WorldWideScience

Sample records for mouse open field

  1. Four factors underlying mouse behavior in an open field.

    Science.gov (United States)

    Tanaka, Shoji; Young, Jared W; Halberstadt, Adam L; Masten, Virginia L; Geyer, Mark A

    2012-07-15

    The observation of the locomotor and exploratory behaviors of rodents in an open field is one of the most fundamental methods used in the field of behavioral pharmacology. A variety of behaviors can be recorded automatically and can readily generate a multivariate pattern of pharmacological effects. Nevertheless, the optimal ways to characterize observed behaviors and concomitant drug effects are still under development. The aim of this study was to extract meaningful behavioral factors that could explain variations in the observed variables from mouse exploration. Behavioral data were recorded from male C57BL/6J mice (n=268) using the Behavioral Pattern Monitor (BPM). The BPM data were subjected to the exploratory factor analysis. The factor analysis extracted four factors: activity, sequential organization, diversive exploration, and inspective exploration. The activity factor and the two types of exploration factors correlated positively with one another, while the sequential organization factor negatively correlated with the remaining factors. The extracted factor structure constitutes a behavioral model of mouse exploration. This model will provide a platform on which one can assess the effects of psychoactive drugs and genetic manipulations on mouse exploratory behavior. Further studies are currently underway to examine the factor structure of similar multivariate data sets from humans tested in a human BPM. Copyright © 2012 Elsevier B.V. All rights reserved.

  2. Open field modifications needed to measure, in the mouse, exploration- driven ambulation and fear of open space.

    OpenAIRE

    Vidal Gómez, José

    2014-01-01

    The open field test is used to assess ambulation and anxiety; one way to assess anxiety is to compare ambulation in the center with ambulation in the periphery: the more anxious is the mouse, the less it moves in the center. The results of this report cast doubts on the generality of that rule, because they show that ambulation, both in the center and in the periphery, depends on the mouse strain and on the size of the open field; specifically, in a brightly lit open-field of moderate size (3...

  3. Open-field mouse brain PET: design optimisation and detector characterisation.

    Science.gov (United States)

    Kyme, Andre Z; Judenhofer, Martin S; Gong, Kuang; Bec, Julien; Selfridge, Aaron; Du, Junwei; Qi, Jinyi; Cherry, Simon R; Meikle, Steven R

    2017-07-13

    'Open-field' PET, in which an animal is free to move within an enclosed space during imaging, is a very promising advance for neuroscientific research. It provides a key advantage over conventional imaging under anesthesia by enabling functional changes in the brain to be correlated with an animal's behavioural response to environmental or pharmacologic stimuli. Previously we have demonstrated the feasibility of open-field imaging of rats using motion compensation techniques applied to a commercially available PET scanner. However, this approach of 'retro-fitting' motion compensation techniques to an existing system is limited by the inherent geometric and performance constraints of the system. The goal of this project is to develop a purpose-built PET scanner with geometry, motion tracking and imaging performance tailored and optimised for open-field imaging of the mouse brain. The design concept is a rail-based sliding tomograph which moves according to the animal's motion. Our specific aim in this work was to evaluate candidate scanner designs and characterise the performance of a depth-of-interaction detector module for the open-field system. We performed Monte Carlo simulations to estimate and compare the sensitivity and spatial resolution performance of four scanner geometries: a ring, parallel plate, and two box variants. Each system was based on a detector block consisting of a 23  ×  23 array of 0.785  ×  0.785  ×  20 mm 3 LSO crystals (overall dim. 19.6  ×  19.6  ×  20 mm). We found that a DoI resolution capability of 3 mm was necessary to achieve approximately uniform sub-millimetre spatial resolution throughout the FoV for all scanners except the parallel-plate geometry. With this DoI performance, the sensitivity advantage afforded by the box geometry with overlapping panels (16% peak absolute sensitivity, a 36% improvement over the ring design) suggests this unconventional design is best suited for

  4. Open-field mouse brain PET: design optimisation and detector characterisation

    Science.gov (United States)

    Kyme, Andre Z.; Judenhofer, Martin S.; Gong, Kuang; Bec, Julien; Selfridge, Aaron; Du, Junwei; Qi, Jinyi; Cherry, Simon R.; Meikle, Steven R.

    2017-08-01

    Open-field’ PET, in which an animal is free to move within an enclosed space during imaging, is a very promising advance for neuroscientific research. It provides a key advantage over conventional imaging under anesthesia by enabling functional changes in the brain to be correlated with an animal’s behavioural response to environmental or pharmacologic stimuli. Previously we have demonstrated the feasibility of open-field imaging of rats using motion compensation techniques applied to a commercially available PET scanner. However, this approach of ‘retro-fitting’ motion compensation techniques to an existing system is limited by the inherent geometric and performance constraints of the system. The goal of this project is to develop a purpose-built PET scanner with geometry, motion tracking and imaging performance tailored and optimised for open-field imaging of the mouse brain. The design concept is a rail-based sliding tomograph which moves according to the animal’s motion. Our specific aim in this work was to evaluate candidate scanner designs and characterise the performance of a depth-of-interaction detector module for the open-field system. We performed Monte Carlo simulations to estimate and compare the sensitivity and spatial resolution performance of four scanner geometries: a ring, parallel plate, and two box variants. Each system was based on a detector block consisting of a 23  ×  23 array of 0.785  ×  0.785  ×  20 mm3 LSO crystals (overall dim. 19.6  ×  19.6  ×  20 mm). We found that a DoI resolution capability of 3 mm was necessary to achieve approximately uniform sub-millimetre spatial resolution throughout the FoV for all scanners except the parallel-plate geometry. With this DoI performance, the sensitivity advantage afforded by the box geometry with overlapping panels (16% peak absolute sensitivity, a 36% improvement over the ring design) suggests this unconventional design is best

  5. The relation between open-field and emergence tests in a hyperactive mouse model.

    Science.gov (United States)

    Lalonde, R; Strazielle, C

    2009-12-01

    The relation between open-field and emergence tests was examined in mice with idiopathic hypertension. Spontaneous hypertensive mice (SHM) crossed more segments and reared more often in the open-field than normotensive controls at both age levels. In contrast, grooming episodes decreased only in the older SHM cohort. While young SHM emerged more quickly from a toy object only partially, complete emergence was faster only in the older SHM cohort. In the entire series, open-field segments were inversely correlated with 2- and 4-paw emergence latencies. There was also an inverse correlation between rears and 2-paw emergence but a positive correlation between grooming episodes and both types of emergence. In view of its association with open-field activity, the emergence test may have value in screening potential ADHD therapies.

  6. Hyperactive behaviour in the mouse model of mucopolysaccharidosis IIIB in the open field and home cage environments.

    Science.gov (United States)

    Langford-Smith, A; Malinowska, M; Langford-Smith, K J; Wegrzyn, G; Jones, S; Wynn, R; Wraith, J E; Wilkinson, F L; Bigger, B W

    2011-08-01

    Mucopolysaccharidosis IIIB (MPS IIIB) is a lysosomal storage disorder characterized by severe behavioural disturbances and progressive loss of cognitive and motor function. There is no effective treatment, but behavioural testing is a valuable tool to assess neurodegeneration and the effect of novel therapies in mouse models of disease. Several groups have evaluated behaviour in this model, but the data are inconsistent, often conflicting with patient natural history. We hypothesize that this discrepancy could be due to differences in open field habituation and home cage behaviour. Eight-month-old wild-type and MPS IIIB mice were tested in a 1-h open field test, performed 1.5 h after lights on, and a 24-h home cage behaviour test performed after 24 h of acclimatization. In the 1-h test, MPS IIIB mice were hyperactive, with increased rapid exploratory behaviour and reduced immobility time. No differences in anxiety were seen. Over the course of the test, differences became more pronounced with maximal effects at 1 h. The 24-hour home cage test was less reliable. There was evidence of increased hyperactivity in MPS IIIB mice, however, immobility was also increased, suggesting a level of inconsistency in this test. Performance of open field analysis within 1-2 h after lights on is probably critical to achieving maximal success as MPS IIIB mice have a peak in activity around this time. The open field test effectively identifies hyperactive behaviour in MPS IIIB mice and is a significant tool for evaluating effects of therapy on neurodegeneration. © 2011 The Authors. Genes, Brain and Behavior © 2011 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society.

  7. Knots: attractive places with high path tortuosity in mouse open field exploration.

    Directory of Open Access Journals (Sweden)

    Anna Dvorkin

    2010-01-01

    Full Text Available When introduced into a novel environment, mammals establish in it a preferred place marked by the highest number of visits and highest cumulative time spent in it. Examination of exploratory behavior in reference to this "home base" highlights important features of its organization. It might therefore be fruitful to search for other types of marked places in mouse exploratory behavior and examine their influence on overall behavior.Examination of path curvatures of mice exploring a large empty arena revealed the presence of circumscribed locales marked by the performance of tortuous paths full of twists and turns. We term these places knots, and the behavior performed in them-knot-scribbling. There is typically no more than one knot per session; it has distinct boundaries and it is maintained both within and across sessions. Knots are mostly situated in the place of introduction into the arena, here away from walls. Knots are not characterized by the features of a home base, except for a high speed during inbound and a low speed during outbound paths. The establishment of knots is enhanced by injecting the mouse with saline and placing it in an exposed portion of the arena, suggesting that stress and the arousal associated with it consolidate a long-term contingency between a particular locale and knot-scribbling.In an environment devoid of proximal cues mice mark a locale associated with arousal by twisting and turning in it. This creates a self-generated, often centrally located landmark. The tortuosity of the path traced during the behavior implies almost concurrent multiple views of the environment. Knot-scribbling could therefore function as a way to obtain an overview of the entire environment, allowing re-calibration of the mouse's locale map and compass directions. The rich vestibular input generated by scribbling could improve the interpretation of the visual scene.

  8. QTL and systems genetics analysis of mouse grooming and behavioral responses to novelty in an open field.

    Science.gov (United States)

    Delprato, A; Algéo, M-P; Bonheur, B; Bubier, J A; Lu, L; Williams, R W; Chesler, E J; Crusio, W E

    2017-11-01

    The open field is a classic test used to assess exploratory behavior, anxiety and locomotor activity in rodents. Here, we mapped quantitative trait loci (QTLs) underlying behaviors displayed in an open field, using a panel of 53 BXD recombinant inbred mouse strains with deep replication (10 per strain and sex). The use of these strains permits the integration and comparison of data obtained in different laboratories, and also offers the possibility to study trait covariance by exploiting powerful bioinformatics tools and resources. We quantified behavioral traits during 20-min test sessions including (1) percent time spent and distance traveled near the wall (thigmotaxis), (2) leaning against the wall, (3) rearing, (4) jumping, (5) grooming duration, (6) grooming frequency, (7) locomotion and (8) defecation. All traits exhibit moderate heritability making them amenable to genetic analysis. We identified a significant QTL on chromosome M.m. 4 at approximately 104 Mb that modulates grooming duration in both males and females (likelihood ratio statistic values of approximately 18, explaining 25% and 14% of the variance, respectively) and a suggestive QTL modulating locomotion that maps to the same locus. Bioinformatic analysis indicates Disabled 1 (Dab1, a key protein in the reelin signaling pathway) as a particularly strong candidate gene modulating these behaviors. We also found 2 highly suggestive QTLs for a sex by strain interaction for grooming duration on chromosomes 13 and 17. In addition, we identified a pairwise epistatic interaction between loci on chromosomes 12 at 36-37 Mb and 14 at 34-36 Mb that influences rearing frequency in males. © 2017 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.

  9. Between and within laboratory reliability of mouse behaviour recorded in home-cage and open-field.

    Science.gov (United States)

    Robinson, Lianne; Spruijt, Berry; Riedel, Gernot

    2018-04-15

    Reproducibility of behavioural findings between laboratories is difficult due to behaviour being sensitive to environmental factors and interactions with genetics. The objective of this study was to investigate reproducibility of behavioural data between laboratories using the PhenoTyper home cage observation system and within laboratory reproducibility using different lighting regimes. The ambulatory activity of C57BL/6 and DBA/2 mice was tested in PhenoTypers in two laboratories under near identical housing and testing conditions (Exp. 1). Additionally activity and anxiety were also assessed in the open-field test. Furthermore, testing in either a normal or inverted light/dark cycle was used to determine effects of lighting regime in a within-laboratory comparison in Aberdeen (Exp. 2). Using the PhenoTyper similar circadian rhythms were observed across laboratories. Higher levels of baseline and novelty-induced activity were evident in Aberdeen compared to Utrecht although strain differences were consistent between laboratories. Open field activity was also similar across laboratories whereas strain differences in anxiety were different. Within laboratory analysis of different lighting regimes revealed that behaviour of the mice was sensitive to changes in lighting. Utilisation of a home cage observation system facilitates the reproducibility of activity but not anxiety-related behaviours across laboratories by eliminating environmental factors known to influence reproducibility in standard behavioural tests. Standardisation of housing/test conditions resulted in reproducibility of home cage and open field activity but not anxiety-related phenotypes across laboratories with some behaviours more sensitive to environmental factors. Environmental factors include lighting and time of day. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Reduction in open field activity in the absence of memory deficits in the AppNL-G-F knock-in mouse model of Alzheimer's disease.

    Science.gov (United States)

    Whyte, Lauren S; Hemsley, Kim M; Lau, Adeline A; Hassiotis, Sofia; Saito, Takashi; Saido, Takaomi C; Hopwood, John J; Sargeant, Timothy J

    2018-01-15

    The recent development of knock-in mouse models of Alzheimer's disease provides distinct advantages over traditional transgenic mouse models that rely on over-expression of amyloid precursor protein. Two such knock-in models that have recently been widely adopted by Alzheimer's researchers are the App NL-F and App NL-G-F mice. This study aimed to further characterise the behavioural phenotype and amyloid plaque distribution of App NL-G-F/NL-G-F (C57BL/6J background) mice at six-months of age. An attempt to replicate a previous study that observed deficits in working memory in the Y-maze, showed no difference between App NL-G-F/NL-G-F and wild-type mice. Further assessment of these mice using the novel object recognition test and Morris water maze also revealed no differences between App NL-G-F/NL-G-F and wild-type mice. Despite a lack of demonstrated cognitive deficits, we report a reduction in locomotor/exploratory activity in an open field. Histological examination of App NL-G-F/NL-G-F mice showed widespread distribution of amyloid plaques at this age. We conclude that whilst at six-months of age, memory deficits are not sufficiently robust to be replicated in varying environments, amyloid plaque burden is significant in App NL-G-F/NL-G-F knock-in brain. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Variation in the timing of reproduction of the four-striped field mouse ...

    African Journals Online (AJOL)

    Variation in the timing of reproduction of the four-striped field mouse, Rhabdomys pumilio , in ... Open Access DOWNLOAD FULL TEXT ... We used the four-striped field mouse, Rhabdomys pumilio (Sparrmann, 1784), to test the hypothesis that ...

  12. Field studies courses open

    Science.gov (United States)

    Fourteen month-long courses combining applied academics with training in field research methodology are being offered this summer by the School for Field Studies. The courses, held in eight countries during May, June, July, and August, provide unique opportunities for participants to work as a team under primitive conditions.‘Our courses bind together the academic challenge of the research problem, the physical challenge of the site itself, and the interpersonal challenge of the expedition team in a dynamic way so that both cognitive and affective learning are accelerated,’ according to Jim Elder, the school's director.

  13. Behavioral consequences of radiation exposure to simulated space radiation in the C57BL/6 mouse: open field, rotorod, and acoustic startle

    Science.gov (United States)

    Pecaut, Michael J.; Haerich, Paul; Zuccarelli, Cara N.; Smith, Anna L.; Zendejas, Eric D.; Nelson, Gregory A.

    2002-01-01

    Two experiments were carried out to investigate the consequences of exposure to proton radiation, such as might occur for astronauts during space flight. C57BL/6 mice were exposed, either with or without 15-g/cm2 aluminum shielding, to 0-, 3-, or 4-Gy proton irradiation mimicking features of a solar particle event. Irradiation produced transient direct deficits in open-field exploratory behavior and acoustic startle habituation. Rotorod performance at 18 rpm was impaired by exposure to proton radiation and was impaired at 26 rpm, but only for mice irradiated with shielding and at the 4-Gy dose. Long-term (>2 weeks) indirect deficits in open-field activity appeared as a result of impaired experiential encoding immediately following exposure. A 2-week recovery prior to testing decreased most of the direct effects of exposure, with only rotorod performance at 26 rpm being impaired. These results suggest that the performance deficits may have been mediated by radiation damage to hippocampal, cerebellar, and possibly, forebrain dopaminergic function.

  14. Assessment of mouse anxiety-like behavior in the light-dark box and open-field arena: role of equipment and procedure.

    Science.gov (United States)

    Kulesskaya, Natalia; Voikar, Vootele

    2014-06-22

    Light-dark box and open field are conventional tests for assessment of anxiety-like behavior in the laboratory mice, based on approach-avoidance conflict. However, except the basic principles, variations in the equipment and procedures are very common. Therefore, contribution of certain methodological issues in different settings was investigated. Three inbred strains (C57BL/6, 129/Sv, DBA/2) and one outbred stock (ICR) of mice were used in the experiments. An effect of initial placement of mice either in the light or dark compartment was studied in the light-dark test. Moreover, two tracking systems were applied - position of the animals was detected either by infrared sensors in square box (1/2 dark) or by videotracking in rectangular box (1/3 dark). Both approaches revealed robust and consistent strain differences in the exploratory behavior. In general, C57BL/6 and ICR mice showed reduced anxiety-like behavior as compared to 129/Sv and DBA/2 strains. However, the latter two strains differed markedly in their behavior. DBA/2 mice displayed high avoidance of the light compartment accompanied by thigmotaxis, whereas the hypoactive 129 mice spent a significant proportion of time in risk-assessment behavior at the opening between two compartments. Starting from the light side increased the time spent in the light compartment and reduced the latency to the first transition. In the open field arena, black floor promoted exploratory behavior - increased time and distance in the center and increased rearing compared to white floor. In conclusion, modifications of the apparatus and procedure had significant effects on approach-avoidance behavior in general whereas the strain rankings remained unaffected. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. Quantitative Evaluation of 3D Mouse Behaviors and Motor Function in the Open-Field after Spinal Cord Injury Using Markerless Motion Tracking

    Science.gov (United States)

    Sheets, Alison L.; Lai, Po-Lun; Fisher, Lesley C.; Basso, D. Michele

    2013-01-01

    Thousands of scientists strive to identify cellular mechanisms that could lead to breakthroughs in developing ameliorative treatments for debilitating neural and muscular conditions such as spinal cord injury (SCI). Most studies use rodent models to test hypotheses, and these are all limited by the methods available to evaluate animal motor function. This study’s goal was to develop a behavioral and locomotor assessment system in a murine model of SCI that enables quantitative kinematic measurements to be made automatically in the open-field by applying markerless motion tracking approaches. Three-dimensional movements of eight naïve, five mild, five moderate, and four severe SCI mice were recorded using 10 cameras (100 Hz). Background subtraction was used in each video frame to identify the animal’s silhouette, and the 3D shape at each time was reconstructed using shape-from-silhouette. The reconstructed volume was divided into front and back halves using k-means clustering. The animal’s front Center of Volume (CoV) height and whole-body CoV speed were calculated and used to automatically classify animal behaviors including directed locomotion, exploratory locomotion, meandering, standing, and rearing. More detailed analyses of CoV height, speed, and lateral deviation during directed locomotion revealed behavioral differences and functional impairments in animals with mild, moderate, and severe SCI when compared with naïve animals. Naïve animals displayed the widest variety of behaviors including rearing and crossing the center of the open-field, the fastest speeds, and tallest rear CoV heights. SCI reduced the range of behaviors, and decreased speed (r = .70 pstudies are conducted. By providing scientists with sensitive, quantitative measurement methods, subjectivity and human error is reduced, potentially providing insights leading to breakthroughs in treating human disease. PMID:24058586

  16. Open-field test site

    Science.gov (United States)

    Gyoda, Koichi; Shinozuka, Takashi

    1995-06-01

    An open-field test site with measurement equipment, a turn table, antenna positioners, and measurement auxiliary equipment was remodelled at the CRL north-site. This paper introduces the configuration, specifications and characteristics of this new open-field test site. Measured 3-m and 10-m site attenuations are in good agreement with theoretical values, and this means that this site is suitable for using 3-m and 10-m method EMI/EMC measurements. The site is expected to be effective for antenna measurement, antenna calibration, and studies on EMI/EMC measurement methods.

  17. Quantitative evaluation of 3D mouse behaviors and motor function in the open-field after spinal cord injury using markerless motion tracking.

    Science.gov (United States)

    Sheets, Alison L; Lai, Po-Lun; Fisher, Lesley C; Basso, D Michele

    2013-01-01

    Thousands of scientists strive to identify cellular mechanisms that could lead to breakthroughs in developing ameliorative treatments for debilitating neural and muscular conditions such as spinal cord injury (SCI). Most studies use rodent models to test hypotheses, and these are all limited by the methods available to evaluate animal motor function. This study's goal was to develop a behavioral and locomotor assessment system in a murine model of SCI that enables quantitative kinematic measurements to be made automatically in the open-field by applying markerless motion tracking approaches. Three-dimensional movements of eight naïve, five mild, five moderate, and four severe SCI mice were recorded using 10 cameras (100 Hz). Background subtraction was used in each video frame to identify the animal's silhouette, and the 3D shape at each time was reconstructed using shape-from-silhouette. The reconstructed volume was divided into front and back halves using k-means clustering. The animal's front Center of Volume (CoV) height and whole-body CoV speed were calculated and used to automatically classify animal behaviors including directed locomotion, exploratory locomotion, meandering, standing, and rearing. More detailed analyses of CoV height, speed, and lateral deviation during directed locomotion revealed behavioral differences and functional impairments in animals with mild, moderate, and severe SCI when compared with naïve animals. Naïve animals displayed the widest variety of behaviors including rearing and crossing the center of the open-field, the fastest speeds, and tallest rear CoV heights. SCI reduced the range of behaviors, and decreased speed (r = .70 p<.005) and rear CoV height (r = .65 p<.01) were significantly correlated with greater lesion size. This markerless tracking approach is a first step toward fundamentally changing how rodent movement studies are conducted. By providing scientists with sensitive, quantitative measurement methods

  18. Quantitative evaluation of 3D mouse behaviors and motor function in the open-field after spinal cord injury using markerless motion tracking.

    Directory of Open Access Journals (Sweden)

    Alison L Sheets

    Full Text Available Thousands of scientists strive to identify cellular mechanisms that could lead to breakthroughs in developing ameliorative treatments for debilitating neural and muscular conditions such as spinal cord injury (SCI. Most studies use rodent models to test hypotheses, and these are all limited by the methods available to evaluate animal motor function. This study's goal was to develop a behavioral and locomotor assessment system in a murine model of SCI that enables quantitative kinematic measurements to be made automatically in the open-field by applying markerless motion tracking approaches. Three-dimensional movements of eight naïve, five mild, five moderate, and four severe SCI mice were recorded using 10 cameras (100 Hz. Background subtraction was used in each video frame to identify the animal's silhouette, and the 3D shape at each time was reconstructed using shape-from-silhouette. The reconstructed volume was divided into front and back halves using k-means clustering. The animal's front Center of Volume (CoV height and whole-body CoV speed were calculated and used to automatically classify animal behaviors including directed locomotion, exploratory locomotion, meandering, standing, and rearing. More detailed analyses of CoV height, speed, and lateral deviation during directed locomotion revealed behavioral differences and functional impairments in animals with mild, moderate, and severe SCI when compared with naïve animals. Naïve animals displayed the widest variety of behaviors including rearing and crossing the center of the open-field, the fastest speeds, and tallest rear CoV heights. SCI reduced the range of behaviors, and decreased speed (r = .70 p<.005 and rear CoV height (r = .65 p<.01 were significantly correlated with greater lesion size. This markerless tracking approach is a first step toward fundamentally changing how rodent movement studies are conducted. By providing scientists with sensitive, quantitative

  19. Connexin31.1 deficiency in the mouse impairs object memory and modulates open-field exploration, acetylcholine esterase levels in the striatum, and cAMP response element-binding protein levels in the striatum and piriform cortex.

    Science.gov (United States)

    Dere, E; Zheng-Fischhöfer, Q; Viggiano, D; Gironi Carnevale, U A; Ruocco, L A; Zlomuzica, A; Schnichels, M; Willecke, K; Huston, J P; Sadile, A G

    2008-05-02

    Neuronal gap junctions in the brain, providing intercellular electrotonic signal transfer, have been implicated in physiological and behavioral correlates of learning and memory. In connexin31.1 (Cx31.1) knockout (KO) mice the coding region of the Cx31.1 gene was replaced by a LacZ reporter gene. We investigated the impact of Cx31.1 deficiency on open-field exploration, the behavioral response to an odor, non-selective attention, learning and memory performance, and the levels of memory-related proteins in the hippocampus, striatum and the piriform cortex. In terms of behavior, the deletion of the Cx31.1 coding DNA in the mouse led to increased exploratory behaviors in a novel environment, and impaired one-trial object recognition at all delays tested. Despite strong Cx31.1 expression in the peripheral and central olfactory system, Cx31.1 KO mice exhibited normal behavioral responses to an odor. We found increased levels of acetylcholine esterase (AChE) and cAMP response element-binding protein (CREB) in the striatum of Cx31.1 KO mice. In the piriform cortex the Cx31.1 KO mice had an increased heterogeneity of CREB expression among neurons. In conclusion, gap-junctions featuring the Cx31.1 protein might be involved in open-field exploration as well as object memory and modulate levels of AChE and CREB in the striatum and piriform cortex.

  20. Mousetrap: An integrated, open-source mouse-tracking package.

    Science.gov (United States)

    Kieslich, Pascal J; Henninger, Felix

    2017-10-01

    Mouse-tracking - the analysis of mouse movements in computerized experiments - is becoming increasingly popular in the cognitive sciences. Mouse movements are taken as an indicator of commitment to or conflict between choice options during the decision process. Using mouse-tracking, researchers have gained insight into the temporal development of cognitive processes across a growing number of psychological domains. In the current article, we present software that offers easy and convenient means of recording and analyzing mouse movements in computerized laboratory experiments. In particular, we introduce and demonstrate the mousetrap plugin that adds mouse-tracking to OpenSesame, a popular general-purpose graphical experiment builder. By integrating with this existing experimental software, mousetrap allows for the creation of mouse-tracking studies through a graphical interface, without requiring programming skills. Thus, researchers can benefit from the core features of a validated software package and the many extensions available for it (e.g., the integration with auxiliary hardware such as eye-tracking, or the support of interactive experiments). In addition, the recorded data can be imported directly into the statistical programming language R using the mousetrap package, which greatly facilitates analysis. Mousetrap is cross-platform, open-source and available free of charge from https://github.com/pascalkieslich/mousetrap-os .

  1. Remote Laboratory and Animal Behaviour: An Interactive Open Field System

    Science.gov (United States)

    Fiore, Lorenzo; Ratti, Giovannino

    2007-01-01

    Remote laboratories can provide distant learners with practical acquisitions which would otherwise remain precluded. Our proposal here is a remote laboratory on a behavioural test (open field test), with the aim of introducing learners to the observation and analysis of stereotyped behaviour in animals. A real-time video of a mouse in an…

  2. Open magnetic fields in active regions

    International Nuclear Information System (INIS)

    Svestka, Z.; Solodyna, C.V.; Levine, R.H.

    1977-01-01

    Soft X-ray observations confirm that some of the dark gaps seen between interconnecting loops and inner cores of active regions may be loci of open fields, as it has been predicted by global potential extrapolation of photospheric magnetic fields. It seems that the field lines may open only in a later state of the active region development. (Auth.)

  3. Open Field Scoring Record No. 298

    National Research Council Canada - National Science Library

    Overbay, Jr., Larry; Robitaille, George; Fling, Rick; McClung, Christina

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. Scoring Records have been coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  4. Open Field Scoring Record No. 299

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site Open Field. Scoring Records have been coordinated by Larry Overbay and the standardized UXO Technology Demonstration Site Scoring Committee...

  5. Open-closed string correspondence in open string field theory

    International Nuclear Information System (INIS)

    Baumgartl, M.; Sachs, I.

    2008-01-01

    We address the problem of describing different closed string backgrounds in background independent open string field theory: A shift in the closed string background corresponds to a collective excitation of open strings. As an illustration we apply the formalism to the case where the closed string background is a group manifold. (Abstract Copyright [2008], Wiley Periodicals, Inc.)

  6. Topological defects in open string field theory

    Science.gov (United States)

    Kojita, Toshiko; Maccaferri, Carlo; Masuda, Toru; Schnabl, Martin

    2018-04-01

    We show how conformal field theory topological defects can relate solutions of open string field theory for different boundary conditions. To this end we generalize the results of Graham and Watts to include the action of defects on boundary condition changing fields. Special care is devoted to the general case when nontrivial multiplicities arise upon defect action. Surprisingly the fusion algebra of defects is realized on open string fields only up to a (star algebra) isomorphism.

  7. Forward Field Computation with OpenMEEG

    Directory of Open Access Journals (Sweden)

    Alexandre Gramfort

    2011-01-01

    must be computed. We present OpenMEEG, which solves the electromagnetic forward problem in the quasistatic regime, for head models with piecewise constant conductivity. The core of OpenMEEG consists of the symmetric Boundary Element Method, which is based on an extended Green Representation theorem. OpenMEEG is able to provide lead fields for four different electromagnetic forward problems: Electroencephalography (EEG, Magnetoencephalography (MEG, Electrical Impedance Tomography (EIT, and intracranial electric potentials (IPs. OpenMEEG is open source and multiplatform. It can be used from Python and Matlab in conjunction with toolboxes that solve the inverse problem; its integration within FieldTrip is operational since release 2.0.

  8. Can Polar Fields Explain Missing Open Flux?

    Science.gov (United States)

    Linker, J.; Downs, C.; Caplan, R. M.; Riley, P.; Mikic, Z.; Lionello, R.

    2017-12-01

    The "open" magnetic field is the portion of the Sun's magnetic field that extends out into the heliosphere and becomes the interplanetary magnetic field (IMF). Both the IMF and the Sun's magnetic field in the photosphere have been measured for many years. In the standard paradigm of coronal structure, the open magnetic field originates primarily in coronal holes. The regions that are magnetically closed trap the coronal plasma and give rise to the streamer belt. This basic picture is qualitatively reproduced by models of coronal structure using photospheric magnetic fields as input. If this paradigm is correct, there are two primary observational constraints on the models: (1) The open field regions in the model should approximately correspond to coronal holes observed in emission, and (2) the magnitude of the open magnetic flux in the model should match that inferred from in situ spacecraft measurements. Linker et al. (2017, ApJ, submitted) investigated the July 2010 time period for a range of observatory maps and both PFSS and MHD models. We found that all of the model/map combinations underestimated the interplanetary magnetic flux, unless the modeled open field regions were larger than observed coronal holes. An estimate of the open magnetic flux made entirely from solar observations (combining detected coronal hole boundaries with observatory synoptic magnetic maps) also underestimated the interplanetary magnetic flux. The magnetic field near the Sun's poles is poorly observed and may not be well represented in observatory maps. In this paper, we explore whether an underestimate of the polar magnetic flux during this time period could account for the overall underestimate of open magnetic flux. Research supported by NASA, AFOSR, and NSF.

  9. Thigmotactic responses in an open-field

    Directory of Open Access Journals (Sweden)

    M.R. Lamprea

    2008-02-01

    Full Text Available The goal of the present study was to investigate the role of thigmotaxis (the tendency to remain close to vertical surfaces in rat exploratory behavior in an open-field. Thigmotaxis was investigated in a parametric way, using 24 experimentally adult naive male Wistar rats (210-230 g. Exploratory behavior was studied in an open-field (N = 12 in 5-min sessions and behavior was analyzed in terms of where it occurred: in areas surrounded by two, one, or no walls. Another group of rats (N = 12 was studied in an open-field with blocks placed near two of the corners so as to make these corner areas surrounded by three walls. The floor of the open-fields was divided into 20-cm squares in order to locate the exact place of occurrence of each behavior. The following behaviors were recorded: entries into the squares, rearings, and groomings. In both types of open-field the rats chose to remain longer in the squares surrounded by the largest possible number of walls. In one of the open-fields, the mean time (seconds spent in squares surrounded by two walls was longer than the time spent in squares surrounded by one or no walls (37.2, 7.7, and 1.8 s, respectively. In the other open-field, the mean time spent in squares surrounded by three walls was longer than the time spent in squares surrounded by two, one or no walls (41.7, 20.4, 7.0, and 2.6 s, respectively. Other measures presented a similar profile. These results indicate that rats are sensitive to the number of walls in an environment and prefer to remain close to them.

  10. Open magnetic fields in active regions

    Science.gov (United States)

    Svestka, Z.; Solodyna, C. V.; Howard, R.; Levine, R. H.

    1977-01-01

    Soft X-ray images and magnetograms of several active regions and coronal holes are examined which support the interpretation that some of the dark X-ray gaps seen between interconnecting loops and inner cores of active regions are foot points of open field lines inside the active regions. Characteristics of the investigated dark gaps are summarized. All the active regions with dark X-ray gaps at the proper place and with the correct polarity predicted by global potential extrapolation of photospheric magnetic fields are shown to be old active regions, indicating that field opening is accomplished only in a late phase of active-region development. It is noted that some of the observed dark gaps probably have nothing in common with open fields, but are either due to the decreased temperature in low-lying portions of interconnecting loops or are the roots of higher and less dense or cooler loops.

  11. Open-field exposure facilitates consummatory extinction.

    Science.gov (United States)

    Justel, Nadia; Psyrdellis, Mariana; Pautassi, Ricardo M

    2016-12-07

    During extinction, the organism learns that a conditioned stimulus or a conditioned response is no longer associated with an unconditioned stimulus, and as a consequence, a decrement in the response is presented. The exposure to novel situations (e.g. exploration of a novel open field) has been used widely to modulate (i.e. either enhance or deteriorate) learning and memory. The aim of the present study was to test whether open-field exposure could modulate consummatory extinction. The results indicated that open-field exposure accelerated the extinction response (i.e. experimental animals provided novelty exposure had lower consummatory behavior than control animals) when applied before - but not after - the first extinction trial, or when applied before the second extinction trial. The results suggest that environmental treatments such as novelty exposure provide a valuable, nonpharmacological alternative to potentially modulate extinction processes.

  12. On the helicity of open magnetic fields

    International Nuclear Information System (INIS)

    Prior, C.; Yeates, A. R.

    2014-01-01

    We reconsider the topological interpretation of magnetic helicity for magnetic fields in open domains, and relate this to the relative helicity. Specifically, our domains stretch between two parallel planes, and each of these ends may be magnetically open. It is demonstrated that, while the magnetic helicity is gauge-dependent, its value in any gauge may be physically interpreted as the average winding number among all pairs of field lines with respect to some orthonormal frame field. In fact, the choice of gauge is equivalent to the choice of reference field in the relative helicity, meaning that the magnetic helicity is no less physically meaningful. We prove that a particular gauge always measures the winding with respect to a fixed frame, and propose that this is normally the best choice. For periodic fields, this choice is equivalent to measuring relative helicity with respect to a potential reference field. However, for aperiodic fields, we show that the potential field can be twisted. We prove by construction that there always exists a possible untwisted reference field.

  13. Open bosonic string in background electromagnetic field

    International Nuclear Information System (INIS)

    Nesterenko, V.V.

    1987-01-01

    The classical and quantum dynamics of an open string propagating in the D-dimensional space-time in the presence of a background electromagnetic field is investigated. An important point in this consideration is the use of the generalized light-like gauge. There are considered the strings of two types; the neutral strings with charges at their ends obeying the condition q 1 +q 2 =0 and the charged strings having a net charge q 1 +q 2 ≠ 0. The consistency of theory demands that the background electric field does not exceed its critical value. The distance between the mass levels of the neutral open string decreases (1-e 2 ) times in comparison with the free string, where e is the dimensionless strength of the electric field. The magnetic field does not affect this distance. It is shown that at a classical level the squared mass of the neutral open string has a tachyonic contribution due to the motion of the string as a whole in transverse directions. The tachyonic term disappears if one considers, instead of M 2 , the string energy in a special reference frame where the projection of the total canonical momentum of the string onto the electric field vanishes. The contributions due to zero point fluctuations to the energy spectrum of the neutral string and to the Virasoro operators in the theory of charged string are found

  14. Supersymmetry in open superstring field theory

    Energy Technology Data Exchange (ETDEWEB)

    Erler, Theodore [Arnold Sommerfeld Center, Ludwig-Maximilians University,Theresienstrasse 37, 80333 Munich (Germany)

    2017-05-19

    We realize the 16 unbroken supersymmetries on a BPS D-brane as invariances of the action of the corresponding open superstring field theory. We work in the small Hilbert space approach, where a symmetry of the action translates into a symmetry of the associated cyclic A{sub ∞} structure. We compute the supersymmetry algebra, being careful to disentangle the components which produce a translation, a gauge transformation, and a symmetry transformation which vanishes on-shell. Via the minimal model theorem, we illustrate how supersymmetry of the action implies supersymmetry of the tree level open string scattering amplitudes.

  15. TEMPORAL STRUCTURE OF OPEN-FIELD BEHAVIOR IN INBRED STRAINS OF MICE

    NARCIS (Netherlands)

    MAKINO, J; KATO, K; MAES, FW

    1991-01-01

    Behavior of the inbred mouse strains BALB, C3H, DBA and C57BL in an open field was directly observed for 10 min by a multi-event time sampling method. It was coded into nine behavioral items, the occurrence or absence of which in consecutive 5-s time bins was called a behavioral state. Fourteen

  16. Ballooning modes on open magnetic field lines

    International Nuclear Information System (INIS)

    Hameiri, E.

    1999-01-01

    The ballooning instability on open magnetic field lines is given a thorough mathematical analysis. It is shown that resistive bounding ends (endplates) induce the same stability properties as insulating ends. When unstable, the maximal growth rate increases monotonically with boundary resistivity. An interchange instability may be present, and one necessary condition for its stability is that ∫dl/B be constant on pressure surfaces. (This is an equilibrium existence condition for systems with closed magnetic field lines.) Another necessary condition for interchange stability has the same form as in the closed line case. Precise necessary and sufficient stability criteria are given for various types of bounding ends, including insulating, resistive, and perfectly conducting. copyright 1999 American Institute of Physics

  17. Plasma opening switch with extrinsic magnetic field

    CERN Document Server

    Dolgachev, G; Maslennikov, D

    2001-01-01

    Summary form only given, as follows. We have demonstrated in series of experiments that plasma opening switch (POS) switching voltage (UPOS) is defined by energy density (w) deposited in the POS plasma. If we then consider a plasma erosion mainly responsible for the effect of POS switching (the erosion effect could be described by Hall or Child-Langmuir models) the energy density (w) could be measured as a function of a system "macro-parameter" such as the initial charging voltage of the capacity storage system (the Marx pulsed voltage generator) UMarx. The POS voltage in this case could be given by UPOS"aw=aUMarx4/7, where a is a constant. This report demonstrates that for the high-impedance POS which has limited charge density transferred through the POS plasma a"2.5 (MV3/7) with no external magnetic field applied. The use of the extrinsic magnetic field allows to increase a up to 3.6 (MV3/7) and to achieve higher voltages at the opening phase - UPOS=3.6UMarx4/7. To verify this approach set of experimental ...

  18. Hidden gravity in open-string field theory

    International Nuclear Information System (INIS)

    Siegel, W.

    1994-01-01

    We clarify the nature of the graviton as a bound state in open-string field theory: The flat metric in the action appears as the vacuum value of an open string field. The bound state appears as a composite field in the free field theory

  19. Landscape history and archaeology of open field landscapes in Europe

    NARCIS (Netherlands)

    Renes, J.|info:eu-repo/dai/nl/071365303

    2016-01-01

    The landscapes of open fields were the grain baskets of medieval Europe. The term ‘open fields’ refers to the large arable fields that have an open character because the individual parcels of the owners were not surrounded by hedges, woodbanks, drystone walls or other visible boundaries. In this

  20. Effects of magnetic field exposure on open field behaviour and nociceptive responses in mice.

    Science.gov (United States)

    Del Seppia, Cristina; Mezzasalma, Lorena; Choleris, Elena; Luschi, Paolo; Ghione, Sergio

    2003-09-15

    Results of previous studies have shown that nociceptive sensitivity in male C57 mice is enhanced by exposure to a regular 37 Hz or an irregularly varying (field. In order to test whether these fields affect more generally mouse behaviour, we placed Swiss CD-1 mice in a novel environment (open field test) and exposed them for 2 h to these two different magnetic field conditions. Hence, we analysed how duration and time course of various behavioural patterns (i.e. exploration, rear, edge chew, self-groom, sit, walk and sleep) and nociceptive sensitivity had been affected by such exposure. Nociceptive sensitivity was significantly greater in magnetically treated mice than in controls. The overall time spent in exploratory activities was significantly shorter in both magnetically treated groups (time), than in controls (42%). Conversely, the time spent in sleeping was markedly longer in the treated groups (both 27% of total time) than in controls (11%). These results suggest that exposure to altered magnetic fields induce a more rapid habituation to a novel environment.

  1. Analytic solutions for marginal deformations in open superstring field theory

    International Nuclear Information System (INIS)

    Okawa, Y.

    2007-04-01

    We extend the calculable analytic approach to marginal deformations recently developed in open bosonic string field theory to open superstring field theory formulated by Berkovits. We construct analytic solutions to all orders in the deformation parameter when operator products made of the marginal operator and the associated superconformal primary field are regular. (orig.)

  2. Automatic analysis of altered gait in arylsulphatase A-deficient mice in the open field.

    Science.gov (United States)

    Leroy, Toon; Stroobants, Stijn; Aerts, Jean-Marie; D'Hooge, Rudi; Berckmans, Daniel

    2009-08-01

    In current research with laboratory animals, observing their dynamic behavior or locomotion is a labor-intensive task. Automatic continuous monitoring can provide quantitative data on each animal's condition and coordination ability. The objective of the present work is to develop an automated mouse observation system integrated with a conventional open-field test for motor function evaluation. Data were acquired from 86 mice having a targeted disruption of the arylsulphatase A (ASA) gene and having lowered coordinated locomotion abilities as a symptom. The mice used were 36 heterozygotes (12 females) and 50 knockout mice (30 females) at the age of 6 months. The mice were placed one at a time into the test setup, which consisted of a Plexiglas cage (53x34.5x26 cm) and two fluorescent bulbs for proper illumination. The transparent cage allowed images to be captured from underneath the cage, so image information could be obtained about the dynamic variation of the positions of the limbs of the mice for gait reconstruction. Every mouse was recorded for 10 min. Background subtraction and color filtering were used to measure and calculate image features, which are variables that contain crucial information, such as the mouse's position, orientation, body outline, and possible locations for the mouse's paws. A set of heuristic rules was used to prune implausible paw features and label the remaining ones as front/hind and left/right. After we had pruned the implausible paw features, the paw features that were consistent over subsequent images were matched to footprints. Finally, from the measured footprint sequence, eight parameters were calculated in order to quantify the gait of the mouse. This automatic observation technique can be integrated with a regular open-field test, where the trajectory and motor function of a free-moving mouse are measured simultaneously.

  3. Thermodynamic properties of open noncritical string in external electromagnetic field

    International Nuclear Information System (INIS)

    Lichtzier, I.M.; Odintsov, S.D.; Bytsenko, A.A.

    1991-01-01

    We investigate the thermodynamics of open noncritical string (charged and neutral) in an external constant magnetic field. The free energy and Hagedorn temperature are calculated. It is shown that Hagedorn temperature is the same as in the absence of constant magnetic field. We present also the expressions for the free energy and Hagedorn temperature of the neutral open noncritical string in an external constant electromagnetic field. In this case Hagedorn temperature depends on the external electric field. (author)

  4. Slow decay of magnetic fields in open Friedmann universes

    International Nuclear Information System (INIS)

    Barrow, John D.; Tsagas, Christos G.

    2008-01-01

    Magnetic fields in Friedmann universes can experience superadiabatic growth without departing from conventional electromagnetism. The reason is the relativistic coupling between vector fields and spacetime geometry, which slows down the decay of large-scale magnetic fields in open universes, compared to that seen in perfectly flat models. The result is a large relative gain in magnetic strength that can lead to astrophysically interesting B fields, even if our Universe is only marginally open today

  5. Pre-geometrical field theory of the open string

    International Nuclear Information System (INIS)

    Nojiri, M.M.; Nojiri, Shin'ichi

    1988-01-01

    We propose a gauge invariant, background independent string action, which contains open and closed string fields and no kinetic terms. The kinetic term is generated through the condensation of the string fields, which is the solution of the equations of motion. We solve the equations and show that the action is classically equivalent to the open string action proposed by Hata et al. (orig.)

  6. Open string in the constant B-field background

    International Nuclear Information System (INIS)

    Jing Jian; Long Zhengwen

    2005-01-01

    A new method is proposed to quantize open strings in this paper. To illustrate our method, we analyze free open string as well as open string in the D-brane background with a nonvanishing B-field, respectively. The Poisson brackets among Fourier components are obtained firstly then we get the Poisson brackets among open string's coordinates. The noncommutativity of coordinates along the D-brane is reproduced. Some ambiguities in the previous discussions can be avoided

  7. Plasma behaviors in the open field region of reversed-field theta-pinch

    International Nuclear Information System (INIS)

    Aso, Yoshiyuki; Hirano, Keiichi.

    1983-03-01

    A characteristic behavior of the plasma in an open field region of reversed field theta pinch has been studied with the guide field (GF) which extends the field line along the axial direction. The experimental result suggests that the rotaional instability may be induced in FRC after the plasma touches the wall at the ends of the open field. (author)

  8. Auditory Perception in Open Field: Distance Estimation

    Science.gov (United States)

    2013-07-01

    geocentric judgments, are based on the external frame of reference and are independent of the actual location of the observer. The location of one...viewing distance increases approaching an asymptotic ceiling (Gogel, 1993; Loomis and Philbeck, 1999). Sedgwick (1986) conducted an extensive...hypothesized that in the case of a sound source spherically radiating sound and approaching the stationary listener with a constant velocity in an open

  9. Opening the cusp. [using magnetic field topology

    Science.gov (United States)

    Crooker, N. U.; Toffoletto, F. R.; Gussenhoven, M. S.

    1991-01-01

    This paper discusses the magnetic field topology (determined by the superposition of dipole, image, and uniform fields) for mapping the cusp to the ionosphere. The model results are compared to both new and published observations and are then used to map the footprint of a flux transfer event caused by a time variation in the merging rate. It is shown that the cusp geometry distorts the field lines mapped from the magnetopause to yield footprints with dawn and dusk protrusions into the region of closed magnetic flux.

  10. Electromagnetic field for an open magnetosphere

    International Nuclear Information System (INIS)

    Heikkila, W.J.

    1984-01-01

    The boundary-layer-dominated models of the earth EM field developed by Heikkila (1975, 1978, 1982, and 1983) and Heikkila et al. (1979) to account for deficiencies in the electric-field descriptions of quasi-steady-state magnetic-field-reconnection models (such as that of Cowley, 1980) are characterized, reviewing the arguments and indicating the most important implications. The mechanisms of boundary-layer formation and field direction reversal are explained and illustrated with diagrams, and it is inferred that boundary-layer phenomena rather than magnetic reconnection may be the cause of large-scale magnetospheric circulation, convection, plasma-sheet formation and sunward convection, and auroras, the boundary layer acting basically as a viscous process mediating solar-wind/magnetosphere interactions. 23 references

  11. The electromagnetic field for an open magnetosphere

    Science.gov (United States)

    Heikkila, W. J.

    1984-01-01

    The boundary-layer-dominated models of the earth EM field developed by Heikkila (1975, 1978, 1982, and 1983) and Heikkila et al. (1979) to account for deficiencies in the electric-field descriptions of quasi-steady-state magnetic-field-reconnection models (such as that of Cowley, 1980) are characterized, reviewing the arguments and indicating the most important implications. The mechanisms of boundary-layer formation and field direction reversal are explained and illustrated with diagrams, and it is inferred that boundary-layer phenomena rather than magnetic reconnection may be the cause of large-scale magnetospheric circulation, convection, plasma-sheet formation and sunward convection, and auroras, the boundary layer acting basically as a viscous process mediating solar-wind/magnetosphere interactions.

  12. Open superstring field theory on the restricted Hilbert space

    International Nuclear Information System (INIS)

    Konopka, Sebastian; Sachs, Ivo

    2016-01-01

    It appears that the formulation of an action for the Ramond sector of open superstring field theory requires to either restrict the Hilbert space for the Ramond sector or to introduce auxiliary fields with picture −3/2. The purpose of this note is to clarify the relation of the restricted Hilbert space with other approaches and to formulate open superstring field theory entirely in the small Hilbert space.

  13. Proactive interference of open field on consummatory successive negative contrast.

    Science.gov (United States)

    Justel, Nadia; Pautassi, Ricardo; Mustaca, Alba

    2014-03-01

    Reactivity to a reward is affected by prior experience with the different reinforcer values of that reward, a phenomenon known as incentive relativity, which can be studied using the consummatory succesive negative contrast (cSNC) paradigm, in which the performance of animals that receive a 4 % sucrose solution after trials on which they were exposed to 32 % sucrose is compared with that of subjects that always receive the 4 % sucrose solution. The exploration of a novel open field can enhance or block the acquisition of associative and nonassociative memories. The effect of open field on cSNC has not yet been explored. The main result of the present study was that open-field exposure significantly modified the expression of cSNC. Exposure to an open field 1 h but not immediately before the downshift interfered with the expression of cSNC. These animals drank more of the downshifted reward than did controls that were not exposed to the apparatus, and this behavior persisted for up to three recovery trials. This phenomenon was observed even when the animals were given a more protracted preshift phase and when the discrepancy between the preshift and shift incentive values of sucrose were increased. An open field also interfered with incentive downshift when open-field exposure occurred 6 h before the downshift, and repeated exposure to the apparatus did not deteriorate this effect. The present study adds to a growing body of literature that indicates that open-field exploration can interfere with memory formation.

  14. Shear-induced opening of the coronal magnetic field

    Science.gov (United States)

    Wolfson, Richard

    1995-01-01

    This work describes the evolution of a model solar corona in response to motions of the footpoints of its magnetic field. The mathematics involved is semianalytic, with the only numerical solution being that of an ordinary differential equation. This approach, while lacking the flexibility and physical details of full MHD simulations, allows for very rapid computation along with complete and rigorous exploration of the model's implications. We find that the model coronal field bulges upward, at first slowly and then more dramatically, in response to footpoint displacements. The energy in the field rises monotonically from that of the initial potential state, and the field configuration and energy appraoch asymptotically that of a fully open field. Concurrently, electric currents develop and concentrate into a current sheet as the limiting case of the open field is approached. Examination of the equations shows rigorously that in the asymptotic limit of the fully open field, the current layer becomes a true ideal MHD singularity.

  15. On background-independent open-string field theory

    International Nuclear Information System (INIS)

    Witten, E.

    1992-01-01

    A framework for background-independent open-string field theory is proposed. The approach involves using the Batalin-Vilkovisky formalism, in a way suggested by recent developments in closed-string field theory, to implicitly define a gauge-invariant Lagrangian in a hypothetical ''space of all open-string world-sheet theories.'' It is built into the formalism that classical solutions of the string field theory are Becchi-Rouet-Stora-Tyutin- (BRST-) invariant open-string world-sheet theories and that, when expanding around a classical solution, the infinitesimal gauge transformations are generated by the world-sheet BRST operator

  16. Background Independent Open String Field Theory and Constant B-Field

    OpenAIRE

    Nemeschansky, D.; Yasnov, V.

    2000-01-01

    We calculate the background independent action for bosonic and supersymmetric open string field theory in a constant B-field. We also determine the tachyon effective action in the presence of constant B-field.

  17. Remarks on the relation between different (open) string field theories

    International Nuclear Information System (INIS)

    De Alwis, S.P.

    1987-01-01

    It is shown that the different three-string vertices, related by conformal transformations, are in the same BRST cohomology class. We use this result to discuss the relation between different (open) string field theories. (orig.)

  18. Automated gait analysis in the open-field test for laboratory mice.

    Science.gov (United States)

    Leroy, Toon; Silva, Mitchell; D'Hooge, Rudi; Aerts, Jean-Marie; Berckmans, Daniel

    2009-02-01

    In this article, an automated and accurate mouse observation method, based on a conventional test for motor function evaluation, is outlined. The proposed measurement technique was integrated in a regular open-field test, where the trajectory and locomotion of a free-moving mouse were measured simultaneously. The system setup consisted of a transparent cage and a camera placed below it with its lens pointing upward, allowing for images to be captured from underneath the cage while the mouse was walking on the transparent cage floor. Thus, additional information was obtained about the position of the limbs of the mice for gait reconstruction. In a first step, the camera was calibrated as soon as it was fixed in place. A linear calibration factor, relating distances in image coordinates to real-world dimensions, was determined. In a second step, the mouse was located and its body contour segmented from the image by subtracting a previously taken "background" image of the empty cage from the camera image. In a third step, the movement of the mouse was analyzed and its speed estimated from its location in the past few images. If the speed was above a 1-sec threshold, the mouse was recognized to be running, and the image was further processed for footprint recognition. In a fourth step, color filtering was applied within the recovered mouse region to measure the position of the mouse's paws, which were visible in the image as small pink spots. Paws that were detected at the same location in a number of subsequent images were kept as footprints-that is, paws in contact with the cage floor. The footprints were classified by their position relative to the mouse's outline as corresponding to the front left or right paw or the hind left or right paw. Finally, eight parameters were calculated from the footprint pattern to describe the locomotion of the mouse: right/left overlap, front/hind base, right/left front limb stride, and right/left hind limb stride. As an application

  19. Star democracy in open string field theory

    International Nuclear Information System (INIS)

    Maccaferri, Carlo; Mamone, Davide

    2003-01-01

    We study three types of star products in Saft: the ghosts, the twisted ghosts and the matter. We find that their Neumann coefficients are related to each other in a compact way which includes the Gross-Jevicki relation between matter and ghost sector: we explicitly show that the same relation, with a minus sign, holds for the twisted and non-twisted ghosts (which are different but define the same solution). In agreement with this, we prove that matter and twisted ghost coefficients just differ by a minus sign. As a consistency check, we also compute the spectrum of the twisted ghost vertices from conformal field theory and, using equality of twisted and reduced slivers, we derive the spectrum of the non twisted ghost star. (author)

  20. Does open-field exposure during infancy influence open-field behavior of the same adult mice?

    OpenAIRE

    Vidal Gómez, José

    2013-01-01

    The goal of this report is to find out whether early exposure of mice to the open-field results in altered behavior of the same adult mice in the same open-field. Early exposure to the open-field was carried out between birth and weaning; two control groups were included: control 2 (mice exposed to a reduced dark space) and control 1 (mice left undisturbed). The (male and female) mice were of the Balb/c and C57Bl/6 strains. Adult C57Bl/6 female mice of the openfield and control 2 groups ambul...

  1. The free energies of partially open coronal magnetic fields

    Science.gov (United States)

    Low, B. C.; Smith, D. F.

    1993-01-01

    A simple model of the low corona is examined in terms of a static polytropic atmosphere in equilibrium with a global magnetic field. The question posed is whether magnetostatic states with partially open magnetic fields may contain magnetic energies in excess of those in fully open magnetic fields. Based on the analysis presented here, it is concluded that the cross-field electric currents in the pre-eruption corona are a viable source of the bulk of the energies in a mass ejection and its associated flare.

  2. Can a marginally open universe amplify magnetic fields?

    International Nuclear Information System (INIS)

    Shtanov, Yuri; Sahni, Varun

    2013-01-01

    In a series of recent papers, including arXiv:1210.1183, it was claimed that large-scale magnetic fields generated during inflation in a spatially open universe could remain astrophysically significant at the present time since they experienced superadiabatic amplification specific to an open universe. We reexamine this assertion and show that, on the contrary, large-scale magnetic fields in a realistic open universe decay in much the same manner as they would in a spatially flat universe. Consequently, their amplitude today is extremely small (B 0 ∼ −59 G) and is unlikely to be of astrophysical significance

  3. Open field locomotor activity and anxiety-related behaviors in mucopolysaccharidosis type IIIA mice.

    Science.gov (United States)

    Lau, Adeline A; Crawley, Allison C; Hopwood, John J; Hemsley, Kim M

    2008-08-05

    Mucopolysaccharidosis (MPS) IIIA, or Sanfilippo syndrome, is a lysosomal storage disorder characterized by severe and progressive neuropathology. Following an asymptomatic period, patients may present with sleep disturbances, cognitive decline, aggressive tendencies and hyperactivity. A naturally-occurring mouse model of MPS IIIA also exhibits many of these behavioral features and has been recently back-crossed onto a C57BL/6 genetic background. To more thoroughly characterize the behavioral phenotype of congenic MPS IIIA mice, we assessed exploratory activity and unconditioned anxiety-related behavior in the elevated plus maze (EPM) and open field locomotor activity. Although MPS IIIA male mice were less active in the EPM at 18 and 20 weeks of age, they were more likely to explore the open arms than their normal counter-parts suggesting reduced anxiety. Repeated EPM testing reduced exploration of the open arms in MPS IIIA mice. In the open field test, significant reductions in activity were evident in naïve-tested male MPS IIIA mice from 10 weeks of age. Female normal and MPS IIIA mice displayed similar exploratory activity in the open field test. These differences in anxiety and locomotor activity will allow us to evaluate the efficacy of therapeutic regimes for MPS IIIA as a forerunner to developing safe and effective therapies for Sanfilippo patients.

  4. A toy model for single field open inflation

    International Nuclear Information System (INIS)

    Vaudrevange, Pascal M.; Westphal, Alexander

    2012-05-01

    Inflation in an open universe produced by Coleman-De Luccia (CDL) tunneling induces a friction term that is strong enough to allow for successful small-field inflation in models that would otherwise suffer from a severe overshoot problem. In this paper, we present a polynomial scalar potential which allows for a full analysis. This provides a simple model of single-field open inflation on a small-field inflection point after tunneling. We present numerical results and compare them with analytic approximations.

  5. Parallel inhomogeneity and the Alfven resonance. 1: Open field lines

    Science.gov (United States)

    Hansen, P. J.; Harrold, B. G.

    1994-01-01

    In light of a recent demonstration of the general nonexistence of a singularity at the Alfven resonance in cold, ideal, linearized magnetohydrodynamics, we examine the effect of a small density gradient parallel to uniform, open ambient magnetic field lines. To lowest order, energy deposition is quantitatively unaffected but occurs continuously over a thickened layer. This effect is illustrated in a numerical analysis of a plasma sheet boundary layer model with perfectly absorbing boundary conditions. Consequences of the results are discussed, both for the open field line approximation and for the ensuing closed field line analysis.

  6. Evidence for open field lines in Jupiter's magnetosphere

    Science.gov (United States)

    Goertz, C. K.; Randall, B. A.; Thomsen, M. F.; Jones, D. E.; Smith, E. J.

    1976-01-01

    A model for the night-side Jovian magnetic field is derived partly on the basis of theoretical considerations and partly on the basis of the magnetic-field data obtained during the outbound leg of the path of Pioneer 10. This model can explain the observed sawtooth modulation of energetic particle fluxes in terms of closed and open field lines that cannot contain the particles. The model is applicable only to the Jovian magnetotail.

  7. Open Access Publishing in the Field of Medical Informatics.

    Science.gov (United States)

    Kuballa, Stefanie

    2017-05-01

    The open access paradigm has become an important approach in today's information and communication society. Funders and governments in different countries stipulate open access publications of funded research results. Medical informatics as part of the science, technology and medicine disciplines benefits from many research funds, such as National Institutes of Health in the US, Wellcome Trust in UK, German Research Foundation in Germany and many more. In this study an overview of the current open access programs and conditions of major journals in the field of medical informatics is presented. It was investigated whether there are suitable options and how they are shaped. Therefore all journals in Thomson Reuters Web of Science that were listed in the subject category "Medical Informatics" in 2014 were examined. An Internet research was conducted by investigating the journals' websites. It was reviewed whether journals offer an open access option with a subsequent check of conditions as for example the type of open access, the fees and the licensing. As a result all journals in the field of medical informatics that had an impact factor in 2014 offer an open access option. A predominantly consistent pricing range was determined with an average fee of 2.248 € and a median fee of 2.207 €. The height of a journals' open access fee did not correlate with the height of its Impact Factor. Hence, medical informatics journals have recognized the trend of open access publishing, though the vast majority of them are working with the hybrid method. Hybrid open access may however lead to problems in questions of double dipping and the often stipulated gold open access.

  8. Single K ATP channel opening in response to action potential firing in mouse dentate granule neurons.

    Science.gov (United States)

    Tanner, Geoffrey R; Lutas, Andrew; Martínez-François, Juan Ramón; Yellen, Gary

    2011-06-08

    ATP-sensitive potassium channels (K(ATP) channels) are important sensors of cellular metabolic state that link metabolism and excitability in neuroendocrine cells, but their role in nonglucosensing central neurons is less well understood. To examine a possible role for K(ATP) channels in modulating excitability in hippocampal circuits, we recorded the activity of single K(ATP) channels in cell-attached patches of granule cells in the mouse dentate gyrus during bursts of action potentials generated by antidromic stimulation of the mossy fibers. Ensemble averages of the open probability (p(open)) of single K(ATP) channels over repeated trials of stimulated spike activity showed a transient increase in p(open) in response to action potential firing. Channel currents were identified as K(ATP) channels through blockade with glibenclamide and by comparison with recordings from Kir6.2 knock-out mice. The transient elevation in K(ATP) p(open) may arise from submembrane ATP depletion by the Na(+)-K(+) ATPase, as the pump blocker strophanthidin reduced the magnitude of the elevation. Both the steady-state and stimulus-elevated p(open) of the recorded channels were higher in the presence of the ketone body R-β-hydroxybutyrate, consistent with earlier findings that ketone bodies can affect K(ATP) activity. Using perforated-patch recording, we also found that K(ATP) channels contribute to the slow afterhyperpolarization following an evoked burst of action potentials. We propose that activity-dependent opening of K(ATP) channels may help granule cells act as a seizure gate in the hippocampus and that ketone-body-mediated augmentation of the activity-dependent opening could in part explain the effect of the ketogenic diet in reducing epileptic seizures.

  9. Regularizing cubic open Neveu-Schwarz string field theory

    International Nuclear Information System (INIS)

    Berkovits, Nathan; Siegel, Warren

    2009-01-01

    After introducing non-minimal variables, the midpoint insertion of Y Y-bar in cubic open Neveu-Schwarz string field theory can be replaced with an operator N ρ depending on a constant parameter ρ. As in cubic open superstring field theory using the pure spinor formalism, the operator N ρ is invertible and is equal to 1 up to a BRST-trivial quantity. So unlike the linearized equation of motion Y Y-bar QV = 0 which requires truncation of the Hilbert space in order to imply QV = 0, the linearized equation N ρ QV = 0 directly implies QV = 0.

  10. Deformation of the cubic open string field theory

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Taejin, E-mail: taejin@kangwon.ac.kr

    2017-05-10

    We study a consistent deformation of the cubic open bosonic string theory in such a way that the non-planar world sheet diagrams of the perturbative string theory are mapped onto their equivalent planar diagrams of the light-cone string field theory with some length parameters fixed. An explicit evaluation of the cubic string vertex in the zero-slope limit yields the correct relationship between the string coupling constant and the Yang–Mills coupling constant. The deformed cubic open string field theory is shown to produce the non-Abelian Yang–Mills action in the zero-slope limit if it is defined on multiple D-branes. Applying the consistent deformation systematically to multi-string world sheet diagrams, we may be able to calculate scattering amplitudes with an arbitrary number of external open strings.

  11. Deformation of the cubic open string field theory

    Directory of Open Access Journals (Sweden)

    Taejin Lee

    2017-05-01

    Full Text Available We study a consistent deformation of the cubic open bosonic string theory in such a way that the non-planar world sheet diagrams of the perturbative string theory are mapped onto their equivalent planar diagrams of the light-cone string field theory with some length parameters fixed. An explicit evaluation of the cubic string vertex in the zero-slope limit yields the correct relationship between the string coupling constant and the Yang–Mills coupling constant. The deformed cubic open string field theory is shown to produce the non-Abelian Yang–Mills action in the zero-slope limit if it is defined on multiple D-branes. Applying the consistent deformation systematically to multi-string world sheet diagrams, we may be able to calculate scattering amplitudes with an arbitrary number of external open strings.

  12. Deformation of the cubic open string field theory

    International Nuclear Information System (INIS)

    Lee, Taejin

    2017-01-01

    We study a consistent deformation of the cubic open bosonic string theory in such a way that the non-planar world sheet diagrams of the perturbative string theory are mapped onto their equivalent planar diagrams of the light-cone string field theory with some length parameters fixed. An explicit evaluation of the cubic string vertex in the zero-slope limit yields the correct relationship between the string coupling constant and the Yang–Mills coupling constant. The deformed cubic open string field theory is shown to produce the non-Abelian Yang–Mills action in the zero-slope limit if it is defined on multiple D-branes. Applying the consistent deformation systematically to multi-string world sheet diagrams, we may be able to calculate scattering amplitudes with an arbitrary number of external open strings.

  13. Interacting open Wilson lines from noncommutative field theories

    International Nuclear Information System (INIS)

    Kiem, Youngjai; Lee, Sangmin; Rey, Soo-Jong; Sato, Haru-Tada

    2002-01-01

    In noncommutative field theories, it is known that the one-loop effective action describes the propagation of noninteracting open Wilson lines, obeying the flying dipole's relation. We show that the two-loop effective action describes the cubic interaction among 'closed string' states created by open Wilson line operators. Taking d-dimensional λ[Φ 3 ] * theory as the simplest setup, we compute the nonplanar contribution at a low-energy and large noncommutativity limit. We find that the contribution is expressible in a remarkably simple cubic interaction involving scalar open Wilson lines only and nothing else. We show that the interaction is purely geometrical and noncommutative in nature, depending only on the size of each open Wilson line

  14. Effects of nutmeg consumption on the open field locomotor activities ...

    African Journals Online (AJOL)

    ... was a steady significant difference (p < 0.05) in the behaviours of line crossing and walling. There was no much significant changes (P<0.05) in the behaviours of hinding, grooming and defeacation between the Treatments and Control groups of animals. Keywords: Nutmeg, Wistar rats, Open field, Locomotor activities ...

  15. Exact marginality in open string field theory. A general framework

    International Nuclear Information System (INIS)

    Kiermaier, M.

    2007-07-01

    We construct analytic solutions of open bosonic string field theory for any exactly marginal deformation in any boundary conformal field theory when properly renormalized operator products of the marginal operator are given. We explicitly provide such renormalized operator products for a class of marginal deformations which include the deformations of flat D-branes in flat backgrounds by constant massless modes of the gauge field and of the scalar fields on the D-branes, the cosine potential for a space-like coordinate, and the hyperbolic cosine potential for the time-like coordinate. In our construction we use integrated vertex operators, which are closely related to finite deformations in boundary conformal field theory, while previous analytic solutions were based on unintegrated vertex operators. We also introduce a modified star product to formulate string field theory around the deformed background. (orig.)

  16. On the electric field model for an open magnetosphere

    Science.gov (United States)

    Wang, Zhi; Ashour-Abdalla, Maha; Walker, Raymond J.

