WorldWideScience

Sample records for mp-sir events tab

  1. Sawtooth events and O+ in the plasma sheet and boundary layer: CME- and SIR-driven events

    Science.gov (United States)

    Lund, E. J.; Nowrouzi, N.; Kistler, L. M.; Cai, X.; Liao, J.

    2017-12-01

    The role of ionospheric ions in sawtooth events is an open question. Simulations[1,2,3] suggest that O+ from the ionosphere produces a feedback mechanism for driving sawtooth events. However, observational evidence[4,5] suggest that the presence of O+ in the plasma sheet is neither necessary nor sufficient. In this study we investigate whether the solar wind driver of the geomagnetic storm has an effect on the result. Building on an earlier study[4] that used events for which Cluster data is available in the plasma sheet and boundary layer, we perform a superposed epoch analysis for coronal mass ejection (CME) driven storms and streaming interaction region (SIR) driven storms separately, to investigate the hypothesis that ionospheric O+ is an important contributor for CME-driven storms but not SIR-driven storms[2]. [1]O. J. Brambles et al. (2011), Science 332, 1183.[2]O. J. Brambles et al. (2013), JGR 118, 6026.[3]R. H. Varney et al. (2016), JGR 121, 9688.[4]J. Liao et al. (2014), JGR 119, 1572.[5]E. J. Lund et al. (2017), JGR, submitted.

  2. MP-Division health and safety reference handbook

    International Nuclear Information System (INIS)

    Putnam, T.M.

    1987-09-01

    This report presents the objectives, organization, policies, and essential rules and procedures that have been adopted by MP Division and that form the basis of the Health and Safety Program of the Clinton P. Anderson Meson Physics Facility (LAMPF). The facility includes the beam-delivery systems for the Los Alamos Neutron Scattering Center and the Weapons Neutron Research Facility (LANSCE/WNR). The program is designed not only to assure the health and safety of all personnel, including users, in their work at LAMPF, and of MP-Division staff in their work on the LANSCE/WNR beam lines, but also to protect the facility (buildings and equipment) and the environment. 33 refs., 18 figs., 2 tabs

  3. Running ATLAS workloads within massively parallel distributed applications using Athena Multi-Process framework (AthenaMP)

    CERN Document Server

    Calafiura, Paolo; The ATLAS collaboration; Seuster, Rolf; Tsulaia, Vakhtang; van Gemmeren, Peter

    2015-01-01

    AthenaMP is a multi-process version of the ATLAS reconstruction and data analysis framework Athena. By leveraging Linux fork and copy-on-write, it allows the sharing of memory pages between event processors running on the same compute node with little to no change in the application code. Originally targeted to optimize the memory footprint of reconstruction jobs, AthenaMP has demonstrated that it can reduce the memory usage of certain confugurations of ATLAS production jobs by a factor of 2. AthenaMP has also evolved to become the parallel event-processing core of the recently developed ATLAS infrastructure for fine-grained event processing (Event Service) which allows to run AthenaMP inside massively parallel distributed applications on hundreds of compute nodes simultaneously. We present the architecture of AthenaMP, various strategies implemented by AthenaMP for scheduling workload to worker processes (for example: Shared Event Queue and Shared Distributor of Event Tokens) and the usage of AthenaMP in the...

  4. Running ATLAS workloads within massively parallel distributed applications using Athena Multi-Process framework (AthenaMP)

    CERN Document Server

    Calafiura, Paolo; Seuster, Rolf; Tsulaia, Vakhtang; van Gemmeren, Peter

    2015-01-01

    AthenaMP is a multi-process version of the ATLAS reconstruction, simulation and data analysis framework Athena. By leveraging Linux fork and copy-on-write, it allows for sharing of memory pages between event processors running on the same compute node with little to no change in the application code. Originally targeted to optimize the memory footprint of reconstruction jobs, AthenaMP has demonstrated that it can reduce the memory usage of certain configurations of ATLAS production jobs by a factor of 2. AthenaMP has also evolved to become the parallel event-processing core of the recently developed ATLAS infrastructure for fine-grained event processing (Event Service) which allows to run AthenaMP inside massively parallel distributed applications on hundreds of compute nodes simultaneously. We present the architecture of AthenaMP, various strategies implemented by AthenaMP for scheduling workload to worker processes (for example: Shared Event Queue and Shared Distributor of Event Tokens) and the usage of Ath...

  5. The European ruminants during the "Microbunodon Event" (MP28, Latest Oligocene): impact of climate changes and faunal event on the ruminant evolution.

    Science.gov (United States)

    Mennecart, Bastien

    2015-01-01

    The Earth already experienced numerous episodes of global warming and cooling. One of the latest impressive events of temperature rising was the Late Oligocene Warming that occurred around 25 Mya. An increase of the marine temperature of 2 to 4°C has been observed in a short time interval. In Europe, this major climatic event can be correlated to the continental faunal turnover "Microbunodon Event". This event is marked by a huge faunal turnover (40% of the ungulate fauna during the first 500k years) and environmental changes. Drier conditions associated to the appearance of the seasonality lead to new environmental conditions dominated by wooded savannahs. This is correlated to a major arrival of Asiatic immigrants. Moreover, from a homogenous fauna during the main part of the Oligocene, local climatic variations between the European Western coast and the more central Europe could have provided faunal regionalism during the latest Oligocene and earliest Miocene. Considering the ruminants, this event is the major ever known for this group in Europe. A total renewal at the family level occurred. Thanks to a precise stratigraphic succession, major evolutionary elements are highlighted. Typical Oligocene species, mainly Tragulina, were adapted to wooded environments and were leaves/fruits eaters. They disappeared at the end of MP27 or the early MP28. This corresponds to the appearance of the Asiatic immigrants. The Tragulina (Lophiomerycidae, Bachitheriidae) and stem Pecora gave way to more derived stem and maybe crown Pecora (e.g. "Amphitragulus", Babameryx, Dremotherium). These newcomers were adapted to more open environments and mixed feeding. The disappearance of the Tragulina is probably linked to environmental and vegetation changes, and competition. They give way to more derived ruminants having a more efficient metabolism in drier conditions and a better assimilation of less energetic food.

  6. Comparison of the Adverse Event Profile of TheraSphere® with SIR-Spheres® for the Treatment of Unresectable Hepatocellular Carcinoma: A Systematic Review.

    Science.gov (United States)

    Kallini, Joseph Ralph; Gabr, Ahmed; Thorlund, Kristian; Balijepalli, Chakrapani; Ayres, Dieter; Kanters, Steve; Ebrahim, Shanil; Mills, Edward; Lewandowski, Robert J; Salem, Riad

    2017-07-01

    To compare the safety profiles of TheraSphere ® (glass) and SIR-Spheres ® (resin) Y90 microspheres for the treatment of hepatocellular carcinoma. A systematic review was conducted using the databases MEDLINE, Embase, and Cochrane Trials Register to identify all relevant studies. Baseline characteristics and adverse events of all grades related to gastrointestinal, hepatobiliary, and respiratory systems were collected along with commonly reported outcomes related to post-embolization syndrome. For all outcomes, data from each study were tabulated for each intervention. Adverse events and patients were summed across studies on TheraSphere ® and SIR-Spheres ® , respectively, and the resulting proportion of patients experiencing an outcome for both interventions was calculated. Thirty-one observational studies were included in the review. In the adverse events of all grades, more patients treated with resin microspheres reported gastric ulcers, hepatic encephalopathy, cholecystitis, hepatic failure, and pleural effusion. Patients treated with resin microspheres also had more hepatobiliary adverse events of grade 3 or higher. In the events related to post-embolization syndrome, glass microspheres exhibited a similar safety profile compared to resin microspheres. Ascites and nausea grade 3 or higher were recorded more frequently with glass microsphere treatment. Based on this review of the published literature, glass microspheres exhibit a safety profile with fewer gastrointestinal and pulmonary adverse events compared to resin microspheres in the treatment of hepatocellular carcinoma.

  7. MP-Division health and safety reference handbook. [Contains glossary

    Energy Technology Data Exchange (ETDEWEB)

    Putnam, T.M.

    1987-09-01

    This report presents the objectives, organization, policies, and essential rules and procedures that have been adopted by MP Division and that form the basis of the Health and Safety Program of the Clinton P. Anderson Meson Physics Facility (LAMPF). The facility includes the beam-delivery systems for the Los Alamos Neutron Scattering Center and the Weapons Neutron Research Facility (LANSCE/WNR). The program is designed not only to assure the health and safety of all personnel, including users, in their work at LAMPF, and of MP-Division staff in their work on the LANSCE/WNR beam lines, but also to protect the facility (buildings and equipment) and the environment. 33 refs., 18 figs., 2 tabs.

  8. The mitochondrial SIR2 related protein 2 (SIR2RP2 impacts Leishmania donovani growth and infectivity.

    Directory of Open Access Journals (Sweden)

    Nimisha Mittal

    2017-05-01

    Full Text Available Leishmania donovani, a protozoan parasite is the major causative agent of visceral leishmaniasis. Increased toxicity and resistance to the existing repertoire of drugs has been reported. Hence, an urgent need exists for identifying newer drugs and drug targets. Previous reports have shown sirtuins (Silent Information Regulator from kinetoplastids as promising drug targets. Leishmania species code for three SIR2 (Silent Information Regulator related proteins. Here, we for the first time report the functional characterization of SIR2 related protein 2 (SIR2RP2 of L. donovani.Recombinant L. donovani SIR2RP2 was expressed in E. coli and purified. The enzymatic functions of SIR2RP2 were determined. The subcellular localization of LdSIR2RP2 was done by constructing C-terminal GFP-tagged full-length LdSIR2RP2. Deletion mutants of LdSIR2RP2 were generated in Leishmania by double targeted gene replacement methodology. These null mutants were tested for their proliferation, virulence, cell cycle defects, mitochondrial functioning and sensitivity to known SIR2 inhibitors.Our data suggests that LdSIR2RP2 possesses NAD+-dependent ADP-ribosyltransferase activity. However, NAD+-dependent deacetylase and desuccinylase activities were not detected. The protein localises to the mitochondrion of the promastigotes. Gene deletion studies showed that ΔLdSIR2RP2 null mutants had restrictive growth phenotype associated with accumulation of cells in the G2/M phase and compromised mitochondrial functioning. The null mutants had attenuated infectivity. Deletion of LdSIR2RP2 resulted in increased sensitivity of the parasites to the known SIR2 inhibitors. The sirtuin inhibitors inhibited the ADP-ribosyltransferase activity of recombinant LdSIR2RP2. In conclusion, sirtuins could be used as potential new drug targets for visceral leishmaniasis.

  9. Tectonic geomorphology of the Andes with SIR-A and SIR-B

    Science.gov (United States)

    Bloom, Arthur L.; Fielding, Eric J.

    1986-01-01

    Data takes from SIR-A and SIR-B (Shuttle Imaging Radar) crossed all of the principal geomorphic provinces of the central Andes between 17 and 34 S latitude. In conjunction with Thematic Mapping images and photographs from hand-held cameras as well as from the Large Format Camera that was flown with SIR-B, the radar images give an excellent sampling of Andean geomorphology. In particular, the radar images show new details of volcanic rocks and landforms of late Cenozoic age in the Puna, and the exhumed surfaces of tilted blocks of Precambrian crystalline basement in the Sierras Pampeanas.

  10. Inhibition of autophagy by TAB2 and TAB3.

    Science.gov (United States)

    Criollo, Alfredo; Niso-Santano, Mireia; Malik, Shoaib Ahmad; Michaud, Mickael; Morselli, Eugenia; Mariño, Guillermo; Lachkar, Sylvie; Arkhipenko, Alexander V; Harper, Francis; Pierron, Gérard; Rain, Jean-Christophe; Ninomiya-Tsuji, Jun; Fuentes, José M; Lavandero, Sergio; Galluzzi, Lorenzo; Maiuri, Maria Chiara; Kroemer, Guido

    2011-11-11

    Autophagic responses are coupled to the activation of the inhibitor of NF-κB kinase (IKK). Here, we report that the essential autophagy mediator Beclin 1 and TGFβ-activated kinase 1 (TAK1)-binding proteins 2 and 3 (TAB2 and TAB3), two upstream activators of the TAK1-IKK signalling axis, constitutively interact with each other via their coiled-coil domains (CCDs). Upon autophagy induction, TAB2 and TAB3 dissociate from Beclin 1 and bind TAK1. Moreover, overexpression of TAB2 and TAB3 suppresses, while their depletion triggers, autophagy. The expression of the C-terminal domain of TAB2 or TAB3 or that of the CCD of Beclin 1 competitively disrupts the interaction between endogenous Beclin 1, TAB2 and TAB3, hence stimulating autophagy through a pathway that requires endogenous Beclin 1, TAK1 and IKK to be optimally efficient. These results point to the existence of an autophagy-stimulatory 'switch' whereby TAB2 and TAB3 abandon inhibitory interactions with Beclin 1 to engage in a stimulatory liaison with TAK1.

  11. Post-event spontaneous intrusive recollections and strength of memory for emotional events in men and women

    Science.gov (United States)

    Ferree, Nikole K.; Cahill, Larry

    2009-01-01

    Spontaneous intrusive recollections (SIRs) follow traumatic events in clinical and non-clinical populations. To determine whether any relationship exists between SIRs and enhanced memory for emotional events, participants viewed emotional or neutral films, had their memory for the films tested two days later, and estimated the number of SIRs they experienced for each film. SIR frequency related positively to memory strength, an effect more pronounced in the emotional condition. These findings represent the first demonstration of a relationship between SIRs occurring after an emotional experience and subsequent memory strength for that experience. The results are consistent with the possibility that emotional arousal leads both to elevated SIR frequency and better memory, and that the covert rehearsal associated with SIRs enhances memory for emotional relative to neutral stimuli. Additional evidence of menstrual cycle influences on SIR incidence in female participants appears to merit consideration in future work. PMID:19131257

  12. Science and controversy a biography of Sir Norman Lockyer

    CERN Document Server

    Meadows, A

    2008-01-01

    Sir Norman Lockyer left Nature, the world''s leading scientific journal, as his lasting memorial. But his life, and controversial theories, are an important part of science history. His ideas were at the forefront of public debate, and ranged from brilliant to perverse. This entertaining book is a fascinating insight into his eventful life

  13. "Cet obscur objet du Désir"

    Directory of Open Access Journals (Sweden)

    Reto Melchior

    1996-09-01

    Full Text Available Luis Bunuel’s last film is based on Pierre Louÿs’ La Femme et le Pantin. This now forgotten bestseller, published in 1898, is drawn from Goya s painting El Pelele, in which four women are playing with a male puppet. In Pierre Louÿs’ novel this scene is inverted so that one woman with two faces plays with four men. In Cet Obscur Objet du Désir this “femme fatale” is interpreted by two actresses. The concentric structure of the film puts focus on a scene of being excluded from knowing. The technique of continually interrupting the flash-back sequences frustrates the audience because of its exclusion from the “real” course of events and gives rise to doubts whether the male protagonist tells the truth about his love-affair or whether he satisfies the curiosity of the audience by telling them Pierre Louÿs’ novel as his own story. This ambiguous art of narration mirrors Bunuel’s claim that the main topic of Cet Obscur Objet du Désir is frustration.

  14. jmzTab: a java interface to the mzTab data standard.

    Science.gov (United States)

    Xu, Qing-Wei; Griss, Johannes; Wang, Rui; Jones, Andrew R; Hermjakob, Henning; Vizcaíno, Juan Antonio

    2014-06-01

    mzTab is the most recent standard format developed by the Proteomics Standards Initiative. mzTab is a flexible tab-delimited file that can capture identification and quantification results coming from MS-based proteomics and metabolomics approaches. We here present an open-source Java application programming interface for mzTab called jmzTab. The software allows the efficient processing of mzTab files, providing read and write capabilities, and is designed to be embedded in other software packages. The second key feature of the jmzTab model is that it provides a flexible framework to maintain the logical integrity between the metadata and the table-based sections in the mzTab files. In this article, as two example implementations, we also describe two stand-alone tools that can be used to validate mzTab files and to convert PRIDE XML files to mzTab. The library is freely available at http://mztab.googlecode.com. © 2014 The Authors PROTEOMICS Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast.

    Science.gov (United States)

    Hannan, Abdul; Abraham, Neethu Maria; Goyal, Siddharth; Jamir, Imlitoshi; Priyakumar, U Deva; Mishra, Krishnaveni

    2015-12-02

    Silent information regulator 2 (Sir2), the founding member of the conserved sirtuin family of NAD(+)-dependent histone deacetylase, regulates several physiological processes including genome stability, gene silencing, metabolism and life span in yeast. Within the nucleus, Sir2 is associated with telomere clusters in the nuclear periphery and rDNA in the nucleolus and regulates gene silencing at these genomic sites. How distribution of Sir2 between telomere and rDNA is regulated is not known. Here we show that Sir2 is sumoylated and this modification modulates the intra-nuclear distribution of Sir2. We identify Siz2 as the key SUMO ligase and show that multiple lysines in Sir2 are subject to this sumoylation activity. Mutating K215 alone counteracts the inhibitory effect of Siz2 on telomeric silencing. SUMO modification of Sir2 impairs interaction with Sir4 but not Net1 and, furthermore, SUMO modified Sir2 shows predominant nucleolar localization. Our findings demonstrate that sumoylation of Sir2 modulates distribution between telomeres and rDNA and this is likely to have implications for Sir2 function in other loci as well. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  16. Agro-transformation and evaluation of resistance to Phytophthora infestansin Solanum tuberosumL. variety Désirée

    Directory of Open Access Journals (Sweden)

    Jeanette Orbegozo

    2014-03-01

    Full Text Available The Oomycete Phytophthora infestans (Mont. de Bary, the causal agent of the disease known as late blight, is primarily responsible for the decreased in production performance and potato crops worldwide. The integration of the complete Rgenes sequences in the potato genome using Agro-transformation appears an alternative to be considered in the fight against this pathogen. The Rpi-blb2 gene (Rgene from the wild species Solanum bulbocastanumDunal shows a broad resistance to isolates ofP. infestans,making it an important candidate for plant breeding studies. This paper reports the integration of the Rpi-blb2gene into potato var. Désirée genome by Agrobacterium tumefaciens- mediated transformation system, the molecular characterization of 29 events transformed and whole plant infection with isolate POX67 of P. infestansfrom Peru. Désirée events [Rpi-blb2] 4 and Désirée [Rpi-blb2] 30, showed a substantial resistance to P. infestansinfection confirming complete transfer of the Rpi-blb2gene from a wild species to a cultivated species by genetic transformation.

  17. Registration of Mp718 and Mp719 germplasm lines of maize

    Science.gov (United States)

    Maize (Zea mays L.) germplasm lines Mp718 (Reg. No. GP-xxxx, PI 662045) and Mp719 (Reg. No. GP-xxxx, PI 662046) were developed and released by USDA-ARS in cooperation with the Mississippi Agricultural and Forestry Experiment Station, Mississippi State, Mississippi, as sources of resistance to aflat...

  18. SirR, a Novel Iron-Dependent Repressor in Staphylococcus epidermidis

    Science.gov (United States)

    Hill, Philip J.; Cockayne, Alan; Landers, Patrick; Morrissey, Julie A.; Sims, Catriona M.; Williams, Paul

    1998-01-01

    In Staphylococcus epidermidis and Staphylococcus aureus, a number of cell wall- and cytoplasmic membrane-associated lipoproteins are induced in response to iron starvation. To gain insights into the molecular basis of iron-dependent gene regulation in the staphylococci, we sequenced the DNA upstream of the 3-kb S. epidermidis sitABC operon, which Northern blot analysis indicates is transcriptionally regulated by the growth medium iron content. We identified two DNA sequences which are homologous to elements of the Corynebacterium diphtheriae DtxR regulon, which controls, in response to iron stress, for example, production of diphtheria toxin, siderophore, and a heme oxygenase. Upstream of the sitABC operon and divergently transcribed lies a 645-bp open reading frame (ORF), which codes for a polypeptide of approximately 25 kDa with homology to the DtxR family of metal-dependent repressor proteins. This ORF has been designated SirR (staphylococcal iron regulator repressor). Within the sitABC promoter/operator region, we also located a region of dyad symmetry overlapping the transcriptional start of sitABC which shows high homology to the DtxR operator consensus sequence, suggesting that this region, termed the Sir box, is the SirR-binding site. The SirR protein was overexpressed, purified, and used in DNA mobility shift assays; SirR retarded the migration of a synthetic oligonucleotide based on the Sir box in a metal (Fe2+ or Mn2+)-dependent manner, providing confirmatory evidence that this motif is the SirR-binding site. Furthermore, Southern blot analysis of staphylococcal chromosomal DNA with the synthetic Sir box as a probe confirmed that there are at least five Sir boxes in the S. epidermidis genome and at least three in the genome of S. aureus, suggesting that SirR controls the expression of multiple target genes. Using a monospecific polyclonal antibody raised against SirR to probe Western blots of whole-cell lysates of S. aureus, S. carnosus, S. epidermidis

  19. The European Ruminants during the “Microbunodon Event” (MP28, Latest Oligocene): Impact of Climate Changes and Faunal Event on the Ruminant Evolution

    Science.gov (United States)

    Mennecart, Bastien

    2015-01-01

    The Earth already experienced numerous episodes of global warming and cooling. One of the latest impressive events of temperature rising was the Late Oligocene Warming that occurred around 25 Mya. An increase of the marine temperature of 2 to 4°C has been observed in a short time interval. In Europe, this major climatic event can be correlated to the continental faunal turnover “Microbunodon Event”. This event is marked by a huge faunal turnover (40% of the ungulate fauna during the first 500k years) and environmental changes. Drier conditions associated to the appearance of the seasonality lead to new environmental conditions dominated by wooded savannahs. This is correlated to a major arrival of Asiatic immigrants. Moreover, from a homogenous fauna during the main part of the Oligocene, local climatic variations between the European Western coast and the more central Europe could have provided faunal regionalism during the latest Oligocene and earliest Miocene. Considering the ruminants, this event is the major ever known for this group in Europe. A total renewal at the family level occurred. Thanks to a precise stratigraphic succession, major evolutionary elements are highlighted. Typical Oligocene species, mainly Tragulina, were adapted to wooded environments and were leaves/fruits eaters. They disappeared at the end of MP27 or the early MP28. This corresponds to the appearance of the Asiatic immigrants. The Tragulina (Lophiomerycidae, Bachitheriidae) and stem Pecora gave way to more derived stem and maybe crown Pecora (e.g. “Amphitragulus”, Babameryx, Dremotherium). These newcomers were adapted to more open environments and mixed feeding. The disappearance of the Tragulina is probably linked to environmental and vegetation changes, and competition. They give way to more derived ruminants having a more efficient metabolism in drier conditions and a better assimilation of less energetic food. PMID:25692298

  20. An introduction to the Micrel Micropump MP Daily portable syringe driver.

    Science.gov (United States)

    Groves, Karen E

    2003-11-01

    In this article the author describes the Micrel Micropump MP Daily (MP Daily) portable syringe driver. This follows the author's experience of a 4-month pilot of the device by an inpatient palliative care unit. Portable syringe drivers are commonly used to deliver continuous subcutaneous infusions in palliative care situations. Those in current use are not without problems and serious adverse events have occasionally been reported, mainly resulting from confusion between models. The MP Daily syringe driver addresses some of these issues while remaining small, lightweight and inexpensive, with a long battery life and fitting into the pocket of a shirt of pyjama jacket. Improvements over current models include an on/off button, the absence of facilities to set a zero rate or change the rate once the syringe driver is running, and the absence of a boost button. In addition, there are improved alarms, a message display system and a configuration menu. Although confusion remains a problem, and the ideal has not yet been reached, the MP Daily goes some considerable way towards reducing risks and opportunities for human error.

  1. Analytical gradients for tensor hyper-contracted MP2 and SOS-MP2 on graphical processing units

    Science.gov (United States)

    Song, Chenchen; Martínez, Todd J.

    2017-10-01

    Analytic energy gradients for tensor hyper-contraction (THC) are derived and implemented for second-order Møller-Plesset perturbation theory (MP2), with and without the scaled-opposite-spin (SOS)-MP2 approximation. By exploiting the THC factorization, the formal scaling of MP2 and SOS-MP2 gradient calculations with respect to system size is reduced to quartic and cubic, respectively. An efficient implementation has been developed that utilizes both graphics processing units and sparse tensor techniques exploiting spatial sparsity of the atomic orbitals. THC-MP2 has been applied to both geometry optimization and ab initio molecular dynamics (AIMD) simulations. The resulting energy conservation in micro-canonical AIMD demonstrates that the implementation provides accurate nuclear gradients with respect to the THC-MP2 potential energy surfaces.

  2. A Novel Method of SIR Measurement for Power Control in CDMA Systems

    International Nuclear Information System (INIS)

    Yu, J; Wu, S B; He, J Z

    2006-01-01

    CDMA is interference limited multiple access system. Power control is an effective way to reduce co-channel interference and solve the near-far problem. Consequently, it can improve the system capacity, and make higher data rate possible. CDMA2000 employs fast closed-loop power control in reverse link to combat channel fading, and the estimation of signal to interference ratio (SIR) is required for closed-loop power control. Transmitting power is adjusted by comparing the SIR estimation with SIR target. So, it is crucial to measure the SIR of received signal accurately. Traditional measurement methods mostly depend on pilot signal strongly, when the pilots are few, there is a greater error brought to the measurement of SIR. In this paper, we discuss the SIR measurement of the received signal under the fewer pilots condition (especially only one pilot symbol) and present a novel SIR measurement method. According to the simulation, the numerical results indicate that the SIR measured by the proposed method is more accurate than the SIR measured by conventional method under fewer pilots condition

  3. MELCOR 1.8.2 assessment: The MP-1 and MP-2 late phase melt progression experiments

    International Nuclear Information System (INIS)

    Tautges, T.J.

    1994-05-01

    MELCOR is a fully integrated, engineering-level computer code being developed at Sandia National Laboratories for the USNRC, that models the entire spectrum of severe accident phenomena in a unified framework for both BWRs and PWRs. As a part of an ongoing assessment program, MELCOR has been used to model the MP-1 and MP-2 experiments, which provided data for late-phase melt progression in PWR geometries. Core temperature predicted by MELCOR were within 250--500 K of measured data in both MP-1 and MP-2. Relocation in the debris bed and metallic crust regions of MP-2 was predicted accurately compared to PIE data. Temperature gradients in lower portions of the test bundle were not predicted well in both MP-1 and MP-2, due to the lack of modeling of the heat transfer path to the cooling jacket in those portions of the test bundles. Fifteen sensitivity studies were run on various core (COR), control volume hydrodynamics (CVH) and heat structures (HS) package parameters. No unexpected sensitivities were found, and in particular there were no sensitivities to reduced time step, finer nodalization or to computer platform. Calculations performed by the DEBRIS and TAC2D codes for MP-1 and MP-2 showed better agreement with measured data than those performed by MELCOR. This was expected, through, due to the fully 2-dimensional modeling used in the other codes

  4. First measurement of 153Sm in the SIR

    International Nuclear Information System (INIS)

    Michotte, C.; Ratel, G.; Lucas, L.

    1999-01-01

    In June 1998, the NIST sent to the International Reference System (SIR) a solution of 153 Sm standardized in a 4π ionization chamber. As this radionuclide had not previously been measured in the SIR, the resulting equivalent activity A e,NIST is compared with the value calculated from the efficiency curve of the SIR. However, problems occurred owing to the presence of 154 Eu and 156 Eu impurities in the solution. The manner in which the final equivalent activity value for this solution of 153 Sm has been deduced is described in this report. (authors)

  5. Lymphocyte integrin expression differences between SIRS and sepsis patients.

    Science.gov (United States)

    Heffernan, D S; Monaghan, S F; Ayala, Alfred

    2017-11-01

    Systemic Inflammatory Response Syndrome (SIRS) and sepsis remain leading causes of death. Despite many similarities, the two entities are very distinct clinically and immunologically. T-Lymphocytes play a key pivotal role in the pathogenesis and ultimately outcome following both SIRS and sepsis. Integrins are essential in the trafficking and migration of lymphocytes. They also serve vital roles in efficient wound healing and clearance of infections. Here, we investigate whether integrin expression, specifically β1 (CD29) and β2 (CD18), are disrupted in SIRS and sepsis, and assess differences in integrin expression between these two critically ill clinical categories. T-Lymphocytes were isolated from whole blood collected from ICU patients exhibiting SIRS or sepsis. Samples were analyzed for CD18 (β2) and CD29 (β1) on CD3 + T cells through flow cytometry. Septic patients were stratified into either exclusively abdominal or non-abdominal sources of sepsis. CD18 was almost ubiquitously expressed on CD3 + T cells irrespective of clinical condition. However, CD29 (β1 integrin) was lowest in SIRS patients (20.4% of CD3 + T cells) when compared with either septic patients (35.5%) or healthy volunteers (54.1%). Furthermore, there was evidence of compartmentalization in septic patients, where abdominal sources had a greater percentage of CD3 + CD29 + T cells (41.7%) when compared with those with non-abdominal sources (29.5%). Distinct differences in T-cell integrin expression exists between patients in SIRS versus sepsis, as well as relative to the source of sepsis. Further work is needed to understand cause and effect relative to the progression from SIRS into sepsis.

  6. Validation of the Spanish SIRS with monolingual Hispanic outpatients.

    Science.gov (United States)

    Correa, Amor A; Rogers, Richard; Hoersting, Raquel

    2010-09-01

    Psychologists are faced with formidable challenges in making their assessment methods relevant to growing numbers of Hispanic clients for whom English is not the primary or preferred language. Among other clinical issues, the determination of malingering has profound consequences for clients. In this investigation, we evaluated a Spanish translation of the Structured Interview of Reported Symptoms (SIRS; Rogers, Bagby, & Dickens, 1992) with 80 Spanish-speaking Hispanic American outpatients. Using a between-subjects simulation design, the Spanish SIRS was found to produce reliable results with small standard errors of measurement. Regarding validity, very large effect sizes (mean Cohen's d= 2.00) were observed between feigners and honest responders for the SIRS primary scales. We consider the potential role of the Spanish SIRS with reference to Spanish translations for other assessment instruments.

  7. The Systemic Inflammatory Response Syndrome (SIRS in acutely hospitalised medical patients: a cohort study

    Directory of Open Access Journals (Sweden)

    Storgaard Merete

    2009-12-01

    Full Text Available Abstract Background Sepsis is an infection which has evoked a systemic inflammatory response. Clinically, the Systemic Inflammatory Response Syndrome (SIRS is identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The relationship between SIRS symptoms and morbidity and mortality in medical emergency ward patients is unknown. Methods We conducted a prospective cohort study of the frequency of SIRS and its relationship to sepsis and death among acutely hospitalised medical patients. In 437 consecutive patients, SIRS status, blood pressure, infection and comorbidity on admission was registered together with 28-day mortality. Results A hundred and fifty-four patients (35% had SIRS on admission, 211 patients (48% had no SIRS, and 72 patients (16% had insufficient data to evaluate their SIRS status. SIRS patients were 2.2 times more frequently infected, with 66/154 SIRS patients versus 41/211 non-SIRS patients: p Conclusion We found SIRS status on admission to be moderately associated with infection and strongly related to 28-day mortality.

  8. On the Role of Ionospheric Ions in Sawtooth Events

    Science.gov (United States)

    Lund, E. J.; Nowrouzi, N.; Kistler, L. M.; Cai, X.; Frey, H. U.

    2018-01-01

    Simulations have suggested that feedback of heavy ions originating in the ionosphere is an important mechanism for driving sawtooth injections. However, this feedback may only be necessary for events driven by coronal mass ejections (CMEs), whereas in events driven by streaming interaction regions (SIRs), solar wind variability may suffice to drive these injections. Here we present case studies of two sawtooth events for which in situ data are available in both the magnetotail (Cluster) and the nightside auroral region (FAST), as well as global auroral images (IMAGE). One event, on 1 October 2001, was driven by a CME; the other, on 24 October 2002, was driven by an SIR. The available data do not support the hypothesis that heavy ion feedback is necessary to drive either event. This result is consistent with simulations of the SIR-driven event but disagrees with simulation results for a different CME-driven event. We also find that in an overwhelming majority of the sawtooth injections for which Cluster tail data are available, the O+ observed in the tail comes from the cusp rather than the nightside auroral region, which further casts doubt on the hypothesis that ionospheric heavy ion feedback is the cause of sawtooth injections.

  9. Sir Ronald A. Fisher and the International Biometric Society.

    Science.gov (United States)

    Billard, Lynne

    2014-06-01

    The year 2012 marks the 50th anniversary of the death of Sir Ronald A. Fisher, one of the two Fathers of Statistics and a Founder of the International Biometric Society (the "Society"). To celebrate the extraordinary genius of Fisher and the far-sighted vision of Fisher and Chester Bliss in organizing and promoting the formation of the Society, this article looks at the origins and growth of the Society, some of the key players and events, and especially the roles played by Fisher himself as the First President. A fresh look at Fisher, the man rather than the scientific genius is also presented. © 2014, The International Biometric Society.

  10. Comparison of 3MP medical-grade to 1MP office grade LCD monitors in mammographic diagnostic and perceptual performance

    International Nuclear Information System (INIS)

    Ong, Aaron; Tan, Shu.; Gledhill, Samuel; Hennessy, Oliver; Lui, Belinda; Lee, Alan; Lemish, Wayne; Styles, Colin; Pun, Emma; Padmanabhan, Meenakshi; Pitman, Alexander G.; Tauro, Paul; Waugh, Paul

    2011-01-01

    Full text: Picture archiving and communication systems images designed to be viewed on high-resolution medical-grade monitors are routinely viewed on office-grade monitors on the wards or at home. This study aimed to determine whether a statistically significant difference in diagnostic (cancer detection) and perceptual (microcalcification detection) performance exists between 3MP grade and 1MP office-grade monitors. 3MP Dome medical-grade liquid crystal display (LCD) monitors (Planar, Beaverton, OR, USA) were compared to 1MP Dell office-grade LCD monitors (Dell Inc, Round Rock, TX, USA). Eight radiologists (reader experi ence 8-30 years) read the same set of 100 mammograms (23/100 with proven cancers and 52/100 with microcalcifications) presented in random order on three occasions separated by two time intervals of 12 weeks. Reads 1 and 3 utilised 3MP monitors and formed the baseline read. Read 2 utilised 1MP monitors and constituted the experimental read. Reading conditions were standardised. Readers were aware of which monitors they were using. Mul tivariate logistic regression analysis (to account for reader variability and monitor impact) was performed to assess for statistical significance. At a = 5%, confidence intervals analysis comparing the measured parameters between 1MP to 3MP monitors demonstrated no statistically significant difference in diagnostic and perceptual performance for the reader group. In cancer detection (the diagnostic task), reader accuracy remained high irrespective of monitor type. Regression analysis comparing performance with 1MP against 3MP monitors found P values of 0.693 and 0.324 for diagnostic and perceptual performance, respectively. There were no statistically and clinically significant differences between 3MP and 1MP monitors in mammographic diagnostic and perceptual performance. Comparable performance may be due to compensatory behav iour by readers.

  11. Analytic energy gradients for orbital-optimized MP3 and MP2.5 with the density-fitting approximation: An efficient implementation.

    Science.gov (United States)

    Bozkaya, Uğur

    2018-03-15

    Efficient implementations of analytic gradients for the orbital-optimized MP3 and MP2.5 and their standard versions with the density-fitting approximation, which are denoted as DF-MP3, DF-MP2.5, DF-OMP3, and DF-OMP2.5, are presented. The DF-MP3, DF-MP2.5, DF-OMP3, and DF-OMP2.5 methods are applied to a set of alkanes and noncovalent interaction complexes to compare the computational cost with the conventional MP3, MP2.5, OMP3, and OMP2.5. Our results demonstrate that density-fitted perturbation theory (DF-MP) methods considered substantially reduce the computational cost compared to conventional MP methods. The efficiency of our DF-MP methods arise from the reduced input/output (I/O) time and the acceleration of gradient related terms, such as computations of particle density and generalized Fock matrices (PDMs and GFM), solution of the Z-vector equation, back-transformations of PDMs and GFM, and evaluation of analytic gradients in the atomic orbital basis. Further, application results show that errors introduced by the DF approach are negligible. Mean absolute errors for bond lengths of a molecular set, with the cc-pCVQZ basis set, is 0.0001-0.0002 Å. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  12. Duplex tab exhaust nozzle

    Science.gov (United States)

    Gutmark, Ephraim Jeff (Inventor); Martens, Steven (nmn) (Inventor)

    2012-01-01

    An exhaust nozzle includes a conical duct terminating in an annular outlet. A row of vortex generating duplex tabs are mounted in the outlet. The tabs have compound radial and circumferential aft inclination inside the outlet for generating streamwise vortices for attenuating exhaust noise while reducing performance loss.

  13. Mesenteric panniculitis (MP) in CT. A predictor of malignancy?; Mesenteriale Pannikulitis (MP) im CT-Schnittbild. Ein Praediktor fuer ein Malignom?

    Energy Technology Data Exchange (ETDEWEB)

    Scheer, F.; Wissgott, C.; Andresen, R. [Westkuestenklinikum Heide (Germany). Inst. of Diagnostic and Interventional Radiology/Neuroradiology; Spunar, P. [Radiology Center Peine (Germany); Wiggermann, P. [University Hospital Regensburg (Germany). Dept. of Radiology

    2016-10-15

    The exact etiology of mesenteric panniculitis (MP) is still unknown and has been discussed in relation to different causes. The aim of this retrospective study was to evaluate a coherence between MP and malignancy. Retrospective analysis of consecutive CT abdomen examinations of 5595 patients in terms of MP over a period of 3 years was performed. To make the diagnosis of MP, three of five typical signs were obligatory: hyperdense mass lesion with intercalated nodules, a ''fat-ring sign'' or halo sign, a hyperdense pseudocapsule and displacement of bowel loops. The patient cohort (mean age: 64.7 years) consisted of 1974 (35.2 %) patients with histologically confirmed cancer and 3621 patients (64.8 %) without known underlying oncological disease. A total of 143 cases were diagnosed with MP (2.55 %). The average age of patients was 69.9 years with a male to female ratio of 2:1. In this group oncological disease was confirmed in 107 patients (74.8 %). In 36 patients with MP (25.2 %), no malignancy was present. In the group of patients with an underlying oncological disease, the prevalence of MP was 5.42 % and was significantly higher (p < 0.005) than in the patients with MP and without an oncological disease. The highest prevalence of MP (29 cases) was observed in non-Hodgkin lymphoma (22.6 %). The statistically calculated risk of a tumor disease in this collective is about 5 times higher if MP was demonstrated (p < 0.001). Based on the data of the collective, the risk of malignancy is five times higher in the presence of MP than in an inconspicuous mesentery. MP seems to frequently occur with non-Hodgkin lymphoma. MP can be seen on the basis of typical morphological features on the CT image. MP must be differentiated from a wide range of benign and malignant diseases of the mesentery.

  14. SirT1 regulates energy metabolism and response to caloric restriction in mice.

    Directory of Open Access Journals (Sweden)

    Gino Boily

    Full Text Available The yeast sir2 gene and its orthologues in Drosophila and C. elegans have well-established roles in lifespan determination and response to caloric restriction. We have studied mice carrying two null alleles for SirT1, the mammalian orthologue of sir2, and found that these animals inefficiently utilize ingested food. These mice are hypermetabolic, contain inefficient liver mitochondria, and have elevated rates of lipid oxidation. When challenged with a 40% reduction in caloric intake, normal mice maintained their metabolic rate and increased their physical activity while the metabolic rate of SirT1-null mice dropped and their activity did not increase. Moreover, CR did not extend lifespan of SirT1-null mice. Thus, SirT1 is an important regulator of energy metabolism and, like its orthologues from simpler eukaryotes, the SirT1 protein appears to be required for a normal response to caloric restriction.

  15. Degradation pathways of 1-methylphenanthrene in bacterial Sphingobium sp. MP9-4 isolated from petroleum-contaminated soil.

    Science.gov (United States)

    Zhong, Jianan; Luo, Lijuan; Chen, Baowei; Sha, Sha; Qing, Qing; Tam, Nora F Y; Zhang, Yong; Luan, Tiangang

    2017-01-30

    Alkylated polycyclic aromatic hydrocarbons (PAHs) are abundant in petroleum, and alkylated phenanthrenes are considered as the primary PAHs during some oil spill events. Bacterial strain of Sphingobium sp. MP9-4, isolated from petroleum-contaminated soil, was efficient to degrade 1-methylphenanthrene (1-MP). A detailed metabolism map of 1-MP in this strain was delineated based on analysis of metabolites with gas chromatograph-mass spectrometer (GC-MS). 1-MP was initially oxidized via two different biochemical strategies, including benzene ring and methyl-group attacks. Benzene ring attack was initiated with dioxygenation of the non-methylated aromatic ring via similar degradation pathways of phenanthrene (PHE) by bacteria. For methyl-group attack, mono oxygenase system was involved and more diverse enzymes were needed than that of PHE degradation. This study enhances the understanding of the metabolic pathways of alkylated PAHs and shows the significant potential of Sphingobium sp. MP9-4 for the bioremediation of alkylated PAHs contaminated environments. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. 33 CFR 147.817 - Sir Douglas Morpeth Tension Leg Platform safety zone.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Sir Douglas Morpeth Tension Leg... HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES SAFETY ZONES § 147.817 Sir Douglas Morpeth Tension Leg Platform safety zone. (a) Description. The Sir Douglas Morpeth Tension Leg Platform (Morpeth...

  17. New Processing of Spaceborne Imaging Radar-C (SIR-C) Data

    Science.gov (United States)

    Meyer, F. J.; Gracheva, V.; Arko, S. A.; Labelle-Hamer, A. L.

    2017-12-01

    The Spaceborne Imaging Radar-C (SIR-C) was a radar system, which successfully operated on two separate shuttle missions in April and October 1994. During these two missions, a total of 143 hours of radar data were recorded. SIR-C was the first multifrequency and polarimetric spaceborne radar system, operating in dual frequency (L- and C- band) and with quad-polarization. SIR-C had a variety of different operating modes, which are innovative even from today's point of view. Depending on the mode, it was possible to acquire data with different polarizations and carrier frequency combinations. Additionally, different swaths and bandwidths could be used during the data collection and it was possible to receive data with two antennas in the along-track direction.The United States Geological Survey (USGS) distributes the synthetic aperture radar (SAR) images as single-look complex (SLC) and multi-look complex (MLC) products. Unfortunately, since June 2005 the SIR-C processor has been inoperable and not repairable. All acquired SLC and MLC images were processed with a course resolution of 100 m with the goal of generating a quick look. These images are however not well suited for scientific analysis. Only a small percentage of the acquired data has been processed as full resolution SAR images and the unprocessed high resolution data cannot be processed any more at the moment.At the Alaska Satellite Facility (ASF) a new processor was developed to process binary SIR-C data to full resolution SAR images. ASF is planning to process the entire recoverable SIR-C archive to full resolution SLCs, MLCs and high resolution geocoded image products. ASF will make these products available to the science community through their existing data archiving and distribution system.The final paper will describe the new processor and analyze the challenges of reprocessing the SIR-C data.

  18. How Good is OpenMP

    Directory of Open Access Journals (Sweden)

    Timothy G. Mattson

    2003-01-01

    Full Text Available The OpenMP standard defines an Application Programming Interface (API for shared memory computers. Since its introduction in 1997, it has grown to become one of the most commonly used API's for parallel programming. But success in the market doesn't necessarily imply successful computer science. Is OpenMP a "good" programming environment? What does it even mean to call a programming environment good? And finally, once we understand how good or bad OpenMP is; what can we do to make it even better? In this paper, we will address these questions.

  19. A study of $CP$ violation in $B^\\mp \\rightarrow Dh^\\mp$ ($h=K,\\pi$) with the modes $D \\rightarrow K^\\mp \\pi^\\pm \\pi^0$, $D \\rightarrow \\pi^+\\pi^-\\pi^0$ and $D \\rightarrow K^+K^-\\pi^0$

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Anderson, Jonathan; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; d'Argent, Philippe; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Bel, Lennaert; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bertolin, Alessandro; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Birnkraut, Alex; Bizzeti, Andrea; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Braun, Svende; Brett, David; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Brook, Nicholas; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Campana, Pierluigi; Campora Perez, Daniel; Capriotti, Lorenzo; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carniti, Paolo; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casanova Mohr, Raimon; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cavallero, Giovanni; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cogoni, Violetta; Cojocariu, Lucian; Collazuol, Gianmaria; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Crocombe, Andrew; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pieter; Davis, Adam; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Dey, Biplab; Di Canto, Angelo; Di Ruscio, Francesco; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dreimanis, Karlis; Dufour, Laurent; Dujany, Giulio; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farley, Nathanael; Farry, Stephen; Fay, Robert; Ferguson, Dianne; Fernandez Albor, Victor; Ferrari, Fabio; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fol, Philip; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; García Pardiñas, Julián; Garofoli, Justin; Garra Tico, Jordi; Garrido, Lluis; Gascon, David; Gaspar, Clara; Gastaldi, Ugo; Gauld, Rhorry; Gavardi, Laura; Gazzoni, Giulio; Geraci, Angelo; Gerick, David; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianelle, Alessio; Gianì, Sebastiana; Gibson, Valerie; Giubega, Lavinia-Helena; Gligorov, V.V.; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graverini, Elena; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Humair, Thibaud; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jawahery, Abolhassan; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Karodia, Sarah; Kelsey, Matthew; Kenyon, Ian; Kenzie, Matthew; Ketel, Tjeerd; Khanji, Basem; Khurewathanakul, Chitsanu; Klaver, Suzanne; Klimaszewski, Konrad; Kochebina, Olga; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Lohn, Stefan; Longstaff, Iain; Lopes, Jose; Lowdon, Peter; Lucchesi, Donatella; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Machefert, Frederic; Maciuc, Florin; Maev, Oleg; Maguire, Kevin; Malde, Sneha; Malinin, Alexander; Manca, Giulia; Mancinelli, Giampiero; Manning, Peter Michael; Mapelli, Alessandro; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Märki, Raphael; Marks, Jörg; Martellotti, Giuseppe; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massafferri, André; Matev, Rosen; Mathad, Abhijit; Mathe, Zoltan; Matteuzzi, Clara; Mauri, Andrea; Maurin, Brice; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; Meadows, Brian; Meier, Frank; Meissner, Marco; Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Mitzel, Dominik Stefan; Molina Rodriguez, Josue; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Müller, Janine; Müller, Katharina; Müller, Vanessa; Mussini, Manuel; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Ninci, Daniele; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Osorio Rodrigues, Bruno; Otalora Goicochea, Juan Martin; Otto, Adam; Owen, Patrick; Oyanguren, Maria Aranzazu; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parkes, Christopher; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Perret, Pascal; Pescatore, Luca; Petridis, Konstantinos; Petrolini, Alessandro; Petruzzo, Marco; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Pistone, Alessandro; Playfer, Stephen; Plo Casasus, Maximo; Poikela, Tuomas; Polci, Francesco; Poluektov, Anton; Polyakov, Ivan; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Price, Eugenia; Price, Joseph David; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Quagliani, Renato; Rachwal, Bartolomiej; Rademacker, Jonas; Rakotomiaramanana, Barinjaka; Rama, Matteo; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Redi, Federico; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vincente; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Lopez, Jairo Alexis; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rouvinet, Julien; Ruf, Thomas; Ruiz, Hugo; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santimaria, Marco; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmelzer, Timon; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Sepp, Indrek; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Silva Coutinho, Rafael; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skillicorn, Ian; Skwarnicki, Tomasz; Smith, Edmund; Smith, Eluned; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Steinkamp, Olaf; Stenyakin, Oleg; Sterpka, Christopher Francis; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Stroili, Roberto; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szczypka, Paul; Szumlak, Tomasz; T'Jampens, Stephane; Tekampe, Tobias; Teklishyn, Maksym; Tellarini, Giulia; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Todd, Jacob; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Trabelsi, Karim; Tran, Minh Tâm; Tresch, Marco; Trisovic, Ana; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Weiden, Andreas; Whitehead, Mark; Wiedner, Dirk; Wilkinson, Guy; Wilkinson, Michael; Williams, Mark Richard James; Williams, Matthew; Williams, Mike; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wyllie, Kenneth; Xie, Yuehong; Xu, Zhirui; Yang, Zhenwei; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang

    2015-06-26

    An analysis of the decays of $B^\\mp \\rightarrow D K^\\mp$ and $B^\\mp \\rightarrow D \\pi^\\mp $ is presented in which the $D$ meson is reconstructed in the three-body final states $K^\\mp \\pi^\\pm \\pi^0$, $\\pi^+ \\pi^- \\pi^0$ and $K^+ K^- \\pi^0$. Using data from LHCb corresponding to an integrated luminosity of 3.0~fb$^{-1}$ of $pp$ collisions, measurements of several $CP$ observables are performed. First observations are obtained of the suppressed ADS decay $B^\\mp \\rightarrow [\\pi^\\mp K^\\pm \\pi^0]_D \\pi^\\mp$ and the quasi-GLW decay $B^\\mp \\rightarrow [K^+ K^- \\pi^0]_D \\pi^\\mp$. The results are interpreted in the context of the unitarity triangle angle $\\gamma$ and related parameters.

  20. Observation of photon polarization in $B^\\pm \\to K^\\pm\\pi^\\mp\\pi^\\pm\\gamma$ decays

    CERN Multimedia

    Veneziano, G

    2014-01-01

    A study of the flavor-changing neutral current radiative $B^{\\pm} \\to K^{\\pm}\\pi^{\\mp}\\pi^{\\pm}\\gamma$ decays performed using data collected in proton-proton collisions with the LHCb detector at $7$ and $8\\,$TeV center-of-mass energies is presented. In this sample, corresponding to an integrated luminosity of $3\\,\\text{fb}^{-1}$, nearly $14\\,000$ signal events are reconstructed and selected, containing all possible intermediate resonances with a $K^{\\pm}\\pi^{\\mp}\\pi^{\\pm}$ final state in the $[1.1, 1.9]$\\,GeV/$c^{2}$ mass range. The distribution of the angle of the photon direction with respect to the plane defined by the final-state hadrons in their rest frame is studied in intervals of $K^{\\pm}\\pi^{\\mp}\\pi^{\\pm}$ mass and the asymmetry between the number of signal events found on each side of the plane is obtained. The first direct observation of the photon polarization in the $b \\to s\\gamma$ transition is reported with a significance of $5.2\\,\\sigma$.

  1. Assessment of mercaptopurine (6MP) metabolites and 6MP metabolic key-enzymes in childhood acute lymphoblastic leukemia.

    Science.gov (United States)

    Wojtuszkiewicz, Anna; Barcelos, Ana; Dubbelman, Boas; De Abreu, Ronney; Brouwer, Connie; Bökkerink, Jos P; de Haas, Valerie; de Groot-Kruseman, Hester; Jansen, Gerrit; Kaspers, Gertjan L; Cloos, Jacqueline; Peters, G J

    2014-01-01

    Pediatric acute lymphoblastic leukemia (ALL) is treated with combination chemotherapy including mercaptopurine (6MP) as an important component. Upon its uptake, 6MP undergoes a complex metabolism involving many enzymes and active products. The prognostic value of all the factors engaged in this pathway still remains unclear. This study attempted to determine which components of 6MP metabolism in leukemic blasts and red blood cells are important for 6MP's sensitivity and toxicity. In addition, changes in the enzymatic activities and metabolite levels during the treatment were analyzed. In a cohort (N=236) of pediatric ALL patients enrolled in the Dutch ALL-9 protocol, we studied the enzymes inosine-5'-monophosphate dehydrogenase (IMPDH), thiopurine S-methyltransferase (TPMT), hypoxanthine guanine phosphoribosyl transferase (HGPRT), and purine nucleoside phosphorylase (PNP) as well as thioguanine nucleotides (TGN) and methylthioinosine nucleotides (meTINs). Activities of selected enzymes and levels of 6MP derivatives were measured at various time points during the course of therapy. The data obtained and the toxicity related parameters available for these patients were correlated with each other. We found several interesting relations, including high concentrations of two active forms of 6MP--TGN and meTIN--showing a trend toward association with better in vitro antileukemic effect of 6MP. High concentrations of TGN and elevated activity of HGPRT were found to be significantly associated with grade III/IV leucopenia. However, a lot of data of enzymatic activities and metabolite concentrations as well as clinical toxicity were missing, thereby limiting the number of assessed relations. Therefore, although a complex study of 6MP metabolism in ALL patients is feasible, it warrants more robust and strict data collection in order to be able to draw more reliable conclusions.

  2. Development of SIR-C Ground Calibration Equipment

    Science.gov (United States)

    Freeman, A.; Azeem, M.; Haub, D.; Sarabandi, K.

    1993-01-01

    SIR-C/X-SAR is currently scheduled for launch in April 1994. SIR-C is an L-Band and C-Band, multi-polarization spaceborne SAR system developed by NASA/JPL. X- SAR is an X-Band SAR system developed by DARA/ASI. One of the problems involved in calibrating the SIR-C instrument is to make sure that the horizontal (H) and vertical (V) polarized beams are aligned in the azimuth direction, i.e.. that they are pointing in the same direction. This is important if the polarimetric performance specifications for the system are to be met. To solve this problem, we have designed and built a prototype of a low-cost ground receiver capable of recording received power from two antennas, one H-polarized, the other V-polarized. The two signals are mixed to audio then recorded on the left and right stereo channels of a standard audio cassette player. The audio cassette recording can then be played back directly into a Macintosh computer, where it is digitized. Analysis of.

  3. Issues Identified During September 2016 IBM OpenMP 4.5 Hackathon

    Energy Technology Data Exchange (ETDEWEB)

    Richards, David F. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-03-15

    In September, 2016 IBM hosted an OpenMP 4.5 Hackathon at the TJ Watson Research Center. Teams from LLNL, ORNL, SNL, LANL, and LBNL attended the event. As with the 2015 hackathon, IBM produced an extremely useful and successful event with unmatched support from compiler team, applications staff, and facilities. Approximately 24 IBM staff supported 4-day hackathon and spent significant time 4-6 weeks out to prepare environment and become familiar with apps. This hackathon was also the first event to feature LLVM & XL C/C++ and Fortran compilers. This report records many of the issues encountered by the LLNL teams during the hackathon.

  4. Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity.

    Science.gov (United States)

    Gallo, Christopher M; Smith, Daniel L; Smith, Jeffrey S

    2004-02-01

    The Saccharomyces cerevisiae Sir2 protein is an NAD(+)-dependent histone deacetylase (HDAC) that functions in transcriptional silencing and longevity. The NAD(+) salvage pathway protein, Npt1, regulates Sir2-mediated processes by maintaining a sufficiently high intracellular NAD(+) concentration. However, another NAD(+) salvage pathway component, Pnc1, modulates silencing independently of the NAD(+) concentration. Nicotinamide (NAM) is a by-product of the Sir2 deacetylase reaction and is a natural Sir2 inhibitor. Pnc1 is a nicotinamidase that converts NAM to nicotinic acid. Here we show that recombinant Pnc1 stimulates Sir2 HDAC activity in vitro by preventing the accumulation of NAM produced by Sir2. In vivo, telomeric, rDNA, and HM silencing are differentially sensitive to inhibition by NAM. Furthermore, PNC1 overexpression suppresses the inhibitory effect of exogenously added NAM on silencing, life span, and Hst1-mediated transcriptional repression. Finally, we show that stress suppresses the inhibitory effect of NAM through the induction of PNC1 expression. Pnc1, therefore, positively regulates Sir2-mediated silencing and longevity by preventing the accumulation of intracellular NAM during times of stress.

  5. Caracterização de MP2,5 e MP10 em Ar Ambiente de Estacionamento Fechado de Estabelecimento Comercial em Londrina-Paraná

    Directory of Open Access Journals (Sweden)

    Jurandir Pereira Pinto

    2014-07-01

    Full Text Available Para investigar o perfil de concentração do MP em diferentes tamanhos aerodinâmicos presentes na atmosfera impactada pelo tráfego veicular leve, foram coletadas amostras de MP (MP2,5 e MP10 em um estacionamento comercial fechado onde circulam somente veículos leves em baixa velocidade. Foram realizadas quatro campanhas de amostragem em junho e dezembro de 2011 e 2012. O MP foi coletado utilizando ciclones (URG para MP2,5 e Low-Vol para MP10. Os filtros foram pesados em ultra balança analítica com precisão de 1,0 µg. As concentrações medias para MP2,5 e MP10 obtidas para a campanha de junho de 2011 foi de 41,9±10,1 µg m-3 e 56,4±12,6 µg m-3. Para a campanha de dezembro de 2011 obtiveram-se as concentrações médias 30,6±11,7 µg m-3 para o MP2,5 e para o MP10 52,8±12,7 µg m-3.  Em junho de 2012 o valor médio foi de 39,6 ± 9,1 µg m-3 para MP2,5 e 71,4 ± 10,9 µg m-3 de MP10. Em dezembro de 2012 as concentrações médias foram 21,3±7,2 µg m-3 para o MP2,5 e 49,9±10,6 µg m-3 para o MP10. As razões MP2,5 /MP10 com valores entre 0,42 e 0,75 mostram a variabilidade das emissões da frota veicular brasileira e da contribuição de emissões consideradas fugitivas.

  6. Disruption of murine mp29/Syf2/Ntc31 gene results in embryonic lethality with aberrant checkpoint response.

    Directory of Open Access Journals (Sweden)

    Chia-Hsin Chen

    Full Text Available Human p29 is a putative component of spliceosomes, but its role in pre-mRNA is elusive. By siRNA knockdown and stable overexpression, we demonstrated that human p29 is involved in DNA damage response and Fanconi anemia pathway in cultured cells. In this study, we generated p29 knockout mice (mp29(GT/GT using the mp29 gene trap embryonic stem cells to study the role of mp29 in DNA damage response in vivo. Interruption of mp29 at both alleles resulted in embryonic lethality. Embryonic abnormality occurred as early as E6.5 in mp29(GT/GT mice accompanied with decreased mRNA levels of α-tubulin and Chk1. The reduction of α-tubulin and Chk1 mRNAs is likely due to an impaired post-transcriptional event. An aberrant G2/M checkpoint was found in mp29 gene trap embryos when exposed to aphidicolin and UV light. This embryonic lethality was rescued by crossing with mp29 transgenic mice. Additionally, the knockdown of zfp29 in zebrafish resulted in embryonic death at 72 hours of development postfertilization (hpf. A lower level of acetylated α-tubulin was also observed in zfp29 morphants. Together, these results illustrate an indispensable role of mp29 in DNA checkpoint response during embryonic development.

  7. Aircraft rotor blade with passive tuned tab

    Science.gov (United States)

    Campbell, T. G. (Inventor)

    1985-01-01

    A structure for reducing vibratory airloading in a rotor blade with a leading edge and a trailing edge includes a cut out portion at the trailing edge. A substantially wedge shaped cross section, inertially deflectable tab, also with a leading edge and a trailing edge is pivotally mounted in the cut out portion. The trailing edge of the tab may move above and below the rotor blade. A torsion strap applies force against the tab when the trailing edge of the tab is above and below the rotor blade. A restraining member is slidably movable along the torsion strap to vary torsional biasing force supplied by the torsion bar to the tab. A plurality of movable weights positioned between plates vary a center of gravity of the tab. Skin of the tab is formed from unidirectional graphite and fiberglass layers. Sliders coupled with a pinned degree of freedom at rod eliminate bending of tab under edgewise blade deflection.

  8. Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states.

    Directory of Open Access Journals (Sweden)

    Stephanie Kueng

    Full Text Available Silent information regulator proteins Sir2, Sir3, and Sir4 form a heterotrimeric complex that represses transcription at subtelomeric regions and homothallic mating type (HM loci in budding yeast. We have performed a detailed biochemical and genetic analysis of the largest Sir protein, Sir4. The N-terminal half of Sir4 is dispensable for SIR-mediated repression of HM loci in vivo, except in strains that lack Yku70 or have weak silencer elements. For HM silencing in these cells, the C-terminal domain (Sir4C, residues 747-1,358 must be complemented with an N-terminal domain (Sir4N; residues 1-270, expressed either independently or as a fusion with Sir4C. Nonetheless, recombinant Sir4C can form a complex with Sir2 and Sir3 in vitro, is catalytically active, and has sedimentation properties similar to a full-length Sir4-containing SIR complex. Sir4C-containing SIR complexes bind nucleosomal arrays and protect linker DNA from nucleolytic digestion, but less effectively than wild-type SIR complexes. Consistently, full-length Sir4 is required for the complete repression of subtelomeric genes. Supporting the notion that the Sir4 N-terminus is a regulatory domain, we find it extensively phosphorylated on cyclin-dependent kinase consensus sites, some being hyperphosphorylated during mitosis. Mutation of two major phosphoacceptor sites (S63 and S84 derepresses natural subtelomeric genes when combined with a serendipitous mutation (P2A, which alone can enhance the stability of either the repressed or active state. The triple mutation confers resistance to rapamycin-induced stress and a loss of subtelomeric repression. We conclude that the Sir4 N-terminus plays two roles in SIR-mediated silencing: it contributes to epigenetic repression by stabilizing the SIR-mediated protection of linker DNA; and, as a target of phosphorylation, it can destabilize silencing in a regulated manner.

  9. SIR-ZEE: plataforma tecnológica para el desarrollo local SIR-ZEE: technology platform for local development

    Directory of Open Access Journals (Sweden)

    Marlen Treviño Villalobos

    2012-11-01

    Full Text Available El Sistema de Información Regional de la Zona Económica Especial (SIR-ZEE nació en Costa Rica aproximadamente en 1998, cuando se concibió la idea de crear un sistema informático para recopilar, gestionar y ofrecer temáticas generadas en forma digital por diferentes entidades públicas y privadas. En el 2008, con los fondos del Programa de Regionalización Interuniversitaria del Consejo Nacional de Rectores, se aprobó la iniciativa SIR-ZEE, Plataforma Tecnológica para el Desarrollo Local, que buscó fortalecer las capacidades productivas y las capacidades de gobernabilidad en la Región Huetar Norte mediante el acceso a la información oportuna y relevante para el desarrollo económico local. Este artículo tiene como objetivo mostrar no solo la relevancia de un sistema de información en la planificación del desarrollo local, sino también que, en la actualidad, el SIR-ZEE se está convirtiendo en una ventaja competitiva para la Región Huetar Norte, ya que facilita el proceso de toma decisiones. Los principales resultados obtenidos al final de la iniciativa fueron una propuesta metodológica para la elaboración de planes estratégicos de desarrollo local en la Región Huetar Norte, la sensibilización de los actores locales sobre la participación ciudadana en las diferentes fases de la planificación, un diagnóstico territorial con el valor agregado de contar con la información georreferenciada y disponible en un sitio web, y avances en la elaboración del Plan estratégico de desarrollo local.The Regional Information System of the Special Economic Zone (SIR-ZEE was born about the year 1998 as a computer system to collect, manage and offer thematic generated in digital format by different public and private entities. In 2008, with the funds of Interuniversity Regionalization Program the National Council of Rectors approved the initiative SIR- ZEE: Platform Technology for Local Development which sought to strengthen productive

  10. OpenMP 4.5 Validation and Verification Suite

    Energy Technology Data Exchange (ETDEWEB)

    2017-12-15

    OpenMP, a directive-based programming API, introduce directives for accelerator devices that programmers are starting to use more frequently in production codes. To make sure OpenMP directives work correctly across architectures, it is critical to have a mechanism that tests for an implementation's conformance to the OpenMP standard. This testing process can uncover ambiguities in the OpenMP specification, which helps compiler developers and users make a better use of the standard. We fill this gap through our validation and verification test suite that focuses on the offload directives available in OpenMP 4.5.

  11. The SIR model of Zika virus disease outbreak in Brazil at year 2015

    Science.gov (United States)

    Aik, Lim Eng; Kiang, Lam Chee; Hong, Tan Wei; Abu, Mohd Syafarudy

    2017-05-01

    This research study demonstrates a numerical model intended for comprehension the spread of the year 2015 Zika virus disease utilizing the standard SIR framework. In modeling virulent disease dynamics, it is important to explore whether the illness spread could accomplish a pandemic level or it could be eradicated. Information from the year 2015 Zika virus disease event is utilized and Brazil where the event began is considered in this research study. A three dimensional nonlinear differential equation is formulated and solved numerically utilizing the Euler's method in MS excel. It is appeared from the research study that, with health intercessions of public, the viable regenerative number can be decreased making it feasible for the event to cease to exist. It is additionally indicated numerically that the pandemic can just cease to exist when there are no new infected people in the populace.

  12. Orbital-Optimized MP3 and MP2.5 with Density-Fitting and Cholesky Decomposition Approximations.

    Science.gov (United States)

    Bozkaya, Uğur

    2016-03-08

    Efficient implementations of the orbital-optimized MP3 and MP2.5 methods with the density-fitting (DF-OMP3 and DF-OMP2.5) and Cholesky decomposition (CD-OMP3 and CD-OMP2.5) approaches are presented. The DF/CD-OMP3 and DF/CD-OMP2.5 methods are applied to a set of alkanes to compare the computational cost with the conventional orbital-optimized MP3 (OMP3) [Bozkaya J. Chem. Phys. 2011, 135, 224103] and the orbital-optimized MP2.5 (OMP2.5) [Bozkaya and Sherrill J. Chem. Phys. 2014, 141, 204105]. Our results demonstrate that the DF-OMP3 and DF-OMP2.5 methods provide considerably lower computational costs than OMP3 and OMP2.5. Further application results show that the orbital-optimized methods are very helpful for the study of open-shell noncovalent interactions, aromatic bond dissociation energies, and hydrogen transfer reactions. We conclude that the DF-OMP3 and DF-OMP2.5 methods are very promising for molecular systems with challenging electronic structures.

  13. Geim, Prof. Sir Andre Konstantin

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2015 Honorary. Geim, Prof. Sir Andre Konstantin FRS. Date of birth: 21 October 1958. Address: Royal Society Research Professor, University of Manchester, Oxford Road, Manchester M13 9PL, UK Contact: Office: (+44-161) 275 4120. Email: geim@manchester.ac.uk. YouTube; Twitter; Facebook ...

  14. Sir John Meurig Thomas.

    Science.gov (United States)

    Thomas, John Meurig

    2013-10-11

    "My greatest achievement has been to combine being a teacher, a researcher, and a popularizer of science for over 50 years. My worst nightmare is to find myself dumbstruck when I am about to give a lecture …︁" This and more about Sir John Meurig Thomas can be found on page 10938. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Screening of snoring with an MP3 recorder.

    Science.gov (United States)

    Kreivi, Hanna-Riikka; Salmi, Tapani; Maasilta, Paula; Bachour, Adel

    2013-03-01

    Snoring patients seeking medical assistance represent a wide range of clinical and sleep study findings from nonsleepy nonapneic snoring to severe obstructive sleep apnea syndrome. The prevalence of snoring is high and it significantly impacts quality of life. Its objective diagnosis usually requires a sleep study. We developed a system to analyze snoring sounds with a Moving Picture Experts Group Layer-3 Audio (MP3) recorder device and present its value in the screening of snoring. We recorded snoring sounds during in-lab polysomnography (PSG) in 200 consecutive patients referred for a suspicion of obstructive sleep apnea. Snoring was recorded during the PSG with two microphones: one attached to the throat and the other to the ceiling; an MP3 device was attached to the patient's collar. Snoring was confirmed when the MP3 acoustic signal exceeded twice the median value of the acoustic signal for the entire recording. Results of the MP3 snoring recording were compared to the snoring recordings from the PSG. MP3 recording proved technically successful for 87% of the patients. The Pearson correlation between PSG snoring and MP3 snoring was highly significant at 0.77 (p MP3 recording device underestimated the snoring time by a mean ± SD of 32 ± 55 min. The recording of snoring with an MP3 device provides reliable information about the patient's snoring.

  16. OpenMP for Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Beyer, J C; Stotzer, E J; Hart, A; de Supinski, B R

    2011-03-15

    OpenMP [13] is the dominant programming model for shared-memory parallelism in C, C++ and Fortran due to its easy-to-use directive-based style, portability and broad support by compiler vendors. Similar characteristics are needed for a programming model for devices such as GPUs and DSPs that are gaining popularity to accelerate compute-intensive application regions. This paper presents extensions to OpenMP that provide that programming model. Our results demonstrate that a high-level programming model can provide accelerated performance comparable to hand-coded implementations in CUDA.

  17. RENAP-MP: national PWR - medium nuclear power plant

    International Nuclear Information System (INIS)

    Meldonian, N.L.; Yamaguchi, M.; Kosaka, N.; Moreira, J.M.L.

    1994-01-01

    In this work are presented the main characteristics of a medium nuclear power plant, named RENAP - MP which has been developed by the Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN - SP) and Coordenadoria para Projetos Especiais (COPESP) from de Brazilian Navy. The study aims at determining the necessary conditions for such a plant complete, in Brazil, technically and economically with other means of thermal power generation, such as coal, gas and oil. Results show that the energy average cost should be around 59 dollars/MWh; the construction time should be less than 5 years in order to reduce financial costs; and the design should emphasize the use of inherently safe technology, in order to reduce substantially the risks of nuclear accidents. It should be pointed out that the nuclear power technology has some environmental and social advantages when compared to hydro and other thermal power technologies, since it does not require flooding of large areas, reduces green house and acid rain effects, and can be located near consumption areas. (author). 11 refs, 5 tabs

  18. Procalcitonin, C-reactive protein and serum lactate dehydrogenase in the diagnosis of bacterial sepsis, SIRS and systemic candidiasis.

    Science.gov (United States)

    Miglietta, Fabio; Faneschi, Maria Letizia; Lobreglio, Giambattista; Palumbo, Claudio; Rizzo, Adriana; Cucurachi, Marco; Portaccio, Gerolamo; Guerra, Francesco; Pizzolante, Maria

    2015-09-01

    The aim of this study was to evaluate procalcitonin (PCT), C-reactive protein (CRP), platelet count (PLT) and serum lactate dehydrogenase (LDH) as early markers for diagnosis of SIRS, bacterial sepsis and systemic candidiasis in intensive care unit (ICU) patients. Based on blood culture results, the patients were divided into a sepsis group (70 patients), a SIRS group (42 patients) and a systemic candidiasis group (33 patients). PCT, CRP, LDH and PLT levels were measured on day 0 and on day 2 from the sepsis symptom onset. PCT levels were higher in Gram negative sepsis than those in Gram positive sepsis, although the P value between the two subgroups is not significant (P=0.095). Bacterial sepsis group had higher PCT and CRP levels compared with the systemic candidiasis group, whereas PLT and LDH levels showed similar levels in these two subgroups. The AUC for PCT (AUC: 0.892, P candidiasis groups (P=0.093 N.S.). In conclusion, PCT can be used as a preliminary marker in the event of clinical suspicion of systemic candidiasis; however, low PCT levels (candidiasis and SIRS groups.

  19. Sir Karl Popper and Education

    Science.gov (United States)

    McNamara, D. R.

    1978-01-01

    Sir Karl Popper is one of England's most distinguished contemporary philosophers and it is surprising that his thought has not permeated and informed educational discussion. This paper suggests that educationists have much to learn from Karl Popper's writings and explores ways in which his ideas can illuminate and advance discussion about…

  20. Thomas, Prof. Sir John Meurig

    Indian Academy of Sciences (India)

    Thomas, Prof. Sir John Meurig FRS. Date of birth: 15 December 1932. Address: Department of Materials Science and, Metallurgy, New Museums Site, 27, Babbage ... Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on the teaching of the theory of evolution more.

  1. Assessment of Mercaptopurine (6MP) Metabolites and 6MP Metabolic Key-Enzymes in Childhood Acute Lymphoblastic Leukemia

    NARCIS (Netherlands)

    Wojtuszkiewicz, A.; Barcelos, A.; Dubbelman, B.; Abreu, R.A. de; Brouwer, C.; Bökkerink, J.P.M.; Haas, V. de; Groot-Kruseman, H. de; Jansen, G.; Kaspers, G.L.; Cloos, J.; Peters, G.J.

