and composition of precipitates was investigated. The presence of MoB, Mo{sub 2}B, M{sub 23}C{sub 6}, TiC, M{sub 23}(B, C){sub 6} and Ni{sub 3}B precipitates in the diffusion layer and Ni{sub 3}B, Ni{sub 3}Si and Ni{sub 5}Si{sub 2} precipitates in the interlayer at the interface between the base metal and interlayer were demonstrated using electron back scattered diffraction (EBSD), energy dispersive spectrometry (EDS) and TEM.

  2. MEKANISME SEGMENTASI LAJU BIT PADA DYNAMIC ADAPTIVE STREAMING OVER HTTP (DASH UNTUK APLIKASI VIDEO STREAMING

    Directory of Open Access Journals (Sweden)

    Muhammad Audy Bazly

    2015-12-01

    Full Text Available This paper aims to analyze Internet-based streaming video service in the communication media with variable bit rates. The proposed scheme on Dynamic Adaptive Streaming over HTTP (DASH using the internet network that adapts to the protocol Hyper Text Transfer Protocol (HTTP. DASH technology allows a video in the video segmentation into several packages that will distreamingkan. DASH initial stage is to compress the video source to lower the bit rate video codec uses H.26. Video compressed further in the segmentation using MP4Box generates streaming packets with the specified duration. These packages are assembled into packets in a streaming media format Presentation Description (MPD or known as MPEG-DASH. Streaming video format MPEG-DASH run on a platform with the player bitdash teritegrasi bitcoin. With this scheme, the video will have several variants of the bit rates that gave rise to the concept of scalability of streaming video services on the client side. The main target of the mechanism is smooth the MPEG-DASH streaming video display on the client. The simulation results show that the scheme based scalable video streaming MPEG- DASH able to improve the quality of image display on the client side, where the procedure bufering videos can be made constant and fine for the duration of video views

  3. ADAPTIVE STREAMING OVER HTTP (DASH UNTUK APLIKASI VIDEO STREAMING

    Directory of Open Access Journals (Sweden)

    I Made Oka Widyantara

    2015-12-01

    Full Text Available This paper aims to analyze Internet-based streaming video service in the communication media with variable bit rates. The proposed scheme on Dynamic Adaptive Streaming over HTTP (DASH using the internet network that adapts to the protocol Hyper Text Transfer Protocol (HTTP. DASH technology allows a video in the video segmentation into several packages that will distreamingkan. DASH initial stage is to compress the video source to lower the bit rate video codec uses H.26. Video compressed further in the segmentation using MP4Box generates streaming packets with the specified duration. These packages are assembled into packets in a streaming media format Presentation Description (MPD or known as MPEG-DASH. Streaming video format MPEG-DASH run on a platform with the player bitdash teritegrasi bitcoin. With this scheme, the video will have several variants of the bit rates that gave rise to the concept of scalability of streaming video services on the client side. The main target of the mechanism is smooth the MPEG-DASH streaming video display on the client. The simulation results show that the scheme based scalable video streaming MPEG-DASH able to improve the quality of image display on the client side, where the procedure bufering videos can be made constant and fine for the duration of video views

  4. Big Data-Based Approach to Detect, Locate, and Enhance the Stability of an Unplanned Microgrid Islanding

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Huaiguang; Li, Yan; Zhang, Yingchen; Zhang, Jun Jason; Gao, David Wenzhong; Muljadi, Eduard; Gu, Yi

    2017-10-01

    In this paper, a big data-based approach is proposed for the security improvement of an unplanned microgrid islanding (UMI). The proposed approach contains two major steps: the first step is big data analysis of wide-area monitoring to detect a UMI and locate it; the second step is particle swarm optimization (PSO)-based stability enhancement for the UMI. First, an optimal synchrophasor measurement device selection (OSMDS) and matching pursuit decomposition (MPD)-based spatial-temporal analysis approach is proposed to significantly reduce the volume of data while keeping appropriate information from the synchrophasor measurements. Second, a random forest-based ensemble learning approach is trained to detect the UMI. When combined with grid topology, the UMI can be located. Then the stability problem of the UMI is formulated as an optimization problem and the PSO is used to find the optimal operational parameters of the UMI. An eigenvalue-based multiobjective function is proposed, which aims to improve the damping and dynamic characteristics of the UMI. Finally, the simulation results demonstrate the effectiveness and robustness of the proposed approach.

  5. IR laser enrichment of light elements isotopes - challenges and prospects

    International Nuclear Information System (INIS)

    Parthasarathy, V.

    2002-01-01

    Full text: Infra-red multiple photon dissociation (IR MPD) of poly-atomic molecules has made considerable progress since its discovery in the early seventies. Since the process was found to be isotopically selective; the possibility of laser isotope separation (LIS) created a lot of initial excitement. While the early investigations were concerned with the fundamental dynamics and potential applications of the phenomenon, serious efforts for the isotope enrichment process have been made only during the last decade. These efforts focussed on aspects to improve both the enrichment factor and throughput in various systems. Many research groups have achieved a good measure of success for scaling up the process for various light elements like carbon, oxygen, silicon and sulphur whose isotopes are quite important in medicine and technology. Significant results have been reported especially for the separation of carbon isotopes wherein macroscopic operating scales have been already realised. This talk will give-a summary of our work carried out at BARC and highlight the current efforts for scaling up the process for carbon isotopes enrichment. This would include the design aspects of a large photochemical reactor with multi-pass, refocusing optics for efficient photon utilization. It will also cover the development of a cryogenic distillation set up and a preparative gas chromatograph for a large scale separation and collection of the isotopically enriched photoproduct in the post irradiation stage. Based on the experience gained and infra structure developed, plans are afoot to separate oxygen and sulphur isotopes using a similar approach

  6. Frequency of JAK2 V617F mutation in patients with Philadelphia positive Chronic Myeloid Leukemia in Pakistan.

    Science.gov (United States)

    Tabassum, Najia; Saboor, Mohammed; Ghani, Rubina; Moinuddin, Moinuddin

    2014-01-01

    Co-existence of myeloproliferative disorders (MPD) and Janus associated kinase 2 mutation (JAK2 V617F) is a well-established fact. Only few case reports are available showing presence of JAK2 V617F mutation in chronic myeloid leukemia (CML). Purpose of this study was to determine the frequency of JAK2 V617F mutation in Philadelphia Chromosome positive (Ph (+)) CML patients in Pakistan. The study was conducted from August 2009 to July 2010 at Civil Hospital and Baqai Institute of Hematology (BIH) Karachi. Blood samples from 25 patients with CML were collected. Multiplex reverse transcription polymerase chain reaction (RT-PCR) was performed for Breakpoint Cluster Region - Abelson (BCR-ABL) rearrangement. Conventional PCR was performed for JAK2 V617F mutation on BCR-ABL positive samples. All 25 samples showed BCR-ABL rearrangement. Out of these 11 samples (44%) had JAK2 V617F mutation; the remaining 14 (56%) cases showed JAK2 617V wild type. It is concluded that the co-existence of Ph (+)CML and JAK2 V617F mutation is possible.

  7. A new integrated micro-macro approach to damage and fracture of composites

    Energy Technology Data Exchange (ETDEWEB)

    Tay, Tong-Earn [Department of Mechanical Engineering, National University of Singapore (NUS), 9 Engineering Drive 1, Singapore 119260 (Singapore)]. E-mail: mpetayte@nus.edu.sg; Tan, Vincent B.C. [Department of Mechanical Engineering, National University of Singapore (NUS), 9 Engineering Drive 1, Singapore 119260 (Singapore); Liu, Guangyan [Department of Mechanical Engineering, National University of Singapore (NUS), 9 Engineering Drive 1, Singapore 119260 (Singapore)

    2006-07-25

    The element-failure method (EFM) is a novel finite element-based method for the modeling of damage, fracture and delamination in fibre-reinforced composite laminates. The nature of damage in composite laminates is generally diffused and complex, characterized by multiple matrix cracks, fibre pullout, fibre breakage and delaminations. It is usually not possible to model or identify crack tips in the conventional fashion of fracture mechanics. The central idea of the EFM, on the other hand, is to model the damaged portions with partially failed elements, whose nodal forces have been modified to take into account the local damage modes. This has the additional benefit of unconditional computational stability compared to other methods such as material property degradation (MPD) models. Here, we present the application of EFM with a recently-proposed failure criterion called the strain invariant failure theory (SIFT) in the prediction of complex damage progression in open-hole tension (OHT) composite laminates, and show that the damage patterns and predicted final failure loads are in very good agreement with experiments.

  8. [External pancreatic fistulas management].

    Science.gov (United States)

    Stepan, E V; Ermolov, A S; Rogal', M L; Teterin, Yu S

    The main principles of treatment of external postoperative pancreatic fistulas are viewed in the article. Pancreatic trauma was the reason of pancreatic fistula in 38.7% of the cases, operations because of acute pancreatitis - in 25.8%, and pancreatic pseudocyst drainage - in 35.5%. 93 patients recovered after the treatment. Complex conservative treatment of EPF allowed to close fistulas in 74.2% of the patients with normal patency of the main pancreatic duct (MPD). The usage of octreotide 600-900 mcg daily for at least 5 days to decrease pancreatic secretion was an important part of the conservative treatment. Endoscopic papillotomy was performed in patients with major duodenal papilla obstruction and interruption of transporting of pancreatic secretion to duodenum. Stent of the main pancreatic duct was indicated in patients with extended pancreatic duct stenosis to normalize transport of pancreatic secretion to duodenum. Surgical formation of anastomosis between distal part of the main pancreatic duct and gastro-intestinal tract was carried out when it was impossible to fulfill endoscopic stenting of pancreatic duct either because of its interruption and diastasis between its ends, or in the cases of unsuccessful conservative treatment of external pancreatic fistula caused by drainage of pseudocyst.

  9. Crystallization and preliminary X-ray diffraction studies of the BTL2 lipase from the extremophilic microorganism Bacillus thermocatenulatus

    International Nuclear Information System (INIS)

    Carrasco-López, César; Godoy, Cesar; Rivas, Blanca de las; Fernández-Lorente, Gloria; Palomo, José M.; Guisán, José M.; Fernández-Lafuente, Roberto; Martínez-Ripoll, Martín; Hermoso, Juan A.

    2008-01-01

    BTL2, a thermostable enantioselective biocatalyst of interest for industrial applications, has been crystallized using the sitting-drop vapour-diffusion method. Preliminary X-ray data to 2.2 Å resolution allowed the determination of its unit-cell parameters and space group and initiation of its structure determination. Bacillus thermocatenulatus lipase 2 (BTL2) is a thermoalkalophilic lipase that has been reported as an enantioselective biocatalyst for diverse reactions and that heads a group of enzymes that share high resistance towards many inactivation agents (heat, organic solvents, pH etc.). This makes BTL2 an important research target because of its potential industrial applications. BTL2 was cloned and overexpressed in Escherichia coli, purified and concentrated for crystallization using the sitting-drop vapour-diffusion method at 291 K. Crystals grew from a mixture of 13% MPD and 0.2 M ammonium acetate in 0.05 M sodium citrate pH 5.5–5.6. The crystals, which belonged to the orthorhombic space group I222 with unit-cell parameters a = 73.07, b = 129.08, c = 127.49 Å, allowed the collection of an X-ray data set to 2.2 Å resolution

  10. An automated system for selective fission product separations; decays of 113-115Pd

    International Nuclear Information System (INIS)

    Meikrantz, D.H.; Gehrke, R.J.; McIsaac, L.D.; Baker, J.D.; Greenwood, R.C.

    1981-01-01

    A microcomputer controlled radiochemical separation system has been developed for the isolation and study of fission products with half-lives of approx. >= 10 s. The system is based upon solvent extraction with three centrifugal contactors coupled in series, which provides both rapid and highly efficient separations with large decontamination factors. This automated system was utilized to study the radioactive decays of 113-115 Pd via solvent extraction of the Pd-dimethylglyoxime complex from 252 Cf fission products. As a result of this effort, γ-rays associated with the decay of approx. equal to 90-s sup(113,113m)Pd, 149-s 114 Pd and 47-s 115 Pd have been identified. The isotopic assignments to each of these Pd radioactivities have been confirmed from observation of the growth and decay curves of their respective Ag daughters. In addition, previously unreported Ag γ-rays have been assigned; one to the decay of 69-s 113 Ag, and two to the decay of 19-s 115 Ag. (orig.)

  11. Classification and source determination of medium petroleum distillates by chemometric and artificial neural networks: a self organizing feature approach.

    Science.gov (United States)

    Mat-Desa, Wan N S; Ismail, Dzulkiflee; NicDaeid, Niamh

    2011-10-15

    Three different medium petroleum distillate (MPD) products (white spirit, paint brush cleaner, and lamp oil) were purchased from commercial stores in Glasgow, Scotland. Samples of 10, 25, 50, 75, 90, and 95% evaporated product were prepared, resulting in 56 samples in total which were analyzed using gas chromatography-mass spectrometry. Data sets from the chromatographic patterns were examined and preprocessed for unsupervised multivariate analyses using principal component analysis (PCA), hierarchical cluster analysis (HCA), and a self organizing feature map (SOFM) artificial neural network. It was revealed that data sets comprised of higher boiling point hydrocarbon compounds provided a good means for the classification of the samples and successfully linked highly weathered samples back to their unevaporated counterpart in every case. The classification abilities of SOFM were further tested and validated for their predictive abilities where one set of weather data in each case was withdrawn from the sample set and used as a test set of the retrained network. This revealed SOFM to be an outstanding mechanism for sample discrimination and linkage over the more conventional PCA and HCA methods often suggested for such data analysis. SOFM also has the advantage of providing additional information through the evaluation of component planes facilitating the investigation of underlying variables that account for the classification. © 2011 American Chemical Society

  12. Visibility of minute objects with low contrast

    International Nuclear Information System (INIS)

    Sato, Nobuo

    1982-01-01

    Minimum perceptible contrast was obtained with a penetrameter made of aluminum plates, in which 40 very small holes were perforated. An object can be seen when its contrast exceeds the minimum perceptible contrast. Visual threshold contrast ratio offers minimum perceptible diameter (MPD) which is theoretically obtained from an image contrast corresponding to the technique applied. The MPDs were obtained prior to experiment as a function of system speed, beam quality, exposure range and magnification, which resulted in a reasonable agreement with the experimental results. The visibility of small dot-like objects depends on the granularity as its threshold is governed by the surrounding grainy noise. However it was revealed that MTF was as important as granularity. Dot and lineshaped objects were simulated with small glass beads and nylon fibrils, respectively, in order to make ROC analysis on the different radiographic techniques with a CGR Senograph 500T mammographic unit. The 1.5X magnification technique showed the largest advantage on phantom work basis, but clinical evaluation showed the different weight of the affecting physical factors. The results of ROC analysis were extended to entropy analysis. The visibility in actual mammography depends upon the acutance of images as Xeroradiography proved. (Kako, I.)

  13. Probing the Hidden Geology of Isidis Planitia (Mars with Impact Craters

    Directory of Open Access Journals (Sweden)

    Graziella Caprarelli

    2015-02-01

    Full Text Available In this study we investigated Isidis Planitia, a 1325 km diameter multi-ring impact basin intersecting the Martian hemispheric dichotomy, located in the eastern hemisphere, between Syrtis Major and Utopia Planitia. From Mars Orbiter Laser Altimeter gridded data we observed that in the center of Isidis the −3700 m and −3800 m isolines strike NW-SE, being quasi-parallel to the diameter of the basin. We interpreted this as evidence that the basement of Isidis Planitia was faulted prior to being completely covered by layers of sediments and volcanic rocks. Plotting the morphometric data of impact craters located on the floor of the basin in a measured depths vs. predicted depths diagram (MPD, we concluded that the fault planes should dip SW, which is consistent with the location of the most topographically depressed sector of Isidis Planitia. We also estimated a minimum vertical displacement of ~1–2 km. Considering that the crust under Isidis Planitia is only a few km thick, our estimate implies brittle behavior of the lithosphere under the basin, suggesting that a low geothermal gradient and rheologically strong material characterize this Martian location.