    1993-01-01

    We have developed a new canonical separator line type magnetospheric magnetic field and electric field model for use in magnetospheric calculations, we determine the magnetic and electric field by controlling the reconnection rate at the subsolar magnetopause. The model is applicable only for purely southward interplanetary magnetic field (IMF). We have obtained a more realistic magnetotail configuration by applying a stretch transformation to an axially symmetric field solution. We also discuss the Stern singularity in which there is an electric field singlarity in the canonical separate line models for B(sub y) not = to 0 by using a new technique that solves for the electric field along a field line directly instead of determining it by a potential mapping. The singularity not only causes an infinite electric field on the polar cap, but also causes the boundary conditions at plus infinity and minus infinity in the solar wind to contradict each other. This means that the canonical separator line models do not represent the open magnetosphere well, except for the case of purely southward IMF.

  17. Open Drug Discovery Toolkit (ODDT): a new open-source player in the drug discovery field.

    Science.gov (United States)

    Wójcikowski, Maciej; Zielenkiewicz, Piotr; Siedlecki, Pawel

    2015-01-01

    There has been huge progress in the open cheminformatics field in both methods and software development. Unfortunately, there has been little effort to unite those methods and software into one package. We here describe the Open Drug Discovery Toolkit (ODDT), which aims to fulfill the need for comprehensive and open source drug discovery software. The Open Drug Discovery Toolkit was developed as a free and open source tool for both computer aided drug discovery (CADD) developers and researchers. ODDT reimplements many state-of-the-art methods, such as machine learning scoring functions (RF-Score and NNScore) and wraps other external software to ease the process of developing CADD pipelines. ODDT is an out-of-the-box solution designed to be easily customizable and extensible. Therefore, users are strongly encouraged to extend it and develop new methods. We here present three use cases for ODDT in common tasks in computer-aided drug discovery. Open Drug Discovery Toolkit is released on a permissive 3-clause BSD license for both academic and industrial use. ODDT's source code, additional examples and documentation are available on GitHub (https://github.com/oddt/oddt).

  18. Analytic study of nonperturbative solutions in open string field theory

    International Nuclear Information System (INIS)

    Bars, I.; Kishimoto, I.; Matsuo, Y.

    2003-01-01

    We propose an analytic framework to study the nonperturbative solutions of Witten's open string field theory. The method is based on the Moyal star formulation where the kinetic term can be split into two parts. The first one describes the spectrum of two identical half strings which are independent from each other. The second one, which we call midpoint correction, shifts the half string spectrum to that of the standard open string. We show that the nonlinear equation of motion of string field theory is exactly solvable at zeroth order in the midpoint correction. An infinite number of solutions are classified in terms of projection operators. Among them, there exists only one stable solution which is identical to the standard butterfly state. We include the effect of the midpoint correction around each exact zeroth order solution as a perturbation expansion which can be formally summed to the complete exact solution

  19. On multibrane solutions in open string field theory

    Czech Academy of Sciences Publication Activity Database

    Murata, Masaki; Schnabl, Martin

    2011-01-01

    Roč. 2011, č. 188 (2011), s. 50-55 ISSN 0375-9687. [International Conference on String Field Theory and Related Aspects (SFT2010). Kyoto, 18.10.2010-22.10.2010] Grant - others:EUROHORC and ESF(XE) EYI/07/E010 Institutional research plan: CEZ:AV0Z10100502 Keywords : string field theory * D-branes * open strings Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 1.063, year: 2011 http://ptp.ipap.jp/link?PTPS/188/50/

  20. Localization of effective actions in open superstring field theory

    Science.gov (United States)

    Maccaferri, Carlo; Merlano, Alberto

    2018-03-01

    We consider the construction of the algebraic part of D-branes tree-level effective action from Berkovits open superstring field theory. Applying this construction to the quartic potential of massless fields carrying a specific worldsheet charge, we show that the full contribution to the potential localizes at the boundary of moduli space, reducing to elementary two-point functions. As examples of this general mechanism, we show how the Yang-Mills quartic potential and the instanton effective action of a Dp/D( p - 4) system are reproduced.

  1. Counterstreaming solar wind halo electron events on open field lines?

    Science.gov (United States)

    Gosling, J. T.; Mccomas, D. J.; Phillips, J. L.

    1992-01-01

    Counterstreaming solar wind halo electron events have been identified as a common 1 AU signature of coronal mass ejection events, and have generally been interpreted as indicative of closed magnetic field topologies, i.e., magnetic loops or flux ropes rooted at both ends in the Sun, or detached plasmoids. In this paper we examine the possibility that these events may instead occur preferentially on open field lines, and that counterstreaming results from reflection or injection behind interplanetary shocks or from mirroring from regions of compressed magnetic field farther out in the heliosphere. We conclude that neither of these suggested sources of counterstreaming electron beams is viable and that the best interpretation of observed counterstreaming electron events in the solar wind remains that of passage of closed field structures.

  2. Open string Regge trajectory and its field theory limit

    International Nuclear Information System (INIS)

    Rojas, Francisco; Thorn, Charles B.

    2011-01-01

    We study the properties of the leading Regge trajectory in open string theory including the open string planar one-loop corrections. With SU(N) Chan-Paton factors, the sum over planar open string multiloop diagrams describes the 't Hooft limit N→∞ with Ng s 2 fixed. Our motivation is to improve the understanding of open string theory at finite α ' as a model of gauge field theories. SU(N) gauge theories in D space-time dimensions are described by requiring open strings to end on a stack of N Dp-branes of space-time dimension D=p+1. The large N leading trajectory α(t)=1+α ' t+Σ(t) can be extracted, through order g 2 , from the s→-∞ limit, at fixed t, of the four open string tree and planar loop diagrams. We analyze the t→0 behavior with the result that Σ(t)∼-Cg 2 (-α ' t) (D-4)/2 /(D-4). This result precisely tracks the 1-loop Reggeized gluon of gauge theory in D>4 space-time dimensions. In particular, for D→4 it reproduces the known infrared divergences of gauge theory in 4 dimensions with a Regge trajectory behaving as -ln(-α ' t). We also study Σ(t) in the limit t→-∞ and show that, when D ' t/(ln(-α ' t)) γ , where γ>0 depends on D and the number of massless scalars. Thus, as long as 4 ' t arbitrarily large. Finally we present the results of numerical calculations of Σ(t) for all negative t.

  3. Temporal stability of novelty exploration in mice exposed to different open field tests.

    Science.gov (United States)

    Kalueff, Allan V; Keisala, Tiina; Minasyan, Anna; Kuuslahti, Marianne; Tuohimaa, Pentti

    2006-03-01

    We investigated behavioural activity and temporal distribution (patterning) of mouse exploration in different open field (OF) arenas. Mice of 129S1 (S1) strain were subjected in parallel to three different OF arenas (Experiment 1), two different OF arenas in two trials (Experiment 2) or two trials of the same OF test (Experiment 3). Overall, mice demonstrated a high degree of similarity in the temporal profile of novelty-induced horizontal and vertical exploration (regardless of the size, colour and shape of the OF), which remained stable in subsequent OF exposures. In Experiments 4 and 5, we tested F1 hybrid mice (BALB/c-S1; NMRI-S1), and Vitamin D receptor knockout mice (generated on S1 genetic background), again showing strikingly similar temporal patterns of their OF exploration, despite marked behavioural strain differences in anxiety and activity. These results suggest that mice are characterised by stability of temporal organization of their exploration in different OF novelty situations.

  4. Field theory of interacting open superstrings of fermionic ghost representation

    International Nuclear Information System (INIS)

    Aref'eva, I.Ya.; Medvedev, P.V.

    1987-01-01

    Field theory of interacting open superstring in fermionic ghost representation based on anticommuting and commuting ghosts corresponding respectively to world sheet bosonic x μ and fermionic φ μ coordinates is presented. The author have to revise once more the field theory of the free Ramond (R) string and starting from general algebraic point of view they obtain that the number of degrees of freedom in the R and NS (Neveu-Schwartz) sectors equalise themselves permitting to construct a supersymmetric operator. It is proposed to solve a specific equation guaranteeing superinvariance in order to find the R-R-NS and NS-R-R vertices in the term of the NS-NS-NS vertex

  5. How to create successful Open Hardware projects — About White Rabbits and open fields

    International Nuclear Information System (INIS)

    Bij, E van der; Arruat, M; Cattin, M; Daniluk, G; Cobas, J D Gonzalez; Gousiou, E; Lewis, J; Lipinski, M M; Serrano, J; Stana, T; Voumard, N; Wlostowski, T

    2013-01-01

    CERN's accelerator control group has embraced ''Open Hardware'' (OH) to facilitate peer review, avoid vendor lock-in and make support tasks scalable. A web-based tool for easing collaborative work was set up and the CERN OH Licence was created. New ADC, TDC, fine delay and carrier cards based on VITA and PCI-SIG standards were designed and drivers for Linux were written. Often industry was paid for developments, while quality and documentation was controlled by CERN. An innovative timing network was also developed with the OH paradigm. Industry now sells and supports these designs that find their way into new fields

  6. How to create successful Open Hardware projects - About White Rabbits and open fields

    CERN Document Server

    van der Bij, E; Lewis, J; Stana, T; Wlostowski, T; Gousiou, E; Serrano, J; Arruat, M; Lipinski, M M; Daniluk, G; Voumard, N; Cattin, M

    2013-01-01

    CERN's accelerator control group has embraced "Open Hardware" (OH) to facilitate peer review, avoid vendor lock-in and make support tasks scalable. A web-based tool for easing collaborative work was set up and the CERN OH Licence was created. New ADC, TDC, fine delay and carrier cards based on VITA and PCI-SIG standards were designed and drivers for Linux were written. Often industry was paid for developments, while quality and documentation was controlled by CERN. An innovative timing network was also developed with the OH paradigm. Industry now sells and supports these designs that find their way into new fields.

  7. Use of the Open Field Maze to measure locomotor and anxiety-like behavior in mice.

    Science.gov (United States)

    Seibenhener, Michael L; Wooten, Michael C

    2015-02-06

    Animal models have proven to be invaluable to researchers trying to answer questions regarding the mechanisms of behavior. The Open Field Maze is one of the most commonly used platforms to measure behaviors in animal models. It is a fast and relatively easy test that provides a variety of behavioral information ranging from general ambulatory ability to data regarding the emotionality of the subject animal. As it relates to rodent models, the procedure allows the study of different strains of mice or rats both laboratory bred and wild-captured. The technique also readily lends itself to the investigation of different pharmacological compounds for anxiolytic or anxiogenic effects. Here, a protocol for use of the open field maze to describe mouse behaviors is detailed and a simple analysis of general locomotor ability and anxiety-related emotional behaviors between two strains of C57BL/6 mice is performed. Briefly, using the described protocol we show Wild Type mice exhibited significantly less anxiety related behaviors than did age-matched Knock Out mice while both strains exhibited similar ambulatory ability.

  8. Aged Tg2576 mice are impaired on social memory and open field habituation tests.

    Science.gov (United States)

    Deacon, R M J; Koros, E; Bornemann, K D; Rawlins, J N P

    2009-02-11

    In a previous publication [Deacon RMJ, Cholerton LL, Talbot K, Nair-Roberts RG, Sanderson DJ, Romberg C, et al. Age-dependent and -independent behavioral deficits in Tg2576 mice. Behav Brain Res 2008;189:126-38] we found that very few cognitive tests were suitable for demonstrating deficits in Tg2576 mice, an amyloid over-expression model of Alzheimer's disease, even at 23 months of age. However, in a retrospective analysis of a separate project on these mice, tests of social memory and open field habituation revealed large cognitive impairments. Controls showed good open field habituation, but Tg2576 mice were hyperactive and failed to habituate. In the test of social memory for a juvenile mouse, controls showed considerably less social investigation on the second meeting, indicating memory of the juvenile, whereas Tg2576 mice did not show this decrement.As a control for olfactory sensitivity, on which social memory relies, the ability to find a food pellet hidden under wood chip bedding was assessed. Tg2576 mice found the pellet as quickly as controls. As this test requires digging ability, this was independently assessed in tests of burrowing and directly observed digging. In line with previous results and the hippocampal dysfunction characteristic of aged Tg2576 mice, they both burrowed and dug less than controls.

  9. Keldysh field theory for driven open quantum systems.

    Science.gov (United States)

    Sieberer, L M; Buchhold, M; Diehl, S

    2016-09-01

    Recent experimental developments in diverse areas-ranging from cold atomic gases to light-driven semiconductors to microcavity arrays-move systems into the focus which are located on the interface of quantum optics, many-body physics and statistical mechanics. They share in common that coherent and driven-dissipative quantum dynamics occur on an equal footing, creating genuine non-equilibrium scenarios without immediate counterpart in equilibrium condensed matter physics. This concerns both their non-thermal stationary states and their many-body time evolution. It is a challenge to theory to identify novel instances of universal emergent macroscopic phenomena, which are tied unambiguously and in an observable way to the microscopic drive conditions. In this review, we discuss some recent results in this direction. Moreover, we provide a systematic introduction to the open system Keldysh functional integral approach, which is the proper technical tool to accomplish a merger of quantum optics and many-body physics, and leverages the power of modern quantum field theory to driven open quantum systems.

  10. Linear b-gauges for open string fields

    International Nuclear Information System (INIS)

    Kiermaier, Michael; Zwiebach, Barton; Sen, Ashoke

    2008-01-01

    Motivated by Schnabl's gauge choice, we explore open string perturbation theory in gauges where a linear combination of antighost oscillators annihilates the string field. We find that in these linear b-gauges different gauge conditions are needed at different ghost numbers. We derive the full propagator and prove the formal properties which guarantee that the Feynman diagrams reproduce the correct on-shell amplitudes. We find that these properties can fail due to the need to regularize the propagator, and identify a large class of linear b-gauges for which they hold rigorously. In these gauges the propagator has a non-anomalous Schwinger representation and builds Riemann surfaces by adding strip-like domains. Projector-based gauges, like Schnabl's, are not in this class of gauges but we construct a family of regular linear b-gauges which interpolate between Siegel gauge and Schnabl gauge

  11. Precipitation-generated oscillations in open cellular cloud fields.

    Science.gov (United States)

    Feingold, Graham; Koren, Ilan; Wang, Hailong; Xue, Huiwen; Brewer, Wm Alan

    2010-08-12

    Cloud fields adopt many different patterns that can have a profound effect on the amount of sunlight reflected back to space, with important implications for the Earth's climate. These cloud patterns can be observed in satellite images of the Earth and often exhibit distinct cell-like structures associated with organized convection at scales of tens of kilometres. Recent evidence has shown that atmospheric aerosol particles-through their influence on precipitation formation-help to determine whether cloud fields take on closed (more reflective) or open (less reflective) cellular patterns. The physical mechanisms controlling the formation and evolution of these cells, however, are still poorly understood, limiting our ability to simulate realistically the effects of clouds on global reflectance. Here we use satellite imagery and numerical models to show how precipitating clouds produce an open cellular cloud pattern that oscillates between different, weakly stable states. The oscillations are a result of precipitation causing downward motion and outflow from clouds that were previously positively buoyant. The evaporating precipitation drives air down to the Earth's surface, where it diverges and collides with the outflows of neighbouring precipitating cells. These colliding outflows form surface convergence zones and new cloud formation. In turn, the newly formed clouds produce precipitation and new colliding outflow patterns that are displaced from the previous ones. As successive cycles of this kind unfold, convergence zones alternate with divergence zones and new cloud patterns emerge to replace old ones. The result is an oscillating, self-organized system with a characteristic cell size and precipitation frequency.

  12. Open and Closed String field theory interpreted in classical Algebraic Topology

    OpenAIRE

    Sullivan, Dennis

    2003-01-01

    There is an interpretation of open string field theory in algebraic topology. An interpretation of closed string field theory can be deduced from this open string theory to obtain as well the interpretation of open and closed string field theory combined.

  13. Identification of QLTs involved in open-field behavior in young and ad laying hens

    NARCIS (Netherlands)

    Buitenhuis, A.J.; Rodenburg, T.B.; Siwek, M.Z.; Cornelissen, S.J.B.; Nieuwland, M.G.B.; Crooijmans, R.P.M.A.; Groenen, M.A.M.; Koene, P.; Bovenhuis, H.; Poel, van der J.J.

    2004-01-01

    Line differences for open-field behavior in chickens have been observed, and it has been shown that this behavior has a genetic component. The aim of this study was to detect quantitative trait loci (QTL) involved in open-field behavior. For this purpose, open-field behavior was studied at 5 and 29

  14. Female mucopolysaccharidosis IIIA mice exhibit hyperactivity and a reduced sense of danger in the open field test.

    Directory of Open Access Journals (Sweden)

    Alex Langford-Smith

    Full Text Available Reliable behavioural tests in animal models of neurodegenerative diseases allow us to study the natural history of disease and evaluate the efficacy of novel therapies. Mucopolysaccharidosis IIIA (MPS IIIA or Sanfilippo A, is a severe, neurodegenerative lysosomal storage disorder caused by a deficiency in the heparan sulphate catabolising enzyme, sulfamidase. Undegraded heparan sulphate accumulates, resulting in lysosomal enlargement and cellular dysfunction. Patients suffer a progressive loss of motor and cognitive function with severe behavioural manifestations and premature death. There is currently no treatment. A spontaneously occurring mouse model of the disease has been described, that has approximately 3% of normal enzyme activity levels. Behavioural phenotyping of the MPS IIIA mouse has been previously reported, but the results are conflicting and variable, even after full backcrossing to the C57BL/6 background. Therefore we have independently backcrossed the MPS IIIA model onto the C57BL/6J background and evaluated the behaviour of male and female MPS IIIA mice at 4, 6 and 8 months of age using the open field test, elevated plus maze, inverted screen and horizontal bar crossing at the same circadian time point. Using a 60 minute open field, we have demonstrated that female MPS IIIA mice are hyperactive, have a longer path length, display rapid exploratory behaviour and spend less time immobile than WT mice. Female MPS IIIA mice also display a reduced sense of danger and spend more time in the centre of the open field. There were no significant differences found between male WT and MPS IIIA mice and no differences in neuromuscular strength were seen with either sex. The altered natural history of behaviour that we observe in the MPS IIIA mouse will allow more accurate evaluation of novel therapeutics for MPS IIIA and potentially other neurodegenerative disorders.

  15. Female mucopolysaccharidosis IIIA mice exhibit hyperactivity and a reduced sense of danger in the open field test.

    Science.gov (United States)

    Langford-Smith, Alex; Langford-Smith, Kia J; Jones, Simon A; Wynn, Robert F; Wraith, J E; Wilkinson, Fiona L; Bigger, Brian W

    2011-01-01

    Reliable behavioural tests in animal models of neurodegenerative diseases allow us to study the natural history of disease and evaluate the efficacy of novel therapies. Mucopolysaccharidosis IIIA (MPS IIIA or Sanfilippo A), is a severe, neurodegenerative lysosomal storage disorder caused by a deficiency in the heparan sulphate catabolising enzyme, sulfamidase. Undegraded heparan sulphate accumulates, resulting in lysosomal enlargement and cellular dysfunction. Patients suffer a progressive loss of motor and cognitive function with severe behavioural manifestations and premature death. There is currently no treatment. A spontaneously occurring mouse model of the disease has been described, that has approximately 3% of normal enzyme activity levels. Behavioural phenotyping of the MPS IIIA mouse has been previously reported, but the results are conflicting and variable, even after full backcrossing to the C57BL/6 background. Therefore we have independently backcrossed the MPS IIIA model onto the C57BL/6J background and evaluated the behaviour of male and female MPS IIIA mice at 4, 6 and 8 months of age using the open field test, elevated plus maze, inverted screen and horizontal bar crossing at the same circadian time point. Using a 60 minute open field, we have demonstrated that female MPS IIIA mice are hyperactive, have a longer path length, display rapid exploratory behaviour and spend less time immobile than WT mice. Female MPS IIIA mice also display a reduced sense of danger and spend more time in the centre of the open field. There were no significant differences found between male WT and MPS IIIA mice and no differences in neuromuscular strength were seen with either sex. The altered natural history of behaviour that we observe in the MPS IIIA mouse will allow more accurate evaluation of novel therapeutics for MPS IIIA and potentially other neurodegenerative disorders.

  16. THE TOPOLOGICAL CHANGES OF SOLAR CORONAL MAGNETIC FIELDS. II. THE RECLOSING OF AN OPENED FIELD

    International Nuclear Information System (INIS)

    Low, B. C.; Janse, A. M.

    2009-01-01

    This is a study of the spontaneous formation of current sheets responding to the closing of an opened magnetic field by resistive reconnection in an electrically, highly conducting atmosphere outside a unit sphere. Pairs of initial-final equilibrium states are calculated explicitly, taking the field to be composed of three systems of untwisted flux in both states. In the initial state, two of the three flux systems are closed potential fields whereas the third system contains an equilibrium current sheet that keeps the potential fields on its two sides globally open. The final state is an everywhere potential field, with all three flux systems closed, produced by the resistive dissipation of the current sheet in the initial state. The unit sphere is taken to be a rigid, perfectly conducting wall during reconnection, so that the normal flux distribution is unchanged on the unit sphere. Field solutions subject to this unchanging boundary condition are obtained with and without the assumption of axisymmetry. The mathematical model has been designed to show that the topological changes produced by the current-sheet dissipation are simple under axisymmetry but radically different in the absence of axisymmetry, a fundamental point established in the first paper of this series. In the general case, the topological changes imply that other current sheets must have formed. Some of these current sheets form on the separatrix flux surfaces of the multipolar field. Others form throughout the closed-flux systems induced by volumetric changes. The opening and reclosing of magnetic fields during a solar coronal mass ejection may produce a multitude of current sheets not previously anticipated in the current understanding of this phenomenon. Basic to this study is a general topological property of magnetic flux tubes treated separately in the Appendix.

  17. Inexpensive Open-Source Data Logging in the Field

    Science.gov (United States)

    Wickert, A. D.

    2013-12-01

    I present a general-purpose open-source field-capable data logger, which provides a mechanism to develop dense networks of inexpensive environmental sensors. This data logger was developed as a low-power variant of the Arduino open-source development system, and is named the ALog ("Arduino Logger") BottleLogger (it is slim enough to fit inside a Nalgene water bottle) version 1.0. It features an integrated high-precision real-time clock, SD card slot for high-volume data storage, and integrated power switching. The ALog can interface with sensors via six analog/digital pins, two digital pins, and one digital interrupt pin that can read event-based inputs, such as those from a tipping-bucket rain gauge. We have successfully tested the ALog BottleLogger with ultrasonic rangefinders (for water stage and snow accumulation and melt), temperature sensors, tipping-bucket rain gauges, soil moisture and water potential sensors, resistance-based tools to measure frost heave, and cameras that it triggers based on events. The source code for the ALog, including functions to interface with a a range of commercially-available sensors, is provided as an Arduino C++ library with example implementations. All schematics, circuit board layouts, and source code files are open-source and freely available under GNU GPL v3.0 and Creative Commons Attribution-ShareAlike 3.0 Unported licenses. Through this work, we hope to foster a community-driven movement to collect field environmental data on a budget that permits citizen-scientists and researchers from low-income countries to collect the same high-quality data as researchers in wealthy countries. These data can provide information about global change to managers, governments, scientists, and interested citizens worldwide. Watertight box with ALog BottleLogger data logger on the left and battery pack with 3 D cells on the right. Data can be collected for 3-5 years on one set of batteries.

  18. Neuroglobin overexpression inhibits oxygen-glucose deprivation-induced mitochondrial permeability transition pore opening in primary cultured mouse cortical neurons.

    Science.gov (United States)

    Yu, Zhanyang; Liu, Ning; Li, Yadan; Xu, Jianfeng; Wang, Xiaoying

    2013-08-01

    Neuroglobin (Ngb) is an endogenous neuroprotective molecule against hypoxic/ischemic brain injury, but the underlying mechanisms remain largely undefined. Our recent study revealed that Ngb can bind to voltage-dependent anion channel (VDAC), a regulator of mitochondria permeability transition (MPT). In this study we examined the role of Ngb in MPT pore (mPTP) opening following oxygen-glucose deprivation (OGD) in primary cultured mouse cortical neurons. Co-immunoprecipitation (Co-IP) and immunocytochemistry showed that the binding between Ngb and VDAC was increased after OGD compared to normoxia, indicating the OGD-enhanced Ngb-VDAC interaction. Ngb overexpression protected primary mouse cortical neurons from OGD-induced neuronal death, to an extent comparable to mPTP opening inhibitor, cyclosporine A (CsA) pretreatment. We further measured the role of Ngb in OGD-induced mPTP opening using Ngb overexpression and knockdown approaches in primary cultured neurons, and recombinant Ngb exposure to isolated mitochondria. Same as CsA pretreatment, Ngb overexpression significantly reduced OGD-induced mPTP opening markers including mitochondria swelling, mitochondrial NAD(+) release, and cytochrome c (Cyt c) release in primary cultured neurons. Recombinant Ngb incubation significantly reduced OGD-induced NAD(+) release and Cyt c release from isolated mitochondria. In contrast, Ngb knockdown significantly increased OGD-induced neuron death, and increased OGD-induced mitochondrial NAD(+) release and Cyt c release as well, and these outcomes could be rescued by CsA pretreatment. In summary, our results demonstrated that Ngb overexpression can inhibit OGD-induced mPTP opening in primary cultured mouse cortical neurons, which may be one of the molecular mechanisms of Ngb's neuroprotection. Copyright © 2013 Elsevier Inc. All rights reserved.

  19. Variable stars in the field of open cluster NGC 2126

    International Nuclear Information System (INIS)

    Liu Shunfang; Wu Zhenyu; Zhang Xiaobin; Wu Jianghua; Ma Jun; Jiang Zhaoji; Chen Jiansheng; Zhou Xu

    2009-01-01

    We report the results of a time-series CCD photometric survey of variable stars in the field of open cluster NGC 2126. In about a one square degree field covering the cluster, a total of 21 variable candidates are detected during this survey, of which 16 are newly found. The periods, classifications and spectral types of 14 newly discovered variables are discussed, which consist of six eclipsing binary systems, three pulsating variable stars, three long period variables, one RS CVn star, and one W UMa or δ Scuti star. In addition, there are two variable candidates, the properties of which cannot be determined. By a method based on fitting observed spectral energy distributions of stars with theoretical ones, the membership probabilities and the fundamental parameters of this cluster are determined. As a result, five variables are probably members of NGC 2126. The fundamental parameters of this cluster are determined as: metallicity to be 0.008 Z o-dot , age log(t) = 8.95, distance modulus (m - M) 0 = 10.34 and reddening value E (B - V) = 0.55 mag.

  20. Status of open access in the biomedical field in 2005.

    Science.gov (United States)

    Matsubayashi, Mamiko; Kurata, Keiko; Sakai, Yukiko; Morioka, Tomoko; Kato, Shinya; Mine, Shinji; Ueda, Shuichi

    2009-01-01

    This study was designed to document the state of open access (OA) in the biomedical field in 2005. PubMed was used to collect bibliographic data on target articles published in 2005. PubMed, Google Scholar, Google, and OAIster were then used to establish the availability of free full text online for these publications. Articles were analyzed by type of OA, country, type of article, impact factor, publisher, and publishing model to provide insight into the current state of OA. Twenty-seven percent of all the articles were accessible as OA articles. More than 70% of the OA articles were provided through journal websites. Mid-rank commercial publishers often provided OA articles in OA journals, while society publishers tended to provide OA articles in the context of a traditional subscription model. The rate of OA articles available from the websites of individual authors or in institutional repositories was quite low. In 2005, OA in the biomedical field was achieved under an umbrella of existing scholarly communication systems. Typically, OA articles were published as part of subscription journals published by scholarly societies. OA journals published by BioMed Central contributed to a small portion of all OA articles.

  1. Prepartum and postpartum open-field behavior and maternal responsiveness in mice bidirectionally selected for open-field thigmotaxis.

    Science.gov (United States)

    Leppänen, Pia K; Ravaja, Niklas; Ewalds-Kvist, S Béatrice M

    2008-01-01

    The authors examined pre- and postpartum open-field (OF) behavior and maternal responsiveness in mice that they bidirectionally selected for OF thigmotaxis. The authors tested 40 female mice under 3 conditions: prepartum OF, postpartum OF, and a pup retrieval test. In both OF conditions, the high OF thigmotaxis (HOFT) mice were more thigmotactic but explored and reared less than the low OF thigmotaxis (LOFT) mice, indicating that the HOFT mice were more emotional. In the postpartum condition, the HOFT mothers also defecated more and ambulated less than the LOFT mothers. The increase in grooming after parturition was more conspicuous among the LOFT mothers than among the HOFT mothers. The LOFT mothers were also more attracted to their pups in the OF, but the retrieval test did not show any substantial line differences. The results suggested that the line difference in emotionality was more pronounced during lactation than during pregnancy, although parturition exerted no effect on thigmotaxis.

  2. Effect of anti-vertigo granule on the opening number and blood flow of mouse ear capillary network

    Science.gov (United States)

    Li, Chongxian; Liu, Xiaobin; Li, Jun; Hao, Shaojun; Wang, Xidong; Li, Wenjun; Zhang, Zhengchen

    2018-04-01

    To observe the effects of anti-glare particles on the open number and blood flow in the auricle of mice with microcirculation disturbance model. Sixty mice, half male and half female, were randomly divided into 6 groups. The mice were given Kangxuan granule suspension, serum brain granule suspension and normal saline of the same volume, respectively, once a day. The mice were anesthetized by intraperitoneal injection of chloral hydrate at 1 hour after the last administration. The mouse was fixed on the observation platform and the auricle was placed on the transmission stage. BZ-2000 microcirculation microscope and microcirculation analysis system were used to observe the changes of blood velocity and capillary opening volume in auricle of mice before administration. The changes of blood velocity and capillaries opening volume of mouse auricle were observed 2 min after epinephrine injection into tail vein of mice. Bear fruit: Compared with those before epinephrine, the opening number of capillary reticulum of auricle in large dose Kangxuan granule group was significantly decreased (Pgroup and middle group. In the small dose Kangxuan granule group, the opening number of capillary network of auricle decreased significantly (Pgroup, the large dose Kangxuan granule group could significantly increase the opening number of the auricle capillary network in mice (Pgroup could significantly increase the opening number of auricle capillary reticulum in mice (Pgroup by Ridit test. Both Kangxuan granule group and Yangxuannao granule group could significantly improve the auricle hair of mice with microcirculation disorder. The blood flow in fine blood vessels (Pblood flow in mice with microcirculation disorder.

  3. Open magnetic fields and the solar cycle. Pt. 1

    International Nuclear Information System (INIS)

    Levine, R.H.

    1982-01-01

    Models of open magnetic structures on the Sun are presented for periods near solar minimum (CR 1626-1634) and near solar maximum (CR 1668-1678). Together with previous models of open magnetic structures during the declining phase (CR 1601-1611) these calculations provide clues to the relations between open structures, coronal holes, and active regions at different times of the solar cycle. Near solar minimum the close relation between active regions and open structures does not exist. It is suggested that near solar minimum the systematic emergence of new flux with the proper polarity imbalance to maintain open magnetic structures may occur primarily at very small spatial scales. Near solar maximum the role of active regions in maintaining open structures and coronal holes is strong, with large active regions emerging in the proper location and orientation to maintain open structures longer than typical active region lifetimes. Although the use of He I 10830 A spectroheliograms as a coronal hole indicator is shown to be subject to significant ambiguity, the agreement between calculated open structures and coronal holes determined from He I 10830 A spectroheliograms is very good. The rotation properties of calculated open structures near solar maximum strongly suggest two classes of features: one that rotates differentially similar to sunspots and active regions and a separate class that rotates more rigidly, as was the case for single large coronal holes during Skylab. (orig.)

  4. A covariant open bosonic string field theory including the endpoint and middlepoint interaction

    International Nuclear Information System (INIS)

    Liu, B.G.; Northwest Univ., Xian; Chen, Y.X.

    1988-01-01

    Extending the usual endpoint and midpoint interactions, we introduce numerous kinds of interactions, labelled by a parameter λ and obtain a non-commutative and associative string field algebra by adding up all interactions. With this algebra we develop a covariant open bosonic string field theory, which reduces to Witten's open bosonic string field theory under a special string length choice. (orig.)

  5. Standardized UXO Technology Demonstration Site. Open Field Scoring Record Number 154

    National Research Council Canada - National Science Library

    Overbay, Larry

    2004-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  6. Standardized UXO Technology Demonstration Site, Open Field Scoring Record Number 379

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ... (UXO) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. Scoring Records have been coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  7. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 354

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Archiable, Robert; McClung, Christina

    2005-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  8. Standardized UXO Technology Demonstration Site Open Field Scoring Record No. 311

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Boutin, Matthew; Fling, Rick; McClung, Christina; Robitaille, George

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  9. Standardized UXO Technology Demonstration Site Open Field Scoring Recording Number 231 (Human Factors Applications, Inc.)

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbuy and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  10. Standardized UXO Technology Demonstration Site, Open Field Scoring Record Number 426

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Boutin, Matthew; Archiable, Robert; Fling, Rick; McClung, Christina; Robitaille, George

    2005-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site Open Field. Scoring Records have been coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  11. Standardized UXO Technology Demonstration Site, Open Field Scoring Record Number 657

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. Scoring Records have been coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  12. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 129

    National Research Council Canada - National Science Library

    Overbay, Larry

    2004-01-01

    ...) utilizing the APO Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  13. Standardized UXO Technology Demonstration Site, Open Field Scoring Record Number 229

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Boutin, Matthew; Fling, Rick; McClung, Christina; Robitaille, George

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  14. Standardized UXO Technology Demonstration Site, Open Field Scoring Record Number 411

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  15. Standardized UXO Technology Demonstration Site, Open Field Scoring Record No. 897

    National Research Council Canada - National Science Library

    Burch, William; Fling, Rick; McClung, Christina

    2008-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. This Scoring Record was coordinated by William Burch and the Standardized UXO Technology Demonstration Site Scoring Committee...

  16. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 673 (Naval Research Laboratories)

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing the APG standardized UXO Technology Demonstration Site Open Field. Scoring Records have been coordinate by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  17. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 169

    National Research Council Canada - National Science Library

    Overbay, Larry; Archiable, Robert; McClung, Christina; Robitaille, George

    2005-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  18. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 492 (Shaw Environmental, Inc.)

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. Scoring Records have been coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  19. Standardized UXO Technology Demonstration Site Open Field Scoring Record No. 442

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Boutin, Matthew; Archiable, Robert; Fling, Rick; McClung, Christina; Robitaille, George

    2005-01-01

    ...) unitizing the YPG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  20. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 201

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Fling, Rick; Robitaille, George

    2004-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  1. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 668 (NAEVA Geophysics, Inc.)

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing they PG Standardized UXO Technology Demonstration Site Open Field. Scoring Records have been coordinate by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  2. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 165

    National Research Council Canada - National Science Library

    Overbay, Larry

    2004-01-01

    ...) utilizing the APO Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  3. Standardized UXO Technology Demonstration Site, Open Field Scoring Record Number 638

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Robitaille, George; Boutin, Matthew; Archiable, Robert; McClung, Christina

    2005-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  4. Standardized UXO Technology Demonstration Site Open Field Scoring Record No. 857

    National Research Council Canada - National Science Library

    Fling, Rick; McClung, Christina; Banta, Matthew; Burch, William; McDonnell, Patrick

    2007-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. This Scoring Record was coordinated by Dennis Teefy and the Standardized UXO Technology Demonstration Site Scoring Committee...

  5. Open BRST algebras, ghost unification and string field theory

    NARCIS (Netherlands)

    Baulieu, Laurent; Bergshoeff, Eric; Sezgin, Ergin

    1988-01-01

    Geometrical aspects of the BRST quantization of charged antisymmetric tensor fields and string fields are studied within the framework of the Batalin and Vilkovisky method. In both cases, candidate anomalies which obey the Wess-Zumino consistency conditions are given.

  6. Structure and magnetic field of periodic permanent magnetic focusing system with open magnetic rings

    International Nuclear Information System (INIS)

    Peng Long; Li Lezhong; Yang Dingyu; Zhu Xinghua; Li Yuanxun

    2011-01-01

    The magnetic field along the central axis for an axially magnetized permanent magnetic ring was investigated by analytical and finite element methods. For open magnetic rings, both calculated and measured results show that the existence of the radial magnetic field creates a remarkable cosine distribution field along the central axis. A new structure of periodic permanent magnet focusing system with open magnetic rings is proposed. The structure provides a satisfactory magnetic field with a stable peak value of 120 mT for a traveling wave tube system. - Research highlights: → For open magnetic rings, both calculated and measured results show that the existence of the radial magnetic field creates a remarkable cosine distribution field along the central axis. → A new structure of periodic permanent magnet (PPM) focusing system with open magnetic rings is proposed. → The new PPM focusing system with open magnetic rings meets the requirements for TWT system.

  7. A proposal for an effective interacting field theory of open and closed strings

    International Nuclear Information System (INIS)

    Baulieu, L.; Grossman, B.

    1987-01-01

    We propose the use of the reggeon-pomeron vertex to obtain an effective field theory for open and closed strings. We suggest that closed string fields are necessary in order to go off-shell in an open string field theory. We then find that the closed string fields satisfy the Virasoro constraints (including equal number of left and right movers) in an appropriate choice of gauge. (orig.)

  8. Management of whitefly-transmitted viruses in open-field production systems

    Science.gov (United States)

    Whiteflies are a key pest of crops in open field production throughout the tropics and subtropics. This is due in large part to the long and diverse list of devastating plant viruses transmitted by these vectors. Open field production provides many challenges to manage these viruses and in many case...

  9. Energy momentum tensor and marginal deformations in open string field theory

    International Nuclear Information System (INIS)

    Sen, Ashoke

    2004-01-01

    Marginal boundary deformations in a two dimensional conformal field theory correspond to a family of classical solutions of the equations of motion of open string field theory. In this paper we develop a systematic method for relating the parameter labelling the marginal boundary deformation in the conformal field theory to the parameter labelling the classical solution in open string field theory. This is done by first constructing the energy-momentum tensor associated with the classical solution in open string field theory using Noether method, and then comparing this to the answer obtained in the conformal field theory by analysing the boundary state. We also use this method to demonstrate that in open string field theory the tachyon lump solution on a circle of radius larger than one has vanishing pressure along the circle direction, as is expected for a co-dimension one D-brane. (author)

  10. Open membranes in a constant C-field background and noncommutative boundary strings

    International Nuclear Information System (INIS)

    Kawamoto, Shoichi; Sasakura, Naoki

    2000-01-01

    We investigate the dynamics of open membrane boundaries in a constant C-field background. We follow the analysis for open strings in a B-field background, and take some approximations. We find that open membrane boundaries do show noncommutativity in this case by explicit calculations. Membrane boundaries are one dimensional strings, so we face a new type of noncommutativity, that is, noncommutative strings. (author)

  11. Open BRST algebras, ghost unification and string field theory

    International Nuclear Information System (INIS)

    Baulieu, L.; Bergshoeff, E.; Sezgin, E.

    1988-01-01

    Geometrical aspects of the BRST quantization of charged antisymmetric tensor fields and string fields are studied within the framework of the Batalin and Vilkovisky method. In both cases, candidate anomalies which obey the Wess-Zumino consistency conditions are given. (author). 18 refs, 1 fig

  12. String field theory solution for any open string background

    Czech Academy of Sciences Publication Activity Database

    Erler, T.; Maccaferri, Carlo

    2014-01-01

    Roč. 10, Oct (2014), 1-37 ISSN 1029-8479 R&D Projects: GA ČR GBP201/12/G028 Institutional support: RVO:68378271 Keywords : tachyon condensation * string field theory * conformal field models in string theory * bosonic strings Subject RIV: BE - Theoretical Physics Impact factor: 6.111, year: 2014

  13. Particle-in-cell simulations of plasma opening switch with external magnetic field

    International Nuclear Information System (INIS)

    Chen Yulan; Zeng Zhengzhong; Sun Fengju

    2003-01-01

    Fully electromagnetic particle-in-cell simulations are performed to study the effects of an external magnetic field on coaxial plasma opening switch (POS). The simulation results show that POS opening performance can be significantly improved only when external longitudinal magnetic field coils are placed at the cathode side, and an additional azimuthal magnetic field is effective whether the central electrode is of positive or negative polarity. Voltage multiplication coefficient K rises with the additional magnetic field increasing till the electron current is completely magnetically insulated during the opening of POS

  14. Analysis on temperature field and flow field of reactor core barrel openings for China experiment fast reactor

    International Nuclear Information System (INIS)

    Zhang Yabo; Yang Hongyi

    2008-01-01

    The paper gives analysis of the temperature and flow field around openings by software CFX, and figures out the flow direction around openings under CEFR normal condition. The calculation result is consistent with the test result of CAPX (the test-bed of decay heat removal system) and ground for the safety analysis later. (authors)

  15. Variation in Depth Dose Data between Open and Wedge Fields for 6 MV X-Rays

    International Nuclear Information System (INIS)

    U, Hong; Ryu, M. S. Samuel; Park, In Kyu

    1989-01-01

    Central axis depth dose data for 6 MV X-rays, including tissue maximum ratios, were measured for wedge fields according to Tatcher equation. In wedge fields, the differences in magnitude which increased with depth, field size, and wedge thickness increased when compared with the corresponding open field data. However, phantom scatter correction factors for wedge fields differed less that 1% from the corresponding open field factors. The differences in central axis percent depth dose between two types of fields indicated beam hardening by the wedge filter. The deviation of percent depth doses and scatter correction factors between the effective wedge field and the nominal wedge field at same angle was negligible. The differences were less than 3.26% between the nominal or effective wedge fields and the open fields for percent depth doses to the depth 7cm in 6cm x 6cm field. For larger (10cm x 10cm) field size, however, the deviation of percent depth doses between the nominal or effective wedge fields and the open fields were greater-dosimetric errors were 3.56% at depth 7cm and nearly 5.30% at 12cm. We suggest that the percent depth doses of individual wedge and wedge transmission factors should be considered for the dose calculation or monitor setting in the treatment of deep seated tumor

  16. Light-like tachyon condensation in open string field theory

    Czech Academy of Sciences Publication Activity Database

    Hellerman, S.; Schnabl, Martin

    2013-01-01

    Roč. 2013, č. 4 (2013), s. 1-34 ISSN 1126-6708 Institutional support: RVO:68378271 Keywords : string field theory * tachyon condensation Subject RIV: BE - Theoretical Physics Impact factor: 5.618, year: 2012

  17. Evidence that polar cap arcs occur on open field lines

    International Nuclear Information System (INIS)

    Gussenhoven, M.S.; Hardy, D.A.; Rich, F.J.; Mullen, E.G.; Redus, R.H.

    1990-01-01

    The characteristics of polar cap arc occurrence are reviewed to show that the assumption of a closed magnetospheric magnetic field topology at very high latitudes when the IMF B z is strongly northward is difficult to reconcile with a wide variety of observational and theoretical considerations. In particular, we consider the implications of observations of particle entry for high and low energy electrons, magnetic flux conservation between the near and far tail, the time sequencing in polar cap arcs events, and the hemispherical differences in polar cap arc observations. These points can be explained either by excluding the need for a major topological magnetic field change from explanations of polar cap arc dynamics, or by assuming a long-tailed magnetosphere for all IMF orientations in which magnetic field lines eventually merge with solar wind field lines in either a smooth or a patchy fashion. (author)

  18. Evidence for extreme divergence of open field lines from solar activity

    International Nuclear Information System (INIS)

    Dulk, G.A.; Suzuki, S.; Melrose, D.B.

    1979-01-01

    This paper reviews the evidence on the structure of the open magnetic field lines that emerge from solar active regions into interplanetary space. The evidence comes mainly from the measured sizes, positions and polarization of Type III and Type V bursts, and from electron streams observed from space. It is found that the observations are best interpreted in terms of a strongly-diverging field topology, with the open field lines filling a cone of angle approx. 60 0

  19. open-quotes High magnetic fields in the USAclose quotes

    International Nuclear Information System (INIS)

    Campbell, L.J.; Parkin, D.M.; Crow, J.E.; Schneider-Muntau, H.J.; Sullivan, N.S.

    1994-01-01

    During the past thirty years research using high magnetic fields has technically evolved in the manner, but not the magnitude, of the so-called big science areas of particle physics, plasma physics, neutron scattering, synchrotron light scattering, and astronomy. Starting from the laboratories of individual researchers it moved to a few larger universities, then to centralized national facilities with research and maintenance staffs, and, finally, to joint international ventures to build unique facilities, as illustrated by the subject of this conference. To better understand the nature of this type of research and its societal justification it is helpful to compare it, in general terms, with the aforementioned big-science fields. High magnetic field research differs from particle physics, plasma physics, and astronomy in three respects: (1) It is generic research that cuts across a wide range of scientific disciplines in physics, chemistry, biology, medicine, and engineering; (2) It studies materials and processes that are relevant for a variety of technological applications and it gives insight into biological processes; (3) It has produced, at least, comparably significant results with incomparably smaller resources. Unlike neutron and synchrotron light scattering, which probe matter, high magnetic fields change the thermodynamic state of matter. This change of state is fundamental and independent of other state variables, such as pressure and temperature. After the magnetic field is applied, various techniques are then used to study the new state

  20. Classical open-string field theory: A∞-algebra, renormalization group and boundary states

    International Nuclear Information System (INIS)

    Nakatsu, Toshio

    2002-01-01

    We investigate classical bosonic open-string field theory from the perspective of the Wilson renormalization group of world-sheet theory. The microscopic action is identified with Witten's covariant cubic action and the short-distance cut-off scale is introduced by length of open-string strip which appears in the Schwinger representation of open-string propagator. Classical open-string field theory in the title means open-string field theory governed by a classical part of the low energy action. It is obtained by integrating out suitable tree interactions of open-strings and is of non-polynomial type. We study this theory by using the BV formalism. It turns out to be deeply related with deformation theory of A ∞ -algebra. We introduce renormalization group equation of this theory and discuss it from several aspects. It is also discussed that this theory is interpreted as a boundary open-string field theory. Closed-string BRST charge and boundary states of closed-string field theory in the presence of open-string field play important roles

  1. Strain differences in the influence of open field exposure on sleep in mice.

    Science.gov (United States)

    Tang, Xiangdong; Xiao, Jihua; Liu, Xianling; Sanford, Larry D

    2004-09-23

    The open field (OF) is thought to induce anxiety in rodents. It also allows an opportunity for exploration in a novel environment. Less activity in the OF is thought to indicate greater anxiety whereas more activity may reflect greater exploration, and possibly greater exploratory learning. Anxiety and learning have poorly understood relationships to sleep. In order to determine how anxiety and exploration in the OF could influence sleep, we recorded sleep in mouse strains (C57BL/6J (B6), BALB/cJ (C), DBA/2J (D2), and CB6F1/J (CB6)) with different levels of anxiety and exploration after 30 min in an OF. In all strains, OF exposure induced immediate decreases in rapid eye movement sleep (REM) followed by longer latency increases in REM. The time course and amount of REM decreases and increases varied among strains. Compared to less anxious B6, D2 and CB6 mice, C mice had greater and longer lasting immediate decreases in REM. C mice also displayed longer periods of decreases REM and a smaller, longer latency increase in REM. OF exploratory activity was positively correlated to percentage of REM increases from 6 to 10h after OF exposure. The results suggest that the anxiogenic component of the OF produced an immediate decrease in REM that was greater in more "anxious" mice. In contrast, exploration in the OF was associated with increased REM, with the increase greater in less anxious mice. The results are discussed with respect to the potential influences of anxiety and learning on sleep.

  2. Behavioral and locomotor measurements using an open field activity monitoring system for skeletal muscle diseases.

    Science.gov (United States)

    Tatem, Kathleen S; Quinn, James L; Phadke, Aditi; Yu, Qing; Gordish-Dressman, Heather; Nagaraju, Kanneboyina

    2014-09-29

    The open field activity monitoring system comprehensively assesses locomotor and behavioral activity levels of mice. It is a useful tool for assessing locomotive impairment in animal models of neuromuscular disease and efficacy of therapeutic drugs that may improve locomotion and/or muscle function. The open field activity measurement provides a different measure than muscle strength, which is commonly assessed by grip strength measurements. It can also show how drugs may affect other body systems as well when used with additional outcome measures. In addition, measures such as total distance traveled mirror the 6 min walk test, a clinical trial outcome measure. However, open field activity monitoring is also associated with significant challenges: Open field activity measurements vary according to animal strain, age, sex, and circadian rhythm. In addition, room temperature, humidity, lighting, noise, and even odor can affect assessment outcomes. Overall, this manuscript provides a well-tested and standardized open field activity SOP for preclinical trials in animal models of neuromuscular diseases. We provide a discussion of important considerations, typical results, data analysis, and detail the strengths and weaknesses of open field testing. In addition, we provide recommendations for optimal study design when using open field activity in a preclinical trial.

  3. Open-field behavior of house mice selectively bred for high voluntary wheel-running.

    Science.gov (United States)

    Bronikowski, A M; Carter, P A; Swallow, J G; Girard, I A; Rhodes, J S; Garland, T

    2001-05-01

    Open-field behavioral assays are commonly used to test both locomotor activity and emotionality in rodents. We performed open-field tests on house mice (Mus domesticus) from four replicate lines genetically selected for high voluntary wheel-running for 22 generations and from four replicate random-bred control lines. Individual mice were recorded by video camera for 3 min in a 1-m2 open-field arena on 2 consecutive days. Mice from selected lines showed no statistical differences from control mice with respect to distance traveled, defecation, time spent in the interior, or average distance from the center of the arena during the trial. Thus, we found little evidence that open-field behavior, as traditionally defined, is genetically correlated with wheel-running behavior. This result is a useful converse test of classical studies that report no increased wheel-running in mice selected for increased open-field activity. However, mice from selected lines turned less in their travel paths than did control-line mice, and females from selected lines had slower travel times (longer latencies) to reach the wall. We discuss these results in the context of the historical open-field test and newly defined measures of open-field activity.

  4. Large BCFT moduli in open string field theory

    Czech Academy of Sciences Publication Activity Database

    Maccaferri, C.; Schnabl, Martin

    2015-01-01

    Roč. 2015, č. 8 (2015), s. 149 ISSN 1029-8479 R&D Projects: GA ČR(CZ) GA14-31689S Institutional support: RVO:68378271 Keywords : String Field Theory * tachyon condensation * D-branes Subject RIV: BE - Theoretical Physics Impact factor: 6.023, year: 2015

  5. Long Term Results of Visual Field Progression Analysis in Open Angle Glaucoma Patients Under Treatment.

    Science.gov (United States)

    Kocatürk, Tolga; Bekmez, Sinan; Katrancı, Merve; Çakmak, Harun; Dayanır, Volkan

    2015-01-01

    To evaluate visual field progression with trend and event analysis in open angle glaucoma patients under treatment. Fifteen year follow-up results of 408 eyes of 217 glaucoma patients who were followed at Adnan Menderes University, Department of Ophthalmology between 1998 and 2013 were analyzed retrospectively. Visual field data were collected for Mean Deviation (MD), Visual Field Index (VFI), and event occurrence. There were 146 primary open-angle glaucoma (POAG), 123 pseudoexfoliative glaucoma (XFG) and 139 normal tension glaucoma (NTG) eyes. MD showed significant change in all diagnostic groups (pfield indices. We herein report our fifteen year follow-up results in open angle glaucoma.

  6. Closed and open magnetic fields in stellar winds

    Science.gov (United States)

    Mullan, D. J.; Steinolfson, R. S.

    1983-01-01

    A numerical study of the interaction between a thermal wind and a global dipole field in the sun and in a giant star is reported. In order for closed field lines to persist near the equator (where a helmet-streamer-like configuration appears), the coronal temperature must be less than a critical value Tc, which scales as M/R. This condition is found to be equivalent to the following: for a static helmet streamer to persist, the sonic point above the helmet must not approach closer to the star than 2.2-2.6 stellar radii. Implications for rapid mass loss and X-ray emission from cool giants are pointed out. The results strengthen the case for identifying empirical dividing lines in the H-R diagram with a magnetic topology transition locus (MTTL). Support for the MTTL concept is also provided by considerations of the breakdown of magnetostatic equilibrium.

  7. Comments on complete actions for open superstring field theory

    International Nuclear Information System (INIS)

    Matsunaga, Hiroaki

    2016-01-01

    We clarify a Wess-Zumino-Witten-like structure including Ramond fields and propose one systematic way to construct gauge invariant actions: Wess-Zumino-Witten-like complete action S_W_Z_W. We show that Kunitomo-Okawa’s action proposed in http://arxiv.org/abs/1508.00366 can obtain a topological parameter dependence of Ramond fields and belongs to our WZW-like framework. In this framework, once a WZW-like functional A_η=A_η[Ψ] of a dynamical string field Ψ is constructed, we obtain one realization of S_W_Z_W[Ψ] parametrized by Ψ. On the basis of this way, we construct an action S̃ whose on-shell condition is equivalent to the Ramond equations of motion proposed in http://arxiv.org/abs/1506.05774. Using these results, we provide the equivalence of two theories: http://arxiv.org/abs/1508.00366 and http://arxiv.org/abs/1506.05774.

  8. Mean field dynamics of some open quantum systems.

    Science.gov (United States)

    Merkli, Marco; Rafiyi, Alireza

    2018-04-01

    We consider a large number N of quantum particles coupled via a mean field interaction to another quantum system (reservoir). Our main result is an expansion for the averages of observables, both of the particles and of the reservoir, in inverse powers of [Formula: see text]. The analysis is based directly on the Dyson series expansion of the propagator. We analyse the dynamics, in the limit [Formula: see text], of observables of a fixed number n of particles, of extensive particle observables and their fluctuations, as well as of reservoir observables. We illustrate our results on the infinite mode Dicke model and on various energy-conserving models.

  9. Mean field dynamics of some open quantum systems

    Science.gov (United States)

    Merkli, Marco; Rafiyi, Alireza

    2018-04-01

    We consider a large number N of quantum particles coupled via a mean field interaction to another quantum system (reservoir). Our main result is an expansion for the averages of observables, both of the particles and of the reservoir, in inverse powers of √{N }. The analysis is based directly on the Dyson series expansion of the propagator. We analyse the dynamics, in the limit N →∞ , of observables of a fixed number n of particles, of extensive particle observables and their fluctuations, as well as of reservoir observables. We illustrate our results on the infinite mode Dicke model and on various energy-conserving models.

  10. [Genetic variation and differentiation in striped field mouse Apodemus agrarius inferred from RAPD-PCR analysis].

    Science.gov (United States)

    Atopkin, D M; Bogdanov, A S; Chelomina, G N

    2007-06-01

    Genetic variation and differentiation of the trans-Palearctic species Apodemus agrarius (striped field mouse), whose range consists of two large isolates-European-Siberian and Far Eastern-Chinese, were examined using RAPD-PCR analysis. The material from the both parts of the range was examined (41 individual of A. agrarius from 18 localities of Russia, Ukraine, Moldova, and Kazakhstan); the Far-Eastern part was represented by samples from the Amur region, Khabarovsk krai, and Primorye (Russia). Differences in frequencies of polymorphic RAPD loci were found between the European-Siberian and the Far Eastern population groups of striped field mouse. No "fixed" differences between them in RAPD spectra were found, and none of the used statistical methods permitted to distinguish with absolute certainty animals from the two range parts. Thus, genetic isolation of the European-Siberian and the Far Eastern population groups of A. agrarius is not strict. These results support the hypothesis on recent dispersal of striped field mouse from East to West Palearctics (during the Holocene climatic optimum, 7000 to 4500 years ago) and subsequent disjunction of the species range (not earlier than 4000-4500 years ago). The Far Eastern population group is more polymorphic than the European-Siberian one, while genetic heterogeneity is more uniformly distributed within it. This is probably explained by both historical events that happened during the species dispersal in the past, and different environmental conditions for the species in different parts of its range. The Far Eastern population group inhabits the area close to the distribution center of A. agrarius. It is likely that this group preserved genetic variation of the formerly integral ancestral form, while some amount of genetic polymorphism could be lost during the species colonization of the Siberian and European areas. To date, the settlement density and population number in general are higher than within the European

  11. GPR30 activation decreases anxiety in the open field test but not in the elevated plus maze test in female mice.

    Science.gov (United States)

    Anchan, Divya; Clark, Sara; Pollard, Kevin; Vasudevan, Nandini

    2014-01-01

    The GPR30 is a novel estrogen receptor (ER) that is a candidate membrane ER based on its binding to 17β estradiol and its rapid signaling properties such as activation of the extracellular-regulated kinase (ERK) pathway. Its distribution in the mouse limbic system predicts a role for this receptor in the estrogenic modulation of anxiety behaviors in the mouse. A previous study showed that chronic administration of a selective agonist to the GPR30 receptor, G-1, in the female rat can improve spatial memory, suggesting that GPR30 plays a role in hippocampal-dependent cognition. In this study, we investigated the effect of a similar chronic administration of G-1 on behaviors that denote anxiety in adult ovariectomized female mice, using the elevated plus maze (EPM) and the open field test as well as the activation of the ERK pathway in the hippocampus. Although estradiol benzoate had no effect on behaviors in the EPM or the open field, G-1 had an anxiolytic effect solely in the open field that was independent of ERK signaling in either the ventral or dorsal hippocampus. Such an anxiolytic effect may underlie the ability of G-1 to increase spatial memory, by acting on the hippocampus.

  12. Prototypical anxiolytics do not reduce anxiety-like behavior in the open field in C57BL/6J mice.

    Science.gov (United States)

    Thompson, Trey; Grabowski-Boase, Laura; Tarantino, Lisa M

    2015-06-01

    Understanding and effectively treating anxiety disorders are a challenge for both scientists and clinicians. Despite a variety of available therapies, the efficacy of current treatments is still not optimal and adverse side effects can result in non-compliance. Animal models have been useful for studying the underlying biology of anxiety and assessing the anxiolytic properties of potential therapeutics. The open field (OF) is a commonly used assay of anxiety-like behavior. The OF was developed and validated in rats and then transferred to use in the mouse with only limited validation. The present study tests the efficacy of prototypical benzodiazepine anxiolytics, chlordiazepoxide (CDP) and diazepam (DZ), for increasing center time in the OF in C57BL/6J (B6) mice. Multiple doses of CDP and DZ did not change time spent in the center of the OF. Increasing illumination in the OF did not alter these results. The non-benzodiazepine anxiolytic, buspirone (BUSP) also failed to increase center time in the OF while the anxiogenic meta-chlorophenylpiperazine (mCPP) increased center time. Additional inbred mouse strains, BALB/cJ (BALB) and DBA/2J (D2) did not show any change in center time in response to CDP. Moreover, evaluation of CDP in B6 mice in the elevated plus maze (EPM), elevated zero maze (EZM) and light dark assay (LD) did not reveal changes in anxiety-like behavior while stress-induced hyperthermia (SIH) was decreased by DZ. Pharmacokinetic (PK) studies suggest that adequate CDP is present to induce anxiolysis. We conclude that the measure of center time in the OF does not show predictive validity for anxiolysis in these inbred mouse strains. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. On Field Theory of Open Strings, Tachyon Condensation and Closed Strings

    OpenAIRE

    Shatashvili, Samson L.

    2001-01-01

    I review the physical properties of different vacua in the background independent open string field theory. Talk presented at Strings 2001, Mumbai, India, http://theory.theory.tifr.res.in/strings/Proceedings/#sha-s.

  14. Standardized UXO Technology Demonstration Site Open Field Scoring Record No. 901 (Sky Research, Inc.)

    National Research Council Canada - National Science Library

    McClung, J. S; Fling, Rick; McClung, Christina; Burch, William; Lombardo, Leonardo; McDonnell, Patrick

    2008-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. This Scoring Record was coordinated by Stephen McClung and the Standardized UXO Technology Demonstration Site Scoring Committee...

  15. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 245

    National Research Council Canada - National Science Library

    Overbay, Larry

    2005-01-01

    ... (UXO) utilizing the YPG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  16. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 675

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ... (UXO) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  17. Scaling law in free walking of mice in circular open fields of various diameters.

    Science.gov (United States)

    Shoji, Hiroto

    2016-03-01

    Open-field tests are routinely used to study locomotor activity in rodents. I studied the effects of apparatus size on rodent locomotor activity, specifically with respect to how resting and walking periods are interwoven. I explored the open-field behavior of mice utilizing circular open fields of various diameters. When the diameter of the test apparatus was greater than 75 cm, the durations of the resting and moving periods of free walking behavior obeyed bounded power-law distribution functions. I found that the properties of the scaling exponents and model selection became similar for test apparatus diameters greater than 75 cm. These results can provide a guide for the selection of the size of the test apparatus for use in the study of the open-field behavior of rodents.

  18. FAIMS Mobile: Flexible, open-source software for field research

    Science.gov (United States)

    Ballsun-Stanton, Brian; Ross, Shawn A.; Sobotkova, Adela; Crook, Penny

    2018-01-01

    FAIMS Mobile is a native Android application supported by an Ubuntu server facilitating human-mediated field research across disciplines. It consists of 'core' Java and Ruby software providing a platform for data capture, which can be deeply customised using 'definition packets' consisting of XML documents (data schema and UI) and Beanshell scripts (automation). Definition packets can also be generated using an XML-based domain-specific language, making customisation easier. FAIMS Mobile includes features allowing rich and efficient data capture tailored to the needs of fieldwork. It also promotes synthetic research and improves transparency and reproducibility through the production of comprehensive datasets that can be mapped to vocabularies or ontologies as they are created.

  19. A note on T-duality, open strings in B-field background and canonical transformations

    International Nuclear Information System (INIS)

    Sheikh-Jabbari, M.M.

    1999-11-01

    In this paper we study T-duality for open strings ending on branes with non-zero B-field on them from the point of view of canonical transformations. For the particular case of type II strings on the two torus we show that the Sl(2, Z) N transformations can be understood as a sub-class of canonical transformations on the open strings in the B-field background. (author)

  20. Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

    OpenAIRE

    Tatem, Kathleen S.; Quinn, James L.; Phadke, Aditi; Yu, Qing; Gordish-Dressman, Heather; Nagaraju, Kanneboyina

    2014-01-01

    The open field activity monitoring system comprehensively assesses locomotor and behavioral activity levels of mice. It is a useful tool for assessing locomotive impairment in animal models of neuromuscular disease and efficacy of therapeutic drugs that may improve locomotion and/or muscle function. The open field activity measurement provides a different measure than muscle strength, which is commonly assessed by grip strength measurements. It can also show how drugs may affect other body sy...

  1. Correlation between two parameters of mice behaviour in the open field test

    OpenAIRE

    Stojanović, Nikola M.; Ranđelović, Pavle J.; Radulović, Niko S.

    2017-01-01

    The open field test is being used extensively for the determination of different aspects of animal behaviour for over seventy years. The correlation between different behavioural parameters obtained in this test, although previously studied, is still debatable. Thus, we aimed to analyze and correlate behaviour scores to estimate the importance of individual parameters in this type of experiment. The open field test was performed on male BALB/c mice treated with either saline (10 ml/kg) or dia...

  2. A hybrid analytical model for open-circuit field calculation of multilayer interior permanent magnet machines

    Science.gov (United States)

    Zhang, Zhen; Xia, Changliang; Yan, Yan; Geng, Qiang; Shi, Tingna

    2017-08-01

    Due to the complicated rotor structure and nonlinear saturation of rotor bridges, it is difficult to build a fast and accurate analytical field calculation model for multilayer interior permanent magnet (IPM) machines. In this paper, a hybrid analytical model suitable for the open-circuit field calculation of multilayer IPM machines is proposed by coupling the magnetic equivalent circuit (MEC) method and the subdomain technique. In the proposed analytical model, the rotor magnetic field is calculated by the MEC method based on the Kirchhoff's law, while the field in the stator slot, slot opening and air-gap is calculated by subdomain technique based on the Maxwell's equation. To solve the whole field distribution of the multilayer IPM machines, the coupled boundary conditions on the rotor surface are deduced for the coupling of the rotor MEC and the analytical field distribution of the stator slot, slot opening and air-gap. The hybrid analytical model can be used to calculate the open-circuit air-gap field distribution, back electromotive force (EMF) and cogging torque of multilayer IPM machines. Compared with finite element analysis (FEA), it has the advantages of faster modeling, less computation source occupying and shorter time consuming, and meanwhile achieves the approximate accuracy. The analytical model is helpful and applicable for the open-circuit field calculation of multilayer IPM machines with any size and pole/slot number combination.

  3. Identification of High-Variation Fields based on Open Satellite Imagery

    DEFF Research Database (Denmark)

    Jeppesen, Jacob Høxbroe; Jacobsen, Rune Hylsberg; Nyholm Jørgensen, Rasmus

    2017-01-01

    . The categorization is based on vegetation indices derived from Sentinel-2 satellite imagery. A case study on 7678 winter wheat fields is presented, which employs open data and open source software to analyze the satellite imagery. Furthermore, the method can be automated to deliver categorizations at every update......This paper proposes a simple method for categorizing fields on a regional level, with respect to intra-field variations. It aims to identify fields where the potential benefits of applying precision agricultural practices are highest from an economic and environmental perspective...

  4. Enriched open field facilitates exercise and social interaction in 2 strains of guinea pigs (Cavia porcellus).

    Science.gov (United States)

    Brewer, Jacob S; Bellinger, Seanceray A; Joshi, Prianca; Kleven, Gale A

    2014-07-01

    Current housing guidelines for laboratory rodents include recommendations for enrichment. Working with guinea pigs, we have developed an open-field enrichment paradigm that provides several aspects of this species' natural environment. These naturalistic aspects include access to increased space for exploration, access to western timothy (Phleum pratense L.) hay, and grouping as a herd to facilitate social interaction. To determine the immediate effect on behavior from access to the enriched environment, female guinea pigs from 2 strains, IAF Hairless and NIH Hartley, were observed in both standard home cages and an open-field enriched environment. Subjects were housed with cagemates in pairs for the home-cage observation and were grouped as a herd when in the open-field arena. Behaviors were videorecorded for 1 h and then scored. Salivary cortisol levels were measured both prior to and immediately after behavioral observations. Analyses revealed higher levels of activity and social interaction in the open-field arena compared with the home cage, with no significant change in salivary cortisol levels. These results suggest that exposure to the open-field environment provide increased opportunities for exercise and social enrichment. Although additional studies are needed to determine long-term effects on experimental outcomes, the open-field configuration holds promise as a laboratory enrichment paradigm for guinea pigs.

  5. Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats.

    Science.gov (United States)

    Shaw, D; Annett, J M; Doherty, B; Leslie, J C

    2007-09-01

    To establish a valid animal model of the effects of olfactory stimuli on anxiety, a series of experiments was conducted using rats in an open-field test. Throughout, effects of lavender oil were compared with the effects of chlordiazepoxide (CDP), as a reference anxiolytic with well-known effects on open-field behaviour. Rats were exposed to lavender oil (0.1-1.0 ml) for 30 min (Experiment 1) or 1h (Experiment 2) prior to open-field test and in the open field or injected with CDP (10 mg/kg i.p.). CDP had predicted effects on behaviour, and the higher doses of lavender oil had some effects on behaviour similar to those of CDP. In Experiment 3, various combinations of pre-exposure times and amounts of lavender oil were used. With sufficient exposure time and quantity of lavender the same effects were obtained as in Experiment 2. Experiment 4 demonstrated that these behavioural effects of lavender could be obtained following pre-exposure, even if no oil was present in the open-field test. In Experiments 2-4, lavender oil increased immobility. Together, these experiments suggest that lavender oil does have anxiolytic effects in the open field, but that a sedative effect can also occur at the highest doses.

  6. Restudy of the open-superstring tree amplitudes by looking at their field-theoretical limits

    International Nuclear Information System (INIS)

    Hsu, R.; Yeung, W.B.; Yu, H.L.