    2014-01-01

    Pediatric acute lymphoblastic leukemia (ALL) is treated with combination chemotherapy including mercaptopurine (6MP) as an important component. Upon its uptake, 6MP undergoes a complex metabolism involving many enzymes and active products. The prognostic value of all the factors engaged in this

  2. Constitutive Relation of Engineering Material Based on SIR Model and HAM

    Directory of Open Access Journals (Sweden)

    Haoxiang He

    2014-01-01

    Full Text Available As an epidemic mathematical model, the SIR model represents the transition of the Susceptible, Infected, and Recovered. The profound implication of the SIR model is viewed as the propagation and dynamic evolutionary process of the different internal components and the characteristics in a complex system subject to external effect. The uniaxial stress-strain curve of engineering material represents the basic constitutive relation, which also represents the damage propagation in the units of the damaged member. Hence, a novel dynamic stress-strain model is established based on the SIR model. The analytical solution and the approximate solution for the proposed model are represented according to the homotopy analysis method (HAM, and the relationship of the solution and the size effect and the strain rate is discussed. In addition, an experiment on the size effect of confined concrete is carried out and the solution of SIR model is suitable for simulation. The results show that the mechanical mechanism of the parameters of the uniaxial stress-strain model proposed in this paper reflects the actual characteristics of the materials. The solution of the SIR model can fully and accurately show the change of the mechanical performance and the influence of the size effect and the strain rate.

  3. Extending OpenMP for NUMA Machines

    Directory of Open Access Journals (Sweden)

    John Bircsak

    2000-01-01

    Full Text Available This paper describes extensions to OpenMP that implement data placement features needed for NUMA architectures. OpenMP is a collection of compiler directives and library routines used to write portable parallel programs for shared-memory architectures. Writing efficient parallel programs for NUMA architectures, which have characteristics of both shared-memory and distributed-memory architectures, requires that a programmer control the placement of data in memory and the placement of computations that operate on that data. Optimal performance is obtained when computations occur on processors that have fast access to the data needed by those computations. OpenMP -- designed for shared-memory architectures -- does not by itself address these issues. The extensions to OpenMP Fortran presented here have been mainly taken from High Performance Fortran. The paper describes some of the techniques that the Compaq Fortran compiler uses to generate efficient code based on these extensions. It also describes some additional compiler optimizations, and concludes with some preliminary results.

  4. Numerical simulation system for environmental studies: SPEEDI-MP

    International Nuclear Information System (INIS)

    Nagai, Haruyasu; Chino, Masamichi; Terada, Hiroaki; Harayama, Takaya; Kobayashi, Takuya; Tsuduki, Katsunori; Kim, Keyong-Ok; Furuno, Akiko

    2006-09-01

    A numerical simulation system SPEEDI-MP has been developed to apply for various environmental studies. SPEEDI-MP consists of dynamical models and material transport models for the atmospheric, terrestrial, and oceanic environments, meteorological and geographical database for model inputs, and system utilities for file management, visualization, analysis, etc., using graphical user interfaces (GUIs). As a numerical simulation tool, a model coupling program (model coupler) has been developed. It controls parallel calculations of several models and data exchanges among them to realize the dynamical coupling of the models. A coupled model system for water circulation has been constructed with atmosphere, ocean, wave, hydrology, and land-surface models using the model coupler. System utility GUIs are based on the Web technology, allowing users to manipulate all the functions on the system using their own PCs via the internet. In this system, the source estimation function in the atmospheric transport model can be executed on the grid computer system. Performance tests of the coupled model system for water circulation were also carried out for the flood event at Saudi Arabia in January 2005 and the storm surge case by the hurricane KATRINA in August 2005. (author)

  5. Y-90 microsphere therapy: prevention of adverse events.

    Science.gov (United States)

    Schultz, Cheryl C; Campbell, Janice; Bakalyar, Donovan; Beauvais, Michele; Feng, Wenzheng; Savin, Michael

    2009-08-01

    Thirty-three (33) events that were inconsistent with intended treatment for 471 Y-90 microsphere deliveries were analyzed from 2001 to 2007. Each occurrence was categorized, based on root-cause analysis, as a device/product defect and/or operator error event. Events were further categorized, if there was an adverse outcome, as spill/leak, termination, recatheterization, dose deviation, and/or a regulatory medical event. Of 264 Y-90 Therasphere (MDS Nordion, Ottawa, Ontario, Canada) treatments, 15 events were reported (5.7%). Of 207 Y-90 SIR-Spheres (Sirtex, Wilmington, MA) treatments, 18 events were reported (8.7%). Twenty-five (25) of 33 events (76%) were device/product defects: 73% for Therasphere (11 of 15) and 78% for SIR-Spheres (14 of 18). There were 31 adverse outcomes associated with 33 events: 15 were leaks and/or spills, 9 resulted in termination of the dose administration, 3 resulted in recatheterization for dose compensation, 2 were dose deviations (doses differing from the prescribed between 10% and 20%), and 2 were reported as regulatory medical events. Fifty-five (55) corrective actions were taken: 39 (71%) were related to the manufacturer and 16 (29%) were hospital based. This process of analyzing each event and measuring our outcomes has been effective at minimizing adverse events and improving patient safety.

  6. Compression of surface myoelectric signals using MP3 encoding.

    Science.gov (United States)

    Chan, Adrian D C

    2011-01-01

    The potential of MP3 compression of surface myoelectric signals is explored in this paper. MP3 compression is a perceptual-based encoder scheme, used traditionally to compress audio signals. The ubiquity of MP3 compression (e.g., portable consumer electronics and internet applications) makes it an attractive option for remote monitoring and telemedicine applications. The effects of muscle site and contraction type are examined at different MP3 encoding bitrates. Results demonstrate that MP3 compression is sensitive to the myoelectric signal bandwidth, with larger signal distortion associated with myoelectric signals that have higher bandwidths. Compared to other myoelectric signal compression techniques reported previously (embedded zero-tree wavelet compression and adaptive differential pulse code modulation), MP3 compression demonstrates superior performance (i.e., lower percent residual differences for the same compression ratios).

  7. Scientific objectives and selection of targets for the SMART-1 Infrared Spectrometer (SIR)

    Science.gov (United States)

    Basilevsky, A. T.; Keller, H. U.; Nathues, A.; Mall, U.; Hiesinger, H.; Rosiek, M.

    2004-12-01

    The European SMART-1 mission to the Moon, primarily a testbed for innovative technologies, was launched in September 2003 and will reach the Moon in 2005. On board are several scientific instruments, including the point-spectrometer SMART-1 Infrared Spectrometer (SIR). Taking into account the capabilities of the SMART-1 mission and the SIR instrument in particular, as well as the open questions in lunar science, a selection of targets for SIR observations has been compiled. SIR can address at least five topics: (1) Surface/regolith processes; (2) Lunar volcanism; (3) Lunar crust structure; (4) Search for spectral signatures of ices at the lunar poles; and (5) Ground truth and study of geometric effects on the spectral shape. For each topic we will discuss specific observation modes, necessary to achieve our scientific goals. The majority of SIR targets will be observed in the nadir-tracking mode. More than 100 targets, which require off-nadir pointing and off-nadir tracking, are planned. It is expected that results of SIR observations will significantly increase our understanding of the Moon. Since the exact arrival date and the orbital parameters of the SMART-1 spacecraft are not known yet, a more detailed planning of the scientific observations will follow in the near future.

  8. King, Prof. Sir David Anthony

    Indian Academy of Sciences (India)

    Elected: 1998 Honorary. King, Prof. Sir David Anthony Sc.D., FRS. Date of birth: 12 August 1939. Address: Chief Scientific Adivser & Head, Office of Science and Innovation, London SW1H 0ET, U.K.. Contact: Office: (+44-020) 7215 3821. Fax: (+44-020) 7215 0314. Email: mpst.king@dti.gsi.gov.uk, dak10@cus.cam.ac.uk.

  9. Mp1p Is a Virulence Factor in Talaromyces (Penicillium marneffei.

    Directory of Open Access Journals (Sweden)

    Patrick C Y Woo

    2016-08-01

    Full Text Available Talaromyces marneffei is an opportunistic dimorphic fungus prevalent in Southeast Asia. We previously demonstrated that Mp1p is an immunogenic surface and secretory mannoprotein of T. marneffei. Since Mp1p is a surface protein that can generate protective immunity, we hypothesized that Mp1p and/or its homologs are virulence factors.We examined the pathogenic roles of Mp1p and its homologs in a mouse model. All mice died 21 and 30 days after challenge with wild-type T. marneffei PM1 and MP1 complemented mutant respectively. None of the mice died 60 days after challenge with MP1 knockout mutant (P<0.0001. Seventy percent of mice died 60 days after challenge with MP1 knockdown mutant (P<0.0001. All mice died after challenge with MPLP1 to MPLP13 knockdown mutants, suggesting that only Mp1p plays a significant role in virulence. The mean fungal loads of PM1 and MP1 complemented mutant in the liver, lung, kidney and spleen were significantly higher than those of the MP1 knockout mutant. Similarly, the mean load of PM1 in the liver, lung and spleen were significantly higher than that of the MP1 knockdown mutant. Histopathological studies showed an abundance of yeast in the kidney, spleen, liver and lung with more marked hepatic and splenic necrosis in mice challenged with PM1 compared to MP1 knockout and MP1 knockdown mutants. Likewise, a higher abundance of yeast was observed in the liver and spleen of mice challenged with MP1 complemented mutant compared to MP1 knockout mutant. PM1 and MP1 complemented mutant survived significantly better than MP1 knockout mutant in macrophages at 48 hours (P<0.01 post-infection. The mean fungal counts of Pichia pastoris GS115-MP1 in the liver (P<0.001 and spleen (P<0.05 of mice were significantly higher than those of GS115 at 24 hours post-challenge.Mp1p is a key virulence factor of T. marneffei. Mp1p mediates virulence by improving the survival of T. marneffei in macrophages.

  10. A Multiprogramming Aware OpenMP Implementation

    Directory of Open Access Journals (Sweden)

    Vasileios K. Barekas

    2003-01-01

    Full Text Available In this work, we present an OpenMP implementation suitable for multiprogrammed environments on Intel-based SMP systems. This implementation consists of a runtime system and a resource manager, while we use the NanosCompiler to transform OpenMP-coded applications into code with calls to our runtime system. The resource manager acts as the operating system scheduler for the applications built with our runtime system. It executes a custom made scheduling policy to distribute the available physical processors to the active applications. The runtime system cooperates with the resource manager in order to adapt each application's generated parallelism to the number of processors allocated to it, according to the resource manager scheduling policy. We use the OpenMP version of the NAS Parallel Benchmark suite in order to evaluate the performance of our implementation. In our experiments we compare the performance of our implementation with that of a commercial OpenMP implementation. The comparison proves that our approach performs better both on a dedicated and on a heavily multiprogrammed environment.

  11. Structural, mechanical, and electronic properties of TaB2, TaB, IrB2, and IrB: First-principle calculations

    International Nuclear Information System (INIS)

    Zhao Wenjie; Wang Yuanxu

    2009-01-01

    First-principle calculations were performed to investigate the structural, elastic, and electronic properties of TaB 2 , TaB, IrB 2 , and IrB. The calculated equilibrium structural parameters, shear modulus, and Young's modulus of TaB 2 are well consistent with the available experimental data, and TaB 2 with P6/mmm space group has stronger directional bonding between ions than WB 2 , OsB 2 , IrN 2 , and PtN 2 . For TaB 2 , the hexagonal P6/mmm structure is more stable than the orthorhombic Pmmn one, while for IrB 2 the orthorhombic Pmmn structure is the most stable one. The high shear modulus of P6/mmm phase TaB 2 is mainly due to the strong covalent π-bonding of B-hexagon in the (0001) plane. Such a B-hexagon network can strongly resist against an applied [112-bar0] (0001) shear deformation. Correlation between the hardness and the elastic constants of TaB 2 was discussed. The band structure shows that P6/mmm phase TaB 2 and Pmmn phase IrB 2 are both metallic. The calculations show that both TaB and IrB are elastically stable with the hexagonal P6 3 /mmc structure. - Elastic constant c 44 of TaB 2 is calculated to be 235 GPa. This value is exceptionally high, exceeding those of WB 2 , OsB 2 , WB 4 , OsN 2 , IrN 2 , and PtN 2 .

  12. Search for the lepton-flavor violating decays $B^0_s \\rightarrow e^{\\pm}\\mu^{\\mp}$ and $B^0 \\rightarrow e^{\\pm} \\mu^{\\mp}$

    CERN Document Server

    Aaij, R.; Adinolfi, M.; Adrover, C.; Affolder, A.; Ajaltouni, Z.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves Jr, A.A.; Amato, S.; Amerio, S.; Amhis, Y.; Anderlini, L.; Anderson, J.; Andreassen, R.; Andrews, J.E.; Appleby, R.B.; Aquines Gutierrez, O.; Archilli, F.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J.J.; Baesso, C.; Balagura, V.; Baldini, W.; Barlow, R.J.; Barschel, C.; Barsuk, S.; Barter, W.; Bauer, Th.; Bay, A.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Belogurov, S.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bettler, M.-O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Bizzeti, A.; Bjørnstad, P.M.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borgia, A.; Bowcock, T.J.V.; Bowen, E.; Bozzi, C.; Brambach, T.; van den Brand, J.; Bressieux, J.; Brett, D.; Britsch, M.; Britton, T.; Brook, N.H.; Brown, H.; Burducea, I.; Bursche, A.; Busetto, G.; Buytaert, J.; Cadeddu, S.; Callot, O.; Calvi, M.; Calvo Gomez, M.; Camboni, A.; Campana, P.; Campora Perez, D.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carranza-Mejia, H.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Castillo Garcia, L.; Cattaneo, M.; Cauet, Ch.; Cenci, R.; Charles, M.; Charpentier, Ph.; Chen, P.; Chiapolini, N.; Chrzaszcz, M.; Ciba, K.; Cid Vidal, X.; Ciezarek, G.; Clarke, P.E.L.; Clemencic, M.; Cliff, H.V.; Closier, J.; Coca, C.; Coco, V.; Cogan, J.; Cogneras, E.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Couturier, B.; Cowan, G.A.; Craik, D.C.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; David, P.; David, P.N.Y.; Davis, A.; De Bonis, I.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J.M.; De Paula, L.; De Silva, W.; De Simone, P.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Déléage, N.; Derkach, D.; Deschamps, O.; Dettori, F.; Di Canto, A.; Dijkstra, H.; Dogaru, M.; Donleavy, S.; Dordei, F.; Dosil Suárez, A.; Dossett, D.; Dovbnya, A.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; van Eijk, D.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Falabella, A.; Färber, C.; Fardell, G.; Farinelli, C.; Farry, S.; Fave, V.; Ferguson, D.; Fernandez Albor, V.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fitzpatrick, C.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Furcas, S.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gandelman, M.; Gandini, P.; Gao, Y.; Garofoli, J.; Garosi, P.; Garra Tico, J.; Garrido, L.; Gaspar, C.; Gauld, R.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gibson, V.; Giubega, L.; Gligorov, V.V.; Göbel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gordon, H.; Grabalosa Gándara, M.; Graciani Diaz, R.; Granado Cardoso, L.A.; Graugés, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grünberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S.C.; Hall, S.; Hamilton, B.; Hampson, T.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S.T.; Harrison, J.; Hartmann, T.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Hernando Morata, J.A.; van Herwijnen, E.; Hicheur, A.; Hicks, E.; Hill, D.; Hoballah, M.; Hombach, C.; Hopchev, P.; Hulsbergen, W.; Hunt, P.; Huse, T.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Iakovenko, V.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jans, E.; Jaton, P.; Jawahery, A.; Jing, F.; John, M.; Johnson, D.; Jones, C.R.; Joram, C.; Jost, B.; Kaballo, M.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T.M.; Kenyon, I.R.; Ketel, T.; Keune, A.; Khanji, B.; Kochebina, O.; Komarov, I.; Koopman, R.F.; Koppenburg, P.; Korolev, M.; Kozlinskiy, A.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucharczyk, M.; Kudryavtsev, V.; Kvaratskheliya, T.; La Thi, V.N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R.W.; Lanciotti, E.; Lanfranchi, G.; Langenbruch, C.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.-P.; Lefèvre, R.; Leflat, A.; Lefrançois, J.; Leo, S.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y.; Li Gioi, L.; Liles, M.; Lindner, R.; Linn, C.; Liu, B.; Liu, G.; Lohn, S.; Longstaff, I.; Lopes, J.H.; Lopez-March, N.; Lu, H.; Lucchesi, D.; Luisier, J.; Luo, H.; Machefert, F.; Machikhiliyan, I.V.; Maciuc, F.; Maev, O.; Malde, S.; Manca, G.; Mancinelli, G.; Maratas, J.; Marconi, U.; Marino, P.; Märki, R.; Marks, J.; Martellotti, G.; Martens, A.; Martín Sánchez, A.; Martinelli, M.; Martinez Santos, D.; Martins Tostes, D.; Massafferri, A.; Matev, R.; Mathe, Z.; Matteuzzi, C.; Maurice, E.; Mazurov, A.; Mc Skelly, B.; McCarthy, J.; McNab, A.; McNulty, R.; Meadows, B.; Meier, F.; Meissner, M.; Merk, M.; Milanes, D.A.; Minard, M.-N.; Molina Rodriguez, J.; Monteil, S.; Moran, D.; Morawski, P.; Mordà, A.; Morello, M.J.; Mountain, R.; Mous, I.; Muheim, F.; Müller, K.; Muresan, R.; Muryn, B.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nasteva, I.; Needham, M.; Neubert, S.; Neufeld, N.; Nguyen, A.D.; Nguyen, T.D.; Nguyen-Mau, C.; Nicol, M.; Niess, V.; Niet, R.; Nikitin, N.; Nikodem, T.; Nomerotski, A.; Novoselov, A.; Oblakowska-Mucha, A.; Obraztsov, V.; Oggero, S.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Orlandea, M.; Otalora Goicochea, J.M.; Owen, P.; Oyanguren, A.; Pal, B.K.; Palano, A.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Parkes, C.; Parkinson, C.J.; Passaleva, G.; Patel, G.D.; Patel, M.; Patrick, G.N.; Patrignani, C.; Pavel-Nicorescu, C.; Pazos Alvarez, A.; Pellegrino, A.; Penso, G.; Pepe Altarelli, M.; Perazzini, S.; Perez Trigo, E.; Pérez-Calero Yzquierdo, A.; Perret, P.; Perrin-Terrin, M.; Pescatore, L.; Pessina, G.; Petridis, K.; Petrolini, A.; Phan, A.; Picatoste Olloqui, E.; Pietrzyk, B.; Pilař, T.; Pinci, D.; Playfer, S.; Plo Casasus, M.; Polci, F.; Polok, G.; Poluektov, A.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Powell, A.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Punzi, G.; Qian, W.; Rademacker, J.H.; Rakotomiaramanana, B.; Rangel, M.S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Redford, S.; Reid, M.M.; dos Reis, A.C.; Ricciardi, S.; Richards, A.; Rinnert, K.; Rives Molina, V.; Roa Romero, D.A.; Robbe, P.; Roberts, D.A.; Rodrigues, E.; Rodriguez Perez, P.; Roiser, S.; Romanovsky, V.; Romero Vidal, A.; Rouvinet, J.; Ruf, T.; Ruffini, F.; Ruiz, H.; Ruiz Valls, P.; Sabatino, G.; Saborido Silva, J.J.; Sagidova, N.; Sail, P.; Saitta, B.; Salustino Guimaraes, V.; Salzmann, C.; Sanmartin Sedes, B.; Sannino, M.; Santacesaria, R.; Santamarina Rios, C.; Santovetti, E.; Sapunov, M.; Sarti, A.; Satriano, C.; Satta, A.; Savrie, M.; Savrina, D.; Schaack, P.; Schiller, M.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmidt, B.; Schneider, O.; Schopper, A.; Schune, M.-H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Seco, M.; Semennikov, A.; Senderowska, K.; Sepp, I.; Serra, N.; Serrano, J.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shatalov, P.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, O.; Shevchenko, V.; Shires, A.; Silva Coutinho, R.; Sirendi, M.; Skwarnicki, T.; Smith, N.A.; Smith, E.; Smith, J.; Smith, M.; Sokoloff, M.D.; Soler, F.J.P.; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Sparkes, A.; Spradlin, P.; Stagni, F.; Stahl, S.; Steinkamp, O.; Stevenson, S.; Stoica, S.; Stone, S.; Storaci, B.; Straticiuc, M.; Straumann, U.; Subbiah, V.K.; Sun, L.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szczypka, P.; Szumlak, T.; T'Jampens, S.; Teklishyn, M.; Teodorescu, E.; Teubert, F.; Thomas, C.; Thomas, E.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Tolk, S.; Tonelli, D.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Tran, M.T.; Tresch, M.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Ubeda Garcia, M.; Ukleja, A.; Urner, D.; Ustyuzhanin, A.; Uwer, U.; Vagnoni, V.; Valenti, G.; Vallier, A.; Van Dijk, M.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vázquez Sierra, C.; Vecchi, S.; Velthuis, J.J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Vieira, D.; Vilasis-Cardona, X.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voß, C.; Voss, H.; Waldi, R.; Wallace, C.; Wallace, R.; Wandernoth, S.; Wang, J.; Ward, D.R.; Watson, N.K.; Webber, A.D.; Websdale, D.; Whitehead, M.; Wicht, J.; Wiechczynski, J.; Wiedner, D.; Wiggers, L.; Wilkinson, G.; Williams, M.P.; Williams, M.; Wilson, F.F.; Wimberley, J.; Wishahi, J.; Witek, M.; Wotton, S.A.; Wright, S.; Wu, S.; Wyllie, K.; Xie, Y.; Xing, Z.; Yang, Z.; Young, R.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhang, F.; Zhang, L.; Zhang, W.C.; Zhang, Y.; Zhelezov, A.; Zhokhov, A.; Zhong, L.; Zvyagin, A.

    2013-01-01

    A search for the lepton-flavour violating decays $B^0_s \\rightarrow e^{\\pm}\\mu^{\\mp}$ and $B^0 \\rightarrow e^{\\pm} \\mu^{\\mp}$ is performed with a data sample, corresponding to an integrated luminosity of 1.0 fb$^{-1}$ of $pp$ collisions at $\\sqrt{s} = 7$, TeV, collected by the LHCb experiment. The observed number of $B^0_s \\to e^{\\pm} \\mu^{\\mp}$ and $B^0 \\to e^{\\pm} \\mu^{\\mp}$ candidates is consistent with background expectations. Upper limits on the branching fractions of both decays are determined to be $BR(B^0_s \\to e^{\\pm} \\mu^{\\mp} 107$ TeV/c$^2$ and $M_{\\rm LQ} (B^0 \\to e^{\\pm} \\mu^{\\mp}) > 126$ TeV/c$^2$ at 95% C.L., and are a factor of two higher than the previous bounds.

  13. 90Sr content in 90Y-labeled SIR-spheres and Zevalin.

    Science.gov (United States)

    Metyko, John; Erwin, William; Poston, John; Jimenez, Sandra

    2014-11-01

    Three different 90Y internally administered radionuclide therapies are currently used in both standard-of-care and clinical trial procedures atMD Anderson Cancer Center. TheraSphere and SIR-Spheres therapies utilize 90Y-labeled microspheres, while Zevalin is an 90Y-labeled radioimmunotherapeutic agent. Several publications have indicated radionuclidic impurities resulting from 90Y production methods. The 90Y in SIR-Spheres and Zevalin are produced from a 90Sr/90Y generator, which leaves measurable quantities of 90Sr in the final product. TheraSphere 90Y is produced in a nuclear reactor which results in a large number of impurities, most notably 88Y and 91Y. Product information sheets reference these impurities with specific limits given. These limits represent a tiny fraction of the total product activity, and in the case of TheraSphere and SIR-Spheres gamma-emitting impurities, this has been verified in the literature. An analysis of 90Sr impurities in SIR-Spheres and Zevalin is presented in this paper. Impurity quantities were found to be within the vendors’ documented limits.

  14. Incidence of tinnitus in mp3 player users.

    Science.gov (United States)

    Figueiredo, Ricardo Rodrigues; Azevedo, Andreia Aparecida de; Oliveira, Patrícia Mello de; Amorim, Sandro Pereira Vasconcellos; Rios, Artur Guedes; Baptista, Vanderlei

    2011-06-01

    Exposure to loud noise is one of the main causes of tinnitus. To analyze the incidence of tinnitus in mp3 player users and non-users. One hundred subjects aged from 15 to 30 years were enrolled, 54 of them were regular mp3 player users and 46 were not. Patients with continuous tinnitus for at least 6 months completed the Tinnitus Handicap Inventory (THI) and were tested with high frequency audiometry and transient-evoked otoacoustic emissions (TAOE). A cross-sectional cohort study. The incidence of tinnitus in non-users was about 8 %; in mp3 player users it was about 28 %, a statistically significant difference. Hearing thresholds at 8 kHz were significantly higher in tinnitus patients that used mp3 portable players.TAOE were reduced at 2 kHz in the users group. No statistically significant difference was found in the THI scores between the two groups. Tinnitus was more frequent in teenagers and young adults who regularly listen to mp3 music in players. Moreover, the incidence of tinnitus among mp3 player users was associated with higher hearing thresholds at 8 kHz and lower TOAE at 2 kHz.

  15. Implementation of MPICH on Top of MP_Lite

    Energy Technology Data Exchange (ETDEWEB)

    Selvarajan, Shoba [Iowa State Univ., Ames, IA (United States)

    2002-01-01

    The goal of this thesis is to develop a new Channel Interface device for the MPICH Implementation of the MPI (Message Passing Interface) standard using MP_Lite. MP_Lite is a lightweight message-passing library that is not a full MPI implementation, but offers high performance MPICH (Message Passing Interface CHameleon) is a full implementation of the MPI standard that has the p4 library as the underlying communication device for TCP/IP networks. By integrating MP_Lite as a Channel Interface device in MPICH, a parallel programmer can utilize the full MPI implementation of MPICH as well as the high bandwidth offered by MP_Lite. There are several layers in the MPICH library where one can tie a new device. The Channel Interface is the lowest layer that requires very few functions to add a new device. By attaching MP_Lite to MPICH at the lowest level, the Channel Interface, almost all of the performance of the MP_Lite library can be delivered to the applications using MPICH. MP_Lite can be implemented either as a blocking or a non-blocking Channel Interface device. The performance was measured on two separate test clusters, the PC and the Alpha miniclusters, having Gigabit Ethernet connections. The PC cluster has two 1.8 GHz Pentium 4 PCs and the Alpha cluster has two 500 MHz Compaq DS20 workstations. Different network interface cards like Netgear, TrendNet and SysKonnect Gigabit Ethernet cards were used for the measurements. Both the blocking and non-blocking MPICH-MP_Lite Channel Interface devices perform close to raw TCP, whereas a performance loss of 25-30% is seen in the MPICH-p4 Channel Interface device for larger messages. The superior performance offered by the MPICH-MP_Lite device compared to the MPICH-p4 device can be easily seen on the SysKonnect cards using jumbo frames. The throughput curve also improves considerably by increasing the Eager/Rendezvous threshold.

  16. A Case for Including Transactions in OpenMP

    Energy Technology Data Exchange (ETDEWEB)

    Wong, M; Bihari, B L; de Supinski, B R; Wu, P; Michael, M; Liu, Y; Chen, W

    2010-01-25

    Transactional Memory (TM) has received significant attention recently as a mechanism to reduce the complexity of shared memory programming. We explore the potential of TM to improve OpenMP applications. We combine a software TM (STM) system to support transactions with an OpenMP implementation to start thread teams and provide task and loop-level parallelization. We apply this system to two application scenarios that reflect realistic TM use cases. Our results with this system demonstrate that even with the relatively high overheads of STM, transactions can outperform OpenMP critical sections by 10%. Overall, our study demonstrates that extending OpenMP to include transactions would ease programming effort while allowing improved performance.

  17. MP Joint Arthritis

    Science.gov (United States)

    ... All Topics A-Z Videos Infographics Symptom Picker Anatomy Bones Joints Muscles Nerves Vessels Tendons About Hand Surgery What is a Hand Surgeon? What is a Hand Therapist? Media Find a Hand Surgeon Home Anatomy MP Joint Arthritis Email to a friend * required ...

  18. Samsung Galaxy Tab S for dummies

    CERN Document Server

    Gookin, Dan

    2015-01-01

    Explore your Galaxy Tab S with an expert tour guide at your side Samsung Galaxy Tab S For Dummies is a user-friendly guide to getting the most out of your new tablet. You'll discover how different the tablet experience is from the desktop, laptop, or smartphone, and learn how to take advantage of everything your Galaxy Tab S has to offer. This entertaining guide walks you through each feature one by one, helping you learn exactly what your tablet can do for you. With everything from reading to playing games and surfing the Internet, you will learn how to be productive and have fun, too! Nav

  19. Whither Sir William?

    Directory of Open Access Journals (Sweden)

    Stephen J. Greenberg, MSLS, PhD

    2017-04-01

    Full Text Available There are times when something is simply so familiar that we can no longer see it at all. It can be a story, or a concept, or even a flesh-and-blood person. Familiarity breeds not only contempt, but a kind of invisibility as well. For too many of us, such is the case with Sir William Osler. In his time (1849–1919, many considered him to be one of the greatest practitioners, teachers, and writers ever in the field of medicine. He was instrumental in the founding of the Medical Library Association (MLA and was elected its second president.

  20. SIRS Digues 2.0: A Cooperative Software For Levees Management

    Directory of Open Access Journals (Sweden)

    Moins Isabelle

    2016-01-01

    Full Text Available SIRS Digues is a computing tool that makes informations on levees more durable and accessible in order to enhance their management. The first version of the software, which was IRSTEA’s initiative, was deployed in 2004. The second version was released in 2015. This article aims at pointing out the innovative aspects of this last version. They concern thematic and functionalities, computing technics and architecture, and last but not least, the business model chosen in order to build a long lasting software. The software’s kernel is sketched to propose a general description of levees: it focuses on description of the levees and linked objects, on disorders that affects them, on works... Most of these topics were already broached by the first version. The kernel of the version 2 may be extended using optional thematic modules. These modules concern: vegetation monitoring, reporting (in coherence with current French regulatory requirements, riverbanks, riverbed... Main functionnalities perfomed by SIRS Digues V1 and V2 are : data structuring and centralisation, quick access to relevant data, reporting and mapping, etc. SIRS Digues 2.0 updates and improves already existing functionalities of the first version. SIRS Digues V2 relies on an documentoriented NoSQL database, CouchDB, and on geospatial libraries, Geotoolkit and Apache-SIS. SIRS Digues V2 was released with a copyleft license. Copyrights belong to the French levees managers’ society, “France Digues”, which acts as a cooperative. Members put their heads together in order to gather their financial capacities and fund software development. France Digues has got the technical and thematic expertise and supply various services to the members. This business model aims to ensure accessibility, durability and adaptability of the software.

  1. C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.

    Science.gov (United States)

    Chiang, Wei-Chung; Tishkoff, Daniel X; Yang, Bo; Wilson-Grady, Joshua; Yu, Xiaokun; Mazer, Travis; Eckersdorff, Mark; Gygi, Steven P; Lombard, David B; Hsu, Ao-Lin

    2012-09-01

    FoxO transcription factors and sirtuin family deacetylases regulate diverse biological processes, including stress responses and longevity. Here we show that the Caenorhabditis elegans sirtuin SIR-2.4--homolog of mammalian SIRT6 and SIRT7 proteins--promotes DAF-16-dependent transcription and stress-induced DAF-16 nuclear localization. SIR-2.4 is required for resistance to multiple stressors: heat shock, oxidative insult, and proteotoxicity. By contrast, SIR-2.4 is largely dispensable for DAF-16 nuclear localization and function in response to reduced insulin/IGF-1-like signaling. Although acetylation is known to regulate localization and activity of mammalian FoxO proteins, this modification has not been previously described on DAF-16. We find that DAF-16 is hyperacetylated in sir-2.4 mutants. Conversely, DAF-16 is acetylated by the acetyltransferase CBP-1, and DAF-16 is hypoacetylated and constitutively nuclear in response to cbp-1 inhibition. Surprisingly, a SIR-2.4 catalytic mutant efficiently rescues the DAF-16 localization defect in sir-2.4 null animals. Acetylation of DAF-16 by CBP-1 in vitro is inhibited by either wild-type or mutant SIR-2.4, suggesting that SIR-2.4 regulates DAF-16 acetylation indirectly, by preventing CBP-1-mediated acetylation under stress conditions. Taken together, our results identify SIR-2.4 as a critical regulator of DAF-16 specifically in the context of stress responses. Furthermore, they reveal a novel role for acetylation, modulated by the antagonistic activities of CBP-1 and SIR-2.4, in modulating DAF-16 localization and function.

  2. Variation in a surface-exposed region of the Mycoplasma pneumoniae P40 protein as a consequence of homologous DNA recombination between RepMP5 elements.

    Science.gov (United States)

    Spuesens, Emiel B M; van de Kreeke, Nick; Estevão, Silvia; Hoogenboezem, Theo; Sluijter, Marcel; Hartwig, Nico G; van Rossum, Annemarie M C; Vink, Cornelis

    2011-02-01

    Mycoplasma pneumoniae is a human pathogen that causes a range of respiratory tract infections. The first step in infection is adherence of the bacteria to the respiratory epithelium. This step is mediated by a specialized organelle, which contains several proteins (cytadhesins) that have an important function in adherence. Two of these cytadhesins, P40 and P90, represent the proteolytic products from a single 130 kDa protein precursor, which is encoded by the MPN142 gene. Interestingly, MPN142 contains a repetitive DNA element, termed RepMP5, of which homologues are found at seven other loci within the M. pneumoniae genome. It has been hypothesized that these RepMP5 elements, which are similar but not identical in sequence, recombine with their counterpart within MPN142 and thereby provide a source of sequence variation for this gene. As this variation may give rise to amino acid changes within P40 and P90, the recombination between RepMP5 elements may constitute the basis of antigenic variation and, possibly, immune evasion by M. pneumoniae. To investigate the sequence variation of MPN142 in relation to inter-RepMP5 recombination, we determined the sequences of all RepMP5 elements in a collection of 25 strains. The results indicate that: (i) inter-RepMP5 recombination events have occurred in seven of the strains, and (ii) putative RepMP5 recombination events involving MPN142 have induced amino acid changes in a surface-exposed part of the P40 protein in two of the strains. We conclude that recombination between RepMP5 elements is a common phenomenon that may lead to sequence variation of MPN142-encoded proteins.

  3. NUHOMS registered - MP197 transport cask

    International Nuclear Information System (INIS)

    Shih, P.; Sicard, D.; Michels, L.

    2004-01-01

    The NUHOMS registered -MP197 cask is an optimized transport design which can be loaded in the spent fuel pool (wet loading) or loaded the canister from the NUHOMS concrete modules at the ISFSI site. With impact limiters attached, the package can be transported within the states or world-wide. The NUHOMS registered -MP197 packaging can be used to transport either BWR or PWR canisters. The NUHOMS registered -MP197 cask is designed to the ASME B and PV Code and meets the requirements of Section III, Division 3 for Transport Packaging. The cask with impact limiters has undergone drop testing to verify the calculated g loadings during the 9m drops. The test showed good correlation with analytical results and demonstrate that the impact limiters stay in place and protect the package and fuel during the hypothetical accidents

  4. SirT1—A Sensor for Monitoring Self-Renewal and Aging Process in Retinal Stem Cells

    Directory of Open Access Journals (Sweden)

    Chi-Hsien Peng

    2010-06-01

    Full Text Available Retinal stem cells bear potency of proliferation, self-renewal, and differentiation into many retinal cells. Utilizing appropriate sensors one can effectively detect the self-renewal and aging process abilities. Silencing information regulator (SirT1, a member of the sirtuin family, is a NAD-dependent histone deacetylase and an essential mediator for longevity in normal cells by calorie restriction. We firstly investigate the SirT1 mRNA expression in retinal stem cells from rats and 19 human eyes of different ages. Results revealed that SirT1 expression was significantly decreased in in vivo aged eyes, associated with poor self-renewal abilities. Additionally, SirT1 mRNA levels were dose-dependently increased in resveratrol- treated retinal stem cells. The expression of SirT1 on oxidative stress-induced damage was significantly decreased, negatively correlated with the level of intracellular reactive oxygen species production. Treatment with resveratrol could effectively further reduce oxidative stress induced by H2O2 treatment in retinal stem cells. Importantly, the anti-oxidant effects of resveratrol in H2O2-treated retinal stem cells were significantly abolished by knockdown of SirT1 expression (sh-SirT1. SirT1 expression provides a feasible sensor in assessing self-renewal and aging process in retinal stem cells. Resveratrol can prevent reactive oxygen species-induced damages via increased retinal SirT1 expression.

  5. Sir Charles Scott Sherrington (1857–1952)

    Indian Academy of Sciences (India)

    Twentieth century bore witness to remarkable scientists whohave advanced our understanding of the brain. Among them,Sir Charles Scott Sherrington's ideas about the way in whichthe central nervous system operates has continuing relevanceeven today. He received honorary doctorates from twentytwouniversities and ...

  6. Sir Charles Scott Sherrington (1857–1952)

    Indian Academy of Sciences (India)

    2016-08-26

    Aug 26, 2016 ... Twentieth century bore witness to remarkable scientists whohave advanced our understanding of the brain. Among them,Sir Charles Scott Sherrington's ideas about the way in whichthe central nervous system operates has continuing relevanceeven today. He received honorary doctorates from ...

  7. Sir Ronald Ross and the Malarial Parasite

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 7. Sir Ronald Ross and the Malarial Parasite - Discovery of its Route - From Man to Mosquito and Back. Shobhona Sharma. General Article Volume 11 Issue 7 July 2006 pp 4-13 ...

  8. Sir Isaac Newton

    Directory of Open Access Journals (Sweden)

    E. A. Venter

    1964-03-01

    Full Text Available Die geweldige oplewing van die Christelike wetenskaps- gedagte in ons geeslose tyd, is ongetwyfeld ’n haas onverklaar- bare verskynsel. Dwarsdeur die eeue het Christene ook wetenskap beoefen saam met ongelowiges, maar dit was eers in ons leeftyd dat die principia van die Christelike religie ook vrugbaar gemaak is vir die wetenskapsbeoefening. In hierdie verband sal die name van Dooyeweerd, Vollenhoven, Stoker e.a. steeds met eer vermeld word. Natuurlik het belydende Christene ook voorheen wel deeglik saamgewerk aan die gebou van die wetenskap. Die intieme verband tussen religie, wysbegeerte en wetenskaps­ beoefening is toe egter nog nie suiwer ingesien nie. Uit hier­ die tydperk dateer die arbeid van sir Isaac Newton.

  9. Implementation of MP_Lite for the VI Architecture

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Weiyi [Iowa State Univ., Ames, IA (United States)

    2001-01-01

    MP_Lite is a light weight message-passing library designed to deliver the maximum performance to applications in a portable and user friendly manner. The Virtual Interface (VI) architecture is a user-level communication protocol that bypasses the operating system to provide much better performance than traditional network architectures. By combining the high efficiency of MP_Lite and high performance of the VI architecture, they are able to implement a high performance message-passing library that has much lower latency and better throughput. The design and implementation of MP_Lite for M-VIA, which is a modular implementation of the VI architecture on Linux, is discussed in this thesis. By using the eager protocol for sending short messages, MP_Lite M-VIA has much lower latency on both Fast Ethernet and Gigabit Ethernet. The handshake protocol and RDMA mechanism provides double the throughput that MPICH can deliver for long messages. MP_Lite M-VIA also has the ability to channel-bonding multiple network interface cards to increase the potential bandwidth between nodes. Using multiple Fast Ethernet cards can double or even triple the maximum throughput without increasing the cost of a PC cluster greatly.

  10. Piles, tabs and overlaps in navigation among documents

    DEFF Research Database (Denmark)

    Jakobsen, Mikkel Rønne; Hornbæk, Kasper

    2010-01-01

    Navigation among documents is a frequent, but ill supported activity. Overlapping or tabbed documents are widespread, but they offer limited visibility of their content. We explore variations on navigation support: arranging documents with tabs, as overlapping windows, and in piles. In an experim......Navigation among documents is a frequent, but ill supported activity. Overlapping or tabbed documents are widespread, but they offer limited visibility of their content. We explore variations on navigation support: arranging documents with tabs, as overlapping windows, and in piles....... In an experiment we compared 11 participants’ navigation with these variations and found strong task effects. Overall, overlapping windows were preferred and their structured layout worked well with some tasks. Surprisingly, tabbed documents were efficient in tasks requiring simply finding a document. Piled...... on document navigation and its support by piling....

  11. Analysis of histological findings obtained combining US/mp-MRI fusion-guided biopsies with systematic US biopsies: mp-MRI role in prostate cancer detection and false negative.

    Science.gov (United States)

    Faiella, Eliodoro; Santucci, Domiziana; Greco, Federico; Frauenfelder, Giulia; Giacobbe, Viola; Muto, Giovanni; Zobel, Bruno Beomonte; Grasso, Rosario Francesco

    2018-02-01

    To evaluate the diagnostic accuracy of mp-MRI correlating US/mp-MRI fusion-guided biopsy with systematic random US-guided biopsy in prostate cancer diagnosis. 137 suspected prostatic abnormalities were identified on mp-MRI (1.5T) in 96 patients and classified according to PI-RADS score v2. All target lesions underwent US/mp-MRI fusion biopsy and prostatic sampling was completed by US-guided systematic random 12-core biopsies. Histological analysis and Gleason score were established for all the samples, both target lesions defined by mp-MRI, and random biopsies. PI-RADS score was correlated with the histological results, divided in three groups (benign tissue, atypia and carcinoma) and with Gleason groups, divided in four categories considering the new Grading system of the ISUP 2014, using t test. Multivariate analysis was used to correlate PI-RADS and Gleason categories to PSA level and abnormalities axial diameter. When the random core biopsies showed carcinoma (mp-MRI false-negatives), PSA value and lesions Gleason median value were compared with those of carcinomas identified by mp-MRI (true-positives), using t test. There was statistically significant difference between PI-RADS score in carcinoma, atypia and benign lesions groups (4.41, 3.61 and 3.24, respectively) and between PI-RADS score in Gleason  7 group (4.14 and 4.79, respectively). mp-MRI performance was more accurate for lesions > 15 mm and in patients with PSA > 6 ng/ml. In systematic sampling, 130 (11.25%) mp-MRI false-negative were identified. There was no statistic difference in Gleason median value (7.0 vs 7.06) between this group and the mp-MRI true-positives, but a significant lower PSA median value was demonstrated (7.08 vs 7.53 ng/ml). mp-MRI remains the imaging modality of choice to identify PCa lesions. Integrating US-guided random sampling with US/mp-MRI fusion target lesions sampling, 3.49% of false-negative were identified.

  12. Sir Sayyid Ahmed Kahn's History of the Bijnor Rebellion, Translated with Notes and Introduction. South Asia Series, Occasional Paper No. 17.

    Science.gov (United States)

    Michigan State Univ., East Lansing. Asian Studies Center.

    The Bijnor Rebellion of 1857 was a revolt of the Muslim minority in the Bijnor district of India against the British East India Company and Hindu loyalists. Sir Sayyid Ahmad Khan was an Indian Muslim serving the British Company. His account of the events of 1857 is the only one produced by an Indian who both participated in and analyzed the…

  13. PANDANGAN RUMAH TANGGA SASARAN (RTS TERHADAP PELAKSANAAN DANA BERGULIR PNPM-MP DI KELURAHAN BALAI GADANG, KOTA PADANG

    Directory of Open Access Journals (Sweden)

    Elparianti Elparianti

    2017-01-01

    Full Text Available This article background is information about the data differences between statistically and realities in society about PNPM-MP Programe. Statistically PNPM-MP is considered good enough in the effort to reduce poverty have been able to reduce the number of target households in the Balai Gadang, but the reality in the field are still many poor people. In general view of the target households are not re-categorized as the objectives of the program provides pastures that show received a position as a party that can not accept a revolving fund, As for the efforts made by the PNPM-MP after the target households are not back to being targeted by inviting households to be targeted to training events associated with increased economic cooperation with the family and other financial institutions greater. As for the view of the target households on the implementation of the revolving fund PNPM-MP in the fight against poverty can be concluded that in general the target households provide a positive outlook for feel that the borrowing of funds on a rolling basis from PNPM-MP, especially for households sesaran the installment lending smoothly and has had previous attempts Artikel ini dilatarbelakangi oleh adanya perbedaan informasi antara data secara statistik dengan realitas yang ada dalam masyarakat. secara statistik pelaksanaan PNPM-MP dinilai cukup baik dalam upaya menanggulangi kemiskinan telah mampu menurunkan jumlah rumah tangga sasaran  (RTS di Kelurahan Balai Gadang, namun realitasnya dilapangan masih banyak masyarakat misikin. Secara umum pandangan rumah tangga sasaran (RTS tidak kembali terkategori sebagai sasaran pelaksanaan program yaitu RTS memberikan padangan yang menunjukkan menerima posisi sebagai pihak yang sudah tidak bisa menerima dana bergulir, adapun upaya yang dilakukan oleh pihak pelaksanaan PNPM-MP setelah RTS tidak kembali menjadi sasaran dengan mengundang RTS ke acara pelatihan yang berhubungan dengan peningkatan ekonomi keluarga

  14. Sir Ronald Ross and the Malarial Parasite

    Indian Academy of Sciences (India)

    1997-08-20

    Aug 20, 1997 ... In 1857, a General in the Indian Army, Sir C C G Ross and his wife Matilda .... generally low-caste Indians who required a fee before drinking the water and ... nary demand being made upon their systems, as by fatigue, chill,.

  15. Optimization of a GCaMP calcium indicator for neural activity imaging.

    Science.gov (United States)

    Akerboom, Jasper; Chen, Tsai-Wen; Wardill, Trevor J; Tian, Lin; Marvin, Jonathan S; Mutlu, Sevinç; Calderón, Nicole Carreras; Esposti, Federico; Borghuis, Bart G; Sun, Xiaonan Richard; Gordus, Andrew; Orger, Michael B; Portugues, Ruben; Engert, Florian; Macklin, John J; Filosa, Alessandro; Aggarwal, Aman; Kerr, Rex A; Takagi, Ryousuke; Kracun, Sebastian; Shigetomi, Eiji; Khakh, Baljit S; Baier, Herwig; Lagnado, Leon; Wang, Samuel S-H; Bargmann, Cornelia I; Kimmel, Bruce E; Jayaraman, Vivek; Svoboda, Karel; Kim, Douglas S; Schreiter, Eric R; Looger, Loren L

    2012-10-03

    Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Recent efforts in protein engineering have significantly increased the performance of GECIs. The state-of-the art single-wavelength GECI, GCaMP3, has been deployed in a number of model organisms and can reliably detect three or more action potentials in short bursts in several systems in vivo. Through protein structure determination, targeted mutagenesis, high-throughput screening, and a battery of in vitro assays, we have increased the dynamic range of GCaMP3 by severalfold, creating a family of "GCaMP5" sensors. We tested GCaMP5s in several systems: cultured neurons and astrocytes, mouse retina, and in vivo in Caenorhabditis chemosensory neurons, Drosophila larval neuromuscular junction and adult antennal lobe, zebrafish retina and tectum, and mouse visual cortex. Signal-to-noise ratio was improved by at least 2- to 3-fold. In the visual cortex, two GCaMP5 variants detected twice as many visual stimulus-responsive cells as GCaMP3. By combining in vivo imaging with electrophysiology we show that GCaMP5 fluorescence provides a more reliable measure of neuronal activity than its predecessor GCaMP3. GCaMP5 allows more sensitive detection of neural activity in vivo and may find widespread applications for cellular imaging in general.

  16. Survey of college students' MP3 listening: Habits, safety issues, attitudes, and education.

    Science.gov (United States)

    Hoover, Alicia; Krishnamurti, Sridhar

    2010-06-01

    To survey listening habits and attitudes of typical college students who use MP3 players and to investigate possible safety issues related to MP3 player listening. College students who were frequent MP3 player users (N = 428) filled out a 30-item online survey. Specific areas probed by the present survey included frequency and duration of MP3 player use, MP3 player volume levels used, types of earphones used, typical environments in which MP3 player was worn, specific activities related to safety while listening to MP3 players, and attitudes toward MP3 player use. The majority of listeners wore MP3 players for less than 2 hr daily at safe volume levels. About one third of respondents reported being distracted while wearing an MP3 player, and more than one third of listeners experienced soreness in their ears after a listening session. About one third of respondents reported occasionally using their MP3 players at maximum volume levels. Listeners indicated willingness to (a) reduce volume levels, (b) decrease listening duration, and (c) buy specialized earphones to conserve their hearing. The study found concerns regarding the occasional use of MP3 players at full volume and reduced environmental awareness among some college student users.

  17. Immunomodulation of Parkinson's disease using Mucuna pruriens (Mp).

    Science.gov (United States)

    Rai, Sachchida Nand; Birla, Hareram; Zahra, Walia; Singh, Saumitra Sen; Singh, Surya Pratap

    2017-11-01

    Immune control is associated with nigrostriatal neuroprotection for Parkinson's disease (PD); though its direct cause and effect relationships have not yet been realized and modulating the immune system for therapeutic gain has been openly discussed. While the pathobiology of PD remains in study, neuroinflammation is thought to speed nigrostriatal degeneration. The neuroinflammatory cascade associated with PD begins with aggregation of misfolded or post-translationally modified α-synuclein (α-syn). Such aggregation results in neuronal cell death and the presence of chronically activated glia (microglia and astroglia), leading to the production of proinflammatory cytokines like tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), IL-6, and enzymes such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and cyclooxygenase-2 (COX-2). These changes in the glial phenotype can affect the central nervous system (CNS) microenvironment by producing a pro-inflammatory milieu that speeds PD pathogenesis. Mucuna pruriens (Mp) is the most popular drug in Ayurveda, the Indian system of medicine. Several reports have suggested that it possesses analgesic, anti-inflammatory, anti-neoplastic, anti-epileptic and anti-microbial activities. Mp contain L-DOPA and ursolic acid which has an anti-inflammatory property. There are very few literatures which show the immunomodulatory activity of Mp in PD, several researchers have tried to work on the immunomodulatory activity of Mp in some other diseases. The results of several studies show that Mp modulate the immune components like TNF-α, IL-6, IFN-λ, IL-1β, iNOS and IL-2 in the CNS. It also modulates the activity of the transcription factor NF-kB which plays an important role in the progression of the PD. Thus, by altering these cytokines or transcription factors, Mp protects or prevents the progression of PD. Thus in this review we try to explore the immunomodulatory activity of Mp in PD. Copyright © 2017

  18. Permanence for a Delayed Nonautonomous SIR Epidemic Model with Density-Dependent Birth Rate

    Directory of Open Access Journals (Sweden)

    Li Yingke

    2011-01-01

    Full Text Available Based on some well-known SIR models, a revised nonautonomous SIR epidemic model with distributed delay and density-dependent birth rate was considered. Applying some classical analysis techniques for ordinary differential equations and the method proposed by Wang (2002, the threshold value for the permanence and extinction of the model was obtained.

  19. SIR-2 Data Normalization and Integration with M3 Data

    Science.gov (United States)

    Grumpe, A.; Felder, M. P.; Wöhler, C.; Mall, U.

    2013-09-01

    The point spectrometer SIR-2 on Chandrayaan-1 provided radiance spectra integrated over circular footprints of 200 m diameter in the wavelength range 934-2410.8 nm in 256 channels [1]. To analyze SIR-2 reflectance spectra in their spatial context, a coregistration to Chandrayaan-1 M³ hyperspectral images [2] as well as a correction for topography and thermal emission are inevitable. The thermal and topographic correction procedure is based on the surface temperature and a digital elevation model (DEM) inferred from M³ data. The corrected reflectance spectra are then normalized to a standard illumination and viewing geometry.

  20. Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression

    International Nuclear Information System (INIS)

    Chang, C.-J.; Hsu, C.-C.; Yung, M.-C.; Chen, K.-Y.; Tzao Ching; Wu, W.-F.; Chou, H.-Y.; Lee, Y.-Y.; Lu, K.-H.; Chiou, S.-H.; Ma, H.-I

    2009-01-01

    CD133-expressing glioma cells play a critical role in tumor recovery after treatment and are resistant to radiotherapy. Herein, we demonstrated that glioblastoma-derived CD133-positive cells (GBM-CD133 + ) are capable of self-renewal and express high levels of embryonic stem cell genes and SirT1 compared to GBM-CD133 - cells. To evaluate the role of SirT1 in GBM-CD133 + , we used a lentiviral vector expressing shRNA to knock-down SirT1 expression (sh-SirT1) in GBM-CD133 + . Silencing of SirT1 significantly enhanced the sensitivity of GBM-CD133 + to radiation and increased the level of radiation-mediated apoptosis. Importantly, knock-down of SirT1 increased the effectiveness of radiotherapy in the inhibition of tumor growth in nude mice transplanted with GBM-CD133 + . Kaplan-Meier survival analysis indicated that the mean survival rate of GBM-CD133 + mice treated with radiotherapy was significantly improved by Sh-SirT1 as well. In sum, these results suggest that SirT1 is a potential target for increasing the sensitivity of GBM and glioblastoma-associated cancer stem cells to radiotherapy.

  1. Serum inflammatory markers in the elderly: are they useful in differentiating sepsis from SIRS?

    Directory of Open Access Journals (Sweden)

    Mahshid Talebi-Taher

    2014-06-01

    Full Text Available Differentiating sepsis from other noninfectious causes of systemic inflammation is often difficult in the elderly. The aim of this study was to evaluate the ability of C-reactive protein (CRP, Erythrocyte Sedimentation Rate (ESR, procalcitonin (PCT, and Interleukin-6 (IL-6 to identify elderly patients with sepsis. In this single center prospective observational study, we included all consecutive elderly patients admitted with suspected sepsis and systemic inflammatory response syndrome (SIRS in an emergency department. Blood samples for measuring CRP, PCT, IL-6, ESR and white blood cells (WBC count were taken at first day of admission. Sensitivity, specificity, positive and negative predictive values were calculated for each inflammatory markers being studied. A total of 150 elderly patients aged 65 and older, 50 with sepsis and 50 with SIRS, and fifty individuals in a normal health status were included. CRP exhibited the greatest sensitivity (98% and negative predictive value (98.6% and performed best in differentiating patients with sepsis from those with SIRS. In a receiver operating characteristic curve analysis, IL-6 performed best in distinguishing between SIRS and the control group (AUC 0.75, 95% CI. On the other hand, both CRP and ESR appeared to be a more accurate diagnostic parameter for differentiating sepsis from SIRS among elderly patients.

  2. Sir William Jenner (1815-1898) and Queen Victoria.

    Science.gov (United States)

    Seddon, David; Queen Victoria

    2004-08-01

    This biographical note outlines the work of Sir William Jenner (1815-1898), court physician 1861-93 and President of the Royal College of Physicians 1881-8. He was the first to distinguish between typhoid and typhus both clinically and pathologically.

  3. dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner

    Directory of Open Access Journals (Sweden)

    Kushal Kr. Banerjee

    2012-12-01

    Full Text Available Sir2, an evolutionarily conserved NAD+-dependent deacetylase, has been implicated as a key factor in mediating organismal life span. However, recent contradictory findings have brought into question the role of Sir2 and its orthologs in regulating organismal longevity. In this study, we report that Drosophila Sir2 (dSir2 in the adult fat body regulates longevity in a diet-dependent manner. We used inducible Gal4 drivers to knock down and overexpress dSir2 in a tissue-specific manner. A diet-dependent life span phenotype of dSir2 perturbations (both knockdown and overexpression in the fat body, but not muscles, negates the effects of background genetic mutations. In addition to providing clarity to the field, our study contrasts the ability of dSir2 in two metabolic tissues to affect longevity. We also show that dSir2 knockdown abrogates fat-body dFOXO-dependent life span extension. This report highlights the importance of the interplay between genetic factors and dietary inputs in determining organismal life spans.

  4. Comparison of QSOFA score and SIRS criteria as screening mechanisms for emergency department sepsis.

    Science.gov (United States)

    Haydar, Samir; Spanier, Matthew; Weems, Patricia; Wood, Samantha; Strout, Tania

    2017-11-01

    The Quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA) score has been shown to accurately predict mortality in septic patients and is part of recently proposed diagnostic criteria for sepsis. We sought to ascertain the sensitive of the score in diagnosing sepsis, as well as the diagnostic timeliness of the score when compared to traditional systemic inflammatory response syndrome (SIRS) criteria in a population of emergency department (ED) patients treated in the ED, admitted, and subsequently discharged with a diagnosis of sepsis. Electronic health records of 200 patients who were treated for suspected sepsis in our ED and ultimately discharged from our hospital with a diagnosis of sepsis were randomly selected for review from a population of adult ED patients (N=1880). Data extracted included the presence of SIRS criteria and the qSOFA score as well as time required to meet said criteria. In this cohort, 94.5% met SIRS criteria while in the ED whereas only 58.3% met qSOFA. The mean time from arrival to SIRS documentation was 47.1min (95% CI: 36.5-57.8) compared to 84.0min (95% CI: 62.2-105.8) for qSOFA. The median ED "door" to positive SIRS criteria was 12min and 29min for qSOFA. Although qSOFA may be valuable in predicting sepsis-related mortality, it performed poorly as a screening tool for identifying sepsis in the ED. As the time to meet qSOFA criteria was significantly longer than for SIRS, relying on qSOFA alone may delay initiation of evidence-based interventions known to improve sepsis-related outcomes. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Delineation of major geologic structures in Turkey using SIR-B data

    Science.gov (United States)

    Toksoz, M. N.; Pettengill, G. H.; Ford, P.; Gulen, L.

    1984-01-01

    Shuttle Imaging Radar-B (SIR-B) images of well mapped segments of major faults, such as the North Anatolian Fault (NAF) and East Anatolian Fault (EAF) will be studied to identify the prominent signatures that characterize the fault zones for those specific regions. The information will be used to delineate the unmapped fault zones in areas with similar geological and geomorphological properties. The data obtained from SIR-B images will be compared and correlated with the LANDSAT thematic mapper and seismicity alignments based on well constrained earthquake epicenters.

  6. Generation new MP3 data set after compression

    Science.gov (United States)

    Atoum, Mohammed Salem; Almahameed, Mohammad

    2016-02-01

    The success of audio steganography techniques is to ensure imperceptibility of the embedded secret message in stego file and withstand any form of intentional or un-intentional degradation of secret message (robustness). Crucial to that using digital audio file such as MP3 file, which comes in different compression rate, however research studies have shown that performing steganography in MP3 format after compression is the most suitable one. Unfortunately until now the researchers can not test and implement their algorithm because no standard data set in MP3 file after compression is generated. So this paper focuses to generate standard data set with different compression ratio and different Genre to help researchers to implement their algorithms.

  7. Adhesive-Bonded Tab Attaches Thermocouples to Titanium

    Science.gov (United States)

    Cook, C. F.

    1982-01-01

    Mechanical strength of titanium-alloy structures that support thermocouples is preserved by first spotwelding thermocouples to titanium tabs and then attaching tabs to titanium with a thermosetting adhesive. In contrast to spot welding, a technique previously used for thermocouples, fatigue strength of the titanium is unaffected by adhesive bonding. Technique is also gentler than soldering or attaching thermocouples with a tap screw.

  8. Analysis of the MPEG-1 Layer III (MP3) Algorithm using MATLAB

    CERN Document Server

    Thiagarajan, Jayaraman

    2011-01-01

    The MPEG-1 Layer III (MP3) algorithm is one of the most successful audio formats for consumer audio storage and for transfer and playback of music on digital audio players. The MP3 compression standard along with the AAC (Advanced Audio Coding) algorithm are associated with the most successful music players of the last decade. This book describes the fundamentals and the MATLAB implementation details of the MP3 algorithm. Several of the tedious processes in MP3 are supported by demonstrations using MATLAB software. The book presents the theoretical concepts and algorithms used in the MP3 stand

  9. SirT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells

    International Nuclear Information System (INIS)

    Xie Yuexia; Zhang Jianghong; Shao Chunlin; Xu Yanwu

    2012-01-01

    Intratumoral hypoxia is an important contributory factor to tumor cell resistance to radiotherapy. SirT1, a nicotinamide adenine dinucleotide (NAD + )-dependent histone/protein deacetylase, has been linked to the decrease of radiation-induced DNA damage and seems to be critical for cancer therapy. The purpose of this study was to investigate the role of SirT1 in hypoxia-induced radiation response on hepatoma cells. It was found that the administration with resveratrol, a putative SirT1 activator, enhanced the resistance of HepG2 cells against radiation-induced DNA damage of MN formation under hypoxia condition; while nicotinamide, a well-known SirT1 inhibitor, sensitized this radiation damage. Nevertheless, pretreatment of cells with 10058-F4, a specific inhibitor of c-Myc, almost eliminated the nicotinamide-induced radiosensitive effect. Further studies revealed that resveratrol inhibited c-Myc protein accumulation via up-regulation of SirT1 expression and deacetylase activity, and this loss of c-Myc protein was abolished by inhibiting its degradation in the presence of MG132, a potent inhibitor of proteasome. In contrast, nicotinamide attenuated c-Myc protein degradation induced by radiation under hypoxia through inhibition of SirT1 deacetylase activity. Our findings suggest that SirT1 could serve as a novel potent target of radiation-induced DNA damage and thus as a potential strategy to advance the efficiency of radiation therapy in hepatoma entities. (author)

  10. Overlapping Communication and Computation with OpenMP and MPI

    Directory of Open Access Journals (Sweden)

    Timothy H. Kaiser

    2001-01-01

    Full Text Available Machines comprised of a distributed collection of shared memory or SMP nodes are becoming common for parallel computing. OpenMP can be combined with MPI on many such machines. Motivations for combing OpenMP and MPI are discussed. While OpenMP is typically used for exploiting loop-level parallelism it can also be used to enable coarse grain parallelism, potentially leading to less overhead. We show how coarse grain OpenMP parallelism can also be used to facilitate overlapping MPI communication and computation for stencil-based grid programs such as a program performing Gauss-Seidel iteration with red-black ordering. Spatial subdivision or domain decomposition is used to assign a portion of the grid to each thread. One thread is assigned a null calculation region so it was free to perform communication. Example calculations were run on an IBM SP using both the Kuck & Associates and IBM compilers.

  11. The susceptible-infected-recovered (SIR) model for viral marketing

    Science.gov (United States)

    Ismail, Siti Suhaila; Akil, Ku Azlina Ku; Chulan, Majdah; Sharif, Noorzila

    2017-11-01

    Viral marketing is a marketing strategy utilizes social media to spread information about a product or services provided. It is the most powerful way to share information in a short amount of time. The objective of this study is to investigate the dynamic of viral marketing within a time duration in the point of view of mathematics. This study used the epidemiological model known as Susceptible-Infected-Recovered (SIR). The model consists of a system of three differential equations with three state variables namely susceptible (S), infected (I) and recovered (R). It considers a case of SIR model with demography. Numerical experiments have been performed. The results show that viral marketing reaches its peak within two days. The online messages shared will become higher if the initial number of the infected individual has been increased.

  12. MR imaging in epilepsy with use of 3D MP-RAGE

    International Nuclear Information System (INIS)

    Tanaka, Akio; Ohno, Sigeru; Sei, Tetsuro; Kanazawa, Susumu; Yasui, Koutaro; Kuroda, Masahiro; Hiraki, Yoshio; Oka, Eiji

    1996-01-01

    The patients were 40 males and 33 females; their ages ranged from 1 month to 39 years (mean: 15.7 years). The patients underwent MR imaging, including spin-echo T 1 -weighted, turbo spin-echo proton density/T 2 -weighted, and 3D magnetization-prepared rapid gradient-echo (3D MP-RAGE) images. These examinations disclosed 39 focal abnormalities. On visual evaluation, the boundary of abnormal gray matter in the neuronal migration disorder (NMD) cases was most clealy shown on 3D MP-RAGE images as compared to the other images. This is considered to be due to the higher spatial resolution and the better contrast of the 3D MP-RAGE images than those of the other techniques. The relative contrast difference between abnormal gray matter and the adjacent white matter was also assessed. The results revealed that the contrast differences on the 3D MP-RAGE images were larger than those on the other images; this was statistically significant. Although the sensitivity of 3D MP-RAGE for NMD was not specifically evaluated in this study, the possibility of this disorder, in cases suspected on other images, could be ruled out. Thus, it appears that the specificity with respect to NMD was at least increased with us of 3D MP-RAGE. 3D MP-RAGE also enabled us to build three-dimensional surface models that were helpful in understanding the three-dimensional anatomy. Furthermore. 3D MP-RAGE was considered to be the best technique for evaluating hippocampus atrophy in patients with MTS. On the other hand, the sensitivity in the signal change of the hippocampus was higher on T 2 -weighted images. In addition, demonstration of cortical tubers of tuberous sclerosis in neurocutaneous syndrome was superior on T 2 -weighted images than on 3D MP-RAGE images. (K.H.)

  13. Sir Karl Popper and his philosophy of physics

    Science.gov (United States)

    Jammer, Max

    1991-12-01

    The eminent mathematical physicist Sir Hermann Bondi once said: “There is no more to science than its method, and there is no more to its method than Popper has said.” Indeed, many regard Sir Karl Raimund Popper the greatest philosopher of science in our generation. Much of what Popper “has said” refers to physics, but physicists, generally speaking, have little knowledge of what he has said. True, Popper's philosophy of science and, in particular, his realistic interpretation of quantum mechanics deviates considerably from the generally accepted doctrine. But as Popper, rightly I think, points out, it is precisely the proliferation of divergent theories which promotes the growth of scientific knowledge; it would be a danger for physics if physicists were dogmatically tied to a single theory or would not test their theory against alternatives. It is for this purpose that, on the occasion of the nonagenarian celebration of Popper's birthday, the present essay has been written.

  14. The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

    Science.gov (United States)

    The establishment of the epigenetic mark H4K20me1 (monomethylation of H4K20) by PR-Set7 during G2/M directly impacts S-phase progression and genome stability. However, the mechanisms involved in the regulation of this event are not well understood. Here we show that SirT2 regulates H4K20me1 depositi...

  15. Verification of the linearity of the new SIR using sources of 64Cu and 99mTc

    International Nuclear Information System (INIS)

    Michotte, Carine

    2012-02-01

    The linearity of the new SIR electronics has been verified by looking for deviations from the exponential decay for several 64 Cu and 99m Tc sources. Data analyses are compared with the half-life used as a fixed or free parameter. It is concluded that no significant non-linearity is observed in the new SIR. For comparison, the same method has been applied to analyse existing data from the original SIR. (author)

  16. Sir Robert Sidney’s Poems Revisited: the alternative sequence

    OpenAIRE

    Relvas, Maria de Jesus C.

    1997-01-01

    The essay approaches the lyric sequence written by Sir Robert Sidney (1563-1626) in the Elizabethan age, by mainly exploring its unique formal structure, which encloses an alternative sequence formed by a re-numbering of several poems.

  17. Finite micro-tab system for load control on a wind turbine

    International Nuclear Information System (INIS)

    Bach, A B; Lennie, M; Nayeri, C N; Paschereit, C O; Pechlivanoglou, G

    2014-01-01

    Finite micro-tabs have been investigated experimentally to evaluate the potential for load control on wind turbines. Two dimensional full span, as well as multiple finite tabs of various aspect ratios have been studied on an AH93W174 airfoil at different chord wise positions. A force balance was used to measure the aerodynamic loads. Furthermore, the wake vortex system consisting of the Karman vortex street as well as the tab tip vortices was analyzed with a 12-hole probe and hot wire anemometry. Finally, conventional oil paint as well as a quantitative digital flow analysis technique called SMARTviz were used to visualize the flow around the finite tab configurations. Results have shown that the devices are an effective solution to alleviate the airfoils overall load. The influence of the tab height, tab position as well as the finite tab aspect ratio on the lift and lift to drag ratio have been evaluated. It could be shown, that the lift difference can either be varied by changing the tab height as well as by altering the aspect ratio of the finite tabs. The drag of a two-dimensional flap is directly associated with the vortex street, while in the case of the finite tab, the solidity ratio of the tabs has the strongest effect on the drag. Therefore, the application of a finite tab system showed to improve the lift to drag ratio

  18. SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation

    International Nuclear Information System (INIS)

    Xie, Yuexia; Tu, Wenzhi; Zhang, Jianghong; He, Mingyuan; Ye, Shuang; Dong, Chen; Shao, Chunlin

    2015-01-01

    Highlights: • γ-Irradiation induced bystander effects between hepatoma cells and hepatocyte cells. • SirT1 played a protective role in regulating this bystander effect. • SirT1 contributed to the protective effects via elimination the accumulation of ROS. • The activity of c-Myc is critical for maintaining the protective role of SirT1. - Abstract: Radiation-induced bystander effect (RIBE) has important implications for secondary cancer risk assessment during cancer radiotherapy, but the bystander signaling processes, especially under hypoxic condition, are still largely unclear. The present study found that micronuclei (MN) formation could be induced in the non-irradiated HL-7702 hepatocyte cells after being treated with the conditioned medium from irradiated hepatoma HepG2 and SK-Hep-1 cells under either normoxia or hypoxia. This bystander response was dramatically diminished or enhanced when the SirT1 gene of irradiated hepatoma cells was overexpressed or knocked down, respectively, especially under hypoxia. Meanwhile, SirT1 knockdown promoted transcriptional activity for c-Myc and facilitated ROS accumulation. But both of the increased bystander responses and ROS generation due to SirT1-knockdown were almost completely suppressed by c-Myc interference. Moreover, ROS scavenger effectively abolished the RIBE triggered by irradiated hepatoma cells even with SirT1 depletion. These findings provide new insights that SirT1 has a profound role in regulating RIBE where a c-Myc-dependent release of ROS may be involved

  19. SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation

    Energy Technology Data Exchange (ETDEWEB)

    Xie, Yuexia [Institute of Radiation Medicine, Fudan University, Shanghai (China); Central Laboratory, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai (China); Tu, Wenzhi; Zhang, Jianghong; He, Mingyuan; Ye, Shuang; Dong, Chen [Institute of Radiation Medicine, Fudan University, Shanghai (China); Shao, Chunlin, E-mail: clshao@shmu.edu.cn [Institute of Radiation Medicine, Fudan University, Shanghai (China)

    2015-02-15

    Highlights: • γ-Irradiation induced bystander effects between hepatoma cells and hepatocyte cells. • SirT1 played a protective role in regulating this bystander effect. • SirT1 contributed to the protective effects via elimination the accumulation of ROS. • The activity of c-Myc is critical for maintaining the protective role of SirT1. - Abstract: Radiation-induced bystander effect (RIBE) has important implications for secondary cancer risk assessment during cancer radiotherapy, but the bystander signaling processes, especially under hypoxic condition, are still largely unclear. The present study found that micronuclei (MN) formation could be induced in the non-irradiated HL-7702 hepatocyte cells after being treated with the conditioned medium from irradiated hepatoma HepG2 and SK-Hep-1 cells under either normoxia or hypoxia. This bystander response was dramatically diminished or enhanced when the SirT1 gene of irradiated hepatoma cells was overexpressed or knocked down, respectively, especially under hypoxia. Meanwhile, SirT1 knockdown promoted transcriptional activity for c-Myc and facilitated ROS accumulation. But both of the increased bystander responses and ROS generation due to SirT1-knockdown were almost completely suppressed by c-Myc interference. Moreover, ROS scavenger effectively abolished the RIBE triggered by irradiated hepatoma cells even with SirT1 depletion. These findings provide new insights that SirT1 has a profound role in regulating RIBE where a c-Myc-dependent release of ROS may be involved.

  20. MP3 audio-editing software for the department of radiology

    International Nuclear Information System (INIS)

    Hong Qingfen; Sun Canhui; Li Ziping; Meng Quanfei; Jiang Li

    2006-01-01

    Objective: To evaluate the MP3 audio-editing software in the daily work in the department of radiology. Methods: The audio content of daily consultation seminar, held in the department of radiology every morning, was recorded and converted into MP3 audio format by a computer integrated recording device. The audio data were edited, archived, and eventually saved in the computer memory storage media, which was experimentally replayed and applied in the research or teaching. Results: MP3 audio-editing was a simple process and convenient for saving and searching the data. The record could be easily replayed. Conclusion: MP3 audio-editing perfectly records and saves the contents of consultation seminar, and has replaced the conventional hand writing notes. It is a valuable tool in both research and teaching in the department. (authors)

  1. SIR JOHN CRAWFORD MEMORIAL ADDRESS: Agriculture: The challenges of the 21st century

    OpenAIRE

    Beddington, Sir John

    2012-01-01

    The Sir John Crawford Memorial Address has been presented since 1985, in honour of the distinguished Australian civil servant, educator and agriculturalist in whose name the Crawford Fund was established. Sir John Crawford was a remarkable Australian who contributed at the highest levels, and was a passionate supporter of international agricultural research for development. This talk draws attention to four current and interrelated trends that suggest the world will be rather different by 202...