  14. A new integrated micro-macro approach to damage and fracture of composites

    International Nuclear Information System (INIS)

    Tay, Tong-Earn; Tan, Vincent B.C.; Liu, Guangyan

    2006-01-01

    The element-failure method (EFM) is a novel finite element-based method for the modeling of damage, fracture and delamination in fibre-reinforced composite laminates. The nature of damage in composite laminates is generally diffused and complex, characterized by multiple matrix cracks, fibre pullout, fibre breakage and delaminations. It is usually not possible to model or identify crack tips in the conventional fashion of fracture mechanics. The central idea of the EFM, on the other hand, is to model the damaged portions with partially failed elements, whose nodal forces have been modified to take into account the local damage modes. This has the additional benefit of unconditional computational stability compared to other methods such as material property degradation (MPD) models. Here, we present the application of EFM with a recently-proposed failure criterion called the strain invariant failure theory (SIFT) in the prediction of complex damage progression in open-hole tension (OHT) composite laminates, and show that the damage patterns and predicted final failure loads are in very good agreement with experiments

  15. Novel micropixel avalanche photodiodes (MAPD) with superhigh pixel density

    International Nuclear Information System (INIS)

    Anfimov, N.; Chirikov-Zorin, I.; Dovlatov, A.

    2010-01-01

    In many detectors based on scintillators the photomultiplier tubes (PMTs) are used as photodetectors. At present photodiodes are finding wide application. Solid state photodetectors allow operation in strong magnetic fields that are often present in applications, e.g., some calorimeters operating near magnets, combined PET and MRT, etc. The photon detection efficiency (PDE) of photodiodes may reach values a few times higher than that of PMTs. Also, they are rigid, compact and have relatively low operating voltage. In the last few years Micropixel Avalanche PhotoDiodes (MAPDs) have been developed and started to be used. The MAPD combines a lot of advantages of semiconductor photodetectors and has a high gain, which is close to that of the PMT. Yet, they have some disadvantages, and one of them is a limited dynamic range that corresponds to a total number of pixels. The novel deep microwell MAPD with high pixel density produced by Zecotek Company partially avoids this disadvantage. In this paper characteristics of these photodetectors are presented in comparison with the PMT characteristics. The results refer to measurements of the gain, PDE, cross-talks, photon counting and applications: beam test results of two different 'Shashlyk' EM calorimeters for COMPASS (CERN) and NICA-MPD (JINR) with the MAPD readout and a possibility of using the MAPD in PET

  16. Spin Polarization and Quantum Spins in Au Nanoparticles

    Directory of Open Access Journals (Sweden)

    Wen-Hsien Li

    2013-08-01

    Full Text Available The present study focuses on investigating the magnetic properties and the critical particle size for developing sizable spontaneous magnetic moment of bare Au nanoparticles. Seven sets of bare Au nanoparticle assemblies, with diameters from 3.5 to 17.5 nm, were fabricated with the gas condensation method. Line profiles of the X-ray diffraction peaks were used to determine the mean particle diameters and size distributions of the nanoparticle assemblies. The magnetization curves M(Ha reveal Langevin field profiles. Magnetic hysteresis was clearly revealed in the low field regime even at 300 K. Contributions to the magnetization from different size particles in the nanoparticle assemblies were considered when analyzing the M(Ha curves. The results show that the maximum particle moment will appear in 2.4 nm Au particles. A similar result of the maximum saturation magnetization appearing in 2.3 nm Au particles is also concluded through analysis of the dependency of the saturation magnetization MP on particle size. The MP(d curve departs significantly from the 1/d dependence, but can be described by a log-normal function. Magnetization can be barely detected for Au particles larger than 27 nm. Magnetic field induced Zeeman magnetization from the quantum confined Kubo gap opening appears in Au nanoparticles smaller than 9.5 nm in diameter.

  17. Rational design of intrinsically ultramicroporous polyimides containing bridgehead-substituted triptycene for highly selective and permeable gas separation membranes

    KAUST Repository

    Swaidan, Raja; Al-Saeedi, Majed; Ghanem, Bader; Litwiller, Eric; Pinnau, Ingo

    2014-01-01

    Highly ultramicroporous, solution-processable polyimides bearing 9,10-bridgehead-substituted triptycene demonstrated the highest BET surface area reported for polyimides (840 m2 g-1) and several new highs in gas selectivity and permeability for hydrogen (1630-3980 barrers, H2/CH4 ∼ 38) and air (230-630 barrers, O 2/N2 = 5.5-5.9) separations. Two new dianhydrides bearing 9,10-diethyl- and 9,10-dipropyltriptycenes indicate that the ultramicroporosity is optimized for fast polymeric sieving with the use of short, bulky isopropyl bridgeheads and methyl-substituted diamines (TrMPD, TMPD, and TMBZ) that increase intrachain rigidity. Mechanically, the triptycene-based analogue of a spirobisindane-based polyimide exhibited 50% increases in both tensile strength at break (94 MPa) and elastic modulus (2460 MPa) with corresponding 90% lower elongations at break (6%) likely due to the ability of highly entangled spiro-based chains to unwind. To guide future polyimide design, structure/property relationships are suggested between the geometry of the contortion center, the diamine and bridgehead substituent, and the mechanical, microstructural, and gas transport properties. © 2014 American Chemical Society.

  18. Low energy methods of molecular laser isotope separation

    International Nuclear Information System (INIS)

    Makarov, G N

    2015-01-01

    Of the many proposals to date for laser-assisted isotope separation methods, isotope-selective infrared (IR) multiphoton dissociation (MPD) of molecules has been the most fully developed. This concept served as the basis for the development and operation of the carbon isotope separation facility in Kaliningrad, Russia. The extension of this method to heavy elements, including uranium, is hindered by, among other factors, the high power consumption and the lack of high-efficiency high-power laser systems. In this connection, research and development covering low energy methods for the laser separation of isotopes (including those of heavy atoms) is currently in high demand. This paper reviews approaches to the realization of IR-laser-induced isotope-selective processes, some of which are potentially the basis on which low-energy methods for molecular laser isotope separation can be developed. The basic physics and chemistry, application potential, and strengths and weaknesses of these approaches are discussed. Potentially promising alternatives to the title methods are examined. (reviews of topical problems)

  19. Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cγ at the centrosome

    Directory of Open Access Journals (Sweden)

    Tassin Anne-Marie

    2008-04-01

    Full Text Available Abstract Background The t(6;8 translocation found in rare and agressive myeloproliferative disorders results in a chimeric gene encoding the FOP-FGFR1 fusion protein. This protein comprises the N-terminal region of the centrosomal protein FOP and the tyrosine kinase of the FGFR1 receptor. FOP-FGFR1 is localized at the centrosome where it exerts a constitutive kinase activity. Results We show that FOP-FGFR1 interacts with the large centrosomal protein CAP350 and that CAP350 is necessary for FOP-FGFR1 localisation at centrosome. FOP-FGFR1 activates the phosphoinositide-3 kinase (PI3K pathway. We show that p85 interacts with tyrosine 475 of FOP-FGFR1, which is located in a YXXM consensus binding sequence for an SH2 domain of p85. This interaction is in part responsible for PI3K activation. Ba/F3 cells that express FOP-FGFR1 mutated at tyrosine 475 have reduced proliferative ability. Treatment with PI3K pathway inhibitors induces death of FOP-FGFR1 expressing cells. FOP-FGFR1 also recruits phospholipase Cγ1 (PLCγ1 at the centrosome. We show that this enzyme is recruited by FOP-FGFR1 at the centrosome during interphase. Conclusion These results delineate a particular type of oncogenic mechanism by which an ectopic kinase recruits its substrates at the centrosome whence unappropriate signaling induces continuous cell growth and MPD.

  20. Characterization of methyl parathion degradation by a Burkholderia zhejiangensis strain, CEIB S4-3, isolated from agricultural soils.

    Science.gov (United States)

    Popoca-Ursino, Elida C; Martínez-Ocampo, Fernando; Dantán-González, Edgar; Sánchez-Salinas, Enrique; Ortiz-Hernández, Ma Laura

    2017-12-01

    Through the use of an enrichment technique, we isolated from the agricultural soils of Morelos in central México a strain of Burkholderia zhejiangensis identified as CEIB S4-3, it's could use the pesticide methyl parathion (MP) as the only source of carbon and degrade completely p-nitrophenol (PNP). For more efficient MP and PNP degradation by the CEIB S4-3 strain, the absence of an extra carbon source, a large inoculum and an MP concentration up to 50 mg/l are required. Sequence and annotation analysis of the draft genome, showed presence of mpd functional gene, which was expressed and its activity on the MP was confirmed. Additionally, the genes coding for enzymes in the benzoquinone pathway (conducted by Gram-negative bacteria) and the benzenotriol pathway (conducted by Gram-positive bacteria) were found, which was corroborated by identification of intermediary metabolites by HPLC. Thus, we propose that B. zhejiangensis CEIB S4-3 uses both degradation pathways.

  1. First-principles screening of structural properties of intermetallic compounds on martensitic transformation

    Science.gov (United States)

    Lee, Joohwi; Ikeda, Yuji; Tanaka, Isao

    2017-11-01

    Martensitic transformation with good structural compatibility between parent and martensitic phases are required for shape memory alloys (SMAs) in terms of functional stability. In this study, first-principles-based materials screening is systematically performed to investigate the intermetallic compounds with the martensitic phases by focusing on energetic and dynamical stabilities as well as structural compatibility with the parent phase. The B2, D03, and L21 crystal structures are considered as the parent phases, and the 2H and 6M structures are considered as the martensitic phases. In total, 3384 binary and 3243 ternary alloys with stoichiometric composition ratios are investigated. It is found that 187 alloys survive after the screening. Some of the surviving alloys are constituted by the chemical elements already widely used in SMAs, but other various metallic elements are also found in the surviving alloys. The energetic stability of the surviving alloys is further analyzed by comparison with the data in Materials Project Database (MPD) to examine the alloys whose martensitic structures may cause further phase separation or transition to the other structures.

  2. Radioresistant canine hematopoietic cells

    International Nuclear Information System (INIS)

    Kawakami, T.G.; Shimizu, J.; Rosenblatt, L.S.; Goldman, M.

    1987-01-01

    Survival of dogs that are continuously exposed to a moderate dose-rate of gamma radiation (10 cGy/day) is dependent on the age of the dog at the time of exposure. Most dogs exposed postpartum to gamma radiation suffered from suppressed hematopoiesis and died of aplasia. On the other hand, none of the in utero-exposed dogs suffered from suppressed hematopoiesis and most became long-term survivors, tolerating 10-fold greater total dose, but dying of myeloproliferative disease (MPD). Using acute gamma irradiation of hematopoietic cells and colony forming unit cell assay (CFU), they observed that a canine hematopoietic cell line established from a myeloid leukemic dog that was a long-term survivor of continuous irradiation was approximately 4-fold more radioresistant than a hematopoietic cell line established from a dog with nonradiation-induced myeloid leukemia or hematopoietic cells from normal canine bone marrow. In utero dogs that are long-term survivors of continuous irradiation have radioresistant hematopoietic cells, and radioresistance that is a constitutive property of the cells

  3. Multiphoton ionization as a probe of molecular photofragmentation: statistical and dynamical energy partitioning in the multiphoton dissociation of nitromethane

    International Nuclear Information System (INIS)

    Rockney, B.H.

    1982-01-01

    Multiphoton ionization (MPI) appears in its first use as a probe of laser-induced photofragmentation. Specifically, MPI here reveals the internal and translational energy content of the nascent fragments from the infrared multiphoton dissociation (MPD) of nitromethane (CH 3 NO 2 ). The apparatus for this work consists of a pulsed supersonic molecular beam crossed by two pulsed and focused lasers - a CO 2 laser to induce collision-free unimolecular dissociation of CH 3 NO 2 , and a tunable dye laser following immediately to ionize selectively one of the pair of dissociation fragments for detection by a mass spectrometer and particle multiplier. A computer simulation of each fragment's MPI spectrum, a series of four photon resonances to members of the npsigma/sub u/ Rydberg state of NO 2 and three photon resonances to two vibrational members of the #betta# 1 Rydberg state of CH 3 , aids in determining the fragment's internal energy content. The dye laser is delayed and its focus is traced through a small quarter circle centered at the focus of the CO 2 laser. The flight times of the fragments from the point of dissociation and their laboratory scattering angular distributions at fixed ionizing laser wavelength provide their center of mass recoil velocity distributions. The energy deposited in the fragments evidences a striking mixture of statistical and dynamical energy partitioning. The statistical RRKM theory of unimolecular decomposition accurately predicts the amount of internal energy found in the fragments

  4. Use of Cutting-Edge Horizontal and Underbalanced Drilling Technologies and Subsurface Seismic Techniques to Explore, Drill and Produce Reservoired Oil and Gas from the Fractured Monterey Below 10,000 ft in the Santa Maria Basin of California

    Energy Technology Data Exchange (ETDEWEB)

    George Witter; Robert Knoll; William Rehm; Thomas Williams

    2006-06-30

    This project was undertaken to demonstrate that oil and gas can be drilled and produced safely and economically from a fractured Monterey reservoir in the Santa Maria Basin of California by employing horizontal wellbores and underbalanced drilling technologies. Two vertical wells were previously drilled in this area with heavy mud and conventional completions; neither was commercially productive. A new well was drilled by the project team in 2004 with the objective of accessing an extended length of oil-bearing, high-resistivity Monterey shale via a horizontal wellbore, while implementing managed-pressure drilling (MPD) techniques to avoid formation damage. Initial project meetings were conducted in October 2003. The team confirmed that the demonstration well would be completed open-hole to minimize productivity impairment. Following an overview of the geologic setting and local field experience, critical aspects of the application were identified. At the pre-spud meeting in January 2004, the final well design was confirmed and the well programming/service company requirements assigned. Various design elements were reduced in scope due to significant budgetary constraints. Major alterations to the original plan included: (1) a VSP seismic survey was delayed to a later phase; (2) a new (larger) surface hole would be drilled rather than re-enter an existing well; (3) a 7-in. liner would be placed into the top of the Monterey target as quickly as possible to avoid problems with hole stability; (4) evaluation activities were reduced in scope; (5) geosteering observations for fracture access would be deduced from penetration rate, cuttings description and hydrocarbon in-flow; and (6) rather than use nitrogen, a novel air-injection MPD system was to be implemented. Drilling operations, delayed from the original schedule by capital constraints and lack of rig availability, were conducted from September 12 to November 11, 2004. The vertical and upper curved sections were

  5. USE OF CUTTING-EDGE HORIZONTAL AND UNDERBALANCED DRILLING TECHNOLOGIES AND SUBSURFACE SEISMIC TECHNIQUES TO EXPLORE, DRILL AND PRODUCE RESERVOIRED OIL AND GAS FROM THE FRACTURED MONTEREY BELOW 10,000 FT IN THE SANTA MARIA BASIN OF CALIFORNIA

    Energy Technology Data Exchange (ETDEWEB)

    George Witter; Robert Knoll; William Rehm; Thomas Williams

    2005-02-01

    This project was undertaken to demonstrate that oil and gas can be drilled and produced safely and economically from a fractured Monterey reservoir in the Santa Maria Basin of California by employing horizontal wellbores and underbalanced drilling technologies. Two vertical wells were previously drilled in this area by Temblor Petroleum with heavy mud and conventional completions; neither was commercially productive. A new well was drilled by the project team in 2004 with the objective of accessing an extended length of oil-bearing, high-resistivity Monterey shale via a horizontal wellbore, while implementing managed-pressure drilling (MPD) techniques to avoid formation damage. Initial project meetings were conducted in October 2003. The team confirmed that the demonstration well would be completed open-hole to minimize productivity impairment. Following an overview of the geologic setting and local field experience, critical aspects of the application were identified. At the pre-spud meeting in January 2004, the final well design was confirmed and the well programming/service company requirements assigned. Various design elements were reduced in scope due to significant budgetary constraints. Major alterations to the original plan included: (1) a VSP seismic survey was delayed to a later phase; (2) a new (larger) surface hole would be drilled rather than re-enter an existing well; (3) a 7-in. liner would be placed into the top of the Monterey target as quickly as possible to avoid problems with hole stability; (4) evaluation activities were reduced in scope; (5) geosteering observations for fracture access would be deduced from penetration rate, cuttings description and hydrocarbon in-flow; and (6) rather than use nitrogen, a novel air-injection MPD system was to be implemented. Drilling operations, delayed from the original schedule by capital constraints and lack of rig availability, were conducted from September 12 to November 11, 2004. The vertical and upper