    1987-01-01

    We carry out complete computations of some open- and closed-superstring tree amplitudes by using the bosonized covariant vertices. Some open-superstring amplitudes so obtained are shown to be different from those obtained in the light-cone gauge approach by some numerical factors. The low-energy limits of our five open-superstring amplitudes are then shown to match the five super Yang-Mills field amplitudes while the five light-cone gauge open-superstring amplitudes fail to do so

  7. Solar Open Flux Migration from Pole to Pole: Magnetic Field Reversal.

    Science.gov (United States)

    Huang, G-H; Lin, C-H; Lee, L C

    2017-08-25

    Coronal holes are solar regions with low soft X-ray or low extreme ultraviolet intensities. The magnetic fields from coronal holes extend far away from the Sun, and thus they are identified as regions with open magnetic field lines. Coronal holes are concentrated in the polar regions during the sunspot minimum phase, and spread to lower latitude during the rising phase of solar activity. In this work, we identify coronal holes with outward and inward open magnetic fluxes being in the opposite poles during solar quiet period. We find that during the sunspot rising phase, the outward and inward open fluxes perform pole-to-pole trans-equatorial migrations in opposite directions. The migration of the open fluxes consists of three parts: open flux areas migrating across the equator, new open flux areas generated in the low latitude and migrating poleward, and new open flux areas locally generated in the polar region. All three components contribute to the reversal of magnetic polarity. The percentage of contribution from each component is different for different solar cycle. Our results also show that the sunspot number is positively correlated with the lower-latitude open magnetic flux area, but negatively correlated with the total open flux area.

  8. A method for opening a mine field which is adjacent to a pit

    Energy Technology Data Exchange (ETDEWEB)

    Onishchenko, V.I.; Grebenyuk, V.K.; Kukharev, V.N.; Martynenko, V.P.; Omelnitskiy, A.G.; Sallin, V.I.; Sidorov, A.S.

    1982-01-01

    The method for opening a mine field adjacent to a pit includes the construction of the main and auxiliary opening drifts in the pit and the surface complex of the mine through assembling a support with subsequent filling of them by tailings of the covering rock. In order to increase the productive capacity of the mine, to reduce capital expenditures and to increase the safety of underground operations, a base is first formed from the tailing rock along the front of the open mining operations, from the bottom of the pit at the level of the stratum being opened to the surface with simultaneous layer by layer packing of the cited base, after which the opening drifts are built on this base. The mouth of the main opening drifts and the surface complex of the mine are positioned in the region of the pit.

  9. Magnetar giant flares in multipolar magnetic fields. I. Fully and partially open eruptions of flux ropes

    International Nuclear Information System (INIS)

    Huang, Lei; Yu, Cong

    2014-01-01

    We propose a catastrophic eruption model for the enormous energy release of magnetars during giant flares, in which a toroidal and helically twisted flux rope is embedded within a force-free magnetosphere. The flux rope stays in stable equilibrium states initially and evolves quasi-statically. Upon the loss of equilibrium, the flux rope cannot sustain the stable equilibrium states and erupts catastrophically. During the process, the magnetic energy stored in the magnetosphere is rapidly released as the result of destabilization of global magnetic topology. The magnetospheric energy that could be accumulated is of vital importance for the outbursts of magnetars. We carefully establish the fully open fields and partially open fields for various boundary conditions at the magnetar surface and study the relevant energy thresholds. By investigating the magnetic energy accumulated at the critical catastrophic point, we find that it is possible to drive fully open eruptions for dipole-dominated background fields. Nevertheless, it is hard to generate fully open magnetic eruptions for multipolar background fields. Given the observational importance of the multipolar magnetic fields in the vicinity of the magnetar surface, it would be worthwhile to explore the possibility of the alternative eruption approach in multipolar background fields. Fortunately, we find that flux ropes may give rise to partially open eruptions in the multipolar fields, which involve only partial opening of background fields. The energy release fractions are greater for cases with central-arcaded multipoles than those with central-caved multipoles that emerged in background fields. Eruptions would fail only when the centrally caved multipoles become extremely strong.

  10. A hybrid analytical model for open-circuit field calculation of multilayer interior permanent magnet machines

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Zhen [School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072 (China); Xia, Changliang [School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072 (China); Tianjin Engineering Center of Electric Machine System Design and Control, Tianjin 300387 (China); Yan, Yan, E-mail: yanyan@tju.edu.cn [School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072 (China); Geng, Qiang [Tianjin Engineering Center of Electric Machine System Design and Control, Tianjin 300387 (China); Shi, Tingna [School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072 (China)

    2017-08-01

    Highlights: • A hybrid analytical model is developed for field calculation of multilayer IPM machines. • The rotor magnetic field is calculated by the magnetic equivalent circuit method. • The field in the stator and air-gap is calculated by subdomain technique. • The magnetic scalar potential on rotor surface is modeled as trapezoidal distribution. - Abstract: Due to the complicated rotor structure and nonlinear saturation of rotor bridges, it is difficult to build a fast and accurate analytical field calculation model for multilayer interior permanent magnet (IPM) machines. In this paper, a hybrid analytical model suitable for the open-circuit field calculation of multilayer IPM machines is proposed by coupling the magnetic equivalent circuit (MEC) method and the subdomain technique. In the proposed analytical model, the rotor magnetic field is calculated by the MEC method based on the Kirchhoff’s law, while the field in the stator slot, slot opening and air-gap is calculated by subdomain technique based on the Maxwell’s equation. To solve the whole field distribution of the multilayer IPM machines, the coupled boundary conditions on the rotor surface are deduced for the coupling of the rotor MEC and the analytical field distribution of the stator slot, slot opening and air-gap. The hybrid analytical model can be used to calculate the open-circuit air-gap field distribution, back electromotive force (EMF) and cogging torque of multilayer IPM machines. Compared with finite element analysis (FEA), it has the advantages of faster modeling, less computation source occupying and shorter time consuming, and meanwhile achieves the approximate accuracy. The analytical model is helpful and applicable for the open-circuit field calculation of multilayer IPM machines with any size and pole/slot number combination.

  11. Strain Differences of Mice for Open Field Behaviour, Circadian Rhythms,and Morphine Reactivity

    OpenAIRE

    Sekiguchi, Shigehisa

    1982-01-01

    This paper deals with some of the work in the field of Behaviour Genetics at the Psychological Laboratory in Shiga University. The first part concerns open field behaviour, the second part discusses circadian rhythms of general activity and of sleepwakefulness cycle, and the third part relates to morphine effects on avoidance behaviour.

  12. Boundary string field theory and an open string one-loop

    International Nuclear Information System (INIS)

    Lee, Tae Jin; Viswanathan, K. S.; Yang, Yi

    2003-01-01

    We discuss the open string one-loop partition function in the tachyon condensation background of an unstable D-brane system. We evaluate the partition function by using the boundary-state formulation and find that it is in complete agreement with the result obtained in the boundary string field theory. This suggests that the open string higher loop diagrams may be produced consistently by using a closed string field theory, where the D-brane plays the role of a source for the closed string field

  13. Similar reliability and equivalent performance of female and male mice in the open field and water-maze place navigation task

    OpenAIRE

    Fritz, Ann-Kristina; Amrein, Irmgard; Wolfer, David P.

    2017-01-01

    Although most nervous system diseases affect women and men differentially, most behavioral studies using mouse models do not include subjects of both sexes. Many researchers worry that data of female mice may be unreliable due to the estrous cycle. Here, we retrospectively evaluated sex effects on coefficient of variation (CV) in 5,311 mice which had performed the same place navigation protocol in the water-maze and in 4,554 mice tested in the same open field arena. Confidence intervals for C...

  14. Olfactory source localization in the open field using one or both nostrils.

    Science.gov (United States)

    Welge-Lussen, A; Looser, G L; Westermann, B; Hummel, T

    2014-03-01

    This study aims to examine humans ́ abilities to localize odorants within the open field. Young participants were tested on a localization task using a relatively selective olfactory stimulus (2-phenylethyl-alcohol, PEA) and cineol, an odorant with a strong trigeminal component. Participants were blindfolded and had to localize an odorant source at 2 m distance (far-field condition) and a 0.4 m distance (near-field condition) with either two nostrils open or only one open nostril. For the odorant with trigeminal properties, the number of correct trials did not differ when one or both nostrils were used, while more PEA localization trials were correctly completed with both rather than one nostril. In the near-field condition, correct localization was possible in 72-80% of the trials, irrespective of the odorant and the number of nostrils used. Localization accuracy, measured as spatial deviation from the olfactory source, was significantly higher in the near-field compared to the far-field condition, but independent of the odorant being localized. Odorant localization within the open field is difficult, but possible. In contrast to the general view, humans seem to be able to exploit the two-nostril advantage with increasing task difficulty.

  15. Comparison of The Effects of Vitrification on Gene Expression of Mature Mouse Oocytes Using Cryotop and Open Pulled Straw

    Directory of Open Access Journals (Sweden)

    Fardin Amidi

    2018-01-01

    Full Text Available Background Oocyte cryopreservation is an essential part of the assisted reproductive technology (ART, which was recently introduced into clinical practice. This study aimed to evaluate the effects of two vitrification systems-Cryotop and Open Pulled Straw (OPS-on mature oocytes gene expressions. Materials and Methods In this experimental study, the survival rate of metaphase II (MII mouse oocytes were assessed after cryopreservation by vitrification via i. OPS or ii. Cryotop. Then we compared the fertilization rate of oocytes produced via these two methods. In the second experiment, we determined the effects of the two vitrification methods on the expression of Hspa1a, mn-Sod, and ß-actin genes in vitrified-warmed oocytes. Denuded MII oocytes were vitrified in two concentrations of vitrification solution (VS1 and VS2 by Cryotop and straw. We then compared the results using the two vitrification methods with fresh control oocytes. Results mn-Sod expression increased in the vitrified-warmed group both in OPS and Cryotop compared with the con- trols. We only detected Hspa1a in VS1 and control groups using Cryotop. The survival rate of the oocytes was 91.2% (VS1 and 89.2% (VS2 in the Cryotop groups (P=0.902 and 85.5% (VS1 and 83.6% (VS2 in the OPS groups (P=0.905. There were no significant differences between the Cryotop and the OPS groups (P=0.927. The survival rate in the Cryotop or the OPS groups was, nevertheless, significantly lower than the control group (P<0.001. The fertilization rates of the oocytes were 39% (VS1 and 34% (VS2 in the Cryotop groups (P=0.902 and 29 %( VS1 and 19.7% (VS2 in the OPS groups (P=0.413. The fertilization rates were achieved without significant differences among the Cryotop and OPS groups (P=0.755. Conclusion Our results indicated that Cryotop vitrification increases both cooling and warming rates, but both Cryo- top and OPS techniques have the same effect on the mouse oocytes after vitrification.

  16. Effects of a single inhalative exposure to formaldehyde on the open field behavior of mice.

    Science.gov (United States)

    Malek, Fathi A; Möritz, Klaus-Uwe; Fanghänel, Jochen

    2004-02-01

    The effects of formaldehyde on the explorative behavior and locomotor activity of mice after a single inhalative exposure were examined in an open field. Adult male mice were exposed to approximately 1.1 ppm, 2.3 ppm, or 5.2 ppm formaldehyde vapour for 2 hours and the open field test was carried out two hours after the end of exposure (trial 1) and repeated 24 hours thereafter (trial 2). The following behavioral parameters were quantitatively examined: numbers of crossed floor squares (inner, peripheral, total), sniffing, grooming, rearing, climbing, and incidence of fecal boli. The results of the first trial revealed that the motion activity was significantly reduced in all exposed groups. In the 1.1 ppm group, the frequency of rearing was reduced and that of floor sniffing increased. The exposure to the two higher formaldehyde concentrations caused a significant decrease in total numbers of floor squares crossed by the subjects, air sniffing, and rearing. The open field test on the next day (trial 2) showed that the frequencies of floor sniffing, grooming, and rearing in all formaldehyde groups were significantly altered. In the 2.5 ppm group, an increased incidence of fecal boli was observed. From the results obtained, we conclude that the exposure of male mice to formaldehyde vapour affects their locomotor and explorative activity in the open field, and that some open field parameters are still altered in the exposed animals even after 24 hours.

  17. Dependence of the amount of open magnetic flux on the direction of the interplanetary magnetic field

    International Nuclear Information System (INIS)

    Akasofu, S.I.; Ahn, B.H.

    1980-01-01

    The power generated by the solar wind-magnetosphere dynamo is proportional to the amount of the open magnetic flux phi. It is difficult to use this fact in determining observationally the dependence of phi on the orientation of the interplanetary magnetic field vector. It is shown that, for a simple vacuum superposition of the earth's dipole field and a uniform magnetic field, PHI is very closely proportional to sin(theta/2) for a wide range of the intensity of the uniform field, where theta denotes the polar angle of the interplanetary magnetic field vector in the Y-Z plane of solar-magnetospheric coordinates. (author)

  18. UV / IR mixing in noncommutative field theory via open string loops

    International Nuclear Information System (INIS)

    Kiem, Youngjai; Lee, Sangmin

    2000-01-01

    We explicitly evaluate one-loop (annulus) planar and nonplanar open string amplitudes in the presence of the background NS-NS two-form field. In the decoupling limit of Seiberg and Witten, we find that the nonplanar string amplitudes reproduce the UV/IR mixing of noncommutative field theories. In particular, the investigation of the UV regime of the open string amplitudes shows that certain IR closed string degrees of freedom survive the decoupling limit as previously predicted from the noncommutative field theory analysis. These degrees of freedom are responsible for the quadratic, linear and logarithmic IR singularities when the D-branes embedded in space-time have the codimension zero, one and two, respectively. The analysis is given for both bosonic and supersymmetric open strings

  19. Mice selectively bred for open-field thigmotaxis: life span and stability of the selection trait.

    Science.gov (United States)

    Leppänen, Pia K; Ewalds-Kvist, S Béatrice M; Selander, Ritva-Kajsa

    2005-04-01

    In 2 experiments, the authors examined 69 mice selectively bred for high or low levels of open-field (OF) thigmotactic behavior (high open-field thigmotaxis [HOFT] and low open-field thigmotaxis [LOFT], respectively). They found that the strains differed in defecation during the 60-min exposure to the OF. Furthermore, the strains differed with regard to their life spans: The more thigmotactic HOFT mice lived longer than the LOFT mice. The strains were not differentiated by food intake or excretion. The strain difference in thigmotaxis was not age dependent, and it persisted in the home-cage condition as well. Neither the location (center or wall) of the starting point nor the shape (circular or square) of the OF arena affected the difference in wall-seeking behavior between the two strains. The authors concluded that the difference in thigmotaxis (or emotionality) between the HOFT and LOFT mice is a stable and robust feature of these animals.

  20. In situ analysis of soil at an open burning/open detonation disposal facility: J-Field, Aberdeen Proving Ground, Maryland

    International Nuclear Information System (INIS)

    Martino, L.; Cho, E.; Wrobel, J.

    1994-01-01

    Investigators have used a field-portable X-Ray Fluorescence (XRF) Analyzer to screen soils for a suite of metals indicative of the open burning and open detonation (OB/OD) activities that occurred at the J-Field site at Aberdeen Proving Ground, Maryland. The field XRF results were incorporated into a multiphase investigation of contaminants at the Toxic Burning Pits Area of Concern at J-Field. The authors determined that the field-portable XRF unit used for the study and the general concept of field XRF screening are invaluable tools for investigating an OB/OD site where intrusive sampling techniques could present unacceptable hazards to site workers

  1. Differential Receptive Field Properties of Parvalbumin and Somatostatin Inhibitory Neurons in Mouse Auditory Cortex.

    Science.gov (United States)

    Li, Ling-Yun; Xiong, Xiaorui R; Ibrahim, Leena A; Yuan, Wei; Tao, Huizhong W; Zhang, Li I

    2015-07-01

    Cortical inhibitory circuits play important roles in shaping sensory processing. In auditory cortex, however, functional properties of genetically identified inhibitory neurons are poorly characterized. By two-photon imaging-guided recordings, we specifically targeted 2 major types of cortical inhibitory neuron, parvalbumin (PV) and somatostatin (SOM) expressing neurons, in superficial layers of mouse auditory cortex. We found that PV cells exhibited broader tonal receptive fields with lower intensity thresholds and stronger tone-evoked spike responses compared with SOM neurons. The latter exhibited similar frequency selectivity as excitatory neurons. The broader/weaker frequency tuning of PV neurons was attributed to a broader range of synaptic inputs and stronger subthreshold responses elicited, which resulted in a higher efficiency in the conversion of input to output. In addition, onsets of both the input and spike responses of SOM neurons were significantly delayed compared with PV and excitatory cells. Our results suggest that PV and SOM neurons engage in auditory cortical circuits in different manners: while PV neurons may provide broadly tuned feedforward inhibition for a rapid control of ascending inputs to excitatory neurons, the delayed and more selective inhibition from SOM neurons may provide a specific modulation of feedback inputs on their distal dendrites. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  2. On open and closed field line regions in Tsyganenko's field model and their possible associations with horse collar auroras

    Science.gov (United States)

    Birn, J.; Hones, E. W., Jr.; Craven, J. D.; Frank, L. A.; Elphinstone, R. D.; Stern, D. P.

    1991-01-01

    The boundary between open and closed field lines is investigated in the empirical Tsyganenko (1987) magnetic field model. All field lines extending to distances beyond -70 R(E), the tailward velocity limit of the Tsyganenko model are defined as open, while all other field lines, which cross the equatorial plane earthward of -70 R(E) and are connected with the earth at both ends, are assumed closed. It is found that this boundary at the surface of the earth, identified as the polar cap boundary, can exhibit the arrowhead shape, pointed toward the sun, which is found in horse collar auroras. For increasing activity levels, the polar cap increases in area and becomes rounder, so that the arrowhead shape is less pronounced. The presence of a net B(y) component can also lead to considerable rounding of the open flux region. The arrowhead shape is found to be closely associated with the increase of B(z) from the midnight region to the flanks of the tail, consistent with a similar increase of the plasma sheet thickness.

  3. Magnetic field propagation in a two ion species planar plasma opening switch

    International Nuclear Information System (INIS)

    Strauss, H. R.; Doron, R.; Arad, R.; Rubinstein, B.; Maron, Y.; Fruchtman, A.

    2007-01-01

    Three fluid plasma evolution equations are applied to the problem of magnetic field propagation in a planar plasma opening switch. For certain initial conditions in which Hall parameter H∼1, magnetic field penetration due to the Hall field, initially, as expected, either opposes or adds to the hydromagnetic pushing, depending on the polarity of the magnetic field relative to the density gradient. Later, however, the plasma pushing by the magnetic field is found in the case studied here to modify the plasma density in a way that the density gradient tends to align with the magnetic field gradient, effectively turning off the Hall effect. The penetration of the magnetic field then ceases and plasma pushing becomes the dominant process

  4. [Effect of genotype and day or night time of testing on mice behavior in the light-dark box and the open-field tests].

    Science.gov (United States)

    Morozova, M V; Kulikov, A V

    2010-01-01

    The light-dark box (LDB) and the open-field (OF) tests are widespread experimental models for studying locomotion and anxiety in laboratory rats and mice. The fact that rodents are nocturnal animals and more active at night raises a critical question of whether behavioral experiments carried out in the light phase are methodologically correct. Parameters of behavior of four mouse strains (C57BL/6J, DBA2/J, AKR/J and CBA/LacJ) in the light-dark box and open-field tests in the light and dark phases were compared. No significant influence of the phase of testing on anxiety in LDB and OF tests was revealed. In the OF test CBA mice showed increased locomotor activity, whereas AKR and C57BL/6 mice showed increased defecation in the dark phase. It was concluded that: 1) the phase of testing is not crucial for the expression of anxiety in LDB and OF; 2) the sensitivity to the phase of testing depends on the genotype; 3) the indices of behavior in the genotypes sensitive to the phase of testing (locomotion in the CBA and defecation in the AKR and C57BL/6 mouse strains) are increased in the dark phase.

  5. Confinement of plasma along shaped open magnetic fields from the centrifugal force of supersonic plasma rotation.

    Science.gov (United States)

    Teodorescu, C; Young, W C; Swan, G W S; Ellis, R F; Hassam, A B; Romero-Talamas, C A

    2010-08-20

    Interferometric density measurements in plasmas rotating in shaped, open magnetic fields demonstrate strong confinement of plasma parallel to the magnetic field, with density drops of more than a factor of 10. Taken together with spectroscopic measurements of supersonic E × B rotation of sonic Mach 2, these measurements are in agreement with ideal MHD theory which predicts large parallel pressure drops balanced by centrifugal forces in supersonically rotating plasmas.

  6. Variations in depth-dose data between open and wedge fields for 4-MV x-rays

    International Nuclear Information System (INIS)

    Sewchand, W.; Khan, F.M.; Williamson, J.

    1978-01-01

    Central-axis depth-dose data for 4-MV x rays, including tissue-maximum ratios, were measured for wedge fields. Comparison with corresponding open-field data revealed differences in magnitude which increased with depth, field size, and wedge thickness. However, phantom scatter correction factors for the wedge fields differed less than 1% from corresponding open-field factors. The differences in central-axis percent depth doses between the two types of fields indicate beam hardening by the wedge filter. This study also implies that the derivation of tissue-maximum ratios from central-axis percent depth is as valid for wedge as for open fields

  7. One-loop masses of open-string scalar fields in string theory

    International Nuclear Information System (INIS)

    Kitazawa, Noriaki

    2008-01-01

    In phenomenological models with D-branes, there are in general open-string massless scalar fields, in addition to closed-string massless moduli fields corresponding to the compactification. It is interesting to focus on the fate of such scalar fields in models with broken supersymmetry, because no symmetry forbids their masses. The one-loop effect may give non-zero masses to them, and in some cases mass squared may become negative, which means the radiative gauge symmetry breaking. In this article we investigate and propose a simple method for calculating the one-loop corrections using the boundary state formalism. There are two categories of massless open-string scalar fields. One consists the gauge potential fields corresponding to compactified directions, which can be understood as scalar fields in uncompactified space-time (related with Wilson line degrees of freedom). The other consists 'gauge potential fields' corresponding to transverse directions of D-brane, which emerge as scalar fields in D-brane world-volume (related with brane moduli fields). The D-brane boundary states with constant backgrounds of these scalar fields are constructed, and one-loop scalar masses are calculated in the closed string picture. Explicit calculations are given in the following four concrete models: one D25-brane with a circle compactification in bosonic string theory, one D9-brane with a circle compactification in superstring theory, D3-branes at a supersymmetric C 3 /Z 3 orbifold singularity, and a model of brane supersymmetry breaking with D3-branes and anti-D7-branes at a supersymmetric C 3 /Z 3 orbifold singularity. We show that the sign of the mass squared has a strong correlation with the sign of the related open-string one-loop vacuum amplitude.

  8. Physical states at the tachyonic vacuum of open string field theory

    International Nuclear Information System (INIS)

    Giusto, S.; Imbimbo, C.

    2004-01-01

    We illustrate a method for computing the number of physical states of open string theory at the stable tachyonic vacuum in level truncation approximation. The method is based on the analysis of the gauge-fixed open string field theory quadratic action that includes Fadeev-Popov ghost string fields. Computations up to level 9 in the scalar sector are consistent with Sen's conjecture about the absence of physical open string states at the tachyonic vacuum. We also derive a long exact cohomology sequence that relates relative and absolute cohomologies of the BRS operator at the non-perturbative vacuum. We use this exact result in conjunction with our numerical findings to conclude that the higher ghost number non-perturbative BRS cohomologies are non-empty

  9. Open Wilson lines and generalized star product in noncommutative scalar field theories

    International Nuclear Information System (INIS)

    Kiem, Youngjai; Sato, Haru-Tada; Rey, Soo-Jong; Yee, Jung-Tay

    2002-01-01

    Open Wilson line operators and a generalized star product have been studied extensively in noncommutative gauge theories. We show that they also show up in noncommutative scalar field theories as universal structures. We first point out that the dipole picture of noncommutative geometry provides an intuitive argument for the robustness of the open Wilson lines and generalized star products therein. We calculate the one-loop effective action of noncommutative scalar field theory with a cubic self-interaction and show explicitly that the generalized star products arise in the nonplanar part. It is shown that, at the low-energy, large noncommutativity limit, the nonplanar part is expressible solely in terms of the scalar open Wilson line operator and descendants

  10. Field Trial of 40 Gb/s Optical Transport Network using Open WDM Interfaces

    DEFF Research Database (Denmark)

    Fagertun, Anna Manolova; Ruepp, Sarah Renée; Petersen, Martin Nordal

    2013-01-01

    An experimental field-trail deployment of a 40Gb/s open WDM interface in an operational network is presented, in cross-carrier interconnection scenario. Practical challenges of integration and performance measures for both native and alien channels are outlined....

  11. Automated TV based system for open field studies: Effects of methamphetamine

    NARCIS (Netherlands)

    Tanger, H.J.; Vanwersch, R.A.P.; Wolthuis, O.L.

    1978-01-01

    A method is described whereby open field behaviour of rats can be automatically registered using a TV camera, a video converter, an X-Y recorder and a papertape puncher. Use is made of the scanning properties of the TV camera to obtain the X and Y coordinates of the rat's position and to print this

  12. Peripubertal castration of male rats, adult open field ambulation and partner preference behavior.

    Science.gov (United States)

    Brand, T; Slob, A K

    1988-09-15

    The validity of the hypothesis put forward earlier, that testicular secretions during puberty have an organizing effect on open field ambulation was examined. Male rats were castrated or sham-operated at days 21, 43 or 70. At the age of 17 weeks the males were tested in an automated, octagonal open field (3 consecutive days, 3 min/day) for locomotor activity. Male rats castrated at day 21 or day 43 ambulated more than sham-castrated controls. Males castrated at day 70 did not differ from sham-castrated controls. It thus appears that pubertal testicular secretion(s) organize adult open field locomotor activity in male rats. From 18 weeks of age partner preference behavior was tested in the same open field apparatus with one adjacent cage containing an ovariectomized female and an opposite one containing an ovariectomized female brought into heat. The females in the adjacent cages were separated from the experimental males in the octagonal cage by wire mesh. Peripubertally castrated males did not show a clear-cut partner preference, whereas the intact males preferred the vicinity of the estrous female. There were no differences among the males castrated either before, during or after puberty. Testosterone treatment (crystalline T in silastic capsules) caused peripubertally castrated males to prefer the estrous female. Thus, adult partner preference behavior does not seem to be organized by peripubertal testicular androgens.

  13. Measurements and predictions of hooded crow (Corvus corone cornix) call propagation over open field habitats

    DEFF Research Database (Denmark)

    Jensen, Kenneth Kragh; Larsen, Ole Næsbye; Attenborough, Keith

    2008-01-01

    In a study of hooded crow communication over open fields an excellent correspondence is found between the attenuation spectra predicted by a "turbulence-modified ground effect plus atmospheric absorption" model, and crow call attenuation data. Sound propagation predictions and background noise...

  14. Field determination of multipollutant, open area combustion source emission factors with a hexacopter unmanned aerial vehicle

    Science.gov (United States)

    An emission sensor/sampler system was coupled to a NASA hexacopter unmanned aerial system (UAS) to characterize gases and particles in the plume emitted from open burning of military ordnance. The UAS/sampler was tested at two field sites resulting in 33 flights at Radford, VA a...

  15. Characteristics of growing media mixes and application for open-field production of strawberry (Fragaria ananassa)

    Science.gov (United States)

    Pathogen-free growing media are widely used for strawberry production in protected structures in Europe but not common in the United States. There is a need to investigate the feasibility of producing strawberry fruits in open fields with the pathogen-free media in the U.S. The objective of the stud...

  16. Heritability of feather pecking and open-field response of laying hens at two different ages

    NARCIS (Netherlands)

    Rodenburg, T.B.; Buitenhuis, A.J.; Ask, B.; Uitdehaag, K.A.; Koene, P.; Poel, van der J.J.; Bovenhuis, H.

    2003-01-01

    The objective of the current study was to estimate heritabilities. (h(2)) of feather pecking and open-field response of laying hens at two different ages. An F-2 cross, originating from a high and a low feather pecking line of laying hens, was used for the experiment. Each of the 630 birds of the

  17. Role of herbicide treatments and application times in cogongrass eradication under open field infestation scenario

    Science.gov (United States)

    A Cogongrass eradication project was conducted from spring 2008 through fall 2011 on natural, open-field Cogongrass infestations at two locations near Tilman's Corner and Bayou La Batre in southwestern Alabama. Treatments consisted of glyphosate alone (4 lb/acre), imazapyr alone (0.75 lb/acre) and ...

  18. Performance of Ductless Personalized Ventilation in Open-Plan Office - Field Survey

    DEFF Research Database (Denmark)

    Dalewski, Mariusz; Ezzat Khalifa, H.; Melikov, Arsen Krikor

    2013-01-01

    A field survey was conducted in an architectural company located in Syracuse, USA. 54 employees who participated in the survey performed mostly design work. Large open-plan office and several single offices ventilated by displacement air distribution were included in the survey. Ductless...

  19. Modeling and measuring sound propagation of hooded crow calls in open field habitats

    DEFF Research Database (Denmark)

    Jensen, Kenneth Kragh; Larsen, Ole Næsbye; Attenborough, Keith

    representative of crow territorial communication and taking into account ground effect and air turbulence, we predict an optimal transmission frequency range between 0,5-1.6 kHz. In a natural open field crow habitat we measure, with sender and receiver heights of 2.8 m and transmission distances up to 320 m...

  20. Exposure to a maternal cafeteria diet changes open-field behaviour in the developing offspring.

    Science.gov (United States)

    Speight, Abigail; Davey, William G; McKenna, Emily; Voigt, Jörg-Peter W

    2017-04-01

    The early postnatal period is a sensitive period in rodents as behavioural systems are developing and maturing during this time. However, little is currently known about the behavioural effects of feeding a hyper-energetic cafeteria diet (CD) during the lactational period when offspring behaviour is tested during early adolescence. To this end, 23days old offspring from dams (Wistar) fed on CD during lactation were tested in either the open-field or the elevated plus-maze for exploration and anxiety-related behaviour. On postnatal day 9, maternal behaviour and non-maternal behaviour of the dam was assessed. It was hypothesized that lactational CD feeding would reduce anxiety in the offspring. CD-fed dams had a higher energy intake, due to an overconsumption of sugars and fats. When offspring from these dams were exposed to the open field after weaning, their locomotor activity was increased. They entered the more aversive inner zone of the open-field after a shorter latency, made more entries into and spent more time in the inner zone. Anxiety-related behaviour was not affected upon exposure to the elevated plus maze, suggesting anxiolysis in the open-field only. Increased maternal licking/grooming behaviour could possibly contribute to the anxiolytic phenotype as observed in the offspring from the CD group. In conclusion, we demonstrate that lactational overfeeding impacts on the development of behaviour in the early adolescent rat. Copyright © 2016 ISDN. Published by Elsevier Ltd. All rights reserved.

  1. Social Effects on Rat Spatial Choice in an Open Field Task

    Science.gov (United States)

    Keller, Matthew R.; Brown, Michael F.

    2011-01-01

    Pairs of rats foraged in trials either together or separately in an open field apparatus for pellets hidden in discreet locations in a 5 x 5 matrix. Trial duration was either 1 or 4 min. The tendency to choose locations that had earlier been visited by another rat was examined by comparing the choices made in the presence and absence of the other…

  2. Ontogeny of open field activity in rats after neonatal lesioning of the mesocortical dopaminergic projection

    NARCIS (Netherlands)

    Kalsbeek, A.; de Bruin, J. P.; Matthijssen, M. A.; Uylings, H. B.

    1989-01-01

    In order to examine the effect of neonatal depletion of the dopaminergic mesocortical projection on the development of a prefrontal cortex-mediated behaviour the ontogeny of open field behaviour was studied after neonatal depletion of cortical dopamine. Cortical dopamine was depleted by neonatal

  3. Designing to bring the field to the showroom through open-ended provocation.

    NARCIS (Netherlands)

    Kelly, J.; Wensveen, S.A.G.

    2014-01-01

    Engaging formats are required to communicate designerly understandings of field studies to a broader audience within organisations. Here we present a case where the format of an exhibition, consisting of a collection of open-ended provocative design concepts, has been used to disseminate knowledge

  4. A handheld open-field infant keratometer (an american ophthalmological society thesis).

    Science.gov (United States)

    Miller, Joseph M

    2010-12-01

    To design and evaluate a new infant keratometer that incorporates an unobstructed view of the infant with both eyes (open-field design). The design of the open-field infant keratometer is presented, and details of its construction are given. The design incorporates a single-ring keratoscope for measurement of corneal astigmatism over a 4-mm region of the cornea and includes a rectangular grid target concentric within the ring to allow for the study of higher-order aberrations of the eye. In order to calibrate the lens and imaging system, a novel telecentric test object was constructed and used. The system was bench calibrated against steel ball bearings of known dimensions and evaluated for accuracy while being used in handheld mode in a group of 16 adult cooperative subjects. It was then evaluated for testability in a group of 10 infants and toddlers. Results indicate that while the device achieved the goal of creating an open-field instrument containing a single-ring keratoscope with a concentric grid array for the study of higher-order aberrations, additional work is required to establish better control of the vertex distance. The handheld open-field infant keratometer demonstrates testability suitable for the study of infant corneal astigmatism. Use of collimated light sources in future iterations of the design must be incorporated in order to achieve the accuracy required for clinical investigation.

  5. Antioxidant effects of nerolidol in mice hippocampus after open field test.

    Science.gov (United States)

    Nogueira Neto, José Damasceno; de Almeida, Antonia Amanda Cardoso; da Silva Oliveira, Johanssy; Dos Santos, Pauline Sousa; de Sousa, Damião Pergentino; de Freitas, Rivelilson Mendes

    2013-09-01

    The aim of this study was to evaluate the neuroprotective effects of nerolidol in mice hippocampus against oxidative stress in neuronal cells compared to ascorbic acid (positive control) as well as evaluated the nerolidol sedative effects by open field test compared to diazepam (positive control). Thirty minutes prior to behavioral observation on open field test, mice were intraperitoneally treated with vehicle, nerolidol (25, 50 and 75 mg/kg), diazepam (1 mg/kg) or ascorbic acid (250 mg/kg). To clarify the action mechanism of of nerolidol on oxidative stress in animals subjected to the open field test, Western blot analysis of Mn-superoxide dismutase and catalase in mice hippocampus were performed. In nerolidol group, there was a significant decrease in lipid peroxidation and nitrite levels when compared to negative control (vehicle). However, a significant increase was observed in superoxide dismutase and catalase activities in this group when compared to the other groups. Vehicle, diazepam, ascorbic acid and nerolidol groups did not affected Mn-superoxide dismutase, catalase mRNA or protein levels. Our findings strongly support the hypothesis that oxidative stress occurs in hippocampus. Nerolidol showed sedative effects in animals subjected to the open field test. Oxidative process plays a crucial role on neuronal pathological consequence, and implies that antioxidant effects could be achieved using this sesquiterpene.

  6. FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data

    NARCIS (Netherlands)

    Oostenveld, R.; Fries, P.; Maris, E.G.G.; Schoffelen, J.M.

    2011-01-01

    This paper describes FieldTrip, an open source software package that we developed for the analysis of MEG, EEG, and other electrophysiological data. The software is implemented as a MATLAB toolbox and includes a complete set of consistent and user-friendly high-level functions that allow

  7. A Human Open Field Test Reveals Thigmotaxis Related to Agoraphobic Fear.

    Science.gov (United States)

    Walz, Nora; Mühlberger, Andreas; Pauli, Paul

    2016-09-01

    Thigmotaxis refers to a specific behavior of animals (i.e., to stay close to walls when exploring an open space). Such behavior can be assessed with the open field test (OFT), which is a well-established indicator of animal fear. The detection of similar open field behavior in humans may verify the translational validity of this paradigm. Enhanced thigmotaxis related to anxiety may suggest the relevance of such behavior for anxiety disorders, especially agoraphobia. A global positioning system was used to analyze the behavior of 16 patients with agoraphobia and 18 healthy individuals with a risk for agoraphobia (i.e., high anxiety sensitivity) during a human OFT and compare it with appropriate control groups (n = 16 and n = 19). We also tracked 17 patients with agoraphobia and 17 control participants during a city walk that involved walking through an open market square. Our human OFT triggered thigmotaxis in participants; patients with agoraphobia and participants with high anxiety sensitivity exhibited enhanced thigmotaxis. This behavior was evident in increased movement lengths along the wall of the natural open field and fewer entries into the center of the field despite normal movement speed and length. Furthermore, participants avoided passing through the market square during the city walk, indicating again that thigmotaxis is related to agoraphobia. This study is the first to our knowledge to verify the translational validity of the OFT and to reveal that thigmotaxis, an evolutionarily adaptive behavior shown by most species, is related to agoraphobia, a pathologic fear of open spaces, and anxiety sensitivity, a risk factor for agoraphobia. Copyright © 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

  8. Quantitative assessment of the blood-brain barrier opening caused by Streptococcus agalactiae hyaluronidase in a BALB/c mouse model.

    Science.gov (United States)

    Luo, Su; Cao, Qing; Ma, Ke; Wang, Zhaofei; Liu, Guangjin; Lu, Chengping; Liu, Yongjie

    2017-10-19

    Streptococcus agalactiae is a pathogen causing meningitis in animals and humans. However, little is known about the entry of S. agalactiae into brain tissue. In this study, we developed a BALB/c mouse model based on the intravenous injection of β-galactosidase-positive Escherichia coli M5 as an indicator of blood-brain barrier (BBB) opening. Under physiological conditions, the BBB is impermeable to E. coli M5. In pathological conditions caused by S. agalactiae, E. coli M5 is capable of penetrating the brain through a disrupted BBB. The level of BBB opening can be assessed by quantitative measurement of E. coli M5 loads per gram of brain tissue. Further, we used the model to evaluate the role of S. agalactiae hyaluronidase in BBB opening. The inactivation of hylB gene encoding a hyaluronidase, HylB, resulted in significantly decreased E. coli M5 colonization, and the intravenous injection of purified HylB protein induced BBB opening in a dose-dependent manner. This finding verified the direct role of HylB in BBB invasion and traversal, and further demonstrated the practicability of the in vivo mouse model established in this study. This model will help to understand the S. agalactiae-host interactions that are involved in this bacterial traversal of the BBB and to develop efficacious strategies to prevent central nervous system infections.

  9. Exploratory behaviour in the open field test adapted for larval zebrafish: impact of environmental complexity.

    Science.gov (United States)

    Ahmad, Farooq; Richardson, Michael K

    2013-01-01

    This study aimed to develop and characterize a novel (standard) open field test adapted for larval zebrafish. We also developed and characterized a variant of the same assay consisting of a colour-enriched open field; this was used to assess the impact of environmental complexity on patterns of exploratory behaviours as well to determine natural colour preference/avoidance. We report the following main findings: (1) zebrafish larvae display characteristic patterns of exploratory behaviours in the standard open field, such as thigmotaxis/centre avoidance; (2) environmental complexity (i.e. presence of colours) differentially affects patterns of exploratory behaviours and greatly attenuates natural zone preference; (3) larvae displayed the ability to discriminate colours. As reported previously in adult zebrafish, larvae showed avoidance towards blue and black; however, in contrast to the reported adult behaviour, larvae displayed avoidance towards red. Avoidance towards yellow and preference for green and orange are shown for the first time, (4) compared to standard open field tests, exposure to the colour-enriched open field resulted in an enhanced expression of anxiety-like behaviours. To conclude, we not only developed and adapted a traditional rodent behavioural assay that serves as a gold standard in preclinical drug screening, but we also provide a version of the same test that affords the possibility to investigate the impact of environmental stress on behaviour in larval zebrafish while representing the first test for assessment of natural colour preference/avoidance in larval zebrafish. In the future, these assays will improve preclinical drug screening methodologies towards the goal to uncover novel drugs. This article is part of a Special Issue entitled: insert SI title. Copyright © 2012 Elsevier B.V. All rights reserved.

  10. On open and closed field line regions in Tsyganenko's field model and their possible associations with horse collar auroras

    International Nuclear Information System (INIS)

    Birn, J.; Hones, E.W. Jr.; Craven, J.D.; Frank, L.A.; Elphinstone, R.D.; Stern, D.P.

    1991-01-01

    Using the empirical Tsyganenko (1987) long model as a prime example of a megnetospheric field model, the authors have attempted to identify the boundary between open and closed field lines. They define as closed all field lines that are connested with the Earth at both ends and cross the equatorial plane earthward of x = -70 R E , the tailward validity limit of the Tsyganenko model. They find that the form of the open/closed boundary at the Earth's surface, identified with the polar cap boundary, can exhibit the arrowhead shape, pointed toward the Sun, observed in horse collar auroras (Hones et al., 1989). The polar cap size in the Tsyganenko model increases with increasing K p values, and it becomes rounder and less pointed. The superposition of a net B y field, which is the expected consequence of an IMF B y , rotates the polar cap pattern and, for larger values, degrades the arrowhead shape, resulting in polar cap configurations consistent with known asymmetries in the aurora. The pointedness of the polar cap shape also diminishes or even completely disappears if the low-latitude magnetopause is assumed open and located considerably inside of the outermost magnetic flux surface in the Tsyganenko model. The arrowhead shape of the polar cap is found to be associated with a strong increase of B z from midnight toward the tail flanks, which is observed independently, and is possibly related to the NBZ field-aligned current system, observed during quiet times and strongly northward IMF B z . The larger B z values near the flanks of the tail cause more magnetic flux to close through these regions than through the midnight equatorial region

  11. A simple solvable model of quantum field theory of open strings

    International Nuclear Information System (INIS)

    Kazakov, V.A.; AN SSSR, Moscow

    1990-01-01

    A model of quantum field theory of open strings without any embedding (D=0) is solved. The world sheets of interacting strings are represented by dynamical planar graphs with dynamical holes of arbitrary sizes. The phenomenon of spontaneous tearing of the world sheet is noticed, which gives a singularity at zero coupling constant of string interaction. This phenomenon can be considered as a nonperturbative effect, similar to renormalons in planar field theories and is closely related to the α' → 0 limit of string field theories. (orig.)

  12. Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open-angle glaucoma.

    Science.gov (United States)

    Zode, Gulab S; Bugge, Kevin E; Mohan, Kabhilan; Grozdanic, Sinisa D; Peters, Joseph C; Koehn, Demelza R; Anderson, Michael G; Kardon, Randy H; Stone, Edwin M; Sheffield, Val C

    2012-03-01

    Mutations in the myocilin gene (MYOC) are the most common known genetic cause of primary open-angle glaucoma (POAG). The purpose of this study was to determine whether topical ocular sodium 4-phenylbutyrate (PBA) treatment rescues glaucoma phenotypes in a mouse model of myocilin-associated glaucoma (Tg-MYOC(Y437H) mice). Tg-MYOC(Y437H) mice were treated with PBA eye drops (n = 10) or sterile PBS (n = 8) twice daily for 5 months. Long-term safety and effectiveness of topical PBA (0.2%) on glaucoma phenotypes were examined by measuring intraocular pressure (IOP) and pattern ERG (PERG), performing slit lamp evaluation of the anterior chamber, analyzing histologic sections of the anterior segment, and comparing myocilin levels in the aqueous humor and trabecular meshwork of Tg-MYOC(Y437H) mice. Tg-MYOC(Y437H) mice developed elevated IOP at 3 months of age when compared with wild-type (WT) littermates (n = 24; P < 0.0001). Topical PBA did not alter IOP in WT mice. However, it significantly reduced elevated IOP in Tg-MYOC(Y437H) mice to the level of WT mice. Topical PBA-treated Tg-MYOC(Y437H) mice also preserved PERG amplitudes compared with vehicle-treated Tg-MYOC(Y437H) mice. No structural abnormalities were observed in the anterior chamber of PBA-treated WT and Tg-MYOC(Y437H) mice. Analysis of the myocilin in the aqueous humor and TM revealed that PBA significantly improved the secretion of myocilin and reduced myocilin accumulation as well as endoplasmic reticulum (ER) stress in the TM of Tg-MYOC(Y437H) mice. Furthermore, topical PBA reduced IOP elevated by induction of ER stress via tunicamycin injections in WT mice. Topical ocular PBA reduces glaucomatous phenotypes in Tg-MYOC(Y437H) mice, most likely by reducing myocilin accumulation and ER stress in the TM. Topical ocular PBA could become a novel treatment for POAG patients with myocilin mutations.

  13. Identifying a cooperative control mechanism between an applied field and the environment of open quantum systems

    Science.gov (United States)

    Gao, Fang; Rey-de-Castro, Roberto; Wang, Yaoxiong; Rabitz, Herschel; Shuang, Feng

    2016-05-01

    Many systems under control with an applied field also interact with the surrounding environment. Understanding the control mechanisms has remained a challenge, especially the role played by the interaction between the field and the environment. In order to address this need, here we expand the scope of the Hamiltonian-encoding and observable-decoding (HE-OD) technique. HE-OD was originally introduced as a theoretical and experimental tool for revealing the mechanism induced by control fields in closed quantum systems. The results of open-system HE-OD analysis presented here provide quantitative mechanistic insights into the roles played by a Markovian environment. Two model open quantum systems are considered for illustration. In these systems, transitions are induced by either an applied field linked to a dipole operator or Lindblad operators coupled to the system. For modest control yields, the HE-OD results clearly show distinct cooperation between the dynamics induced by the optimal field and the environment. Although the HE-OD methodology introduced here is considered in simulations, it has an analogous direct experimental formulation, which we suggest may be applied to open systems in the laboratory to reveal mechanistic insights.

  14. Singular surfaces in the open field line region of a diverted tokamak

    International Nuclear Information System (INIS)

    Reiman, A.

    1996-01-01

    The structure of the open field lines of a slightly nonaxisymmetric, poloidally diverted tokamak is explored by numerical integration of the field line equations for a simple model field. In practice, the nonaxisymmetry could be produced self-consistently by the nonlinear evolution of a free-boundary magnetohydrodynamic (MHD) mode, or it could be produced by field errors, or it could be imposed externally by design. In the presence of a nonaxisymmetric perturbation, the tokamak is shown to develop open field line regions of differing topology separated by singular surfaces. It is argued that the singular surfaces can be expected to play a role analogous to that of rational toroidal flux surfaces, in terms of constraining ideal MHD perturbations and thus constraining the free-energy that can be tapped by ideal MHD instabilities. The possibility of active control of free-boundary instabilities by means of currents driven on the open singular surfaces, which are directly accessible from the divertor plates, is discussed. copyright 1996 American Institute of Physics

  15. Singular surfaces in the open field line region of a diverted tokamak

    International Nuclear Information System (INIS)

    Reiman, A.

    1995-05-01

    The structure of the open field lines of a slightly nonaxisymmetric, poloidally diverted tokamak is explored by numerical integration of the field line equations for a simple model field. In practice, the nonaxisymmetry could be produced self-consistently by the nonlinear evolution of a free-boundary MHD mode, or it could be produced by field errors, or it could be imposed externally by design. In the presence of a nonaxisymmetric perturbation, the tokamak is shown to develop open field line regions of differing topology separated by singular surfaces. It is argued that the singular surfaces can be expected to play a role analogous to that of rational toroidal flux surfaces, in terms of constraining ideal MHD perturbations and thus constraining the free-energy that can be tapped by ideal MHD instabilities. The possibility of active control of free-boundary instabilities by means of currents driven on the open singular surfaces, which are directly accessible from the divertor plates, is discussed. Also discussed is the possibility of early detection of imminent disruptions through localized measurement of the singular surface currents

  16. Real analytic solutions for marginal deformations in open superstring field theory

    International Nuclear Information System (INIS)

    Okawa, Yuji

    2007-01-01

    We construct analytic solutions for marginal deformations satisfying the reality condition in open superstring field theory formulated by Berkovits when operator products made of the marginal operator and the associated superconformal primary field are regular. Our strategy is based on the recent observation by Erler that the problem of finding solutions for marginal deformations in open superstring field theory can be reduced to a problem in the bosonic theory of finding a finite gauge parameter for a certain pure-gauge configuration labeled by the parameter of the marginal deformation. We find a gauge transformation generated by a real gauge parameter which infinitesimally changes the deformation parameter and construct a finite gauge parameter by its path-ordered exponential. The resulting solution satisfies the reality condition by construction

  17. Real analytic solutions for marginal deformations in open superstring field theory

    International Nuclear Information System (INIS)

    Okawa, Y.

    2007-04-01

    We construct analytic solutions for marginal deformations satisfying the reality condition in open superstring field theory formulated by Berkovits when operator products made of the marginal operator and the associated superconformal primary field are regular. Our strategy is based on the recent observation by Erler that the problem of finding solutions for marginal deformations in open superstring field theory can be reduced to a problem in the bosonic theory of finding a finite gauge parameter for a certain pure-gauge configuration labeled by the parameter of the marginal deformation. We find a gauge transformation generated by a real gauge parameter which infinitesimally changes the deformation parameter and construct a finite gauge parameter by its path-ordered exponential. The resulting solution satisfies the reality condition by construction. (orig.)

  18. Response Properties of a Newly Identified Tristratified Narrow Field Amacrine Cell in the Mouse Retina.

    Directory of Open Access Journals (Sweden)

    G S Newkirk

    Full Text Available Amacrine cells were targeted for whole cell recording using two-photon fluorescence microscopy in a transgenic mouse line in which the promoter for dopamine receptor 2 drove expression of green fluorescent protein in a narrow field tristratified amacrine cell (TNAC that had not been studied previously. Light evoked a multiphasic response that was the sum of hyperpolarizing and depolarization synaptic inputs consistent with distinct dendritic ramifications in the off and on sublamina of the inner plexiform layer. The amplitude and waveform of the response, which consisted of an initial brief hyperpolarization at light onset followed by recovery to a plateau potential close to dark resting potential and a hyperpolarizing response at the light offset varied little over an intensity range from 0.4 to ~10^6 Rh*/rod/s. This suggests that the cell functions as a differentiator that generates an output signal (a transient reduction in inhibitory input to downstream retina neurons that is proportional to the derivative of light input independent of its intensity. The underlying circuitry appears to consist of rod and cone driven on and off bipolar cells that provide direct excitatory input to the cell as well as to GABAergic amacrine cells that are synaptically coupled to TNAC. Canonical reagents that blocked excitatory (glutamatergic and inhibitory (GABA and glycine synaptic transmission had effects on responses to scotopic stimuli consistent with the rod driven component of the proposed circuit. However, responses evoked by photopic stimuli were paradoxical and could not be interpreted on the basis of conventional thinking about the neuropharmacology of synaptic interactions in the retina.

  19. Widening access through openness in higher education in the developing world: A Bourdieusian field analysis of experiences from the National Open University of Nigeria

    Directory of Open Access Journals (Sweden)

    Felix Kayode Olakulehin

    2013-01-01

    Full Text Available Bourdieu has argued that higher education is a field that reproduces social inequality, thus complicating how openness widens access to higher education in the developing world. Drawing on the experiences of the National Open University of Nigeria (NOUN, this paper critically analyses and evaluates the rationale, approach, difficulties, opportunities, outcomes and benefits of NOUN’s experience in widening access to higher education in Nigeria using Bourdieu’s field theory. We argue that the success of efforts for openness in higher education in a developing world context involves steering the contradictory tensions of openness and access across competing policy and practice fields. We offer this theorisation as a future social theoretical agenda for reflexive research for improving the effectiveness of praxis to widen access through openness in higher education in the developing world.

  20. Magnetic field effects on the open circuit potential of ferromagnetic electrodes in corroding solutions.

    Science.gov (United States)

    Dass, Amala; Counsil, Joseph A; Gao, Xuerong; Leventis, Nicholas

    2005-06-02

    Magnetic fields shift the open circuit potential (OCP) of ferromagnetic electrodes (Fe, Co, and Ni) in corroding solutions. The OCP changes we observe (a) follow the series Fe>Co>Ni; (b) increase with the magnetic flux density; (c) reach a maximum with disk electrodes approximately 1 mm in diameter; and (d) depend on the orientation of the electrode. We report that when the surface of the electrode is oriented parallel (theta = 90 degrees) or perpendicular (theta = 0 degrees) to the magnetic field, the open circuit potential moves in opposite directions (positive and negative, respectively) with the largest changes occurring when the electrode surface is parallel to the magnetic field. Nonconvective sleeve electrodes produce the same behavior. The overall experimental evidence suggests that the magnetic field changes the OCP by modifying the surface concentrations of the paramagnetic participants in the corrosion process of the ferromagnetic electrode by species in solution; this in turn is accomplished by imposing a field-gradient driven mode of mass transfer upon paramagnetic species in solution (magnetophoresis). Simulations of the magnetic field around the ferromagnetic electrode at the two extreme orientations considered here show that in one case (theta = 90 degrees) field gradients actually repel, while in the other case (theta = 0 degrees) they attract paramagnetic species in the vicinity of the electrode.

  1. Chemical Concentrations in Field Mice from Open-Detonation Firing Sites TA-36 Minie and TA-39 Point 6 at Los Alamos National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Fresquez, Philip R. [Los Alamos National Laboratory

    2011-01-01

    Field mice (mostly Peromyscus spp.) were collected at two open-detonation (high explosive) firing sites - Minie at Technical Area (TA) 36 and Point 6 at TA-39 - at Los Alamos National Laboratory in August of 2010 and in February of 2011 for chemical analysis. Samples of whole body field mice from both sites were analyzed for target analyte list elements (mostly metals), dioxin/furans, polychlorinated biphenyl congeners, high explosives, and perchlorate. In addition, uranium isotopes were analyzed in a composite sample collected from TA-36 Minie. In general, all constituents, with the exception of lead at TA-39 Point 6, in whole body field mice samples collected from these two open-detonation firing sites were either not detected or they were detected below regional statistical reference levels (99% confidence level), biota dose screening levels, and/or soil ecological chemical screening levels. The amount of lead in field mice tissue collected from TA-39 Point 6 was higher than regional background, and some lead levels in the soil were higher than the ecological screening level for the field mouse; however, these levels are not expected to affect the viability of the populations over the site as a whole.

  2. Evidence-based severity assessment: Impact of repeated versus single open-field testing on welfare in C57BL/6J mice.

    Science.gov (United States)

    Bodden, Carina; Siestrup, Sophie; Palme, Rupert; Kaiser, Sylvia; Sachser, Norbert; Richter, S Helene

    2018-01-15

    According to current guidelines on animal experiments, a prospective assessment of the severity of each procedure is mandatory. However, so far, the classification of procedures into different severity categories mainly relies on theoretic considerations, since it is not entirely clear which of the various procedures compromise the welfare of animals, or, to what extent. Against this background, a systematic empirical investigation of the impact of each procedure, including behavioral testing, seems essential. Therefore, the present study was designed to elucidate the effects of repeated versus single testing on mouse welfare, using one of the most commonly used paradigms for behavioral phenotyping in behavioral neuroscience, the open-field test. In an independent groups design, laboratory mice (Mus musculus f. domestica) experienced either repeated, single, or no open-field testing - procedures that are assigned to different severity categories. Interestingly, testing experiences did not affect fecal corticosterone metabolites, body weights, elevated plus-maze or home cage behavior differentially. Thus, with respect to the assessed endocrinological, physical, and behavioral outcome measures, no signs of compromised welfare could be detected in mice that were tested in the open-field repeatedly, once, or, not at all. These findings challenge current classification guidelines and may, furthermore, stimulate systematic research on the severity of single procedures involving living animals. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Standardized UXO Technology Demonstration Site, Open Field Scoring Record No. 770. Magnetometer FEREX DLG GPS/Sling

    National Research Council Canada - National Science Library

    Karwatka, Mike; Packer, Bonnie

    2006-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site open field. Scoring Records have been coordinated by Mike Karwatka and the Standardized UXO Technology Demonstration Site Scoring Committee...

  4. Widening Access through Openness in Higher Education in the Developing World: A Bourdieusian Field Analysis of Experiences from the National Open University of Nigeria

    Science.gov (United States)

    Olakulehin, Felix Kayode; Singh, Gurmit

    2013-01-01

    Bourdieu has argued that higher education is a field that reproduces social inequality, thus complicating how openness widens access to higher education in the developing world. Drawing on the experiences of the National Open University of Nigeria (NOUN), this paper critically analyses and evaluates the rationale, approach, difficulties,…

  5. Probing two-field open inflation by resonant signals in correlation functions

    Energy Technology Data Exchange (ETDEWEB)

    Battefeld, Thorsten; Niemeyer, Jens C.; Vlaykov, Dimitar, E-mail: tbattefe@astro.physik.uni-goettingen.de, E-mail: niemeyer@astro.physik.uni-goettingen.de, E-mail: vlaykov@astro.physik.uni-goettingen.de [Institute for Astrophysics, University of Goettingen, Friedrich Hund Platz 1, D-37077 Goettingen (Germany)

    2013-05-01

    We derive oscillatory signals in correlation functions in two-field open inflation by means of the in-in formalism; such signatures are caused by resonances between oscillations in the tunnelling field and fluctuations in the inflaton during the curvature dominated, intermediate and subsequent inflationary regime. While amplitudes are model-dependent, we find distinct oscillations in the power and bi-spectrum that can act as a direct probe of the curvature dominated phase and thus, indirectly, strengthen the claim of the string landscape if they were observed. We comment on the prospects of detecting these tell-tale signs in current experiments, which is challenging, but not impossible. At the technical level, we pay special attention to the applicability conditions for truncating fluctuations to the light (inflaton) field and derive upper limits on the oscillation amplitude of the heavy field. A violation of these bounds requires a multi-field analysis at the perturbed level.

  6. A model of the open magnetosphere. [with field configuration based on Chapman-Ferraro theory

    Science.gov (United States)

    Kan, J. R.; Akasofu, S.-I.

    1974-01-01

    The Chapman-Ferraro image method is extended to construct an idealized model of the open magnetosphere that responds to a change of the interplanetary field direction as well as to a change of the field magnitude or of the solar wind momentum flux. The magnetopause of the present model is an infinite plane surface having a normal field component distribution that is consistent with the merging theory. An upper limit on the inward displacement of the magnetopause following a southward turning of the interplanetary field is obtained. The results are in fair agreement with a single event reported by Aubry et al. (1971). The model determines the field configuration and the total magnetic flux connecting the magnetosphere to interplanetary space.

  7. Quinolone and glycopeptide therapy for infection in mouse following exposure to mixed-field neutron-γ-photon radiation

    International Nuclear Information System (INIS)

    Brook, I.; Tom, S.P.; Ledney, G.D.

    1993-01-01

    The effects of increased doses of mixed-field neutron-γ-photon irradiation on bacterial translocation and subsequent sepsis, and the influence of antimicrobial therapy on these events, were studied in the C3H/HeN mouse. The results demonstrate a relationship between the doses of mixed-field radiation and the rates of infection due to Enterobacteriaceae. While L-ofloxacin therapy reduces the infection rate, prolongs survival and prevents mortality, the addition of a glycopeptide can enhance systemic infection by resistant bacteria in the irradiated host. (author)

  8. Quinolone and glycopeptide therapy for infection in mouse following exposure to mixed-field neutron-[gamma]-photon radiation

    Energy Technology Data Exchange (ETDEWEB)

    Brook, I. (Naval Medical Research Inst., Bethesda, MD (United States) Armed Forces Radiobiology Research Inst., Bethesda, MD (United States)); Tom, S.P.; Ledney, G.D. (Armed Forces Radiobiology Research Inst., Bethesda, MD (United States))

    1993-12-01

    The effects of increased doses of mixed-field neutron-[gamma]-photon irradiation on bacterial translocation and subsequent sepsis, and the influence of antimicrobial therapy on these events, were studied in the C3H/HeN mouse. The results demonstrate a relationship between the doses of mixed-field radiation and the rates of infection due to Enterobacteriaceae. While L-ofloxacin therapy reduces the infection rate, prolongs survival and prevents mortality, the addition of a glycopeptide can enhance systemic infection by resistant bacteria in the irradiated host. (author).

  9. Oxygen plasma assisted end-opening and field emission enhancement in vertically aligned multiwall carbon nanotubes

    International Nuclear Information System (INIS)

    Mathur, A.; Roy, S.S.; Hazra, K.S.; Wadhwa, S.; Ray, S.C.; Mitra, S.K.; Misra, D.S.; McLaughlin, J.A.

    2012-01-01

    Highlights: ► We showed Ar/O 2 plasma can be effective for the end opening of aligned CNTs. ► The field emission property was dramatically enhanced after plasma modification. ► Microstructures were clearly understood by Raman and SEM analysis. ► Surface wet-ability at various functionalised conditions was studied. - Abstract: This paper highlights the changes in micro-structural and field emission properties of vertically aligned carbon nanotubes (VACNTs) via oxygen plasma treatment. We find that exposure of very low power oxygen plasma (6 W) at 13.56 MHz for 15–20 min, opens the tip of vertically aligned CNTs. Scanning electron microscopy and transmission electron microscopy images were used to identify the quality and micro-structural changes of the nanotube morphology and surfaces. Raman spectra showed that the numbers of defects were increased throughout the oxygen plasma treatment process. In addition, the hydrophobic nature of the VACNTs is altered significantly and the contact angle decreases drastically from 110° to 40°. It was observed that the electron field emission (EFE) characteristics are significantly enhanced. The turn-on electric field (ETOE) of CNTs decreased from ∼0.80 V μm −1 (untreated) to ∼0.60 V μm −1 (oxygen treated). We believe that the open ended VACNTs would be immensely valuable for applications such as micro/nanofluidic based filtering elements and display devices.

  10. Identifying open magnetic field regions of the Sun and their heliospheric counterparts

    Science.gov (United States)

    Krista, L. D.; Reinard, A.

    2017-12-01

    Open magnetic regions on the Sun are either long-lived (coronal holes) or transient (dimmings) in nature. Both phenomena are fundamental to our understanding of the solar behavior as a whole. Coronal holes are the sources of high-speed solar wind streams that cause recurrent geomagnetic storms. Furthermore, the variation of coronal hole properties (area, location, magnetic field strength) over the solar activity cycle is an important marker of the global evolution of the solar magnetic field. Dimming regions, on the other hand, are short-lived coronal holes that often emerge in the wake of solar eruptions. By analyzing their physical properties and their temporal evolution, we aim to understand their connection with their eruptive counterparts (flares and coronal mass ejections) and predict the possibility of a geomagnetic storm. The author developed the Coronal Hole Automated Recognition and Monitoring (CHARM) and the Coronal Dimming Tracker (CoDiT) algorithms. These tools not only identify but track the evolution of open magnetic field regions. CHARM also provides daily coronal hole maps, that are used for forecasts at the NOAA Space Weather Prediction Center. Our goal is to better understand the processes that give rise to eruptive and non-eruptive open field regions and investigate how these regions evolve over time and influence space weather.

  11. Emotionality in growing pigs: is the open field a valid test?

    Science.gov (United States)

    Donald, Ramona D; Healy, Susan D; Lawrence, Alistair B; Rutherford, Kenneth M D

    2011-10-24

    The ability to assess emotionality is important within animal welfare research. Yet, for farm animals, few tests of emotionality have been well validated. Here we investigated the construct validity of behavioural measures of pig emotionality in an open-field test by manipulating the experiences of pigs in three ways. In Experiment One (pharmacological manipulation), pigs pre-treated with Azaperone, a drug used to reduce stress in commercial pigs, were more active, spent more time exploring and vocalised less than control pigs. In Experiment Two (social manipulation), pigs that experienced the open-field arena with a familiar companion were also more exploratory, spent less time behaviourally idle, and were less vocal than controls although to a lesser degree than in Experiment One. In Experiment Three (novelty manipulation), pigs experiencing the open field for a second time were less active, explored less and vocalised less than they had done in the first exposure to the arena. A principal component analysis was conducted on data from all three trials. The first two components could be interpreted as relating to the form (cautious to exploratory) and magnitude (low to high arousal) of the emotional response to open-field testing. Based on these dimensions, in Experiment One, Azaperone pigs appeared to be less fearful than saline-treated controls. However, in Experiment Two, exposure to the arena with a conspecific did not affect the first two dimensions but did affect a third behavioural dimension, relating to oro-nasal exploration of the arena floor. In Experiment Three, repeat exposure altered the form but not the magnitude of emotional response: pigs were less exploratory in the second test. In conclusion, behavioural measures taken from pigs in an open-field test are sensitive to manipulations of their prior experience in a manner that suggests they reflect underlying emotionality. Behavioural measures taken during open-field exposure can be useful for making

  12. Piranti Lunak Pengujian Struktur Matematika Grup, Ring, Field Berbasis Osp (Open Source Program

    Directory of Open Access Journals (Sweden)

    Ngarap Im Manik

    2014-06-01

    Full Text Available This design of a computer software is a development and continuation of the software made on the previous research (2009/2010. However, this further research developed and expanded the scopes of testing more on the Siclic Group, Isomorphism Group, Semi Group, Sub Group and Abelian Group, Factor Ring, Sub Ring and Polynomial Ring; developed on the OSP (Open Source Program-based. The software was developed using the OSP-based language programming, such Java, so it is open and free to use for its users. This research succeeded to develop an open source software of Java program that can be used for testing specific mathematical Groups, such Ciclic Group, Isomorphism Group, Semi Group, Sub Group and Abelian Group, and Rings, Commutative Ring, Division Ring, Ideal Sub Ring, Ring Homomorphism, Ring Epimorphism and Fields. By the results, the software developed was able to test as same as the results from manual testing.

  13. Oval gradient coils for an open magnetic resonance imaging system with a vertical magnetic field.

    Science.gov (United States)

    Matsuzawa, Koki; Abe, Mitsushi; Kose, Katsumi; Terada, Yasuhiko

    2017-05-01

    Existing open magnetic resonance imaging (MRI) systems use biplanar gradient coils for the spatial encoding of signals. We propose using novel oval gradient coils for an open vertical-field MRI. We designed oval gradients for a 0.3T open MRI system and showed that such a system could outperform a traditional biplanar gradient system while maintaining adequate gradient homogeneity and subject accessibility. Such oval gradient coils would exhibit high efficiency, low inductance and resistance, and high switching capability. Although the designed oval Y and Z coils showed more heat dissipation and less cooling capability than biplanar coils with the same gap, they showed an efficient heat-dissipation path to the surrounding air, which would alleviate the heat problem. The performance of the designed oval-coil system was demonstrated experimentally by imaging a human hand. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Opening

    International Nuclear Information System (INIS)

    Grimstad, Erlend

    1999-01-01

    The views of the Norwegian Government on oil and gas issues are presented. Today Norwegian deliveries of natural gas account for a substantial and growing part of the supplies of gas to Europe. The Government has always tried to implement rules and regulations, which encourage the efficient exploitation of the petroleum resources. The two pillars of the gas marketing system are negotiation of non-field specific gas supply contracts and government allocation of these contracts to individual fields. The Gas Supply Committee is established to make recommendations on allocation issues. Many gas fields on the Continental Shelf have large portions of oil and condensate attached to the gas production. These fields can be produced more efficiently. In Norway, natural gas is gradually becoming a more important part of the Norwegian petroleum activities, and the potential gas resources are expected to be of the same order as the expected potential oil resources. In the present situation, injection gas is needed to optimize the oil production and this imposes constraints on new exports of natural gas. The overall goals of the petroleum industry were reported to the parliament in 1998. In 1999 a supplementary report was presented that covers (1) The oil market and Norwegian policy, (2) The competitiveness of the Norwegian Shelf, (3) The Investment Panel's report which analyzes cost overruns for recent petroleum development projects, and (4) A specific report on cost increases in the Aasgard project. These items are discussed in some detail

  15. Opening

    Energy Technology Data Exchange (ETDEWEB)

    Grimstad, Erlend [Olje- og energidepartementet, Oslo (Norway)

    1999-07-01

    The views of the Norwegian Government on oil and gas issues are presented. Today Norwegian deliveries of natural gas account for a substantial and growing part of the supplies of gas to Europe. The Government has always tried to implement rules and regulations, which encourage the efficient exploitation of the petroleum resources. The two pillars of the gas marketing system are negotiation of non-field specific gas supply contracts and government allocation of these contracts to individual fields. The Gas Supply Committee is established to make recommendations on allocation issues. Many gas fields on the Continental Shelf have large portions of oil and condensate attached to the gas production. These fields can be produced more efficiently. In Norway, natural gas is gradually becoming a more important part of the Norwegian petroleum activities, and the potential gas resources are expected to be of the same order as the expected potential oil resources. In the present situation, injection gas is needed to optimize the oil production and this imposes constraints on new exports of natural gas. The overall goals of the petroleum industry were reported to the parliament in 1998. In 1999 a supplementary report was presented that covers (1) The oil market and Norwegian policy, (2) The competitiveness of the Norwegian Shelf, (3) The Investment Panel's report which analyzes cost overruns for recent petroleum development projects, and (4) A specific report on cost increases in the Aasgard project. These items are discussed in some detail.