  2. Embrittlement phenomenon of Ag core MP35N cable as lead conductor in medical device.

    Science.gov (United States)

    Wang, Ling; Li, Bernie; Zhang, Haitao

    2013-02-01

    Ag core MP35N (Ag/MP35N) wire has been used in lead electric conductor wires in the medical device industry for many years. Recently it was noticed that the combination of silver and MP35N restricts its wire drawing process. The annealing temperature in Ag/MP35N has to be lower than the melting temperature of pure Ag (960 °C), which cannot fully anneal MP35N. The lower annealing temperature results in a highly cold worked MP35N, which significantly reduces Ag/MP35N ductility. The embrittlement phenomenon of Ag/MP35N cable was observed in tension and bending deformation. The effect of the embrittlement on the wire flex fatigue life was evaluated using a newly developed flex fatigue testing method. The Ag/MP35N cable fatigue results was analyzed with a Coffin-Manson approach and compared to the MP35N cable fatigue results. The root causes of the Ag/Mp35N embrittlement phenomenon are discussed. Copyright © 2012 Elsevier Ltd. All rights reserved.

  3. Facilitation of the USHPRR Program MP-1 Shipments

    Energy Technology Data Exchange (ETDEWEB)

    Woolstenhulme, Eric C. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-04-11

    This report describes the activities necessary to support the numerous transportation tasks involved with the successful completion of the mini-plate MP-1 and future MP experiments for the U.S. High Performance Research Reactor HEU to LEU conversion program. It includes information about the general activities necessary to implement equipment, operational processes, and safety basis changes required at the shipping facility and receipt facilities to support the shipments.

  4. Facilitation of the USHPRR Program MP-1 Shipments

    International Nuclear Information System (INIS)

    Woolstenhulme, Eric C.

    2017-01-01

    This report describes the activities necessary to support the numerous transportation tasks involved with the successful completion of the mini-plate MP-1 and future MP experiments for the U.S. High Performance Research Reactor HEU to LEU conversion program. It includes information about the general activities necessary to implement equipment, operational processes, and safety basis changes required at the shipping facility and receipt facilities to support the shipments.

  5. Concurrent object-oriented programming: The MP-Eiffel approach

    OpenAIRE

    Silva, Miguel Augusto Mendes Oliveira e

    2004-01-01

    This article evaluates several possible approaches for integrating concurrency into object-oriented programming languages, presenting afterwards, a new language named MP-Eiffel. MP-Eiffel was designed attempting to include all the essential properties of both concurrent and object-oriented programming with simplicity and safety. A special care was taken to achieve the orthogonality of all the language mechanisms, allowing their joint use without unsafe side-effects (such as inh...

  6. Identification of Candida Species Using MP65 Gene and Evaluation of the Candida albicans MP65 Gene Expression in BALB/C Mice.

    Science.gov (United States)

    Bineshian, Farahnaz; Yadegari, Mohammad Hossien; Sharifi, Zohre; Akbari Eidgahi, Mohammadreza; Nasr, Reza

    2015-05-01

    Systemic candidiasis is a major public health concern. In particular, in immunocompromised people, such as patients with neutropenia, patients with Acquired Immune Deficiency Syndrome (AIDS) and cancer who are undergoing antiballistic chemotherapy or bone marrow transplants, and people with diabetes. Since the clinical signs and symptoms are nonspecific, early diagnosis is often difficult. The 65-kDa mannoprotein (MP65) gene of Candida albicans is appropriate for detection and identification of systemic candidiasis. This gene encodes a putative b-glucanase mannoprotein of 65 kDa, which plays a major role in the host-fungus relationship, morphogenesis and pathogenicity. The current study aimed to identify different species of Candida (C. albicans, C. glabrata and C. parapsilosis) using the Polymerase Chain Reaction (PCR) technique and also to evaluate C. albicans MP65 gene expression in BALB/C mice. All yeast isolates were identified on cornmeal agar supplemented with tween-80, germ tube formation in serum, and assimilation of carbon sources in the API 20 C AUX yeast identification system. Polymerase Chain Reaction was performed on all samples using species-specific primers for the MP65 65 kDa gene. After RNA extraction, cDNA synthesis was performed by the Maxime RT Pre Mix kit. Candida albicans MP65 gene expression was evaluated by quantitative Real-Time (q Real-Time) and Real-Time (RT) PCR techniques. The 2-ΔΔCT method was used to analyze relative changes in gene expression of MP65. For statistical analysis, nonparametric Wilcoxon test was applied using the SPSS version 16 software. Using biochemical methods, one hundred, six and one isolates of clinical samples were determined as C. albicans, C. glabrata and C. parapsilosis, respectively. Species-specific primers for PCR experiments were applied to clinical specimens, and in all cases a single expected band for C. albicans, C. glabrata and C. parapsilosis was obtained (475, 361 and 124 base pairs, respectively

  7. Stability analysis of the Euler discretization for SIR epidemic model

    International Nuclear Information System (INIS)

    Suryanto, Agus

    2014-01-01

    In this paper we consider a discrete SIR epidemic model obtained by the Euler method. For that discrete model, existence of disease free equilibrium and endemic equilibrium is established. Sufficient conditions on the local asymptotical stability of both disease free equilibrium and endemic equilibrium are also derived. It is found that the local asymptotical stability of the existing equilibrium is achieved only for a small time step size h. If h is further increased and passes the critical value, then both equilibriums will lose their stability. Our numerical simulations show that a complex dynamical behavior such as bifurcation or chaos phenomenon will appear for relatively large h. Both analytical and numerical results show that the discrete SIR model has a richer dynamical behavior than its continuous counterpart

  8. L’économie politique du désir dans le rituel et le militantisme au SriLanka

    Directory of Open Access Journals (Sweden)

    Wim Van Daele

    2013-03-01

    Full Text Available Le désir est au cœur des interactions complexes entre le développement et la religion. Cet article examine ses différentes expressions, comme étant une des préoccupations fondamentales de nombreuses religions, qui motivent à la fois le développement et les alternatives au développement. Au SriLanka, face au changement social, la forme néolibérale et mondialisée du développement est comprise et réinterprétée à travers des idiomes et des formations locales du désir. L’économie néolibérale cultive le désir et mène à un accroissement présumé de la présence des preta (fantômes affamés et avides qui se manifestent parfois au moment de la mort d’une personne. Les fantômes affamés, en tant que formations fétichisées du désir, trouvent un écho chez les consommateurs et les entrepreneurs, qui montrent unappétit insatiable vis-à-vis d’une richesse matérielle en constante croissance. Ainsi, l’apaisement ritualisé des fantômes affamés et le militantisme social de groupes tels que le Movement for National Land and Agricultural Reform (MONLAR sont clairement liés par leur préoccupation mutuelle face à l’insécurité existentielle des êtres humains et non humains, causée par un désir excessif et déséquilibré. L’action rituelle et le militantisme social divergent toutefois dans la formulation explicite de leurs préoccupations spécifiques concernant le désir. Le rituel matérialise et condense l’angoisse liée au désir, alors que le militantisme social décrit la fétichisation du désir en termes économiques, politiques et scientifiques plus abstraits.

  9. A Transparent Runtime Data Distribution Engine for OpenMP

    Directory of Open Access Journals (Sweden)

    Dimitrios S. Nikolopoulos

    2000-01-01

    Full Text Available This paper makes two important contributions. First, the paper investigates the performance implications of data placement in OpenMP programs running on modern NUMA multiprocessors. Data locality and minimization of the rate of remote memory accesses are critical for sustaining high performance on these systems. We show that due to the low remote-to-local memory access latency ratio of contemporary NUMA architectures, reasonably balanced page placement schemes, such as round-robin or random distribution, incur modest performance losses. Second, the paper presents a transparent, user-level page migration engine with an ability to gain back any performance loss that stems from suboptimal placement of pages in iterative OpenMP programs. The main body of the paper describes how our OpenMP runtime environment uses page migration for implementing implicit data distribution and redistribution schemes without programmer intervention. Our experimental results verify the effectiveness of the proposed framework and provide a proof of concept that it is not necessary to introduce data distribution directives in OpenMP and warrant the simplicity or the portability of the programming model.

  10. MP3 compression of Doppler ultrasound signals.

    Science.gov (United States)

    Poepping, Tamie L; Gill, Jeremy; Fenster, Aaron; Holdsworth, David W

    2003-01-01

    The effect of lossy, MP3 compression on spectral parameters derived from Doppler ultrasound (US) signals was investigated. Compression was tested on signals acquired from two sources: 1. phase quadrature and 2. stereo audio directional output. A total of 11, 10-s acquisitions of Doppler US signal were collected from each source at three sites in a flow phantom. Doppler signals were digitized at 44.1 kHz and compressed using four grades of MP3 compression (in kilobits per second, kbps; compression ratios in brackets): 1400 kbps (uncompressed), 128 kbps (11:1), 64 kbps (22:1) and 32 kbps (44:1). Doppler spectra were characterized by peak velocity, mean velocity, spectral width, integrated power and ratio of spectral power between negative and positive velocities. The results suggest that MP3 compression on digital Doppler US signals is feasible at 128 kbps, with a resulting 11:1 compression ratio, without compromising clinically relevant information. Higher compression ratios led to significant differences for both signal sources when compared with the uncompressed signals. Copyright 2003 World Federation for Ultrasound in Medicine & Biology

  11. Salmonella Dublin kan give store tab

    DEFF Research Database (Denmark)

    Nielsen, Torben Dahl; Nielsen, Liza Rosenbaum; Kudahl, Anne Margrethe Braad

    2012-01-01

    Store besætninger lider størst økonomisk tab ved infektion med Salmonella Dublin. Selv i en veldrevet besætning kan tabet løbe op i mellem 1,3 og 3,3 millioner kr. over en tiårs periode. Ved uhensigtsmæssige hygiejne- og managementrutiner kan tabet nemt blive meget højere.......Store besætninger lider størst økonomisk tab ved infektion med Salmonella Dublin. Selv i en veldrevet besætning kan tabet løbe op i mellem 1,3 og 3,3 millioner kr. over en tiårs periode. Ved uhensigtsmæssige hygiejne- og managementrutiner kan tabet nemt blive meget højere....

  12. Adolescents risky MP3-player listening and its psychosocial correlates

    NARCIS (Netherlands)

    Vogel, I.; Brug, J.; Ploeg, C.P.B. van der; Raat, H.

    2011-01-01

    Analogue to occupational noise-induced hearing loss, MP3-induced hearing loss may be evolving into a significant social and public health problem. To inform prevention strategies and interventions, this study investigated correlates of adolescents' risky MP3-player listening behavior primarily

  13. Scaled MP3 non-covalent interaction energies agree closely with accurate CCSD(T) benchmark data.

    Science.gov (United States)

    Pitonák, Michal; Neogrády, Pavel; Cerný, Jirí; Grimme, Stefan; Hobza, Pavel

    2009-01-12

    Scaled MP3 interaction energies calculated as a sum of MP2/CBS (complete basis set limit) interaction energies and scaled third-order energy contributions obtained in small or medium size basis sets agree very closely with the estimated CCSD(T)/CBS interaction energies for the 22 H-bonded, dispersion-controlled and mixed non-covalent complexes from the S22 data set. Performance of this so-called MP2.5 (third-order scaling factor of 0.5) method has also been tested for 33 nucleic acid base pairs and two stacked conformers of porphine dimer. In all the test cases, performance of the MP2.5 method was shown to be superior to the scaled spin-component MP2 based methods, e.g. SCS-MP2, SCSN-MP2 and SCS(MI)-MP2. In particular, a very balanced treatment of hydrogen-bonded compared to stacked complexes is achieved with MP2.5. The main advantage of the approach is that it employs only a single empirical parameter and is thus biased by two rigorously defined, asymptotically correct ab-initio methods, MP2 and MP3. The method is proposed as an accurate but computationally feasible alternative to CCSD(T) for the computation of the properties of various kinds of non-covalently bound systems.

  14. Hoarding symptoms among psychiatric outpatients: confirmatory factor analysis and psychometric properties of the Saving Inventory – Revised (SI-R

    Directory of Open Access Journals (Sweden)

    Siau Pheng Lee

    2016-10-01

    Full Text Available Abstract Background The growing interest in problematic hoarding as an independent clinical condition has led to the development of the Saving Inventory-Revised (SI-R to assess hoarding phenomenology. The SI-R is one of the most widely used instruments to measure hoarding symptoms; however, it lacks validation in non-Western samples. Methods The current study examined the construct, convergent, and discriminant validity of the SI-R among 500 outpatients at a psychiatric hospital in Singapore. The three-factor structure solution of the SI-R was fitted in a confirmatory factor analysis. Results The final model achieved mediocre fit (χ2 = 1026.02, df = 186; RMSEA = 0.095, SRMR = 0.06; CFI = 0.86; NNFI = 0.85. Two reverse-coded items (items 2 and 4 were removed due to insufficient factor loadings, resulting in the modified 21-item SI-R (SIR-21. Our findings indicate the need to further examine the construct validity of the SI-R, particularly in non-Western samples. Nonetheless, correlations with other hoarding-related constructs, such as anxiety (Beck Anxiety Inventory and depression (Beck Depression Inventory-II, supported the convergent and discriminant validity of the SIR-21 in our sample. Conclusions Findings in our current majority Chinese sample were consistent with previous observations from other Chinese samples. Implications were discussed from a cross-cultural perspective, such as cultural emphasis on saving for future use and overlap between the concepts of discarding and acquiring in Chinese samples. Future studies should also examine differences among other ethnic groups (e.g., Malay, Indian.

  15. LHCb: The search for $D^0\\rightarrow e^\\pm \\mu^\\mp$

    CERN Multimedia

    Bird, T

    2013-01-01

    In 2011 and 2012 LHCb collected a total of $3\\,\\mathrm{fb}^{-1}$ of $pp$-collisions, making LHCb the perfect place to look for rare charm decays. The lepton flavour violating decay $D^0\\rightarrow{}e^\\pm\\mu^\\mp$ is forbidden in the Standard Model and so it's detection would be a clear sign of new physics. In this poster an overview of the method used measure $\\mathcal{B}\\left(D^0\\rightarrow{}e^\\pm\\mu^\\mp\\right)$ with respect to $\\mathcal{B}\\left(D^0\\rightarrow{}\\pi^\\pm\\pi^\\mp\\right)$ is presented. It is estimated that this analysis will be able to set a limit on $\\mathcal{B}\\left(D^0\\rightarrow{}e^\\pm\\mu^\\mp\\right) < 10^{-8}$ at a $90\\%$ confidence level.

  16. On the applicability of MP2.5 method in atmospheric reactivity

    International Nuclear Information System (INIS)

    Suleiman, S.; Novotny, M.; Cernusak, I.

    2017-01-01

    Quantum chemical study has been performed on the reaction energies of the reactions of methyl iodide CH_3I and di-iodomethane CH_2I_2 with hydroxide radical. Both series of reactions were treated using the following methods: MP2, MP3, CCSD, CCSD(T) and also with the so-called MP2.5 approximation which is expected to be a good approximation to CCSD(T) within either chemical (±4 kJ/mol) or sub-chemical accuracy (±10 kJ/mol). We have used the correlation consistent cc-pvtz basis set in all calculations. In these atmospheric reactions, we considered various types of products. These reactions represent either isogyric processes or processes leading to atomic species. When comparing the MP2.5 and CCSD(T) data for reaction energies, our results indicate that there are some differences in reaction energies when the reaction contains different number of radicals and/or atoms on both sides. In addition, all the reactions including IO species do not fit into the 'MP2.5 computational philosophy'. (authors)

  17. Fkh1 and Fkh2 associate with Sir2 to control CLB2 transcription under normal and oxidative stress conditions

    Directory of Open Access Journals (Sweden)

    Christian eLinke

    2013-07-01

    Full Text Available The Forkhead box family of transcription factors is evolutionary conserved from yeast to higher eukaryotes and its members are involved in many physiological processes including metabolism, DNA repair, cell cycle, stress resistance, apoptosis and aging. In budding yeast, four Forkhead transcription factors were identified, namely Fkh1, Fkh2, Fhl1, and Hcm1, which are implicated in chromatin silencing, cell cycle regulation and stress response. These factors impinge transcriptional regulation during cell cycle progression, and histone deacetylases play an essential role in this process, e.g. the nuclear localisation of Hcm1 depends on Sir2 activity, whereas Sin3/Rpd3 silence cell cycle specific gene transcription in G2/M phase. However, a direct involvement of Sir2 in Fkh1/Fkh2-dependent regulation of target genes is at present unknown. Here, we show that Fkh1 and Fkh2 associate with Sir2 in G1 and M phase, and that Fkh1/Fkh2-mediated activation of reporter genes is antagonized by Sir2. We further report that Sir2 overexpression strongly affects cell growth in an Fkh1/Fkh2-dependent manner. In addition, Sir2 regulates the expression of the mitotic cyclin Clb2 through Fkh1/Fkh2-mediated binding to the CLB2 promoter in G1 and M phase. We finally demonstrate that Sir2 is also enriched at the CLB2 promoter under stress conditions, and that the nuclear localization of Sir2 is dependent on Fkh1 and Fkh2. Taken together, our results show a functional interplay between Fkh1/Fkh2 and Sir2 suggesting a novel mechanism of cell cycle repression. Thus, in budding yeast, not only the regulation of G2/M gene expression but also the protective response against stress could be directly coordinated by Fkh1 and Fkh2.

  18. VizieR Online Data Catalog: ChaMP X-ray point source catalog (Kim+, 2007)

    Science.gov (United States)

    Kim, M.; Kim, D.-W.; Wilkes, B. J.; Green, P. J.; Kim, E.; Anderson, C. S.; Barkhouse, W. A.; Evans, N. R.; Ivezic, Z.; Karovska, M.; Kashyap, V. L.; Lee, M. G.; Maksym, P.; Mossman, A. E.; Silverman, J. D.; Tananbaum, H. D.

    2009-01-01

    We present the Chandra Multiwavelength Project (ChaMP) X-ray point source catalog with ~6800 X-ray sources detected in 149 Chandra observations covering ~10deg2. The full ChaMP catalog sample is 7 times larger than the initial published ChaMP catalog. The exposure time of the fields in our sample ranges from 0.9 to 124ks, corresponding to a deepest X-ray flux limit of f0.5-8.0=9x10-16ergs/cm2/s. The ChaMP X-ray data have been uniformly reduced and analyzed with ChaMP-specific pipelines and then carefully validated by visual inspection. The ChaMP catalog includes X-ray photometric data in eight different energy bands as well as X-ray spectral hardness ratios and colors. To best utilize the ChaMP catalog, we also present the source reliability, detection probability, and positional uncertainty. (10 data files).

  19. Short-term auditory effects of listening to an MP3 player.

    Science.gov (United States)

    Keppler, Hannah; Dhooge, Ingeborg; Maes, Leen; D'haenens, Wendy; Bockstael, Annelies; Philips, Birgit; Swinnen, Freya; Vinck, Bart

    2010-06-01

    To determine the output levels of a commercially available MPEG layer-3 (MP3) player and to evaluate changes in hearing after 1 hour of listening to the MP3 player. First, A-weighted sound pressure levels (measured in decibels [dBA]) for 1 hour of pop-rock music on an MP3 player were measured on a head and torso simulator. Second, after participants listened to 1 hour of pop-rock music using an MP3 player, changes in hearing were evaluated with pure-tone audiometry, transient-evoked otoacoustic emissions, and distortion product otoacoustic emissions. Twenty-one participants were exposed to pop-rock music in 6 different sessions using 2 types of headphones at multiple preset gain settings of the MP3 player. Output levels of an MP3 player and temporary threshold and emission shifts after 1 hour of listening. The output levels at the full gain setting were 97.36 dBA and 102.56 dBA for the supra-aural headphones and stock earbuds, respectively. In the noise exposure group, significant changes in hearing thresholds and transient-evoked otoacoustic emission amplitudes were found between preexposure and postexposure measurements. However, this pattern was not seen for distortion product otoacoustic emission amplitudes. Significant differences in the incidence of significant threshold or emission shifts were observed between almost every session of the noise exposure group compared with the control group. Temporary changes in hearing sensitivity measured by audiometry and otoacoustic emissions indicate the potential harmful effects of listening to an MP3 player. Further research is needed to evaluate the long-term risk of cumulative noise exposure on the auditory system of adolescents and adults.

  20. Adolescents Risky MP3-Player Listening and Its Psychosocial Correlates

    Science.gov (United States)

    Vogel, Ineke; Brug, Johannes; Van Der Ploeg, Catharina P. B.; Raat, Hein

    2011-01-01

    Analogue to occupational noise-induced hearing loss, MP3-induced hearing loss may be evolving into a significant social and public health problem. To inform prevention strategies and interventions, this study investigated correlates of adolescents' risky MP3-player listening behavior primarily informed by protection motivation theory. We invited…

  1. Monte Carlo MP2 on Many Graphical Processing Units.

    Science.gov (United States)

    Doran, Alexander E; Hirata, So

    2016-10-11

    In the Monte Carlo second-order many-body perturbation (MC-MP2) method, the long sum-of-product matrix expression of the MP2 energy, whose literal evaluation may be poorly scalable, is recast into a single high-dimensional integral of functions of electron pair coordinates, which is evaluated by the scalable method of Monte Carlo integration. The sampling efficiency is further accelerated by the redundant-walker algorithm, which allows a maximal reuse of electron pairs. Here, a multitude of graphical processing units (GPUs) offers a uniquely ideal platform to expose multilevel parallelism: fine-grain data-parallelism for the redundant-walker algorithm in which millions of threads compute and share orbital amplitudes on each GPU; coarse-grain instruction-parallelism for near-independent Monte Carlo integrations on many GPUs with few and infrequent interprocessor communications. While the efficiency boost by the redundant-walker algorithm on central processing units (CPUs) grows linearly with the number of electron pairs and tends to saturate when the latter exceeds the number of orbitals, on a GPU it grows quadratically before it increases linearly and then eventually saturates at a much larger number of pairs. This is because the orbital constructions are nearly perfectly parallelized on a GPU and thus completed in a near-constant time regardless of the number of pairs. In consequence, an MC-MP2/cc-pVDZ calculation of a benzene dimer is 2700 times faster on 256 GPUs (using 2048 electron pairs) than on two CPUs, each with 8 cores (which can use only up to 256 pairs effectively). We also numerically determine that the cost to achieve a given relative statistical uncertainty in an MC-MP2 energy increases as O(n 3 ) or better with system size n, which may be compared with the O(n 5 ) scaling of the conventional implementation of deterministic MP2. We thus establish the scalability of MC-MP2 with both system and computer sizes.

  2. Sir James Reid and the Death of Queen Victoria: An Early Model for End-of-Life Care.

    Science.gov (United States)

    Abrams, Robert C

    2015-12-01

    An appraisal of the last ten days of Queen Victoria's life, viewed primarily from the perspective of her personal physician, Sir James Reid, is presented. Sir James' clinical encounters with his patient and the Royal Family are examined to reveal his strategic and medical thinking and gauge his level of success in basic palliative aims. It was found that the lack of effective medical interventions, tensions within the Royal Family, the importance of his post to Sir James' professional career, and the political ramifications unavoidably connected with the illness of a head of state, all presented challenges to Reid's efforts to ease the physical and emotional pain of Queen Victoria's dying. Key features of Sir James' approach included reliance on physician-patient and physician-family relationships, emphasis on emotional support for the patient, and the careful selection of interventions for the family. In the first years of the 20th century, an era when the contemporary concepts of palliative care, hospice, and family dynamics did not exist, Sir James' management of the Queen's final illness suggested an early model for end-of-life care. By the end of Queen Victoria's life, Sir James was seen to have preserved his patient's comfort and dignity, at the same time advancing family and societal acceptance of the death of this matriarchal figure. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  3. Arduino-lämpömittari ZigBee-yhteydellä

    OpenAIRE

    Laukkanen, Jani-Pekka

    2013-01-01

    Opinnäytetyön tarkoitus oli toteuttaa lämpötila-anturilla varustettu Arduino, joka lähettää anturin tiedot langattomalla ZigBee-yhteydellä toiselle Arduinolle. Toinen Arduino vastaanottaa datan ja tulostaa sen näytölle. Lämpötila-anturi ja näyttö voivat siis olla fyysisesti eri paikoissa ZigBee-yhteyden kantaman sisällä. Valmis tuotos jäi omaan käyttöön ja sitä käytetään varastotilan lämpötilan seurantaan. Teoriaosuudessa käsiteltiin Arduino-kehitysalustan ja ZigBee-tekniikan perusteita. ...

  4. Haploinsufficiency of TAB2 causes congenital heart defects in humans

    DEFF Research Database (Denmark)

    Thienpont, Bernard; Zhang, Litu; Postma, Alex V

    2010-01-01

    . To definitively confirm the role of this candidate gene in CHDs, we performed mutation analysis of TAB2 in 402 patients with a CHD, which revealed two evolutionarily conserved missense mutations. Finally, a balanced translocation was identified, cosegregating with familial CHD. Mapping of the breakpoints...... demonstrated that this translocation disrupts TAB2. Taken together, these data clearly demonstrate a role for TAB2 in human cardiac development....

  5. Cross Layer Analysis of P2MP Hybrid FSO/RF Network

    KAUST Repository

    Rakia, Tamer

    2017-02-22

    This paper presents and analyzes a point-tomultipoint (P2MP) network that uses a number of freespace optical (FSO) links for data transmission from the central node to the different remote nodes of the network. A common backup radio frequency (RF) link can be used by the central node for data transmission to any remote node in case any one of the FSO links fails. Each remote node is assigned a transmit buffer at the central node. Considering the transmission link from the central node to a tagged remote node, we study various performance metrics. Specifically,we study the throughput from the central node to the tagged node, the average transmit buffer size, the symbol queuing delay in the transmit buffer, the efficiency of the queuing system, the symbol loss probability, and the RF link utilization. Numerical examples are presented to compare the performance of the proposed P2MP hybrid FSO/RF network with that of a P2MP FSO-only network and show that the P2MP hybrid FSO/RF network achieves considerable performance improvement over the P2MP FSO-only network.

  6. SIR - small is safe [in reactor design

    International Nuclear Information System (INIS)

    Hayns, M.

    1989-01-01

    A joint USA-UK venture has been initiated to design a small nuclear reactor which offers low capital cost, greater flexibility and a potentially lower environmental impact. Called Safe Integral Reactor (SIR), the lead unit could be built in the United Kingdom Atomic Energy Authority's (UKAEA's) Winfrith site if the design is accepted by the UK Nuclear Installations Inspectorate (NII). This article describes the 320 MWe reactor unit that is the basis of the design being developed. (author)

  7. Analysis of data acquired by Shuttle Imaging Radar SIR-A and Landsat Thematic Mapper over Baldwin County, Alabama

    Science.gov (United States)

    Wu, S.-T.

    1985-01-01

    Seasonally compatible data collected by SIR-A and by Landsat 4 TM over the lower coastal plain in Alabama were coregistered, forming a SIR-A/TM multichannel data set with 30 m x 30 m pixel size. Spectral signature plots and histogram analysis of the data were used to observe data characteristics. Radar returns from pine forest classes correlated highly with the tree ages, suggesting the potential utility of microwave remote sensing for forest biomass estimation. As compared with the TM-only data set, the use of SIR-A/TM data set improved classification accuracy of the seven land cover types studied. In addition, the SIR-A/TM classified data support previous finding by Engheta and Elachi (1982) that microwave data appear to be correlated with differing bottomland hardwood forest vegetation as associated with varying water regimens (i.e., wet versus dry).

  8. Immunogenicity of a recombinant Rift Valley fever MP-12-NSm deletion vaccine candidate in calves.

    Science.gov (United States)

    Morrill, John C; Laughlin, Richard C; Lokugamage, Nandadeva; Wu, Jing; Pugh, Roberta; Kanani, Pooja; Adams, L Garry; Makino, Shinji; Peters, C J

    2013-10-09

    The safety and immunogenicity of an authentic recombinant (ar) of the live, attenuated MP-12 Rift Valley fever (RVF) vaccine virus with a large deletion of the NSm gene in the pre-Gn region of the M RNA segment (arMP-12ΔNSm21/384) was tested in 4-6 month old Bos taurus calves. Phase I of this study evaluated the neutralizing antibody response, measured by 80% plaque reduction neutralization (PRNT80), and clinical response of calves to doses of 1 × 10(1) through 1 × 10(7) plaque forming units (PFU) administered subcutaneously (s.c.). Phase II evaluated the clinical and neutralizing antibody response of calves inoculated s.c. or intramuscularly (i.m.) with 1 × 10(3), 1 × 10(4) or 1 × 10(5)PFU of arMP-12ΔNSm21/384. No significant adverse clinical events were observed in the animals in these studies. Of all specimens tested, only one vaccine viral isolate was recovered and that virus retained the introduced deletion. In the Phase I study, there was no statistically significant difference in the PRNT80 response between the dosage groups though the difference in IgG response between the 1 × 10(1)PFU group and the 1 × 10(5)PFU group was statistically significant (pPFU dose group showing the least response. The Phase II study also showed no statistically significant difference in PRNT80 response between the dosage groups though the difference in RVFV-specific IgG values was significantly increased (pPFU versus those inoculated s.c. with 1 × 10(3) or 1 × 10(5)PFU. Although the study groups were small, these data suggest that 1 × 10(4) or 1 × 10(5)PFU of arMP-12ΔNSm21/384 administered i.m. to calves will consistently stimulate a presumably protective PRNT80 response for at least 91 days post inoculation. Further studies of arMP-12ΔNSm21/384 are warranted to explore its suitability as an efficacious livestock vaccine. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. Early Experiences Writing Performance Portable OpenMP 4 Codes

    Energy Technology Data Exchange (ETDEWEB)

    Joubert, Wayne [ORNL; Hernandez, Oscar R [ORNL

    2016-01-01

    In this paper, we evaluate the recently available directives in OpenMP 4 to parallelize a computational kernel using both the traditional shared memory approach and the newer accelerator targeting capabilities. In addition, we explore various transformations that attempt to increase application performance portability, and examine the expressiveness and performance implications of using these approaches. For example, we want to understand if the target map directives in OpenMP 4 improve data locality when mapped to a shared memory system, as opposed to the traditional first touch policy approach in traditional OpenMP. To that end, we use recent Cray and Intel compilers to measure the performance variations of a simple application kernel when executed on the OLCF s Titan supercomputer with NVIDIA GPUs and the Beacon system with Intel Xeon Phi accelerators attached. To better understand these trade-offs, we compare our results from traditional OpenMP shared memory implementations to the newer accelerator programming model when it is used to target both the CPU and an attached heterogeneous device. We believe the results and lessons learned as presented in this paper will be useful to the larger user community by providing guidelines that can assist programmers in the development of performance portable code.

  10. The Office for Technology Assessment with the German Parliament (TAB)

    International Nuclear Information System (INIS)

    Grunwald, A.; Petermann, T.

    2004-01-01

    TAB was created in 1990 with the aim of providing contributions to the improvement of the information base, particularly for parliamentary decision-making concerning science and technology. Among TAB's tasks are above all the conception and execution of technology assessment projects and the monitoring and analysis of important scientific and technological trends and related societal developments. TAB is managed by the Institute for Technology Assessment and Systems Analysis (ITAS) of the Karlsruhe Research Center. (orig.)

  11. SIRS score on admission and initial concentration of IL-6 as severe acute pancreatitis outcome predictors.

    Science.gov (United States)

    Gregoric, Pavle; Pavle, Gregoric; Sijacki, Ana; Ana, Sijacki; Stankovic, Sanja; Sanja, Stankovic; Radenkovic, Dejan; Dejan, Radenkovic; Ivancevic, Nenad; Nenad, Ivancevic; Karamarkovic, Aleksandar; Aleksandar, Karamarkovic; Popovic, Nada; Nada, Popovic; Karadzic, Borivoje; Borivoje, Karadzic; Stijak, Lazar; Stefanovic, Branislav; Branislav, Stefanovic; Milosevic, Zoran; Zoran, Milosević; Bajec, Djordje; Djordje, Bajec

    2010-01-01

    Early recognition of severe form of acute pancreatitis is important because these patients need more agressive diagnostic and therapeutical approach an can develope systemic complications such as: sepsis, coagulopathy, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Dysfunction Syndrome (MODS), Multiple Organ Failure (MOF). To determine role of the combination of Systemic Inflammatory Response Syndrome (SIRS) score and serum Interleukin-6 (IL-6) level on admission as predictor of illness severity and outcome of Severe Acute Pancreatitis (SAP). We evaluated 234 patients with first onset of SAP appears in last twenty four hours. A total of 77 (33%) patients died. SIRS score and serum IL-6 concentration were measured in first hour after admission. In 105 patients with SIRS score 3 and higher, initial measured IL-6 levels were significantly higher than in the group of remaining 129 patients (72 +/- 67 pg/mL, vs 18 +/- 15 pg/mL). All nonsurvivals were in the first group, with SIRS score 3 and 4 and initial IL-6 concentration 113 +/- 27 pg/mL. The values of C-reactive Protein (CRP) measured after 48h, Acute Physiology and Chronic Health Evaluation (APACHE II) score on admission and Ranson score showed the similar correlation, but serum amylase level did not correlate significantly with Ranson score, IL-6 concentration and APACHE II score. The combination of SIRS score on admission and IL-6 serum concentration can be early, predictor of illness severity and outcome in SAP.

  12. Performance monitoring and analysis of task-based OpenMP.

    Directory of Open Access Journals (Sweden)

    Yi Ding

    Full Text Available OpenMP, a typical shared memory programming paradigm, has been extensively applied in high performance computing community due to the popularity of multicore architectures in recent years. The most significant feature of the OpenMP 3.0 specification is the introduction of the task constructs to express parallelism at a much finer level of detail. This feature, however, has posed new challenges for performance monitoring and analysis. In particular, task creation is separated from its execution, causing the traditional monitoring methods to be ineffective. This paper presents a mechanism to monitor task-based OpenMP programs with interposition and proposes two demonstration graphs for performance analysis as well. The results of two experiments are discussed to evaluate the overhead of monitoring mechanism and to verify the effects of demonstration graphs using the BOTS benchmarks.

  13. Identification and functional characterization of the TAB2 gene from Litopenaeus vannamei.

    Science.gov (United States)

    Wang, Sheng; Li, Haoyang; Qian, Zhe; Song, Xuan; Zhang, Zijian; Zuo, Hongliang; Xu, Xiaopeng; Weng, Shaoping; He, Jianguo; Li, Chaozheng

    2015-10-01

    In Drosophila, TAB2, an important intermediate in the IMD signaling pathway, plays critical roles in the innate immune response in response to bacterial and viral infection. However, the role of TAB-related proteins in the immune response of shrimp has not yet been established. Here, we reported the identification of a TAB2-like gene in Litopenaeus vannamei designated as LvTAB2. The full-length cDNA of LvTAB2 was 2160 bp with an open reading frame of 1827 bp, which encoded a putative protein of 608 amino acids including a ubiquitin binding domain (CUE) at the N-terminal and a Zinc Finger domain (ZnF) at the C-terminus. Real-time RT-PCR analysis showed that LvTAB2 was expressed in all tested tissues and the expression levels of LvTAB2 in gills and hemocytes were positively induced in response to LPS, Vibrio parahemolyticus and White Spot Syndrome Virus (WSSV) challenges. Dual luciferase reporter assays demonstrated that LvTAB2 was able to induce the expression of antimicrobial peptide (AMP) genes, including Drosophila Attacin A and shrimp Penaeidins. Interestingly, over-expression of LvTAB2 could up-regulate the promoter activities of L. vannamei Vago1, Vago3 and Vago4 genes in S2 cells. To our knowledge, it was the first report that TAB2 participated in innate immune signaling to regulate the expression of Vago genes in invertebrates. Moreover, RNAi-mediated knockdown of LvTAB2 enhanced sensitivity of L. vannamei to Vibrio parahaemolyticus infection and caused elevated virus loads after WSSV infection. We suggested that the LvTAB2 may play important roles in the shrimp innate immunity. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Yeast Tdh3 (glyceraldehyde 3-phosphate dehydrogenase is a Sir2-interacting factor that regulates transcriptional silencing and rDNA recombination.

    Directory of Open Access Journals (Sweden)

    Alison E Ringel

    Full Text Available Sir2 is an NAD(+-dependent histone deacetylase required to mediate transcriptional silencing and suppress rDNA recombination in budding yeast. We previously identified Tdh3, a glyceraldehyde 3-phosphate dehydrogenase (GAPDH, as a high expression suppressor of the lethality caused by Sir2 overexpression in yeast cells. Here we show that Tdh3 interacts with Sir2, localizes to silent chromatin in a Sir2-dependent manner, and promotes normal silencing at the telomere and rDNA. Characterization of specific TDH3 alleles suggests that Tdh3's influence on silencing requires nuclear localization but does not correlate with its catalytic activity. Interestingly, a genetic assay suggests that Tdh3, an NAD(+-binding protein, influences nuclear NAD(+ levels; we speculate that Tdh3 links nuclear Sir2 with NAD(+ from the cytoplasm.

  15. Investigating The Travelling Wave Solution For an SIR Endemic ...

    African Journals Online (AJOL)

    This paper presents the travelling wave solution for an SIR endemic disease model with no disease related death when the spatial spread of the susceptible is not negligible. In this case the disease is driven by both the susceptible and the infective classes. The population is open since the disease is habitually prevalent in ...

  16. Optimising preoperative risk stratification tools for prostate cancer using mpMRI

    Energy Technology Data Exchange (ETDEWEB)

    Reisaeter, Lars A.R.; Losnegaard, Are; Biermann, Martin; Roervik, Jarle [Haukeland University Hospital, Department of Radiology, Bergen (Norway); University of Bergen, Department of Clinical Medicine, Bergen (Norway); Fuetterer, Jurgen J. [Radboud University Nijmegen Medical Centre, Department of Radiology, Nijmegen (Netherlands); Nygaard, Yngve [Haukeland University Hospital, Department of Urology, Bergen (Norway); Monssen, Jan [Haukeland University Hospital, Department of Radiology, Bergen (Norway); Gravdal, Karsten [Haukeland University Hospital, Department of Pathology, Bergen (Norway); Halvorsen, Ole J.; Akslen, Lars A. [Haukeland University Hospital, Department of Pathology, Bergen (Norway); Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen (Norway); Haukaas, Svein; Beisland, Christian [University of Bergen, Department of Clinical Medicine, Bergen (Norway); Haukeland University Hospital, Department of Urology, Bergen (Norway)

    2018-03-15

    To improve preoperative risk stratification for prostate cancer (PCa) by incorporating multiparametric MRI (mpMRI) features into risk stratification tools for PCa, CAPRA and D'Amico. 807 consecutive patients operated on by robot-assisted radical prostatectomy at our institution during the period 2010-2015 were followed to identify biochemical recurrence (BCR). 591 patients were eligible for final analysis. We employed stepwise backward likelihood methodology and penalised Cox cross-validation to identify the most significant predictors of BCR including mpMRI features. mpMRI features were then integrated into image-adjusted (IA) risk prediction models and the two risk prediction tools were then evaluated both with and without image adjustment using receiver operating characteristics, survival and decision curve analyses. 37 patients suffered BCR. Apparent diffusion coefficient (ADC) and radiological extraprostatic extension (rEPE) from mpMRI were both significant predictors of BCR. Both IA prediction models reallocated more than 20% of intermediate-risk patients to the low-risk group, reducing their estimated cumulative BCR risk from approximately 5% to 1.1%. Both IA models showed improved prognostic performance with a better separation of the survival curves. Integrating ADC and rEPE from mpMRI of the prostate into risk stratification tools improves preoperative risk estimation for BCR. (orig.)

  17. Everyday music listening and affect regulation: The role of MP3 players

    Directory of Open Access Journals (Sweden)

    Marie Strand Skånland

    2013-08-01

    Full Text Available The use of digital portable music devices such as MP3 players has rapidly increased during the last decade, and the sheer availability of music offered by such players raises questions about their impact on listeners’ mental and physical health and well-being. This article explores MP3 player use as an everyday tactic for affect regulation, here understood as an individual's efforts to maintain or change the intensity or duration of a given affect. The ability to understand and regulate affects has significant health implications, and among the tactics relevant to such regulation, engagement with music has proven to be particularly successful. The material presented in this article is based on a qualitative interview study focused on MP3 player use as a medium for musical self-care. Because MP3 users can listen to whatever they want, whenever they want, and target their music in the interests of managing and regulating moods and emotions, the MP3 player represents a valuable and convenient technology of affect regulation.

  18. Everyday music listening and affect regulation: the role of MP3 players.

    Science.gov (United States)

    Skånland, Marie Strand

    2013-08-07

    The use of digital portable music devices such as MP3 players has rapidly increased during the last decade, and the sheer availability of music offered by such players raises questions about their impact on listeners' mental and physical health and well-being. This article explores MP3 player use as an everyday tactic for affect regulation, here understood as an individual's efforts to maintain or change the intensity or duration of a given affect. The ability to understand and regulate affects has significant health implications, and among the tactics relevant to such regulation, engagement with music has proven to be particularly successful. The material presented in this article is based on a qualitative interview study focused on MP3 player use as a medium for musical self-care. Because MP3 users can listen to whatever they want, whenever they want, and target their music in the interests of managing and regulating moods and emotions, the MP3 player represents a valuable and convenient technology of affect regulation.

  19. Buffels (Wes), Elsies, Sir Lowry's pass, Steenbras and Buffels (Oos)

    CSIR Research Space (South Africa)

    Heinecken, TJE

    1982-06-01

    Full Text Available This report is a synthesis of all available information on five of the smaller rivers discharging in to False bay combined as a single volume. The rivers dealt with are the Buffels (Wes), Elsies, Sir Lowry' Pass, Steenbras and Buffels (Oos). False...

  20. Rift Valley fever virus MP-12 vaccine encoding Toscana virus NSs retains neuroinvasiveness in mice.

    Science.gov (United States)

    Indran, Sabarish V; Lihoradova, Olga A; Phoenix, Inaia; Lokugamage, Nandadeva; Kalveram, Birte; Head, Jennifer A; Tigabu, Bersabeh; Smith, Jennifer K; Zhang, Lihong; Juelich, Terry L; Gong, Bin; Freiberg, Alexander N; Ikegami, Tetsuro

    2013-07-01

    Rift Valley fever is a mosquito-borne zoonotic disease endemic to sub-Saharan Africa. Rift Valley fever virus (RVFV; genus Phlebovirus, family Bunyaviridae) causes high rates of abortion and fetal malformation in pregnant ruminants, and haemorrhagic fever, neurological disorders or blindness in humans. The MP-12 strain is a highly efficacious and safe live-attenuated vaccine candidate for both humans and ruminants. However, MP-12 lacks a marker to differentiate infected from vaccinated animals. In this study, we originally aimed to characterize the efficacy of a recombinant RVFV MP-12 strain encoding Toscana virus (TOSV) NSs gene in place of MP-12 NSs (rMP12-TOSNSs). TOSV NSs promotes the degradation of dsRNA-dependent protein kinase (PKR) and inhibits interferon-β gene up-regulation without suppressing host general transcription. Unexpectedly, rMP12-TOSNSs increased death in vaccinated outbred mice and inbred BALB/c or C57BL/6 mice. Immunohistochemistry showed diffusely positive viral antigens in the thalamus, hypothalamus and brainstem, including the medulla. No viral antigens were detected in spleen or liver, which is similar to the antigen distribution of moribund mice infected with MP-12. These results suggest that rMP12-TOSNSs retains neuroinvasiveness in mice. Our findings demonstrate that rMP12-TOSNSs causes neuroinvasion without any hepatic disease and will be useful for studying the neuroinvasion mechanism of RVFV and TOSV.

  1. Simulation of emotional contagion using modified SIR model: A cellular automaton approach

    Science.gov (United States)

    Fu, Libi; Song, Weiguo; Lv, Wei; Lo, Siuming

    2014-07-01

    Emotion plays an important role in the decision-making of individuals in some emergency situations. The contagion of emotion may induce either normal or abnormal consolidated crowd behavior. This paper aims to simulate the dynamics of emotional contagion among crowds by modifying the epidemiological SIR model to a cellular automaton approach. This new cellular automaton model, entitled the “CA-SIRS model”, captures the dynamic process ‘susceptible-infected-recovered-susceptible', which is based on SIRS contagion in epidemiological theory. Moreover, in this new model, the process is integrated with individual movement. The simulation results of this model show that multiple waves and dynamical stability around a mean value will appear during emotion spreading. It was found that the proportion of initial infected individuals had little influence on the final stable proportion of infected population in a given system, and that infection frequency increased with an increase in the average crowd density. Our results further suggest that individual movement accelerates the spread speed of emotion and increases the stable proportion of infected population. Furthermore, decreasing the duration of an infection and the probability of reinfection can markedly reduce the number of infected individuals. It is hoped that this study will be helpful in crowd management and evacuation organization.

  2. A Role for MEK-Interacting Protein 1 In Hormone Responsiveness of ER Positive Breast Cancer Cells

    Science.gov (United States)

    2011-10-01

    48 hours, ER- positiv e cell lines tran sfected with MP1siRNA (but not control siR NA) rounded up and detached fr om the plate, and trypan blue...phenotype to MCF-7. To quantitate the effect of MP1 knockdown, attached and detached cells were collected at 48 h following siRNA transfection, stained...Immunoblot from a representative experiment. Lower panel: Quantitation of MP1/Actin ratios in three independent experiments (mean ± SD, *pɘ.05). Figure

  3. Le continent noir du désir masculin : Colet et Flaubert, encore

    OpenAIRE

    Vinken, Barbara

    2010-01-01

    Il y a peu d’échanges de lettres qui surprennent le lecteur aussi douloureusement que celui entre Louise Colet et Gustave Flaubert. Rarement, l’espoir qui sommeille au fond de tout lecteur d’une histoire d’amour heureux fut à ce point frustré.Les études de Freud – un des plus grands sceptiques en matière d’amour – sur la vie sexuelle éclairent les vicissitudes du désir amoureux masculin. Les Lettres de Flaubert à Colet sont la mise en scène dramatique d’un désir qui suit les complications du ...

  4. Mp3 Player Applications Using Microsoft Visual Basic 6.0 Interface with Windows Media Player Format

    OpenAIRE

    Supriyono Supriyono; Ir. Fitri Sjafrina, MM

    2002-01-01

    Multimedia technology, MP3 (MPEG Audio Layer-3) is someone that a storage ofmusic in digital form offers many advantages compared to analog form. MP3 Playeris a media used for computer users who like the music, especially MP3.MP3 is a digital audio compression standard developed by the Institute and ThomsonMultimedia Freunhofer. With MP3, a digital music that can be encoded into a tenkaliatau reduced in size even more by simply reducing the existing sound quality.Although the interface of Win...

  5. BOREAS RSS-15 SIR-C and Landsat TM Biomass and Landcover Maps of the NSA

    Science.gov (United States)

    Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Ranson, K. Jon

    2000-01-01

    As part of BOREAS, the RSS-15 team conducted an investigation using SIR-C, X-SAR, and Landsat TM data for estimating total above-ground dry biomass for the SSA and NSA modeling grids and component biomass for the SSA. Relationships of backscatter to total biomass and total biomass to foliage, branch, and bole biomass were used to estimate biomass density across the landscape. The procedure involved image classification with SAR and Landsat TM data and development of simple mapping techniques using combinations of SAR channels. For the SSA, the SIR-C data used were acquired on 06-Oct-1994, and the Landsat TM data used were acquired on 02-Sep-1995. The maps of the NSA were developed from SIR-C data acquired on 13-Apr-1994. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  6. Adolescents and MP3 players: too many risks, too few precautions.

    Science.gov (United States)

    Vogel, Ineke; Verschuure, Hans; van der Ploeg, Catharina P B; Brug, Johannes; Raat, Hein

    2009-06-01

    The goal was to assess risky and protective listening behaviors of adolescent users of MP3 players and the association of these behaviors with demographic characteristics and frequency of use. In 2007, 1687 adolescents (12-19 years of age) in 68 classes in 15 Dutch secondary schools were invited to complete questionnaires about their music-listening behaviors. . Ninety percent of participants reported listening to music through earphones on MP3 players; 32.8% were frequent users, 48.0% used high volume settings, and only 6.8% always or nearly always used a noise-limiter. Frequent users were >4 times more likely to listen to high-volume music than were infrequent users, and adolescents in practical prevocational schools were more than twice as likely to listen to high-volume music as were those attending preuniversity education. When using MP3 players, adolescents are very likely to engage in risky listening behaviors and are unlikely to seek protection. Frequent MP3 player use is an indicator of other risky listening behaviors, such as listening at high volumes and failing to use noise-limiters.

  7. MP3 the meaning of a format

    CERN Document Server

    Sterne, Jonathan

    2012-01-01

    Jonathan Sterne shows that understanding the historical meaning of the MP3, the world's most common format for recorded audio, involves rethinking the place of digital technologies in the broader universe of twentieth-century communication history.

  8. Quantitative measurement of Y90 brehmmstrahlung images after of Y90 Sir-Spheres implantation to assess lung shunting

    International Nuclear Information System (INIS)

    Forwood, Nicholas J.; Pocock, Nicholas; Shin, Jane; Young, Andy M; Szeto, Edwin R.

    2009-01-01

    Full text: Background: In clinical practice the dose of Y 9 0 Sir-Spheres is calculated using a pre injection of Tc 9 9 m MAA. There is however a potential difference due to the different properties of Tc 9 9 m MAA and Y 9 0 Sir-Spheres. We assessed the concordance of lung shunting of Y 9 0 Sir-Spheres estimated using Y 9 0 Bremsstrahlung imaging, compared to shunting assessed using Tc 9 9 m MAA. Methods: 15 Patients were evaluated using 150-200 MBq of Tc 9 9 m MAA injected into the hepatic artery under angiographic guidance. Whole body images were acquired using a LEAP collimator (window of 140 kEv+/-10%). The patients were subsequently treated with Y 9 0 Sir-Spheres. After microspheres injection, whole body brehmsstrahlung images were acquired using a medium energy collimator (window settings of 75 kEv +/- 20%). Tc 9 9 m MAA images were paired with their corresponding bremsstrahlung image and lung shunting in the stu ides calculated simultaneously. Each paired dataset was analyzed by 5 operators. Results: The mean lung shunting for Tc 9 9 m MAA acquisition was 3.32% (SD 2.03) which was significantly lower than the lung shunting using the Y 9 0 acquisitions: mean 16.19% (SD of 6.43). The Pearson coefficient was r = 0.62 (p 9 0 Sir-Spheres bremsstrahlung imaging is higher than that calculated by Tc 9 9 m MAA imaging. The relationship is not sufficiently strong to use bremsstahlung imaging to retrospectively quantify the lung-to-liver shunting as indicated using Tc 9 9 M AA. Further studies are underway to assess the reliability of Tc 9 9 m MAA lung uptake calculations in determining the dose of Y 9 0 Sir-Spheres.

  9. Milestones in plant sulfur research on sulfur-induced-resistance (SIR in Europe

    Directory of Open Access Journals (Sweden)

    Elke eBloem

    2015-01-01

    Full Text Available Until the 1970´s of the last century sulfur (S was mainly regarded as a pollutant being the main contributor of acid rain, causing forest dieback in central Europe. When Clean Air Acts came into force at the start of the 1980´s SO2 contaminations in the air were consequently reduced within the next years. S changed from an unwanted pollutant into a lacking plant nutrient in agriculture since agricultural fields were no longer fertilized indirectly by industrial pollution. S deficiency was first noticed in Brassica crops that display an especially high S demand because of its content of S-containing secondary metabolites, the glucosinolates. In Scotland, where S depositions decreased even faster than in continental Europe, an increasing disease incidence with Pyrenopeziza brassicae was observed in oilseed rape in the beginning 1990´s and the concept of sulfur-induced-resistance (SIR was developed after a relationship between the S status and the disease incidence was uncovered. Since then a lot of research was carried out to unravel the background of SIR in the metabolism of agricultural crops and to identify metabolites, enzymes and reactions, which are potentially activated by the S metabolism to combat fungal pathogens. The S status of the crop is affecting many different plant features such as color and scent of flowers, pigments in leaves, metabolite concentrations and the release of gaseous S compounds which are directly influencing the desirability of a crop for a variety of different organisms from microorganisms, over insects and slugs to the point of grazing animals.The present paper is an attempt to sum up the knowledge about the effect of the S nutritional status of agricultural crops on parameters that are directly related to their health status and by this to SIR. Milestones in SIR research are compiled, open questions are addressed and future projections were developed.

  10. Does SOFA predict outcomes better than SIRS in Brazilian ICU patients with suspected infection? A retrospective cohort study

    Directory of Open Access Journals (Sweden)

    Regis Goulart Rosa

    2017-11-01

    Full Text Available We compared the discriminatory capacity of the sequential organ failure assessment (SOFA versus the systemic inflammatory response syndrome (SIRS score for predicting ICU mortality, need for and length of mechanical ventilation, ICU stay, and hospitalization in patients with suspected infection admitted to a mixed Brazilian ICU. We performed a retrospective analysis of a longitudinal ICU database from a tertiary hospital in Southern Brazil. Patients were categorized according to whether they met the criteria for sepsis according to SOFA (variation ≥2 points over the baseline clinical condition and SIRS (SIRS score ≥2 points. From January 2008 to December 2014, 1487 patients were admitted to the ICU due to suspected infection. SOFA ≥2 identified more septic patients than SIRS ≥2 (79.0% [n = 1175] vs. 68.5% [n = 1020], p  7 days (AUROC = 0.65 vs. 0.63, p = 0.004, and length of hospitalization >10 days (AUROC = 0.61 vs. 0.59, p 7 days.

  11. Atomic orbital-based SOS-MP2 with tensor hypercontraction. II. Local tensor hypercontraction

    Science.gov (United States)

    Song, Chenchen; Martínez, Todd J.

    2017-01-01

    In the first paper of the series [Paper I, C. Song and T. J. Martinez, J. Chem. Phys. 144, 174111 (2016)], we showed how tensor-hypercontracted (THC) SOS-MP2 could be accelerated by exploiting sparsity in the atomic orbitals and using graphical processing units (GPUs). This reduced the formal scaling of the SOS-MP2 energy calculation to cubic with respect to system size. The computational bottleneck then becomes the THC metric matrix inversion, which scales cubically with a large prefactor. In this work, the local THC approximation is proposed to reduce the computational cost of inverting the THC metric matrix to linear scaling with respect to molecular size. By doing so, we have removed the primary bottleneck to THC-SOS-MP2 calculations on large molecules with O(1000) atoms. The errors introduced by the local THC approximation are less than 0.6 kcal/mol for molecules with up to 200 atoms and 3300 basis functions. Together with the graphical processing unit techniques and locality-exploiting approaches introduced in previous work, the scaled opposite spin MP2 (SOS-MP2) calculations exhibit O(N2.5) scaling in practice up to 10 000 basis functions. The new algorithms make it feasible to carry out SOS-MP2 calculations on small proteins like ubiquitin (1231 atoms/10 294 atomic basis functions) on a single node in less than a day.

  12. North-American MP Tandem accelerators

    International Nuclear Information System (INIS)

    Wegner, H.E.; Thieberger, P.

    1977-01-01

    There are six North-American MP Tandem accelerators: Yale; Minnesota; Chalk River; Rochester; and two at Brookhaven. The current status and operating characteristics of these six tandem accelerators are discussed. Upgrade and special improvements of the different machines is reviewed and new developments since the last Electrostatic Conference are discussed in detail. The overall operating characteristics of the different machines during the last year of operation are compared

  13. Multi-core job submission and grid resource scheduling for ATLAS AthenaMP

    CERN Document Server

    Crooks, D; The ATLAS collaboration; Harrington, R; Purdie, S; Severini, H; Skipsey, S; Tsulaia, V; Washbrook, A

    2012-01-01

    AthenaMP is the multi-core implementation of the ATLAS software framework and allows the efficient sharing of memory pages between multiple threads of execution. This has now been validated for production and delivers a significant reduction on overall memory footprint with negligible CPU overhead. Before AthenaMP can be routinely run on the LHC Computing Grid, it must be determined how the computing resources available to ATLAS can best exploit the notable improvements delivered by switching to this multi-process model. In particular, there is a need to identify and assess the potential impact of scheduling issues where single core and multi-core job queues have access to the same underlying resources. A study into the effectiveness and scalability of AthenaMP in a production environment will be presented. Submitting AthenaMP tasks to the Tier-0 and candidate Tier-2 sites will allow detailed measurement of worker node performance and also highlight the relative performance of local resource management system...

  14. The use of MP3 recorders to log data from equine hoof mounted accelerometers.

    Science.gov (United States)

    Parsons, K J; Wilson, A M

    2006-11-01

    MP3 recorders are readily available, small, lightweight and low cost, providing the potential for logging analogue hoof mounted accelerometer signals for the characterisation of equine locomotion. These, however, require testing in practice. To test whether 1) multiple MP3 recorders can maintain synchronisation, giving the ability to synchronise independent recorders for the logging of multiple limbs simultaneously; and 2) features of a foot mounted accelerometer signal attributable to foot-on and foot-off can be accurately identified from horse foot mounted accelerometers logged directly into an MP3 recorder. Three experiments were performed: 1) Maintenance of synchronisation was assessed by counting the number of samples recorded by each of 4 MP3 recorders while mounted on a trotting horse and over 2 consecutive 30 min periods in 8 recorders on a bench. 2) Foot-on and foot-off times obtained from manual transcription of MP3 logged data and directly logged accelerometer signal were compared. 3) MP3/accelerometer acquisition units were used to log accelerometer signals from racehorses during extended training sessions. Mean absolute error of synchronisation between MP3 recorders was 10 samples per million (compared to mean number of samples, range 1-32 samples per million). Error accumulation showed a linear correlation with time. Features attributable to foot on and foot off were equally identifiable from the MP3 recorded signal over a range of equine gaits. Multiple MP3 recorders can be synchronised and used as a relatively cheap, robust, reliable and accurate logging system when combined with an accelerometer and external battery for the specific application of the measurement of stride timing variables across the range of equine gaits during field locomotion. Footfall timings can be used to identify intervals between the fore and hind contacts, the identification of diagonal advanced placement and to calculate stride timing variables (stance time, protraction

  15. [Hearing the impact of MP3 on a survey of middle school students].

    Science.gov (United States)

    Xu, Zhan; Li, Zonghua; Chen, Yang; He, Ya; Chunyu, Xiujie; Wang, Fangyuan; Zhang, Pengzhi; Gao, Lei; Qiu, Shuping; Liu, Shunli; Qiao, Li; Qiu, Jianhua

    2011-02-01

    To understand the usage of MP3 and effects on hearing of middle school students in Xi'an, and discuss controlling strategies. Stratified random cluster sampling method was used in the 1567 middle school students in Xi'an through questionnaire survey, ear examination and hearing examination, data were analysed by the SPSS13.0 statistical software. 1) The rate of holding MP3 in the middle school students was 85.2%. Average daily use time was (1.41 +/- 1.11) h. 2) The noise group of pure tone hearing threshold was significantly higher compared with the control group (PMP3. 3) The detection rate of symptoms increased with the increasing use of MP3. The usage of MP3 can harm hearing in middle school students, which can result in neurasthenic syndrome.

  16. Execution Model of Three Parallel Languages: OpenMP, UPC and CAF

    Directory of Open Access Journals (Sweden)

    Ami Marowka

    2005-01-01

    Full Text Available The aim of this paper is to present a qualitative evaluation of three state-of-the-art parallel languages: OpenMP, Unified Parallel C (UPC and Co-Array Fortran (CAF. OpenMP and UPC are explicit parallel programming languages based on the ANSI standard. CAF is an implicit programming language. On the one hand, OpenMP designs for shared-memory architectures and extends the base-language by using compiler directives that annotate the original source-code. On the other hand, UPC and CAF designs for distribute-shared memory architectures and extends the base-language by new parallel constructs. We deconstruct each language into its basic components, show examples, make a detailed analysis, compare them, and finally draw some conclusions.

  17. CHaMP metrics - Columbia Habitat Monitoring Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The goal of CHaMP is to generate and implement a standard set of fish habitat monitoring (status and trend) methods in up to 26 watersheds across the Columbia River...

  18. [Sir Geoffrey Keynes 1887-1982. Surgical pioneer, medical historian, humanist].

    Science.gov (United States)

    Bergljung, Lars

    2005-01-01

    Sir Geoffrey Keynes (1887 - 1982), was a pioneer in the surgery of breast cancer and thymic deseases, n.b. in patients suffering from myastenia gravis. He strongly disapproved of the longstanding dogma of so called radical mastectomy in breast cancer, and advocated a more limited surgical approach, followed by radiation therapy. This was done more than fifty years before breastconserving surgery has become the therapy of choice and against considerable opposition from the surgical establishment of his days. He also became a pioneer in the surgical treatment of myastenia gravis by thymectomy, at a time when there was no real understanding of the pathophysiology of the disease and when considerable controversy existed as to the importance or non importance of concomitant tumour formation in the thymus. Besides being a busy surgeon Sir Geoffrey was a medical historian, writing the biography of among others William Harvey, a bibliographer with a special interest in the poet and artist William Blake and a bibliophil with a large book collection of great value to medical history.

  19. Association of Finnish Members of Parliament and Researchers: Social Democratic Parliamentary group MP K. Olin, Former Finnish MP M. Tiuri, Finnish Centre Party MP P. Vilkuna, Senior Assistant Professor I. Ruostetsaari and Finnish Parliament Committee of Future Researcher U. Gabrielsson at ATLAS experiment with P. Jenn, M. Nordberg and M. Kotamaki on 15 September 2006.

    CERN Document Server

    Maximilien Brice

    2006-01-01

    Association of Finnish Members of Parliament and Researchers: Social Democratic Parliamentary group MP K. Olin, Former Finnish MP M. Tiuri, Finnish Centre Party MP P. Vilkuna, Senior Assistant Professor I. Ruostetsaari and Finnish Parliament Committee of Future Researcher U. Gabrielsson at ATLAS experiment with P. Jenn, M. Nordberg and M. Kotamaki on 15 September 2006.

  20. Multi-core job submission and grid resource scheduling for ATLAS AthenaMP

    CERN Multimedia

    CERN. Geneva

    2012-01-01

    A study into the effectiveness and scalability of AthenaMP in a production environment will be presented. Submitting AthenaMP tasks to the Tier-0 and candidate Tier-2 sites will allow detailed measurement of worker node performance and also highlight the relative performance of local resource management system...

  1. PALEODRAINAGES OF THE EASTERN SAHARA - THE RADAR RIVERS REVISITED (SIR - A/B IMPLICATIONS FOR A MID - TERTIARY TRANS - AFRICAN DRAINAGE SYSTEM).

    Science.gov (United States)

    McCauley, John F.; Breed, Carlos S.; Schaber, Gerald G.; McHugh, William P.; Issawi, Bahay; Haynes, C. Vance; Grolier, Maurice J.; El Kilani, Ali

    1986-01-01

    A complex history of Cenozoic fluvial activity in the presently hyperarid eastern Sahara is inferred from Shuttle Imaging Radar (SIR) data and postflight field investigations in southwest Egypt and northwest Sudan. SIR images were coregistered with Landsat and existing maps as a guide to exploration of the buried paleodrainages (radar rivers) first discovered by SIR-A. Field observations explain the radar responses of three types of radar rivers: RR-1, RR-2, and RR-3. A generalized model of the radar rivers, based on field studies and regional geologic relations, shows apparent changes in river regimen since the large valleys were established during the late Paleogene-early Neogene eras. SIR-based mapping of these paleodrainages, although incomplete, reveals missing links in an area once thought to be devoid of master streams.

  2. Benchmarking and Evaluating Unified Memory for OpenMP GPU Offloading

    Energy Technology Data Exchange (ETDEWEB)

    Mishra, Alok [Stony Brook Univ., Stony Brook, NY (United States); Li, Lingda [Brookhaven National Lab. (BNL), Upton, NY (United States); Kong, Martin [Brookhaven National Lab. (BNL), Upton, NY (United States); Finkel, Hal [Argonne National Lab. (ANL), Argonne, IL (United States); Chapman, Barbara [Stony Brook Univ., Stony Brook, NY (United States); Brookhaven National Lab. (BNL), Upton, NY (United States)

    2017-01-01

    Here, the latest OpenMP standard offers automatic device offloading capabilities which facilitate GPU programming. Despite this, there remain many challenges. One of these is the unified memory feature introduced in recent GPUs. GPUs in current and future HPC systems have enhanced support for unified memory space. In such systems, CPU and GPU can access each other's memory transparently, that is, the data movement is managed automatically by the underlying system software and hardware. Memory over subscription is also possible in these systems. However, there is a significant lack of knowledge about how this mechanism will perform, and how programmers should use it. We have modified several benchmarks codes, in the Rodinia benchmark suite, to study the behavior of OpenMP accelerator extensions and have used them to explore the impact of unified memory in an OpenMP context. We moreover modified the open source LLVM compiler to allow OpenMP programs to exploit unified memory. The results of our evaluation reveal that, while the performance of unified memory is comparable with that of normal GPU offloading for benchmarks with little data reuse, it suffers from significant overhead when GPU memory is over subcribed for benchmarks with large amount of data reuse. Based on these results, we provide several guidelines for programmers to achieve better performance with unified memory.

  3. Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

    Energy Technology Data Exchange (ETDEWEB)

    Samat, N. A.; Ma' arof, S. H. Mohd Imam [Department of Mathematics, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjung Malim, Perak (Malaysia)

    2014-12-04

    This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.

  4. Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

    International Nuclear Information System (INIS)

    Samat, N. A.; Ma'arof, S. H. Mohd Imam

    2014-01-01

    This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases

  5. Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

    Science.gov (United States)

    Samat, N. A.; Ma'arof, S. H. Mohd Imam

    2014-12-01

    This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.

  6. On the Shoulders of Sir Isaac Newton and Arthur Storer

    Science.gov (United States)

    Martin, Helen E.; Evans-Gondo, Bonita

    2013-01-01

    Helen E. Martin, the author of this article, is a retired National Board Certified Teacher who has been researching Sir Isaac Newton's unpublished manuscripts for over three decades. While researching the work of Newton, a teacher she was mentoring asked for some hands-on activities to study planetary motion. The description of the activity…

  7. [Sir Harold Ridley--the creator of modern cataract surgery].

    Science.gov (United States)

    Obuchowska, Iwona; Mariak, Zofia

    2005-01-01

    In February 2000, the worldwide ophthalmology community celebrated the 50th anniversary of one of the twentieth century's most important innovations in eye care--the implantation of the first intraocular lens after cataract extraction by Sir Harold Ridley. It was the initiation of a golden age for the development of ophthalmology, especially cataract surgery. In our paper we would like to remember this outstanding English ophthalmologist and his great invention.

  8. Sir Peter Medawar: science, creativity and the popularization of Karl Popper

    Science.gov (United States)

    Calver, Neil

    2013-01-01

    Sir Peter Medawar was respected by scientists and literati alike. It was perhaps not surprising, then, that he would choose to involve himself in the ‘two cultures’ debate of 1959 and beyond. The focus of his intervention was the philosophy of Sir Karl Popper. However, Medawar's Popper was not the guru of falsification familiar from philosophy textbooks. Medawar's distinctive interpretation of Popper treated him instead as the source of insights into the role of creativity and imagination in scientific inquiry. This paper traces the context for Medawar's adoption of Popperian philosophy, together with its application before the debate. It then examines, within the context of the debate itself, the way in which Medawar attempted to reconcile scientific inquiry with literary practice. Medawar became increasingly convinced that not only was induction epistemologically unsound, but it was also damaging to the public role of the scientist. His construction of Popperianism would, he envisaged, provide a worthy alternative for scientists’ self-image.

  9. Monitoring of the data processing and simulated production at CMS with a web-based service: the Production Monitoring Platform (pMp)

    Science.gov (United States)

    Franzoni, G.; Norkus, A.; Pol, A. A.; Srimanobhas, N.; Walker, J.

    2017-10-01

    Physics analysis at the Compact Muon Solenoid requires both the production of simulated events and processing of the data collected by the experiment. Since the end of the LHC Run-I in 2012, CMS has produced over 20 billion simulated events, from 75 thousand processing requests organised in one hundred different campaigns. These campaigns emulate different configurations of collision events, the detector, and LHC running conditions. In the same time span, sixteen data processing campaigns have taken place to reconstruct different portions of the Run-I and Run-II data with ever improving algorithms and calibrations. The scale and complexity of the events simulation and processing, and the requirement that multiple campaigns must proceed in parallel, demand that a comprehensive, frequently updated and easily accessible monitoring be made available. The monitoring must serve both the analysts, who want to know which and when datasets will become available, and the central production teams in charge of submitting, prioritizing, and running the requests across the distributed computing infrastructure. The Production Monitoring Platform (pMp) web-based service, has been developed in 2015 to address those needs. It aggregates information from multiple services used to define, organize, and run the processing requests. Information is updated hourly using a dedicated elastic database and the monitoring provides multiple configurable views to assess the status of single datasets as well as entire production campaigns. This contribution will describe the pMp development, the evolution of its functionalities, and one and half year of operational experience.

  10. Sir James Paget: Paget's disease of the nipple, Paget's disease of bone.

    Science.gov (United States)

    Ellis, Harold

    2013-04-01

    Sir James Paget was one of the 'great' Victorians. Eminent as a surgeon, pathologist and teacher, his nobility of character and application to his work made him a leader in his profession in that age of great men.

  11. Beverage can stay-tabs: still a source for inadvertently ingested foreign bodies in children

    Energy Technology Data Exchange (ETDEWEB)

    Donnelly, Lane F. [Cincinnati Children' s Hospital Medical Center, Department of Radiology, MLC 5031, Cincinnati, OH (United States); University of Cincinnati, College of Medicine, Departments of Radiology and Pediatrics, Cincinnati, OH (United States)

    2010-09-15

    In the 1970s in part to avoid inadvertent ingestion, the beverage-can industry changed can construction from pull-tabs to the stay-tabs (remain attached to can after opening) used today. Our purpose is to identify the number of inadvertent ingestions of beverage-can stay-tabs by children recognized at our institution. The medical information system of a children's hospital was searched with key terms to identify cases in which a witnessed or self-reported inadvertent ingestion of a beverage-can stay-tab resulted in a radiograph to rule out presence of a foreign body. Demographics, identification of stay-tab on radiographs, associated abnormalities, and patient management were reviewed. Nineteen cases of stay-tab ingestion were identified over 16 years. Mean age of ingesters was 8.5 years with the majority being teenagers and 15 (79%) >5 years of age. The stay-tab could be seen radiographically only in 4 (21%) cases - all with the stay-tab identified in the stomach. The identification of 19 children who inadvertently ingested beverage-can stay-tabs at a single children's hospital suggests that such ingestions still occur. Radiologists should be aware that stay-tabs are radiographically visible in the minority (21%) of cases. (orig.)

  12. Beverage can stay-tabs: still a source for inadvertently ingested foreign bodies in children

    International Nuclear Information System (INIS)

    Donnelly, Lane F.

    2010-01-01

    In the 1970s in part to avoid inadvertent ingestion, the beverage-can industry changed can construction from pull-tabs to the stay-tabs (remain attached to can after opening) used today. Our purpose is to identify the number of inadvertent ingestions of beverage-can stay-tabs by children recognized at our institution. The medical information system of a children's hospital was searched with key terms to identify cases in which a witnessed or self-reported inadvertent ingestion of a beverage-can stay-tab resulted in a radiograph to rule out presence of a foreign body. Demographics, identification of stay-tab on radiographs, associated abnormalities, and patient management were reviewed. Nineteen cases of stay-tab ingestion were identified over 16 years. Mean age of ingesters was 8.5 years with the majority being teenagers and 15 (79%) >5 years of age. The stay-tab could be seen radiographically only in 4 (21%) cases - all with the stay-tab identified in the stomach. The identification of 19 children who inadvertently ingested beverage-can stay-tabs at a single children's hospital suggests that such ingestions still occur. Radiologists should be aware that stay-tabs are radiographically visible in the minority (21%) of cases. (orig.)