  6. Use of Cutting-Edge Horizontal and Underbalanced Drilling Technologies and Subsurface Seismic Techniques to Explore, Drill and Produce Reservoired Oil and Gas from the Fractured Monterey Below 10,000 ft in the Santa Maria Basin of California

    Energy Technology Data Exchange (ETDEWEB)

    George Witter; Robert Knoll; William Rehm; Thomas Williams

    2005-09-29

    This project was undertaken to demonstrate that oil and gas can be drilled and produced safely and economically from a fractured Monterey reservoir in the Santa Maria Basin of California by employing horizontal wellbores and underbalanced drilling technologies. Two vertical wells were previously drilled in this area with heavy mud and conventional completions; neither was commercially productive. A new well was drilled by the project team in 2004 with the objective of accessing an extended length of oil-bearing, high-resistivity Monterey shale via a horizontal wellbore, while implementing managed-pressure drilling (MPD) techniques to avoid formation damage. Initial project meetings were conducted in October 2003. The team confirmed that the demonstration well would be completed open-hole to minimize productivity impairment. Following an overview of the geologic setting and local field experience, critical aspects of the application were identified. At the pre-spud meeting in January 2004, the final well design was confirmed and the well programming/service company requirements assigned. Various design elements were reduced in scope due to significant budgetary constraints. Major alterations to the original plan included: (1) a VSP seismic survey was delayed to a later phase; (2) a new (larger) surface hole would be drilled rather than re-enter an existing well; (3) a 7-in. liner would be placed into the top of the Monterey target as quickly as possible to avoid problems with hole stability; (4) evaluation activities were reduced in scope; (5) geosteering observations for fracture access would be deduced from penetration rate, cuttings description and hydrocarbon in-flow; and (6) rather than use nitrogen, a novel air-injection MPD system was to be implemented. Drilling operations, delayed from the original schedule by capital constraints and lack of rig availability, were conducted from September 12 to November 11, 2004. The vertical and upper curved sections were

  7. 125I implantation combined with chemotherapy for treatment of local recurrent stage Ⅲ non-small cell lung cancer

    International Nuclear Information System (INIS)

    Luo Honglei; Yu Xiaojuan; Li Jin; Chen Xiaofei; He Jingdong

    2013-01-01

    Objective: To investigate the associated effect of 125 I implantation plus chemotherapy in local recurrent stage Ⅲ NSCLC patients. Methods: From January 2006 to January 2009, 34 patients documented with local recurrent stage Ⅲ NSCLC were divided into two groups by random number table. The treatment group was treated with 125 I permanent implantation combined with DP regimen (docetaxel 60 mg/m 2 + cisplatinum 75 mg/m 2 ), while the control group received only DP chemotherapy. According to the TPS, the treatment group received CT-guided percutaneous implantation of 125 I seeds with a particle activity of 2.22 ×10 7 -2.59 × 10 7 Bq. The prescribed dose was in the range of 90-110 Gy and the postoperatively matched peripheral dose (mPD) and D 90 were verified by TPS. The control group received a DP chemotherapy regime for 4 cycles after the procedure. This study was approved by the ethics committee,and all patients signed informed consents. The follow up time was up to disease progression. Kaplan-Meier survival analysis was used to describe the local lesion control (LLC) time and progression free survival (PFS). Log-rank test was used in the comparison of the survival rates between the two groups. Fisher's exact test was used to analyze the differences of CR rate and recent efficiency between two groups. Results: In the treatment group, postoperative mPD was 93.9-130.4 (M 116.7) Gy, and D 90 was 103.6-148.2 (M 130.6) Gy. The LLC time was 4.7 to 24.0 months with a median of 11.6 (95% CI: 8.7-14.6) months. In two cases, there was no recurrence during the follow-up time of 24 months.PFS was 4.7 to 24.0 months with a median of 10.5 (95% CI: 7.4-13.6) months. The recent effective rate of the treatment group was 64.7% (11/17).CR, PR, SD and PD were 41.2% (7/17), 23.5% (4/17), 23.5% (4/17) and 11.8% (2/17), respectively. In the control group, the LLC time was 4.5 to 11.4 months with a median of 7.5 (95 % CI: 6.7-8.3) months, and the median of PFS was 6.5 (4

  8. Relação entre bem-estar espiritual e transtornos psiquiátricos menores: estudo transversal Relationship between spiritual well-being and minor psychiatric disorders: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Sandra Maria Alexandre Volcan

    2003-08-01

    .3% of the sample. It was used a self-reported questionnaire with three instruments: 1 Spiritual Well-Being Scale (SWBS, 2 SRQ-20, and 3 a precoded questionnaire with questions on sociodemographic data, religious/spiritual practices, and stressful life events. Statistical analysis was performed using Chi-square test and logistic regression. RESULTS: Most of the students (80% declared that they had a spiritual belief and/or religious denomination. The mean score of spiritual well-being was 90.4 with scores 45.6 and 45.1 in the existential and religious subscales, respectively. SWBS showed an association with religious practices, but it was not influenced by sociodemographic and cultural variables. Subjects presenting low and moderate spiritual well-being showed a doubled risk of presenting minor psychiatric disorders (MPD (OR=0.42; 95%CI: 0.22-0.85. Subjects presenting low or moderate existential well-being showed almost five times more MPD (OR=0.19; 95%CI: 0.08-0.45. CONCLUSIONS: The study reveals spiritual well-being as a protection factor for minor psychiatric disorders, and that the results were mostly due to the Existential Well-Being subscale.

  9. The incidence of radioepidermitis and the dose-response relationship in parotid gland cancer patients treated with 125I seed brachytherapy. Incidence of radioepidermitis and the dose-response relationship

    Energy Technology Data Exchange (ETDEWEB)

    Mao, Ming-Hui; Zheng, Lei; Gao, Hong; Zhang, Jie; Liu, Shu-ming; Huang, Ming-wei; Shi, Yan [Peking University School and Hospital of Stomatology, Department of Oral and Maxillofacial Surgery, Beijing (China); Zhang, Jian-Guo [Peking University School and Hospital of Stomatology, Department of Oral and Maxillofacial Surgery, Beijing (China); Fujian Provincial Hospital, Fujian (China)

    2014-09-09

    We studied the incidence and dose-response relationship of radioepidermitis in parotid gland carcinoma patients treated with [{sup 125}I] seed brachytherapy in the hopes of designing an optimized pre-implant treatment plan that would reduce the incidence and severity of radioepidermitis in patients receiving this therapy. Between January 2007 and May 2010, 100 parotid gland cancer patients were treated postoperatively with [{sup 125}I] seed brachytherapy. The matched peripheral dose (MPD) was 80-140 Gy, and [{sup 125}I] seed activity was 0.7-0.8 mCi. The mean dose delivered to the skin was calculated in the post-implant CT on day 0 following implantation. Grades of acute and late dermatitis were evaluated at 2, 6, 12, and 18 months post-implantation. Most patients experienced grade 0-2 acute and late skin side effects (86 and 97 %, respectively), though a small subset developed severe complications. Most grade 1-3 effects resolved within 6 months of implantation, though some grade 1-3 effects and all grade 4 effects remained unchanged throughout the 18-month follow-up period. Grade 3 and 4 effects were most prominent (75 and 25 %, respectively) with doses of 110-140 Gy; doses higher than 140 Gy produced only grade 4 effects. [{sup 125}I] seed brachytherapy produced acceptable levels of acute and late radioepidermitis with a good clinical outcome. A mean dose under 100 Gy delivered to the skin was safe, though doses of 110-140 Gy should be given with caution and extra monitoring; doses greater than 140 Gy are dangerous and likely to produce grade 4-5 effects. (orig.) [German] Wir untersuchten die Inzidenz und die Dosis-Wirkung-Beziehung bei Patienten mit Ohrspeicheldruesenkrebs, die mit [{sup 125}I]-Seed-Brachytherapie behandelt wurden, in der Hoffnung, eine optimierte praeimplantologische Behandlung zu entwickeln, welche die Inzidenz und Schwere der Radioepidermitis bei Patienten, die diese Therapie erhalten haben, reduziert. Zwischen Januar 2007 und Mai 2010

  10. Purification, Crystallization, and Preliminary X-ray Analysis of Native Canavalin

    Science.gov (United States)

    Pusey, Marc; Dowell, Jennifer; Ng, Joseph; Gavira, Jose A.

    2003-01-01

    The protein canavalin is a 7S vicilin, from the Jack Bean, Canavalis ensfomis. Canavalin is described as a seed storage protein, an energy source for a developing seed, as no other known activity or function has been found. The protein was first isolated and crystallized by Sumner and Howell (J. Biol. Chem. 113, 607-610, 1936). Canavalin spontaneously crystallizes after proteolytic cleavage at neutral pH, which removes residues 1-46, 224-245, and 325-330 and produces peptides of approximately 25, 13, and 12 kDa. Preliminary gel filtration experiments indicated the presence of nucleic acid with the uncleaved protein. We developed a dual column procedure, ion exchange followed by hydroxy apatite chromatography, that effectively removes the nucleic acid and yields an essentially pure uncut canavalin preparation with an OD 280/260 ratio of approximately 1.9-2.0. Standard crystallization screens using this material gave a number of positive results having a common requirement for alcohols and Mg(2+) ion, with crystals typically appearing within a day or less. Optimization experiments to date have shown that we can obtain crystals from pH 6.5 to pH 8.2, using MPD from 5 to 20% and 0.05 to 0.2M Mg(2+) (sulfate or acetate). The crystals are of space group P2(sub 1)2(sub 1)2(sub 1), unit cell dimensions, and a complete data set to 1.5 Angstroms, resolution has now been collected at a synchrotron source. Most importantly, the crystals are not twinned, a persistent problem with the most commonly obtained rhombohedral form of proteolytically cleaved canavalin.

  11. PENERAPAN SUPERVISI KUNJUNGAN KELAS UNTUK MENINGKATKAN KINERJA GURU SD NEGERI 2 KALIMANGGIS KECAMATAN KALORAN, TEMANGGUNG

    Directory of Open Access Journals (Sweden)

    Suprih Danurwati

    2015-12-01

    Full Text Available Suprih Danurwati, 942013161. Implementation of supervision class visiting to increase teacher’s performance of SD Negeri 2 Kalimanggis District of Kaloran. Thesis. The graduatiton Program Master of Management Education Satya Wacana Christian University Salatiga. Supervisor Prof. Dr. Slameto, M.Pd. This study is to determine that through the implementation of supervision class visiting can improve the performance of teachers in the learning management. The subjects of this study are teachers in SD Negeri 2 Kalimanggis, Kaloran, Temanggung.  The procedure used in this study consists of a series of three main activities undertaken in a repeating cycle, including (a plan, (b action by observation, and (c reflection. research approach using action research methods, while the method of data collection using the study documentation, observations, questionnaires, and interviews. The results showed an increasing in the ability of teachers to prepare lesson plans and manage the learning of the first act, second, until the third act. The inference that supervision class visiting that can improve the performance of teachers in the learning management. Suggestions given to teachers, is taking  advantage of supervision activities as a source of information to improve the competence and performance, for principals use the results of this study as a reference in conducting research, while for school superintendent will use the results of this study as one of the references in activity guidance to the heads of schools and teachers to improve their performance.

  12. Repeated batch and continuous degradation of chlorpyrifos by Pseudomonas putida.

    Science.gov (United States)

    Pradeep, Vijayalakshmi; Subbaiah, Usha Malavalli

    2015-01-01

    The present study was undertaken with the objective of studying repeated batch and continuous degradation of chlorpyrifos (O,O-diethyl O-3,5,6-trichloropyridin-2-yl phosphorothioate) using Ca-alginate immobilized cells of Pseudomonas putida isolated from an agricultural soil, and to study the genes and enzymes involved in degradation. The study was carried out to reduce the toxicity of chlorpyrifos by degrading it to less toxic metabolites. Long-term stability of pesticide degradation was studied during repeated batch degradation of chlorpyrifos, which was carried out over a period of 50 days. Immobilized cells were able to show 65% degradation of chlorpyrifos at the end of the 50th cycle with a cell leakage of 112 × 10(3) cfu mL(-1). During continuous treatment, 100% degradation was observed at 100 mL h(-1) flow rate with 2% chlorpyrifos, and with 10% concentration of chlorpyrifos 98% and 80% degradation was recorded at 20 mL h(-1) and 100 mL h(-1) flow rate respectively. The products of degradation detected by liquid chromatography-mass spectrometry analysis were 3,5,6-trichloro-2-pyridinol and chlorpyrifos oxon. Plasmid curing experiments with ethidium bromide indicated that genes responsible for the degradation of chlorpyrifos are present on the chromosome and not on the plasmid. The results of Polymerase chain reaction indicate that a ~890-bp product expected for mpd gene was present in Ps. putida. Enzymatic degradation studies indicated that the enzymes involved in the degradation of chlorpyrifos are membrane-bound. The study indicates that immobilized cells of Ps. putida have the potential to be used in bioremediation of water contaminated with chlorpyrifos.

  13. Metabolic and mitochondrial dysfunction in early mouse embryos following maternal dietary protein intervention.

    Science.gov (United States)

    Mitchell, Megan; Schulz, Samantha L; Armstrong, David T; Lane, Michelle

    2009-04-01

    Dietary supply of nutrients, both periconception and during pregnancy, influence the growth and development of the fetus and offspring and their health into adult life. Despite the importance of research efforts surrounding the developmental origins of health and disease hypothesis, the biological mechanisms involved remain elusive. Mitochondria are of major importance in the oocyte and early embryo, particularly as a source of ATP generation, and perturbations in their function have been related to reduced embryo quality. The present study examined embryo development following periconception exposure of females to a high-protein diet (HPD) or a low-protein diet (LPD) relative to a medium-protein diet (MPD; control), and we hypothesized that perturbed mitochondrial metabolism in the mouse embryo may be responsible for the impaired embryo and fetal development reported by others. Although the rate of development to the blastocyst stage did not differ between diets, both the HPD and LPD reduced the number of inner cell mass cells in the blastocyst-stage embryo. Furthermore, mitochondrial membrane potential was reduced and mitochondrial calcium levels increased in the 2-cell embryo. Embryos from HPD females had elevated levels of reactive oxygen species and ADP concentrations, indicative of metabolic stress and, potentially, the uncoupling of oxidative phosphorylation, whereas embryos from LPD females had reduced mitochondrial clustering around the nucleus, suggestive of an overall quietening of metabolism. Thus, although periconception dietary supply of different levels of protein is permissive of development, mitochondrial metabolism is altered in the early embryo, and the nature of the perturbation differs between HPD and LPD exposure.