  16. GROWTH AND PRODUCTION OF KIWANO IN THE OPEN FIELD IN THE SOUTH OF WESTERN SIBERIA

    Directory of Open Access Journals (Sweden)

    N. B. Naumova

    2016-01-01

    Full Text Available Kiwano plants, or horned cucumber (Cucumis metuliferus E. Mey ex Naudin was grown in the open field in several experimental plots in the south of West Siberia (54,95025 N, 83,09763 E. Fruits production was correlated with night air temperature sum and soil organic matter content, reaching the maximum of 2.7 kg (fresh phytomass per plant. Fruit size and some basic juice characteristics were similar to those of kiwano fruits grown elsewhere in the world. The vegetative phytomass grown was correlated with day air temperature sum, being practically independent of soil chemical properties. Thus kiwano can be recommended as a crop to be grown in the open field in the south of West Siberia and other regions of Russia with similar soil and environmental conditions.

  17. Finasteride inhibited brain dopaminergic system and open-field behaviors in adolescent male rats.

    Science.gov (United States)

    Li, Li; Kang, Yun-Xiao; Ji, Xiao-Ming; Li, Ying-Kun; Li, Shuang-Cheng; Zhang, Xiang-Jian; Cui, Hui-Xian; Shi, Ge-Ming

    2018-02-01

    Finasteride inhibits the conversion of testosterone to dihydrotestosterone. Because androgen regulates dopaminergic system in the brain, it could be hypothesized that finasteride may inhibit dopaminergic system. The present study therefore investigates the effects of finasteride in adolescent and early developmental rats on dopaminergic system, including contents of dopamine and its metabolites (dihydroxy phenyl acetic acid and homovanillic acid) and tyrosine hydroxylase expressions both at gene and protein levels. Meanwhile, open-field behaviors of the rats are examined because of the regulatory effect of dopaminergic system on the behaviors. Open-field behaviors were evaluated by exploratory and motor behaviors. Dopamine and its metabolites were assayed by liquid chromatography-mass spectrometry. Tyrosine hydroxylase mRNA and protein expressions were determined by real-time qRT-PCR and western blot, respectively. It was found that in adolescent male rats, administration of finasteride at doses of 25 and 50 mg/kg for 14 days dose dependently inhibited open-field behaviors, reduced contents of dopamine and its metabolites in frontal cortex, hippocampus, caudate putamen, nucleus accumbens, and down-regulated tyrosine hydroxylase mRNA and protein expressions in substantia nigra and ventral tegmental area. However, there was no significant change of these parameters in early developmental rats after finasteride treatment. These results suggest that finasteride inhibits dopaminergic system and open-field behaviors in adolescent male rats by inhibiting the conversion of testosterone to dihydrotestosterone, and imply finasteride as a potential therapeutic option for neuropsychiatric disorders associated with hyperactivities of dopaminergic system and androgen. © 2017 John Wiley & Sons Ltd.

  18. The effect of a defective BSF layer on solar cell open circuit voltage. [Back Surface Field

    Science.gov (United States)

    Weizer, V. G.

    1985-01-01

    A straightforward analysis of special limiting cases has permitted the determination of the range of possible open circuit voltage losses due to a defective BSF (back surface field) layer. An important result of the analysis is the finding that it is possible to have a fully effective BSF region, regardless of the spatial distribution of the defective areas, as long as the total defective area is reduced below certain limits. Distributed defects were found to be much more harmful than lumped defects.

  19. Chronic Toxoplasma gondii in Nurr1-null heterozygous mice exacerbates elevated open field activity.

    Science.gov (United States)

    Eells, Jeffrey B; Varela-Stokes, Andrea; Guo-Ross, Shirley X; Kummari, Evangel; Smith, Holly M; Cox, Erin; Lindsay, David S

    2015-01-01

    Latent infection with Toxoplasma gondii is common in humans (approximately 30% of the global population) and is a significant risk factor for schizophrenia. Since prevalence of T. gondii infection is far greater than prevalence of schizophrenia (0.5-1%), genetic risk factors are likely also necessary to contribute to schizophrenia. To test this concept in an animal model, Nurr1-null heterozygous (+/-) mice and wild-type (+/+) mice were evaluate using an emergence test, activity in an open field and with a novel object, response to bobcat urine and prepulse inhibition of the acoustic startle response (PPI) prior to and 6 weeks after infection with T. gondii. In the emergence test, T. gondii infection significantly decreased the amount of time spent in the cylinder. Toxoplasma gondii infection significantly elevated open field activity in both +/+ and +/- mice but this increase was significantly exacerbated in +/- mice. T. gondii infection reduced PPI in male +/- mice but this was not statistically significant. Aversion to bobcat urine was abolished by T. gondii infection in +/+ mice. In female +/- mice, aversion to bobcat urine remained after T. gondii infection while the male +/- mice showed no aversion to bobcat urine. Antibody titers of infected mice were a critical variable associated with changes in open field activity, such that an inverted U shaped relationship existed between antibody titers and the percent change in open field activity with a significant increase in activity at low and medium antibody titers but no effect at high antibody titers. These data demonstrate that the Nurr1 +/- genotype predisposes mice to T. gondii-induced alterations in behaviors that involve dopamine neurotransmission and are associated with symptoms of schizophrenia. We propose that these alterations in murine behavior were due to further exacerbation of the altered dopamine neurotransmission in Nurr1 +/- mice.

  20. Energetic electron anisotropies in the magnetotail - Identification of open and closed field lines

    Science.gov (United States)

    Baker, D. N.; Stone, E. C.

    1976-01-01

    Unidirectional anisotropies in the energetic electron fluxes (E greater than or equal to about 200 keV) have been observed in the earth's magnetotail with the Caltech Electron/Isotope Spectrometer on IMP-8. The anisotropies occur during periods of enhanced fluxes and provide essential information on the topology (open or closed) of the magnetotail field lines which are associated with recently identified acceleration regions.

  1. Chronic Toxoplasma gondii in Nurr1-null heterozygous mice exacerbates elevated open field activity.

    Directory of Open Access Journals (Sweden)

    Jeffrey B Eells

    Full Text Available Latent infection with Toxoplasma gondii is common in humans (approximately 30% of the global population and is a significant risk factor for schizophrenia. Since prevalence of T. gondii infection is far greater than prevalence of schizophrenia (0.5-1%, genetic risk factors are likely also necessary to contribute to schizophrenia. To test this concept in an animal model, Nurr1-null heterozygous (+/- mice and wild-type (+/+ mice were evaluate using an emergence test, activity in an open field and with a novel object, response to bobcat urine and prepulse inhibition of the acoustic startle response (PPI prior to and 6 weeks after infection with T. gondii. In the emergence test, T. gondii infection significantly decreased the amount of time spent in the cylinder. Toxoplasma gondii infection significantly elevated open field activity in both +/+ and +/- mice but this increase was significantly exacerbated in +/- mice. T. gondii infection reduced PPI in male +/- mice but this was not statistically significant. Aversion to bobcat urine was abolished by T. gondii infection in +/+ mice. In female +/- mice, aversion to bobcat urine remained after T. gondii infection while the male +/- mice showed no aversion to bobcat urine. Antibody titers of infected mice were a critical variable associated with changes in open field activity, such that an inverted U shaped relationship existed between antibody titers and the percent change in open field activity with a significant increase in activity at low and medium antibody titers but no effect at high antibody titers. These data demonstrate that the Nurr1 +/- genotype predisposes mice to T. gondii-induced alterations in behaviors that involve dopamine neurotransmission and are associated with symptoms of schizophrenia. We propose that these alterations in murine behavior were due to further exacerbation of the altered dopamine neurotransmission in Nurr1 +/- mice.

  2. Management of whitefly-transmitted viruses in open-field production systems.

    Science.gov (United States)

    Lapidot, Moshe; Legg, James P; Wintermantel, William M; Polston, Jane E

    2014-01-01

    Whiteflies are a key pest of crops in open-field production throughout the tropics and subtropics. This is due in large part to the long and diverse list of devastating plant viruses transmitted by these vectors. Open-field production provides many challenges to manage these viruses and in many cases adequate management has not been possible. Diseases caused by whitefly-transmitted viruses have become limiting factors in open-field production of a wide range of crops, i.e., bean golden mosaic disease in beans, tomato yellow leaf curl disease in tomato, cassava mosaic disease and cassava brown streak disease in cassava, and cotton leaf crumple disease in cotton. While host resistance has proven to be the most cost-effective management solution, few examples of host resistance have been developed to date. The main strategy to limit the incidence of virus-infected plants has been the application of insecticides to reduce vector populations aided to some extent by the use of selected cultural practices. However, due to concerns about the effect of insecticides on pollinators, consumer demand for reduced pesticide use, and the ability of the whitefly vectors to develop insecticide-resistance, there is a growing need to develop and deploy strategies that do not rely on insecticides. The reduction in pesticide use will greatly increase the need for genetic resistance to more viruses in more crop plants. Resistance combined with selected IPM strategies could become a viable means to increase yields in crops produced in open fields despite the presence of whitefly-transmitted viruses.

  3. Comparative and Mixture Effect of Cynodon Dactylon, ElectroMagnetic Field and Insulin on Diabetic Mouse.

    Science.gov (United States)

    Nafisi, Saeid; Nezhady, Mohammad Ali Mohammad; Asghari, Mohammad Hossein

    2012-12-01

    New investigations are in progress to find some alternative treatments for diabetes mellitus. Herbs are some of the interesting medications in this regard. Cynodon dactylon (C.d) is a potential plant to be considered as a new medication. On the other hand, the effect of the Electromagnetic Field (EMF) on bio organisms is becoming clearer. In this study, the effect of C.d, EMF and insulin have been investigated on the diabetic mouse. Diabetes was induced by a combination of ketamine (60 mg/Kg) and xylazine (10 mg/Kg) which induces a sustained hyperglycemia. Mice were divided into 12 groups: 1) control, 2) normal saline, 3 and 4) 50mg/Kg C.d, 5 and 6) 100 mg/Kg C.d, 7) insulin, 8) insulin and C.d, 9) EMF (110 KHz, 700±20 mG), 10) insulin and EMF, 11) EMF plus C.d and 12) insulin plus C.d and EMF. Blood glucose level was measured after 5 and 60 minutes in C.d administrated groups, and 5 minutes in the other groups by a glucometer set. The data were analyzed by ANOVA and different means were compared by Tukey and Bonferroni tests (p<0.05). According to results, both dosages of C.d had significant lowering effect on blood glucose level. The first dose was more effective than the second, and its impact was just like insulin. The 6(th), 9(th) and 10(th) groups were significant, also. However, they did not show a higher effect than insulin or C.d. The application of EMF had a significant effect compared to the second group, but it did not reduce the glucose level to the normal range. The effect of the 8th group was very impressive and the mean glucose levels in this group were lower than the control group. Considering the data, C.d is a good alternative medication for diabetes mellitus.

  4. Gap opening and tuning in single-layer graphene with combined electric and magnetic field modulation

    Institute of Scientific and Technical Information of China (English)

    Lin Xin; Wang Hai-Long; Pan Hui; Xu Huai-Zhe

    2011-01-01

    The energy band structure of single-layer graphene under one-dimensional electric and magnetic field modulation is theoretically investigated. The criterion for bandgap opening at the Dirac point is analytically derived with a two-fold degeneracy second-order perturbation method. It is shown that a direct or an indirect bandgap semiconductor could be realized in a single-layer graphene under some specific configurations of the electric and magnetic field arrangement. Due to the bandgap generated in the single-layer graphene, the Klein tunneling observed in pristine graphene is completely suppressed.

  5. Electron polar cap and the boundary of open geomagnetic field lines.

    Science.gov (United States)

    Evans, L. C.; Stone, E. C.

    1972-01-01

    A total of 333 observations of the boundary of the polar access region for electrons (energies greater than 530 keV) provides a comprehensive map of the electron polar cap. The boundary of the electron polar cap, which should occur at the latitude separating open and closed field lines, is consistent with previously reported closed field line limits determined from trapped-particle data. The boundary, which is sharply defined, seems to occur at one of three discrete latitudes. Although the electron flux is generally uniform across the polar cap, a limited region of reduced access is observed about 10% of the time.

  6. Signature of open magnetic field lines in the extended solar corona and of solar wind acceleration

    Science.gov (United States)

    Antonucci, E.; Giordano, S.; Benna, C.; Kohl, J. L.; Noci, G.; Michels, J.; Fineschi, S.

    1997-01-01

    The observations carried out with the ultraviolet coronagraph spectrometer onboard the Solar and Heliospheric Observatory (SOHO) are discussed. The purpose of the observations was to determine the line of sight and radial velocity fields in coronal regions with different magnetic topology. The results showed that the regions where the high speed solar wind flows along open field lines are characterized by O VI 1032 and HI Lyman alpha 1216 lines. The global coronal maps of the line of sight velocity were reconstructed. The corona height, where the solar wind reaches 100 km/s, was determined.

  7. Agricultural and Management Practices and Bacterial Contamination in Greenhouse versus Open Field Lettuce Production

    Science.gov (United States)

    Holvoet, Kevin; Sampers, Imca; Seynnaeve, Marleen; Jacxsens, Liesbeth; Uyttendaele, Mieke

    2014-01-01

    The aim of this study was to gain insight into potential differences in risk factors for microbial contamination in greenhouse versus open field lettuce production. Information was collected on sources, testing, and monitoring and if applicable, treatment of irrigation and harvest rinsing water. These data were combined with results of analysis on the levels of Escherichia coli as a fecal indicator organism and the presence of enteric bacterial pathogens on both lettuce crops and environmental samples. Enterohemorragic Escherichia coli (EHEC) PCR signals (vt1 or vt2 positive and eae positive), Campylobacter spp., and Salmonella spp. isolates were more often obtained from irrigation water sampled from open field farms (21/45, 46.7%) versus from greenhouse production (9/75, 12.0%). The open field production was shown to be more prone to fecal contamination as the number of lettuce samples and irrigation water with elevated E. coli was significantly higher. Farmers comply with generic guidelines on good agricultural practices available at the national level, but monitoring of microbial quality, and if applicable appropriateness of water treatment, or water used for irrigation or at harvest is restricted. These results indicate the need for further elaboration of specific guidelines and control measures for leafy greens with regard to microbial hazards. PMID:25546272

  8. Infant titi monkey behavior in the open field test and the effect of early adversity.

    Science.gov (United States)

    Larke, Rebecca H; Toubiana, Alice; Lindsay, Katrina A; Mendoza, Sally P; Bales, Karen L

    2017-09-01

    The open field test is commonly used to measure anxiety-related behavior and exploration in rodents. Here, we used it as a standardized novel environment in which to evaluate the behavioral response of infant titi monkeys (Callicebus cupreus), to determine the effect of presence of individual family members, and to assess how adverse early experience alters infant behavior. Infants were tested in the open field for 5 days at ages 4 and 6 months in four successive 5 min trials on each day. A transport cage, which was situated on one side of the open field, was either empty (non-social control) or contained the father, mother, or sibling. Infant locomotor, vocalization, and exploratory behavior were quantified. Results indicated that age, sex, social condition, and early experience all had significant effects on infant behavior. Specifically, infants were generally more exploratory at 6 months and male infants were more exploratory than females. Infants distinguished between social and non-social conditions but made few behavioral distinctions between the attachment figure and other individuals. Infants which had adverse early life experience demonstrated greater emotional and physical independence, suggesting that early adversity led to resiliency in the novel environment. © 2017 Wiley Periodicals, Inc.

  9. Deriving the four-string and open-closed string interactions from geometric string field theory

    International Nuclear Information System (INIS)

    Kaku, M.

    1990-01-01

    One of the questions concerning the covariant open string field theory is why there are two distinct BRST theories and why the four-string interaction appears in one version but not the other. The authors solve this mystery by showing that both theories are gauge-fixed versions of a higher gauge theory, called the geometric string field theory, with a new field, a string verbein e μσ νρ , which allows us to gauge the string length and σ parametrization. By fixing the gauge, the authors can derive the endpoint gauge (the covariantized light cone gauge), the midpoint gauge of Witten, or the interpolating gauge with arbitrary string length. The authors show explicitly that the four-string interaction is a gauge artifact of the geometric theory (the counterpart of the four-fermion instantaneous Coulomb term of QED). By choosing the interpolating gauge, they produce a new class of four-string interactions which smoothly interpolate between the endpoint gauge and the midpoint gauge (where it vanishes). Similarly, they can extract the closed string as a bound state of the open string, which appears in the endpoint gauge but vanishes in the midpoint gauge. Thus, the four-string and open-closed string interactions do not have to be added to the action as long as the string vierbein is included

  10. Foraging enrichment modulates open field response to monosodium glutamate in mice.

    Science.gov (United States)

    Onaolapo, Olakunle J; Onaolapo, Adejoke Y; Akanmu, Moses A; Olayiwola, Gbola

    2015-07-01

    Environmental enrichment can enhance expression of species-specific behaviour. While foraging enrichment is encouraged in laboratory animals, its impact on novelty induced behaviour remain largely unknown. Here, we studied behavioural response of mice to acute and subchronic oral monosodium glutamate (MSG) in an open field with /without foraging enrichment. Adult male mice, assigned to five groups were administered vehicle (distilled water), or one of four selected doses of MSG (10, 20, 40 and 80 mg/kg) for 21 days. Open field novelty induced behaviours i.e. horizontal locomotion, rearing and grooming were assessed after the first and last doses of MSG. Results were analysed using MANOVA followed by Tukey HSD multiple comparison test and expressed as mean ± S.E.M. Following acute MSG administration without enrichment, locomotor activity reduced, grooming increased, while rearing activity reduced at lower doses and increased at higher doses. Subchronic administration without enrichment was associated with increased locomotor activity and reduction in grooming, rearing activity however still showed a biphasic response. Addition of enrichment with acute administration resulted in sustained reduction in locomotor and rearing activities with a biphasic grooming response. Subchronically, there was reduction in horizontal locomotion, biphasic rearing response and sustained increase in grooming activity. Behavioural response to varying doses of MSG as observed in the open field is affected by modifications such as foraging enrichment, which can reverse or dampen the central effects seen irrespective of duration of administration.

  11. [Effects of psychological stress on performances in open-field test of rats and tyrosine's modulation].

    Science.gov (United States)

    Chen, Wei-Qiang; Cheng, Yi-Yong; Li, Shu-Tian; Hong, Yan; Wang, Dong-Lan; Hou, Yue

    2009-02-01

    To explore the effects of different doses of tyrosine modulation on behavioral performances in open field test of psychological stress rats. The animal model of psychological stress was developed by restraint stress for 21 days. Wistar rats were randomly assigned to five groups (n = 10) as follows: control group (CT), stress control group (SCT), low, medium and high-doses of tyrosine modulation stress groups (SLT, SMT and SIT). The changes of behavioral performances were examined by open-field test. Serum levels of cortisol, norepinephrine and dopamine were also detected. The levels of serum cortisol were all increased obviously in the four stress groups, and their bodyweight gainings were diminished. The behavioral performances of SCT rats in open-field test were changed significantly in contrast to that of CT rats. However, The behavioral performances of SMT and SHT rats were not different from that of CT rats. In addition, the serum levels of norepinephrine and dopamine were downregulated obviously in SCT and SLT groups, and no differences were observed in other groups. Psychological stress can impair body behavioral performances, and moderate tyrosine modulation may improve these abnormal changes. The related mechanisms may be involved with the changes of norepinephrine and dopamine.

  12. Habituation of medaka (Oryzias latipes) demonstrated by open-field testing.

    Science.gov (United States)

    Matsunaga, Wataru; Watanabe, Eiji

    2010-10-01

    Habituation to novel environments is frequently studied to analyze cognitive phenotypes in animals, and an open-field test is generally conducted to investigate the changes that occur in animals during habituation. The test has not been used in behavioral studies of medaka (Oryzias latipes), which is recently being used in behavioral research. Therefore, we examined the open-field behavior of medaka on the basis of temporal changes in 2 conventional indexes of locomotion and position. The findings of our study clearly showed that medaka changed its behavior through multiple temporal phases as it became more familiar with new surroundings; this finding is consistent with those of other ethological studies in animals. During repeated open-field testing on 2 consecutive days, we observed that horizontal locomotion on the second day was less than that on the first day, which suggested that habituation is retained in fish for days. This temporal habituation was critically affected by water factors or visual cues of the tank, thereby suggesting that fish have spatial memory of their surroundings. Thus, the data from this study will afford useful fundamental information for behavioral phenotyping of medaka and for elucidating cognitive phenotypes in animals. Copyright (c) 2010 Elsevier B.V. All rights reserved.

  13. Gender-related response in open-field activity following developmental nicotine exposure in rats.

    Science.gov (United States)

    Romero, Roland D; Chen, Wei-Jung A

    2004-08-01

    Smoking during pregnancy may lead to low birthweight and behavioral alterations in the offspring. In this study, the effects of developmental nicotine exposure on the somatic growth of the offspring and the behavioral performance in the open-field test were examined. Sprague-Dawley female rats were implanted with nicotine (35 mg for 21-day time release; NIC 35) or placebo pellets on gestational day (GD) 8 (postblastocyst implantation). A normal control group with no pellet implant was also included. There was a significantly higher maternal weight gain in the placebo group possibly due to a larger litter size. However, there were no significant differences in body weights among all three treatment groups for male and female offspring. The amount of activity, measured by the total number of crossings in the open-field test, indicated a gender difference in baseline level and pattern of ambulatory activity, with less activity (lower number of crossings) in male offspring and an increase in the activity of the female offspring as a function of testing day. The increase in the ambulatory activity of the female offspring was observed in the placebo and normal, but not the NIC 35 group suggesting that developmental nicotine exposure interferes with open-field activity, and this behavioral alteration is gender related. Copyright 2004 Elsevier Inc.

  14. Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma.

    Science.gov (United States)

    Naito, Tomoko; Yoshikawa, Keiji; Mizoue, Shiro; Nanno, Mami; Kimura, Tairo; Suzumura, Hirotaka; Shiraga, Fumio

    2015-01-01

    To analyze the relationship between intraocular pressure (IOP) and the progression of visual field defects in Japanese primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) patients. The subjects of the study were patients undergoing treatment for POAG or NTG who had performed visual field tests at least ten times with a Humphrey field analyzer (Swedish interactive thresholding algorithm standard, C30-2 program). The progression of visual field defects was defined by a significantly negative value of the mean deviation slope at the final visual field test during the follow-up period. The relationships between the progression of visual field defects and IOP, as well as other clinical factors, were retrospectively analyzed. A total of 156 eyes of 156 patients were included in the analysis. Significant progression of visual field defects was observed in 70 eyes of 70 patients (44.9%), while no significant progression was evident in 86 eyes of 86 patients (55.1%). The eyes with visual field defect progression had significantly lower baseline IOP (Pfield defect progression than in eyes without (Pfield defects. In NTG, IOP management should take into account not only achieving the target IOP, but also minimizing the fluctuation of IOP during follow-up period.

  15. Similar reliability and equivalent performance of female and male mice in the open field and water-maze place navigation task.

    Science.gov (United States)

    Fritz, Ann-Kristina; Amrein, Irmgard; Wolfer, David P

    2017-09-01

    Although most nervous system diseases affect women and men differentially, most behavioral studies using mouse models do not include subjects of both sexes. Many researchers worry that data of female mice may be unreliable due to the estrous cycle. Here, we retrospectively evaluated sex effects on coefficient of variation (CV) in 5,311 mice which had performed the same place navigation protocol in the water-maze and in 4,554 mice tested in the same open field arena. Confidence intervals for Cohen's d as measure of effect size were computed and tested for equivalence with 0.2 as equivalence margin. Despite the large sample size, only few behavioral parameters showed a significant sex effect on CV. Confidence intervals of effect size indicated that CV was either equivalent or showed a small sex difference at most, accounting for less than 2% of total group to group variation of CV. While female mice were potentially slightly more variable in water-maze acquisition and in the open field, males tended to perform less reliably in the water-maze probe trial. In addition to evaluating variability, we also directly compared mean performance of female and male mice and found them to be equivalent in both water-maze place navigation and open field exploration. Our data confirm and extend other large scale studies in demonstrating that including female mice in experiments does not cause a relevant increase of data variability. Our results make a strong case for including mice of both sexes whenever open field or water-maze are used in preclinical research. © 2017 The Authors. American Journal of Medical Genetics Part C Published by Wiley Periodicals, Inc.

  16. Similar reliability and equivalent performance of female and male mice in the open field and water‐maze place navigation task

    Science.gov (United States)

    Fritz, Ann‐Kristina; Amrein, Irmgard

    2017-01-01

    Although most nervous system diseases affect women and men differentially, most behavioral studies using mouse models do not include subjects of both sexes. Many researchers worry that data of female mice may be unreliable due to the estrous cycle. Here, we retrospectively evaluated sex effects on coefficient of variation (CV) in 5,311 mice which had performed the same place navigation protocol in the water‐maze and in 4,554 mice tested in the same open field arena. Confidence intervals for Cohen's d as measure of effect size were computed and tested for equivalence with 0.2 as equivalence margin. Despite the large sample size, only few behavioral parameters showed a significant sex effect on CV. Confidence intervals of effect size indicated that CV was either equivalent or showed a small sex difference at most, accounting for less than 2% of total group to group variation of CV. While female mice were potentially slightly more variable in water‐maze acquisition and in the open field, males tended to perform less reliably in the water‐maze probe trial. In addition to evaluating variability, we also directly compared mean performance of female and male mice and found them to be equivalent in both water‐maze place navigation and open field exploration. Our data confirm and extend other large scale studies in demonstrating that including female mice in experiments does not cause a relevant increase of data variability. Our results make a strong case for including mice of both sexes whenever open field or water‐maze are used in preclinical research. PMID:28654717

  17. Genetic and phenotypic correlations between feather pecking and open-field reponse in laying hens at two different ages

    NARCIS (Netherlands)

    Rodenburg, T.B.; Buitenhuis, A.J.; Ask, B.; Uitdehaag, K.A.; Koene, P.; Poel, van der J.J.; Arendonk, van J.A.M.; Bovenhuis, H.

    2004-01-01

    The object of this research was to study the relationship between feather pecking and open-field activity in laying hens at two different ages. A population of 550 birds of a laying hen cross was subjected to an open-field test at 5 and 29 weeks of age and to a social feather pecking test at 6 and

  18. Eliminating Glutamatergic Input onto Horizontal Cells Changes the Dynamic Range and Receptive Field Organization of Mouse Retinal Ganglion Cells.

    Science.gov (United States)

    Ströh, Sebastian; Puller, Christian; Swirski, Sebastian; Hölzel, Maj-Britt; van der Linde, Lea I S; Segelken, Jasmin; Schultz, Konrad; Block, Christoph; Monyer, Hannah; Willecke, Klaus; Weiler, Reto; Greschner, Martin; Janssen-Bienhold, Ulrike; Dedek, Karin

    2018-02-21

    In the mammalian retina, horizontal cells receive glutamatergic inputs from many rod and cone photoreceptors and return feedback signals to them, thereby changing photoreceptor glutamate release in a light-dependent manner. Horizontal cells also provide feedforward signals to bipolar cells. It is unclear, however, how horizontal cell signals also affect the temporal, spatial, and contrast tuning in retinal output neurons, the ganglion cells. To study this, we generated a genetically modified mouse line in which we eliminated the light dependency of feedback by deleting glutamate receptors from mouse horizontal cells. This genetic modification allowed us to investigate the impact of horizontal cells on ganglion cell signaling independent of the actual mode of feedback in the outer retina and without pharmacological manipulation of signal transmission. In control and genetically modified mice (both sexes), we recorded the light responses of transient OFF-α retinal ganglion cells in the intact retina. Excitatory postsynaptic currents (EPSCs) were reduced and the cells were tuned to lower temporal frequencies and higher contrasts, presumably because photoreceptor output was attenuated. Moreover, receptive fields of recorded cells showed a significantly altered surround structure. Our data thus suggest that horizontal cells are responsible for adjusting the dynamic range of retinal ganglion cells and, together with amacrine cells, contribute to the center/surround organization of ganglion cell receptive fields in the mouse. SIGNIFICANCE STATEMENT Horizontal cells represent a major neuronal class in the mammalian retina and provide lateral feedback and feedforward signals to photoreceptors and bipolar cells, respectively. The mode of signal transmission remains controversial and, moreover, the contribution of horizontal cells to visual processing is still elusive. To address the question of how horizontal cells affect retinal output signals, we recorded the light

  19. Displacement and stress fields around rock fractures opened by irregular overpressure variations

    Directory of Open Access Journals (Sweden)

    Shigekazu eKusumoto

    2014-05-01

    Full Text Available Many rock fractures are entirely driven open by fluids such as ground water, geothermal water, gas, oil, and magma. These are a subset of extension fractures (mode I cracks; e.g., dikes, mineral veins and joints referred to as hydrofractures. Field measurements show that many hydrofractures have great variations in aperture. However, most analytical solutions for fracture displacement and stress fields assume the loading to be either constant or with a linear variation. While these solutions have been widely used, it is clear that a fracture hosted by heterogeneous and anisotropic rock is normally subject to loading that is neither constant nor with a linear variation. Here we present new general solutions for the displacement and stress fields around hydrofractures, modelled as two-dimensional elastic cracks, opened by irregular overpressure variations given by the Fourier cosine series. Each solution has two terms. The first term gives the displacement and stress fields due to the average overpressure acting inside the crack; it is given by the initial term of the Fourier coefficients expressing the overpressure variation. The second term gives the displacement and stress fields caused by the overpressure variation; it is given by general terms of the Fourier coefficients and solved through numerical integration. Our numerical examples show that the crack aperture variation closely reflects the overpressure variation. Also, that the general displacement and stress fields close to the crack follow the overpressure variation but tend to be more uniform far from the crack. The present solutions can be used to estimate the displacement and stress fields around any fluid-driven crack, that is, any hydrofracture, as well as its aperture, provided the variation in overpressure can be described by Fourier series. The solutions add to our understanding of local stresses, displacements, and fluid transport associated with hydrofractures in the crust.

  20. A model to relate wind tunnel measurements to open field odorant emissions from liquid area sources

    Science.gov (United States)

    Lucernoni, F.; Capelli, L.; Busini, V.; Sironi, S.

    2017-05-01

    Waste Water Treatment Plants are known to have significant emissions of several pollutants and odorants causing nuisance to the near-living population. One of the purposes of the present work is to study a suitable model to evaluate odour emissions from liquid passive area sources. First, the models describing volatilization under a forced convection regime inside a wind tunnel device, which is the sampling device that typically used for sampling on liquid area sources, were investigated. In order to relate the fluid dynamic conditions inside the hood to the open field and inside the hood a thorough study of the models capable of describing the volatilization phenomena of the odorous compounds from liquid pools was performed and several different models were evaluated for the open field emission. By means of experimental tests involving pure liquid acetone and pure liquid butanone, it was verified that the model more suitable to describe precisely the volatilization inside the sampling hood is the model for the emission from a single flat plate in forced convection and laminar regime, with a fluid dynamic boundary layer fully developed and a mass transfer boundary layer not fully developed. The proportionality coefficient for the model was re-evaluated in order to account for the specific characteristics of the adopted wind tunnel device, and then the model was related with the selected model for the open field thereby computing the wind speed at 10 m that would cause the same emission that is estimated from the wind tunnel measurement furthermore, the field of application of the proposed model was clearly defined for the considered models during the project, discussing the two different kinds of compounds commonly found in emissive liquid pools or liquid spills, i.e. gas phase controlled and liquid phase controlled compounds. Lastly, a discussion is presented comparing the presented approach for emission rates recalculation in the field, with other approaches

  1. The integration of open access journals in the scholarly communication system: Three science fields

    DEFF Research Database (Denmark)

    Faber Frandsen, Tove

    2009-01-01

    across disciplines. This study is an analysis of the citing behaviour in journals within three science fields: biology, mathematics, and pharmacy and pharmacology. It is a statistical analysis of OAJs as well as non-OAJs including both the citing and cited side of the journal to journal citations......The greatest number of open access journals (OAJs) is found in the sciences and their influence is growing. However, there are only a few studies on the acceptance and thereby integration of these OAJs in the scholarly communication system. Even fewer studies provide insight into the differences....... The multivariate linear regression reveals many similarities in citing behaviour across fields and media. But it also points to great differences in the integration of OAJs. The integration of OAJs in the scholarly communication system varies considerably across fields. The implications for bibliometric research...

  2. Identification of BKCa channel openers by molecular field alignment and patent data-driven analysis

    Directory of Open Access Journals (Sweden)

    Yaseen Gigani

    2016-01-01

    Full Text Available In this work, we present the first comprehensive molecular field analysis of patent structures on how the chemical structure of drugs impacts the biological binding. This task was formulated as searching for drug structures to reveal shared effects of substitutions across a common scaffold and the chemical features that may be responsible. We used the SureChEMBL patent database, which provides search of the patent literature using keyword-based functionality, as a query engine. The extraction of data of the BKCa channel openers and aligning them for molecular field similarity with newly designed structures did provide a probable validation method with accurate values. Therefore, in an attempt to increase the true positives, we report a procedure that functions on a multiple analyses modeled on molecular field similarity and common sub-structural search with consensus scoring and high confidence values to obtain greater accuracy during conventional virtual screening.

  3. Field-oriented control of five-phase induction motor with open-end stator winding

    Directory of Open Access Journals (Sweden)

    Listwan Jacek

    2016-09-01

    Full Text Available The mathematical model of the five-phase squirrel-cage induction motor and the system of the dual five-phase voltage source inverter have been presented. The control methods and control systems of the field-oriented control of the five-phase induction motor with an open-end stator winding are described. The structures of the direct fieldoriented control system (DFOC and the Indirect Field-oriented control system (IFOC with PI controllers in outer and inner control loops are analyzed. A method of space vector modulation used to control the system of the dual five-phase voltage source inverter has been discussed. The results of simulation studies of the field-oriented control methods are presented. Comparative analysis of the simulation results was carried out.

  4. Oxygen plasma assisted end-opening and field emission enhancement in vertically aligned multiwall carbon nanotubes

    Energy Technology Data Exchange (ETDEWEB)

    Mathur, A. [NIBEC, School of Engineering, University of Ulster, Jordanstown, BT37 0QB (United Kingdom); Roy, S.S., E-mail: sinharoy@ualberta.ca [Department of Mechanical Engineering, University of Alberta, Edmonton, T6T 2G8 (Canada); Hazra, K.S. [Department of Physics, IIT Bombay, Powai, Mumbai-400076 (India); Wadhwa, S. [NIBEC, School of Engineering, University of Ulster, Jordanstown, BT37 0QB (United Kingdom); Ray, S.C. [School of Physics, University of the Witwatersrand, WITS 2050, Johannesburg (South Africa); Mitra, S.K. [Department of Mechanical Engineering, University of Alberta, Edmonton, T6T 2G8 (Canada); Misra, D.S. [Department of Physics, IIT Bombay, Powai, Mumbai-400076 (India); McLaughlin, J.A. [NIBEC, School of Engineering, University of Ulster, Jordanstown, BT37 0QB (United Kingdom)

    2012-05-15

    Highlights: Black-Right-Pointing-Pointer We showed Ar/O{sub 2} plasma can be effective for the end opening of aligned CNTs. Black-Right-Pointing-Pointer The field emission property was dramatically enhanced after plasma modification. Black-Right-Pointing-Pointer Microstructures were clearly understood by Raman and SEM analysis. Black-Right-Pointing-Pointer Surface wet-ability at various functionalised conditions was studied. - Abstract: This paper highlights the changes in micro-structural and field emission properties of vertically aligned carbon nanotubes (VACNTs) via oxygen plasma treatment. We find that exposure of very low power oxygen plasma (6 W) at 13.56 MHz for 15-20 min, opens the tip of vertically aligned CNTs. Scanning electron microscopy and transmission electron microscopy images were used to identify the quality and micro-structural changes of the nanotube morphology and surfaces. Raman spectra showed that the numbers of defects were increased throughout the oxygen plasma treatment process. In addition, the hydrophobic nature of the VACNTs is altered significantly and the contact angle decreases drastically from 110 Degree-Sign to 40 Degree-Sign . It was observed that the electron field emission (EFE) characteristics are significantly enhanced. The turn-on electric field (ETOE) of CNTs decreased from {approx}0.80 V {mu}m{sup -1} (untreated) to {approx}0.60 V {mu}m{sup -1} (oxygen treated). We believe that the open ended VACNTs would be immensely valuable for applications such as micro/nanofluidic based filtering elements and display devices.

  5. Comparison between visual field defect in pigmentary glaucoma and primary open-angle glaucoma.

    Science.gov (United States)

    Nilforushan, Naveed; Yadgari, Maryam; Jazayeri, Anisalsadat

    2016-10-01

    To compare visual field defect patterns between pigmentary glaucoma and primary open-angle glaucoma. Retrospective, comparative study. Patients with diagnosis of primary open-angle glaucoma (POAG) and pigmentary glaucoma (PG) in mild to moderate stages were enrolled in this study. Each of the 52 point locations in total and pattern deviation plot (excluding 2 points adjacent to blind spot) of 24-2 Humphrey visual field as well as six predetermined sectors were compared using SPSS software version 20. Comparisons between 2 groups were performed with the Student t test for continuous variables and the Chi-square test for categorical variables. Thirty-eight eyes of 24 patients with a mean age of 66.26 ± 11 years (range 48-81 years) in the POAG group and 36 eyes of 22 patients with a mean age of 50.52 ± 11 years (range 36-69 years) in the PG group were studied. (P = 0.00). More deviation was detected in points 1, 3, 4, and 32 in total deviation (P = 0.03, P = 0.015, P = 0.018, P = 0.023) and in points 3, 4, and 32 in pattern deviation (P = 0.015, P = 0.049, P = 0.030) in the POAG group, which are the temporal parts of the field. It seems that the temporal area of the visual field in primary open-angle glaucoma is more susceptible to damage in comparison with pigmentary glaucoma.

  6. [C57BL/6 mice open field behaviour qualitatively depends on arena size].

    Science.gov (United States)

    Lebedev, I V; Pleskacheva, M G; Anokhin, K V

    2012-01-01

    Open field behavior is well known to depend on physical characteristics of the apparatus. However many of such effects are poorly described especially with using of modern methods of behavioral registration and analysis. The previous results of experiments on the effect of arena size on behavior are not numerous and contradictory. We compared the behavioral scores of four groups of C57BL/6 mice in round open field arenas of four different sizes (diameter 35, 75, 150 and 220 cm). The behavior was registered and analyzed using Noldus EthoVision, WinTrack and SegmentAnalyzer software. A significant effect of arena size was found. Traveled distance and velocity increased, but not in proportion to increase of arena size. Moreover a significant effect on segment characteristics of the trajectory was revealed. Detailed behavior analysis revealed drastic differences in trajectory structure and number of rears between smaller (35 and 75 cm) and bigger (150 and 220 cm) arenas. We conclude, that the character of exploration in smaller and bigger arenas depends on relative size of central open zone in arena. Apparently its extension increases the motivational heterogeneity of space, that requires another than in smaller arenas, strategy of exploration.

  7. Air pollutant emissions from rice straw open field burning in India, Thailand and the Philippines

    International Nuclear Information System (INIS)

    Gadde, Butchaiah; Bonnet, Sebastien; Menke, Christoph; Garivait, Savitri

    2009-01-01

    Rice is a widely grown crop in Asia. China (30%) and India (21%) contribute to about half of the world's total rice production. In this study, three major rice-producing countries in Asia are considered, India, Thailand and the Philippines (the later two contributing 4% and 2% of the world's rice production). Rice straw is one of the main field based residues produced along with this commodity and its applications vary widely in the region. Although rice production practises vary from one country to another, open burning of straw is a common practice in these countries. In this study, an approach was followed aiming at (a) determining the quantity of rice straw being subject to open field burning in those countries, (b) congregating pollutant specific emissions factors for rice straw burning, and (c) quantifying the resulting air pollutant emissions. Uncertainties in the results obtained as compared to a global approach are also discussed. - This research work contributes to enhance scientific knowledge for estimating air pollutant emissions from open burning of crop residues and improve emission results accuracy.

  8. Evaluation of the Effect of Low-Frequency Electromagnetic Fields on in Vitro Growth and Maturation of Mouse Oocytes

    Directory of Open Access Journals (Sweden)

    F Barzegari Firouzabadi

    2012-05-01

    Full Text Available Introduction: Access to modern methods for increasing the percentage of in vitro human and animal mature oocytes can be useful in the treatment of some forms of human infertility as well as proliferation of many domestic and wild animals which generation is endangered. Effect of low- frequency electromagnetic fields on in vitro growth and maturation of mouse oocytes is recently considered as a new approach. In this study we evaluated the effect of low- frequency electromagnetic field on in vitro growth and maturation of mouse oocyte. Methods: In this study electromagnetic fields with frequencies of 5, 50 and 100 Hz and 2mT intensity were used. For observation of the effect of electromagnetic field four groups were selected: Group 1 as control group, which included 35 prenatal follicles (immature oocytes. Groups 2, 3 and 4were exposed to 5, 50 and 100 Hz electromagnetic fields, respectively. Results: Prenatal follicles exposed to 5 and 50 Hz frequencies showed no significant changes in diameter and survival rates. In contrast at a frequency of 100 Hz in 72-hour culture period a significant increase in diameter(155μm, follicles livability power(59%, oocyte maturation(52% and GVBD(39% was shown in comparison to other experimental groups and control group(P <0.05. Conclusion: Low-frequency magnetic field effects gene expression and thus protein synthesis, cell division, proliferation and behavior. Although this effect can be temporary, it can increase the percentage of ovulation for in vitro environment along with other environmental factors.

  9. Specvis: Free and open-source software for visual field examination.

    Science.gov (United States)

    Dzwiniel, Piotr; Gola, Mateusz; Wójcik-Gryciuk, Anna; Waleszczyk, Wioletta J

    2017-01-01

    Visual field impairment affects more than 100 million people globally. However, due to the lack of the access to appropriate ophthalmic healthcare in undeveloped regions as a result of associated costs and expertise this number may be an underestimate. Improved access to affordable diagnostic software designed for visual field examination could slow the progression of diseases, such as glaucoma, allowing for early diagnosis and intervention. We have developed Specvis, a free and open-source application written in Java programming language that can run on any personal computer to meet this requirement (http://www.specvis.pl/). Specvis was tested on glaucomatous, retinitis pigmentosa and stroke patients and the results were compared to results using the Medmont M700 Automated Static Perimeter. The application was also tested for inter-test intrapersonal variability. The results from both validation studies indicated low inter-test intrapersonal variability, and suitable reliability for a fast and simple assessment of visual field impairment. Specvis easily identifies visual field areas of zero sensitivity and allows for evaluation of its levels throughout the visual field. Thus, Specvis is a new, reliable application that can be successfully used for visual field examination and can fill the gap between confrontation and perimetry tests. The main advantages of Specvis over existing methods are its availability (free), affordability (runs on any personal computer), and reliability (comparable to high-cost solutions).

  10. Kepler red-clump stars in the field and in open clusters

    DEFF Research Database (Denmark)

    Bossini, D.; Miglio, A.; Salaris, M.

    2017-01-01

    Convective mixing in helium-core-burning (HeCB) stars is one of the outstanding issues in stellar modelling. The precise asteroseismic measurements of gravity-mode period spacing (Delta Pi(1)) have opened the door to detailed studies of the near-core structure of such stars, which had not been...... possible before. Here, we provide stringent tests of various core-mixing scenarios against the largely unbiased population of red-clump stars belonging to the old-open clusters monitored by Kepler, and by coupling the updated precise inference on Delta Pi(1) in thousands of field stars with spectroscopic...... constraints. We find that models with moderate overshooting successfully reproduce the range observed of Delta Pi(1) in clusters. In particular, we show that there is no evidence for the need to extend the size of the adiabatically stratified core, at least at the beginning of the HeCB phase. This conclusion...

  11. Dissipation and Residues of Pyrethrins in Leaf Lettuce under Greenhouse and Open Field Conditions.

    Science.gov (United States)

    Pan, Lixiang; Feng, Xiaoxiao; Zhang, Hongyan

    2017-07-21

    Pyrethrins are nowadays widely used for prevention and control of insects in leaf lettuce. However, there is a concern about the pesticide residue in leaf lettuce. A reliable analytical method for determination of pyrethrins (pyrethrin-and П, cinerin І and П, and jasmolin І and П) in leaf lettuce was developed by using gas chromatography-mass spectrometry (GC-MS). Recoveries of pyrethrins in leaf lettuce at three spiking levels were 99.4-104.0% with relative standard deviations of 0.9-3.1% ( n = 5). Evaluation of dissipation and final residues of pyrethrins in leaf lettuce were determined at six different locations, including the open field, as well as under greenhouse conditions. The initial concentration of pyrethrins in greenhouse (0.57 mg/kg) was higher than in open field (0.25 mg/kg) and the half-life for pyrethrins disappearance in field lettuce (0.7 days) was less than that greenhouse lettuce (1.1 days). Factors such as rainfall, solar radiation, wind speed, and crop growth rate are likely to have caused these results. The final residue in leaf lettuce was far below the maximum residue limits (MRLs) (1 mg/kg established by the European Union (EU), Australia, Korea, Japan).

  12. Open-Access, Low-Magnetic-Field MRI System for Lung Research

    Science.gov (United States)

    Mair, Ross W.; Rosen, Matthew S.; Tsai, Leo L.; Walsworth, Ronald L.; Hrovat, Mirko I.; Patz, Samuel; Ruset, Iullian C.; Hersman, F. William

    2009-01-01

    An open-access magnetic resonance imaging (MRI) system is being developed for use in research on orientational/gravitational effects on lung physiology and function. The open-access geometry enables study of human subjects in diverse orientations. This system operates at a magnetic flux density, considerably smaller than the flux densities of typical other MRI systems, that can be generated by resistive electromagnet coils (instead of the more-expensive superconducting coils of the other systems). The human subject inhales air containing He-3 or Xe-129 atoms, the nuclear spins of which have been polarized by use of a laser beam to obtain a magnetic resonance that enables high-resolution gas space imaging at the low applied magnetic field. The system includes a bi-planar, constant-current, four-coil electromagnet assembly and associated electronic circuitry to apply a static magnetic field of 6.5 mT throughout the lung volume; planar coils and associated circuitry to apply a pulsed magnetic-field-gradient for each spatial dimension; a single, detachable radio-frequency coil and associated circuitry for inducing and detecting MRI signals; a table for supporting a horizontal subject; and electromagnetic shielding surrounding the electromagnet coils.

  13. Masking release by combined spatial and masker-fluctuation effects in the open sound field.

    Science.gov (United States)

    Middlebrooks, John C

    2017-12-01

    In a complex auditory scene, signals of interest can be distinguished from masking sounds by differences in source location [spatial release from masking (SRM)] and by differences between masker-alone and masker-plus-signal envelopes. This study investigated interactions between those factors in release of masking of 700-Hz tones in an open sound field. Signal and masker sources were colocated in front of the listener, or the signal source was shifted 90° to the side. In Experiment 1, the masker contained a 25-Hz-wide on-signal band plus flanking bands having envelopes that were either mutually uncorrelated or were comodulated. Comodulation masking release (CMR) was largely independent of signal location at a higher masker sound level, but at a lower level CMR was reduced for the lateral signal location. In Experiment 2, a brief signal was positioned at the envelope maximum (peak) or minimum (dip) of a 50-Hz-wide on-signal masker. Masking was released in dip more than in peak conditions only for the 90° signal. Overall, open-field SRM was greater in magnitude than binaural masking release reported in comparable closed-field studies, and envelope-related release was somewhat weaker. Mutual enhancement of masking release by spatial and envelope-related effects tended to increase with increasing masker level.

  14. Effect of vitrification on number of inner cell mass in mouse blastocysts in conventional straw, closed pulled straw, open pulled straw and cryoloop carriers

    International Nuclear Information System (INIS)

    Ghasem, S.; Negar, K.

    2013-01-01

    Objective: To compare the effect of using open and closed carriers on count of inner cell mass in vitrified mouse blastocyst after warming. Methods: The experimental study was conducted at Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, from April to September 2010. Forty female NMRI (Naval Medical Research Institute, USA) mice were injected with pregnant mares serum gonadotropin and human chorionic gonadotropin in order to induce super ovulation. Following the latter injection, two or three females were caged with the same-breed male mice. The presence of vaginal plug was examined the following morning. To collect blastocyst embryos, the pregnant females were sacrificed by cervical dislocation at 88-90 hours after the injection and dissected. Blastocysts were collected in phosphate-buffered saline and allocated to four groups: vitrification in conventional straw, closed pulled straw, open pulled straw and cryoloop. The vitrification solution was ethylene glycol, Ficol and sucrose (EFS) 20% and 40%. After storage for 1 month in liquid nitrogen, the blastocysts were thawed in 0.5 M sucrose then cultured in M16 medium. After 6 hours of culture, the number of expanded blastocysts was recorded and stained by double-dye technique. After staining, the number of total cell and inner cell mass was calculated. Results: The re-expansion rate of blastocysts in the cryoloop group (n=90; 78.26%) was significantly higher (p<0.05) than open pulled straw (n=83; 69.16%), closed pulled straw (n=68; 54.83%) and conventional straws (n=63; 51.21%) groups. Significant differences (p<0.05) in the number of inner cell mass in blastocysts vitrified in open pulled straws, closed straws and cryoloop with blastocysts cryopreserved in conventional straws. Conclusion: The re-expansion rate and total cell number of mouse blastocysts vitrified using open system had a better result compared with the closed system. The value of cryoloop and open pulled straws as carriers in

  15. Low-latitude boundary layer near noon: An open field line model

    Science.gov (United States)

    Lyons, L. R.; Schulz, M.; Pridmore-Brown, D. C.; Roeder, J. L.

    1994-01-01

    We propose that many features of the cusp and low-latitude boundary layer (LLBL) observed near noon MLT can be explained by interpreting the LLBL as being on open lines with an inner boundary at the separatrix between open and closed magnetic field lines. This interpretation places the poleward boundary of the LLBL and equatorward boundary of the cusp along the field line that bifurcates at the cusp neutral point. The interpretation accounts for the abrupt boundary of magnetosheath particles at the inner edge of the LLBL, a feature that is inconsistent with LLBL formation by diffusion onto closed field lines, and for the distribution of magnetosheath particles appearing more as one continuous region than as two distinct regions across the noon cusp/LLBL boundary. Furthermore, we can explain the existence of energetic radiation belt electrons and protons with differing pitch angle distributions within the LLBL and their abrupt cutoff at the poleward boundary of the LLBL. By modeling the LLBL and cusp region quantitatively, we can account for a hemispherical difference in the location of the equatorial boundary of the cusp that is observed to be dependent on the dipole tilt angle but not on the interplanetary magnetic field (IMF) x component. We also find important variations and hemispherical differences in that the size of the LLBL that should depend strongly upon the x component of the IMF. This prediction is observationally testable. Finally, we find that when the IMF is strongly northward, the LLBL may include a narrow region adjacent to the magnetopause where field lines are detached (i.e., have both ends connected to the IMF).

  16. Post-training scopolamine treatment induced maladaptive behavior in open field habituation task in rats.

    Directory of Open Access Journals (Sweden)

    Natalija Popović

    Full Text Available The effects of scopolamine on memory consolidation are controversial and depend on several factors (i.e. site of administration, time of administration and testing, dose, cognitive task, experimental protocol, specie, strain, etc.. Generally, the range dose of systemic administered scopolamine, used in memory consolidation studies, has varied from 0.05 to 50 mg/kg. However, according to the literature, the most frequently used doses of scopolamine efficient on memory consolidation, are 1 and 30 mg/kg, low and high doses, respectively. In open field habituation studies only lower doses of scopolamine were used to test memory consolidation. Therefore, in the present study we compared the effects of low (1 mg/kg and high (30 mg/kg scopolamine dose, on the open field habituation task, in male Wistar rats. Scopolamine was administered immediately after the acquisition task and animals were retested 48 h later on. On the retested day, the ambulation and rearing in the open field decreased in the same manner in all tested groups. In saline- and 1 mg/kg scopolamine-treated animals, the time spent in grooming significantly decreased in the habituation task, while the same parameter significantly increased in animals treated with 30 mg/kg of scopolamine. The defecation rate significantly decreased (control group, maintained (1 mg/kg of scopolamine treated animals or significantly increased (30 mg/kg of scopolamine treated group on retention test. In conclusion, the present data suggest that post-training scopolamine administration does not affect locomotion neither exploration in the habituation to a novel environment, but increases defecation and grooming, two behaviours associated with fearful and stressful situations.

  17. Pathological behavior of the open-shell restricted self-consistent-field equations

    International Nuclear Information System (INIS)

    Moscardo, F.; Alvarez-Collado, J.R.

    1979-01-01

    The possible solutions of open-shell restricted self-consistent-field equations for a doublet are studied for Li and Na atoms, according to the values of the parameters implied in those equations. A similar behavior, characterized by the presence of several variational solutions is observed in both atoms. Some of these solutions can be assigned to excited configurations. Excitation energies are in good agreement with experimental data. Doublet stability for the solutions obtained has been studied, discussing the saddle-point character present in those solutions associated to excited configurations

  18. Pathological behavior of the open-shell restricted self-consistent-field equations

    Energy Technology Data Exchange (ETDEWEB)

    Moscardo, F.; Alvarez-Collado, J.R.

    1979-02-01

    The possible solutions of open-shell restricted self-consistent-field equations for a doublet are studied for Li and Na atoms, according to the values of the parameters implied in those equations. A similar behavior, characterized by the presence of several variational solutions is observed in both atoms. Some of these solutions can be assigned to excited configurations. Excitation energies are in good agreement with experimental data. Doublet stability for the solutions obtained has been studied, discussing the saddle-point character present in those solutions associated to excited configurations.

  19. High-latitude convection on open and closed field lines for large IMF B(y)

    Science.gov (United States)

    Moses, J. J.; Crooker, N. U.; Gorney, D. J.; Siscoe, G. L.

    1985-01-01

    S3-3 electric field observations for August 23, 1976, show a single convection cell engulfing the northern polar cap. The flow direction is that for a positive IMF B(y) component. The particle data indicate that nearly half the duskside sunward flow occurs on closed field lines whereas the dawnside flow is entirely on open field lines. This is interpreted in terms of an IMF B(y)-induced deformation in the polar cap boundary, where the deformation moves with the convective flow. Thus, convection streamlines cross the deformed polar cap boundary, but no flow crosses the boundary because it is carried by the flow. Since southern hemisphere convection is expected to occur with the opposite sense of rotation, closed field lines that will be forced to tilt azimuthally are predicted. On the nightside the tilt produces a y component of the magnetic field in the same direction as the IMF for either sign of IMF B(y). This interpretation is consistent with observations of a greater y component in the plasma sheet than the tail lobes, which are difficult to understand in terms of the common explanation of IMF penetration. Alternatives to this interpretation are also discussed.

  20. Image-guided spinal injection procedures in open high-field MRI with vertical field orientation: feasibility and technical features

    Energy Technology Data Exchange (ETDEWEB)

    Streitparth, F.; Walter, T.; Wonneberger, U.; Wagner, M.; Hermann, K.G.; Hamm, B.; Teichgraeber, U. [Charite, Humboldt-Universitaet zu Berlin, Department of Radiology, Berlin (Germany); Chopra, S. [Charite-Universitaetsmedizin Berlin, Campus Virchow Klinikum, Department of General, Visceral, and Transplantation Surgery, Berlin (Germany); Wichlas, F. [Charite-Universitaetsmedizin Berlin, Campus Virchow Klinikum, Center for Musculoskeletal Surgery, Berlin (Germany)

    2010-02-15

    We prospectively evaluated the feasibility and technical features of MR-guided lumbosacral injection procedures in open high-field MRI at 1.0 T. In a CuSO{sub 4}.5H{sub 2}O phantom and five human cadaveric spines, fluoroscopy sequences (proton-density-weighted turbo spin-echo (PDw TSE), T1w TSE, T2w TSE; balanced steady-state free precession (bSSFP), T1w gradient echo (GE), T2w GE) were evaluated using two MRI-compatible 20-G Chiba-type needles. Artefacts were analysed by varying needle orientation to B{sub 0}, frequency-encoding direction and slice orientation. Image quality was described using the contrast-to-noise ratio (CNR). Subsequently, a total of 183 MR-guided nerve root (107), facet (53) and sacroiliac joint (23) injections were performed in 53 patients. In vitro, PDw TSE sequence yielded the best needle-tissue contrasts (CNR = 45, 18, 15, 9, and 8 for needle vs. fat, muscle, root, bone and sclerosis, respectively) and optimal artefact sizes (width and tip shift less than 5 mm). In vivo, PDw TSE sequence was sufficient in all cases. The acquisition time of 2 s facilitated near-real-time MRI guidance. Drug delivery was technically successful in 100% (107/107), 87% (46/53) and 87% (20/23) of nerve root, facet and sacroiliac joint injections, respectively. No major complications occurred. The mean procedure time was 29 min (range 19-67 min). MR-guided spinal injections in open high-field MRI are feasible and accurate using fast TSE sequence designs. (orig.)

  1. The behaviour of the paradise fish (Macropodus opercularis) in two different open-fields. A correlation study.

    Science.gov (United States)

    Gerlai, R; Csányi, V

    1987-01-01

    The behaviour of the paradise fish in a traditional "closed" and in a new "transparent" open-field was investigated. The traditional way of measuring ambulation scores was extended by recording ethologically defined behaviour units. The correlations found between the scores measured in the "closed" field and those measured in the "transparent" field are discussed in this paper.

  2. Enhanced heat transfer in partially open square cavities with thin fin by using electric field

    International Nuclear Information System (INIS)

    Kasayapanand, N.; Kiatsiriroat, T.

    2009-01-01

    Numerical modeling of the electric field effect on the natural convection in the partially open square cavities with thin fin attached is investigated. The interactions among electric, flow, and temperature fields are analyzed by using a computational fluid dynamics technique. It is found that the flow and heat transfer enhancements are a decreasing function of the Rayleigh number. Moreover, the volume flow rate and heat transfer coefficient are substantially improved by electrohydrodynamic especially at low aperture size, high aperture position, and high inclined angle. Surprisingly, the maximum convective heat transfer is obtained at the minimum electrical energy consumption by placing electrodes at a suitable position. The optimum electrode arrangements for both single fin and multiple fins are also achieved

  3. Towards an Open Software Platform for Field Robots in Precision Agriculture

    DEFF Research Database (Denmark)

    Jensen, Kjeld; Larsen, Morten; Nielsen, Søren H

    2014-01-01

    Robotics in precision agriculture has the potential to improve competitiveness and increase sustainability compared to current crop production methods and has become an increasingly active area of research. Tractor guidance systems for supervised navigation and implement control have reached...... the market, and prototypes of field robots performing precision agriculture tasks without human intervention also exist. But research in advanced cognitive perception and behaviour that is required to enable a more efficient, reliable and safe autonomy becomes increasingly demanding due to the growing...... software complexity. A lack of collaboration between research groups contributes to the problem. Scientific publications describe methods and results from the work, but little field robot software is released and documented for others to use. We hypothesize that a common open software platform tailored...

  4. Determination of antenna factors using a three-antenna method at open-field test site

    Science.gov (United States)

    Masuzawa, Hiroshi; Tejima, Teruo; Harima, Katsushige; Morikawa, Takao

    1992-09-01

    Recently NIST has used the three-antenna method for calibration of the antenna factor of an antenna used for EMI measurements. This method does not require the specially designed standard antennas which are necessary in the standard field method or the standard antenna method, and can be used at an open-field test site. This paper theoretically and experimentally examines the measurement errors of this method and evaluates the precision of the antenna-factor calibration. It is found that the main source of the error is the non-ideal propagation characteristics of the test site, which should therefore be measured before the calibration. The precision of the antenna-factor calibration at the test site used in these experiments, is estimated to be 0.5 dB.

  5. Opening the Pandora's box of quantum spinor fields

    Energy Technology Data Exchange (ETDEWEB)

    Bonora, L. [International School for Advanced Studies-SISSA, Trieste (Italy); Silva, J.M.H. da [Universidade Estadual Paulista-UNESP, Departamento de Fisica e Quimica, Guaratingueta, SP (Brazil); Rocha, R. da [Universidade Federal do ABC-UFABC, Centro de Matematica, Computacao e Cognicao, Santo Andre (Brazil)

    2018-02-15

    Lounesto's classification of spinors is a comprehensive and exhaustive algorithm that, based on the bilinears covariants, discloses the possibility of a large variety of spinors, comprising regular and singular spinors and their unexpected applications in physics and including the cases of Dirac, Weyl, and Majorana as very particular spinor fields. In this paper we pose the problem of an analogous classification in the framework of second quantization. We first discuss in general the nature of the problem. Then we start the analysis of two basic bilinear covariants, the scalar and pseudoscalar, in the second quantized setup, with expressions applicable to the quantum field theory extended to all types of spinors. One can see that an ampler set of possibilities opens up with respect to the classical case. A quantum reconstruction algorithm is also proposed. The Feynman propagator is extended for spinors in all classes. (orig.)

  6. Economies: An Open Access Journal for the Field of Development Macroeconomics

    Directory of Open Access Journals (Sweden)

    Ralf Fendel

    2013-01-01

    Full Text Available Economies (ISSN 2227-7099 is a new international, peer-reviewed open access journal for the academic fields of development economics and macroeconomics. While the latter seems to be clearly defined, development economics is not, because it is related to nearly all traditional economic sub-disciplines such as macroeconomics, international trade and finance, as well as microeconomics and public finance. Typically, academic field journals of development economics cover all those economic sub-disciplines. Economies instead focuses mainly on the macroeconomic perspective of economic development and it intends to publish academic research that is of strong macroeconomic policy relevance. In general, contributions in Economies should foster understanding of the macroeconomic process of economic development, with the process of development not exclusively being reserved to what we typically call developing countries. Also, the group of developed economies is still developing in the sense of improving their living standards further.

  7. Open-System Quantum Annealing in Mean-Field Models with Exponential Degeneracy*

    Directory of Open Access Journals (Sweden)

    Kostyantyn Kechedzhi

    2016-05-01

    Full Text Available Real-life quantum computers are inevitably affected by intrinsic noise resulting in dissipative nonunitary dynamics realized by these devices. We consider an open-system quantum annealing algorithm optimized for such a realistic analog quantum device which takes advantage of noise-induced thermalization and relies on incoherent quantum tunneling at finite temperature. We theoretically analyze the performance of this algorithm considering a p-spin model that allows for a mean-field quasiclassical solution and, at the same time, demonstrates the first-order phase transition and exponential degeneracy of states, typical characteristics of spin glasses. We demonstrate that finite-temperature effects introduced by the noise are particularly important for the dynamics in the presence of the exponential degeneracy of metastable states. We determine the optimal regime of the open-system quantum annealing algorithm for this model and find that it can outperform simulated annealing in a range of parameters. Large-scale multiqubit quantum tunneling is instrumental for the quantum speedup in this model, which is possible because of the unusual nonmonotonous temperature dependence of the quantum-tunneling action in this model, where the most efficient transition rate corresponds to zero temperature. This model calculation is the first analytically tractable example where open-system quantum annealing algorithm outperforms simulated annealing, which can, in principle, be realized using an analog quantum computer.

  8. Electronically rotated and translated field-free line generation for open bore magnetic particle imaging.

    Science.gov (United States)

    Top, Can Barış; Ilbey, Serhat; Güven, Hüseyin Emre

    2017-12-01

    We propose a coil arrangement for open bore field-free line (FFL) magnetic particle imaging (MPI) system, which is suitable for accessing the subject from the sides. The purpose of this study is twofold, to show that the FFL can be rotated and translated electronically in a volume of interest with this arrangement and to analyze the current, voltage and power requirements for a 1 T/m gradient human sized scanner for a 200 mm diameter × 200 mm height cylindrical field of view (FOV). We used split coils side by side with alternating current directions to generate a field-free line. Employing two of these coil groups, one of which is rotated 90 degrees with respect to the other, a rotating FFL was generated. We conducted numerical simulations to show the feasibility of this arrangement for three-dimensional (3D) electronical scan of the FFL. Using simulations, we obtained images of a two-dimensional (2D) in silico dot phantom for a human size scanner with system matrix-based reconstruction. Simulations showed that the FFL can be generated and rotated in one plane and can be translated in two axes, allowing for 3D imaging of a large subject with the proposed arrangement. Human sized scanner required 63-215 kW power for the selection field coils to scan the focus inside the FOV. The proposed setup is suitable for FFL MPI imaging with an open bore configuration without the need for mechanical rotation, which is preferable for clinical usage in terms of imaging time and patient access. Further studies are necessary to determine the limitations imposed by peripheral nerve stimulation, and to optimize the system parameters and the sequence design. © 2017 American Association of Physicists in Medicine.

  9. Twenty-three generations of mice bidirectionally selected for open-field thigmotaxis: selection response and repeated exposure to the open field.

    Science.gov (United States)

    Leppänen, Pia K; Ravaja, N; Ewalds-Kvist, S B M

    2006-03-01

    We examined: (a) the response to bidirectional selection for open-field (OF) thigmotaxis in mice for 23 generations and (b) the effects of repeated exposure (during 5 days) on different OF behaviors in the selectively bred high OF thigmotaxis (HOFT) and low OF thigmotaxis (LOFT) mice. A total of 2049 mice were used in the study. Prior to the testing in the selection experiment, the mice were exposed to the OF apparatus for approximately 2 min on each of 4 consecutive days. Thus, the selection was based on the scores registered on the 5th day after the four habituation periods. The HOFT mice were more thigmotactic than the LOFT mice in almost each generation. The HOFT mice also tended to rear less than the LOFT mice, which was explained by the inverse relationship between emotionality and exploratory tendencies. The lines did not generally differ in ambulation. Sex differences were found in thigmotaxis, ambulation, and rearing. In the repeated exposure experiment, the development of nine different OF behaviors across the 5 days of testing was addressed. Both lines ambulated, explored, and reared most on the 1st, 4th, and 5th days. Grooming and radial latency decreased and thigmotaxis increased linearly across the testing days. Line differences were found in ambulation, exploration, grooming, and rearing, while sex differences were manifested in ambulation and exploration. The line difference in thigmotaxis was evident only on the 5th day. Temporal changes were partially at variance with the general assumptions. OF thigmotaxis was found to be a powerful characteristic for producing two diverging lines of mice.

  10. Mycorrhization of containerised Pinus nigra seedlings with Suillus granulatus under open field conditions

    Energy Technology Data Exchange (ETDEWEB)

    Lazarevic, J.; Keca, N.; Martinovie, A.