  13. PredMP: A Web Resource for Computationally Predicted Membrane Proteins via Deep Learning

    KAUST Repository

    Wang, Sheng; Fei, Shiyang; Zongan, Wang; Li, Yu; Zhao, Feng; Gao, Xin

    2018-01-01

    structures in Protein Data Bank (PDB). To elucidate the MP structures computationally, we developed a novel web resource, denoted as PredMP (http://52.87.130.56:3001/#/proteinindex), that delivers one-dimensional (1D) annotation of the membrane topology

  14. A Possible Source For Sir Thomas More’s ‘Mountainish Inhumanity’

    NARCIS (Netherlands)

    Steenbergh, Kristine

    2017-01-01

    Shakespeare’s authorship of a scene in Sir Thomas More has been established as highly probable on the basis of an analysis of the handwriting, vocabulary, and collocations stylistics. His addition to the play was long believed to have been written soon after publication of the original play, in

  15. Fungal lectin MpL enables entry of protein drugs into cancer cells and their subcellular targeting.

    Science.gov (United States)

    Å Urga, Simon; Nanut, Milica Perišić; Kos, Janko; Sabotič, Jerica

    2017-04-18

    Lectins have been recognized as promising carrier molecules for targeted drug delivery. They specifically bind carbohydrate moieties on cell membranes and trigger cell internalization. Fungal lectin MpL (Macrolepiota procera lectin) does not provoke cancer cell cytotoxicity but is able to bind aminopeptidase N (CD13) and integrin α3β1, two glycoproteins that are overexpressed on the membrane of tumor cells. Upon binding, MpL is endocytosed in a clathrin-dependent manner and accumulates initially in the Golgi apparatus and, finally, in the lysosomes. For effective binding and internalization a functional binding site on the α-repeat is needed. To test the potential of MpL as a carrier for delivering protein drugs to cancer cells we constructed fusion proteins consisting of MpL and the cysteine peptidase inhibitors cystatin C and clitocypin. The fused proteins followed the same endocytic route as the unlinked MpL. Peptidase inhibitor-MpL fusions impaired both the intracellular degradation of extracellular matrix and the invasiveness of cancer cells. MpL is thus shown in vitro to be a lectin that can enable protein drugs to enter cancer cells, enhance their internalization and sort them to lysosomes and the Golgi apparatus.

  16. Sir Victor Horsley (1857-1916): pioneer of neurological surgery.

    Science.gov (United States)

    Tan, Tze-Ching; Black, Peter McL

    2002-03-01

    Immortalized in surgical history for the introduction of "antiseptic wax," Sir Victor Horsley played a pivotal role in shaping the face of standard neurosurgical practice. His contributions include the first laminectomy for spinal neoplasm, the first carotid ligation for cerebral aneurysm, the curved skin flap, the transcranial approach to the pituitary gland, intradural division of the trigeminal nerve root for trigeminal neuralgia, and surface marking of the cerebral cortex. A tireless scientist, he was a significant player in discovering the cure for myxedema, the eradication of rabies from England, and the invention of the Horsley-Clarke stereotactic frame. As a pathologist, Horsley performed research on bacteria and edema and founded the Journal of Pathology. Horsley's kindness, humility, and generous spirit endeared him to patients, colleagues, and students. Born to privilege, he was nonetheless dedicated to improving the lot of the common man and directed his efforts toward the suffrage of women, medical reform, and free health care for the working class. Knighted in 1902 for his many contributions to medicine, Sir Victor met an untimely death during World War I from heat stroke at the age of 59. An iconoclast of keen intellect, unlimited energy, and consummate skill, his life and work justify his epitaph as a "pioneer of neurological surgery."

  17. Sir William Osler's speech at Troy: a Trojan horse?

    Science.gov (United States)

    Moran, Michael E

    2012-01-01

    Troy, New York, is a city of 55,000 people in upstate New York located along the Hudson River. A city of surprisingly rich cultural heritage, it was the home of New York state's first hospital outside New York City. The 50th anniversary celebration of Troy's hospital brought William Osler to the city as the keynote speaker. This speech, delivered on November 28, 1900, is one of Sir William's less well known addresses. Osler began his comments with Sir Thomas More's Utopia and talked at length about the hospital, its obligations, the influences it has upon the community, and the role of physicians and surgeons. He broached one of his old saws, the salary of attending physicians and their needed role in hospital management. His words were published in the diamond jubilee's records, but the hospital did not outlive its prominent guest professor, and it closed its doors in 1914. Just like the great historical city of Troy, New York's own Troy was on the brink of decline, and its hospital would be the first fatality. Therefore, it is almost prescient that the words of Osler, taken into historical context juxtaposed against the socioeconomic forces at work, are akin to the Greek's offering of a wooden edifice to end the Trojan War.

  18. Discrete-event simulation of coordinated multi-point joint transmission in LTE-Advanced with constrained backhaul

    DEFF Research Database (Denmark)

    Artuso, Matteo; Christiansen, Henrik Lehrmann

    2014-01-01

    Inter-cell interference in LTE-Advanced can be mitigated using coordinated multi-point (CoMP) techniques with joint transmission of user data . However, this requires tight coordination of the eNodeBs, usin g the X2 interface. In this paper we use discrete-event simulation to evaluate the latency...... requirements for the X2 interface and investigate the consequences of a constrained ba ckhaul. Our simulation results show a gain of the system throug hput of up to 120% compared to the case without CoMP for low-latency backhaul. With X2 latencies above 5 ms CoMP is no longer a benefit to the network....

  19. MP3 - A Meteorology and Physical Properties Package for Titan Air-Sea Studies

    Science.gov (United States)

    Lorenz, R. D.; Stofan, E.; Lunine, J. I.; Zarnecki, J. C.; Harri, A.-M.; Karkoschka, E.; Newman, C. E.; Bierhaus, E. B.; Clark, B. C.; Yelland, M.; Leese, M. R.; Boldt, J.; Darlington, E.; Neish, C. D.; Sotzen, K.; Arvelo, J.; Rasbach, C.; Kretsch, W.; Strohbehn, K.; Grey, M.; Mann, J.; Zimmerman, H.; Reed, C.

    2012-10-01

    MP3 is a sensor suite for the proposed Titan Mare Explorer (TiME) Discovery mission to Ligeia Mare. MP3 will measure temperatures, and wind velocity, methane humidity, and pressure, as well as sea turbidity, dielectric properties, and depth via sonar.

  20. Sir John and Lady Rita Cornforth: a distinguished chemical partnership.

    Science.gov (United States)

    Purchase, Rupert; Hanson, James R

    2015-01-01

    This review describes the life of Sir John Cornforth AC CBE FRS, who was awarded the Nobel Prize for Chemistry in 1975. It covers his early life in Australia, his work in Oxford, the National Institute for Medical Research, the Milstead Laboratory of Chemical Enzymology and the University of Sussex, together with the contributions made by his wife, Lady Rita Cornforth.

  1. Stability and bifurcation analysis in a delayed SIR model

    International Nuclear Information System (INIS)

    Jiang Zhichao; Wei Junjie

    2008-01-01

    In this paper, a time-delayed SIR model with a nonlinear incidence rate is considered. The existence of Hopf bifurcations at the endemic equilibrium is established by analyzing the distribution of the characteristic values. A explicit algorithm for determining the direction of the Hopf bifurcation and the stability of the bifurcating periodic solutions are derived by using the normal form and the center manifold theory. Numerical simulations to support the analytical conclusions are carried out

  2. The use of multifrequency and polarimetric SIR-C/X-SAR data in geologic studies of Bir Safsaf, Egypt

    Science.gov (United States)

    Schaber, G.G.; McCauley, J.F.; Breed, C.S.

    1997-01-01

    Bir Safsaf, within the hyperarid 'core' of the Sahara in the Western Desert of Egypt, was recognized following the SIR-A and SIR-B missions in the 1980s as one of the key localities in northeast Africa, where penetration of dry sand by radar signals delineates previously unknown, sand-buried paleodrainage valleys ('radar-rivers') of middle Tertiary to Quaternary age. The Bir Safsaf area was targeted as a focal point for further research in sand penetration and geologic mapping using the multifrequency and polarimetric SIR-C/X-SAR sensors. Analysis of the SIR-C/X-SAR data from Bir Safsaf provides important new information on the roles of multiple SAR frequency and polarimetry in portraying specific types of geologic units, materials, and structures mostly hidden from view on the ground and on Landsat TM images by a relatively thin, but extensive blanket of blow sand. Basement rock units (granitoids and gneisses) and the fractures associated with them at Bir Safsaf are shown here for the first time to be clearly delineated using C- and L-band SAR images. The detectability of most geologic features is dependent primarily on radar frequency, as shown for wind erosion patterns in bedrock at X-band (3 cm wavelength), and for geologic units and sand and clay-filled fractures in weathered crystal-line basement rocks at C-band (6 cm) and L-band (24 cm). By contrast, Quaternary paleodrainage channels are detectable at all three radar frequencies owing, among other things, to an usually thin cover of blow sand. The SIR-C/X-SAR data investigated to date enable us to make specific recommendations about the utility of certain radar sensor configurations for geologic and paleoenvironmental reconnaissance in desert regions.Analysis of the shuttle imaging radar-C/X-synthetic aperture radar (SIR-C/X-SAR) data from Bir Safsaf provides important new information on the roles of multiple SAR frequency and polarimetry in portraying specific types of geologic units, materials, and

  3. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

    DEFF Research Database (Denmark)

    Lombard, David B; Alt, Frederick W; Cheng, Hwei-Ling

    2007-01-01

    Homologs of the Saccharomyces cerevisiae Sir2 protein, sirtuins, promote longevity in many organisms. Studies of the sirtuin SIRT3 have so far been limited to cell culture systems. Here, we investigate the localization and function of SIRT3 in vivo. We show that endogenous mouse SIRT3 is a solubl...

  4. Characterization of Rift Valley fever virus MP-12 strain encoding NSs of Punta Toro virus or sandfly fever Sicilian virus.

    Science.gov (United States)

    Lihoradova, Olga A; Indran, Sabarish V; Kalveram, Birte; Lokugamage, Nandadeva; Head, Jennifer A; Gong, Bin; Tigabu, Bersabeh; Juelich, Terry L; Freiberg, Alexander N; Ikegami, Tetsuro

    2013-01-01

    Rift Valley fever virus (RVFV; genus Phlebovirus, family Bunyaviridae) is a mosquito-borne zoonotic pathogen which can cause hemorrhagic fever, neurological disorders or blindness in humans, and a high rate of abortion in ruminants. MP-12 strain, a live-attenuated candidate vaccine, is attenuated in the M- and L-segments, but the S-segment retains the virulent phenotype. MP-12 was manufactured as an Investigational New Drug vaccine by using MRC-5 cells and encodes a functional NSs gene, the major virulence factor of RVFV which 1) induces a shutoff of the host transcription, 2) inhibits interferon (IFN)-β promoter activation, and 3) promotes the degradation of dsRNA-dependent protein kinase (PKR). MP-12 lacks a marker for differentiation of infected from vaccinated animals (DIVA). Although MP-12 lacking NSs works for DIVA, it does not replicate efficiently in type-I IFN-competent MRC-5 cells, while the use of type-I IFN-incompetent cells may negatively affect its genetic stability. To generate modified MP-12 vaccine candidates encoding a DIVA marker, while still replicating efficiently in MRC-5 cells, we generated recombinant MP-12 encoding Punta Toro virus Adames strain NSs (rMP12-PTNSs) or Sandfly fever Sicilian virus NSs (rMP12-SFSNSs) in place of MP-12 NSs. We have demonstrated that those recombinant MP-12 viruses inhibit IFN-β mRNA synthesis, yet do not promote the degradation of PKR. The rMP12-PTNSs, but not rMP12-SFSNSs, replicated more efficiently than recombinant MP-12 lacking NSs in MRC-5 cells. Mice vaccinated with rMP12-PTNSs or rMP12-SFSNSs induced neutralizing antibodies at a level equivalent to those vaccinated with MP-12, and were efficiently protected from wild-type RVFV challenge. The rMP12-PTNSs and rMP12-SFSNSs did not induce antibodies cross-reactive to anti-RVFV NSs antibody and are therefore applicable to DIVA. Thus, rMP12-PTNSs is highly efficacious, replicates efficiently in MRC-5 cells, and encodes a DIVA marker, all of which are

  5. Implementation of MP3 player for music therapy on hypertension.

    Science.gov (United States)

    Yu, J Y; Huang, D F; Li, Y; Zhang, Y T

    2009-01-01

    Hypertension is a common clinical disease and a major risk to human health. Many clinical findings indicate that certain types of music can reduce blood pressure (BP), and music therapy is considered as an important part of anti-hypertension treatment. We integrate our former related research achievement into the new MP3 player, which can also detect the current BP value with a cuffless measurement method. According to the current BP value, the MP3 player selects certain types of music for playing in order to alleviate the hypertension of patients.

  6. Sir Rudolf Peierls Selected private and scientific correspondence

    CERN Document Server

    Lee, Sabine

    2007-01-01

    This edition of the private and scientific correspondence of Sir Rudolf Peierls gives a unique insight into the life and work of one of the greatest theoretical physicists of the 20th century. Rudolf Peierls' scientific work contributed to the early developments in quantum mechanics, and he is well known and much appreciated for his contributions to various disciplines, including solid state physics, nuclear physics, and particle physics. As an enthusiastic and devoted teacher, he passed on his knowledge and understanding and inspired the work of collaborators and students alike. As an effecti

  7. Numeric experiments on the Cray X-MP/48

    International Nuclear Information System (INIS)

    Chauvet, Y.; David, J.; Meurant, G.

    1985-06-01

    In this paper, evaluation tests for the CRAY X-MP/48 are presented. We use parallel algorithms for solving the transport equation with Monte-Carlo and the conjugate gradient method for solving linear systems [fr

  8. PredMP: A Web Resource for Computationally Predicted Membrane Proteins via Deep Learning

    KAUST Repository

    Wang, Sheng

    2018-02-06

    Experimental determination of membrane protein (MP) structures is challenging as they are often too large for nuclear magnetic resonance (NMR) experiments and difficult to crystallize. Currently there are only about 510 non-redundant MPs with solved structures in Protein Data Bank (PDB). To elucidate the MP structures computationally, we developed a novel web resource, denoted as PredMP (http://52.87.130.56:3001/#/proteinindex), that delivers one-dimensional (1D) annotation of the membrane topology and secondary structure, two-dimensional (2D) prediction of the contact/distance map, together with three-dimensional (3D) modeling of the MP structure in the lipid bilayer, for each MP target from a given model organism. The precision of the computationally constructed MP structures is leveraged by state-of-the-art deep learning methods as well as cutting-edge modeling strategies. In particular, (i) we annotate 1D property via DeepCNF (Deep Convolutional Neural Fields) that not only models complex sequence-structure relationship but also interdependency between adjacent property labels; (ii) we predict 2D contact/distance map through Deep Transfer Learning which learns the patterns as well as the complex relationship between contacts/distances and protein features from non-membrane proteins; and (iii) we model 3D structure by feeding its predicted contacts and secondary structure to the Crystallography & NMR System (CNS) suite combined with a membrane burial potential that is residue-specific and depth-dependent. PredMP currently contains more than 2,200 multi-pass transmembrane proteins (length<700 residues) from Human. These transmembrane proteins are classified according to IUPHAR/BPS Guide, which provides a hierarchical organization of receptors, channels, transporters, enzymes and other drug targets according to their molecular relationships and physiological functions. Among these MPs, we estimated that our approach could predict correct folds for 1

  9. MP3-e leiutajatele jäävad näpud / Patrick Jenkins

    Index Scriptorium Estoniae

    Jenkins, Patrick

    2005-01-01

    Tänu MP3-mängija iPod edukale müügile suurenes Apple Computeri I kvartali kasum 368% ning oli 295 miljonit dollarit. MP3 tehnoloogia leiutati Saksamaal peaaegu 20 aastat tagasi, kuid tookord ei saadud tehnoloogia rakendamiseks Euroopas tuge. Lisa: MPEG Layer 3 kodeerimine

  10. Application of Homotopy Perturbation and Variational Iteration Methods to SIR Epidemic Model

    DEFF Research Database (Denmark)

    Ghotbi, Abdoul R.; Barari, Amin; Omidvar, M.

    2011-01-01

    effective strategy against childhood diseases, the development of the framework that would predict the optimal vaccine coverage level needed to prevent the spread of diseases is crucial. The SIR model is a standard compartmental model that has been used to describe many epidemiological diseases...

  11. Sir Victor Horsley: pioneer craniopharyngioma surgeon.

    Science.gov (United States)

    Pascual, José M; Prieto, Ruth; Mazzarello, Paolo

    2015-07-01

    Sir Victor Horsley (1857-1916) is considered to be the pioneer of pituitary surgery. He is known to have performed the first surgical operation on the pituitary gland in 1889, and in 1906 he stated that he had operated on 10 patients with pituitary tumors. He did not publish the details of these procedures nor did he provide evidence of the pathology of the pituitary lesions operated on. Four of the patients underwent surgery at the National Hospital for Neurology and Neurosurgery (Queen Square, London), and the records of those cases were recently retrieved and analyzed by members of the hospital staff. The remaining cases corresponded to private operations whose records were presumably kept in Horsley's personal notebooks, most of which have been lost. In this paper, the authors have investigated the only scientific monograph providing a complete account of the pituitary surgeries that Horsley performed in his private practice, La Patologia Chirurgica dell'Ipofisi (Surgical Pathology of the Hypophysis), written in 1911 by Giovanni Verga, Italian assistant professor of anatomy at the University of Pavia. They have traced the life and work of this little-known physician who contributed to the preservation of Horsley's legacy in pituitary surgery. Within Verga's pituitary treatise, a full transcription of Horsley's notes is provided for 10 pituitary cases, including the patients' clinical symptoms, surgical techniques employed, intraoperative findings, and the outcome of surgery. The descriptions of the topographical and macroscopic features of two of the lesions correspond unmistakably to the features of craniopharyngiomas, one of the squamous-papillary type and one of the adamantinomatous type. The former lesion was found on necropsy after the patient's sudden death following a temporal osteoplastic craniectomy. Surgical removal of the lesion in the latter case, with the assumed nature of an adamantinomatous craniopharyngioma, was successful. According to the

  12. HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein

    International Nuclear Information System (INIS)

    Yu Qingsheng; Minoda, Yasumasa; Yoshida, Ryoko; Yoshida, Hideyuki; Iha, Hidekatsu; Kobayashi, Takashi; Yoshimura, Akihiko; Takaesu, Giichi

    2008-01-01

    Human T cell leukemia virus type 1 (HTLV-1) Tax is an oncoprotein that plays a crucial role in the proliferation and transformation of HTLV-1-infected T lymphocytes. It has recently been reported that Tax activates a MAPKKK family, TAK1. However, the molecular mechanism of Tax-mediated TAK1 activation is not well understood. In this report, we investigated the role of TAK1-binding protein 2 (TAB2) in Tax-mediated TAK1 activation. We found that TAB2 physically interacts with Tax and augments Tax-induced NF-κB activity. Tax and TAB2 cooperatively activate TAK1 when they are coexpressed. Furthermore, TAK1 activation by Tax requires TAB2 binding as well as ubiquitination of Tax. We also found that the overexpression of TRAF2, 5, or 6 strongly induces Tax ubiquitination. These results suggest that TAB2 may be critically involved in Tax-mediated activation of TAK1 and that NF-κB-activating TRAF family proteins are potential cellular E3 ubiquitin ligases toward Tax

  13. Performance modeling of hybrid MPI/OpenMP scientific applications on large-scale multicore supercomputers

    KAUST Repository

    Wu, Xingfu; Taylor, Valerie

    2013-01-01

    In this paper, we present a performance modeling framework based on memory bandwidth contention time and a parameterized communication model to predict the performance of OpenMP, MPI and hybrid applications with weak scaling on three large-scale multicore supercomputers: IBM POWER4, POWER5+ and BlueGene/P, and analyze the performance of these MPI, OpenMP and hybrid applications. We use STREAM memory benchmarks and Intel's MPI benchmarks to provide initial performance analysis and model validation of MPI and OpenMP applications on these multicore supercomputers because the measured sustained memory bandwidth can provide insight into the memory bandwidth that a system should sustain on scientific applications with the same amount of workload per core. In addition to using these benchmarks, we also use a weak-scaling hybrid MPI/OpenMP large-scale scientific application: Gyrokinetic Toroidal Code (GTC) in magnetic fusion to validate our performance model of the hybrid application on these multicore supercomputers. The validation results for our performance modeling method show less than 7.77% error rate in predicting the performance of hybrid MPI/OpenMP GTC on up to 512 cores on these multicore supercomputers. © 2013 Elsevier Inc.

  14. PCR melting profile (PCR MP - a new tool for differentiation of Candida albicans strains

    Directory of Open Access Journals (Sweden)

    Nowak Magdalena

    2009-11-01

    Full Text Available Abstract Background We have previously reported the use of PCR Melting Profile (PCR MP technique based on using low denaturation temperatures during ligation mediated PCR (LM PCR for bacterial strain differentiation. The aim of the current study was to evaluate this method for intra-species differentiation of Candida albicans strains. Methods In total 123 Candida albicans strains (including 7 reference, 11 clinical unrelated, and 105 isolates from patients of two hospitals in Poland were examined using three genotyping methods: PCR MP, macrorestriction analysis of the chromosomal DNA by pulsed-field gel electrophoresis (REA-PFGE and RAPD techniques. Results The genotyping results of the PCR MP were compared with results from REA-PFGE and RAPD techniques giving 27, 26 and 25 unique types, respectively. The results showed that the PCR MP technique has at least the same discriminatory power as REA-PFGE and RAPD. Conclusion Data presented here show for the first time the evaluation of PCR MP technique for candidial strains differentiation and we propose that this can be used as a relatively simple and cheap technique for epidemiological studies in short period of time in hospital.

  15. Performance modeling of hybrid MPI/OpenMP scientific applications on large-scale multicore supercomputers

    KAUST Repository

    Wu, Xingfu

    2013-12-01

    In this paper, we present a performance modeling framework based on memory bandwidth contention time and a parameterized communication model to predict the performance of OpenMP, MPI and hybrid applications with weak scaling on three large-scale multicore supercomputers: IBM POWER4, POWER5+ and BlueGene/P, and analyze the performance of these MPI, OpenMP and hybrid applications. We use STREAM memory benchmarks and Intel\\'s MPI benchmarks to provide initial performance analysis and model validation of MPI and OpenMP applications on these multicore supercomputers because the measured sustained memory bandwidth can provide insight into the memory bandwidth that a system should sustain on scientific applications with the same amount of workload per core. In addition to using these benchmarks, we also use a weak-scaling hybrid MPI/OpenMP large-scale scientific application: Gyrokinetic Toroidal Code (GTC) in magnetic fusion to validate our performance model of the hybrid application on these multicore supercomputers. The validation results for our performance modeling method show less than 7.77% error rate in predicting the performance of hybrid MPI/OpenMP GTC on up to 512 cores on these multicore supercomputers. © 2013 Elsevier Inc.

  16. Benchmarking Hydrogen and Carbon NMR Chemical Shifts at HF, DFT, and MP2 Levels.

    Science.gov (United States)

    Flaig, Denis; Maurer, Marina; Hanni, Matti; Braunger, Katharina; Kick, Leonhard; Thubauville, Matthias; Ochsenfeld, Christian

    2014-02-11

    An extensive study of error distributions for calculating hydrogen and carbon NMR chemical shifts at Hartree-Fock (HF), density functional theory (DFT), and Møller-Plesset second-order perturbation theory (MP2) levels is presented. Our investigation employs accurate CCSD(T)/cc-pVQZ calculations for providing reference data for 48 hydrogen and 40 carbon nuclei within an extended set of chemical compounds covering a broad range of the NMR scale with high relevance to chemical applications, especially in organic chemistry. Besides the approximations of HF, a variety of DFT functionals, and conventional MP2, we also present results with respect to a spin component-scaled MP2 (GIAO-SCS-MP2) approach. For each method, the accuracy is analyzed in detail for various basis sets, allowing identification of efficient combinations of method and basis set approximations.

  17. Statistical Characterization of MP3 Encoders for Steganalysis: ’CHAMP3’

    Science.gov (United States)

    2004-04-27

    compression exceeds those of typical stegano- graphic tools (e. g., LSB image embedding), the availability of commented source codes for MP3 encoders...developed by testing the approach on known and unknown reference data. 15. SUBJECT TERMS EOARD, Steganography , Digital Watermarking...Pages kbps Kilobits per Second LGPL Lesser General Public License LSB Least Significant Bit MB Megabyte MDCT Modified Discrete Cosine Transformation MP3

  18. NMR, MP2 and DFT Study of Thiophenoxyketenimines (o-ThioSchiff bases)

    DEFF Research Database (Denmark)

    Saeed, Bahjat Ali; Elias, Rita Sabah; Kamounah, Fadhil S.

    2018-01-01

    Five new thiophenoxyketinimines have been synthesized. 1 H and 13 C NMR spectra as well as deuterium isotope effects on 13 C chemical shifts are determined, and spectra are assigned. DFT and MP2 calculations of both structures, chemical shifts, and isotope effects on chemical shifts are done...... that calculations at the MP2 level are best to obtain correct "C═S" chemical shifts....

  19. Improving Security at Work with Software that Uses OpenMP

    Directory of Open Access Journals (Sweden)

    P. S. Polishuk

    2010-03-01

    Full Text Available A model of the offender and the list of major types of threats, the conditions for the realization of which are created by using the software that uses OpenMP is considered. A method for verification of software using OpenMP for the presence of vulnerabilities associated with multi-threaded execution is offered. We give basic algorithms and the system architecture that implements the proposed method. The results of testing the method on various programs, including those containing malicious code, as well as assessment of the possibilities of applying the method in different computing environments are given.

  20. Performance of a Code Migration for the Simulation of Supersonic Ejector Flow to SMP, MIC, and GPU Using OpenMP, OpenMP+LEO, and OpenACC Directives

    Directory of Open Access Journals (Sweden)

    C. Couder-Castañeda

    2015-01-01

    Full Text Available A serial source code for simulating a supersonic ejector flow is accelerated using parallelization based on OpenMP and OpenACC directives. The purpose is to reduce the development costs and to simplify the maintenance of the application due to the complexity of the FORTRAN source code. This research follows well-proven strategies in order to obtain the best performance in both OpenMP and OpenACC. OpenMP has become the programming standard for scientific multicore software and OpenACC is one true alternative for graphics accelerators without the need of programming low level kernels. The strategies using OpenMP are oriented towards reducing the creation of parallel regions, tasks creation to handle boundary conditions, and a nested control of the loop time for the programming in offload mode specifically for the Xeon Phi. In OpenACC, the strategy focuses on maintaining the data regions among the executions of the kernels. Experiments for performance and validation are conducted here on a 12-core Xeon CPU, Xeon Phi 5110p, and Tesla C2070, obtaining the best performance from the latter. The Tesla C2070 presented an acceleration factor of 9.86X, 1.6X, and 4.5X compared against the serial version on CPU, 12-core Xeon CPU, and Xeon Phi, respectively.

  1. A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability.

    Directory of Open Access Journals (Sweden)

    Tânia Reis

    2010-11-01

    Full Text Available Obesity has a strong genetic component, but few of the genes that predispose to obesity are known. Genetic screens in invertebrates have the potential to identify genes and pathways that regulate the levels of stored fat, many of which are likely to be conserved in humans. To facilitate such screens, we have developed a simple buoyancy-based screening method for identifying mutant Drosophila larvae with increased levels of stored fat. Using this approach, we have identified 66 genes that when mutated increase organismal fat levels. Among these was a sirtuin family member, Sir2. Sirtuins regulate the storage and metabolism of carbohydrates and lipids by deacetylating key regulatory proteins. However, since mammalian sirtuins function in many tissues in different ways, it has been difficult to define their role in energy homeostasis accurately under normal feeding conditions. We show that knockdown of Sir2 in the larval fat body results in increased fat levels. Moreover, using genetic mosaics, we demonstrate that Sir2 restricts fat accumulation in individual cells of the fat body in a cell-autonomous manner. Consistent with this function, changes in the expression of metabolic enzymes in Sir2 mutants point to a shift away from catabolism. Surprisingly, although Sir2 is typically upregulated under conditions of starvation, Sir2 mutant larvae survive better than wild type under conditions of amino-acid starvation as long as sugars are provided. Our findings point to a Sir2-mediated pathway that activates a catabolic response to amino-acid starvation irrespective of the sugar content of the diet.

  2. Mineral distribution in rice: Measurement by Microwave Plasma Atomic Emission Spectroscopy (MP-AES)

    International Nuclear Information System (INIS)

    Ramos, Nerissa C.; Ramos, R.G.A.; Quirit, L.L.; Arcilla, C.A.

    2015-01-01

    Microwave Plasma Atomic Emission Spectroscopy (MP-AES) is a new technology with comparable performance and sensitivity to Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). Both instrument use plasma as the energy source that produces atomic and ionic emission lines. However, MP-AES uses nitrogen as the plasma gas instead of argon which is an additional expense for ICP-OES. Thus, MP-AES is more economical. This study quantified six essential minerals (Se, Zn, Fe, Cu, Mn and K) in rice using MP-AES. Hot plate digestion was used for sample extraction and the detection limit for each instrument was compared with respect to the requirement for routine analysis in rice. Black, red and non-pigmented rice samples were polished in various intervals to determine the concentration loss of minerals. The polishing time corresponds to the structure of the rice grains such as outer bran layer (0 to 15), inner bran layer (15 to 30), outer endosperm layer (30 to 45), and middle endosperm layer (45 to 60). Results of MP-AES analysis showed that black rice had all essential materials (except K) in high concentration at the outer bran layer. The red and non-pigmented rice samples on the other hand, contained high levels of Se, Zn, Fe, and Mn in the whole bran portion. After 25 seconds, the mineral concentrations remained constant. The concentration of Cu however, gave consistent value in all polishing intervals, hence Cu might be located in the inner endosperm layer. Results also showed that K was uniformly distributed in all samples where 5% loss was consistently observed for every polishing interval. Therefore, the concentration of K was also affected by polishing time. Thus, the new MP-AES technology with comparable performance to ICP-OES is a promising tool for routine analysis in rice. (author)

  3. Effective Vectorization with OpenMP 4.5

    Energy Technology Data Exchange (ETDEWEB)

    Huber, Joseph N. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hernandez, Oscar R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lopez, Matthew Graham [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-03-01

    This paper describes how the Single Instruction Multiple Data (SIMD) model and its extensions in OpenMP work, and how these are implemented in different compilers. Modern processors are highly parallel computational machines which often include multiple processors capable of executing several instructions in parallel. Understanding SIMD and executing instructions in parallel allows the processor to achieve higher performance without increasing the power required to run it. SIMD instructions can significantly reduce the runtime of code by executing a single operation on large groups of data. The SIMD model is so integral to the processor s potential performance that, if SIMD is not utilized, less than half of the processor is ever actually used. Unfortunately, using SIMD instructions is a challenge in higher level languages because most programming languages do not have a way to describe them. Most compilers are capable of vectorizing code by using the SIMD instructions, but there are many code features important for SIMD vectorization that the compiler cannot determine at compile time. OpenMP attempts to solve this by extending the C++/C and Fortran programming languages with compiler directives that express SIMD parallelism. OpenMP is used to pass hints to the compiler about the code to be executed in SIMD. This is a key resource for making optimized code, but it does not change whether or not the code can use SIMD operations. However, in many cases critical functions are limited by a poor understanding of how SIMD instructions are actually implemented, as SIMD can be implemented through vector instructions or simultaneous multi-threading (SMT). We have found that it is often the case that code cannot be vectorized, or is vectorized poorly, because the programmer does not have sufficient knowledge of how SIMD instructions work.

  4. May thrombopoietin be a useful marker of sepsis severity assessment in patients with SIRS entering the emergency department?

    Science.gov (United States)

    Segre, Elisabetta; Pigozzi, Luca; Lison, Davide; Pivetta, Emanuele; Bosco, Ornella; Vizio, Barbara; Suppo, Umberto; Turvani, Fabrizio; Morello, Fulvio; Battista, Stefania; Moiraghi, Corrado; Montrucchio, Giuseppe; Lupia, Enrico

    2014-10-01

    Thrombopoietin (TPO), a growth factor primarily involved in regulating thrombopoiesis, has been recently implicated in the pathogenesis of sepsis. TPO levels are, indeed, greatly increased in patients with sepsis compared to control subjects, and correlate with sepsis severity. The aim of this study was to evaluate TPO as predictive biomarker of sepsis and of sepsis severity in patients entering the emergency department (ED) with systemic inflammatory response syndrome (SIRS). This was a prospective observational study. Ours is a sub-study of the 'Need-speed trial', a multi-center observational study involving six Italian centers affiliated to the GREAT Italian Network. TPO was measured by ELISA. We enrolled 13 patients with SIRS (6 with acute pancreatitis, 3 with acute heart failure, 1 with pulmonary embolism, and 3 with allergic reactions), and 40 patients with sepsis, eight of whom had severe sepsis and three septic shock. TPO was significantly higher in patients with sepsis than with SIRS. In addition, TPO was higher in patients with severe sepsis than with sepsis, and in patients with septic shock than with severe sepsis, although these differences did not reach the statistical significance. Our preliminary results suggest that TPO may have the potential to be considered a promising early biomarker for both the diagnosis of sepsis and the assessment of sepsis severity in patients with SIRS entering the ED.

  5. Redox poly[Ni(saldMp)] modified activated carbon electrode in electrochemical supercapacitors

    Energy Technology Data Exchange (ETDEWEB)

    Gao Fei [Department of Physical Chemistry, University of Science and Technology Beijing, 30 Xueyuan Road, Haidian District, Beijing 100083 (China); Li Jianling, E-mail: lijianling@ustb.edu.c [Department of Physical Chemistry, University of Science and Technology Beijing, 30 Xueyuan Road, Haidian District, Beijing 100083 (China); Zhang Yakun; Wang Xindong [Department of Physical Chemistry, University of Science and Technology Beijing, 30 Xueyuan Road, Haidian District, Beijing 100083 (China); Kang Feiyu [Department of Material Science and Engineering, Tsinghua University, Beijing 100083 (China)

    2010-08-01

    The complex (2,2-dimethyl-1,3-propanediaminebis(salicylideneaminato))-nickel(II), [Ni(saldMp)], was oxidatively electropolymerized on activated carbon (AC) electrode in acetonitrile solution. The poly[Ni(saldMp)] presented an incomplete coated film on the surface of carbon particles of AC electrode by field emission scanning electron microscopy. The electrochemical behaviors of poly[Ni(saldMp)] modified activated carbon (PAC) electrode were evaluated in different potential ranges by cyclic voltammetry. Counterions and solvent swelling mainly occurred up to 0.6 V for PAC electrode by the comparison of D{sup 1/2}C values calculated from chronoamperometry experiments. Both the Ohmic resistance and Faraday resistance of PAC electrode gradually approached to those of AC electrode when its potential was ranging from 1.2 V to 0.0 V. Galvanostatic charge/discharge experiments indicated that both the specific capacitance and energy density were effectively improved by the reversible redox reaction of poly[Ni(saldMp)] film under the high current density up to 10 mA cm{sup -2} for AC electrode. The specific capacitance of PAC electrode decreased during the first 50 cycles but thereafter it remained constant for the next 200 cycles. This study showed the redox polymer may be an attractive material in supercapacitors.

  6. Benchmarking MILC code with OpenMP and MPI

    International Nuclear Information System (INIS)

    Gottlieb, Steven; Tamhankar, Sonali

    2001-01-01

    A trend in high performance computers that is becoming increasingly popular is the use of symmetric multi-processing (SMP) rather than the older paradigm of MPP. MPI codes that ran and scaled well on MPP machines can often be run on an SMP machine using the vendor's version of MPI. However, this approach may not make optimal use of the (expensive) SMP hardware. More significantly, there are machines like Blue Horizon, an IBM SP with 8-way SMP nodes at the San Diego Supercomputer Center that can only support 4 MPI processes per node (with the current switch). On such a machine it is imperative to be able to use OpenMP parallelism on the node, and MPI between nodes. We describe the challenges of converting MILC MPI code to using a second level of OpenMP parallelism, and benchmarks on IBM and Sun computers

  7. Climate classification for the simulation of thermally activated building systems (TABS)

    DEFF Research Database (Denmark)

    Behrendt, Benjamin; Christensen, Jørgen Erik

    2013-01-01

    alternative (sustainable) energy sources that would otherwise be insufficient. The design of TABS is however challenging and most often requires a complete simulation of the building. The standard ISO 11855-4 (2011) suggests a simplified sizing method for TABS. The results however omit condensation risk...... entirely. The proposed climate classification should fill this gap by providing the missing data in a simple manner....

  8. Cu2+ triggers reversible aggregation of a disordered His-rich dehydrin MpDhn12 from Musa paradisiaca.

    Science.gov (United States)

    Mu, Peiqiang; Feng, Dongru; Su, Jianbin; Zhang, Yang; Dai, Jinran; Jin, Honglei; Liu, Bing; He, Yanming; Qi, Kangbiao; Wang, Hongbin; Wang, Jinfa

    2011-11-01

    Copper is an essential nutrient, but it is toxic in excess. Here, we cloned and characterized a His-rich low molecular weight dehydrin from Musa paradisiaca, MpDhn12. Analysis by circular dichroism (CD) spectra and a thermal stability assay showed that MpDhn12 is an intrinsically disordered protein, and immobilized-metal affinity chromatography (IMAC) analysis revealed that MpDhn12 can bind Cu(2+) both in vitro and in vivo. Interestingly, MpDhn12 aggregated under excess Cu(2+) conditions, and the aggregation was reversible and impaired by histidine modification with diethylpyrocarbonate (DEPC), while the disordered structure of another dehydrin ERD14 (as a control) was not changed. Furthermore, MpDhn12 could complement the copper-sensitive phenotype of yeast mutant Δsod1. These results together suggested that MpDhn12 may take part in buffering copper levels through chelation and formation of aggregates in excess Cu(2+) conditions. To the best of our knowledge, it is the first report that a dehydrin interchanged between disordered and aggregated state triggered by copper.

  9. Center for Programming Models for Scalable Parallel Computing - Towards Enhancing OpenMP for Manycore and Heterogeneous Nodes

    Energy Technology Data Exchange (ETDEWEB)

    Barbara Chapman

    2012-02-01

    OpenMP was not well recognized at the beginning of the project, around year 2003, because of its limited use in DoE production applications and the inmature hardware support for an efficient implementation. Yet in the recent years, it has been graduately adopted both in HPC applications, mostly in the form of MPI+OpenMP hybrid code, and in mid-scale desktop applications for scientific and experimental studies. We have observed this trend and worked deligiently to improve our OpenMP compiler and runtimes, as well as to work with the OpenMP standard organization to make sure OpenMP are evolved in the direction close to DoE missions. In the Center for Programming Models for Scalable Parallel Computing project, the HPCTools team at the University of Houston (UH), directed by Dr. Barbara Chapman, has been working with project partners, external collaborators and hardware vendors to increase the scalability and applicability of OpenMP for multi-core (and future manycore) platforms and for distributed memory systems by exploring different programming models, language extensions, compiler optimizations, as well as runtime library support.

  10. Risk analysis of inter-species reassortment through a Rift Valley fever phlebovirus MP-12 vaccine strain.

    Directory of Open Access Journals (Sweden)

    Hoai J Ly

    Full Text Available Rift Valley fever (RVF is a mosquito-borne zoonotic disease endemic to Africa and the Arabian Peninsula. The causative agent, Rift Valley fever phlebovirus (RVFV, belongs to the genus Phlebovirus in the family Phenuiviridae and causes high rates of abortions in ruminants, and hemorrhagic fever, encephalitis, or blindness in humans. Viral maintenance by mosquito vectors has led to sporadic RVF outbreaks in ruminants and humans in endemic countries, and effective vaccination of animals and humans may minimize the impact of this disease. A live-attenuated MP-12 vaccine strain is one of the best characterized RVFV strains, and was conditionally approved as a veterinary vaccine in the U.S. Live-attenuated RVF vaccines including MP-12 strain may form reassortant strains with other bunyavirus species. This study thus aimed to characterize the occurrence of genetic reassortment between the MP-12 strain and bunyavirus species closely related to RVFV. The Arumowot virus (AMTV and Gouleako goukovirus (GOLV, are transmitted by mosquitoes in Africa. The results of this study showed that GOLV does not form detectable reassortant strains with the MP-12 strain in co-infected C6/36 cells. The AMTV also did not form any reassortant strains with MP-12 strain in co-infected C6/36 cells, due to the incompatibility among N, L, and Gn/Gc proteins. A lack of reassortant formation could be due to a functional incompatibility of N and L proteins derived from heterologous species, and due to a lack of packaging via heterologous Gn/Gc proteins. The MP-12 strain did, however, randomly exchange L-, M-, and S-segments with a genetic variant strain, rMP12-GM50, in culture cells. The MP-12 strain is thus unlikely to form any reassortant strains with AMTV or GOLV in nature.

  11. Search for the lepton-flavour violating decay $D^0 \\to e^\\pm\\mu^\\mp$

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Anderson, Jonathan; Andreassi, Guido; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; d'Argent, Philippe; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Bel, Lennaert; Bellee, Violaine; Belloli, Nicoletta; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bertolin, Alessandro; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bifani, Simone; Billoir, Pierre; Bird, Thomas; Birnkraut, Alex; Bizzeti, Andrea; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Braun, Svende; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Brook, Nicholas; Buchanan, Emma; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Campana, Pierluigi; Campora Perez, Daniel; Capriotti, Lorenzo; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carniti, Paolo; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cavallero, Giovanni; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cogoni, Violetta; Cojocariu, Lucian; Collazuol, Gianmaria; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Crocombe, Andrew; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dall'Occo, Elena; Dalseno, Jeremy; David, Pieter; Davis, Adam; De Aguiar Francisco, Oscar; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Demmer, Moritz; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Dey, Biplab; Di Canto, Angelo; Di Ruscio, Francesco; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dreimanis, Karlis; Dufour, Laurent; Dujany, Giulio; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farley, Nathanael; Farry, Stephen; Fay, Robert; Ferguson, Dianne; Fernandez Albor, Victor; Ferrari, Fabio; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fleuret, Frederic; Fohl, Klaus; Fol, Philip; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; García Pardiñas, Julián; Garra Tico, Jordi; Garrido, Lluis; Gascon, David; Gaspar, Clara; Gauld, Rhorry; Gavardi, Laura; Gazzoni, Giulio; Gerick, David; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianì, Sebastiana; Gibson, Valerie; Girard, Olivier Göran; Giubega, Lavinia-Helena; Gligorov, V.V.; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graverini, Elena; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadavizadeh, Thomas; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Henry, Louis; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Humair, Thibaud; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jawahery, Abolhassan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Karodia, Sarah; Kecke, Matthieu; Kelsey, Matthew; Kenyon, Ian; Kenzie, Matthew; Ketel, Tjeerd; Khairullin, Egor; Khanji, Basem; Khurewathanakul, Chitsanu; Klaver, Suzanne; Klimaszewski, Konrad; Kochebina, Olga; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Kozeiha, Mohamad; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krokovny, Pavel; Kruse, Florian; Krzemien, Wojciech; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kuonen, Axel Kevin; Kurek, Krzysztof; Kvaratskheliya, Tengiz; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Lemos Cid, Edgar; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Liu, Xuesong; Loh, David; Longstaff, Iain; Lopes, Jose; Lucchesi, Donatella; Lucio Martinez, Miriam; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Lusiani, Alberto; Machefert, Frederic; Maciuc, Florin; Maev, Oleg; Maguire, Kevin; Malde, Sneha; Malinin, Alexander; Manca, Giulia; Mancinelli, Giampiero; Manning, Peter Michael; Mapelli, Alessandro; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Marks, Jörg; Martellotti, Giuseppe; Martin, Morgan; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massacrier, Laure Marie; Massafferri, André; Matev, Rosen; Mathad, Abhijit; Mathe, Zoltan; Matteuzzi, Clara; Mauri, Andrea; Maurin, Brice; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; Meadows, Brian; Meier, Frank; Meissner, Marco; Melnychuk, Dmytro; Merk, Marcel; Michielin, Emanuele; Milanes, Diego Alejandro; Minard, Marie-Noelle; Mitzel, Dominik Stefan; Molina Rodriguez, Josue; Monroy, Ignacio Alberto; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Müller, Dominik; Müller, Janine; Müller, Katharina; Müller, Vanessa; Mussini, Manuel; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nandi, Anita; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Osorio Rodrigues, Bruno; Otalora Goicochea, Juan Martin; Otto, Adam; Owen, Patrick; Oyanguren, Maria Aranzazu; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Pappenheimer, Cheryl; Parker, William; Parkes, Christopher; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Perret, Pascal; Pescatore, Luca; Petridis, Konstantinos; Petrolini, Alessandro; Petruzzo, Marco; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Pistone, Alessandro; Piucci, Alessio; Playfer, Stephen; Plo Casasus, Maximo; Poikela, Tuomas; Polci, Francesco; Poluektov, Anton; Polyakov, Ivan; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Price, Eugenia; Price, Joseph David; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Quagliani, Renato; Rachwal, Bartolomiej; Rademacker, Jonas; Rama, Matteo; Ramos Pernas, Miguel; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Redi, Federico; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vincente; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Lopez, Jairo Alexis; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Ronayne, John William; Rotondo, Marcello; Ruf, Thomas; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santimaria, Marco; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmelzer, Timon; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schubiger, Maxime; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Siddi, Benedetto Gianluca; Silva Coutinho, Rafael; Silva de Oliveira, Luiz Gustavo; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skwarnicki, Tomasz; Smith, Edmund; Smith, Eluned; Smith, Iwan Thomas; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Stefkova, Slavorima; Steinkamp, Olaf; Stenyakin, Oleg; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szumlak, Tomasz; T'Jampens, Stephane; Tayduganov, Andrey; Tekampe, Tobias; Teklishyn, Maksym; Tellarini, Giulia; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Todd, Jacob; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Trabelsi, Karim; Tran, Minh Tâm; Tresch, Marco; Trisovic, Ana; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Volkov, Vladimir; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Weiden, Andreas; Whitehead, Mark; Wilkinson, Guy; Wilkinson, Michael; Williams, Mark Richard James; Williams, Matthew; Williams, Mike; Williams, Timothy; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wraight, Kenneth; Wright, Simon; Wyllie, Kenneth; Xie, Yuehong; Xu, Zhirui; Yang, Zhenwei; Yu, Jiesheng; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang; Zucchelli, Stefano

    2016-03-10

    A search for the lepton-flavour violating decay $D^0 \\to e^\\pm \\mu^\\mp$ is made with a dataset corresponding to an integrated luminosity of $3.0$ fb$^{-1}$ of proton-proton collisions at centre-of-mass energies of $7$ TeV and $8$ TeV, collected by the LHCb experiment. Candidate $D^0$ mesons are selected using the decay $D^{*+} \\to D^0 \\pi^+$ and the $D^0 \\to e^\\pm \\mu^\\mp$ branching fraction is measured using the decay mode $D^0 \\to K^- \\pi^+$ as a normalisation channel. No significant excess of $D^0 \\to e^\\pm \\mu^\\mp$ candidates over the expected background is seen, and a limit is set on the branching fraction, $\\mathcal{B}(D^0 \\to e^\\pm \\mu^\\mp) < 1.3 \\times 10^{-8}$, at 90 % confidence level. This is an order of magnitude lower than the previous limit and it further constrains the parameter space in some leptoquark models and in supersymmetric models with R-parity violation.

  12. Resource Letter MP-3: The Manhattan Project and Related Nuclear Research

    Science.gov (United States)

    Reed, B. Cameron

    2016-10-01

    This Resource Letter is a supplement to the earlier Resource Letters MP-1 and MP-2, and provides further sources on the Manhattan Project and related research. Books, review papers, journal articles, videos, and websites are cited for the following topics: general works, technical works, biographical and autobiographical works, foreign wartime nuclear programs and related allied intelligence, the use of the bombs against Hiroshima and Nagasaki, technical papers of historical interest, postwar policy and technical developments, and educational materials. Together, these three Resource Letters describe nearly 400 sources of information on the Manhattan Project.

  13. The AgMIP Coordinated Climate-Crop Modeling Project (C3MP): Methods and Protocols

    Science.gov (United States)

    Shukla, Sonali P.; Ruane, Alexander Clark

    2014-01-01

    Climate change is expected to alter a multitude of factors important to agricultural systems, including pests, diseases, weeds, extreme climate events, water resources, soil degradation, and socio-economic pressures. Changes to carbon dioxide concentration ([CO2]), temperature, and water (CTW) will be the primary drivers of change in crop growth and agricultural systems. Therefore, establishing the CTW-change sensitivity of crop yields is an urgent research need and warrants diverse methods of investigation. Crop models provide a biophysical, process-based tool to investigate crop responses across varying environmental conditions and farm management techniques, and have been applied in climate impact assessment by using a variety of methods (White et al., 2011, and references therein). However, there is a significant amount of divergence between various crop models' responses to CTW changes (Rotter et al., 2011). While the application of a site-based crop model is relatively simple, the coordination of such agricultural impact assessments on larger scales requires consistent and timely contributions from a large number of crop modelers, each time a new global climate model (GCM) scenario or downscaling technique is created. A coordinated, global effort to rapidly examine CTW sensitivity across multiple crops, crop models, and sites is needed to aid model development and enhance the assessment of climate impacts (Deser et al., 2012). To fulfill this need, the Coordinated Climate-Crop Modeling Project (C3MP) (Ruane et al., 2014) was initiated within the Agricultural Model Intercomparison and Improvement Project (AgMIP; Rosenzweig et al., 2013). The submitted results from C3MP Phase 1 (February 15, 2013-December 31, 2013) are currently being analyzed. This chapter serves to present and update the C3MP protocols, discuss the initial participation and general findings, comment on needed adjustments, and describe continued and future development. AgMIP aims to improve

  14. ePRO-MP: A Tool for Profiling and Optimizing Energy and Performance of Mobile Multiprocessor Applications

    Directory of Open Access Journals (Sweden)

    Wonil Choi

    2009-01-01

    Full Text Available For mobile multiprocessor applications, achieving high performance with low energy consumption is a challenging task. In order to help programmers to meet these design requirements, system development tools play an important role. In this paper, we describe one such development tool, ePRO-MP, which profiles and optimizes both performance and energy consumption of multi-threaded applications running on top of Linux for ARM11 MPCore-based embedded systems. One of the key features of ePRO-MP is that it can accurately estimate the energy consumption of multi-threaded applications without requiring a power measurement equipment, using a regression-based energy model. We also describe another key benefit of ePRO-MP, an automatic optimization function, using two example problems. Using the automatic optimization function, ePRO-MP can achieve high performance and low power consumption without programmer intervention. Our experimental results show that ePRO-MP can improve the performance and energy consumption by 6.1% and 4.1%, respectively, over a baseline version for the co-running applications optimization example. For the producer-consumer application optimization example, ePRO-MP improves the performance and energy consumption by 60.5% and 43.3%, respectively over a baseline version.

  15. Performance Modeling of Hybrid MPI/OpenMP Scientific Applications on Large-scale Multicore Cluster Systems

    KAUST Repository

    Wu, Xingfu; Taylor, Valerie

    2011-01-01

    In this paper, we present a performance modeling framework based on memory bandwidth contention time and a parameterized communication model to predict the performance of OpenMP, MPI and hybrid applications with weak scaling on three large-scale multicore clusters: IBM POWER4, POWER5+ and Blue Gene/P, and analyze the performance of these MPI, OpenMP and hybrid applications. We use STREAM memory benchmarks to provide initial performance analysis and model validation of MPI and OpenMP applications on these multicore clusters because the measured sustained memory bandwidth can provide insight into the memory bandwidth that a system should sustain on scientific applications with the same amount of workload per core. In addition to using these benchmarks, we also use a weak-scaling hybrid MPI/OpenMP large-scale scientific application: Gyro kinetic Toroidal Code in magnetic fusion to validate our performance model of the hybrid application on these multicore clusters. The validation results for our performance modeling method show less than 7.77% error rate in predicting the performance of hybrid MPI/OpenMP GTC on up to 512 cores on these multicore clusters. © 2011 IEEE.

  16. Performance Modeling of Hybrid MPI/OpenMP Scientific Applications on Large-scale Multicore Cluster Systems

    KAUST Repository

    Wu, Xingfu

    2011-08-01

    In this paper, we present a performance modeling framework based on memory bandwidth contention time and a parameterized communication model to predict the performance of OpenMP, MPI and hybrid applications with weak scaling on three large-scale multicore clusters: IBM POWER4, POWER5+ and Blue Gene/P, and analyze the performance of these MPI, OpenMP and hybrid applications. We use STREAM memory benchmarks to provide initial performance analysis and model validation of MPI and OpenMP applications on these multicore clusters because the measured sustained memory bandwidth can provide insight into the memory bandwidth that a system should sustain on scientific applications with the same amount of workload per core. In addition to using these benchmarks, we also use a weak-scaling hybrid MPI/OpenMP large-scale scientific application: Gyro kinetic Toroidal Code in magnetic fusion to validate our performance model of the hybrid application on these multicore clusters. The validation results for our performance modeling method show less than 7.77% error rate in predicting the performance of hybrid MPI/OpenMP GTC on up to 512 cores on these multicore clusters. © 2011 IEEE.

  17. Post-exposure vaccination with MP-12 lacking NSs protects mice against lethal Rift Valley fever virus challenge.

    Science.gov (United States)

    Gowen, Brian B; Bailey, Kevin W; Scharton, Dionna; Vest, Zachery; Westover, Jonna B; Skirpstunas, Ramona; Ikegami, Tetsuro

    2013-05-01

    Rift Valley fever virus (RVFV) causes severe disease in humans and livestock. There are currently no approved antivirals or vaccines for the treatment or prevention of RVF disease in humans. A major virulence factor of RVFV is the NSs protein, which inhibits host transcription including the interferon (IFN)-β gene and promotes the degradation of dsRNA-dependent protein kinase, PKR. We analyzed the efficacy of the live-attenuated MP-12 vaccine strain and MP-12 variants that lack the NSs protein as post-exposure vaccinations. Although parental MP-12 failed to elicit a protective effect in mice challenged with wild-type (wt) RVFV by the intranasal route, significant protection was demonstrated by vaccination with MP-12 strains lacking NSs when they were administered at 20-30 min post-exposure. Viremia and virus replication in liver, spleen and brain were also inhibited by post-exposure vaccination with MP-12 lacking NSs. The protective effect was mostly lost when vaccination was delayed 6 or 24 h after intranasal RVFV challenge. When mice were challenged subcutaneously, efficacy of MP-12 lacking NSs was diminished, most likely due to more rapid dissemination of wt RVFV. Our findings suggest that post-exposure vaccination with MP-12 lacking NSs may be developed as a novel post-exposure treatment to prevent RVF. Copyright © 2013 Elsevier B.V. All rights reserved.

  18. Penetrating adolescents' mental models of mp3 with ZMET.

    Science.gov (United States)

    Ling, I-Ling; Yang, Chun-Ming; Liu, Yi-Fen; Tsai, Yu-Hsuan

    2009-01-01

    This article demonstrates the application of the Zaltman metaphor-elicitation technique (ZMET) to help adolescent consumers delve into their unconscious thoughts and provide them with insights into the use of mp3. An analysis of interview transcripts and images revealed that the ZMET process provides a description of how the knowledge structures of adolescent consumers are subdivided and grouped around important themes that frame and motivate their involvement with a product. The findings reveal that there are 33 themes of consumer knowledge structure toward mp3. Furthermore, among these themes, there are four major concepts: size/form, convenience, relaxation, comfort, and appearance. The respondents' minds include not only rational components but emotional ingredients. Notably, the results also show that music can be an effective metaphor in the application of the ZMET method.

  19. Search for the decay $B_s^0 \\to D^{*\\mp} \\pi^\\pm$

    CERN Document Server

    INSPIRE-00258707; Abellan Beteta, C; Adeva, B; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves Jr, A A; Amato, S; Amerio, S; Amhis, Y; Anderlini, L; Anderson, J; Andreassen, R; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Bachmann, S; Back, J J; Baesso, C; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bauer, Th; Bay, A; Beddow, J; Bedeschi, F; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Benayoun, M; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M -O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bowen, E; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Burducea, I; Bursche, A; Busetto, G; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carranza-Mejia, H; Carson, L; Carvalho Akiba, K; Casse, G; Cattaneo, M; Cauet, Ch; Charles, M; Charpentier, Ph; Chen, P; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Cogneras, E; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Coquereau, S; Corti, G; Couturier, B; Cowan, G A; Craik, D; Cunliffe, S; Currie, R; D'Ambrosio, C; David, P; David, P N Y; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Oyanguren Campos, M; De Paula, L; De Silva, W; De Simone, P; Decamp, D; Deckenhoff, M; Del Buono, L; Derkach, D; Deschamps, O; Dettori, F; Di Canto, A; Dijkstra, H; Dogaru, M; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Elsby, D; Falabella, A; Färber, C; Fardell, G; Farinelli, C; Farry, S; Fave, V; Ferguson, D; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furcas, S; Furfaro, E; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garofoli, J; Garosi, P; Garra Tico, J; Garrido, L; Gaspar, C; Gauld, R; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hampson, T; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Hartmann, T; He, J; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicks, E; Hill, D; Hoballah, M; Hombach, C; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Hussain, N; Hutchcroft, D; Hynds, D; Iakovenko, V; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jans, E; Jaton, P; Jing, F; John, M; Johnson, D; Jones, C R; Jost, B; Kaballo, M; Kandybei, S; Karacson, M; Karbach, T M; Kenyon, I R; Kerzel, U; Ketel, T; Keune, A; Khanji, B; Kochebina, O; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucharczyk, M; Kudryavtsev, V; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J -P; Lefèvre, R; Leflat, A; Lefrançois, J; Leo, S; Leroy, O; Leverington, B; Li, Y; Li Gioi, L; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; von Loeben, J; Lohn, S; Lopes, J H; Lopez Asamar, E; Lopez-March, N; Lu, H; Lucchesi, D; Luisier, J; Luo, H; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Malde, S; Manca, G; Mancinelli, G; Marconi, U; Märki, R; Marks, J; Martellotti, G; Martens, A; Martin, L; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Martins Tostes, D; Massafferri, A; Matev, R; Mathe, Z; Matteuzzi, C; Maurice, E; Mazurov, A; McCarthy, J; McNulty, R; Mcnab, A; Meadows, B; Meier, F; Meissner, M; Merk, M; Milanes, D A; Minard, M -N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Morello, M J; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neufeld, N; Nguyen, A D; Nguyen, T D; Nguyen-Mau, C; Nicol, M; Niess, V; Niet, R; Nikitin, N; Nikodem, T; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Pal, B K; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perego, D L; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pessina, G; Petridis, K; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pietrzyk, B; Pilař, T; Pinci, D; Playfer, S; Plo Casasus, M; Polci, F; Polok, G; Poluektov, A; Polycarpo, E; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Redford, S; Reid, M M; dos Reis, A C; Ricciardi, S; Richards, A; Rinnert, K; Rives Molina, V; Roa Romero, D A; Robbe, P; Rodrigues, E; Rodriguez Perez, P; Roiser, S; Romanovsky, V; Romero Vidal, A; Rouvinet, J; Ruf, T; Ruffini, F; Ruiz, H; Ruiz Valls, P; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salzmann, C; Sanmartin Sedes, B; Sannino, M; Santacesaria, R; Santamarina Rios, C; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Savrina, D; Schaack, P; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M -H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Senderowska, K; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shatalov, P; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Skwarnicki, T; Smith, N A; Smith, E; Smith, M; Sokoloff, M D; Soler, F J P; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Swientek, S; Syropoulos, V; Szczekowski, M; Szczypka, P; Szumlak, T; T'Jampens, S; Teklishyn, M; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Tonelli, D; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tresch, M; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ubeda Garcia, M; Ukleja, A; Urner, D; Uwer, U; Vagnoni, V; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Vieira, D; Vilasis-Cardona, X; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; Voss, H; Waldi, R; Wallace, R; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wicht, J; Wiechczynski, J; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wishahi, J; Witek, M; Wotton, S A; Wright, S; Wu, S; Wyllie, K; Xie, Y; Xing, F; Xing, Z; Yang, Z; Young, R; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhokhov, A; Zhong, L; Zvyagin, A

    2013-01-01

    A search for the decay $B_s^0 \\to D^{*\\mp} \\pi^\\pm$ is presented using a data sample corresponding to an integrated luminosity of $1.0 \\ {\\rm fb}^{-1}$ of $pp$ collisions collected by LHCb. This decay is expected to be mediated by a $W$-exchange diagram, with little contribution from rescattering processes, and therefore a measurement of the branching fraction will help to understand the mechanism behind related decays such as $B_s^0 \\to \\pi^+\\pi^-$ and $B_s^0 \\to D \\overline{D}$. Systematic uncertainties are minimised by using $B^0 \\to D^{*\\mp} \\pi^\\pm$ as a normalisation channel. We find no evidence for a signal, and set an upper limit on the branching fraction of ${\\cal B}(B_s^0 \\to D^{*\\mp} \\pi^\\pm) < 6.1\\,\\left(7.8\\right) \\times 10^{-6}$ at 90% (95%) confidence level.

  20. Sir William Mitchell (1925-2002)

    CERN Multimedia

    2002-01-01

    Sir William (Bill) Mitchell, former President of the CERN Council, died on 30th October 2002 at the age of 77. Mitchell was professor of Physics at Oxford University from 1978 to 1989, having previously been Professor of Physics, Dean of Science and Deputy Vice-Chancellor at Reading University. From 1985 to 1990 he was Chairman of the UK's Science and Engineering Research Council (SERC), which at the time was the funding agency for the UK's participation in the CERN programme. As Chairman, Mitchell was one of the UK representatives on the CERN Council, and in 1991 he was elected President, a position he held for three years. This was a difficult period for CERN. Financial problems were being faced in many member states, notably in Germany as a result of unification. This led to calls for reductions in the CERN budget and, more significantly, to requests for delays in consderation of future programmes. On the other hand for the future of CERN and the progress of elementary particle physics, it was necessary...

  1. The optimal dynamic immunization under a controlled heterogeneous node-based SIRS model

    Science.gov (United States)

    Yang, Lu-Xing; Draief, Moez; Yang, Xiaofan

    2016-05-01

    Dynamic immunizations, under which the state of the propagation network of electronic viruses can be changed by adjusting the control measures, are regarded as an alternative to static immunizations. This paper addresses the optimal dynamical immunization under the widely accepted SIRS assumption. First, based on a controlled heterogeneous node-based SIRS model, an optimal control problem capturing the optimal dynamical immunization is formulated. Second, the existence of an optimal dynamical immunization scheme is shown, and the corresponding optimality system is derived. Next, some numerical examples are given to show that an optimal immunization strategy can be worked out by numerically solving the optimality system, from which it is found that the network topology has a complex impact on the optimal immunization strategy. Finally, the difference between a payoff and the minimum payoff is estimated in terms of the deviation of the corresponding immunization strategy from the optimal immunization strategy. The proposed optimal immunization scheme is justified, because it can achieve a low level of infections at a low cost.

  2. An SIRS model with a nonlinear incidence rate

    International Nuclear Information System (INIS)

    Jin Yu; Wang, Wendi; Xiao Shiwu

    2007-01-01

    The global dynamics of an SIRS model with a nonlinear incidence rate is investigated. We establish a threshold for a disease to be extinct or endemic, analyze the existence and asymptotic stability of equilibria, and verify the existence of bistable states, i.e., a stable disease free equilibrium and a stable endemic equilibrium or a stable limit cycle. In particular, we find that the model admits stability switches as a parameter changes. We also investigate the backward bifurcation, the Hopf bifurcation and Bogdanov-Takens bifurcation and obtain the Hopf bifurcation criteria and Bogdanov-Takens bifurcation curves, which are important for making strategies for controlling a disease

  3. Thermo Active Building Systems(TABS) - Performance in practice and possibilities for optimization

    DEFF Research Database (Denmark)

    Kolarik, Jakub

    The project “Thermo Active Building Systems (TABS) – Performance in practice and possibilities for optimization” was carried out at DTU Byg in the period form 1.9.2012 until 31.12.2014. The aim of the project was to conduct field measurements in modern office buildings equipped with TABS systems...

  4. An Ultra-High Field Study of Cerebellar Pathology in Early Relapsing-Remitting Multiple Sclerosis Using MP2RAGE.

    Science.gov (United States)

    Fartaria, Mário João; OʼBrien, Kieran; Şorega, Alexandra; Bonnier, Guillaume; Roche, Alexis; Falkovskiy, Pavel; Krueger, Gunnar; Kober, Tobias; Bach Cuadra, Meritxell; Granziera, Cristina

    2017-05-01

    The aim of this study was to study focal cerebellar pathology in early stages of multiple sclerosis (MS) using ultra-high-field magnetization-prepared 2 inversion-contrast rapid gradient-echo (7T MP2RAGE). Twenty early-stage relapsing-remitting MS patients underwent an MP2RAGE acquisition at 7 T magnetic resonance imaging (MRI) (images acquired at 2 different resolutions: 0.58 × 0.58 × 0.58 mm, 7T_0.58, and 0.75 × 0.75 × 0.90 mm, 7T_0.75) and 3 T MRI (1.0 × 1.0 × 1.2 mm, 3T_1.0). Total cerebellar lesion load and volume and mean cerebellar lesion volume were compared across images using a Wilcoxon signed-rank test. Mean T1 relaxation times in lesions and normal-appearing tissue as well as contrast-to-noise ratio (CNR) measurements were also compared using a Wilcoxon signed-rank test. A multivariate analysis was applied to assess the contribution of MRI metrics to clinical performance in MS patients. Both 7T_0.58 and 7T_0.75 MP2RAGE showed significantly higher lesion load compared with 3T_1.0 MP2RAGE (P < 0.001). Plaques that were judged as leukocortical in 7T_0.75 and 3T_1.0 MP2RAGEs were instead identified as WM lesions in 7T_0.58 MP2RAGE. Cortical lesion CNR was significantly higher in MP2RAGEs at 7 T than at 3 T. Total lesion load as well as total and mean lesion volume obtained at both 7 T and 3 T MP2RAGE significantly predicted attention (P < 0.05, adjusted R = 0.5), verbal fluency (P < 0.01, adjusted R = 0.6), and motor performance (P = 0.01, adjusted R = 0.7). This study demonstrates the value of 7 T MP2RAGE to study the cerebellum in early MS patients. 7T_0.58 MP2RAGE provides a more accurate anatomical description of white and gray matter pathology compared with 7T_0.75 and 3T_1.0 MP2RAGE, likely due to the improved spatial resolution, lower partial volume effects, and higher CNR.

  5. Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.

    Science.gov (United States)

    Ondracek, Caitlin R; Frappier, Vincent; Ringel, Alison E; Wolberger, Cynthia; Guarente, Leonard

    2017-03-07

    Sirtuin enzymes depend on NAD + to catalyze protein deacetylation. Therefore, the lowering of NAD + during aging leads to decreased sirtuin activity and may speed up aging processes in laboratory animals and humans. In this study, we used a genetic screen to identify two mutations in the catalytic domain of yeast Sir2 that allow the enzyme to function in an NAD + -depleted environment. These mutant enzymes give rise to a significant increase of yeast replicative lifespan and increase deacetylation by the Sir2 ortholog, SIRT1, in mammalian cells. Our data suggest that these mutations increase the stability of the conserved catalytic sirtuin domain, thereby increasing the catalytic efficiency of the mutant enzymes. Our approach to identifying sirtuin mutants that permit function in NAD + -limited environments may inform the design of small molecules that can maintain sirtuin activity in aging organisms. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  6. Strategies for the prevention of MP3-induced hearing loss among adolescents: expert opinions from a Delphi study.

    Science.gov (United States)

    Vogel, Ineke; Brug, Johannes; van der Ploeg, Catharina P B; Raat, Hein

    2009-05-01

    To identify parties involved in the prevention of MP3-induced hearing loss among adolescents and potentially effective prevention strategies and interventions. Thirty experts in fields such as scientific research, medical practice, community health professions, education, youth work, music entertainment, and enforcement authorities participated in a qualitative, electronic, 3-round, Web-based Delphi study. Multiple parties involved in the prevention of MP3-induced hearing loss among adolescents were identified; the most relevant are the adolescents themselves, their parents, manufacturers of MP3 players and earphones, and the authorities. The experts did not expect that adolescents in general would perform the necessary protective behaviors to prevent MP3-induced hearing loss. Two environmental health protection measures were identified as both relevant and feasible to be implemented (ie, authorities encourage manufacturers to produce safer products, and public health campaigns will be held to improve knowledge of the risks of high-volume music, possible protective measures, and consequences of hearing loss). Authorities, the music industry in general, and especially manufacturers of MP3 players and earphones should recognize their responsibility and create a safer MP3-listening environment by taking measures to protect today's youth from the dangers of listening to high-volume music on MP3 players.

  7. Intermittency in super-high energy cosmic ray events

    International Nuclear Information System (INIS)

    Gladysz-Dziadus, E.

    1988-12-01

    The factorial moments method described by Bialas and Peschanski was used for investigations of fluctuations in pseudorapidity distributions of nine cosmic-ray events at energy of about 1000 TeV. Both electromagnetic and hadronic components of these events reveal very strong intermittent behaviour. 8 refs., 7 figs., 2 tabs. (author)

  8. Optimizing the magnetization-prepared rapid gradient-echo (MP-RAGE sequence.

    Directory of Open Access Journals (Sweden)

    Jinghua Wang

    Full Text Available The three-dimension (3D magnetization-prepared rapid gradient-echo (MP-RAGE sequence is one of the most popular sequences for structural brain imaging in clinical and research settings. The sequence captures high tissue contrast and provides high spatial resolution with whole brain coverage in a short scan time. In this paper, we first computed the optimal k-space sampling by optimizing the contrast of simulated images acquired with the MP-RAGE sequence at 3.0 Tesla using computer simulations. Because the software of our scanner has only limited settings for k-space sampling, we then determined the optimal k-space sampling for settings that can be realized on our scanner. Subsequently we optimized several major imaging parameters to maximize normal brain tissue contrasts under the optimal k-space sampling. The optimal parameters are flip angle of 12°, effective inversion time within 900 to 1100 ms, and delay time of 0 ms. In vivo experiments showed that the quality of images acquired with our optimal protocol was significantly higher than that of images obtained using recommended protocols in prior publications. The optimization of k-spacing sampling and imaging parameters significantly improved the quality and detection sensitivity of brain images acquired with MP-RAGE.

  9. 3D-mainosvideo teollisuusyritykselle : Case: Leppäkosken Lämpö

    OpenAIRE

    Utriainen, Sari

    2015-01-01

    Toimeksiantajana opinnäytetyölle toimi biolämmitysjärjestelmiä valmistava ja markkinoiva Ariterm Oy. Tavoitteena oli tuottaa messu- ja markkinointikäyttöön 3D-mainosvideo Ariterm Oy:n toimittamasta, elokuussa 2014 käyttöönotetusta Leppäkosken Lämpö Oy:n pellettilämpölaitoksesta. Opinnäytetyössä käsiteltiin 3D-mallien hyödyntämistä eri teollisuuden aloilla sekä tutustuttiin 3D-mainosvideoprojektissa käytettyihin ohjelmistoihin ja teollisuuden 3D-suunnitteluohjelmien eri tiedostomuotoihin se...

  10. MP3 players and hearing loss: adolescents' perceptions of loud music and hearing conservation.

    Science.gov (United States)

    Vogel, Ineke; Brug, Johannes; Hosli, Esther J; van der Ploeg, Catharina P B; Raat, Hein

    2008-03-01

    To explore adolescents' behaviors and opinions about exposure to loud music from MP3 players. We conducted a qualitative analysis of focus-group discussions with adolescents aged 12 to 18 years from 2 large secondary schools (1 urban and 1 rural) for pre-vocational and pre-university education. The semi-structured question route was theoretically framed within the protection motivation theory. Most adolescents-especially male students and students from pre-vocational schools-indicated that they often played their MP3 players at maximum volume. Although they appeared to be generally aware of the risks of exposure to loud music, they expressed low personal vulnerability to music-induced hearing loss. Most adolescents said that they would not accept any interference with their music-exposure habits. Interventions should target students from pre-vocational schools and should focus on increasing adolescents' knowledge of the risks of loud music and how to protect themselves. Besides hearing education for adolescents and technical modifications of MP3 players, volume-level regulations for MP3 players may be warranted.

  11. Threshold Dynamics of a Stochastic SIR Model with Vertical Transmission and Vaccination

    OpenAIRE

    Miao, Anqi; Zhang, Jian; Zhang, Tongqian; Pradeep, B. G. Sampath Aruna

    2017-01-01

    A stochastic SIR model with vertical transmission and vaccination is proposed and investigated in this paper. The threshold dynamics are explored when the noise is small. The conditions for the extinction or persistence of infectious diseases are deduced. Our results show that large noise can lead to the extinction of infectious diseases which is conducive to epidemic diseases control.