  14. A guide to phylogenetic metrics for conservation, community ecology and macroecology

    Science.gov (United States)

    Cadotte, Marc W.; Carvalho, Silvia B.; Davies, T. Jonathan; Ferrier, Simon; Fritz, Susanne A.; Grenyer, Rich; Helmus, Matthew R.; Jin, Lanna S.; Mooers, Arne O.; Pavoine, Sandrine; Purschke, Oliver; Redding, David W.; Rosauer, Dan F.; Winter, Marten; Mazel, Florent

    2016-01-01

    ABSTRACT The use of phylogenies in ecology is increasingly common and has broadened our understanding of biological diversity. Ecological sub‐disciplines, particularly conservation, community ecology and macroecology, all recognize the value of evolutionary relationships but the resulting development of phylogenetic approaches has led to a proliferation of phylogenetic diversity metrics. The use of many metrics across the sub‐disciplines hampers potential meta‐analyses, syntheses, and generalizations of existing results. Further, there is no guide for selecting the appropriate metric for a given question, and different metrics are frequently used to address similar questions. To improve the choice, application, and interpretation of phylo‐diversity metrics, we organize existing metrics by expanding on a unifying framework for phylogenetic information. Generally, questions about phylogenetic relationships within or between assemblages tend to ask three types of question: how much; how different; or how regular? We show that these questions reflect three dimensions of a phylogenetic tree: richness, divergence, and regularity. We classify 70 existing phylo‐diversity metrics based on their mathematical form within these three dimensions and identify ‘anchor’ representatives: for α‐diversity metrics these are PD (Faith's phylogenetic diversity), MPD (mean pairwise distance), and VPD (variation of pairwise distances). By analysing mathematical formulae and using simulations, we use this framework to identify metrics that mix dimensions, and we provide a guide to choosing and using the most appropriate metrics. We show that metric choice requires connecting the research question with the correct dimension of the framework and that there are logical approaches to selecting and interpreting metrics. The guide outlined herein will help researchers navigate the current jungle of indices. PMID:26785932

  15. Mapping genetic variants associated with beta-adrenergic responses in inbred mice.

    Directory of Open Access Journals (Sweden)

    Micha Hersch

    Full Text Available β-blockers and β-agonists are primarily used to treat cardiovascular diseases. Inter-individual variability in response to both drug classes is well recognized, yet the identity and relative contribution of the genetic players involved are poorly understood. This work is the first genome-wide association study (GWAS addressing the values and susceptibility of cardiovascular-related traits to a selective β(1-blocker, Atenolol (ate, and a β-agonist, Isoproterenol (iso. The phenotypic dataset consisted of 27 highly heritable traits, each measured across 22 inbred mouse strains and four pharmacological conditions. The genotypic panel comprised 79922 informative SNPs of the mouse HapMap resource. Associations were mapped by Efficient Mixed Model Association (EMMA, a method that corrects for the population structure and genetic relatedness of the various strains. A total of 205 separate genome-wide scans were analyzed. The most significant hits include three candidate loci related to cardiac and body weight, three loci for electrocardiographic (ECG values, two loci for the susceptibility of atrial weight index to iso, four loci for the susceptibility of systolic blood pressure (SBP to perturbations of the β-adrenergic system, and one locus for the responsiveness of QTc (p<10(-8. An additional 60 loci were suggestive for one or the other of the 27 traits, while 46 others were suggestive for one or the other drug effects (p<10(-6. Most hits tagged unexpected regions, yet at least two loci for the susceptibility of SBP to β-adrenergic drugs pointed at members of the hypothalamic-pituitary-thyroid axis. Loci for cardiac-related traits were preferentially enriched in genes expressed in the heart, while 23% of the testable loci were replicated with datasets of the Mouse Phenome Database (MPD. Altogether these data and validation tests indicate that the mapped loci are relevant to the traits and responses studied.

  16. Leukemia Associated Antigens: Their Dual Role as Biomarkers and Immunotherapeutic Targets for Acute Myeloid Leukemia

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    Michael Schmitt

    2007-01-01

    Full Text Available Leukemia associated antigens (LAAs are being increasingly identified by methods such as cytotoxic T-lymphocyte (CTL cloning, serological analysis of recombinant cDNA expression libraries (SEREX and mass spectrometry (MS. In additional, large scale screening techniques such as microarray, single nucleotide polymorphisms (SNPs, serial analysis of gene expression (SAGE and 2-dimensional gel electrophoresis (2-DE have expanded our understanding of the role that tumor antigens play in the biological processes which are perturbed in acute myeloid leukemia (AML. It has become increasingly apparent that these antigens play a dual role, not only as targets for immunotherapy, but also as biomarkers of disease state, stage, response to treatment and survival. We need biomarkers to enable the identification of the patients who are most likely to benefit from specific treatments (conventional and/or novel and to help clinicians and scientists improve clinical end points and treatment design. Here we describe the LAAs identified in AML, to date, which have already been shown to play a dual role as biomarkers of AML disease.Abbreviations: AML: acute myeloid leukemia; APL: acute promyelocytic leukemia; ATRA: all-trans-retinoic acid; B-CLL: B-cell chronic lymphocytic leukemia; CT: cancer-testis; CTL: cytotoxic T-lymphocyte; FAB: French-American-British; HI: hypusination inhibitors; HSP: heat shock protein; ITD: internal tandem duplication; LAA: leukemia associated antigen; MDS: myelodysplastic syndrome; MGEA6: meningioma antigen 6; MPD: myeloproliferative disease; MS: mass spectrometry; NK: natural killer; PRAME: preferentially expressed antigen of melanoma; PRTN3: proteinase 3; RAGE-1: renal antigen 1; RHAMM: receptor for hyaluronic acid-mediated motility; RQ-PCR: real-time PCR; SAGE: serial analysis of gene expression; SCT: stem cell transplant; SEREX: serological analysis of recombinant cDNA expression libraries; SNPs: single nucleotide polymorphisms; UPD

  17. Automated treatment planning engine for prostate seed implant brachytherapy

    International Nuclear Information System (INIS)

    Yu Yan; Zhang, J.B.Y.; Brasacchio, Ralph A.; Okunieff, Paul G.; Rubens, Deborah J.; Strang, John G.; Soni, Arvind; Messing, Edward M.

    1999-01-01

    Purpose: To develop a computer-intelligent planning engine for automated treatment planning and optimization of ultrasound- and template-guided prostate seed implants. Methods and Materials: The genetic algorithm was modified to reflect the 2D nature of the implantation template. A multi-objective decision scheme was used to rank competing solutions, taking into account dose uniformity and conformity to the planning target volume (PTV), dose-sparing of the urethra and the rectum, and the sensitivity of the resulting dosimetry to seed misplacement. Optimized treatment plans were evaluated using selected dosimetric quantifiers, dose-volume histogram (DVH), and sensitivity analysis based on simulated seed placement errors. These dosimetric planning components were integrated into the Prostate Implant Planning Engine for Radiotherapy (PIPER). Results: PIPER has been used to produce a variety of plans for prostate seed implants. In general, maximization of the minimum peripheral dose (mPD) for given implanted total source strength tended to produce peripherally weighted seed patterns. Minimization of the urethral dose further reduced the loading in the central region of the PTV. Isodose conformity to the PTV was achieved when the set of objectives did not reflect seed positioning uncertainties; the corresponding optimal plan generally required fewer seeds and higher source strength per seed compared to the manual planning experience. When seed placement uncertainties were introduced into the set of treatment planning objectives, the optimal plan tended to reach a compromise between the preplanned outcome and the likelihood of retaining the preferred outcome after implantation. The reduction in the volatility of such seed configurations optimized under uncertainty was verified by sensitivity studies. Conclusion: An automated treatment planning engine incorporating real-time sensitivity analysis was found to be a useful tool in dosimetric planning for prostate

  18. Clinical efficacy of CT-guided 125I seed implantation therapy for advanced pancreatic cancer

    International Nuclear Information System (INIS)

    Wang Zhongmin; Lu Jian; Gong Ju; Zheng Yunfeng; Zhang Liyun; Huang Gang; Chen Kemin

    2009-01-01

    Objective: To discuss the clinical efficacy of CT-guided radioactive 125 I seed implantation treatment for unresectable pancreatic cancer. Methods: Forty patients with inoperable pancreatic cancer were enrolled in this study, including 25 males and 15 females with an median age of 69 years (38-89 years). Treatment planning system (TPS) was used to reconstruct 3-dimensional images of pancreatic tumor and to define the quantity and distribution of 125 I seeds. The radioactivity of 125 I seeds was 0.5 - 0.8 mCi / seed. The seeds were implanted into pancreatic tumor under CT guidance at intervals of 1 cm and were kept away from vessels, pancreatic duct and other adjacent important organs. The tumor matched peripheral dose (MPD) was 60-140 Gy. The median amount of implanted 125 I seeds was 36 (18-68) in number. CT scan was performed immediately after the procedure to check the quality of the seeds. In addition, 10 patients received concurrent chemotherapy with arterial infusion of gemcitabin and 5-fluororacil (5-Fu) for 3 to 4 therapeutic courses. Results: The median diameter of the tumors was 4.9 cm. The follow-up period was 2 to 28 months. After the treatment the refractory pain was significantly relieved (P 125 I seed implantation is a safe, effective and minimally-invasive brachytherapy for unresectable pancreatic cancer with reliable short-term efficacy. It has an excellent anti-pain effect. The curative results can be further improved when chemotherapy is employed together. However, its long-term efficacy needs to be observed. (authors)

  19. Seasonal dynamics of phytoplankton in two tropical rivers of varying size and human impact in Southeast Nigeria

    Directory of Open Access Journals (Sweden)

    Okechukwu Idumah Okogwu

    2013-12-01

    Full Text Available Phytoplankton occurrence and dynamics in rivers are mainly shaped by hydrophysical conditions and nutrient availability. Phytoplankton main structuring factors have been poorly studied in West African rivers, and this study was undertaken to identify these conditions in two tropical rivers that vary in size and human impact. For this, environmental variables and phytoplankton monthly samples were collected from the middle reaches of Asu and Cross rivers during an 18 months survey from March 2005-July 2006. Phytoplankton biomass (F=11.87, p=0.003, Shannon-Weiner diversity and species richness (F=5.93, p=0.003 showed significant seasonality in Asu but not in Cross River. Data was analyzed with Canonical correspondence analysis (CCA and showed environmental differences between the two rivers, nitrate in Asu River (5.1-15.5mg/L was significantly higher than Cross River (0.03-1.7mg/L, while PO4 (0.2-0.9mg/L was significantly lower in Asu River compared to Cross River (0.03-2.6mg/L (p<0.05. Eutrophic factors (NO3 determined primarily phytoplankton dynamics in Asu River, especially during the dry season, whereas hydrophysical factors (depth, transparency and temperature shaped phytoplankton in Cross River. Taxa indicative of an eutrophic condition, such as Euglena, Chlorella, Chlorococcus, Ceratium, Peridinium, Anabaena, Aphanizomenon, Closterium, Scenedesmus and Pediastrum spp., were frequently encountered in the shallow impounded Asu River, while riverine species, such as Frustulia rhomboids, Gyrosigma sp., Opephora martyr and Surirella splendida dominated Cross River. A succession pattern was observed in the functional groups identified: Na/MP→TB→P (rainy→dry season was observed in Asu River, whereas MP/D predominated in Cross River for both seasons. We concluded that, if nutrients predominate hydrophysical factors in shaping phytoplankton during dry season (half of the year then, they are as important as hydrophysical factors structuring

  20. Influence of breastfeeding and iron status on mental and psychomotor development during the first year of life.

    Science.gov (United States)

    Jardí, Cristina; Hernández-Martínez, Carmen; Canals, Josefa; Arija, Victoria; Bedmar, Cristina; Voltas, Núria; Aranda, Núria

    2018-02-01

    Breastfeeding (BF) confers numerous benefits on the developing infant in both the short and the long term including psychological development, but there are multiple other factors that must be taken into account when these relationships are studied. To analyse how breastfeeding during the first 4 months of life affects infant mental and psychomotor development (MPD) at 6 and 12 months in a group of healthy infants from a Mediterranean Spanish city considering many important potential confounds. This is a longitudinal study conducted on infants from birth until the age of 12 months. A total of 154 healthy infants were evaluated by Paediatric Unit of Sant Joan University Hospital in Reus, Spain. Type of feeding, clinical history, anthropometry, iron status and mental and psychomotor development were assessed and analysed. At 4 months, 24% of infants received BF and 26% received mixed feeding (MF). Multiple Linear Regression models were applied adjusting for potential prenatal, perinatal and postnatal confounds showing that infants who received BF for at least four months presented higher psychomotor development index (PDI) at 6 and at 12 months of age. Also, gestational age and BMI at 6m were associated positively with PDI at 6 m, and haemoglobin levels at 12m and birth height were associated with PDI and MDI at 12m (respectively). In conclusion, after the adjustment of important potential confounds, BF during at least four months and adequate infant iron status are related to better psychomotor development during the first year. No associations were found between BF and mental development. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. About miRNAs, miRNA seeds, target genes and target pathways.

    Science.gov (United States)

    Kehl, Tim; Backes, Christina; Kern, Fabian; Fehlmann, Tobias; Ludwig, Nicole; Meese, Eckart; Lenhof, Hans-Peter; Keller, Andreas

    2017-12-05

    miRNAs are typically repressing gene expression by binding to the 3' UTR, leading to degradation of the mRNA. This process is dominated by the eight-base seed region of the miRNA. Further, miRNAs are known not only to target genes but also to target significant parts of pathways. A logical line of thoughts is: miRNAs with similar (seed) sequence target similar sets of genes and thus similar sets of pathways. By calculating similarity scores for all 3.25 million pairs of 2,550 human miRNAs, we found that this pattern frequently holds, while we also observed exceptions. Respective results were obtained for both, predicted target genes as well as experimentally validated targets. We note that miRNAs target gene set similarity follows a bimodal distribution, pointing at a set of 282 miRNAs that seems to target genes with very high specificity. Further, we discuss miRNAs with different (seed) sequences that nonetheless regulate similar gene sets or pathways. Most intriguingly, we found miRNA pairs that regulate different gene sets but similar pathways such as miR-6886-5p and miR-3529-5p. These are jointly targeting different parts of the MAPK signaling cascade. The main goal of this study is to provide a general overview on the results, to highlight a selection of relevant results on miRNAs, miRNA seeds, target genes and target pathways and to raise awareness for artifacts in respective comparisons. The full set of information that allows to infer detailed results on each miRNA has been included in miRPathDB, the miRNA target pathway database (https://mpd.bioinf.uni-sb.de).

  2. ORGANIZAÇÃO DA COMUNIDADE E ESTRUTURA FILOGENÉTICA DO COMPONENTE ARBÓREO DE UM FRAGMENTO DE FLORESTA NEBULAR NO PLANALTO CATARINENSE

    Directory of Open Access Journals (Sweden)

    Ana Carolina da Silva

    2017-01-01

    Full Text Available This study aimed to survey the community organization and the phylogenetic structure of tree species component in a nebular forest, in the municipality of Urubici, Santa Catarina state. A total of 25 plots (400 m 2 were allocated, where all trees with circumference at breast height (cbh equal or superior than 15.7 cm were measured (cbh and identified. The Shannon index and phytosociological descriptors were determined. The dispersal syndromes of propagules were determined and the spatial distribution of each species was analyzed. The phylogenetic structure was evaluated by the values of ‘Mean Pairwise Distance’ (MPD and Net Relatedness Index (NRI, determined through a phylogenetic tree built in function of the species sampled, an abundance matrix of species by plots and 1,000 simulations of a community with phylogenetic randomness organization. The spatial structure of the phylogenetic metrics was analyzed through I Moran Index. A total of 1,579 trees were sampled, belonging to 33 species, with Myrtaceae as the richest family. The low value of diversity (2.43, associated to low richness, is expected for nebular forest, where the environment is typically selective. The most representative species in the forest was Myrceugenia euosma (O.Berg D.Legrand (VI = 24.51%. The predominant dispersal syndrome was zoochory (84.85%, followed by anemochory (15.15%; and the species showed predominantly a clustered spatial distribution. The community had variation in relation to the phylogenetic structure, with most plots showing no significant difference from the null model of complete randomness.