    2012-07-01

    Seedling mycorrhization acts as an efficient tool for improving the quality of seedlings. In this study, the effectiveness of Suillus granulatus, originating from Pinus heldreichii forests (Montenegro), to produce containerized ectomycorrhizal seedlings of autochthonous Pinus nigra in open field conditions was investigated. Spore (106, 107, 108) and vegetative (1:16, 1:8, 1:4) inoculation on ectomycorrhizal formation and seedling growth were tested. Spore and vegetative inoculums of autochthonous Pisolithus arhizus were used in the same trial as additional control treatments. The utilization of vegetative and spore inoculums of autochthonous S. granulatus has proven to be an effective method of obtaining containerized ectomycorrhizal P. nigra seedlings under open field conditions after 11 months. S. granulatus spore inoculations resulted in well developed ectomycorrhiza, decreasing the growth of the P. nigra seedlings in the first growing season. Mycelial inoculations resulted in slightly developed S. granulatus ectomycorrhiza, which increased the growth of the seedlings. Therefore, it would be feasible to use spore inocula of S. granulatus, with 10{sup 6} spores per plant, to produce ectomycorrhizal P. nigra plants on a large scale. Controlled mycorrhizal inoculation of seedlings is not a common practice in Montenegrin and Serbian nurseries; as such, the obtained results will contribute to the enhancement of nursery production of Pinus nigra and other conifers. This also could be assumed as a starting point for many further efforts and investigations with autochthonous fungal and plant material in this region. (Author) 47 refs.

  11. Exploratory rearing: a context- and stress-sensitive behavior recorded in the open-field test.

    Science.gov (United States)

    Sturman, Oliver; Germain, Pierre-Luc; Bohacek, Johannes

    2018-02-16

    Stressful experiences are linked to anxiety disorders in humans. Similar effects are observed in rodent models, where anxiety is often measured in classic conflict tests such as the open-field test. Spontaneous rearing behavior, in which rodents stand on their hind legs to explore, can also be observed in this test yet is often ignored. We define two forms of rearing, supported rearing (in which the animal rears against the walls of the arena) and unsupported rearing (in which the animal rears without contacting the walls of the arena). Using an automated open-field test, we show that both rearing behaviors appear to be strongly context dependent and show clear sex differences, with females rearing less than males. We show that unsupported rearing is sensitive to acute stress, and is reduced under more averse testing conditions. Repeated testing and handling procedures lead to changes in several parameters over varying test sessions, yet unsupported rearing appears to be rather stable within a given animal. Rearing behaviors could therefore provide an additional measure of anxiety in rodents relevant for behavioral studies, as they appear to be highly sensitive to context and may be used in repeated testing designs.

  12. Function of the centromedial amygdala in reward devaluation and open-field activity.

    Science.gov (United States)

    Kawasaki, K; Glueck, A C; Annicchiarico, I; Papini, M R

    2015-09-10

    The present research aimed at determining the role played by the amygdala in reward devaluation using transient inactivation induced by lidocaine microinfusions into the centromedial region. Two situations involving reward devaluation were tested in rats: consummatory successive negative contrast (cSNC) and anticipatory negative contrast (ANC). In cSNC, rats exposed to a downshift from 32% to 4% sucrose consume less 4% sucrose than rats always exposed to 4% sucrose. Extensive evidence suggests that reward devaluation in the cSNC situation is accompanied by negative emotion. In ANC, rats consume less 4% sucrose when each session is closely followed by access to 32% sucrose rather than by 4% sucrose. Evidence suggests that reward devaluation in the ANC situation does not involve negative emotions; rather, ANC appears to involve Pavlovian anticipation of the higher value solution. To test the effects of lidocaine microinfusions in a situation known to induce negative emotion, but unrelated to reward devaluation, animals were also exposed to a lighted open field. Centromedial amygdala inactivation reduced the cSNC effect and increased exploratory behavior in the open field, both effects consistent with a reduction in negative emotional state. However, no detectable effects of amygdala inactivation were observed in the ANC situation. These results suggest that, first, the function of the amygdala is not unique to reward devaluation and, second, it is concerned with tagging the devaluation experience with aversive valence. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

  13. Maternal enrichment affects prenatal hippocampal proliferation and open-field behaviors in female offspring mice.

    Science.gov (United States)

    Maruoka, Takashi; Kodomari, Ikuko; Yamauchi, Rena; Wada, Etsuko; Wada, Keiji

    2009-04-17

    The maternal environment is thought to be important for fetal brain development. However, the effects of maternal environment are not fully understood. Here, we investigated whether enrichment of the maternal environment can influence prenatal brain development and postnatal behaviors in mice. An enriched environment is a housing condition with several objects such as a running wheel, tube and ladder, which are thought to increase sensory, cognitive and motor stimulation in rodents compared with standard housing conditions. First, we measured the number of BrdU-positive cells in the hippocampal dentate gyrus of fetuses from pregnant dams housed in an enriched environment. Our results revealed that maternal enrichment influences cell proliferation in the hippocampus of female, but not male, fetuses. Second, we used the open-field test to investigate postnatal behaviors in the offspring of dams housed in the enriched environment during pregnancy. We found that maternal enrichment significantly affects the locomotor activity and time spent in the center of the open-field in female, but not male, offspring. These results indicate that maternal enrichment influences prenatal brain development and postnatal behaviors in female offspring.

  14. Place and Response Learning in the Open-field Tower Maze.

    Science.gov (United States)

    Lipatova, Olga; Campolattaro, Matthew M; Toufexis, Donna J; Mabry, Erin A

    2015-10-28

    This protocol describes how the Open-field Tower Maze (OFTM) paradigm is used to study spatial learning in rodents. This maze is especially useful for examining how rats learn to use a place- or response-learning to successfully navigate in an open-field arena. Additionally, this protocol describes how the OFTM differs from other behavioral maze paradigms that are commonly used to study spatial learning in rodents. The OFTM described in this article was adapted from the one previously described by Cole, Clipperton, and Walt (2007). Specifically, the OFTM was created to test spatial learning in rodents without the experimenter having to consider how "stress" might play a role as a confounding variable. Experiments have shown that stress-alone can significantly affect cognitive function(1). The representative results section contains data from an experiment that used the OFTM to examine the effects of estradiol treatment on place- and response-learning in adult female Sprague Dawley rats(2). Future studies will be designed to examine the role of the hippocampus and striatum in place- and response-learning in the OFTM.

  15. Influence of fogging lenses and cycloplegia on open-field automatic refraction.

    Science.gov (United States)

    Queirós, A; González-Méijome, J; Jorge, J

    2008-07-01

    To compare refractive values measured with and without cycloplegia, or with fogging lenses, using an open-field auto-refractor. One hundred and forty-two young adults were enrolled from a university population; 96 were female (67.6%) and 46 were male (32.4%), the age range was 18-26 years (mean 22.3 +/- 3.7 years). The refraction measurement was obtained for the right eye of each subject with the Grand Seiko Auto Ref/Keratometer WAM-5500 (GS) under three conditions, always in this sequence: (1) without cycloplegia (GS), (2) without cycloplegia but using a + 2.00 D fogging lens (GS_2D) and (3) with cycloplegia (GS_cycl). When the average values of spherical equivalent were compared, both accommodation control strategies were almost equally successful: GS, M = -0.85 +/- 2.21 D; GC_2D, M = -0.53 +/- 2.10 D and GS_cycl, M = -0.57 +/- 2.24 D (Kruskal-Wallis test, p open-field autorefraction is performed in young adults.

  16. Automated measurement of spatial preference in the open field test with transmitted lighting.

    Science.gov (United States)

    Kulikov, Alexander V; Tikhonova, Maria A; Kulikov, Victor A

    2008-05-30

    New modification of the open field was designed to improve automation of the test. The main innovations were: (1) transmitted lighting and (2) estimation of probability to find pixels associated with an animal in the selected region of arena as an objective index of spatial preference. Transmitted (inverted) lighting significantly ameliorated the contrast between an animal and arena and allowed to track white animals with similar efficacy as colored ones. Probability as a measure of preference of selected region was mathematically proved and experimentally verified. A good correlation between probability and classic indices of spatial preference (number of region entries and time spent therein) was shown. The algorithm of calculation of probability to find pixels associated with an animal in the selected region was implemented in the EthoStudio software. Significant interstrain differences in locomotion and the central zone preference (index of anxiety) were shown using the inverted lighting and the EthoStudio software in mice of six inbred strains. The effects of arena shape (circle or square) and a novel object presence in the center of arena on the open field behavior in mice were studied.

  17. Assessment of anxiety in open field and elevated plus maze using infrared thermography.

    Science.gov (United States)

    Lecorps, Benjamin; Rödel, Heiko G; Féron, Christophe

    2016-04-01

    Due to their direct inaccessibility, affective states are classically assessed by gathering concomitant physiological and behavioral measures. Although such a dual approach to assess emotional states is frequently used in different species including humans, the invasiveness of procedures for physiological recordings particularly in smaller-sized animals strongly restricts their application. We used infrared thermography, a non-invasive method, to assess physiological arousal during open field and elevated plus maze tests in mice. By measuring changes in surface temperature indicative of the animals' emotional response, we aimed to improve the inherently limited and still controversial information provided by behavioral parameters commonly used in these tests. Our results showed significant and consistent thermal responses during both tests, in accordance with classical physiological responses occurring in stressful situations. Besides, we found correlations between these thermal responses and the occurrence of anxiety-related behaviors. Furthermore, initial temperatures measured at the start of each procedure (open field, elevated plus maze), which can be interpreted as a measure of the animals' initial physiological arousal, predicted the levels of activity and of anxiety-related behaviors displayed during the tests. Our results stress the strong link between physiological correlates of emotions and behaviors expressed during unconditioned fear tests. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Effect of interleukin-1beta on the behavior of rats during mild stress in the open-field test.

    Science.gov (United States)

    Pertsov, S S; Koplik, E V; Simbirtsev, A S; Kalinichenko, L S

    2009-11-01

    We studied the effect of interleukin-1beta on the behavior of rats with different individual typological characteristics during mild stress in the open-field test. Intraperitoneal injection of interleukin-1beta (5 microg/kg, 108 U/mg) was followed by a decrease in orientation and exploratory activity of passive and, particularly, of active animals in the open field. As differentiated from rats receiving physiological saline, the initial differences in behavioral characteristics of active and passive animals were not revealed in the repeated test after injection of interleukin-1beta. We conclude that interleukin-1beta abolishes the behavioral differences between active and passive specimens in the open field. These data suggest that administration of interleukin-1beta to rats leads to reorganization of the mechanisms for emotional evaluation of adverse emotiogenic factors under conditions of mild stress in the open-field test.

  19. Fast diffusion tensor magnetic resonance imaging of the mouse brain at ultrahigh-field: aiming at cohort studies.

    Directory of Open Access Journals (Sweden)

    Hans-Peter Müller

    Full Text Available INTRODUCTION: In-vivo high resolution diffusion tensor imaging (DTI of the mouse brain is often limited by the low signal to noise ratio (SNR resulting from the required small voxel sizes. Recently, cryogenically cooled resonators (CCR have demonstrated significant increase of the effective SNR. It is the objective of this study to enable fast DTI of the mouse brain. In this context, CCRs appear attractive for SNR improvement. METHODS: Three mice underwent a DTI examination at 156²×250 µm³ spatial resolution with a CCR at ultrahigh field (11.7T. Diffusion images were acquired along 30 gradient directions plus 5 references without diffusion encoding, resulting in a total acquisition time of 35 minutes. For comparison, mice additionally underwent a standardized 110 minutes acquisition protocol published earlier. Fractional anisotropy (FA and fiber tracking (FT results including quantitative tractwise fractional anisotropy statistics (TFAS were qualitatively and quantitatively compared. RESULTS: Qualitative and quantitative assessment of the calculated fractional anisotropy maps and fibre tracking results showed coinciding outcome comparing 35 minute scans to the standardized 110 minute scan. Coefficients of variation for ROI-based FA-comparison as well as for TFAS revealed comparable results for the different scanning protocols. CONCLUSION: Mouse DTI at 11.7 T was performed with an acquisition time of approximately 30 minutes, which is considered feasible for cohort studies. The rapid acquisition protocol reveals reliable and reproducible FA-values and FT reconstructions, thus allowing an experimental setup for in-vivo large scale whole brain murine DTI cohort studies.

  20. Behaviour in the open field predicts the number of KCl-induced cortical spreading depressions in rats

    OpenAIRE

    Bogdanov, Volodymyr Borysovych; Bogdanova, Olena Viktorivna; Koulchitsky, Stanislav Vladimirovich; Chauvel, Virginie; Multon, Sylvie; Makarchuk, Mykola Yukhymovych; Brennan, Kevin Christopher; Renshaw, Perry F.; Schoenen, Jean

    2012-01-01

    Anxiety disorders are known to be comorbid with migraine, and cortical spreading depression (CSD) is the most likely cause of the migraine aura. To search for possible correlations between susceptibility to CSD and anxiety we used the open field test in male Sprague-Dawley rats chronically treated with the preventive anti-migraine drugs valproate or riboflavin. Animals avoiding the central area of the open field chamber and those with less exploratory activity (i.e. rearing) were considered m...

  1. Genetically modified parthenocarpic eggplants: improved fruit productivity under both greenhouse and open field cultivation.

    Directory of Open Access Journals (Sweden)

    Pandolfini Tiziana

    2002-04-01

    Full Text Available Abstract Background Parthenocarpy, or fruit development in the absence of fertilization, has been genetically engineered in eggplant and in other horticultural species by using the DefH9-iaaM gene. The iaaM gene codes for tryptophan monoxygenase and confers auxin synthesis, while the DefH9 controlling regions drive expression of the gene specifically in the ovules and placenta. A previous greenhouse trial for winter production of genetically engineered (GM parthenocarpic eggplants demonstrated a significant increase (an average of 33% increase in fruit production concomitant with a reduction in cultivation costs. Results GM parthenocarpic eggplants have been evaluated in three field trials. Two greenhouse spring trials have shown that these plants outyielded the corresponding untransformed genotypes, while a summer trial has shown that improved fruit productivity in GM eggplants can also be achieved in open field cultivation. Since the fruits were always seedless, the quality of GM eggplant fruits was improved as well. RT-PCR analysis demonstrated that the DefH9-iaaM gene is expressed during late stages of fruit development. Conclusions The DefH9-iaaM parthenocarpic gene is a biotechnological tool that enhances the agronomic value of all eggplant genotypes tested. The main advantages of DefH9-iaaM eggplants are: i improved fruit productivity (at least 30–35% under both greenhouse and open field cultivation; ii production of good quality (marketable fruits during different types of cultivation; iii seedless fruit with improved quality. Such advantages have been achieved without the use of either male or female sterility genes.

  2. Dissipation and enantioselective degradation of plant growth retardants paclobutrazol and uniconazole in open field, greenhouse, and laboratory soils.

    Science.gov (United States)

    Wu, Chengwang; Sun, Jianqiang; Zhang, Anping; Liu, Weiping

    2013-01-15

    Greenhouses are increasingly important in human food supply. Pesticides used in greenhouses play important roles in horticulture; however, little is known about their behavior in greenhouse environments. This work investigates the dissipation and enantioselctive degradation of plant growth retardants including paclobutrazol and uniconazole in soils under three conditions (i.e., open field, greenhouse, and laboratory). The dissipation and enantioselective degradation of paclobutrazol and uniconazole in greenhouse were different from those in open field; they were more persistent in greenhouse than in open field soil. Leaching produced by rainfall is responsible for the difference in dissipation. Thus, local environmental impacts may occur more easily inside greenhouses, while groundwater may be more contaminated in open field. Spike concentrations of 5, 10, and 20 times the concentrations of native residues were tested for the enantioselective dissipation of the two pesticides; the most potent enantioselective degradation of paclobutrazol and uniconazole occurred at the 10 times that of the native residues in the greenhouse environments and at 20 times native residues in open field environments. The higher soil activity in greenhouses than in open fields was thought to be responsible for such a difference. The environmental risk and regulation of paclobutrazol and uniconazole should be considered at the enantiomeric level.

  3. Population dynamics and breeding patterns of multimammate mouse, Mastomys natalensis (Smith 1834), in irrigated rice fields in eastern Tanzania.

    Science.gov (United States)

    Mulungu, Loth S; Ngowo, Victoria; Mdangi, Mashaka; Katakweba, Abdul S; Tesha, Protas; Mrosso, Furaha P; Mchomvu, Mary; Sheyo, Paul M; Kilonzo, Bukhet S

    2013-03-01

    Multimammate mice are the most important vertebrate pests in Sub-Saharan Africa and are also reservoirs of many zoonotic diseases, including sylvan plague. This study investigated the population dynamics and breeding patterns of this mouse in irrigated rice cropping systems in eastern Tanzania. The multimammate mouse, Mastomys natalensis, population varied with habitat and months. Fallow land had a more abundant population than rice fields. The highest population peak was observed during the dry season from July to October. Mastomys natalensis is sexually active throughout the year in the study area, although it reaches the highest level in June and December when rice is at the maturity stage. This suggests that breeding is highly influenced by the presence of a rice crop in both seasons. More juvenile individuals were recorded in August and September, indicating that they were produced in the previous breeding months. The sex ratio of M. natalensis was not skewed to either males or females, indicating that it was at parity. Rodent population dynamics during the study periods in all habitats indicated that high birth rates accounted for the rapid population growth and turnover. Regular control and sustainable operations are thus essential if rodent pest populations are to be kept within tolerable limits. Copyright © 2012 Society of Chemical Industry.

  4. Towards an Open Software Platform for Field Robots in Precision Agriculture

    Directory of Open Access Journals (Sweden)

    Kjeld Jensen

    2014-06-01

    Full Text Available Robotics in precision agriculture has the potential to improve competitiveness and increase sustainability compared to current crop production methods and has become an increasingly active area of research. Tractor guidance systems for supervised navigation and implement control have reached the market, and prototypes of field robots performing precision agriculture tasks without human intervention also exist. But research in advanced cognitive perception and behaviour that is required to enable a more efficient, reliable and safe autonomy becomes increasingly demanding due to the growing software complexity. A lack of collaboration between research groups contributes to the problem. Scientific publications describe methods and results from the work, but little field robot software is released and documented for others to use. We hypothesize that a common open software platform tailored to field robots in precision agriculture will significantly decrease development time and resources required to perform experiments due to efficient reuse of existing work across projects and robot platforms. In this work we present the FroboMind software platform and evaluate the performance when applied to precision agriculture tasks.

  5. Open Field Study of Some Zea mays Hybrids, Lipid Compounds and Fumonisins Accumulation

    Science.gov (United States)

    Giorni, Paola; Dall’Asta, Chiara; Reverberi, Massimo; Scala, Valeria; Ludovici, Matteo; Cirlini, Martina; Galaverna, Gianni; Fanelli, Corrado; Battilani, Paola

    2015-01-01

    Lipid molecules are increasingly recognized as signals exchanged by organisms interacting in pathogenic and/or symbiotic ways. Some classes of lipids actively determine the fate of the interactions. Host cuticle/cell wall/membrane components such as sphingolipids and oxylipins may contribute to determining the fate of host–pathogen interactions. In the present field study, we considered the relationship between specific sphingolipids and oxylipins of different hybrids of Zea mays and fumonisin by F. verticillioides, sampling ears at different growth stages from early dough to fully ripe. The amount of total and free fumonisin differed significantly between hybrids and increased significantly with maize ripening. Oxylipins and phytoceramides changed significantly within the hybrids and decreased with kernel maturation, starting from physiological maturity. Although the correlation between fumonisin accumulation and plant lipid profile is certain, the data collected so far cannot define a cause-effect relationship but open up new perspectives. Therefore, the question—“Does fumonisin alter plant lipidome or does plant lipidome modulate fumonisin accumulation?”—is still open. PMID:26378580

  6. Open Field Study of Some Zea mays Hybrids, Lipid Compounds and Fumonisins Accumulation

    Directory of Open Access Journals (Sweden)

    Paola Giorni

    2015-09-01

    Full Text Available Lipid molecules are increasingly recognized as signals exchanged by organisms interacting in pathogenic and/or symbiotic ways. Some classes of lipids actively determine the fate of the interactions. Host cuticle/cell wall/membrane components such as sphingolipids and oxylipins may contribute to determining the fate of host–pathogen interactions. In the present field study, we considered the relationship between specific sphingolipids and oxylipins of different hybrids of Zea mays and fumonisin by F. verticillioides, sampling ears at different growth stages from early dough to fully ripe. The amount of total and free fumonisin differed significantly between hybrids and increased significantly with maize ripening. Oxylipins and phytoceramides changed significantly within the hybrids and decreased with kernel maturation, starting from physiological maturity. Although the correlation between fumonisin accumulation and plant lipid profile is certain, the data collected so far cannot define a cause-effect relationship but open up new perspectives. Therefore, the question—“Does fumonisin alter plant lipidome or does plant lipidome modulate fumonisin accumulation?”—is still open.

  7. Open-field behaviour in sheep following treatment with the neuroleptics azaperone and acetylpromazine.

    Science.gov (United States)

    Hughes, R N; Syme, L A; Syme, G J

    1977-03-23

    The behavior of individual Romney ewes in an open field was observed after intramuscular injection of isotonic saline or two doses of azaperone (0.5, 1.0 mg/kg) or acetylpromazine (0.1, 0.25 mg/kg). Azaperone significantly reduced the distance travelled, urination, and the time spent walking. However it increased nosing of the walls and floor (investigation). Azaperone also increased the numbers of sheep seen grazing and pawing and decreased the number heart vocalizing at least once. The only effect acetylpromazine had was to reduce the number of sheep heart vocalizing. The main results were interpreted as supporting a superior reduction of emotional behaviour by azaperone. It was therefore suggested that, as with pigs, azaperone might be useful for treating stress in sheep.

  8. Mangifera indica extract (Vimang) impairs aversive memory without affecting open field behaviour or habituation in rats.

    Science.gov (United States)

    Preissler, Thales; Martins, Márcio Rodrigo; Pardo-Andreu, Gilberto L; Henriques, João Antônio Pêgas; Quevedo, João; Delgado, Rene; Roesler, Rafael

    2009-06-01

    Vimang is an aqueous extract of Mangifera indica L, used in Cuba for the treatment of immunopathological disorders. Increasing evidence from preclinical studies indicates that Vimang displays antioxidant, antiallergic, analgesic and antiinflammatory actions. The present study investigated the effects of systemic administration of Vimang on behavioural outcomes of neurological function in rats. A single oral administration of Vimang produced an impairment of short- and long-term retention of memory for aversive training when given either 1 h pretraining or immediately posttraining, but not 8 h posttraining. Vimang did not affect open field behaviour or habituation. The results indicate that Vimang might induce deficits of emotionally motivated memory without affecting nonassociative memory, locomotion, exploratory behaviour or anxiety. (c) 2008 John Wiley & Sons, Ltd.

  9. Charge and current transport in open field lines turbulence: Influence of plasma-surface boundary conditions

    Energy Technology Data Exchange (ETDEWEB)

    Futtersack, R., E-mail: romain.futtersack@cea.fr [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); Universite Paul Sabatier Toulouse, LAPLACE, 118 Route de Narbonne, F-31062 Toulouse Cedex 9 (France); Tamain, P. [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); Hagelaar, G. [Universite Paul Sabatier Toulouse, LAPLACE, 118 Route de Narbonne, F-31062 Toulouse Cedex 9 (France); Ghendrih, Ph.; Simonin, A. [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France)

    2013-07-15

    We investigate the impact of both parallel and transverse boundary conditions on the current and charge transport in open field line systems using the TOKAM2D code, which solves a minimal model for interchange turbulence. Various limit test cases are discussed and analyzed. In the parallel direction, the sheath conductivity is found to play an essential role in the stabilization of large-scale potential structures, leading to the formation of transport channel or transport barrier respectively for an insulating end wall or a wall with an enhanced sheath conductivity. On another hand, the addition of transverse boundary conditions intrinsically changes the transport characteristics, influencing both radial profiles and probability density functions. It underlines that in some cases a detailed description of the plasma-wall interaction process is required to get a proper description of the current loop pattern that determines electrostatic turbulent transport.

  10. Crossfostering in mice selectively bred for high and low levels of open-field thigmotaxis.

    Science.gov (United States)

    Leppänen, Pia K; Ewalds-Kvist, S Béatrice M

    2005-02-01

    The main purpose of this research was to investigate whether the difference in open-field (OF) thigmotaxis between mice selectively bred for high and low levels of wall-seeking behavior originated from genetic or acquired sources. Unfostered, infostered, and crossfostered mice were compared in two experiments in which the effects of strain, sex, and fostering on ambulation, defecation, exploration, grooming, latency to move, radial latency, rearing, thigmotaxis, and urination were studied. These experiments revealed that OF thigmotaxis was unaffected by the foster condition and thus genetically determined. The selected strains of mice also diverged repeatedly with regard to exploration and rearing. The findings are in line with the previously described existence of an inverse relationship between emotionality and exploration.

  11. FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data.

    Science.gov (United States)

    Oostenveld, Robert; Fries, Pascal; Maris, Eric; Schoffelen, Jan-Mathijs

    2011-01-01

    This paper describes FieldTrip, an open source software package that we developed for the analysis of MEG, EEG, and other electrophysiological data. The software is implemented as a MATLAB toolbox and includes a complete set of consistent and user-friendly high-level functions that allow experimental neuroscientists to analyze experimental data. It includes algorithms for simple and advanced analysis, such as time-frequency analysis using multitapers, source reconstruction using dipoles, distributed sources and beamformers, connectivity analysis, and nonparametric statistical permutation tests at the channel and source level. The implementation as toolbox allows the user to perform elaborate and structured analyses of large data sets using the MATLAB command line and batch scripting. Furthermore, users and developers can easily extend the functionality and implement new algorithms. The modular design facilitates the reuse in other software packages.

  12. Open and closed loop manipulation of charged microchiplets in an electric field

    Energy Technology Data Exchange (ETDEWEB)

    Lu, J. P., E-mail: jplu@parc.com; Thompson, J. D.; Whiting, G. L.; Biegelsen, D. K.; Raychaudhuri, S.; Lujan, R.; Veres, J.; Lavery, L. L.; Völkel, A. R.; Chow, E. M. [Palo Alto Research Center, Inc., 3333 Coyote Hill Rd., Palo Alto, California 94304 (United States)

    2014-08-04

    We demonstrate the ability to orient, position, and transport microchips (“chiplets”) with electric fields. In an open-loop approach, modified four phase traveling wave potential patterns manipulate chiplets in a dielectric solution using dynamic template agitation techniques. Repeatable parallel assembly of chiplets is demonstrated to a positional accuracy of 6.5 μm using electrodes of 200 μm pitch. Chiplets with dipole surface charge patterns are used to show that orientation can be controlled by adding unique charge patterns on the chiplets. Chip path routing is also demonstrated. With a closed-loop control system approach using video feedback, dielectric, and electrophoretic forces are used to achieve positioning accuracy of better than 1 μm with 1 mm pitch driving electrodes. These chip assembly techniques have the potential to enable future printer systems where inputs are electronic chiplets and the output is a functional electronic system.

  13. Jet outflow and open field line measurements on the C-2U advanced beam-driven field-reversed configuration plasma experiment.

    Science.gov (United States)

    Sheftman, D; Gupta, D; Roche, T; Thompson, M C; Giammanco, F; Conti, F; Marsili, P; Moreno, C D

    2016-11-01

    Knowledge and control of the axial outflow of plasma particles and energy along open-magnetic-field lines are of crucial importance to the stability and longevity of the advanced beam-driven field-reversed configuration plasma. An overview of the diagnostic methods used to perform measurements on the open field line plasma on C-2U is presented, including passive Doppler impurity spectroscopy, microwave interferometry, and triple Langmuir probe measurements. Results of these measurements provide the jet ion temperature and axial velocity, electron density, and high frequency density fluctuations.

  14. Inability of Open-Field Autorefraction to Eliminate Accommodation in Preschoolers.

    Science.gov (United States)

    Kara, Caner; Petriçli, İkbal Seza

    2017-09-01

    To evaluate the effectiveness of the Shin-Nippon NVision-K 5001 autorefractometer (Rexxam Co. Ltd., Osaka, Japan) (also branded as the Grand Seiko WR-5100K; Grand Seiko Co. Ltd., Hiroshima, Japan) based on the open-field refractometry principle in refractive measurements of preschool children and to determine its ability to eliminate accommodation adequately. The refractive results of 114 preschool children who presented to the ophthalmology outpatient department for screening were evaluated. The measurements were obtained before and after cycloplegia with the Shin-Nippon NVision-K 5001 autorefractometer and after cycloplegia with retinoscopy, which is the gold standard. The results underwent vectorial transformation to produce the spherical equivalent (M) and two Jackson cross-cylinder (J0 and J45) values. All results were then subjected to statistical analysis. The difference between the measurements was evaluated with repeated measures analysis of variance. Included in the study were 106 preschool children (51 boys and 55 girls). The mean age was 5.3 ± 0.9 years (range: 3 to 6 years). Although statistically significantly more myopic results were obtained with non-cycloplegic measurements using the Shin-Nippon NVision-K 5001 autorefractometer (P .05). Cycloplegic J0 measurements were significantly lower (P .05). The Shin-Nippon NVision-K 5001/Grand Seiko WR-5100K open-field autorefractometer seems to be inadequate in eliminating accommodation in childhood. Measurements under cycloplegia continue to be the best method to ensure accurate results. [J Pediatr Ophthalmol Strabismus. 2017;54(5):311-318.]. Copyright 2017, SLACK Incorporated.

  15. Strain, Sex, and Open-Field Behavior: Factors Underlying the Genetic Susceptibility to Helplessness

    Science.gov (United States)

    Padilla, Eimeira; Barrett, Douglas W.; Shumake, Jason D.; Gonzalez-Lima, F.

    2009-01-01

    Learned helplessness represents a failure to escape after exposure to inescapable stress and may model human psychiatric disorders related to stress. Previous work has demonstrated individual differences in susceptibility to learned helplessness. In this study, we assessed different factors associated with this susceptibility, including strain, sex, and open-field behavior. Testing of three rat strains (Holtzman, Long-Evans, and Sprague-Dawley) revealed that Holtzman rats were the most susceptible to helplessness. Holtzman rats not only had the longest escape latencies following inescapable shock, but also showed spontaneous escape deficits in the absence of prior shock when tested with a fixed-ratio 2 (FR2) running response. Moreover, when tested with fixed-ratio 1 (FR1) running—an easy response normally unaffected by helplessness training in rats—inescapable shock significantly increased the escape latencies of Holtzman rats. Within the Holtzman strain, we confirmed recent findings that females showed superior escape performance and therefore appeared more resistant to helplessness than males. However, regression and covariance analyses suggest that this sex difference may be explained by more baseline ambulatory activity among females. In addition, some indices of novelty reactivity (greater exploration of novel vs. familiar open-field) predicted subsequent helpless behavior. In conclusion, Holtzman rats, and especially male Holtzman rats, have a strong predisposition to become immobile when stressed which interferes with their ability to learn active escape responses. The Holtzman strain therefore appears to be a commercially available model for studying susceptibility to helplessness in males, and novelty-seeking may be a marker of this susceptibility. PMID:19428642

  16. Static and dynamic evaluation of pelvic floor disorders with an open low-field tilting magnet

    International Nuclear Information System (INIS)

    Fiaschetti, V.; Pastorelli, D.; Squillaci, E.; Funel, V.; Rascioni, M.; Meschini, A.; Salimbeni, C.; Sileri, P.; Franceschilli, L.; Simonetti, G.

    2013-01-01

    Aim: To assess the feasibility of magnetic resonance defaecography (MRD) in pelvic floor disorders using an open tilting magnet with a 0.25 T static field and to compare the results obtained from the same patient both in supine and orthostatic positions. Materials and methods: From May 2010 to November 2011, 49 symptomatic female subjects (mean age 43.5 years) were enrolled. All the patients underwent MRD in the supine and orthostatic positions using three-dimensional (3D) hybrid contrast-enhanced (HYCE) sequences and dynamic gradient echo (GE) T1-weighted sequences. All the patients underwent conventional defaecography (CD) to correlate both results. Two radiologists evaluated the examinations; inter and intra-observer concordance was measured. The results obtained in the two positions were compared between them and with CD. Results: The comparison between CD and MRD found statistically significant differences in the evaluation of anterior and posterior rectocoele during defaecation in both positions and of rectal prolapse under the pubo-coccygeal line (PCL) during evacuation, only in the supine position (versus MRD orthostatic: rectal prolapse p < 0.0001; anterior rectocoele p < 0.001; posterior rectocoele p = 0.008; versus CD: rectal prolapse p < 0.0001; anterior rectocoele p < 0.001; posterior rectocoele p = 0.01). The value of intra-observer intra-class correlation coefficient (ICC) ranged from good to excellent; the interobserver ICC from moderate to excellent. Conclusion: MRD is feasible with an open low-field tilting magnet, and it is more accurate in the orthostatic position than in the supine position to evaluate pelvic floor disorders

  17. Maternal environment alters social interactive traits but not open-field behavior in Fischer 344 rats.

    Science.gov (United States)

    Yamamuro, Yutaka

    2008-10-01

    Although it is recognized that the genetic background governs behavioral phenotypes, environmental factors also play a critical role in the development of various behavioral processes. The maternal environment has a major impact on pups, and the cross-fostering procedure is used to determine the influence of early life experiences. The present study examined the influence of maternal environment on behavioral traits in inbred Fischer 344 (F344) rats. F344/DuCrlCrlj and Wistar (Crlj:WI) pups were fostered from postnatal day 1 as follows: Wistar pups raised by Wistar dams, F344 raised by Wistar, Wistar raised by F344, and F344 raised by F344. At 10 weeks of age, rats were randomly assigned to an open-field test and social interaction test. In the open-field test, irrespective of the rearing conditions, the activity during the first 1 min was significantly lower in F344 rats than in Wistar rats. Latency to the onset of movement showed no difference between groups. In the social interaction test, the recognition performance during the first 1 min in F344 raised by F344 was significantly shorter than that in the other groups. The onset of recognition to a novel social partner in F344 raised by F344 was significantly delayed, and the delay disappeared upon cross-fostering by Wistar dams. These results raise the possibility that the behavioral phenotype of F344 rats results from the interplay of genetic factors and maternal environment during early life, and that F344 rats are a strain with high susceptibility to rearing conditions for the formation of their emotionality.

  18. Environmental novelty and illumination modify ethanol-induced open-field behavioral effects in mice.

    Science.gov (United States)

    Fukushiro, Daniela F; Benetti, Liliane F; Josino, Fabiana S; Oliveira, Gabriela P; Fernandes, Maiara deM; Saito, Luis P; Uehara, Regina A; Wuo-Silva, Raphael; Oliveira, Camila S; Frussa-Filho, Roberto

    2010-03-01

    Both spontaneous and drug-induced animal behaviors can be modified by exposure to novel stimuli or different levels of environmental illumination. However, research into how these factors specifically impact ethanol (ETH)-induced behavioral effects is currently lacking. We aimed to investigate the effects of these two factors, considered separately or in conjunction, on ETH-induced acute hyperlocomotor effect and its sensitization in adult male Swiss mice. Mice were placed in a novel or familiar open-field under normal light (200 lx) or low light (9 lx) immediately after receiving an ip injection of either 1.8 g/kg ETH or saline (SAL). After 7 days, all animals received an ip challenge injection of 1.8 g/kg ETH, and were placed in the open-field under the same light conditions described above. Novelty increased central locomotion and decreased grooming, while low light increased grooming. Acute ETH administration increased both total and peripheral locomotion and these effects were potentiated by low light. Both low light and novelty were able to facilitate ETH-induced locomotor sensitization, which was detected by the central locomotion parameter. However, there was no synergism between the effects of these two modulating factors on ETH-induced behavioral sensitization. We conclude that both the acute behavioral effects of ETH and behavioral sensitization induced by previous administration of this drug can be critically modified by environmental factors. In addition, our study stresses the importance of using different behavioral parameters to evaluate the interaction between environmental factors and ETH effects. (c) 2009 Elsevier Inc. All rights reserved.

  19. [Neonatal Semax and saline injections induce open-field behavior changes in mice of different genotypes].

    Science.gov (United States)

    Shilova, O B; Markina, N V; Perepelkina, O V; Gichenok, I V; Korochkin, L I; Poletaeva, I I

    2004-01-01

    DBA/2, CBA mice, and their F1 hybrids (first series) and 101/HY and C3H mice (second series) were injected as neonates (2-7 days of life) with Semax (sc., 7 microg per animal). Semax is a peptide analogue of ACHT4-10 fragment which is resistant to degradation. The common feature of remote effects of both Semax and saline injections was the set of changes in the open-field behavior in adult (2.5- to 3-month-old) animals as compared to intact mice. Unexpectedly, the neonatal saline injections induced many changes in adult behavior, part of these effects being genotype-dependent. The most conspicuous shifts (genotype-dependent increase or decline) in freezing, grooming and rearing scores were displayed by DBA/2 and C3H mice, whereas the hole-poke frequencies were significantly changed in CBA and C3H mice. Squares crossed in the center of arena and rearing number were significantly increased in saline group of DBA/2 mice, whereas in Semax-injected DBA/2 group they were approximately equal to the level of intact mice. This means that the remote effects of noxious stimulation (injections of saline) were in some ways "compensated" as the result of concomitant peptide effect. At the same time, the numbers of freezing and grooming episodes were also increased in these groups. Because exploratory behavior and manifestations of anxiety increased or decreased simultaneously, it proves to be difficult to ascribe these changes to behavioral modulation along the "novelty seeking--anxiety" axis. In mice of other genotypes, changes in the same indices of the open-field behavior were revealed, but these changes were different in their direction. It was suggested that the complex patterns of postnatal behavior was the result of neonatal injections modulating subsequent brain development.

  20. Change in Visual Field Progression Following Treatment Escalation in Primary Open-angle Glaucoma.

    Science.gov (United States)

    Aptel, Florent; Bron, Alain M; Lachkar, Yves; Schweitzer, Cédric

    2017-10-01

    To evaluate the effect of treatment escalation on the rate of visual field progression in patients with primary open-angle glaucoma (POAG). Multicenter database study. We reviewed the electronic records of 171 patients with POAG under medical hypotensive treatment who underwent 5 consecutive visits 6 months apart before and after medical treatment escalation or additive laser trabeculoplasty. We calculated the rate of visual field progression (mean deviation change per year) before and after treatment escalation. The mean duration of follow-up was 5.1±0.5 years and the mean number of visual field examinations was 10.2±0.2. In 139 eyes with medical treatment escalation, the rate of progression was significantly reduced [from -0.57 to -0.29 dB/y; P=0.022; intraocular pressure (IOP) reduction 11.1%]. In detail, the rate of progression was significantly reduced after escalation from mono to dual therapy, dual to triple therapy, and from mono to triple therapy (-0.35 to -0.24 dB/y, P=0.018; -1.01 to -0.48 dB/y, P=0.038; -1.04 to -0.35 dB/y, P=0.020, respectively). In 32 eyes with additive laser trabeculoplasty, the rate of progression was significantly reduced (-0.60 to -0.24 dB/y; P=0.014; IOP reduction 9.4%). Medical treatment escalation or additive laser trabeculoplasty significantly reduced the rate of visual field progression in POAG. Larger IOP reduction has a greater probability of reducing glaucoma progression.

  1. Open quantum systems and the two-level atom interacting with a single mode of the electromagnetic field

    International Nuclear Information System (INIS)

    Sandulescu, A.; Stefanescu, E.

    1987-07-01

    On the basis of Lindblad theory of open quantum systems we obtain new optical equations for the system of two-level atom interacting with a single mode of the electromagnetic field. The conventional Block equations in a generalized form with field phases are obtained in the hypothesis that all the terms are slowly varying in the rotating frame.(authors)

  2. Prediction of the diffuse-field transmission loss of interior natural-ventilation openings and silencers.

    Science.gov (United States)

    Bibby, Chris; Hodgson, Murray

    2017-01-01

    The work reported here, part of a study on the performance and optimal design of interior natural-ventilation openings and silencers ("ventilators"), discusses the prediction of the acoustical performance of such ventilators, and the factors that affect it. A wave-based numerical approach-the finite-element method (FEM)-is applied. The development of a FEM technique for the prediction of ventilator diffuse-field transmission loss is presented. Model convergence is studied with respect to mesh, frequency-sampling and diffuse-field convergence. The modeling technique is validated by way of predictions and the comparison of them to analytical and experimental results. The transmission-loss performance of crosstalk silencers of four shapes, and the factors that affect it, are predicted and discussed. Performance increases with flow-path length for all silencer types. Adding elbows significantly increases high-frequency transmission loss, but does not increase overall silencer performance which is controlled by low-to-mid-frequency transmission loss.

  3. Field Portable Low Temperature Porous Layer Open Tubular Cryoadsorption Headspace Sampling and Analysis Part II: Applications*

    Science.gov (United States)

    Harries, Megan; Bukovsky-Reyes, Santiago; Bruno, Thomas J.

    2016-01-01

    This paper details the sampling methods used with the field portable porous layer open tubular cryoadsorption (PLOT-cryo) approach, described in Part I of this two-part series, applied to several analytes of interest. We conducted tests with coumarin and 2,4,6-trinitrotoluene (two solutes that were used in initial development of PLOT-cryo technology), naphthalene, aviation turbine kerosene, and diesel fuel, on a variety of matrices and test beds. We demonstrated that these analytes can be easily detected and reliably identified using the portable unit for analyte collection. By leveraging efficiency-boosting temperature control and the high flow rate multiple capillary wafer, very short collection times (as low as 3 s) yielded accurate detection. For diesel fuel spiked on glass beads, we determined a method detection limit below 1 ppm. We observed greater variability among separate samples analyzed with the portable unit than previously documented in work using the laboratory-based PLOT-cryo technology. We identify three likely sources that may help explain the additional variation: the use of a compressed air source to generate suction, matrix geometry, and variability in the local vapor concentration around the sampling probe as solute depletion occurs both locally around the probe and in the test bed as a whole. This field-portable adaptation of the PLOT-cryo approach has numerous and diverse potential applications. PMID:26726934

  4. Field portable low temperature porous layer open tubular cryoadsorption headspace sampling and analysis part II: Applications.

    Science.gov (United States)

    Harries, Megan; Bukovsky-Reyes, Santiago; Bruno, Thomas J

    2016-01-15

    This paper details the sampling methods used with the field portable porous layer open tubular cryoadsorption (PLOT-cryo) approach, described in Part I of this two-part series, applied to several analytes of interest. We conducted tests with coumarin and 2,4,6-trinitrotoluene (two solutes that were used in initial development of PLOT-cryo technology), naphthalene, aviation turbine kerosene, and diesel fuel, on a variety of matrices and test beds. We demonstrated that these analytes can be easily detected and reliably identified using the portable unit for analyte collection. By leveraging efficiency-boosting temperature control and the high flow rate multiple capillary wafer, very short collection times (as low as 3s) yielded accurate detection. For diesel fuel spiked on glass beads, we determined a method detection limit below 1 ppm. We observed greater variability among separate samples analyzed with the portable unit than previously documented in work using the laboratory-based PLOT-cryo technology. We identify three likely sources that may help explain the additional variation: the use of a compressed air source to generate suction, matrix geometry, and variability in the local vapor concentration around the sampling probe as solute depletion occurs both locally around the probe and in the test bed as a whole. This field-portable adaptation of the PLOT-cryo approach has numerous and diverse potential applications. Published by Elsevier B.V.

  5. Consequences of low or moderate prenatal ethanol exposures during gastrulation or neurulation for open field activity and emotionality in mice.

    Science.gov (United States)

    Schambra, Uta B; Nunley, Kevin; Harrison, Theresa A; Lewis, C Nicole

    In a previous study we used a mouse model for ethanol exposure during gastrulation or neurulation to investigate the effects of modest and occasional human drinking during the 3rd or 4th week of pregnancy (Schambra et al., 2015). Pregnant C57Bl/6J mice were treated by gavage during gastrulation on gestational day (GD) 7 or neurulation on GD8 with 2 doses 4h apart of either 2.4 or 2.9g ethanol/kg body weight, resulting in peak blood ethanol concentrations (BECs) of 104 and 177mg/dl, respectively. We found that mice exposed to the low dose on either day were significantly delayed in their neonatal sensorimotor development. In the present study, we tested the same cohort of mice in an open field as juveniles on postnatal day (PD) 23-25 and as young adults on PD65-67 for prenatal ethanol effects on exploration and emotionality with measures of activity, rearing, grooming and defecation. We evaluated the effects of dose, sex, day of treatment and day of birth by multiple regression analyses. We found that, compared to the respective gavage controls, juvenile mice that had been prenatally exposed to the low BEC on either GD7 or GD8 were significantly hypoactive on the first 2 test days, reared significantly more on the last 2 test days, and groomed and defecated significantly more on all 3 test days. Only mice that had been treated on GD7 remained hypoactive as adults. Juvenile mice prenatally exposed to the moderate BEC on GD7 groomed significantly more, while those exposed on GD8 reared and defecated significantly more. Sex differences were highly significant in adult control mice, with control males less active and more emotional than females. Similar, but smaller, sex differences were also evident in adults exposed to ethanol prenatally. Persistence into later life of a deleterious effect of premature birth (i.e., birth on GD19 rather than GD20) on weight and behavior was not consistently supported by these data. Importantly, mice shown previously to be delayed in

  6. Dynamics of the plasma injected into the gap of a plasma opening switch across a strong magnetic field

    International Nuclear Information System (INIS)

    Dolgachev, G. I.; Maslennikov, D. D.; Ushakov, A. G.; Fedotkin, A. S.; Khodeev, I. A.; Shvedov, A. A.

    2011-01-01

    A method is proposed to increase the linear charge density transferred through a plasma opening switch (POS) and, accordingly, reduce the POS diameter by enhancing the external magnetic field in the POS gap. Results are presented from experimental studies of the dynamics of the plasma injected into the POS gap across a strong magnetic field. The possibility of closing the POS gap by the plasma injected across an external magnetic field of up to 60 kG is demonstrated.

  7. OPEN CLUSTERS AS PROBES OF THE GALACTIC MAGNETIC FIELD. I. CLUSTER PROPERTIES

    Energy Technology Data Exchange (ETDEWEB)

    Hoq, Sadia; Clemens, D. P., E-mail: shoq@bu.edu, E-mail: clemens@bu.edu [Institute for Astrophysical Research, 725 Commonwealth Avenue, Boston University, Boston, MA 02215 (United States)

    2015-10-15

    Stars in open clusters are powerful probes of the intervening Galactic magnetic field via background starlight polarimetry because they provide constraints on the magnetic field distances. We use 2MASS photometric data for a sample of 31 clusters in the outer Galaxy for which near-IR polarimetric data were obtained to determine the cluster distances, ages, and reddenings via fitting theoretical isochrones to cluster color–magnitude diagrams. The fitting approach uses an objective χ{sup 2} minimization technique to derive the cluster properties and their uncertainties. We found the ages, distances, and reddenings for 24 of the clusters, and the distances and reddenings for 6 additional clusters that were either sparse or faint in the near-IR. The derived ranges of log(age), distance, and E(B−V) were 7.25–9.63, ∼670–6160 pc, and 0.02–1.46 mag, respectively. The distance uncertainties ranged from ∼8% to 20%. The derived parameters were compared to previous studies, and most cluster parameters agree within our uncertainties. To test the accuracy of the fitting technique, synthetic clusters with 50, 100, or 200 cluster members and a wide range of ages were fit. These tests recovered the input parameters within their uncertainties for more than 90% of the individual synthetic cluster parameters. These results indicate that the fitting technique likely provides reliable estimates of cluster properties. The distances derived will be used in an upcoming study of the Galactic magnetic field in the outer Galaxy.

  8. A search for extra-solar planetary transits in the field of open cluster NGC 6819

    Science.gov (United States)

    Street, Rachel Amanda

    The technique of searching for extra-solar planetary transits is investigated. This technique, which relies on detecting the brief, shallow eclipses caused by planets passing across the line of sight to the primary star, requires high-precision time-series photometry of large numbers of stars in order to detect these statistically rare events. Observations of 18000 stars in the field including the intermediate-age open cluster NGC 6819 are presented. This target field constrasts with the stellar environment surveyed by the radial velocity technique, which concentrates on the Solar neighbourhood. I present the data-reduction techniques used to obtain high-precision photometry in a semi-automated fashion for tens of thousands of stars at a time, together with an algorithm designed to search the resulting lightcurves for the transit signatures of hot Jupiter type planets. I describe simulations designed to test the detection efficiency of this algorithm and, for comparison, predict the number of transits expected from this data, assuming that hot Jupiter planets similar to HD 209458 are as common in the field of NGC 6819 as they are in the Solar neighbourhood. While no planetary transits have yet been identified, the detection of several very low amplitude eclipses by stellar companions demonstrates the effectiveness of the method. This study also indicates that stellar activity and particularly blending are significant causes of false detections. A useful additional consequence of studying this time-series photometry is the census it provides of some of the variable stars in the field. I report on the discovery of a variety of newly-discovered variables, including Algol-type detached eclipsing binaries which are likely to consist of M-dwarf stars. Further study of these stars is strongly recommended in order to help constrain models of stellar structure at the very low mass end. I conclude with a summary of this work in the context of other efforts being made in this

  9. Field determination of multipollutant, open area combustion source emission factors with a hexacopter unmanned aerial vehicle

    Science.gov (United States)

    Aurell, J.; Mitchell, W.; Chirayath, V.; Jonsson, J.; Tabor, D.; Gullett, B.

    2017-10-01

    An emission sensor/sampler system was coupled to a National Aeronautics and Space Administration (NASA) hexacopter unmanned aerial vehicle (UAV) to characterize gases and particles in the plumes emitted from open burning of military ordnance. The UAV/sampler was tested at two field sites with test and sampling flights spanning over 16 h of flight time. The battery-operated UAV was remotely maneuvered into the plumes at distances from the pilot of over 600 m and at altitudes of up to 122 m above ground level. While the flight duration could be affected by sampler payload (3.2-4.6 kg) and meteorological conditions, the 57 sampling flights, ranging from 4 to 12 min, were typically terminated when the plume concentrations of CO2 were diluted to near ambient levels. Two sensor/sampler systems, termed ;Kolibri,; were variously configured to measure particulate matter, metals, chloride, perchlorate, volatile organic compounds, chlorinated dioxins/furans, and nitrogen-based organics for determination of emission factors. Gas sensors were selected based on their applicable concentration range, light weight, freedom from interferents, and response/recovery times. Samplers were designed, constructed, and operated based on U.S. Environmental Protection Agency (EPA) methods and quality control criteria. Results show agreement with published emission factors and good reproducibility (e.g., 26% relative standard deviation for PM2.5). The UAV/Kolibri represents a significant advance in multipollutant emission characterization capabilities for open area sources, safely and effectively making measurements heretofore deemed too hazardous for personnel or beyond the reach of land-based samplers.

  10. Low mass planets in protoplanetary disks with net vertical magnetic fields: the Planetary Wake and Gap Opening

    OpenAIRE

    Zhu, Zhaohuan; Stone, James M.; Rafikov, Roman R.

    2013-01-01

    We study wakes and gap opening by low mass planets in gaseous protoplanetary disks threaded by net vertical magnetic fields which drive magnetohydrodynamical (MHD) turbulence through the magnetorotational instabilty (MRI), using three dimensional simulations in the unstratified local shearing box approximation. The wakes, which are excited by the planets, are damped by shocks similar to the wake damping in inviscid hydrodynamic (HD) disks. Angular momentum deposition by shock damping opens ga...

  11. Window opening behaviour: simulations of occupant behaviour in residential buildings using models based on a field survey

    DEFF Research Database (Denmark)

    Valentina, Fabi; Andersen, Rune Korsholm; Corgnati, Stefano Paolo

    2012-01-01

    Window opening behaviour has been shown to have a significant impact on airflow rates and hence energy consumption. Nevertheless, the inhabitant behaviour related to window opening in residential buildings is currently poorly investigated through both field surveys and building energy simulations....... In particular, reliable information regarding user behaviour in residential buildings is crucial for suitable prediction of building performance (energy consumption, indoor environmental quality, etc.). To face this issue, measurements of indoor climate and outdoor environmental parameters and window “opening...... and closing” actions were performed in 15 dwellings from January to August 2008 in Denmark. Probabilistic models of inhabitants’ window “opening and closing” behaviour were developed and implemented in the energy simulation software IDA ICE to improve window opening and closing strategies in simulations...

  12. A Measurement and Analysis of Buildup Region Dose for Open Field Photon Beams (Cobalt-60 through 24 MV)

    International Nuclear Information System (INIS)

    McCullough, Edwin C.

    2015-01-01

    The central axis depth dose in the build-up region (surface to d_m_a_x) of single open field photon beams (cobalt-60 through 24 MV) has been measured utilizing parallel plate and extrapolation chamber methodology. These data were used to derive, for a prescription dose of 100 cGy, values of surface dose, the maximum value of dose along the central axis (D_m_a_x) and the depth (nearest the surface) at which 90% of the prescription dose occurs (d_9_0). For both single and parallel opposed pair (POP) open field configurations, data are presented at field sizes of 5 × 5, 15 × 15 and 25 × 25 cm"2 for prescription depths of 10, 15 and 20 cm (midplane for POP). For the treatment machines, field sizes, and prescription depths studied, it is possible to conclude that: for single open field irradiation, surface dose values (as a percentage of the prescription dose) can be either low (<10%) or comparable to the prescription dose itself; for POP open fields, surface dose values are relatively independent of photon energy and midplane depth, and range between 30% and 70% of prescription dose, being principally dependent on field size; the depth of the initial 90 cGy point for a prescription dose of 100 cGy, d_9_0, was larger for POP fields. For either single or POP open field treatments, d_9_0 was always less than 22 mm, while for 6 MV or less, values of d_9_0 were less than 4 mm; D_m_a_x values can be very large (e.g., above 300 cGy) for certain treatment situations and are reduced significantly for POP treatments; for open field POP treatments, the percent reduction in D_m_a_x with each increment in beam energy above 10 MV is reduced over that seen at 10 MV or less and, possibly, this further reduction may be clinically insignificant; for open field POP treatments, changes in surface dose, d_9_0 and D_m_a_x with beam energy above 10 MV do not suggest, with regard to these specific build-up curve parameters, any obvious advantage for treatment with beam energies greater

  13. [Open-field behavioral study in rat hyperlipidemia combined with chronic unpredictable mild stress model].

    Science.gov (United States)

    Hu, Hua; Zhang, Yingchun; Xu, Yeqing; Liu, Chunfeng; Wang, Liwei

    2015-06-16

    To investigate behavioral changes in a rat hyperlipidemia model induced by high lipid feed combined with depression by Chronic Unpredictable Mild Stress (CUMS). A total of 40 rats were randomly divided into control (CON), control feed for 9 weeks followed by CUMS for 4 weeks (CON + CUMS), high fat diet (HFD) and high lipid feed for 9 weeks followed by CUMS for 4 weeks (HFD + CUMS) (n = 10 each). Open-field test was individually measured at baseline, week 9 and week 13. (1) Serum lipids: total cholesterol [(2.67 ± 0.04) mmol/L, (2.68 ± 0.02) mmol/L] and low density lipoprotein [(1.08 ± 0.03) mmol/L, (1.06 ± 0.01) mmol/L] of HFD and HFD + CUMS were both significantly higher than those of CON and CON + CUMS [(1.78 ± 0.12) mmol/L, (0.79 ± 0.04) mmol/L; (1.76 ± 0.09) mmol/L, (0.76 ± 0.06) mmol/L, all P Open-field test: at week 13, compared to CON rats, CON + CUMS rats exhibited enhanced locomotor activity during the first minute, reduced activity in the center squares and rearing, and increased the number of grooming and defecation (all P < 0.05). In comparison to the CON rats, a decrease in total squares in 5 min, central squares and peripheral squares was observed in HFD rats at week 13 (all P < 0.05). However, compared with HFD, CON, CON + CUMS rats, when high lipid feed for 9 weeks combined with depression, significant decrease activities in total squares in 5 min, central squares and peripheral squares were observed in HFD + CUMS rats at week 13. Besides these, the number of rearing was reduced, however, locomotor activity during the first minute and the number of grooming and defecation was significantly increased (all P < 0.001). Under uncontrolled hyperlipidemia, severe depressive symptoms will present more early once exposure to a series of chronic stressors followed by significant autonomic nervous dysfunctional symptoms.

  14. Pollination deficit in open-field tomato crops (Solanum lycopersicum L., Solanaceae in Rio de Janeiro state, Southeast Brazil

    Directory of Open Access Journals (Sweden)

    Maria Cristina Gaglianone

    2013-10-01

    Full Text Available More than 70% of world’s crops benefit from biotic pollination, and bees are their main pollinators. Despite the fact that some of these insects have been broadly studied, understanding the interactions between plant crops and their pollinators with a local scale approach is necessary when aiming to apply proper protective and management measures to pollinators and their respective crops. In this context, we analyzed the pollination status of open-field tomato crops (Solanum lycopersicum L., regarding fruit-set, visitation rate and the quality of fruits. We recorded the formation of fruits through spontaneous self-pollination and open-pollination, and the occurrence of pollinators in 24 areas of open-field tomato crops. We performed experiments of apomixis, spontaneous self-pollination, manual cross pollination and supplemental cross pollination (simulating the pollinator behavior in a greenhouse. The fruit quality was evaluated according to circumference, weight, volume and number of seeds. Higher production of fruits after open-pollination compared to spontaneous self-pollination indicates the importance of pollinators to increment productivity of S. lycopersicum in the study area. The circumference and the number of seeds from tomatoes of the greenhouse plantation did not differ between spontaneous self-pollination and the manual cross pollination. In the open-field crops the number of seeds was higher for fruits resulting from open-pollination. Our results indicate that the importance of bees is mainly related to the increase in fruit production, thus incrementing the productivity of tomato crops.

  15. Pollination deficit in open-field tomato crops (Solanum lycopersicum L., Solanaceae in Rio de Janeiro state, Southeast Brazil

    Directory of Open Access Journals (Sweden)

    Mariana Scaramussa Deprá

    2014-02-01

    Full Text Available More than 70% of world’s crops benefit from biotic pollination, and bees are their main pollinators. Despite the fact that some of these insects have been broadly studied, understanding the interactions between plant crops and their pollinators with a local scale approach is necessary when aiming to apply proper protective and management measures to pollinators and their respective crops. In this context, we analyzed the pollination status of open-field tomato crops (Solanum lycopersicum L., regarding fruit-set, visitation rate and the quality of fruits. We recorded the formation of fruits through spontaneous self-pollination and open-pollination, and the occurrence of pollinators in 24 areas of open-field tomato crops. We performed experiments of apomixis, spontaneous self-pollination, manual cross pollination and supplemental cross pollination (simulating the pollinator behavior in a greenhouse. The fruit quality was evaluated according to circumference, weight, volume and number of seeds. Higher production of fruits after open-pollination compared to spontaneous self-pollination indicates the importance of pollinators to increment productivity of S. lycopersicum in the study area. The circumference and the number of seeds from tomatoes of the greenhouse plantation did not differ between spontaneous self-pollination and the manual cross pollination. In the open-field crops the number of seeds was higher for fruits resulting from open-pollination. Our results indicate that the importance of bees is mainly related to the increase in fruit production, thus incrementing the productivity of tomato crops.

  16. Are voluntary wheel running and open-field behavior correlated in mice? Different answers from comparative and artificial selection approaches.

    Science.gov (United States)

    Careau, Vincent; Bininda-Emonds, Olaf R P; Ordonez, Genesis; Garland, Theodore

    2012-09-01

    Voluntary wheel running and open-field behavior are probably the two most widely used measures of locomotion in laboratory rodents. We tested whether these two behaviors are correlated in mice using two approaches: the phylogenetic comparative method using inbred strains of mice and an ongoing artificial selection experiment on voluntary wheel running. After taking into account the measurement error and phylogenetic relationships among inbred strains, we obtained a significant positive correlation between distance run on wheels and distance moved in the open-field for both sexes. Thigmotaxis was negatively correlated with distance run on wheels in females but not in males. By contrast, mice from four replicate lines bred for high wheel running did not differ in either distance covered or thigmotaxis in the open field as compared with mice from four non-selected control lines. Overall, results obtained in the selection experiment were generally opposite to those observed among inbred strains. Possible reasons for this discrepancy are discussed.

  17. Elimination of the geomagnetic field stimulates the proliferation of mouse neural progenitor and stem cells

    Directory of Open Access Journals (Sweden)

    Jing-Peng Fu

    2016-08-01

    Full Text Available Abstract Living organisms are exposed to the geomagnetic field (GMF throughout their lifespan. Elimination of the GMF, resulting in a hypogeomagnetic field (HMF, leads to central nervous system dysfunction and abnormal development in animals. However, the cellular mechanisms underlying these effects have not been identified so far. Here, we show that exposure to an HMF (<200 nT, produced by a magnetic field shielding chamber, promotes the proliferation of neural progenitor/stem cells (NPCs/NSCs from C57BL/6 mice. Following seven-day HMF-exposure, the primary neurospheres (NSs were significantly larger in size, and twice more NPCs/NSCs were harvested from neonatal NSs, when compared to the GMF controls. The self-renewal capacity and multipotency of the NSs were maintained, as HMF-exposed NSs were positive for NSC markers (Nestin and Sox2, and could differentiate into neurons and astrocyte/glial cells and be passaged continuously. In addition, adult mice exposed to the HMF for one month were observed to have a greater number of proliferative cells in the subventricular zone. These findings indicate that continuous HMF-exposure increases the proliferation of NPCs/NSCs, in vitro and in vivo. HMF-disturbed NPCs/NSCs production probably affects brain development and function, which provides a novel clue for elucidating the cellular mechanisms of the bio-HMF response.

  18. Comparative energy input–output and financial analyses of greenhouse and open field vegetables production in West Java, Indonesia

    International Nuclear Information System (INIS)

    Kuswardhani, Nita; Soni, Peeyush; Shivakoti, Ganesh P.

    2013-01-01

    This paper estimates energy consumption per unit floor area of greenhouse and open field for tomato, chili and lettuce production. Primary data were collected from 530 vegetable farmers during Jan–Dec, 2010 in West Java, Indonesia. Energy estimates were calculated from actual amount of inputs and outputs and corresponding conversion factors. Results reveal that the total input energy used in greenhouse (GH) production of tomato, chili (medium and high land) and lettuce were 47.62, 41.55, 58.84, and 24.54 GJ/ha respectively. Whereas, the requirement of total input energy for open field (OF) production of tomato, chili (medium and high land) and lettuce were 49.01, 41.04, 57.94 and 23.87 GJ/ha, respectively. The ratio of output to input energy was higher in greenhouse production (0.85, 0.45 and 0.49) than open field vegetable production (0.52, 0.175 and 0.186) for tomato, chili medium land and chili highland, respectively, but output–input ratio of lettuce open field production was twice as that of greenhouse vegetable production. Financial analysis revealed higher mean net returns from greenhouse vegetable production as 7043 $/ha (922–15,299 $/ha) when compared to 571 $/ha (44–1172 $/ha) from open field vegetable production. Among the greenhouse vegetables, tomato cultivation was the most profitable in terms of energy efficiency and financial productivity. - Highlights: ► Energy input–output analysis is carried out to compare vegetables production in greenhouse and open field. ► Tomato, Chili and Lettuce production in West Java, Indonesia. ► Economic analysis is conducted to compare the two production systems

  19. New variable stars discovered in the fields of three Galactic open clusters using the VVV survey

    Science.gov (United States)

    Palma, T.; Minniti, D.; Dékány, I.; Clariá, J. J.; Alonso-García, J.; Gramajo, L. V.; Ramírez Alegría, S.; Bonatto, C.

    2016-11-01

    This project is a massive near-infrared (NIR) search for variable stars in highly reddened and obscured open cluster (OC) fields projected on regions of the Galactic bulge and disk. The search is performed using photometric NIR data in the J-, H- and Ks- bands obtained from the Vista Variables in the Vía Láctea (VVV) Survey. We performed in each cluster field a variability search using Stetson's variability statistics to select the variable candidates. Later, those candidates were subjected to a frequency analysis using the Generalized Lomb-Scargle and the Phase Dispersion Minimization algorithms. The number of independent observations range between 63 and 73. The newly discovered variables in this study, 157 in total in three different known OCs, are classified based on their light curve shapes, periods, amplitudes and their location in the corresponding color-magnitude (J -Ks ,Ks) and color-color (H -Ks , J - H) diagrams. We found 5 possible Cepheid stars which, based on the period-luminosity relation, are very likely type II Cepheids located behind the bulge. Among the newly discovered variables, there are eclipsing binaries, δ Scuti, as well as background RR Lyrae stars. Using the new version of the Wilson & Devinney code as well as the "Physics Of Eclipsing Binaries" (PHOEBE) code, we analyzed some of the best eclipsing binaries we discovered. Our results show that these studied systems turn out to be ranging from detached to double-contact binaries, with low eccentricities and high inclinations of approximately 80°. Their surface temperatures range between 3500 K and 8000 K.

  20. Subchronic Oral Bromocriptine Methanesulfonate Enhances Open Field Novelty-Induced Behavior and Spatial Memory in Male Swiss Albino Mice

    OpenAIRE

    Onaolapo, Olakunle James; Onaolapo, Adejoke Yetunde

    2012-01-01

    This study set out to assess the neurobehavioral effects of subchronic, oral bromocriptine methanesulfonate using the open field and the Y-maze in healthy male mice. Sixty adult Swiss albino mice were assigned into three groups. Controls received normal saline, while test groups received bromocriptine methanesulfonate at 2.5 and 5 mg/kg/day, respectively, for a period of 21 days. Neurobehavioral tests were carried out on days 1 and 21 after administration. Open field assessment on day 1 after...

  1. Using possibilities of some agricultural wastes in open-field banana cultivation

    Directory of Open Access Journals (Sweden)

    Mehmet ÖTEN

    2016-06-01

    Full Text Available Usage of farmyard manure is the one of the major factors to increase production cost in banana cultivation. Besides increasing the production costs, other disadvantages of farmyard manure are playing active role on carrying diseases and pests and also difficulty in obtaining. Due to the stated disadvantages, the use farmyard manure of banana farmers is decreasing. Therefore, we need alternative ways to increase the organic matter capacity of the soil. The effects of alternative applications to farmyard manure, namely banana waste and mushroom compost were investigated. The objective of the study was to evaluate effects of these applications on some morphological properties (plant height, plant circumference and number of leaves, yield (number of hands, number of fingers, bunch weight, finger weight and length and quality properties (flesh/skin ratio, total soluble solids matter, sugars etc. under open-field banana cultivation. The experiment was conducted in Kargıcak location of Alanya in randomized complete block design (RCBD with 3 replications. Experimental results revealed that using of farmyard manure and waste treatments positively affected the yield parameters like the number of hands and fingers, finger length, finger weight and bunch weight. On the other hand, treatments did not have a statistically significant effect on fruit quality parameters like soluble solids content, titratable acidity, pH and ash.

  2. Advances in continuum kinetic and gyrokinetic simulations of turbulence on open-field line geometries

    Science.gov (United States)

    Hakim, Ammar; Shi, Eric; Juno, James; Bernard, Tess; Hammett, Greg

    2017-10-01

    For weakly collisional (or collisionless) plasmas, kinetic effects are required to capture the physics of micro-turbulence. We have implemented solvers for kinetic and gyrokinetic equations in the computational plasma physics framework, Gkeyll. We use a version of discontinuous Galerkin scheme that conserves energy exactly. Plasma sheaths are modeled with novel boundary conditions. Positivity of distribution functions is maintained via a reconstruction method, allowing robust simulations that continue to conserve energy even with positivity limiters. We have performed a large number of benchmarks, verifying the accuracy and robustness of our code. We demonstrate the application of our algorithm to two classes of problems (a) Vlasov-Maxwell simulations of turbulence in a magnetized plasma, applicable to space plasmas; (b) Gyrokinetic simulations of turbulence in open-field-line geometries, applicable to laboratory plasmas. Supported by the Max-Planck/Princeton Center for Plasma Physics, the SciDAC Center for the Study of Plasma Microturbulence, and DOE Contract DE-AC02-09CH11466.