  12. Bora Bora, Tahaa, and Raiatea, French Polynesia, Landsat and SIR-C Images Compared to SRTM Shaded

    Science.gov (United States)

    2005-01-01

    Bora Bora, Tahaa, and Raiatea (top to bottom) are Polynesian Islands about 220 kilometers (135 miles) west-northwest of Tahiti in the South Pacific. Each of the islands is surrounded by a coral reef and its associated islets ('motus') that enclose a lagoon. Actually, as seen here, Tahaa and Raiatea are close enough together to share a common lagoon and reef. These islands are volcanic in origin and were built up from the sea floor by lava extrusions millions of years ago. None is now active, and all are deeply eroded. This display compares three differing 'views from space' of these islands. On the left, an image from the Landsat 7 satellite shows the islands as they might have appeared to an astronaut in orbit in 1999 (but a little sharper and with atmospheric haze suppressed). In the middle is an image created from data gathered by the third-generation Shuttle Imaging Radar (SIR-C), flown in 1994. On the right is a graphic illustrating elevation data gathered by the Shuttle Radar Topography Mission (SRTM) in 2000. Each of these images shows very different information as compared to the other two. Landsat sees clouds, which are almost always above these islands, blocking the view of the terrain. It also readily sees through shallow water down to the reefs. SIR-C sees the waves and other effects of winds upon the ocean surface. It does not look through water to see the reefs, but it clearly separates land and water. It also provides a bolder (but distorted) view of the islands' topographic patterns. With the ability of radar to see through clouds and provision of its own illumination, the SIR-C view is not limited by clouds nor their shadows. SRTM was designed to provide new information that is missing in the Landsat and SIR-C views. Specifically, SRTM created the world's first near-global, detailed elevation model. Natural topographic shading in Landsat imagery and radar topographic shadowing of SIR-C give some evidence of the shape of the ground but do not

  13. First observation and measurement of the branching fraction for the decay $B^0_s \\to D_s^{*\\mp} K^{\\pm}$

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Anderson, Jonathan; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Bel, Lennaert; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bertolin, Alessandro; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Bizzeti, Andrea; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Braun, Svende; Brett, David; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Brook, Nicholas; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Campana, Pierluigi; Campora Perez, Daniel; Capriotti, Lorenzo; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carniti, Paolo; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casanova Mohr, Raimon; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cavallero, Giovanni; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cogoni, Violetta; Cojocariu, Lucian; Collazuol, Gianmaria; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Crocombe, Andrew; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pieter; Davis, Adam; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Dey, Biplab; Di Canto, Angelo; Di Ruscio, Francesco; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dreimanis, Karlis; Dujany, Giulio; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farley, Nathanael; Farry, Stephen; Fay, Robert; Ferguson, Dianne; Fernandez Albor, Victor; Ferrari, Fabio; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fol, Philip; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; García Pardiñas, Julián; Garofoli, Justin; Garra Tico, Jordi; Garrido, Lluis; Gascon, David; Gaspar, Clara; Gastaldi, Ugo; Gauld, Rhorry; Gavardi, Laura; Gazzoni, Giulio; Geraci, Angelo; Gerick, David; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianelle, Alessio; Gianì, Sebastiana; Gibson, Valerie; Giubega, Lavinia-Helena; Gligorov, V.V.; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graverini, Elena; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Humair, Thibaud; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jawahery, Abolhassan; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Karodia, Sarah; Kelsey, Matthew; Kenyon, Ian; Kenzie, Matthew; Ketel, Tjeerd; Khanji, Basem; Khurewathanakul, Chitsanu; Klaver, Suzanne; Klimaszewski, Konrad; Kochebina, Olga; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Lohn, Stefan; Longstaff, Iain; Lopes, Jose; Lowdon, Peter; Lucchesi, Donatella; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Machefert, Frederic; Maciuc, Florin; Maev, Oleg; Malde, Sneha; Malinin, Alexander; Manca, Giulia; Mancinelli, Giampiero; Manning, Peter Michael; Mapelli, Alessandro; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Märki, Raphael; Marks, Jörg; Martellotti, Giuseppe; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massafferri, André; Matev, Rosen; Mathad, Abhijit; Mathe, Zoltan; Matteuzzi, Clara; Mauri, Andrea; Maurin, Brice; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; Meadows, Brian; Meier, Frank; Meissner, Marco; Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Mitzel, Dominik Stefan; Molina Rodriguez, Josue; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Müller, Katharina; Mussini, Manuel; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Osorio Rodrigues, Bruno; Otalora Goicochea, Juan Martin; Otto, Adam; Owen, Patrick; Oyanguren, Maria Aranzazu; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parkes, Christopher; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Perret, Pascal; Pescatore, Luca; Petridis, Konstantinos; Petrolini, Alessandro; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Pistone, Alessandro; Playfer, Stephen; Plo Casasus, Maximo; Poikela, Tuomas; Polci, Francesco; Poluektov, Anton; Polyakov, Ivan; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Price, Eugenia; Price, Joseph David; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Quagliani, Renato; Rachwal, Bartolomiej; Rademacker, Jonas; Rakotomiaramanana, Barinjaka; Rama, Matteo; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Redi, Federico; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vincente; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Lopez, Jairo Alexis; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rouvinet, Julien; Ruf, Thomas; Ruiz, Hugo; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Sepp, Indrek; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Silva Coutinho, Rafael; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skillicorn, Ian; Skwarnicki, Tomasz; Smith, Edmund; Smith, Eluned; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Steinkamp, Olaf; Stenyakin, Oleg; Sterpka, Christopher Francis; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Stroili, Roberto; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szczypka, Paul; Szumlak, Tomasz; T'Jampens, Stephane; Teklishyn, Maksym; Tellarini, Giulia; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Todd, Jacob; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Trabelsi, Karim; Tran, Minh Tâm; Tresch, Marco; Trisovic, Ana; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viana Barbosa, Joao Vitor; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Weiden, Andreas; Whitehead, Mark; Wiedner, Dirk; Wilkinson, Guy; Wilkinson, Michael; Williams, Mark Richard James; Williams, Matthew; Williams, Mike; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wyllie, Kenneth; Xie, Yuehong; Xu, Zhirui; Yang, Zhenwei; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang

    2015-06-18

    The first observation of the $B^0_s \\to D_s^{*\\mp} K^{\\pm}$ decay is reported using 3.0$fb^{-1}$ of proton-proton collision data collected by the LHCb experiment. The $D_s^{*\\mp}$ mesons are reconstructed through the decay chain $D_s^{*\\mp} \\to \\gamma D_s^{\\mp}(K^{\\mp}K^{\\pm}\\pi^{\\mp})$. The branching fraction relative to that for $B^0_s \\to D_s^{*-} \\pi^{+}$ is measured to be $0.068 \\pm 0.005 ^{+0.003}_{-0.002}$, where the first uncertainty is statistical and the second is systematic. Using a recent measurement of $BR(B^0_s \\to D_s^{*-} \\pi^{+})$ the absolute branching fraction of $B^0_s \\to D_s^{*\\mp} K^{\\pm}$ is measured as ( 16.3 $\\pm$ 1.2 (stat) $^{+0.7}_{-0.5}$ (syst) $\\pm$ 4.8 (norm) ) $\\times$ 10$^{-5}$, where the third uncertainty is due to the uncertainty on the branching fraction of the normalisation channel.

  14. A Proposal for User-defined Reductions in OpenMP

    Energy Technology Data Exchange (ETDEWEB)

    Duran, A; Ferrer, R; Klemm, M; de Supinski, B R; Ayguade, E

    2010-03-22

    Reductions are commonly used in parallel programs to produce a global result from partial results computed in parallel. Currently, OpenMP only supports reductions for primitive data types and a limited set of base language operators. This is a significant limitation for those applications that employ user-defined data types (e. g., objects). Implementing manual reduction algorithms makes software development more complex and error-prone. Additionally, an OpenMP runtime system cannot optimize a manual reduction algorithm in ways typically applied to reductions on primitive types. In this paper, we propose new mechanisms to allow the use of most pre-existing binary functions on user-defined data types as User-Defined Reduction (UDR) operators. Our measurements show that our UDR prototype implementation provides consistently good performance across a range of thread counts without increasing general runtime overheads.

  15. Light Weight MP3 Watermarking Method for Mobile Terminals

    Science.gov (United States)

    Takagi, Koichi; Sakazawa, Shigeyuki; Takishima, Yasuhiro

    This paper proposes a novel MP3 watermarking method which is applicable to a mobile terminal with limited computational resources. Considering that in most cases the embedded information is copyright information or metadata, which should be extracted before playing back audio contents, the watermark detection process should be executed at high speed. However, when conventional methods are used with a mobile terminal, it takes a considerable amount of time to detect a digital watermark. This paper focuses on scalefactor manipulation to enable high speed watermark embedding/detection for MP3 audio and also proposes the manipulation method which minimizes audio quality degradation adaptively. Evaluation tests showed that the proposed method is capable of embedding 3 bits/frame information without degrading audio quality and detecting it at very high speed. Finally, this paper describes application examples for authentication with a digital signature.

  16. Treatment of non-vital primary molar using lesion sterilization and tissue repair (LSTR 3Mix-MP

    Directory of Open Access Journals (Sweden)

    Tania Saskianti

    2013-06-01

    Full Text Available Background: Root canal preparation and anatomic variations of deciduous teeth often cause the child patient uncooperative and sometimes the treatment failure. the non-threatening treatment and non-invasive approaches is needed to obtain a good cooperation from child patient. Purpose: The study was aimed to clinically evaluate the use of 3Mix-MP- a combination of antibacterial drugs, i.e. metronidazole, minocycline and ciprofloxacin (3Mix, and macrogol and propylene glycol (MP - as pulp medicament on a necroses primary molar. Methods: Subject were the children patients of Pediatric Dental Clinic Universitas Airlangga Dental Hospital. Eight primary molars with pulp necroses due to dental caries were selected as samples. The treatment was done based on the concept of lesion sterilization and tissue repair (LSTR therapy. A slice of 3 Mix-MP pastes was placed in the cavity and then sealed with glassionomer cement. Subjects were asked for recall visit in 1, 3 and 6 months post treatment, for clinical and radiographic evaluation. The antibacterial effect of 3 Mix-MP was compared with tempophore on mixed bacteria of pulp cavity which was isolated prior to therapy. The antibacterial effect was determined by measuring the inhibition zone after 24 hours anaerobe incubation. Results: Seven out of 8 subjects on recall visit showed no acute or chronic clinical symptoms, such as fistulae, abscess, purulent exudates, swelling or feel any pain during mastication. Microbiological test result showed LSTR 3Mix-MP had antibacterial effect higher than tempophore (p<0.001. Conclusion: The study revealed that 3Mix-MP treatment showed clinical and radiographic positive response on necrose primary molar.Latar belakang: Preparasi saluran akar dan variasi anatomi gigi sulung seringkali menyebabkan pasien anak tidak kooperatif dan kadang menyebabkan kegagalan perawatan. Perawatan yang tidak menakutkan dan non-invasif diperlukan untuk mendapatkan kerjasama yang baik dari

  17. TabSQL: a MySQL tool to facilitate mapping user data to public databases.

    Science.gov (United States)

    Xia, Xiao-Qin; McClelland, Michael; Wang, Yipeng

    2010-06-23

    With advances in high-throughput genomics and proteomics, it is challenging for biologists to deal with large data files and to map their data to annotations in public databases. We developed TabSQL, a MySQL-based application tool, for viewing, filtering and querying data files with large numbers of rows. TabSQL provides functions for downloading and installing table files from public databases including the Gene Ontology database (GO), the Ensembl databases, and genome databases from the UCSC genome bioinformatics site. Any other database that provides tab-delimited flat files can also be imported. The downloaded gene annotation tables can be queried together with users' data in TabSQL using either a graphic interface or command line. TabSQL allows queries across the user's data and public databases without programming. It is a convenient tool for biologists to annotate and enrich their data.

  18. Patterns of Gram-stained fecal flora as a quick diagnostic marker in patients with severe SIRS.

    Science.gov (United States)

    Shimizu, Kentaro; Ogura, Hiroshi; Tomono, Kazunori; Tasaki, Osamu; Asahara, Takashi; Nomoto, Koji; Morotomi, Masami; Matsushima, Asako; Nakahori, Yasutaka; Yamano, Shuhei; Osuka, Akinori; Kuwagata, Yasuyuki; Sugimoto, Hisashi

    2011-06-01

    The gut is an important target organ of injury during critically ill conditions. Although Gram staining is a common and quick method for identifying bacteria, its clinical application has not been fully evaluated in critically ill conditions. This study's aims were to identify patterns of Gram-stained fecal flora and compare them to cultured bacterial counts and to investigate the association between the patterns and septic complications in patients with severe systemic inflammatory response syndrome (SIRS). Fifty-two patients with SIRS were included whose Gram-stained fecal flora was classified into three patterns. In a diverse pattern, large numbers of multiple kinds of bacteria completely covered the field. In a single pattern, one specific kind of bacteria or fungi predominantly covered the field. In a depleted pattern, most bacteria were diminished in the field. In the analysis of fecal flora, the numbers of total obligate anaerobes in the depleted pattern was significantly lower than those in the diverse pattern and single pattern (p Gram-stained fecal flora can be classified into three patterns and are associated with both cultured bacterial counts and clinical information. Gram-stained fecal bacteria can be used as a quick bedside diagnostic marker for severe SIRS patients.

  19. Some algorithms of the events recognition in the Tagged Neutrino Facility

    International Nuclear Information System (INIS)

    Mukhin, S.A.

    1993-01-01

    Some algorithms of the events recognition in Tagged Neutrino Facility are described: the event localization in Bars neutrino detector, the off-line trigger, the reconstruction of events vertex, events reconstruction in Tagging Station. The programming package for realization of clusterization methods that have been used for mentioned algorithms realization is presented. 6 refs., 2 tabs

  20. T1 mapping of the mouse brain following fractionated manganese administration using MP2RAGE.

    Science.gov (United States)

    Driencourt, Luc; Romero, Carola Jacqueline; Lepore, Mario; Eggenschwiler, Florent; Reynaud, Olivier; Just, Nathalie

    2017-01-01

    With the increasing development of transgenic mouse models of neurodegenerative diseases allowing improved understanding of the underlying mechanisms of these disorders, robust quantitative mapping techniques are also needed in rodents. MP2RAGE has shown great potential for structural imaging in humans at high fields. In the present work, MP2RAGE was successfully implemented at 9.4T and 14.1T. Following fractionated injections of MnCl 2 , MP2RAGE images were acquired allowing simultaneous depiction and T 1 mapping of structures in the mouse brain at both fields. In addition, T 1 maps demonstrated significant T 1 shortenings in different structures of the mouse brain (p < 0.0008 at 9.4T, p < 0.000001 at 14.1T). T 1 values recovered to the levels of saline-injected animals 1 month after the last injection except in the pituitary gland. We believe that MP2RAGE represents an important prospective translational tool for further structural MRI.

  1. Hábitos tabágicos em alunos do 6.º ano de Medicina e medidas anti-tabágicas

    Directory of Open Access Journals (Sweden)

    André Borges

    2008-05-01

    Full Text Available Resumo: Objectivos: Estudar os hábitos tabágicos, caracterizar o conhecimento, aceitação de medidas anti-tabágicas e as expectativas em relação ao impacto destas na saúde pública em alunos do 6.º ano de Medicina, em Portugal.Material e métodos: Foi realizado um estudo descritivo transversal, cuja população alvo foram os alunos de Medicina do sexto ano, em Portugal. Foi utilizado um questionário auto-preenchido, anónimo, dispo-nibilizado numa página online, que divulgámos por correio electrónico. Para a análise de algumas variá-veis utilizamos tabelas de contingência e a prova do χ2, com nível de significância de 0,05.Resultados: Obtivemos 255 questionários válidos. A taxa de fumadores foi de 18,04%. O consumo de cigarros mais frequente foi entre 1-10 cigarros, sendo mais elevado entre os homens. A idade de início da maioria foi entre 13-18 anos, com as mulheres a co-meçarem mais tarde. Dos fumadores, 36,96% já fize-ram uma tentativa de cessação tabágica. A maioria dos inquiridos concorda com as medidas anti-tabágicas inquiridas e considera que irão diminuir o consumo e a morbimortalidade da população em geral. A formação sobre cessação tabágica foi considerada suficiente por 34,90%.Conclusões: Os resultados obtidos estão de acordo com as características da população em geral, nomea-damente quanto à prevalência de fumadores, idade de início do consumo de tabaco e elevada prevalência de mulheres fumadoras. As medidas anti-tabágicas parecem reunir consenso, segundo a nossa amostra, que também espera uma redução do consumo geral e individual, assim como da morbimortalidade.Rev Port Pneumol 2008; XIV (3: 379-390 Abstract: Objectives: To study the smoking habits of 6th year Portuguese medical students and assess their knowledge and acceptance of anti-smoking measures and how they felt these

  2. Hábitos tabágicos em alunos do 6.º ano de Medicina e medidas anti-tabágicas

    Directory of Open Access Journals (Sweden)

    André Borges

    2008-03-01

    Full Text Available Resumo: Objectivos: Estudar os hábitos tabágicos, caracterizar o conhecimento, a aceitação de medidas anti-tabágicas e as expectativas em relação ao impacto destas na saúde pública em alunos do 6.º ano de Medicina, em Portugal.Material e métodos: Foi realizado um estudo descritivo transversal, cuja população-alvo foram os alunos de Medicina do sexto ano em Portugal. Foi utilizado um questionário auto-preenchido, anónimo, disponibilizado numa página online, que divulgámos por correio electrónico. Para a análise de algumas variáveis, utilizámos tabelas de contingência e a prova do χ2, com nível de significância de 0,05.Resultados: Obtivemos 255 questionários válidos. A taxa de fumadores foi de 18,04%. O consumo de cigarros mais frequente foi entre 1-10, sendo mais elevado entre os homens. A idade de início da maioria foi entre 13-18 anos, com as mulheres a começarem mais tarde. Dos fumadores, 36,96% já fizeram uma tentativa de cessação tabágica. A maioria dos inquiridos concorda com as medidas anti-tabágicas inquiridas e considera que irão diminuir o consumo e a morbimortalidade da população em geral. A formação sobre cessação tabágica foi considerada suficiente por 34,90%.Conclusões: Os resultados obtidos estão de acordo com as características da população em geral, nomeadamente quanto à prevalência de fumadores, idade de início do consumo de tabaco e elevada prevalência de mulheres fumadoras. As medidas anti-tabágicas parecem reunir consenso, segundo a nossa amostra, que também espera uma redução do consumo geral e individual, assim como da morbimortalidade.Rev Port Pneumol 2007; XIV (2: 219-230 Abstract: Objectives: To study the smoking habits of 6th year Portuguese medical students and assess their knowledge and acceptance of anti-smoking measures and how they felt these would

  3. sir, besoin, dépendance : l'addiction comme (épreuve de la modernité

    Directory of Open Access Journals (Sweden)

    Rita Di Lorenzo

    2016-04-01

    Full Text Available La frontière entre la santé et la pathologie est un lieu fascinant et dangereux, au caractère poreux et riche de familiarités des deux côtés, inavouées et coûteuses. Le terme d’addiction semble s’installer précisément sur cette frontière, gagnant en étendue médiatique ce qu’il perd en précision nosographique ; ainsi, aujourd’hui, nous serions « tous addicts » – au sucre, au téléphone portable, au chocolat, au café, aux soldes, à la chirurgie esthétique, à Facebook, à l’amour, cette liste pouvant être continuée par chacun d’entre nous puisque nous avons tous fait, nous faisons et ferons tous, l’expérience de la force des (mauvaises habitudes, du désir, voire de la pulsion, de l’abus et de la dépendance. Notre société contemporaine semble stimuler cette expérience, en multipliant tant les objets addictogènes que les comportements addictifs : d’une part par le statut attribué aux biens sériels, d’autre part par la dimension pulsionnelle revendiquée dans les habitudes de consommation. Société du plaisir, peut-être plus hédoniste qu’épicurienne, l’époque contemporaine impose le plaisir et son désir comme nouvelle norme. Dès lors, quel est notre rapport à la pulsion, au désir compulsif, au dépassement des limites imposées aux besoins et aux envies socialement acceptables ? Comment notre société régule le désir ? Comment la politique et les médias concourent-ils à le structurer, voire à le prescrire ? Quels mécanismes à l’œuvre dans l’addiction contredisent cette prescription, et surtout : s’agit-il véritablement d’une contradiction ? Notre culture de performance et satisfaction rapides peut effectivement expliquer certaines dépendances induites par leur objet ; néanmoins, la véritable addiction mentale se nourrit d’éléments plus profondément constitutifs de l’identité de l’homme moderne et contemporain : avant tout, la fragilité des acquis, la

  4. Vaccination strategies for SIR vector-transmitted diseases.

    Science.gov (United States)

    Cruz-Pacheco, Gustavo; Esteva, Lourdes; Vargas, Cristobal

    2014-08-01

    Vector-borne diseases are one of the major public health problems in the world with the fastest spreading rate. Control measures have been focused on vector control, with poor results in most cases. Vaccines should help to reduce the diseases incidence, but vaccination strategies should also be defined. In this work, we propose a vector-transmitted SIR disease model with age-structured population subject to a vaccination program. We find an expression for the age-dependent basic reproductive number R(0), and we show that the disease-free equilibrium is locally stable for R(0) ≤ 1, and a unique endemic equilibrium exists for R(0) > 1. We apply the theoretical results to public data to evaluate vaccination strategies, immunization levels, and optimal age of vaccination for dengue disease.

  5. Digital radiograph of the middle phalanx of the third finger (MP3 region as a tool for skeletal maturity assessment

    Directory of Open Access Journals (Sweden)

    Deepa Y Hegde

    2012-01-01

    Results: The correlation determined between the MP3 stages and cervical vertebrae maturity index (CVMI stages, the peak-wise distribution of the MP3 stages, and the correlation between the MP3 stages and the chronological age were found to be highly significant. Conclusions: Digital radiograph of the MP3 region is definitely a simple, reliable, cost-effective, and time-saving technique for the assessment of skeletal maturity.

  6. CLT-koetalon lämpö- ja kosteusteknisen toiminnan analysointiraportti Q2/2014

    OpenAIRE

    Autioniemi, Juha; Pirttinen, Valtteri; Vatanen, Mikko

    2014-01-01

    CLT-koetalo-projektin yhtenä päätavoitteena on tutkia CLT-materiaalin rakennusfysikaalista toimintaa Suomen haastavissa olosuhteissa. Tämä Q2-raportti on toinen CLT-koetalon lämpö- ja kosteusteknisen toiminnan analysointiraportista, joita julkaistaan vuoden 2014 aikana yhteensä neljä. Q2/2014 -raportissa analysoidaan Kemissä sijaitsevasta CLT-koetalon rakenteista saatua mittausdataa. Koetalon rakenteissa sijaitsee yhteensä 48 mittausanturia, jotka mittaavat lämpötilaa ja suhteellista kosteutt...

  7. Impulsive vaccination and dispersal on dynamics of an SIR epidemic model with restricting infected individuals boarding transports

    Science.gov (United States)

    Jiao, Jianjun; Cai, Shaohong; Li, Limei

    2016-05-01

    To understand the effect of impulsive vaccination and restricting infected individuals boarding transports on disease spread, we establish an SIR model with impulsive vaccination, impulsive dispersal and restricting infected individuals boarding transports. This SIR epidemic model for two regions, which are connected by transportation of non-infected individuals, portrays the evolvement of diseases. We prove that all solutions of the investigated system are uniformly ultimately bounded. We also prove that there exists globally asymptotically stable infection-free boundary periodic solution. The condition for permanence is discussed. It is concluded that the approach of impulsive vaccination and restricting infected individuals boarding transports provides reliable tactic basis for preventing disease spread.

  8. Assessment of Growth Using Mandibular Canine Calcification Stages and Its Correlation with Modified MP3 Stages.

    Science.gov (United States)

    Nayak, Reshma; Nayak, Us Krishna; Hegde, Gautam

    2010-01-01

    Orthodontic diagnosis and treatment planning for growing children must involve growth prediction, especially in the treatment of skeletal problems. Studies have shown that a strong association exists between skeletal maturity and dental calcification stages. The present study was therefore taken up to provide a simple and practical method for assessing skeletal maturity using a dental periapical film and standard dental X-ray machine, to compare the developmental stages of the mandibular canine with that of developmental stages of modified MP3 and to find out if any correlation exists, to determine if the developmental stages of the mandibular canine alone can be used as a reliable indicator for assessment of skeletal maturity. A total of 160 periapical radiographs (80 males and 80 females), of the mandibular right canine and the MP3 region was taken and assessed according to the Dermirjian's stages of dental calcification and the modified MP3 stages. The correlation between the developmental stages of MP3 and the mandibular right canine in male and female groups, is of high statistical significance (p = 0.001). The correlation coefficient between MP3 stages and developmental stages of mandibular canine and chronological age in male and females was found to be not significant. The correlation between the mandibular canine calcification stages and MP3 stages was found to be significant. The developmental stages of the mandibular canine could be used very reliably as a sole indicator for assessment of skeletal maturity.

  9. Structural and aerodynamic considerations of an active piezoelectric trailing-edge tab on a helicopter rotor

    Science.gov (United States)

    Murray, Gabriel Jon

    This dissertation is concerned with an active tab for use on a rotorcraft for noise and vibration reduction. The tab is located at the trailing edge of the airfoil. The tab consists of a shim sandwiched by layers of the piezoelectric actuators, macro fiber composites, of varying length. This configuration is similar to a bimorph. The modus operandi is similar to that of a trailing edge flap. The actuators deform the tab, bending it to achieve a tip displacement. This provides a change in the lift, moment, and drag coefficients of the airfoil. By actuating the system at 3/rev to 5/rev, reductions in noise and vibration can be realized. The system was examined and designed around using the UH-60 Blackhawk as the model rotorcraft. The tab is envisioned to operate between 65% to 85% of the main rotor span. The tab's chordwise dimensions considered were 20% and 15% of the blade chord. In order to assess the potential of the tab to change the lift and moment coefficients of the airfoil-tab system, a steady computational fluid dynamics study was conducted. The results were generated via the University of Maryland's Transonic Unsteady Navier-Stokes code. Various tab deflection angles, Mach numbers, and angle-of-attack values were computed. These results were compared to a trailing edge flap of similar size. The comparison shows that the tab produces lift and moment increments similar to that of the trailing edge flap. The design of the tab---composed of both active piezoelectric actuators and passive materials---was conducted using finite element analysis. The objectives were to maximize the tip deflection due to the actuators, while minimizing the deformation due to inertial and aerodynamic forces and loads. The inertial loads (acceleration terms) come from both blade motion, such as flapping and pitch, as well as the rotation of the rotor (centrifugal force). All of these previously mentioned terms cause the tab to undergo undesirable deflections. The original concept

  10. Threshold Dynamics of a Stochastic SIR Model with Vertical Transmission and Vaccination

    Directory of Open Access Journals (Sweden)

    Anqi Miao

    2017-01-01

    Full Text Available A stochastic SIR model with vertical transmission and vaccination is proposed and investigated in this paper. The threshold dynamics are explored when the noise is small. The conditions for the extinction or persistence of infectious diseases are deduced. Our results show that large noise can lead to the extinction of infectious diseases which is conducive to epidemic diseases control.

  11. A Comparison of Skeletal Maturation assessed from MP3 and Its Correlation with Dental Maturation

    Directory of Open Access Journals (Sweden)

    Vishnu Vardhan Reddy

    2014-01-01

    Full Text Available To compare the various ossification stages of middle phalanges of third finger (MP3 and developmental stages of 2nd mandibular molar during the entire process of pubertal growth spurt. Evaluate the feasibility of recording MP3 stages using standard dental X-ray film. The mandibular 2nd molar exhibited highly significant correlation for both the males and females. This study showed a good correlation between the MP3 and dental maturity indicators. Therefore, 2nd molar tooth could be used as maturity indicator for the entire period of pubertal growth spurt. It can be used as an adjunct to the hand and wrist radiograph.

  12. Experiences with OpenMP in tmLQCD

    Energy Technology Data Exchange (ETDEWEB)

    Deuzeman, A. [Bern Univ. (Switzerland). Albert Einstein Center for Fundamental Physics; Jansen, K. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Kostrzewa, B. [Humboldt Univ. Berlin (Germany). Inst. fuer Physik; Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Urbach, C. [Bonn Univ. (Germany). HISKP (Theory); Collaboration: European Twisted Mass Collaboration

    2013-11-15

    An overview is given of the lessons learned from the introduction of multi-threading using OpenMP in tmLQCD. In particular, programming style, performance measurements, cache misses, scaling, thread distribution for hybrid codes, race conditions, the overlapping of communication and computation and the measurement and reduction of certain overheads are discussed. Performance measurements and sampling profiles are given for different implementations of the hopping matrix computational kernel.

  13. Experiences with OpenMP in tmLQCD

    International Nuclear Information System (INIS)

    Deuzeman, A.

    2013-11-01

    An overview is given of the lessons learned from the introduction of multi-threading using OpenMP in tmLQCD. In particular, programming style, performance measurements, cache misses, scaling, thread distribution for hybrid codes, race conditions, the overlapping of communication and computation and the measurement and reduction of certain overheads are discussed. Performance measurements and sampling profiles are given for different implementations of the hopping matrix computational kernel.

  14. Identifying settlements on the SIR-B images of Rimbobujang and the surrounding areas, Sumatra, Indonesia

    Directory of Open Access Journals (Sweden)

    Sutanto .

    2013-07-01

    SIR-B image proves to be a reasonably good tool to identify rural settlement in an open area, especially for that with high density of houses. Its use to identify towns and cities is more recommended.

  15. Multitasking and microtasking experience on the NA S Cray-2 and ACF Cray X-MP

    Science.gov (United States)

    Raiszadeh, Farhad

    1987-01-01

    The fast Fourier transform (FFT) kernel of the NAS benchmark program has been utilized to experiment with the multitasking library on the Cray-2 and Cray X-MP/48, and microtasking directives on the Cray X-MP. Some performance figures are shown, and the state of multitasking software is described.

  16. Development of Mixed Mode MPI / OpenMP Applications

    Directory of Open Access Journals (Sweden)

    Lorna Smith

    2001-01-01

    Full Text Available MPI / OpenMP mixed mode codes could potentially offer the most effective parallelisation strategy for an SMP cluster, as well as allowing the different characteristics of both paradigms to be exploited to give the best performance on a single SMP. This paper discusses the implementation, development and performance of mixed mode MPI / OpenMP applications. The results demonstrate that this style of programming will not always be the most effective mechanism on SMP systems and cannot be regarded as the ideal programming model for all codes. In some situations, however, significant benefit may be obtained from a mixed mode implementation. For example, benefit may be obtained if the parallel (MPI code suffers from: poor scaling with MPI processes due to load imbalance or too fine a grain problem size, memory limitations due to the use of a replicated data strategy, or a restriction on the number of MPI processes combinations. In addition, if the system has a poorly optimised or limited scaling MPI implementation then a mixed mode code may increase the code performance.

  17. Radar Precoder Design for Spectral Coexistence with Coordinated Multi-point (CoMP) System

    OpenAIRE

    Mahal, Jasmin A.; Khawar, Awais; Abdelhadi, Ahmed; Clancy, T. Charles

    2015-01-01

    This paper details the design of precoders for a MIMO radar spectrally coexistent with a MIMO cellular network. We focus on a coordinated multi-point (CoMP) system where a cluster of base stations (BSs) coordinate their transmissions to the intended user. The radar operates in two modes, interference-mitigation mode when it avoids interference with the CoMP system and cooperation mode when it exchanges information with it. Using either the conventional Switched Null Space Projection (SNSP) or...

  18. Beam transmission in MP equipment. New measurements. Main effects and application to VIVITRON

    International Nuclear Information System (INIS)

    Haas, F.; Muller, C.; Nadji, A.; Rebmeister, R.

    1989-01-01

    The MP equipment is presented and the vacuum values at different measuring points are indicated. The low energy transmission stage (foil and gas strippers) high energy stage (5, 10, and 15 micro-g/cm 2 foils and gas stripper) are described, as well as the global system. For the Vivitron, in order to reach equilibrium thickness, pression in the stripping channel should be higher than that in the MP channel, and pump power should be planned accordingly [fr

  19. Tagging b quark events in ALEPH with neural networks

    International Nuclear Information System (INIS)

    Proriol, J.; Jousset, J.; Guicheney, C.; Falvard, A.; Henrard, P.; Pallin, D.; Perret, P.; Brandl, B.

    1991-01-01

    Comparison of different methods to tag b quark events are presented: multilayered perceptron (MLP), Learning Vector Quantization (LVQ), discriminant analysis, combination of any two of the above methods. The sample events come from the ALEPH Monte Carlo and data, from the 1990 ALEPH runs. (authors) 12 refs., 16 figs., 5 tabs

  20. SIR-A views our environment An Experiment in the Batu Angkal Area, West Kalimantan, Indonesia

    Directory of Open Access Journals (Sweden)

    Sutanto .

    2013-07-01

    Factors affecting the ease of identification are. mainly tonal contrast, shape, size, surface roughness, direction in relation to the illumination, and dielectric constant. Due to the future availability of SIR-B image of Kalimantan, further study is recommended.

  1. The application of lesion sterilization and tissue repair 3Mix-MP for treating rat's dental pulp tissue

    Directory of Open Access Journals (Sweden)

    Raditya Nugroho

    2015-03-01

    Full Text Available Background: Lesion sterilization and tissue repair (LSTR 3Mix-MP are three broad-spectrum antibiotics, including metronidazole, ciprofloxacin and minocycline are mixed with propylene glycol or macrogol. There is the possibility ofthe healing process that marked proliferation ofnew blood vessels and proliferation offibroblasts in the treatment ofirreversible pulpitis by pulp capping LSTR 3MixMP because of  the principle of the method LSTR 3Mix-MP is to kill bacteria. Purpose: The purpose of this study to prove the effect of LSTR 3Mix-MP on chronic inflammation and the healing process in rat dental pulp tissue in vivo. Methods: Rattus norvegicus anaesthetized by using ketamine and xylazine dissolved in sterile isotonic saline solution (0.2 ml/50gr mm on the upper right thigh. Cavity preparation class I to perforation by using a low speed tapered diamond round bur. In the treatment group, rats were treated 3Mix-MP at a dose of10 mg and then covered with glass ionomer cement for 7 days on the pulp that has been opened for 3 days. The control group treated with saline irrigation on the pulp that has been opened for 3 days. Rats were killed after seven days, and then made preparations pulp tissue to count the number oflymphocytes, macrophages, plasma cells, blood vessels, and fibroblasts Results: There is an increase in the average number ofmacrophage cells, plasma, and fibroblasts; and decreased lymphocytes and blood vessels in the treated group exposure LSTR 3Mix-MP. Conclusion:LSTR 3Mix-MP can reduce chronic inflammation process and enhance the healing process in rat dental pulp tissue.

  2. Observation of the suppressed ADS modes $B^\\pm \\to [\\pi^\\pm K^\\mp \\pi^+\\pi^-]_D K^\\pm$ and $B^\\pm \\to [\\pi^\\pm K^\\mp \\pi^+\\pi^-]_D \\pi^\\pm$

    CERN Document Server

    INSPIRE-00258707; Abellan Beteta, C; Adeva, B; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves Jr, A A; Amato, S; Amerio, S; Amhis, Y; Anderlini, L; Anderson, J; Andreassen, R; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Bachmann, S; Back, J J; Baesso, C; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bauer, Th; Bay, A; Beddow, J; Bedeschi, F; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Benayoun, M; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M -O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bowen, E; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Burducea, I; Bursche, A; Busetto, G; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carranza-Mejia, H; Carson, L; Carvalho Akiba, K; Casse, G; Cattaneo, M; Cauet, Ch; Charles, M; Charpentier, Ph; Chen, P; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Cogneras, E; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Coquereau, S; Corti, G; Couturier, B; Cowan, G A; Craik, D; Cunliffe, S; Currie, R; D'Ambrosio, C; David, P; David, P N Y; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Oyanguren Campos, M; De Paula, L; De Silva, W; De Simone, P; Decamp, D; Deckenhoff, M; Del Buono, L; Derkach, D; Deschamps, O; Dettori, F; Di Canto, A; Dijkstra, H; Dogaru, M; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Elsby, D; Falabella, A; Färber, C; Fardell, G; Farinelli, C; Farry, S; Fave, V; Ferguson, D; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furcas, S; Furfaro, E; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garofoli, J; Garosi, P; Garra Tico, J; Garrido, L; Gaspar, C; Gauld, R; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hampson, T; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Hartmann, T; He, J; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicks, E; Hill, D; Hoballah, M; Hombach, C; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Hussain, N; Hutchcroft, D; Hynds, D; Iakovenko, V; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jans, E; Jaton, P; Jing, F; John, M; Johnson, D; Jones, C R; Jost, B; Kaballo, M; Kandybei, S; Karacson, M; Karbach, T M; Kenyon, I R; Kerzel, U; Ketel, T; Keune, A; Khanji, B; Kochebina, O; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucharczyk, M; Kudryavtsev, V; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J -P; Lefèvre, R; Leflat, A; Lefrançois, J; Leo, S; Leroy, O; Leverington, B; Li, Y; Li Gioi, L; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; von Loeben, J; Lohn, S; Lopes, J H; Lopez Asamar, E; Lopez-March, N; Lu, H; Lucchesi, D; Luisier, J; Luo, H; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Malde, S; Manca, G; Mancinelli, G; Marconi, U; Märki, R; Marks, J; Martellotti, G; Martens, A; Martin, L; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Martins Tostes, D; Massafferri, A; Matev, R; Mathe, Z; Matteuzzi, C; Maurice, E; Mazurov, A; McCarthy, J; McNulty, R; Mcnab, A; Meadows, B; Meier, F; Meissner, M; Merk, M; Milanes, D A; Minard, M -N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Morello, M J; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neufeld, N; Nguyen, A D; Nguyen, T D; Nguyen-Mau, C; Nicol, M; Niess, V; Niet, R; Nikitin, N; Nikodem, T; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Pal, B K; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perego, D L; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pessina, G; Petridis, K; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pietrzyk, B; Pilař, T; Pinci, D; Playfer, S; Plo Casasus, M; Polci, F; Polok, G; Poluektov, A; Polycarpo, E; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Redford, S; Reid, M M; dos Reis, A C; Ricciardi, S; Richards, A; Rinnert, K; Rives Molina, V; Roa Romero, D A; Robbe, P; Rodrigues, E; Rodriguez Perez, P; Roiser, S; Romanovsky, V; Romero Vidal, A; Rouvinet, J; Ruf, T; Ruffini, F; Ruiz, H; Ruiz Valls, P; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salzmann, C; Sanmartin Sedes, B; Sannino, M; Santacesaria, R; Santamarina Rios, C; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Savrina, D; Schaack, P; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M -H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Senderowska, K; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shatalov, P; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Skwarnicki, T; Smith, N A; Smith, E; Smith, M; Sokoloff, M D; Soler, F J P; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Swientek, S; Syropoulos, V; Szczekowski, M; Szczypka, P; Szumlak, T; T'Jampens, S; Teklishyn, M; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Tonelli, D; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tresch, M; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ubeda Garcia, M; Ukleja, A; Urner, D; Uwer, U; Vagnoni, V; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Vieira, D; Vilasis-Cardona, X; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; Voss, H; Waldi, R; Wallace, R; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wicht, J; Wiechczynski, J; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wishahi, J; Witek, M; Wotton, S A; Wright, S; Wu, S; Wyllie, K; Xie, Y; Xing, F; Xing, Z; Yang, Z; Young, R; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhokhov, A; Zhong, L; Zvyagin, A

    2013-01-01

    An analysis of $B^{\\pm}\\to DK^{\\pm}$ and $B^{\\pm}\\to D\\pi^{\\pm}$ decays is presented where the $D$ meson is reconstructed in the four-body final state $K^{\\pm}\\pi^{\\mp} \\pi^+ \\pi^-$. Using LHCb data corresponding to an integrated luminosity of $1.0{\\rm \\,fb}^{-1}$, first observations are made of the suppressed ADS modes $B^{\\pm}\\to [\\pi^{\\pm} K^{\\mp}\\pi^+\\pi^-]_D K^{\\pm}$ and $B^{\\pm}\\to [\\pi^{\\pm} K^{\\mp} \\pi^+\\pi^- ]_D\\pi^{\\pm}$ with a significance of $5.1\\sigma$ and greater than $10\\sigma$, respectively. Measurements of $CP$ asymmetries and $CP$-conserving ratios of partial widths from this family of decays are also performed. The magnitude of the ratio between the suppressed and favoured $B^{\\pm}\\to DK^{\\pm}$ amplitudes is determined to be $r^K_B = 0.097 \\pm{0.011}$.

  3. 6-mercaptopurine (6-MP) entrapped stealth liposomes for improvement of leukemic treatment without hepatotoxicity and nephrotoxicity.

    Science.gov (United States)

    Umrethia, Manish; Ghosh, Pradip Kumar; Majithya, Rita; Murthy, R S R

    2007-03-01

    6-mercaptopurine (6-MP) is a purine analogue used in childhood leukemia. Because of the oral bioavailability of 6-MP is low and highly variable, the aim of this study was to develop a new parenteral formulation that can prolong the biological half-life of the drug, improve its therapeutic efficacy, and its associated reduce side effects. Conventional and stealth 6-MP liposomes were prepared by a thin film hydration technique followed by a high-pressure homogenization process and characterized for percent entrapment efficiency (%EE), particle size, and stability in human plasma. Pharmacokinetic, tissue distribution, and biochemical analysis were performed after intravenous (IV) administration of all formulations of 6-MP on rats. The conventional liposomes were found less stable than stealth liposomes in human plasma at 37 degrees C. Stealth liposomes exhibited high peak plasma concentration (C(max)), and long circulating capacity in blood and biological half-life. The uptake of stealth liposomes by the liver and spleen and accumulation in the kidney were significantly less than that of conventional liposomes and the free drug. Serum urea, creatinine, GOT (Glutamic Oxaloacetic Transaminase), and GPT (Glutamic Pyruvic Transaminase) increased significantly in rats given an IV injection of conventional liposomes and the free drug, but not in those administered with the same dose of stealth liposomes. Stealth liposomes may help to increase therapeutic efficacy of 6-MP and to reduce total amount of dose as well as frequency of the dose. It also may reduce the possibility of the risk of toxicity to the liver and kidney generally associated with free 6-MP.

  4. MP3 Players: Applications and Implications for the Use of Popular Technology in Secondary Schools

    Science.gov (United States)

    Stiler, Gary M.

    2007-01-01

    This article explores potential uses for MP3 players in secondary classrooms. It presents an overview of current applications and describes an exploratory study of classroom uses. Seven high school teachers and one teacher educator participated in a three-month project to examine MP3 technology as applied to high school instruction. Their ideas…

  5. [Sir Francis Galton: the father of eugenics].

    Science.gov (United States)

    Aubert-Marson, Dominique

    2009-01-01

    Not only was Sir Francis Galton a famous geographer and statistician, he also invented "eugenics" in 1883. Eugenics, defined as the science of improving racial stock, was developed from a new heredity theory, conceived by Galton himself, and from the evolution theory of Charles Darwin, transposed to human society by Herbert Spencer. Galton's eugenics was a program to artificially produce a better human race through regulating marriage and thus procreation. Galton put particular emphasis on "positive eugenics", aimed at encouraging the physically and mentally superior members of the population to choose partners with similar traits. In 1904, he presented his ideas in front of a vast audience of physicians and scientists in London. His widely-publicized lecture served as the starting point for the development of eugenics groups in Europe and the United States during the first half of the 20th century.

  6. Especificaciones del servicio de cesación tabáquica

    Directory of Open Access Journals (Sweden)

    Mendoza A

    2016-03-01

    Full Text Available En abril de 2013, la Sociedad Española de Farmacia Familiar y Comunitaria (SEFAC presentó su propuesta sobre servicios profesionales farmacéuticos (SPF cuyo fin es cubrir las necesidades relacionadas tanto con la atención de los pacientes que utilizan medicamentos, como con la salud pública. Esta propuesta ofrece un planteamiento sobre la implantación y desarrollo de los SPF con el objetivo de impulsar su prestación por las farmacias comunitarias en los próximos años. De acuerdo con dicha propuesta todos los SPF que constituyen el catálogo de servicios contarán con un documento de especificaciones. El objeto de este documento de especificaciones, aprobado por la Junta Directiva de SEFAC el 20 de abril de 2014, es definir y caracterizar el servicio de cesación tabáquica con una doble finalidad: • Ayudar al farmacéutico comunitario y a sus representantes en el ofrecimiento, prestación, difusión, financiación y concertación de este servicio. • Servir de guía a los farmacéuticos comunitarios que desean implantar un servicio de cesación tabáquica en la farmacia o elaborar un procedimiento normalizado de trabajo para su realización. Este documento se complementa con el programa CESAR de formación en cesación tabáquica, y el Documento de intervención en Cesación tabáquica en farmacia comunitaria elaborado y avalado por SEFAC y validado por SEFAC, la Sociedad Española de Neumología y Patología Torácica (SEPAR, la Sociedad Española de Especialistas en Tabaquismo (SEDET y las sociedades médicas de atención primaria (semFYC, SEMG y SEMERGEN.

  7. Atomic orbital-based SOS-MP2 with tensor hypercontraction. I. GPU-based tensor construction and exploiting sparsity

    Energy Technology Data Exchange (ETDEWEB)

    Song, Chenchen; Martínez, Todd J. [Department of Chemistry and the PULSE Institute, Stanford University, Stanford, California 94305 (United States); SLAC National Accelerator Laboratory, Menlo Park, California 94025 (United States)

    2016-05-07

    We present a tensor hypercontracted (THC) scaled opposite spin second order Møller-Plesset perturbation theory (SOS-MP2) method. By using THC, we reduce the formal scaling of SOS-MP2 with respect to molecular size from quartic to cubic. We achieve further efficiency by exploiting sparsity in the atomic orbitals and using graphical processing units (GPUs) to accelerate integral construction and matrix multiplication. The practical scaling of GPU-accelerated atomic orbital-based THC-SOS-MP2 calculations is found to be N{sup 2.6} for reference data sets of water clusters and alanine polypeptides containing up to 1600 basis functions. The errors in correlation energy with respect to density-fitting-SOS-MP2 are less than 0.5 kcal/mol for all systems tested (up to 162 atoms).

  8. Atomic orbital-based SOS-MP2 with tensor hypercontraction. I. GPU-based tensor construction and exploiting sparsity.

    Science.gov (United States)

    Song, Chenchen; Martínez, Todd J

    2016-05-07

    We present a tensor hypercontracted (THC) scaled opposite spin second order Møller-Plesset perturbation theory (SOS-MP2) method. By using THC, we reduce the formal scaling of SOS-MP2 with respect to molecular size from quartic to cubic. We achieve further efficiency by exploiting sparsity in the atomic orbitals and using graphical processing units (GPUs) to accelerate integral construction and matrix multiplication. The practical scaling of GPU-accelerated atomic orbital-based THC-SOS-MP2 calculations is found to be N(2.6) for reference data sets of water clusters and alanine polypeptides containing up to 1600 basis functions. The errors in correlation energy with respect to density-fitting-SOS-MP2 are less than 0.5 kcal/mol for all systems tested (up to 162 atoms).

  9. Influence of heat conductivity on the performance of RTV SIR coatings with different fillers

    Energy Technology Data Exchange (ETDEWEB)

    Siderakis, K [High Voltage Laboratory, Department of Electrical and Computer Engineering, University of Patras, GR-26110 Patras (Greece); Agoris, D [High Voltage Laboratory, Department of Electrical and Computer Engineering, University of Patras, Greece, GR-26500, Rion, Greece (Greece); Gubanski, S [High Voltage Laboratory, Department of Electric Power Engineering, Chalmers University of Technology, S-41296, Gothenburg (Sweden)

    2005-10-07

    Room temperature vulcanized silicone rubber (RTV SIR) coatings are employed in order to improve the pollution performance of high voltage ceramic insulators by imparting surface hydrophobicity. In this paper, the performance of three RTV SIR coatings containing different fillers is investigated in a salt-fog test. Alumina trihydrate (ATH) and silica are the fillers included in the formulation, aiming to increase the material endurance to the energy supplied by the surface electrical activity during periods of hydrophobicity loss. The primary action of these fillers is to increase the material heat conductivity, i.e. the amount of energy conducted to the substrate. In addition, in the case of ATH relief is also achieved due to particle decomposition. The results indicate that for the compositions commercially available, where low amounts of fillers are used, and under the conditions of the test, ATH filled coatings performed better than the silica filled ones. This is attributed to ATH decomposition which further relieves the material structure and therefore decelerates material aging.

  10. Nicotinamide supplementation phenocopies SIR2 inactivation by modulating carbon metabolism and respiration during yeast chronological aging.

    Science.gov (United States)

    Orlandi, Ivan; Pellegrino Coppola, Damiano; Strippoli, Maurizio; Ronzulli, Rossella; Vai, Marina

    2017-01-01

    Nicotinamide (NAM), a form of vitamin B 3 , is a byproduct and noncompetitive inhibitor of the deacetylation reaction catalyzed by Sirtuins. These represent a family of evolutionarily conserved NAD + -dependent deacetylases that are well-known critical regulators of metabolism and aging and whose founding member is Sir2 of Saccharomyces cerevisiae. Here, we investigated the effects of NAM supplementation in the context of yeast chronological aging, the established model for studying aging of postmitotic quiescent mammalian cells. Our data show that NAM supplementation at the diauxic shift results in a phenocopy of chronologically aging sir2Δ cells. In fact, NAM-supplemented cells display the same chronological lifespan extension both in expired medium and extreme Calorie Restriction. Furthermore, NAM allows the cells to push their metabolism toward the same outcomes of sir2Δ cells by elevating the level of the acetylated Pck1. Both these cells have the same metabolic changes that concern not only anabolic pathways such as an increased gluconeogenesis but also respiratory activity in terms both of respiratory rate and state of respiration. In particular, they have a higher respiratory reserve capacity and a lower non-phosphorylating respiration that in concert with a low burden of superoxide anions can affect positively chronological aging. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  11. Ikon. iPod er kongen over mp3. Hvad er hemmeligheden?

    DEFF Research Database (Denmark)

    Dickson, Thomas

    2005-01-01

    iPod er blevet ikonet for det 21. århundrede. Men iPod var hverken den første mp3-afspiller eller den første veldesignede af slagsen. Før iPod så dagens lys var Bang & Olufsen på banen med sin næsten lige så lækre BeoSound2.......iPod er blevet ikonet for det 21. århundrede. Men iPod var hverken den første mp3-afspiller eller den første veldesignede af slagsen. Før iPod så dagens lys var Bang & Olufsen på banen med sin næsten lige så lækre BeoSound2....

  12. Multitasking domain decomposition fast Poisson solvers on the Cray Y-MP

    Science.gov (United States)

    Chan, Tony F.; Fatoohi, Rod A.

    1990-01-01

    The results of multitasking implementation of a domain decomposition fast Poisson solver on eight processors of the Cray Y-MP are presented. The object of this research is to study the performance of domain decomposition methods on a Cray supercomputer and to analyze the performance of different multitasking techniques using highly parallel algorithms. Two implementations of multitasking are considered: macrotasking (parallelism at the subroutine level) and microtasking (parallelism at the do-loop level). A conventional FFT-based fast Poisson solver is also multitasked. The results of different implementations are compared and analyzed. A speedup of over 7.4 on the Cray Y-MP running in a dedicated environment is achieved for all cases.

  13. Global analysis of multi-strains SIS, SIR and MSIR epidemic models

    OpenAIRE

    Bichara , Derdei; Iggidr , Abderrahman; Sallet , Gauthier

    2014-01-01

    International audience; We consider SIS, SIR and MSIR models with standard mass action and varying population, with $n$ different pathogen strains of an infectious disease. We also consider the same models with vertical transmission. We prove that under generic conditions a competitive exclusion principle holds. To each strain a basic reproduction ratio can be associated. It corresponds to the case where only this strain exists. The basic reproduction ratio of the complete system is the maxim...

  14. Competitive exclusion principle for SIS and SIR models with n strains

    OpenAIRE

    Bichara , Derdei; Iggidr , Abderrahman; Sallet , Gauthier

    2012-01-01

    We consider SIS and SIR models with standard mass action and varying population, with $n$ different pathogen strains of an infectious disease. We also consider the same models with vertical transmission. We prove that under generic conditions a competitive exclusion principle holds. To each strain a basic reproduction ratio can be associated. It corresponds to the case where only this strain exists. The basic reproduction ratio of the complete system is the maximum of each individual basic re...

  15. Montaigne, Sir Ralph Bankes and other English readers of the Essais.

    OpenAIRE

    O'Brien, John

    2013-01-01

    This article deals with a hitherto unknown and unpublished early modern English manuscript account of Montaigne's Essais by Sir Ralph Bankes (1631?–77) of Kingston Lacy in Dorset. Bankes's account covers a range of features in Montaigne's work: crucial elements of self-portraiture such as judgement, but also his attitude to women and doctors. These characteristics are analysed and compared first with Montaigne's own pronouncements about the aspects Bankes selects and secondly with two other s...

  16. The VLSI design of the sub-band filterbank in MP3 decoding

    Science.gov (United States)

    Liu, Jia-Xin; Luo, Li

    2018-03-01

    The sub-band filterbank is one of the most important modules which has the largest amount of calculation in MP3 decoding. In order to save CPU resources and integrate the sub-band filterbank part into MP3 IP core, the hardware circuit of the sub-band filterbank module is designed in this paper. A fast algorithm suit for hardware implementation is proposed and achieved on FPGA development board. The results show that the sub-band filterbank function is correct in the case of using very few registers and the amount of calculation and ROM resources are reduced greatly.

  17. SIR (Safe Integral Reactor) - reducing size can reduce cost

    International Nuclear Information System (INIS)

    Hayns, M.R.

    1991-01-01

    Traditional engineering economics have favoured the advantages of larger size as a means of reducing specific capital costs and hence unit generating costs. For large and small plants utilising the same concept, e.g. a small four-loop PWR vs a large four-loop PWR with the same number of components, economies of scale are well established. If, however, a smaller plant is sized to take advantage of features which are only feasible at smaller outputs, is of simpler design, with the advantage taken of the simplified design to produce the most cost-effective layout, and incorporates fewer, more easily replaceable components with minimal assembly on site, it is possible to produce a plant which is competitive with larger plant of more traditional design. When 'system' effects, such as better matching of installed capacity to the growth in demand and the fact that a smaller total capacity will be needed to meet a given demand with a specified level of confidence, are taken into account, it can be shown that a utility's overall cash-flow position can be improved with lower associated absolute financial risks. The UK/US Safe Integral Reactor (SIR) is an integral pressurized water reactor in the 300-400 MW(e) range which utilises conventional water reactor technology in a way not feasible at the very large, sizes of recent years. The SIR concept is briefly explained and its technical and economic advantages in terms of simplicity, construction, maintenance, availability, decommissioning, safety and siting described. The results of system analyses which demonstrate the overall financial advantages to a utility are presented. (author)

  18. Music-listening habits with MP3 player in a group of adolescents: a descriptive survey.

    Science.gov (United States)

    Pellegrino, E; Lorini, C; Allodi, G; Buonamici, C; Garofalo, G; Bonaccorsi, G

    2013-01-01

    Listening to music through portable MP3 players has become a very popular mode among young people and adolescents. The aim of this study is to investigate the behaviors of adolescents engaged in listening to music with MP3 player and the attendance at clubs (pubs, discotheques) where music is played at high volume. Among the 1470 students attending a secondary school in Scandicci (FI) during the school year 2009/2010, 1278 (86.9%) were at school the day of the examination and 1276 completely filled in the questionnaire. Descriptive analysis and univariate and multivariate logistic regression were performed to calculate the degree of association (OR) among the sociodemographic characteristics, listening habits and some factors identified as risky or protective as regards the possibility of developing health disorders. MP3 player users are 88.2% of the sample. Among these, a high proportion engaged behaviours that increase the risk of presenting disorders, including the exposure to high-volume (27.4%). Furthermore, 44.6% use the MP3 while driving. From the regression analysis it emerges that MP3 users showed a sort of addiction: by increasing the time and the occasions of exposure to music, they increased the volume, used maximum or medium-high volume, did not take breaks and did not decrease the volume. The study points out the spread of risky behavior in music listening, so it is necessary to better inform especially the youngsters and achieve specific preventive interventions.

  19. Evaluating anorexia-related brain atrophy using MP2RAGE-based morphometry

    International Nuclear Information System (INIS)

    Boto, Jose; Loevblad, Karl-Olof; Vargas, Maria Isabel; Gkinis, Georgios; Ortiz, Nadia; Roche, Alexis; Kober, Tobias; Marechal, Benedicte; University Hospital; Ecole Polytechnique Federale de Lausanne; Lazeyras, Francois

    2017-01-01

    To evaluate brain atrophy in anorexic patients by automated cerebral segmentation with the magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE) MRI sequence. Twenty patients (female; mean age, 27.9 years), presenting consecutively for brain MRI between August 2014-December 2016 with clinical suspicion of anorexia nervosa and BMI<18.5 kg/m 2 were included. Controls were ten healthy females (mean age, 26.5 years). Automated brain morphometry was performed based on MP2RAGE. Means of morphometric results in the two groups were compared and correlation with BMI was analysed. Significantly lower volumes of total brain, grey matter (GM), white matter (WM), cerebellum and insula were found in anorexic patients. Anorexics had higher volumes of CSF, ventricles, lateral ventricles and third ventricle. When adjusted means for weight and height were compared, the volume of WM and cerebellum were not significantly different. However, volume of WM was significantly affected by weight and positively correlated with BMI. Significant positive correlations were found between BMI and volumes of total brain, GM, cortical GM and WM. BMI was negatively correlated with volumes of CSF and third ventricle. Brain atrophy was demonstrated in anorexic patients with MP2RAGE-based automated segmentation, which seems to reliably estimate brain volume. (orig.)

  20. Evaluating anorexia-related brain atrophy using MP2RAGE-based morphometry

    Energy Technology Data Exchange (ETDEWEB)

    Boto, Jose; Loevblad, Karl-Olof; Vargas, Maria Isabel [Geneva University Hospital (Switzerland). Div. of Neuroradiology and Faculty of Medicine of Geneva; Gkinis, Georgios; Ortiz, Nadia [Geneva University Hospital (Switzerland). Dept. of Mental Health and Psychiatry; Roche, Alexis; Kober, Tobias; Marechal, Benedicte [Siemens Healthcare HC CEMEA SUI DI BM PI, Lausanne (Switzerland). Siemens ACIT, Advanced Clinical Imaging Technology; University Hospital (CHUV), Lausanne (Switzerland). Dept. of Radiology; Ecole Polytechnique Federale de Lausanne (Switzerland). LTS5; Lazeyras, Francois [Geneva University Hospital (Switzerland). Div. of Radiology and Faculty of Medicine of Geneva

    2017-12-15

    To evaluate brain atrophy in anorexic patients by automated cerebral segmentation with the magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE) MRI sequence. Twenty patients (female; mean age, 27.9 years), presenting consecutively for brain MRI between August 2014-December 2016 with clinical suspicion of anorexia nervosa and BMI<18.5 kg/m{sup 2} were included. Controls were ten healthy females (mean age, 26.5 years). Automated brain morphometry was performed based on MP2RAGE. Means of morphometric results in the two groups were compared and correlation with BMI was analysed. Significantly lower volumes of total brain, grey matter (GM), white matter (WM), cerebellum and insula were found in anorexic patients. Anorexics had higher volumes of CSF, ventricles, lateral ventricles and third ventricle. When adjusted means for weight and height were compared, the volume of WM and cerebellum were not significantly different. However, volume of WM was significantly affected by weight and positively correlated with BMI. Significant positive correlations were found between BMI and volumes of total brain, GM, cortical GM and WM. BMI was negatively correlated with volumes of CSF and third ventricle. Brain atrophy was demonstrated in anorexic patients with MP2RAGE-based automated segmentation, which seems to reliably estimate brain volume. (orig.)

  1. RaMP: A Comprehensive Relational Database of Metabolomics Pathways for Pathway Enrichment Analysis of Genes and Metabolites.

    Science.gov (United States)

    Zhang, Bofei; Hu, Senyang; Baskin, Elizabeth; Patt, Andrew; Siddiqui, Jalal K; Mathé, Ewy A

    2018-02-22

    The value of metabolomics in translational research is undeniable, and metabolomics data are increasingly generated in large cohorts. The functional interpretation of disease-associated metabolites though is difficult, and the biological mechanisms that underlie cell type or disease-specific metabolomics profiles are oftentimes unknown. To help fully exploit metabolomics data and to aid in its interpretation, analysis of metabolomics data with other complementary omics data, including transcriptomics, is helpful. To facilitate such analyses at a pathway level, we have developed RaMP (Relational database of Metabolomics Pathways), which combines biological pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG), Reactome, WikiPathways, and the Human Metabolome DataBase (HMDB). To the best of our knowledge, an off-the-shelf, public database that maps genes and metabolites to biochemical/disease pathways and can readily be integrated into other existing software is currently lacking. For consistent and comprehensive analysis, RaMP enables batch and complex queries (e.g., list all metabolites involved in glycolysis and lung cancer), can readily be integrated into pathway analysis tools, and supports pathway overrepresentation analysis given a list of genes and/or metabolites of interest. For usability, we have developed a RaMP R package (https://github.com/Mathelab/RaMP-DB), including a user-friendly RShiny web application, that supports basic simple and batch queries, pathway overrepresentation analysis given a list of genes or metabolites of interest, and network visualization of gene-metabolite relationships. The package also includes the raw database file (mysql dump), thereby providing a stand-alone downloadable framework for public use and integration with other tools. In addition, the Python code needed to recreate the database on another system is also publicly available (https://github.com/Mathelab/RaMP-BackEnd). Updates for databases in RaMP will be

  2. Investigating Environmentally Sustainable Transport Based on DALY weights and SIR Method

    Directory of Open Access Journals (Sweden)

    Hossein Nezamianpour Jahromi

    2012-09-01

    Full Text Available Accessibility is one of the main causes of well-being and growth in contemporary societies. Transportation is the backbone of accessibility systems that lead to the growth of economic and social networks and spatial dispersion of activities. Unfortunately, the adverse effects of transportation have a great impact on the natural and human environment. Since transportation is associated with fossil fuel combustion, it results in emissions of pollutants that cause damage to human health. To save the global eco-system, sustainable development has become an international priority. To deal with the sustainability of transportation systems is an important issue as testified by a growing number of initiatives framed to define and measure sustainability in transportation planning and infrastructure planning as well. The capability of environmental assessment as a sustainability instrument is well known. This study proposes a new approach to rank countries based on environmental sustainability development applying disability adjusted life year (DALY weights for transportation sector emissions. DALY weights consider actual impacts of pollutants on human health. By employing SIR method, a superiority and inferiority ranking method is presented for multiple criteria decision making, the sustainability ranking of a number of European countries is presented. Three various ranking methods extracted from SIR ranking method are discussed and the results and the correlation among them are demonstrated.

  3. Performance Tuning of x86 OpenMP Codes with MAQAO

    Science.gov (United States)

    Barthou, Denis; Charif Rubial, Andres; Jalby, William; Koliai, Souad; Valensi, Cédric

    Failing to find the best optimization sequence for a given application code can lead to compiler generated codes with poor performances or inappropriate code. It is necessary to analyze performances from the assembly generated code to improve over the compilation process. This paper presents a tool for the performance analysis of multithreaded codes (OpenMP programs support at the moment). MAQAO relies on static performance evaluation to identify compiler optimizations and assess performance of loops. It exploits static binary rewriting for reading and instrumenting object files or executables. Static binary instrumentation allows the insertion of probes at instruction level. Memory accesses can be captured to help tune the code, but such traces require to be compressed. MAQAO can analyze the results and provide hints for tuning the code. We show on some examples how this can help users improve their OpenMP applications.

  4. Dynamic Behavior for an SIRS Model with Nonlinear Incidence Rate and Treatment

    Directory of Open Access Journals (Sweden)

    Junhong Li

    2013-01-01

    Full Text Available This paper considers an SIRS model with nonlinear incidence rate and treatment. It is assumed that susceptible and infectious individuals have constant immigration rates. We investigate the existence of equilibrium and prove the global asymptotical stable results of the endemic equilibrium. We then obtained that the model undergoes a Hopf bifurcation and existences a limit cycle. Some numerical simulations are given to illustrate the analytical results.

  5. Early MIMD experience on the CRAY X-MP

    Science.gov (United States)

    Rhoades, Clifford E.; Stevens, K. G.

    1985-07-01

    This paper describes some early experience with converting four physics simulation programs to the CRAY X-MP, a current Multiple Instruction, Multiple Data (MIMD) computer consisting of two processors each with an architecture similar to that of the CRAY-1. As a multi-processor, the CRAY X-MP together with the high speed Solid-state Storage Device (SSD) in an ideal machine upon which to study MIMD algorithms for solving the equations of mathematical physics because it is fast enough to run real problems. The computer programs used in this study are all FORTRAN versions of original production codes. They range in sophistication from a one-dimensional numerical simulation of collisionless plasma to a two-dimensional hydrodynamics code with heat flow to a couple of three-dimensional fluid dynamics codes with varying degrees of viscous modeling. Early research with a dual processor configuration has shown speed-ups ranging from 1.55 to 1.98. It has been observed that a few simple extensions to FORTRAN allow a typical programmer to achieve a remarkable level of efficiency. These extensions involve the concept of memory local to a concurrent subprogram and memory common to all concurrent subprograms.

  6. Radiosynthesis and in vivo evaluation of [{sup 11}C]MP-10 as a positron emission tomography radioligand for phosphodiesterase 10A

    Energy Technology Data Exchange (ETDEWEB)

    Plisson, Christophe, E-mail: Christophe.2.plisson@gsk.com [GlaxoSmithKline, Clinical Imaging Centre Hammersmith Hospital, London, W12 0NN (United Kingdom); Salinas, Cristian [GlaxoSmithKline, Clinical Imaging Centre Hammersmith Hospital, London, W12 0NN (United Kingdom); Weinzimmer, David; Labaree, David; Lin, Shu-Fei; Ding, Yu-Shin [Yale University PET Center, Yale University School of Medicine, PO Box 208048 New Haven, CT (United States); Jakobsen, Steen [Aarhus PET Centre, Aarhus Sygehus, Norrebrogade 44, DK-8000 Aarhus C (Denmark); Smith, Paul W. [GlaxoSmithKline, Clinical Imaging Centre Hammersmith Hospital, London, W12 0NN (United Kingdom); Eiji, Kawanishi [Medicinal Chemistry Research Laboratories II, Research Division, Mitsubishi Tanabe Pharma Corporation, Saitama 335-8505 (Japan); Carson, Richard E. [Yale University PET Center, Yale University School of Medicine, PO Box 208048 New Haven, CT (United States); Gunn, Roger N.; Rabiner, Eugenii A. [GlaxoSmithKline, Clinical Imaging Centre Hammersmith Hospital, London, W12 0NN (United Kingdom)

    2011-08-15

    Introduction: The aim of this study was to evaluate a newly reported positron emission tomography (PET) radioligand [{sup 11}C]MP-10, a potent and selective inhibitor of the central phosphodiesterase 10A enzyme (PDE10A) in vivo, using PET. Methods: A procedure was developed for labeling MP-10 with carbon-11. [{sup 11}C]MP-10 was evaluated in vivo both in the pig and baboon brain. Results: Alkylation of the corresponding desmethyl compound with [{sup 11}C]methyl iodide produced [{sup 11}C]MP-10 with good radiochemical yield and specific activity. PET studies in the pig showed that [{sup 11}C]MP-10 rapidly entered the brain reaching peak tissue concentration at 1-2 min postadministration, followed by washout from the tissue. Administration of a selective PDE10A inhibitor reduced the binding in all brain regions to the levels of the cerebellum, demonstrating the saturability and selectivity of [{sup 11}C]MP-10 binding. In the nonhuman primate, the brain tissue kinetics of [{sup 11}C]MP-10 were slower, reaching peak tissue concentrations at 30-60 min postadministration. In both species, the observed rank order of regional brain signal was striatum>diencephalon>cortical regions=cerebellum, consistent with the known distribution and concentration of PDE10A. [{sup 11}C]MP-10 brain kinetics were well described by a two-tissue compartment model, and estimates of total volume of distribution (V{sub T}) were obtained. Blocking studies with unlabeled MP-10 revealed the suitability of the cerebellum as a reference tissue and enabled the estimation of regional binding potential (BP{sub ND}) as the outcome measure of specific binding. Quantification of [{sup 11}C]MP-10 binding using the simplified reference tissue model with cerebellar input function produced BP{sub ND} estimates consistent with those obtained by the two-tissue compartment model. Conclusion: We demonstrated that [{sup 11}C]MP-10 possesses good characteristics for the in vivo quantification of the PDE10A in the

  7. THC-MP: High performance numerical simulation of reactive transport and multiphase flow in porous media

    Science.gov (United States)

    Wei, Xiaohui; Li, Weishan; Tian, Hailong; Li, Hongliang; Xu, Haixiao; Xu, Tianfu

    2015-07-01

    The numerical simulation of multiphase flow and reactive transport in the porous media on complex subsurface problem is a computationally intensive application. To meet the increasingly computational requirements, this paper presents a parallel computing method and architecture. Derived from TOUGHREACT that is a well-established code for simulating subsurface multi-phase flow and reactive transport problems, we developed a high performance computing THC-MP based on massive parallel computer, which extends greatly on the computational capability for the original code. The domain decomposition method was applied to the coupled numerical computing procedure in the THC-MP. We designed the distributed data structure, implemented the data initialization and exchange between the computing nodes and the core solving module using the hybrid parallel iterative and direct solver. Numerical accuracy of the THC-MP was verified through a CO2 injection-induced reactive transport problem by comparing the results obtained from the parallel computing and sequential computing (original code). Execution efficiency and code scalability were examined through field scale carbon sequestration applications on the multicore cluster. The results demonstrate successfully the enhanced performance using the THC-MP on parallel computing facilities.

  8. Mutagenic and genotoxic activity of particulate matter MP2,5, in Pamplona, North Santander, Colombia

    Directory of Open Access Journals (Sweden)

    Martínez Montañez, Mónica Liseth

    2012-10-01

    Full Text Available Objective: To study the mutagenic and genotoxic activities of particulate material (MP2,5 collected in Pamplona, Norte de Santander, Colombia.Materials and methods: MP2,5 was monitored by means of a Partisol 2025 sequential air sampler with Plus Palmflex quartz filters. The latter were subjected to two extraction procedures: Soxhlet extraction using dichloromethane-acetone; and ultrasonic extraction using dichloromethane, acetone and dichloromethane/ acetone mix. The mutagenic and genotoxic activities were determined for each extract.Results: This is the first study conducted in Colombia that reports the mutagenic and genotoxic activities associated with particulate matter (MP2,5 taken from vehicular emissions in Pamplona, Norte de Santander. The mutagenic assay determined by the Ames test using Salmonella typhimurium strains TA98 and TA100 showed a high direct mutagenic activity in the analyzed extracts. On the other hand, the genotoxic activity, determined by means of the comet assay, was high too.Conclusion: Particulate material (MP2,5 present in air samples in Pamplona (northeastern Colombia is a risk factor for the exposed population because it can directly induce mutations and also cause genotoxic damage.

  9. A modified CoSaMP algorithm for electromagnetic imaging of two dimensional domains

    KAUST Repository

    Sandhu, Ali Imran

    2017-05-13

    The compressive sampling matching pursuit (CoSaMP) algorithm is used for solving the electromagnetic inverse scattering problem on two-dimensional sparse domains. Since the scattering matrix, which is computed by sampling the Green function, does not satisfy the restricted isometry property, a damping parameter is added to the diagonal entries of the matrix to make the CoSaMP work. The damping factor can be selected based on the level of noise in the measurements. Numerical experiments, which demonstrate the accuracy and applicability of the proposed algorithm, are presented.

  10. Lyapunov functions and global stability for SIR and SEIR models with age-dependent susceptibility

    KAUST Repository

    Korobeinikov, Andrei; Melnik, Andrey V.