  3. Data-Centric Situational Awareness and Management in Intelligent Power Systems

    Science.gov (United States)

    Dai, Xiaoxiao

    The rapid development of technology and society has made the current power system a much more complicated system than ever. The request for big data based situation awareness and management becomes urgent today. In this dissertation, to respond to the grand challenge, two data-centric power system situation awareness and management approaches are proposed to address the security problems in the transmission/distribution grids and social benefits augmentation problem at the distribution-customer lever, respectively. To address the security problem in the transmission/distribution grids utilizing big data, the first approach provides a fault analysis solution based on characterization and analytics of the synchrophasor measurements. Specically, the optimal synchrophasor measurement devices selection algorithm (OSMDSA) and matching pursuit decomposition (MPD) based spatial-temporal synchrophasor data characterization method was developed to reduce data volume while preserving comprehensive information for the big data analyses. And the weighted Granger causality (WGC) method was investigated to conduct fault impact causal analysis during system disturbance for fault localization. Numerical results and comparison with other methods demonstrate the effectiveness and robustness of this analytic approach. As more social effects are becoming important considerations in power system management, the goal of situation awareness should be expanded to also include achievements in social benefits. The second approach investigates the concept and application of social energy upon the University of Denver campus grid to provide management improvement solutions for optimizing social cost. Social element--human working productivity cost, and economic element--electricity consumption cost, are both considered in the evaluation of overall social cost. Moreover, power system simulation, numerical experiments for smart building modeling, distribution level real-time pricing and social

  4. Growth in individuals with Majewski osteodysplastic primordial dwarfism type II caused by pericentrin mutations.

    Science.gov (United States)

    Bober, Michael B; Niiler, Tim; Duker, Angela L; Murray, Jennie E; Ketterer, Tara; Harley, Margaret E; Alvi, Sabah; Flora, Christina; Rustad, Cecilie; Bongers, Ernie M H F; Bicknell, Louise S; Wise, Carol; Jackson, Andrew P

    2012-11-01

    Microcephalic primordial dwarfism (MPD) is a class of disorders characterized by intrauterine growth restriction (IUGR), impaired postnatal growth and microcephaly. Majewski osteodysplastic primordial dwarfism type II (MOPD II) is one of the more common conditions within this group. MOPD II is caused by truncating mutations in pericentrin (PCNT) and is inherited in an autosomal recessive manner. Detailed growth curves for length, weight, and OFC are presented here and derived from retrospective data from 26 individuals with MOPD II confirmed by molecular or functional studies. Severe pre- and postnatal growth failure is evident in MOPD II patients. The length, weight, and OFC at term (when corrected for gestational age) were -7.0, -3.9, and -4.6 standard deviation (SD) below the population mean and equivalent to the 50th centile of a 28-29-, 31-32-, and 30-31-week neonate, respectively. While at skeletal maturity, the height, weight, and OFC were -10.3, -14.3, and -8.5 SD below the population mean and equivalent to the size of 3-year 10- to 11-month-old, a 5-year 2- to 3-month-old, and 5- to 6-month-old, respectively. During childhood, MOPD II patients grow with slowed, but fairly constant growth velocities and show no evidence of any pubertal growth spurt. Treatment with human growth hormone (n = 11) did not lead to any significant improvement in final stature. The growth charts presented here will be of assistance with diagnosis and management of MOPD II, and should have particular utility in nutritional management of MOPD II during infancy. Copyright © 2012 Wiley Periodicals, Inc.

  5. MPL mutation profile in JAK2 mutation-negative patients with myeloproliferative disorders.

    Science.gov (United States)

    Ma, Wanlong; Zhang, Xi; Wang, Xiuqiang; Zhang, Zhong; Yeh, Chen-Hsiung; Uyeji, Jennifer; Albitar, Maher

    2011-03-01

    Mutations in the thrombopoietin receptor gene (myeloproliferative leukemia, MPL) have been reported in patients with JAK2 V617F-negative chronic myeloproliferative disorders (MPDs). We evaluated the prevalence of MPL mutations relative to JAK2 mutations in patients with suspected MPDs. A total of 2790 patient samples submitted for JAK2 mutation analysis were tested using real-time polymerase chain reaction and bidirectional sequencing of plasma RNA. JAK2 V617F-negative samples were tested for JAK2 exons 12 to 14 mutations, and those with negative results were then tested for mutations in MPL exons 10 and 11. Of the 2790 patients, 529 (18.96%) had V617F, 12 (0.43%) had small insertions or deletions in exon 12, and 7 (0.25%) had other JAK2 mutations in exons 12 to 14. Of the 2242 JAK2 mutation-negative patients, 68 (3.03%) had MPL mutations. W515L was the predominant MPL mutation (n=46; 68%), and 10 (15%) patients had other W515 variants. The remaining MPL mutations (n=12, 17%) were detected at other locations in exons 10 and 11 and included 3 insertion/deletion mutations. The S505N mutation, associated with familial MPD, was detected in 3 patients. Overall, for every 100 V617F mutations in patients with suspected MPDs, there were 12.9 MPL mutations, 2.3 JAK2 exon 12 mutations, and 1.3 JAK2 exons 13 to 14 mutations. These findings suggest that MPL mutation screening should be performed before JAK2 exons 12 to 14 testing in JAK2 V617F-negative patients with suspected MPDs.

  6. Treatment of primary unresectable carcinoma of the pancreas with I-125 implantation

    Energy Technology Data Exchange (ETDEWEB)

    Peretz, T.; Nori, D.; Hilaris, B.; Manolatos, S.; Linares, L.; Harrison, L.; Anderson, L.L.; Fuks, Z.; Brennan, M.F. (Memorial Sloan-Kettering Cancer Center, New York, NY (USA))

    1989-11-01

    Between January 1 1974 and October 31 1987, 98 patients with biopsy proven unresectable adenocarcinoma of the pancreas were treated with I-125 implants during laparotomy. Presenting symptoms were pain, jaundice, and weight loss. All patients underwent laparotomy and surgical staging. Thirty patients had T1NoMo disease, 47 patients had T2-3NoMo disease, and 21 patients had significant regional lymph node involvement (T1-3N1Mo). The surgical procedure performed was biopsy only (16 patients), gastric bypass, biliary bypass, and partial or total pancreatectomy with incomplete resection. The total activity and the number of seeds used were determined from the Memorial Sloan Kettering Cancer Center (MSKCC) nomogram. Stereoshift localization X ray films were taken 3-6 days after operation. The mean activity, minimal peripheral dose (MPD), and volume of the implants were 35 mCi, 13,660 cGy, and 53 cm3, respectively. In addition, 27 patients received postoperative external irradiation and 27 patients received chemotherapy. Postoperative complications were observed in 19 patients. These included post-operative death (1 patient), biliary fistula (4), intraabdominal abscess (4), GI bleeding (3), gastric or small bowel obstruction (6), sepsis (5), and deep vein thrombophlebitis (4). Pain relief was obtained in 37/57 patients (65%) presenting with pain. A multivariate analysis showed that four factors significantly affected survival: T stage, N stage, administration of chemotherapy, and more than 30% reduction in the size of the implant on follow-up films. The median survival for the entire group was 7 months. A subgroup of patients with T1No stage disease who received chemotherapy survived 18.5 months. The indications for I-125 seed implantation in unresectable carcinoma of the pancreas are discussed.

  7. Treatment of primary unresectable carcinoma of the pancreas with I-125 implantation

    International Nuclear Information System (INIS)

    Peretz, T.; Nori, D.; Hilaris, B.; Manolatos, S.; Linares, L.; Harrison, L.; Anderson, L.L.; Fuks, Z.; Brennan, M.F.

    1989-01-01

    Between January 1 1974 and October 31 1987, 98 patients with biopsy proven unresectable adenocarcinoma of the pancreas were treated with I-125 implants during laparotomy. Presenting symptoms were pain, jaundice, and weight loss. All patients underwent laparotomy and surgical staging. Thirty patients had T1NoMo disease, 47 patients had T2-3NoMo disease, and 21 patients had significant regional lymph node involvement (T1-3N1Mo). The surgical procedure performed was biopsy only (16 patients), gastric bypass, biliary bypass, and partial or total pancreatectomy with incomplete resection. The total activity and the number of seeds used were determined from the Memorial Sloan Kettering Cancer Center (MSKCC) nomogram. Stereoshift localization X ray films were taken 3-6 days after operation. The mean activity, minimal peripheral dose (MPD), and volume of the implants were 35 mCi, 13,660 cGy, and 53 cm3, respectively. In addition, 27 patients received postoperative external irradiation and 27 patients received chemotherapy. Postoperative complications were observed in 19 patients. These included post-operative death (1 patient), biliary fistula (4), intraabdominal abscess (4), GI bleeding (3), gastric or small bowel obstruction (6), sepsis (5), and deep vein thrombophlebitis (4). Pain relief was obtained in 37/57 patients (65%) presenting with pain. A multivariate analysis showed that four factors significantly affected survival: T stage, N stage, administration of chemotherapy, and more than 30% reduction in the size of the implant on follow-up films. The median survival for the entire group was 7 months. A subgroup of patients with T1No stage disease who received chemotherapy survived 18.5 months. The indications for I-125 seed implantation in unresectable carcinoma of the pancreas are discussed

  8. X-ray analysis of bilirubin oxidase from Myrothecium verrucaria at 2.3 Å resolution using a twinned crystal

    International Nuclear Information System (INIS)

    Mizutani, Kimihiko; Toyoda, Mayuko; Sagara, Kenta; Takahashi, Nobuyuki; Sato, Atsuko; Kamitaka, Yuji; Tsujimura, Seiya; Nakanishi, Yuji; Sugiura, Toshiyuki; Yamaguchi, Shotaro; Kano, Kenji; Mikami, Bunzo

    2010-01-01

    The crystal structure of bilirubin oxidase (BOD) from M. verrucaria has been determined at 2.3 Å resolution using a merohedrally twinned crystal. BOD has four copper-coordination sites that are almost identical to those of other multicopper oxidases and is also very similar to them in overall structure. Bilirubin oxidase (BOD), a multicopper oxidase found in Myrothecium verrucaria, catalyzes the oxidation of bilirubin to biliverdin. Oxygen is the electron acceptor and is reduced to water. BOD is used for diagnostic analysis of bilirubin in serum and has attracted considerable attention as an enzymatic catalyst for the cathode of biofuel cells that work under neutral conditions. Here, the crystal structure of BOD is reported for the first time. Blue bipyramid-shaped crystals of BOD obtained in 2-methyl-2,4-pentanediol (MPD) and ammonium sulfate solution were merohedrally twinned in space group P6 3 . Structure determination was achieved by the single anomalous diffraction (SAD) method using the anomalous diffraction of Cu atoms and synchrotron radiation and twin refinement was performed in the resolution range 33–2.3 Å. The overall organization of BOD is almost the same as that of other multicopper oxidases: the protein is folded into three domains and a total of four copper-binding sites are found in domains 1 and 3. Although the four copper-binding sites were almost identical to those of other multicopper oxidases, the hydrophilic Asn residue (at the same position as a hydrophobic residue such as Leu in other multicopper oxidases) very close to the type I copper might contribute to the characteristically high redox potential of BOD

  9. Pancreatic MRI for the surveillance of cystic neoplasms: Comparison of a short with a comprehensive imaging protocol

    International Nuclear Information System (INIS)

    Pozzi-Mucelli, Raffaella Maria; Kartalis, Nikolaos; Rinta-Kiikka, Irina; Wuensche, Katharina; Laukkarinen, Johanna; Labori, Knut Joergen; Aanonsen, Kim; Verbeke, Caroline; Del Chiaro, Marco

    2017-01-01

    The study aims were to evaluate: (1) whether a short-protocol (SP) MRI for the surveillance of pancreatic cystic neoplasms (PCN) provides equivalent clinical information as a comprehensive-protocol (CP), and (2) the cost reduction from substituting CP with SP for patient surveillance. This retrospective study included 154 consecutive patients (median age: 66, 52 % men) with working-diagnosis of PCN and available contrast-enhanced MRI/MRCP. Three radiologists evaluated independently two imaging sets (SP/CP) per patient. The CP included: T2-weighted (HASTE/MRCP), DWI and T1-weighted (chemical-shift/pre-/post-contrast) images [acquisition time (AT) ∼ 35 min], whereas the SP included: T2-weighted HASTE and T1-weighted pre-contrast images (AT ∼ 8 min). Mean values of largest cyst/main pancreatic duct diameter (D_C/D_M_P_D) were compared. Agreement regarding presence/absence of cystic/MPD mural nodules (MN_C/MN_M_P_D), inter-observer agreement and cost differences between SP/CP were calculated. For D_C and D_M_P_D, mean values with SP/CP were 21.4/21.7 mm and 3.52/3.58 mm, while mean differences SP-CP were 0.3 mm (p = 0.02) and 0.06 mm (p = 0.12), respectively. For presence/absence of MN_C and MN_M_P_D, SP/CP coincided in 93 % and 98 % of cases, respectively. Inter-observer agreement was strong for SP/CP. SP-cost was 25 % of CP-cost. For the surveillance of PCN, short-protocol MRI provides information equivalent to the more time-consuming and costly comprehensive-protocol. (orig.)

  10. Bacterial Activity and Their Physiological Characteristics in the Sediments of O DP Holes 1202A and 1202D, Okinawa Trough, Western Pacific

    Directory of Open Access Journals (Sweden)

    Jiin-Shuh Jean

    2005-01-01

    Full Text Available Bacterial strains were isolated and identified from the down-core sediments of Site 1202 of ODP Leg 195 in the Okinawa Trough. Their phylogenetic relationships and physiological characteristics were determined. The isolates were cultured in aerobic and anaerobic sulfate-reducing and fermentative media at temperatures of _ and _ The results showed that there were gram-positive/negative rod- and/or sphere-shaped bacteria in the sediments at all depths from 3 to 358.3 meters below the seafloor (mbsf, but no bacteria were present at depths greater than 358.3 mbsf (> 64.73 ka in age of sediment were isolated (maximum core depth 406.5 mbsf. On the basis of the nucleotide similarities of 16S rDNA and reconstructed phylogeny, the bacterial isolates of the sediments of 10.1 mbsf (1202A002H and 241.2 mbsf (1202D027X were shown to share high identities with the Bacillus subtilis and Pseudomonas putida or _ MPD-98 strains. Physiological experiments showed that the optimal temperature for growth of the studied bacteria was _ but the bacteria obtained at some depths could tolerate temperatures up to _ The maximum salinity allowed for the growth of the cultured bacteria was 60 _ 650/00. The optimal pH for bacterial growth was 7.0 - 8.3. None of the bacteria extracted from the studied sediments could survive at pH _ or _ These halotolerant bacteria were capable of making consumption of Fe, Cu2+ , Na+, K+, Mg2+ , Ca2+, and F−, but no biogenic minerals could be identified in the present study.

  11. 'Bimodal' Nuclear Thermal Rocket (BNTR) propulsion for an artificial gravity HOPE mission to Callisto

    International Nuclear Information System (INIS)

    Borowski, Stanley K.; McGuire, Melissa L.; Mason, Lee M.; Gilland, James H.; Packard, Thomas W.

    2003-01-01

    This paper summarizes the results of a year long, multi-center NASA study which examined the viability of nuclear fission propulsion systems for Human Outer Planet Exploration (HOPE). The HOPE mission assumes a crew of six is sent to Callisto. Jupiter's outermost large moon, to establish a surface base and propellant production facility. The Asgard asteroid formation, a region potentially rich in water-ice, is selected as the landing site. High thrust BNTR propulsion is used to transport the crew from the Earth-Moon L1 staging node to Callisto then back to Earth in less than 5 years. Cargo and LH2 'return' propellant for the piloted Callisto transfer vehicle (PCTV) is pre-deployed at the moon (before the crew's departure) using low thrust, high power, nuclear electric propulsion (NEP) cargo and tanker vehicles powered by hydrogen magnetoplasmadynamic (MPD) thrusters. The PCTV is powered by three 25 klbf BNTR engines which also produce 50 kWe of power for crew life support and spacecraft operational needs. To counter the debilitating effects of long duration space flight (∼855 days out and ∼836 days back) under '0-gE' conditions, the PCTV generates an artificial gravity environment of '1-gE' via rotation of the vehicle about its center-of-mass at a rate of ∼4 rpm. After ∼123 days at Callisto, the 'refueled' PCTV leaves orbit for the trip home. Direct capsule re-entry of the crew at mission end is assumed. Dynamic Brayton power conversion and high temperature uranium dioxide (UO2) in tungsten metal ''cermet'' fuel is used in both the BNTR and NEP vehicles to maximize hardware commonality. Technology performance levels and vehicle characteristics are presented, and requirements for PCTV reusability are also discussed

  12. Trichostatin A Enhances the Apoptotic Potential of Palladium Nanoparticles in Human Cervical Cancer Cells

    Directory of Open Access Journals (Sweden)

    Xi-Feng Zhang

    2016-08-01

    Full Text Available Cervical cancer ranks seventh overall among all types of cancer in women. Although several treatments, including radiation, surgery and chemotherapy, are available to eradicate or reduce the size of cancer, many cancers eventually relapse. Thus, it is essential to identify possible alternative therapeutic approaches for cancer. We sought to identify alternative and effective therapeutic approaches, by first synthesizing palladium nanoparticles (PdNPs, using a novel biomolecule called saponin. The synthesized PdNPs were characterized by several analytical techniques. They were significantly spherical in shape, with an average size of 5 nm. Recently, PdNPs gained much interest in various therapies of cancer cells. Similarly, histone deacetylase inhibitors are known to play a vital role in anti-proliferative activity, gene expression, cell cycle arrest, differentiation and apoptosis in various cancer cells. Therefore, we selected trichostatin A (TSA and PdNPs and studied their combined effect on apoptosis in cervical cancer cells. Cells treated with either TSA or PdNPs showed a dose-dependent effect on cell viability. The combinatorial effect, tested with 50 nM TSA and 50 nMPdNPs, had a more dramatic inhibitory effect on cell viability, than either TSA or PdNPs alone. The combination of TSA and PdNPs had a more pronounced effect on cytotoxicity, oxidative stress, mitochondrial membrane potential (MMP, caspase-3/9 activity and expression of pro- and anti-apoptotic genes. Our data show a strong synergistic interaction between TSA and PdNPs in cervical cancer cells. The combinatorial treatment increased the therapeutic potential and demonstrated relevant targeted therapy for cervical cancer. Furthermore, we provide the first evidence for the combinatory effect and cytotoxicity mechanism of TSA and PdNPs in cervical cancer cells.