  3. Pharmacological differences between memory consolidation of habituation to an open field and inhibitory avoidance learning

    Directory of Open Access Journals (Sweden)

    Vianna M.R.M.

    2001-01-01

    Full Text Available Rats implanted bilaterally with cannulae in the CA1 region of the dorsal hippocampus or the entorhinal cortex were submitted to either a one-trial inhibitory avoidance task, or to 5 min of habituation to an open field. Immediately after training, they received intrahippocampal or intraentorhinal 0.5-µl infusions of saline, of a vehicle (2% dimethylsulfoxide in saline, of the glutamatergic N-methyl-D-aspartate (NMDA receptor antagonist 2-amino-5-phosphono pentanoic acid (AP5, of the protein kinase A inhibitor Rp-cAMPs (0.5 µg/side, of the calcium-calmodulin protein kinase II inhibitor KN-62, of the dopaminergic D1 antagonist SCH23390, or of the mitogen-activated protein kinase kinase inhibitor PD098059. Animals were tested in each task 24 h after training. Intrahippocampal KN-62 was amnestic for habituation; none of the other treatments had any effect on the retention of this task. In contrast, all of them strongly affected memory of the avoidance task. Intrahippocampal Rp-cAMPs, KN-62 and AP5, and intraentorhinal Rp-cAMPs, KN-62, PD098059 and SCH23390 caused retrograde amnesia. In view of the known actions of the treatments used, the present findings point to important biochemical differences in memory consolidation processes of the two tasks.

  4. Investigating Alfvénic wave propagation in coronal open-field regions

    Science.gov (United States)

    Morton, R. J.; Tomczyk, S.; Pinto, R.

    2015-01-01

    The physical mechanisms behind accelerating solar and stellar winds are a long-standing astrophysical mystery, although recent breakthroughs have come from models invoking the turbulent dissipation of Alfvén waves. The existence of Alfvén waves far from the Sun has been known since the 1970s, and recently the presence of ubiquitous Alfvénic waves throughout the solar atmosphere has been confirmed. However, the presence of atmospheric Alfvénic waves does not, alone, provide sufficient support for wave-based models; the existence of counter-propagating Alfvénic waves is crucial for the development of turbulence. Here, we demonstrate that counter-propagating Alfvénic waves exist in open coronal magnetic fields and reveal key observational insights into the details of their generation, reflection in the upper atmosphere and outward propagation into the solar wind. The results enhance our knowledge of Alfvénic wave propagation in the solar atmosphere, providing support and constraints for some of the recent Alfvén wave turbulence models. PMID:26213234

  5. Cerebellar dentate nuclei lesions reduce motivation in appetitive operant conditioning and open field exploration.

    Science.gov (United States)

    Bauer, David J; Kerr, Abigail L; Swain, Rodney A

    2011-02-01

    Recently identified pathways from the dentate nuclei of the cerebellum to the rostral cerebral cortex via the thalamus suggest a cerebellar role in frontal and prefrontal non-motor functioning. Disturbance of cerebellar morphology and connectivity, particularly involving these cerebellothalamocortical (CTC) projections, has been implicated in motivational and cognitive deficits. The current study explored the effects of CTC disruption on motivation in male Long Evans rats. The results of two experiments demonstrate that electrolytic lesions of the cerebellar dentate nuclei lower breaking points on an operant conditioning progressive ratio schedule and decrease open field exploration compared to sham controls. Changes occurred in the absence of motor impairment, assessed via lever pressing frequency and rotarod performance. Similar elevated plus maze performances between lesioned and sham animals indicated that anxiety did not influence task performance. Our results demonstrate hedonic and purposive motivational reduction and suggest a CTC role in global motivational processes. These implications are discussed in terms of psychiatric disorders such as schizophrenia and autism, in which cerebellar damage and motivational deficits often present concomitantly. Copyright © 2010 Elsevier Inc. All rights reserved.

  6. Inter operability of smart field devices on an open field-bus: from laboratory tests to on-site applications

    International Nuclear Information System (INIS)

    Piguet, M.; Favennec, J.M.

    1997-01-01

    The paper presents a field trial held in EDF's R and D laboratories concerning smart field instruments (sensors, I/O modules, transmitters) operating on the WorldFIP field-bus. The trial put into operation a supervisory control and data acquisition (SCADA) system on the field-bus with available industrial field devices and software tools. The field trial enables EDF's teams to address the inter-operability issue regarding smart field devices and to prepare the forthcoming step from analog to fully digital measurement technology by evaluating new services and higher performances provided. Possible architectures for process control and on-site testing purposes have been identified. A first application for a flow-measuring rig is under way. It implements a WorldFIP field-bus based DCS with FIP/HART multiplexers, FIP and HART smart devices (sensors and actuators) and a field management system. (authors)

  7. Behavior in the open field predicts the number of KCl-induced cortical spreading depressions in rats.

    Science.gov (United States)

    Bogdanov, Volodymyr Borysovych; Bogdanova, Olena Viktorivna; Koulchitsky, Stanislav Vladimirovich; Chauvel, Virginie; Multon, Sylvie; Makarchuk, Mykola Yukhymovych; Brennan, Kevin Christopher; Renshaw, Perry Franklin; Schoenen, Jean

    2013-01-01

    Anxiety disorders are known to be comorbid with migraine, and cortical spreading depression (CSD) is the most likely cause of the migraine aura. To search for possible correlations between susceptibility to CSD and anxiety we used the open field test in male Sprague-Dawley rats chronically treated with the preventive anti-migraine drugs valproate or riboflavin. Animals avoiding the central area of the open field chamber and those with less exploratory activity (i.e. rearing) were considered more anxious. After 4 weeks of treatment CSDs were elicited by application of 1M KCl over the occipital cortex and the number of CSDs occurring over a 2h period was compared to the previously assessed open field behavior. Higher anxiety-like behavior was significantly correlated with a higher frequency of KCl-induced CSDs. In saline-treated animals, fewer rearings were found in animals with more frequent CSDs (R=-1.00). The duration of ambulatory episodes in the open field center correlated negatively with number of CSDs in the valproate group (R=-0.83; popen field center in both groups (R=-0.75; p<0.05 and R=-0.58; p<0.1 respectively). These results suggest that anxiety symptoms are associated with susceptibility to CSD and might explain why it can be an aggravating factor in migraine with aura. Copyright © 2012 Elsevier B.V. All rights reserved.

  8. BSDWormer; an Open Source Implementation of a Poisson Wavelet Multiscale Analysis for Potential Fields

    Science.gov (United States)

    Horowitz, F. G.; Gaede, O.

    2014-12-01

    Wavelet multiscale edge analysis of potential fields (a.k.a. "worms") has been known since Moreau et al. (1997) and was independently derived by Hornby et al. (1999). The technique is useful for producing a scale-explicit overview of the structures beneath a gravity or magnetic survey, including establishing the location and estimating the attitude of surface features, as well as incorporating information about the geometric class (point, line, surface, volume, fractal) of the underlying sources — in a fashion much like traditional structural indices from Euler solutions albeit with better areal coverage. Hornby et al. (2002) show that worms form the locally highest concentration of horizontal edges of a given strike — which in conjunction with the results from Mallat and Zhong (1992) induces a (non-unique!) inversion where the worms are physically interpretable as lateral boundaries in a source distribution that produces a close approximation of the observed potential field. The technique has enjoyed widespread adoption and success in the Australian mineral exploration community — including "ground truth" via successfully drilling structures indicated by the worms. Unfortunately, to our knowledge, all implementations of the code to calculate the worms/multiscale edges (including Horowitz' original research code) are either part of commercial software packages, or have copyright restrictions that impede the use of the technique by the wider community. The technique is completely described mathematically in Hornby et al. (1999) along with some later publications. This enables us to re-implement from scratch the code required to calculate and visualize the worms. We are freely releasing the results under an (open source) BSD two-clause software license. A git repository is available at . We will give an overview of the technique, show code snippets using the codebase, and present visualization results for example datasets (including the Surat basin of Australia

  9. Potentiation by substance P of contractions of the isolated vas deferens of the mouse elicited by electric field stimulation and by drugs

    International Nuclear Information System (INIS)

    Blackwell, M.; James, T.A.; Starr, M.S.

    1978-01-01

    Isolated vasa deferentia from the mouse were opened longitudinally and suspended in Krebs solution at 37 0 C in an organ bath. Contractions of the muscle were elicited by electric field stimulation, noradrenaline (10 -6 M) and acetylcholine (10 -6 M). Continued transmural stimulation evoked a biphasic response comprising a rapid twitch followed by about 10 s later by a smaller, sustained rise in muscle tone. The amplitudes of nerve-mediated and drug-induced responses were considerably potentiated by substances P (SP) in the dose range 10 -12 to 10 -7 M. Higher concentrations of SP were directly spasmogenic. The sensitizing property of SP was dose-dependent and was usually well maintained, but always disappeared quickly on washing the preparation. In some experiments SP facilitated the twitch, but not the subsequent phase of the electrically-induced contraction or the response to externally applied noradrenaline. Phentolamine (10 -6 M) failed to block this effect of SP, but itself potentiated the nerve-mediated twitch, and completely abolished the sustained secondary contraction. Desmethylimipramine (10 -6 M) enhanced the delayed contraction but not the immediate contraction. The uptake of tritiated noradrenaline (3 x 10 -7 M) by vasa was inhibited by desmethylimipramine (10 -6 M) and increased by nialamide (3 x 10 -5 M), but was not modified by SP (10 -6 M). Nerve-mediated release of accumulated radioactivity was accelerated by phentolamine, but not by SP or desmethylimipramine. These findings suggest that SP sensitizes the muscle cells to depolarizing stimuli but that it has no facilitatory effect on sympathetic neural elements. (author)

  10. Genetic diversity and genetic structure of the striped field mouse Apodemus agrarius coreae (Muridae, Rodentia) in Korea.

    Science.gov (United States)

    Kim, Hye Ri; Park, Yung Chul

    2015-11-10

    The aim of this study was to investigate the genetic diversity and genetic structure of the striped field mouse Apodemus agrarius coreae in Korea. The Korean A. a. coreae is characterized by high levels of haplotype diversity (Hd=0.967) and low levels of nucleotide diversity (π=0.00683). Haplogroup 1 is well separated from the haplotypes of the neighboring regions of the Korean Peninsula, while the other haplogroups are closely related to those from the Russian Far East. Thus, further investigations are required to confirm the validity of the subspecies status of A. a. coreae by implementing additional morphological characters as well as genetic data from the populations present in the Korean Peninsula and its neighboring countries. Haplogroup 1 includes most Korean haplotypes and forms a star-like haplotype network structure, which reveals relatively low levels of sequence divergence and high frequency of unique mutations (only few mutations are shared in most of the haplotype nodes). The results indicate that the haplotypes of Haplogroup 1 might have experienced population expansion since their migration into Korea, which was further corroborated with negative results of neutrality tests for Korean population of A. a. coreae. Copyright © 2015. Published by Elsevier B.V.

  11. Electrolytic analogue study of the effect of openings and surrounds of various permeabilities on the performance of field drainage pipes

    NARCIS (Netherlands)

    Dierickx, W.

    1980-01-01

    The effect of various openings and surrounds of various permeabilities on the performance of field drainage pipes was studied by means of an electrolytic analogue. The results obtained were compared with these of analytical solutions. Rather simple and sufficiently accurate solutions exist to

  12. Caffeine and sleep-deprivation mediated changes in open-field behaviours, stress response and antioxidant status in mice

    Directory of Open Access Journals (Sweden)

    J. Olakunle Onaolapo

    2016-07-01

    Conclusion: Repeated caffeine consumption and/or acute sleep-deprivation led to significant changes in pattern of open-field behaviour and stress/antioxidant response in mice. Responses seen in the study are probably due to modulatory effects of caffeine on the total body response to stressful stimuli.

  13. Dosimetric and geometric evaluation of an open low-field magnetic resonance simulator for radiotherapy treatment planning of brain tumours

    DEFF Research Database (Denmark)

    Kristensen, B.H.; Laursen, F.J.; Logager, V.

    2008-01-01

    Background and purpose: Magnetic resonance (MR) imaging is superior to computed tomography (CT) in radiotherapy of brain tumours. In this study an open low-field MR-simulator is evaluated in order to eliminate the cost of and time spent on additional CT scanning. Materials and methods: Eleven...

  14. Electroantennogram responses of tsetse flies (Glossina pallidipes) to host odours in an open field and riverine woodland

    NARCIS (Netherlands)

    Voskamp, K.E; den Otter, C.J; Noorman, N

    The present study was initiated to gain insight into the way in which tsetse flies (Glossina spp.) sense odours at different locations in odour plumes in both an open field and a wooded area. We recorded the antennal responses (EAGs) from stationary living female G. pallidipes 15 m upwind and at

  15. The effects of gonadectomy and binge-like ethanol exposure during adolescence on open field behaviour in adult male rats.

    Science.gov (United States)

    Yan, Wensheng; Kang, Jie; Zhang, Guoliang; Li, Shuangcheng; Kang, Yunxiao; Wang, Lei; Shi, Geming

    2015-09-14

    Binge drinking ethanol exposure during adolescence can lead to long-term neurobehavioural damage. It is not known whether the pubertal surge in testosterone that occurs during adolescence might impact the neurobehavioural effects of early ethanol exposure in adult animals. We examined this hypothesis by performing sham or gonadectomy surgeries on Sprague-Dawley rats around postnatal day (P) 23. From P28-65,the rats were administered 3.0g/kg ethanol using a binge-like model of exposure. Dependent measurements included tests of open field behaviour, blood ethanol concentrations, and testosterone levels. As adults, significant decreases in open field activity were observed in the GX rats. The open field behaviour of the GX rats was restored after testosterone administration. Binge-like ethanol exposure altered most of the parameters of the open field behaviour, suggestive of alcohol-induced anxiety, but rats treated with alcohol in combination with gonadectomy showed less motor behaviour and grooming behaviour and an increase in immobility, suggesting ethanol-induced depression. These results indicated that testosterone is required for ethanol-induced behavioural changes and that testicular hormones are potent stimulators of ethanol-induced behaviours. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  16. Predicting Canopy Temperatures without and with Infrared Heating of Open-Field Plots and Energy Requirements for such Infrared Heating

    Science.gov (United States)

    In order to determine the likely effect of global warming on agricultural productivity while avoiding experimental artifacts, there is a need to conduct warming research under conditions as representative as possible of future open fields, i.e., temperature free-air controlled enhancement (T-FACE) e...

  17. Quantifying over-activity in bipolar and schizophrenia patients in a human open field paradigm.

    Science.gov (United States)

    Perry, William; Minassian, Arpi; Henry, Brook; Kincaid, Meegin; Young, Jared W; Geyer, Mark A

    2010-06-30

    It has been suggested that a cardinal symptom of mania is over-activity and exaggerated goal-directed behavior. Nevertheless, few attempts have been made to quantify this behavior objectively in a laboratory environment. Having a methodology to assess over-activity reliably might be useful in distinguishing manic bipolar disorder (BD) from schizophrenia (SCZ) during highly activated states. In the current study, quantifiable measures of object interaction were assessed using a multivariate approach. Additionally, symptom correlates of over-activity were assessed. Patients admitted to an acute care psychiatric hospital for either BD with mania or SCZ (paranoid and non-paranoid subtypes) as well as non-patient comparison (NC) participants were assessed in an open field setting referred to as the human Behavioral Pattern Monitor (hBPM). Activity and interactions with novel and engaging objects were recorded for 15min via a concealed video camera and rated for exploratory behavior. Both BD and SCZ patients spent more time near the objects and exhibited more overall walking compared to NC. In contrast, BD patients exhibited greater physical contact with objects (number of object interactions and time spent with objects) relative to SCZ patients or NC participants, as well as more perseverative and socially disinhibited behaviors, indicating a unique pattern of over-activity and goal-directed behavior. Further analyses revealed a distinction between SCZ patients according to their subtype. The current study extends our methodology for quantifying exploration and over-activity in a controlled laboratory setting and aids in assessing the overlap and distinguishing characteristics of BD and SCZ.

  18. Analysis of the trajectory of Drosophila melanogaster in a circular open field arena.

    Science.gov (United States)

    Valente, Dan; Golani, Ilan; Mitra, Partha P

    2007-10-24

    Obtaining a complete phenotypic characterization of a freely moving organism is a difficult task, yet such a description is desired in many neuroethological studies. Many metrics currently used in the literature to describe locomotor and exploratory behavior are typically based on average quantities or subjectively chosen spatial and temporal thresholds. All of these measures are relatively coarse-grained in the time domain. It is advantageous, however, to employ metrics based on the entire trajectory that an organism takes while exploring its environment. To characterize the locomotor behavior of Drosophila melanogaster, we used a video tracking system to record the trajectory of a single fly walking in a circular open field arena. The fly was tracked for two hours. Here, we present techniques with which to analyze the motion of the fly in this paradigm, and we discuss the methods of calculation. The measures we introduce are based on spatial and temporal probability distributions and utilize the entire time-series trajectory of the fly, thus emphasizing the dynamic nature of locomotor behavior. Marginal and joint probability distributions of speed, position, segment duration, path curvature, and reorientation angle are examined and related to the observed behavior. The measures discussed in this paper provide a detailed profile of the behavior of a single fly and highlight the interaction of the fly with the environment. Such measures may serve as useful tools in any behavioral study in which the movement of a fly is an important variable and can be incorporated easily into many setups, facilitating high-throughput phenotypic characterization.

  19. Analysis of the trajectory of Drosophila melanogaster in a circular open field arena.

    Directory of Open Access Journals (Sweden)

    Dan Valente

    Full Text Available BACKGROUND: Obtaining a complete phenotypic characterization of a freely moving organism is a difficult task, yet such a description is desired in many neuroethological studies. Many metrics currently used in the literature to describe locomotor and exploratory behavior are typically based on average quantities or subjectively chosen spatial and temporal thresholds. All of these measures are relatively coarse-grained in the time domain. It is advantageous, however, to employ metrics based on the entire trajectory that an organism takes while exploring its environment. METHODOLOGY/PRINCIPAL FINDINGS: To characterize the locomotor behavior of Drosophila melanogaster, we used a video tracking system to record the trajectory of a single fly walking in a circular open field arena. The fly was tracked for two hours. Here, we present techniques with which to analyze the motion of the fly in this paradigm, and we discuss the methods of calculation. The measures we introduce are based on spatial and temporal probability distributions and utilize the entire time-series trajectory of the fly, thus emphasizing the dynamic nature of locomotor behavior. Marginal and joint probability distributions of speed, position, segment duration, path curvature, and reorientation angle are examined and related to the observed behavior. CONCLUSIONS/SIGNIFICANCE: The measures discussed in this paper provide a detailed profile of the behavior of a single fly and highlight the interaction of the fly with the environment. Such measures may serve as useful tools in any behavioral study in which the movement of a fly is an important variable and can be incorporated easily into many setups, facilitating high-throughput phenotypic characterization.

  20. Relationship between visual field progression and baseline refraction in primary open-angle glaucoma.

    Science.gov (United States)

    Naito, Tomoko; Yoshikawa, Keiji; Mizoue, Shiro; Nanno, Mami; Kimura, Tairo; Suzumura, Hirotaka; Umeda, Yuzo; Shiraga, Fumio

    2016-01-01

    To analyze the relationship between visual field (VF) progression and baseline refraction in Japanese patients with primary open-angle glaucoma (POAG) including normal-tension glaucoma. In this retrospective study, the subjects were patients with POAG who had undergone VF tests at least ten times with a Humphrey Field Analyzer (Swedish interactive thresholding algorithm standard, Central 30-2 program). VF progression was defined as a significantly negative value of mean deviation (MD) slope at the final VF test. Multivariate logistic regression models were applied to detect an association between MD slope deterioration and baseline refraction. A total of 156 eyes of 156 patients were included in this analysis. Significant deterioration of MD slope was observed in 70 eyes of 70 patients (44.9%), whereas no significant deterioration was evident in 86 eyes of 86 patients (55.1%). The eyes with VF progression had significantly higher baseline refraction compared to those without apparent VF progression (-1.9±3.8 diopter [D] vs -3.5±3.4 D, P=0.0048) (mean ± standard deviation). When subject eyes were classified into four groups by the level of baseline refraction applying spherical equivalent (SE): no myopia (SE > -1D), mild myopia (-1D ≥ SE > -3D), moderate myopia (-3D ≥ SE > -6D), and severe myopia (-6D ≥ SE), the Cochran-Armitage trend analysis showed a decreasing trend in the proportion of MD slope deterioration with increasing severity of myopia (P=0.0002). The multivariate analysis revealed that baseline refraction (P=0.0108, odds ratio [OR]: 1.13, 95% confidence interval [CI]: 1.03-1.25) and intraocular pressure reduction rate (P=0.0150, OR: 0.97, 95% CI: 0.94-0.99) had a significant association with MD slope deterioration. In the current analysis of Japanese patients with POAG, baseline refraction was a factor significantly associated with MD slope deterioration as well as intraocular pressure reduction rate. When baseline refraction was classified into

  1. The stimulatory effects of caffeine with oseltamivir (Tamiflu) on light-dark behavior and open-field behavior in mice.

    Science.gov (United States)

    Uchiyama, Hidemori; Toda, Akihisa; Imoto, Masumi; Nishimura, Satoko; Kuroki, Hiroaki; Soeda, Shinji; Shimeno, Hiroshi; Watanabe, Shigenori; Eyanagi, Reiko

    2010-01-22

    Abnormal behaviors and death associated with the use of oseltamivir (Tamiflu) have emerged as a major issue in influenza patients taking the drug. Here, we investigated the mechanisms underlying the effects of oseltamivir on the behavior of mice using light-dark and open-field preference tests. Oseltamivir (75 and 150 mg/kg, intraperitoneally (i.p.)) alone affected neither time spent in the open area in the light-dark preference test nor ambulation in the open-field test at 2h post-injection. However, a non-selective adenosine A(1)/A(2) receptor antagonist, caffeine (10mg/kg, i.p.) in combination with oseltamivir (150 mg/kg, i.p.) increased time spent in the open area in the light-dark preference test. This enhancement was not inhibited by a benzodiazepine receptor antagonist, flumazenil (10-20mg/kg, subcutaneously (s.c.)). Enhancement of ambulation in the open-field test was also observed when caffeine (10mg/kg, i.p.) was combined with oseltamivir (150 mg/kg, i.p.). This enhancement was inhibited by a dopamine D(2) receptor antagonist, haloperidol (0.1mg/kg, s.c.). Furthermore, an adenosine A(2) receptor antagonist, SCH58261 (3mg/kg, i.p.) in combination with oseltamivir (150 mg/kg, i.p.) increased ambulation in the open-field test, while an adenosine A(1) receptor antagonist, DPCPX (1-3mg/kg, i.p.) did not. These findings suggest that the actions of oseltamivir may involve the dopamine and adenosine systems. Our findings suggest that due to the interaction between central blockade of adenosine A(2) receptors by caffeine, and oseltamivir-induced behavioral changes, patients being treated with oseltamivir should be closely monitored. (c) 2009 Elsevier Ireland Ltd. All rights reserved.

  2. Priority Fields of Teachers' Professional Development in Terms of Open Education Worldwide

    Science.gov (United States)

    Avshenyuk, Nataliya

    2016-01-01

    The article is devoted to the problem of teachers' professional development within the concept of "open educational resources". The author analyzes the project "Massive Open Online Courses" (MOOC) as one of the modern achievements in the area of information and communication technology (ICT) for the development of adult…

  3. Attracted to open access journals: A bibliometric author analysis in the field of biology

    DEFF Research Database (Denmark)

    Faber Frandsen, Tove

    2009-01-01

    Purpose - Scholars from developing countries have limited access to research publications due to expensive subscription costs. However, the open access movement is challenging the constraint to access. Consequently, researchers in developing countries are often mentioned as major recipients...... of the benefits when advocating open access (OA). One of the implications of that argument is that authors from developing countries are more likely to perceive open access positively than authors from developed countries. The present study aims to investigate the use of open access by researchers from developing...... countries and is thus a supplement to the existing author surveys and interviews. Design/methodology/approach - Bibliometric analyses of both publishing behaviour and citing behaviour in relation to OA publishing provides evidence of the impact of open access on developing countries. Findings - The results...

  4. Evaluation Of Open, Wedge Filtered And Half Block Profile For Single And Plan Parallel Field For 60Co Teletherapy Unit

    International Nuclear Information System (INIS)

    Heru-Prasetio; Nasukha; Soejoko, Djarwani S

    2003-01-01

    TPS shall be evaluated with experimental data before it is used for patient treatment. This experiment was performed using small water phantom, at the depth of 10 cm, SSD technique for single beam and 16 cm, SAD technique for plan parallel beam. Measuring device used in this experiment is Farmer 2571 detector. It was found differences between experiment and TPS iSis are not significant. Single field experiment and TPS differences of 0.6%, 3.6% and 0.1% for open, wedge filter and half-blocked field, for plan parallel experiment and TPS differences are 2.1%, 2% and 2.4% for open, wedge filter and half-blocked field. (author)

  5. Ultralow field emission from thinned, open-ended, and defected carbon nanotubes by using microwave hydrogen plasma processing

    Energy Technology Data Exchange (ETDEWEB)

    Deng, Jian-Hua, E-mail: jhdeng1983@163.com [College of Physics and Materials Science, Tianjin Normal University, Tianjin 300387 (China); Cheng, Lin; Wang, Fan-Jie; Yu, Bin; Li, Guo-Zheng; Li, De-Jun [College of Physics and Materials Science, Tianjin Normal University, Tianjin 300387 (China); Cheng, Guo-An [Key Laboratory of Beam Technology and Material Modification of Ministry of Education, Beijing Normal University, Beijing 100875 (China)

    2015-01-01

    Graphical abstract: Thinned, open-ended, and defected carbon nanotubes were prepared by using hydrogen plasma processing. The processed carbon nanotubes have far better field emission performance than that of the pristine ones. - Highlights: • CVD prepared CNT arrays were processed by microwave hydrogen plasma. • Thinned, open-ended, and defected CNTs were obtained. • Processed CNTs have far better field emission performance than the pristine ones. • Processed CNTs have applicable emission stability after being perfectly aged. - Abstract: Ultralow field emission is achieved from carbon nanotubes (CNTs) by using microwave hydrogen plasma processing. After the processing, typical capped CNT tips are removed, with thinned, open-ended, and defected CNTs left. Structural analyses indicate that the processed CNTs have more SP{sup 3}-hybridized defects as compared to the pristine ones. The morphology of CNTs can be readily controlled by adjusting microwave powers, which change the shape of CNTs by means of hydrogen plasma etching. Processed CNTs with optimal morphology are found to have an ultralow turn-on field of 0.566 V/μm and threshold field of 0.896 V/μm, much better than 0.948 and 1.559 V/μm of the as-grown CNTs, respectively. This improved FE performance is ascribed to the structural changes of CNTs after the processing. The thinned and open-ended shape of CNTs can facilitate electron tunneling through barriers and additionally, the increased defects at tube walls can serve as new active emission sites. Furthermore, our plasma processed CNTs exhibit excellent field emission stability at a large emission current density of 10.36 mA/cm{sup 2} after being perfectly aged, showing promising prospects in applications as high-performance vacuum electron sources.

  6. LOW-MASS PLANETS IN PROTOPLANETARY DISKS WITH NET VERTICAL MAGNETIC FIELDS: THE PLANETARY WAKE AND GAP OPENING

    Energy Technology Data Exchange (ETDEWEB)

    Zhu Zhaohuan; Stone, James M.; Rafikov, Roman R., E-mail: zhzhu@astro.princeton.edu, E-mail: jstone@astro.princeton.edu, E-mail: rrr@astro.princeton.edu [Department of Astrophysical Sciences, Princeton University, Princeton, NJ, 08544 (United States)

    2013-05-10

    Some regions in protoplanetary disks are turbulent, while some regions are quiescent (e.g. the dead zone). In order to study how planets open gaps in both inviscid hydrodynamic disk (e.g. the dead zone) and the disk subject to magnetorotational instability (MRI), we carried out both shearing box two-dimensional inviscid hydrodynamical simulations and three-dimensional unstratified magnetohydrodynamical (MHD) simulations (having net vertical magnetic fields) with a planet at the box center. We found that, due to the nonlinear wave steepening, even a low mass planet can open gaps in both cases, in contradiction to the ''thermal criterion'' for gap opening. In order to understand if we can represent the MRI turbulent stress with the viscous {alpha} prescription for studying gap opening, we compare gap properties in MRI-turbulent disks to those in viscous HD disks having the same stress, and found that the same mass planet opens a significantly deeper and wider gap in net vertical flux MHD disks than in viscous HD disks. This difference arises due to the efficient magnetic field transport into the gap region in MRI disks, leading to a larger effective {alpha} within the gap. Thus, across the gap, the Maxwell stress profile is smoother than the gap density profile, and a deeper gap is needed for the Maxwell stress gradient to balance the planetary torque density. Comparison with previous results from net toroidal flux/zero flux MHD simulations indicates that the magnetic field geometry plays an important role in the gap opening process. We also found that long-lived density features (termed zonal flows) produced by the MRI can affect planet migration. Overall, our results suggest that gaps can be commonly produced by low mass planets in realistic protoplanetary disks, and caution the use of a constant {alpha}-viscosity to model gaps in protoplanetary disks.

  7. LOW-MASS PLANETS IN PROTOPLANETARY DISKS WITH NET VERTICAL MAGNETIC FIELDS: THE PLANETARY WAKE AND GAP OPENING

    International Nuclear Information System (INIS)

    Zhu Zhaohuan; Stone, James M.; Rafikov, Roman R.

    2013-01-01

    Some regions in protoplanetary disks are turbulent, while some regions are quiescent (e.g. the dead zone). In order to study how planets open gaps in both inviscid hydrodynamic disk (e.g. the dead zone) and the disk subject to magnetorotational instability (MRI), we carried out both shearing box two-dimensional inviscid hydrodynamical simulations and three-dimensional unstratified magnetohydrodynamical (MHD) simulations (having net vertical magnetic fields) with a planet at the box center. We found that, due to the nonlinear wave steepening, even a low mass planet can open gaps in both cases, in contradiction to the ''thermal criterion'' for gap opening. In order to understand if we can represent the MRI turbulent stress with the viscous α prescription for studying gap opening, we compare gap properties in MRI-turbulent disks to those in viscous HD disks having the same stress, and found that the same mass planet opens a significantly deeper and wider gap in net vertical flux MHD disks than in viscous HD disks. This difference arises due to the efficient magnetic field transport into the gap region in MRI disks, leading to a larger effective α within the gap. Thus, across the gap, the Maxwell stress profile is smoother than the gap density profile, and a deeper gap is needed for the Maxwell stress gradient to balance the planetary torque density. Comparison with previous results from net toroidal flux/zero flux MHD simulations indicates that the magnetic field geometry plays an important role in the gap opening process. We also found that long-lived density features (termed zonal flows) produced by the MRI can affect planet migration. Overall, our results suggest that gaps can be commonly produced by low mass planets in realistic protoplanetary disks, and caution the use of a constant α-viscosity to model gaps in protoplanetary disks.

  8. Increased occurrence of pesticide residues on crops grown in protected environments compared to crops grown in open field conditions.

    Science.gov (United States)

    Allen, Gina; Halsall, Crispin J; Ukpebor, Justina; Paul, Nigel D; Ridall, Gareth; Wargent, Jason J

    2015-01-01

    Crops grown under plastic-clad structures or in greenhouses may be prone to an increased frequency of pesticide residue detections and higher concentrations of pesticides relative to equivalent crops grown in the open field. To test this we examined pesticide data for crops selected from the quarterly reports (2004-2009) of the UK's Pesticide Residue Committee. Five comparison crop pairs were identified whereby one crop of each pair was assumed to have been grown primarily under some form of physical protection ('protected') and the other grown primarily in open field conditions ('open'). For each pair, the number of detectable pesticide residues and the proportion of crop samples containing pesticides were statistically compared (n=100 s samples for each crop). The mean concentrations of selected photolabile pesticides were also compared. For the crop pairings of cabbage ('open') vs. lettuce ('protected') and 'berries' ('open') vs. strawberries ('protected') there was a significantly higher number of pesticides and proportion of samples with multiple residues for the protected crops. Statistically higher concentrations of pesticides, including cypermethrin, cyprodinil, fenhexamid, boscalid and iprodione were also found in the protected crops compared to the open crops. The evidence here demonstrates that, in general, the protected crops possess a higher number of detectable pesticides compared to analogous crops grown in the open. This may be due to different pesticide-use regimes, but also due to slower rates of pesticide removal in protected systems. The findings of this study raise implications for pesticide management in protected-crop systems. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. MR arthrography in chondromalacia patellae diagnosis on a low-field open magnet system.

    Science.gov (United States)

    Harman, Mustafa; Ipeksoy, Umit; Dogan, Ali; Arslan, Halil; Etlik, Omer

    2003-01-01

    The purpose of this study was to compare the diagnostic efficacy conventional MRI and MR arthrography (MRA) in the diagnosis of chondromalacia patella (CP) on a low-field open magnet system (LFOMS), correlated with arthroscopy. Forty-two patients (50 knees) with pain in the anterior part of the knee were prospectively examined with LFOMS, including T1-weighted, proton density-weighted and T2-weighted sequences. All were also examined T1-weighted MRI after intraarticular injection of dilue gadopentetate dimeglumine. Two observers, who reached a consensus interpretation, evaluated each imaging technique independently. Thirty-six of the 50 facets examined had chondromalacia shown by arthroscopy, which was used as the standard of reference. The sensitivity, specificity and accuracy of each imaging technique in the diagnosis of each stage of CP were determined and compared by using the McNemar two-tailed analysis. Arthroscopy showed that 16 facets were normal. Four (30%) of 13 grade 1 lesions were detected with T1. Four lesions (30%) with T2 and three lesions (23%) with proton-weighted images were detected. Seven (53%) of 13 grade 1 lesions were detected with MRA. Grade 2 abnormalities were diagnosed in two (33%) of six facets with proton density-weighted pulse sequences, two (33%) of six facets with T1-weighted pulse sequences, in three (50%) of six facets with T2-weighted pulse sequences, in five (83%) of six facets with MRA sequences. Grade 3 abnormalities were diagnosed in three (71%) of seven facets with proton density- and T1-weighted images, five (71%) of seven facets with T2-weighted pulse sequences, six (85%) of seven facets with MRA sequences. Grade 4 CP was detected with equal sensitivity with T1-, proton density- and T2-weighted pulse sequences, all showing seven (87%) of the eight lesions. MRA again showed these findings in all eight patients. All imaging techniques were insensitive to grade 1 lesions and highly sensitive to grade 4 lesion, so that no

  10. Suitability of open-field autorefractors as pupillometers and instrument design effects

    Directory of Open Access Journals (Sweden)

    Carles Otero

    2017-04-01

    Full Text Available AIM: To determine the agreement and repeatability of the pupil measurement obtained with VIP-200 (Neuroptics, PowerRef II (Plusoptix, WAM-5500 (Grand Seiko and study the effects of instrument design on pupillometry. METHODS: Forty patients were measured twice in low, mid and high mesopic. Repeatability was analyzed with the within-subject standard deviation (Sw and paired t-tests. Agreement was studied with Bland-Altman plots and repeated measures ANOVA. Instrument design analysis consisted on measuring pupil size with PowerRef II simulating monocular and binocular conditions as well as with proximity cues and without proximity cues. RESULTS: The mean difference (±standard deviation between test-retest for low, mid and high mesopic conditions were, respectively: -0.09 (±0.16, -0.05 (±0.18 and -0.08 (±0.23 mm for Neuroptics, -0.05 (±0.17, -0.12 (±0.23 and -0.17 (±0.34 mm for WAM-5500, -0.04 (±0.27, -0.13 (±0.37 and -0.11 (±0.28 mm for PowerRef II. Regarding agreement with Neuroptics, the mean difference for low, mid and high mesopic conditions were, respectively: -0.48 (±0.35, -0.83 (±0.52 and -0.38 (±0.56 mm for WAM-5500, -0.28 (±0.56, -0.70 (±0.55 and -0.61 (±0.54 mm for PowerRef II. The mean difference of binocular minus monocular pupil measurements was: -0.83 (±0.87 mm; and with proximity cues minus without proximity cues was: -0.30 (±0.77 mm. CONCLUSION: All the instruments show similar repeat-ability. In all illumination conditions, agreement of Neuroptics with WAM-5500 and PowerRef II is not good enough, which can be partially induced due to their open field design.

  11. Suitability of open-field autorefractors as pupillometers and instrument design effects.

    Science.gov (United States)

    Otero, Carles; Aldaba, Mikel; Ferrer, Oriol; Gascón, Andrea; Ondategui-Parra, Juan C; Pujol, Jaume

    2017-01-01

    To determine the agreement and repeatability of the pupil measurement obtained with VIP-200 (Neuroptics), PowerRef II (Plusoptix), WAM-5500 (Grand Seiko) and study the effects of instrument design on pupillometry. Forty patients were measured twice in low, mid and high mesopic. Repeatability was analyzed with the within-subject standard deviation (Sw) and paired t -tests. Agreement was studied with Bland-Altman plots and repeated measures ANOVA. Instrument design analysis consisted on measuring pupil size with PowerRef II simulating monocular and binocular conditions as well as with proximity cues and without proximity cues. The mean difference (±standard deviation) between test-retest for low, mid and high mesopic conditions were, respectively: -0.09 (±0.16), -0.05 (±0.18) and -0.08 (±0.23) mm for Neuroptics, -0.05 (±0.17), -0.12 (±0.23) and -0.17 (±0.34) mm for WAM-5500, -0.04 (±0.27), -0.13 (±0.37) and -0.11 (±0.28) mm for PowerRef II. Regarding agreement with Neuroptics, the mean difference for low, mid and high mesopic conditions were, respectively: -0.48 (±0.35), -0.83 (±0.52) and -0.38 (±0.56) mm for WAM-5500, -0.28 (±0.56), -0.70 (±0.55) and -0.61 (±0.54) mm for PowerRef II. The mean difference of binocular minus monocular pupil measurements was: -0.83 (±0.87) mm; and with proximity cues minus without proximity cues was: -0.30 (±0.77) mm. All the instruments show similar repeat-ability. In all illumination conditions, agreement of Neuroptics with WAM-5500 and PowerRef II is not good enough, which can be partially induced due to their open field design.

  12. Testing various modes of installation for permanent broadband stations in open field environment

    Science.gov (United States)

    Vergne, Jérôme; Charade, Olivier; Arnold, Benoît; Louis-Xavier, Thierry

    2014-05-01

    In the framework of the RESIF (Réseau Sismologique et géodésique Français) project, we plan to install more than one hundred new permanent broadband stations in metropolitan France within the next 6 years. Whenever possible, the sensors will be installed in natural or artificial underground cavities that provide a stable thermal environment. However such places do not exist everywhere and we expect that about half the future stations will have to be set up in open fields. For such sites, we are thus looking for a standard model of hosting infrastructure for the sensors that would be easily replicated and would provide good noise level performances at long periods. Since early 2013, we have been operating a prototype station at Clévilliers, a small location in the sedimentary Beauce plain, where we test three kinds of buried seismic vaults and a down-hole installation. The cylindrical seismic vaults are 3m deep and 1m wide and only differ by the type of coupling between the casing and the concrete slab where we installed insulated Trillium T120PA seismometers. The down-hole installation consists in a 3m deep well hosting a Trillium Posthole seismometer. For reference, another sensor has been installed in a ~50cm deep hole, similarly to the way we test every new potential site. Here we compare the noise level in each infrastructure at different frequencies. We observe quite similar performances for the vertical component recorded in the different wells. Conversely, the noise levels on the horizontal components at periods greater than 10s vary by more than 20dB depending on the installation condition. The best results are obtained in the completely decoupled vault and for the down-hole setting, both showing performances comparable to some of our permanent stations installed in tunnels. The amplitude of the horizontal noise also appears to be highly correlated to wind speed recorded on site, even at long periods. The variable response of each vault to such

  13. OpenSIGLE - Crossroads for Libraries, Research and Educational Institutions in the field of Grey Literature

    OpenAIRE

    Farace, Dominic J. (GreyNet); Frantzen, Jerry (GreyNet); Stock, Christiane (INIST-CNRS); Henrot, Nathalie (INIST-CNRS); Schöpfel, Joachim (University of Lille); GreyNet, Grey Literature Network Service

    2009-01-01

    This poster is based on a paper presented at the Tenth International Conference on Grey Literature (GL10) in which GreyNet's collections of conference preprints were made accessible via the OpenSIGLE Repository. OpenSIGLE offers a unique distribution channel for European grey literature with roots dating back a quarter century. The experience of INIST as service provider and GreyNet as data provider will be further discussed including recent developments. The poster closes...

  14. An Alternative Interpretation of the Relationship between the Inferred Open Solar Flux and the Interplanetary Magnetic Field

    Science.gov (United States)

    Riley, Pete

    2007-01-01

    Photospheric observations at the Wilcox Solar Observatory (WSO) represent an uninterrupted data set of 32 years and are therefore unique for modeling variations in the magnetic structure of the corona and inner heliosphere over three solar cycles. For many years, modelers have applied a latitudinal correction factor to these data, believing that it provided a better estimate of the line-of-sight magnetic field. Its application was defended by arguing that the computed open flux matched observations of the interplanetary magnetic field (IMF) significantly better than the original WSO correction factor. However, no physically based argument could be made for its use. In this Letter we explore the implications of using the constant correction factor on the value and variation of the computed open solar flux and its relationship to the measured IMF. We find that it does not match the measured IMF at 1 AU except at and surrounding solar minimum. However, we argue that interplanetary coronal mass ejections (ICMEs) may provide sufficient additional magnetic flux to the extent that a remarkably good match is found between the sum of the computed open flux and inferred ICME flux and the measured flux at 1 AU. If further substantiated, the implications of this interpretation may be significant, including a better understanding of the structure and strength of the coronal field and I N providing constraints for theories of field line transport in the corona, the modulation of galactic cosmic rays, and even possibly terrestrial climate effects.

  15. Effects of 1950 MHz radiofrequency electromagnetic fields on Aβ processing in human neuroblastoma and mouse hippocampal neuronal cells

    International Nuclear Information System (INIS)

    Park, Jeongyeon; Kwon, Jong Hwa; Kim, Nam; Song, Kiwon

    2018-01-01

    Alzheimer’s disease (AD) is a neurodegenerative disease leading to progressive loss of memory and other cognitive functions. One of the well-known pathological markers of AD is the accumulation of amyloid-beta protein (Aβ), and its plaques, in the brain. Recent studies using Tg-5XFAD mice as a model of AD have reported that exposure to radiofrequency electromagnetic fields (RF-EMF) from cellular phones reduced Aβ plaques in the brain and showed beneficial effects on AD. In this study, we examined whether exposure to 1950 MHz RF-EMF affects Aβ processing in neural cells. We exposed HT22 mouse hippocampal neuronal cells and SH-SY5Y human neuroblastoma cells to RF-EMF (SAR 6 W/kg) for 2 h per day for 3 days, and analyzed the mRNA and protein expression of the key genes related to Aβ processing. When exposed to RF-EMF, mRNA levels of APP, BACE1, ADAM10 and PSEN1 were decreased in HT22, but the mRNA level of APP was not changed in SH-SY5Y cells. The protein expression of APP and BACE1, as well as the secreted Aβ peptide, was not significantly different between RF-EMF–exposed 7w-PSML, HT22 and SH-SY5Y cells and the unexposed controls. These observations suggest that RF-EMF exposure may not have a significant physiological effect on Aβ processing of neural cells in the short term. However, considering that we only exposed HT22 and SH-SY5Y cells to RF-EMF for 2 h per day for 3 days, we cannot exclude the possibility that 1950 MHz RF-EMF induces physiological change in Aβ processing with long-term and continuous exposure.

  16. Effects of interleukin-1beta and lipopolysaccharide on behavior of mice in the elevated plus-maze and open field tests.

    Science.gov (United States)

    Swiergiel, Artur H; Dunn, Adrian J

    2007-04-01

    It has been postulated that infections, inflammatory processes and resulting cytokines may be causative factors in emotional disorders, including depression and anxiety. Support for this possibility has been sought in studies of animal behavior following administration of interleukin-1 (IL-1) and lipopolysaccharide (LPS). However, such treatments induce a variety of behavioral responses, collectively known as sickness behavior, some of which could affect the performance in tests used to assess anxiety and depression. Thus the effects of peripheral administration of IL-1beta and LPS on the behavior of mice were studied in the elevated plus-maze (EPM) and the open field (OF). Mouse IL-1beta (30, 100, 300, and 1000 ng) was injected intraperitoneally 30 or 60 min, and LPS (0.5, 1 and 5 microg) 120 min before the tests. IL-1beta and LPS induced dose-dependent decreases in open arm entries and the time spent on the open arms in the EPM, effects considered to reflect anxiety-like behavior. However, entries to all arms were also reduced in a dose-dependent manner, indicating a decrease in general activity. In the OF, IL-1beta and LPS decreased the number of line crossings in the center of the field, that can also be considered to reflect anxiety-like behavior. However, this effect was accompanied by a similar decrease in line crossings in the periphery, as well as in rears and climbs. Thus the doses of IL-1beta and LPS necessary to induce these effects also decreased locomotor activity in the EPM and OF. Therefore, the behavioral responses induced by IL-1beta and LPS in the EPM and the OF considered to reflect anxiety must be interpreted in the light of this reduction in overall activity. Thus the results do not provide unequivocal support for the suggestion that LPS or IL-1 mediate anxiety. Nevertheless, because infections, endotoxins, and the ensuing cytokines cause alterations in CNS norepinephrine and serotonin, they may contribute to emotionality, and perhaps to

  17. A model to generate beam profiles of the Varian Clinac 4 for three-dimensional dose calculation: open fields

    International Nuclear Information System (INIS)

    Lam, K.S.; Lam, W.C.

    1984-01-01

    For the Clinac 4, open field profiles measured in the principal plane have higher intensity ''horns'' than those in off-axis planes. The maximum deviation occurs at 1-cm depth, where in the worst case of large field sizes and off-axis distances the deviation can be as high as 16% in the region near the horns. A model is proposed to generate open field beam profiles in off-axis planes, based on measured profiles in the transverse principal plane and in the largest field size diagonal plane of the machine. Within the central 90% portion of the field, the maximum deviation of the generated profiles from the measured ones at the same off-axis distance varies from about 3% at 1-cm depth to about 2% at 13-cm depth and then increases to less than 5% at 25-cm depth, even for very large field sizes and off-axis distances. Very little additional computer time and data storage are required for this procedure. Using these profiles, the Milan and Bentley method can be extended to three-dimensional treatment planning with good accuracy

  18. Free and Open Source Software for Geospatial in the field of planetary science

    Science.gov (United States)

    Frigeri, A.

    2012-12-01

    Information technology applied to geospatial analyses has spread quickly in the last ten years. The availability of OpenData and data from collaborative mapping projects increased the interest on tools, procedures and methods to handle spatially-related information. Free Open Source Software projects devoted to geospatial data handling are gaining a good success as the use of interoperable formats and protocols allow the user to choose what pipeline of tools and libraries is needed to solve a particular task, adapting the software scene to his specific problem. In particular, the Free Open Source model of development mimics the scientific method very well, and researchers should be naturally encouraged to take part to the development process of these software projects, as this represent a very agile way to interact among several institutions. When it comes to planetary sciences, geospatial Free Open Source Software is gaining a key role in projects that commonly involve different subjects in an international scenario. Very popular software suites for processing scientific mission data (for example, ISIS) and for navigation/planning (SPICE) are being distributed along with the source code and the interaction between user and developer is often very strict, creating a continuum between these two figures. A very widely spread library for handling geospatial data (GDAL) has started to support planetary data from the Planetary Data System, and recent contributions enabled the support to other popular data formats used in planetary science, as the Vicar one. The use of Geographic Information System in planetary science is now diffused, and Free Open Source GIS, open GIS formats and network protocols allow to extend existing tools and methods developed to solve Earth based problems, also to the case of the study of solar system bodies. A day in the working life of a researcher using Free Open Source Software for geospatial will be presented, as well as benefits and

  19. Naloxone effects on behavior of inbred mice with different response to emotional stress in open field test.

    Science.gov (United States)

    Nadorova, A V; Kozlovskaja, M M; Seredenin, S B

    2009-10-01

    Effects of nonspecific opiate receptor antagonist naloxone in doses of 0.1, 0.5, 1.0, 5.0, 10.0 mg/kg on open field behavior and spontaneous motor activity were studied in male BALB/c and C57Bl/6 mice. Differently directed effects of naloxone on behavioral parameters of emotional-stress reaction in BALB/c and C57Bl/6 mice were observed. Naloxone increased motor activity in the open field test in BALB/c mice, but decreased it in C57Bl/6 mice. In the absence of stress, naloxone in the studied dose range did not affect spontaneous motor activity in C57Bl/6 mice, and significantly reduced activity in BALB/c mice in doses 0.5 and 1.0 mg/kg.

  20. Clinical effects of buprenorphine on open field behaviour and gait symmetry in healthy and lame weaned piglets.

    Science.gov (United States)

    Meijer, Ellen; van Nes, Arie; Back, Willem; van der Staay, Franz Josef

    2015-12-01

    Lameness in pigs decreases animal welfare and economic profit for the farmer. An important reason for impaired welfare in lame animals is pain due to lameness. No direct measurement of pain is possible in animals, and methods to indirectly detect and quantify the amount of pain an animal is experiencing are urgently needed. In this study, two methods to assess pain associated with lameness in pigs were evaluated to determine if they were sensitive enough to detect a lameness reduction as an effect of an experimental analgesic medication. Asymmetry associated with lameness was objectively quantified using pressure mat kinetic parameters: peak vertical force (PVF), load rate (LR), vertical impulse (VI) and peak vertical pressure (PVP). Locomotor activity was assessed in an open field test. A dose of 0.04 mg/kg buprenorphine, a strong analgesic, was used to treat 10 lame pigs, while eight other lame pigs, treated with physiological saline solution, served as controls. Buprenorphine decreased lameness-associated asymmetry for pressure mat LR (P = 0.002), VI (P = 0.003) and PVP (P = 0.001) and increased activity of the lame pigs in the open field (P = 0.023), while saline-treated animals did not show any changes in asymmetry and became less active in the open field (P open field test are both sensitive enough to detect the analgesic effects of buprenorphine when used to treat moderate to severe clinical pain in a relatively small group of affected pigs. The methods used in this study may also provide promising additional tools for future research into early pain recognition and lameness treatment in pigs. Copyright © 2015 Elsevier Ltd. All rights reserved.

  1. Monosodium glutamate-associated alterations in open field, anxiety-related and conditioned place preference behaviours in mice.

    Science.gov (United States)

    Onaolapo, Olakunle James; Aremu, Olaleye Samuel; Onaolapo, Adejoke Yetunde

    2017-07-01

    The present study investigated changes in behaviour associated with oral monosodium glutamate (a flavouring agent), using the open field, elevated plus maze and conditioned place preference (CPP) paradigms, respectively. Mice were assigned to two groups for CPP [monosodium glutamate (MSG)-naïve (n = 40) and MSG-pretreated (n = 40)] and two groups for open field (OF) and elevated plus maze (EPM) tests [n = 40 each], respectively. Animals in respective groups were then divided into four subgroups (n = 10) (vehicle or MSG (80, 160 and 320 mg/kg)). MSG-naïve mice were observed in the CPP box in three phases (pre-conditioning, conditioning and post-conditioning). Mice were conditioned to MSG or an equivalent volume of saline. The MSG pretreatment group received vehicle or respective doses of MSG daily for 21 days, prior to conditioning. Mice in the OF or EPM groups received vehicle or doses of MSG (orally) for 21 days, at 10 ml/kg. Open field or EPM behaviours were assessed on days 1 and 21. At the end of the experiments, mice in the OF groups were sacrificed and brain homogenates used to assay glutamate and glutamine. Results showed that administration of MSG was associated with a decrease in rearing, dose-related mixed horizontal locomotor, grooming and anxiety-related response and an increase in brain glutamate/glutamine levels. Following exposure to the CPP paradigm, MSG-naïve and MSG-pretreated mice both showed 'drug-paired' chamber preference. The study concluded that MSG (at the administered doses) was associated with changes in open field activities, anxiety-related behaviours and brain glutamate/glutamine levels; its ingestion also probably leads to a stimulation of the brain reward system.

  2. Caffeine and sleep-deprivation mediated changes in open-field behaviours, stress response and antioxidant status in mice

    OpenAIRE

    Onaolapo, J. Olakunle; Onaolapo, Y. Adejoke; Akanmu, A. Moses; Olayiwola, Gbola

    2016-01-01

    Objectives: Effects of daily caffeine consumption on open-field behaviours, serum corticosterone and brain antioxidant levels were investigated after six hours of total sleep-deprivation in prepubertal mice. We tested the hypothesis that daily caffeine consumption may significantly alter behaviour, stress and antioxidative response of prepubertal mice to an acute episode of total sleep-deprivation. Methods: Prepubertal Swiss mice of both sexes were assigned to two main groups of 120 each (...

  3. Noise disturbance in open-plan study environments: a field study on noise sources, student tasks and room acoustic parameters.

    Science.gov (United States)

    Braat-Eggen, P Ella; van Heijst, Anne; Hornikx, Maarten; Kohlrausch, Armin

    2017-09-01

    The aim of this study is to gain more insight in the assessment of noise in open-plan study environments and to reveal correlations between noise disturbance experienced by students and the noise sources they perceive, the tasks they perform and the acoustic parameters of the open-plan study environment they work in. Data were collected in five open-plan study environments at universities in the Netherlands. A questionnaire was used to investigate student tasks, perceived sound sources and their perceived disturbance, and sound measurements were performed to determine the room acoustic parameters. This study shows that 38% of the surveyed students are disturbed by background noise in an open-plan study environment. Students are mostly disturbed by speech when performing complex cognitive tasks like studying for an exam, reading and writing. Significant but weak correlations were found between the room acoustic parameters and noise disturbance of students. Practitioner Summary: A field study was conducted to gain more insight in the assessment of noise in open-plan study environments at universities in the Netherlands. More than one third of the students was disturbed by noise. An interaction effect was found for task type, source type and room acoustic parameters.

  4. Potential formation in a collisionless plasma produced in an open magnetic field in presence of volume negative ion source

    International Nuclear Information System (INIS)

    Phukan, Ananya; Goswami, K. S.; Bhuyan, P. J.

    2014-01-01

    The electric potential near a wall for a multi-species plasma with volume produced negative ions in presence of axially varying magnetic field is studied following an analytical-numerical approach. A constant negative ion source is assumed throughout the plasma volume, along with finite temperature positive ions and Boltzmann electrons. The particles are assumed to be guided by an open magnetic field that has its maximum at the centre, and field strength decreasing towards the walls. The one dimensional (1D) Poisson equation is derived using an analytical approach, and then solved numerically to study the potential profiles. Effect of (a) negative ion production rate, (b) magnetic field profile, and (c) negative ion temperature on the potential profile has been investigated. A potential peak appears near the wall when the negative ion temperature and density are sufficiently high. Also, the presence of negative ions further decreases the potential in the plasma region for a finite Debye Length (λ D )

  5. [Association between the canine monoamine oxidase B (MAOB) gene polymorphisms and behavior of puppies in open-field test].

    Science.gov (United States)

    Li, Xiao-Hui; Xu, Han-Kun; Mao, Da-Gan; Ma, Da-Jun; Chen, Peng; Yang, Li-Guo

    2006-11-01

    Excitability, activity and exploration behavior of puppies in a novel open-field were tested in a total of 204 two-month-old German shepherd dog, labrador retriever or English springer spaniel puppies. The polymorphisms of monoamine oxidase B gene (MAOB) were detected by PCR-RFLP. Statistics analysis indicated that genotype and allele frequencies of the polymorphisms were significantly different among three breeds (P open-field test. The results showed that MAOB gene polymorphisms had a significant effect on walking time, squares crossed, lying time, the times of standing up against walls(P times of posture change (P=0.064). Walking time and squares crossed were higher in TT genotype puppies than those in TC and CC puppies (P times of posture change and standing up against walls were also higher than those in CC (P time in CC genotype puppies were higher than that in TT (P walking time, lying time, squares crossed, the times of posture change, the times of standing up against walls in the three dog breeds that was highly statistically significant (P open-field test and TT genotype has favorable effects in these behavior traits.

  6. Early deprivation increases high-leaning behavior, a novel anxiety-like behavior, in the open field test in rats.

    Science.gov (United States)

    Kuniishi, Hiroshi; Ichisaka, Satoshi; Yamamoto, Miki; Ikubo, Natsuko; Matsuda, Sae; Futora, Eri; Harada, Riho; Ishihara, Kohei; Hata, Yoshio

    2017-10-01

    The open field test is one of the most popular ethological tests to assess anxiety-like behavior in rodents. In the present study, we examined the effect of early deprivation (ED), a model of early life stress, on anxiety-like behavior in rats. In ED animals, we failed to find significant changes in the time spent in the center or thigmotaxis area of the open field, the common indexes of anxiety-like behavior. However, we found a significant increase in high-leaning behavior in which animals lean against the wall standing on their hindlimbs while touching the wall with their forepaws at a high position. The high-leaning behavior was decreased by treatment with an anxiolytic, diazepam, and it was increased under intense illumination as observed in the center activity. In addition, we compared the high-leaning behavior and center activity under various illumination intensities and found that the high-leaning behavior is more sensitive to illumination intensity than the center activity in the particular illumination range. These results suggest that the high-leaning behavior is a novel anxiety-like behavior in the open field test that can complement the center activity to assess the anxiety state of rats. Copyright © 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.

  7. Effects of environmental enrichment on the activity of the amygdala in micrencephalic rats exposed to a novel open field.

    Science.gov (United States)

    Matsuda, Wakoto; Ehara, Ayuka; Nakadate, Kazuhiko; Yoshimoto, Kanji; Ueda, Shuichi

    2018-01-01

    Environmental enrichment (EE) mediates recovery from sensory, motor, and cognitive deficits and emotional abnormalities. In the present study, we examined the effects of EE on locomotor activity and neuronal activity in the amygdala in control and methylazoxymethanol acetate (MAM)-induced micrencephalic rats after challenge in a novel open field. Control rats housed in EE (CR) showed reduced locomotor activity compared to rats housed in a conventional cage (CC), whereas hyperactivity was seen in MAM rats housed in a conventional cage (MC) and in MAM rats housed in EE (MR). Novel open field exposure in both CC and MC resulted in a marked increase in Fos expression in the anterior and posterior parts of the basolateral amygdaloid nucleus, basomedial nucleus, and medial nucleus, whereas these increases in expression were not observed in CR. The effect of EE on Fos expression in the amygdala was different in MR exposed to a novel open field compared to CR. Furthermore, we observed a quite different pattern of Fos expression in the central nucleus of the amygdala between control and MAM rats. The present results suggest that neuronal activity in the amygdala that responds to anxiety is altered in MAM rats, especially when the rats are reared in EE. These alterations may cause behavioral differences between control and MAM rats. © 2017 Japanese Teratology Society.

  8. A target field design of open multi-purpose RF coil for musculoskeletal MR imaging at 3T.

    Science.gov (United States)

    Gao, Fei; Zhang, Rui; Zhou, Diange; Wang, Xiaoying; Huang, Kefu; Zhang, Jue

    2016-10-01

    Musculoskeletal MR imaging under multi-angle situations plays an increasingly important role in assessing joint and muscle tissues system. However, there are still limitations due to the closed structures of most conventional RF coils. In this study, a time-harmonic target-field method was employed to design open multi-purpose coil (OMC) for multi-angle musculoskeletal MR imaging. The phantom imaging results suggested that the proposed OMC could achieve homogeneously distributed magnetic field and high signal-to-noise ratio (SNR) of 239.04±0.83 in the region of interest (ROI). The maximum temperature in the heating hazard test was 16°C lower than the standard regulation, which indicated the security of the designed OMC. Furthermore, to demonstrate the effectiveness of the proposed OMC for musculoskeletal MR imaging, especially for multi-angle imaging, a healthy volunteer was examined for MR imaging of elbow, ankle and knee using OMC. The in vivo imaging results showed that the proposed OMC is effective for MR imaging of musculoskeletal tissues at different body parts, with satisfied B1 field homogeneity and SNR. Moreover, the open structure of the OMC could provide a large joint movement region. The proposed open multi-purpose coil is feasible for musculoskeletal MR imaging, and potentially, it is more suitable for the evaluation of musculoskeletal tissues under multi-angle conditions. Copyright © 2016. Published by Elsevier Inc.

  9. Effects of environmental enrichment and paradoxical sleep deprivation on open-field behavior of amphetamine-treated mice.

    Science.gov (United States)

    Fukushiro, Daniela Fukue; Calzavara, Mariana Bendlin; Trombin, Thaís Fernanda; Lopez, Giorgia Batlle; Abílio, Vanessa Costhek; Andersen, Monica Levy; Tufik, Sergio; Frussa-Filho, Roberto

    2007-11-23

    Environmental enrichment or paradoxical sleep deprivation (PSD) has been shown to modify some responses elicited by drugs of abuse. The aims of the present study were to examine the effects of environmental enrichment and PSD, conducted separately or in association, on open-field behavior elicited by amphetamine (AMP) in mice. Male C57BL/6 mice were randomly assigned to live in either an enriched environmental condition (EC) or a standard environmental condition (SC) for 12 months since weaning. Some of the EC and SC mice were sleep deprived for 48 h, while others were maintained in their home-cages. Immediately after PSD or home-cage stay, the animals received an ip injection of saline, 2.5 mg/kg AMP or 5.0 mg/kg AMP. Fifteen minutes later, their open-field behavior was quantified. Whereas PSD enhanced total and peripheral locomotor activity of acutely AMP-treated mice, environmental enrichment presented only a trend toward enhancement. When PSD and environmental enrichment were combined, an increase in the total and peripheral locomotion frequencies of AMP-treated animals, similar to that observed after PSD, was revealed. In addition, PSD, environmental enrichment or their combination did not modify the effects of AMP on the other open-field behavioral parameters that were analyzed. The present findings demonstrate that some (but not all) of the behavioral effects caused by AMP acute administration can be similarly and specifically enhanced by both environmental enrichment and PSD in C57BL/6 mice.

  10. Effects of prenatal ethanol exposure and early experience on home-cage and open-field activity in mice.

    Science.gov (United States)

    Mothes, H K; Opitz, B; Werner, R; Clausing, P

    1996-01-01

    -C57BL/6 mice were intubated from gestational day 14-18 twice daily with 1.58 g/kg ethanol, 4.2 g/kg sucrose, or remained untreated. Offspring of ethanol treated or lab chow control groups were raised either by group-housed dams and weaned on postnatal day (PND) 28 or by individually housed dams and weaned on PND 21. Offspring of the sucrose control group were raised by individually housed dams and weaned on PND 21. Groups did not differ in pup weight or litter size. Offspring were assessed for home-cage activity (PND 36-38) and open-field behavior (PND 40-42). Mice prenatally exposed to ethanol showed increased activity in their home cages, whereas open-field behavior was generally not different from that of control groups. Conversely, different preweaning rearing conditions had affected open-field behavior, but not home-cage activity. In conclusion, home-cage behavior was a sensitive paradigm for detecting hyperactivity subsequent to a relatively low dose of prenatal ethanol in mice, and communal nesting/late weaning vs. individual nesting/ standard weaning may be a useful preweaning environmental manipulation to study possible modifications of prenatal neurobehavioral effects.

  11. Satisfying light conditions: a field study on perception of consensus light in Dutch open office environments

    NARCIS (Netherlands)

    Chraibi, S.; Lashina, T.A.; Shrubsole, P.; Aries, M.B.C.; van Loenen, E.J.; Rosemann, A.L.P.

    2016-01-01

    Workplace innovation has been changing the European office landscape into mostly open spaces, where enhanced interaction between people is combined by efficient use of space. However, challenges are found in offering individual preferred conditions in these multi-user spaces, especially when dealing

  12. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 740

    National Research Council Canada - National Science Library

    Overbay, Jr., Larry; Fling, Rick; McClug, Christina; Watts, Kimberly; Banta, Matthew

    2006-01-01

    The objective in the Standardized UXO Technology Demonstration Site Program is to evaluate the detection and discrimination capabilities of a given technology under various field and soil conditions...

  13. IMPAIRED LEARNING AND ABNORMAL OPEN-FIELD BEHAVIORS OF RATS AFTER EARLY POSTNATAL ANOXIA AND THE BENEFICIAL EFFECT OF THE CALCIUM-ANTAGONIST NIMODIPINE

    NARCIS (Netherlands)

    NYAKAS, C; MARKEL, E; SCHUURMAN, T; LUITEN, PGM

    1991-01-01

    Perinatal anoxia/hypoxia is considered a serious risk factor for normal brain development. Anoxia induced by repeated asphyxia at 2 and 4 days after birth resulted in a transient hyperactivity in the small open-field, and a behavioural depression in adult open-field activity of male Wistar rats. The

  14. Progressive Decrease of Peripapillary Angioflow Vessel Density During Structural and Visual Field Progression in Early Primary Open-angle Glaucoma.

    Science.gov (United States)

    Holló, Gábor

    2017-07-01

    To present a case of early primary open-angle glaucoma in which retinal nerve fiber layer thickness (RNFLT), ganglion cell complex (GCC), and visual field progression were accompanied with significant progression of peripapillary angioflow vessel density (PAFD) measured with optical coherence tomographic angiography. A 68-year-old female patient who was under topical intraocular pressure (IOP) lowering medication for 20 years for ocular hypertension of the right and preperimetric primary open-angle glaucoma of the left eye (with reproducible inferotemporal and superotemporal neuroretinal rim and RNFL loss) was prospectively imaged with the AngioVue OCT for RNFLT, GCC thickness, and PAFD, and investigated with the Octopus Normal G2 visual field test on the same days at 6-month intervals for 18 months, while the IOP of the left eye escaped from control. IOP of the left eye fluctuated between 14 and 30 mm Hg in the study period. RNFLT, GCC thickness, and peripapillary PAFD all decreased significantly (linear regression analysis, P=0.030, 0.040, and 0.020, respectively), and a significant 2.1 dB/y progression was seen for a superior visual field cluster. The RNFLT, peripapillary PAFD, and visual field of the right eye remained normal and unchanged. In our case IOP elevation, glaucomatous visual field conversion, and structural progression were accompanied with significant progressive decrease of peripapillary PAFD. The simultaneous thinning of RNFLT and GCC and decrease of peripapillary PAFD suggest that PAFD may potentially be an additional indicator of early progression in primary open-angle glaucoma.