    2013-01-01

    We consider global asymptotic properties for the SIR and SEIR age structured models for infectious diseases where the susceptibility depends on the age. Using the direct Lyapunov method with Volterra type Lyapunov functions, we establish conditions for the global stability of a unique endemic steady state and the infection-free steady state.

  11. Mr Gary Nairn MP, Chair of the Standing Committee on Science and Innovation, Australia

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Photos 01,04,06,07: Mr Gary Nairn MP, Chair of the Standing Committee on Science and Innovation, Australia,visiting the silicon test laboratory, April 2003. Photos 02,03: From left to right: Mr Gary Nairn MP, Chair of the Standing Committee on Science and Innovation, Australia,visiting the silicon test laboratory with Prof. Steinar Stapnes, Physicist in the ATLAS experiment, April 2003. Photos 02,09: Mrs Kerrye Nairn, Australia,visiting the silicon test laboratory, April 2003

  12. MP98, an innovative reactivity control system for LWR and VHTR, tests results on prototypes

    International Nuclear Information System (INIS)

    Emin, M.; Gagne, J.F.

    2005-01-01

    MP98' Reactivity Control System is now a technology tested on a real scale prototypes. Demonstrator is working at PWR real conditions (155 bars, 320 degree C), and many accidents configurations could be simulated. This paper presents the technology, describes the demonstrator design and presents some results. Mock up and demonstrator have permitted to optimize the design of MP98' devices to prepare industrialization. (authors)

  13. User's Guide for TOUGH2-MP - A Massively Parallel Version of the TOUGH2 Code

    International Nuclear Information System (INIS)

    Earth Sciences Division; Zhang, Keni; Zhang, Keni; Wu, Yu-Shu; Pruess, Karsten

    2008-01-01

    TOUGH2-MP is a massively parallel (MP) version of the TOUGH2 code, designed for computationally efficient parallel simulation of isothermal and nonisothermal flows of multicomponent, multiphase fluids in one, two, and three-dimensional porous and fractured media. In recent years, computational requirements have become increasingly intensive in large or highly nonlinear problems for applications in areas such as radioactive waste disposal, CO2 geological sequestration, environmental assessment and remediation, reservoir engineering, and groundwater hydrology. The primary objective of developing the parallel-simulation capability is to significantly improve the computational performance of the TOUGH2 family of codes. The particular goal for the parallel simulator is to achieve orders-of-magnitude improvement in computational time for models with ever-increasing complexity. TOUGH2-MP is designed to perform parallel simulation on multi-CPU computational platforms. An earlier version of TOUGH2-MP (V1.0) was based on the TOUGH2 Version 1.4 with EOS3, EOS9, and T2R3D modules, a software previously qualified for applications in the Yucca Mountain project, and was designed for execution on CRAY T3E and IBM SP supercomputers. The current version of TOUGH2-MP (V2.0) includes all fluid property modules of the standard version TOUGH2 V2.0. It provides computationally efficient capabilities using supercomputers, Linux clusters, or multi-core PCs, and also offers many user-friendly features. The parallel simulator inherits all process capabilities from V2.0 together with additional capabilities for handling fractured media from V1.4. This report provides a quick starting guide on how to set up and run the TOUGH2-MP program for users with a basic knowledge of running the (standard) version TOUGH2 code. The report also gives a brief technical description of the code, including a discussion of parallel methodology, code structure, as well as mathematical and numerical methods used

  14. Towards scale-independent land-surface flux estimates in Noah-MP

    Science.gov (United States)

    Thober, Stephan; Mizukami, Naoki; Samaniego, Luis; Attinger, Sabine; Clark, Martyn; Cuntz, Matthias

    2017-04-01

    Land-surface models use a variety of process representations to calculate terrestrial energy, water and biogeochemical fluxes. These process descriptions are usually derived from point measurements which are, in turn, scaled to much larger resolutions ranging from 1 km in catchment hydrology to 100 km in climate modelling. Both, hydrologic and climate models are nowadays run on different spatial resolutions, using the exactly same land surface representations. A fundamental criterion for the physical consistency of land-surface simulations across scales is that a flux estimated over a given area is independent of the spatial model resolution (i.e., the flux-matching criterion). The Noah-MP land surface model considers only one soil and land cover type per model grid cell without any representation of their subgrid variability, implying a weak flux-matching. A fractional approach simulates the subgrid variability but it requires a higher computational demand than using effective parameters and it is used only for land cover in current land surface schemes. A promising approach to derive scale-independent parameters is the Multiscale Parameter Regionalization (MPR) technique, which consists of two steps: first, it applies transfer functions directly to high-resolution data (such as 100 m soil maps) to derive high-resolution model parameter fields, acknowledging the full subgrid variability. Second, it upscales these high-resolution parameter fields to the model resolution by using appropriate upscaling operators. MPR has shown to improve substantially the scalability of the mesoscale Hydrologic Models mHM (Samaniego et al., 2010 WRR). Here, we apply the MPR technique to the Noah-MP land-surface model for a large sample of basins distributed across the contiguous USA. Specifically, we evaluate the flux-matching criterion for several hydrologic fluxes such as evapotranspiration and drainage at scales ranging from 3 km to 48 km. We investigate the impact of different

  15. MP3: a software tool for the prediction of pathogenic proteins in genomic and metagenomic data.

    Science.gov (United States)

    Gupta, Ankit; Kapil, Rohan; Dhakan, Darshan B; Sharma, Vineet K

    2014-01-01

    The identification of virulent proteins in any de-novo sequenced genome is useful in estimating its pathogenic ability and understanding the mechanism of pathogenesis. Similarly, the identification of such proteins could be valuable in comparing the metagenome of healthy and diseased individuals and estimating the proportion of pathogenic species. However, the common challenge in both the above tasks is the identification of virulent proteins since a significant proportion of genomic and metagenomic proteins are novel and yet unannotated. The currently available tools which carry out the identification of virulent proteins provide limited accuracy and cannot be used on large datasets. Therefore, we have developed an MP3 standalone tool and web server for the prediction of pathogenic proteins in both genomic and metagenomic datasets. MP3 is developed using an integrated Support Vector Machine (SVM) and Hidden Markov Model (HMM) approach to carry out highly fast, sensitive and accurate prediction of pathogenic proteins. It displayed Sensitivity, Specificity, MCC and accuracy values of 92%, 100%, 0.92 and 96%, respectively, on blind dataset constructed using complete proteins. On the two metagenomic blind datasets (Blind A: 51-100 amino acids and Blind B: 30-50 amino acids), it displayed Sensitivity, Specificity, MCC and accuracy values of 82.39%, 97.86%, 0.80 and 89.32% for Blind A and 71.60%, 94.48%, 0.67 and 81.86% for Blind B, respectively. In addition, the performance of MP3 was validated on selected bacterial genomic and real metagenomic datasets. To our knowledge, MP3 is the only program that specializes in fast and accurate identification of partial pathogenic proteins predicted from short (100-150 bp) metagenomic reads and also performs exceptionally well on complete protein sequences. MP3 is publicly available at http://metagenomics.iiserb.ac.in/mp3/index.php.

  16. Determination of the Geographical Origin of All Commercial Hake Species by Stable Isotope Ratio (SIR) Analysis.

    Science.gov (United States)

    Carrera, Mónica; Gallardo, José M

    2017-02-08

    The determination of the geographical origin of food products is relevant to comply with the legal regulations of traceability, to avoid food fraud, and to guarantee food quality and safety to the consumers. For these reasons, stable isotope ratio (SIR) analysis using an isotope ratio mass spectrometry (IRMS) instrument is one of the most useful techniques for evaluating food traceability and authenticity. The present study was aimed to determine, for the first time, the geographical origin for all commercial fish species belonging to the Merlucciidae family using SIR analysis of carbon (δ 13 C) and nitrogen (δ 15 N). The specific results enabled their clear classification according to the FAO (Food and Agriculture Organization of the United Nations) fishing areas, latitude, and geographical origin in the following six different clusters: European, North African, South African, North American, South American, and Australian hake species.

  17. Positron-emitting resin microspheres as surrogates of 90Y SIR-Spheres: a radiolabeling and stability study

    International Nuclear Information System (INIS)

    Avila-Rodriguez, Miguel A.; Selwyn, Reed G.; Hampel, Joseph A.; Thomadsen, Bruce R.; DeJesus, Onofre T.; Converse, Alexander K.; Nickles, Robert J.

    2007-01-01

    Commercially available resin microspheres and SIR-Spheres were labeled with metallic positron emitters and evaluated as positron emission tomography (PET) imaging surrogates of 90 Y SIR-Spheres. Radiolabeling was performed using a batch method, and in vitro stability over 24 h was evaluated in saline at physiological pH at 37 o C. The activity per microsphere distribution, as evaluated by autoradiography, showed the activity per microsphere to be proportional to the square radius of the spheres, suggesting surface binding. The in vivo stability of radiolabeling was evaluated in rats by micro-PET imaging after the intravenous injection of labeled microspheres. The different resin microspheres and radionuclides evaluated in this study all showed good radiolabeling efficiency and in vitro stability. However, only resins labeled with 86 Y and 89 Zr proved to have the in vivo stability required for clinical applications

  18. MP-4 Contributes to Snake Venom Neutralization by Mucuna pruriens Seeds through an Indirect Antibody-mediated Mechanism*

    Science.gov (United States)

    Kumar, Ashish; Gupta, Chitra; Salunke, Dinakar M.

    2016-01-01

    Mortality due to snakebite is a serious public health problem, and available therapeutics are known to induce debilitating side effects. Traditional medicine suggests that seeds of Mucuna pruriens can provide protection against the effects of snakebite. Our aim is to identify the protein(s) that may be important for snake venom neutralization and elucidate its mechanism of action. To this end, we have identified and purified a protein from M. pruriens, which we have named MP-4. The full-length polypeptide sequence of MP-4 was obtained through N-terminal sequencing of peptide fragments. Sequence analysis suggested that the protein may belong to the Kunitz-type protease inhibitor family and therefore may potentially neutralize the proteases present in snake venom. Using various structural and biochemical tools coupled with in vivo assays, we are able to show that MP-4 does not afford direct protection against snake venom because it is actually a poor inhibitor of serine proteases. Further experiments showed that antibodies generated against MP-4 cross-react with the whole venom and provide protection to mice against Echis carinatus snake venom. This study shows that the MP-4 contributes significantly to the snake venom neutralization activity of M. pruriens seeds through an indirect antibody-mediated mechanism. PMID:26987900

  19. The threshold of a stochastic delayed SIR epidemic model with temporary immunity

    Science.gov (United States)

    Liu, Qun; Chen, Qingmei; Jiang, Daqing

    2016-05-01

    This paper is concerned with the asymptotic properties of a stochastic delayed SIR epidemic model with temporary immunity. Sufficient conditions for extinction and persistence in the mean of the epidemic are established. The threshold between persistence in the mean and extinction of the epidemic is obtained. Compared with the corresponding deterministic model, the threshold affected by the white noise is smaller than the basic reproduction number R0 of the deterministic system.

  20. Sir Winston Churchill: treatment for pneumonia in 1943 and 1944.

    Science.gov (United States)

    Vale, J A; Scadding, J W

    2017-12-01

    This paper reviews Churchill's illnesses in February 1943 and August/September 1944 when he developed pneumonia; on the first occasion this followed a cold and sore throat. Churchill was managed at home by Sir Charles Wilson (later Lord Moran) with the assistance of two nurses and the expert advice of Dr Geoffrey Marshall, Brigadier Lionel Whitby and Colonel Robert Drew. A sulphonamide (sulphathiazole on the first occasion) was prescribed for both illnesses. Churchill recovered, and despite his illnesses continued to direct the affairs of State from his bed. On the second occasion, Churchill's illness was not made public.

  1. Incremental diagnostic value of targeted biopsy using mpMRI-TRUS fusion versus 14-fragments prostatic biopsy. A prospective controlled study

    International Nuclear Information System (INIS)

    Mariotti, Guilherme C.; Falsarella, Priscila M.; Garcia, Rodrigo G.; Queiroz, Marcos R.G.; Lemos, Gustavo C.; Baroni, Ronaldo H.

    2018-01-01

    To compare the incremental diagnostic value of targeted biopsy using real-time multiparametric magnetic resonance imaging and transrectal ultrasound (mpMRI-TRUS) fusion to conventional 14-cores biopsy. Uni-institutional, institutional review board (IRB) approved prospective blinded study comparing TRUS-guided random and targeted biopsy using mpMRI-TRUS fusion, in 100 consecutive men. We included men with clinical-laboratorial suspicious for prostate cancer and Likert score ≥ 3 mp-MRI. Patients previously diagnosed with prostate cancer were excluded. All patients were submitted to 14-cores TRUS-guided biopsy (mpMRI data operator-blinded), followed by targeted biopsy using mpMRI-TRUS fusion. There was an overall increase in cancer detection rate, from 56% with random technique to 62% combining targeted biopsy using mpMRI-TRUS fusion; incremental diagnosis was even more relevant for clinically significant lesions (Gleason ≥ 7), diagnosing 10% more clinically significant lesions with fusion biopsy technique. Diagnosis upgrade occurred in 5 patients that would have negative results in random biopsies and had clinically significant tumours with the combined technique, and in 5 patients who had the diagnosis of significant tumours after fusion biopsy and clinically insignificant tumours in random biopsies(p=0.0010). Targeted biopsy using mpMRI-TRUS fusion has incremental diagnostic value in comparison to conventional random biopsy, better detecting clinically significant prostate cancers. (orig.)

  2. Incremental diagnostic value of targeted biopsy using mpMRI-TRUS fusion versus 14-fragments prostatic biopsy. A prospective controlled study

    Energy Technology Data Exchange (ETDEWEB)

    Mariotti, Guilherme C.; Falsarella, Priscila M.; Garcia, Rodrigo G.; Queiroz, Marcos R.G. [Hospital Israelita Albert Einstein, Department of Interventional Radiology, Sao Paulo (Brazil); Lemos, Gustavo C. [Hospital Israelita Albert Einstein, Department of Urology, Sao Paulo (Brazil); Baroni, Ronaldo H. [Hospital Israelita Albert Einstein, Department of Radiology, Sao Paulo (Brazil)

    2018-01-15

    To compare the incremental diagnostic value of targeted biopsy using real-time multiparametric magnetic resonance imaging and transrectal ultrasound (mpMRI-TRUS) fusion to conventional 14-cores biopsy. Uni-institutional, institutional review board (IRB) approved prospective blinded study comparing TRUS-guided random and targeted biopsy using mpMRI-TRUS fusion, in 100 consecutive men. We included men with clinical-laboratorial suspicious for prostate cancer and Likert score ≥ 3 mp-MRI. Patients previously diagnosed with prostate cancer were excluded. All patients were submitted to 14-cores TRUS-guided biopsy (mpMRI data operator-blinded), followed by targeted biopsy using mpMRI-TRUS fusion. There was an overall increase in cancer detection rate, from 56% with random technique to 62% combining targeted biopsy using mpMRI-TRUS fusion; incremental diagnosis was even more relevant for clinically significant lesions (Gleason ≥ 7), diagnosing 10% more clinically significant lesions with fusion biopsy technique. Diagnosis upgrade occurred in 5 patients that would have negative results in random biopsies and had clinically significant tumours with the combined technique, and in 5 patients who had the diagnosis of significant tumours after fusion biopsy and clinically insignificant tumours in random biopsies(p=0.0010). Targeted biopsy using mpMRI-TRUS fusion has incremental diagnostic value in comparison to conventional random biopsy, better detecting clinically significant prostate cancers. (orig.)

  3. Deteriorated stress response in stationary-phase yeast: Sir2 and Yap1 are essential for Hsf1 activation by heat shock and oxidative stress, respectively.

    Directory of Open Access Journals (Sweden)

    Inbal Nussbaum

    Full Text Available Stationary-phase cultures have been used as an important model of aging, a complex process involving multiple pathways and signaling networks. However, the molecular processes underlying stress response of non-dividing cells are poorly understood, although deteriorated stress response is one of the hallmarks of aging. The budding yeast Saccharomyces cerevisiae is a valuable model organism to study the genetics of aging, because yeast ages within days and are amenable to genetic manipulations. As a unicellular organism, yeast has evolved robust systems to respond to environmental challenges. This response is orchestrated largely by the conserved transcription factor Hsf1, which in S. cerevisiae regulates expression of multiple genes in response to diverse stresses. Here we demonstrate that Hsf1 response to heat shock and oxidative stress deteriorates during yeast transition from exponential growth to stationary-phase, whereas Hsf1 activation by glucose starvation is maintained. Overexpressing Hsf1 does not significantly improve heat shock response, indicating that Hsf1 dwindling is not the major cause for Hsf1 attenuated response in stationary-phase yeast. Rather, factors that participate in Hsf1 activation appear to be compromised. We uncover two factors, Yap1 and Sir2, which discretely function in Hsf1 activation by oxidative stress and heat shock. In Δyap1 mutant, Hsf1 does not respond to oxidative stress, while in Δsir2 mutant, Hsf1 does not respond to heat shock. Moreover, excess Sir2 mimics the heat shock response. This role of the NAD+-dependent Sir2 is supported by our finding that supplementing NAD+ precursors improves Hsf1 heat shock response in stationary-phase yeast, especially when combined with expression of excess Sir2. Finally, the combination of excess Hsf1, excess Sir2 and NAD+ precursors rejuvenates the heat shock response.

  4. Deteriorated stress response in stationary-phase yeast: Sir2 and Yap1 are essential for Hsf1 activation by heat shock and oxidative stress, respectively.

    Science.gov (United States)

    Nussbaum, Inbal; Weindling, Esther; Jubran, Ritta; Cohen, Aviv; Bar-Nun, Shoshana

    2014-01-01

    Stationary-phase cultures have been used as an important model of aging, a complex process involving multiple pathways and signaling networks. However, the molecular processes underlying stress response of non-dividing cells are poorly understood, although deteriorated stress response is one of the hallmarks of aging. The budding yeast Saccharomyces cerevisiae is a valuable model organism to study the genetics of aging, because yeast ages within days and are amenable to genetic manipulations. As a unicellular organism, yeast has evolved robust systems to respond to environmental challenges. This response is orchestrated largely by the conserved transcription factor Hsf1, which in S. cerevisiae regulates expression of multiple genes in response to diverse stresses. Here we demonstrate that Hsf1 response to heat shock and oxidative stress deteriorates during yeast transition from exponential growth to stationary-phase, whereas Hsf1 activation by glucose starvation is maintained. Overexpressing Hsf1 does not significantly improve heat shock response, indicating that Hsf1 dwindling is not the major cause for Hsf1 attenuated response in stationary-phase yeast. Rather, factors that participate in Hsf1 activation appear to be compromised. We uncover two factors, Yap1 and Sir2, which discretely function in Hsf1 activation by oxidative stress and heat shock. In Δyap1 mutant, Hsf1 does not respond to oxidative stress, while in Δsir2 mutant, Hsf1 does not respond to heat shock. Moreover, excess Sir2 mimics the heat shock response. This role of the NAD+-dependent Sir2 is supported by our finding that supplementing NAD+ precursors improves Hsf1 heat shock response in stationary-phase yeast, especially when combined with expression of excess Sir2. Finally, the combination of excess Hsf1, excess Sir2 and NAD+ precursors rejuvenates the heat shock response.

  5. The influence of percutaneous nephrolithotomy on human systemic stress response, SIRS and renal function.

    Science.gov (United States)

    Shen, Pengfei; Wei, Wuran; Yang, Xiaochun; Zeng, Hao; Li, Xiong; Yang, Jie; Wang, Jia; Huang, Jiaoti

    2010-10-01

    The objective of this study is to investigate the influences of percutaneous nephrolithotomy (PNL) and open surgery nephrolithotomy on the systemic stress response, SIRS and renal function. Forty patients with kidney calculi were enrolled in the study. Twenty cases were randomized to the PNL group and the other twenty cases to the open surgery group. Levels of C-reactive protein (CRP), interleukin-6(IL-6), β(2)-microglobulin (β(2)-MG), respiration rate, heart rate, body temperature and white blood cell counts were examined. CRP and IL-6 were measured in all patients pre-operatively and on post-operative days 1, 3 and 6, respectively. There was significant difference in their pre- and post-operation levels (P PNL group and 12 cases in open surgery group; there was significant difference between the two groups (P 0.05). Urine β(2)-MG levels were also measured. There was significant difference between pre- and the first day post-PNL (P PNL (P > 0.05). There was significant difference between pre- and first and third day post-open surgery (P 0.05). There was significant difference between two groups at the first, third and sixth days (P PNL group and open surgery group to some extent. The degree of stress response of PNL is lower than that of open surgery, proving the advantages of PNL with reference to serum immunology. There were cases in both the groups with SIRS, but the degree of SIRS in PNL group was lesser than the other group. Both the groups have no obvious effect on glomerular filtration function after operation and have effect on renal tubular reabsorption in the early stage after operation; but the recovery of the PNL group is faster than the open surgery group. It is thus shown that PNL is much safer and more feasible and has lesser effect on renal function.

  6. Medicinal use of earths and minerals from Hippocrates to Sir Hans Sloane and beyond.

    Science.gov (United States)

    Retsas, Spyros

    2012-12-01

    In 1931 two pharmaceutical drawers containing mineral specimens, belonging to Sir Hans Sloane, the 18th century collector, Royal Physician, President of the Royal Society and of the Royal College of Physicians of London, were found in the Department of Botany of the Natural History Museum (NHM) of London. The drawers, each divided into 49 compartments, contained a total of 107 mineral pharmaceutical specimens, some labelled as mercury or white arsenic. Their registration, identification with the Sloane Manuscript Catalogues and subsequent transfer to the Mineralogy department of the NHM where one of these drawers is now on public display, had been documented by 1935. In antiquity therapeutic empiricism attributed medicinal properties to animal products, plants and minerals, including the soil of specific geographic locations. This communication traces the medicinal use of certain earths and minerals, listed in Sir Hans Sloane's manuscript catalogues, to classical antiquity with a reference to Arsenic compounds, which in our time are finding application in the treatment of acute promyelocytic leukaemia and to Terra Lemnia, a celebrated antidote of repute spanning twenty centuries, also included in the Sloane collections.

  7. Mitos y tabúes en la sexualidad humana

    Directory of Open Access Journals (Sweden)

    Ignacio González Labrador

    2002-06-01

    Full Text Available Se realizan consideraciones muy generales sobre el origen de los géneros y cómo esta formación favorece la presencia de mitos y tabúes en la expresión de la sexualidad de la pareja humana.Very general considerations are presented on the origin of genders and how this formation has favored myths and taboos in the expression of the human couple's sexuality.

  8. Photovoltaic sheathing element with one or more tabs

    Energy Technology Data Exchange (ETDEWEB)

    Keenihan, James R; Langmaid, Joseph A; Lopez, Leonardo C.

    2017-02-07

    The present invention is premised upon an assembly that includes at least a photovoltaic sheathing element capable of being affixed on a building structure. The shingle including at least a photovoltaic cell assembly, a body portion attached to one or more portions of the photovoltaic cell assembly. Wherein the body portion includes one or more top peripheral tabs each capable of fitting under one or more vertically adjoining devices.

  9. Mutagenic and genotoxic activity of particulate matter MP2,5, in Pamplona, North Santander, Colombia

    OpenAIRE

    Martínez Montañez, Mónica Liseth; Meléndez Gélvez, Iván; Quijano Parra, Alfonso

    2012-01-01

    Objective: To study the mutagenic and genotoxic activities of particulate material (MP2,5 collected in Pamplona, Norte de Santander, Colombia.Materials and methods: MP2,5 was monitored by means of a Partisol 2025 sequential air sampler with Plus Palmflex quartz filters. The latter were subjected to two extraction procedures: Soxhlet extraction using dichloromethane-acetone; and ultrasonic extraction using dichloromethane, acetone and dichloromethane/ acetone mix. The mutagenic and genotoxic a...

  10. Rhizosphere competent Mesorhizobiumloti MP6 induces root hair curling, inhibits Sclerotinia sclerotiorum and enhances growth of Indian mustard (Brassica campestris Mesorhizobium loti MP6 rizosférico competente induz encurvamento do pelo daraiz, inibe Sclerotinia sclerotiorum e estimula o crescimento de mostarda indiana (Brassica campestris

    Directory of Open Access Journals (Sweden)

    Shikha Chandra

    2007-03-01

    Full Text Available The bacterial strain Mesorhizobium loti MP6, isolated from root nodules of Mimosa pudica induced growth and yield of Brassica campestris. The isolate MP6 secreted hydroxamate type siderophore in Chrom-Azurol Siderophore (CAS agar medium. Production of hydrocyanic acid (HCN, indole acetic acid (IAA and phosphate solubilizing ability was also recorded under normal growth conditions. Root hair curling was observed through simple glass-slide technique. In vitro study showed a significant increase in population of M. loti MP6 in rhizosphere due to root exudates of B. campestris. In dual culture technique the strain showed a strong antagonistic effect against Sclerotinia sclerotiorum, a white rot pathogen of Brassica campestris. The growth of S. sclerotiorum was inhibited by 75% after prolonged incubation. Efficient root colonization of mustard seedlings was confirmed by using a streptomycin-resistant marker M. loti MP6strep+. The M. loti MP6 coated seeds proved enhanced seed germination, early vegetative growth and grain yield as compared to control. Also, a drastic decline (99% in the incidence of white rot was observed due to application of M. loti MP6.A cepa bacteriana Mesorhizobium loti MP6 isolada de nódulos de raiz de Mimosa pudica induziu o crescimento e o rendimento de Brassica campestris. A cepa MP6 secretou sideróforo do tipo hidroxamato em meio sólido Chrom-Azurol Siderophore (CAS. Em condições normais de crescimento, a cepa foi também capaz de produzir de ácido cianídrico (HCN e acido indolacético (AIA e solubilizar fosfato. O encurvamento do pelo da raiz foi observado usando a simples técnica de lâmina e lamínula. Estudos in vitro mostraram um aumento significativo na população de M. loti MP6 na rizosfera devido aos exsudatos de B. campestris. Empregando-se técnica de co-cultura, a cepa mostrou um grande efeito antagônico contra o fungo Sclerotinia sclerotiorum, o patógeno da podridão branca de Brassica campestris. Ap

  11. MP.EXE Microphone pressure sensitivity calibration calculation program

    DEFF Research Database (Denmark)

    Rasmussen, Knud

    1999-01-01

    MP.EXE is a program which calculates the pressure sensitivity of LS1 microphones as defined in IEC 61094-1, based on measurement results performed as laid down in IEC 61094-2.A very early program was developed and written by K. Rasmussen. The code of the present heavily extended version is writte...... by E.S. Olsen.The present manual is written by K.Rasmussen and E.S. Olsen....

  12. The Threshold of a Stochastic SIRS Model with Vertical Transmission and Saturated Incidence

    Directory of Open Access Journals (Sweden)

    Chunjuan Zhu

    2017-01-01

    Full Text Available The threshold of a stochastic SIRS model with vertical transmission and saturated incidence is investigated. If the noise is small, it is shown that the threshold of the stochastic system determines the extinction and persistence of the epidemic. In addition, we find that if the noise is large, the epidemic still prevails. Finally, numerical simulations are given to illustrate the results.

  13. Traveling waves in a delayed SIR model with nonlocal dispersal and nonlinear incidence

    Science.gov (United States)

    Zhang, Shou-Peng; Yang, Yun-Rui; Zhou, Yong-Hui

    2018-01-01

    This paper is concerned with traveling waves of a delayed SIR model with nonlocal dispersal and a general nonlinear incidence. The existence and nonexistence of traveling waves of the system are established respectively by Schauder's fixed point theorem and two-sided Laplace transform. It is also shown that the spread speed c is influenced by the dispersal rate of the infected individuals and the delay τ.

  14. Evaluation of the performance of MP4-based procedures for a wide range of thermochemical and kinetic properties

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Li-Juan; Wan, Wenchao; Karton, Amir, E-mail: amir.karton@uwa.edu.au

    2016-11-30

    We evaluate the performance of standard and modified MPn procedures for a wide set of thermochemical and kinetic properties, including atomization energies, structural isomerization energies, conformational energies, and reaction barrier heights. The reference data are obtained at the CCSD(T)/CBS level by means of the Wn thermochemical protocols. We find that none of the MPn-based procedures show acceptable performance for the challenging W4-11 and BH76 databases. For the other thermochemical/kinetic databases, the MP2.5 and MP3.5 procedures provide the most attractive accuracy-to-computational cost ratios. The MP2.5 procedure results in a weighted-total-root-mean-square deviation (WTRMSD) of 3.4 kJ/mol, whilst the computationally more expensive MP3.5 procedure results in a WTRMSD of 1.9 kJ/mol (the same WTRMSD obtained for the CCSD(T) method in conjunction with a triple-zeta basis set). We also assess the performance of the computationally economical CCSD(T)/CBS(MP2) method, which provides the best overall performance for all the considered databases, including W4-11 and BH76.

  15. Early MIMD experience with a plasma physics simulation program on the CRAY X-MP

    International Nuclear Information System (INIS)

    Rhoades, C.E. Jr.

    1986-02-01

    This paper describes some early experience with converting a plasma physics simulation program to the CRAY X-MP, a current multiple instruction, multiple data (MIMD) computer consisting of two processors with architecture similar to that of the CRAY-1. The computer program used in this study is an all Fortran version of SELF, a two species, one space, two velocity, electromagnetic, Newtonian, particle in cell, plasma simulation code. The approach to converting SELF to use both processors of the CRAY X-MP is described in some detail. The resulting multiprocessor version of SELF is nearly a factor of two faster in real time than the single processor version. The multiprocessor version obtains 58.2+-.1 seconds of central processor time in 30+-.5 seconds of real time. For comparison, the CRAY-1 execution time if 74.5 seconds. For SELF, which is mostly scalar coding, the CRAY X-MP is about 2.5 times faster overall than the CRAY-1

  16. Early Response Roles for Prolactin Cortisol and Circulating and Cellular Levels of Heat Shock Proteins 72 and 90α in Severe Sepsis and SIRS

    Directory of Open Access Journals (Sweden)

    K. Vardas

    2014-01-01

    Full Text Available Objective. To evaluate the early heat shock protein (HSP and hormonal stress response of intensive care unit (ICU patients with severe sepsis/septic shock (SS or systemic inflammatory response syndrome (SIRS compared to healthy subjects (H. Methods. Patients with early (first 48 hrs SS (n=29 or SIRS (n=29 admitted to a university ICU and 16 H were enrolled in the study. Serum prolactin, cortisol, and plasma ACTH were determined using immunoassay analyzers. ELISA was used to evaluate extracellular HSPs (eHSP90α, eHSP72 and interleukins. Mean fluorescence intensity (MFI values for intracellular HSPs (iHSP72, iHSP90α were measured using 4-colour flow-cytometry. Results. Prolactin, cortisol, and eHSP90α levels were significantly increased in SS patients compared to SIRS and H (P<0.003. ACTH and eHSP72 were significantly higher in SS and SIRS compared to H (P<0.005. SS monocytes expressed lower iHSP72 MFI levels compared to H (P=0.03. Prolactin was related with SAPS III and APACHE II scores and cortisol with eHSP90α, IL-6, and lactate (P<0.05. In SS and SIRS eHSP90α was related with eHSP72, IL-6, and IL-10. Conclusion. Prolactin, apart from cortisol, may have a role in the acute stress response in severe sepsis. In this early-onset inflammatory process, cortisol relates to eHSP90α, monocytes suppress iHSP72, and plasma eHSP72 increases.

  17. Caracterização do material particulado atmosférico (MP1,0 e MP 2,5) quanto ao conteúdo iônico inorgânico em ambientes aberto e fechado

    OpenAIRE

    Flávia Augusta Marquezini

    2012-01-01

    Amostras de material particulado atmosférico fino (MP2,5 e MP1,0) foram coletadas em Londrina/PR e Assis/SP e analisadas com o objetivo de investigar a correlação existente entre espécies iônicas solúveis provenientes de fontes antrópicas (nitrato e sulfato). Íons secundários como cloreto, nitrato e sulfato foram medidos utilizando a cromatografia de íons. As razões NO3-/SO42- foram determinadas para os locais amostrados. No ambiente fechado impactado por frota veicular utilizando etanol/gaso...

  18. Investigation on solder joint strength of nickel tin-plated and CRS tabs with PCB

    International Nuclear Information System (INIS)

    Luay Hussain

    2002-01-01

    Failure analysis on easily peels off Nickel and CRS steel tabs from PCB was carried out. Nickel Tin plated tabs, CRS steel tabs and tube were joined to the PCB using reflow/ convection soldering, in an oven. The solder paste composition is Sn36/Pb35/Ag2. Peel test was conducted and it was found that many tabs could be easily peeled off with low force. Porosities which varies from 0.4 mm to < 0.01mm in diameter, developed during soldering process and solidification was noted. It was found, the number, size and position of these porosities inside the solder layer on both parts of the tabs affect the peel strength. Scanning Electron Microscopy study and EDX analysis were carried out. It was found that the low peel strength values were due to the combination of generation and development of porosities during soldering process which act as stress concentrators and the evolution (growth) of eutectic Sn/Pb and Sn/Ni/Cu brittle grainy phase. Large eutectic microstructure with brittle Sn-Ni-Cu grainy phase enhances the failure with low peeling forces. Sample showing no feature of Sn/Ni/Cu grain gave high peeling strength value. Solder reflow, an important process, can result in strength enhancement (if it was controlled for example in a furnace). (Author)

  19. INES: The International Nuclear Event Scale user's manual

    International Nuclear Information System (INIS)

    1992-09-01

    The revised and extended addition of the International Nuclear Event Scale is presented. The manual is comprised of four parts. Part 1 contains a summary of the basis of the scale and of the procedure to be used for rating events. Part 2 contains the detailed guidance required to rate events in terms of off-site and on-site impact. These two parts are applicable to all nuclear facilities. Parts 3 and 4 contain the detailed guidance required to rate events in terms of defence in depth for reactors and other facilities, respectively. 5 figs, 2 tabs

  20. A new system for assessment of growth using mandibular canine calcification stages and its correlation with modified MP3 stages.

    Science.gov (United States)

    Hegde, Gautham; Hegde, Nanditha; Kumar, Anil; Keshavaraj

    2014-07-01

    Orthodontic diagnosis and treatment planning for growing children must involve growth prediction, especially in the treatment of skeletal problems. Studies have shown that a strong association exists between skeletal maturity and dental calcification stages. The present study was therefore taken up to provide a simple and practical method for assessing skeletal maturity using a dental periapical film and standard dental X-ray machine, to compare the developmental stages of the mandibular canine with that of developmental stages of modified MP3 and to find out if any correlation exists, to determine if the developmental stages of the mandibular canine alone can be used as a reliable indicator for assessment of skeletal maturity. A total of 160 periapical radiographs, of the mandibular right canine and the MP3 region was taken and assessed according to the Dermirjian's stages of dental calcification and the modified MP3 stages. The correlation coefficient between MP3 stages and developmental stages of mandibular canine was found to be significant in both male and female groups. When the canine calcification stages were compared with the MP3 stages it was found that with the exception of the D stage of canine calcification the remaining stages showed a very high correlation with the modified MP3 stages. The correlation between the mandibular canine calcification stages, and the MP3 stages was found to be significant. The canine calcification could be used as a sole indicator for assessment of skeletal maturity.

  1. The threshold of a stochastic delayed SIR epidemic model with vaccination

    Science.gov (United States)

    Liu, Qun; Jiang, Daqing

    2016-11-01

    In this paper, we study the threshold dynamics of a stochastic delayed SIR epidemic model with vaccination. We obtain sufficient conditions for extinction and persistence in the mean of the epidemic. The threshold between persistence in the mean and extinction of the stochastic system is also obtained. Compared with the corresponding deterministic model, the threshold affected by the white noise is smaller than the basic reproduction number Rbar0 of the deterministic system. Results show that time delay has important effects on the persistence and extinction of the epidemic.

  2. Shelf life of irradiated minimally processed (MP) watercress (Nasturtium officinale)

    International Nuclear Information System (INIS)

    Martins, C.G.; Behrens, J.H.; Aragon-Alegro, L.C.; Vieira, V.S.; Costa-Sobrinho, P.S.; Vizeu, D.M.; Hutzler, B.; Franco, B.D.G. de M.; Destro, M.T.; Landgraf, M.

    2007-01-01

    This study was carried out to evaluate the shelf life of minimally processed (MP) watercress exposed to gamma radiation with doses of 1.0; 3.0; 4.0 kGy. Packaged irradiated and non-irradiated MP watercress was subject to sensory analysis. A panel consisting of 25-30 non-trained members, aged 20-55 years, was used. Sensory evaluation was carried out on days 0, 2, 5, 7, 9 and 12 after treatment with packages maintained at 7 °C. The members of the panel rated each sample for overall liking on a hybrid 10 hedonic scale (0 = extremely dislike; 10 = extremely like). Microbiological analyses were also conducted. Compared to the non-irradiated sample, 1 kGy irradiated watercress increased its shelf life by one day (16 days). Shelf lives of samples exposed to higher doses were reduced to 9 days (3 kGy) and 6 days (4 kGy) due to changes in appearance. The microbiological quality was good throughout the experiment

  3. MP-4 Contributes to Snake Venom Neutralization by Mucuna pruriens Seeds through an Indirect Antibody-mediated Mechanism.

    Science.gov (United States)

    Kumar, Ashish; Gupta, Chitra; Nair, Deepak T; Salunke, Dinakar M

    2016-05-20

    Mortality due to snakebite is a serious public health problem, and available therapeutics are known to induce debilitating side effects. Traditional medicine suggests that seeds of Mucuna pruriens can provide protection against the effects of snakebite. Our aim is to identify the protein(s) that may be important for snake venom neutralization and elucidate its mechanism of action. To this end, we have identified and purified a protein from M. pruriens, which we have named MP-4. The full-length polypeptide sequence of MP-4 was obtained through N-terminal sequencing of peptide fragments. Sequence analysis suggested that the protein may belong to the Kunitz-type protease inhibitor family and therefore may potentially neutralize the proteases present in snake venom. Using various structural and biochemical tools coupled with in vivo assays, we are able to show that MP-4 does not afford direct protection against snake venom because it is actually a poor inhibitor of serine proteases. Further experiments showed that antibodies generated against MP-4 cross-react with the whole venom and provide protection to mice against Echis carinatus snake venom. This study shows that the MP-4 contributes significantly to the snake venom neutralization activity of M. pruriens seeds through an indirect antibody-mediated mechanism. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  4. Surprising Performance for Vibrational Frequencies of the Distinguishable Clusters with Singles and Doubles (DCSD) and MP2.5 Approximations

    OpenAIRE

    Kesharwani, Manoj K.; Sylvetsky, Nitai; Martin, Jan M. L.

    2017-01-01

    We show that the DCSD (distinguishable clusters with all singles and doubles) correlation method permits the calculation of vibrational spectra at near-CCSD(T) quality but at no more than CCSD cost, and with comparatively inexpensive analytical gradients. For systems dominated by a single reference configuration, even MP2.5 is a viable alternative, at MP3 cost. MP2.5 performance for vibrational frequencies is comparable to double hybrids such as DSD-PBEP86-D3BJ, but without resorting to empir...

  5. An individual-based approach to SIR epidemics in contact networks.

    Science.gov (United States)

    Youssef, Mina; Scoglio, Caterina

    2011-08-21

    Many approaches have recently been proposed to model the spread of epidemics on networks. For instance, the Susceptible/Infected/Recovered (SIR) compartmental model has successfully been applied to different types of diseases that spread out among humans and animals. When this model is applied on a contact network, the centrality characteristics of the network plays an important role in the spreading process. However, current approaches only consider an aggregate representation of the network structure, which can result in inaccurate analysis. In this paper, we propose a new individual-based SIR approach, which considers the whole description of the network structure. The individual-based approach is built on a continuous time Markov chain, and it is capable of evaluating the state probability for every individual in the network. Through mathematical analysis, we rigorously confirm the existence of an epidemic threshold below which an epidemic does not propagate in the network. We also show that the epidemic threshold is inversely proportional to the maximum eigenvalue of the network. Additionally, we study the role of the whole spectrum of the network, and determine the relationship between the maximum number of infected individuals and the set of eigenvalues and eigenvectors. To validate our approach, we analytically study the deviation with respect to the continuous time Markov chain model, and we show that the new approach is accurate for a large range of infection strength. Furthermore, we compare the new approach with the well-known heterogeneous mean field approach in the literature. Ultimately, we support our theoretical results through extensive numerical evaluations and Monte Carlo simulations. Published by Elsevier Ltd.

  6. ISA-TAB-Nano: A Specification for Sharing Nanomaterial Research Data in Spreadsheet-based Format

    Science.gov (United States)

    2013-01-01

    Background and motivation The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has yet to adopt similar standards to share the diverse and multi-dimensional types of data (including metadata) pertaining to the description and characterization of nanomaterials. Owing to the lack of standardization in representing and sharing nanomaterial data, most of the data currently shared via publications and data resources are incomplete, poorly-integrated, and not suitable for meaningful interpretation and re-use of the data. Specifically, in its current state, data cannot be effectively utilized for the development of predictive models that will inform the rational design of nanomaterials. Results We have developed a specification called ISA-TAB-Nano, which comprises four spreadsheet-based file formats for representing and integrating various types of nanomaterial data. Three file formats (Investigation, Study, and Assay files) have been adapted from the established ISA-TAB specification; while the Material file format was developed de novo to more readily describe the complexity of nanomaterials and associated small molecules. In this paper, we have discussed the main features of each file format and how to use them for sharing nanomaterial descriptions and assay metadata. Conclusion The ISA-TAB-Nano file formats provide a general and flexible framework to record and integrate nanomaterial descriptions, assay data (metadata and endpoint measurements) and protocol information. Like ISA-TAB, ISA-TAB-Nano supports the use of ontology terms to promote standardized descriptions and to facilitate search and integration of the data. The ISA-TAB-Nano specification has been submitted as an ASTM work item to obtain community feedback and to provide a nanotechnology data-sharing standard for public development and adoption. PMID

  7. Isonicotinamide Enhances Sir2 Protein-mediated Silencing and Longevity in Yeast by Raising Intracellular NAD+ Concentration*

    Science.gov (United States)

    McClure, Julie M.; Wierman, Margaret B.; Maqani, Nazif; Smith, Jeffrey S.

    2012-01-01

    Sirtuins are an evolutionarily conserved family of NAD+-dependent protein deacetylases that function in the regulation of gene transcription, cellular metabolism, and aging. Their activity requires the maintenance of an adequate intracellular NAD+ concentration through the combined action of NAD+ biosynthesis and salvage pathways. Nicotinamide (NAM) is a key NAD+ precursor that is also a byproduct and feedback inhibitor of the deacetylation reaction. In Saccharomyces cerevisiae, the nicotinamidase Pnc1 converts NAM to nicotinic acid (NA), which is then used as a substrate by the NAD+ salvage pathway enzyme NA phosphoribosyltransferase (Npt1). Isonicotinamide (INAM) is an isostere of NAM that stimulates yeast Sir2 deacetylase activity in vitro by alleviating the NAM inhibition. In this study, we determined that INAM stimulates Sir2 through an additional mechanism in vivo, which involves elevation of the intracellular NAD+ concentration. INAM enhanced normal silencing at the rDNA locus but only partially suppressed the silencing defects of an npt1Δ mutant. Yeast cells grown in media lacking NA had a short replicative life span, which was extended by INAM in a SIR2-dependent manner and correlated with increased NAD+. The INAM-induced increase in NAD+ was strongly dependent on Pnc1 and Npt1, suggesting that INAM increases flux through the NAD+ salvage pathway. Part of this effect was mediated by the NR salvage pathways, which generate NAM as a product and require Pnc1 to produce NAD+. We also provide evidence suggesting that INAM influences the expression of multiple NAD+ biosynthesis and salvage pathways to promote homeostasis during stationary phase. PMID:22539348

  8. Isonicotinamide enhances Sir2 protein-mediated silencing and longevity in yeast by raising intracellular NAD+ concentration.

    Science.gov (United States)

    McClure, Julie M; Wierman, Margaret B; Maqani, Nazif; Smith, Jeffrey S

    2012-06-15

    Sirtuins are an evolutionarily conserved family of NAD(+)-dependent protein deacetylases that function in the regulation of gene transcription, cellular metabolism, and aging. Their activity requires the maintenance of an adequate intracellular NAD(+) concentration through the combined action of NAD(+) biosynthesis and salvage pathways. Nicotinamide (NAM) is a key NAD(+) precursor that is also a byproduct and feedback inhibitor of the deacetylation reaction. In Saccharomyces cerevisiae, the nicotinamidase Pnc1 converts NAM to nicotinic acid (NA), which is then used as a substrate by the NAD(+) salvage pathway enzyme NA phosphoribosyltransferase (Npt1). Isonicotinamide (INAM) is an isostere of NAM that stimulates yeast Sir2 deacetylase activity in vitro by alleviating the NAM inhibition. In this study, we determined that INAM stimulates Sir2 through an additional mechanism in vivo, which involves elevation of the intracellular NAD(+) concentration. INAM enhanced normal silencing at the rDNA locus but only partially suppressed the silencing defects of an npt1Δ mutant. Yeast cells grown in media lacking NA had a short replicative life span, which was extended by INAM in a SIR2-dependent manner and correlated with increased NAD(+). The INAM-induced increase in NAD(+) was strongly dependent on Pnc1 and Npt1, suggesting that INAM increases flux through the NAD(+) salvage pathway. Part of this effect was mediated by the NR salvage pathways, which generate NAM as a product and require Pnc1 to produce NAD(+). We also provide evidence suggesting that INAM influences the expression of multiple NAD(+) biosynthesis and salvage pathways to promote homeostasis during stationary phase.

  9. The wheat transcription factor, TabHLH39, improves tolerance to multiple abiotic stressors in transgenic plants.

    Science.gov (United States)

    Zhai, Yiqian; Zhang, Lichao; Xia, Chuan; Fu, Silu; Zhao, Guangyao; Jia, Jizeng; Kong, Xiuying

    2016-05-13

    Although bHLH transcription factors play important roles regulating plant development and abiotic stress response and tolerance, few functional studies have been performed in wheat. In this study, we isolated and characterized a bHLH gene, TabHLH39, from wheat. The TabHLH39 gene is located on wheat chromosome 5DL, and the protein localized to the nucleus and activated transcription. TabHLH39 showed variable expression in roots, stems, leaves, glumes, pistils and stamens and was induced by polyethylene glycol, salt and cold treatments. Further analysis revealed that TabHLH39 overexpression in Arabidopsis significantly enhanced tolerance to drought, salt and freezing stress during the seedling stage, which was also demonstrated by enhanced abiotic stress-response gene expression and changes to several physiological indices. Therefore, TabHLH39 has potential in transgenic breeding applications to improve abiotic stress tolerance in crops. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Microstrip Cross-coupled Interdigital SIR Based Bandpass Filter

    Directory of Open Access Journals (Sweden)

    R. K. Maharjan

    2012-09-01

    Full Text Available A simple and compact 4.9 GHz bandpass filter for C-band applications is proposed. This paper presents a novel microstrip cross-coupled interdigital half-wavelength stepped impedance resonator (SIR based bandpass filter (BPF.The designed structure is similar to that of a combination of two parallel interdigital capacitors. The scattering parameters of the structure are measured using vector network analyzer (VNA. The self generated capacitive and inductive reactances within the interdigital resonators exhibited in a resonance frequency of 4.9 GHz. The resonant frequency and bandwidth of the capacitive cross-coupled resonator is directly optimized from the physical arrangement of the resonators. The measured insertion loss (S21 and return loss (S11 were 0.3 dB and 28 dB, respectively, at resonance frequency which were almost close to the simulation results.

  11. Wavelet transform of generalized functions in K ′{Mp} spaces

    Indian Academy of Sciences (India)

    Using convolution theory in K{Mp} space we obtain bounded results for the wavelet transform. Calderón-type reproducing formula is derived in distribution sense as an application of the same. An inversion formula for the wavelet transform of generalized functions is established. Keywords. Continuous wavelet transform ...

  12. Sir Charles Alfred Ballance (1856-1936) and the introduction of facial nerve crossover anastomosis in 1895

    NARCIS (Netherlands)

    Van de Graaf, Robert C.; Ijpma, Frank F. A.; Nicolai, Jean-Philippe A.

    Sir Charles Ballance (1856-1936) was the first surgeon in history to perform a facial nerve crossover anastomosis in 1895. Although, recently, several papers on the history of facial nerve surgery have been published, little is known about this historically important operation, the theoretical

  13. Digital radiograph of the middle phalanx of the third finger (MP3) region as a tool for skeletal maturity assessment.

    Science.gov (United States)

    Hegde, Deepa Y; Baliga, Sudhindra; Yeluri, Ramakrishna; Munshi, A K

    2012-01-01

    To evaluate the reliability of the digital radiograph of the middle phalanx of the third finger (MP3) in skeletal maturity assessment. Fifty children (24 girls and 26 boys) belonging to the circumpubertal age-group were selected for the study. Two radiographs - lateral cephalogram and digital radiograph of the MP3 region - were taken in each child. Age assessment was based on the changes in shape of the cervical vertebrae and the epiphysis of the middle phalanx of the third finger of the left hand. The radiographs were assessed by three examiners. The inter- and intraexaminer variability were determined by the Wilcoxon rank sign test and the Kruskal-Wallis test and were found to be nonsignificant. Examiner 3 showed the best intraexaminer agreement and was selected to evaluate the radiographs for the entire study. The correlation determined between the MP3 stages and cervical vertebrae maturity index (CVMI) stages, the peak-wise distribution of the MP3 stages, and the correlation between the MP3 stages and the chronological age were found to be highly significant. Digital radiograph of the MP3 region is definitely a simple, reliable, cost-effective, and time-saving technique for the assessment of skeletal maturity.

  14. CcMP-II, a new hemorrhagic metalloproteinase from Cerastes cerastes snake venom: purification, biochemical characterization and amino acid sequence analysis.

    Science.gov (United States)

    Boukhalfa-Abib, Hinda; Laraba-Djebari, Fatima

    2015-01-01

    Snake venom metalloproteinases (SVMPs) are the most abundant components in snake venoms. They are important in the induction of systemic alterations and local tissue damage after envenomation. CcMP-II, which is a metalloproteinase purified from Cerastes cerastes snake venom, was obtained by a combination of gel filtration, ion-exchange and affinity chromatographies. It was homogeneous on SDS-PAGE, with a molecular mass estimated to 35kDa and presents a pI of 5.6. CcMP-II has an N-terminal sequence of EDRHINLVSVADHRMXTKY, with high levels of homology with those of the members of class P-II of SVMPs, which comprises metalloproteinase and disintegrin-like domains together. This proteinase displayed a fibrinogenolytic and hemorrhagic activities. The proteolytic and hemorrhagic activities of CcMP-II were inhibited by EDTA and 1,10-phenanthroline. However, these activities were not affected by aprotinine and PMSF, suggesting that CcMP-II is a zinc-dependent hemorrhagic metalloproteinase with an α-fibrinogenase activity. The hemorrhagic metalloproteinase CcMP-II was also able to hydrolyze extracellular matrix components, such as type IV collagen and laminin. These results indicate that CcMP-II is implicated in the local and systemic bleeding, contributing thus in the toxicity of C. cerastes venom. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. Efeitos do mp3 player na audição

    Directory of Open Access Journals (Sweden)

    Daniela Dalapicula Barcelos

    2014-06-01

    Full Text Available Objetivo investigar se há dano e a extensão do mesmo com o uso de MP3 player. Métodos aplicação do exame de Emissões Otoacústicas por Produto de Distorção e Emissões Otoacústicas Transientes, em 30 indivíduos expostos ao MP3 Player, sendo 15 deles no grupo controle (intensidade média de 85 dBNA e 15 no grupo análise (intensidade média de 110 dBNA, ambos expostos por 15 minutos. O método utilizado para análise estatística foi inferencial (teste “t” para amostras pareadas. Resultados o grupo controle apresentou alteração na frequência de 1,5kHz nas Emissões Otoacústicas Transientes e na frequência de 6kHz no Produto de Distorção. Enquanto o grupo análise apresentou alteração nas frequências de 2, 3, 4kHz e na amplitude média de todas as frequências, nas Emissões Otoacústicas Transientes e nas frequências de 3 e 6kHz na Produto de Distorção. Conclusão o estudo mostrou que pessoas expostas a ruídos intensos, sendo o aparelho de MP3 Player fonte deste estudo, apresentam diminuição significante da amplitude, que indica alteração temporária das células da cóclea, podendo tornar-se uma lesão permanente caso a exposição seja contínua.

  16. PENGARUH BRAND EQUITY TERHADAP KEPUTUSAN PEMBELIAN KONSUMEN PADA PRODUK SAMSUNG GALAXY TAB DI MAKASSAR

    OpenAIRE

    SYAHPUTRA, ANDY

    2014-01-01

    2014 Penelitian ini bertujuan untuk mengetahui pengaruh ekuitas merek (Brand Equity) terhadap keputusan pembelian konsumen pada produk Samsung Galaxy Tab di Makassar. Data penelitian ini diperoleh dari kusioner (primer) dengan pihak pengguna Samsung Galaxy Tab. Temuan penelitian menunjukkan bahwa variabel brand equity yang terdiri dari dimensi kesadaran merek (brand awareness), kesan kualitas (perceive quality), asosiasi merek (brand ...

  17. Influence of surface layer removal of shade guide tabs on the measured color by spectrophotometer and spectroradiometer.

    Science.gov (United States)

    Kim, Jin-Cheol; Yu, Bin; Lee, Yong-Keun

    2008-12-01

    To determine the changes in color parameters of Vitapan 3D-Master shade guide tabs by a spectrophotometer (SP) or a spectroradiometer (SR), and by the removal of the surface layer of the tabs that was performed to make a flat measuring surface for the SP color measurement. Color of the shade tabs was measured before and after removing the surface layer of the tabs using SP and SR. Correlations between the color parameters between the original (OR) and the surface layer removed (RM) tabs and between the SP and the SR measurements were determined (alpha=0.05). Based on SP, the lightness, chroma, CIE a* and b* values measured after the surface layer removal were higher than those of the original tabs except a few cases. Based on SR, the chroma and CIE a* and b* values measured after surface layer removal were higher than those of the original tabs except a few cases; however, in case of the lightness, the changes varied by the shade designation. Type of instrument influenced the changes in color parameters based on paired t-test (pspectrophotometer or a spectroradiometer, measurement protocols should be specified because color difference by the surface layer removal and the instrument was high.

  18. The β-1,3-glucanosyltransferase Gas1 regulates Sir2-mediated rDNA stability in Saccharomyces cerevisiae.

    Science.gov (United States)

    Ha, Cheol Woong; Kim, Kwantae; Chang, Yeon Ji; Kim, Bongkeun; Huh, Won-Ki

    2014-07-01

    In Saccharomyces cerevisiae, the stability of highly repetitive rDNA array is maintained through transcriptional silencing. Recently, a β-1,3-glucanosyltransferase Gas1 has been shown to play a significant role in the regulation of transcriptional silencing in S. cerevisiae. Here, we show that the gas1Δ mutation increases rDNA silencing in a Sir2-dependent manner. Remarkably, the gas1Δ mutation induces nuclear localization of Msn2/4 and stimulates the expression of PNC1, a gene encoding a nicotinamidase that functions as a Sir2 activator. The lack of enzymatic activity of Gas1 or treatment with a cell wall-damaging agent, Congo red, exhibits effects similar to those of the gas1Δ mutation. Furthermore, the loss of Gas1 or Congo red treatment lowers the cAMP-dependent protein kinase (PKA) activity in a cell wall integrity MAP kinase Slt2-dependent manner. Collectively, our results suggest that the dysfunction of Gas1 plays a positive role in the maintenance of rDNA integrity by decreasing PKA activity and inducing the accumulation of Msn2/4 in the nucleus. It seems that nuclear-localized Msn2/4 stimulate the expression of Pnc1, thereby enhancing the association of Sir2 with rDNA and promoting rDNA stability. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  19. Sir Robert Ball: Victorian Astronomer and Lecturer par excellence

    Science.gov (United States)

    Jones, R. I. G.

    2005-12-01

    Between 1875 and 1910 Sir Robert Stawell Ball gave an estimated 2,500 lectures in towns and cities all over the British Isles and abroad. This paper traces his lecturing career from its beginnings in Ireland to the triumphs of the Royal Institution, and on lecture tours in the United States of America. After a period in mathematics and mechanics, he became a populariser of science, especially astronomy, and found fame and fortune among the working classes and the aristocracy. What motivated him to tireless travels is uncertain, but it might have been that it was rewarding, financially and to his reputation. Whatever his motives, contemporary accounts are clear that BallÕs lectures were extremely popular and well-received.

  20. PENGEMBANGAN PROTOTIPE SISTEM KONTROL MP3 PLAYER BERBASIS RADIO FREQUENCY IDENTIFICATION PADA SISTEM PELAYANAN INFORMASI OBJEK MUSEUM

    Directory of Open Access Journals (Sweden)

    I Gede Nurhayata

    2015-05-01

    Full Text Available Adanya perbedaan dalam penyampaian informasi objek museum secara lisan oleh beberapa pemandu wisata menunjukkan kurangnya standarisasi layanan informasi objek museum. Penelitian ini bertujuan menghasilkan prototipe perangkat elektronik mobile sebagai salah satu alternatif standarisasi sistem pelayanan informasi objek museum. Penelitian ini menerapkan metode pengembangan dengan dua sub sistem perangkat pelayanan informasi objek meliputi:1 sistem identifikasi objek museum berbasis Radio Frequency Identification (RFID dan 2 sistem penyampaian informasi audio berbasis MP3 Player. Sub sistem pertama bertujuan mengenali identitas objek museum melalui perangkat RFID reader.  Sedangkan sub sistem kedua, bertujuan mengakses dan memainkan file audio pada MP3 player sehingga didengar melalui headphone. Hasil penelitian pada tahun pertama ini berupa perangkat keras dan perangkat lunak dalam identifikasi Tag ID dan kode tombol remote kontrol MP3 player. Berdasarkan data kinerja perangkat lunak dapat disimpulkan bahwa mikrokontroler AT89S51 dalam identifikasi Tag ID dan kode tombol pada remote kontrol MP3 player telah bekerja sesuai rancangan yang diharapkan. Disamping itu telah berhasil mengakses nomor informasi file audio sesuai dengan nomor identitas objek.

  1. Crystallization and preliminary X-ray characterization of the genetically encoded fluorescent calcium indicator protein GCaMP2

    International Nuclear Information System (INIS)

    Rodríguez Guilbe, María M.; Alfaro Malavé, Elisa C.; Akerboom, Jasper; Marvin, Jonathan S.; Looger, Loren L.; Schreiter, Eric R.

    2008-01-01

    The genetically encoded fluorescent calcium-indicator protein GCaMP2 was crystallized in the calcium-saturated form. X-ray diffraction data were collected to 2.0 Å resolution and the structure was solved by molecular replacement. Fluorescent proteins and their engineered variants have played an important role in the study of biology. The genetically encoded calcium-indicator protein GCaMP2 comprises a circularly permuted fluorescent protein coupled to the calcium-binding protein calmodulin and a calmodulin target peptide, M13, derived from the intracellular calmodulin target myosin light-chain kinase and has been used to image calcium transients in vivo. To aid rational efforts to engineer improved variants of GCaMP2, this protein was crystallized in the calcium-saturated form. X-ray diffraction data were collected to 2.0 Å resolution. The crystals belong to space group C2, with unit-cell parameters a = 126.1, b = 47.1, c = 68.8 Å, β = 100.5° and one GCaMP2 molecule in the asymmetric unit. The structure was phased by molecular replacement and refinement is currently under way

  2. A new system for assessment of growth using mandibular canine calcification stages and its correlation with modified MP3 stages

    Directory of Open Access Journals (Sweden)

    Gautham Hegde

    2014-01-01

    Full Text Available Objective: Orthodontic diagnosis and treatment planning for growing children must involve growth prediction, especially in the treatment of skeletal problems. Studies have shown that a strong association exists between skeletal maturity and dental calcification stages. The present study was therefore taken up to provide a simple and practical method for assessing skeletal maturity using a dental periapical film and standard dental X-ray machine, to compare the developmental stages of the mandibular canine with that of developmental stages of modified MP3 and to find out if any correlation exists, to determine if the developmental stages of the mandibular canine alone can be used as a reliable indicator for assessment of skeletal maturity. Materials and Methods: A total of 160 periapical radiographs, of the mandibular right canine and the MP3 region was taken and assessed according to the Dermirjian′s stages of dental calcification and the modified MP3 stages. Results and Discussion: The correlation coefficient between MP3 stages and developmental stages of mandibular canine was found to be significant in both male and female groups. When the canine calcification stages were compared with the MP3 stages it was found that with the exception of the D stage of canine calcification the remaining stages showed a very high correlation with the modified MP3 stages. Conclusion: The correlation between the mandibular canine calcification stages, and the MP3 stages was found to be significant. The canine calcification could be used as a sole indicator for assessment of skeletal maturity.

  3. Comparing the OpenMP, MPI, and Hybrid Programming Paradigm on an SMP Cluster

    Science.gov (United States)

    Jost, Gabriele; Jin, Hao-Qiang; anMey, Dieter; Hatay, Ferhat F.

    2003-01-01

    Clusters of SMP (Symmetric Multi-Processors) nodes provide support for a wide range of parallel programming paradigms. The shared address space within each node is suitable for OpenMP parallelization. Message passing can be employed within and across the nodes of a cluster. Multiple levels of parallelism can be achieved by combining message passing and OpenMP parallelization. Which programming paradigm is the best will depend on the nature of the given problem, the hardware components of the cluster, the network, and the available software. In this study we compare the performance of different implementations of the same CFD benchmark application, using the same numerical algorithm but employing different programming paradigms.

  4. An efficient parallel algorithm for the calculation of unrestricted canonical MP2 energies.

    Science.gov (United States)

    Baker, Jon; Wolinski, Krzysztof

    2011-11-30

    We present details of our efficient implementation of full accuracy unrestricted open-shell second-order canonical Møller-Plesset (MP2) energies, both serial and parallel. The algorithm is based on our previous restricted closed-shell MP2 code using the Saebo-Almlöf direct integral transformation. Depending on system details, UMP2 energies take from less than 1.5 to about 3.0 times as long as a closed-shell RMP2 energy on a similar system using the same algorithm. Several examples are given including timings for some large stable radicals with 90+ atoms and over 3600 basis functions. Copyright © 2011 Wiley Periodicals, Inc.

  5. Numerical simulation of the effects of hanging sound absorbers on TABS cooling performance

    DEFF Research Database (Denmark)

    Rage, Nils; Kazanci, Ongun Berk; Olesen, Bjarne W.

    2016-01-01

    simulating a two-person office of 20 m2, with a typical cooling load of 42 W/m2. The results show that covering 60% of the ceiling surface with sound absorbers hanging at 300 mm from the ceiling active deck is expected to reduce the cooling capacity coefficient of TABS by 15.8%. This drops to 25......Recently there has been a considerable increase in the use of Thermally-Active Building Systems (TABS) in Europe as an energy-efficient and economical cooling and heating solution for buildings. However, this widespread solution requires large uncovered hard surfaces indoors, which can lead...... to a degradation of the room acoustic comfort. Therefore, challenges arise when this system has to be combined with acoustic requirements. Soffit-hanging sound absorbers embody a promising solution. This study focuses on quantifying their impact on the cooling performance of TABS, assessed by means of the cooling...

  6. Savings through the use of adaptive predictive control of thermo-active building systems (TABS): A case study

    International Nuclear Information System (INIS)

    Schmelas, Martin; Feldmann, Thomas; Bollin, Elmar

    2017-01-01

    Highlights: •An adaptive and predictive algorithm for the control of TABS (AMLR) is evaluated. •Comparison of standard TABS control and AMLR over a period of nine month each. •Thermal comfort, energy and investment savings in a passive seminar building. •Reduction of peak power of chilled beams (auxiliary system) with AMLR algorithm. •Simplification of the TABS hydraulics with AMLR algorithm. -- Abstract: The building sector is one of the main consumers of energy. Therefore, heating and cooling concepts for renewable energy sources become increasingly important. For this purpose, low-temperature systems such as thermo-active building systems (TABS) are particularly suitable. This paper presents results of the use of a novel adaptive and predictive computation method, based on multiple linear regression (AMLR) for the control of TABS in a passive seminar building. Detailed comparisons are shown between the standard TABS and AMLR strategies over a period of nine months each. In addition to the reduction of thermal energy use by approx. 26% and a significant reduction of the TABS pump operation time, this paper focuses on investment savings in a passive seminar building through the use of the AMLR strategy. This includes the reduction of peak power of the chilled beams (auxiliary system) as well as a simplification of the TABS hydronic circuit and the saving of an external temperature sensor. The AMLR proves its practicality by learning from the historical building operation, by dealing with forecasting errors and it is easy to integrate into a building automation system.

  7. New approaches to improve a WCDMA SIR estimator by employing different post-processing stages

    Directory of Open Access Journals (Sweden)

    Amnart Chaichoet

    2008-09-01

    Full Text Available For effective control of transmission power in WCDMA mobile systems, a good estimate of signal-to-interference ratio (SIR is needed. Conventionally, an adaptive SIR estimator employs a moving average (MA filter (Yoon et al., 2002 to encounter fading channel distortion. However, the resulting estimate seems to have high estimation error due to fluctuation in the channel variation. In this paper, an additional post-processing stage is proposed to improve the estimation accuracy by reducing the variation of the estimate. Four variations of post-processing stages, namely 1 a moving average (MA postfilter,2 an exponential moving average (EMA post-filter, 3 an IIR post-filter and 4 least-mean-squared (LMS adaptive post-filter, are proposed and their optimal performance in terms of root-mean-square error (RMSE are then compared by simulation. The results show the best comparable performance when the MA and LMS post-filter are used. However, the MA post-filter requires a lookup table of filter order for optimal performance at different channel conditions, while the LMS post-filter can be used conveniently without a lookup table.

  8. MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3

    Directory of Open Access Journals (Sweden)

    Donaldson Paul J

    2001-08-01

    Full Text Available Abstract Background Although MP20 is the second most highly expressed membrane protein in the lens its function remains an enigma. Putative functions for MP20 have recently been inferred from its assignment to the tetraspanin superfamily of integral membrane proteins. Members of this family have been shown to be involved in cellular proliferation, differentiation, migration, and adhesion. In this study, we show that MP20 associates with galectin-3, a known adhesion modulator. Results MP20 and galectin-3 co-localized in selected areas of the lens fiber cell plasma membrane. Individually, these proteins purified with apparent molecular masses of 60 kDa and 22 kDa, respectively. A 104 kDa complex was formed in vitro upon mixing the purified proteins. A 102 kDa complex of MP20 and galectin-3 could also be isolated from detergent-solubilized native fiber cell membranes. Binding between MP20 and galectin-3 was disrupted by lactose suggesting the lectin site was involved in the interaction. Conclusions MP20 adds to a growing list of ligands of galectin-3 and appears to be the first representative of the tetraspanin superfamily identified to possess this specificity.

  9. Design of power controller in CDMA system with power and SIR error minimization

    Institute of Scientific and Technical Information of China (English)

    Shulan KONG; Huanshui ZHANG; Zhaosheng ZHANG; Hongxia WANG

    2007-01-01

    In this paper, an uplink power control problem is considered for code division multiple access (CDMA) systems. A distributed algorithm is proposed based on linear quadratic optimal control theory. The proposed scheme minimizes the sum of the power and the error of signal-to-interference ratio (SIR). A power controller is designed by constructing an optimization problem of a stochastic linear quadratic type in Krein space and solving a Kalman filter problem.

  10. Cross Layer Analysis of P2MP Hybrid FSO/RF Network

    KAUST Repository

    Rakia, Tamer; Gebali, Fayez; Yang, Hong-Chuan; Alouini, Mohamed-Slim

    2017-01-01

    This paper presents and analyzes a point-tomultipoint (P2MP) network that uses a number of freespace optical (FSO) links for data transmission from the central node to the different remote nodes of the network. A common backup radio frequency (RF

  11. Galaxy Tab Covers Samsung TouchWiz Interface

    CERN Document Server

    Gralla, Preston

    2011-01-01

    Galaxy Tab lets you work, play, read, and connect on the go, but mastering its TouchWiz interface and finding the best apps can be tricky-unless you have this Missing Manual. Gadget whiz Preston Gralla provides crystal-clear explanations and step-by-step instructions to get you up to speed quickly, whether you have the 3G/4G or Wi-Fi version of this amazing device. The important stuff you need to know: Design your experience. Add interactive widgets and mini-apps to your screen with TouchWiz.Satisfy your appetite. Download thousands of games and apps from the Android Market.Keep in touch. Ch

  12. Quartic scaling MP2 for solids: A highly parallelized algorithm in the plane wave basis

    Science.gov (United States)

    Schäfer, Tobias; Ramberger, Benjamin; Kresse, Georg

    2017-03-01

    We present a low-complexity algorithm to calculate the correlation energy of periodic systems in second-order Møller-Plesset (MP2) perturbation theory. In contrast to previous approximation-free MP2 codes, our implementation possesses a quartic scaling, O ( N 4 ) , with respect to the system size N and offers an almost ideal parallelization efficiency. The general issue that the correlation energy converges slowly with the number of basis functions is eased by an internal basis set extrapolation. The key concept to reduce the scaling is to eliminate all summations over virtual orbitals which can be elegantly achieved in the Laplace transformed MP2 formulation using plane wave basis sets and fast Fourier transforms. Analogously, this approach could allow us to calculate second order screened exchange as well as particle-hole ladder diagrams with a similar low complexity. Hence, the presented method can be considered as a step towards systematically improved correlation energies.

  13. Individualized FAC on bottom tab subassemblies to minimize adhesive gap between emitter and optics

    Science.gov (United States)

    Sauer, Sebastian; Müller, Tobias; Haag, Sebastian; Beleke, Andreas; Zontar, Daniel; Baum, Christoph; Brecher, Christian

    2017-02-01

    High Power Diode Laser (HPDL) systems with short focal length fast-axis collimators (FAC) require submicron assembly precision. Conventional FAC-Lens assembly processes require adhesive gaps of 50 microns or more in order to compensate for component tolerances (e.g. deviation of back focal length) and previous assembly steps. In order to control volumetric shrinkage of fast-curing UV-adhesives shrinkage compensation is mandatory. The novel approach described in this paper aims to minimize the impact of volumetric shrinkage due to the adhesive gap between HPDL edge emitters and FAC-Lens. Firstly, the FAC is actively aligned to the edge emitter without adhesives or bottom tab. The relative position and orientation of FAC to emitter are measured and stored. Consecutively, an individual subassembly of FAC and bottom tab is assembled on Fraunhofer IPT's mounting station with a precision of +/-1 micron. Translational and lateral offsets can be compensated, so that a narrow and uniform glue gap for the consecutive bonding process of bottom tab to heatsink applies (Figure 4). Accordingly, FAC and bottom tab are mounted to the heatsink without major shrinkage compensation. Fraunhofer IPT's department assembly of optical systems and automation has made several publications regarding active alignment of FAC lenses [SPIE LASE 8241-12], volumetric shrinkage compensation [SPIE LASE 9730-28] and FAC on bottom tab assembly [SPIE LASE 9727-31] in automated production environments. The approach described in this paper combines these and is the logical continuation of that work towards higher quality of HPDLs.