  13. Health effects of occupational exposure to hazardous chemicals: a comparative assessment with notes on ionizing radiation. Executive summary. Vol. 1

    International Nuclear Information System (INIS)

    Zanetos, M.A.; Warling, J.C.; Marsh, G.M.

    1983-09-01

    This three-part report provides quantitative estimates of the risk of cancer and other diseases among persons exposed to hazardous substances in the workplace. The risk estimates presented are based on a comprehensive review of recent epidemiologic studies. Primary emphasis was placed on studies of workers exposed to hazardous chemicals under conditions typical of a given industry over a working lifetime. Despite finding over 100 chemicals associated with increased incidence of disease, convincing dose-response trends existed for only a few. Although there were notable exceptions (arsenic, asbestos, PAH's, etc.), it was generally impossible to estimate risk-per-unit of dose in a manner analogous to calculations which exist for radiation exposure. The principal reason for this is the lack of adequate environmental monitoring data for the specific chemicals, locations, and time periods needed to estimate individual cumulative doses. In addition to analyzing risk in terms of increased incidence of specific diseases, we also examined life expectancy and years of life lost due to cancer in four selected occupational groups via a life table model which allowed for competing risks. The resulting estimates indicated that the overall life expectancy of these groups was generally greater than that of the general population but that the workers suffered greater loss of life expectancy (LLE) due to cancer than their counterparts in the general population. Published estimates of LLE due to radiation induced cancer indicate that at doses of less than or equal to 0.5 rem/y, radiation workers are projected to suffer less LLE than any of the four non-nuclear cohorts examined. At 5 rem/y (the MPD) or higher, LLE may be greater than one or more of the cohorts examined. This is Volume I of a three volume series. 12 references

  14. The PEGASUS Drive: A nuclear electric propulsion system for the space exploration initiative

    International Nuclear Information System (INIS)

    Coomes, E.P.; Dagle, J.E.

    1991-01-01

    The advantages of using electric propulsion for propulsion are well-known in the aerospace community. The high specific impulse, lower propellant requirements, and lower system mass make it a very attractive propulsion option for the Space Exploration Initiative (SEI), especially for the transport of cargo. One such propulsion system is the PEGASUS Drive (Coomes et al. 1987). In its original configuration, the PEGASUS Drive consisted of a 10-MWe power source coupled to a 6-MW magnetoplasmadynamic (MPD) thruster system. The PEGASUS Drive propelled a manned vechicle to Mars and back in 601 days. By removing the crew and their associated support systems from the space craft and by incorporating technology advances in reactor design and heat rejection systems, a second generation PEGASUS Drive can be developed with an alpha less than two. Utilizing this propulsion system, a 400-MT cargo vechicle, assembled and loaded in low Earth orbit (LEO), could deliver 262 MT of supplies and hardware to MARS 282 days after escaping Earth orbit. Upon arrival at Mars the transport vehicle would place its cargo in the desired parking orbit around Mars and then proceed to synchronous orbit above the desired landing sight. Using a laser transmitter, PEGASUS could provide 2-MW on the surface to operate automated systems deployed earlier and then provide surface power to support crew activities after their arrival. The additional supplies and hardware, coupled with the availability of megawatt levels of electric power on the Mars surface, would greatly enhance and even expand the mission options being considered under SEI

  15. Personnel dosimetry methods introduced in the Czechoslovak national laboratories

    International Nuclear Information System (INIS)

    Trousil, J.; Singer, J.; Kokta, L.; Prouza, Z.

    1979-01-01

    Personnel dosimetry methods are described that were developed in the Institute for Research, Production and Application of Radioisotopes and that have been or will be introduced in the national personnel dosimetry service. In Czechoslovakia, workers exposed to a radiation risk are divided into two groups, according to the level of the risk. The criterion is the possibility of exceeding one tenth of the MPD. For the higher risk group, a complex dose meter is usually used for dosimetry of photon and beta radiation; it contains a film dose meter and a radiothermoluminescent (RTL) glass dose meter. The RTL glass dose meter also serves as an accident dose meter. For neutron dosimetry, a dose meter comprising a solid-state track detector in combination with fissionable foils has been introduced. For accident dosimetry, a silicon diode of Czechoslovak production is used. For the lower risk group, only the introduction of an RTL dose meter is foreseen. There will be a three month control period; for neutron dosimetry, the track detector in combination with fissionable foils is retained. For measurements of hand doses, a themoluminescent ring dose meter has been introduced. The dose meters are described, giving information on the types of detectors employed, measurement techniques and descriptions of the basic characteristics of the instruments, their basic dosimetric parameters and the dose and energy ranges which can be measured. The results of international comparisons are presented; these have served to confirm the measurement precision. In conclusion, some questions of dose-meter calibration are summarized, and the problems of dose measurement in mixed fields of neutrons and gamma rays are discussed. (author)

  16. Vitamin K epoxide reductase complex subunit 1 (Vkorc1 haplotype diversity in mouse priority strains

    Directory of Open Access Journals (Sweden)

    Kohn Michael H

    2008-12-01

    Full Text Available Abstract Background Polymorphisms in the vitamin K-epoxide reductase complex subunit 1 gene, Vkorc1, could affect blood coagulation and other vitamin K-dependent proteins, such as osteocalcin (bone Gla protein, BGP. Here we sequenced the Vkorc1 gene in 40 mouse priority strains. We analyzed Vkorc1 haplotypes with respect to prothrombin time (PT and bone mineral density and composition (BMD and BMC; phenotypes expected to be vitamin K-dependent and represented by data in the Mouse Phenome Database (MPD. Findings In the commonly used laboratory strains of Mus musculus domesticus we identified only four haplotypes differing in the intron or 5' region sequence of the Vkorc1. Six haplotypes differing by coding and non-coding polymorphisms were identified in the other subspecies of Mus. We detected no significant association of Vkorc1 haplotypes with PT, BMD and BMC within each subspecies of Mus. Vkorc1 haplotype sequences divergence between subspecies was associated with PT, BMD and BMC. Conclusion Phenotypic variation in PT, BMD and BMC within subspecies of Mus, while substantial, appears to be dominated by genetic variation in genes other than the Vkorc1. This was particularly evident for M. m. domesticus, where a single haplotype was observed in conjunction with virtually the entire range of PT, BMD and BMC values of all 5 subspecies of Mus included in this study. Differences in these phenotypes between subspecies also should not be attributed to Vkorc1 variants, but should be viewed as a result of genome wide genetic divergence.

  17. Production of bio-gas from maize cobs

    Energy Technology Data Exchange (ETDEWEB)

    Leke, Luter [College of Physical Sciences, University of Aberdeen, AB24 3UE, Aberdeen (United Kingdom); Department of Chemistry, Benue State University, P M B 102119, Makurdi (Nigeria); Ogbanje, Anne Ada [Department of Chemistry, Benue State University, P M B 102119, Makurdi (Nigeria); Department of Renewable Energy, Energy Commission of Nigeria, Garki-Abuja (Nigeria); Terfa, Dekaa Henry [Department of Chemistry, Benue State University, P M B 102119, Makurdi (Nigeria); Ikyaagba, Tyoalumun [College of Physical Sciences, University of Aberdeen, AB24 3UE, Aberdeen (United Kingdom)

    2013-07-01

    Anaerobic digestion of energy crop residues and wastes is of increasing interest in order to reduce greenhouse gas emissions and to facilitate a sustainable development of energy supply. Production of biogas provides a versatile carrier of renewable energy, as methane can be used for replacement of fossil fuels in both heat and power generation as vehicle fuel. Biogas fuel production from blends of biological wastes such as Cow rumen liquor (CL), Poultry droppings (PD), and Goat Faeces (GF) with Maize cobs (M) were studied. 20 g of each inoculum was mixed with 100g of degraded maize cobs in the first three digesters while the fourth contained CL 10g, PD 10 g, and M 100 g. 100 g of M alone in the fifth digester served as the control. The blends were subjected to anaerobic digestion for 10 days on the prevailing atmospheric ambient temperature and pressure conditions. Physiochemical properties of the blends such as moisture content, crude protein, ash, fat, crude fibre, carbohydrate content, C/N ratio, and pH were also determined. Results of the daily performances of each system showed that maize cobs (M) alone had cumulative biogas yield of 1.50 cm3 while those of the blends (MCL, MPD, MGF and MCLPD) were 6.11 cm3, 3.05 cm3, 2.50 cm3, and 63.00 cm3 respectively, pH and C/N ratio affected the biogas yield of the systems significantly. These results indicate that the low biogas production from maize cobs can be enhanced significantly by blending with cow rumen liquor and poultry droppings.

  18. Recent selected theory developments for NICA

    Science.gov (United States)

    Blaschke, David

    2017-03-01

    In this contribution I present a few selected topics of recent theoretical developments of relevance for the NICA facility under construction. In a first part, I discuss new aspects of the QCD phase diagram like the possible existence of a critical endpoint of first-order phase transitions from the perspective of generalizations of the 3-flavor PNJL model including the conjecture of a universal pressure for the onset of deconfinement in heavy-ion collisions and astrophysics. A second part is devoted to first results of the newly constructed event simulator (THESEUS) which is based on the particlization of the former three-fluid hydrodynamics code by Ivanov, Russkikh and Toneev that allows also to study the role of hadronic final state interactions. Possible signals of the mixed phase accessible at NICA are considered. In particular, the robustness of the baryon-stopping signal of deconfinement and the occurrence of antiflow for protons have been investigated for Au+Au collisions in the range of the NICA-MPD energy scan for √s 6…8 GeV. This signal is reflected also in the flow pattern of light nuclear clusters, in particular deuterons. The sharp peak for the K+/π+ ratio at √s 8 GeV (the "horn" effect) is not obtained in the present version of THESEUS and calls for improvement of the equation of state input. I report the recent progress in developing a generalized Beth-Uhlenbeck approach to a unified description of quark-hadron matter which includes now strangeness and reveals a new mechanism for explaining the K+/π+ ratio due to the pronounced occurrence of an anomalous mode in the K+ at finite baryochemical potentials.

  19. Recent selected theory developments for NICA

    Directory of Open Access Journals (Sweden)

    Blaschke David

    2017-01-01

    Full Text Available In this contribution I present a few selected topics of recent theoretical developments of relevance for the NICA facility under construction. In a first part, I discuss new aspects of the QCD phase diagram like the possible existence of a critical endpoint of first-order phase transitions from the perspective of generalizations of the 3-flavor PNJL model including the conjecture of a universal pressure for the onset of deconfinement in heavy-ion collisions and astrophysics. A second part is devoted to first results of the newly constructed event simulator (THESEUS which is based on the particlization of the former three-fluid hydrodynamics code by Ivanov, Russkikh and Toneev that allows also to study the role of hadronic final state interactions. Possible signals of the mixed phase accessible at NICA are considered. In particular, the robustness of the baryon-stopping signal of deconfinement and the occurrence of antiflow for protons have been investigated for Au+Au collisions in the range of the NICA-MPD energy scan for √s ~ 6…8 GeV. This signal is reflected also in the flow pattern of light nuclear clusters, in particular deuterons. The sharp peak for the K+/π+ ratio at √s ~ 8 GeV (the “horn” effect is not obtained in the present version of THESEUS and calls for improvement of the equation of state input. I report the recent progress in developing a generalized Beth-Uhlenbeck approach to a unified description of quark-hadron matter which includes now strangeness and reveals a new mechanism for explaining the K+/π+ ratio due to the pronounced occurrence of an anomalous mode in the K+ at finite baryochemical potentials.

  20. Preparation of Ni-Fe bimetallic porous anode support for solid oxide fuel cells using LaGaO{sub 3} based electrolyte film with high power density

    Energy Technology Data Exchange (ETDEWEB)

    Ju, Young-Wan; Ida, Shintaro; Ishihara, Tatsumi [Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Motooka 744, Nishi-Ku, Fukuoka 819-0395 (Japan); Eto, Hiroyuki [Mitsubishi Materials Corporation, Central Research Institute, 1002-14 Mukohyama, Naka-Shi, Ibaraki 311-0102 (Japan); Inagaki, Toru [The Kansai Electric Power Co., Inc., 11-20 Nakoji 3-Chome, Amagasaki, Hyogo 661-0974 (Japan)

    2010-10-01

    Optimization of sintering temperature for NiO-Fe{sub 2}O{sub 3} composite oxide substrate was studied in order to obtain a dense substrate with smooth surface. By in situ reduction, the substrate was changed to a porous Ni-Fe alloy metal. The volumetric shrinkage and porosity of the substrate were also studied systematically with the Ni-Fe substrate reduced at different temperatures. A Sr and Mg-doped LaGaO{sub 3} (LSGM) thin film was prepared on dense substrate by the pulsed laser deposition (PLD) method. The LSGM film with stoichiometric composition was successfully prepared under optimal deposition parameters and a target composition. Sm{sub 0.5}Sr{sub 0.5}CoO{sub 3} (SSC55) cathode was prepared by the slurry coating method on the deposited film. Prepared SOFC single cell shows high power density and the maximum power density (MPD) achieved was 1.79, 0.82 and 0.29 W cm{sup -2} at 973, 873 and 773 K, respectively. After thermal cycle from 973 to 298 K, the cell shows almost theoretical open circuit potential (1.1 V) and the power density of 1.62 W cm{sup -2}, which is almost the same as that at first cycles. Therefore, the Ni-Fe porous metal support made by the selective reduction is highly promising as a metal anode substrate for SOFC using LaGaO{sub 3} thin film. (author)

  1. Thin Film Nanocomposite Membrane Filled with Metal-Organic Frameworks UiO-66 and MIL-125 Nanoparticles for Water Desalination

    Directory of Open Access Journals (Sweden)

    Mohammed Kadhom

    2017-06-01

    Full Text Available Knowing that the world is facing a shortage of fresh water, desalination, in its different forms including reverse osmosis, represents a practical approach to produce potable water from a saline source. In this report, two kinds of Metal-Organic Frameworks (MOFs nanoparticles (NPs, UiO-66 (~100 nm and MIL-125 (~100 nm, were embedded separately into thin-film composite membranes in different weight ratios, 0%, 0.05%, 0.1%, 0.15%, 0.2%, and 0.3%. The membranes were synthesized by the interfacial polymerization (IP of m-phenylenediamine (MPD in aqueous solution and trimesoyl chloride (TMC in an organic phase. The as-prepared membranes were characterized by scanning electron microscopy (SEM, transmission electron microscopy (TEM, contact angle measurement, attenuated total reflection Fourier transform infrared (ATR FT-IR spectroscopy, and salt rejection and water flux assessments. Results showed that both UiO-66 and MIL-125 could improve the membranes’ performance and the impacts depended on the NPs loading. At the optimum NPs loadings, 0.15% for UiO-66 and 0.3% for MIL-125, the water flux increased from 62.5 L/m2 h to 74.9 and 85.0 L/m2 h, respectively. NaCl rejection was not significantly affected (UiO-66 or slightly improved (MIL-125 by embedding these NPs, always at >98.5% as tested at 2000 ppm salt concentration and 300 psi transmembrane pressure. The results from this study demonstrate that it is promising to apply MOFs NPs to enhance the TFC membrane performance for desalination.