  15. The Use of an Open Field Model to Assess Sound-Induced Fear and Anxiety Associated Behaviors in Labrador Retrievers.

    Science.gov (United States)

    Gruen, Margaret E; Case, Beth C; Foster, Melanie L; Lazarowski, Lucia; Fish, Richard E; Landsberg, Gary; DePuy, Venita; Dorman, David C; Sherman, Barbara L

    2015-01-01

    Previous studies have shown that the playing of thunderstorm recordings during an open-field task elicits fearful or anxious responses in adult beagles. The goal of our study was to apply this open field test to assess sound-induced behaviors in Labrador retrievers drawn from a pool of candidate improvised explosive devices (IED)-detection dogs. Being robust to fear-inducing sounds and recovering quickly is a critical requirement of these military working dogs. This study presented male and female dogs, with 3 minutes of either ambient noise (Days 1, 3 and 5), recorded thunderstorm (Day 2), or gunfire (Day 4) sounds in an open field arena. Behavioral and physiological responses were assessed and compared to control (ambient noise) periods. An observer blinded to sound treatment analyzed video records of the 9-minute daily test sessions. Additional assessments included measurement of distance traveled (activity), heart rate, body temperature, and salivary cortisol concentrations. Overall, there was a decline in distance traveled and heart rate within each day and over the five-day test period, suggesting that dogs habituated to the open field arena. Behavioral postures and expressions were assessed using a standardized rubric to score behaviors linked to canine fear and anxiety. These fear/anxiety scores were used to evaluate changes in behaviors following exposure to a sound stressor. Compared to control periods, there was an overall increase in fear/anxiety scores during thunderstorm and gunfire sound stimuli treatment periods. Fear/anxiety scores were correlated with distance traveled, and heart rate. Fear/anxiety scores in response to thunderstorm and gunfire were correlated. Dogs showed higher fear/anxiety scores during periods after the sound stimuli compared to control periods. In general, candidate IED-detection Labrador retrievers responded to sound stimuli and recovered quickly, although dogs stratified in their response to sound stimuli. Some dogs were

  16. Software Productivity of Field Experiments Using the Mobile Agents Open Architecture with Workflow Interoperability

    Science.gov (United States)

    Clancey, William J.; Lowry, Michael R.; Nado, Robert Allen; Sierhuis, Maarten

    2011-01-01

    We analyzed a series of ten systematically developed surface exploration systems that integrated a variety of hardware and software components. Design, development, and testing data suggest that incremental buildup of an exploration system for long-duration capabilities is facilitated by an open architecture with appropriate-level APIs, specifically designed to facilitate integration of new components. This improves software productivity by reducing changes required for reconfiguring an existing system.

  17. Chronic Toxoplasma gondii in Nurr1-Null Heterozygous Mice Exacerbates Elevated Open Field Activity

    OpenAIRE

    Eells, Jeffrey B.; Varela-Stokes, Andrea; Guo-Ross, Shirley X.; Kummari, Evangel; Smith, Holly M.; Cox, Erin; Lindsay, David S.

    2015-01-01

    Latent infection with Toxoplasma gondii is common in humans (approximately 30% of the global population) and is a significant risk factor for schizophrenia. Since prevalence of T. gondii infection is far greater than prevalence of schizophrenia (0.5-1%), genetic risk factors are likely also necessary to contribute to schizophrenia. To test this concept in an animal model, Nurr1-null heterozygous (+/-) mice and wild-type (+/+) mice were evaluate using an emergence test, activity in an open fie...

  18. Assessing the spatial distribution of Tuta absoluta (Lepidoptera: Gelechiidae) eggs in open-field tomato cultivation through geostatistical analysis.

    Science.gov (United States)

    Martins, Júlio C; Picanço, Marcelo C; Silva, Ricardo S; Gonring, Alfredo Hr; Galdino, Tarcísio Vs; Guedes, Raul Nc

    2018-01-01

    The spatial distribution of insects is due to the interaction between individuals and the environment. Knowledge about the within-field pattern of spatial distribution of a pest is critical to planning control tactics, developing efficient sampling plans, and predicting pest damage. The leaf miner Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) is the main pest of tomato crops in several regions of the world. Despite the importance of this pest, the pattern of spatial distribution of T. absoluta on open-field tomato cultivation remains unknown. Therefore, this study aimed to characterize the spatial distribution of T. absoluta in 22 commercial open-field tomato cultivations with plants at the three phenological development stages by using geostatistical analysis. Geostatistical analysis revealed that there was strong evidence for spatially dependent (aggregated) T. absoluta eggs in 19 of the 22 sample tomato cultivations. The maps that were obtained demonstrated the aggregated structure of egg densities at the edges of the crops. Further, T. absoluta was found to accomplish egg dispersal along the rows more frequently than it does between rows. Our results indicate that the greatest egg densities of T. absoluta occur at the edges of tomato crops. These results are discussed in relation to the behavior of T. absoluta distribution within fields and in terms of their implications for improved sampling guidelines and precision targeting control methods that are essential for effective pest monitoring and management. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  19. Magnitude of cyantraniliprole residues in tomato following open field application: pre-harvest interval determination and risk assessment.

    Science.gov (United States)

    Malhat, Farag; Kasiotis, Konstantinos M; Shalaby, Shehata

    2018-02-05

    Cyantraniliprole is an anthranilic diamide insecticide, belonging to the ryanoid class, with a broad range of applications against several pests. In the presented work, a reliable analytical technique employing high-performance liquid chromatography coupled with photodiode array detector (HPLC-DAD) for analyzing cyantraniliprole residues in tomato was developed. The method was then applied to field-incurred tomato samples collected after applications under open field conditions. The latter aimed to ensure the safe application of cyantraniliprole to tomato and contribute the derived residue data to the risk assessment under field conditions. Sample preparation involved a single step extraction with acetonitrile and sodium chloride for partitioning. The extract was purified utilizing florisil as cleanup reagent. The developed method was further evaluated by comparing the analytical results with those obtained using the QuEChERS technique. The novel method outbalanced QuEChERS regarding matrix interferences in the analysis, while it met all guideline criteria. Hence, it showed excellent linearity over the assayed concentration and yielded satisfactory recovery rate in the range of 88.9 to 96.5%. The half-life of degradation of cyantraniliprole was determined at 2.6 days. Based on the Codex MRL, the pre-harvest interval (PHI) for cyantraniliprole on tomato was 3 days, after treatment at the recommended dose. To our knowledge, the present work provides the first record on PHI determination of cyantraniliprole in tomato under open field conditions in Egypt and the broad Mediterranean region.

  20. Monitoring of In-Field Variability for Site Specific Crop Management Through Open Geospatial Information

    Science.gov (United States)

    Řezník, T.; Lukas, V.; Charvát, K.; Charvát, K., Jr.; Horáková, Š.; Křivánek, Z.; Herman, L.

    2016-06-01

    The agricultural sector is in a unique position due to its strategic importance around the world. It is crucial for both citizens (consumers) and the economy (both regional and global), which, ideally, should ensure that the whole sector is a network of interacting organisations. It is important to develop new tools, management methods, and applications to improve the management and logistic operations of agricultural producers (farms) and agricultural service providers. From a geospatial perspective, this involves identifying cost optimization pathways, reducing transport, reducing environmental loads, and improving the energy balance, while maintaining production levels, etc. This paper describes the benefits of, and open issues arising from, the development of the Open Farm Management Information System. Emphasis is placed on descriptions of available remote sensing and other geospatial data, and their harmonization, processing, and presentation to users. At the same time, the FOODIE platform also offers a novel approach of yield potential estimations. Validation for one farm demonstrated 70% successful rate when comparing yield results at a farm counting 1'284 hectares on one hand and results of a theoretical model of yield potential on the other hand. The presented Open Farm Management Information System has already been successfully registered under Phase 8 of the Global Earth Observation System of Systems (GEOSS) Architecture Implementation Pilot in order to support the wide variety of demands that are primarily aimed at agriculture and water pollution monitoring by means of remote sensing.

  1. Effects of a nonuniform open magnetic field on the plasma presheath

    International Nuclear Information System (INIS)

    Sato, Kunihiro; Miyawaki, Fujio

    1991-01-01

    Effects of a nonuniform magnetic field on the plasma presheath is numerically investigated using the plasma equation for a collisionless plasma with a finite-temperature particle source. The present calculation confirms that analytical solutions previously published by the authors are available over a wide range of mirror ratio. Potential drop in the presheath, which considerably depends on both the magnetic strength profile and the spatial distribution of the particle source, is remarkably increased by applying an expanding magnetic field when plasma particles are generated in the inner part of the plasma. An effect of a nonuniform magnetic field on sheath formation is also discussed by using the calculated ion distribution function. If the plasma equation has no singularity at the sheath edge, its solution satisfies the generalized Bohm criterion with the inequality sign in the expanding magnetic field. (author)

  2. Use of a standard set of profiles of open fields for photon beams in hand-held calculator (tele)

    International Nuclear Information System (INIS)

    Perez Guevara, Adrian; Rodriguez Zayas, Michael; Reyes Gonzalez, Tommy; Gonzalez Perez, Yelina; Sola Rodriguez, Yeline; Sanchez Zamora, Luis; Caballero, Roberto

    2009-01-01

    Clinical Dosimetry has gone through different stages in their evolution to our days advanced computer programs for treatment planning show the 3D dose distribution, complex algorithms for calculating 3D dose, complex treatment techniques, etc. All this has made the verification field treatment time or dose given to the PTV using calculations manuals are increasingly uncertain, reaching values that can exceed ±10%. It is proposed a calculation tool that uses EXCEL parameters obtained by fitting model profiles open fields. This calculator (TELE) taking information from the fields of PTV and treatments patient anatomical data allows verification of the dose contributions any point, correction of surface heterogeneity of the tissues present in the beam to the point of calculation. (Author)

  3. Extremely low frequency electromagnetic field in combination with β ...

    African Journals Online (AJOL)

    Fatemeh Sanie-Jahromi

    Extremely low frequency (<300 Hz) electromagnetic field (EMF) is shown to decrease ... Production and hosting by Elsevier B.V. This is an open access article under ..... mouse liver induced by morphine and protected by antioxidants.

  4. Band gap opening of bilayer graphene by F4-TCNQ molecular doping and externally applied electric field.

    Science.gov (United States)

    Tian, Xiaoqing; Xu, Jianbin; Wang, Xiaomu

    2010-09-09

    The band gap opening of bilayer graphene with one side surface adsorption of F4-TCNQ is reported. F4-TCNQ doped bilayer graphene shows p-type semiconductor characteristics. With a F4-TCNQ concentration of 1.3 x 10(-10) mol/cm(2), the charge transfer between each F4-TCNQ molecule and graphene is 0.45e, and the built-in electric field, E(bi), between the graphene layers could reach 0.070 V/A. The charge transfer and band gap opening of the F4-TCNQ-doped graphene can be further modulated by an externally applied electric field (E(ext)). At 0.077 V/A, the gap opening at the Dirac point (K), DeltaE(K) = 306 meV, and the band gap, E(g) = 253 meV, are around 71% and 49% larger than those of the pristine bilayer under the same E(ext).

  5. Heart Rate Variability in Nonlinear Rats with Different Orientation and Exploratory Activity in the Open Field.

    Science.gov (United States)

    Kur'yanova, E V; Teplyi, D L; Zhukova, Yu D; Zhukovina, N V

    2015-12-01

    The basic behavioral activity of nonlinear rats was evaluated from the sum of crossed peripheral and central squares and peripheral and central rearing postures in the open fi eld test. This index was low (30 episodes). Male rats with high score of orientation and exploratory activity were characterized by higher indexes of total heart rate variability than rats with low or intermediate activity. Specimens with a greater contribution of VLF waves into the total power spectrum of heart rate variability were shown to dominate among the rats with high behavioral activity. Our results are consistent with the notions of a suprasegmental nature of VLF waves.

  6. [Transient elevation of intraocular pressure in primary open-angle glaucoma patients after automated visual field examination in the winter].

    Science.gov (United States)

    Nishino, Kazuaki; Yoshida, Fujiko; Nitta, Akari; Saito, Mieko; Saito, Kazuuchi

    2013-12-01

    To evaluate retrospectively seasonal fluctuations of transient intraocular pressure (IOP) elevation after automated visual field examination in patients with primary open-angle glaucoma (POAG). We reviewed 53 consecutive patients with POAG who visited Kaimeido Ophthalmic and Dental Clinic from January 2011 to March 2013, 21 men and 32 women aged 67.7 +/- 11.2 years. The patients were divided into 4 groups, spring, summer, autumn, and winter according to the month of automated visual field examination and both eyes of each patient were enrolled. IOP was measured immediately after automated visual field examination (vf IOP) and compared with the average IOP from the previous 3 months (pre IOP) and with the average IOP from the following 3 months (post IOP) in each season. IOP elevation rate was defined as (vf IOP- pre IOP)/pre IOP x 100% and calculated for each season (paired t test). Additionally, the correlation between mean deviation (MD) and IOP elevation rate was evaluated (single regression analysis). Exclusion criteria were patients who received cataract surgery during this study or had a history of any previous glaucoma surgery. The automated visual field test was performed with a Humphrey field analyzer and the Central 30-2 FASTPAC threshold program. The average vf IOP was 14.5 +/- 2.5 mmHg, higher than pre IOP 13.8 +/- 2.4 mmHg (p field examination, especially in the winter but not in the summer.

  7. Euler-Lagrangian Model of Particle Motion and Deposition Effects in Electro-Static Fields based on OpenFoam

    Directory of Open Access Journals (Sweden)

    G Boiger

    2016-06-01

    Full Text Available In order to study the powder coating process of metal substrates, a comprehensive, numerical 3D Eulerian-LaGrangian model, featuring two particle sub-models, has been developed. The model considers the effects of electro-static, fluid-dynamic and gravity forces. The code has been implemented in C++ within the open source CFD platform OpenFoam®, is transient in nature with respect to the applied LaGrangian particle implementation and the electro-static field calculation and is stationary regarding fluid-dynamic phenomena. Qualitative validation of the developed solver has already been achieved by comparison to simple coating experiments and will hereby be presented alongside a thorough description of the model itself. Upon combining knowledge of the relevant dimensionless groups and the numerical model, a dimensionless chart, representing all possible states of coating, was populated with comprehensive, exemplary cases, which are shown here as well.

  8. Association of Bruch's membrane opening and optic disc morphology to axial length and visual field defects in eyes with primary open-angle glaucoma.

    Science.gov (United States)

    Nakanishi, Hideo; Suda, Kenji; Yoshikawa, Munemitsu; Akagi, Tadamichi; Kameda, Takanori; Ikeda, Hanako Ohashi; Yokota, Satoshi; Kurimoto, Yasuo; Tsujikawa, Akitaka

    2018-03-01

    To examine the morphology of Bruch's membrane opening (BMO), optic disc, and peripapillary atrophy (PPA) by scanning laser ophthalmoscopy (SLO) and spectral-domain optical coherence tomography (SD-OCT), and to determine their association with the axial length and visual field defects. This was a cross-sectional study of 94 eyes of 56 subjects; 77 eyes were diagnosed with primary open-angle glaucoma and 17 eyes as normal. The margins of the optic disc were determined in the SLO images, and that of the BMO in the SD-OCT images. The ovality and area of the BMO and the optic disc were measured. The beta and gamma-PPA areas were also measured. The association of each parameter with the axial length and the mean deviation (MD) of the visual field tests was determined by generalized estimating equations (GEEs). The optic disc ovality was associated with the axial length and the MD (β = -0.47, P = 7.6 × 10 -4 and β = 0.12, P = 0.040). The BMO ovality was not significantly associated with the axial length and the MD. The BMO area was associated with the axial length (β = 0.30, P = 0.029). A larger BMO area was associated with a thinner BMO-based neuroretinal rim width (BMO-MRW) after adjustments for the MD (β = -0.30, P = 2.1 × 10 -4 ). The beta- and gamma-PPA areas were associated with the axial length (β = 0.50, P = 7.4 × 10 -5 and β = 0.62, P = 4.2 × 10 -6 ). The optic disc ovality was associated with both the axial length and MD, whereas BMO ovality was not. Attention should be paid to the influence of the axial length-related enlargement of the BMO.

  9. Effect of flow field on open channel flow properties using numerical investigation and experimental comparison

    Energy Technology Data Exchange (ETDEWEB)

    Khazaee, I. [Department of Mechanical Engineering, Torbat-e-jam branch, Islamic Azad University, Torbat-e-jam (Iran, Islamic Republic of); Mohammadiun, M. [Department of Mechanical Engineering, Shahrood branch, Islamic Azad University, Shahrood (Iran, Islamic Republic of)

    2012-07-01

    In this paper a complete three-dimensional and two phase CFD model for flow distribution in an open channel investigated. The finite volume method (FVM) with a dynamic Sub grid-scale was carried out for seven cases of different aspect ratios, different inclination angles or slopes and convergence-divergence condition. The volume of fluid (VOF) method was used to allow the free-surface to deform freely with the underlying turbulence. The discharge through open channel flow is often evaluated by velocity-area integration method from the measurement of velocity at discrete locations in the measuring section. The variation of velocity along horizontal and vertical directions is thus very important to decide the location of the sensors. The aspect ratio of the channel, slope of the channel and divergence- convergence of the channel have investigated and the results show that the depth of water at the end of the channel is higher at AR=0.8 against the AR=0.4 and AR=1.2. Also it is clear that by increasing the inclination angle or slope of the channel in case1, case4 and case5 the depth of the water increases. Also it is clear that the outlet mass flow rate is at a minimum value at a range of inclination angle of the channel.

  10. Orthopedic and interventional applications at low field MRI with horizontally open configuration

    International Nuclear Information System (INIS)

    Koskinen, S.K.; Parkkola, R.K.; Karhu, J.; Komu, M.E.S.; Kormano, M.J.

    1997-01-01

    The recently introduced horizontally open configuration imagers allow imaging of knee, hip or shoulder during whole range of motion, which is not possible in conventional MR imagers. Special joint motion devices can be used to provide accurate and reproducible studies. In cervical spine, functional MR imaging may be useful in evaluating alarligament stability in patients with late sequelae of a whiplash injury, and in patients with rheumatoid arthritis who are clinically suspected of having a cervical myelopathy or superior migration of the odontoid process. In shoulder, full range of motion abduction study may be helpful in assessing the supraspinatus tendon impingement. To evaluate patellofemoral malalignment, quadriceps loading is recommended since associated contracting muscles and related soft tissue structures can be evaluated. The position of the femoral head relative to the acetabulum during different positions can be assessed. Open-configuration scanners provide an access to patients during scanning procedure, and therefore permit interventional procedures to be monitored with MRI. Such interventions include aspiration cytology/biopsy and different drainage procedures. (orig.) [de

  11. The spectral analysis of motion: An "open field" activity test example

    Directory of Open Access Journals (Sweden)

    Obradović Z.

    2013-01-01

    Full Text Available In this work we have described the new mathematical approach, with spectral analysis of the data to evaluate position and motion in the „„open field““ experiments. The aim of this work is to introduce several new parameters mathematically derived from experimental data by means of spectral analysis, and to quantitatively estimate the quality of the motion. Two original software packages (TRACKER and POSTPROC were used for transforming a video data to a log file, suitable for further computational analysis, and to perform analysis from the log file. As an example, results obtained from the experiments with Wistar rats in the „open field“ test are included. The test group of animals was treated with diazepam. Our results demonstrate that all the calculated parameters, such as movement variability, acceleration and deceleration, were significantly lower in the test group compared to the control group. We believe that the application of parameters obtained by spectral analysis could be of great significance in assessing the locomotion impairment in any kind of motion. [Projekat Ministarstva nauke Republike Srbije, br. III41007 i br. ON174028

  12. Brain histamine depletion enhances the behavioural sequences complexity of mice tested in the open-field: Partial reversal effect of the dopamine D2/D3 antagonist sulpiride.

    Science.gov (United States)

    Santangelo, Andrea; Provensi, Gustavo; Costa, Alessia; Blandina, Patrizio; Ricca, Valdo; Crescimanno, Giuseppe; Casarrubea, Maurizio; Passani, M Beatrice

    2017-02-01

    Markers of histaminergic dysregulation were found in several neuropsychiatric disorders characterized by repetitive behaviours, thoughts and stereotypies. We analysed the effect of acute histamine depletion by means of i. c.v. injections of alpha-fluoromethylhistidine, a blocker of histidine decarboxylase, on the temporal organization of motor sequences of CD1 mice behaviour in the open-field test. An ethogram encompassing 9 behavioural components was employed. Durations and frequencies were only slightly affected by treatments. However, as revealed by multivariate t-pattern analysis, histamine depletion was associated with a striking increase in the number of behavioural patterns. We found 42 patterns of different composition occurring, on average, 520.90 ± 50.23 times per mouse in the histamine depleted (HD) group, whereas controls showed 12 different patterns occurring on average 223.30 ± 20.64 times. Exploratory and grooming behaviours clustered separately, and the increased pattern complexity involved exclusively exploratory patterns. To test the hypothesis of a histamine-dopamine interplay on behavioural pattern phenotype, non-sedative doses of the D2/D3 antagonist sulpiride (12.5-25-50 mg/kg) were additionally administered to different groups of HD mice. Sulpiride counterbalanced the enhancement of exploratory patterns of different composition, but it did not affect the mean number of patterns at none of the doses used. Our results provide new insights on the role of histamine on repetitive behavioural sequences of freely moving mice. Histamine deficiency is correlated with a general enhancement of pattern complexity. This study supports a putative involvement of histamine in the pathophysiology of tics and related disorders. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. ENU mutagenesis screening for dominant behavioral mutations based on normal control data obtained in home-cage activity, open-field, and passive avoidance tests.

    Science.gov (United States)

    Wada, Yumiko; Furuse, Tamio; Yamada, Ikuko; Masuya, Hiroshi; Kushida, Tomoko; Shibukawa, Yoko; Nakai, Yuji; Kobayashi, Kimio; Kaneda, Hideki; Gondo, Yoichi; Noda, Tetsuo; Shiroishi, Toshihiko; Wakana, Shigeharu

    2010-01-01

    To establish the cutoff values for screening ENU-induced behavioral mutations, normal variations in mouse behavioral data were examined in home-cage activity (HA), open-field (OF), and passive-avoidance (PA) tests. We defined the normal range as one that included more than 95% of the normal control values. The cutoffs were defined to identify outliers yielding values that deviated from the normal by less than 5% for C57BL/6J, DBA/2J, DBF(1), and N(2) (DXDB) progenies. Cutoff values for G1-phenodeviant (DBF(1)) identification were defined based on values over +/- 3.0 SD from the mean of DBF(1) for all parameters assessed in the HA and OF tests. For the PA test, the cutoff values were defined based on whether the mice met the learning criterion during the 2nd (at a shock intensity of 0.3 mA) or the 3rd (at a shock intensity of 0.15 mA) retention test. For several parameters, the lower outliers were undetectable as the calculated cutoffs were negative values. Based on the cutoff criteria, we identified 275 behavioral phenodeviants among 2,646 G1 progeny. Of these, 64 were crossed with wild-type DBA/2J individuals, and the phenotype transmission was examined in the G2 progeny using the cutoffs defined for N(2) mice. In the G2 mice, we identified 15 novel dominant mutants exhibiting behavioral abnormalities, including hyperactivity in the HA or OF tests, hypoactivity in the OF test, and PA deficits. Genetic and detailed behavioral analysis of these ENU-induced mutants will provide novel insights into the molecular mechanisms underlying behavior.

  14. Use of a force-sensing automated open field apparatus in a longitudinal study of multiple behavioral deficits in CAG140 Huntington's disease model mice.

    Science.gov (United States)

    Fowler, Stephen C; Muma, Nancy A

    2015-11-01

    Behavioral testing of mouse models of Huntington's disease (HD) is a key component of preclinical assessment for potential pharmacological intervention. An open field with a force plate floor was used to quantify numerous spontaneous behaviors in a slowly progressing model of HD. CAG140 (+/+, +/-, -/-) male and female mice were compared in a longitudinal study from 6 to 65 weeks of age. Distance traveled, wall rears, wall rear duration, number of low mobility bouts, in-place movements, number of high velocity runs, and gait parameters (stride rate, stride length, and velocity) were extracted from the ground reaction forces recorded in 20-min actometer sessions. Beginning at 11 weeks, HD mice (both +/- and +/+) were consistently hypoactive throughout testing. Robust hypoactivity at 39 weeks of age was not accompanied by gait disturbances. By 52 and 65 weeks of age the duration of wall rears increased and in-place tremor-like movements emerged at 65 weeks of age in the +/+, but not in the +/- HD mice. Taken together, these results suggest that hypoactivity preceding frank motor dysfunction is a characteristic of CAG140 mice that may correspond to low motivation to move seen clinically in the premanifest/prediagnostic stage in human HD. The results also show that the force plate method provides a means for tracking the progression of behavioral dysfunction in HD mice beyond the stage when locomotion is lost while enabling quantification of tremor-like and similar in-place behaviors without a change in instrumentation. Use of force plate actometry also minimizes testing-induced enrichment effects when batteries of different tests are carried out longitudinally. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Determination of the effects of extremely low frequency electromagnetic fields on the percentages of peripheral blood leukocytes and histology of lymphoid organs of the mouse

    International Nuclear Information System (INIS)

    Cicekcibasi, Aynur E.; Salbacak, A.; Buyukmumcu, M.; Okudan, N.; Celik, I.; Ozkan, Y.

    2008-01-01

    Objective was to determine the effects of very weak, extremely low frequency (50Hz) electromagnetic field (ELF-EMF) on the relative spleen weight, lymphoid organ histology, peripheral blood leukocyte and alpha-naphthyl acetate esterase positive (ANAE-positive) lymphocyte percentages of mouse. The study was carried out in the Scientific Research and Application Center of Selcuk University, Konya, Turkey in 2005. A total of 120 Swiss albino mice were divided into 6 groups (20 in each group). The experimental animals were exposed to 1, 2, 3, 4 and 5 uT flux intensities (rms) of EMF at 50 Hz for 40 days. In the exposure groups with 20 animals, the body weight (BW) increased gradually in higher field intensities and reached at peak level in the 4 uT and then slightly decreased. The relative spleen weight (% of BW) was not affected. The ELF-EMF treatment did not cause any significant change in lymphocyte, monocyte and ANA-positive lymphocyte ratios, whereas percentages of neutropholis and basophiles changed non-linearly. Any change in the lymphoid organ histology which attributable to the field effect, was not observed in the exposure groups. Extremely frequency-EMF exposure with the flux intensities between 1-5 uT for 40 days did not cause any effect on the relative spleen weight, lymphoid organ histology, leukocyte and ANAE-positive lymphocyte percentages of the mouse. (author)

  16. Effects of buspirone, diazepam, and zolpidem on open field behavior, and brain [3H]muscimol binding after buspirone pretreatment.

    Science.gov (United States)

    Siemiatkowski, M; Sienkiewicz-Jarosz, H; Członkowska, A I; Bidziński, A; Płaźnik, A

    2000-07-01

    The effects of 5-HT(1A) receptor agonist buspirone, a nonselective (diazepam), and a selective (zolpidem) GABA(A) receptor agonist were compared in the open field test of neophobia. Unhabituated rats were pretreated with the drugs once, prior to a first exposure to the open field, and their behavior was recorded both during this test and during a second trial 24 h later. It has been hypothesized that the decrease in exploratory activity observed during the second test session may be considered an adaptive reaction to the first day aversive experience (neophobia). If so, a selective modulation of 5-HT and GABA systems activity during the test could bring about significant changes in animal behavior on the retest. Buspirone at the lowest dose of 0.3 mg/kg revealed anxiolytic-like properties on the first day, whereas the action of diazepam and zolpidem was modulated by the dose-related sedative effect. At the dose of 2.4 mg/kg buspirone elicited delayed in time anxiolytic-like action, i.e., produced the antithigmotactic effect during the retrial 24 h later. Diazepam and zolpidem failed to exhibit similar profile of action. Autoradiography of [3H]muscimol binding after pretreatment of rats with buspirone showed a significant increase in the selective radioligand binding within the frontal cortex and a similar, near-significant tendency in the dentate gyrus of the hippocampus. The behavioral data validate buspirone as important drug for the treatment of anxiety disorders, devoid of disruptive influence on motor and cognitive processes. The open field test, as modified by us, appeared sensitive in distinguishing the behavioral profiles of action of different anxiolytic compounds, including 5-HT(1A) receptor agonist. The present results support the assumption that reduced turnover of 5-HT due to stimulation of 5-HT(1A) autoreceptors, may bring about changes in GABA(A) receptor system activity, in some brain structures, leading to the anxiolytic effect.

  17. Hippocampus lipid peroxidation induced by residual oil fly ash intranasal instillation versus habituation to the open field.

    Science.gov (United States)

    Zanchi, Ana Claudia; Saiki, Mitiko; Saldiva, Paulo Hilário Nascimento; Barros, Helena Maria Tannhauser; Rhoden, Claudia Ramos

    2010-01-01

    Epidemiological studies have demonstrated the adverse effects of particulate matter (PM) inhalation on the respiratory and cardiovascular systems. It has been reported that air pollution may affect the central nervous system and decrease cognitive function. In rats, residual oil fly ash (ROFA) instillation causes decreased motor activity and increased lipid peroxidation in the striatum and the cerebellum. Our objective was to determine whether chronic instillation of particles induces changes in learning and memory in rats and whether oxidants in the hippocampus may contribute to these adverse effects. Forty-five-day-old male Wistar rats were exposed to ROFA by intranasal instillation and were treated with N-acetylcysteine (NAC) at 150 mg/kg i.p. for 30 days. Control groups were exposed to ROFA, NAC, or neither. On days 1, 8, and 30 of the protocol, rats were submitted to the open field test to evaluate habituation. After the last open field session, the rats were killed by decapitation. The hippocampus was used to determine lipid peroxidation (LP) by the thiobarbituric acid-reactive substances test. ROFA instillation induced an increase in LP in the hippocampus compared to all treatment groups (p = .012). NAC treatment blocked these changes. All of the treatment groups presented a decrease in the frequency of peripheral walking (p = .001), rearing (p = .001), and exploration (p = .001) over time. Our study demonstrates that exposure to particles for 30 days and/or NAC treatment do not modify habituation to an open field, a simple form of learning and memory in rats, and that oxidative damage induced by ROFA does not modulate these processes.

  18. Caffeine and sleep-deprivation mediated changes in open-field behaviours, stress response and antioxidant status in mice.

    Science.gov (United States)

    Onaolapo, J Olakunle; Onaolapo, Y Adejoke; Akanmu, A Moses; Olayiwola, Gbola

    2016-01-01

    Effects of daily caffeine consumption on open-field behaviours, serum corticosterone and brain antioxidant levels were investigated after six hours of total sleep-deprivation in prepubertal mice. We tested the hypothesis that daily caffeine consumption may significantly alter behaviour, stress and antioxidative response of prepubertal mice to an acute episode of total sleep-deprivation. Prepubertal Swiss mice of both sexes were assigned to two main groups of 120 each (subdivided into 6 groups of 10 each, based on sex), and administered vehicle or graded oral doses of caffeine (10, 20, 40, 80 and 120 mg/kg/day) for 14 days. On day 14, a main group was subjected to 6 h of total sleep-deprivation by 'gentle-handling'. Open-field behaviours were then assessed in both groups, after which animals were euthanized, and levels of corticosterone, superoxide dismutase and glutathione peroxidase assayed. Horizontal locomotion, rearing and grooming increased significantly, compared to control, with sleep-deprived (SD) mice showing stronger caffeine-driven responses at higher doses; and SD female mice showing sustained response to caffeine, compared to respective males. Plasma corticosterone increased with increasing doses of caffeine in both non sleep-deprived (NSD) and SD mice; although SD mice had higher corticosterone levels. Sleep-deprivation and/or higher doses of caffeine were associated with derangements in brain antioxidant levels. Repeated caffeine consumption and/or acute sleep-deprivation led to significant changes in pattern of open-field behaviour and stress/antioxidant response in mice. Responses seen in the study are probably due to modulatory effects of caffeine on the total body response to stressful stimuli.

  19. Oral 2-hydroxyoleic acid inhibits reflex hypersensitivity and open-field-induced anxiety after spared nerve injury.

    Science.gov (United States)

    Avila-Martin, G; Galan-Arriero, I; Ferrer-Donato, A; Busquets, X; Gomez-Soriano, J; Escribá, P V; Taylor, J

    2015-01-01

    Recently, fatty acids have been shown to modulate sensory function in animal models of neuropathic pain. In this study, the antinociceptive effect of 2-hydroxyoleic acid (2-OHOA) was assessed following spared nerve injury (SNI) with reflex and cerebrally mediated behavioural responses. Initial antinociceptive behavioural screening of daily administration of 2-OHOA (400 mg/kg, p.o.) was assessed in Wistar rats by measuring hindlimb reflex hypersensitivity to von Frey and thermal plate stimulation up to 7 days after SNI, while its modulatory effect on lumbar spinal dorsal horn microglia reactivity was assessed with OX-42 immunohistochemistry. In vitro the effect of 2-OHOA (120 μM) on cyclooxygenase protein expression (COX-2/COX-1 ratio) in lipopolysaccharide-activated macrophage cells was tested with Western blot analysis. Finally, the effects of 2-OHOA treatment on the place escape aversion paradigm (PEAP) and the open-field-induced anxiety test were tested at 21 days following nerve injury compared with vehicle-treated sham and pregabalin-SNI (30 mg/kg, p.o.) control groups. Oral 2-OHOA significantly reduced ipsilateral mechanical and thermal hypersensitivity up to 7 days after SNI. Additionally 2-OHOA decreased the COX-2/COX-1 ratio in lipopolysaccharide-activated macrophage cells and OX-42 expression within the ipsilateral lumbar spinal dorsal horn 7 days after SNI. 2-OHOA significantly restored inner-zone exploration in the open-field test compared with the vehicle-treated sham group at 21 days after SNI. Oral administration of the modified omega 9 fatty acid, 2-OHOA, mediates antinociception and prevents open-field-induced anxiety in the SNI model in Wistar rats, which is mediated by an inhibition of spinal dorsal horn microglia activation. © 2014 European Pain Federation - EFIC®

  20. A detailed analysis of open-field habituation and behavioral and neurochemical antidepressant-like effects in postweaning enriched rats.

    Science.gov (United States)

    Brenes, Juan C; Padilla, Michael; Fornaguera, Jaime

    2009-01-30

    Our previous work has shown that male Sprague-Dawley rats reared in social isolation, standard housing and environmental enrichment differ in their spontaneous open-field activity and in some neurobehavioral depressive-like parameters. Here, we extended this evidence by using a shorter postweaning rearing period (1 month) and including additional evaluations. First, in order to obtain a better characterization of the exploratory strategies among rearing conditions we analyzed in detail the spontaneous activity at the first minute and during the 10-min session. Second, we asked whether the changes in open-field activity were related with basal anxiety levels in the elevated plus-maze. Third, behavior in the forced-swimming test was analyzed and afterward, the tissue levels of hippocampal norepinephrine and serotonin were assessed. The possible relationship between neurotransmitters and forced-swimming behavior were explored through correlation analyses. We found that rearing conditions (i) differed on locomotor habituation and on sensory-motor exploration at the first minute and during the 10-min session without modifying the plus-maze behavior; (ii) affected differentially the grooming time, its sequential components, and the relationship between grooming and locomotor parameters; (iii) modified forced-swimming behavior and the hippocampal concentration of norepinephrine, serotonin, and its turnover; and (iv) produced different correlation patterns between both neurotransmitters and forced-swimming behaviors. Overall, environmental enrichment accelerated open-field habituation and led to behavioral and neurochemical antidepressant-like effects. In contract, isolation rearing strongly impaired habituation and simple information processing, but showed marginal effects on depressive-like behavior and on hippocampal neurochemistry. The current results suggest that differential rearing is not only a useful procedure to study behavioral plasticity or rigidity in response

  1. Connexin30-deficient mice show increased emotionality and decreased rearing activity in the open-field along with neurochemical changes.

    Science.gov (United States)

    Dere, E; De Souza-Silva, M A; Frisch, C; Teubner, B; Söhl, G; Willecke, K; Huston, J P

    2003-08-01

    Gap-junction channels in the brain, formed by connexin (Cx) proteins with a distinct regional/cell-type distribution, allow intercellular electrical and metabolic communication. In astrocytes, mainly the connexins 43, 26 and 30 are expressed. In addition, connexin30 is expressed in ependymal and leptomeningeal cells, as well as in skin and cochlea. The functional implications of the astrocytic gap-junctional network are not well understood and evidence regarding their behavioural relevance is lacking. Thus, we have tested groups of Cx30-/-, Cx30+/-, and Cx30+/+ mice in the open-field, an object exploration task, in the graded anxiety test and on the rotarod. The Cx30-/- mice showed reduced exploratory activity in terms of rearings but not locomotion in the open-field and object exploration task. Furthermore, Cx30-/- mice exhibited anxiogenic behaviour as shown by higher open-field centre avoidance and corner preference. Graded anxiety test and rotarod performance was similar across groups. The Cx30-/- mice had elevated choline levels in the ventral striatum, possibly related to their aberrant behavioural phenotypes. The Cx30+/- mice had lower dopamine and metabolite levels in the amygdala and ventral striatum and lower hippocampal 5-hydroxyindole acid (5-HIAA) concentrations relative to Cx30+/+ mice. Furthermore, the Cx30+/- mice had lower acetylcholine concentrations in the ventral striatum and higher choline levels in the neostriatum, relative to Cx30+/+ mice. Our data suggest that the elimination of connexin30 can alter the reactivity to novel environments, pointing to the importance of gap-junctional signalling in behavioural processes.

  2. Effects of acute and repeated oral exposure to the organophosphate insecticide chlorpyrifos on open-field activity in chicks.

    Science.gov (United States)

    Al-Badrany, Y M A; Mohammad, F K

    2007-11-01

    The effects of the organophosphate insecticide chlorpyrifos on 5min open-field activity were examined in a 7-15 days old chick model. Chlorpyrifos was acutely administered taking into account cholinesterase inhibition and determination of the acute (24h) median lethal dose (LD50). The oral LD50 value of chlorpyrifos in chicks was 18.14mg/kg, with cholinergic toxicosis observed on intoxicated chicks. Chlorpyrifos at the dose rates of 5,10 and 20mg/kg orally produced within 2h signs of cholinergic toxicosis in the chicks and significantly inhibited plasma (40-70%), whole brain (43-69%) and liver (31-46%) cholinesterase activities in a dose-dependent manner. Chlorpyrifos at 2 and 4mg/kg, orally did not produce overt signs of cholinergic toxicosis, but decreased (30, 60 and 90min after dosing) the general locomotor activity of the chicks as seen by a significant increase in the latency to move from the central square of the open-field arena, decreases in the numbers of lines crossed and vocalization score. Repeated daily chlorpyrifos treatments (2 and 4mg/kg, orally) for seven consecutive days also caused hypoactivity in chicks in the open-field behavioral paradigm. Only the high dose of chlorpyrifos (4mg/kg, orally) given repeatedly for 7 days caused significant cholinesterase inhibition in the whole brain (37%) and the liver (22%). In conclusion, chlorpyrifos at single or short-term repeated doses-induced behavioral changes in 7-15 days old chicks, in a model that could be used for further neurobehavioral studies involving subtle effects of organophosphates on chicks.

  3. Algebraic solutions in open string field theory – a lightning review

    Czech Academy of Sciences Publication Activity Database

    Schnabl, Martin

    2010-01-01

    Roč. 50, č. 3 (2010), s. 102-108 ISSN 1210-2709 Grant - others:EUROHORC(XE) EYI/07/E010 Institutional research plan: CEZ:AV0Z10100502 Keywords : string field theory * tachyon condensation Subject RIV: BF - Elementary Particles and High Energy Physics https://ojs.cvut.cz/ojs/index.php/ap/article/download/1213/1045

  4. Prediction of the Low Frequency Wave Field on Open Coastal Beaches

    National Research Council Canada - National Science Library

    Ozkan-Haller, H. T

    2005-01-01

    ... (both abrupt and gradual) affect the resulting low frequency wave climate. 3. The assessment of the importance of interactions between different modes of time-varying motions in the nearshore region, as well as interactions between these modes and the incident wave field. 4. To arrive at a predictive understanding of low frequency motions.

  5. Seedling Emergence and Phenotypic Response of Common Bean Germplasm to Different Temperatures under Controlled Conditions and in Open Field

    Directory of Open Access Journals (Sweden)

    Antonio M. DE RON

    2016-08-01

    Full Text Available Rapid and uniform seed germination and seedling emergence under diverse environmental conditions is a desirable characteristic for crops. Common bean genotypes (Phaseolus vulgaris L. differ in their low temperature tolerance regarding growth and yield. Cultivars tolerant to low temperature during the germination and emergence stages and carriers of the grain quality standards demanded by consumers are needed for the success of the bean crop. The objectives of this study were i to screen the seedling emergence and the phenotypic response of bean germplasm under a range of temperatures in controlled chamber and field conditions to display stress-tolerant genotypes with good agronomic performances and yield potential, and ii to compare the emergence of bean seedlings under controlled environment and in open field conditions to assess the efficiency of genebanks standard germination tests for predicting the performance of the seeds in the field. Three trials were conducted with 28 dry bean genotypes in open field and in growth chamber under low, moderate and warm temperature. Morpho-agronomic data were used to evaluate the phenotypic performance of the different genotypes. Cool temperatures resulted in a reduction of the rate of emergence in the bean genotypes, however, emergence and early growth of bean could be under different genetic control and these processes need further research to be suitably modeled. Nine groups arose from the Principal Component Analysis (PCA representing variation in emergence time and proportion of emergence in the controlled chamber and in the open field indicating a trend to lower emergence in large and extra-large seeded genotypes. Screening of seedling emergence and phenotypic response of the bean germplasm under a range of temperatures in controlled growth chambers and under field conditions showed several genotypes, as landraces 272, 501, 593 and the cultivar Borlotto, with stress-tolerance at emergence and high

  6. Seedling Emergence and Phenotypic Response of Common Bean Germplasm to Different Temperatures under Controlled Conditions and in Open Field.

    Science.gov (United States)

    De Ron, Antonio M; Rodiño, Ana P; Santalla, Marta; González, Ana M; Lema, María J; Martín, Isaura; Kigel, Jaime

    2016-01-01

    Rapid and uniform seed germination and seedling emergence under diverse environmental conditions is a desirable characteristic for crops. Common bean genotypes (Phaseolus vulgaris L.) differ in their low temperature tolerance regarding growth and yield. Cultivars tolerant to low temperature during the germination and emergence stages and carriers of the grain quality standards demanded by consumers are needed for the success of the bean crop. The objectives of this study were (i) to screen the seedling emergence and the phenotypic response of bean germplasm under a range of temperatures in controlled chamber and field conditions to display stress-tolerant genotypes with good agronomic performances and yield potential, and (ii) to compare the emergence of bean seedlings under controlled environment and in open field conditions to assess the efficiency of genebanks standard germination tests for predicting the performance of the seeds in the field. Three trials were conducted with 28 dry bean genotypes in open field and in growth chamber under low, moderate, and warm temperature. Morpho-agronomic data were used to evaluate the phenotypic performance of the different genotypes. Cool temperatures resulted in a reduction of the rate of emergence in the bean genotypes, however, emergence and early growth of bean could be under different genetic control and these processes need further research to be suitably modeled. Nine groups arose from the Principal Component Analysis (PCA) representing variation in emergence time and proportion of emergence in the controlled chamber and in the open field indicating a trend to lower emergence in large and extra-large seeded genotypes. Screening of seedling emergence and phenotypic response of the bean germplasm under a range of temperatures in controlled growth chambers and under field conditions showed several genotypes, as landraces 272, 501, 593, and the cultivar Borlotto, with stress-tolerance at emergence, and high yield

  7. Effects of chronic restraint stress and estradiol on open field activity, spatial memory, and monoaminergic neurotransmitters in ovariectomized rats.

    Science.gov (United States)

    Bowman, R E; Ferguson, D; Luine, V N

    2002-01-01

    Twenty-one days of chronic restraint stress impairs male rat performance on the radial arm maze [Luine et al. (1994) Brain Res. 639, 167-170], but enhances female rat performance [Bowman et al. (2001) Brain Res. 904, 279-289]. To assess possible ovarian hormone mechanisms underlying this sexually dimorphic response to stress, we examined chronic stress effects in ovariectomized rats. Ovariectomized rats received Silastic capsule implants containing cholesterol or estradiol and were assigned to a daily restraint stress (21 days, 6 h/day) or non-stress group. Following the stress period, subjects were tested for open field activity and radial arm maze performance. Stress and estradiol treatment affected open field activity. All stressed animals, with or without estradiol treatment, made fewer total outer sector crossings. In contrast, estradiol-treated animals, with or without stress, made more inner sector visits, an indication that estradiol decreased anxious behavior on the open field across time. As measured by the total number of visits required to complete the task, stress did not affect radial arm maze performance in ovariectomized rats, but estradiol-treated animals, with or without stress, performed better than non-treated animals on the radial arm maze. Stressed subjects receiving estradiol showed the best radial arm maze performance. Following killing, tissue samples were obtained from various brain regions known to contribute to learning and memory, and monoamine and metabolite levels were measured. Several changes were observed in response to both stress and estradiol. Most noteworthy, stress treatment decreased homovanillic acid levels in the prefrontal cortex, an effect not previously observed in stressed intact females. Estradiol treatment increased norepinephrine levels in CA3 region of the hippocampus, mitigating stress-dependent changes. Both stress and estradiol decreased dentate gyrus levels of 5-hydroxyindole acetic acid. In summary, the current

  8. Open and disconnected magnetic field lines within coronal mass ejections in the solar wind: Evidence for 3-dimensional reconnection

    Science.gov (United States)

    Gosling, J. T.; Birn, J.; McComas, D. J.; Phillips, J. L.; Hesse, M.

    1995-01-01

    Measurements of suprathermal electron fluxes in the solar wind at energies greater than approximatley 80 eV indicate that magnetic field lines within coronal mass ejections. CMEs, near and beyond 1 AU are normally connected to the Sun at both ends. However, a preliminary reexamination of events previously identified as CMEs in the ISEE 3 data reveals that about 1/4 of all such events contain limited regions where field lines appear to be either connected to the Sun at only one end or connected to the outer heliosphere at both ends. Similar intervals of open and disconnected field lines within CMEs have been identified in the Ulysses observations. We believe that these anomalous field topologies within CMEs are most naturally interpreted in terms of 3-dimensional reconnection behind CMEs close to the Sun. Such reconnection also provides a natural explanation both for the flux rope topology of many CMEs as well as the coronal loops formed during long-duration solar soft X ray events. Although detailed numerical simulations of 3-dimensional reconnection behind CMEs are not yet available, such simulations have been done for the qualitatively similar geometry that prevails within the geomagnetic tail. Those simulations of plasmoid formation in the geomagnetic tail do produce the mixture of field topologies within plasmoids discussed here for CMEs.

  9. The Virtual Mouse Brain: A Computational Neuroinformatics Platform to Study Whole Mouse Brain Dynamics.

    Science.gov (United States)

    Melozzi, Francesca; Woodman, Marmaduke M; Jirsa, Viktor K; Bernard, Christophe

    2017-01-01

    Connectome-based modeling of large-scale brain network dynamics enables causal in silico interrogation of the brain's structure-function relationship, necessitating the close integration of diverse neuroinformatics fields. Here we extend the open-source simulation software The Virtual Brain (TVB) to whole mouse brain network modeling based on individual diffusion magnetic resonance imaging (dMRI)-based or tracer-based detailed mouse connectomes. We provide practical examples on how to use The Virtual Mouse Brain (TVMB) to simulate brain activity, such as seizure propagation and the switching behavior of the resting state dynamics in health and disease. TVMB enables theoretically driven experimental planning and ways to test predictions in the numerous strains of mice available to study brain function in normal and pathological conditions.

  10. Connecting solutions in open string field theory with singular gauge transformations

    Czech Academy of Sciences Publication Activity Database

    Erler, Theodore; Maccaferri, C.

    2012-01-01

    Roč. 2012, č. 4 (2012), 1-40 ISSN 1126-6708 Grant - others:EUROHORC and ESF(XE) EYI/07/E010 Institutional research plan: CEZ:AV0Z10100502 Keywords : tachyon condensation * string field theory Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 5.618, year: 2012 http://link.springer.com/article/10.1007%2FJHEP04%282012%29107

  11. Open field release of genetically engineered sterile male Aedes aegypti in Malaysia.

    Directory of Open Access Journals (Sweden)

    Renaud Lacroix

    Full Text Available BACKGROUND: Dengue is the most important mosquito-borne viral disease. In the absence of specific drugs or vaccines, control focuses on suppressing the principal mosquito vector, Aedes aegypti, yet current methods have not proven adequate to control the disease. New methods are therefore urgently needed, for example genetics-based sterile-male-release methods. However, this requires that lab-reared, modified mosquitoes be able to survive and disperse adequately in the field. METHODOLOGY/PRINCIPAL FINDINGS: Adult male mosquitoes were released into an uninhabited forested area of Pahang, Malaysia. Their survival and dispersal was assessed by use of a network of traps. Two strains were used, an engineered 'genetically sterile' (OX513A and a wild-type laboratory strain, to give both absolute and relative data about the performance of the modified mosquitoes. The two strains had similar maximum dispersal distances (220 m, but mean distance travelled of the OX513A strain was lower (52 vs. 100 m. Life expectancy was similar (2.0 vs. 2.2 days. Recapture rates were high for both strains, possibly because of the uninhabited nature of the site. CONCLUSIONS/SIGNIFICANCE: After extensive contained studies and regulatory scrutiny, a field release of engineered mosquitoes was safely and successfully conducted in Malaysia. The engineered strain showed similar field longevity to an unmodified counterpart, though in this setting dispersal was reduced relative to the unmodified strain. These data are encouraging for the future testing and implementation of genetic control strategies and will help guide future field use of this and other engineered strains.

  12. Momentum-energy of the non-radiating electromagnetic field: open problems?

    International Nuclear Information System (INIS)

    Kholmetskii, Alexander L

    2006-01-01

    This paper inspects more closely the problem of the momentum and energy of a bound (non-radiative) electromagnetic (EM) field. It has been shown that for an isolating system of non-radiative non-relativistic mechanically free charged particles, a transformation of mechanical to EM momentum and vice versa occurs in accordance with the requirement P-vector G =const, where P-vector G = P-vector M + Σ i N q i A-vector i is the canonical momentum (N>1 is the number of particles, q is the charge, A-vector is the vector potential, P-vector M is the mechanical momentum of the system). Then dP-vector M /dt = -(d/dt)Σq i A-vector i represents the self-force, acting on this isolating system due to violation of Newton's third law in EM interaction. This equation is not applicable to an isolated charged particle, and the problems of its self-action and its own EM momentum have been examined. Analysing the systems of non-radiative particles, where the retardation is not negligible ('dynamical' systems in our definition) it has been found that the total momentum is the same at the initial and final stationary states of such systems, but it varies with time during the dynamical processes. It means a violation of continuous conservation of the total momentum, if the bound EM field spreads at the light velocity c. Finally, the compatibility of the energy conservation law and the Lentz rule for retarded non-radiative EM field has been examined. It has been shown that for dynamical systems the energy conservation law comes into a certain contradiction with the finite (light) spread velocity for the bound EM field

  13. Measurement of the surface field on open magnetic samples by the extrapolation method

    Czech Academy of Sciences Publication Activity Database

    Perevertov, Oleksiy

    2005-01-01

    Roč. 76, - (2005), 104701/1-104701/7 ISSN 0034-6748 R&D Projects: GA ČR(CZ) GP202/04/P010; GA AV ČR(CZ) 1QS100100508 Institutional research plan: CEZ:AV0Z10100520 Keywords : magnetic field measurement * extrapolation * air gaps * magnetic permeability Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.235, year: 2005

  14. Open area E.M. field measurements for radiation hazard purposes

    International Nuclear Information System (INIS)

    Bevacqua, F.; Cipollone, E.; Morviducci, A.; Venditti, L.

    1989-01-01

    This article reports on an extensive set of measurements of the E.M. pollution that has been done for radiation hazard purposes. The measurement results are compared with international standards, regulations and laws. Special attention is devoted to the measurement of the E.M. field near hospitals and some important remarks are made on risks related to induced errors on pacemarker and medial instrumentation

  15. Open Content in Open Context

    Science.gov (United States)

    Kansa, Sarah Whitcher; Kansa, Eric C.

    2007-01-01

    This article presents the challenges and rewards of sharing research content through a discussion of Open Context, a new open access data publication system for field sciences and museum collections. Open Context is the first data repository of its kind, allowing self-publication of research data, community commentary through tagging, and clear…

  16. [Effect of previous experience in reacting to a danger signal on "open field" behavior in the rat].

    Science.gov (United States)

    Poltyreva, T E; Petrov, E S

    1983-01-01

    Modification of rats behaviour in an "hopen field" test was investigated, induced by an acoustic stimulus, previously subjected to conditioning in a shuttle chamber in experiments with possibility and impossibility of avoidance from electrical shock. It has been established that presentation of a stimulus having the meaning of a danger signal, in a new situation, significantly suppresses investigating behaviour of rats, whereas the stimulus which had not been subjected to conditioning exerts no marked effect on behaviour. The greatest suppression was observed in rats with "learned helplessness". This fact suggests that the degree of suppression of the behaviour in an open field in response to a danger signal, depends on the animal's previous experience in reacting to this signal.

  17. Transient behavior of a flare-associated solar wind. I - Gas dynamics in a radial open field region

    Science.gov (United States)

    Nagai, F.

    1984-01-01

    A numerical investigation is conducted into the way in which a solar wind model initially satisfying both steady state and energy balance conditions is disturbed and deformed, under the assumption of heating that correspoonds to the energy release of solar flares of an importance value of approximately 1 which occur in radial open field regions. Flare-associated solar wind transient behavior is modeled for 1-8 solar radii. The coronal temperature around the heat source region rises, and a large thermal conductive flux flows inward to the chromosphere and outward to interplanetary space along field lines. The speed of the front of expanding chromospheric material generated by the impingement of the conduction front on the upper chromosphere exceeds the local sound velocity in a few minutes and eventually exceeds 100 million cm/sec.

  18. Relations between open-field, elevated plus-maze, and emergence tests in C57BL/6JIco and BALB/cAnN@Ico mice injected with ethanol.

    Science.gov (United States)

    Lalonde, R; Strazielle, C

    2012-04-01

    The effects of ethanol were examined on three tests of exploratory activity in two mouse strains. Although ethanol reduced open-field rearing in both strains, it increased ambulation only in the less active BALB/cAnN@Ico strain, not in the C57BL/6JIco strain. Likewise, ethanol increased open and enclosed arm entries in the elevated plus-maze only in the more anxious BALB/cAnN@Ico strain. However, both strains injected with ethanol emerged faster than placebo from a small chamber at doses not affecting behaviors in the other two tests. Significant correlations were found between emergence latencies on one hand and either slow stereotyped movements or open and enclosed arm entries on the other. The strain-specific effects may be attributable to differences in GABA(A) -related receptor binding or catalase activity. © 2011 The Authors Fundamental and Clinical Pharmacology © 2011 Société Française de Pharmacologie et de Thérapeutique.

  19. Initial behavior of a quantized scalar field and the associated pair-creation in several isotropic closed and open universes

    International Nuclear Information System (INIS)

    Nariai, Hidekazu.

    1981-01-01

    The concept of a positive frequency part near the initial epoch in a big-bang universe or its counterpart in other (say, de Sitter) one for a canonically quantized scalar field is important in discussing the associated pair-creation of those particles. Therefore, an attempt is made to define the positive frequency part in such isotropic closed and open universes that the scalar wave equation can be exactly solved. Except for some closed universe, the parts in question and, therefore, the Feynman propagators in the remaining universes are uniquely settled. Then it is shown that (1) the pair-creation in the Friedmann open universe (which is very interesting not only from observational, but also from theoretical viewpoints) is essentially equivalent to that in the Chitre-Hartle universe with flat 3-space and (2) the respective pair-creations in expanding metrics with open and flat 3-spaces of the de Sitter universe are different from each other, as insisted upon by Gibbons and Hawking basing on the original static metric. (author)

  20. Initial behavior of a quantized scalar field and the associated pair-creation in several isotropic closed and open universes

    International Nuclear Information System (INIS)

    Nariai, Hidekazu

    1982-01-01

    The concept of a positive frequency part near the initial epoch in a big-bang universe or its counterpart in other (say, de Sitter) one for a canonically quantized scalar field is important in discussing the associated pair-creation of those particles. Therefore, an attempt is made to define the positive frequency part in such isotropic closed and open universes that the scalar wave equation can be exactly solved. Except for some closed universe, the parts in question and, therefore, the Feynman propagators in the remaining universes are uniquely settled. Then it is shown that (1) the pair-creation in the Friedmann open universe (which is very interesting not only from observational, but also from theoretical viewpoints) is essentially equivalent to that in the Chitre-Hartle universe with flat 3-space and (2) the respective pair-creations in expanding metrics with open and flat 3-spaces of the de Sitter universe are different from each other, as insisted upon by Gibbons and Hawking basing on the original static metric. (author)

  1. Orthopedic and interventional applications at low field MRI with horizontally open configuration

    Energy Technology Data Exchange (ETDEWEB)

    Koskinen, S.K.; Parkkola, R.K.; Karhu, J.; Komu, M.E.S.; Kormano, M.J. [Diagnostic Radiology, Turku Univ. Hospital (Finland)

    1997-10-01

    The recently introduced horizontally open configuration imagers allow imaging of knee, hip or shoulder during whole range of motion, which is not possible in conventional MR imagers. Special joint motion devices can be used to provide accurate and reproducible studies. In cervical spine, functional MR imaging may be useful in evaluating alarligament stability in patients with late sequelae of a whiplash injury, and in patients with rheumatoid arthritis who are clinically suspected of having a cervical myelopathy or superior migration of the odontoid process. In shoulder, full range of motion abduction study may be helpful in assessing the supraspinatus tendon impingement. To evaluate patellofemoral malalignment, quadriceps loading is recommended since associated contracting muscles and related soft tissue structures can be evaluated. The position of the femoral head relative to the acetabulum during different positions can be assessed. Open-configuration scanners provide an access to patients during scanning procedure, and therefore permit interventional procedures to be monitored with MRI. Such interventions include aspiration cytology/biopsy and different drainage procedures. (orig.) [Deutsch] Die kuerzlich eingefuehrten bildgebenden Systeme mit horizontal offener Konfiguration ermoeglichen die Darstellung von Knie, Huefte oder Schulter ueber den gesamten Bewegungsbereich, war bisher mit konventionellen MR-Systemen nicht moeglich. Fuer genauere und reproduzierbare Untersuchungen koennen spezielle Gelenkbewegungsgeraete verwendet werden. Bei der Halswirbelsaeule kann die funktionelle NMR-Darstellung im Hinblick auf die Beurteilung der Stabilitaet der Ligamenta alaria bei Patienten mit Spaetfolgen eines Schleudertraumas und bei Patienten mit rheumatoider Arthritis von Nutzen sein, wenn klinisch eine zervikale Myelopathie oder superiore migration des Dens axis vermutet wird. Bei der Schulter kann eine Abduktionsstudie des vollen Bewegungsbereichs bei der Beurteilung

  2. Towards 2D field-flow fractionation - Vector separation over slanted open cavities

    Science.gov (United States)

    Bernate, Jorge A.; Yang, Mengfei; Zhao, Hong; Risbud, Sumedh; Paul, Colin; Dallas, Matthew; Konstantopoulos, Konstantinos; Drazer, German; Shaqfeh, Eric S. G.

    2013-11-01

    Planar microfluidic platforms for vector chromatography, in which different species fan out in different directions and can be continuously sorted, are particularly promising for the high throughput separation of multicomponent mixtures. We carry out a computational study of the vector separation of dilute suspensions of rigid and flexible particles transported by a pressure-driven flow over an array of slanted open cavities. The numerical scheme is based on a Stokes flow boundary integral equation method. The simulations are performed in a periodic system without lateral confinement, relevant to microfluidic devices with negligible recirculation in the main channel. We study the deflection of rigid spherical particles, of flexible capsules as a model of white and red blood cells, and of rigid discoidal particles as a model of platelets. We characterize the deflection of different particles as a function of their size, shape, shear elasticity, their release position, and the geometric parameters of the channel. The simulations provide insight into the separation mechanism and allow the optimization of specific devices depending on the application. Good agreement with experiments is observed.

  3. Open superstring field theory I: gauge fixing, ghost structure, and propagator

    Czech Academy of Sciences Publication Activity Database

    Kroyter, M.; Okawa, Y.; Schnabl, Martin; Torii, S.; Zwiebach, B.

    2012-01-01

    Roč. 2012, č. 3 (2012), 1-34 ISSN 1126-6708 R&D Projects: GA MŠk(CZ) LH11106 Grant - others:EUROHORC and ESF(XE) EYI/07/E010 Institutional research plan: CEZ:AV0Z10100502 Keywords : superstrings and heterotic strings * string field theory Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 5.618, year: 2012 http://link.springer.com/article/10.1007%2FJHEP03%282012%29030

  4. Subchronic Oral Bromocriptine Methanesulfonate Enhances Open Field Novelty-Induced Behavior and Spatial Memory in Male Swiss Albino Mice

    Directory of Open Access Journals (Sweden)

    Olakunle James Onaolapo

    2013-01-01

    Full Text Available This study set out to assess the neurobehavioral effects of subchronic, oral bromocriptine methanesulfonate using the open field and the Y-maze in healthy male mice. Sixty adult Swiss albino mice were assigned into three groups. Controls received normal saline, while test groups received bromocriptine methanesulfonate at 2.5 and 5 mg/kg/day, respectively, for a period of 21 days. Neurobehavioral tests were carried out on days 1 and 21 after administration. Open field assessment on day 1 after administration revealed significant increase in grooming at 2.5 and 5 mg/kg, while horizontal and vertical locomotion showed no significant changes. Day 1 also showed no significant changes in Y-maze alternation. On day 21, horizontal locomotion, rearing, and grooming were increased significantly at 2.5 and 5 mg/kg doses after administration; also, spatial memory was significantly enhanced at 2.5 mg/kg. In conclusion, the study demonstrates the ability of oral bromocriptine to affect neurobehavior in normal mice. It also suggests that there is a cumulative effect of oral bromocriptine on the behaviors studied with more changes being seen after subchronic administration rather than after a single oral dose.

  5. Seasonal variation of the impact of a stressful procedure on open field behaviour and blood corticosterone in laboratory mice.

    Science.gov (United States)

    Meyer, L; Caston, J; Mensah-Nyagan, A G

    2006-02-28

    Behavioural and hormonal seasonal changes are well documented in various vertebrate species living in their natural environment but circannual variations that may occur in laboratory animals reared in standard conditions are poorly investigated. This study shows that, in laboratory mice, the effects of stress on behavioural inhibition, investigatory behaviour and blood concentration of corticosterone are seasonally dependent. No consistency was observed between the reactivity of biological structures controlling the hormonal response to stress and the behavioural activities investigated at every period of the year. During the spring time, stress, which elicited a decrease of investigatory behaviour (estimated by the walking time in an open field), increased behavioural inhibition (estimated by the percentage of walking in the central area of the open field) as well as the blood corticosterone concentration in laboratory mice. In autumn, stress had no significant effect on behaviour despite the great hormonal concentration increase. The results reveal that, at certain period of the year, a stressful procedure is unable to affect behavioural parameters in laboratory mice which were maintained in constant 12-h dark/12-h light cycle. The report constitutes a novel piece of information suggesting a potential role of the endogenous biological clock in the modulation of stress response in mammals.

  6. Acute food deprivation separates motor-activating from anxiolytic effects of caffeine in a rat open field test model.

    Science.gov (United States)

    Schulz, Daniela

    2018-03-14

    Similar doses of caffeine have been shown to produce either anxiolytic or anxiogenic effects in rats. The reasons for these conflicting results are not known. We hypothesized that food deprivation stress interacts with the stimulant effects of caffeine to increase anxiety-like behavior. We tested 32 female Sprague Dawley rats in a dim open field for 10 min. Half of the animals were food deprived for 24 h and injected (intraperitoneal) with caffeine (30 mg/kg; n=7) or deionized water (n=8) 20 min before the open field test. The other half was nondeprived and injected with caffeine (30 mg/kg; n=8) or deionized water (n=9). Results showed that nondeprived rats injected with caffeine moved longer distances and at a greater speed in the periphery and moved longer distances and spent more time in the center than rats treated with vehicle, indicative of motor-activating and/or anxiolytic effects of caffeine. Rats that were food deprived and injected with caffeine moved longer distances in the center and tended to spend more time there, indicative of anxiolysis. We conclude that caffeine had two effects on behavior, motor activation and a reduction of anxiety, and that food deprivation separated these effects.

  7. Effects of clinically relevant doses of methyphenidate on spatial memory, behavioral sensitization and open field habituation: a time related study.

    Science.gov (United States)

    Haleem, Darakhshan Jabeen; Inam, Qurrat-ul-Aen; Haleem, Muhammad Abdul

    2015-03-15

    The psychostimulant methylphenidate (MPD) is a first-line drug for the treatment of attention deficit hyperactivity disorder (ADHD). Despite acceptable therapeutic efficacy, there is limited data regarding the long-term consequences of MPD exposure over extended periods. The present study concerns effects of clinically relevant doses of MPD, administered orally to rats for an extended period, on spatial memory, behavioral sensitization and habituation to an open field. Water maze test was used to monitor memory acquisition (2 h after training), retention (day next to training), extinction (1 week after training) and reconsolidation (weekly for 4 weeks). Administration of MPD at doses of 0.25-1.0 mg/kg improved memory acquisition, retention, reconsolidation and impaired memory extinction. Treatment with 0.25 and 0.5 mg/kg MPD for 6 weeks produced a sustained increase in motor activity but higher dose (1.0 mg/kg) elicited behavioral sensitization. High as well as low doses MPD impaired open field habituation. We conclude that clinically relevant doses of MPD enhance memory even if used for extended period. It is suggested that higher (1.0 mg/kg) clinically relevant doses of MPD, if used for extended period, may exacerbate hyperactivity and impulsivity associated with the disease. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. Effect of Wearing a Telemetry Jacket on Behavioral and Physiologic Parameters of Dogs in the Open-Field Test.

    Science.gov (United States)

    Fish, Richard E; Foster, Melanie L; Gruen, Margaret E; Sherman, Barbara L; Dorman, Davidc C

    2017-07-01

    Safety pharmacology studies in dogs often integrate behavioral assessments made using video recording with physiologic measurements collected by telemetry. However, whether merely wearing the telemetry vest affects canine behavior and other parameters has not been evaluated. This pilot study assessed the effect of a telemetry vest on behavioral and physiologic responses to an environmental stressor, the sounds of a thunderstorm, in Labrador retrievers. Dogs were assigned to one of 2 experimental groups (Vest and No-Vest, n = 8 dogs per group) by using a matched pairs design, with a previously determined, sound-associated anxiety score as the blocking variable. Dogs were individually retested with the same standardized sound stimulus (thunderstorm) in an open-field arena, and their behavioral responses were video recorded. Video analysis of locomotor activity and anxiety-related behavior and manual determination of heart rate and body temperature were performed; results were compared between groups. Vest wearing did not affect total locomotor activity or rectal body temperature but significantly decreased heart rate by 8% and overall mean anxiety score by 34% during open-field test sessions. Our results suggest that the use of telemetry vests in dogs influences the measurement of physiologic parameters and behaviors that are assessed in safety pharmacology studies.

  9. Subchronic Oral Bromocriptine Methanesulfonate Enhances Open Field Novelty-Induced Behavior and Spatial Memory in Male Swiss Albino Mice.

    Science.gov (United States)

    Onaolapo, Olakunle James; Onaolapo, Adejoke Yetunde

    2013-01-01

    This study set out to assess the neurobehavioral effects of subchronic, oral bromocriptine methanesulfonate using the open field and the Y-maze in healthy male mice. Sixty adult Swiss albino mice were assigned into three groups. Controls received normal saline, while test groups received bromocriptine methanesulfonate at 2.5 and 5 mg/kg/day, respectively, for a period of 21 days. Neurobehavioral tests were carried out on days 1 and 21 after administration. Open field assessment on day 1 after administration revealed significant increase in grooming at 2.5 and 5 mg/kg, while horizontal and vertical locomotion showed no significant changes. Day 1 also showed no significant changes in Y-maze alternation. On day 21, horizontal locomotion, rearing, and grooming were increased significantly at 2.5 and 5 mg/kg doses after administration; also, spatial memory was significantly enhanced at 2.5 mg/kg. In conclusion, the study demonstrates the ability of oral bromocriptine to affect neurobehavior in normal mice. It also suggests that there is a cumulative effect of oral bromocriptine on the behaviors studied with more changes being seen after subchronic administration rather than after a single oral dose.