  14. Praktik pemberian makanan pendamping ASI (MP-ASI bukan faktor risiko kejadian stunting pada anak usia 6-23 bulan

    Directory of Open Access Journals (Sweden)

    Hildagardis M.E Nai

    2016-08-01

    status, complementary foods ABSTRAKLatar belakang: Stunting merefleksikan kegagalan proses mencapai potensi pertumbuhan linear sebagai akibat dari kondisi kesehatan dan gizi yang tidak optimal. Salah satu penyebab kejadian stunting adalah kuantitas dan kualitas MP-ASI yang rendah.Tujuan: Untuk mengidentifikasi risiko praktik pemberian MP-ASI seperti usia pengenalan MP-ASI, keragaman MP-ASI, dan frekuensi MP-ASI dengan kejadian stunting pada anak usia 6-23 bulan di Kecamatan Sedayu, Bantul, Yogyakarta.Metode: Rancangan penelitian ini adalah kasus-kontrol dengan perbandingan 1:1 dan menggunakan pendekatan kuantitatif-kualitatif model concurrent embedded. Kasus adalah anak usia 6-23 bulan yang memiliki skor-z PB/U <-2SD. Kontrol adalah anak usia 6-23 bulan yang memiliki skor-z PB/U ≥-2SD yang tinggal berdekatan dengan kelompok kasus. Analisis data menggunakan analisis univariat (deskriptif, bivariat (uji chi-square dan multivariat (uji regresi logistik berganda.Hasil: Analisis bivariat menunjukkan usia pengenalan MP-ASI (OR=1,07, keragaman MP-ASI (OR=1,17, dan frekuensi pemberian MP-ASI (OR=1,69 bukan faktor risiko kejadian stunting (p>0,05. Skor keragaman MP-ASI yang lebih rendah (kelompok makanan ≤2, 3, 4 berhubungan dengan peningkatan risiko kejadian stunting berturut-turut OR=2,24, 95% CI:1,00-5,01; OR=1,82, 95% CI:0,96-3,45; OR=1,66, 95% CI:0,81-3,46. Analisis multivariat menunjukkan faktor risiko kejadian stunting adalah tinggi badan ibu (OR=1,86 dan riwayat berat badan lahir rendah (BBLR (OR=3,23,.Kesimpulan: Praktik pemberian MP-ASI seperti usia pengenalan, keragaman, dan frekuensi pemberian MP-ASI bukan merupakan faktor risiko kejadian stunting pada anak usia 6-23 bulan. Faktor risiko kejadian stunting pada anak usia 6-23 bulan yang bermakna adalah tinggi badan ibu dan riwayat BBLR.KATA KUNCI: stunting, asupan makan, status gizi, MP-ASI

  15. Atomic structure calculations on the CRAY X-MP

    International Nuclear Information System (INIS)

    Fischer, C.F.

    1989-01-01

    Atomic structure calculations require both radial and angular integrations, where the latter are often based on Racah algebra. With relatively minor modifications, good performance is obtained on vector machines for radial integrations. Angular integrations, however, present the bottleneck. In this paper some recent improvements in the algorithms for angular integrations are described, as well as some multitasking experiments on the CRAY X-MP and CRAY 2. These show that the workload can easily be distributed evenly among available processors with dynamic scheduling

  16. OpenMP performance for benchmark 2D shallow water equations using LBM

    Science.gov (United States)

    Sabri, Khairul; Rabbani, Hasbi; Gunawan, Putu Harry

    2018-03-01

    Shallow water equations or commonly referred as Saint-Venant equations are used to model fluid phenomena. These equations can be solved numerically using several methods, like Lattice Boltzmann method (LBM), SIMPLE-like Method, Finite Difference Method, Godunov-type Method, and Finite Volume Method. In this paper, the shallow water equation will be approximated using LBM or known as LABSWE and will be simulated in performance of parallel programming using OpenMP. To evaluate the performance between 2 and 4 threads parallel algorithm, ten various number of grids Lx and Ly are elaborated. The results show that using OpenMP platform, the computational time for solving LABSWE can be decreased. For instance using grid sizes 1000 × 500, the speedup of 2 and 4 threads is observed 93.54 s and 333.243 s respectively.

  17. An efficient parallel algorithm for the calculation of canonical MP2 energies.

    Science.gov (United States)

    Baker, Jon; Pulay, Peter

    2002-09-01

    We present the parallel version of a previous serial algorithm for the efficient calculation of canonical MP2 energies (Pulay, P.; Saebo, S.; Wolinski, K. Chem Phys Lett 2001, 344, 543). It is based on the Saebo-Almlöf direct-integral transformation, coupled with an efficient prescreening of the AO integrals. The parallel algorithm avoids synchronization delays by spawning a second set of slaves during the bin-sort prior to the second half-transformation. Results are presented for systems with up to 2000 basis functions. MP2 energies for molecules with 400-500 basis functions can be routinely calculated to microhartree accuracy on a small number of processors (6-8) in a matter of minutes with modern PC-based parallel computers. Copyright 2002 Wiley Periodicals, Inc. J Comput Chem 23: 1150-1156, 2002

  18. Fungal lectin MpL enables entry of protein drugs into cancer cells and their subcellular targeting

    OpenAIRE

    ?urga, Simon; Nanut, Milica Peri?i?; Kos, Janko; Saboti?, Jerica

    2017-01-01

    Lectins have been recognized as promising carrier molecules for targeted drug delivery. They specifically bind carbohydrate moieties on cell membranes and trigger cell internalization. Fungal lectin MpL (Macrolepiota procera lectin) does not provoke cancer cell cytotoxicity but is able to bind aminopeptidase N (CD13) and integrin ?3?1, two glycoproteins that are overexpressed on the membrane of tumor cells. Upon binding, MpL is endocytosed in a clathrin-dependent manner and accumulates initia...

  19. Crystallization and preliminary X-ray diffraction studies of the putative haloalkane dehalogenase DppA from Plesiocystis pacifica SIR-I

    International Nuclear Information System (INIS)

    Bogdanović, Xenia; Hesseler, Martin; Palm, Gottfried J.; Bornscheuer, Uwe T.; Hinrichs, Winfried

    2010-01-01

    The crystallization and preliminary X-ray diffraction studies of DppA from P. pacifica SIR-I are reported. DppA from Plesiocystis pacifica SIR-I is a putative haloalkane dehalogenase (EC 3.8.1.5) and probably catalyzes the conversion of halogenated alkanes to the corresponding alcohols. The enzyme was expressed in Escherichia coli BL21 and purified to homogeneity by ammonium sulfate precipitation and reversed-phase and ion-exchange chromatography. The DppA protein was crystallized by the vapour-diffusion method and protein crystals suitable for data collection were obtained in the orthorhombic space group P2 1 2 1 2. The DppA crystal diffracted X-rays to 1.9 Å resolution using an in-house X-ray generator

  20. One day, Sir, you may tax it

    CERN Multimedia

    2011-01-01

    “One day, Sir, you may tax it”… Those are the words I used to get the audience's attention during my talk at the World Economic Forum’s annual meeting in Davos, where I was invited to speak about the science agenda in 2011. For those of you who don’t know the quote, it was Michael Faraday’s response to William Gladstone when asked to comment on the utility of his blue-sky research into the newfangled phenomenon of electricity.   So what does a 19th century English scientist have to do with the science agenda today? A great deal, I would contend. Faraday was doing basic science, but he had the foresight to realise that through applied research his findings could one day be developed into something taxable – as it turned out, electric light. Faraday had a sense of the potential of his blue-sky research, but he also appreciated that basic science alone is not enough. This was my key message in Davos. Governments often speak of ...

  1. Surprising performance for vibrational frequencies of the distinguishable clusters with singles and doubles (DCSD) and MP2.5 approximations

    Science.gov (United States)

    Kesharwani, Manoj K.; Sylvetsky, Nitai; Martin, Jan M. L.

    2017-11-01

    We show that the DCSD (distinguishable clusters with all singles and doubles) correlation method permits the calculation of vibrational spectra at near-CCSD(T) quality but at no more than CCSD cost, and with comparatively inexpensive analytical gradients. For systems dominated by a single reference configuration, even MP2.5 is a viable alternative, at MP3 cost. MP2.5 performance for vibrational frequencies is comparable to double hybrids such as DSD-PBEP86-D3BJ, but without resorting to empirical parameters. DCSD is also quite suitable for computing zero-point vibrational energies in computational thermochemistry.

  2. Effects of maleimide-polyethylene glycol-modified human hemoglobin (MP4 on tissue necrosis in SKH1-hr hairless mice

    Directory of Open Access Journals (Sweden)

    Goertz O

    2009-03-01

    Full Text Available Abstract Objective Tissue hypoxia after blood loss, replantation and flap reperfusion remains a challenging task in surgery. Normovolemic hemodilution improves hemorheologic properties without increasing oxygen carrying capacity. Red blood cell transfusion is the current standard of treatment with its attendant risks. The aim of this study was to investigate the potential of the chemically modified hemoglobin, MP4, to reduce skin flap necrosis and its effect on selected blood markers and kidneys. Materials and methods Tissue ischemia was induced in the ear of hairless mice (n = 26. Hemodilution was performed by replacing one third of blood volume with the similar amount of MP4, dextran, or blood. The extent of non-perfused tissue was assessed by intravital fluorescent microscopy. Results Of all groups, MP4 showed the smallest area of no perfusion (in percentage of the ear ± SEM: 16.3% ± 2.4, the control group the largest (22.4% ± 3.5. Leukocytes showed a significant increase in the MP4 and dextran group (from 8.7 to 13.6 respectively 15.4*109/l. On histology no changes of the kidneys could be observed. Conclusion MP4 causes an increase of leukocytes, improves the oxygen supply of the tissue and shows no evidence of renal impairment.

  3. Implementation of IMDCT Block of an MP3 Decoder through Optimization on the DCT Matrix

    Directory of Open Access Journals (Sweden)

    M. Galabov

    2004-12-01

    Full Text Available The paper describes an attempt to create an efficient dedicatedMP3-decoder, according to the MPEG-1 Layer III standard. A new methodof Inverse Modified Discrete Cosine Transform by optimization on theDiscrete Cosine Transform (DCT matrix is proposed and an assemblerprogram for Digital Signal Processor is developed. In addition, aprogram to calculate DCT using Lee's algorithm for any matrix of thesize 2M is created. The experimental results have proven that thedecoder is able to stream and decode MP3 in real time.

  4. The MP65 gene is required for cell wall integrity, adherence to epithelial cells and biofilm formation in Candida albicans

    Directory of Open Access Journals (Sweden)

    Girolamo Antonietta

    2011-05-01

    Full Text Available Abstract Background The MP65 gene of Candida albicans (orf19.1779 encodes a putative β-glucanase mannoprotein of 65 kDa, which plays a main role in a host-fungus relationship, morphogenesis and pathogenicity. In this study, we performed an extensive analysis of a mp65Δ mutant to assess the role of this protein in cell wall integrity, adherence to epithelial cells and biofilm formation. Results The mp65Δ mutant showed a high sensitivity to a range of cell wall-perturbing and degrading agents, especially Congo red, which induced morphological changes such as swelling, clumping and formation of hyphae. The mp65Δ mutant showed an activation of two MAPKs (Mkc1p and Cek1p, a high level of expression of two stress-related genes (DDR48 and SOD5, and a modulated expression of β-glucan epitopes, but no gross changes in cell wall polysaccharide composition. Interestingly, the mp65Δ mutant displayed a marked reduction in adhesion to BEC and Caco-2 cells and severe defects in biofilm formation when compared to the wild type. All of the mentioned properties were totally or partially recovered in a revertant strain, demonstrating the specificity of gene deletion. Conclusions We demonstrate that the MP65 gene of Candida albicans plays a significant role in maintaining cell wall integrity, as well as in adherence to epithelia and biofilm formation, which are major virulence attributes of this fungus.

  5. A study of the effectiveness of MP3 players to support family carers of people living with dementia at home.

    Science.gov (United States)

    Lewis, Virginia; Bauer, Michael; Winbolt, Margaret; Chenco, Carol; Hanley, Francine

    2015-03-01

    Music can be therapeutic to people with dementia; however, little is known about its effect on the family carers. This project aimed to (1) assess the effects of MP3 player use by a person with dementia on caregivers' mental health and wellbeing, including their self-care and health-promoting behavior and (2) determine whether MP3 player use increases caregivers' self-reported capacity to cope with their role. A pre-post quantitative and qualitative design was used. Carers completed a survey prior to commencing and four weeks after using the player. The survey included validated measures to assess the level of stress and coping among carers. Carers also kept a diary of the way they used the MP3 player. Half of the carers were interviewed about their experiences at the end of the study. Of 59 people who started using the MP3 player, 51 carers completed the four-week study period and surveys. Use of the MP3 player significantly decreased psychological distress, significantly improved the mental health and wellbeing of carers, significantly increased caregiver self-efficacy to manage symptoms of dementia, and was reported to provide valued respite from the high level of vigilance required for caring for a person with dementia. An MP3 player loaded with music can be a low cost and relatively simple and effective additional strategy to support families caring for people with dementia in the community.

  6. The community Noah land surface model with multiparameterization options (Noah-MP): 1. Model description and evaluation with local-scale measurements

    KAUST Repository

    Niu, Guo-Yue; Yang, Zong-Liang; Mitchell, Kenneth E.; Chen, Fei; Ek, Michael B.; Barlage, Michael; Kumar, Anil; Manning, Kevin; Niyogi, Dev; Rosero, Enrique; Tewari, Mukul; Xia, Youlong

    2011-01-01

    processes, and introduces a framework for multiple options to parameterize selected processes (Noah-MP). The Noah-MP's performance is evaluated at various local sites using high temporal frequency data sets, and results show the advantages of using multiple

  7. Thermal vacuum test of space equipment: tests of SIR-2 instrument Chandrayaan-1 mission

    Science.gov (United States)

    Sitek, P.

    2008-11-01

    We describe the reasons of proceeding Thermal-Vacuum tests for space electronic. We will answer on following questions: why teams are doing TV tests, what kind of phases should be simulated, which situations are the most critical during TV tests, what kind of results should be expected, which errors can be detect. As an example, will be shown TV-test of SIR-2 instrument for Chandrayaan-1 moon mission.

  8. The Biocarbon vascular access device (DiaTAB) for haemodialysis.

    Science.gov (United States)

    Smits, P J; Slooff, M J; Lichtendahl, D H; van der Hem, G K

    1985-01-01

    The Biocarbon vascular access device (DiaTAB) is a relatively new method in secondary access surgery. Punctures, often the cause of complications can be avoided because it is a no-needle method of dialysis. However thrombosis due to stenosis of the venous anastomosis or of the efferent vein is a continuing problem. A new experience is the fibrin flap formation under the plug of the device, which can be removed easily.

  9. Adolescents and MP3 players : Too many risks, too few precautions

    NARCIS (Netherlands)

    Vogel, I.; Verschuure, H.; Ploeg, C.P.B. van der; Brug, J.; Raat, H.

    2009-01-01

    OBJECTIVE. The goal was to assess risky and protective listening behaviors of adolescent users of MP3 players and the association of these behaviors with demographic characteristics and frequency of use. METHODS. In 2007, 1687 adolescents (12-19 years of age) in 68 classes in 15 Dutch secondary

  10. Adolescents and MP3 Players: Too Many Risks, Too Few Precautions

    NARCIS (Netherlands)

    I. Vogel (Ineke); H. Verschuure (Hans); C.P.B. van der Ploeg (Catharina); J. Brug (Hans); H. Raat (Hein)

    2009-01-01

    textabstractOBJECTIVE. The goal was to assess risky and protective listening behaviors of adolescent users of MP3 players and the association of these behaviors with demographic characteristics and frequency of use. METHODS. In 2007, 1687 adolescents (12–19 years of age) in 68 classes in 15

  11. Moniliophthora perniciosa necrosis- and ethylene-inducing protein 2 (MpNep2) as a metastable dimer in solution: structural and functional implications.

    Science.gov (United States)

    de Oliveira, Guilherme A P; Pereira, Elen G; Dias, Cristiano V; Souza, Theo L F; Ferretti, Giulia D S; Cordeiro, Yraima; Camillo, Luciana R; Cascardo, Júlio; Almeida, Fabio C; Valente, Ana Paula; Silva, Jerson L

    2012-01-01

    Understanding how Nep-like proteins (NLPs) behave during the cell cycle and disease progression of plant pathogenic oomycetes, fungi and bacteria is crucial in light of compelling evidence that these proteins play a role in Witches` Broom Disease (WBD) of Theobroma cacao, one of the most important phytopathological problems to afflict the Southern Hemisphere. The crystal structure of MpNep2, a member of the NLP family and the causal agent of WBD, revealed the key elements for its activity. This protein has the ability to refold after heating and was believed to act as a monomer in solution, in contrast to the related homologs MpNep1 and NPP from the oomyceteous fungus Phytophthora parasitica. Here, we identify and characterize a metastable MpNep2 dimer upon over-expression in Escherichia coli using different biochemical and structural approaches. We found using ultra-fast liquid chromatography that the MpNep2 dimer can be dissociated by heating but not by dilution, oxidation or high ionic strength. Small-angle X-ray scattering revealed a possible tail-to-tail interaction between monomers, and nuclear magnetic resonance measurements identified perturbed residues involved in the putative interface of interaction. We also explored the ability of the MpNep2 monomer to refold after heating or chemical denaturation. We observed that MpNep2 has a low stability and cooperative fold that could be an explanation for its structure and activity recovery after stress. These results can provide new insights into the mechanism for MpNep2's action in dicot plants during the progression of WBD and may open new avenues for the involvement of NLP- oligomeric species in phytopathological disorders.

  12. TAB2 Is Essential for Prevention of Apoptosis in Fetal Liver but Not for Interleukin-1 Signaling

    Science.gov (United States)

    Sanjo, Hideki; Takeda, Kiyoshi; Tsujimura, Tohru; Ninomiya-Tsuji, Jun; Matsumoto, Kunihiro; Akira, Shizuo

    2003-01-01

    The proinflammatory cytokine interleukin-1 (IL-1) transmits a signal via several critical cytoplasmic proteins such as MyD88, IRAKs and TRAF6. Recently, serine/threonine kinase TAK1 and TAK1 binding protein 1 and 2 (TAB1/2) have been identified as molecules involved in IL-1-induced TRAF6-mediated activation of AP-1 and NF-κB via mitogen-activated protein (MAP) kinases and IκB kinases, respectively. However, their physiological functions remain to be clarified. To elucidate their roles in vivo, we generated TAB2-deficient mice. The TAB2 deficiency was embryonic lethal due to liver degeneration and apoptosis. This phenotype was similar to that of NF-κB p65-, IKKβ-, and NEMO/IKKγ-deficient mice. However, the IL-1-induced activation of NF-κB and MAP kinases was not impaired in TAB2-deficient embryonic fibroblasts. These findings demonstrate that TAB2 is essential for embryonic development through prevention of liver apoptosis but not for the IL-1 receptor-mediated signaling pathway. PMID:12556483

  13. Heart Rate Monitor for Portable MP3 Player.

    Science.gov (United States)

    Kim, Jaywoo; Lee, Mi-Hee; Lee, Hyoung-Ki; Choi, Kiwan; Bang, Seokwon; Kim, Sangryong

    2005-01-01

    This paper presents a photoplethysmography sensor based on a heart rate monitor for a portable MP3 player. Two major design issues are addressed: one is to acquire the sensor signal with a proper amplitude despite a wide range of variation and the other is to handle the noise contaminated signal which is caused by a motion artifact. A benchmarking test with a professional medical photoplethysmography sensor shows that our device performs very well in calculating heart rate even though our photoplethysmography sensor module was designed to be cost effective.

  14. Dynamical Analysis of SIR Epidemic Models with Distributed Delay

    Directory of Open Access Journals (Sweden)

    Wencai Zhao

    2013-01-01

    Full Text Available SIR epidemic models with distributed delay are proposed. Firstly, the dynamical behaviors of the model without vaccination are studied. Using the Jacobian matrix, the stability of the equilibrium points of the system without vaccination is analyzed. The basic reproduction number R is got. In order to study the important role of vaccination to prevent diseases, the model with distributed delay under impulsive vaccination is formulated. And the sufficient conditions of globally asymptotic stability of “infection-free” periodic solution and the permanence of the model are obtained by using Floquet’s theorem, small-amplitude perturbation skills, and comparison theorem. Lastly, numerical simulation is presented to illustrate our main conclusions that vaccination has significant effects on the dynamical behaviors of the model. The results can provide effective tactic basis for the practical infectious disease prevention.

  15. Large-scale FMO-MP3 calculations on the surface proteins of influenza virus, hemagglutinin (HA) and neuraminidase (NA)

    Science.gov (United States)

    Mochizuki, Yuji; Yamashita, Katsumi; Fukuzawa, Kaori; Takematsu, Kazutomo; Watanabe, Hirofumi; Taguchi, Naoki; Okiyama, Yoshio; Tsuboi, Misako; Nakano, Tatsuya; Tanaka, Shigenori

    2010-06-01

    Two proteins on the influenza virus surface have been well known. One is hemagglutinin (HA) associated with the infection to cells. The fragment molecular orbital (FMO) calculations were performed on a complex consisting of HA trimer and two Fab-fragments at the third-order Møller-Plesset perturbation (MP3) level. The numbers of residues and 6-31G basis functions were 2351 and 201276, and thus a massively parallel-vector computer was utilized to accelerate the processing. This FMO-MP3 job was completed in 5.8 h with 1024 processors. Another protein is neuraminidase (NA) involved in the escape from infected cells. The FMO-MP3 calculation was also applied to analyze the interactions between oseltamivir and surrounding residues in pharmacophore.

  16. Communication: A reduced scaling J-engine based reformulation of SOS-MP2 using graphics processing units

    Energy Technology Data Exchange (ETDEWEB)

    Maurer, S. A.; Kussmann, J.; Ochsenfeld, C., E-mail: Christian.Ochsenfeld@cup.uni-muenchen.de [Chair of Theoretical Chemistry, Department of Chemistry, University of Munich (LMU), Butenandtstr. 7, D-81377 München (Germany); Center for Integrated Protein Science (CIPSM) at the Department of Chemistry, University of Munich (LMU), Butenandtstr. 5–13, D-81377 München (Germany)

    2014-08-07

    We present a low-prefactor, cubically scaling scaled-opposite-spin second-order Møller-Plesset perturbation theory (SOS-MP2) method which is highly suitable for massively parallel architectures like graphics processing units (GPU). The scaling is reduced from O(N{sup 5}) to O(N{sup 3}) by a reformulation of the MP2-expression in the atomic orbital basis via Laplace transformation and the resolution-of-the-identity (RI) approximation of the integrals in combination with efficient sparse algebra for the 3-center integral transformation. In contrast to previous works that employ GPUs for post Hartree-Fock calculations, we do not simply employ GPU-based linear algebra libraries to accelerate the conventional algorithm. Instead, our reformulation allows to replace the rate-determining contraction step with a modified J-engine algorithm, that has been proven to be highly efficient on GPUs. Thus, our SOS-MP2 scheme enables us to treat large molecular systems in an accurate and efficient manner on a single GPU-server.

  17. Communication: A reduced scaling J-engine based reformulation of SOS-MP2 using graphics processing units.

    Science.gov (United States)

    Maurer, S A; Kussmann, J; Ochsenfeld, C

    2014-08-07

    We present a low-prefactor, cubically scaling scaled-opposite-spin second-order Møller-Plesset perturbation theory (SOS-MP2) method which is highly suitable for massively parallel architectures like graphics processing units (GPU). The scaling is reduced from O(N⁵) to O(N³) by a reformulation of the MP2-expression in the atomic orbital basis via Laplace transformation and the resolution-of-the-identity (RI) approximation of the integrals in combination with efficient sparse algebra for the 3-center integral transformation. In contrast to previous works that employ GPUs for post Hartree-Fock calculations, we do not simply employ GPU-based linear algebra libraries to accelerate the conventional algorithm. Instead, our reformulation allows to replace the rate-determining contraction step with a modified J-engine algorithm, that has been proven to be highly efficient on GPUs. Thus, our SOS-MP2 scheme enables us to treat large molecular systems in an accurate and efficient manner on a single GPU-server.

  18. Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation.

    Science.gov (United States)

    Kozel, Caitlin; Thompson, Brytteny; Hustak, Samantha; Moore, Chelsea; Nakashima, Akio; Singh, Chingakham Ranjit; Reid, Megan; Cox, Christian; Papadopoulos, Evangelos; Luna, Rafael E; Anderson, Abbey; Tagami, Hideaki; Hiraishi, Hiroyuki; Slone, Emily Archer; Yoshino, Ken-Ichi; Asano, Masayo; Gillaspie, Sarah; Nietfeld, Jerome; Perchellet, Jean-Pierre; Rothenburg, Stefan; Masai, Hisao; Wagner, Gerhard; Beeser, Alexander; Kikkawa, Ushio; Fleming, Sherry D; Asano, Katsura

    2016-10-14

    ATF4 is a pro-oncogenic transcription factor whose translation is activated by eIF2 phosphorylation through delayed re-initiation involving two uORFs in the mRNA leader. However, in yeast, the effect of eIF2 phosphorylation can be mimicked by eIF5 overexpression, which turns eIF5 into translational inhibitor, thereby promoting translation of GCN4, the yeast ATF4 equivalent. Furthermore, regulatory protein termed eIF5-mimic protein (5MP) can bind eIF2 and inhibit general translation. Here, we show that 5MP1 overexpression in human cells leads to strong formation of 5MP1:eIF2 complex, nearly comparable to that of eIF5:eIF2 complex produced by eIF5 overexpression. Overexpression of eIF5, 5MP1 and 5MP2, the second human paralog, promotes ATF4 expression in certain types of human cells including fibrosarcoma. 5MP overexpression also induces ATF4 expression in Drosophila The knockdown of 5MP1 in fibrosarcoma attenuates ATF4 expression and its tumor formation on nude mice. Since 5MP2 is overproduced in salivary mucoepidermoid carcinoma, we propose that overexpression of eIF5 and 5MP induces translation of ATF4 and potentially other genes with uORFs in their mRNA leaders through delayed re-initiation, thereby enhancing the survival of normal and cancer cells under stress conditions. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  19. Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine.

    Science.gov (United States)

    McILwain, R Britt; Timpa, Joseph G; Kurundkar, Ashish R; Holt, David W; Kelly, David R; Hartman, Yolanda E; Neel, Mary Lauren; Karnatak, Rajendra K; Schelonka, Robert L; Anantharamaiah, G M; Killingsworth, Cheryl R; Maheshwari, Akhil

    2010-01-01

    Extracorporeal membrane oxygenation (ECMO) is a life-saving support system used in neonates and young children with severe cardiorespiratory failure. Although ECMO has reduced mortality in these critically ill patients, almost all patients treated with ECMO develop a systemic inflammatory response syndrome (SIRS) characterized by a 'cytokine storm', leukocyte activation, and multisystem organ dysfunction. We used a neonatal porcine model of ECMO to investigate whether rising plasma concentrations of inflammatory cytokines during ECMO reflect de novo synthesis of these mediators in inflamed tissues, and therefore, can be used to assess the severity of ECMO-related SIRS. Previously healthy piglets (3-week-old) were subjected to venoarterial ECMO for up to 8 h. SIRS was assessed by histopathological analysis, measurement of neutrophil activation (flow cytometry), plasma cytokine concentrations (enzyme immunoassays), and tissue expression of inflammatory genes (PCR/western blots). Mast cell degranulation was investigated by measurement of plasma tryptase activity. Porcine neonatal ECMO was associated with systemic inflammatory changes similar to those seen in human neonates. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) concentrations rose rapidly during the first 2 h of ECMO, faster than the tissue expression of these cytokines. ECMO was associated with increased plasma mast cell tryptase activity, indicating that increased plasma concentrations of inflammatory cytokines during ECMO may result from mast cell degranulation and associated release of preformed cytokines stored in mast cells. TNF-alpha and IL-8 concentrations rose faster in plasma than in the peripheral tissues during ECMO, indicating that rising plasma levels of these cytokines immediately after the initiation of ECMO may not reflect increasing tissue synthesis of these cytokines. Mobilization of preformed cellular stores of inflammatory cytokines such as in mucosal mast cells may have

  20. Analysis of Active Lava Flows on Kilauea Volcano, Hawaii, Using SIR-C Radar Correlation Measurements

    Science.gov (United States)

    Zebker, H. A.; Rosen, P.; Hensley, S.; Mouginis-Mark, P. J.

    1995-01-01

    Precise eruption rates of active pahoehoe lava flows on Kilauea volcano, Hawaii, have been determined using spaceborne radar data acquired by the Space Shuttle Imaging Radar-C (SIR-C). Measurement of the rate of lava flow advance, and the determination of the volume of new material erupted in a given period of time, are among the most important observations that can be made when studying a volcano.

  1. Observation of $B^0_s \\to K^{*\\pm}K^\\mp$ and evidence for $B^0_s \\to K^{*-}\\pi^+$ decays

    CERN Document Server

    Aaij, Roel; Affolder, Anthony; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Anderson, Jonathan; Andreassen, Rolf; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Belogurov, Sergey; Belous, Konstantin; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Bizzeti, Andrea; Bjørnstad, Pål Marius; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borgia, Alessandra; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Brambach, Tobias; van den Brand, Johannes; Bressieux, Joël; Brett, David; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Brook, Nicholas; Brown, Henry; Bursche, Albert; Busetto, Giovanni; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Campana, Pierluigi; Campora Perez, Daniel; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Ciba, Krzystof; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cojocariu, Lucian; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Counts, Ian; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pascal; David, Pieter; Davis, Adam; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Di Canto, Angelo; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dreimanis, Karlis; Dujany, Giulio; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farley, Nathanael; Farry, Stephen; Fay, Robert; Ferguson, Dianne; Fernandez Albor, Victor; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; García Pardiñas, Julián; Garofoli, Justin; Garra Tico, Jordi; Garrido, Lluis; Gaspar, Clara; Gauld, Rhorry; Gavardi, Laura; Gavrilov, Gennadii; Geraci, Angelo; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianelle, Alessio; Giani', Sebastiana; Gibson, Valerie; Giubega, Lavinia-Helena; Gligorov, Vladimir; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Hunt, Philip; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jaton, Pierre; Jawahery, Abolhassan; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kaballo, Michael; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Karodia, Sarah; Kelsey, Matthew; Kenyon, Ian; Ketel, Tjeerd; Khanji, Basem; Khurewathanakul, Chitsanu; Klaver, Suzanne; Klimaszewski, Konrad; Kochebina, Olga; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kozlinskiy, Alexandr; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Leo, Sabato; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Lohn, Stefan; Longstaff, Iain; Lopes, Jose; Lopez-March, Neus; Lowdon, Peter; Lu, Haiting; Lucchesi, Donatella; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Machefert, Frederic; Machikhiliyan, Irina V; Maciuc, Florin; Maev, Oleg; Malde, Sneha; Malinin, Alexander; Manca, Giulia; Mancinelli, Giampiero; Mapelli, Alessandro; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Märki, Raphael; Marks, Jörg; Martellotti, Giuseppe; Martens, Aurelien; Martín Sánchez, Alexandra; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massafferri, André; Matev, Rosen; Mathe, Zoltan; Matteuzzi, Clara; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; McSkelly, Ben; Meadows, Brian; Meier, Frank; Meissner, Marco; Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Moggi, Niccolò; Molina Rodriguez, Josue; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Müller, Katharina; Mussini, Manuel; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Nicol, Michelle; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Oggero, Serena; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Orlandea, Marius; Otalora Goicochea, Juan Martin; Owen, Patrick; Oyanguren, Maria Arantza; Pal, Bilas Kanti; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parkes, Christopher; Parkinson, Christopher John; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pazos Alvarez, Antonio; Pearce, Alex; Pellegrino, Antonio; Pepe Altarelli, Monica; Perazzini, Stefano; Perez Trigo, Eliseo; Perret, Pascal; Perrin-Terrin, Mathieu; Pescatore, Luca; Pesen, Erhan; Petridis, Konstantin; Petrolini, Alessandro; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Pistone, Alessandro; Playfer, Stephen; Plo Casasus, Maximo; Polci, Francesco; Poluektov, Anton; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Price, Eugenia; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Rachwal, Bartolomiej; Rademacker, Jonas; Rakotomiaramanana, Barinjaka; Rama, Matteo; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vincente; Roa Romero, Diego; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rouvinet, Julien; Ruf, Thomas; Ruiz, Hugo; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrie, Mauro; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Seco, Marcos; Semennikov, Alexander; Sepp, Indrek; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Silva Coutinho, Rafael; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skwarnicki, Tomasz; Smith, Anthony; Smith, Edmund; Smith, Eluned; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Sparkes, Ailsa; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Steinkamp, Olaf; Stenyakin, Oleg; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Stroili, Roberto; Subbiah, Vijay Kartik; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szczypka, Paul; Szilard, Daniela; Szumlak, Tomasz; T'Jampens, Stephane; Teklishyn, Maksym; Tellarini, Giulia; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Tran, Minh Tâm; Tresch, Marco; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ubeda Garcia, Mario; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; Voss, Helge; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Whitehead, Mark; Wicht, Jean; Wiedner, Dirk; Wilkinson, Guy; Williams, Matthew; Williams, Mike; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wu, Suzhi; Wyllie, Kenneth; Xie, Yuehong; Xing, Zhou; Xu, Zhirui; Yang, Zhenwei; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Wen Chao; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang; Zvyagin, Alexander

    2014-01-01

    Measurements of the branching fractions of $B^0_{(s)} \\to K^{*\\pm}K^\\mp$ and $B^0_{(s)} \\to K^{*\\pm}\\pi^\\mp$ decays are performed using a data sample corresponding to $1.0 \\ {\\rm fb}^{-1}$ of proton-proton collision data collected with the LHCb detector at a centre-of-mass energy of $7\\mathrm{\\,TeV}$, where the $K^{*\\pm}$ mesons are reconstructed in the $K^0_{\\rm S}\\pi^\\pm$ final state. The first observation of the $B^0_s \\to K^{*\\pm}K^\\mp$ decay and the first evidence for the $B^0_s \\to K^{*-}\\pi^+$ decay are reported with branching fractions \\begin{eqnarray} {\\cal B}\\left(B^0_s \\to K^{*\\pm}K^\\mp\\right) & = & \\left( 12.7\\pm1.9\\pm1.9 \\right) \\times 10^{-6} \\, , \\\\ {\\cal B}\\left(B^0_s \\to K^{*-}\\pi^+\\right) & = & ~\\left( 3.3\\pm1.1\\pm0.5 \\right) \\times 10^{-6} \\, , \\end{eqnarray} where the first uncertainties are statistical and the second are systematic. In addition, an upper limit of ${\\cal B}\\left(B^0 \\to K^{*\\pm}K^\\mp\\right) < 0.4 \\ (0.5) \\times 10^{-6}$ is set at $90\\,\\% \\ (95\\,\\%)$ conf...

  2. Resolution of the Identity and Cholesky Representation of EOM-MP2 ...

    Indian Academy of Sciences (India)

    Dinesh Kumar

    2017-10-23

    Oct 23, 2017 ... like excitation energy (EE), ionization energy (IP) and electron affinity (EA). ... the method would lead to loss of size-extensivity unless an appropriate .... technique74 can avoid the four-particle integrals in EOM-. EA-MP2 ..... the sigma vector update procedure should be three times faster in the canonical ...

  3. Moniliophthora perniciosa necrosis- and ethylene-inducing protein 2 (MpNep2 as a metastable dimer in solution: structural and functional implications.

    Directory of Open Access Journals (Sweden)

    Guilherme A P de Oliveira

    Full Text Available Understanding how Nep-like proteins (NLPs behave during the cell cycle and disease progression of plant pathogenic oomycetes, fungi and bacteria is crucial in light of compelling evidence that these proteins play a role in Witches` Broom Disease (WBD of Theobroma cacao, one of the most important phytopathological problems to afflict the Southern Hemisphere. The crystal structure of MpNep2, a member of the NLP family and the causal agent of WBD, revealed the key elements for its activity. This protein has the ability to refold after heating and was believed to act as a monomer in solution, in contrast to the related homologs MpNep1 and NPP from the oomyceteous fungus Phytophthora parasitica. Here, we identify and characterize a metastable MpNep2 dimer upon over-expression in Escherichia coli using different biochemical and structural approaches. We found using ultra-fast liquid chromatography that the MpNep2 dimer can be dissociated by heating but not by dilution, oxidation or high ionic strength. Small-angle X-ray scattering revealed a possible tail-to-tail interaction between monomers, and nuclear magnetic resonance measurements identified perturbed residues involved in the putative interface of interaction. We also explored the ability of the MpNep2 monomer to refold after heating or chemical denaturation. We observed that MpNep2 has a low stability and cooperative fold that could be an explanation for its structure and activity recovery after stress. These results can provide new insights into the mechanism for MpNep2's action in dicot plants during the progression of WBD and may open new avenues for the involvement of NLP- oligomeric species in phytopathological disorders.

  4. The use of median polish (MP) for the daily quality assurance of a multiplanar positron emission tomography (PET)

    International Nuclear Information System (INIS)

    Kearfott, K.J.; Thaler, H.T.; Dukes, A.L.; Carmichael, P.G.

    1984-01-01

    Daily sensitivity data were obtained for The Cyclotron Corporation PC 4600 Neuro-PET on an almost daily basis for 3 months during installation and for 6 months during full clinical utilization. A uniform phantom was filled with a known concentration of isotope (typically 0.14 μCi/cc Ga-68), centered in the scanner port using crossed lasers and scanned. Images were reconstructed using analytic attenuation correction for a total of 4-5 million uncorrected coincidence counts/plane (random/true <2%). The entire quality assurance procedure, with analysis, was performed within 1.5 hr. The resulting sensitivities for various planes and days can be represented as a two-way table. Median polish (MP) is a statistically robust technique for looking at structured or cross-classified data to identify trends and outliers by iteratively computing medians of rows and columns in order to obtain a linear fit to the data. Outliers (both for variant planes, experiments and combinations) were immediately discernible when MP was used to analyze the sensitivity data. While the standard deviations of the residuals in the MP table ranged from 2.1% to 18.5% during machine installation, subsequent variations were smaller (0.6-4.2%), and the number of outliers was substantially reduced. In addition, MP was useful in pointing out a sudden change in machine behavior related to a high-voltage power supply problem. Systematic drifts in sensitivity and reliability of both individual planes and of the entire machine are readily revealed by MP, which is therefore very useful in monitoring performance and in directing maintenance

  5. OpenMP Issues Arising in the Development of Parallel BLAS and LAPACK Libraries

    Directory of Open Access Journals (Sweden)

    C. Addison

    2003-01-01

    Full Text Available Dense linear algebra libraries need to cope efficiently with a range of input problem sizes and shapes. Inherently this means that parallel implementations have to exploit parallelism wherever it is present. While OpenMP allows relatively fine grain parallelism to be exploited in a shared memory environment it currently lacks features to make it easy to partition computation over multiple array indices or to overlap sequential and parallel computations. The inherent flexible nature of shared memory paradigms such as OpenMP poses other difficulties when it becomes necessary to optimise performance across successive parallel library calls. Notions borrowed from distributed memory paradigms, such as explicit data distributions help address some of these problems, but the focus on data rather than work distribution appears misplaced in an SMP context.

  6. Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2.

    Science.gov (United States)

    Bheda, Poonam; Swatkoski, Stephen; Fiedler, Katherine L; Boeke, Jef D; Cotter, Robert J; Wolberger, Cynthia

    2012-04-17

    Although the biological roles of many members of the sirtuin family of lysine deacetylases have been well characterized, a broader understanding of their role in biology is limited by the challenges in identifying new substrates. We present here an in vitro method that combines biotinylation and mass spectrometry (MS) to identify substrates deacetylated by sirtuins. The method permits labeling of deacetylated residues with amine-reactive biotin on the ε-nitrogen of lysine. The biotin can be utilized to purify the substrate and identify the deacetylated lysine by MS. The biotinyl-lysine method was used to compare deacetylation of chemically acetylated histones by the yeast sirtuins, Sir2 and Hst2. Intriguingly, Sir2 preferentially deacetylates histone H3 lysine 79 as compared to Hst2. Although acetylation of K79 was not previously reported in Saccharomyces cerevisiae, we demonstrate that a minor population of this residue is indeed acetylated in vivo and show that Sir2, and not Hst2, regulates the acetylation state of H3 lysine 79. The in vitro biotinyl-lysine method combined with chemical acetylation made it possible to identify this previously unknown, low-abundance histone acetyl modification in vivo. This method has further potential to identify novel sirtuin deacetylation substrates in whole cell extracts, enabling large-scale screens for new deacetylase substrates.

  7. An Ab Initio MP2 Study of HCN-HX Hydrogen Bonded Complexes

    Directory of Open Access Journals (Sweden)

    Araújo Regiane C.M.U.

    1998-01-01

    Full Text Available An ab initio MP2/6-311++G** study has been performed to obtain geometries, binding energies and vibrational properties of HCN-HX H-bonded complexes with X = F, Cl, NC, CN and CCH. These MP2/6-311++G** results have revealed that: (i the calculated H-bond lengths are in very good agreement with the experimental ones; (ii the H-bond strength is associated with the intermolecular charge transfer and follows the order: HCN-HNC ~ HCN-HF > HCN-HCl ~ HCN-HCN > HCN-HCCH; (iii BSSE correction introduces an average reduction of 2.4 kJ/mol on the MP2/6-311++G** binding energies, i.e. 11% of the uncorrected binding energy; (iv the calculated zero-point energies reduce the stability of these complexes and show a good agreement with the available experimental values; (v the H-X stretching frequency is shifted downward upon H-bond formation. This displacement is associated with the H-bond length; (vi The more pronounced effect on the infrared intensities occurs with the H-X stretching intensity. It is much enhanced after complexation due to the charge-flux term; (vii the calculated intermolecular stretching frequencies are in very good agreement with the experimental ones; and, finally, (viii the results obtained for the HCN-HX complexes follow the same profile as those found for the acetylene-HX series but, in the latter case, the effects on the properties of the free molecules due to complexation are less pronounced than those in HCN-HX.

  8. A comparison between cervical vertebrae and modified MP3 stages for the assessment of skeletal maturity.

    Science.gov (United States)

    Prasad, Mandava; Ganji, Venkata Suresh Kumar; George, Suja Ani; Talapaneni, Ashok Kumar; Shetty, Sharath Kumar

    2013-01-01

    Evaluation of skeletal maturity in human individuals is an important aspect in orthodontics and dentofacial orthopedics because, growth guidance and fundamental structural changes are essential for treatment of skeletal discrepancies in all the three planes. Among various growth assessment methods, cervical vertebra maturation stages and hand wrist have been correlated with the individual growth changes during puberty. The purpose of this study is to determine correlation of the CVM index with the modified median phalanx index (MP3) as described by Rajagopal and Kansal. 200 subjects (100 males and 100 females) of Nellore, Indian origin boys aged between 10 to 19 years and girls of 8 to 16 years were selected for the study. The subjects are selected randomly from patients visiting the Departments of Orthodontics and Dentofacial Orthopedics, Pediatric dentistry and Oral medicine and Radiology at Narayana Dental College and Hospital. Nellore. Radiographs of left hand MP3 and lateral cephalogram were taken. Cohen's kappa statistic was used to assess the agreement between the two measurements based on categorical variables. There was a good concordance between 6 stages of CVMI (Hassel and Farman) and the 6 stages of MP3 (Rajagopal and Kansal). Physiological maturity was earlier in females than in males when compared to the individuals of opposite sex of same chronological age. Chronological age was not a valid predictor of assessing the skeletal maturity because of significant variations in the distribution of CVMI and MP3 stages with respect to individual chronological age distribution.

  9. A recognizable systemic connective tissue disorder with polyvalvular heart dystrophy and dysmorphism associated with TAB2 mutations.

    Science.gov (United States)

    Ritelli, M; Morlino, S; Giacopuzzi, E; Bernardini, L; Torres, B; Santoro, G; Ravasio, V; Chiarelli, N; D'Angelantonio, D; Novelli, A; Grammatico, P; Colombi, M; Castori, M

    2018-01-01

    Deletions encompassing TAK1-binding protein 2 (TAB2) associated with isolated and syndromic congenital heart defects. Rare missense variants are found in patients with a similar phenotype as well as in a single individual with frontometaphyseal dysplasia. We describe a family and an additional sporadic patient with polyvalvular heart disease, generalized joint hypermobility and related musculoskeletal complications, soft, velvety and hyperextensible skin, short limbs, hearing impairment, and facial dysmorphism. In the first family, whole-exome sequencing (WES) disclosed the novel TAB2 c.1398dup (p.Thr467Tyrfs*6) variant that eliminates the C-terminal zinc finger domain essential for activation of TAK1 (TGFβ-activated kinase 1)-dependent signaling pathways. The sporadic case carryed a ~2 Mb de novo deletion including 28 genes also comprising TAB2. This study reveal an association between TAB2 mutations and a phenotype resembling Ehlers-Danlos syndrome with severe polyvalvular heart disease and subtle facial dysmorphism. Our findings support the existence of a wider spectrum of clinical phenotypes associated with TAB2 perturbations and emphasize the role of TAK1 signaling network in human development. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. Influence of the solution pH in the 6-mercaptopurine self-assembled monolayer (6MP-SAM) on a Au(111) single-crystal electrode.

    Science.gov (United States)

    Madueño, Rafael; García-Raya, Daniel; Viudez, Alfonso J; Sevilla, José M; Pineda, Teresa; Blázquez, Manuel

    2007-10-23

    Self-assembled monolayers (SAMs) of 6-mercaptopurine (6MP) have been prepared on a Au(111) single-crystal electrode by immersion of the metal surface in a 100 microM 6MP and 0.01 M HClO4 solution. The 6MP-SAM Au(111) single-crystal electrodes were transferred to the cell and allowed to equilibrate with the different aqueous working solutions before the electrochemical experiments. The influence of the solution pH was studied by cyclic voltammetry, double layer capacitance curves, and electrochemical impedance spectroscopy. The electrochemical behavior of the 6MP-SAM in acetic acid at pH 4 presents important differences in comparison to that obtained in 0.1 M KOH solutions. Cyclic voltammograms for the reductive desorption process in acid medium are broad and show some features that can be explained by a phase transition between a chemisorbed and a physisorbed state of the 6MP molecules. The low solubility of these molecules in acid medium could explain this phenomenon and the readsorption of the complete monolayer when the potential is scanned in the positive direction. The variation of the double-layer capacitance values in the potential range of monolayer stability with the pH suggests that the acid-base chemistry of the 6MP molecules is playing a role. This fact has been studied by following the variations of the electron-transfer rate constant of the highly charged redox probes as are Fe(CN)(6)-3/-4 and Ru(NH3)(6)+3/+2 as a function of solution pH. The apparent surface pKa value for the 6MP-SAM (pKa approximately 8) is explained by the total conversion of the different 6MP tautomers that exist in solution to the thiol species in the adsorbed state.

  11. Muuga söeterminal töötab lubadeta / Urmas Tooming

    Index Scriptorium Estoniae

    Tooming, Urmas

    2005-01-01

    Kuigi keskkonnainspektsioon karistas Muuga söeterminalis tegutsevat AS-i Coal Terminal Operator välisõhu kaitse ja veeseaduse rikkumise eest kokku 33 000 krooni suuruse trahviga ja kohustas firmat lõpetama saasteainete keskkonda paiskamise, töötab kasutus- ja keskkonnalubadeta ettevõte edasi

  12. Low energy isomers of (H2O)25 from a hierarchical method based on Monte Carlo temperature basin paving and molecular tailoring approaches benchmarked by MP2 calculations

    International Nuclear Information System (INIS)

    Sahu, Nityananda; Gadre, Shridhar R.; Rakshit, Avijit; Bandyopadhyay, Pradipta; Miliordos, Evangelos; Xantheas, Sotiris S.

    2014-01-01

    We report new global minimum candidate structures for the (H 2 O) 25 cluster that are lower in energy than the ones reported previously and correspond to hydrogen bonded networks with 42 hydrogen bonds and an interior, fully coordinated water molecule. These were obtained as a result of a hierarchical approach based on initial Monte Carlo Temperature Basin Paving sampling of the cluster's Potential Energy Surface with the Effective Fragment Potential, subsequent geometry optimization using the Molecular Tailoring Approach with the fragments treated at the second order Møller-Plesset (MP2) perturbation (MTA-MP2) and final refinement of the entire cluster at the MP2 level of theory. The MTA-MP2 optimized cluster geometries, constructed from the fragments, were found to be within 2 O) 25 cluster. In addition, the grafting of the MTA-MP2 energies yields electronic energies that are within <0.3 kcal/mol from the MP2 energies of the entire cluster while preserving their energy rank order. Finally, the MTA-MP2 approach was found to reproduce the MP2 harmonic vibrational frequencies, constructed from the fragments, quite accurately when compared to the MP2 ones of the entire cluster in both the HOH bending and the OH stretching regions of the spectra

  13. A modified CoSaMP algorithm for electromagnetic imaging of two dimensional domains

    KAUST Repository

    Sandhu, Ali Imran; Bagci, Hakan

    2017-01-01

    The compressive sampling matching pursuit (CoSaMP) algorithm is used for solving the electromagnetic inverse scattering problem on two-dimensional sparse domains. Since the scattering matrix, which is computed by sampling the Green function, does

  14. Troposphere - ionosphere interaction during tropospheric MCC events

    International Nuclear Information System (INIS)

    Manzano, J.R.; Zossi Artigas, M.M. de; Filippi Manzano, A.N. de; Cosio Ragone, A.H. de

    1995-09-01

    The present paper describes the investigation of possible effects of the type of large meteorological events known as Mesoscale Convective Complexes (MCC) on the F-region of the ionosphere over Argentina. These warm-season weather systems of huge size are present in the United States (Maddox, 1980) and in South Americal (Velasco and Fritsch, 1987). Their extension can be as large as 1,300,000 Km 2 and they tend to move in different directions over the earth surface. It is expected that these meteorological events should leave its signature in the upper region of the atmosphere. 13 refs, 12 figs, 1 tab

  15. MP-12 virus containing the clone 13 deletion in the NSs gene prevents lethal disease when administered after Rift Valley fever virus infection in hamsters.

    Science.gov (United States)

    Gowen, Brian B; Westover, Jonna B; Sefing, Eric J; Bailey, Kevin W; Nishiyama, Shoko; Wandersee, Luci; Scharton, Dionna; Jung, Kie-Hoon; Ikegami, Tetsuro

    2015-01-01

    Rift Valley fever virus (RVFV; Bunyaviridae, Phlebovirus) causes a range of illnesses that include retinitis, fulminant hepatitis, neurologic disease, and hemorrhagic fever. In hospitalized individuals, case fatality rates can be as high as 10-20%. There are no vaccines or antivirals approved for human use to prevent or treat severe RVFV infections. We previously tested the efficacy of the MP-12 vaccine strain and related variants with NSs truncations as a post-exposure prophylaxis in mice infected with wild-type pathogenic RVFV strain ZH501. Post-exposure efficacy of the rMP12-C13type, a recombinant MP-12 vaccine virus which encodes an in-frame truncation removing 69% of the NSs protein, resulted in 30% survival when administering the virus within 30 min of subcutaneous ZH501 challenge in mice, while the parental MP-12 virus conferred no protection by post-exposure vaccination. Here, we demonstrate uniform protection of hamsters by post-exposure vaccination with rMP12-C13type administered 6 h post-ZH501 infection while no efficacy was observed with the parental MP-12 virus. Notably, both the MP-12 and rMP12-C13type viruses were highly effective (100% protection) when administered 21 days prior to challenge. In a subsequent study delaying vaccination until 8, 12, and 24 h post-RVFV exposure, we observed 80, 70, and 30% survival, respectively. Our findings indicate that the rapid protective innate immune response elicited by rMP12-C13type may be due to the truncated NSs protein, suggesting that the resulting functional inactivation of NSs plays an important role in the observed post-exposure efficacy. Taken together, the data demonstrate that post-exposure vaccination with rMP12-C13type is effective in limiting ZH501 replication and associated disease in standard pre-exposure vaccination and post-challenge treatment models of RVFV infection, and suggest an extended post-exposure prophylaxis window beyond that initially observed in mice.

  16. A stochastic SIRS epidemic model with infectious force under intervention strategies

    Science.gov (United States)

    Cai, Yongli; Kang, Yun; Banerjee, Malay; Wang, Weiming

    2015-12-01

    In this paper, we extend a classical SIRS epidemic model with the infectious forces under intervention strategies from a deterministic framework to a stochastic differential equation (SDE) one through introducing random fluctuations. The value of our study lies in two aspects. Mathematically, by using the Markov semigroups theory, we prove that the reproduction number R0S can be used to govern the stochastic dynamics of SDE model. If R0S 1, under mild extra conditions, it has an endemic stationary distribution which leads to the stochastical persistence of the disease. Epidemiologically, we find that random fluctuations can suppress disease outbreak, which can provide us some useful control strategies to regulate disease dynamics.

  17. Sir Charles Bell (1774-1842) and his contributions to early neurosurgery.

    Science.gov (United States)

    Tubbs, R Shane; Riech, Sheryl; Verma, Ketan; Mortazavi, Martin M; Loukas, Marios; Benninger, Brion; Cohen-Gadol, Aaron A

    2012-03-01

    The renowned surgeon, neuroanatomist, and artist Sir Charles Bell not only impacted the lives of his peers through his creative endeavors and passion for art, but also sparked noteworthy breakthroughs in the field of neuroscience. His empathetic nature and zest for life enabled him to develop an early proclivity for patient care. As a result of his innovative findings regarding sensory and motor nerves and the anatomical makeup of the brain, he accepted some of the most prestigious awards and received an honorable reputation in society. Bell is recognized for his diligence, perseverance, and his remarkable contributions to surgery. The present review will explore his contributions to the discipline now known as neurosurgery.

  18. Maurice Couturier. Nabokov ou la cruauté du désir.

    Directory of Open Access Journals (Sweden)

    René Alladaye

    2006-04-01

    Full Text Available La lecture peut avoir partie liée avec la transgression. Maurice Couturier en apporte la preuve dans son dernier ouvrage, Nabokov ou la cruauté du désir, en enfreignant l’un des plus célèbres interdits nabokoviens, celui de la lecture psychanalytique de son œuvre. On se souvient des préfaces des romans où l’auteur ne se fait jamais faute de décourager la moindre velléité freudienne et d’une réponse des plus tranchantes administrée dans le cadre d’un entretien : « Laissons les crédules et les ...

  19. Deadly Throwaways--Plastic Six-Pack Binders and Metal Pull-Tabs Doom Wildlife

    Science.gov (United States)

    Ward, Penny

    1975-01-01

    Thousands of creatures are vulnerable to entrapment, entanglement, strangulation, or starvation as a result of plastic six-pack binders and metal pull-tabs. Possible solutions include: recycling, clean-up campaigns, and strong container legislation. (BT)

  20. G3(MP2)-CEP theory and applications for compounds containing atoms from representative first, second and third row elements of the periodic table.

    Science.gov (United States)

    Pereira, Douglas Henrique; Rocha, Carlos Murilo Romero; Morgon, Nelson Henrique; Custodio, Rogério

    2015-08-01

    The compact effective potential (CEP) pseudopotential was adapted to the G3(MP2) theory, herein referred to as G3(MP2)-CEP, and applied to the calculation of enthalpies of formation, ionization energies, atomization energies, and electron and proton affinities for 446 species containing elements of the 1st, 2nd, and 3rd rows of the periodic table. A total mean absolute deviation of 1.67 kcal mol(-1) was achieved with G3(MP2)-CEP, compared with 1.47 kcal mol(-1) for G3(MP2). Electron affinities and enthalpies of formation are the properties exhibiting the lowest deviations with respect to the original G3(MP2) theory. The use of pseudopotentials and composite theories in the framework of the G3 theory is feasible and compatible with the all electron approach. Graphical Abstract Application of composite methods in high-level ab initio calculations.

  1. Position Paper: OpenMP scheduling on ARM big.LITTLE architecture

    OpenAIRE

    Butko , Anastasiia; Bessad , Louisa; Novo , David; Bruguier , Florent; Gamatié , Abdoulaye; Sassatelli , Gilles; Torres , Lionel; Robert , Michel

    2016-01-01

    International audience; Single-ISA heterogeneous multicore systems are emerging as a promising direction to achieve a more suitable balance between performance and energy consumption. However, a proper utilization of these architectures is essential to reach the energy benefits. In this paper, we demonstrate the ineffectiveness of popular OpenMP scheduling policies executing Rodinia benchmark on the Exynos 5 Octa (5422) SoC, which integrates the ARM big.LITTLE architecture.

  2. Genes ycfR, sirA and yigG contribute to the surface attachment of Salmonella enterica Typhimurium and Saintpaul to fresh produce.

    Directory of Open Access Journals (Sweden)

    Joelle K Salazar

    Full Text Available Salmonella enterica is a frequent contaminant of minimally-processed fresh produce linked to major foodborne disease outbreaks. The molecular mechanisms underlying the association of this enteric pathogen with fresh produce remain largely unexplored. In our recent study, we showed that the expression of a putative stress regulatory gene, ycfR, was significantly induced in S. enterica upon exposure to chlorine treatment, a common industrial practice for washing and decontaminating fresh produce during minimal processing. Two additional genes, sirA involved in S. enterica biofilm formation and yigG of unknown function, were also found to be differentially regulated under chlorine stress. To further characterize the roles of ycfR, sirA, and yigG in S. enterica attachment and survival on fresh produce, we constructed in-frame deletions of all three genes in two different S. enterica serovars, Typhimurium and Saintpaul, which have been implicated in previous disease outbreaks linked to fresh produce. Bacterial attachment to glass and polystyrene microtiter plates, cell aggregation and hydrophobicity, chlorine resistance, and surface attachment to intact spinach leaf and grape tomato were compared among wild-type strains, single-gene deletion mutants, and their respective complementation mutants. The results showed that deletions of ycfR, sirA, and yigG reduced bacterial attachment to glass and polystyrene as well as fresh produce surface with or without chlorine treatment in both Typhimurium and Saintpaul. Deletion of ycfR in Typhimurium significantly reduced bacterial chlorine resistance and the attachment to the plant surfaces after chlorinated water washes. Deletions of ycfR in Typhimurium and yigG in Saintpaul resulted in significant increase in cell aggregation. Our findings suggest that ycfR, sirA, and yigG collectively contribute to S. enterica surface attachment and survival during post-harvest minimal processing of fresh produce.

  3. Insight into Potential Probiotic Markers Predicted in Lactobacillus pentosus MP-10 Genome Sequence

    Directory of Open Access Journals (Sweden)

    Hikmate Abriouel

    2017-05-01

    Full Text Available Lactobacillus pentosus MP-10 is a potential probiotic lactic acid bacterium originally isolated from naturally fermented Aloreña green table olives. The entire genome sequence was annotated to in silico analyze the molecular mechanisms involved in the adaptation of L. pentosus MP-10 to the human gastrointestinal tract (GIT, such as carbohydrate metabolism (related with prebiotic utilization and the proteins involved in bacteria–host interactions. We predicted an arsenal of genes coding for carbohydrate-modifying enzymes to modify oligo- and polysaccharides, such as glycoside hydrolases, glycoside transferases, and isomerases, and other enzymes involved in complex carbohydrate metabolism especially starch, raffinose, and levan. These enzymes represent key indicators of the bacteria’s adaptation to the GIT environment, since they involve the metabolism and assimilation of complex carbohydrates not digested by human enzymes. We also detected key probiotic ligands (surface proteins, excreted or secreted proteins involved in the adhesion to host cells such as adhesion to mucus, epithelial cells or extracellular matrix, and plasma components; also, moonlighting proteins or multifunctional proteins were found that could be involved in adhesion to epithelial cells and/or extracellular matrix proteins and also affect host immunomodulation. In silico analysis of the genome sequence of L. pentosus MP-10 is an important initial step to screen for genes encoding for proteins that may provide probiotic features, and thus provides one new routes for screening and studying this potentially probiotic bacterium.

  4. MP-AzeFlu provides rapid and effective allergic rhinitis control: results of a non-interventional study in Romania.

    Science.gov (United States)

    Agache, I; Doros, I C; Leru, P M; Bucur, I; Poenaru, M; Sarafoleanu, C

    2018-03-01

    Allergic Rhinitis and its Impact on Asthma (ARIA) and the European Union (EU) recommend a shift to guide allergic rhinitis (AR) treatment decisions from symptom severity to disease control, using a simple visual analogue scale (VAS). Using this VAS we assessed, in a real-life study in Romania, the effectiveness of MP-AzeFlu nasal spray. In this multi-centre, prospective, non-interventional study, 253 patients (over 11 years old) with moderate-to-severe AR were prescribed MP-AzeFlu and assessed their symptoms on a VAS (0 (not at all bothersome) to 100 mm (very bothersome)) on Days 0, 1, 3, 7 and 14. The proportion of patients who achieved a defined VAS score cut-off for well-controlled (38 mm) AR were also calculated. Patients perception of disease control was assessed on Day 3. MP-AzeFlu use was associated with a mean (standard deviation) VAS score reduction from 78.4 (15.1) mm at baseline to 14.7 (15.1) mm on the last day. Effectiveness was consistent irrespective of disease severity, phenotype or patient age. 83.4% of patients achieved the smaller than 39 mm well-controlled VAS score cut-off by last day and 95.2% considered their symptoms to be well- or partly controlled at Day 3. MP-AzeFlu provided rapid, effective and sustained AR symptom control in a real-life setting in Romania, irrespective of severity, phenotype or patient age, aligning with ARIA and EU recommendations and supporting the position of MP-AzeFlu as the drug of choice for the treatment of moderate-to-severe AR.

  5. Docking, thermodynamics and molecular dynamics (MD) studies of a non-canonical protease inhibitor, MP-4, from Mucuna pruriens.

    Science.gov (United States)

    Kumar, Ashish; Kaur, Harmeet; Jain, Abha; Nair, Deepak T; Salunke, Dinakar M

    2018-01-12

    Sequence and structural homology suggests that MP-4 protein from Mucuna pruriens belongs to Kunitz-type protease inhibitor family. However, biochemical assays showed that this protein is a poor inhibitor of trypsin. To understand the basis of observed poor inhibition, thermodynamics and molecular dynamics (MD) simulation studies on binding of MP-4 to trypsin were carried out. Molecular dynamics simulations revealed that temperature influences the spectrum of conformations adopted by the loop regions in the MP-4 structure. At an optimal temperature, MP-4 achieves maximal binding while above and below the optimum temperature, its functional activity is hampered due to unfavourable flexibility and relative rigidity, respectively. The low activity at normal temperature is due to the widening of the conformational spectrum of the Reactive Site Loop (RSL) that reduces the probability of formation of stabilizing contacts with trypsin. The unique sequence of the RSL enhances flexibility at ambient temperature and thus reduces its ability to inhibit trypsin. This study shows that temperature influences the function of a protein through modulation in the structure of functional domain of the protein. Modulation of function through appearance of new sequences that are more sensitive to temperature may be a general strategy for evolution of new proteins.

  6. Driving error and anxiety related to iPod mp3 player use in a simulated driving experience.

    Science.gov (United States)

    Harvey, Ashley R; Carden, Randy L

    2009-08-01

    Driver distraction due to cellular phone usage has repeatedly been shown to increase the risk of vehicular accidents; however, the literature regarding the use of other personal electronic devices while driving is relatively sparse. It was hypothesized that the usage of an mp3 player would result in an increase in not only driving error while operating a driving simulator, but driver anxiety scores as well. It was also hypothesized that anxiety scores would be positively related to driving errors when using an mp3 player. 32 participants drove through a set course in a driving simulator twice, once with and once without an iPod mp3 player, with the order counterbalanced. Number of driving errors per course, such as leaving the road, impacts with stationary objects, loss of vehicular control, etc., and anxiety were significantly higher when an iPod was in use. Anxiety scores were unrelated to number of driving errors.

  7. The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development

    Science.gov (United States)

    2011-01-01

    Background Mitogen-activated protein kinase (MAPK) cascades (p38, JNK, ERK pathways) are involved in cell fate acquisition during development. These kinase modules are associated with scaffold proteins that control their activity. In Drosophila, dMP1, that encodes an ERK scaffold protein, regulates ERK signaling during wing development and contributes to intervein and vein cell differentiation. Functional relationships during wing development between a chromatin regulator, the Enhancer of Trithorax and Polycomb Corto, ERK and its scaffold protein dMP1, are examined here. Results Genetic interactions show that corto and dMP1 act together to antagonize rolled (which encodes ERK) in the future intervein cells, thus promoting intervein fate. Although Corto, ERK and dMP1 are present in both cytoplasmic and nucleus compartments, they interact exclusively in nucleus extracts. Furthermore, Corto, ERK and dMP1 co-localize on several sites on polytene chromosomes, suggesting that they regulate gene expression directly on chromatin. Finally, Corto is phosphorylated. Interestingly, its phosphorylation pattern differs between cytoplasm and nucleus and changes upon ERK activation. Conclusions Our data therefore suggest that the Enhancer of Trithorax and Polycomb Corto could participate in regulating vein and intervein genes during wing tissue development in response to ERK signaling. PMID:21401930

  8. The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development.

    Science.gov (United States)

    Mouchel-Vielh, Emmanuèle; Rougeot, Julien; Decoville, Martine; Peronnet, Frédérique

    2011-03-14

    Mitogen-activated protein kinase (MAPK) cascades (p38, JNK, ERK pathways) are involved in cell fate acquisition during development. These kinase modules are associated with scaffold proteins that control their activity. In Drosophila, dMP1, that encodes an ERK scaffold protein, regulates ERK signaling during wing development and contributes to intervein and vein cell differentiation. Functional relationships during wing development between a chromatin regulator, the Enhancer of Trithorax and Polycomb Corto, ERK and its scaffold protein dMP1, are examined here. Genetic interactions show that corto and dMP1 act together to antagonize rolled (which encodes ERK) in the future intervein cells, thus promoting intervein fate. Although Corto, ERK and dMP1 are present in both cytoplasmic and nucleus compartments, they interact exclusively in nucleus extracts. Furthermore, Corto, ERK and dMP1 co-localize on several sites on polytene chromosomes, suggesting that they regulate gene expression directly on chromatin. Finally, Corto is phosphorylated. Interestingly, its phosphorylation pattern differs between cytoplasm and nucleus and changes upon ERK activation. Our data therefore suggest that the Enhancer of Trithorax and Polycomb Corto could participate in regulating vein and intervein genes during wing tissue development in response to ERK signaling.

  9. The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development

    Directory of Open Access Journals (Sweden)

    Peronnet Frédérique

    2011-03-01

    Full Text Available Abstract Background Mitogen-activated protein kinase (MAPK cascades (p38, JNK, ERK pathways are involved in cell fate acquisition during development. These kinase modules are associated with scaffold proteins that control their activity. In Drosophila, dMP1, that encodes an ERK scaffold protein, regulates ERK signaling during wing development and contributes to intervein and vein cell differentiation. Functional relationships during wing development between a chromatin regulator, the Enhancer of Trithorax and Polycomb Corto, ERK and its scaffold protein dMP1, are examined here. Results Genetic interactions show that corto and dMP1 act together to antagonize rolled (which encodes ERK in the future intervein cells, thus promoting intervein fate. Although Corto, ERK and dMP1 are present in both cytoplasmic and nucleus compartments, they interact exclusively in nucleus extracts. Furthermore, Corto, ERK and dMP1 co-localize on several sites on polytene chromosomes, suggesting that they regulate gene expression directly on chromatin. Finally, Corto is phosphorylated. Interestingly, its phosphorylation pattern differs between cytoplasm and nucleus and changes upon ERK activation. Conclusions Our data therefore suggest that the Enhancer of Trithorax and Polycomb Corto could participate in regulating vein and intervein genes during wing tissue development in response to ERK signaling.

  10. FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PEMBERIAN MP-ASI PADA BAYI USIA 0-6 BULAN DI BPM NURTILA PALEMBANG

    OpenAIRE

    Rahmalia Afriyani; Shintya Halisa; Hetty Rolina

    2016-01-01

    WHO dan UNICEFmerekomendasikan standar emas pemberian makan pada bayi  yaitu  menyusui bayi secara eksklusif sejak lahir sampai dengan umur 6 bulan didahului dengan Inisiasi Menyusu Dini (IMD) segera setelah lahir, mulai umur 6 bulan berikan Makanan Pendamping ASI (MP-ASI). Tujuan penelitian ini adalah diketahuinya faktor-faktor yang berhubungan dengan pemberian MP-ASI pada bayi usia 0-6 bulan di BPM Nurtila Palembang tahun 2016.Desain penelitian kuantitatif bersifat survei analitik dengan pe...

  11. Comparision of ICP-OES and MP-AES in determing soil nutrients by Mechlich3 method

    Science.gov (United States)

    Tonutare, Tonu; Penu, Priit; Krebstein, Kadri; Rodima, Ako; Kolli, Raimo; Shanskiy, Merrit

    2014-05-01

    Accurate, routine testing of nutrients in soil samples is critical to understanding soil potential fertility. There are different factors which must be taken into account selecting the best analytical technique for soil laboratory analysis. Several techniques can provide adequate detection range for same analytical subject. In similar cases the choise of technique will depend on factors such as sample throughput, required infrastructure, ease of use, used chemicals and need for gas supply and operating costs. Mehlich 3 extraction method is widely used for the determination of the plant available nutrient elements contents in agricultural soils. For determination of Ca, K, and Mg from soil extract depending of laboratory ICP and AAS techniques are used, also flame photometry for K in some laboratories. For the determination of extracted P is used ICP or Vis spectrometry. The excellent sensitivity and wide working range for all extracted elements make ICP a nearly ideal method, so long as the sample throughput is big enough to justify the initial capital outlay. Other advantage of ICP techniques is the multiplex character (simultaneous acquisition of all wavelengths). Depending on element the detection limits are in range 0.1 - 1000 μg/L. For smaller laboratories with low sample throughput requirements the use of AAS is more common. Flame AAS is a fast, relatively cheap and easy technique for analysis of elements. The disadvantages of the method is single element analysis and use of flammable gas, like C2H2 and oxidation gas N2O for some elements. Detection limits of elements for AAS lays from 1 to 1000 μg/L. MP-AES offers a unique alternative to both, AAS and ICP-OES techniques with its detection power, speed of analysis. MP-AES is quite new, simple and relatively inexpensive multielemental technique, which is use self-sustained atmospheric pressure microwave plasma (MP) using nitrogen gas generated by nitrogen generator. Therefore not needs for argon and

  12. Low temperature physical properties of Co-35Ni-20Cr-10Mo alloy MP35N®

    Science.gov (United States)

    Lu, J.; Toplosky, V. J.; Goddard, R. E.; Han, K.

    2017-09-01

    Multiphase Co-35Ni-20Cr-10Mo alloy MP35N® is a high strength alloy with excellent corrosion resistance. Its applications span chemical, medical, and food processing industries. Thanks to its high modulus and high strength, it found applications in reinforcement of ultra-high field pulsed magnets. Recently, it has also been considered for reinforcement in superconducting wires used in ultra-high field superconducting magnets. For these applications, accurate measurement of its physical properties at cryogenic temperatures is very important. In this paper, physical properties including electrical resistivity, specific heat, thermal conductivity, and magnetization of as-received and aged samples are measured from 2 to 300 K. The electrical resistivity of the aged sample is slightly higher than the as-received sample, both showing a weak linear temperature dependence in the entire range of 2-300 K. The measured specific heat Cp of 430 J/kg-K at 295 K agrees with a theoretical prediction, but is significantly smaller than the values in the literature. The thermal conductivity between 2 and 300 K is in good agreement with the literature which is only available above 77 K. Magnetic property of MP35N® changes significantly with aging. The as-received sample exhibits Curie paramagnetism with a Curie constant C = 0.175 K. While the aged sample contains small amounts of a ferromagnetic phase even at room temperature. The measured MP35N® properties will be useful for the engineering design of pulsed magnets and superconducting magnets using MP35N® as reinforcement.

  13. The community Noah land surface model with multiparameterization options (Noah-MP): 1. Model description and evaluation with local-scale measurements

    KAUST Repository

    Niu, Guo-Yue

    2011-06-24

    This first paper of the two-part series describes the objectives of the community efforts in improving the Noah land surface model (LSM), documents, through mathematical formulations, the augmented conceptual realism in biophysical and hydrological processes, and introduces a framework for multiple options to parameterize selected processes (Noah-MP). The Noah-MP\\'s performance is evaluated at various local sites using high temporal frequency data sets, and results show the advantages of using multiple optional schemes to interpret the differences in modeling simulations. The second paper focuses on ensemble evaluations with long-term regional (basin) and global scale data sets. The enhanced conceptual realism includes (1) the vegetation canopy energy balance, (2) the layered snowpack, (3) frozen soil and infiltration, (4) soil moisture-groundwater interaction and related runoff production, and (5) vegetation phenology. Sample local-scale validations are conducted over the First International Satellite Land Surface Climatology Project (ISLSCP) Field Experiment (FIFE) site, the W3 catchment of Sleepers River, Vermont, and a French snow observation site. Noah-MP shows apparent improvements in reproducing surface fluxes, skin temperature over dry periods, snow water equivalent (SWE), snow depth, and runoff over Noah LSM version 3.0. Noah-MP improves the SWE simulations due to more accurate simulations of the diurnal variations of the snow skin temperature, which is critical for computing available energy for melting. Noah-MP also improves the simulation of runoff peaks and timing by introducing a more permeable frozen soil and more accurate simulation of snowmelt. We also demonstrate that Noah-MP is an effective research tool by which modeling results for a given process can be interpreted through multiple optional parameterization schemes in the same model framework. Copyright © 2011 by the American Geophysical Union.