  2. Delivery quality assurance with ArcCHECK

    International Nuclear Information System (INIS)

    Neilson, Christopher; Klein, Michael; Barnett, Rob; Yartsev, Slav

    2013-01-01

    Radiation therapy requires delivery quality assurance (DQA) to ensure that treatment is accurate and closely follows the plan. We report our experience with the ArcCHECK phantom and investigate its potential optimization for the DQA process. One-hundred seventy DQA plans from 84 patients were studied. Plans were classified into 2 groups: those with the target situated on the diodes of the ArcCHECK (D plans) and those with the target situated at the center (C plans). Gamma pass rates for 8 target sites were examined. The parameters used to analyze the data included 3%/3 mm with the Van Dyk percent difference criteria (VD) on, 3%/3 mm with the VD off, 2%/2 mm with the VD on, and x/3 mm with the VD on and the percentage dosimetric agreement “x” for diode plans adjusted. D plans typically displayed maximum planned dose (MPD) on the cylindrical surface containing ArcCHECK diodes than center plans, resulting in inflated gamma pass rates. When this was taken into account by adjusting the percentage dosimetric agreement, C plans outperformed D plans by an average of 3.5%. ArcCHECK can streamline the DQA process, consuming less time and resources than radiographic films. It is unnecessary to generate 2 DQA plans for each patient; a single center plan will suffice. Six of 8 target sites consistently displayed pass rates well within our acceptance criteria; the lesser performance of head and neck and spinal sites can be attributed to marginally lower doses and increased high gradient of plans

  3. Intermetallic Competition in the Fragmentation of Trimetallic Au-Zn-Alkali Complexes.

    Science.gov (United States)

    Lang, Johannes; Cayir, Merve; Walg, Simon P; Di Martino-Fumo, Patrick; Thiel, Werner R; Niedner-Schatteburg, Gereon

    2016-02-12

    Cationization is a valuable tool to enable mass spectrometric studies on neutral transition-metal complexes (e.g., homogenous catalysts). However, knowledge of potential impacts on the molecular structure and catalytic reactivity induced by the cationization is indispensable to extract information about the neutral complex. In this study, we cationize a bimetallic complex [AuZnCl3 ] with alkali metal ions (M(+) ) and investigate the charged adducts [AuZnCl3 M](+) by electrospray ionization mass spectrometry (ESI-MS). Infrared multiple photon dissociation (IR-MPD) in combination with density functional theory (DFT) calculations reveal a μ(3) binding motif of all alkali ions to the three chlorido ligands. The cationization induces a reorientation of the organic backbone. Collision-induced dissociation (CID) studies reveal switches of fragmentation channels by the alkali ion and by the CID amplitude. The Li(+) and Na(+) adducts prefer the sole loss of ZnCl2 , whereas the K(+) , Rb(+) , and Cs(+) adducts preferably split off MCl2 ZnCl. Calculated energetics along the fragmentation coordinate profiles allow us to interpret the experimental findings to a level of subtle details. The Zn(2+) cation wins the competition for the nitrogen coordination sites against K(+) , Rb(+) , and Cs(+) , but it loses against Li(+) and Na(+) in a remarkable deviation from a naive hard and soft acids and bases (HSAB) concept. The computations indicate expulsion of MCl2 ZnCl rather than of MCl and ZnCl2 . © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Geotechnical aspects of subseabed disposal of high level radioactive wastes

    International Nuclear Information System (INIS)

    Silva, A.J.; Calnan, D.I.

    1981-01-01

    Additional data on geotechnical properties of MPG-1 sediments are presented. New data on Distal Abyssal Plain sediments east of the North Bermuda Rise (MPG-3N) indicates that this region has characteristics which compare favorably with MPG-1. The new permeability results are consistent with previous reported results for MPG-1 with a coefficient of permeability of approximately 10 -7 cm/sec. Preliminary results from MPG-3N indicate permeabilities comparable with those of MPG-1. Results are presented for thirty-seven triaxial compression tests on both undisturbed and remolded illite and smectite clays from the North Central Pacific (MPG-1). A preliminary set of repeated loading triaxial compression tests were performed on illite and smectite remolded clays from MPD-1. A device for anisotropic consolidation and triaxial compression has been developed which will allow the study of stress-strain behavior after anisotropic consolidation with zero lateral deformation. The long-term stress-strain behavior of deep sea sediments is the focus of a two-part testing program: Phase 1; room temperature studies, will be completed in Spring, 1980 and Phase 2; temperature effect studies, is now in the equipment development stage and should be underway by June, 1980. The testing portion of the laboratory Hole Closure study has been completed and most of the results are reported. A final technical report will be completed in June, 1980. The involvement of URI/MGL in this project covers five areas: site characterization, geotechnical analysis for platform foundation configuration, laboratory analysis of sediment-structure interaction development of in-situ vane shear apparatus and post-test analysis of recovered data relating to geotechnical behavior

  5. New instruments and methods for measuring the concentration of radioactive products in the atmosphere; Appareils recents et methodes nouvelles pour la mesure de la concentration des produits radioactifs dans l'atmosphere

    Energy Technology Data Exchange (ETDEWEB)

    Jehanno, C; Blanc, A; Lallemant, C; Roux, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1959-07-01

    Different recorders for radioactive aerosols have been developed for measuring the pollution of the atmosphere in laboratories or the external atmosphere. EAR 600. - Allows continuous measurement, instantaneously and 3 to 10 hours after sampling, of concentrations of {alpha} or {beta} emitting aerosols varying between some 10{sup -11} and some 10{sup -8} curie per cubic metre of air. EAR 800. - Allows continuous measurement of concentration of {alpha} emitting aerosols varying between 10{sup -11} and 10{sup -5} curie per cubic metre of air and concentration of {beta} emitting aerosols from 10{sup -11} to 10{sup -1} curie per cubic metre of air. EAR Plutonium. - Allows detection after several minutes of 1000 MPD (2 x 10{sup -9} curie par cubic metre), and after 8 hours 1 MPD (2 x 10{sup -12} curie per cubic metre). Two methods are used to separate the activity due to plutonium from that due to the descendants of radon and thoron: a) by amplitude discrimination, b) by RaC-RaC' and ThC-ThC' ({alpha} {beta} ) coincidences. SP4. This system, mounted on a jeep, allows the measurement of irradiation produced on the ground by the smoke from the piles. The sensitivity is 5{mu}R/h. A.D.I.R. - This autonomous and portable instrument is designed for the instantaneous measurement of the radon content of the atmosphere in mines. It allows the measurement of contents in air varying between 0.4 and 400 x 10{sup -10} curie per litre of air (0.4 and 400 MPD). The measurement of radioactive fall-out is carried out after collection of this activity by a special rain gauge which comprises an adhesive surface and a tube containing ion exchange resins. The radioactivity of the fall-out varies between some 10{sup -9} and some 10{sup -7} curie per square metre per month. Concentrations in fission products of the atmosphere are measured after collecting on filter paper. Concentrations measured in air at ground level vary between 10{sup -13} and 10{sup -12} curie per cubic metre. (author

  6. A Generic Model for Prediction of Separation Performance of Olefin/Paraffin Mixture by Glassy Polymer Membranes

    Directory of Open Access Journals (Sweden)

    A.A. Ghoreyshi

    2008-02-01

    Full Text Available The separation of olefin/paraffin mixtures is an important process in petrochemical industries, which is traditionally performed by low temperature distillation with a high-energy consumption, or complex extractive distillationand adsorption techniques. Membrane separation process is emerging as an alternative for traditional separation processes with respect to low energy and simple operation. Investigations made by various researchers on polymeric membranes it is found that special glassy polymers render them as suitable materials for olefin/paraffin mixture separation. In this regard, having some knowledge on the possible transport mechanism of these processes would play a significant role in their design and applications. In this study, separation behavior of olefin/paraffin mixtures through glassy polymers was modeled by three different approaches: the so-called dual transport model, the basic adsorption-diffusion theory and the general Maxwell-Stefan formulation. The systems chosen to validate the developed transport models are separation of ethane-ethylene mixture by 6FDA-6FpDA polyimide membrane and propane-propylene mixture by 6FDA-TrMPD polyimide membrane for which the individual sorption and permeation data are available in the literature. Acritical examination of dual transport model shows that this model fails clearly to predict even the proper trend for selectivities. The adjustment of pemeabilities by accounting for the contribution of non-selective bulk flow in the transport model introduced no improvement in the predictability of the model. The modeling results based on the basic adsorption-diffusion theory revealed that in this approach only using mixed permeability data, an acceptable result is attainable which fades out the advantages of predictibility of multicomponent separation performance from pure component data. Finally, the results obtained from the model developed based on Maxwell-Stefan formulation approach show a

  7. Perlindungan Hukum Pemanggilan dan Pengambilan Minuta Akta Notaris Paska Berlakunya UU No. 2 Tahun 2014 Tentang Perubahan Atas UU No. 30 Tahun 2004 Tentang Jabatan Notaris (UUJN-P

    Directory of Open Access Journals (Sweden)

    Muhammad Rikaz Prabowo

    2016-02-01

    Full Text Available This paper discusses legal protection for Notaries-Function; in terms of the request upon the copies of the deed minuta, Notarial-deeds protocol, and the calling of Notaries-vocation in legal processes. The identification of the problemis to understand mechanisms of legal protections for Notaries and MKN’s roles and to discussnotaries’ refusal rights and refusal obligation. Based on the literature review and studies on the literatures and legal resources, it can be concluded that: First, the mechanisms of legal protection for request upon the copies of the minuta, the protocol takin of the notary, and the calling of notary for investigation purposes, by investigating-officers, public-prosecutors and judges- require approval of the Regional Supervisory Council as stated in Article 66 paragraph (1 Act Number 30 2004. In 2013 “the phrase of the MPD’s approval” is canceled by Constitutional Court through the decree number 49/PUU/X/2012 for not having legal binding. Second, the MKN is a new agency formed with the establishment of the Act Number 2 2014 concerning the amendment of the Act Number 30 2004 concerning Notaries’ functions (UUJN-P. One of MKN authorities was similar with authorities of the MPD before it was revoked by the MK in 2013. However, the MK had not been established because the Permenkumham on MKS was still being harmonized. Third, the Refusal-Rights are rights for not speaking and giving any statements related to deeds, as a witness in prosecutions and courts. These rights are based on Articles in the Acts, such as the KUHAP, KUH Perdata, HIR and the Act Number 5 1986 concerning state administrative law. The Act Number 30 Year 2004 concerning Notaries-functions (UUJN-P stipulates this provisions as refusal-obligations which mean that it must be executed imperatively, based on the Article 4 paragraph (2, the Article 16 paragraph (1 letter f, and the Article 54 clause (1. The violation of these obligations shall be the

  8. Evaluation of permanent I-125 prostate implants using radiography and magnetic resonance imaging

    International Nuclear Information System (INIS)

    Moerland, Marinus A.; Wijrdeman, Harm K.; Beersma, Robert; Bakker, Chris J.G.; Battermann, Jan J.

    1997-01-01

    Purpose: The aim of this study is the evaluation of permanent I-125 prostate implants using radiography and magnetic resonance imaging (MRI). Methods and Materials: Twenty-one patients underwent radiography on the simulator and MRI within 3 days after implantation of the I-125 seeds. Isocentric radiographs were used for reconstruction of the seed distribution, after which registration with the seed-induced signal voids on MRI provided the seed positions in relation to the prostate. The prostate was contoured on the transversal magnetic resonance images, and dose-volume histograms were computed to evaluate the implants. The validity of the ellipsoidal prostate volume approximation, as applied in preimplant dose calculation, was assessed by comparison of ellipsoidal volumes given by prostate width, height, and length and prostate volumes obtained by a slice-by-slice contouring method, both on postimplant MRI. Prostate volume changes due to postimplant prostate swelling were assessed from radiographs taken at 3 days and 1 month after the implantation. Results: The seeds were readily identified on T 1 -weighted spin-echo images and matched with the seed distribution reconstructed from the isocentric radiographs. The matching error, averaged over 21 patients, amounted to 1.8 ± 0.4 mm (mean ± standard deviation). The fractions of the prostate volumes receiving the prescribed matched peripheral dose (MPD) ranged from 32 to 71% (mean ± standard deviation: 60 ± 10%). Prostate volumes, obtained by the contouring method on postimplant MRI, were a factor 1.5 ± 0.3 larger than the ellipsoidal volumes given by the prostate dimensions on postimplant MRI. Prostate volumes 3 days after the implantation were a factor 1.3 ± 0.2 larger than the prostate volumes 1 month after the implantation. Registration of the reconstructed seed distribution and the MR images showed inaccuracies in seed placement, for example, two or more seeds clustering together or seeds outside the prostate

  9. Fabrication and electrochemical properties of cathode-supported solid oxide fuel cells via slurry spin coating

    International Nuclear Information System (INIS)

    Chen Min; Luo Jingli; Chuang, Karl T.; Sanger, Alan R.

    2012-01-01

    Highlights: ► LSM cathode-supported cell prepared by slurry spin coating. ► Optimizing porosity in CFL resulting in power density of 0.58 W cm −2 at 850 °C. ► Activation polarization govern the impedance arcs measured under the OCV condition. ► Concentration polarization can induce the change of activation polarization. ► Four kinds of polarizations of our cells are separated and investigated. - Abstract: A cathode-supported SOFC consisting of LSM (La 0.8 Sr 0.2 MnO 3−δ ) cathode supporter, LSM–Sm 0.2 Ce 0.8 O 2−δ (SDC) cathode functional layer (CFL), yttria stabilized zirconia (YSZ)/SDC bi-layered electrolyte and Ni-YSZ anode layer was fabricated by a slurry spin coating technique. The influence of the porosity in both the CFL and cathode supporter on the electrochemical properties of the cells has been investigated. It was found that properly controlling the porosity in the CFL would improve the performance of the cells using O 2 in the cathode side (O 2 -cells), with a maximum power density (MPD) value achieving as high as 0.58 W cm −2 at 850 °C. However, this improvement is not so evident for the cells using air in the cathode side (air-cells). When increasing the porosity in the cathode-supporter, a significant increase of the power density for the air cells due to the decreasing R conc,c (cathode concentration polarization to the cell resistance) can be ascertained. In terms of our analysis on various electrochemical parameters, the R act (activation polarization to the cell resistance) is assumed to be mainly responsible for the impedance arcs measured under the OCV condition, with a negligible R conc,c value being able to be detected in our impedances. In this case, a significant decreasing size of the impedance arcs due to the increasing porosity in the cathode supporter would correspond to a decrease of the R act values, which was proved to be induced by the decreasing R conc,c .

  10. A novel high performance composite anode with in situ growth of Fe-Ni alloy nanoparticles for intermediate solid oxide fuel cells

    International Nuclear Information System (INIS)

    Li, Jingcheng; Yu, Yan; Yin, Yi-Mei; Zhou, Ning; Ma, Zi-Feng

    2017-01-01

    Highlights: • A composite anode with endogenous Fe-Ni alloy nanoparticles has been prepared. • The redox reversibility of the anode has been confirmed by XRD. • The E_a of H_2 oxidation at the anode is much smaller than that at Ni-YSZ anode. • A ScSZ supported cell achieves MPD of 0.71 Wcm"−"2 and R_p of 0.16 Ω cm"2 at 800 °C. • The single cell shows stable output during 105 h testing at 800 °C 0.7 V in wet H_2". - Abstract: A redox reversible composite anode with Fe-Ni alloy nanoparticles in situ growth on SrLaFeO_4-type and LaFeO_3-type oxide substrates has been prepared for intermediate temperature solid oxide fuel cell (IT-SOFC) by reducing perovskite precursor La_0_._4Sr_0_._6Fe_0_._7_5Ni_0_._1Nb_0_._1_5O_3_-_δ (LSFNNb) in wet H_2 at 900 °C for 1 h. The anode has shown an excellent electrochemical catalytic activity for oxidation of hydrogen with much smaller E_a (25.1 ∼ 68.9 kJ mol"−"1) than the value (>160 kJ mol"−"1) at Ni-YSZ anode. A scandium stabilized zirconia (ScSZ) electrolyte supported SOFC with the anode achieves maximum power densities of 0.71, 0.52, 0.35, and 0.21 W cm"−"2 at 800, 750, 700 and 650 °C, respectively in wet H_2 (3% H_2O), and the corresponding R_p of 0.16, 0.21, 0.35, and 0.60 Ω cm"2 under OCV. Moreover, the single cell shows stable power output during ∼105 h operation at 800 °C under 0.7 V in wet H_2 after a initial degradation, indicating that R-LSFNNb is an excellent candidate as anode of IT-SOFC.