  10. [Influence of 1, 2-dichloroethane on open field behavior and levels of neurotransmitters in brain of mice].

    Science.gov (United States)

    Qi, Ying; Shi, Lei; Gao, Lan-Yue; Wang, Gao-Yang; Li, Ge-Xin; Lv, Xiu-Qiang; Jin, Ya-Ping

    2011-06-01

    To explore the effects of 1,2-dichloroethane (1,2-DCE) on the behavior and the brain neurotransmitter levels in mice. Thirty mice were randomly divided into four groups, which were control group and groups of low, middle and high exposure (225, 450 and 900 mg/m3) to 1,2-DCE for 10 days (3.5 h a day) by inhalation. After the last exposure, the open field test was performed immediately. After exposure all mice were killed and the brain tissues were taken up rapidly. The levels of aspartate (Asp), glutamate (Glu) and gamma-aminobutyric acid (GABA) in the brain were detected by high performance liquid chromatography (HPLC). Levels of Asp and Glu in all exposure groups increased with doses. As compared to the control group, levels of Glu in all exposure groups increased significantly (P open field test showed that effect of low exposure to 1,2-DCE on the behavior was stimulant, but the high exposure to 1,2-DCE inhibited behavior of exploration, excitement and sport. Subacute exposure to 1,2-DCE could result in the change of amino acid neurotransmitter content and ratio in the brain, thereby change the behavior of mice appeared, which might be the mechanism of neurotoxicity caused by 1,2-DCE in part.

  11. Field portable low temperature porous layer open tubular cryoadsorption headspace sampling and analysis part I: Instrumentation.

    Science.gov (United States)

    Bruno, Thomas J

    2016-01-15

    Building on the successful application in the laboratory of PLOT-cryoadsorption as a means of collecting vapor (or headspace) samples for chromatographic analysis, in this paper a field portable apparatus is introduced. This device fits inside of a briefcase (aluminum tool carrier), and can be easily transported by vehicle or by air. The portable apparatus functions entirely on compressed air, making it suitable for use in locations lacking electrical power, and for use in flammable and explosive environments. The apparatus consists of four aspects: a field capable PLOT-capillary platform, the supporting equipment platform, the service interface between the PLOT-capillary and the supporting equipment, and the necessary peripherals. Vapor sampling can be done with either a hand piece (containing the PLOT capillary) or with a custom fabricated standoff module. Both the hand piece and the standoff module can be heated and cooled to facilitate vapor collection and subsequent vapor sample removal. The service interface between the support platform and the sampling units makes use of a unique counter current approach that minimizes loss of cooling and heating due to heat transfer with the surroundings (recuperative thermostatting). Several types of PLOT-capillary elements and sampling probes are described in this report. Applications to a variety of samples relevant to forensic and environmental analysis are discussed in a companion paper. Published by Elsevier B.V.

  12. Differences between Non-arteritic Anterior Ischemic Optic Neuropathy and Open Angle Glaucoma with Altitudinal Visual Field Defect.

    Science.gov (United States)

    Han, Sangyoun; Jung, Jong Jin; Kim, Ungsoo Samuel

    2015-12-01

    To investigate the differences in retinal nerve fiber layer (RNFL) change and optic nerve head parameters between non-arteritic anterior ischemic optic neuropathy (NAION) and open angle glaucoma (OAG) with altitudinal visual field defect. Seventeen NAION patients and 26 OAG patients were enrolled prospectively. The standard visual field indices (mean deviation, pattern standard deviation) were obtained from the Humphrey visual field test and differences between the two groups were analyzed. Cirrus HD-OCT parameters were used, including optic disc head analysis, average RNFL thickness, and RNFL thickness of each quadrant. The mean deviation and pattern standard deviation were not significantly different between the groups. In the affected eye, although the disc area was similar between the two groups (2.00 ± 0.32 and 1.99 ± 0.33 mm(2), p = 0.586), the rim area of the OAG group was smaller than that of the NAION group (1.26 ± 0.56 and 0.61 ± 0.15 mm(2), respectively, p field defects, optic disc head analysis of not only the affected eye, but also the unaffected eye, by using spectral domain optical coherence tomography may be helpful.

  13. Behaviour parameters of rats in the 'Open field' test under combined effect of radiation and non-radiation factors

    International Nuclear Information System (INIS)

    Kadukova, E.M.; Stashkevich, D.G.; Naumov, A.D.; Kuts, F.I.

    2015-01-01

    It was shown that exposure of electromagnetic radiation and emotional stress modifies the level of integrative reaction of CNS rats which were exposed to ionizing radiation in the 'Open field' test. (authors)

  14. Manual versus Automated Rodent Behavioral Assessment: Comparing Efficacy and Ease of Bederson and Garcia Neurological Deficit Scores to an Open Field Video-Tracking System.

    Science.gov (United States)

    Desland, Fiona A; Afzal, Aqeela; Warraich, Zuha; Mocco, J

    2014-01-01

    Animal models of stroke have been crucial in advancing our understanding of the pathophysiology of cerebral ischemia. Currently, the standards for determining neurological deficit in rodents are the Bederson and Garcia scales, manual assessments scoring animals based on parameters ranked on a narrow scale of severity. Automated open field analysis of a live-video tracking system that analyzes animal behavior may provide a more sensitive test. Results obtained from the manual Bederson and Garcia scales did not show significant differences between pre- and post-stroke animals in a small cohort. When using the same cohort, however, post-stroke data obtained from automated open field analysis showed significant differences in several parameters. Furthermore, large cohort analysis also demonstrated increased sensitivity with automated open field analysis versus the Bederson and Garcia scales. These early data indicate use of automated open field analysis software may provide a more sensitive assessment when compared to traditional Bederson and Garcia scales.

  15. Manual versus Automated Rodent Behavioral Assessment: Comparing Efficacy and Ease of Bederson and Garcia Neurological Deficit Scores to an Open Field Video-Tracking System

    Directory of Open Access Journals (Sweden)

    Fiona A. Desland

    2014-01-01

    Full Text Available Animal models of stroke have been crucial in advancing our understanding of the pathophysiology of cerebral ischemia. Currently, the standards for determining neurological deficit in rodents are the Bederson and Garcia scales, manual assessments scoring animals based on parameters ranked on a narrow scale of severity. Automated open field analysis of a live-video tracking system that analyzes animal behavior may provide a more sensitive test. Results obtained from the manual Bederson and Garcia scales did not show significant differences between pre- and post-stroke animals in a small cohort. When using the same cohort, however, post-stroke data obtained from automated open field analysis showed significant differences in several parameters. Furthermore, large cohort analysis also demonstrated increased sensitivity with automated open field analysis versus the Bederson and Garcia scales. These early data indicate use of automated open field analysis software may provide a more sensitive assessment when compared to traditional Bederson and Garcia scales.

  16. FEATURES OF MINERAL NUTRITION FOR TOMATO PLANTS WITH DRIP IRRIGATION SYSTEM IN OPEN FIELD CONDITION

    Directory of Open Access Journals (Sweden)

    P. M. Akhmetova

    2017-01-01

    Full Text Available Dagestan is the largest region with irrigation system of agriculture in Russia. Irrigated lands provide 70% of total plant production. The field cultivation is carried on arable land in plain region of the republic. The drip irrigation as an ecologically safe technology for watering is regarded as major means for vegetable production farming. This approach maintains the propitious level of water and air in the soil without surface and deep drainage of irrigating water. These irrigated lands are expected to be used first of all for valuable and profitable crops such as tomato that is a leading crop in Dagestan. The experimental work was carried out at OOO ‘Dagagrocomplex’, Aleksandro-Nevskoye, in Tarumovskiy region. The aim of the study was to determinate the optimal dose of mineral fertilizers and the way of their application to improve the productivity without quality loss. The complex analysis of the technology for tomato production under drip irrigation through nontransplanting culture showed its high efficiency, because volume and quality of yield directly depended on soil moisture and precise supporting of mineral nutrition rates. The maximal yield of tomato fruits, 88.7-94.5 t/ha was observed with once mineral fertilizer application at a dose of N180P135K60 with soil humidity 70-80% (field moisture capacity, and also at the dose of N180P135K60 with basic application of N100 in nutrition rate. The result of the study showed that the optimization of two factors, namely soil water rate and mineral nutrition, enabled to produce additionally 39.2 t/ha. It was shown the tight connection between yielding and its quality; when yielding 95 t/ha, the increased contents of dry matter to 7.01%, sugar to 3.8% vitamin C to 18.46% were noticed. The high quality of produced output was supported by pre-watering threshold of moisture at 75-80% (field moisture capacity, when once fertilizer application at a dose of N180P135K60. 

  17. An Application-oriented Open Software Platform for Multi-purpose Field Robotics

    DEFF Research Database (Denmark)

    Jensen, Kjeld

    that solve simple tasks such as mowing, and automatic tractor steering that navigates through a planned route under the supervision of an operator. The outdoor environment in which the robot operates is often very complex. This places great demands on the robot's ability to perceive the environment and based...... on this behave in a way that is appropriate and productive with respect to the given task while being safe for nearby people, animals and objects. Researchers are challenged by the considerable resources required to develop robot software capable of supporting experiments in such a complex perception...... and behavior. The lack of collaboration between research groups contributes to the problem, the scientific publications describe methods and results from the work, but little software for field robots are released and documented for use by others. The hypothesis of this work is that an application oriented...

  18. Improvements of high-power diode laser line generators open up new application fields

    Science.gov (United States)

    Meinschien, J.; Bayer, A.; Bruns, P.; Aschke, L.; Lissotschenko, V. N.

    2009-02-01

    Beam shaping improvements of line generators based on high power diode lasers lead to new application fields as hardening, annealing or cutting of various materials. Of special interest is the laser treatment of silicon. An overview of the wide variety of applications is presented with special emphasis of the relevance of unique laser beam parameters like power density and beam uniformity. Complementary to vision application and plastic processing, these new application markets become more and more important and can now be addressed by high power diode laser line generators. Herewith, a family of high power diode laser line generators is presented that covers this wide spectrum of application fields with very different requirements, including new applications as cutting of silicon or glass, as well as the beam shaping concepts behind it. A laser that generates a 5m long and 4mm wide homogeneous laser line is shown with peak intensities of 0.2W/cm2 for inspection of railway catenaries as well as a laser that generates a homogeneous intensity distribution of 60mm x 2mm size with peak intensities of 225W/cm2 for plastic processing. For the annealing of silicon surfaces, a laser was designed that generates an extraordinary uniform intensity distribution with residual inhomogeneities (contrast ratio) of less than 3% over a line length of 11mm and peak intensities of up to 75kW/cm2. Ultimately, a laser line is shown with a peak intensity of 250kW/cm2 used for cutting applications. Results of various application tests performed with the above mentioned lasers are discussed, particularly the surface treatment of silicon and the cutting of glass.

  19. First field demonstration of cloud datacenter workflow automation employing dynamic optical transport network resources under OpenStack and OpenFlow orchestration.

    Science.gov (United States)

    Szyrkowiec, Thomas; Autenrieth, Achim; Gunning, Paul; Wright, Paul; Lord, Andrew; Elbers, Jörg-Peter; Lumb, Alan

    2014-02-10

    For the first time, we demonstrate the orchestration of elastic datacenter and inter-datacenter transport network resources using a combination of OpenStack and OpenFlow. Programmatic control allows a datacenter operator to dynamically request optical lightpaths from a transport network operator to accommodate rapid changes of inter-datacenter workflows.

  20. A Navigation Analysis Tool (NAT) to assess spatial behavior in open-field and structured mazes.

    Science.gov (United States)

    Jarlier, Frédéric; Arleo, Angelo; Petit, Géraldine H; Lefort, Julie M; Fouquet, Céline; Burguière, Eric; Rondi-Reig, Laure

    2013-05-15

    Spatial navigation calls upon mnemonic capabilities (e.g. remembering the location of a rewarding site) as well as adaptive motor control (e.g. fine tuning of the trajectory according to the ongoing sensory context). To study this complex process by means of behavioral measurements it is necessary to quantify a large set of meaningful parameters on multiple time scales (from milliseconds to several minutes), and to compare them across different paradigms. Moreover, the issue of automating the behavioral analysis is critical to cope with the consequent computational load and the sophistication of the measurements. We developed a general purpose Navigation Analysis Tool (NAT) that provides an integrated architecture consisting of a data management system (implemented in MySQL), a core analysis toolbox (in MATLAB), and a graphical user interface (in JAVA). Its extensive characterization of trajectories over time, from exploratory behavior to goal-oriented navigation with decision points using a wide range of parameters, makes NAT a powerful analysis tool. In particular, NAT supplies a new set of specific measurements assessing performances in multiple intersection mazes and allowing navigation strategies to be discriminated (e.g. in the starmaze). Its user interface enables easy use while its modular organization provides many opportunities of extension and customization. Importantly, the portability of NAT to any type of maze and environment extends its exploitation far beyond the field of spatial navigation. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. Comparing Natural Gas Leakage Detection Technologies Using an Open-Source "Virtual Gas Field" Simulator.

    Science.gov (United States)

    Kemp, Chandler E; Ravikumar, Arvind P; Brandt, Adam R

    2016-04-19

    We present a tool for modeling the performance of methane leak detection and repair programs that can be used to evaluate the effectiveness of detection technologies and proposed mitigation policies. The tool uses a two-state Markov model to simulate the evolution of methane leakage from an artificial natural gas field. Leaks are created stochastically, drawing from the current understanding of the frequency and size distributions at production facilities. Various leak detection and repair programs can be simulated to determine the rate at which each would identify and repair leaks. Integrating the methane leakage over time enables a meaningful comparison between technologies, using both economic and environmental metrics. We simulate four existing or proposed detection technologies: flame ionization detection, manual infrared camera, automated infrared drone, and distributed detectors. Comparing these four technologies, we found that over 80% of simulated leakage could be mitigated with a positive net present value, although the maximum benefit is realized by selectively targeting larger leaks. Our results show that low-cost leak detection programs can rely on high-cost technology, as long as it is applied in a way that allows for rapid detection of large leaks. Any strategy to reduce leakage should require a careful consideration of the differences between low-cost technologies and low-cost programs.

  2. Effective field theory approach to open heavy flavor production in heavy-ion collisions

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Zhong-Bo [Department of Physics and Astronomy, University of California,Los Angeles, California 90095 (United States); Mani L. Bhaumik Institute for Theoretical Physics, University of California,Los Angeles, California 90095 (United States); Theoretical Division, Los Alamos National Laboratory,Los Alamos, New Mexico 87545 (United States); Ringer, Felix; Vitev, Ivan [Theoretical Division, Los Alamos National Laboratory,Los Alamos, New Mexico 87545 (United States)

    2017-03-28

    We develop a version of Soft Collinear Effective Theory (SCET) which includes finite quark masses, as well as Glauber gluons that describe the interaction of collinear partons with QCD matter. In the framework of this new effective field theory, labeled SCET{sub M,G}, we derive the massive splitting functions in the vacuum and the QCD medium for the processes Q→Qg, Q→gQ and g→QQ̄. The numerical effects due to finite quark masses are sizable and our results are consistent with the traditional approach to parton energy loss in the soft gluon emission limit. In addition, we present a new framework for including the medium-induced full splitting functions consistent with next-to-leading order calculations in QCD for inclusive hadron production. Finally, we show numerical results for the suppression of D- and B-mesons in heavy ion collisions at √(s{sub NN})=5.02 TeV and 2.76 TeV and compare to available data from the LHC.

  3. Selective Deletion of Sodium Salt Taste during Development Leads to Expanded Terminal Fields of Gustatory Nerves in the Adult Mouse Nucleus of the Solitary Tract.

    Science.gov (United States)

    Sun, Chengsan; Hummler, Edith; Hill, David L

    2017-01-18

    Neuronal activity plays a key role in the development of sensory circuits in the mammalian brain. In the gustatory system, experimental manipulations now exist, through genetic manipulations of specific taste transduction processes, to examine how specific taste qualities (i.e., basic tastes) impact the functional and structural development of gustatory circuits. Here, we used a mouse knock-out model in which the transduction component used to discriminate sodium salts from other taste stimuli was deleted in taste bud cells throughout development. We used this model to test the hypothesis that the lack of activity elicited by sodium salt taste impacts the terminal field organization of nerves that carry taste information from taste buds to the nucleus of the solitary tract (NST) in the medulla. The glossopharyngeal, chorda tympani, and greater superficial petrosal nerves were labeled to examine their terminal fields in adult control mice and in adult mice in which the α-subunit of the epithelial sodium channel was conditionally deleted in taste buds (αENaC knockout). The terminal fields of all three nerves in the NST were up to 2.7 times greater in αENaC knock-out mice compared with the respective field volumes in control mice. The shapes of the fields were similar between the two groups; however, the density and spread of labels were greater in αENaC knock-out mice. Overall, our results show that disruption of the afferent taste signal to sodium salts disrupts the normal age-dependent "pruning" of all terminal fields, which could lead to alterations in sensory coding and taste-related behaviors. Neural activity plays a major role in the development of sensory circuits in the mammalian brain. To date, there has been no direct test of whether taste-elicited neural activity has a role in shaping central gustatory circuits. However, recently developed genetic tools now allow an assessment of how specific taste stimuli, in this case sodium salt taste, play a role

  4. The technique of MRT aided abdominal drainage using an open low field magnet. Feasibility and first results

    International Nuclear Information System (INIS)

    Gehl, H.B.; Frahm, C.; Schimmelpenning, H.; Weiss, H.D.

    1996-01-01

    To test the practicality of MRT-aided drainage using an open low field magnet and to report on the early clinical results. So far seven patients have been treated (four subphrenic abscesses, two psoas abscesses and one pancreatic pseudocyst). The planning of the approach and catheter insertion were carried out under MRT control (Magnetom Open, 0.2 T). Subsequent treatment was controlled by CT and fluoroscopy. Initial puncture was carried out with a non-magnetic 18 gauge Chiba needle. The drainage catheter was introduced by Seldinger's technique in six cases and with a trocar in one patient. In all seven patients drainage could be started successfully. The design of the magnet and coils permitted adequate accessibility of the patient. There were no problems in visualising the puncture needle. Controlling the position of the catheter by MRT was, however, difficult. The first two steps in abscess drainage (planning the approach and inserting the catheter) can be carried out under MRT control. For further catheter control and observing the course of the disease we presently prefer CT or fluoroscopy. (orig.) [de

  5. Open-source LCA tool for estimating greenhouse gas emissions from crude oil production using field characteristics.

    Science.gov (United States)

    El-Houjeiri, Hassan M; Brandt, Adam R; Duffy, James E

    2013-06-04

    Existing transportation fuel cycle emissions models are either general and calculate nonspecific values of greenhouse gas (GHG) emissions from crude oil production, or are not available for public review and auditing. We have developed the Oil Production Greenhouse Gas Emissions Estimator (OPGEE) to provide open-source, transparent, rigorous GHG assessments for use in scientific assessment, regulatory processes, and analysis of GHG mitigation options by producers. OPGEE uses petroleum engineering fundamentals to model emissions from oil and gas production operations. We introduce OPGEE and explain the methods and assumptions used in its construction. We run OPGEE on a small set of fictional oil fields and explore model sensitivity to selected input parameters. Results show that upstream emissions from petroleum production operations can vary from 3 gCO2/MJ to over 30 gCO2/MJ using realistic ranges of input parameters. Significant drivers of emissions variation are steam injection rates, water handling requirements, and rates of flaring of associated gas.

  6. Transient behavior of flare-associated solar wind. II - Gas dynamics in a nonradial open field region

    Science.gov (United States)

    Nagai, F.

    1984-01-01

    Transient behavior of flare-associated solar wind in the nonradial open field region is numerically investigated, taking into account the thermal and dynamical coupling between the chromosphere and the corona. A realistic steady solar wind is constructed which passes through the inner X-type critical point in the rapidly diverging region. The wind speed shows a local maximum at the middle, O-type, critical point. The wind's density and pressure distributions decrease abruptly in the rapidly diverging region of the flow tube. The transient behavior of the wind following flare energy deposition includes ascending and descending conduction fronts. Thermal instability occurs in the lower corona, and ascending material flows out through the throat after the flare energy input ceases. A local density distribution peak is generated at the shock front due to the pressure deficit just behind the shock front.

  7. MR-Guided Laser Ablation of Osteoid Osteoma in an Open High-Field System (1.0 T)

    International Nuclear Information System (INIS)

    Streitparth, F.; Gebauer, B.; Melcher, I.; Schaser, K.; Philipp, C.; Rump, J.; Hamm, B.; Teichgraeber, U.

    2009-01-01

    Computed tomography is the standard imaging modality to minimize the extent of surgical or ablative treatment in osteoid osteomas. In the last 15 years, since a description of thermal ablation of osteoid osteomas was first published, this technique has become a treatment of choice for this tumor. We report the case of a 20-year-old man with an osteoid osteoma treated with laser ablation in an open high-field magnetic resonance imaging scanner (1.0 T). The tumor, located in the right fibula, was safely and effectively ablated under online monitoring. We describe the steps of this interventional procedure and discuss related innovative guidance and monitoring features and potential benefits compared with computed tomographic guidance.

  8. Effect of perinatal lead exposure on rat behaviour in open-field and two-way avoidance tasks

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, A.L.S. [Federal Univ. of Santa Catarina, Center of Biological Sciences, Dept. of Biochemistry, Florianopolis, SC (Brazil); Rocha, J.B.T.; Mello, C.F. [Federal Univ. of Santa Maria, Dept. of Chemistry, Santa Maria, RS (Brazil); Souza, D.O. [Federal Univ. of Rio Grande do Sul, Biosciences Inst., Dept. of Biochemistry, Porto Alegre, RS (Brazil)

    1996-09-01

    In view of conflicting results in literature concerning lead exposure associated with behavioural alterations, this study investigated behaviour in the open-field and shuttle avoidance, for as well as tissue lead burdens of pre- and postnatally lead-exposed rats. Rats were exposed to the metal from conception to weaning by giving the dams 0.5, 2.0 or 4.0 mM lead acetate in drinking water. This regimen did not affect body weight gain of dams or offspring development and had no effect on cerebral weights nor on haematological parameters of 23-day-old rats. In 1-day-old rats, lead accumulated in the blood but not in the brain, whereas both in 23-day-old rats and in dams lead accumulated in blood, kidney and cerebral cortex. In the open-field, lead-exposed groups showed higher locomotor activity in the test session as compared to controls and did not show any decrease in rearing responses in the test, indicating less habituation. Lead-treated rats subjected to a shuttle avoidance task showed no significant increase in avoidance responses between sessions as compared to control, indicating less retention. Moreover, only the control group presented a significant reduction of the footshock escape latency along testing session, suggesting a lead effect on footshock escape acquisition. In the shuttle box, intertrial crossing responses were not affected by lead treatment. The behavioural alterations occurred in animals with blood lead levels in the range 11-50.6 {mu}g/dl. (au) 34 refs.

  9. Sex- and Age-dependent Effects of Orexin 1 Receptor Blockade on Open-Field Behavior and Neuronal Activity.

    Science.gov (United States)

    Blume, Shannon R; Nam, Hannah; Luz, Sandra; Bangasser, Debra A; Bhatnagar, Seema

    2018-06-15

    Adolescence is a sensitive and critical period in brain development where psychiatric disorders such as anxiety, depression and post-traumatic stress disorder are more likely to emerge following a stressful life event. Females are two times more likely to suffer from psychiatric disorders than males. Patients with these disorders show alterations in orexins (also called hypocretins), important neuropeptides that regulate arousal, wakefulness and the hypothalamic-pituitary-adrenal axis activity. Little is known on the role of orexins in mediating arousal behaviors in male and female rats during adolescence or adulthood. Here, we examine the influence of orexin 1 receptor blockade by SB334867 in open-field behavior in male and female rats during early adolescence (PND 31-33) or adulthood (PND 75-77). Animals were injected with 0 (vehicle), 1, 10, or 30 mg/kg SB334867 (i.p.). Thirty minutes later, they were placed in an open field, and behavior and neuronal activity (c-Fos) were assessed. In adolescent males, SB334867 significantly increased immobility in the 10 mg/kg group compared to vehicle. However, this increase in immobility in adolescent males was not observed in adolescent females. In contrast to adolescent males, adult males in the 10 mg/kg dose group showed the opposite effect on immobility compared to vehicle. These results indicate that 10 mg/kg dose of SB334867 has opposing effects in adolescent and adult males, but few effects in adolescent and adult females. Differences in functional networks between limbic regions may underlie these effects of orexin receptor blockade that are sex- and age-dependent in rats. Copyright © 2018 IBRO. Published by Elsevier Ltd. All rights reserved.

  10. Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma

    Directory of Open Access Journals (Sweden)

    Naito T

    2015-11-01

    Full Text Available Tomoko Naito,1 Keiji Yoshikawa,2 Shiro Mizoue,3 Mami Nanno,4 Tairo Kimura,5 Hirotaka Suzumura,6 Ryuji Takeda,7 Fumio Shiraga1 1Department of Ophthalmology, Okayama University Graduate School of Medicine, Okayama, 2Yoshikawa Eye Clinic, Tokyo, 3Department of Ophthalmology, Ehime University Graduate School of Medicine, Ehime, 4Kagurazaka Minamino Eye Clinic, 5Ueno Eye Clinic, 6Suzumura Eye Clinic, Tokyo, 7Department of Agriculture, Kinki University, Nara, Japan Purpose: To analyze the relationship between consecutive deterioration of mean deviation (MD value and glaucomatous visual field (VF progression in open-angle glaucoma (OAG, including primary OAG and normal tension glaucoma.Patients and methods: The subjects of the study were patients undergoing treatment for OAG who had performed VF tests at least 10 times with a Humphrey field analyzer (SITA standard, C30-2 program. The VF progression was defined by a significantly negative MD slope (MD slope worsening at the final VF test during the follow-up period. The relationship between the MD slope worsening and the consecutive deterioration of MD value were retrospectively analyzed.Results: A total of 165 eyes of 165 patients were included in the analysis. Significant progression of VF defects was observed in 72 eyes of 72 patients (43.6%, while no significant progression was evident in 93 eyes of 93 patients (56.4%. There was significant relationship between the frequency of consecutive deterioration of MD value and MD slope worsening (P<0.0001, Cochran–Armitage trend test. A significant association was observed for MD slope worsening in the eyes with three (odds ratio: 2.1, P=0.0224 and four (odds ratio: 3.6, P=0.0008 consecutive deterioration of MD value in multiple logistic regression analysis, but no significant association in the eyes with two consecutive deterioration (odds ratio: 1.1, P=0.8282. The eyes with VF progression had significantly lower intraocular pressure reduction rate (P<0

  11. Progression of visual field in patients with primary open-angle glaucoma - ProgF study 1.

    Science.gov (United States)

    Aptel, Florent; Aryal-Charles, Nishal; Giraud, Jean-Marie; El Chehab, Hussam; Delbarre, Maxime; Chiquet, Christophe; Romanet, Jean-Paul; Renard, Jean-Paul

    2015-12-01

    To evaluate the visual field rate of progression of patients with treated ocular hypertension (OHT) and primary open-angle glaucoma (POAG) in clinical practice, using the mean deviation (MD) and the visual field index (VFI). Non-interventional cohort study. From a large multicentre database representative of the French population, 441 eyes of 228 patients with treated OHT or POAG followed up at least 6 years with Humphrey 24.2 Sita-Standard visual field examination at least twice a year were identified. From initial data, eyes were classified in five groups: 121 with OHT, 188 with early glaucoma (MD greater than -6 dB), 45 with moderate glaucoma (MD -6 to -12 dB), 41 with advanced glaucoma (MD -12 to -18 dB) and 46 with severe glaucoma (MD less than -18 dB). Rate of progression during the follow-up period was calculated using the trend analysis of the Guided Progression Analysis software. The mean duration of follow-up was 8.4 ± 2.7 years and the mean number of visual field, 18.4 ± 3.5. In eyes with OHT, rate of progression was -0.09 dB/year (-0.17%VFI/year). In eyes with POAG, rate of progression was -0.32 dB/year (-0.83%VFI/year) in eyes with early glaucoma, -0.52 dB/year (-1.81%VFI/year) in moderate glaucoma, -0.54 dB/year (-2.35%VFI/year) in advanced glaucoma and -0.45 dB/year (-1.97%VFI/year) in severe glaucoma. In eyes with POAG, a significant progression (p open-angle glaucoma is a progressive disease in the majority of patients despite cautioned treatment and follow-up. The rate of progression varies greatly among subjects. © 2015 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

  12. Lessons in modern digital field geology: Open source software, 3D techniques, and the new world of digital mapping

    Science.gov (United States)

    Pavlis, Terry; Hurtado, Jose; Langford, Richard; Serpa, Laura

    2014-05-01

    Although many geologists refuse to admit it, it is time to put paper-based geologic mapping into the historical archives and move to the full potential of digital mapping techniques. For our group, flat map digital geologic mapping is now a routine operation in both research and instruction. Several software options are available, and basic proficiency with the software can be learned in a few hours of instruction and practice. The first practical field GIS software, ArcPad, remains a viable, stable option on Windows-based systems. However, the vendor seems to be moving away from ArcPad in favor of mobile software solutions that are difficult to implement without GIS specialists. Thus, we have pursued a second software option based on the open source program QGIS. Our QGIS system uses the same shapefile-centric data structure as our ArcPad system, including similar pop-up data entry forms and generic graphics for easy data management in the field. The advantage of QGIS is that the same software runs on virtually all common platforms except iOS, although the Android version remains unstable as of this writing. A third software option we are experimenting with for flat map-based field work is Fieldmove, a derivative of the 3D-capable program Move developed by Midland Valley. Our initial experiments with Fieldmove are positive, particularly with the new, inexpensive (potential for communicating the complexity of key exposures. For example, in studies of metamorphic structures we often search for days to find "Rosetta Stone" outcrops that display key geometric relationships. While conventional photographs rarely can capture the essence of the field exposure, capturing a true 3D representation of the exposure with multiple photos from many orientations can solve this communication problem. As spatial databases evolve these 3D models should be readily importable into the database.

  13. Control of the Tomato Leafminer, Tuta absoluta (Lepidoptera: Gelechiidae), in Open-Field Tomatoes by Indigenous Natural Enemies Occurring in Israel.

    Science.gov (United States)

    Shaltiel-Harpaz, Liora; Gerling, Dan; Graph, Shaul; Kedoshim, Hendrika; Azolay, Lotem; Rozenberg, Tamir; Nachache, Yaakov; Steinberg, Shimon; Allouche, Arnon; Alon, Tamar

    2016-02-01

    The tomato leafminer, Tuta absoluta (Meyrick), had established in Israel by 2010, attacking both open-field tomatoes and greenhouse crops.We searched for its natural enemies in open-field tomatoes, and tried to determine their potential for controlling this pest. We surveyed the local natural enemies in open tomato fields and measured their impact on pest populations in an unsprayed field. We assessed the suppressive ability of the dominant hemipteran predator, Nesidiocoris tenuis Reuter, against T. absoluta under controlled laboratory conditions and evaluated the impact of its augmentation on T. absoluta control in open-field tomatoes. We found five natural enemy species:the predator, N. tenuis, two braconids, and two eulophids. Predation accounted for 64.5±9.2% (mean ± SE) of T. absoluta larval mortality, whereas parasitism accounted for 20.96±7.5%. Together, they eliminated the pest population at tomato harvest time. Under controlled conditions, predation by N. tenuis rose from 58 to 72% with increased density of T. absoluta, suggesting positive density dependence. The reduction of T. absoluta (83%) by N. tenuis was higher than that of Bemisia tabaci (32%), suggesting a preference of N. tenuis for T. absoluta. Augmentation of N.tenuis was as effective as conventional treatment insecticide treatment, and plant damage was low and did not seem to affect yield. Results indicate that reduced pesticide use enables indigenous natural enemies, particularly N.tenuis, to successfully control T. absoluta and prevent crop damage in open-field tomatoes.

  14. Hybrid Simulation of Supersonic Flow of Weakly Ionized Plasma along Open Field Magnetic Line Effect of Background Pressure

    Science.gov (United States)

    Laosunthara, Ampan; Akatsuka, Hiroshi

    2016-09-01

    In previous study, we experimentally examined physical properties of supersonic flow of weakly ionized expanding arc-jet plasma through an open magnetic field line (Bmax 0.16T). We found supersonic velocity of helium plasma up to Mach 3 and the space potential drop at the end of the magnets. To understand the plasma in numerical point of view, the flows of ion and neutral are treated by particle-based Direct Simulation Monte Carlo (DSMC) method, electron is treated as a fluid. The previous numerical study, we assumed 2 conditions. Ion and electron temperatures were the same (LTE condition). Ion and electron velocities were the same (current-free condition). We found that ion velocity decreased by collision with residual gas molecules (background pressure). We also found that space potential changing with background pressure. In other words, it was indicated that electric field exists and the current-free assumption is not proper. In this study, we add electron continuity and electron momentum equations to obtain electron velocity and space potential. We find that space potential changing with background pressure slightly. It is indicated that electron is essential to space potential formation than ion.

  15. In situ monitoring the effects of a magnetic field on the open-circuit corrosion states of iron in acidic and neutral solutions

    International Nuclear Information System (INIS)

    Lu Zhanpeng; Yang Wu

    2008-01-01

    The effects of a 0.4 T horizontal magnetic field (HMF) on the open-circuit corrosion states of iron in static aqueous solutions are studied by in situ monitoring the responses of two electrochemical parameters to the applied magnetic field, i.e. the open-circuit potential (OCP) and the current under potentiostatic polarization. The applied magnetic field makes the OCP shift in the noble direction. Withdrawing the magnetic field causes a negative shift of the OCP in acidic solutions, but it does not cause any significant change of OCP in neutral solutions. Imposing a magnetic field induces a cathodic current for iron that was previously potentiostatically polarized at the OCP without magnetic field. Withdrawing the magnetic field induces an anodic current for iron that was previously potentiostatically polarized at the OCP with the magnetic field. The magnetic field effect is more significant in the acid solutions than in the salt solutions. The magnetic field effects on the oxygen reduction and on the activation-controlled iron dissolution reaction are found to be insignificant. The magnetic field effect on the hydrogen reduction reaction on iron in acidic solutions is demonstrated. Results show the possibility that a magnetic field would affect the hydrogen evolution by enhancing the electron-transfer process that has been categorized in the classical electrochemistry kinetics to be the rate-determining process. The memory effect of the magnetic field on the electrochemical reaction is identified and discussed

  16. The effect of a feedback signal in a computer mouse on hovering behaviour, productivity, comfort and usability in a field study

    NARCIS (Netherlands)

    Kraker, H. de; Korte, E. de; Mil, F. van; Rijs, B.; Bongers, P.

    2008-01-01

    The aim of this study was to determine the effect of a tactile feedback signal on hovering behaviour, productivity, usability and comfort after 1 week of using an experimental mouse. In a randomized controlled trial, a regular computer mouse was compared to a new developed mouse with a tactile,

  17. Parallel transport of long mean-free-path plasma along open magnetic field lines: Parallel heat flux

    International Nuclear Information System (INIS)

    Guo Zehua; Tang Xianzhu

    2012-01-01

    In a long mean-free-path plasma where temperature anisotropy can be sustained, the parallel heat flux has two components with one associated with the parallel thermal energy and the other the perpendicular thermal energy. Due to the large deviation of the distribution function from local Maxwellian in an open field line plasma with low collisionality, the conventional perturbative calculation of the parallel heat flux closure in its local or non-local form is no longer applicable. Here, a non-perturbative calculation is presented for a collisionless plasma in a two-dimensional flux expander bounded by absorbing walls. Specifically, closures of previously unfamiliar form are obtained for ions and electrons, which relate two distinct components of the species parallel heat flux to the lower order fluid moments such as density, parallel flow, parallel and perpendicular temperatures, and the field quantities such as the magnetic field strength and the electrostatic potential. The plasma source and boundary condition at the absorbing wall enter explicitly in the closure calculation. Although the closure calculation does not take into account wave-particle interactions, the results based on passing orbits from steady-state collisionless drift-kinetic equation show remarkable agreement with fully kinetic-Maxwell simulations. As an example of the physical implications of the theory, the parallel heat flux closures are found to predict a surprising observation in the kinetic-Maxwell simulation of the 2D magnetic flux expander problem, where the parallel heat flux of the parallel thermal energy flows from low to high parallel temperature region.

  18. Opening the Field

    DEFF Research Database (Denmark)

    Odgaard, Martin

    2012-01-01

    The perspective of this paper is to showcase the synergy that lies within a new urban-nature ecology framework. The aim is two-sided - on one side it is an exploration of how to work with landscape ecology in urban- and landscape design with a special emphasis on biodiver-sity. It is my claim, th...

  19. Effects of Liver Fibrosis Progression on Tissue Relaxation Times in Different Mouse Models Assessed by Ultrahigh Field Magnetic Resonance Imaging

    Directory of Open Access Journals (Sweden)

    Andreas Müller

    2017-01-01

    Full Text Available Recently, clinical studies demonstrated that magnetic resonance relaxometry with determination of relaxation times T1 and T2⁎ may aid in staging and management of liver fibrosis in patients suffering from viral hepatitis and steatohepatitis. In the present study we investigated T1 and T2⁎ in different models of liver fibrosis to compare alternate pathophysiologies in their effects on relaxation times and to further develop noninvasive quantification methods of liver fibrosis. MRI was performed with a fast spin echo sequence for measurement of T1 and a multigradient echo sequence for determination of T2⁎. Toxic liver fibrosis was induced by injections of carbon tetrachloride (1.4 mL CCl4 per kg bodyweight and week, for 3 or 6 weeks in BALB/cJ mice. Chronic sclerosing cholangitis was mimicked using the ATP-binding cassette transporter B4 knockout (Abcb4 -/- mouse model. Untreated BALB/cJ mice served as controls. To assess hepatic fibrosis, we ascertained collagen contents and fibrosis scores after Sirius red staining. T1 and T2⁎ correlate differently to disease severity and etiology of liver fibrosis. T2⁎ shows significant decrease correlating with fibrosis in CCl4 treated animals, while demonstrating significant increase with disease severity in Abcb4 -/- mice. Measurements of T1 and T2⁎ may therefore facilitate discrimination between different stages and causes of liver fibrosis.

  20. Open solar flux estimates from near-Earth measurements of the interplanetary magnetic field: comparison of the first two perihelion passes of the Ulysses spacecraft

    Directory of Open Access Journals (Sweden)

    M. Lockwood

    2004-04-01

    Full Text Available Results from all phases of the orbits of the Ulysses spacecraft have shown that the magnitude of the radial component of the heliospheric field is approximately independent of heliographic latitude. This result allows the use of near-Earth observations to compute the total open flux of the Sun. For example, using satellite observations of the interplanetary magnetic field, the average open solar flux was shown to have risen by 29% between 1963 and 1987 and using the aa geomagnetic index it was found to have doubled during the 20th century. It is therefore important to assess fully the accuracy of the result and to check that it applies to all phases of the solar cycle. The first perihelion pass of the Ulysses spacecraft was close to sunspot minimum, and recent data from the second perihelion pass show that the result also holds at solar maximum. The high level of correlation between the open flux derived from the various methods strongly supports the Ulysses discovery that the radial field component is independent of latitude. We show here that the errors introduced into open solar flux estimates by assuming that the heliospheric field's radial component is independent of latitude are similar for the two passes and are of order 25% for daily values, falling to 5% for averaging timescales of 27 days or greater. We compare here the results of four methods for estimating the open solar flux with results from the first and second perehelion passes by Ulysses. We find that the errors are lowest (1–5% for averages over the entire perehelion passes lasting near 320 days, for near-Earth methods, based on either interplanetary magnetic field observations or the aa geomagnetic activity index. The corresponding errors for the Solanki et al. (2000 model are of the order of 9–15% and for the PFSS method, based on solar magnetograms, are of the order of 13–47%. The model of Solanki et al. is based on the continuity equation of open flux, and uses the

  1. Converting the Literature of a Scientific Field to Open Access through Global Collaboration: The Experience of SCOAP3 in Particle Physics

    Directory of Open Access Journals (Sweden)

    Alexander Kohls

    2018-04-01

    Full Text Available Gigantic particle accelerators, incredibly complex detectors, an antimatter factory and the discovery of the Higgs boson—this is part of what makes CERN famous. Only a few know that CERN also hosts the world largest Open Access initiative: SCOAP3. The Sponsoring Consortium for Open Access Publishing in Particle Physics started operation in 2014 and has since supported the publication of 20,000 Open Access articles in the field of particle physics, at no direct cost, nor burden, for individual authors worldwide. SCOAP3 is made possible by a 3000-institute strong partnership, where libraries re-direct funds previously used for subscriptions to ‘flip’ articles to ‘Gold Open Access’. With its recent expansion, the initiative now covers about 90% of the journal literature of the field. This article describes the economic principles of SCOAP3, the collaborative approach of the partnership, and finally summarizes financial results after four years of successful operation.

  2. Demonstrating Empathy for Foreign-Born Employees through Openness and Acceptance: A Quasi-Experimental Field Study.

    Science.gov (United States)

    Stull, James B.

    1986-01-01

    Reports on a study measuring foreign-born employees' perceptions of supervisors' acceptance of and openness to "open" messages from the employee. Suggests ways to improve supervisory demonstrations of empathy. (MS)

  3. Models of red giants in the CoRoT asteroseismology fields combining asteroseismic and spectroscopic constraints - The open cluster NGC 6633 and field stars-

    Science.gov (United States)

    Lagarde, Nadège; Miglio, Andrea; Eggenberger, Patrick; Morel, Thierry; Montalbàn, Josefina; Mosser, Benoit

    2015-08-01

    The availability of asteroseismic constraints for a large sample of red giant stars from the CoRoT and Kepler missions paves the way for various statistical studies of the seismic properties of stellar populations.We use the first detailed spectroscopic study of CoRoT red-giant stars (Morel et al 2014) to compare theoretical stellar evolution models to observations of the open cluster NGC 6633 and field stars.In order to explore the effects of rotation-induced mixing and thermohaline instability, we compare surface abundances of carbon isotopic ratio and lithium with stellar evolution predictions. These chemicals are sensitive to extra-mixing on the red-giant branch.We estimate mass, radius, and distance for each star using the seismic constraints. We note that the Hipparcos and seismic distances are different. However, the uncertainties are such that this may not be significant. Although the seismic distances for the cluster members are self consistent they are somewhat larger than the Hipparcos distance. This is an issue that should be considered elsewhere. Models including thermohaline instability and rotation-induced mixing, together with the seismically determined masses can explain the chemical properties of red-giants targets. Tighter constraints on the physics of the models would be possible if there were detailed knowledge of the core rotation rate and the asymptotic period spacing.

  4. Three-dimensional plasma transport in open chaotic magnetic fields. A computational assessment for tokamak edge layers

    International Nuclear Information System (INIS)

    Frerichs, Heinke Gerd

    2010-04-01

    The development of nuclear fusion as an alternative energy source requires the research on magnetically confined, high temperature plasmas. In particular, the quantification of plasma flows in the domain near exposed material surfaces of the plasma container by computer simulations is of key importance, both for guiding interpretation of present fusion experiments and for aiding the ongoing design activities for large future devices such as ITER, W7-X or the DEMO reactor. There is a large number of computational issues related to the physics of hot, fully ionized and magnetized plasmas near surfaces of the vacuum chamber. This thesis is dedicated to one particular such challenge, namely the numerical quantification of self-consistent kinetic neutral gas and plasma fluid flows in very complex 3D (partially chaotic) magnetic fields, in the absence of any common symmetries for plasma and neutral gas dynamics. Such magnetic field configurations are e.g. generated by externally applied magnetic perturbations at the plasma edge, and are of great interest for the control of particle and energy exhausts. In the present thesis the 3D edge plasma and neutral particle transport code EMC3-EIRENE is applied to two distinct configurations of open chaotic magnetic system: at the TEXTOR and DIII-D tokamaks. Improvements of the edge transport model and extensions of the transport code are presented, which have allowed such simulations for the first time for 3D scenarios at DIII-D with ITER similar plasmas. A strong 3D effect of the chaotic magnetic field on the DIII-D edge plasma is found and analyzed in detail. It is found that a pronounced striation pattern of target particle and heat fluxes at DIII-D can only be obtained up to a certain upper limiting level of anomalous cross-field transport. Hence, in comparison to experimental data, these findings allow to narrow down the range of this model parameter. One particular interest at TEXTOR is the achievement of a regime with

  5. Exposure to an open-field arena increases c-Fos expression in a distributed anxiety-related system projecting to the basolateral amygdaloid complex

    DEFF Research Database (Denmark)

    Hale, M.W.; Hay-Schmidt, A.; Mikkelsen, J.D.

    2008-01-01

    Anxiety states and anxiety-related behaviors appear to be regulated by a distributed and highly interconnected system of brain structures including the basolateral amygdala. Our previous studies demonstrate that exposure of rats to an open-field in high- and low-light conditions results in a marked...... increase in c-Fos expression in the anterior part of the basolateral amygdaloid nucleus (BLA) compared with controls. The neural mechanisms underlying the anatomically specific effects of open-field exposure on c-Fos expression in the BLA are not clear, however, it is likely that this reflects activation...... to this region in combination with c-Fos immunostaining to identify cells responding to exposure to an open-field arena in low-light (8-13 lux) conditions (an anxiogenic stimulus in rats). Adult male Wistar rats received a unilateral microinjection of 4% CTb in phosphate-buffered saline into the basolateral...

  6. Lithium ameliorates open-field and elevated plus maze behaviors, and brain phospho-glycogen synthase kinase 3-beta expression in fragile X syndrome model mice.

    Science.gov (United States)

    Chen, Xi; Sun, Weiwen; Pan, Ying; Yang, Quan; Cao, Kaiyi; Zhang, Jin; Zhang, Yizhi; Chen, Mincong; Chen, Feidi; Huang, Yueling; Dai, Lijun; Chen, Shengqiang

    2013-10-01

    To investigate whether lithium modifies open-field and elevated plus maze behavior, and brain phospho-glycogen synthase kinase 3 (P-GSK3beta) expression in Fmr1 knockout mice. One hundred and eighty FVB mice, including knockout and wild type, with an age of 30 days were used. An open-field and elevated plus maze was utilized to test behavior, while western blot was used to measure the P-GSK3beta expression. Six groups were formed: control (saline), lithium chloride 30, 60, 90, 120, and 200 mg/kg. The experiments were carried out in the Institute of Neuroscience, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China between January and June 2012. Lithium significantly decreased total distance, crossing, central area time, and center entry in the open-field test (popen-arm tracking, open-arm entry, and open-arm time in the elevated plus maze (popen-field and elevated plus maze behaviors of Fmr1 knockout mice. This effect may be related to its enhancement of P-GSK3beta expression. Our findings suggest that lithium might have a therapeutic effect in fragile X syndrome.

  7. The correspondence between dayside long-period geomagnetic pulsations and the open-closed field line boundary

    Science.gov (United States)

    Pilipenko, V. A.; Kozyreva, O. V.; Lorentzen, D. A.; Baddeley, L. J.

    2018-05-01

    Long-period pulsations in the nominal Pc5-6 band (periods about 3-15 min) have been known to be a persistent feature of dayside high latitudes. A mixture of broadband Irregular Pulsations at Cusp Latitudes (IPCL) and narrowband P≿5 waves is often observed. The mechanism and origin of IPCL have not been firmly established yet. Magnetopause surface eigenmodes were suggested as a potential source of high-latitude ULF waves with frequencies less than 2 mHz. A ground response to these modes is expected to be beneath the ionospheric projection of the open-closed field line boundary (OCB). To unambiguously resolve a possible association of IPCL with the magnetopause surface modes, multi-instrument observation data from Svalbard have been analyzed. We examine the latitudinal structure of high-latitude pulsations in the Pc5-6 band recorded by magnetometers covering near-cusp latitudes. This structure is compared with an instant location of the equatorward boundary of the cusp aurora, assumed to be a proxy of the OCB. The optical OCB latitude has been identified by an automatic algorithm, using data from the meridian scanning photometer at Longyearbyen, Svalbard. The comparison has shown that the latitudinal maximum of the broadband IPCL maximizes about 2°-3° deeper in the magnetosphere than the OCB optical proxy. Therefore, these pulsations cannot be associated with the ground image of the magnetopause surface modes. It is likely that an essentially non-dipole geometry of field lines and a high variability of the magnetopause region may suppress the excitation efficiency. The obtained result imposes important limitations on possible mechanisms of high-latitude dayside ULF variations.

  8. Changes of visual-field global indices after cataract surgery in primary open-angle glaucoma patients.

    Science.gov (United States)

    Seol, Bo Ram; Jeoung, Jin Wook; Park, Ki Ho

    2016-11-01

    To determine changes of visual-field (VF) global indices after cataract surgery and the factors associated with the effect of cataracts on those indices in primary open-angle glaucoma (POAG) patients. A retrospective chart review of 60 POAG patients who had undergone phacoemulsification and intraocular lens insertion was conducted. All of the patients were evaluated with standard automated perimetry (SAP; 30-2 Swedish interactive threshold algorithm; Carl Zeiss Meditec Inc.) before and after surgery. VF global indices before surgery were compared with those after surgery. The best-corrected visual acuity, intraocular pressure (IOP), number of glaucoma medications before surgery, mean total deviation (TD) values, mean pattern deviation (PD) value, and mean TD-PD value were also compared with the corresponding postoperative values. Additionally, postoperative peak IOP and mean IOP were evaluated. Univariate and multivariate logistic regression analyses were performed to identify the factors associated with the effect of cataract on global indices. Mean deviation (MD) after cataract surgery was significantly improved compared with the preoperative MD. Pattern standard deviation (PSD) and visual-field index (VFI) after surgery were similar to those before surgery. Also, mean TD and mean TD-PD were significantly improved after surgery. The posterior subcapsular cataract (PSC) type showed greater MD changes than did the non-PSC type in both the univariate and multivariate logistic regression analyses. In the univariate logistic regression analysis, the preoperative TD-PD value and type of cataract were associated with MD change. However, in the multivariate logistic regression analysis, type of cataract was the only associated factor. None of the other factors was associated with MD change. MD was significantly affected by cataracts, whereas PSD and VFI were not. Most notably, the PSC type showed better MD improvement compared with the non-PSC type after cataract surgery

  9. Risk factors for predicting visual field progression in Chinese patients with primary open-angle glaucoma: A retrospective study.

    Science.gov (United States)

    Hung, Kuo-Hsuan; Cheng, Ching-Yu; Liu, Catherine Jui-Ling

    2015-07-01

    Glaucoma is a leading cause of irreversible blindness worldwide. It is characterized by progressive deterioration of the visual field (VF) that results in a complete loss of vision. This study aimed to determine the risk factors associated with VF progression in Chinese patients with primary open-angle glaucoma (POAG). We reviewed the charts of POAG patients who visited our clinic between July 2009 and June 2010. We included patients with five or more reliable VF tests using the Humphrey Field Analyzer (Humphrey Instruments, San Leandro, CA, USA) during a period of at least 2 years. The scoring system of the Collaborative Initial Glaucoma Treatment Study (CIGTS) was used to code the VF. Progression was defined as an increasing score ≥3, compared to the averaged baseline data. Univariate and multivariate logistic regression analyses were performed to identify the risk factors of VF progression. There were 92 patients (representing 92 eyes) with an average of 8.9 reliable VFs over a mean follow up of 5.4 years. Multivariate logistic regression showed that eyes with more VF tests [odds ratio (OR) = 1.500, p < 0.010] and either increased peak intraocular pressure (IOP) (OR = 1.235, p = 0.044) or a wide IOP range (OR = 1.165, p = 0.041) favored VF progression. High myopia (less than -6.0 D) was not a risk factor (OR = 1.289, p = 0.698) for VF progression in this study. In addition to a greater number of VF tests, Chinese patients with treated POAG who experienced a high peak IOP or a wide range of IOP during follow up were more likely to have VF deterioration. Copyright © 2015. Published by Elsevier Taiwan.

  10. Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma.

    Science.gov (United States)

    Naito, Tomoko; Yoshikawa, Keiji; Mizoue, Shiro; Nanno, Mami; Kimura, Tairo; Suzumura, Hirotaka; Takeda, Ryuji; Shiraga, Fumio

    2015-01-01

    To analyze the relationship between consecutive deterioration of mean deviation (MD) value and glaucomatous visual field (VF) progression in open-angle glaucoma (OAG), including primary OAG and normal tension glaucoma. The subjects of the study were patients undergoing treatment for OAG who had performed VF tests at least 10 times with a Humphrey field analyzer (SITA standard, C30-2 program). The VF progression was defined by a significantly negative MD slope (MD slope worsening) at the final VF test during the follow-up period. The relationship between the MD slope worsening and the consecutive deterioration of MD value were retrospectively analyzed. A total of 165 eyes of 165 patients were included in the analysis. Significant progression of VF defects was observed in 72 eyes of 72 patients (43.6%), while no significant progression was evident in 93 eyes of 93 patients (56.4%). There was significant relationship between the frequency of consecutive deterioration of MD value and MD slope worsening (P<0.0001, Cochran-Armitage trend test). A significant association was observed for MD slope worsening in the eyes with three (odds ratio: 2.1, P=0.0224) and four (odds ratio: 3.6, P=0.0008) consecutive deterioration of MD value in multiple logistic regression analysis, but no significant association in the eyes with two consecutive deterioration (odds ratio: 1.1, P=0.8282). The eyes with VF progression had significantly lower intraocular pressure reduction rate (P<0.01). This retrospective study has shown that three or more consecutive deterioration of MD value might be a predictor to future significant MD slope worsening in OAG.

  11. Photometric studies of two W UMa type variables in the field of distant open cluster NGC 6866

    International Nuclear Information System (INIS)

    Joshi, Yogesh Chandra; Joshi, Santosh; Jagirdar, Rukmini

    2016-01-01

    We present photometric analysis of the two W UMa type binaries identified in the field of distant open star cluster NGC 6866. Although these systems, namely ID487 and ID494, were reported by Joshi et al., a detailed study of these stars has not been carried out before. The orbital periods of these stars are found to be 0.415110±0.000001 day and 0.366709±0.000004 day, respectively. Based on the photometric and infrared colors, we find their respective spectral types to be K0 and K3. The photometric light variations of both stars show the O'Connell effect which can be explained by employing a dark spot on the secondary components. The V and I band light curves are analyzed using the Wilson-Devinney (WD) code and relations given by Gazeas which yield radii and masses for the binary components of star ID487 of R 1 = 1.24 ± 0.01 R ⊙ , R 2 = 1.11 ± 0.02 R ⊙ , and M 1 = 1.24 ± 0.02 M ⊙ , M 2 = 0.96 ± 0.05 M ⊙ and for star ID494 of R 1 = 1.22±0.02R ⊙ , R 2 = 0.81±0.01 R ⊙ , and M 1 = 1.20±0.06 M ⊙ , M 2 = 0.47±0.01 M ⊙ . (paper)

  12. Is high myopia a risk factor for visual field progression or disk hemorrhage in primary open-angle glaucoma?

    Science.gov (United States)

    Nitta, Koji; Sugiyama, Kazuhisa; Wajima, Ryotaro; Tachibana, Gaku

    2017-01-01

    The purpose of this study was to clarify differences between highly myopic and non-myopic primary open-angle glaucoma (POAG) patients, including normal-tension glaucoma patients. A total of 269 POAG patients were divided into two groups: patients with ≥26.5 mm of axial length (highly myopic group) and patients with field (VF) loss was significantly greater in the highly myopic group (10-year survival rate, 73.7%±6.8%) than in the non-myopic group (10-year survival rate, 46.3%±5.8%; log-rank test, P =0.0142). The occurrence of disk hemorrhage (DH) in the non-myopic group (1.60±3.04) was significantly greater than that in the highly myopic group (0.93±2.13, P =0.0311). The cumulative probability of DH was significantly lower in the highly myopic group (10-year survival rate, 26.4%±5.4%) than in the non-myopic group (10-year survival rate, 47.2%±6.6%, P =0.0413). Highly myopic POAG is considered as a combination of myopic optic neuropathy and glaucomatous optic neuropathy (GON). If GON is predominant, it has frequent DH and more progressive VF loss. However, when the myopic optic neuropathy is predominant, it has less DH and less progressive VF loss.

  13. Behavioral effects of antiepileptic drugs in rats: Are the effects on mood and behavior detectable in open-field test?

    Science.gov (United States)

    Zimcikova, Eva; Simko, Julius; Karesova, Iva; Kremlacek, Jan; Malakova, Jana

    2017-11-01

    Behavioral side effects of antiepileptic drugs (AEDs) are common including both positive and negative effects on mood, anxiety, depression, and psychosis. We aimed to evaluate behavioral patterns in rats after administration of lamotrigine, levetiracetam, phenytoin, topiramate, carbamazepine, gabapentin, pregabalin, and zonisamide. The open-field test was performed and locomotion, rearing, grooming, central latency and defecation were recorded over a 5min interval for each rat (8 rats in each group receiving AED and 16 controls). Kruskal-Wallis nonparametric test or ANOVA were used to assess differences among the groups. The experimental groups did not differ in latency to enter the center compartment, neither in the decline of locomotor activity in the 1st and the 5th minute of the observation, nor in number of rears. Significant differences among groups were observed in the total number of lines crossed, grooming, as well in the number of fecal pellets. Locomotor activity was significantly increased in lamotrigine, if compared with gabapentin and pregabalin (ANOVA; p <0.05). Rats exposed to topiramate displayed a significantly increased number of grooming (when compared to pregabalin: p<0.01). Defecation (the number of fecal pellets) significantly increased in the gabapentin and carbamazepine group. There are significant differences between AEDs in terms of their behavioral profile. It is of great importance to evaluate these effects in clinical practice to bring more clear insight into these positive or negative side effects of AEDs. Copyright © 2017 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

  14. Effect of perphenazine enanthate on open-field test behaviour and stress-induced hyperthermia in domestic sheep.

    Science.gov (United States)

    Pedernera-Romano, Cecilia; Ruiz de la Torre, José L; Badiella, Llorenç; Manteca, Xavier

    2010-01-01

    The open-field test (OFT) and stress-induced hyperthermia (SIH) have been used to measure individual differences in fear. The present study has been designed as a pharmacological validation of OFT and SIH as indicators of fear in sheep using perphenazine enanthate (PPZ), a long-acting neuroleptic. Twenty four ewes of two breeds, Lacaune and Ripollesa, were tested in an arena measuring 5mx2.5m. Treatment group received one dose of 1.5mg/kg of PPZ and control group received sterile sesame oil. All animals were tested for 10min and behaviours were recorded. Rectal temperature was measured at the beginning (T1) and at the end (T2) of the test. SIH was defined as the difference between T2 and T1. Sheep were tested on days 1, 2, 3, 4, 7 and 9 after PPZ injection. Variables were analysed using a mixed model. PPZ decreased bleats on days 2, 3, 4 and the SIH response on days 2 and 3. Breed differences were observed. Treated animals showed positive correlations between SIH and bleats; squares entered; attempts to escape and negative correlation between SIH and visits to the food bucket. Our results suggest that behaviour and SIH on the OFT are useful measures of fear in sheep.

  15. Observation of enhanced electric field in an RF-plugged sheet plasma in the RFC-XX-M open-ended machine

    International Nuclear Information System (INIS)

    Oda, T.; Takiyama, K.; Kadota, K.

    1987-12-01

    We report nonperturbing observation of the electric field in the sheet plasma for RF end-plugging on the RFC XX-M open-ended machine by using the Stark effect with a combined technique of beam-probe and laser-induced fluorescence. Under the optimum condition for the RF plugging, enhanced electric field is found in the sheet plasma by about 2.5 times with respect to the electric field when no plasma is produced. The field spatial profile is also measured, which is discussed in connection with the electrostatic eigenmode. (author)

  16. Occurrence of CYP1B1 Mutations in Juvenile Open-Angle Glaucoma With Advanced Visual Field Loss.

    Science.gov (United States)

    Souzeau, Emmanuelle; Hayes, Melanie; Zhou, Tiger; Siggs, Owen M; Ridge, Bronwyn; Awadalla, Mona S; Smith, James E H; Ruddle, Jonathan B; Elder, James E; Mackey, David A; Hewitt, Alex W; Healey, Paul R; Goldberg, Ivan; Morgan, William H; Landers, John; Dubowsky, Andrew; Burdon, Kathryn P; Craig, Jamie E

    2015-07-01

    Juvenile open-angle glaucoma (JOAG) is a severe neurodegenerative eye disorder in which most of the genetic contribution remains unexplained. To assess the prevalence of pathogenic CYP1B1 sequence variants in an Australian cohort of patients with JOAG and severe visual field loss. For this cohort study, we recruited 160 patients with JOAG classified as advanced (n = 118) and nonadvanced (n = 42) through the Australian and New Zealand Registry of Advanced Glaucoma from January 1, 2007, through April 1, 2014. Eighty individuals with no evidence of glaucoma served as a control group. We defined JOAG as diagnosis before age 40 years and advanced JOAG as visual field loss in 2 of the 4 central fixation squares on a reliable visual field test result. We performed direct sequencing of the entire coding region of CYP1B1. Data analysis was performed in October 2014. Identification and characterization of CYP1B1 sequence variants. We identified 7 different pathogenic variants among 8 of 118 patients with advanced JOAG (6.8%) but none among the patients with nonadvanced JOAG. Three patients were homozygous or compound heterozygous for CYP1B1 pathogenic variants, which provided a likely basis for their disease. Five patients were heterozygous. The allele frequency among the patients with advanced JOAG (11 in 236 [4.7%]) was higher than among our controls (1 in 160 [0.6%]; P = .02; odds ratio, 7.8 [95% CI, 0.02-1.0]) or among the control population from the Exome Aggregation Consortium database (2946 of 122 960 [2.4%]; P = .02; odds ratio, 2.0 [95% CI, 0.3-0.9]). Individuals with CYP1B1 pathogenic variants, whether heterozygous or homozygous, had worse mean (SD) deviation on visual fields (-24.5 [5.1] [95% CI, -31.8 to -17.2] vs -15.6 [10.0] [95% CI, -17.1 to -13.6] dB; F1,126 = 5.90; P = .02; partial ηp2 = 0.05) and were younger at diagnosis (mean [SD] age, 23.1 [8.4] [95% CI, 17.2-29.1] vs 31.5 [8.0] [95% CI, 30.1-33.0] years; F1,122 = 7

  17. [Does open access publishing increase the impact of scientific articles? An empirical study in the field of intensive care medicine].

    Science.gov (United States)

    Riera, M; Aibar, E

    2013-05-01

    Some studies suggest that open access articles are more often cited than non-open access articles. However, the relationship between open access and citations count in a discipline such as intensive care medicine has not been studied to date. The present article analyzes the effect of open access publishing of scientific articles in intensive care medicine journals in terms of citations count. We evaluated a total of 161 articles (76% being non-open access articles) published in Intensive Care Medicine in the year 2008. Citation data were compared between the two groups up until April 30, 2011. Potentially confounding variables for citation counts were adjusted for in a linear multiple regression model. The median number (interquartile range) of citations of non-open access articles was 8 (4-12) versus 9 (6-18) in the case of open access articles (p=0.084). In the highest citation range (>8), the citation count was 13 (10-16) and 18 (13-21) (p=0.008), respectively. The mean follow-up was 37.5 ± 3 months in both groups. In the 30-35 months after publication, the average number (mean ± standard deviation) of citations per article per month of non-open access articles was 0.28 ± 0.6 versus 0.38 ± 0.7 in the case of open access articles (p=0.043). Independent factors for citation advantage were the Hirsch index of the first signing author (β=0.207; p=0.015) and open access status (β=3.618; p=0.006). Open access publishing and the Hirsch index of the first signing author increase the impact of scientific articles. The open access advantage is greater for the more highly cited articles, and appears in the 30-35 months after publication. Copyright © 2012 Elsevier España, S.L. and SEMICYUC. All rights reserved.

  18. Relations between open-field, elevated plus-maze, and emergence tests as displayed by C57/BL6J and BALB/c mice.

    Science.gov (United States)

    Lalonde, R; Strazielle, C

    2008-06-15

    The relations between open-field, elevated plus-maze, and emergence tests were examined in two strains of mice. In the open-field, C57BL/6J mice had more ambulatory movements and rears but not stereotyped movements relative to BALB/c. In addition, C57BL/6J mice entered more often than BALB/c into enclosed and open arms of the elevated plus-maze. When placed inside a large enclosure, C57BL/6J mice emerged more quickly than BALB/c from a small toy object. In the entire series of mice, ambulation and rears in the open-field were linearly correlated with open and enclosed arm visits in the elevated plus-maze. Ambulatory movements and rears were also correlated with emergence latencies. In contrast, stereotyped movements were correlated with emergence latencies, but not with any elevated plus-maze value. These results specify the extent and limits of association between the three tests.

  19. Thin minimal rim width at Bruch’s membrane opening is associated with glaucomatous paracentral visual field loss

    Directory of Open Access Journals (Sweden)

    Taniguchi EV

    2017-12-01

    Full Text Available Elise V Taniguchi,1–3 Eleftherios I Paschalis,1,2 Dejiao Li,1,4 Kouros Nouri-Mahdavi,5 Stacey C Brauner,1 Scott H Greenstein,1 Angela V Turalba,1 Janey L Wiggs,1 Louis R Pasquale,1,6 Lucy Q Shen1 1Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA, 2Boston Keratoprosthesis Laboratory, Massachusetts Eye and Ear – Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA; 3Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, Brazil; 4Department of Ophthalmology, Beijing China-Japan Friendship Hospital, Beijing, People’s Republic of China; 5Department of Ophthalmology, David Geffen School of Medicine and Stein Eye Institute, Los Angeles, CA, USA; 6Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA Purpose: To compare optic nerve head (ONH measurements in glaucomatous eyes with paracentral visual field (VF loss to eyes with peripheral VF loss and controls.Methods: Open-angle glaucoma (OAG patients with early paracentral VF loss or isolated peripheral VF loss as well as control subjects underwent ONH imaging with swept-source optical coherence tomography (OCT and retinal nerve fiber layer (RNFL imaging with spectral-domain OCT. Minimum rim width at Bruch’s membrane opening (BMO-MRW, lamina cribrosa depth (LCD, and RNFL thickness were compared among the glaucoma and control groups with one-way analysis of variance, Kruskal–Wallis test, and multiple regression analysis.Results: Twenty-nine eyes from 29 OAG patients (15 early paracentral and 14 isolated peripheral VF loss and 20 eyes of 20 control subjects were included. The early paracentral and isolated peripheral VF loss groups had similar VF mean deviation (MD (–5.3±2.7 dB and –3.7±3.0 dB, p=0.15, respectively. Global BMO-MRW was lower in OAG eyes than in controls (193.8±40.0 vs 322.7±62.2 µm, p<0.001, but similar

  20. Generation of iPSC from cardiac and tail-tip fibroblasts derived from a second heart field reporter mouse.

    Science.gov (United States)

    Linares, Javier; Arellano-Viera, Estibaliz; Iglesias-García, Olalla; Ferreira, Carmen; Iglesias, Elena; Abizanda, Gloria; Prósper, Felipe; Carvajal-Vergara, Xonia

    2016-05-01

    Mef2c Anterior Heart Field (AHF) enhancer is activated during embryonic heart development and it is expressed in multipotent cardiovascular progenitors (CVP) giving rise to endothelial and myocardial components of the outflow tract, right ventricle and ventricular septum. Here we have generated iPSC from transgenic Mef2c-AHF-Cre x Ai6(RCLZsGreen) mice. These iPSC will provide a novel tool to investigate the AHF-CVP and their cell progeny. Copyright © 2016 Roslin Cells Ltd. Published by Elsevier B.V. All rights reserved.