  14. Shrimp TAB1 interacts with TAK1 and p38 and activates the host innate immune response to bacterial infection.

    Science.gov (United States)

    Wang, Sheng; Li, Mengqiao; Yin, Bin; Li, Haoyang; Xiao, Bang; Lǚ, Kai; Huang, Zhijian; Li, Sedong; He, Jianguo; Li, Chaozheng

    2017-08-01

    Mammalian TAB1 has been previously identified as transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) binding protein, which functions as the activator of TAK1 and p38. This report, for the first time, identified and characterized the homolog of TAB1 in shrimp, to be specific, the homolog gene from Litopenaeus vannamei, containing a 1560-bp open reading frame (ORF) that encoded a putative protein of 519 amino acids with the conserved PP2Cc (Serine/threonine phosphatases, family 2C, catalytic) domain in N-terminal and a TAK1 binding motif in C-terminus, has been cloned and named LvTAB1. LvTAB1 was most abundant in gills and its expression could respond significantly to a series of stimuli, including LPS, Vibrio parahemolyticus and Staphylococcus aureus. Moreover, Co-immunoprecipitation (Co-IP) experiments showed that LvTAB1 could combine with LvTAK1 as well as Lvp38, two members of IMD-NF-κB/MAPK pathway, which meant LvTAB1 could have a role in regulating the activities of these kinases. Over-expression of LvTAB1 in drosophila S2 cells could improve the transcriptional levels of antimicrobial peptide genes (AMPs) such as Diptericin (Dpt), the hallmark of drosophila NF-κB activated genes, indicating its activation effect on NF-κB pathway. Furthermore, suppression of LvTAB1 expression in vivo by RNA-interference increased the sensibility of shrimps to V. parahaemolyticus infection, implying its protective role against bacterial infection. In conclusion, these results provide some insight into the function of LvTAB1 during bacterial infection. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. A Medicago truncatula EF-hand family gene, MtCaMP1, is involved in drought and salt stress tolerance.

    Directory of Open Access Journals (Sweden)

    Tian-Zuo Wang

    Full Text Available BACKGROUND: Calcium-binding proteins that contain EF-hand motifs have been reported to play important roles in transduction of signals associated with biotic and abiotic stresses. To functionally characterize genes of EF-hand family in response to abiotic stress, an MtCaMP1 gene belonging to EF-hand family from legume model plant Medicago truncatula was isolated and its function in response to drought and salt stress was investigated by expressing MtCaMP1 in Arabidopsis. METHODOLOGY/PRINCIPAL FINDINGS: Transgenic Arabidopsis seedlings expressing MtCaMP1 exhibited higher survival rate than wild-type seedlings under drought and salt stress, suggesting that expression of MtCaMP1 confers tolerance of Arabidopsis to drought and salt stress. The transgenic plants accumulated greater amounts of Pro due to up-regulation of P5CS1 and down-regulation of ProDH than wild-type plants under drought stress. There was a less accumulation of Na(+ in the transgenic plants than in WT plants due to reduced up-regulation of AtHKT1 and enhanced regulation of AtNHX1 in the transgenic plants compared to WT plants under salt stress. There was a reduced accumulation of H2O2 and malondialdehyde in the transgenic plants than in WT plants under both drought and salt stress. CONCLUSIONS/SIGNIFICANCE: The expression of MtCaMP1 in Arabidopsis enhanced tolerance of the transgenic plants to drought and salt stress by effective osmo-regulation due to greater accumulation of Pro and by minimizing toxic Na(+ accumulation, respectively. The enhanced accumulation of Pro and reduced accumulation of Na(+ under drought and salt stress would protect plants from water default and Na(+ toxicity, and alleviate the associated oxidative stress. These findings demonstrate that MtCaMP1 encodes a stress-responsive EF-hand protein that plays a regulatory role in response of plants to drought and salt stress.

  16. Global stability of an SIR model with differential infectivity on complex networks

    Science.gov (United States)

    Yuan, Xinpeng; Wang, Fang; Xue, Yakui; Liu, Maoxing

    2018-06-01

    In this paper, an SIR model with birth and death on complex networks is analyzed, where infected individuals are divided into m groups according to their infection and contact between human is treated as a scale-free social network. We obtain the basic reproduction number R0 as well as the effects of various immunization schemes. The results indicate that the disease-free equilibrium is locally and globally asymptotically stable in some conditions, otherwise disease-free equilibrium is unstable and exists an unique endemic equilibrium that is globally asymptotically stable. Our theoretical results are confirmed by numerical simulations and a promising way for infectious diseases control is suggested.

  17. Conditional Expression of Human 15-Lipoxygenase-1 in Mouse Prostate Induces Prostatic Intraepithelial Neoplasia: The FLiMP Mouse Model

    Directory of Open Access Journals (Sweden)

    Uddhav P. Kelavkar

    2006-06-01

    Full Text Available The incidence and mortality of prostate cancer (PCa vary greatly in different geographic regions, for which lifestyle factors, such as dietary fat intake, have been implicated. Human 15-lipoxygenase-1 (h15-LO-1, which metabolizes polyunsaturated fatty acids, is a highly regulated, tissue-specific, lipid-peroxidating enzyme that functions in physiological membrane remodeling and in the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. We have shown that aberrant overexpression of 15-LO-1 occurs in human PCa, particularly high-grade PCa, and in high-grade prostatic intraepithelial neoplasia (HGPIN, and that the murine orthologue is increased in SV40-based genetically engineered mouse (GEM models of PCa, such as LADY and TRansgenic Adenocarcinoma of Mouse Prostate. To further define the role of 15-LO-1 in prostate carcinogenesis, we established a novel GEM model with targeted overexpression of h15-LO-1 in the prostate [human fifteen lipoxygenase-1 in mouse prostate (FLiMP]. We used a Cre- mediated and a loxP-mediated recombination strategy to target h15-LO-1 specifically to the prostate of C57BL/6 mice. Wild-type (wt, FLiMP+/-, and FLiMP+/+ mice aged 7 to 21, 24 to 28, and 35 weeks were characterized by histopathology, immunohistochemistry (IHC, and DNA/RNA and enzyme analyses. Compared to wt mice, h15-LO-1 enzyme activity was increased similarly in both homozygous FLiMP+/+ and hemizygous FLiMP+/- prostates. Dorsolateral and ventral prostates of FLiMP mice showed focal and progressive epithelial hyperplasia with nuclear atypia, indicative of the definition of mouse prostatic intraepithelial neoplasia (mPIN according to the National Cancer Institute. These foci showed increased proliferation by Ki-67 IHC. No progression to invasive PCa was noted up to 35 weeks. By IHC, h15-LO-1 expression was limited to luminal epithelial cells, with increased expression in mPIN foci (similar to human HGPIN. In summary, targeted overexpression of h

  18. INES: The International Nuclear Event Scale. User's manual

    International Nuclear Information System (INIS)

    1990-08-01

    The International Nuclear Event Scale (INES) is being introduced for a trial period, the primary purpose being to facilitate communication between the nuclear community, the media and the public on such events. The scale runs from zero, for events with no safety significance, to seven for a major accident. The scale has been circulated to Member States of the International Atomic Energy Agency (IAEA) and the Nuclear Energy Agency of the Organisation for Economic Co-operation and Development and it is presently anticipated that the trial period will last until late 1991. Provision has been made for the scale to be refined thereafter in the light of experience. It is designed as an important tool in providing prompt, clear and consistent information on nuclear events wherever and whenever they may occur. 2 figs, 2 tabs

  19. [Sir Arthur Conan Doyle, Sherlock Holmes and infectious diseases].

    Science.gov (United States)

    Ledermann D, Walter

    2010-10-01

    Besides a pleasant author of best sellers, Sir Arthur Conan Doyle was a medical doctor, writing excellent short stories about the exercise of his profession in England. However, even he mentions The British Medical Journal and The Lancet in the Sherlock Holmes's stories, when in the plot introduces infectious diseases, Conan Doyle ignores important discoveries in the field of tetanus. Anyway, the appearing of infectious diseases in the adventures of the detective are rare: one mention of tetanus, another of leprosy and- the most analyzed in medical literature a case of murder by inoculation of bacteria, probably the agent of melioidosis. Also he makes his hero discovers the toxic actions of a medusa and a transplant of solid organ. Little for a physician and less for an author who also wrote science fiction: it seems that the history of the great medical discoveries at the end of nineteenth century and beginning of the twentieth has passed by his side.., and he just couldn't see it.

  20. Genome sequencing and analysis of the first complete genome of Lactobacillus kunkeei strain MP2, an Apis mellifera gut isolate

    Directory of Open Access Journals (Sweden)

    Freddy Asenjo

    2016-04-01

    Full Text Available Background. The honey bee (Apis mellifera is the most important pollinator in agriculture worldwide. However, the number of honey bees has fallen significantly since 2006, becoming a huge ecological problem nowadays. The principal cause is CCD, or Colony Collapse Disorder, characterized by the seemingly spontaneous abandonment of hives by their workers. One of the characteristics of CCD in honey bees is the alteration of the bacterial communities in their gastrointestinal tract, mainly due to the decrease of Firmicutes populations, such as the Lactobacilli. At this time, the causes of these alterations remain unknown. We recently isolated a strain of Lactobacillus kunkeei (L. kunkeei strain MP2 from the gut of Chilean honey bees. L. kunkeei, is one of the most commonly isolated bacterium from the honey bee gut and is highly versatile in different ecological niches. In this study, we aimed to elucidate in detail, the L. kunkeei genetic background and perform a comparative genome analysis with other Lactobacillus species. Methods. L. kunkeei MP2 was originally isolated from the guts of Chilean A. mellifera individuals. Genome sequencing was done using Pacific Biosciences single-molecule real-time sequencing technology. De novo assembly was performed using Celera assembler. The genome was annotated using Prokka, and functional information was added using the EggNOG 3.1 database. In addition, genomic islands were predicted using IslandViewer, and pro-phage sequences using PHAST. Comparisons between L. kunkeei MP2 with other L. kunkeei, and Lactobacillus strains were done using Roary. Results. The complete genome of L. kunkeei MP2 comprises one circular chromosome of 1,614,522 nt. with a GC content of 36,9%. Pangenome analysis with 16 L. kunkeei strains, identified 113 unique genes, most of them related to phage insertions. A large and unique region of L. kunkeei MP2 genome contains several genes that encode for phage structural protein and

  1. Statistical Analysis of Solar Events Associated with SSC over Year of Solar Maximum during Cycle 23: 1. Identification of Related Sun-Earth Events

    Science.gov (United States)

    Grison, B.; Bocchialini, K.; Menvielle, M.; Chambodut, A.; Cornilleau-Wehrlin, N.; Fontaine, D.; Marchaudon, A.; Pick, M.; Pitout, F.; Schmieder, B.; Regnier, S.; Zouganelis, Y.

    2017-12-01

    Taking the 32 sudden storm commencements (SSC) listed by the observatory de l'Ebre / ISGI over the year 2002 (maximal solar activity) as a starting point, we performed a statistical analysis of the related solar sources, solar wind signatures, and terrestrial responses. For each event, we characterized and identified, as far as possible, (i) the sources on the Sun (Coronal Mass Ejections -CME-), with the help of a series of herafter detailed criteria (velocities, drag coefficient, radio waves, polarity), as well as (ii) the structure and properties in the interplanetary medium, at L1, of the event associated to the SSC: magnetic clouds -MC-, non-MC interplanetary coronal mass ejections -ICME-, co-rotating/stream interaction regions -SIR/CIR-, shocks only and unclear events that we call "miscellaneous" events. The categorization of the events at L1 is made on published catalogues. For each potential CME/L1 event association we compare the velocity observed at L1 with the one observed at the Sun and the estimated balistic velocity. Observations of radio emissions (Type II, Type IV detected from the ground and /or by WIND) associated to the CMEs make the solar source more probable. We also compare the polarity of the magnetic clouds with the hemisphere of the solar source. The drag coefficient (estimated with the drag-based model) is calculated for each potential association and it is compared to the expected range values. We identified a solar source for 26 SSC related events. 12 of these 26 associations match all criteria. We finally discuss the difficulty to perform such associations.

  2. Different strategies of osmoadaptation in the closely related marine myxobacteria Enhygromyxa salina SWB007 and Plesiocystis pacifica SIR-1.

    Science.gov (United States)

    Amiri Moghaddam, Jamshid; Boehringer, Nils; Burdziak, Amal; Kunte, Hans-Jörg; Galinski, Erwin A; Schäberle, Till F

    2016-02-03

    Only a few myxobacteria are known to date which are classified as marine due to their salt-dependency. In this study, the salt tolerance mechanism of these bacteria was investigated. Therefore, a growth medium was designed, in which the mutated Escherichia coli strain BKA13 served as sole food source for the predatory, heterotrophic myxobacteria. This enabled measurement of the osmolytes without any background and revealed that the closely related strains Enhygromyxa salina SWB007 and Plesiocystis pacifica SIR-1 developed different strategies to handle salt stress. P. pacifica SIR-1, which was grown between 1-4 % NaCl, relies solely on the accumulation of amino acids, while E. salina SWB007, which was grown between 0.5-3 % NaCl, employs, beside betaine, hydroxyectoine as the major compatible solute. In accordance with this analysis, only in the latter strain a gene locus was identified which codes for genes corresponding to the biosynthesis of betaine, ectoine, and hydroxyectoine.

  3. Novel surgical performance evaluation approximates Standardized Incidence Ratio with high accuracy at simple means.

    Science.gov (United States)

    Gabbay, Itay E; Gabbay, Uri

    2013-01-01

    Excess adverse events may be attributable to poor surgical performance but also to case-mix, which is controlled through the Standardized Incidence Ratio (SIR). SIR calculations can be complicated, resource consuming, and unfeasible in some settings. This article suggests a novel method for SIR approximation. In order to evaluate a potential SIR surrogate measure we predefined acceptance criteria. We developed a new measure - Approximate Risk Index (ARI). "Number Needed for Event" (NNE) is the theoretical number of patients needed "to produce" one adverse event. ARI is defined as the quotient of the group of patients needed for no observed events Ge by total patients treated Ga. Our evaluation compared 2500 surgical units and over 3 million heterogeneous risk surgical patients that were induced through a computerized simulation. Surgical unit's data were computed for SIR and ARI to evaluate compliance with the predefined criteria. Approximation was evaluated by correlation analysis and performance prediction capability by Receiver Operating Characteristics (ROC) analysis. ARI strongly correlates with SIR (r(2) = 0.87, p 0.9) 87% sensitivity and 91% specificity. ARI provides good approximation of SIR and excellent prediction capability. ARI is simple and cost-effective as it requires thorough risk evaluation of only the adverse events patients. ARI can provide a crucial screening and performance evaluation quality control tool. The ARI method may suit other clinical and epidemiological settings where relatively small fraction of the entire population is affected. Copyright © 2013 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

  4. Deforestation and Secondary Growth in Rondonia, Brazil from SIR-C SAR and Landsat.SPOT data

    Science.gov (United States)

    Rignot, Eric; Salas, William A.; Skole, David L.

    1996-01-01

    Covers problems with existing data collected with high-resolution optical sensors. They say active microwave sensors could complement other sensors in getting through things like cloud cover. They analyzed SIR-C data in combination with Landsat TM data, a 9-year time series of SPOT XS data, and a preliminary field survey. They report findings and draw conclusions, including that SARs operating at long radar wavelengths, with both like and cross-polarizations, are needed for tropical deforestation studies.

  5. Increased extracellular heat shock protein 90α in severe sepsis and SIRS associated with multiple organ failure and related to acute inflammatory-metabolic stress response in children.

    Science.gov (United States)

    Fitrolaki, Michaela-Diana; Dimitriou, Helen; Venihaki, Maria; Katrinaki, Marianna; Ilia, Stavroula; Briassoulis, George

    2016-08-01

    Mammalian heat-shock-protein (HSP) 90α rapidly responses to environmental insults. We examined the hypothesis that not only serum HSP72 but also HSP90α is increased in the systemic inflammatory response syndrome (SIRS), severe-sepsis (SS), and/or sepsis (S) compared to healthy children (H); we assessed HSP90α relation to (a) multiple organ system failure (MOSF) and (b) inflammatory-metabolic response and severity of illness.A total of 65 children with S, SS, or SIRS and 25 H were included. ELISA was used to evaluate extracellular HSP90α and HSP72, chemiluminescence interleukins (ILs), flow-cytometry neutrophil-CD64 (nCD64)-expression.HSP90α, along with HSP72, were dramatically increased among MOSF patients. Patients in septic groups and SIRS had elevated HSP90α compared to H (P stress, fever, outcome endpoints, and predicted mortality and inversely related to the low-LDL/low-HDL stress metabolic pattern.

  6. The Circadian Schedule for Childhood Acute Lymphoblastic Leukemia Maintenance Therapy does not Influence Event-Free Survival in the NOPHO ALL92 Protocol

    DEFF Research Database (Denmark)

    Clemmensen, Kim K. B.; Christensen, Regitse H.; Shabaneh, Diana N.

    2014-01-01

    BACKGROUND: The event-free survival of childhood acute lymphoblastic leukemia (ALL) has been reported to be superior when oral methotrexate (MTX) and 6-mercaptopurine (6MP) maintenance therapy (MT) is administered in the evening compared to the morning. PROCEDURE: In the ALL92 MT study we prospec...

  7. Experiment of X-MP CRAY multitasking with vectorial Monte Carlo algorithm

    International Nuclear Information System (INIS)

    Chauvet, Y.

    1984-08-01

    After a short comparison between CRAY-1S and CRAY X-MP we present the main multitasking tools available with FORTRAN. Next we present the main characteristics of the algorithm used and the principles of its parallelization. At last we show the measured results on the two computers and we prove that tasks should be long enough to get a good speed-up factor [fr

  8. The PDE10A inhibitor MP-10 and haloperidol produce distinct gene expression profiles in the striatum and influence cataleptic behavior in rodents.

    Science.gov (United States)

    Gentzel, Renee C; Toolan, Dawn; Roberts, Rhonda; Koser, Amy Jo; Kandebo, Monika; Hershey, James; Renger, John J; Uslaner, Jason; Smith, Sean M

    2015-12-01

    Phosphodiesterase 10A (PDE10A) has garnered attention as a potential therapeutic target for schizophrenia due to its prominent striatal expression and ability to modulate striatal signaling. The present study used the selective PDE10A inhibitor MP-10 and the dopamine D2 antagonist haloperidol to compare effects of PDE10A inhibition and dopamine D2 blockade on striatopallidal (D2) and striatonigral (D1) pathway activation. Our studies confirmed that administration of MP-10 significantly elevates expression of the immediate early genes (IEG) c-fos, egr-1, and arc in rat striatum. Furthermore, we demonstrated that MP-10 induced egr-1 expression was distributed evenly between enkephalin-containing D2-neurons and substance P-containing D1-neurons. In contrast, haloperidol (3 mg/kg) selectively activated egr-1 expression in enkephalin neurons. Co-administration of MP-10 and haloperidol (0.5 mg/kg) increased IEG expression to a greater extent than either compound alone. Similarly, in a rat catalepsy assay, administration of haloperidol (0.5 mg/kg) or MP-10 (3-30 mg/kg) did not produce cataleptic behavior when dosed alone, but co-administration of haloperidol with MP-10 (3 and 10 mg/kg) induced cataleptic behaviors. Interestingly, co-administration of haloperidol with a high dose of MP-10 (30 mg/kg) failed to produce cataleptic behavior. These findings are important for understanding the neural circuits involved in catalepsy and suggest that the behavioral effects produced by PDE10A inhibitors may be influenced by concomitant medication and the level of PDE10A inhibition achieved by the dose of the inhibitor. Copyright © 2015. Published by Elsevier Ltd.

  9. Sir Francis Joseph Campbell and His Family: The First Family in Professional Services for People Who Are Blind or Visually Impaired

    Science.gov (United States)

    Welsh, Richard L.

    2008-01-01

    The author discusses the pivotal roles of Sir Francis Campbell (1832-1914) and members of his family, especially his son Charles Campbell, in the evolution of the blindness field to a professional and reason-based service.

  10. MythBusters, Musicians, and MP3 Players: A Middle School Sound Study

    Science.gov (United States)

    Putney, Ann

    2011-01-01

    Create your own speakers for an MP3 player while exploring the science of sound. Review of science notebooks, students' intriguing cabinet designs, and listening to students talk with a musician about the physics of an instrument show that complex concepts are being absorbed and extended with each new iteration. Science that matters to students…

  11. Performance Comparison of OpenMP, MPI, and MapReduce in Practical Problems

    Directory of Open Access Journals (Sweden)

    Sol Ji Kang

    2015-01-01

    Full Text Available With problem size and complexity increasing, several parallel and distributed programming models and frameworks have been developed to efficiently handle such problems. This paper briefly reviews the parallel computing models and describes three widely recognized parallel programming frameworks: OpenMP, MPI, and MapReduce. OpenMP is the de facto standard for parallel programming on shared memory systems. MPI is the de facto industry standard for distributed memory systems. MapReduce framework has become the de facto standard for large scale data-intensive applications. Qualitative pros and cons of each framework are known, but quantitative performance indexes help get a good picture of which framework to use for the applications. As benchmark problems to compare those frameworks, two problems are chosen: all-pairs-shortest-path problem and data join problem. This paper presents the parallel programs for the problems implemented on the three frameworks, respectively. It shows the experiment results on a cluster of computers. It also discusses which is the right tool for the jobs by analyzing the characteristics and performance of the paradigms.

  12. Assessment of skeletal age using MP3 and hand-wrist radiographs and its correlation with dental and chronological ages in children.

    Science.gov (United States)

    Bala, M; Pathak, A; Jain, R L

    2010-01-01

    The purpose of the study was to assess skeletal age using MP3 and hand-wrist radiographs and to find the correlation amongst the skeletal, dental and chronological ages. One hundred and sixty North-Indian healthy children in the age group 8-14 years, comprising equal number of males and females were included in the study. The children were radiographed for middle phalanx of third finger (MP3) and hand-wrist of the right hand and intra oral periapical X-ray for right permanent maxillary canine. Skeletal age was assessed from MP3 and hand-wrist radiographs according to the standards of Greulich and Pyle. The dental age was assessed from IOPA radiographs of right permanent maxillary canine based on Nolla's calcification stages. Skeletal age from MP3 and hand-wrist radiographs shows high correlation in all the age groups for both sexes. Females were advanced in skeletal maturation than males. Skeletal age showed high correlation with dental age in 12-14 years age group. Chronological age showed inconsistent correlation with dental and skeletal ages.

  13. NASA: A generic infrastructure for system-level MP-SoC design space exploration

    NARCIS (Netherlands)

    Jia, Z.J.; Pimentel, A.D.; Thompson, M.; Bautista, T.; Núñez, A.

    2010-01-01

    System-level simulation and design space exploration (DSE) are key ingredients for the design of multiprocessor system-on-chip (MP-SoC) based embedded systems. The efforts in this area, however, typically use ad-hoc software infrastructures to facilitate and support the system-level DSE experiments.

  14. Ut Pictura Poesis : dialéctica entre palabras e imagen en Sir William Sterling Maxwell

    Directory of Open Access Journals (Sweden)

    Hilary Macartney

    2002-01-01

    Full Text Available En el presente artículo se analiza la estrecha relación entre la historia del arte de Sir William Stirling Maxwell, su biblioteca y su colección artística. Este vínculo encierra la clave para la comprensión de su excepcional aportación a la historiografía del arte español. Sus diversas actividades, como historiador del arte, coleccionista de libros y cuadros, y director de ediciones privadas de libros raros, fueron todas manifestaciones de su gran fascinación por el paralelo entre la literatura y el arte, la palabra y la imagen. Tal relación se encuentra incluso en el esquema decorativo de su biblioteca.This article examines the remarkable unity between Sir William Stirling Maxwell's art history, his library and his art collection and argües that this relationship is the key to understanding his unique contribution to scholarship of Spanish art. In particular, it will be shown that his actlvities as an art historian, bibliophile, art collector and editor of prívate editions of rare books were all expressions of his fascination with the relationship between literature and art in general, and more specifically between word and image. Even the decorative scheme of his library emphasised this relationship.

  15. A mixed SIR-SIS model to contain a virus spreading through networks with two degrees

    Science.gov (United States)

    Essouifi, Mohamed; Achahbar, Abdelfattah

    Due to the fact that the “nodes” and “links” of real networks are heterogeneous, to model computer viruses prevalence throughout the Internet, we borrow the idea of the reduced scale free network which was introduced recently. The purpose of this paper is to extend the previous deterministic two subchains of Susceptible-Infected-Susceptible (SIS) model into a mixed Susceptible-Infected-Recovered and Susceptible-Infected-Susceptible (SIR-SIS) model to contain the computer virus spreading over networks with two degrees. Moreover, we develop its stochastic counterpart. Due to the high protection and security taken for hubs class, we suggest to treat it by using SIR epidemic model rather than the SIS one. The analytical study reveals that the proposed model admits a stable viral equilibrium. Thus, it is shown numerically that the mean dynamic behavior of the stochastic model is in agreement with the deterministic one. Unlike the infection densities i2 and i which both tend to a viral equilibrium for both approaches as in the previous study, i1 tends to the virus-free equilibrium. Furthermore, since a proportion of infectives are recovered, the global infection density i is minimized. Therefore, the permanent presence of viruses in the network due to the lower-degree nodes class. Many suggestions are put forward for containing viruses propagation and minimizing their damages.

  16. Restoration of mp53 to wtp53 by chemical chaperones restores p53-dependent apoptosis after radiotherapy

    International Nuclear Information System (INIS)

    Ohnishi, T.; Asakawa, I.; Tamamoto, T.; Takahashi, A.; Ohnishi, K.

    2003-01-01

    The mutations of many kinds of cancer related genes have been investigated for the predictive assay against cancer therapy by the application of molecular biology. A tumor suppressor gene product of wtp53 plays important roles in cancer suppression through the induction of cell growth arrest, DNA repair or apoptosis. The p53 exerts its function by induction of downstream genes and/or interaction to various proteins. Mutations in the p53 gene (mp53) cause conformational alterations in the p53 protein, the majority of which can no longer induce expression of the downstream genes. The genetic status of p53 gene has been focused as the most important candidate among them for cancer therapy. The gene therapy of p53 has been already applied. We reported that the transfection of mp53 gene increased the radio-, thermo- and chemo-resistance, and depressed apoptosis introduced with them through bax-induction and proteolysis of PARP and caspase-3. From these results, we propose that the gene therapy of wtp53 to p53-deleted cancer cells may be very useful for cancer therapy by the combination with radiotherapy. Even in the case of mp53 cancer cells, we succeeded the restoration of mp53 to wtp53 by glycerol or C-terminal peptide of p53 as chemical chaperones. These experimental progresses might support effective cancer therapy against individual patients bearing with different p53 gene status by the use of the most suitable treatment to them in the near future

  17. Steganography on multiple MP3 files using spread spectrum and Shamir's secret sharing

    Science.gov (United States)

    Yoeseph, N. M.; Purnomo, F. A.; Riasti, B. K.; Safiie, M. A.; Hidayat, T. N.

    2016-11-01

    The purpose of steganography is how to hide data into another media. In order to increase security of data, steganography technique is often combined with cryptography. The weakness of this combination technique is the data was centralized. Therefore, a steganography technique is develop by using combination of spread spectrum and secret sharing technique. In steganography with secret sharing, shares of data is created and hidden in several medium. Medium used to concealed shares were MP3 files. Hiding technique used was Spread Spectrum. Secret sharing scheme used was Shamir's Secret Sharing. The result showed that steganography with spread spectrum combined with Shamir's Secret Share using MP3 files as medium produce a technique that could hid data into several cover. To extract and reconstruct the data hidden in stego object, it is needed the amount of stego object which more or equal to its threshold. Furthermore, stego objects were imperceptible and robust.

  18. MP Finance Group CC (In Liquidation) V C: SARS: Adding to the ...

    African Journals Online (AJOL)

    This article analyses the interpretation of the phrase “received by, accrued to or in favour of” in the gross income definition of the Income Tax Act, as applied to illegal receipts. During the last few decades, South Africans have been victims of a number of Ponzi-type schemes. In MP Finance, the Supreme Court of Appeal ...

  19. Measurement of $H{\\to}W^\\pm W^{\\mp\\ast}{\\to}\\ell^-\\bar{\

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00423318; Köneke, Karsten

    This thesis presents and discusses measurements of the coupling of the Higgs boson to vector bosons, using data collected at $\\sqrt{s}=13$ TeV by the ATLAS detector. A full analysis of the first $5.8$ fb${}^{-1}$ of LHC Run 2 data investigating the $H{\\to}W^\\pm W^{\\mp\\ast}{\\to}\\ell^-\\bar{\

  20. Filtering authentic sepsis arising in the ICU using administrative codes coupled to a SIRS screening protocol.

    Science.gov (United States)

    Sudduth, Christopher L; Overton, Elizabeth C; Lyu, Peter F; Rimawi, Ramzy H; Buchman, Timothy G

    2017-06-01

    Using administrative codes and minimal physiologic and laboratory data, we sought a high-specificity identification strategy for patients whose sepsis initially appeared during their ICU stay. We studied all patients discharged from an academic hospital between September 1, 2013 and October 31, 2014. Administrative codes and minimal physiologic and laboratory criteria were used to identify patients at high risk of developing the onset of sepsis in the ICU. Two clinicians then independently reviewed the patient record to verify that the screened-in patients appeared to become septic during their ICU admission. Clinical chart review verified sepsis in 437/466 ICU stays (93.8%). Of these 437 encounters, only 151 (34.6%) were admitted to the ICU with neither SIRS nor evidence of infection and therefore appeared to become septic during their ICU stay. Selected administrative codes coupled to SIRS criteria and applied to patients admitted to ICU can yield up to 94% authentic sepsis patients. However, only 1/3 of patients thus identified appeared to become septic during their ICU stay. Studies that depend on high-intensity monitoring for description of the time course of sepsis require clinician review and verification that sepsis initially appeared during the monitoring period. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Threshold Dynamics in Stochastic SIRS Epidemic Models with Nonlinear Incidence and Vaccination

    Directory of Open Access Journals (Sweden)

    Lei Wang

    2017-01-01

    Full Text Available In this paper, the dynamical behaviors for a stochastic SIRS epidemic model with nonlinear incidence and vaccination are investigated. In the models, the disease transmission coefficient and the removal rates are all affected by noise. Some new basic properties of the models are found. Applying these properties, we establish a series of new threshold conditions on the stochastically exponential extinction, stochastic persistence, and permanence in the mean of the disease with probability one for the models. Furthermore, we obtain a sufficient condition on the existence of unique stationary distribution for the model. Finally, a series of numerical examples are introduced to illustrate our main theoretical results and some conjectures are further proposed.

  2. Improved Reaction and Activation Energies of [4+2] Cycloadditions, [3+3] Sigmatropic Rearrangements and Electrocyclizations with the Spin-Component-Scaled MP2 Method

    NARCIS (Netherlands)

    Goumans, T.P.M.; Ehlers, A.W.; Lammertsma, K.; Wuerthwein, E.-U.; Grimme, S.

    2004-01-01

    A new quantum mechanical scheme to calculate electronic correlation energies, spin-component-scaled MP2, was tested as a tool to predict reaction energies and barriers in computational organic chemistry. Three common pericyclic reactions with known unsatisfactory MP2 descriptions were reinvestigated

  3. A time-dependent event tree technique for modelling recovery operations

    International Nuclear Information System (INIS)

    Kohut, P.; Fitzpatrick, R.

    1991-01-01

    The development of a simplified time dependent event tree methodology is presented. The technique is especially applicable to describe recovery operations in nuclear reactor accident scenarios initiated by support system failures. The event tree logic is constructed using time dependent top events combined with a damage function that contains information about the final state time behavior of the reactor core. Both the failure and the success states may be utilized for the analysis. The method is illustrated by modeling the loss of service water function with special emphasis on the RCP [reactor coolant pump] seal LOCA [loss of coolant accident] scenario. 5 refs., 2 figs., 2 tabs

  4. On pulse vaccine strategy in a periodic stochastic SIR epidemic model

    International Nuclear Information System (INIS)

    Wang, Fengyan; Wang, Xiaoyi; Zhang, Shuwen; Ding, Changming

    2014-01-01

    A periodic stochastic SIR epidemic model with pulse vaccination is studied. The system has global positive solutions and under some conditions it admits a unique positive periodic disease-free solution, which is globally exponentially stable in mean square. The mathematical expectation and variance of the positive periodic solution are obtained. Two threshold parameters R 1 and R 2 (R 1 >R 2 ) are identified; if R 1 <1, the susceptible will be persistent in the mean and the disease will go to extinction; if R 2 >1, the susceptible and the disease will be weakly persistent in the mean. We show that by repeatedly vaccinating the susceptible population in series of pulses, it is possible to eradicate the infective from the entire model population in the random environment

  5. Granular statistical mechanics - Building on the legacy of Sir Sam Edwards

    Science.gov (United States)

    Blumenfeld, Raphael

    When Sir Sam Edwards laid down the foundations for the statistical mechanics of jammed granular materials he opened a new field in soft condensed matter and many followed. In this presentation we review briefly the Edwards formalism and some of its less discussed consequences. We point out that the formalism is useful for other classes of systems - cellular and porous materials. A certain shortcoming of the original formalism is then discussed and a modification to overcome it is proposed. Finally, a derivation of an equation of state with the new formalism is presented; the equation of state is analogous to the PVT relation for thermal gases, relating the volume, the boundary stress and measures of the structural and stress fluctuations. NUDT, Changsha, China, Imperial College London, UK, Cambridge University, UK.

  6. The benefits of Outsourcing facility services when selecting right service provider for a hotel:Case Kämp Group Oy

    OpenAIRE

    Paudyal, Manoj; Acharya, Saroj

    2015-01-01

    This research paper examines about the outsourcing of facility services in the Kämp group of hotels. The scope of the study includes Facility Management, outsourcing facilities services, and the selection process of the service providers for a hotel. The research was carried at the hotels of Kämp group Oy in the Metropolitan Area of Helsinki. Facility management includes wide ranges of non-core functions such as Property management, real estates, design and technology. Activities such as secu...

  7. Development of Immunopathobiogenesis on SIRS-Sepsis

    Directory of Open Access Journals (Sweden)

    A Guntur Hermawan

    2009-04-01

    Full Text Available Over the past decade, sepsis has been diagnosed according to consensus guidelines established in 1991 as an infection in addition to the symptoms of systemic inflammatory response syndrome (SIRS. In addition to the previous criteria, the 2001 conference added several new diagnostic criteria for sepsis. Of particular interest was the inclusion of the biomarkers procalcitonin (PCT and C-reactive protein (CRP, despite the overall conclusion that it was premature to use biomarkers for sepsis diagnosis. The primary recommendation of the panel was the implementation of the Predisposition, insult Infection, Response, and Organ dysfunction (PIRO.The immune system has traditionally been devided into innate and adaptive components, each of which has a different role and function in defending the host against infectious agents. Stimulation of different TLRs induces distinct patterns of gene expression, which not only leads to the activation of innate immunity but also increasing evidence supports an additional critical role for TLRs in orchestrating the development of adaptive immune responses. The superantigens are able to induce toxic shock syndrome and can sometimes cause multiple organ failure via adaptive immune system. The superantigenic activity of the bacterial exotoxins can be attributed to their ability to cross-link major histocompatibility complex class II molecules on antigen-presenting cells outside the peptide groove with T-cell receptors to form a trimolecular complex. This trimolecular interaction leads to uncontrolled release of a number of proinflammatory cytokines. Proinflammatory cytokines especially IFN-γ and TNF-α, the key cytokines causing toxic shock syndrome. KEYWORDS: sepsis, innate immunity, adaptive.

  8. EVALUASI PENGELOLAAN MP-ASI LOKAL DAN PENGARUHNYA TERHADAP PENINGKATAN BERAT BADAN DAN STATUS GIZI BALITA USIA 6-24 BULAN DI PUSKESMAS PURWOKERTO SELATAN KABUPATEN BANYUMAS

    Directory of Open Access Journals (Sweden)

    Endo Dardjito

    2012-11-01

    Full Text Available The Evaluation of Management MP-ASI Local and The Influence Towards Body Heavy Enchanced and Children Under Five Nutrient Status Age 6-24 Months In Banyumas Regency.Background: Nutrient problem besides problem sindroma tight poverty with also concern behaviour change problem less support in alive pattern wells. In baby and child, nutrient deficit will evoke growth disturbance and development when not be overcome according to early continue up to adult. MP-ASI that given should made from cheap food stuff and easy goat local region. The wacthfullness aims to detect about management MP-ASI local and the influence toward age child body heavy enchanced 6 - 24 months.Objectives: This study aims to evaluate the local MP-ASI management and effect on growth of children aged 6 to 24 months in the Health Center of South Purwokerto, Banyumas.Methods: Study design is cohort retrospective. Total samples are 35 children under two years old (6-24 months at Community Health Centre South Purwokerto. Samples has get local supplementary feeding (MP-ASI in 2007. Data collected was socio economic household, weight of children and supplementary feeding management by interview with mother and report from Community Health Centre. Data analysis is descriptive. Nutritional status is base on Z score WHO-NCHS.Results: The local supplementary feeding (MP-ASI local that given disagrees with guides from Health Department. A large of samples (42.9% has given raw food stuff, 11.4% has give money and others 45.7%. There influence used MP-ASI local with body heavy enchanced especially 1 in 2 and 3 and the gift influence MP ASI local towards nutrient status enchanced especially in to 3, although low the connection with value p 0.032 and association value 0.289.Conclusions: Alternative nutrient problem in family necessary with approach multisector among others well being sector, industrial, agricultures and others. Necessary family enableness movement existence so that can increase

  9. Effects of Groundwater Dynamics on Hydrometeorological Conditions over South America: Analysis of Offline NoahMP and Fully-coupled WRF-NoahMP Simulations

    Science.gov (United States)

    Martinez-Agudelo, J. A.; Dominguez, F.; Miguez-Macho, G.

    2014-12-01

    Renalysis data suggests that nearly 20% of the atmospheric moisture over the La Plata basin comes from Amazonian Evapotranspiration (ET). However, these estimates of ET are model dependent. Simulations using land-surface models (LSMs) in off-line mode (i.e. with prescribed atmospheric forcing) have shown that Amazonian ET depends on the groundwater dynamics. In this study we use the NoahMP LSM in off-line mode and the coupled system WRF-NoahMP to assess the role of groundwater on South American ET. In particular, we study the role of the groundwater in sustaining ET during the dry season in the southern Amazon and the La Plata basin. We compare simulations that do not account for the groundwater reservoir (free drainage approach) with simulations that include the Miguez-Macho and Fan parameterization to represent the groundwater storage, its lateral flow, and its interaction with the unsaturated zone. The off-line simulations show the effects associated solely with groundwater dynamics (as opposed to coupled land-atmosphere processes), while the coupled simulations provide information about the regulation and/or response from the atmosphere. Preliminary results from the coupled system suggest that the largest effects of the groundwater on ET are observed during the austral dry season. ET is larger over regions of Bolivia, Paraguay and Argentina when groundwater is included, due to the existence of a relatively shallow water table over these regions, which via upward capillary fluxes reduces drainage during the rainy season and increases soil moisture availability in the dry season. These differences in the simulated ET could have an impact on the estimates of the transport of atmospheric moisture to La Plata basin.

  10. Prediction study of structural, elastic and electronic properties of FeMP (M = Ti, Zr, Hf) compounds

    Science.gov (United States)

    Tanto, A.; Chihi, T.; Ghebouli, M. A.; Reffas, M.; Fatmi, M.; Ghebouli, B.

    2018-06-01

    First principles calculations are applied in the study of FeMP (M = Ti, Zr, Hf) compounds. We investigate the structural, elastic, mechanical and electronic properties by combining first-principles calculations with the CASTEP approach. For ideal polycrystalline FeMP (M = Ti, Zr, Hf) the shear modulus, Young's modulus, Poisson's ratio, elastic anisotropy indexes, Pugh's criterion, elastic wave velocities and Debye temperature are also calculated from the single crystal elastic constants. The shear anisotropic factors and anisotropy are obtained from the single crystal elastic constants. The Debye temperature is calculated from the average elastic wave velocity obtained from shear and bulk modulus as well as the integration of elastic wave velocities in different directions of the single crystal.

  11. Accurate Open-Shell Noncovalent Interaction Energies from the Orbital-Optimized Møller-Plesset Perturbation Theory: Achieving CCSD Quality at the MP2 Level by Orbital Optimization.

    Science.gov (United States)

    Soydaş, Emine; Bozkaya, Uğur

    2013-11-12

    The accurate description of noncovalent interactions is one of the most challenging problems in modern computational chemistry, especially those for open-shell systems. In this study, an investigation of open-shell noncovalent interactions with the orbital-optimized MP2 and MP3 (OMP2 and OMP3) is presented. For the considered test set of 23 complexes, mean absolute errors in noncovalent interaction energies (with respect to CCSD(T) at complete basis set limits) are 0.68 (MP2), 0.37 (OMP2), 0.59 (MP3), 0.23 (OMP3), and 0.38 (CCSD) kcal mol(-1) . Hence, with a greatly reduced computational cost, one may achieve CCSD quality at the MP2 level by orbital optimization [scaling formally as O(N(6)) for CCSD compared to O(N(5)) for OMP2, where N is the number of basis functions]. Further, one may obtain a considerably better performance than CCSD using the OMP3 method, which has also a lower cost than CCSD.

  12. Photographic Standards for Patients With Facial Palsy and Recommendations by Members of the Sir Charles Bell Society.

    Science.gov (United States)

    Santosa, Katherine B; Fattah, Adel; Gavilán, Javier; Hadlock, Tessa A; Snyder-Warwick, Alison K

    2017-07-01

    There is no widely accepted assessment tool or common language used by clinicians caring for patients with facial palsy, making exchange of information challenging. Standardized photography may represent such a language and is imperative for precise exchange of information and comparison of outcomes in this special patient population. To review the literature to evaluate the use of facial photography in the management of patients with facial palsy and to examine the use of photography in documenting facial nerve function among members of the Sir Charles Bell Society-a group of medical professionals dedicated to care of patients with facial palsy. A literature search was performed to review photographic standards in patients with facial palsy. In addition, a cross-sectional survey of members of the Sir Charles Bell Society was conducted to examine use of medical photography in documenting facial nerve function. The literature search and analysis was performed in August and September 2015, and the survey was conducted in August and September 2013. The literature review searched EMBASE, CINAHL, and MEDLINE databases from inception of each database through September 2015. Additional studies were identified by scanning references from relevant studies. Only English-language articles were eligible for inclusion. Articles that discussed patients with facial palsy and outlined photographic guidelines for this patient population were included in the study. The survey was disseminated to the Sir Charles Bell Society members in electronic form. It consisted of 10 questions related to facial grading scales, patient-reported outcome measures, other psychological assessment tools, and photographic and videographic recordings. In total, 393 articles were identified in the literature search, 7 of which fit the inclusion criteria. Six of the 7 articles discussed or proposed views specific to patients with facial palsy. However, none of the articles specifically focused on

  13. The molecular gradient using the divide-expand-consolidate resolution of the identity second-order Møller-Plesset perturbation theory: The DEC-RI-MP2 gradient

    Energy Technology Data Exchange (ETDEWEB)

    Bykov, Dmytro; Kristensen, Kasper; Kjærgaard, Thomas [Department of Chemistry, qLeap Center for Theoretical Chemistry, University of Aarhus, DK-8000 Århus C (Denmark)

    2016-07-14

    We report an implementation of the molecular gradient using the divide-expand-consolidate resolution of the identity second-order Møller-Plesset perturbation theory (DEC-RI-MP2). The new DEC-RI-MP2 gradient method combines the precision control as well as the linear-scaling and massively parallel features of the DEC scheme with efficient evaluations of the gradient contributions using the RI approximation. We further demonstrate that the DEC-RI-MP2 gradient method is capable of calculating molecular gradients for very large molecular systems. A test set of supramolecular complexes containing up to 158 atoms and 1960 contracted basis functions has been employed to demonstrate the general applicability of the DEC-RI-MP2 method and to analyze the errors of the DEC approximation. Moreover, the test set contains molecules of complicated electronic structures and is thus deliberately chosen to stress test the DEC-RI-MP2 gradient implementation. Additionally, as a showcase example the full molecular gradient for insulin (787 atoms and 7604 contracted basis functions) has been evaluated.

  14. The molecular gradient using the divide-expand-consolidate resolution of the identity second-order Møller-Plesset perturbation theory: The DEC-RI-MP2 gradient

    International Nuclear Information System (INIS)

    Bykov, Dmytro; Kristensen, Kasper; Kjærgaard, Thomas

    2016-01-01

    We report an implementation of the molecular gradient using the divide-expand-consolidate resolution of the identity second-order Møller-Plesset perturbation theory (DEC-RI-MP2). The new DEC-RI-MP2 gradient method combines the precision control as well as the linear-scaling and massively parallel features of the DEC scheme with efficient evaluations of the gradient contributions using the RI approximation. We further demonstrate that the DEC-RI-MP2 gradient method is capable of calculating molecular gradients for very large molecular systems. A test set of supramolecular complexes containing up to 158 atoms and 1960 contracted basis functions has been employed to demonstrate the general applicability of the DEC-RI-MP2 method and to analyze the errors of the DEC approximation. Moreover, the test set contains molecules of complicated electronic structures and is thus deliberately chosen to stress test the DEC-RI-MP2 gradient implementation. Additionally, as a showcase example the full molecular gradient for insulin (787 atoms and 7604 contracted basis functions) has been evaluated.

  15. Emodin extends lifespan of Caenorhabditis elegans through insulin/IGF-1 signaling pathway depending on DAF-16 and SIR-2.1.

    Science.gov (United States)

    Zhao, Xuan; Lu, Lulu; Qi, Yonghao; Li, Miao; Zhou, Lijun

    2017-10-01

    The naturally occurring anthraquinone emodin has been serving primarily as an anti-bacterial and anti-inflammatory agent. However, little is known about its potential on anti-aging. This investigation examined the effect of emodin on lifespan and focused on its physiological molecular mechanisms in vivo. Using Caenorhabditis elegans (C. elegans) as an animal model, we found emodin could extend lifespan of worms and improve their antioxidant capacity. Our mechanistic studies revealed that emodin might function via insulin/IGF-1 signaling (IIS) pathway involving, specifically the core transcription factor DAF-16. Quantitative RT-PCR results illustrated that emodin up-regulated transcription of DAF-16 target genes which express antioxidants to promote antioxidant capacity and lifespan of worms. In addition, attenuated effect in sir-2.1 mutants suggests that emodin likely functioned in a SIR-2.1-dependent manner. Our study uncovers a novel role of emodin in prolonging lifespan and supports the understanding of emodin being a beneficial dietary supplement.

  16. X-ray, MP2 and DFT studies of the structure and vibrational spectra of trigonellinium chloride

    International Nuclear Information System (INIS)

    Szafran, M.; Koput, J.; Dega-Szafran, Z.; Katrusiak, A.; Pankowski, M.; Stobiecka, K.

    2003-01-01

    The effects of hydrogen bonding, inter- and intramolecular electrostatic interactions on the conformation of trigonellinium chloride, TRGH...Cl, in the crystal and on that of a single molecule have been studied by X-ray diffraction, FT-IR, Raman, 1 H and 13 C NMR spectroscopies, and by MP2 and DFT calculations. In the crystal, the Cl - anion is connected with protonated trigonelline via hydrogen bond, O-H...Cl - =2.915(3) Angst, and three N + ...Cl - intermolecular electrostatic interactions. In a single molecule, the Cl - anion is also engaged in a slightly longer hydrogen bond, O-H...Cl - =2.948-3.019 Angst, but only in one type of intramolecular electrostatic interaction. The optimized bond lengths and bond angles at the MP2 and B3LYP levels of theory are in good agreement with the X-ray data, except conformation of the COOH group, which is cis (syn) in the crystal and trans (anti) in the single molecule. The probable assignments for the experimental solid state vibrational spectra of TRGH.Cl and TRGD.Cl based on the calculated MP2/cc-pVDZ frequencies and intensities were made. The effect of quaternization of nicotinic acid, its salt and amide on chemical shifts of the ring protons and carbons is analyzed

  17. A Novel Wheat C-bZIP Gene, TabZIP14-B, Participates in Salt and Freezing Tolerance in Transgenic Plants

    Directory of Open Access Journals (Sweden)

    Lina Zhang

    2017-05-01

    Full Text Available The group C-bZIP transcription factors (TFs are involved in diverse biological processes, such as the regulation of seed storage protein (SSP production and the responses to pathogen challenge and abiotic stress. However, our knowledge of the abiotic functions of group C-bZIP genes in wheat remains limited. Here, we present the function of a novel TabZIP14-B gene in wheat. This gene belongs to the group C-bZIP TFs and contains six exons and five introns; three haplotypes were identified among accessions of tetraploid and hexaploid wheat. A subcellular localization analysis indicated that TabZIP14-B was targeted to the nucleus of tobacco epidermal cells. A transactivation assay demonstrated that TabZIP14-B showed transcriptional activation ability and was capable of binding the abscisic acid (ABA responsive element (ABRE in yeast. RT-qPCR revealed that TabZIP14-B was expressed in the roots, stems, leaves, and young spikes and was up-regulated by exogenous ABA, salt, low-temperature, and polyethylene glycol (PEG stress treatments. Furthermore, Arabidopsis plants overexpressing TabZIP14-B exhibited enhanced tolerance to salt, freezing stresses and ABA sensitivity. Overexpression of TabZIP14-B resulted in increased expression of the AtRD29A, AtCOR47, AtRD20, AtGSTF6, and AtRAB18 genes and changes in several physiological characteristics. These results suggest that TabZIP14-B could function as a positive regulator in mediating the abiotic stress response.

  18. Spontaneous Transient Lateral Thoracic Lung Herniation Resulting in Systemic Inflammatory Response Syndrome (SIRS and Subsequent Contralateral Lung Injury

    Directory of Open Access Journals (Sweden)

    Antony Kaliyadan

    2011-01-01

    Full Text Available Lung herniation is a relatively rare clinical entity that is most commonly either congenital or acquired traumatically. We describe a case of spontaneous lung herniation secondary to acute cough in an obese male smoker complicated by contralateral acute lung injury and systemic inflammatory response syndrome (SIRS. Mechanisms of lung herniation, classification, diagnosis, and management will be discussed.

  19. MpTheory Java library: a multi-platform Java library for systems biology based on the Metabolic P theory.

    Science.gov (United States)

    Marchetti, Luca; Manca, Vincenzo

    2015-04-15

    MpTheory Java library is an open-source project collecting a set of objects and algorithms for modeling observed dynamics by means of the Metabolic P (MP) theory, that is, a mathematical theory introduced in 2004 for modeling biological dynamics. By means of the library, it is possible to model biological systems both at continuous and at discrete time. Moreover, the library comprises a set of regression algorithms for inferring MP models starting from time series of observations. To enhance the modeling experience, beside a pure Java usage, the library can be directly used within the most popular computing environments, such as MATLAB, GNU Octave, Mathematica and R. The library is open-source and licensed under the GNU Lesser General Public License (LGPL) Version 3.0. Source code, binaries and complete documentation are available at http://mptheory.scienze.univr.it. luca.marchetti@univr.it, marchetti@cosbi.eu Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  20. Innovative Language-Based & Object-Oriented Structured AMR Using Fortran 90 and OpenMP

    Science.gov (United States)

    Norton, C.; Balsara, D.

    1999-01-01

    Parallel adaptive mesh refinement (AMR) is an important numerical technique that leads to the efficient solution of many physical and engineering problems. In this paper, we describe how AMR programing can be performed in an object-oreinted way using the modern aspects of Fortran 90 combined with the parallelization features of OpenMP.

  1. Hybrid MPI/OpenMP parallelization of the explicit Volterra integral equation solver for multi-core computer architectures

    KAUST Repository

    Al Jarro, Ahmed

    2011-08-01

    A hybrid MPI/OpenMP scheme for efficiently parallelizing the explicit marching-on-in-time (MOT)-based solution of the time-domain volume (Volterra) integral equation (TD-VIE) is presented. The proposed scheme equally distributes tested field values and operations pertinent to the computation of tested fields among the nodes using the MPI standard; while the source field values are stored in all nodes. Within each node, OpenMP standard is used to further accelerate the computation of the tested fields. Numerical results demonstrate that the proposed parallelization scheme scales well for problems involving three million or more spatial discretization elements. © 2011 IEEE.

  2. Assessment of the Weather Research and Forecasting (WRF) model for simulation of extreme rainfall events in the upper Ganga Basin

    Science.gov (United States)

    Chawla, Ila; Osuri, Krishna K.; Mujumdar, Pradeep P.; Niyogi, Dev

    2018-02-01

    Reliable estimates of extreme rainfall events are necessary for an accurate prediction of floods. Most of the global rainfall products are available at a coarse resolution, rendering them less desirable for extreme rainfall analysis. Therefore, regional mesoscale models such as the advanced research version of the Weather Research and Forecasting (WRF) model are often used to provide rainfall estimates at fine grid spacing. Modelling heavy rainfall events is an enduring challenge, as such events depend on multi-scale interactions, and the model configurations such as grid spacing, physical parameterization and initialization. With this background, the WRF model is implemented in this study to investigate the impact of different processes on extreme rainfall simulation, by considering a representative event that occurred during 15-18 June 2013 over the Ganga Basin in India, which is located at the foothills of the Himalayas. This event is simulated with ensembles involving four different microphysics (MP), two cumulus (CU) parameterizations, two planetary boundary layers (PBLs) and two land surface physics options, as well as different resolutions (grid spacing) within the WRF model. The simulated rainfall is evaluated against the observations from 18 rain gauges and the Tropical Rainfall Measuring Mission Multi-Satellite Precipitation Analysis (TMPA) 3B42RT version 7 data. From the analysis, it should be noted that the choice of MP scheme influences the spatial pattern of rainfall, while the choice of PBL and CU parameterizations influences the magnitude of rainfall in the model simulations. Further, the WRF run with Goddard MP, Mellor-Yamada-Janjic PBL and Betts-Miller-Janjic CU scheme is found to perform best in simulating this heavy rain event. The selected configuration is evaluated for several heavy to extremely heavy rainfall events that occurred across different months of the monsoon season in the region. The model performance improved through incorporation

  3. Newton's gift how Sir Isaac Newton unlocked the system of the world

    CERN Document Server

    Berlinski, David

    2000-01-01

    Sir Isaac Newton, creator of the first and perhaps most important scientific theory, is a giant of the scientific era. Despite this, he has remained inaccessible to most modern readers, indisputably great but undeniably remote. In this witty, engaging, and often moving examination of Newton's life, David Berlinski recovers the man behind the mathematical breakthroughs. The story carries the reader from Newton's unremarkable childhood to his awkward undergraduate days at Cambridge through the astonishing year in which, working alone, he laid the foundation for his system of the world, his Principia Mathematica, and to the subsequent monumental feuds that poisoned his soul and wearied his supporters. An edifying appreciation of Newton's greatest accomplishment, Newton's Gift is also a touching celebration of a transcendent man.

  4. A System-level Infrastructure for Multi-dimensional MP-SoC Design Space Co-exploration

    NARCIS (Netherlands)

    Jia, Z.J.; Bautista, T.; Nunez, A.; Pimentel, A.D.; Thompson, M.

    2013-01-01

    In this article, we present a flexible and extensible system-level MP-SoC design space exploration (DSE) infrastructure, called NASA. This highly modular framework uses well-defined interfaces to easily integrate different system-level simulation tools as well as different combinations of search

  5. Dynamics analysis of SIR epidemic model with correlation coefficients and clustering coefficient in networks.

    Science.gov (United States)

    Zhang, Juping; Yang, Chan; Jin, Zhen; Li, Jia

    2018-07-14

    In this paper, the correlation coefficients between nodes in states are used as dynamic variables, and we construct SIR epidemic dynamic models with correlation coefficients by using the pair approximation method in static networks and dynamic networks, respectively. Considering the clustering coefficient of the network, we analytically investigate the existence and the local asymptotic stability of each equilibrium of these models and derive threshold values for the prevalence of diseases. Additionally, we obtain two equivalent epidemic thresholds in dynamic networks, which are compared with the results of the mean field equations. Copyright © 2018 Elsevier Ltd. All rights reserved.

  6. Optimizing Real-Time Vaccine Allocation in a Stochastic SIR Model.

    Directory of Open Access Journals (Sweden)

    Chantal Nguyen

    Full Text Available Real-time vaccination following an outbreak can effectively mitigate the damage caused by an infectious disease. However, in many cases, available resources are insufficient to vaccinate the entire at-risk population, logistics result in delayed vaccine deployment, and the interaction between members of different cities facilitates a wide spatial spread of infection. Limited vaccine, time delays, and interaction (or coupling of cities lead to tradeoffs that impact the overall magnitude of the epidemic. These tradeoffs mandate investigation of optimal strategies that minimize the severity of the epidemic by prioritizing allocation of vaccine to specific subpopulations. We use an SIR model to describe the disease dynamics of an epidemic which breaks out in one city and spreads to another. We solve a master equation to determine the resulting probability distribution of the final epidemic size. We then identify tradeoffs between vaccine, time delay, and coupling, and we determine the optimal vaccination protocols resulting from these tradeoffs.

  7. External events analysis for the Savannah River Site K reactor

    International Nuclear Information System (INIS)

    Brandyberry, M.D.; Wingo, H.E.

    1990-01-01

    The probabilistic external events analysis performed for the Savannah River Site K-reactor PRA considered many different events which are generally perceived to be ''external'' to the reactor and its systems, such as fires, floods, seismic events, and transportation accidents (as well as many others). Events which have been shown to be significant contributors to risk include seismic events, tornados, a crane failure scenario, fires and dam failures. The total contribution to the core melt frequency from external initiators has been found to be 2.2 x 10 -4 per year, from which seismic events are the major contributor (1.2 x 10 -4 per year). Fire initiated events contribute 1.4 x 10 -7 per year, tornados 5.8 x 10 -7 per year, dam failures 1.5 x 10 -6 per year and the crane failure scenario less than 10 -4 per year to the core melt frequency. 8 refs., 3 figs., 5 tabs

  8. NPP unusual events: data, analysis and application

    International Nuclear Information System (INIS)

    Tolstykh, V.

    1990-01-01

    Subject of the paper are the IAEA cooperative patterns of unusual events data treatment and utilization of the operating safety experience feedback. The Incident Reporting System (IRS) and the Analysis of Safety Significant Event Team (ASSET) are discussed. The IRS methodology in collection, handling, assessment and dissemination of data on NPP unusual events (deviations, incidents and accidents) occurring during operations, surveillance and maintenance is outlined by the reports gathering and issuing practice, the experts assessment procedures and the parameters of the system. After 7 years of existence the IAEA-IRS contains over 1000 reports and receives 1.5-4% of the total information on unusual events. The author considers the reports only as detailed technical 'records' of events requiring assessment. The ASSET approaches implying an in-depth occurrences analysis directed towards level-1 PSA utilization are commented on. The experts evaluated root causes for the reported events and some trends are presented. Generally, internal events due to unexpected paths of water in the nuclear installations, occurrences related to the integrity of the primary heat transport systems, events associated with the engineered safety systems and events involving human factor represent the large groups deserving close attention. Personal recommendations on how to use the events related information use for NPP safety improvement are given. 2 tabs (R.Ts)

  9. Improvement and speed optimization of numerical tsunami modelling program using OpenMP technology

    Science.gov (United States)

    Chernov, A.; Zaytsev, A.; Yalciner, A.; Kurkin, A.

    2009-04-01

    Currently, the basic problem of tsunami modeling is low speed of calculations which is unacceptable for services of the operative notification. Existing algorithms of numerical modeling of hydrodynamic processes of tsunami waves are developed without taking the opportunities of modern computer facilities. There is an opportunity to have considerable acceleration of process of calculations by using parallel algorithms. We discuss here new approach to parallelization tsunami modeling code using OpenMP Technology (for multiprocessing systems with the general memory). Nowadays, multiprocessing systems are easily accessible for everyone. The cost of the use of such systems becomes much lower comparing to the costs of clusters. This opportunity also benefits all programmers to apply multithreading algorithms on desktop computers of researchers. Other important advantage of the given approach is the mechanism of the general memory - there is no necessity to send data on slow networks (for example Ethernet). All memory is the common for all computing processes; it causes almost linear scalability of the program and processes. In the new version of NAMI DANCE using OpenMP technology and multi-threading algorithm provide 80% gain in speed in comparison with the one-thread version for dual-processor unit. The speed increased and 320% gain was attained for four core processor unit of PCs. Thus, it was possible to reduce considerably time of performance of calculations on the scientific workstations (desktops) without complete change of the program and user interfaces. The further modernization of algorithms of preparation of initial data and processing of results using OpenMP looks reasonable. The final version of NAMI DANCE with the increased computational speed can be used not only for research purposes but also in real time Tsunami Warning Systems.

  10. Crystal Structure of MpPR-1i, a SCP/TAPS protein from Moniliophthora perniciosa, the fungus that causes Witches’ Broom Disease of Cacao

    Energy Technology Data Exchange (ETDEWEB)

    Baroni, Renata M.; Luo, Zhipu; Darwiche, Rabih; Hudspeth, Elissa M.; Schneiter, Roger; Pereira, Gonçalo A.G.; Mondego, Jorge M.C.; Asojo, Oluwatoyin A. (Fribourg); (Baylor); (NCI); (IAC-- Brazil); (UNICAMP)

    2017-08-10

    The pathogenic fungi Moniliophthora perniciosa causes Witches’ Broom Disease (WBD) of cacao. The structure of MpPR-1i, a protein expressed by M. perniciosa when it infects cacao, are presented. This is the first reported de novo structure determined by single-wavelength anomalous dispersion phasing upon soaking with selenourea. Each monomer has flexible loop regions linking the core alpha-beta-alpha sandwich topology that comprise ~50% of the structure, making it difficult to generate an accurate homology model of the protein. MpPR-1i is monomeric in solution but is packed as a high ~70% solvent content, crystallographic heptamer. The greatest conformational flexibility between monomers is found in loops exposed to the solvent channel that connect the two longest strands. MpPR-1i lacks the conserved CAP tetrad and is incapable of binding divalent cations. MpPR-1i has the ability to bind lipids, which may have roles in its infection of cacao. These lipids likely bind in the palmitate binding cavity as observed in tablysin-15, since MpPR-1i binds palmitate with comparable affinity as tablysin-15. Further studies are required to clarify the possible roles and underlying mechanisms of neutral lipid binding, as well as their effects on the pathogenesis of M. perniciosa so as to develop new interventions for WBD.

  11. PV-Powered CoMP-Based Green Cellular Networks with a Standby Grid Supply

    Directory of Open Access Journals (Sweden)

    Abu Jahid

    2017-01-01

    Full Text Available This paper proposes a novel framework for PV-powered cellular networks with a standby grid supply and an essential energy management technique for achieving envisaged green networks. The proposal considers an emerging cellular network architecture employing two types of coordinated multipoint (CoMP transmission techniques for serving the subscribers. Under the proposed framework, each base station (BS is powered by an individual PV solar energy module having an independent storage device. BSs are also connected to the conventional grid supply for meeting additional energy demand. We also propose a dynamic inter-BS solar energy sharing policy through a transmission line for further greening the proposed network by minimizing the consumption from the grid supply. An extensive simulation-based study in the downlink of a Long-Term Evolution (LTE cellular system is carried out for evaluating the energy efficiency performance of the proposed framework. System performance is also investigated for identifying the impact of various system parameters including storage factor, storage capacity, solar generation capacity, transmission line loss, and different CoMP techniques.

  12. Spontaneous closure of the idiopathic macular hole. Follow-up of this case by optical coherence tomography and microperimetry MP1

    International Nuclear Information System (INIS)

    Molina Martin, Julio Cesar; Rodriguez Rodriguez, Violeta; Mendoza Santiesteban, Carlos

    2010-01-01

    The case of spontaneous closure of a stage 4 idiopathic macular hole at followed up by Optical Coherence Tomography and microperimetry MP1 before and after the closure was presented. The spontaneous closure of a stage 4 macular hole is rare but it can occur in patients with hole upper diameters less than 150 μm. The OCT and the microperimetry MP1 are very useful tools in the diagnosis, prognosis and follow-up of this maculopathy

  13. Efficient Programming for Multicore Processor Heterogeneity: OpenMP versus OmpSs

    OpenAIRE

    Butko , Anastasiia; Bruguier , Florent; Gamatié , Abdoulaye; Sassatelli , Gilles

    2017-01-01

    International audience; ARM single-ISA heterogeneous multicore processors combine high-performance big cores with power-efficient small cores. They aim at achieving a suitable balance between performance and energy. How- ever, a main challenge is to program such architectures so as to efficiently exploit their features. In this paper, we study the impact on performance and energy trade-offs of single-ISA architecture according to OpenMP 3.0 and the OmpSs programming models. We consider differ...

  14. Resource Letter MP-2: The Manhattan project and related nuclear research

    Science.gov (United States)

    Reed, B. Cameron

    2011-02-01

    This Resource Letter is a supplement to my earlier Resource Letter MP-1 and provides further sources on the Manhattan Project and related nuclear research. Books and journal articles are cited for the following topics: General works, technical works, biographical and autobiographical works, foreign wartime programs and allied intelligence, technical papers of historical interest, and postwar policy and technical developments. I also give a list of videos and websites dealing with the Manhattan Project, nuclear weapons, and nuclear issues.

  15. PERAN MP3EI BERBASIS ”NOT BUSINESS AS USUAL” UNTUK MENINGKATKAN DAYA SAING DAN PENYERAPAN TENAGA KERJA

    Directory of Open Access Journals (Sweden)

    Hardiansyah Nur Sahaya

    2015-12-01

    Full Text Available Indonesia, as a developing country, is currently facing a tremendous challenge. Global era can be an opportunity, a challenge, as well as a threat. In this globalization era, known as economic liberalization or free trade in services in particular labor. Indonesian workers are expected to be able to compete with workers from other countries. To meet the challenges of globalization workforce, the government has prepared MP3EI (Master Plan for the Acceleration and Expansion of Indonesia's Economic Development which is not based on common business. MP3EI is a government program that is made by considering the various advantages and potential, as well as the development challenges that Indonesia must face. However, in the implementation of the strategic role of MP3EI, there are still problems in terms of human resources, science and technology. Education focuses mainly on Java, less access to education, use of science and technology training, lack of infrastructure investment training. Therefore, we need a concrete solution in optimizing regional autonomy to address the education gap in each corridor, develop the concept of "one corridor, one potential school corridor". This concept is expected to optimize each economic corridor, regeneration and gradual training for cadres training centers, increasing government and private partnership (PPP in infrastructure investment in training through the implementation of regional autonomy.Indonesia sebagai bangsa yang sedang membangun, saat ini sedang menghadapi tantangan yang luar biasa. Era global dapat menjadi peluang, tantangan, sekaligus juga menjadi ancaman. Dalam era globalisasi yang dikenal dengan liberalisasi ekonomi atau perdagangan bebas khususnya bidang jasa tenaga kerja. Tenaga kerja Indonesia dituntut harus mampu bersaing dengan tenaga kerja dari negara lain. Untuk menjawab tantangan globalisasi tenaga kerja yang ada, pemerintah telah menyiapkan MP3EI (Masterplan Percepatan dan Perluasan

  16. Approaching the theoretical limit in periodic local MP2 calculations with atomic-orbital basis sets: the case of LiH.

    Science.gov (United States)

    Usvyat, Denis; Civalleri, Bartolomeo; Maschio, Lorenzo; Dovesi, Roberto; Pisani, Cesare; Schütz, Martin

    2011-06-07

    The atomic orbital basis set limit is approached in periodic correlated calculations for solid LiH. The valence correlation energy is evaluated at the level of the local periodic second order Møller-Plesset perturbation theory (MP2), using basis sets of progressively increasing size, and also employing "bond"-centered basis functions in addition to the standard atom-centered ones. Extended basis sets, which contain linear dependencies, are processed only at the MP2 stage via a dual basis set scheme. The local approximation (domain) error has been consistently eliminated by expanding the orbital excitation domains. As a final result, it is demonstrated that the complete basis set limit can be reached for both HF and local MP2 periodic calculations, and a general scheme is outlined for the definition of high-quality atomic-orbital basis sets for solids. © 2011 American Institute of Physics

  17. Evaluate dry deposition velocity of the nitrogen oxides using Noah-MP physics ensemble simulations for the Dinghushan Forest, Southern China

    Science.gov (United States)

    Zhang, Qi; Chang, Ming; Zhou, Shengzhen; Chen, Weihua; Wang, Xuemei; Liao, Wenhui; Dai, Jianing; Wu, ZhiYong

    2017-11-01

    There has been a rapid growth of reactive nitrogen (Nr) deposition over the world in the past decades. The Pearl River Delta region is one of the areas with high loading of nitrogen deposition. But there are still large uncertainties in the study of dry deposition because of its complex processes of physical chemistry and vegetation physiology. At present, the forest canopy parameterization scheme used in WRF-Chem model is a single-layer "big leaf" model, and the simulation of radiation transmission and energy balance in forest canopy is not detailed and accurate. Noah-MP land surface model (Noah-MP) is based on the Noah land surface model (Noah LSM) and has multiple parametric options to simulate the energy, momentum, and material interactions of the vegetation-soil-atmosphere system. Therefore, to investigate the improvement of the simulation results of WRF-Chem on the nitrogen deposition in forest area after coupled with Noah-MP model and to reduce the influence of meteorological simulation biases on the dry deposition velocity simulation, a dry deposition single-point model coupled by Noah- MP and the WRF-Chem dry deposition module (WDDM) was used to simulate the deposition velocity (Vd). The model was driven by the micro-meteorological observation of the Dinghushan Forest Ecosystem Location Station. And a series of numerical experiments were carried out to identify the key processes influencing the calculation of dry deposition velocity, and the effects of various surface physical and plant physiological processes on dry deposition were discussed. The model captured the observed Vd well, but still underestimated the Vd. The self-defect of Wesely scheme applied by WDDM, and the inaccuracy of built-in parameters in WDDM and input data for Noah-MP (e.g. LAI) were the key factors that cause the underestimation of Vd. Therefore, future work is needed to improve model mechanisms and parameterization.

  18. Experimental investigation of cooling performance of a novel HVAC system combining natural ventilation with diffuse ceiling inlet and TABS

    DEFF Research Database (Denmark)

    Yu, Tao; Heiselberg, Per Kvols; Lei, Bo

    2015-01-01

    Highlights •An experimental investigation of cooling performance of a combined HVAC system is carried out. •Cooling performance of TABS with and without the influence of diffuse ceiling is analyzed. •Radiant and convective heat transfer coefficients of TABS cooling are studied. •Cooling components...

  19. Hybrid RHF/MP2 geometry optimizations with the effective fragment molecular orbital method

    DEFF Research Database (Denmark)

    Christensen, A. S.; Svendsen, Casper Steinmann; Fedorov, D. G.

    2014-01-01

    while the rest of the system is treated at the RHF level. MP2 geometry optimization is found to lower the barrier by up to 3.5 kcal/mol compared to RHF optimzations and ONIOM energy refinement and leads to a smoother convergence with respect to the basis set for the reaction profile. For double zeta...

  20. Shuttle imaging radar-A (SIR-A) data analysis. [geology of the Ozark Plateau of southern Missouri, land use in western Illinois, and vegetation types at Koonamore Station, Australia

    Science.gov (United States)

    Arvidson, R. E.

    1983-01-01

    The utility of shuttle imaging radar (SIR-A) data was evaluated in several geological and environmental contexts. For the Ozark Plateau of southern Missouri, SIR-A data were of little use in mapping structural features, because of generally uniform returns. For western Illinois, little was to be gained in terms of identifying land use categories by examining differences between overlapping passes. For southern Australia (Koonamore Station), information ion vegetation types that was not obtainable from LANDSAT MSS data alone was obtained. Specifically, high SIR-A returns in the Australian site were found to correlate with locations where shrubs increase surface roughness appreciably. The Australian study site results demonstrate the synergy of acquiring spectral reflectance and radar data over the same location and time. Such data are especially important in that region, since grazing animals have substantially altered and are continuing to alter the distribution of shrublands, grasslands, and soil exposures. Periodic, synoptic acquisition of MSS and SAR data would be of use in monitoring the dynamics of land-cover change in this environment.