  11. Validation of a predictive model describing growth of Salmonella in enteral feeds Validação de um modelo preditivo para descrever o crescimento de Salmonella em dietas enterais

    Directory of Open Access Journals (Sweden)

    Roberta Ribeiro Silva

    2009-03-01

    Full Text Available The growth of Salmonella enterica subs. enterica sorovar Typhimurium at 25°C was monitored in industrialized and hospital formulated enteral feeds and the results were used to validate the mathematical model of Salmonella growth presented by the Pathogen Modeling Program (PMP 7.0 (USDA-USA. The generation time of Salmonella in enteral feeds ranged from 21 to 34.8 min and, the maximum growth rate (µmax varied from 1.28 to 1.95 h-1, resulting in a population increase from 5 to 6 log10 cycles within 14 to 24 h incubation. Growth was faster in the hospital formulated feed containing vegetables and eggs. The growth kinetic's parameters as lag phase; µmax and maximum population density (MPD were similar to those predicted by the PMP 7.0, with exception of lag phase in enteral diet at pH 6.3. The results of this study validated the PMP 7.0 model for describe Salmonella growth in enteral feeds and demonstrates the appropriateness of use such model to determine the pathogen behavior in a wide range of storage conditions in this food.O crescimento de Salmonella enterica subs. enterica sorovar Typhimurium a 25°C foi determinado em dietas enterais industrializadas e formuladas em hospital e os resultados obtidos foram usados para validar um modelo matemático de crescimento de Salmonella apresentado no Programa de Modelagem de Patógenos (PMP, versão 7,0 (USDA-EUA. O tempo de geração de Salmonella em dietas enterais variou de 21 a 34,8 min e a velocidade específica máxima de crescimento (µmax foi de 1,28 a 1,95 h-1, resultando em aumento de 5 a 6 ciclos logarítimos em um período de 14 a 24 h de incubação. O crescimento foi mais rápido na dieta formulada em hospital contendo vegetais e ovos. Os parâmetros cinéticos como fase lag, µmax e densidade populacional máxima (MDP foram similares aqueles previstos no PMP 7.0, com exceção da fase lag em dietas enteral com pH 6,3. Os resultados deste estudo validaram o modelo do PMP 7,0 para

  12. Prevalence and factors associated with minor psychiatric disorders in hospital housekeeping workers.

    Science.gov (United States)

    Marconato, Cintia da Silva; Magnago, Ana Carolina de Souza; Magnago, Tânia Solange Bosi de Souza; Dalmolin, Graziele de Lima; Andolhe, Rafaela; Tavares, Juliana Petri

    2017-06-12

    Investigating the prevalence and factors associated with minor psychiatric disorders (MPDs) in Hospital housekeeping workers. A cross-sectional study carried out in 2013 with workers from the cleaning service of a public university hospital in Rio Grande do Sul, Brazil. Data were collected through a form containing sociodemographic, occupational, habits and health variables. The Self-Reporting Questionnaire-20 was used in order to evaluate MPDs. The study population consisted of 161 workers. The overall prevalence of suspected MPD was 29.3%. The chances of suspected MPDs were higher in workers with Effort-Reward Imbalance, those who did not have time or who occasionally had time for leisure activities, and those taking medications. The prevalence of MPDs was similar to that found in the literature for health workers. Therefore, we consider it important to include these workers in institutional programs for continuing health education. Investigar a prevalência e os fatores associados aos Distúrbios Psíquicos Menores (DPMs) em trabalhadores do Serviço Hospitalar de Limpeza. Estudo transversal, realizado em 2013, com trabalhadores do serviço de limpeza de um hospital universitário público do Rio Grande do Sul, Brasil. Os dados foram coletados por meio de um formulário contendo variáveis sociodemográficas, laborais, hábitos e saúde. Para avaliação dos DPMs utilizou-se do Self-Reporting Questionnaire-20. A população do estudo foi composta pelos 161 trabalhadores. A prevalência global para suspeição de DPM foi de 29,3%. As chances de suspeição de DPMs foram maiores nos trabalhadores em Desequilíbrio Esforço-Recompensa, nos que não tinham ou às vezes tinham tempo para o lazer e naqueles que faziam uso de medicação. A prevalência de DPMs assemelhou-se à encontrada na literatura em trabalhadores da área saúde. Portanto, considera-se importante a inclusão desses trabalhadores em programas institucionais de educação permanente em saúde.

  13. Testing the Efficacy of DNA Barcodes for Identifying the Vascular Plants of Canada.

    Science.gov (United States)

    Braukmann, Thomas W A; Kuzmina, Maria L; Sills, Jesse; Zakharov, Evgeny V; Hebert, Paul D N

    2017-01-01

    Their relatively slow rates of molecular evolution, as well as frequent exposure to hybridization and introgression, often make it difficult to discriminate species of vascular plants with the standard barcode markers (rbcL, matK, ITS2). Previous studies have examined these constraints in narrow geographic or taxonomic contexts, but the present investigation expands analysis to consider the performance of these gene regions in discriminating the species in local floras at sites across Canada. To test identification success, we employed a DNA barcode reference library with sequence records for 96% of the 5108 vascular plant species known from Canada, but coverage varied from 94% for rbcL to 60% for ITS2 and 39% for matK. Using plant lists from 27 national parks and one scientific reserve, we tested the efficacy of DNA barcodes in identifying the plants in simulated species assemblages from six biogeographic regions of Canada using BLAST and mothur. Mean pairwise distance (MPD) and mean nearest taxon distance (MNTD) were strong predictors of barcode performance for different plant families and genera, and both metrics supported ITS2 as possessing the highest genetic diversity. All three genes performed strongly in assigning the taxa present in local floras to the correct genus with values ranging from 91% for rbcL to 97% for ITS2 and 98% for matK. However, matK delivered the highest species discrimination (~81%) followed by ITS2 (~72%) and rbcL (~44%). Despite the low number of plant taxa in the Canadian Arctic, DNA barcodes had the least success in discriminating species from this biogeographic region with resolution ranging from 36% with rbcL to 69% with matK. Species resolution was higher in the other settings, peaking in the Woodland region at 52% for rbcL and 87% for matK. Our results indicate that DNA barcoding is very effective in identifying Canadian plants to a genus, and that it performs well in discriminating species in regions where floristic diversity is

  14. Design and implementation of wormlike creeping mobile robot for EAST remote maintenance system

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Qiang, E-mail: zhangqiang@iim.ac.cn [Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui 230031 (China); Department of Automation, University of Science and Technology of China, Hefei, Anhui 230026 (China); Zhou, Ling [Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui 230031 (China); Wang, Zengfu, E-mail: zfwang@ustc.edu.cn [Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui 230031 (China); Department of Automation, University of Science and Technology of China, Hefei, Anhui 230026 (China)

    2017-05-15

    Highlights: • Wormlike creeping robot walking on the V-shaped circular slot in EAST fusion vessel. • Mobile platform to carry equipments or assist manipulators for maintenance tasks. • Chain structure design with n(n ≥ 2) creeping units each of which has three segments. • Creeping gait planning to construct a multi-axis coordinating control scheme. • Evaluation and verification of basic motion performance and mechanical properties. - Abstract: Maintenance for nuclear fusion vessel is crucial, yet it faces great difficulty due to the complex internal physical and geometric conditions. Since the limitation on inherent strength, load, size, etc, a manipulator robot can only complete very limited tasks. Robotic arm systems for remote operation such as JET and MPD can carry certain tools to complete a variety of operating tasks, but it is difficult to achieve the system which is very complex. Therefore, if the inherent idea of using a single robot to complete the specified functions can change, it is possible to make the problems simpler and easier to solve by adding auxiliary robots working together with the robotic arm systems to complete the assigned tasks. Under the above background, based on the deeply analyzing and refining the functional requirements of the vessel operation robot, proceeding from the perspective of ability to move and carry a certain operating device, this paper presents a wormlike creeping mobile robot walking on the V-shaped circular slot inside a nuclear fusion vessel such as EAST (Experimental Advanced Superconducting Tokamak). We have designed and implemented the principle prototype of the robot which has chain structure with n (n ≥2) creeping units. Each creeping unit is of three-part structure, which consists of fore segment, mid segment and back segment connected by bidirectional universal joint. The fore and back segments stretch the paws to contact the surface of V-shaped slot, while the mid segment realizes the overall

  15. Pancreatic cancer in patients with chronic calcifying pancreatitis: Computed tomography findings – a retrospective analysis of 48 patients

    Energy Technology Data Exchange (ETDEWEB)

    Mohamed, Amir, E-mail: amir.med87@gmail.com [Department of Radiology, Brabois Adults Hospital, Nancy (France); Ayav, Ahmet [Department of HPB Surgery, University Hospital of Nancy (France); Belle, Arthur [Department of Hepatogastroenterologie, Brabois Adults Hospital, Nancy (France); Orry, Xavier [Department of Radiology, Brabois Adults Hospital, Nancy (France); Chevaux, Jean-Baptiste [Department of Hepatogastroenterologie, Brabois Adults Hospital, Unité Inserm U954, Nancy (France); Laurent, Valerie [Department of Radiology, Brabois Adults Hospital, Nancy (France); Laboratory IADI, INSERM u947 (France)

    2017-01-15

    Objective: Chronic calcifying pancreatitis (CCP) is a risk factor for pancreatic cancer (PC). Symptoms of PC are non-specific in patients with CCP, and diagnostic imaging can be difficult. Some studies have shown that diagnosis may take several months, leading to delays in treatment (Lin et al., 2015; Lennon et al., 2014) . The aim of this study was to describe the radiological signs of PC in patients with CCP. Methods: This retrospective, single-center study was conducted between January 2004 and December 2014. Patients with CCP who were being monitored for PC were included. Each patient diagnosed with PC was matched with two CCP controls who did not develop PC. Results: We studied 48 patients with CCP (30 men (62%) and 18 women (38%), mean age 69.4 years). Sixteen patients (with 18 tumor sites) who developed PC (1.52%) were compared with 32 controls who did not develop PC. A hypodense mass was observed in all of the patients with PC, predominantly in the pancreatic head (61.2%). No such masses were observed in the controls (p < 0.001). The average mass size was 36.3 mm, and the masses were observed to push aside the calcifications in all patients (p < 0.001). Calcifications were very abundant (>10) in 33.3% of the patients with PC and in 71.9% of the controls (p = 0.0076). The main pancreatic duct (MPD) was dilated in all of the patients with PC (average diameter 8.6 mm; homogeneous in 83.3%) and in only 46.9% of the controls (average 7.4 mm; homogeneous in 37.5%) (p > 0.05). Dilation of the intrahepatic bile ducts and common bile duct was observed in 15 (94.4%) of the patients with PC and in none of the controls (p < 0.0001). The average alcohol consumption was 1 g/day (0–5 g/day) in the PC group and 4.6 g/day (0–20 g/day) in the control group. In addition, the average smoking history was 14.25 pack-years (0–40 PY) in the PC group and 27.70 PY (0–60 PY) in the control group. Conclusion: The presence of a pancreatic mass in a patient with CCP is

  16. Ligand-protected gold clusters: the structure, synthesis and applications

    International Nuclear Information System (INIS)

    Pichugina, D A; Kuz'menko, N E; Shestakov, A F

    2015-01-01

    Modern concepts of the structure and properties of atomic gold clusters protected by thiolate, selenolate, phosphine and phenylacetylene ligands are analyzed. Within the framework of the superatom theory, the 'divide and protect' approach and the structure rule, the stability and composition of a cluster are determined by the structure of the cluster core, the type of ligands and the total number of valence electrons. Methods of selective synthesis of gold clusters in solution and on the surface of inorganic composites based, in particular, on the reaction of Au n with RS, RSe, PhC≡C, Hal ligands or functional groups of proteins, on stabilization of clusters in cavities of the α-, β and γ-cyclodextrin molecules (Au 15 and Au 25 ) and on anchorage to a support surface (Au 25 /SiO 2 , Au 20 /C, Au 10 /FeO x ) are reviewed. Problems in this field are also discussed. Among the methods for cluster structure prediction, particular attention is given to the theoretical approaches based on the density functional theory (DFT). The structures of a number of synthesized clusters are described using the results obtained by X-ray diffraction analysis and DFT calculations. A possible mechanism of formation of the SR(AuSR) n 'staple' units in the cluster shell is proposed. The structure and properties of bimetallic clusters M x Au n L m (M=Pd, Pt, Ag, Cu) are discussed. The Pd or Pt atom is located at the centre of the cluster, whereas Ag and Cu atoms form bimetallic compounds in which the heteroatom is located on the surface of the cluster core or in the 'staple' units. The optical properties, fluorescence and luminescence of ligand-protected gold clusters originate from the quantum effects of the Au atoms in the cluster core and in the oligomeric SR(AuSR) x units in the cluster shell. Homogeneous and heterogeneous reactions catalyzed by atomic gold clusters are discussed in the context of the reaction mechanism and the nature of the active

  17. Examination of health status of population from Uranium contaminated regions

    International Nuclear Information System (INIS)

    Milacic, S.; Jovicic, D.; Pantelic, G.; Kovacevic, R.; Pavlovic, M.; Tanaskovic, I.

    2002-01-01

    Uranium is widely distributed in the natural environment: in the soil, air and food. And thus all people on the planet inhale or ingest small quantities of uranium every day. However, depleted uranium (DU) is industrial product. It is used in medicine, aviation, astronomy, oil exploitation, as well as for military purposes for penetrating ammunition. America is not the only country that applies depleted uranium ammunition. It is a part of the military arsenal in France, England, Turkey, Israel, Russia, Saudi Arabia, Pakistan and Thailand. Depleted uranium is toxic for both humans and animals for two basic reasons: as a heavy metal, it has toxic chemical effects, and as an alpha-emitter, it also has radioactive effects. Although it is considered less radioactive than natural uranium, its toxicity is high due to high LET (linear energetic transfer) irradiation, tissue deposition (bones, kidneys, blood, lungs) and elimination time (5000 days). Radiation limit above which adverse health effects are initiated (radiation carcinogenic risk), depends on the quantity and contamination time (how much and how long), including also other factors, such as age, sex, previous health status, exposure to other materials, genetic predisposition and radiosensitivity (lack of indicators), diet and stress. According to ICRP recommendations, carcinogenic risk for the occupationally exposed individuals is minimal if the exposure is limited to the effective dose of 100 mSv for five years and not above 50 in a single year, being five times lower for general population. In average annual effective dose per population, from all sources is below 1mSv, carcinogenic risk will range from 1 per 10 000 to 1 per 100 000, and in occupationally exposed individuals exposed to maximum permitted doses (MPD), the risk of cancer with fatal outcome is below 3 per 100 000). Immediate effects of population exposure to low uranium doses do not result in evident clinical picture. Late consequences include

  18. Stat5 Exerts Distinct, Vital Functions in the Cytoplasm and Nucleus of Bcr-Abl+ K562 and Jak2(V617F)+ HEL Leukemia Cells

    International Nuclear Information System (INIS)

    Weber, Axel; Borghouts, Corina; Brendel, Christian; Moriggl, Richard; Delis, Natalia; Brill, Boris; Vafaizadeh, Vida; Groner, Bernd

    2015-01-01

    Signal transducers and activators of transcription (Stats) play central roles in the conversion of extracellular signals, e.g., cytokines, hormones and growth factors, into tissue and cell type specific gene expression patterns. In normal cells, their signaling potential is strictly limited in extent and duration. The persistent activation of Stat3 or Stat5 is found in many hum